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[ [ "APPARATUS AND METHOD FOR LAUNCHING ELECTROMAGNETIC WAVES", "Aspects of the subject disclosure may include, for example, a system for receiving a communication signal, generating an electromagnetic wave from the communication signal, and inducing the electromagnetic wave on a portion of a transmission medium having an insulation layer with a tapered end covering at least part of a conductor.", "Other embodiments are disclosed." ], [ "1.A method, comprising: receiving, by a waveguide system including a waveguide structure, a first guided electromagnetic wave; and generating, by the waveguide system, a first communication signal according to the first guided electromagnetic wave; wherein the first guided electromagnetic wave propagates along an outer surface of an insulation layer, wherein the insulation layer has a tapered end, wherein a portion of the insulation layer has a substantially uniform outer diameter, wherein the portion of the insulation layer is within the waveguide structure, wherein the tapered end is outside of the waveguide structure, wherein the insulation layer covers a first portion of a conductor, and wherein the insulation layer enables a first radial dimension of a field of the first guided electromagnetic wave to decrease as the first guided electromagnetic wave propagates longitudinally along the tapered end towards the waveguide structure.", "2.The method of claim 1, wherein the waveguide structure has a conical structure.", "3.The method of claim 1, wherein the waveguide structure has a cylindrical structure.", "4.The method of claim 1, wherein the first radial dimension of the field of the first guided electromagnetic wave is less than or equal to a second radial dimension of an opening of the waveguide structure when the first guided electromagnetic wave is located within the opening, and wherein the waveguide system comprises a receiver for facilitating the receiving of the first guided electromagnetic wave from the outer surface of the insulation layer.", "5.The method of claim 1, wherein the first guided electromagnetic wave has a fundamental wave propagation mode.", "6.The method of claim 1, further comprising: receiving, by the waveguide system, a second communication signal that is distinct from the first communication signal; and inducing by the waveguide system, according to the second communication signal, a second guided electromagnetic wave on the outer surface of the insulation layer; wherein the second guided electromagnetic wave is distinct from the first guided electromagnetic wave.", "7.The method of claim 6, wherein a second radial dimension of the field of the second guided electromagnetic wave increases as the second guided electromagnetic wave propagates along the tapered end of the insulation layer away from the waveguide structure, and wherein the second radial dimension of the field of the second guided electromagnetic wave is less than or equal to a third radial dimension of an opening of the waveguide structure when the second guided electromagnetic wave is located within the opening of the waveguide structure.", "8.The method of claim 1, further comprising placing the insulation layer on an outer surface of the conductor.", "9.The method of claim 1, wherein a second portion of the conductor comprises another portion of the insulation layer.", "10.The method of claim 1, wherein a second portion of the conductor has no insulation.", "11.A system, comprising: an insulation material having a tapered end, the insulation material configured to cover a portion of a conductor; and a waveguide coupled to the insulation material to enable a first radial dimension of a field of a first guided electromagnetic wave to decrease while propagating longitudinally along the tapered end towards the waveguide, wherein a portion of the insulation material has a substantially uniform outer diameter, wherein the portion of the insulation material is within the waveguide, wherein the tapered end is outside of the waveguide, and wherein the portion of the insulation material within the waveguide results in a gap between an outer surface of the insulation material and an inner surface of the waveguide.", "12.The system of claim 11, wherein the waveguide has a tapered structure.", "13.The system of claim 11, wherein the waveguide has a cylindrical structure.", "14.The system of claim 11, wherein the waveguide comprises a cavity.", "15.The system of claim 14, wherein the first radial dimension is less than or equal to a cross-sectional dimension of the cavity of the waveguide when the first guided electromagnetic wave is located within the cross-sectional dimension of the cavity.", "16.The system of claim 11, wherein the waveguide is further adapted to transmit a second guided electromagnetic wave propagating away from the waveguide towards the tapered end of the insulation material.", "17.The system of claim 16, wherein a second radial dimension of the field of the second guided electromagnetic wave increases as the second guided electromagnetic wave propagates along the tapered end of the insulation material away from the waveguide.", "18.The system of claim 16, wherein a second radial dimension of the field of the second guided electromagnetic wave is less than or equal to a cross-sectional dimension of a cavity of the waveguide when the second guided electromagnetic wave is located within the cross-sectional dimension of the cavity.", "19.A system, comprising: a dielectric material configurable to cover a first portion of a conductor, wherein a first portion of the dielectric material has a substantially uniform longitudinal thickness, and wherein a second portion of the dielectric material has a variable longitudinal thickness; a waveguide system including a waveguide structure coupled to the dielectric material; and circuitry configured to facilitate performance of operations, the operations comprising: causing the waveguide system to receive, via the waveguide structure, an electromagnetic wave guided by the dielectric material; and causing the waveguide system to generate, according to the electromagnetic wave, a communication signal, wherein a field of the electromagnetic wave has a radial dimension that decreases as the electromagnetic wave propagates along the variable longitudinal thickness of the dielectric material away from a second portion of the conductor not covered by the dielectric material and towards the waveguide structure, wherein the first portion of the dielectric material is within the waveguide structure, and wherein the second portion of the dielectric material is outside of the waveguide structure.", "20.The system of claim 19, wherein the waveguide structure comprises a cavity." ], [ "<SOH> BACKGROUND <EOH>As smart phones and other portable devices increasingly become ubiquitous, and data usage increases, macrocell base station devices and existing wireless infrastructure in turn require higher bandwidth capability in order to address the increased demand.", "To provide additional mobile bandwidth, small cell deployment is being pursued, with microcells and picocells providing coverage for much smaller areas than traditional macrocells.", "In addition, most homes and businesses have grown to rely on broadband data access for services such as voice, video and Internet browsing, etc.", "Broadband access networks include satellite, 4G or 5G wireless, power line communication, fiber, cable, and telephone networks." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Reference will now be made to the accompanying drawings, which are not necessarily drawn to scale, and wherein: FIG.", "1 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIG.", "2 is a block diagram illustrating an example, non-limiting embodiment of a transmission device in accordance with various aspects described herein.", "FIG.", "3 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "4 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "5A is a graphical diagram illustrating an example, non-limiting embodiment of a frequency response in accordance with various aspects described herein.", "FIG.", "5B is a graphical diagram illustrating example, non-limiting embodiments of a longitudinal cross-section of an insulated wire depicting fields of guided electromagnetic waves at various operating frequencies in accordance with various aspects described herein.", "FIG.", "6 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "7 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "8 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "9A is a block diagram illustrating an example, non-limiting embodiment of a stub coupler in accordance with various aspects described herein.", "FIG.", "9B is a diagram illustrating an example, non-limiting embodiment of an electromagnetic distribution in accordance with various aspects described herein.", "FIGS.", "10A and 10B are block diagrams illustrating example, non-limiting embodiments of couplers and transceivers in accordance with various aspects described herein.", "FIG.", "11 is a block diagram illustrating an example, non-limiting embodiment of a dual stub coupler in accordance with various aspects described herein.", "FIG.", "12 is a block diagram illustrating an example, non-limiting embodiment of a repeater system in accordance with various aspects described herein.", "FIG.", "13 illustrates a block diagram illustrating an example, non-limiting embodiment of a bidirectional repeater in accordance with various aspects described herein.", "FIG.", "14 is a block diagram illustrating an example, non-limiting embodiment of a waveguide system in accordance with various aspects described herein.", "FIG.", "15 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIGS.", "16A & 16B are block diagrams illustrating an example, non-limiting embodiment of a system for managing a power grid communication system in accordance with various aspects described herein.", "FIG.", "17A illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A and 16B .", "FIG.", "17B illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A and 16B .", "FIGS.", "18A and 18B are block diagrams illustrating example, non-limiting embodiments of guided-wave communications systems in accordance with various aspects described herein.", "FIG.", "19 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIGS.", "20A and 20B illustrate flow diagrams of example, non-limiting embodiments of a method in accordance with various aspects described herein.", "FIG.", "21 is a block diagram of an example, non-limiting embodiment of a computing environment in accordance with various aspects described herein.", "FIG.", "22 is a block diagram of an example, non-limiting embodiment of a mobile network platform in accordance with various aspects described herein.", "FIG.", "23 is a block diagram of an example, non-limiting embodiment of a communication device in accordance with various aspects described herein.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATION(S) This application is a continuation of U.S. patent application Ser.", "No.", "14/722,285, filed May 27, 2015.All sections of the aforementioned application(s) are incorporated herein by reference in their entirety.", "FIELD OF THE DISCLOSURE The subject disclosure relates to guided electromagnetic wave communications.", "BACKGROUND As smart phones and other portable devices increasingly become ubiquitous, and data usage increases, macrocell base station devices and existing wireless infrastructure in turn require higher bandwidth capability in order to address the increased demand.", "To provide additional mobile bandwidth, small cell deployment is being pursued, with microcells and picocells providing coverage for much smaller areas than traditional macrocells.", "In addition, most homes and businesses have grown to rely on broadband data access for services such as voice, video and Internet browsing, etc.", "Broadband access networks include satellite, 4G or 5G wireless, power line communication, fiber, cable, and telephone networks.", "BRIEF DESCRIPTION OF THE DRAWINGS Reference will now be made to the accompanying drawings, which are not necessarily drawn to scale, and wherein: FIG.", "1 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIG.", "2 is a block diagram illustrating an example, non-limiting embodiment of a transmission device in accordance with various aspects described herein.", "FIG.", "3 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "4 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "5A is a graphical diagram illustrating an example, non-limiting embodiment of a frequency response in accordance with various aspects described herein.", "FIG.", "5B is a graphical diagram illustrating example, non-limiting embodiments of a longitudinal cross-section of an insulated wire depicting fields of guided electromagnetic waves at various operating frequencies in accordance with various aspects described herein.", "FIG.", "6 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "7 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "8 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "9A is a block diagram illustrating an example, non-limiting embodiment of a stub coupler in accordance with various aspects described herein.", "FIG.", "9B is a diagram illustrating an example, non-limiting embodiment of an electromagnetic distribution in accordance with various aspects described herein.", "FIGS.", "10A and 10B are block diagrams illustrating example, non-limiting embodiments of couplers and transceivers in accordance with various aspects described herein.", "FIG.", "11 is a block diagram illustrating an example, non-limiting embodiment of a dual stub coupler in accordance with various aspects described herein.", "FIG.", "12 is a block diagram illustrating an example, non-limiting embodiment of a repeater system in accordance with various aspects described herein.", "FIG.", "13 illustrates a block diagram illustrating an example, non-limiting embodiment of a bidirectional repeater in accordance with various aspects described herein.", "FIG.", "14 is a block diagram illustrating an example, non-limiting embodiment of a waveguide system in accordance with various aspects described herein.", "FIG.", "15 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIGS.", "16A & 16B are block diagrams illustrating an example, non-limiting embodiment of a system for managing a power grid communication system in accordance with various aspects described herein.", "FIG.", "17A illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A and 16B.", "FIG.", "17B illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A and 16B.", "FIGS.", "18A and 18B are block diagrams illustrating example, non-limiting embodiments of guided-wave communications systems in accordance with various aspects described herein.", "FIG.", "19 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIGS.", "20A and 20B illustrate flow diagrams of example, non-limiting embodiments of a method in accordance with various aspects described herein.", "FIG.", "21 is a block diagram of an example, non-limiting embodiment of a computing environment in accordance with various aspects described herein.", "FIG.", "22 is a block diagram of an example, non-limiting embodiment of a mobile network platform in accordance with various aspects described herein.", "FIG.", "23 is a block diagram of an example, non-limiting embodiment of a communication device in accordance with various aspects described herein.", "DETAILED DESCRIPTION One or more embodiments are now described with reference to the drawings, wherein like reference numerals are used to refer to like elements throughout the drawings.", "In the following description, for purposes of explanation, numerous details are set forth in order to provide a thorough understanding of the various embodiments.", "It is evident, however, that the various embodiments can be practiced without these details (and without applying to any particular networked environment or standard).", "In an embodiment, a guided wave communication system is presented for sending and receiving communication signals such as data or other signaling via guided electromagnetic waves.", "The guided electromagnetic waves include, for example, surface waves or other electromagnetic waves that are bound to or guided by a transmission medium.", "It will be appreciated that a variety of transmission media can be utilized with guided wave communications without departing from example embodiments.", "Examples of such transmission media can include one or more of the following, either alone or in one or more combinations: wires, whether insulated or not, and whether single-stranded or multi-stranded; conductors of other shapes or configurations including wire bundles, cables, rods, rails, pipes; non-conductors such as dielectric pipes, rods, rails, or other dielectric members; combinations of conductors and dielectric materials; or other guided wave transmission media.", "The inducement of guided electromagnetic waves on a transmission medium can be independent of any electrical potential, charge or current that is injected or otherwise transmitted through the transmission medium as part of an electrical circuit.", "For example, in the case where the transmission medium is a wire, it is to be appreciated that while a small current in the wire may be formed in response to the propagation of the guided waves along the wire, this can be due to the propagation of the electromagnetic wave along the wire surface, and is not formed in response to electrical potential, charge or current that is injected into the wire as part of an electrical circuit.", "The electromagnetic waves traveling on the wire therefore do not require a circuit to propagate along the wire surface.", "The wire therefore is a single wire transmission line that is not part of a circuit.", "Also, in some embodiments, a wire is not necessary, and the electromagnetic waves can propagate along a single line transmission medium that is not a wire.", "More generally, “guided electromagnetic waves” or “guided waves” as described by the subject disclosure are affected by the presence of a physical object that is at least a part of the transmission medium (e.g., a bare wire or other conductor, a dielectric, an insulated wire, a conduit or other hollow element, a bundle of insulated wires that is coated, covered or surrounded by a dielectric or insulator or other wire bundle, or another form of solid, liquid or otherwise non-gaseous transmission medium) so as to be at least partially bound to or guided by the physical object and so as to propagate along a transmission path of the physical object.", "Such a physical object can operate as at least a part of a transmission medium that guides, by way of an interface of the transmission medium (e.g., an outer surface, inner surface, an interior portion between the outer and the inner surfaces or other boundary between elements of the transmission medium), the propagation of guided electromagnetic waves, which in turn can carry energy, data and/or other signals along the transmission path from a sending device to a receiving device.", "Unlike free space propagation of wireless signals such as unguided (or unbounded) electromagnetic waves that decrease in intensity inversely by the square of the distance traveled by the unguided electromagnetic waves, guided electromagnetic waves can propagate along a transmission medium with less loss in magnitude per unit distance than experienced by unguided electromagnetic waves.", "Unlike electrical signals, guided electromagnetic waves can propagate from a sending device to a receiving device without requiring a separate electrical return path between the sending device and the receiving device.", "As a consequence, guided electromagnetic waves can propagate from a sending device to a receiving device along a transmission medium having no conductive components (e.g., a dielectric strip), or via a transmission medium having no more than a single conductor (e.g., a single bare wire or insulated wire).", "Even if a transmission medium includes one or more conductive components and the guided electromagnetic waves propagating along the transmission medium generate currents that flow in the one or more conductive components in a direction of the guided electromagnetic waves, such guided electromagnetic waves can propagate along the transmission medium from a sending device to a receiving device without requiring a flow of opposing currents on an electrical return path between the sending device and the receiving device.", "In a non-limiting illustration, consider electrical systems that transmit and receive electrical signals between sending and receiving devices by way of conductive media.", "Such systems generally rely on electrically separate forward and return paths.", "For instance, consider a coaxial cable having a center conductor and a ground shield that are separated by an insulator.", "Typically, in an electrical system a first terminal of a sending (or receiving) device can be connected to the center conductor, and a second terminal of the sending (or receiving) device can be connected to the ground shield.", "If the sending device injects an electrical signal in the center conductor via the first terminal, the electrical signal will propagate along the center conductor causing forward currents in the center conductor, and return currents in the ground shield.", "The same conditions apply for a two terminal receiving device.", "In contrast, consider a guided wave communication system such as described in the subject disclosure, which can utilize different embodiments of a transmission medium (including among others a coaxial cable) for transmitting and receiving guided electromagnetic waves without an electrical return path.", "In one embodiment, for example, the guided wave communication system of the subject disclosure can be configured to induce guided electromagnetic waves that propagate along an outer surface of a coaxial cable.", "Although the guided electromagnetic waves will cause forward currents on the ground shield, the guided electromagnetic waves do not require return currents to enable the guided electromagnetic waves to propagate along the outer surface of the coaxial cable.", "The same can be said of other transmission media used by a guided wave communication system for the transmission and reception of guided electromagnetic waves.", "For example, guided electromagnetic waves induced by the guided wave communication system on an outer surface of a bare wire, or an insulated wire can propagate along the bare wire or the insulated bare wire without an electrical return path.", "Consequently, electrical systems that require two or more conductors for carrying forward and reverse currents on separate conductors to enable the propagation of electrical signals injected by a sending device are distinct from guided wave systems that induce guided electromagnetic waves on an interface of a transmission medium without the need of an electrical return path to enable the propagation of the guided electromagnetic waves along the interface of the transmission medium.", "It is further noted that guided electromagnetic waves as described in the subject disclosure can have an electromagnetic field structure that lies primarily or substantially outside of a transmission medium so as to be bound to or guided by the transmission medium and so as to propagate non-trivial distances on or along an outer surface of the transmission medium.", "In other embodiments, guided electromagnetic waves can have an electromagnetic field structure that lies primarily or substantially inside a transmission medium so as to be bound to or guided by the transmission medium and so as to propagate non-trivial distances within the transmission medium.", "In other embodiments, guided electromagnetic waves can have an electromagnetic field structure that lies partially inside and partially outside a transmission medium so as to be bound to or guided by the transmission medium and so as to propagate non-trivial distances along the transmission medium.", "The desired electromagnetic field structure in an embodiment may vary based upon a variety of factors, including the desired transmission distance, the characteristics of the transmission medium itself, and environmental conditions/characteristics outside of the transmission medium (e.g., presence of rain, fog, atmospheric conditions, etc.).", "Various embodiments described herein relate to coupling devices, that can be referred to as “waveguide coupling devices”, “waveguide couplers” or more simply as “couplers”, “coupling devices” or “launchers” for launching and/or extracting guided electromagnetic waves to and from a transmission medium at millimeter-wave frequencies (e.g., 30 to 300 GHz), wherein the wavelength can be small compared to one or more dimensions of the coupling device and/or the transmission medium such as the circumference of a wire or other cross sectional dimension, or lower microwave frequencies such as 300 MHz to 30 GHz.", "Transmissions can be generated to propagate as waves guided by a coupling device, such as: a strip, arc or other length of dielectric material; a horn, monopole, rod, slot or other antenna; an array of antennas; a magnetic resonant cavity, or other resonant coupler; a coil, a strip line, a waveguide or other coupling device.", "In operation, the coupling device receives an electromagnetic wave from a transmitter or transmission medium.", "The electromagnetic field structure of the electromagnetic wave can be carried inside the coupling device, outside the coupling device or some combination thereof.", "When the coupling device is in close proximity to a transmission medium, at least a portion of an electromagnetic wave couples to or is bound to the transmission medium, and continues to propagate as guided electromagnetic waves.", "In a reciprocal fashion, a coupling device can extract guided waves from a transmission medium and transfer these electromagnetic waves to a receiver.", "According to an example embodiment, a surface wave is a type of guided wave that is guided by a surface of a transmission medium, such as an exterior or outer surface of the wire, or another surface of the wire that is adjacent to or exposed to another type of medium having different properties (e.g., dielectric properties).", "Indeed, in an example embodiment, a surface of the wire that guides a surface wave can represent a transitional surface between two different types of media.", "For example, in the case of a bare or uninsulated wire, the surface of the wire can be the outer or exterior conductive surface of the bare or uninsulated wire that is exposed to air or free space.", "As another example, in the case of insulated wire, the surface of the wire can be the conductive portion of the wire that meets the insulator portion of the wire, or can otherwise be the insulator surface of the wire that is exposed to air or free space, or can otherwise be any material region between the insulator surface of the wire and the conductive portion of the wire that meets the insulator portion of the wire, depending upon the relative differences in the properties (e.g., dielectric properties) of the insulator, air, and/or the conductor and further dependent on the frequency and propagation mode or modes of the guided wave.", "According to an example embodiment, the term “about” a wire or other transmission medium used in conjunction with a guided wave can include fundamental guided wave propagation modes such as a guided waves having a circular or substantially circular field distribution, a symmetrical electromagnetic field distribution (e.g., electric field, magnetic field, electromagnetic field, etc.)", "or other fundamental mode pattern at least partially around a wire or other transmission medium.", "In addition, when a guided wave propagates “about” a wire or other transmission medium, it can do so according to a guided wave propagation mode that includes not only the fundamental wave propagation modes (e.g., zero order modes), but additionally or alternatively non-fundamental wave propagation modes such as higher-order guided wave modes (e.g., 1st order modes, 2nd order modes, etc.", "), asymmetrical modes and/or other guided (e.g., surface) waves that have non-circular field distributions around a wire or other transmission medium.", "As used herein, the term “guided wave mode” refers to a guided wave propagation mode of a transmission medium, coupling device or other system component of a guided wave communication system.", "For example, such non-circular field distributions can be unilateral or multi-lateral with one or more axial lobes characterized by relatively higher field strength and/or one or more nulls or null regions characterized by relatively low-field strength, zero-field strength or substantially zero-field strength.", "Further, the field distribution can otherwise vary as a function of azimuthal orientation around the wire such that one or more angular regions around the wire have an electric or magnetic field strength (or combination thereof) that is higher than one or more other angular regions of azimuthal orientation, according to an example embodiment.", "It will be appreciated that the relative orientations or positions of the guided wave higher order modes or asymmetrical modes can vary as the guided wave travels along the wire.", "As used herein, the term “millimeter-wave” can refer to electromagnetic waves/signals that fall within the “millimeter-wave frequency band” of 30 GHz to 300 GHz.", "The term “microwave” can refer to electromagnetic waves/signals that fall within a “microwave frequency band” of 300 MHz to 300 GHz.", "The term “radio frequency” or “RF” can refer to electromagnetic waves/signals that fall within the “radio frequency band” of 10 kHz to 1 THz.", "It is appreciated that wireless signals, electrical signals, and guided electromagnetic waves as described in the subject disclosure can be configured to operate at any desirable frequency range, such as, for example, at frequencies within, above or below millimeter-wave and/or microwave frequency bands.", "In particular, when a coupling device or transmission medium includes a conductive element, the frequency of the guided electromagnetic waves that are carried by the coupling device and/or propagate along the transmission medium can be below the mean collision frequency of the electrons in the conductive element.", "Further, the frequency of the guided electromagnetic waves that are carried by the coupling device and/or propagate along the transmission medium can be a non-optical frequency, e.g.", "a radio frequency below the range of optical frequencies that begins at 1 THz.", "As used herein, the term “antenna” can refer to a device that is part of a transmitting or receiving system to transmit/radiate or receive wireless signals.", "Referring now to FIG.", "1, a block diagram 100 illustrating an example, non-limiting embodiment of a guided wave communications system is shown.", "In operation, a transmission device 101 receives one or more communication signals 110 from a communication network or other communications device that includes data and generates guided waves 120 to convey the data via the transmission medium 125 to the transmission device 102.The transmission device 102 receives the guided waves 120 and converts them to communication signals 112 that include the data for transmission to a communications network or other communications device.", "The guided waves 120 can be modulated to convey data via a modulation technique such as phase shift keying, frequency shift keying, quadrature amplitude modulation, amplitude modulation, multi-carrier modulation such as orthogonal frequency division multiplexing and via multiple access techniques such as frequency division multiplexing, time division multiplexing, code division multiplexing, multiplexing via differing wave propagation modes and via other modulation and access strategies.", "The communication network or networks can include a wireless communication network such as a mobile data network, a cellular voice and data network, a wireless local area network (e.g., WiFi or an IEEE 802 series of standards network), a satellite communications network, a personal area network or other wireless network.", "The communication network or networks can also include a wired communication network such as a telephone network, an Ethernet network, a local area network, a wide area network such as the Internet, a broadband access network, a cable network, a fiber optic network, or other wired network.", "The communication devices can include a network edge device, bridge device or home gateway, a set-top box, broadband modem, telephone adapter, access point, base station, or other fixed communication device, a mobile communication device such as an automotive gateway or automobile, laptop computer, tablet, smartphone, cellular telephone, or other communication device.", "In an example embodiment, the guided wave communication system 100 can operate in a bi-directional fashion where transmission device 102 receives one or more communication signals 112 from a communication network or device that includes other data and generates guided waves 122 to convey the other data via the transmission medium 125 to the transmission device 101.In this mode of operation, the transmission device 101 receives the guided waves 122 and converts them to communication signals 110 that include the other data for transmission to a communications network or device.", "The guided waves 122 can be modulated to convey data via a modulation technique such as phase shift keying, frequency shift keying, quadrature amplitude modulation, amplitude modulation, multi-carrier modulation such as orthogonal frequency division multiplexing and via multiple access techniques such as frequency division multiplexing, time division multiplexing, code division multiplexing, multiplexing via differing wave propagation modes and via other modulation and access strategies.", "The transmission medium 125 can include a cable having at least one inner portion surrounded by a dielectric material such as an insulator or other dielectric cover, coating or other dielectric material, the dielectric material having an outer surface and a corresponding circumference.", "In an example embodiment, the transmission medium 125 operates as a single-wire transmission line to guide the transmission of an electromagnetic wave.", "When the transmission medium 125 is implemented as a single wire transmission system, it can include a wire.", "The wire can be insulated or uninsulated, and single-stranded or multi-stranded (e.g., braided).", "In other embodiments, the transmission medium 125 can contain conductors of other shapes or configurations including wire bundles, cables, rods, rails, pipes.", "In addition, the transmission medium 125 can include non-conductors such as dielectric pipes, rods, rails, or other dielectric members; combinations of conductors and dielectric materials, conductors without dielectric materials or other guided wave transmission media.", "It should be noted that the transmission medium 125 can otherwise include any of the transmission media previously discussed.", "Further, as previously discussed, the guided waves 120 and 122 can be contrasted with radio transmissions over free space/air or conventional propagation of electrical power or signals through the conductor of a wire via an electrical circuit.", "In addition to the propagation of guided waves 120 and 122, the transmission medium 125 may optionally contain one or more wires that propagate electrical power or other communication signals in a conventional manner as a part of one or more electrical circuits.", "Referring now to FIG.", "2, a block diagram 200 illustrating an example, non-limiting embodiment of a transmission device is shown.", "The transmission device 101 or 102 includes a communications interface (Communications I/F) 205, a transceiver 210 and a coupler 220.In an example of operation, the communications interface 205 receives a communication signal 110 or 112 that includes data.", "In various embodiments, the communications interface 205 can include a wireless interface for receiving a wireless communication signal in accordance with a wireless standard protocol such as LTE or other cellular voice and data protocol, WiFi or an 802.11 protocol, WIMAX protocol, Ultra Wideband protocol, BLUETOOTH® protocol, ZIGBEE® protocol, a direct broadcast satellite (DBS) or other satellite communication protocol or other wireless protocol.", "In addition or in the alternative, the communications interface 205 includes a wired interface that operates in accordance with an Ethernet protocol, universal serial bus (USB) protocol, a data over cable service interface specification (DOCSIS) protocol, a digital subscriber line (DSL) protocol, a Firewire (IEEE 1394) protocol, or other wired protocol.", "In additional to standards-based protocols, the communications interface 205 can operate in conjunction with other wired or wireless protocol.", "In addition, the communications interface 205 can optionally operate in conjunction with a protocol stack that includes multiple protocol layers including a MAC protocol, transport protocol, application protocol, etc.", "In an example of operation, the transceiver 210 generates an electromagnetic wave based on the communication signal 110 or 112 to convey the data.", "The electromagnetic wave has at least one carrier frequency and at least one corresponding wavelength.", "The carrier frequency can be within a millimeter-wave frequency band of 30 GHz-300 GHz, such as 60 GHz or a carrier frequency in the range of 30-40 GHz or a lower frequency band of 300 MHz-30 GHz in the microwave frequency range such as 26-30 GHz, 11 GHz, 6 GHz or 3 GHz, but it will be appreciated that other carrier frequencies are possible in other embodiments.", "In one mode of operation, the transceiver 210 merely upconverts the communications signal or signals 110 or 112 for transmission of the electromagnetic signal in the microwave or millimeter-wave band as a guided electromagnetic wave that is guided by or bound to the transmission medium 125.In another mode of operation, the communications interface 205 either converts the communication signal 110 or 112 to a baseband or near baseband signal or extracts the data from the communication signal 110 or 112 and the transceiver 210 modulates a high-frequency carrier with the data, the baseband or near baseband signal for transmission.", "It should be appreciated that the transceiver 210 can modulate the data received via the communication signal 110 or 112 to preserve one or more data communication protocols of the communication signal 110 or 112 either by encapsulation in the payload of a different protocol or by simple frequency shifting.", "In the alternative, the transceiver 210 can otherwise translate the data received via the communication signal 110 or 112 to a protocol that is different from the data communication protocol or protocols of the communication signal 110 or 112.In an example of operation, the coupler 220 couples the electromagnetic wave to the transmission medium 125 as a guided electromagnetic wave to convey the communications signal or signals 110 or 112.While the prior description has focused on the operation of the transceiver 210 as a transmitter, the transceiver 210 can also operate to receive electromagnetic waves that convey other data from the single wire transmission medium via the coupler 220 and to generate communications signals 110 or 112, via communications interface 205 that includes the other data.", "Consider embodiments where an additional guided electromagnetic wave conveys other data that also propagates along the transmission medium 125.The coupler 220 can also couple this additional electromagnetic wave from the transmission medium 125 to the transceiver 210 for reception.", "The transmission device 101 or 102 includes an optional training controller 230.In an example embodiment, the training controller 230 is implemented by a standalone processor or a processor that is shared with one or more other components of the transmission device 101 or 102.The training controller 230 selects the carrier frequencies, modulation schemes and/or guided wave modes for the guided electromagnetic waves based on feedback data received by the transceiver 210 from at least one remote transmission device coupled to receive the guided electromagnetic wave.", "In an example embodiment, a guided electromagnetic wave transmitted by a remote transmission device 101 or 102 conveys data that also propagates along the transmission medium 125.The data from the remote transmission device 101 or 102 can be generated to include the feedback data.", "In operation, the coupler 220 also couples the guided electromagnetic wave from the transmission medium 125 and the transceiver receives the electromagnetic wave and processes the electromagnetic wave to extract the feedback data.", "In an example embodiment, the training controller 230 operates based on the feedback data to evaluate a plurality of candidate frequencies, modulation schemes and/or transmission modes to select a carrier frequency, modulation scheme and/or transmission mode to enhance performance, such as throughput, signal strength, reduce propagation loss, etc.", "Consider the following example: a transmission device 101 begins operation under control of the training controller 230 by sending a plurality of guided waves as test signals such as pilot waves or other test signals at a corresponding plurality of candidate frequencies and/or candidate modes directed to a remote transmission device 102 coupled to the transmission medium 125.The guided waves can include, in addition or in the alternative, test data.", "The test data can indicate the particular candidate frequency and/or guide-wave mode of the signal.", "In an embodiment, the training controller 230 at the remote transmission device 102 receives the test signals and/or test data from any of the guided waves that were properly received and determines the best candidate frequency and/or guided wave mode, a set of acceptable candidate frequencies and/or guided wave modes, or a rank ordering of candidate frequencies and/or guided wave modes.", "This selection of candidate frequenc(ies) or/and guided-mode(s) are generated by the training controller 230 based on one or more optimizing criteria such as received signal strength, bit error rate, packet error rate, signal to noise ratio, propagation loss, etc.", "The training controller 230 generates feedback data that indicates the selection of candidate frequenc(ies) or/and guided wave mode(s) and sends the feedback data to the transceiver 210 for transmission to the transmission device 101.The transmission device 101 and 102 can then communicate data with one another based on the selection of candidate frequenc(ies) or/and guided wave mode(s).", "In other embodiments, the guided electromagnetic waves that contain the test signals and/or test data are reflected back, repeated back or otherwise looped back by the remote transmission device 102 to the transmission device 101 for reception and analysis by the training controller 230 of the transmission device 101 that initiated these waves.", "For example, the transmission device 101 can send a signal to the remote transmission device 102 to initiate a test mode where a physical reflector is switched on the line, a termination impedance is changed to cause reflections, a loop back mode is switched on to couple electromagnetic waves back to the source transmission device 102, and/or a repeater mode is enabled to amplify and retransmit the electromagnetic waves back to the source transmission device 102.The training controller 230 at the source transmission device 102 receives the test signals and/or test data from any of the guided waves that were properly received and determines selection of candidate frequenc(ies) or/and guided wave mode(s).", "While the procedure above has been described in a start-up or initialization mode of operation, each transmission device 101 or 102 can send test signals, evaluate candidate frequencies or guided wave modes via non-test conditions such as normal transmissions or otherwise evaluate candidate frequencies or guided wave modes at other times or continuously as well.", "In an example embodiment, the communication protocol between the transmission devices 101 and 102 can include an on-request or periodic test mode where either full testing or more limited testing of a subset of candidate frequencies and guided wave modes are tested and evaluated.", "In other modes of operation, the re-entry into such a test mode can be triggered by a degradation of performance due to a disturbance, weather conditions, etc.", "In an example embodiment, the receiver bandwidth of the transceiver 210 is either sufficiently wide or swept to receive all candidate frequencies or can be selectively adjusted by the training controller 230 to a training mode where the receiver bandwidth of the transceiver 210 is sufficiently wide or swept to receive all candidate frequencies.", "Referring now to FIG.", "3, a graphical diagram 300 illustrating an example, non-limiting embodiment of an electromagnetic field distribution is shown.", "In this embodiment, a transmission medium 125 in air includes an inner conductor 301 and an insulating jacket 302 of dielectric material, as shown in cross section.", "The diagram 300 includes different gray-scales that represent differing electromagnetic field strengths generated by the propagation of the guided wave having an asymmetrical and non-fundamental guided wave mode.", "In particular, the electromagnetic field distribution corresponds to a modal “sweet spot” that enhances guided electromagnetic wave propagation along an insulated transmission medium and reduces end-to-end transmission loss.", "In this particular mode, electromagnetic waves are guided by the transmission medium 125 to propagate along an outer surface of the transmission medium—in this case, the outer surface of the insulating jacket 302.Electromagnetic waves are partially embedded in the insulator and partially radiating on the outer surface of the insulator.", "In this fashion, electromagnetic waves are “lightly” coupled to the insulator so as to enable electromagnetic wave propagation at long distances with low propagation loss.", "As shown, the guided wave has a field structure that lies primarily or substantially outside of the transmission medium 125 that serves to guide the electromagnetic waves.", "The regions inside the conductor 301 have little or no field.", "Likewise regions inside the insulating jacket 302 have low field strength.", "The majority of the electromagnetic field strength is distributed in the lobes 304 at the outer surface of the insulating jacket 302 and in close proximity thereof.", "The presence of an asymmetric guided wave mode is shown by the high electromagnetic field strengths at the top and bottom of the outer surface of the insulating jacket 302 (in the orientation of the diagram)—as opposed to very small field strengths on the other sides of the insulating jacket 302.The example shown corresponds to a 38 GHz electromagnetic wave guided by a wire with a diameter of 1.1 cm and a dielectric insulation of thickness of 0.36 cm.", "Because the electromagnetic wave is guided by the transmission medium 125 and the majority of the field strength is concentrated in the air outside of the insulating jacket 302 within a limited distance of the outer surface, the guided wave can propagate longitudinally down the transmission medium 125 with very low loss.", "In the example shown, this “limited distance” corresponds to a distance from the outer surface that is less than half the largest cross sectional dimension of the transmission medium 125.In this case, the largest cross sectional dimension of the wire corresponds to the overall diameter of 1.82 cm, however, this value can vary with the size and shape of the transmission medium 125.For example, should the transmission medium 125 be of a rectangular shape with a height of 0.3 cm and a width of 0.4 cm, the largest cross sectional dimension would be the diagonal of 0.5 cm and the corresponding limited distance would be 0.25 cm.", "The dimensions of the area containing the majority of the field strength also vary with the frequency, and in general, increase as carrier frequencies decrease.", "It should also be noted that the components of a guided wave communication system, such as couplers and transmission media can have their own cut-off frequencies for each guided wave mode.", "The cut-off frequency generally sets forth the lowest frequency that a particular guided wave mode is designed to be supported by that particular component.", "In an example embodiment, the particular asymmetric mode of propagation shown is induced on the transmission medium 125 by an electromagnetic wave having a frequency that falls within a limited range (such as Fc to 2Fc) of the lower cut-off frequency Fc for this particular asymmetric mode.", "The lower cut-off frequency Fc is particular to the characteristics of transmission medium 125.For embodiments as shown that include an inner conductor 301 surrounded by an insulating jacket 302, this cutoff frequency can vary based on the dimensions and properties of the insulating jacket 302 and potentially the dimensions and properties of the inner conductor 301 and can be determined experimentally to have a desired mode pattern.", "It should be noted however, that similar effects can be found for a hollow dielectric or insulator without an inner conductor.", "In this case, the cutoff frequency can vary based on the dimensions and properties of the hollow dielectric or insulator.", "At frequencies lower than the lower cut-off frequency, the asymmetric mode is difficult to induce in the transmission medium 125 and fails to propagate for all but trivial distances.", "As the frequency increases above the limited range of frequencies about the cut-off frequency, the asymmetric mode shifts more and more inward of the insulating jacket 302.At frequencies much larger than the cut-off frequency, the field strength is no longer concentrated outside of the insulating jacket, but primarily inside of the insulating jacket 302.While the transmission medium 125 provides strong guidance to the electromagnetic wave and propagation is still possible, ranges are more limited by increased losses due to propagation within the insulating jacket 302—as opposed to the surrounding air.", "Referring now to FIG.", "4, a graphical diagram 400 illustrating an example, non-limiting embodiment of an electromagnetic field distribution is shown.", "In particular, a cross section diagram 400, similar to FIG.", "3 is shown with common reference numerals used to refer to similar elements.", "The example shown corresponds to a 60 GHz wave guided by a wire with a diameter of 1.1 cm and a dielectric insulation of thickness of 0.36 cm.", "Because the frequency of the guided wave is above the limited range of the cut-off frequency of this particular asymmetric mode, much of the field strength has shifted inward of the insulating jacket 302.In particular, the field strength is concentrated primarily inside of the insulating jacket 302.While the transmission medium 125 provides strong guidance to the electromagnetic wave and propagation is still possible, ranges are more limited when compared with the embodiment of FIG.", "3, by increased losses due to propagation within the insulating jacket 302.Referring now to FIG.", "5A, a graphical diagram illustrating an example, non-limiting embodiment of a frequency response is shown.", "In particular, diagram 500 presents a graph of end-to-end loss (in dB) as a function of frequency, overlaid with electromagnetic field distributions 510, 520 and 530 at three points for a 200 cm insulated medium voltage wire.", "The boundary between the insulator and the surrounding air is represented by reference numeral 525 in each electromagnetic field distribution.", "As discussed in conjunction with FIG.", "3, an example of a desired asymmetric mode of propagation shown is induced on the transmission medium 125 by an electromagnetic wave having a frequency that falls within a limited range (such as Fc to 2Fc) of the lower cut-off frequency Fc of the transmission medium for this particular asymmetric mode.", "In particular, the electromagnetic field distribution 520 at 6 GHz falls within this modal “sweet spot” that enhances electromagnetic wave propagation along an insulated transmission medium and reduces end-to-end transmission loss.", "In this particular mode, guided waves are partially embedded in the insulator and partially radiating on the outer surface of the insulator.", "In this fashion, the electromagnetic waves are “lightly” coupled to the insulator so as to enable guided electromagnetic wave propagation at long distances with low propagation loss.", "At lower frequencies represented by the electromagnetic field distribution 510 at 3 GHz, the asymmetric mode radiates more heavily generating higher propagation losses.", "At higher frequencies represented by the electromagnetic field distribution 530 at 9 GHz, the asymmetric mode shifts more and more inward of the insulating jacket providing too much absorption, again generating higher propagation losses.", "Referring now to FIG.", "5B, a graphical diagram 550 illustrating example, non-limiting embodiments of a longitudinal cross-section of a transmission medium 125, such as an insulated wire, depicting fields of guided electromagnetic waves at various operating frequencies is shown.", "As shown in diagram 556, when the guided electromagnetic waves are at approximately the cutoff frequency (fc) corresponding to the modal “sweet spot”, the guided electromagnetic waves are loosely coupled to the insulated wire so that absorption is reduced, and the fields of the guided electromagnetic waves are bound sufficiently to reduce the amount radiated into the environment (e.g., air).", "Because absorption and radiation of the fields of the guided electromagnetic waves is low, propagation losses are consequently low, enabling the guided electromagnetic waves to propagate for longer distances.", "As shown in diagram 554, propagation losses increase when an operating frequency of the guide electromagnetic waves increases above about two-times the cutoff frequency (fc)—or as referred to, above the range of the “sweet spot”.", "More of the field strength of the electromagnetic wave is driven inside the insulating layer, increasing propagation losses.", "At frequencies much higher than the cutoff frequency (fc) the guided electromagnetic waves are strongly bound to the insulated wire as a result of the fields emitted by the guided electromagnetic waves being concentrated in the insulation layer of the wire, as shown in diagram 552.This in turn raises propagation losses further due to absorption of the guided electromagnetic waves by the insulation layer.", "Similarly, propagation losses increase when the operating frequency of the guided electromagnetic waves is substantially below the cutoff frequency (fc), as shown in diagram 558.At frequencies much lower than the cutoff frequency (fc) the guided electromagnetic waves are weakly (or nominally) bound to the insulated wire and thereby tend to radiate into the environment (e.g., air), which in turn, raises propagation losses due to radiation of the guided electromagnetic waves.", "Referring now to FIG.", "6, a graphical diagram 600 illustrating an example, non-limiting embodiment of an electromagnetic field distribution is shown.", "In this embodiment, a transmission medium 602 is a bare wire, as shown in cross section.", "The diagram 600 includes different gray-scales that represent differing electromagnetic field strengths generated by the propagation of a guided wave having a symmetrical and fundamental guided wave mode at a single carrier frequency.", "In this particular mode, electromagnetic waves are guided by the transmission medium 602 to propagate along an outer surface of the transmission medium—in this case, the outer surface of the bare wire.", "Electromagnetic waves are “lightly” coupled to the wire so as to enable electromagnetic wave propagation at long distances with low propagation loss.", "As shown, the guided wave has a field structure that lies substantially outside of the transmission medium 602 that serves to guide the electromagnetic waves.", "The regions inside the conductor of the transmission medium 602 have little or no field.", "Referring now to FIG.", "7, a block diagram 700 illustrating an example, non-limiting embodiment of an arc coupler is shown.", "In particular a coupling device is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.The coupling device includes an arc coupler 704 coupled to a transmitter circuit 712 and termination or damper 714.The arc coupler 704 can be made of a dielectric material, or other low-loss insulator (e.g., TEFLON®, polyethylene, etc.", "), or made of a conducting (e.g., metallic, non-metallic, etc.)", "material, or any combination of the foregoing materials.", "As shown, the arc coupler 704 operates as a waveguide and has a wave 706 propagating as a guided wave about a waveguide surface of the arc coupler 704.In the embodiment shown, at least a portion of the arc coupler 704 can be placed near a wire 702 or other transmission medium, (such as transmission medium 125), in order to facilitate coupling between the arc coupler 704 and the wire 702 or other transmission medium, as described herein to launch the guided wave 708 on the wire.", "The arc coupler 704 can be placed such that a portion of the curved arc coupler 704 is tangential to, and parallel or substantially parallel to the wire 702.The portion of the arc coupler 704 that is parallel to the wire can be an apex of the curve, or any point where a tangent of the curve is parallel to the wire 702.When the arc coupler 704 is positioned or placed thusly, the wave 706 travelling along the arc coupler 704 couples, at least in part, to the wire 702, and propagates as guided wave 708 around or about the wire surface of the wire 702 and longitudinally along the wire 702.The guided wave 708 can be characterized as a surface wave or other electromagnetic wave that is guided by or bound to the wire 702 or other transmission medium.", "A portion of the wave 706 that does not couple to the wire 702 propagates as a wave 710 along the arc coupler 704.It will be appreciated that the arc coupler 704 can be configured and arranged in a variety of positions in relation to the wire 702 to achieve a desired level of coupling or non-coupling of the wave 706 to the wire 702.For example, the curvature and/or length of the arc coupler 704 that is parallel or substantially parallel, as well as its separation distance (which can include zero separation distance in an embodiment), to the wire 702 can be varied without departing from example embodiments.", "Likewise, the arrangement of arc coupler 704 in relation to the wire 702 may be varied based upon considerations of the respective intrinsic characteristics (e.g., thickness, composition, electromagnetic properties, etc.)", "of the wire 702 and the arc coupler 704, as well as the characteristics (e.g., frequency, energy level, etc.)", "of the waves 706 and 708.The guided wave 708 stays parallel or substantially parallel to the wire 702, even as the wire 702 bends and flexes.", "Bends in the wire 702 can increase transmission losses, which are also dependent on wire diameters, frequency, and materials.", "If the dimensions of the arc coupler 704 are chosen for efficient power transfer, most of the power in the wave 706 is transferred to the wire 702, with little power remaining in wave 710.It will be appreciated that the guided wave 708 can still be multi-modal in nature (discussed herein), including having modes that are non-fundamental or asymmetric, while traveling along a path that is parallel or substantially parallel to the wire 702, with or without a fundamental transmission mode.", "In an embodiment, non-fundamental or asymmetric modes can be utilized to minimize transmission losses and/or obtain increased propagation distances.", "It is noted that the term “parallel” is generally a geometric construct which often is not exactly achievable in real systems.", "Accordingly, the term “parallel” as utilized in the subject disclosure represents an approximation rather than an exact configuration when used to describe embodiments disclosed in the subject disclosure.", "In an embodiment, “substantially parallel” can include approximations that are within 30 degrees of true parallel in all dimensions.", "In an embodiment, the wave 706 can exhibit one or more wave propagation modes.", "The arc coupler modes can be dependent on the shape and/or design of the coupler 704.The one or more arc coupler modes of wave 706 can generate, influence, or impact one or more wave propagation modes of the guided wave 708 propagating along wire 702.It should be particularly noted however that the guided wave modes present in the guided wave 706 may be the same or different from the guided wave modes of the guided wave 708.In this fashion, one or more guided wave modes of the guided wave 706 may not be transferred to the guided wave 708, and further one or more guided wave modes of guided wave 708 may not have been present in guided wave 706.It should also be noted that the cut-off frequency of the arc coupler 704 for a particular guided wave mode may be different than the cutoff frequency of the wire 702 or other transmission medium for that same mode.", "For example, while the wire 702 or other transmission medium may be operated slightly above its cutoff frequency for a particular guided wave mode, the arc coupler 704 may be operated well above its cut-off frequency for that same mode for low loss, slightly below its cut-off frequency for that same mode to, for example, induce greater coupling and power transfer, or some other point in relation to the arc coupler's cutoff frequency for that mode.", "In an embodiment, the wave propagation modes on the wire 702 can be similar to the arc coupler modes since both waves 706 and 708 propagate about the outside of the arc coupler 704 and wire 702 respectively.", "In some embodiments, as the wave 706 couples to the wire 702, the modes can change form, or new modes can be created or generated, due to the coupling between the arc coupler 704 and the wire 702.For example, differences in size, material, and/or impedances of the arc coupler 704 and wire 702 may create additional modes not present in the arc coupler modes and/or suppress some of the arc coupler modes.", "The wave propagation modes can comprise the fundamental transverse electromagnetic mode (Quasi-TEM00), where only small electric and/or magnetic fields extend in the direction of propagation, and the electric and magnetic fields extend radially outwards while the guided wave propagates along the wire.", "This guided wave mode can be donut shaped, where few of the electromagnetic fields exist within the arc coupler 704 or wire 702.Waves 706 and 708 can comprise a fundamental TEM mode where the fields extend radially outwards, and also comprise other, non-fundamental (e.g., asymmetric, higher-level, etc.)", "modes.", "While particular wave propagation modes are discussed above, other wave propagation modes are likewise possible such as transverse electric (TE) and transverse magnetic (TM) modes, based on the frequencies employed, the design of the arc coupler 704, the dimensions and composition of the wire 702, as well as its surface characteristics, its insulation if present, the electromagnetic properties of the surrounding environment, etc.", "It should be noted that, depending on the frequency, the electrical and physical characteristics of the wire 702 and the particular wave propagation modes that are generated, guided wave 708 can travel along the conductive surface of an oxidized uninsulated wire, an unoxidized uninsulated wire, an insulated wire and/or along the insulating surface of an insulated wire.", "In an embodiment, a diameter of the arc coupler 704 is smaller than the diameter of the wire 702.For the millimeter-band wavelength being used, the arc coupler 704 supports a single waveguide mode that makes up wave 706.This single waveguide mode can change as it couples to the wire 702 as guided wave 708.If the arc coupler 704 were larger, more than one waveguide mode can be supported, but these additional waveguide modes may not couple to the wire 702 as efficiently, and higher coupling losses can result.", "However, in some alternative embodiments, the diameter of the arc coupler 704 can be equal to or larger than the diameter of the wire 702, for example, where higher coupling losses are desirable or when used in conjunction with other techniques to otherwise reduce coupling losses (e.g., impedance matching with tapering, etc.).", "In an embodiment, the wavelength of the waves 706 and 708 are comparable in size, or smaller than a circumference of the arc coupler 704 and the wire 702.In an example, if the wire 702 has a diameter of 0.5 cm, and a corresponding circumference of around 1.5 cm, the wavelength of the transmission is around 1.5 cm or less, corresponding to a frequency of 70 GHz or greater.", "In another embodiment, a suitable frequency of the transmission and the carrier-wave signal is in the range of 30-100 GHz, perhaps around 30-60 GHz, and around 38 GHz in one example.", "In an embodiment, when the circumference of the arc coupler 704 and wire 702 is comparable in size to, or greater, than a wavelength of the transmission, the waves 706 and 708 can exhibit multiple wave propagation modes including fundamental and/or non-fundamental (symmetric and/or asymmetric) modes that propagate over sufficient distances to support various communication systems described herein.", "The waves 706 and 708 can therefore comprise more than one type of electric and magnetic field configuration.", "In an embodiment, as the guided wave 708 propagates down the wire 702, the electrical and magnetic field configurations will remain the same from end to end of the wire 702.In other embodiments, as the guided wave 708 encounters interference (distortion or obstructions) or loses energy due to transmission losses or scattering, the electric and magnetic field configurations can change as the guided wave 708 propagates down wire 702.In an embodiment, the arc coupler 704 can be composed of nylon, TEFLON®, polyethylene, a polyamide, or other plastics.", "In other embodiments, other dielectric materials are possible.", "The wire surface of wire 702 can be metallic with either a bare metallic surface, or can be insulated using plastic, dielectric, insulator or other coating, jacket or sheathing.", "In an embodiment, a dielectric or otherwise non-conducting/insulated waveguide can be paired with either a bare/metallic wire or insulated wire.", "In other embodiments, a metallic and/or conductive waveguide can be paired with a bare/metallic wire or insulated wire.", "In an embodiment, an oxidation layer on the bare metallic surface of the wire 702 (e.g., resulting from exposure of the bare metallic surface to oxygen/air) can also provide insulating or dielectric properties similar to those provided by some insulators or sheathings.", "It is noted that the graphical representations of waves 706, 708 and 710 are presented merely to illustrate the principles that wave 706 induces or otherwise launches a guided wave 708 on a wire 702 that operates, for example, as a single wire transmission line.", "Wave 710 represents the portion of wave 706 that remains on the arc coupler 704 after the generation of guided wave 708.The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on the frequencies employed, the particular wave propagation mode or modes, the design of the arc coupler 704, the dimensions and composition of the wire 702, as well as its surface characteristics, its optional insulation, the electromagnetic properties of the surrounding environment, etc.", "It is noted that arc coupler 704 can include a termination circuit or damper 714 at the end of the arc coupler 704 that can absorb leftover radiation or energy from wave 710.The termination circuit or damper 714 can prevent and/or minimize the leftover radiation or energy from wave 710 reflecting back toward transmitter circuit 712.In an embodiment, the termination circuit or damper 714 can include termination resistors, and/or other components that perform impedance matching to attenuate reflection.", "In some embodiments, if the coupling efficiencies are high enough, and/or wave 710 is sufficiently small, it may not be necessary to use a termination circuit or damper 714.For the sake of simplicity, these transmitter 712 and termination circuits or dampers 714 may not be depicted in the other figures, but in those embodiments, transmitter and termination circuits or dampers may possibly be used.", "Further, while a single arc coupler 704 is presented that generates a single guided wave 708, multiple arc couplers 704 placed at different points along the wire 702 and/or at different azimuthal orientations about the wire can be employed to generate and receive multiple guided waves 708 at the same or different frequencies, at the same or different phases, at the same or different wave propagation modes.", "FIG.", "8, a block diagram 800 illustrating an example, non-limiting embodiment of an arc coupler is shown.", "In the embodiment shown, at least a portion of the coupler 704 can be placed near a wire 702 or other transmission medium, (such as transmission medium 125), in order to facilitate coupling between the arc coupler 704 and the wire 702 or other transmission medium, to extract a portion of the guided wave 806 as a guided wave 808 as described herein.", "The arc coupler 704 can be placed such that a portion of the curved arc coupler 704 is tangential to, and parallel or substantially parallel to the wire 702.The portion of the arc coupler 704 that is parallel to the wire can be an apex of the curve, or any point where a tangent of the curve is parallel to the wire 702.When the arc coupler 704 is positioned or placed thusly, the wave 806 travelling along the wire 702 couples, at least in part, to the arc coupler 704, and propagates as guided wave 808 along the arc coupler 704 to a receiving device (not expressly shown).", "A portion of the wave 806 that does not couple to the arc coupler propagates as wave 810 along the wire 702 or other transmission medium.", "In an embodiment, the wave 806 can exhibit one or more wave propagation modes.", "The arc coupler modes can be dependent on the shape and/or design of the coupler 704.The one or more modes of guided wave 806 can generate, influence, or impact one or more guide-wave modes of the guided wave 808 propagating along the arc coupler 704.It should be particularly noted however that the guided wave modes present in the guided wave 806 may be the same or different from the guided wave modes of the guided wave 808.In this fashion, one or more guided wave modes of the guided wave 806 may not be transferred to the guided wave 808, and further one or more guided wave modes of guided wave 808 may not have been present in guided wave 806.Referring now to FIG.", "9A, a block diagram 900 illustrating an example, non-limiting embodiment of a stub coupler is shown.", "In particular a coupling device that includes stub coupler 904 is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.The stub coupler 904 can be made of a dielectric material, or other low-loss insulator (e.g., TEFLON®, polyethylene and etc.", "), or made of a conducting (e.g., metallic, non-metallic, etc.)", "material, or any combination of the foregoing materials.", "As shown, the stub coupler 904 operates as a waveguide and has a wave 906 propagating as a guided wave about a waveguide surface of the stub coupler 904.In the embodiment shown, at least a portion of the stub coupler 904 can be placed near a wire 702 or other transmission medium, (such as transmission medium 125), in order to facilitate coupling between the stub coupler 904 and the wire 702 or other transmission medium, as described herein to launch the guided wave 908 on the wire.", "In an embodiment, the stub coupler 904 is curved, and an end of the stub coupler 904 can be tied, fastened, or otherwise mechanically coupled to a wire 702.When the end of the stub coupler 904 is fastened to the wire 702, the end of the stub coupler 904 is parallel or substantially parallel to the wire 702.Alternatively, another portion of the dielectric waveguide beyond an end can be fastened or coupled to wire 702 such that the fastened or coupled portion is parallel or substantially parallel to the wire 702.The fastener 910 can be a nylon cable tie or other type of non-conducting/dielectric material that is either separate from the stub coupler 904 or constructed as an integrated component of the stub coupler 904.The stub coupler 904 can be adjacent to the wire 702 without surrounding the wire 702.Like the arc coupler 704 described in conjunction with FIG.", "7, when the stub coupler 904 is placed with the end parallel to the wire 702, the guided wave 906 travelling along the stub coupler 904 couples to the wire 702, and propagates as guided wave 908 about the wire surface of the wire 702.In an example embodiment, the guided wave 908 can be characterized as a surface wave or other electromagnetic wave.", "It is noted that the graphical representations of waves 906 and 908 are presented merely to illustrate the principles that wave 906 induces or otherwise launches a guided wave 908 on a wire 702 that operates, for example, as a single wire transmission line.", "The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on one or more of the shape and/or design of the coupler, the relative position of the dielectric waveguide to the wire, the frequencies employed, the design of the stub coupler 904, the dimensions and composition of the wire 702, as well as its surface characteristics, its optional insulation, the electromagnetic properties of the surrounding environment, etc.", "In an embodiment, an end of stub coupler 904 can taper towards the wire 702 in order to increase coupling efficiencies.", "Indeed, the tapering of the end of the stub coupler 904 can provide impedance matching to the wire 702 and reduce reflections, according to an example embodiment of the subject disclosure.", "For example, an end of the stub coupler 904 can be gradually tapered in order to obtain a desired level of coupling between waves 906 and 908 as illustrated in FIG.", "9A.", "In an embodiment, the fastener 910 can be placed such that there is a short length of the stub coupler 904 between the fastener 910 and an end of the stub coupler 904.Maximum coupling efficiencies are realized in this embodiment when the length of the end of the stub coupler 904 that is beyond the fastener 910 is at least several wavelengths long for whatever frequency is being transmitted.", "Turning now to FIG.", "9B, a diagram 950 illustrating an example, non-limiting embodiment of an electromagnetic distribution in accordance with various aspects described herein is shown.", "In particular, an electromagnetic distribution is presented in two dimensions for a transmission device that includes coupler 952, shown in an example stub coupler constructed of a dielectric material.", "The coupler 952 couples an electromagnetic wave for propagation as a guided wave along an outer surface of a wire 702 or other transmission medium.", "The coupler 952 guides the electromagnetic wave to a junction at x0 via a symmetrical guided wave mode.", "While some of the energy of the electromagnetic wave that propagates along the coupler 952 is outside of the coupler 952, the majority of the energy of this electromagnetic wave is contained within the coupler 952.The junction at x0 couples the electromagnetic wave to the wire 702 or other transmission medium at an azimuthal angle corresponding to the bottom of the transmission medium.", "This coupling induces an electromagnetic wave that is guided to propagate along the outer surface of the wire 702 or other transmission medium via at least one guided wave mode in direction 956.The majority of the energy of the guided electromagnetic wave is outside or, but in close proximity to the outer surface of the wire 702 or other transmission medium.", "In the example shown, the junction at x0 forms an electromagnetic wave that propagates via both a symmetrical mode and at least one asymmetrical surface mode, such as the first order mode presented in conjunction with FIG.", "3, that skims the surface of the wire 702 or other transmission medium.", "It is noted that the graphical representations of guided waves are presented merely to illustrate an example of guided wave coupling and propagation.", "The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on the frequencies employed, the design and/or configuration of the coupler 952, the dimensions and composition of the wire 702 or other transmission medium, as well as its surface characteristics, its insulation if present, the electromagnetic properties of the surrounding environment, etc.", "Turning now to FIG.", "10A, illustrated is a block diagram 1000 of an example, non-limiting embodiment of a coupler and transceiver system in accordance with various aspects described herein.", "The system is an example of transmission device 101 or 102.In particular, the communications interface (COMM I/F) 1008 is an example of communications interface 205, the stub coupler 1002 is an example of coupler 220, and the transmitter/receiver device 1006, diplexer 1016, power amplifier 1014, low noise amplifier 1018, frequency mixers 1010 and 1020 and local oscillator 1012 collectively form an example of transceiver 210.In operation, the transmitter/receiver device 1006 launches and receives waves (e.g., guided wave 1004 onto stub coupler 1002).", "The guided waves 1004 can be used to transport signals received from and sent to a host device, base station, mobile devices, a building or other device by way of a communications interface 1008.The communications interface 1008 can be an integral part of system 1000.Alternatively, the communications interface 1008 can be tethered to system 1000.The communications interface 1008 can comprise a wireless interface for interfacing to the host device, base station, mobile devices, a building or other device utilizing any of various wireless signaling protocols (e.g., LTE, WiFi, WiMAX, IEEE 802 series of standards, etc.)", "including an infrared protocol such as an infrared data association (IrDA) protocol or other line of sight optical protocol.", "The communications interface 1008 can also comprise a wired interface such as a fiber optic line, coaxial cable, twisted pair, category 5 (CAT-5) cable or other suitable wired or optical mediums for communicating with the host device, base station, mobile devices, a building or other device via a protocol such as an Ethernet protocol, universal serial bus (USB) protocol, a data over cable service interface specification (DOCSIS) protocol, a digital subscriber line (DSL) protocol, a Firewire (IEEE 1394) protocol, or other wired or optical protocol.", "For embodiments where system 1000 functions as a repeater, the communications interface 1008 may not be necessary.", "The output signals (e.g., Tx) of the communications interface 1008 can be combined with a carrier wave (e.g., millimeter-wave carrier wave) generated by a local oscillator 1012 at frequency mixer 1010.Frequency mixer 1010 can use heterodyning techniques or other frequency shifting techniques to frequency shift the output signals from communications interface 1008.For example, signals sent to and from the communications interface 1008 can be modulated signals such as orthogonal frequency division multiplexed (OFDM) signals formatted in accordance with a Long-Term Evolution (LTE) wireless protocol or other wireless 3G, 4G, 5G or higher voice and data protocol, a ZIGBEE®, WIMAX, UltraWideband or IEEE 802.11 wireless protocol; a wired protocol such as an Ethernet protocol, universal serial bus (USB) protocol, a data over cable service interface specification (DOCSIS) protocol, a digital subscriber line (DSL) protocol, a Firewire (IEEE 1394) protocol or other wired or wireless protocol.", "In an example embodiment, this frequency conversion can be done in the analog domain, and as a result, the frequency shifting can be done without regard to the type of communications protocol used by a base station, mobile devices, or in-building devices.", "As new communications technologies are developed, the communications interface 1008 can be upgraded (e.g., updated with software, firmware, and/or hardware) or replaced and the frequency shifting and transmission apparatus can remain, simplifying upgrades.", "The carrier wave can then be sent to a power amplifier (“PA”) 1014 and can be transmitted via the transmitter receiver device 1006 via the diplexer 1016.Signals received from the transmitter/receiver device 1006 that are directed towards the communications interface 1008 can be separated from other signals via diplexer 1016.The received signal can then be sent to low noise amplifier (“LNA”) 1018 for amplification.", "A frequency mixer 1020, with help from local oscillator 1012 can downshift the received signal (which is in the millimeter-wave band or around 38 GHz in some embodiments) to the native frequency.", "The communications interface 1008 can then receive the transmission at an input port (Rx).", "In an embodiment, transmitter/receiver device 1006 can include a cylindrical or non-cylindrical metal (which, for example, can be hollow in an embodiment, but not necessarily drawn to scale) or other conducting or non-conducting waveguide and an end of the stub coupler 1002 can be placed in or in proximity to the waveguide or the transmitter/receiver device 1006 such that when the transmitter/receiver device 1006 generates a transmission, the guided wave couples to stub coupler 1002 and propagates as a guided wave 1004 about the waveguide surface of the stub coupler 1002.In some embodiments, the guided wave 1004 can propagate in part on the outer surface of the stub coupler 1002 and in part inside the stub coupler 1002.In other embodiments, the guided wave 1004 can propagate substantially or completely on the outer surface of the stub coupler 1002.In yet other embodiments, the guided wave 1004 can propagate substantially or completely inside the stub coupler 1002.In this latter embodiment, the guided wave 1004 can radiate at an end of the stub coupler 1002 (such as the tapered end shown in FIG.", "4) for coupling to a transmission medium such as a wire 702 of FIG.", "7.Similarly, if guided wave 1004 is incoming (coupled to the stub coupler 1002 from a wire 702), guided wave 1004 then enters the transmitter/receiver device 1006 and couples to the cylindrical waveguide or conducting waveguide.", "While transmitter/receiver device 1006 is shown to include a separate waveguide—an antenna, cavity resonator, klystron, magnetron, travelling wave tube, or other radiating element can be employed to induce a guided wave on the coupler 1002, with or without the separate waveguide.", "In an embodiment, stub coupler 1002 can be wholly constructed of a dielectric material (or another suitable insulating material), without any metallic or otherwise conducting materials therein.", "Stub coupler 1002 can be composed of nylon, TEFLON®, polyethylene, a polyamide, other plastics, or other materials that are non-conducting and suitable for facilitating transmission of electromagnetic waves at least in part on an outer surface of such materials.", "In another embodiment, stub coupler 1002 can include a core that is conducting/metallic, and have an exterior dielectric surface.", "Similarly, a transmission medium that couples to the stub coupler 1002 for propagating electromagnetic waves induced by the stub coupler 1002 or for supplying electromagnetic waves to the stub coupler 1002 can, in addition to being a bare or insulated wire, be wholly constructed of a dielectric material (or another suitable insulating material), without any metallic or otherwise conducting materials therein.", "It is noted that although FIG.", "10A shows that the opening of transmitter receiver device 1006 is much wider than the stub coupler 1002, this is not to scale, and that in other embodiments the width of the stub coupler 1002 is comparable or slightly smaller than the opening of the hollow waveguide.", "It is also not shown, but in an embodiment, an end of the coupler 1002 that is inserted into the transmitter/receiver device 1006 tapers down in order to reduce reflection and increase coupling efficiencies.", "Before coupling to the stub coupler 1002, the one or more waveguide modes of the guided wave generated by the transmitter/receiver device 1006 can couple to the stub coupler 1002 to induce one or more wave propagation modes of the guided wave 1004.The wave propagation modes of the guided wave 1004 can be different than the hollow metal waveguide modes due to the different characteristics of the hollow metal waveguide and the dielectric waveguide.", "For instance, wave propagation modes of the guided wave 1004 can comprise the fundamental transverse electromagnetic mode (Quasi-TEM00), where only small electrical and/or magnetic fields extend in the direction of propagation, and the electric and magnetic fields extend radially outwards from the stub coupler 1002 while the guided waves propagate along the stub coupler 1002.The fundamental transverse electromagnetic mode wave propagation mode may or may not exist inside a waveguide that is hollow.", "Therefore, the hollow metal waveguide modes that are used by transmitter/receiver device 1006 are waveguide modes that can couple effectively and efficiently to wave propagation modes of stub coupler 1002.It will be appreciated that other constructs or combinations of the transmitter/receiver device 1006 and stub coupler 1002 are possible.", "For example, a stub coupler 1002′ can be placed tangentially or in parallel (with or without a gap) with respect to an outer surface of the hollow metal waveguide of the transmitter/receiver device 1006′ (corresponding circuitry not shown) as depicted by reference 1000′ of FIG.", "10B.", "In another embodiment, not shown by reference 1000′, the stub coupler 1002′ can be placed inside the hollow metal waveguide of the transmitter/receiver device 1006′ without an axis of the stub coupler 1002′ being coaxially aligned with an axis of the hollow metal waveguide of the transmitter/receiver device 1006′.", "In either of these embodiments, the guided wave generated by the transmitter/receiver device 1006′ can couple to a surface of the stub coupler 1002′ to induce one or more wave propagation modes of the guided wave 1004′ on the stub coupler 1002′ including a fundamental mode (e.g., a symmetric mode) and/or a non-fundamental mode (e.g., asymmetric mode).", "In one embodiment, the guided wave 1004′ can propagate in part on the outer surface of the stub coupler 1002′ and in part inside the stub coupler 1002′.", "In another embodiment, the guided wave 1004′ can propagate substantially or completely on the outer surface of the stub coupler 1002′.", "In yet other embodiments, the guided wave 1004′ can propagate substantially or completely inside the stub coupler 1002′.", "In this latter embodiment, the guided wave 1004′ can radiate at an end of the stub coupler 1002′ (such as the tapered end shown in FIG.", "9) for coupling to a transmission medium such as a wire 702 of FIG.", "9.It will be further appreciated that other constructs the transmitter/receiver device 1006 are possible.", "For example, a hollow metal waveguide of a transmitter/receiver device 1006″ (corresponding circuitry not shown), depicted in FIG.", "10B as reference 1000″, can be placed tangentially or in parallel (with or without a gap) with respect to an outer surface of a transmission medium such as the wire 702 of FIG.", "4 without the use of the stub coupler 1002.In this embodiment, the guided wave generated by the transmitter/receiver device 1006″ can couple to a surface of the wire 702 to induce one or more wave propagation modes of a guided wave 908 on the wire 702 including a fundamental mode (e.g., a symmetric mode) and/or a non-fundamental mode (e.g., asymmetric mode).", "In another embodiment depicted in FIG.", "10B reference 1000″′, the wire 702 can be positioned inside a hollow metal waveguide of a transmitter/receiver device 1006″′ (corresponding circuitry not shown) so that an axis of the wire 702 is coaxially (or not coaxially) aligned with an axis of the hollow metal waveguide without the use of the stub coupler 1002 (not shown).", "In this embodiment, the guided wave generated by the transmitter/receiver device 1006′ can couple to a surface of the wire 702 to induce one or more wave propagation modes of a guided wave 908 on the wire including a fundamental mode (e.g., a symmetric mode) and/or a non-fundamental mode (e.g., asymmetric mode).", "In the embodiments of 1000″ and 1000″′, for a wire 702 having an insulated outer surface, the guided wave 908 can propagate in part on the outer surface of the insulator and in part inside the insulator.", "In embodiments, the guided wave 908 can propagate substantially or completely on the outer surface of the insulator, or substantially or completely inside the insulator.", "In the embodiments of 1000″ and 1000″′, for a wire 702 that is a bare conductor, the guided wave 908 can propagate in part on the outer surface of the conductor and in part inside the conductor.", "In another embodiment, the guided wave 908 can propagate substantially or completely on the outer surface of the conductor.", "Referring now to FIG.", "11, a block diagram 1100 illustrating an example, non-limiting embodiment of a dual stub coupler is shown.", "In particular, a dual coupler design is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.In an embodiment, two or more couplers (such as the stub couplers 1104 and 1106) can be positioned around a wire 1102 in order to receive guided wave 1108.In an embodiment, one coupler is enough to receive the guided wave 1108.In that case, guided wave 1108 couples to coupler 1104 and propagates as guided wave 1110.If the field structure of the guided wave 1108 oscillates or undulates around the wire 1102 due to the particular guided wave mode(s) or various outside factors, then coupler 1106 can be placed such that guided wave 1108 couples to coupler 1106.In some embodiments, four or more couplers can be placed around a portion of the wire 1102, e.g., at 90 degrees or another spacing with respect to each other, in order to receive guided waves that may oscillate or rotate around the wire 1102, that have been induced at different azimuthal orientations or that have non-fundamental or higher order modes that, for example, have lobes and/or nulls or other asymmetries that are orientation dependent.", "However, it will be appreciated that there may be less than or more than four couplers placed around a portion of the wire 1102 without departing from example embodiments.", "It should be noted that while couplers 1106 and 1104 are illustrated as stub couplers, any other of the coupler designs described herein including arc couplers, antenna or horn couplers, magnetic couplers, etc., could likewise be used.", "It will also be appreciated that while some example embodiments have presented a plurality of couplers around at least a portion of a wire 1102, this plurality of couplers can also be considered as part of a single coupler system having multiple coupler subcomponents.", "For example, two or more couplers can be manufactured as single system that can be installed around a wire in a single installation such that the couplers are either pre-positioned or adjustable relative to each other (either manually or automatically with a controllable mechanism such as a motor or other actuator) in accordance with the single system.", "Receivers coupled to couplers 1106 and 1104 can use diversity combining to combine signals received from both couplers 1106 and 1104 in order to maximize the signal quality.", "In other embodiments, if one or the other of the couplers 1104 and 1106 receive a transmission that is above a predetermined threshold, receivers can use selection diversity when deciding which signal to use.", "Further, while reception by a plurality of couplers 1106 and 1104 is illustrated, transmission by couplers 1106 and 1104 in the same configuration can likewise take place.", "In particular, a wide range of multi-input multi-output (MIMO) transmission and reception techniques can be employed for transmissions where a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1 includes multiple transceivers and multiple couplers.", "It is noted that the graphical representations of waves 1108 and 1110 are presented merely to illustrate the principles that guided wave 1108 induces or otherwise launches a wave 1110 on a coupler 1104.The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on the frequencies employed, the design of the coupler 1104, the dimensions and composition of the wire 1102, as well as its surface characteristics, its insulation if any, the electromagnetic properties of the surrounding environment, etc.", "Referring now to FIG.", "12, a block diagram 1200 illustrating an example, non- limiting embodiment of a repeater system is shown.", "In particular, a repeater device 1210 is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.In this system, two couplers 1204 and 1214 can be placed near a wire 1202 or other transmission medium such that guided waves 1205 propagating along the wire 1202 are extracted by coupler 1204 as wave 1206 (e.g.", "as a guided wave), and then are boosted or repeated by repeater device 1210 and launched as a wave 1216 (e.g.", "as a guided wave) onto coupler 1214.The wave 1216 can then be launched on the wire 1202 and continue to propagate along the wire 1202 as a guided wave 1217.In an embodiment, the repeater device 1210 can receive at least a portion of the power utilized for boosting or repeating through magnetic coupling with the wire 1202, for example, when the wire 1202 is a power line or otherwise contains a power-carrying conductor.", "It should be noted that while couplers 1204 and 1214 are illustrated as stub couplers, any other of the coupler designs described herein including arc couplers, antenna or horn couplers, magnetic couplers, or the like, could likewise be used.", "In some embodiments, repeater device 1210 can repeat the transmission associated with wave 1206, and in other embodiments, repeater device 1210 can include a communications interface (COMM I/F) 205 that extracts data or other signals from the wave 1206 for supplying such data or signals to another network and/or one or more other devices as communication signals 110 or 112 and/or receiving communication signals 110 or 112 from another network and/or one or more other devices and launch guided wave 1216 having embedded therein the received communication signals 110 or 112.In a repeater configuration, receiver waveguide 1208 can receive the wave 1206 from the coupler 1204 and transmitter waveguide 1212 can launch guided wave 1216 onto coupler 1214 as guided wave 1217.Between receiver waveguide 1208 and transmitter waveguide 1212, the signal embedded in guided wave 1206 and/or the guided wave 1216 itself can be amplified to correct for signal loss and other inefficiencies associated with guided wave communications or the signal can be received and processed to extract the data contained therein and regenerated for transmission.", "In an embodiment, the receiver waveguide 1208 can be configured to extract data from the signal, process the data to correct for data errors utilizing for example error correcting codes, and regenerate an updated signal with the corrected data.", "The transmitter waveguide 1212 can then transmit guided wave 1216 with the updated signal embedded therein.", "In an embodiment, a signal embedded in guided wave 1206 can be extracted from the transmission and processed for communication with another network and/or one or more other devices via communications interface 205 as communication signals 110 or 112.Similarly, communication signals 110 or 112 received by the communications interface 205 can be inserted into a transmission of guided wave 1216 that is generated and launched onto coupler 1214 by transmitter waveguide 1212.It is noted that although FIG.", "12 shows guided wave transmissions 1206 and 1216 entering from the left and exiting to the right respectively, this is merely a simplification and is not intended to be limiting.", "In other embodiments, receiver waveguide 1208 and transmitter waveguide 1212 can also function as transmitters and receivers respectively, allowing the repeater device 1210 to be bi-directional.", "In an embodiment, repeater device 1210 can be placed at locations where there are discontinuities or obstacles on the wire 1202 or other transmission medium.", "In the case where the wire 1202 is a power line, these obstacles can include transformers, connections, utility poles, and other such power line devices.", "The repeater device 1210 can help the guided (e.g., surface) waves jump over these obstacles on the line and boost the transmission power at the same time.", "In other embodiments, a coupler can be used to jump over the obstacle without the use of a repeater device.", "In that embodiment, both ends of the coupler can be tied or fastened to the wire, thus providing a path for the guided wave to travel without being blocked by the obstacle.", "Turning now to FIG.", "13, illustrated is a block diagram 1300 of an example, non-limiting embodiment of a bidirectional repeater in accordance with various aspects described herein.", "In particular, a bidirectional repeater device 1306 is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.It should be noted that while the couplers are illustrated as stub couplers, any other of the coupler designs described herein including arc couplers, antenna or horn couplers, magnetic couplers, or the like, could likewise be used.", "The bidirectional repeater 1306 can employ diversity paths in the case of when two or more wires or other transmission media are present.", "Since guided wave transmissions have different transmission efficiencies and coupling efficiencies for transmission medium of different types such as insulated wires, un-insulated wires or other types of transmission media and further, if exposed to the elements, can be affected by weather, and other atmospheric conditions, it can be advantageous to selectively transmit on different transmission media at certain times.", "In various embodiments, the various transmission media can be designated as a primary, secondary, tertiary, etc.", "whether or not such designation indicates a preference of one transmission medium over another.", "In the embodiment shown, the transmission media include an insulated or uninsulated wire 1302 and an insulated or uninsulated wire 1304 (referred to herein as wires 1302 and 1304, respectively).", "The repeater device 1306 uses a receiver coupler 1308 to receive a guided wave traveling along wire 1302 and repeats the transmission using transmitter waveguide 1310 as a guided wave along wire 1304.In other embodiments, repeater device 1306 can switch from the wire 1304 to the wire 1302, or can repeat the transmissions along the same paths.", "Repeater device 1306 can include sensors, or be in communication with sensors (or a network management system 1601 depicted in FIG.", "16A) that indicate conditions that can affect the transmission.", "Based on the feedback received from the sensors, the repeater device 1306 can make the determination about whether to keep the transmission along the same wire, or transfer the transmission to the other wire.", "Turning now to FIG.", "14, illustrated is a block diagram 1400 illustrating an example, non-limiting embodiment of a bidirectional repeater system.", "In particular, a bidirectional repeater system is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.The bidirectional repeater system includes waveguide coupling devices 1402 and 1404 that receive and transmit transmissions from other coupling devices located in a distributed antenna system or backhaul system.", "In various embodiments, waveguide coupling device 1402 can receive a transmission from another waveguide coupling device, wherein the transmission has a plurality of subcarriers.", "Diplexer 1406 can separate the transmission from other transmissions, and direct the transmission to low-noise amplifier (“LNA”) 1408.A frequency mixer 1428, with help from a local oscillator 1412, can downshift the transmission (which is in the millimeter-wave band or around 38 GHz in some embodiments) to a lower frequency, such as a cellular band (˜1.9 GHz) for a distributed antenna system, a native frequency, or other frequency for a backhaul system.", "An extractor (or demultiplexer) 1432 can extract the signal on a subcarrier and direct the signal to an output component 1422 for optional amplification, buffering or isolation by power amplifier (“PA”) 1424 for coupling to communications interface 205.The communications interface 205 can further process the signals received from the power amplifier 1424 or otherwise transmit such signals over a wireless or wired interface to other devices such as a base station, mobile devices, a building, etc.", "For the signals that are not being extracted at this location, extractor 1432 can redirect them to another frequency mixer 1436, where the signals are used to modulate a carrier wave generated by local oscillator 1414.The carrier wave, with its subcarriers, is directed to a power amplifier (“PA”) 1416 and is retransmitted by waveguide coupling device 1404 to another system, via diplexer 1420.An LNA 1426 can be used to amplify, buffer or isolate signals that are received by the communication interface 205 and then send the signal to a multiplexer 1434 which merges the signal with signals that have been received from waveguide coupling device 1404.The signals received from coupling device 1404 have been split by diplexer 1420, and then passed through LNA 1418, and downshifted in frequency by frequency mixer 1438.When the signals are combined by multiplexer 1434, they are upshifted in frequency by frequency mixer 1430, and then boosted by PA 1410, and transmitted to another system by waveguide coupling device 1402.In an embodiment bidirectional repeater system can be merely a repeater without the output device 1422.In this embodiment, the multiplexer 1434 would not be utilized and signals from LNA 1418 would be directed to mixer 1430 as previously described.", "It will be appreciated that in some embodiments, the bidirectional repeater system could also be implemented using two distinct and separate unidirectional repeaters.", "In an alternative embodiment, a bidirectional repeater system could also be a booster or otherwise perform retransmissions without downshifting and upshifting.", "Indeed in example embodiment, the retransmissions can be based upon receiving a signal or guided wave and performing some signal or guided wave processing or reshaping, filtering, and/or amplification, prior to retransmission of the signal or guided wave.", "Referring now to FIG.", "15, a block diagram 1500 illustrating an example, non-limiting embodiment of a guided wave communications system is shown.", "This diagram depicts an exemplary environment in which a guided wave communication system, such as the guided wave communication system presented in conjunction with FIG.", "1, can be used.", "To provide network connectivity to additional base station devices, a backhaul network that links the communication cells (e.g., macrocells and macrocells) to network devices of a core network correspondingly expands.", "Similarly, to provide network connectivity to a distributed antenna system, an extended communication system that links base station devices and their distributed antennas is desirable.", "A guided wave communication system 1500 such as shown in FIG.", "15 can be provided to enable alternative, increased or additional network connectivity and a waveguide coupling system can be provided to transmit and/or receive guided wave (e.g., surface wave) communications on a transmission medium such as a wire that operates as a single-wire transmission line (e.g., a utility line), and that can be used as a waveguide and/or that otherwise operates to guide the transmission of an electromagnetic wave.", "The guided wave communication system 1500 can comprise a first instance of a distribution system 1550 that includes one or more base station devices (e.g., base station device 1504) that are communicably coupled to a central office 1501 and/or a macrocell site 1502.Base station device 1504 can be connected by a wired (e.g., fiber and/or cable), or by a wireless (e.g., microwave wireless) connection to the macrocell site 1502 and the central office 1501.A second instance of the distribution system 1560 can be used to provide wireless voice and data services to mobile device 1522 and to residential and/or commercial establishments 1542 (herein referred to as establishments 1542).", "System 1500 can have additional instances of the distribution systems 1550 and 1560 for providing voice and/or data services to mobile devices 1522-1524 and establishments 1542 as shown in FIG.", "15.Macrocells such as macrocell site 1502 can have dedicated connections to a mobile network and base station device 1504 or can share and/or otherwise use another connection.", "Central office 1501 can be used to distribute media content and/or provide internet service provider (ISP) services to mobile devices 1522-1524 and establishments 1542.The central office 1501 can receive media content from a constellation of satellites 1530 (one of which is shown in FIG.", "15) or other sources of content, and distribute such content to mobile devices 1522-1524 and establishments 1542 via the first and second instances of the distribution system 1550 and 1560.The central office 1501 can also be communicatively coupled to the Internet 1503 for providing internet data services to mobile devices 1522-1524 and establishments 1542.Base station device 1504 can be mounted on, or attached to, utility pole 1516.In other embodiments, base station device 1504 can be near transformers and/or other locations situated nearby a power line.", "Base station device 1504 can facilitate connectivity to a mobile network for mobile devices 1522 and 1524.Antennas 1512 and 1514, mounted on or near utility poles 1518 and 1520, respectively, can receive signals from base station device 1504 and transmit those signals to mobile devices 1522 and 1524 over a much wider area than if the antennas 1512 and 1514 were located at or near base station device 1504.It is noted that FIG.", "15 displays three utility poles, in each instance of the distribution systems 1550 and 1560, with one base station device, for purposes of simplicity.", "In other embodiments, utility pole 1516 can have more base station devices, and more utility poles with distributed antennas and/or tethered connections to establishments 1542.A transmission device 1506, such as transmission device 101 or 102 presented in conjunction with FIG.", "1, can transmit a signal from base station device 1504 to antennas 1512 and 1514 via utility or power line(s) that connect the utility poles 1516, 1518, and 1520.To transmit the signal, radio source and/or transmission device 1506 upconverts the signal (e.g., via frequency mixing) from base station device 1504 or otherwise converts the signal from the base station device 1504 to a microwave band signal and the transmission device 1506 launches a microwave band wave that propagates as a guided wave traveling along the utility line or other wire as described in previous embodiments.", "At utility pole 1518, another transmission device 1508 receives the guided wave (and optionally can amplify it as needed or desired or operate as a repeater to receive it and regenerate it) and sends it forward as a guided wave on the utility line or other wire.", "The transmission device 1508 can also extract a signal from the microwave band guided wave and shift it down in frequency or otherwise convert it to its original cellular band frequency (e.g., 1.9 GHz or other defined cellular frequency) or another cellular (or non-cellular) band frequency.", "An antenna 1512 can wireless transmit the downshifted signal to mobile device 1522.The process can be repeated by transmission device 1510, antenna 1514 and mobile device 1524, as necessary or desirable.", "Transmissions from mobile devices 1522 and 1524 can also be received by antennas 1512 and 1514 respectively.", "The transmission devices 1508 and 1510 can upshift or otherwise convert the cellular band signals to microwave band and transmit the signals as guided wave (e.g., surface wave or other electromagnetic wave) transmissions over the power line(s) to base station device 1504.Media content received by the central office 1501 can be supplied to the second instance of the distribution system 1560 via the base station device 1504 for distribution to mobile devices 1522 and establishments 1542.The transmission device 1510 can be tethered to the establishments 1542 by one or more wired connections or a wireless interface.", "The one or more wired connections may include without limitation, a power line, a coaxial cable, a fiber cable, a twisted pair cable, a guided wave transmission medium or other suitable wired mediums for distribution of media content and/or for providing internet services.", "In an example embodiment, the wired connections from the transmission device 1510 can be communicatively coupled to one or more very high bit rate digital subscriber line (VDSL) modems located at one or more corresponding service area interfaces (SAIs—not shown) or pedestals, each SAI or pedestal providing services to a portion of the establishments 1542.The VDSL modems can be used to selectively distribute media content and/or provide internet services to gateways (not shown) located in the establishments 1542.The SAIs or pedestals can also be communicatively coupled to the establishments 1542 over a wired medium such as a power line, a coaxial cable, a fiber cable, a twisted pair cable, a guided wave transmission medium or other suitable wired mediums.", "In other example embodiments, the transmission device 1510 can be communicatively coupled directly to establishments 1542 without intermediate interfaces such as the SAIs or pedestals.", "In another example embodiment, system 1500 can employ diversity paths, where two or more utility lines or other wires are strung between the utility poles 1516, 1518, and 1520 (e.g., for example, two or more wires between poles 1516 and 1520) and redundant transmissions from base station/macrocell site 1502 are transmitted as guided waves down the surface of the utility lines or other wires.", "The utility lines or other wires can be either insulated or uninsulated, and depending on the environmental conditions that cause transmission losses, the coupling devices can selectively receive signals from the insulated or uninsulated utility lines or other wires.", "The selection can be based on measurements of the signal-to-noise ratio of the wires, or based on determined weather/environmental conditions (e.g., moisture detectors, weather forecasts, etc.).", "The use of diversity paths with system 1500 can enable alternate routing capabilities, load balancing, increased load handling, concurrent bi-directional or synchronous communications, spread spectrum communications, etc.", "It is noted that the use of the transmission devices 1506, 1508, and 1510 in FIG.", "15 are by way of example only, and that in other embodiments, other uses are possible.", "For instance, transmission devices can be used in a backhaul communication system, providing network connectivity to base station devices.", "Transmission devices 1506, 1508, and 1510 can be used in many circumstances where it is desirable to transmit guided wave communications over a wire, whether insulated or not insulated.", "Transmission devices 1506, 1508, and 1510 are improvements over other coupling devices due to no contact or limited physical and/or electrical contact with the wires that may carry high voltages.", "The transmission device can be located away from the wire (e.g., spaced apart from the wire) and/or located on the wire so long as it is not electrically in contact with the wire, as the dielectric acts as an insulator, allowing for cheap, easy, and/or less complex installation.", "However, as previously noted conducting or non-dielectric couplers can be employed, for example in configurations where the wires correspond to a telephone network, cable television network, broadband data service, fiber optic communications system or other network employing low voltages or having insulated transmission lines.", "It is further noted, that while base station device 1504 and macrocell site 1502 are illustrated in an embodiment, other network configurations are likewise possible.", "For example, devices such as access points or other wireless gateways can be employed in a similar fashion to extend the reach of other networks such as a wireless local area network, a wireless personal area network or other wireless network that operates in accordance with a communication protocol such as a 802.11 protocol, WIMAX protocol, UltraWideband protocol, BLUETOOTH® protocol, ZIGBEE® protocol or other wireless protocol.", "Referring now to FIGS.", "16A & 16B, block diagrams illustrating an example, non-limiting embodiment of a system for managing a power grid communication system are shown.", "Considering FIG.", "16A, a waveguide system 1602 is presented for use in a guided wave communications system 1600, such as the system presented in conjunction with FIG.", "15.The waveguide system 1602 can comprise sensors 1604, a power management system 1605, a transmission device 101 or 102 that includes at least one communication interface (COMM I/F) 205, transceiver 210 and coupler 220.The waveguide system 1602 can be coupled to a power line 1610 for facilitating guided wave communications in accordance with embodiments described in the subject disclosure.", "In an example embodiment, the transmission device 101 or 102 includes coupler 220 for inducing electromagnetic waves on a surface of the power line 1610 that longitudinally propagate along the surface of the power line 1610 as described in the subject disclosure.", "The transmission device 101 or 102 can also serve as a repeater for retransmitting electromagnetic waves on the same power line 1610 or for routing electromagnetic waves between power lines 1610 as shown in FIGS.", "12-13.The transmission device 101 or 102 includes transceiver 210 configured to, for example, up-convert a signal operating at an original frequency range to electromagnetic waves operating at, exhibiting, or associated with a carrier frequency that propagate along a coupler to induce corresponding guided electromagnetic waves that propagate along a surface of the power line 1610.A carrier frequency can be represented by a center frequency having upper and lower cutoff frequencies that define the bandwidth of the electromagnetic waves.", "The power line 1610 can be a wire (e.g., single stranded or multi-stranded) having a conducting surface or insulated surface.", "The transceiver 210 can also receive signals from the coupler 220 and down-convert the electromagnetic waves operating at a carrier frequency to signals at their original frequency.", "Signals received by the communications interface (COMM I/F) 205 of transmission device 101 or 102 for up-conversion can include without limitation signals supplied by a central office 1611 over a wired or wireless interface of the communications interface 205, a base station 1614 over a wired or wireless interface of the communications interface 205, wireless signals transmitted by mobile devices 1620 to the base station 1614 for delivery over the wired or wireless interface of the communications interface 205, signals supplied by in-building communication devices 1618 over the wired or wireless interface of the communications interface 205, and/or wireless signals supplied to the communications interface 205 by mobile devices 1612 roaming in a wireless communication range of the communications interface 205.In embodiments where the waveguide system 1602 functions as a repeater, such as shown in FIGS.", "12-13, the communications interface 205 may or may not be included in the waveguide system 1602.The electromagnetic waves propagating along the surface of the power line 1610 can be modulated and formatted to include packets or frames of data that include a data payload and further include networking information (such as header information for identifying one or more destination waveguide systems 1602).", "The networking information may be provided by the waveguide system 1602 or an originating device such as the central office 1611, the base station 1614, mobile devices 1620, or in-building devices 1618, or a combination thereof.", "Additionally, the modulated electromagnetic waves can include error correction data for mitigating signal disturbances.", "The networking information and error correction data can be used by a destination waveguide system 1602 for detecting transmissions directed to it, and for down-converting and processing with error correction data transmissions that include voice and/or data signals directed to recipient communication devices communicatively coupled to the destination waveguide system 1602.Referring now to the sensors 1604 of the waveguide system 1602, the sensors 1604 can comprise one or more of a temperature sensor 1604a, a disturbance detection sensor 1604b, a loss of energy sensor 1604c, a noise sensor 1604d, a vibration sensor 1604e, an environmental (e.g., weather) sensor 1604f, and/or an image sensor 1604g.", "The temperature sensor 1604a can be used to measure ambient temperature, a temperature of the transmission device 101 or 102, a temperature of the power line 1610, temperature differentials (e.g., compared to a setpoint or baseline, between transmission device 101 or 102 and 1610, etc.", "), or any combination thereof.", "In one embodiment, temperature metrics can be collected and reported periodically to a network management system 1601 by way of the base station 1614.The disturbance detection sensor 1604b can perform measurements on the power line 1610 to detect disturbances such as signal reflections, which may indicate a presence of a downstream disturbance that may impede the propagation of electromagnetic waves on the power line 1610.A signal reflection can represent a distortion resulting from, for example, an electromagnetic wave transmitted on the power line 1610 by the transmission device 101 or 102 that reflects in whole or in part back to the transmission device 101 or 102 from a disturbance in the power line 1610 located downstream from the transmission device 101 or 102.Signal reflections can be caused by obstructions on the power line 1610.For example, a tree limb may cause electromagnetic wave reflections when the tree limb is lying on the power line 1610, or is in close proximity to the power line 1610 which may cause a corona discharge.", "Other obstructions that can cause electromagnetic wave reflections can include without limitation an object that has been entangled on the power line 1610 (e.g., clothing, a shoe wrapped around a power line 1610 with a shoe string, etc.", "), a corroded build-up on the power line 1610 or an ice build-up.", "Power grid components may also impede or obstruct with the propagation of electromagnetic waves on the surface of power lines 1610.Illustrations of power grid components that may cause signal reflections include without limitation a transformer and a joint for connecting spliced power lines.", "A sharp angle on the power line 1610 may also cause electromagnetic wave reflections.", "The disturbance detection sensor 1604b can comprise a circuit to compare magnitudes of electromagnetic wave reflections to magnitudes of original electromagnetic waves transmitted by the transmission device 101 or 102 to determine how much a downstream disturbance in the power line 1610 attenuates transmissions.", "The disturbance detection sensor 1604b can further comprise a spectral analyzer circuit for performing spectral analysis on the reflected waves.", "The spectral data generated by the spectral analyzer circuit can be compared with spectral profiles via pattern recognition, an expert system, curve fitting, matched filtering or other artificial intelligence, classification or comparison technique to identify a type of disturbance based on, for example, the spectral profile that most closely matches the spectral data.", "The spectral profiles can be stored in a memory of the disturbance detection sensor 1604b or may be remotely accessible by the disturbance detection sensor 1604b.", "The profiles can comprise spectral data that models different disturbances that may be encountered on power lines 1610 to enable the disturbance detection sensor 1604b to identify disturbances locally.", "An identification of the disturbance if known can be reported to the network management system 1601 by way of the base station 1614.The disturbance detection sensor 1604b can also utilize the transmission device 101 or 102 to transmit electromagnetic waves as test signals to determine a roundtrip time for an electromagnetic wave reflection.", "The round trip time measured by the disturbance detection sensor 1604b can be used to calculate a distance traveled by the electromagnetic wave up to a point where the reflection takes place, which enables the disturbance detection sensor 1604b to calculate a distance from the transmission device 101 or 102 to the downstream disturbance on the power line 1610.The distance calculated can be reported to the network management system 1601 by way of the base station 1614.In one embodiment, the location of the waveguide system 1602 on the power line 1610 may be known to the network management system 1601, which the network management system 1601 can use to determine a location of the disturbance on the power line 1610 based on a known topology of the power grid.", "In another embodiment, the waveguide system 1602 can provide its location to the network management system 1601 to assist in the determination of the location of the disturbance on the power line 1610.The location of the waveguide system 1602 can be obtained by the waveguide system 1602 from a pre-programmed location of the waveguide system 1602 stored in a memory of the waveguide system 1602, or the waveguide system 1602 can determine its location using a GPS receiver (not shown) included in the waveguide system 1602.The power management system 1605 provides energy to the aforementioned components of the waveguide system 1602.The power management system 1605 can receive energy from solar cells, or from a transformer (not shown) coupled to the power line 1610, or by inductive coupling to the power line 1610 or another nearby power line.", "The power management system 1605 can also include a backup battery and/or a super capacitor or other capacitor circuit for providing the waveguide system 1602 with temporary power.", "The loss of energy sensor 1604c can be used to detect when the waveguide system 1602 has a loss of power condition and/or the occurrence of some other malfunction.", "For example, the loss of energy sensor 1604c can detect when there is a loss of power due to defective solar cells, an obstruction on the solar cells that causes them to malfunction, loss of power on the power line 1610, and/or when the backup power system malfunctions due to expiration of a backup battery, or a detectable defect in a super capacitor.", "When a malfunction and/or loss of power occurs, the loss of energy sensor 1604c can notify the network management system 1601 by way of the base station 1614.The noise sensor 1604d can be used to measure noise on the power line 1610 that may adversely affect transmission of electromagnetic waves on the power line 1610.The noise sensor 1604d can sense unexpected electromagnetic interference, noise bursts, or other sources of disturbances that may interrupt reception of modulated electromagnetic waves on a surface of a power line 1610.A noise burst can be caused by, for example, a corona discharge, or other source of noise.", "The noise sensor 1604d can compare the measured noise to a noise profile obtained by the waveguide system 1602 from an internal database of noise profiles or from a remotely located database that stores noise profiles via pattern recognition, an expert system, curve fitting, matched filtering or other artificial intelligence, classification or comparison technique.", "From the comparison, the noise sensor 1604d may identify a noise source (e.g., corona discharge or otherwise) based on, for example, the noise profile that provides the closest match to the measured noise.", "The noise sensor 1604d can also detect how noise affects transmissions by measuring transmission metrics such as bit error rate, packet loss rate, jitter, packet retransmission requests, etc.", "The noise sensor 1604d can report to the network management system 1601 by way of the base station 1614 the identity of noise sources, their time of occurrence, and transmission metrics, among other things.", "The vibration sensor 1604e can include accelerometers and/or gyroscopes to detect 2D or 3D vibrations on the power line 1610.The vibrations can be compared to vibration profiles that can be stored locally in the waveguide system 1602, or obtained by the waveguide system 1602 from a remote database via pattern recognition, an expert system, curve fitting, matched filtering or other artificial intelligence, classification or comparison technique.", "Vibration profiles can be used, for example, to distinguish fallen trees from wind gusts based on, for example, the vibration profile that provides the closest match to the measured vibrations.", "The results of this analysis can be reported by the vibration sensor 1604e to the network management system 1601 by way of the base station 1614.The environmental sensor 1604f can include a barometer for measuring atmospheric pressure, ambient temperature (which can be provided by the temperature sensor 1604a), wind speed, humidity, wind direction, and rainfall, among other things.", "The environmental sensor 1604f can collect raw information and process this information by comparing it to environmental profiles that can be obtained from a memory of the waveguide system 1602 or a remote database to predict weather conditions before they arise via pattern recognition, an expert system, knowledge-based system or other artificial intelligence, classification or other weather modeling and prediction technique.", "The environmental sensor 1604f can report raw data as well as its analysis to the network management system 1601.The image sensor 1604g can be a digital camera (e.g., a charged coupled device or CCD imager, infrared camera, etc.)", "for capturing images in a vicinity of the waveguide system 1602.The image sensor 1604g can include an electromechanical mechanism to control movement (e.g., actual position or focal points/zooms) of the camera for inspecting the power line 1610 from multiple perspectives (e.g., top surface, bottom surface, left surface, right surface and so on).", "Alternatively, the image sensor 1604g can be designed such that no electromechanical mechanism is needed in order to obtain the multiple perspectives.", "The collection and retrieval of imaging data generated by the image sensor 1604g can be controlled by the network management system 1601, or can be autonomously collected and reported by the image sensor 1604g to the network management system 1601.Other sensors that may be suitable for collecting telemetry information associated with the waveguide system 1602 and/or the power lines 1610 for purposes of detecting, predicting and/or mitigating disturbances that can impede the propagation of electromagnetic wave transmissions on power lines 1610 (or any other form of a transmission medium of electromagnetic waves) may be utilized by the waveguide system 1602.Referring now to FIG.", "16B, block diagram 1650 illustrates an example, non-limiting embodiment of a system for managing a power grid 1653 and a communication system 1655 embedded therein or associated therewith in accordance with various aspects described herein.", "The communication system 1655 comprises a plurality of waveguide systems 1602 coupled to power lines 1610 of the power grid 1653.At least a portion of the waveguide systems 1602 used in the communication system 1655 can be in direct communication with a base station 1614 and/or the network management system 1601.Waveguide systems 1602 not directly connected to a base station 1614 or the network management system 1601 can engage in communication sessions with either a base station 1614 or the network management system 1601 by way of other downstream waveguide systems 1602 connected to a base station 1614 or the network management system 1601.The network management system 1601 can be communicatively coupled to equipment of a utility company 1652 and equipment of a communications service provider 1654 for providing each entity, status information associated with the power grid 1653 and the communication system 1655, respectively.", "The network management system 1601, the equipment of the utility company 1652, and the communications service provider 1654 can access communication devices utilized by utility company personnel 1656 and/or communication devices utilized by communications service provider personnel 1658 for purposes of providing status information and/or for directing such personnel in the management of the power grid 1653 and/or communication system 1655.FIG.", "17A illustrates a flow diagram of an example, non-limiting embodiment of a method 1700 for detecting and mitigating disturbances occurring in a communication network of the systems of FIGS.", "16A & 16B.", "Method 1700 can begin with step 1702 where a waveguide system 1602 transmits and receives messages embedded in, or forming part of, modulated electromagnetic waves or another type of electromagnetic waves traveling along a surface of a power line 1610.The messages can be voice messages, streaming video, and/or other data/information exchanged between communication devices communicatively coupled to the communication system 1655.At step 1704 the sensors 1604 of the waveguide system 1602 can collect sensing data.", "In an embodiment, the sensing data can be collected in step 1704 prior to, during, or after the transmission and/or receipt of messages in step 1702.At step 1706 the waveguide system 1602 (or the sensors 1604 themselves) can determine from the sensing data an actual or predicted occurrence of a disturbance in the communication system 1655 that can affect communications originating from (e.g., transmitted by) or received by the waveguide system 1602.The waveguide system 1602 (or the sensors 1604) can process temperature data, signal reflection data, loss of energy data, noise data, vibration data, environmental data, or any combination thereof to make this determination.", "The waveguide system 1602 (or the sensors 1604) may also detect, identify, estimate, or predict the source of the disturbance and/or its location in the communication system 1655.If a disturbance is neither detected/identified nor predicted/estimated at step 1708 (i.e., No), the waveguide system 1602 can proceed to step 1702 where it continues to transmit and receive messages embedded in, or forming part of, modulated electromagnetic waves traveling along a surface of the power line 1610.If at step 1708 a disturbance is detected/identified or predicted/estimated to occur (i.e., Yes), the waveguide system 1602 proceeds to step 1710 to determine if the disturbance adversely affects (or alternatively, is likely to adversely affect or the extent to which it may adversely affect) transmission or reception of messages in the communication system 1655.In one embodiment, a duration threshold and a frequency of occurrence threshold can be used at step 1710 to determine when a disturbance adversely affects communications in the communication system 1655.For illustration purposes only, assume a duration threshold is set to 500 ms, while a frequency of occurrence threshold is set to 5 disturbances occurring in an observation period of 10 sec.", "Thus, a disturbance having a duration greater than 500 ms will trigger the duration threshold.", "Additionally, any disturbance occurring more than 5 times in a 10 sec time interval will trigger the frequency of occurrence threshold.", "In one embodiment, a disturbance may be considered to adversely affect signal integrity in the communication systems 1655 when the duration threshold alone is exceeded.", "In another embodiment, a disturbance may be considered as adversely affecting signal integrity in the communication systems 1655 when both the duration threshold and the frequency of occurrence threshold are exceeded.", "The latter embodiment is thus more conservative than the former embodiment for classifying disturbances that adversely affect signal integrity in the communication system 1655.It will be appreciated that many other algorithms and associated parameters and thresholds can be utilized for step 1710 in accordance with example embodiments.", "Referring back to method 1700, if at step 1710 the disturbance detected at step 1708 does not meet the condition (i.e., No) for adversely affected communications (e.g., neither exceeds the duration threshold nor the frequency of occurrence threshold), the waveguide system 1602 may proceed to step 1702 and continue processing messages.", "For instance, if the disturbance detected in step 1708 has a duration of 1 msec with a single occurrence in a 10 sec time period, then neither threshold will be exceeded.", "Consequently, such a disturbance may be considered as having a nominal effect on signal integrity in the communication system 1655 and thus would not be flagged as a disturbance requiring mitigation.", "Although not flagged, the occurrence of the disturbance, its time of occurrence, its frequency of occurrence, spectral data, and/or other useful information, may be reported to the network management system 1601 as telemetry data for monitoring purposes.", "Referring back to step 1710, if on the other hand the disturbance satisfies the condition (i.e., Yes) for adversely affected communications (e.g., exceeds either or both thresholds), the waveguide system 1602 can proceed to step 1712 and report the incident to the network management system 1601.The report can include raw sensing data collected by the sensors 1604, a description of the disturbance if known by the waveguide system 1602, a time of occurrence of the disturbance, a frequency of occurrence of the disturbance, a location associated with the disturbance, parameters readings such as bit error rate, packet loss rate, retransmission requests, jitter, latency and so on.", "If the disturbance is based on a prediction by one or more sensors of the waveguide system 1602, the report can include a type of disturbance expected, and if predictable, an expected time occurrence of the disturbance, and an expected frequency of occurrence of the predicted disturbance when the prediction is based on historical sensing data collected by the sensors 1604 of the waveguide system 1602.At step 1714, the network management system 1601 can determine a mitigation, circumvention, or correction technique, which may include directing the waveguide system 1602 to reroute traffic to circumvent the disturbance if the location of the disturbance can be determined.", "In one embodiment, the waveguide coupling device 1402 detecting the disturbance may direct a repeater such as the one shown in FIGS.", "13-14 to connect the waveguide system 1602 from a primary power line affected by the disturbance to a secondary power line to enable the waveguide system 1602 to reroute traffic to a different transmission medium and avoid the disturbance.", "In an embodiment where the waveguide system 1602 is configured as a repeater the waveguide system 1602 can itself perform the rerouting of traffic from the primary power line to the secondary power line.", "It is further noted that for bidirectional communications (e.g., full or half-duplex communications), the repeater can be configured to reroute traffic from the secondary power line back to the primary power line for processing by the waveguide system 1602.In another embodiment, the waveguide system 1602 can redirect traffic by instructing a first repeater situated upstream of the disturbance and a second repeater situated downstream of the disturbance to redirect traffic from a primary power line temporarily to a secondary power line and back to the primary power line in a manner that avoids the disturbance.", "It is further noted that for bidirectional communications (e.g., full or half-duplex communications), repeaters can be configured to reroute traffic from the secondary power line back to the primary power line.", "To avoid interrupting existing communication sessions occurring on a secondary power line, the network management system 1601 may direct the waveguide system 1602 to instruct repeater(s) to utilize unused time slot(s) and/or frequency band(s) of the secondary power line for redirecting data and/or voice traffic away from the primary power line to circumvent the disturbance.", "At step 1716, while traffic is being rerouted to avoid the disturbance, the network management system 1601 can notify equipment of the utility company 1652 and/or equipment of the communications service provider 1654, which in turn may notify personnel of the utility company 1656 and/or personnel of the communications service provider 1658 of the detected disturbance and its location if known.", "Field personnel from either party can attend to resolving the disturbance at a determined location of the disturbance.", "Once the disturbance is removed or otherwise mitigated by personnel of the utility company and/or personnel of the communications service provider, such personnel can notify their respective companies and/or the network management system 1601 utilizing field equipment (e.g., a laptop computer, smartphone, etc.)", "communicatively coupled to network management system 1601, and/or equipment of the utility company and/or the communications service provider.", "The notification can include a description of how the disturbance was mitigated and any changes to the power lines 1610 that may change a topology of the communication system 1655.At step 1718, the waveguide system 1602 continues to reroute traffic to avoid the disturbances (i.e., No) until the disturbance has been resolved.", "Once the disturbance has been resolved (as determined in decision 1718, i.e., Yes), the network management system 1601 can direct the waveguide system 1602 at step 1720 to restore the previous routing configuration used by the waveguide system 1602 or route traffic according to a new routing configuration if the restoration strategy used to mitigate the disturbance resulted in a new network topology of the communication system 1655.In another embodiment, the waveguide system 1602 can be configured to monitor mitigation of the disturbance by transmitting test signals on the power line 1610 to determine when the disturbance has been removed.", "Once the waveguide system 1602 detects an absence of the disturbance it can autonomously restore its routing configuration without assistance by the network management system 1601 if it determines the network topology of the communication system 1655 has not changed, or it can utilize a new routing configuration that adapts to a detected new network topology.", "FIG.", "17B illustrates a flow diagram of an example, non-limiting embodiment of a method 1750 for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A and 16B.", "In one embodiment, method 1750 can begin with step 1752 where a network management system 1601 receives from equipment of the utility company 1652 or equipment of the communications service provider 1654 maintenance information associated with a maintenance schedule.", "The network management system 1601 can at step 1754 identify from the maintenance information, maintenance activities to be performed during the maintenance schedule.", "From these activities, the network management system 1601 can detect a disturbance resulting from the maintenance (e.g., scheduled replacement of a power line 1610, scheduled replacement of a waveguide system 1602 on the power line 1610, scheduled reconfiguration of power lines 1610 in the power grid 1653, etc.).", "In another embodiment, the network management system 1601 can receive at step 1755 telemetry information from one or more waveguide systems 1602.The telemetry information can include among other things an identity of each waveguide system 1602 submitting the telemetry information, measurements taken by sensors 1604 of each waveguide system 1602, information relating to predicted, estimated, or actual disturbances detected by the sensors 1604 of each waveguide system 1602, location information associated with each waveguide system 1602, an estimated location of a detected disturbance, an identification of the disturbance, and so on.", "The network management system 1601 can determine from the telemetry information a type of disturbance that may be adverse to operations of the waveguide, transmission of the electromagnetic waves along the wire surface, or both.", "The network management system 1601 can also use telemetry information from multiple waveguide systems 1602 to isolate and identify the disturbance.", "Additionally, the network management system 1601 can request telemetry information from waveguide systems 1602 in a vicinity of an affected waveguide system 1602 to triangulate a location of the disturbance and/or validate an identification of the disturbance by receiving similar telemetry information from other waveguide systems 1602.In yet another embodiment, the network management system 1601 can receive at step 1756 an unscheduled activity report from maintenance field personnel.", "Unscheduled maintenance may occur as result of field calls that are unplanned or as a result of unexpected field issues discovered during field calls or scheduled maintenance activities.", "The activity report can identify changes to a topology configuration of the power grid 1653 resulting from field personnel addressing discovered issues in the communication system 1655 and/or power grid 1653, changes to one or more waveguide systems 1602 (such as replacement or repair thereof), mitigation of disturbances performed if any, and so on.", "At step 1758, the network management system 1601 can monitor (i.e., No) and determine from reports received according to steps 1752, 1754, 1755 or 1756 if a disturbance will occur based on a maintenance schedule, or if a disturbance has occurred or is predicted to occur based on telemetry data, or if a disturbance has occurred due to an unplanned maintenance identified in a field activity report.", "From any of these reports, the network management system 1601 can determine whether a detected or predicted disturbance requires rerouting of traffic by the affected waveguide systems 1602 or other waveguide systems 1602 of the communication system 1655.When a disturbance is detected or predicted at step 1758 (i.e., Yes), the network management system 1601 can proceed to step 1760 where it can direct one or more waveguide systems 1602 to reroute traffic to circumvent the disturbance.", "When the disturbance is permanent due to a permanent topology change of the power grid 1653, the network management system 1601 can proceed to step 1770 and skip steps 1762, 1764, 1766, and 1772.At step 1770, the network management system 1601 can direct one or more waveguide systems 1602 to use a new routing configuration that adapts to the new topology.", "However, when the disturbance has been detected from telemetry information supplied by one or more waveguide systems 1602, the network management system 1601 can notify maintenance personnel of the utility company 1656 or the communications service provider 1658 of a location of the disturbance, a type of disturbance if known, and related information that may be helpful to such personnel to mitigate the disturbance.", "When a disturbance is expected due to maintenance activities, the network management system 1601 can direct one or more waveguide systems 1602 to reconfigure traffic routes at a given schedule (consistent with the maintenance schedule) to avoid disturbances caused by the maintenance activities during the maintenance schedule.", "Returning back to step 1760 and upon its completion, the process can continue with step 1762.At step 1762, the network management system 1601 can monitor (i.e., No) when the disturbance(s) have been mitigated by field personnel.", "Mitigation of a disturbance can be detected at step 1762 by analyzing field reports submitted to the network management system 1601 by field personnel over a communications network (e.g., cellular communication system) utilizing field equipment (e.g., a laptop computer or handheld computer/device).", "If field personnel have reported that a disturbance has been mitigated (i.e., Yes), the network management system 1601 can proceed to step 1764 to determine from the field report whether a topology change was required to mitigate the disturbance.", "A topology change can include rerouting a power line 1610, reconfiguring a waveguide system 1602 to utilize a different power line 1610, otherwise utilizing an alternative link to bypass the disturbance and so on.", "If a topology change has taken place (i.e., Yes), the network management system 1601 can direct at step 1770 one or more waveguide systems 1602 to use a new routing configuration that adapts to the new topology.", "If, however, a topology change has not been reported by field personnel (i.e., No) , the network management system 1601 can proceed to step 1766 where it can direct one or more waveguide systems 1602 to send test signals to test a routing configuration that had been used prior to the detected disturbance(s).", "Test signals can be sent to affected waveguide systems 1602 in a vicinity of the disturbance.", "The test signals can be used to determine if signal disturbances (e.g., electromagnetic wave reflections) are detected by any of the waveguide systems 1602.If the test signals confirm that a prior routing configuration is no longer subject to previously detected disturbance(s) (i.e., Pass), then the network management system 1601 can at step 1772 direct the affected waveguide systems 1602 to restore a previous routing configuration.", "If, however, test signals analyzed by one or more waveguide coupling device 1402 and reported to the network management system 1601 indicate that the disturbance(s) or new disturbance(s) are present (i.e., Fail), then the network management system 1601 will proceed to step 1768 and report this information to field personnel to further address field issues.", "The network management system 1601 can in this situation continue to monitor mitigation of the disturbance(s) at step 1762.In the aforementioned embodiments, the waveguide systems 1602 can be configured to be self-adapting to changes in the power grid 1653 and/or to mitigation of disturbances.", "That is, one or more affected waveguide systems 1602 can be configured to self-monitor mitigation of disturbances and reconfigure traffic routes without requiring instructions to be sent to them by the network management system 1601.In this embodiment, the one or more waveguide systems 1602 that are self-configurable can inform the network management system 1601 of its routing choices so that the network management system 1601 can maintain a macro-level view of the communication topology of the communication system 1655.While for purposes of simplicity of explanation, the respective processes are shown and described as a series of blocks in FIGS.", "17A and 17B, respectively, it is to be understood and appreciated that the claimed subject matter is not limited by the order of the blocks, as some blocks may occur in different orders and/or concurrently with other blocks from what is depicted and described herein.", "Moreover, not all illustrated blocks may be required to implement the methods described herein.", "FIGS.", "18A and 18B are block diagrams illustrating example, non-limiting embodiments of guided-wave communications systems in accordance with various aspects described herein.", "FIG.", "18A depicts a waveguide system 1806 coupled to a transmission medium 1801 comprising an insulation layer 1802 and a conductor 1804.A waveguide system 1806 can be placed on the transmission medium 1801 so that the waveguide system 1806 and the transmission medium 1801 are coaxially aligned similar to what is shown by way of reference 1000″′ of FIG.", "10B.", "The waveguide system 1806 can include a waveguide having a cylindrical shape such as shown in FIG.", "10B, or a conical shape as shown in FIG.", "18A.", "Other structure configurations for the waveguide are possible (e.g., rectangular, oval, etc.).", "When the waveguide system 1806 launches guided electromagnetic waves 1808 on an outer surface of an insulated conductor such as the transmission medium 1801 of FIG.", "18A, the guided electromagnetic waves 1806 have a propagation mode that is tightly bound to the insulation layer 1802 and thereby has a radial dimension that can be small (e.g., a few centimeters, depending on the frequency employed).", "Accordingly, the diameter of a waveguide having a conical (or horn) structure as shown in FIG.", "18A can also be small—with a radial dimension of a similar size to the propagation mode of the guided electromagnetic waves 1806.As described herein, in an embodiment, a low leakage launcher for insulated wire requires radius of only a few cm.", "In contrast, guided electromagnetic waves 1810 launched by a waveguide system 1806′ coupled to a transmission medium 1803 using only an uninsulated conductor may result in a propagation mode with a large radial field dimension (e.g., >1 meter) as shown in FIG.", "18B, depending on the frequency of the guided electromagnetic wave 1810.Consequently, the diameter of a waveguide having conical (or horn) structure as shown in FIG.", "18B may be too large for practical purposes.", "As described herein, in an embodiment, a low-leakage launcher for bare wire must have radius >˜1 m. To reduce a size of the waveguide system 1806′ of FIG.", "18B to one much like the waveguide system 1806 of FIG.", "18A, a dielectric (or insulation) material 1802′ similar in dimensions (e.g., thickness) to the insulation material 1802 used by transmission medium 1801 in FIG.", "18A can be applied to conductor 1804 (see, also, FIG.", "18B) of transmission medium 1803 as shown in FIG.", "19.The insulation material 1802′ can be adapted to have a tapered region 1805.As noted earlier, the guided electromagnetic wave 1808 will be tightly coupled to the insulation material 1802′ with a guided wave mode whose electromagnetic field is more closely concentrated around the transmission medium 1801.As a result, a waveguide system 1806 with a commensurately smaller size can be used.", "As the guided electromagnetic wave 1808 propagates longitudinally away from the waveguide system 1806 it will eventually begin to traverse the tapered region 1805 of the insulation material 1802′.", "As the thickness of the insulation layer of the tapered region 1805 decreases near the beginning of the tapered region 1805, a radial dimension of the guided electromagnetic wave 1808′ increases as a result of the electromagnetic wave 1808′ being less tightly bound to the insulation layer 1802.Mid-way through the tapered region 1805, the radial dimension of the guided electromagnetic wave 1808″ continues to expand as the thickness of the insulation layer 1802′ continues to decrease.", "At or near a transition point after the tapered region 1805 ends, i.e., where there is no insulation (i.e., a bare conductor), the guided electromagnetic wave 1810 can have a radial dimension as previously discussed in relation to FIG.", "18B (e.g., 1 meter, depending on the frequency of the electromagnetic wave 1808).", "By applying an insulation material 1802′ with a tapered region 1805 to a bare conductor, the radial dimension of a waveguide system 1806 can be designed to be similar in size, slightly larger for example, than the radial dimension of the guided electromagnetic wave 1808—rather than being sized to the guided electromagnetic wave 1810.In this fashion, the size of the waveguide system 1806 can be kept much smaller while maintaining efficient transmission (e.g., one or more orders of magnitude smaller, such as a few centimeters, as opposed to 1 meter or more, depending on the frequency).", "As described herein, in an embodiment, to make small, low-leakage launcher for bare wire, add tapered section of insulation ˜1-m long.", "Mode will expand as it travels along the taper.", "It is further noted that the configurations depicted in FIG.", "19 enable bidirectional propagation of guided electromagnetic waves with the benefits previously described.", "That is, as guided electromagnetic waves 1810 propagate towards the waveguide system 1806, a radial dimension of such waves begins to decrease as the waves traverse the tapered region 1805 depicted by the sequence of guided electromagnetic waves 1808″, 1808′ and 1808.This property enables bidirectional communications between waveguide systems 1806 that modulate the guided electromagnetic waves with communication signals that include voice, streaming content, other data and so on.", "It is further noted that the embodiments shown in FIG.", "19 can also be applied in situations where a transmission medium has an insulated conductor, but the thickness of the insulation is very thin resulting in large radial electromagnetic fields.", "It is further noted that a waveguide system 1806 of FIG.", "19 can be mirror imaged (not shown) so that the waveguide system 1806 comprises two waveguides pointing in opposite directions (e.g., one pointing in one direction along the transmission medium 1803 and the other pointing in the opposite direction).", "In this configuration, the insulation layer 1802 can have two tapered ends, one facing in one direction and the other facing in the opposite direction, but a distance apart.", "By having two waveguides, the waveguide system 1806 can be adapted to receive and transmit guided electromagnetic waves in both directions along the transmission medium exhibiting the radial properties previously discussed.", "In some embodiments, the waveguide system 1806 can be adapted to act as repeater or enable a bypass mode for certain guided electromagnetic waves.", "Accordingly, electromagnetic waves propagating from west to east can be repeated (e.g., received and regenerated or merely amplified) or allowed to bypass the waveguide system 1806 in one direction.", "Similarly, electromagnetic waves propagating in the other direction can be repeated (e.g., received/amplified) or allowed to bypass the waveguide system 1806 in the other direction.", "In another embodiment, the waveguide systems described above could be used at a junction of several transmission media to transmit, receive and/or repeat waves in more than just two directions.", "In another embodiment, conductor 1804 can be an insulated conductor.", "The insulation layer 1802′ with tapered region 1805 can be preinstalled on transmission medium 1803 or can placed manually or with a mechanical device.", "For example, the insulation layer 1802′ with tapered region 1805 can be constructed as a component of the waveguide system 1806 having a bottom slit enabling placement on a bare conductor or thinly insulated conductor or otherwise can be attached or molded in place.", "Alternatively, the insulation layer 1802′ with tapered region 1805 can be an independent part that is not an integral to the waveguide 1806.In this embodiment, the insulation layer 1802′ with tapered region 1805 can be placed on a bare conductor or thinly insulated conductor first, followed by a placement of the waveguide system 1806 on the insulation layer 1802′.", "It is further noted that the insulation layer 1802 and tapered region 1805 does not have to fully cover a circumference of a bare or thinly insulated conductor.", "Turning now to FIG.", "20A, a flow diagram of an example, non-limiting embodiment of a method 2000, is shown.", "In particular, a method 2000 is presented for use with one or more functions and features presented in conjunction with FIGS.", "1-4, 5A-5B, 6-8, 9A-9B, 10A-10B, 11-15, 16A-16B, 17A-17B, 18A-18B and 19.At step 2002 a waveguide system receives a first communication signal and according to the embodiments of the subject disclosure, at step 2004, induces first electromagnetic waves that propagate longitudinally on a transmission medium such as described in the subject disclosure.", "Turning now to FIG.", "20B, a flow diagram of an example, non-limiting embodiment of a method 2020, is shown.", "In particular, a method 2020 is presented for use with one or more functions and features presented in conjunction with FIGS.", "1-4, 5A-5B, 6-8, 9A-9B, 10A-10B, 11-15, 16A-16B, 17A-17B, 18A-18B and 19.At step 2022 a waveguide system receives second electromagnetic waves propagating on a transmission medium and according to the embodiments of the subject disclosure, at step 2024 converts the second electromagnetic waves to a second communication signal.", "The methods 2000 and 2020 provide for a bidirectional communication system.", "Referring now to FIG.", "21, there is illustrated a block diagram of a computing environment in accordance with various aspects described herein.", "In order to provide additional context for various embodiments of the embodiments described herein, FIG.", "21 and the following discussion are intended to provide a brief, general description of a suitable computing environment 2100 in which the various embodiments of the subject disclosure can be implemented.", "While the embodiments have been described above in the general context of computer-executable instructions that can run on one or more computers, those skilled in the art will recognize that the embodiments can be also implemented in combination with other program modules and/or as a combination of hardware and software.", "Generally, program modules comprise routines, programs, components, data structures, etc., that perform particular tasks or implement particular abstract data types.", "Moreover, those skilled in the art will appreciate that the inventive methods can be practiced with other computer system configurations, comprising single-processor or multiprocessor computer systems, minicomputers, mainframe computers, as well as personal computers, hand-held computing devices, microprocessor-based or programmable consumer electronics, and the like, each of which can be operatively coupled to one or more associated devices.", "As used herein, a processing circuit includes processor as well as other application specific circuits such as an application specific integrated circuit, digital logic circuit, state machine, programmable gate array or other circuit that processes input signals or data and that produces output signals or data in response thereto.", "It should be noted that while any functions and features described herein in association with the operation of a processor could likewise be performed by a processing circuit.", "The terms “first,” “second,” “third,” and so forth, as used in the claims, unless otherwise clear by context, is for clarity only and doesn't otherwise indicate or imply any order in time.", "For instance, “a first determination,” “a second determination,” and “a third determination,” does not indicate or imply that the first determination is to be made before the second determination, or vice versa, etc.", "The illustrated embodiments of the embodiments herein can be also practiced in distributed computing environments where certain tasks are performed by remote processing devices that are linked through a communications network.", "In a distributed computing environment, program modules can be located in both local and remote memory storage devices.", "Computing devices typically comprise a variety of media, which can comprise computer-readable storage media and/or communications media, which two terms are used herein differently from one another as follows.", "Computer-readable storage media can be any available storage media that can be accessed by the computer and comprises both volatile and nonvolatile media, removable and non-removable media.", "By way of example, and not limitation, computer-readable storage media can be implemented in connection with any method or technology for storage of information such as computer-readable instructions, program modules, structured data or unstructured data.", "Computer-readable storage media can comprise, but are not limited to, random access memory (RAM), read only memory (ROM), electrically erasable programmable read only memory (EEPROM), flash memory or other memory technology, compact disk read only memory (CD-ROM), digital versatile disk (DVD) or other optical disk storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices or other tangible and/or non-transitory media which can be used to store desired information.", "In this regard, the terms “tangible” or “non-transitory” herein as applied to storage, memory or computer-readable media, are to be understood to exclude only propagating transitory signals per se as modifiers and do not relinquish rights to all standard storage, memory or computer-readable media that are not only propagating transitory signals per se.", "Computer-readable storage media can be accessed by one or more local or remote computing devices, e.g., via access requests, queries or other data retrieval protocols, for a variety of operations with respect to the information stored by the medium.", "Communications media typically embody computer-readable instructions, data structures, program modules or other structured or unstructured data in a data signal such as a modulated data signal, e.g., a carrier wave or other transport mechanism, and comprises any information delivery or transport media.", "The term “modulated data signal” or signals refers to a signal that has one or more of its characteristics set or changed in such a manner as to encode information in one or more signals.", "By way of example, and not limitation, communication media comprise wired media, such as a wired network or direct-wired connection, and wireless media such as acoustic, RF, infrared and other wireless media.", "With reference again to FIG.", "21, the example environment 2100 for transmitting and receiving signals via or forming at least part of a base station (e.g., base station devices 1504, macrocell site 1502, or base stations 1614) or central office (e.g., central office 1501 or 1611).", "At least a portion of the example environment 2100 can also be used for transmission devices 101 or 102.The example environment can comprise a computer 2102, the computer 2102 comprising a processing unit 2104, a system memory 2106 and a system bus 2108.The system bus 2108 couples system components including, but not limited to, the system memory 2106 to the processing unit 2104.The processing unit 2104 can be any of various commercially available processors.", "Dual microprocessors and other multiprocessor architectures can also be employed as the processing unit 2104.The system bus 2108 can be any of several types of bus structure that can further interconnect to a memory bus (with or without a memory controller), a peripheral bus, and a local bus using any of a variety of commercially available bus architectures.", "The system memory 2106 comprises ROM 2110 and RAM 2112.A basic input/output system (BIOS) can be stored in a non-volatile memory such as ROM, erasable programmable read only memory (EPROM), EEPROM, which BIOS contains the basic routines that help to transfer information between elements within the computer 2102, such as during startup.", "The RAM 2112 can also comprise a high-speed RAM such as static RAM for caching data.", "The computer 2102 further comprises an internal hard disk drive (HDD) 2114 (e.g., EIDE, SATA), which internal hard disk drive 2114 can also be configured for external use in a suitable chassis (not shown), a magnetic floppy disk drive (FDD) 2116, (e.g., to read from or write to a removable diskette 2118) and an optical disk drive 2120, (e.g., reading a CD-ROM disk 2122 or, to read from or write to other high capacity optical media such as the DVD).", "The hard disk drive 2114, magnetic disk drive 2116 and optical disk drive 2120 can be connected to the system bus 2108 by a hard disk drive interface 2124, a magnetic disk drive interface 2126 and an optical drive interface 2128, respectively.", "The interface 2124 for external drive implementations comprises at least one or both of Universal Serial Bus (USB) and Institute of Electrical and Electronics Engineers (IEEE) 1394 interface technologies.", "Other external drive connection technologies are within contemplation of the embodiments described herein.", "The drives and their associated computer-readable storage media provide nonvolatile storage of data, data structures, computer-executable instructions, and so forth.", "For the computer 2102, the drives and storage media accommodate the storage of any data in a suitable digital format.", "Although the description of computer-readable storage media above refers to a hard disk drive (HDD), a removable magnetic diskette, and a removable optical media such as a CD or DVD, it should be appreciated by those skilled in the art that other types of storage media which are readable by a computer, such as zip drives, magnetic cassettes, flash memory cards, cartridges, and the like, can also be used in the example operating environment, and further, that any such storage media can contain computer-executable instructions for performing the methods described herein.", "A number of program modules can be stored in the drives and RAM 2112, comprising an operating system 2130, one or more application programs 2132, other program modules 2134 and program data 2136.All or portions of the operating system, applications, modules, and/or data can also be cached in the RAM 2112.The systems and methods described herein can be implemented utilizing various commercially available operating systems or combinations of operating systems.", "Examples of application programs 2132 that can be implemented and otherwise executed by processing unit 2104 include the diversity selection determining performed by transmission device 101 or 102.A user can enter commands and information into the computer 2102 through one or more wired/wireless input devices, e.g., a keyboard 2138 and a pointing device, such as a mouse 2140.Other input devices (not shown) can comprise a microphone, an infrared (IR) remote control, a joystick, a game pad, a stylus pen, touch screen or the like.", "These and other input devices are often connected to the processing unit 2104 through an input device interface 2142 that can be coupled to the system bus 2108, but can be connected by other interfaces, such as a parallel port, an IEEE 1394 serial port, a game port, a universal serial bus (USB) port, an IR interface, etc.", "A monitor 2144 or other type of display device can be also connected to the system bus 2108 via an interface, such as a video adapter 2146.It will also be appreciated that in alternative embodiments, a monitor 2144 can also be any display device (e.g., another computer having a display, a smart phone, a tablet computer, etc.)", "for receiving display information associated with computer 2102 via any communication means, including via the Internet and cloud-based networks.", "In addition to the monitor 2144, a computer typically comprises other peripheral output devices (not shown), such as speakers, printers, etc.", "The computer 2102 can operate in a networked environment using logical connections via wired and/or wireless communications to one or more remote computers, such as a remote computer(s) 2148.The remote computer(s) 2148 can be a workstation, a server computer, a router, a personal computer, portable computer, microprocessor-based entertainment appliance, a peer device or other common network node, and typically comprises many or all of the elements described relative to the computer 2102, although, for purposes of brevity, only a memory/storage device 2150 is illustrated.", "The logical connections depicted comprise wired/wireless connectivity to a local area network (LAN) 2152 and/or larger networks, e.g., a wide area network (WAN) 2154.Such LAN and WAN networking environments are commonplace in offices and companies, and facilitate enterprise-wide computer networks, such as intranets, all of which can connect to a global communications network, e.g., the Internet.", "When used in a LAN networking environment, the computer 2102 can be connected to the local network 2152 through a wired and/or wireless communication network interface or adapter 2156.The adapter 2156 can facilitate wired or wireless communication to the LAN 2152, which can also comprise a wireless AP disposed thereon for communicating with the wireless adapter 2156.When used in a WAN networking environment, the computer 2102 can comprise a modem 2158 or can be connected to a communications server on the WAN 2154 or has other means for establishing communications over the WAN 2154, such as by way of the Internet.", "The modem 2158, which can be internal or external and a wired or wireless device, can be connected to the system bus 2108 via the input device interface 2142.In a networked environment, program modules depicted relative to the computer 2102 or portions thereof, can be stored in the remote memory/storage device 2150.It will be appreciated that the network connections shown are example and other means of establishing a communications link between the computers can be used.", "The computer 2102 can be operable to communicate with any wireless devices or entities operatively disposed in wireless communication, e.g., a printer, scanner, desktop and/or portable computer, portable data assistant, communications satellite, any piece of equipment or location associated with a wirelessly detectable tag (e.g., a kiosk, news stand, restroom), and telephone.", "This can comprise Wireless Fidelity (Wi-Fi) and BLUETOOTH® wireless technologies.", "Thus, the communication can be a predefined structure as with a conventional network or simply an ad hoc communication between at least two devices.", "Wi-Fi can allow connection to the Internet from a couch at home, a bed in a hotel room or a conference room at work, without wires.", "Wi-Fi is a wireless technology similar to that used in a cell phone that enables such devices, e.g., computers, to send and receive data indoors and out; anywhere within the range of a base station.", "Wi-Fi networks use radio technologies called IEEE 802.11 (a, b, g, n, ac, ag, etc.)", "to provide secure, reliable, fast wireless connectivity.", "A Wi-Fi network can be used to connect computers to each other, to the Internet, and to wired networks (which can use IEEE 802.3 or Ethernet).", "Wi-Fi networks operate in the unlicensed 2.4 and 5 GHz radio bands for example or with products that contain both bands (dual band), so the networks can provide real-world performance similar to the basic 10BaseT wired Ethernet networks used in many offices.", "FIG.", "22 presents an example embodiment 2200 of a mobile network platform 2210 that can implement and exploit one or more aspects of the disclosed subject matter described herein.", "In one or more embodiments, the mobile network platform 2210 can generate and receive signals transmitted and received by base stations (e.g., base station devices 1504, macrocell site 1502, or base stations 1614), central office (e.g., central office 1501 or 1611),or transmission device 101 or 102 associated with the disclosed subject matter.", "Generally, wireless network platform 2210 can comprise components, e.g., nodes, gateways, interfaces, servers, or disparate platforms, that facilitate both packet-switched (PS) (e.g., internet protocol (IP), frame relay, asynchronous transfer mode (ATM)) and circuit-switched (CS) traffic (e.g., voice and data), as well as control generation for networked wireless telecommunication over a radio access network (RAN).", "As a non-limiting example, wireless network platform 2210 can be included in telecommunications carrier networks, and can be considered carrier-side components as discussed elsewhere herein.", "Mobile network platform 2210 comprises CS gateway node(s) 2222 which can interface CS traffic received from legacy networks like telephony network(s) 2240 (e.g., public switched telephone network (PSTN), or public land mobile network (PLMN)) or a signaling system #7 (SS7) network 2260.Circuit switched gateway node(s) 2222 can authorize and authenticate traffic (e.g., voice) arising from such networks.", "Additionally, CS gateway node(s) 2222 can access mobility, or roaming, data generated through SS7 network 2260; for instance, mobility data stored in a visited location register (VLR), which can reside in memory 2230.Moreover, CS gateway node(s) 2222 interfaces CS-based traffic and signaling and PS gateway node(s) 2218.As an example, in a 3GPP UMTS network, CS gateway node(s) 2222 can be realized at least in part in gateway GPRS support node(s) (GGSN).", "It should be appreciated that functionality and specific operation of CS gateway node(s) 2222, PS gateway node(s) 2218, and serving node(s) 2216, is provided and dictated by radio technology(ies) utilized by mobile network platform 2210 for telecommunication.", "In addition to receiving and processing CS-switched traffic and signaling, PS gateway node(s) 2218 can authorize and authenticate PS-based data sessions with served mobile devices.", "Data sessions can comprise traffic, or content(s), exchanged with networks external to the wireless network platform 2210, like wide area network(s) (WANs) 2250, enterprise network(s) 2270, and service network(s) 2280, which can be embodied in local area network(s) (LANs), can also be interfaced with mobile network platform 2210 through PS gateway node(s) 2218.It is to be noted that WANs 2250 and enterprise network(s) 2270 can embody, at least in part, a service network(s) like IP multimedia subsystem (IMS).", "Based on radio technology layer(s) available in technology resource(s), packet-switched gateway node(s) 2218 can generate packet data protocol contexts when a data session is established; other data structures that facilitate routing of packetized data also can be generated.", "To that end, in an aspect, PS gateway node(s) 2218 can comprise a tunnel interface (e.g., tunnel termination gateway (TTG) in 3GPP UMTS network(s) (not shown)) which can facilitate packetized communication with disparate wireless network(s), such as Wi-Fi networks.", "In embodiment 2200, wireless network platform 2210 also comprises serving node(s) 2216 that, based upon available radio technology layer(s) within technology resource(s), convey the various packetized flows of data streams received through PS gateway node(s) 2218.It is to be noted that for technology resource(s) that rely primarily on CS communication, server node(s) can deliver traffic without reliance on PS gateway node(s) 2218; for example, server node(s) can embody at least in part a mobile switching center.", "As an example, in a 3GPP UMTS network, serving node(s) 2216 can be embodied in serving GPRS support node(s) (SGSN).", "For radio technologies that exploit packetized communication, server(s) 2214 in wireless network platform 2210 can execute numerous applications that can generate multiple disparate packetized data streams or flows, and manage (e.g., schedule, queue, format .", ".", ". )", "such flows.", "Such application(s) can comprise add-on features to standard services (for example, provisioning, billing, customer support .", ".", ". )", "provided by wireless network platform 2210.Data streams (e.g., content(s) that are part of a voice call or data session) can be conveyed to PS gateway node(s) 2218 for authorization/authentication and initiation of a data session, and to serving node(s) 2216 for communication thereafter.", "In addition to application server, server(s) 2214 can comprise utility server(s), a utility server can comprise a provisioning server, an operations and maintenance server, a security server that can implement at least in part a certificate authority and firewalls as well as other security mechanisms, and the like.", "In an aspect, security server(s) secure communication served through wireless network platform 2210 to ensure network's operation and data integrity in addition to authorization and authentication procedures that CS gateway node(s) 2222 and PS gateway node(s) 2218 can enact.", "Moreover, provisioning server(s) can provision services from external network(s) like networks operated by a disparate service provider; for instance, WAN 2250 or Global Positioning System (GPS) network(s) (not shown).", "Provisioning server(s) can also provision coverage through networks associated to wireless network platform 2210 (e.g., deployed and operated by the same service provider), such as the distributed antennas networks shown in FIG.", "1(s) that enhance wireless service coverage by providing more network coverage.", "Repeater devices such as those shown in FIGS.", "7, 8, and 9 also improve network coverage in order to enhance subscriber service experience by way of user equipment (UE) 2275.It is to be noted that server(s) 2214 can comprise one or more processors configured to confer at least in part the functionality of macro network platform 2210.To that end, the one or more processor can execute code instructions stored in memory 2230, for example.", "It is should be appreciated that server(s) 2214 can comprise a content manager, which operates in substantially the same manner as described hereinbefore.", "In example embodiment 2200, memory 2230 can store information related to operation of wireless network platform 2210.Other operational information can comprise provisioning information of mobile devices served through wireless platform network 2210, subscriber databases; application intelligence, pricing schemes, e.g., promotional rates, flat-rate programs, couponing campaigns; technical specification(s) consistent with telecommunication protocols for operation of disparate radio, or wireless, technology layers; and so forth.", "Memory 2230 can also store information from at least one of telephony network(s) 2240, WAN 2250, enterprise network(s) 2270, or SS7 network 2260.In an aspect, memory 2230 can be, for example, accessed as part of a data store component or as a remotely connected memory store.", "In order to provide a context for the various aspects of the disclosed subject matter, FIG.", "22, and the following discussion, are intended to provide a brief, general description of a suitable environment in which the various aspects of the disclosed subject matter can be implemented.", "While the subject matter has been described above in the general context of computer-executable instructions of a computer program that runs on a computer and/or computers, those skilled in the art will recognize that the disclosed subject matter also can be implemented in combination with other program modules.", "Generally, program modules comprise routines, programs, components, data structures, etc.", "that perform particular tasks and/or implement particular abstract data types.", "FIG.", "23 depicts an illustrative embodiment of a communication device 2300.The communication device 2300 can serve as an illustrative embodiment of devices such as mobile devices and in-building devices referred to by the subject disclosure (e.g., in FIGS.", "15, 16A and 16B).", "The communication device 2300 can comprise a wireline and/or wireless transceiver 2302 (herein transceiver 2302), a user interface (UI) 2304, a power supply 2314, a location receiver 2316, a motion sensor 2318, an orientation sensor 2320, and a controller 2306 for managing operations thereof.", "The transceiver 2302 can support short-range or long-range wireless access technologies such as BLUETOOTH®, ZIGBEE®, WiFi, DECT, or cellular communication technologies, just to mention a few (BLUETOOTH® and ZIGBEE® are trademarks registered by the BLUETOOTH® Special Interest Group and the ZIGBEE® Alliance, respectively).", "Cellular technologies can include, for example, CDMA-1X, UMTS/HSDPA, GSM/GPRS, TDMA/EDGE, EV/DO, WiMAX, SDR, LTE, as well as other next generation wireless communication technologies as they arise.", "The transceiver 2302 can also be adapted to support circuit-switched wireline access technologies (such as PSTN), packet-switched wireline access technologies (such as TCP/IP, VoIP, etc.", "), and combinations thereof.", "The UI 2304 can include a depressible or touch-sensitive keypad 2308 with a navigation mechanism such as a roller ball, a joystick, a mouse, or a navigation disk for manipulating operations of the communication device 2300.The keypad 2308 can be an integral part of a housing assembly of the communication device 2300 or an independent device operably coupled thereto by a tethered wireline interface (such as a USB cable) or a wireless interface supporting for example Bluetooth®.", "The keypad 2308 can represent a numeric keypad commonly used by phones, and/or a QWERTY keypad with alphanumeric keys.", "The UI 2304 can further include a display 2310 such as monochrome or color LCD (Liquid Crystal Display), OLED (Organic Light Emitting Diode) or other suitable display technology for conveying images to an end user of the communication device 2300.In an embodiment where the display 2310 is touch-sensitive, a portion or all of the keypad 2308 can be presented by way of the display 2310 with navigation features.", "The display 2310 can use touch screen technology to also serve as a user interface for detecting user input.", "As a touch screen display, the communication device 2300 can be adapted to present a user interface having graphical user interface (GUI) elements that can be selected by a user with a touch of a finger.", "The touch screen display 2310 can be equipped with capacitive, resistive or other forms of sensing technology to detect how much surface area of a user's finger has been placed on a portion of the touch screen display.", "This sensing information can be used to control the manipulation of the GUI elements or other functions of the user interface.", "The display 2310 can be an integral part of the housing assembly of the communication device 2300 or an independent device communicatively coupled thereto by a tethered wireline interface (such as a cable) or a wireless interface.", "The UI 2304 can also include an audio system 2312 that utilizes audio technology for conveying low volume audio (such as audio heard in proximity of a human ear) and high volume audio (such as speakerphone for hands free operation).", "The audio system 2312 can further include a microphone for receiving audible signals of an end user.", "The audio system 2312 can also be used for voice recognition applications.", "The UI 2304 can further include an image sensor 2313 such as a charged coupled device (CCD) camera for capturing still or moving images.", "The power supply 2314 can utilize common power management technologies such as replaceable and rechargeable batteries, supply regulation technologies, and/or charging system technologies for supplying energy to the components of the communication device 2300 to facilitate long-range or short-range portable communications.", "Alternatively, or in combination, the charging system can utilize external power sources such as DC power supplied over a physical interface such as a USB port or other suitable tethering technologies.", "The location receiver 2316 can utilize location technology such as a global positioning system (GPS) receiver capable of assisted GPS for identifying a location of the communication device 2300 based on signals generated by a constellation of GPS satellites, which can be used for facilitating location services such as navigation.", "The motion sensor 2318 can utilize motion sensing technology such as an accelerometer, a gyroscope, or other suitable motion sensing technology to detect motion of the communication device 2300 in three-dimensional space.", "The orientation sensor 2320 can utilize orientation sensing technology such as a magnetometer to detect the orientation of the communication device 2300 (north, south, west, and east, as well as combined orientations in degrees, minutes, or other suitable orientation metrics).", "The communication device 2300 can use the transceiver 2302 to also determine a proximity to a cellular, WiFi, Bluetooth®, or other wireless access points by sensing techniques such as utilizing a received signal strength indicator (RSSI) and/or signal time of arrival (TOA) or time of flight (TOF) measurements.", "The controller 2306 can utilize computing technologies such as a microprocessor, a digital signal processor (DSP), programmable gate arrays, application specific integrated circuits, and/or a video processor with associated storage memory such as Flash, ROM, RAM, SRAM, DRAM or other storage technologies for executing computer instructions, controlling, and processing data supplied by the aforementioned components of the communication device 2300.Other components not shown in FIG.", "23 can be used in one or more embodiments of the subject disclosure.", "For instance, the communication device 2300 can include a slot for adding or removing an identity module such as a Subscriber Identity Module (SIM) card or Universal Integrated Circuit Card (UICC).", "SIM or UICC cards can be used for identifying subscriber services, executing programs, storing subscriber data, and so on.", "In the subject specification, terms such as “store,” “storage,” “data store,” data storage,” “database,” and substantially any other information storage component relevant to operation and functionality of a component, refer to “memory components,” or entities embodied in a “memory” or components comprising the memory.", "It will be appreciated that the memory components described herein can be either volatile memory or nonvolatile memory, or can comprise both volatile and nonvolatile memory, by way of illustration, and not limitation, volatile memory, non-volatile memory, disk storage, and memory storage.", "Further, nonvolatile memory can be included in read only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable ROM (EEPROM), or flash memory.", "Volatile memory can comprise random access memory (RAM), which acts as external cache memory.", "By way of illustration and not limitation, RAM is available in many forms such as synchronous RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDR SDRAM), enhanced SDRAM (ESDRAM), Synchlink DRAM (SLDRAM), and direct Rambus RAM (DRRAM).", "Additionally, the disclosed memory components of systems or methods herein are intended to comprise, without being limited to comprising, these and any other suitable types of memory.", "Moreover, it will be noted that the disclosed subject matter can be practiced with other computer system configurations, comprising single-processor or multiprocessor computer systems, mini-computing devices, mainframe computers, as well as personal computers, hand-held computing devices (e.g., PDA, phone, smartphone, watch, tablet computers, netbook computers, etc.", "), microprocessor-based or programmable consumer or industrial electronics, and the like.", "The illustrated aspects can also be practiced in distributed computing environments where tasks are performed by remote processing devices that are linked through a communications network; however, some if not all aspects of the subject disclosure can be practiced on stand-alone computers.", "In a distributed computing environment, program modules can be located in both local and remote memory storage devices.", "Some of the embodiments described herein can also employ artificial intelligence (AI) to facilitate automating one or more features described herein.", "For example, artificial intelligence can be used in optional training controller 230 evaluate and select candidate frequencies, modulation schemes, MIMO modes, and/or guided wave modes in order to maximize transfer efficiency.", "The embodiments (e.g., in connection with automatically identifying acquired cell sites that provide a maximum value/benefit after addition to an existing communication network) can employ various AI-based schemes for carrying out various embodiments thereof.", "Moreover, the classifier can be employed to determine a ranking or priority of the each cell site of the acquired network.", "A classifier is a function that maps an input attribute vector, x=(x1, x2, x3, x4, .", ".", ".", ", xn), to a confidence that the input belongs to a class, that is, f(x)=confidence (class).", "Such classification can employ a probabilistic and/or statistical-based analysis (e.g., factoring into the analysis utilities and costs) to prognose or infer an action that a user desires to be automatically performed.", "A support vector machine (SVM) is an example of a classifier that can be employed.", "The SVM operates by finding a hypersurface in the space of possible inputs, which the hypersurface attempts to split the triggering criteria from the non-triggering events.", "Intuitively, this makes the classification correct for testing data that is near, but not identical to training data.", "Other directed and undirected model classification approaches comprise, e.g., naïve Bayes, Bayesian networks, decision trees, neural networks, fuzzy logic models, and probabilistic classification models providing different patterns of independence can be employed.", "Classification as used herein also is inclusive of statistical regression that is utilized to develop models of priority.", "As will be readily appreciated, one or more of the embodiments can employ classifiers that are explicitly trained (e.g., via a generic training data) as well as implicitly trained (e.g., via observing UE behavior, operator preferences, historical information, receiving extrinsic information).", "For example, SVMs can be configured via a learning or training phase within a classifier constructor and feature selection module.", "Thus, the classifier(s) can be used to automatically learn and perform a number of functions, including but not limited to determining according to a predetermined criteria which of the acquired cell sites will benefit a maximum number of subscribers and/or which of the acquired cell sites will add minimum value to the existing communication network coverage, etc.", "As used in some contexts in this application, in some embodiments, the terms “component,” “system” and the like are intended to refer to, or comprise, a computer-related entity or an entity related to an operational apparatus with one or more specific functionalities, wherein the entity can be either hardware, a combination of hardware and software, software, or software in execution.", "As an example, a component may be, but is not limited to being, a process running on a processor, a processor, an object, an executable, a thread of execution, computer-executable instructions, a program, and/or a computer.", "By way of illustration and not limitation, both an application running on a server and the server can be a component.", "One or more components may reside within a process and/or thread of execution and a component may be localized on one computer and/or distributed between two or more computers.", "In addition, these components can execute from various computer readable media having various data structures stored thereon.", "The components may communicate via local and/or remote processes such as in accordance with a signal having one or more data packets (e.g., data from one component interacting with another component in a local system, distributed system, and/or across a network such as the Internet with other systems via the signal).", "As another example, a component can be an apparatus with specific functionality provided by mechanical parts operated by electric or electronic circuitry, which is operated by a software or firmware application executed by a processor, wherein the processor can be internal or external to the apparatus and executes at least a part of the software or firmware application.", "As yet another example, a component can be an apparatus that provides specific functionality through electronic components without mechanical parts, the electronic components can comprise a processor therein to execute software or firmware that confers at least in part the functionality of the electronic components.", "While various components have been illustrated as separate components, it will be appreciated that multiple components can be implemented as a single component, or a single component can be implemented as multiple components, without departing from example embodiments.", "Further, the various embodiments can be implemented as a method, apparatus or article of manufacture using standard programming and/or engineering techniques to produce software, firmware, hardware or any combination thereof to control a computer to implement the disclosed subject matter.", "The term “article of manufacture” as used herein is intended to encompass a computer program accessible from any computer-readable device or computer-readable storage/communications media.", "For example, computer readable storage media can include, but are not limited to, magnetic storage devices (e.g., hard disk, floppy disk, magnetic strips), optical disks (e.g., compact disk (CD), digital versatile disk (DVD)), smart cards, and flash memory devices (e.g., card, stick, key drive).", "Of course, those skilled in the art will recognize many modifications can be made to this configuration without departing from the scope or spirit of the various embodiments.", "In addition, the words “example” and “exemplary” are used herein to mean serving as an instance or illustration.", "Any embodiment or design described herein as “example” or “exemplary” is not necessarily to be construed as preferred or advantageous over other embodiments or designs.", "Rather, use of the word example or exemplary is intended to present concepts in a concrete fashion.", "As used in this application, the term “or” is intended to mean an inclusive “or” rather than an exclusive “or”.", "That is, unless specified otherwise or clear from context, “X employs A or B” is intended to mean any of the natural inclusive permutations.", "That is, if X employs A; X employs B; or X employs both A and B, then “X employs A or B” is satisfied under any of the foregoing instances.", "In addition, the articles “a” and “an” as used in this application and the appended claims should generally be construed to mean “one or more” unless specified otherwise or clear from context to be directed to a singular form.", "Moreover, terms such as “user equipment,” “mobile station,” “mobile,” subscriber station,” “access terminal,” “terminal,” “handset,” “mobile device” (and/or terms representing similar terminology) can refer to a wireless device utilized by a subscriber or user of a wireless communication service to receive or convey data, control, voice, video, sound, gaming or substantially any data-stream or signaling-stream.", "The foregoing terms are utilized interchangeably herein and with reference to the related drawings.", "Furthermore, the terms “user,” “subscriber,” “customer,” “consumer” and the like are employed interchangeably throughout, unless context warrants particular distinctions among the terms.", "It should be appreciated that such terms can refer to human entities or automated components supported through artificial intelligence (e.g., a capacity to make inference based, at least, on complex mathematical formalisms), which can provide simulated vision, sound recognition and so forth.", "As employed herein, the term “processor” can refer to substantially any computing processing unit or device comprising, but not limited to comprising, single-core processors; single-processors with software multithread execution capability; multi-core processors; multi-core processors with software multithread execution capability; multi-core processors with hardware multithread technology; parallel platforms; and parallel platforms with distributed shared memory.", "Additionally, a processor can refer to an integrated circuit, an application specific integrated circuit (ASIC), a digital signal processor (DSP), a field programmable gate array (FPGA), a programmable logic controller (PLC), a complex programmable logic device (CPLD), a discrete gate or transistor logic, discrete hardware components or any combination thereof designed to perform the functions described herein.", "Processors can exploit nano-scale architectures such as, but not limited to, molecular and quantum-dot based transistors, switches and gates, in order to optimize space usage or enhance performance of user equipment.", "A processor can also be implemented as a combination of computing processing units.", "As used herein, terms such as “data storage,” data storage,” “database,” and substantially any other information storage component relevant to operation and functionality of a component, refer to “memory components,” or entities embodied in a “memory” or components comprising the memory.", "It will be appreciated that the memory components or computer-readable storage media, described herein can be either volatile memory or nonvolatile memory or can include both volatile and nonvolatile memory.", "What has been described above includes mere examples of various embodiments.", "It is, of course, not possible to describe every conceivable combination of components or methodologies for purposes of describing these examples, but one of ordinary skill in the art can recognize that many further combinations and permutations of the present embodiments are possible.", "Accordingly, the embodiments disclosed and/or claimed herein are intended to embrace all such alterations, modifications and variations that fall within the spirit and scope of the appended claims.", "Furthermore, to the extent that the term “includes” is used in either the detailed description or the claims, such term is intended to be inclusive in a manner similar to the term “comprising” as “comprising” is interpreted when employed as a transitional word in a claim.", "In addition, a flow diagram may include a “start” and/or “continue” indication.", "The “start” and “continue” indications reflect that the steps presented can optionally be incorporated in or otherwise used in conjunction with other routines.", "In this context, “start” indicates the beginning of the first step presented and may be preceded by other activities not specifically shown.", "Further, the “continue” indication reflects that the steps presented may be performed multiple times and/or may be succeeded by other activities not specifically shown.", "Further, while a flow diagram indicates a particular ordering of steps, other orderings are likewise possible provided that the principles of causality are maintained.", "As may also be used herein, the term(s) “operably coupled to”, “coupled to”, and/or “coupling” includes direct coupling between items and/or indirect coupling between items via one or more intervening items.", "Such items and intervening items include, but are not limited to, junctions, communication paths, components, circuit elements, circuits, functional blocks, and/or devices.", "As an example of indirect coupling, a signal conveyed from a first item to a second item may be modified by one or more intervening items by modifying the form, nature or format of information in a signal, while one or more elements of the information in the signal are nevertheless conveyed in a manner than can be recognized by the second item.", "In a further example of indirect coupling, an action in a first item can cause a reaction on the second item, as a result of actions and/or reactions in one or more intervening items.", "Although specific embodiments have been illustrated and described herein, it should be appreciated that any arrangement which achieves the same or similar purpose may be substituted for the embodiments described or shown by the subject disclosure.", "The subject disclosure is intended to cover any and all adaptations or variations of various embodiments.", "Combinations of the above embodiments, and other embodiments not specifically described herein, can be used in the subject disclosure.", "For instance, one or more features from one or more embodiments can be combined with one or more features of one or more other embodiments.", "In one or more embodiments, features that are positively recited can also be negatively recited and excluded from the embodiment with or without replacement by another structural and/or functional feature.", "The steps or functions described with respect to the embodiments of the subject disclosure can be performed in any order.", "The steps or functions described with respect to the embodiments of the subject disclosure can be performed alone or in combination with other steps or functions of the subject disclosure, as well as from other embodiments or from other steps that have not been described in the subject disclosure.", "Further, more than or less than all of the features described with respect to an embodiment can also be utilized." ] ]
Patent_15874082
[ [ "METHOD AND APPARATUS FOR EXCHANGING COMMUNICATION SIGNALS", "Aspects of the subject disclosure may include, for example, detecting an environmental condition that can adversely affect operations of a waveguide system for transmitting or receiving electromagnetic waves guided by a transmission medium, and enabling a heater system to mitigate an effect of the environmental condition on the operations of the waveguide system for transmitting or receiving the electromagnetic waves.", "Other embodiments are disclosed." ], [ "1.A method, comprising: detecting, by a waveguide system, an environmental condition that affects transmitting or receiving electromagnetic waves guided by a transmission medium without requiring an electrical return path, wherein the waveguide system comprises a coupler for transmitting or receiving the electromagnetic waves and wherein the coupler is not coaxially aligned with the transmission medium; and enabling, by the waveguide system, a heating system of the waveguide system to mitigate an effect of the environmental condition on the transmitting or receiving the electromagnetic waves.", "2.The method of claim 1, wherein the environmental condition comprises a temperature measured by a temperature sensor of the waveguide system.", "3.The method of claim 2, wherein the temperature comprises an ambient temperature in a vicinity of the waveguide system.", "4.The method of claim 2, wherein the temperature comprises a temperature inside a housing assembly of the waveguide system.", "5.The method of claim 1, wherein the environmental condition comprises an accumulation of snow on an outer surface of a housing assembly of the waveguide system determined by imaging data supplied by an image sensor of the waveguide system.", "6.The method of claim 1, wherein the environmental condition comprises an accumulation of ice on an outer surface of a housing assembly of the waveguide system determined by imaging data supplied by an image sensor of the waveguide system.", "7.The method of claim 1, wherein the heating system comprises an inductive coupler that inductively generates a current from a power signal carried by the transmission medium.", "8.The method of claim 7, wherein the inductive coupler comprises a toroidal inductor that surrounds at least a portion of the transmission medium and an insulator that insulates the toroidal inductor from a conductive layer of the transmission medium.", "9.The method of claim 7, wherein the current is supplied to a circuit of the heating system that causes a heating element to emit heat.", "10.The method of claim 9, wherein the heating system further comprises a controllable switch to enable or disable the circuit of the heating system.", "11.The method of claim 10, wherein the enabling the heating system comprises providing, by the waveguide system, a signal to the controllable switch to enable the circuit of the heating system.", "12.A waveguide system, comprising: a launcher that operates by transmitting electromagnetic waves that are guided by a transmission medium, wherein the launcher is not coaxially aligned with the transmission medium; a sensor that facilitates generation of sensor data indicating an environmental condition that adversely affects the transmitting of the electromagnetic waves; a heating system that facilitates generation of heat; and a circuit, coupled to the sensor and the heating system, that facilitates detection of the environmental condition based on the sensor data, and enablement of the heating system to mitigate an effect of the environmental condition on the transmitting of the electromagnetic waves.", "13.The waveguide system of claim 12, wherein the sensor comprises a temperature sensor, and wherein the environmental condition comprises a temperature measured by the temperature sensor.", "14.The waveguide system of claim 13, wherein the temperature comprises a measure of ambient temperature in a vicinity of the waveguide system, a temperature inside a housing assembly of the waveguide system, or a combination thereof.", "15.The waveguide system of claim 12, wherein the sensor comprises an image sensor, wherein the environmental condition comprises an accumulation of snow or ice on an outer surface of a housing assembly of the waveguide system, and wherein the environmental condition is detected according to imaging data supplied by the image sensor.", "16.The waveguide system of claim 12, wherein the heating system comprises an inductive coupler and a heating element, wherein the inductive coupler inductively generates a current from a power signal carried by the transmission medium, and wherein the current is supplied to the heating element to generate the heat.", "17.The waveguide system of claim 16, wherein the heating element or the inductive coupler comprises a switch for enabling or disabling the current generated by the inductive coupler, and wherein the enablement of the heating system comprises supplying a signal to the switch to enable the current to flow to the heating element.", "18.A machine-readable storage medium comprising executable instructions that, when executed by a processor of a waveguide system, facilitate performance of operations comprising: detecting, by the waveguide system, an environmental condition that adversely affects transmitting or receiving electromagnetic waves guided by a transmission medium, wherein the waveguide system comprises a coupler that is not coaxially aligned with the transmission medium; and enabling, by the waveguide system, a heating system to mitigate an effect of the environmental condition on the transmitting or receiving the electromagnetic waves.", "19.The machine-readable storage medium of claim 18, wherein the environmental condition comprises a measure of ambient temperature in a vicinity of the waveguide system, a measure of temperature inside a housing assembly of the waveguide system, an accumulation of snow or ice on an outer surface of the housing assembly of the waveguide system, or any combinations thereof.", "20.The machine-readable storage medium of claim 18, wherein the heating system comprises an inductive coupler and a heating element, and wherein the enabling the heating system comprises enabling a switch that controls a current flow between the inductive coupler and the heating element." ], [ "<SOH> BACKGROUND <EOH>As smart phones and other portable devices increasingly become ubiquitous, and data usage increases, macrocell base station devices and existing wireless infrastructure in turn require higher bandwidth capability in order to address the increased demand.", "To provide additional mobile bandwidth, small cell deployment is being pursued, with microcells and picocells providing coverage for much smaller areas than traditional macrocells.", "In addition, most homes and businesses have grown to rely on broadband data access for services such as voice, video and Internet browsing, etc.", "Broadband access networks include satellite, 4G or 5G wireless, power line communication, fiber, cable, and telephone networks." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Reference will now be made to the accompanying drawings, which are not necessarily drawn to scale, and wherein: FIG.", "1 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIG.", "2 is a block diagram illustrating an example, non-limiting embodiment of a transmission device in accordance with various aspects described herein.", "FIG.", "3 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "4 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "5A is a graphical diagram illustrating an example, non-limiting embodiment of a frequency response in accordance with various aspects described herein.", "FIG.", "5B is a graphical diagram illustrating example, non-limiting embodiments of a longitudinal cross-section of an insulated wire depicting fields of guided electromagnetic waves at various operating frequencies in accordance with various aspects described herein.", "FIG.", "6 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "7 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "8 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "9A is a block diagram illustrating an example, non-limiting embodiment of a stub coupler in accordance with various aspects described herein.", "FIG.", "9B is a diagram illustrating an example, non-limiting embodiment of an electromagnetic distribution in accordance with various aspects described herein.", "FIGS.", "10A and 10B are block diagrams illustrating example, non-limiting embodiments of couplers and transceivers in accordance with various aspects described herein.", "FIG.", "11 is a block diagram illustrating an example, non-limiting embodiment of a dual stub coupler in accordance with various aspects described herein.", "FIG.", "12 is a block diagram illustrating an example, non-limiting embodiment of a repeater system in accordance with various aspects described herein.", "FIG.", "13 illustrates a block diagram illustrating an example, non-limiting embodiment of a bidirectional repeater in accordance with various aspects described herein.", "FIG.", "14 is a block diagram illustrating an example, non-limiting embodiment of a waveguide system in accordance with various aspects described herein.", "FIG.", "15 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIGS.", "16A, 16B and 16C are block diagrams illustrating an example, non-limiting embodiment of a system for managing a communication system in accordance with various aspects described herein.", "FIG.", "16D illustrates a flow diagram of an example, non-limiting embodiment of a method in accordance with various aspects described herein.", "FIG.", "17A illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A, 16B, and 16C .", "FIG.", "17B illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A, 16B, and 16C .", "FIG.", "18 illustrates a block diagram illustrating an example, non-limiting embodiment of a cross-sectional view of transmission media in accordance with various aspects described herein.", "FIG.", "19 illustrates a block diagram illustrating an example, non-limiting embodiment of spacing device for coupling to the transmission media in accordance with various aspects described herein.", "FIG.", "20 illustrates a flow diagram of an example, non-limiting embodiment of a method in accordance with various aspects described herein.", "FIG.", "21 is a block diagram of an example, non-limiting embodiment of a computing environment in accordance with various aspects described herein.", "FIG.", "22 is a block diagram of an example, non-limiting embodiment of a mobile network platform in accordance with various aspects described herein.", "FIG.", "23 is a block diagram of an example, non-limiting embodiment of a communication device in accordance with various aspects described herein.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is Continuation of and claims priority to U.S. patent application Ser.", "No.", "14/807,232, filed Jul.", "23, 2015, the contents of which is hereby incorporated by reference into this application as if set forth herein in full.", "FIELD OF THE DISCLOSURE The subject disclosure relates to guided electromagnetic wave communications.", "BACKGROUND As smart phones and other portable devices increasingly become ubiquitous, and data usage increases, macrocell base station devices and existing wireless infrastructure in turn require higher bandwidth capability in order to address the increased demand.", "To provide additional mobile bandwidth, small cell deployment is being pursued, with microcells and picocells providing coverage for much smaller areas than traditional macrocells.", "In addition, most homes and businesses have grown to rely on broadband data access for services such as voice, video and Internet browsing, etc.", "Broadband access networks include satellite, 4G or 5G wireless, power line communication, fiber, cable, and telephone networks.", "BRIEF DESCRIPTION OF THE DRAWINGS Reference will now be made to the accompanying drawings, which are not necessarily drawn to scale, and wherein: FIG.", "1 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIG.", "2 is a block diagram illustrating an example, non-limiting embodiment of a transmission device in accordance with various aspects described herein.", "FIG.", "3 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "4 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "5A is a graphical diagram illustrating an example, non-limiting embodiment of a frequency response in accordance with various aspects described herein.", "FIG.", "5B is a graphical diagram illustrating example, non-limiting embodiments of a longitudinal cross-section of an insulated wire depicting fields of guided electromagnetic waves at various operating frequencies in accordance with various aspects described herein.", "FIG.", "6 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "7 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "8 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "9A is a block diagram illustrating an example, non-limiting embodiment of a stub coupler in accordance with various aspects described herein.", "FIG.", "9B is a diagram illustrating an example, non-limiting embodiment of an electromagnetic distribution in accordance with various aspects described herein.", "FIGS.", "10A and 10B are block diagrams illustrating example, non-limiting embodiments of couplers and transceivers in accordance with various aspects described herein.", "FIG.", "11 is a block diagram illustrating an example, non-limiting embodiment of a dual stub coupler in accordance with various aspects described herein.", "FIG.", "12 is a block diagram illustrating an example, non-limiting embodiment of a repeater system in accordance with various aspects described herein.", "FIG.", "13 illustrates a block diagram illustrating an example, non-limiting embodiment of a bidirectional repeater in accordance with various aspects described herein.", "FIG.", "14 is a block diagram illustrating an example, non-limiting embodiment of a waveguide system in accordance with various aspects described herein.", "FIG.", "15 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIGS.", "16A, 16B and 16C are block diagrams illustrating an example, non-limiting embodiment of a system for managing a communication system in accordance with various aspects described herein.", "FIG.", "16D illustrates a flow diagram of an example, non-limiting embodiment of a method in accordance with various aspects described herein.", "FIG.", "17A illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A, 16B, and 16C.", "FIG.", "17B illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A, 16B, and 16C.", "FIG.", "18 illustrates a block diagram illustrating an example, non-limiting embodiment of a cross-sectional view of transmission media in accordance with various aspects described herein.", "FIG.", "19 illustrates a block diagram illustrating an example, non-limiting embodiment of spacing device for coupling to the transmission media in accordance with various aspects described herein.", "FIG.", "20 illustrates a flow diagram of an example, non-limiting embodiment of a method in accordance with various aspects described herein.", "FIG.", "21 is a block diagram of an example, non-limiting embodiment of a computing environment in accordance with various aspects described herein.", "FIG.", "22 is a block diagram of an example, non-limiting embodiment of a mobile network platform in accordance with various aspects described herein.", "FIG.", "23 is a block diagram of an example, non-limiting embodiment of a communication device in accordance with various aspects described herein.", "DETAILED DESCRIPTION One or more embodiments are now described with reference to the drawings, wherein like reference numerals are used to refer to like elements throughout.", "In the following description, for purposes of explanation, numerous details are set forth in order to provide a thorough understanding of the various embodiments.", "It is evident, however, that the various embodiments can be practiced without these details (and without applying to any particular networked environment or standard).", "In an embodiment, a guided wave communication system is presented for sending and receiving communication signals such as data or other signaling via guided electromagnetic waves.", "The guided electromagnetic waves include, for example, surface waves or other electromagnetic waves that are bound to or guided by a transmission medium.", "It will be appreciated that a variety of transmission media can be utilized with guided wave communications without departing from example embodiments.", "Examples of such transmission media can include one or more of the following, either alone or in one or more combinations: wires, whether insulated or not, and whether single-stranded or multi-stranded; conductors of other shapes or configurations including wire bundles, cables, rods, rails, pipes; non-conductors such as dielectric pipes, rods, rails, or other dielectric members; combinations of conductors and dielectric materials; or other guided wave transmission media.", "The inducement of guided electromagnetic waves on a transmission medium can be independent of any electrical potential, charge or current that is injected or otherwise transmitted through the transmission medium as part of an electrical circuit.", "For example, in the case where the transmission medium is a wire, it is to be appreciated that while a small current in the wire may be formed in response to the propagation of the guided waves along the wire, this can be due to the propagation of the electromagnetic wave along the wire surface, and is not formed in response to electrical potential, charge or current that is injected into the wire as part of an electrical circuit.", "The electromagnetic waves traveling on the wire therefore do not require a circuit to propagate along the wire surface.", "The wire therefore is a single wire transmission line that is not part of a circuit.", "Also, in some embodiments, a wire is not necessary, and the electromagnetic waves can propagate along a single line transmission medium that is not a wire.", "More generally, “guided electromagnetic waves” or “guided waves” as described by the subject disclosure are affected by the presence of a physical object that is at least a part of the transmission medium (e.g., a bare wire or other conductor, a dielectric, an insulated wire, a conduit or other hollow element, a bundle of insulated wires that is coated, covered or surrounded by a dielectric or insulator or other wire bundle, or another form of solid, liquid or otherwise non-gaseous transmission medium) so as to be at least partially bound to or guided by the physical object and so as to propagate along a transmission path of the physical object.", "Such a physical object can operate as at least a part of a transmission medium that guides, by way of an interface of the transmission medium (e.g., an outer surface, inner surface, an interior portion between the outer and the inner surfaces or other boundary between elements of the transmission medium), the propagation of guided electromagnetic waves, which in turn can carry energy, data and/or other signals along the transmission path from a sending device to a receiving device.", "Unlike free space propagation of wireless signals such as unguided (or unbounded) electromagnetic waves that decrease in intensity inversely by the square of the distance traveled by the unguided electromagnetic waves, guided electromagnetic waves can propagate along a transmission medium with less loss in magnitude per unit distance than experienced by unguided electromagnetic waves.", "Unlike electrical signals, guided electromagnetic waves can propagate from a sending device to a receiving device without requiring a separate electrical return path between the sending device and the receiving device.", "As a consequence, guided electromagnetic waves can propagate from a sending device to a receiving device along a transmission medium having no conductive components (e.g., a dielectric strip), or via a transmission medium having no more than a single conductor (e.g., a single bare wire or insulated wire).", "Even if a transmission medium includes one or more conductive components and the guided electromagnetic waves propagating along the transmission medium generate currents that flow in the one or more conductive components in a direction of the guided electromagnetic waves, such guided electromagnetic waves can propagate along the transmission medium from a sending device to a receiving device without requiring a flow of opposing currents on an electrical return path between the sending device and the receiving device.", "In a non-limiting illustration, consider electrical systems that transmit and receive electrical signals between sending and receiving devices by way of conductive media.", "Such systems generally rely on electrically separate forward and return paths.", "For instance, consider a coaxial cable having a center conductor and a ground shield that are separated by an insulator.", "Typically, in an electrical system a first terminal of a sending (or receiving) device can be connected to the center conductor, and a second terminal of the sending (or receiving) device can be connected to the ground shield.", "If the sending device injects an electrical signal in the center conductor via the first terminal, the electrical signal will propagate along the center conductor causing forward currents in the center conductor, and return currents in the ground shield.", "The same conditions apply for a two terminal receiving device.", "In contrast, consider a guided wave communication system such as described in the subject disclosure, which can utilize different embodiments of a transmission medium (including among others a coaxial cable) for transmitting and receiving guided electromagnetic waves without an electrical return path.", "In one embodiment, for example, the guided wave communication system of the subject disclosure can be configured to induce guided electromagnetic waves that propagate along an outer surface of a coaxial cable.", "Although the guided electromagnetic waves will cause forward currents on the ground shield, the guided electromagnetic waves do not require return currents to enable the guided electromagnetic waves to propagate along the outer surface of the coaxial cable.", "The same can be said of other transmission media used by a guided wave communication system for the transmission and reception of guided electromagnetic waves.", "For example, guided electromagnetic waves induced by the guided wave communication system on an outer surface of a bare wire, or an insulated wire can propagate along the bare wire or the insulated bare wire without an electrical return path.", "Consequently, electrical systems that require two or more conductors for carrying forward and reverse currents on separate conductors to enable the propagation of electrical signals injected by a sending device are distinct from guided wave systems that induce guided electromagnetic waves on an interface of a transmission medium without the need of an electrical return path to enable the propagation of the guided electromagnetic waves along the interface of the transmission medium.", "It is further noted that guided electromagnetic waves as described in the subject disclosure can have an electromagnetic field structure that lies primarily or substantially outside of a transmission medium so as to be bound to or guided by the transmission medium and so as to propagate non-trivial distances on or along an outer surface of the transmission medium.", "In other embodiments, guided electromagnetic waves can have an electromagnetic field structure that lies primarily or substantially inside a transmission medium so as to be bound to or guided by the transmission medium and so as to propagate non-trivial distances within the transmission medium.", "In other embodiments, guided electromagnetic waves can have an electromagnetic field structure that lies partially inside and partially outside a transmission medium so as to be bound to or guided by the transmission medium and so as to propagate non-trivial distances along the transmission medium.", "The desired electronic field structure in an embodiment may vary based upon a variety of factors, including the desired transmission distance, the characteristics of the transmission medium itself, and environmental conditions/characteristics outside of the transmission medium (e.g., presence of rain, fog, atmospheric conditions, etc.).", "Various embodiments described herein relate to coupling devices, that can be referred to as “waveguide coupling devices”, “waveguide couplers” or more simply as “couplers”, “coupling devices” or “launchers” for launching and/or extracting guided electromagnetic waves to and from a transmission medium at millimeter-wave frequencies (e.g., 30 to 300 GHz), wherein the wavelength can be small compared to one or more dimensions of the coupling device and/or the transmission medium such as the circumference of a wire or other cross sectional dimension, or lower microwave frequencies such as 300 MHz to 30 GHz.", "Transmissions can be generated to propagate as waves guided by a coupling device, such as: a strip, arc or other length of dielectric material; a horn, monopole, rod, slot or other antenna; an array of antennas; a magnetic resonant cavity, or other resonant coupler; a coil, a strip line, a waveguide or other coupling device.", "In operation, the coupling device receives an electromagnetic wave from a transmitter or transmission medium.", "The electromagnetic field structure of the electromagnetic wave can be carried inside the coupling device, outside the coupling device or some combination thereof.", "When the coupling device is in close proximity to a transmission medium, at least a portion of an electromagnetic wave couples to or is bound to the transmission medium, and continues to propagate as guided electromagnetic waves.", "In a reciprocal fashion, a coupling device can extract guided waves from a transmission medium and transfer these electromagnetic waves to a receiver.", "According to an example embodiment, a surface wave is a type of guided wave that is guided by a surface of a transmission medium, such as an exterior or outer surface of the wire, or another surface of the wire that is adjacent to or exposed to another type of medium having different properties (e.g., dielectric properties).", "Indeed, in an example embodiment, a surface of the wire that guides a surface wave can represent a transitional surface between two different types of media.", "For example, in the case of a bare or uninsulated wire, the surface of the wire can be the outer or exterior conductive surface of the bare or uninsulated wire that is exposed to air or free space.", "As another example, in the case of insulated wire, the surface of the wire can be the conductive portion of the wire that meets the insulator portion of the wire, or can otherwise be the insulator surface of the wire that is exposed to air or free space, or can otherwise be any material region between the insulator surface of the wire and the conductive portion of the wire that meets the insulator portion of the wire, depending upon the relative differences in the properties (e.g., dielectric properties) of the insulator, air, and/or the conductor and further dependent on the frequency and propagation mode or modes of the guided wave.", "According to an example embodiment, the term “about” a wire or other transmission medium used in conjunction with a guided wave can include fundamental guided wave propagation modes such as a guided waves having a circular or substantially circular field distribution, a symmetrical electromagnetic field distribution (e.g., electric field, magnetic field, electromagnetic field, etc.)", "or other fundamental mode pattern at least partially around a wire or other transmission medium.", "In addition, when a guided wave propagates “about” a wire or other transmission medium, it can do so according to a guided wave propagation mode that includes not only the fundamental wave propagation modes (e.g., zero order modes), but additionally or alternatively non-fundamental wave propagation modes such as higher-order guided wave modes (e.g., 1st order modes, 2nd order modes, etc.", "), asymmetrical modes and/or other guided (e.g., surface) waves that have non-circular field distributions around a wire or other transmission medium.", "As used herein, the term “guided wave mode” refers to a guided wave propagation mode of a transmission medium, coupling device or other system component of a guided wave communication system.", "For example, such non-circular field distributions can be unilateral or multi-lateral with one or more axial lobes characterized by relatively higher field strength and/or one or more nulls or null regions characterized by relatively low-field strength, zero-field strength or substantially zero-field strength.", "Further, the field distribution can otherwise vary as a function of azimuthal orientation around the wire such that one or more angular regions around the wire have an electric or magnetic field strength (or combination thereof) that is higher than one or more other angular regions of azimuthal orientation, according to an example embodiment.", "It will be appreciated that the relative orientations or positions of the guided wave higher order modes or asymmetrical modes can vary as the guided wave travels along the wire.", "As used herein, the term “millimeter-wave” can refer to electromagnetic waves/signals that fall within the “millimeter-wave frequency band” of 30 GHz to 300 GHz.", "The term “microwave” can refer to electromagnetic waves/signals that fall within a “microwave frequency band” of 300 MHz to 300 GHz.", "The term “radio frequency” or “RF” can refer to electromagnetic waves/signals that fall within the “radio frequency band” of 10 kHz to 1 THz.", "It is appreciated that wireless signals, electrical signals, and guided electromagnetic waves as described in the subject disclosure can be configured to operate at any desirable frequency range, such as, for example, at frequencies within, above or below millimeter-wave and/or microwave frequency bands.", "In particular, when a coupling device or transmission medium includes a conductive element, the frequency of the guided electromagnetic waves that are carried by the coupling device and/or propagate along the transmission medium can be below the mean collision frequency of the electrons in the conductive element.", "Further, the frequency of the guided electromagnetic waves that are carried by the coupling device and/or propagate along the transmission medium can be a non-optical frequency, e.g., a radio frequency below the range of optical frequencies that begins at 1 THz.", "As used herein, the term “antenna” can refer to a device that is part of a transmitting or receiving system to transmit/radiate or receive wireless signals.", "In accordance with one or more embodiments, a method can include detecting, by a waveguide system, a change in an environmental condition that can affect operations of the waveguide system for transmitting or receiving electromagnetic waves via a transmission medium without an electrical return path, and enabling, by the waveguide system, a heating system of the waveguide system to mitigate an effect of the environmental condition on the operations of the waveguide system for transmitting or receiving the electromagnetic waves.", "In accordance with one or more embodiments, a waveguide system can include a launcher that operates by transmitting electromagnetic waves that are guided by a transmission medium, a sensor that facilitates generation of sensor data indicating an environmental condition that can adversely affect operations of the launcher, a heating system that facilitates generation of heat, and a circuit, coupled to the sensor and the heating system, that facilitates detection of the environmental condition based on the sensor data, and enablement of the heating system to mitigate an effect of the environmental condition on the operations of the launcher for transmitting the electromagnetic waves.", "In accordance with one or more embodiments, a machine-readable storage medium can include executable instructions that, when executed by a processor, facilitate performance of operations.", "The operations can include detecting an environmental condition that can adversely affect operations of a waveguide system for transmitting or receiving electromagnetic waves guided by a transmission medium, and enabling a heater system to mitigate an effect of the environmental condition on the operations of the waveguide system for transmitting or receiving the electromagnetic waves.", "Referring now to FIG.", "1, a block diagram 100 illustrating an example, non-limiting embodiment of a guided wave communications system is shown.", "In operation, a transmission device 101 receives one or more communication signals 110 from a communication network or other communications device that includes data and generates guided waves 120 to convey the data via the transmission medium 125 to the transmission device 102.The transmission device 102 receives the guided waves 120 and converts them to communication signals 112 that include the data for transmission to a communications network or other communications device.", "The guided waves 120 can be modulated to convey data via a modulation technique such as phase shift keying, frequency shift keying, quadrature amplitude modulation, amplitude modulation, multi-carrier modulation such as orthogonal frequency division multiplexing and via multiple access techniques such as frequency division multiplexing, time division multiplexing, code division multiplexing, multiplexing via differing wave propagation modes and via other modulation and access strategies.", "The communication network or networks can include a wireless communication network such as a mobile data network, a cellular voice and data network, a wireless local area network (e.g., Wi-Fi or an 802.xx network), a satellite communications network, a personal area network or other wireless network.", "The communication network or networks can also include a wired communication network such as a telephone network, an Ethernet network, a local area network, a wide area network such as the Internet, a broadband access network, a cable network, a fiber optic network, or other wired network.", "The communication devices can include a network edge device, bridge device or home gateway, a set-top box, broadband modem, telephone adapter, access point, base station, or other fixed communication device, a mobile communication device such as an automotive gateway or automobile, laptop computer, tablet, smartphone, cellular telephone, or other communication device.", "In an example embodiment, the guided wave communication system 100 can operate in a bi-directional fashion where transmission device 102 receives one or more communication signals 112 from a communication network or device that includes other data and generates guided waves 122 to convey the other data via the transmission medium 125 to the transmission device 101.In this mode of operation, the transmission device 101 receives the guided waves 122 and converts them to communication signals 110 that include the other data for transmission to a communications network or device.", "The guided waves 122 can be modulated to convey data via a modulation technique such as phase shift keying, frequency shift keying, quadrature amplitude modulation, amplitude modulation, multi-carrier modulation such as orthogonal frequency division multiplexing and via multiple access techniques such as frequency division multiplexing, time division multiplexing, code division multiplexing, multiplexing via differing wave propagation modes and via other modulation and access strategies.", "The transmission medium 125 can include a cable having at least one inner portion surrounded by a dielectric material such as an insulator or other dielectric cover, coating or other dielectric material, the dielectric material having an outer surface and a corresponding circumference.", "In an example embodiment, the transmission medium 125 operates as a single-wire transmission line to guide the transmission of an electromagnetic wave.", "When the transmission medium 125 is implemented as a single wire transmission system, it can include a wire.", "The wire can be insulated or uninsulated, and single-stranded or multi-stranded (e.g., braided).", "In other embodiments, the transmission medium 125 can contain conductors of other shapes or configurations including wire bundles, cables, rods, rails, pipes.", "In addition, the transmission medium 125 can include non-conductors such as dielectric pipes, rods, rails, or other dielectric members; combinations of conductors and dielectric materials, conductors without dielectric materials or other guided wave transmission media.", "It should be noted that the transmission medium 125 can otherwise include any of the transmission media previously discussed.", "Further, as previously discussed, the guided waves 120 and 122 can be contrasted with radio transmissions over free space/air or conventional propagation of electrical power or signals through the conductor of a wire via an electrical circuit.", "In addition to the propagation of guided waves 120 and 122, the transmission medium 125 may optionally contain one or more wires that propagate electrical power or other communication signals in a conventional manner as a part of one or more electrical circuits.", "Referring now to FIG.", "2, a block diagram 200 illustrating an example, non-limiting embodiment of a transmission device is shown.", "The transmission device 101 or 102 includes a communications interface (I/F) 205, a transceiver 210 and a coupler 220.In an example of operation, the communications interface 205 receives a communication signal 110 or 112 that includes data.", "In various embodiments, the communications interface 205 can include a wireless interface for receiving a wireless communication signal in accordance with a wireless standard protocol such as LTE or other cellular voice and data protocol, Wi-Fi or an 802.11 protocol, WIMAX protocol, Ultra-Wideband protocol, Bluetooth protocol, ZigBee protocol, a direct broadcast satellite (DBS) or other satellite communication protocol or other wireless protocol.", "In addition or in the alternative, the communications interface 205 includes a wired interface that operates in accordance with an Ethernet protocol, universal serial bus (USB) protocol, a data over cable service interface specification (DOCSIS) protocol, a digital subscriber line (DSL) protocol, a Firewire (IEEE 1394) protocol, or other wired protocol.", "In additional to standards-based protocols, the communications interface 205 can operate in conjunction with other wired or wireless protocol.", "In addition, the communications interface 205 can optionally operate in conjunction with a protocol stack that includes multiple protocol layers including a MAC protocol, transport protocol, application protocol, etc.", "In an example of operation, the transceiver 210 generates an electromagnetic wave based on the communication signal 110 or 112 to convey the data.", "The electromagnetic wave has at least one carrier frequency and at least one corresponding wavelength.", "The carrier frequency can be within a millimeter-wave frequency band of 30 GHz-300 GHz, such as 60 GHz or a carrier frequency in the range of 30-40 GHz or a lower frequency band of 300 MHz-30 GHz in the microwave frequency range such as 26-30 GHz, 11 GHz, 6 GHz or 3 GHz, but it will be appreciated that other carrier frequencies are possible in other embodiments.", "In one mode of operation, the transceiver 210 merely upconverts the communications signal or signals 110 or 112 for transmission of the electromagnetic signal in the microwave or millimeter-wave band as a guided electromagnetic wave that is guided by or bound to the transmission medium 125.In another mode of operation, the communications interface 205 either converts the communication signal 110 or 112 to a baseband or near baseband signal or extracts the data from the communication signal 110 or 112 and the transceiver 210 modulates a high-frequency carrier with the data, the baseband or near baseband signal for transmission.", "It should be appreciated that the transceiver 210 can modulate the data received via the communication signal 110 or 112 to preserve one or more data communication protocols of the communication signal 110 or 112 either by encapsulation in the payload of a different protocol or by simple frequency shifting.", "In the alternative, the transceiver 210 can otherwise translate the data received via the communication signal 110 or 112 to a protocol that is different from the data communication protocol or protocols of the communication signal 110 or 112.In an example of operation, the coupler 220 couples the electromagnetic wave to the transmission medium 125 as a guided electromagnetic wave to convey the communications signal or signals 110 or 112.While the prior description has focused on the operation of the transceiver 210 as a transmitter, the transceiver 210 can also operate to receive electromagnetic waves that convey other data from the single wire transmission medium via the coupler 220 and to generate communications signals 110 or 112, via communications interface 205 that includes the other data.", "Consider embodiments where an additional guided electromagnetic wave conveys other data that also propagates along the transmission medium 125.The coupler 220 can also couple this additional electromagnetic wave from the transmission medium 125 to the transceiver 210 for reception.", "The transmission device 101 or 102 includes an optional training controller 230.In an example embodiment, the training controller 230 is implemented by a standalone processor or a processor that is shared with one or more other components of the transmission device 101 or 102.The training controller 230 selects the carrier frequencies, modulation schemes and/or guided wave modes for the guided electromagnetic waves based on feedback data received by the transceiver 210 from at least one remote transmission device coupled to receive the guided electromagnetic wave.", "In an example embodiment, a guided electromagnetic wave transmitted by a remote transmission device 101 or 102 conveys data that also propagates along the transmission medium 125.The data from the remote transmission device 101 or 102 can be generated to include the feedback data.", "In operation, the coupler 220 also couples the guided electromagnetic wave from the transmission medium 125 and the transceiver receives the electromagnetic wave and processes the electromagnetic wave to extract the feedback data.", "In an example embodiment, the training controller 230 operates based on the feedback data to evaluate a plurality of candidate frequencies, modulation schemes and/or transmission modes to select a carrier frequency, modulation scheme and/or transmission mode to enhance performance, such as throughput, signal strength, reduce propagation loss, etc.", "Consider the following example: a transmission device 101 begins operation under control of the training controller 230 by sending a plurality of guided waves as test signals such as pilot waves or other test signals at a corresponding plurality of candidate frequencies and/or candidate modes directed to a remote transmission device 102 coupled to the transmission medium 125.The guided waves can include, in addition or in the alternative, test data.", "The test data can indicate the particular candidate frequency and/or guide-wave mode of the signal.", "In an embodiment, the training controller 230 at the remote transmission device 102 receives the test signals and/or test data from any of the guided waves that were properly received and determines the best candidate frequency and/or guided wave mode, a set of acceptable candidate frequencies and/or guided wave modes, or a rank ordering of candidate frequencies and/or guided wave modes.", "This selection of candidate frequenc(ies) or/and guided-mode(s) are generated by the training controller 230 based on one or more optimizing criteria such as received signal strength, bit error rate, packet error rate, signal to noise ratio, propagation loss, etc.", "The training controller 230 generates feedback data that indicates the selection of candidate frequenc(ies) or/and guided wave mode(s) and sends the feedback data to the transceiver 210 for transmission to the transmission device 101.The transmission device 101 and 102 can then communicate data with one another based on the selection of candidate frequenc(ies) or/and guided wave mode(s).", "In other embodiments, the guided electromagnetic waves that contain the test signals and/or test data are reflected back, repeated back or otherwise looped back by the remote transmission device 102 to the transmission device 101 for reception and analysis by the training controller 230 of the transmission device 101 that initiated these waves.", "For example, the transmission device 101 can send a signal to the remote transmission device 102 to initiate a test mode where a physical reflector is switched on the line, a termination impedance is changed to cause reflections, a loop back mode is switched on to couple electromagnetic waves back to the source transmission device 102, and/or a repeater mode is enabled to amplify and retransmit the electromagnetic waves back to the source transmission device 102.The training controller 230 at the source transmission device 102 receives the test signals and/or test data from any of the guided waves that were properly received and determines selection of candidate frequenc(ies) or/and guided wave mode(s).", "While the procedure above has been described in a start-up or initialization mode of operation, each transmission device 101 or 102 can send test signals, evaluate candidate frequencies or guided wave modes via non-test such as normal transmissions or otherwise evaluate candidate frequencies or guided wave modes at other times or continuously as well.", "In an example embodiment, the communication protocol between the transmission devices 101 and 102 can include an on-request or periodic test mode where either full testing or more limited testing of a subset of candidate frequencies and guided wave modes are tested and evaluated.", "In other modes of operation, the re-entry into such a test mode can be triggered by a degradation of performance due to a disturbance, weather conditions, etc.", "In an example embodiment, the receiver bandwidth of the transceiver 210 is either sufficiently wide or swept to receive all candidate frequencies or can be selectively adjusted by the training controller 230 to a training mode where the receiver bandwidth of the transceiver 210 is sufficiently wide or swept to receive all candidate frequencies.", "Referring now to FIG.", "3, a graphical diagram 300 illustrating an example, non-limiting embodiment of an electromagnetic field distribution is shown.", "In this embodiment, a transmission medium 125 in air includes an inner conductor 301 and an insulating jacket 302 of dielectric material, as shown in cross section.", "The diagram 300 includes different gray-scales that represent differing electromagnetic field strengths generated by the propagation of the guided wave having an asymmetrical and non-fundamental guided wave mode.", "In particular, the electromagnetic field distribution corresponds to a modal “sweet spot” that enhances guided electromagnetic wave propagation along an insulated transmission medium and reduces end-to-end transmission loss.", "In this particular mode, electromagnetic waves are guided by the transmission medium 125 to propagate along an outer surface of the transmission medium—in this case, the outer surface of the insulating jacket 302.Electromagnetic waves are partially embedded in the insulator and partially radiating on the outer surface of the insulator.", "In this fashion, electromagnetic waves are “lightly” coupled to the insulator so as to enable electromagnetic wave propagation at long distances with low propagation loss.", "As shown, the guided wave has a field structure that lies primarily or substantially outside of the transmission medium 125 that serves to guide the electromagnetic waves.", "The regions inside the conductor 301 have little or no field.", "Likewise regions inside the insulating jacket 302 have low field strength.", "The majority of the electromagnetic field strength is distributed in the lobes 304 at the outer surface of the insulating jacket 302 and in close proximity thereof.", "The presence of an asymmetric guided wave mode is shown by the high electromagnetic field strengths at the top and bottom of the outer surface of the insulating jacket 302 (in the orientation of the diagram)—as opposed to very small field strengths on the other sides of the insulating jacket 302.The example shown corresponds to a 38 GHz electromagnetic wave guided by a wire with a diameter of 1.1 cm and a dielectric insulation of thickness of 0.36 cm.", "Because the electromagnetic wave is guided by the transmission medium 125 and the majority of the field strength is concentrated in the air outside of the insulating jacket 302 within a limited distance of the outer surface, the guided wave can propagate longitudinally down the transmission medium 125 with very low loss.", "In the example shown, this “limited distance” corresponds to a distance from the outer surface that is less than half the largest cross sectional dimension of the transmission medium 125.In this case, the largest cross sectional dimension of the wire corresponds to the overall diameter of 1.82 cm, however, this value can vary with the size and shape of the transmission medium 125.For example, should the transmission medium 125 be of a rectangular shape with a height of 0.3 cm and a width of 0.4 cm, the largest cross sectional dimension would be the diagonal of 0.5 cm and the corresponding limited distance would be 0.25 cm.", "The dimensions of the area containing the majority of the field strength also vary with the frequency, and in general, increase as carrier frequencies decrease.", "It should also be noted that the components of a guided wave communication system, such as couplers and transmission media can have their own cut-off frequencies for each guided wave mode.", "The cut-off frequency generally sets forth the lowest frequency that a particular guided wave mode is designed to be supported by that particular component.", "In an example embodiment, the particular asymmetric mode of propagation shown is induced on the transmission medium 125 by an electromagnetic wave having a frequency that falls within a limited range (such as Fc to 2Fc) of the lower cut-off frequency Fc for this particular asymmetric mode.", "The lower cut-off frequency Fc is particular to the characteristics of transmission medium 125.For embodiments as shown that include an inner conductor 301 surrounded by an insulating jacket 302, this cutoff frequency can vary based on the dimensions and properties of the insulating jacket 302 and potentially the dimensions and properties of the inner conductor 301 and can be determined experimentally to have a desired mode pattern.", "It should be noted however, that similar effects can be found for a hollow dielectric or insulator without an inner conductor.", "In this case, the cutoff frequency can vary based on the dimensions and properties of the hollow dielectric or insulator.", "At frequencies lower than the lower cut-off frequency, the asymmetric mode is difficult to induce in the transmission medium 125 and fails to propagate for all but trivial distances.", "As the frequency increases above the limited range of frequencies about the cut-off frequency, the asymmetric mode shifts more and more inward of the insulating jacket 302.At frequencies much larger than the cut-off frequency, the field strength is no longer concentrated outside of the insulating jacket, but primarily inside of the insulating jacket 302.While the transmission medium 125 provides strong guidance to the electromagnetic wave and propagation is still possible, ranges are more limited by increased losses due to propagation within the insulating jacket 302—as opposed to the surrounding air.", "Referring now to FIG.", "4, a graphical diagram 400 illustrating an example, non-limiting embodiment of an electromagnetic field distribution is shown.", "In particular, a cross section diagram 400, similar to FIG.", "3 is shown with common reference numerals used to refer to similar elements.", "The example shown corresponds to a 60 GHz wave guided by a wire with a diameter of 1.1 cm and a dielectric insulation of thickness of 0.36 cm.", "Because the frequency of the guided wave is above the limited range of the cut-off frequency of this particular asymmetric mode, much of the field strength has shifted inward of the insulating jacket 302.In particular, the field strength is concentrated primarily inside of the insulating jacket 302.While the transmission medium 125 provides strong guidance to the electromagnetic wave and propagation is still possible, ranges are more limited when compared with the embodiment of FIG.", "3, by increased losses due to propagation within the insulating jacket 302.Referring now to FIG.", "5A, a graphical diagram illustrating an example, non-limiting embodiment of a frequency response is shown.", "In particular, diagram 500 presents a graph of end-to-end loss (in dB) as a function of frequency, overlaid with electromagnetic field distributions 510, 520 and 530 at three points for a 200 cm insulated medium voltage wire.", "The boundary between the insulator and the surrounding air is represented by reference numeral 525 in each electromagnetic field distribution.", "As discussed in conjunction with FIG.", "3, an example of a desired asymmetric mode of propagation shown is induced on the transmission medium 125 by an electromagnetic wave having a frequency that falls within a limited range (such as Fc to 2Fc) of the lower cut-off frequency Fc of the transmission medium for this particular asymmetric mode.", "In particular, the electromagnetic field distribution 520 at 6 GHz falls within this modal “sweet spot” that enhances electromagnetic wave propagation along an insulated transmission medium and reduces end-to-end transmission loss.", "In this particular mode, guided waves are partially embedded in the insulator and partially radiating on the outer surface of the insulator.", "In this fashion, the electromagnetic waves are “lightly” coupled to the insulator so as to enable guided electromagnetic wave propagation at long distances with low propagation loss.", "At lower frequencies represented by the electromagnetic field distribution 510 at 3 GHz, the asymmetric mode radiates more heavily generating higher propagation losses.", "At higher frequencies represented by the electromagnetic field distribution 530 at 9 GHz, the asymmetric mode shifts more and more inward of the insulating jacket providing too much absorption, again generating higher propagation losses.", "Referring now to FIG.", "5B, a graphical diagram 550 illustrating example, non-limiting embodiments of a longitudinal cross-section of a transmission medium 125, such as an insulated wire, depicting fields of guided electromagnetic waves at various operating frequencies is shown.", "As shown in diagram 556, when the guided electromagnetic waves are at approximately the cutoff frequency (fc) corresponding to the modal “sweet spot”, the guided electromagnetic waves are loosely coupled to the insulated wire so that absorption is reduced, and the fields of the guided electromagnetic waves are bound sufficiently to reduce the amount radiated into the environment (e.g., air).", "Because absorption and radiation of the fields of the guided electromagnetic waves is low, propagation losses are consequently low, enabling the guided electromagnetic waves to propagate for longer distances.", "As shown in diagram 554, propagation losses increase when an operating frequency of the guide electromagnetic waves increases above about two-times the cutoff frequency (fc)—or as referred to, above the range of the “sweet spot”.", "More of the field strength of the electromagnetic wave is driven inside the insulating layer, increasing propagation losses.", "At frequencies much higher than the cutoff frequency (fc) the guided electromagnetic waves are strongly bound to the insulated wire as a result of the fields emitted by the guided electromagnetic waves being concentrated in the insulation layer of the wire, as shown in diagram 552.This in turn raises propagation losses further due to absorption of the guided electromagnetic waves by the insulation layer.", "Similarly, propagation losses increase when the operating frequency of the guided electromagnetic waves is substantially below the cutoff frequency (fc), as shown in diagram 558.At frequencies much lower than the cutoff frequency (fc) the guided electromagnetic waves are weakly (or nominally) bound to the insulated wire and thereby tend to radiate into the environment (e.g., air), which in turn, raises propagation losses due to radiation of the guided electromagnetic waves.", "Referring now to FIG.", "6, a graphical diagram 600 illustrating an example, non-limiting embodiment of an electromagnetic field distribution is shown.", "In this embodiment, a transmission medium 602 is a bare wire, as shown in cross section.", "The diagram 300 includes different gray-scales that represent differing electromagnetic field strengths generated by the propagation of a guided wave having a symmetrical and fundamental guided wave mode at a single carrier frequency.", "In this particular mode, electromagnetic waves are guided by the transmission medium 602 to propagate along an outer surface of the transmission medium—in this case, the outer surface of the bare wire.", "Electromagnetic waves are “lightly” coupled to the wire so as to enable electromagnetic wave propagation at long distances with low propagation loss.", "As shown, the guided wave has a field structure that lies substantially outside of the transmission medium 602 that serves to guide the electromagnetic waves.", "The regions inside the conductor 602 have little or no field.", "Referring now to FIG.", "7, a block diagram 700 illustrating an example, non-limiting embodiment of an arc coupler is shown.", "In particular a coupling device is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.The coupling device includes an arc coupler 704 coupled to a transmitter circuit 712 and termination or damper 714.The arc coupler 704 can be made of a dielectric material, or other low-loss insulator (e.g., Teflon, polyethylene, etc.", "), or made of a conducting (e.g., metallic, non-metallic, etc.)", "material, or any combination of the foregoing materials.", "As shown, the arc coupler 704 operates as a waveguide and has a wave 706 propagating as a guided wave about a waveguide surface of the arc coupler 704.In the embodiment shown, at least a portion of the arc coupler 704 can be placed near a wire 702 or other transmission medium, (such as transmission medium 125), in order to facilitate coupling between the arc coupler 704 and the wire 702 or other transmission medium, as described herein to launch the guided wave 708 on the wire.", "The arc coupler 704 can be placed such that a portion of the curved arc coupler 704 is tangential to, and parallel or substantially parallel to the wire 702.The portion of the arc coupler 704 that is parallel to the wire can be an apex of the curve, or any point where a tangent of the curve is parallel to the wire 702.When the arc coupler 704 is positioned or placed thusly, the wave 706 travelling along the arc coupler 704 couples, at least in part, to the wire 702, and propagates as guided wave 708 around or about the wire surface of the wire 702 and longitudinally along the wire 702.The guided wave 708 can be characterized as a surface wave or other electromagnetic wave that is guided by or bound to the wire 702 or other transmission medium.", "A portion of the wave 706 that does not couple to the wire 702 propagates as a wave 710 along the arc coupler 704.It will be appreciated that the arc coupler 704 can be configured and arranged in a variety of positions in relation to the wire 702 to achieve a desired level of coupling or non-coupling of the wave 706 to the wire 702.For example, the curvature and/or length of the arc coupler 704 that is parallel or substantially parallel, as well as its separation distance (which can include zero separation distance in an embodiment), to the wire 702 can be varied without departing from example embodiments.", "Likewise, the arrangement of arc coupler 704 in relation to the wire 702 may be varied based upon considerations of the respective intrinsic characteristics (e.g., thickness, composition, electromagnetic properties, etc.)", "of the wire 702 and the arc coupler 704, as well as the characteristics (e.g., frequency, energy level, etc.)", "of the waves 706 and 708.The guided wave 708 stays parallel or substantially parallel to the wire 702, even as the wire 702 bends and flexes.", "Bends in the wire 702 can increase transmission losses, which are also dependent on wire diameters, frequency, and materials.", "If the dimensions of the arc coupler 704 are chosen for efficient power transfer, most of the power in the wave 706 is transferred to the wire 702, with little power remaining in wave 710.It will be appreciated that the guided wave 708 can still be multi-modal in nature (discussed herein), including having modes that are non-fundamental or asymmetric, while traveling along a path that is parallel or substantially parallel to the wire 702, with or without a fundamental transmission mode.", "In an embodiment, non-fundamental or asymmetric modes can be utilized to minimize transmission losses and/or obtain increased propagation distances.", "It is noted that the term parallel is generally a geometric construct which often is not exactly achievable in real systems.", "Accordingly, the term parallel as utilized in the subject disclosure represents an approximation rather than an exact configuration when used to describe embodiments disclosed in the subject disclosure.", "In an embodiment, substantially parallel can include approximations that are within 30 degrees of true parallel in all dimensions.", "In an embodiment, the wave 706 can exhibit one or more wave propagation modes.", "The arc coupler modes can be dependent on the shape and/or design of the coupler 704.The one or more arc coupler modes of wave 706 can generate, influence, or impact one or more wave propagation modes of the guided wave 708 propagating along wire 702.It should be particularly noted however that the guided wave modes present in the guided wave 706 may be the same or different from the guided wave modes of the guided wave 708.In this fashion, one or more guided wave modes of the guided wave 706 may not be transferred to the guided wave 708, and further one or more guided wave modes of guided wave 708 may not have been present in guided wave 706.It should also be noted that the cut-off frequency of the arc coupler 704 for a particular guided wave mode may be different than the cutoff frequency of the wire 702 or other transmission medium for that same mode.", "For example, while the wire 702 or other transmission medium may be operated slightly above its cutoff frequency for a particular guided wave mode, the arc coupler 704 may be operated well above its cut-off frequency for that same mode for low loss, slightly below its cut-off frequency for that same mode to, for example, induce greater coupling and power transfer, or some other point in relation to the arc coupler's cutoff frequency for that mode.", "In an embodiment, the wave propagation modes on the wire 702 can be similar to the arc coupler modes since both waves 706 and 708 propagate about the outside of the arc coupler 704 and wire 702 respectively.", "In some embodiments, as the wave 706 couples to the wire 702, the modes can change form, or new modes can be created or generated, due to the coupling between the arc coupler 704 and the wire 702.For example, differences in size, material, and/or impedances of the arc coupler 704 and wire 702 may create additional modes not present in the arc coupler modes and/or suppress some of the arc coupler modes.", "The wave propagation modes can comprise the fundamental transverse electromagnetic mode (Quasi-TEM00), where only small electric and/or magnetic fields extend in the direction of propagation, and the electric and magnetic fields extend radially outwards while the guided wave propagates along the wire.", "This guided wave mode can be donut shaped, where few of the electromagnetic fields exist within the arc coupler 704 or wire 702.Waves 706 and 708 can comprise a fundamental TEM mode where the fields extend radially outwards, and also comprise other, non-fundamental (e.g., asymmetric, higher-level, etc.)", "modes.", "While particular wave propagation modes are discussed above, other wave propagation modes are likewise possible such as transverse electric (TE) and transverse magnetic (TM) modes, based on the frequencies employed, the design of the arc coupler 704, the dimensions and composition of the wire 702, as well as its surface characteristics, its insulation if present, the electromagnetic properties of the surrounding environment, etc.", "It should be noted that, depending on the frequency, the electrical and physical characteristics of the wire 702 and the particular wave propagation modes that are generated, guided wave 708 can travel along the conductive surface of an oxidized uninsulated wire, an unoxidized uninsulated wire, an insulated wire and/or along the insulating surface of an insulated wire.", "In an embodiment, a diameter of the arc coupler 704 is smaller than the diameter of the wire 702.For the millimeter-band wavelength being used, the arc coupler 704 supports a single waveguide mode that makes up wave 706.This single waveguide mode can change as it couples to the wire 702 as guided wave 708.If the arc coupler 704 were larger, more than one waveguide mode can be supported, but these additional waveguide modes may not couple to the wire 702 as efficiently, and higher coupling losses can result.", "However, in some alternative embodiments, the diameter of the arc coupler 704 can be equal to or larger than the diameter of the wire 702, for example, where higher coupling losses are desirable or when used in conjunction with other techniques to otherwise reduce coupling losses (e.g., impedance matching with tapering, etc.).", "In an embodiment, the wavelength of the waves 706 and 708 are comparable in size, or smaller than a circumference of the arc coupler 704 and the wire 702.In an example, if the wire 702 has a diameter of 0.5 cm, and a corresponding circumference of around 1.5 cm, the wavelength of the transmission is around 1.5 cm or less, corresponding to a frequency of 70 GHz or greater.", "In another embodiment, a suitable frequency of the transmission and the carrier-wave signal is in the range of 30-100 GHz, perhaps around 30-60 GHz, and around 38 GHz in one example.", "In an embodiment, when the circumference of the arc coupler 704 and wire 702 is comparable in size to, or greater, than a wavelength of the transmission, the waves 706 and 708 can exhibit multiple wave propagation modes including fundamental and/or non-fundamental (symmetric and/or asymmetric) modes that propagate over sufficient distances to support various communication systems described herein.", "The waves 706 and 708 can therefore comprise more than one type of electric and magnetic field configuration.", "In an embodiment, as the guided wave 708 propagates down the wire 702, the electrical and magnetic field configurations will remain the same from end to end of the wire 702.In other embodiments, as the guided wave 708 encounters interference (distortion or obstructions) or loses energy due to transmission losses or scattering, the electric and magnetic field configurations can change as the guided wave 708 propagates down wire 702.In an embodiment, the arc coupler 704 can be composed of nylon, Teflon, polyethylene, a polyamide, or other plastics.", "In other embodiments, other dielectric materials are possible.", "The wire surface of wire 702 can be metallic with either a bare metallic surface, or can be insulated using plastic, dielectric, insulator or other coating, jacket or sheathing.", "In an embodiment, a dielectric or otherwise non-conducting/insulated waveguide can be paired with either a bare/metallic wire or insulated wire.", "In other embodiments, a metallic and/or conductive waveguide can be paired with a bare/metallic wire or insulated wire.", "In an embodiment, an oxidation layer on the bare metallic surface of the wire 702 (e.g., resulting from exposure of the bare metallic surface to oxygen/air) can also provide insulating or dielectric properties similar to those provided by some insulators or sheathings.", "It is noted that the graphical representations of waves 706, 708 and 710 are presented merely to illustrate the principles that wave 706 induces or otherwise launches a guided wave 708 on a wire 702 that operates, for example, as a single wire transmission line.", "Wave 710 represents the portion of wave 706 that remains on the arc coupler 704 after the generation of guided wave 708.The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on the frequencies employed, the particular wave propagation mode or modes, the design of the arc coupler 704, the dimensions and composition of the wire 702, as well as its surface characteristics, its optional insulation, the electromagnetic properties of the surrounding environment, etc.", "It is noted that arc coupler 704 can include a termination circuit or damper 714 at the end of the arc coupler 704 that can absorb leftover radiation or energy from wave 710.The termination circuit or damper 714 can prevent and/or minimize the leftover radiation or energy from wave 710 reflecting back toward transmitter circuit 712.In an embodiment, the termination circuit or damper 714 can include termination resistors, and/or other components that perform impedance matching to attenuate reflection.", "In some embodiments, if the coupling efficiencies are high enough, and/or wave 710 is sufficiently small, it may not be necessary to use a termination circuit or damper 714.For the sake of simplicity, these transmitter 712 and termination circuits or dampers 714 may not be depicted in the other figures, but in those embodiments, transmitter and termination circuits or dampers may possibly be used.", "Further, while a single arc coupler 704 is presented that generates a single guided wave 708, multiple arc couplers 704 placed at different points along the wire 702 and/or at different azimuthal orientations about the wire can be employed to generate and receive multiple guided waves 708 at the same or different frequencies, at the same or different phases, at the same or different wave propagation modes.", "FIG.", "8, a block diagram 800 illustrating an example, non-limiting embodiment of an arc coupler is shown.", "In the embodiment shown, at least a portion of the coupler 704 can be placed near a wire 702 or other transmission medium, (such as transmission medium 125), in order to facilitate coupling between the arc coupler 704 and the wire 702 or other transmission medium, to extract a portion of the guided wave 806 as a guided wave 808 as described herein.", "The arc coupler 704 can be placed such that a portion of the curved arc coupler 704 is tangential to, and parallel or substantially parallel to the wire 702.The portion of the arc coupler 704 that is parallel to the wire can be an apex of the curve, or any point where a tangent of the curve is parallel to the wire 702.When the arc coupler 704 is positioned or placed thusly, the wave 806 travelling along the wire 702 couples, at least in part, to the arc coupler 704, and propagates as guided wave 808 along the arc coupler 704 to a receiving device (not expressly shown).", "A portion of the wave 806 that does not couple to the arc coupler propagates as wave 810 along the wire 702 or other transmission medium.", "In an embodiment, the wave 806 can exhibit one or more wave propagation modes.", "The arc coupler modes can be dependent on the shape and/or design of the coupler 704.The one or more modes of guided wave 806 can generate, influence, or impact one or more guide-wave modes of the guided wave 808 propagating along the arc coupler 704.It should be particularly noted however that the guided wave modes present in the guided wave 806 may be the same or different from the guided wave modes of the guided wave 808.In this fashion, one or more guided wave modes of the guided wave 806 may not be transferred to the guided wave 808, and further one or more guided wave modes of guided wave 808 may not have been present in guided wave 806.Referring now to FIG.", "9A, a block diagram 900 illustrating an example, non-limiting embodiment of a stub coupler is shown.", "In particular a coupling device that includes stub coupler 904 is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.The stub coupler 904 can be made of a dielectric material, or other low-loss insulator (e.g., Teflon, polyethylene and etc.", "), or made of a conducting (e.g., metallic, non-metallic, etc.)", "material, or any combination of the foregoing materials.", "As shown, the stub coupler 904 operates as a waveguide and has a wave 906 propagating as a guided wave about a waveguide surface of the stub coupler 904.In the embodiment shown, at least a portion of the stub coupler 904 can be placed near a wire 702 or other transmission medium, (such as transmission medium 125), in order to facilitate coupling between the stub coupler 904 and the wire 702 or other transmission medium, as described herein to launch the guided wave 908 on the wire.", "In an embodiment, the stub coupler 904 is curved, and an end of the stub coupler 904 can be tied, fastened, or otherwise mechanically coupled to a wire 702.When the end of the stub coupler 904 is fastened to the wire 702, the end of the stub coupler 904 is parallel or substantially parallel to the wire 702.Alternatively, another portion of the dielectric waveguide beyond an end can be fastened or coupled to wire 702 such that the fastened or coupled portion is parallel or substantially parallel to the wire 702.The fastener 910 can be a nylon cable tie or other type of non-conducting/dielectric material that is either separate from the stub coupler 904 or constructed as an integrated component of the stub coupler 904.The stub coupler 904 can be adjacent to the wire 702 without surrounding the wire 702.Like the arc coupler 704 described in conjunction with FIG.", "7, when the stub coupler 904 is placed with the end parallel to the wire 702, the guided wave 906 travelling along the stub coupler 904 couples to the wire 702, and propagates as guided wave 908 about the wire surface of the wire 702.In an example embodiment, the guided wave 908 can be characterized as a surface wave or other electromagnetic wave.", "It is noted that the graphical representations of waves 906 and 908 are presented merely to illustrate the principles that wave 906 induces or otherwise launches a guided wave 908 on a wire 702 that operates, for example, as a single wire transmission line.", "The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on one or more of the shape and/or design of the coupler, the relative position of the dielectric waveguide to the wire, the frequencies employed, the design of the stub coupler 904, the dimensions and composition of the wire 702, as well as its surface characteristics, its optional insulation, the electromagnetic properties of the surrounding environment, etc.", "In an embodiment, an end of stub coupler 904 can taper towards the wire 702 in order to increase coupling efficiencies.", "Indeed, the tapering of the end of the stub coupler 904 can provide impedance matching to the wire 702 and reduce reflections, according to an example embodiment of the subject disclosure.", "For example, an end of the stub coupler 904 can be gradually tapered in order to obtain a desired level of coupling between waves 906 and 908 as illustrated in FIG.", "9A.", "In an embodiment, the fastener 910 can be placed such that there is a short length of the stub coupler 904 between the fastener 910 and an end of the stub coupler 904.Maximum coupling efficiencies are realized in this embodiment when the length of the end of the stub coupler 904 that is beyond the fastener 910 is at least several wavelengths long for whatever frequency is being transmitted.", "Turning now to FIG.", "9B, a diagram 950 illustrating an example, non-limiting embodiment of an electromagnetic distribution in accordance with various aspects described herein is shown.", "In particular, an electromagnetic distribution is presented in two dimensions for a transmission device that includes coupler 952, shown in an example stub coupler constructed of a dielectric material.", "The coupler 952 couples an electromagnetic wave for propagation as a guided wave along an outer surface of a wire 702 or other transmission medium.", "The coupler 952 guides the electromagnetic wave to a junction at xo via a symmetrical guided wave mode.", "While some of the energy of the electromagnetic wave that propagates along the coupler 952 is outside of the coupler 952, the majority of the energy of this electromagnetic wave is contained within the coupler 952.The junction at xo couples the electromagnetic wave to the wire 702 or other transmission medium at an azimuthal angle corresponding to the bottom of the transmission medium.", "This coupling induces an electromagnetic wave that is guided to propagate along the outer surface of the wire 702 or other transmission medium via at least one guided wave mode in direction 956.The majority of the energy of the guided electromagnetic wave is outside or, but in close proximity to the outer surface of the wire 702 or other transmission medium.", "In the example shown, the junction at xo forms an electromagnetic wave that propagates via both a symmetrical mode and at least one asymmetrical surface mode, such as the first order mode presented in conjunction with FIG.", "3, that skims the surface of the wire 702 or other transmission medium.", "It is noted that the graphical representations of guided waves are presented merely to illustrate an example of guided wave coupling and propagation.", "The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on the frequencies employed, the design and/or configuration of the coupler 952, the dimensions and composition of the wire 702 or other transmission medium, as well as its surface characteristics, its insulation if present, the electromagnetic properties of the surrounding environment, etc.", "Turning now to FIG.", "10A, illustrated is a block diagram 1000 of an example, non-limiting embodiment of a coupler and transceiver system in accordance with various aspects described herein.", "The system is an example of transmission device 101 or 102.In particular, the communication interface 1008 is an example of communications interface 205, the stub coupler 1002 is an example of coupler 220, and the transmitter/receiver device 1006, diplexer 1016, power amplifier 1014, low noise amplifier 1018, frequency mixers 1010 and 1020 and local oscillator 1012 collectively form an example of transceiver 210.In operation, the transmitter/receiver device 1006 launches and receives waves (e.g., guided wave 1004 onto stub coupler 1002).", "The guided waves 1004 can be used to transport signals received from and sent to a host device, base station, mobile devices, a building or other device by way of a communications interface 1008.The communications interface 1008 can be an integral part of system 1000.Alternatively, the communications interface 1008 can be tethered to system 1000.The communications interface 1008 can comprise a wireless interface for interfacing to the host device, base station, mobile devices, a building or other device utilizing any of various wireless signaling protocols (e.g., LTE, Wi-Fi, WiMAX, IEEE 802.xx, etc.)", "including an infrared protocol such as an infrared data association (IrDA) protocol or other line of sight optical protocol.", "The communications interface 1008 can also comprise a wired interface such as a fiber optic line, coaxial cable, twisted pair, category 5 (CAT-5) cable or other suitable wired or optical mediums for communicating with the host device, base station, mobile devices, a building or other device via a protocol such as an Ethernet protocol, universal serial bus (USB) protocol, a data over cable service interface specification (DOCSIS) protocol, a digital subscriber line (DSL) protocol, a Firewire (IEEE 1394) protocol, or other wired or optical protocol.", "For embodiments where system 1000 functions as a repeater, the communications interface 1008 may not be necessary.", "The output signals (e.g., Tx) of the communications interface 1008 can be combined with a carrier wave (e.g., millimeter-wave carrier wave) generated by a local oscillator 1012 at frequency mixer 1010.Frequency mixer 1010 can use heterodyning techniques or other frequency shifting techniques to frequency shift the output signals from communications interface 1008.For example, signals sent to and from the communications interface 1008 can be modulated signals such as orthogonal frequency division multiplexed (OFDM) signals formatted in accordance with a Long-Term Evolution (LTE) wireless protocol or other wireless 3G, 4G, 5G or higher voice and data protocol, a ZigBee, WIMAX, Ultra-Wideband or IEEE 802.11 wireless protocol; a wired protocol such as an Ethernet protocol, universal serial bus (USB) protocol, a data over cable service interface specification (DOCSIS) protocol, a digital subscriber line (DSL) protocol, a Firewire (IEEE 1394) protocol or other wired or wireless protocol.", "In an example embodiment, this frequency conversion can be done in the analog domain, and as a result, the frequency shifting can be done without regard to the type of communications protocol used by a base station, mobile devices, or in-building devices.", "As new communications technologies are developed, the communications interface 1008 can be upgraded (e.g., updated with software, firmware, and/or hardware) or replaced and the frequency shifting and transmission apparatus can remain, simplifying upgrades.", "The carrier wave can then be sent to a power amplifier (“PA”) 1014 and can be transmitted via the transmitter receiver device 1006 via the diplexer 1016.Signals received from the transmitter/receiver device 1006 that are directed towards the communications interface 1008 can be separated from other signals via diplexer 1016.The received signal can then be sent to low noise amplifier (“LNA”) 1018 for amplification.", "A frequency mixer 1020, with help from local oscillator 1012 can downshift the received signal (which is in the millimeter-wave band or around 38 GHz in some embodiments) to the native frequency.", "The communications interface 1008 can then receive the transmission at an input port (Rx).", "In an embodiment, transmitter/receiver device 1006 can include a cylindrical or non-cylindrical metal (which, for example, can be hollow in an embodiment, but not necessarily drawn to scale) or other conducting or non-conducting waveguide and an end of the stub coupler 1002 can be placed in or in proximity to the waveguide or the transmitter/receiver device 1006 such that when the transmitter/receiver device 1006 generates a transmission, the guided wave couples to stub coupler 1002 and propagates as a guided wave 1004 about the waveguide surface of the stub coupler 1002.In some embodiments, the guided wave 1004 can propagate in part on the outer surface of the stub coupler 1002 and in part inside the stub coupler 1002.In other embodiments, the guided wave 1004 can propagate substantially or completely on the outer surface of the stub coupler 1002.In yet other embodiments, the guided wave 1004 can propagate substantially or completely inside the stub coupler 1002.In this latter embodiment, the guided wave 1004 can radiate at an end of the stub coupler 1002 (such as the tapered end shown in FIG.", "4) for coupling to a transmission medium such as a wire 702 of FIG.", "7.Similarly, if guided wave 1004 is incoming (coupled to the stub coupler 1002 from a wire 702), guided wave 1004 then enters the transmitter/receiver device 1006 and couples to the cylindrical waveguide or conducting waveguide.", "While transmitter/receiver device 1006 is shown to include a separate waveguide—an antenna, cavity resonator, klystron, magnetron, travelling wave tube, or other radiating element can be employed to induce a guided wave on the coupler 1002, with or without the separate waveguide.", "In an embodiment, stub coupler 1002 can be wholly constructed of a dielectric material (or another suitable insulating material), without any metallic or otherwise conducting materials therein.", "Stub coupler 1002 can be composed of nylon, Teflon, polyethylene, a polyamide, other plastics, or other materials that are non-conducting and suitable for facilitating transmission of electromagnetic waves at least in part on an outer surface of such materials.", "In another embodiment, stub coupler 1002 can include a core that is conducting/metallic, and have an exterior dielectric surface.", "Similarly, a transmission medium that couples to the stub coupler 1002 for propagating electromagnetic waves induced by the stub coupler 1002 or for supplying electromagnetic waves to the stub coupler 1002 can, in addition to being a bare or insulated wire, be wholly constructed of a dielectric material (or another suitable insulating material), without any metallic or otherwise conducting materials therein.", "It is noted that although FIG.", "10A shows that the opening of transmitter receiver device 1006 is much wider than the stub coupler 1002, this is not to scale, and that in other embodiments the width of the stub coupler 1002 is comparable or slightly smaller than the opening of the hollow waveguide.", "It is also not shown, but in an embodiment, an end of the coupler 1002 that is inserted into the transmitter/receiver device 1006 tapers down in order to reduce reflection and increase coupling efficiencies.", "Before coupling to the stub coupler 1002, the one or more waveguide modes of the guided wave generated by the transmitter/receiver device 1006 can couple to the stub coupler 1002 to induce one or more wave propagation modes of the guided wave 1004.The wave propagation modes of the guided wave 1004 can be different than the hollow metal waveguide modes due to the different characteristics of the hollow metal waveguide and the dielectric waveguide.", "For instance, wave propagation modes of the guided wave 1004 can comprise the fundamental transverse electromagnetic mode (Quasi-TEM00), where only small electrical and/or magnetic fields extend in the direction of propagation, and the electric and magnetic fields extend radially outwards from the stub coupler 1002 while the guided waves propagate along the stub coupler 1002.The fundamental transverse electromagnetic mode wave propagation mode may or may not exist inside a waveguide that is hollow.", "Therefore, the hollow metal waveguide modes that are used by transmitter/receiver device 1006 are waveguide modes that can couple effectively and efficiently to wave propagation modes of stub coupler 1002.It will be appreciated that other constructs or combinations of the transmitter/receiver device 1006 and stub coupler 1002 are possible.", "For example, a stub coupler 1002′ can be placed tangentially or in parallel (with or without a gap) with respect to an outer surface of the hollow metal waveguide of the transmitter/receiver device 1006′ (corresponding circuitry not shown) as depicted by reference 1000′ of FIG.", "10B.", "In another embodiment, not shown by reference 1000′, the stub coupler 1002′ can be placed inside the hollow metal waveguide of the transmitter/receiver device 1006′ without an axis of the stub coupler 1002′ being coaxially aligned with an axis of the hollow metal waveguide of the transmitter/receiver device 1006′.", "In either of these embodiments, the guided wave generated by the transmitter/receiver device 1006′ can couple to a surface of the stub coupler 1002′ to induce one or more wave propagation modes of the guided wave 1004′ on the stub coupler 1002′ including a fundamental mode (e.g., a symmetric mode) and/or a non-fundamental mode (e.g., asymmetric mode).", "In one embodiment, the guided wave 1004′ can propagate in part on the outer surface of the stub coupler 1002′ and in part inside the stub coupler 1002′.", "In another embodiment, the guided wave 1004′ can propagate substantially or completely on the outer surface of the stub coupler 1002′.", "In yet other embodiments, the guided wave 1004′ can propagate substantially or completely inside the stub coupler 1002′.", "In this latter embodiment, the guided wave 1004′ can radiate at an end of the stub coupler 1002′ (such as the tapered end shown in FIG.", "9) for coupling to a transmission medium such as a wire 702 of FIG.", "9.It will be further appreciated that other constructs the transmitter/receiver device 1006 are possible.", "For example, a hollow metal waveguide of a transmitter/receiver device 1006″ (corresponding circuitry not shown), depicted in FIG.", "10B as reference 1000″, can be placed tangentially or in parallel (with or without a gap) with respect to an outer surface of a transmission medium such as the wire 702 of FIG.", "4 without the use of the stub coupler 1002.In this embodiment, the guided wave generated by the transmitter/receiver device 1006″ can couple to a surface of the wire 702 to induce one or more wave propagation modes of a guided wave 908 on the wire 702 including a fundamental mode (e.g., a symmetric mode) and/or a non-fundamental mode (e.g., asymmetric mode).", "In another embodiment, the wire 702 can be positioned inside a hollow metal waveguide of a transmitter/receiver device 1006′ (corresponding circuitry not shown) so that an axis of the wire 702 is coaxially (or not coaxially) aligned with an axis of the hollow metal waveguide without the use of the stub coupler 1002—see FIGS.", "10B reference 1000″′.", "In this embodiment, the guided wave generated by the transmitter/receiver device 1006″′ can couple to a surface of the wire 702 to induce one or more wave propagation modes of a guided wave 908 on the wire including a fundamental mode (e.g., a symmetric mode) and/or a non-fundamental mode (e.g., asymmetric mode).", "In the embodiments of 1000″ and 1000″′, for a wire 702 having an insulated outer surface, the guided wave 908 can propagate in part on the outer surface of the insulator and in part inside the insulator.", "In embodiments, the guided wave 908 can propagate substantially or completely on the outer surface of the insulator, or substantially or completely inside the insulator.", "In the embodiments of 1000″ and 1000″′, for a wire 702 that is a bare conductor, the guided wave 908 can propagate in part on the outer surface of the conductor and in part inside the conductor.", "In another embodiment, the guided wave 908 can propagate substantially or completely on the outer surface of the conductor.", "Referring now to FIG.", "11, a block diagram 1100 illustrating an example, non-limiting embodiment of a dual stub coupler is shown.", "In particular, a dual coupler design is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.In an embodiment, two or more couplers (such as the stub couplers 1104 and 1106) can be positioned around a wire 1102 in order to receive guided wave 1108.In an embodiment, one coupler is enough to receive the guided wave 1108.In that case, guided wave 1108 couples to coupler 1104 and propagates as guided wave 1110.If the field structure of the guided wave 1108 oscillates or undulates around the wire 1102 due to the particular guided wave mode(s) or various outside factors, then coupler 1106 can be placed such that guided wave 1108 couples to coupler 1106.In some embodiments, four or more couplers can be placed around a portion of the wire 1102, e.g., at 90 degrees or another spacing with respect to each other, in order to receive guided waves that may oscillate or rotate around the wire 1102, that have been induced at different azimuthal orientations or that have non-fundamental or higher order modes that, for example, have lobes and/or nulls or other asymmetries that are orientation dependent.", "However, it will be appreciated that there may be less than or more than four couplers placed around a portion of the wire 1102 without departing from example embodiments.", "It should be noted that while couplers 1106 and 1104 are illustrated as stub couplers, any other of the coupler designs described herein including arc couplers, antenna or horn couplers, magnetic couplers, etc., could likewise be used.", "It will also be appreciated that while some example embodiments have presented a plurality of couplers around at least a portion of a wire 1102, this plurality of couplers can also be considered as part of a single coupler system having multiple coupler subcomponents.", "For example, two or more couplers can be manufactured as single system that can be installed around a wire in a single installation such that the couplers are either pre-positioned or adjustable relative to each other (either manually or automatically with a controllable mechanism such as a motor or other actuator) in accordance with the single system.", "Receivers coupled to couplers 1106 and 1104 can use diversity combining to combine signals received from both couplers 1106 and 1104 in order to maximize the signal quality.", "In other embodiments, if one or the other of the couplers 1104 and 1106 receive a transmission that is above a predetermined threshold, receivers can use selection diversity when deciding which signal to use.", "Further, while reception by a plurality of couplers 1106 and 1104 is illustrated, transmission by couplers 1106 and 1104 in the same configuration can likewise take place.", "In particular, a wide range of multi-input multi-output (MIMO) transmission and reception techniques can be employed for transmissions where a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1 includes multiple transceivers and multiple couplers.", "It is noted that the graphical representations of waves 1108 and 1110 are presented merely to illustrate the principles that guided wave 1108 induces or otherwise launches a wave 1110 on a coupler 1104.The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on the frequencies employed, the design of the coupler 1104, the dimensions and composition of the wire 1102, as well as its surface characteristics, its insulation if any, the electromagnetic properties of the surrounding environment, etc.", "Referring now to FIG.", "12, a block diagram 1200 illustrating an example, non-limiting embodiment of a repeater system is shown.", "In particular, a repeater device 1210 is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.In this system, two couplers 1204 and 1214 can be placed near a wire 1202 or other transmission medium such that guided waves 1205 propagating along the wire 1202 are extracted by coupler 1204 as wave 1206 (e.g.", "as a guided wave), and then are boosted or repeated by repeater device 1210 and launched as a wave 1216 (e.g.", "as a guided wave) onto coupler 1214.The wave 1216 can then be launched on the wire 1202 and continue to propagate along the wire 1202 as a guided wave 1217.In an embodiment, the repeater device 1210 can receive at least a portion of the power utilized for boosting or repeating through magnetic coupling with the wire 1202, for example, when the wire 1202 is a power line or otherwise contains a power-carrying conductor.", "It should be noted that while couplers 1204 and 1214 are illustrated as stub couplers, any other of the coupler designs described herein including arc couplers, antenna or horn couplers, magnetic couplers, or the like, could likewise be used.", "In some embodiments, repeater device 1210 can repeat the transmission associated with wave 1206, and in other embodiments, repeater device 1210 can include a communications interface 205 that extracts data or other signals from the wave 1206 for supplying such data or signals to another network and/or one or more other devices as communication signals 110 or 112 and/or receiving communication signals 110 or 112 from another network and/or one or more other devices and launch guided wave 1216 having embedded therein the received communication signals 110 or 112.In a repeater configuration, receiver waveguide 1208 can receive the wave 1206 from the coupler 1204 and transmitter waveguide 1212 can launch guided wave 1216 onto coupler 1214 as guided wave 1217.Between receiver waveguide 1208 and transmitter waveguide 1212, the signal embedded in guided wave 1206 and/or the guided wave 1216 itself can be amplified to correct for signal loss and other inefficiencies associated with guided wave communications or the signal can be received and processed to extract the data contained therein and regenerated for transmission.", "In an embodiment, the receiver waveguide 1208 can be configured to extract data from the signal, process the data to correct for data errors utilizing for example error correcting codes, and regenerate an updated signal with the corrected data.", "The transmitter waveguide 1212 can then transmit guided wave 1216 with the updated signal embedded therein.", "In an embodiment, a signal embedded in guided wave 1206 can be extracted from the transmission and processed for communication with another network and/or one or more other devices via communications interface 205 as communication signals 110 or 112.Similarly, communication signals 110 or 112 received by the communications interface 205 can be inserted into a transmission of guided wave 1216 that is generated and launched onto coupler 1214 by transmitter waveguide 1212.It is noted that although FIG.", "12 shows guided wave transmissions 1206 and 1216 entering from the left and exiting to the right respectively, this is merely a simplification and is not intended to be limiting.", "In other embodiments, receiver waveguide 1208 and transmitter waveguide 1212 can also function as transmitters and receivers respectively, allowing the repeater device 1210 to be bi-directional.", "In an embodiment, repeater device 1210 can be placed at locations where there are discontinuities or obstacles on the wire 1202 or other transmission medium.", "In the case where the wire 1202 is a power line, these obstacles can include transformers, connections, utility poles, and other such power line devices.", "The repeater device 1210 can help the guided (e.g., surface) waves jump over these obstacles on the line and boost the transmission power at the same time.", "In other embodiments, a coupler can be used to jump over the obstacle without the use of a repeater device.", "In that embodiment, both ends of the coupler can be tied or fastened to the wire, thus providing a path for the guided wave to travel without being blocked by the obstacle.", "Turning now to FIG.", "13, illustrated is a block diagram 1300 of an example, non-limiting embodiment of a bidirectional repeater in accordance with various aspects described herein.", "In particular, a bidirectional repeater device 1306 is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.It should be noted that while the couplers are illustrated as stub couplers, any other of the coupler designs described herein including arc couplers, antenna or horn couplers, magnetic couplers, or the like, could likewise be used.", "The bidirectional repeater 1306 can employ diversity paths in the case of when two or more wires or other transmission media are present.", "Since guided wave transmissions have different transmission efficiencies and coupling efficiencies for transmission medium of different types such as insulated wires, un-insulated wires or other types of transmission media and further, if exposed to the elements, can be affected by weather, and other atmospheric conditions, it can be advantageous to selectively transmit on different transmission media at certain times.", "In various embodiments, the various transmission media can be designated as a primary, secondary, tertiary, etc.", "whether or not such designation indicates a preference of one transmission medium over another.", "In the embodiment shown, the transmission media include an insulated or uninsulated wire 1302 and an insulated or uninsulated wire 1304 (referred to herein as wires 1302 and 1304, respectively).", "The repeater device 1306 uses a receiver coupler 1308 to receive a guided wave traveling along wire 1302 and repeats the transmission using transmitter waveguide 1310 as a guided wave along wire 1304.In other embodiments, repeater device 1306 can switch from the wire 1304 to the wire 1302, or can repeat the transmissions along the same paths.", "Repeater device 1306 can include sensors, or be in communication with sensors (or a network management system 1601 depicted in FIG.", "16A) that indicate conditions that can affect the transmission.", "Based on the feedback received from the sensors, the repeater device 1306 can make the determination about whether to keep the transmission along the same wire, or transfer the transmission to the other wire.", "Turning now to FIG.", "14, illustrated is a block diagram 1400 illustrating an example, non-limiting embodiment of a bidirectional repeater system.", "In particular, a bidirectional repeater system is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.The bidirectional repeater system includes waveguide coupling devices 1402 and 1404 that receive and transmit transmissions from other coupling devices located in a distributed antenna system or backhaul system.", "In various embodiments, waveguide coupling device 1402 can receive a transmission from another waveguide coupling device, wherein the transmission has a plurality of subcarriers.", "Diplexer 1406 can separate the transmission from other transmissions, and direct the transmission to low-noise amplifier (“LNA”) 1408.A frequency mixer 1428, with help from a local oscillator 1412, can downshift the transmission (which is in the millimeter-wave band or around 38 GHz in some embodiments) to a lower frequency, such as a cellular band (˜1.9 GHz) for a distributed antenna system, a native frequency, or other frequency for a backhaul system.", "An extractor (or demultiplexer) 1432 can extract the signal on a subcarrier and direct the signal to an output component 1422 for optional amplification, buffering or isolation by power amplifier 1424 for coupling to communications interface 205.The communications interface 205 can further process the signals received from the power amplifier 1424 or otherwise transmit such signals over a wireless or wired interface to other devices such as a base station, mobile devices, a building, etc.", "For the signals that are not being extracted at this location, extractor 1432 can redirect them to another frequency mixer 1436, where the signals are used to modulate a carrier wave generated by local oscillator 1414.The carrier wave, with its subcarriers, is directed to a power amplifier (“PA”) 1416 and is retransmitted by waveguide coupling device 1404 to another system, via diplexer 1420.An LNA 1426 can be used to amplify, buffer or isolate signals that are received by the communication interface 205 and then send the signal to a multiplexer 1434 which merges the signal with signals that have been received from waveguide coupling device 1404.The signals received from coupling device 1404 have been split by diplexer 1420, and then passed through LNA 1418, and downshifted in frequency by frequency mixer 1438.When the signals are combined by multiplexer 1434, they are upshifted in frequency by frequency mixer 1430, and then boosted by PA 1410, and transmitted to another system by waveguide coupling device 1402.In an embodiment bidirectional repeater system can be merely a repeater without the output device 1422.In this embodiment, the multiplexer 1434 would not be utilized and signals from LNA 1418 would be directed to mixer 1430 as previously described.", "It will be appreciated that in some embodiments, the bidirectional repeater system could also be implemented using two distinct and separate unidirectional repeaters.", "In an alternative embodiment, a bidirectional repeater system could also be a booster or otherwise perform retransmissions without downshifting and upshifting.", "Indeed in example embodiment, the retransmissions can be based upon receiving a signal or guided wave and performing some signal or guided wave processing or reshaping, filtering, and/or amplification, prior to retransmission of the signal or guided wave.", "Referring now to FIG.", "15, a block diagram 1500 illustrating an example, non-limiting embodiment of a guided wave communications system is shown.", "This diagram depicts an exemplary environment in which a guided wave communication system, such as the guided wave communication system presented in conjunction with FIG.", "1, can be used.", "To provide network connectivity to additional base station devices, a backhaul network that links the communication cells (e.g., macrocells and macrocells) to network devices of a core network correspondingly expands.", "Similarly, to provide network connectivity to a distributed antenna system, an extended communication system that links base station devices and their distributed antennas is desirable.", "A guided wave communication system 1500 such as shown in FIG.", "15 can be provided to enable alternative, increased or additional network connectivity and a waveguide coupling system can be provided to transmit and/or receive guided wave (e.g., surface wave) communications on a transmission medium such as a wire that operates as a single-wire transmission line (e.g., a utility line), and that can be used as a waveguide and/or that otherwise operates to guide the transmission of an electromagnetic wave.", "The guided wave communication system 1500 can comprise a first instance of a distribution system 1550 that includes one or more base station devices (e.g., base station device 1504) that are communicably coupled to a central office 1501 and/or a macrocell site 1502.Base station device 1504 can be connected by a wired (e.g., fiber and/or cable), or by a wireless (e.g., microwave wireless) connection to the macrocell site 1502 and the central office 1501.A second instance of the distribution system 1560 can be used to provide wireless voice and data services to mobile device 1522 and to residential and/or commercial establishments 1542 (herein referred to as establishments 1542).", "System 1500 can have additional instances of the distribution systems 1550 and 1560 for providing voice and/or data services to mobile devices 1522-1524 and establishments 1542 as shown in FIG.", "15.Macrocells such as macrocell site 1502 can have dedicated connections to a mobile network and base station device 1504 or can share and/or otherwise use another connection.", "Central office 1501 can be used to distribute media content and/or provide internet service provider (ISP) services to mobile devices 1522-1524 and establishments 1542.The central office 1501 can receive media content from a constellation of satellites 1530 (one of which is shown in FIG.", "15) or other sources of content, and distribute such content to mobile devices 1522-1524 and establishments 1542 via the first and second instances of the distribution system 1550 and 1560.The central office 1501 can also be communicatively coupled to the Internet 1503 for providing internet data services to mobile devices 1522-1524 and establishments 1542.Base station device 1504 can be mounted on, or attached to, utility pole 1516.In other embodiments, base station device 1504 can be near transformers and/or other locations situated nearby a power line.", "Base station device 1504 can facilitate connectivity to a mobile network for mobile devices 1522 and 1524.Antennas 1512 and 1514, mounted on or near utility poles 1518 and 1520, respectively, can receive signals from base station device 1504 and transmit those signals to mobile devices 1522 and 1524 over a much wider area than if the antennas 1512 and 1514 were located at or near base station device 1504.It is noted that FIG.", "15 displays three utility poles, in each instance of the distribution systems 1550 and 1560, with one base station device, for purposes of simplicity.", "In other embodiments, utility pole 1516 can have more base station devices, and more utility poles with distributed antennas and/or tethered connections to establishments 1542.A transmission device 1506, such as transmission device 101 or 102 presented in conjunction with FIG.", "1, can transmit a signal from base station device 1504 to antennas 1512 and 1514 via utility or power line(s) that connect the utility poles 1516, 1518, and 1520.To transmit the signal, radio source and/or transmission device 1506 upconverts the signal (e.g., via frequency mixing) from base station device 1504 or otherwise converts the signal from the base station device 1504 to a microwave band signal and the transmission device 1506 launches a microwave band wave that propagates as a guided wave traveling along the utility line or other wire as described in previous embodiments.", "At utility pole 1518, another transmission device 1508 receives the guided wave (and optionally can amplify it as needed or desired or operate as a repeater to receive it and regenerate it) and sends it forward as a guided wave on the utility line or other wire.", "The transmission device 1508 can also extract a signal from the microwave band guided wave and shift it down in frequency or otherwise convert it to its original cellular band frequency (e.g., 1.9 GHz or other defined cellular frequency) or another cellular (or non-cellular) band frequency.", "An antenna 1512 can wireless transmit the downshifted signal to mobile device 1522.The process can be repeated by transmission device 1510, antenna 1514 and mobile device 1524, as necessary or desirable.", "Transmissions from mobile devices 1522 and 1524 can also be received by antennas 1512 and 1514 respectively.", "The transmission devices 1508 and 1510 can upshift or otherwise convert the cellular band signals to microwave band and transmit the signals as guided wave (e.g., surface wave or other electromagnetic wave) transmissions over the power line(s) to base station device 1504.Media content received by the central office 1501 can be supplied to the second instance of the distribution system 1560 via the base station device 1504 for distribution to mobile devices 1522 and establishments 1542.The transmission device 1510 can be tethered to the establishments 1542 by one or more wired connections or a wireless interface.", "The one or more wired connections may include without limitation, a power line, a coaxial cable, a fiber cable, a twisted pair cable, a guided wave transmission medium or other suitable wired mediums for distribution of media content and/or for providing internet services.", "In an example embodiment, the wired connections from the transmission device 1510 can be communicatively coupled to one or more very high bit rate digital subscriber line (VDSL) modems located at one or more corresponding service area interfaces (SAIs—not shown) or pedestals, each SAI or pedestal providing services to a portion of the establishments 1542.The VDSL modems can be used to selectively distribute media content and/or provide internet services to gateways (not shown) located in the establishments 1542.The SAIs or pedestals can also be communicatively coupled to the establishments 1542 over a wired medium such as a power line, a coaxial cable, a fiber cable, a twisted pair cable, a guided wave transmission medium or other suitable wired mediums.", "In other example embodiments, the transmission device 1510 can be communicatively coupled directly to establishments 1542 without intermediate interfaces such as the SAIs or pedestals.", "In another example embodiment, system 1500 can employ diversity paths, where two or more utility lines or other wires are strung between the utility poles 1516, 1518, and 1520 (e.g., for example, two or more wires between poles 1516 and 1520) and redundant transmissions from base station/macrocell site 1502 are transmitted as guided waves down the surface of the utility lines or other wires.", "The utility lines or other wires can be either insulated or uninsulated, and depending on the environmental conditions that cause transmission losses, the coupling devices can selectively receive signals from the insulated or uninsulated utility lines or other wires.", "The selection can be based on measurements of the signal-to-noise ratio of the wires, or based on determined weather/environmental conditions (e.g., moisture detectors, weather forecasts, etc.).", "The use of diversity paths with system 1500 can enable alternate routing capabilities, load balancing, increased load handling, concurrent bi-directional or synchronous communications, spread spectrum communications, etc.", "It is noted that the use of the transmission devices 1506, 1508, and 1510 in FIG.", "15 are by way of example only, and that in other embodiments, other uses are possible.", "For instance, transmission devices can be used in a backhaul communication system, providing network connectivity to base station devices.", "Transmission devices 1506, 1508, and 1510 can be used in many circumstances where it is desirable to transmit guided wave communications over a wire, whether insulated or not insulated.", "Transmission devices 1506, 1508, and 1510 are improvements over other coupling devices due to no contact or limited physical and/or electrical contact with the wires that may carry high voltages.", "The transmission device can be located away from the wire (e.g., spaced apart from the wire) and/or located on the wire so long as it is not electrically in contact with the wire, as the dielectric acts as an insulator, allowing for cheap, easy, and/or less complex installation.", "However, as previously noted conducting or non-dielectric couplers can be employed, for example in configurations where the wires correspond to a telephone network, cable television network, broadband data service, fiber optic communications system or other network employing low voltages or having insulated transmission lines.", "It is further noted, that while base station device 1504 and macrocell site 1502 are illustrated in an embodiment, other network configurations are likewise possible.", "For example, devices such as access points or other wireless gateways can be employed in a similar fashion to extend the reach of other networks such as a wireless local area network, a wireless personal area network or other wireless network that operates in accordance with a communication protocol such as a 802.11 protocol, WIMAX protocol, Ultra-Wideband protocol, Bluetooth protocol, ZigBee protocol or other wireless protocol.", "Referring now to FIGS.", "16A, 16B and 16C, block diagrams illustrating an example, non-limiting embodiment of a system for managing a communication system are shown.", "Considering FIG.", "16A, a waveguide system 1602 is presented for use in a guided wave communications system, such as the system presented in conjunction with FIG.", "15.The waveguide system 1602 can comprise sensors 1604, a power management system 1605, a transmission device 101 or 102 that includes at least one communication interface 205, transceiver 210 and coupler 220.The waveguide system 1602 can be coupled to a power line 1610 for facilitating guided wave communications in accordance with embodiments described in the subject disclosure.", "In an example embodiment, the transmission device 101 or 102 includes coupler 220 for inducing electromagnetic waves on a surface of the power line 1610 that longitudinally propagate along the surface of the power line 1610 as described in the subject disclosure.", "The transmission device 101 or 102 can also serve as a repeater for retransmitting electromagnetic waves on the same power line 1610 or for routing electromagnetic waves between power lines 1610 as shown in FIGS.", "12-13.The transmission device 101 or 102 includes transceiver 210 configured to, for example, up-convert a signal operating at an original frequency range to electromagnetic waves operating at, exhibiting, or associated with a carrier frequency that propagate along a coupler to induce corresponding guided electromagnetic waves that propagate along a surface of the power line 1610.A carrier frequency can be represented by a center frequency having upper and lower cutoff frequencies that define the bandwidth of the electromagnetic waves.", "The power line 1610 can be a wire (e.g., single stranded or multi-stranded) having a conducting surface or insulated surface.", "The transceiver 210 can also receive signals from the coupler 220 and down-convert the electromagnetic waves operating at a carrier frequency to signals at their original frequency.", "Signals received by the communications interface 205 of transmission device 101 or 102 for up-conversion can include without limitation signals supplied by a central office 1611 over a wired or wireless interface of the communications interface 205, a base station 1614 over a wired or wireless interface of the communications interface 205, wireless signals transmitted by mobile devices 1620 to the base station 1614 for delivery over the wired or wireless interface of the communications interface 205, signals supplied by in-building communication devices 1618 over the wired or wireless interface of the communications interface 205, and/or wireless signals supplied to the communications interface 205 by mobile devices 1612 roaming in a wireless communication range of the communications interface 205.In embodiments where the waveguide system 1602 functions as a repeater, such as shown in FIGS.", "12-13, the communications interface 205 may or may not be included in the waveguide system 1602.The electromagnetic waves propagating along the surface of the power line 1610 can be modulated and formatted to include packets or frames of data that include a data payload and further include networking information (such as header information for identifying one or more destination waveguide systems 1602).", "The networking information may be provided by the waveguide system 1602 or an originating device such as the central office 1611, the base station 1614, mobile devices 1620, or in-building devices 1618, or a combination thereof.", "Additionally, the modulated electromagnetic waves can include error correction data for mitigating signal disturbances.", "The networking information and error correction data can be used by a destination waveguide system 1602 for detecting transmissions directed to it, and for down-converting and processing with error correction data transmissions that include voice and/or data signals directed to recipient communication devices communicatively coupled to the destination waveguide system 1602.Referring now to the sensors 1604 of the waveguide system 1602, the sensors 1604 can comprise one or more of a temperature sensor 1604a, a disturbance detection sensor 1604b, a loss of energy sensor 1604c, a noise sensor 1604d, a vibration sensor 1604e, an environmental (e.g., weather) sensor 1604f, and/or an image sensor 1604g.", "The temperature sensor 1604a can be used to measure ambient temperature, a temperature of the transmission device 101 or 102, a temperature of the power line 1610, temperature differentials (e.g., compared to a setpoint or baseline, between transmission device 101 or 102 and 1610, etc.", "), or any combination thereof.", "In one embodiment, temperature metrics can be collected and reported periodically to a network management system 1601 by way of the base station 1614.The disturbance detection sensor 1604b can perform measurements on the power line 1610 to detect disturbances such as signal reflections, which may indicate a presence of a downstream disturbance that may impede the propagation of electromagnetic waves on the power line 1610.A signal reflection can represent a distortion resulting from, for example, an electromagnetic wave transmitted on the power line 1610 by the transmission device 101 or 102 that reflects in whole or in part back to the transmission device 101 or 102 from a disturbance in the power line 1610 located downstream from the transmission device 101 or 102.Signal reflections can be caused by obstructions on the power line 1610.For example, a tree limb may cause electromagnetic wave reflections when the tree limb is lying on the power line 1610, or is in close proximity to the power line 1610 which may cause a corona discharge.", "Other obstructions that can cause electromagnetic wave reflections can include without limitation an object that has been entangled on the power line 1610 (e.g., clothing, a shoe wrapped around a power line 1610 with a shoe string, etc.", "), a corroded build-up on the power line 1610 or an ice build-up.", "Power grid components may also impede or obstruct with the propagation of electromagnetic waves on the surface of power lines 1610.Illustrations of power grid components that may cause signal reflections include without limitation a transformer and a joint for connecting spliced power lines.", "A sharp angle on the power line 1610 may also cause electromagnetic wave reflections.", "The disturbance detection sensor 1604b can comprise a circuit to compare magnitudes of electromagnetic wave reflections to magnitudes of original electromagnetic waves transmitted by the transmission device 101 or 102 to determine how much a downstream disturbance in the power line 1610 attenuates transmissions.", "The disturbance detection sensor 1604b can further comprise a spectral analyzer circuit for performing spectral analysis on the reflected waves.", "The spectral data generated by the spectral analyzer circuit can be compared with spectral profiles via pattern recognition, an expert system, curve fitting, matched filtering or other artificial intelligence, classification or comparison technique to identify a type of disturbance based on, for example, the spectral profile that most closely matches the spectral data.", "The spectral profiles can be stored in a memory of the disturbance detection sensor 1604b or may be remotely accessible by the disturbance detection sensor 1604b.", "The profiles can comprise spectral data that models different disturbances that may be encountered on power lines 1610 to enable the disturbance detection sensor 1604b to identify disturbances locally.", "An identification of the disturbance if known can be reported to the network management system 1601 by way of the base station 1614.The disturbance detection sensor 1604b can also utilize the transmission device 101 or 102 to transmit electromagnetic waves as test signals to determine a roundtrip time for an electromagnetic wave reflection.", "The round trip time measured by the disturbance detection sensor 1604b can be used to calculate a distance traveled by the electromagnetic wave up to a point where the reflection takes place, which enables the disturbance detection sensor 1604b to calculate a distance from the transmission device 101 or 102 to the downstream disturbance on the power line 1610.The distance calculated can be reported to the network management system 1601 by way of the base station 1614.In one embodiment, the location of the waveguide system 1602 on the power line 1610 may be known to the network management system 1601, which the network management system 1601 can use to determine a location of the disturbance on the power line 1610 based on a known topology of the power grid.", "In another embodiment, the waveguide system 1602 can provide its location to the network management system 1601 to assist in the determination of the location of the disturbance on the power line 1610.The location of the waveguide system 1602 can be obtained by the waveguide system 1602 from a pre-programmed location of the waveguide system 1602 stored in a memory of the waveguide system 1602, or the waveguide system 1602 can determine its location using a GPS receiver (not shown) included in the waveguide system 1602.The power management system 1605 provides energy to the aforementioned components of the waveguide system 1602.The power management system 1605 can receive energy from solar cells, or from a transformer (not shown) coupled to the power line 1610, or by inductive coupling to the power line 1610 or another nearby power line.", "The power management system 1605 can also include a backup battery and/or a super capacitor or other capacitor circuit for providing the waveguide system 1602 with temporary power.", "The loss of energy sensor 1604c can be used to detect when the waveguide system 1602 has a loss of power condition and/or the occurrence of some other malfunction.", "For example, the loss of energy sensor 1604c can detect when there is a loss of power due to defective solar cells, an obstruction on the solar cells that causes them to malfunction, loss of power on the power line 1610, and/or when the backup power system malfunctions due to expiration of a backup battery, or a detectable defect in a super capacitor.", "When a malfunction and/or loss of power occurs, the loss of energy sensor 1604c can notify the network management system 1601 by way of the base station 1614.The noise sensor 1604d can be used to measure noise on the power line 1610 that may adversely affect transmission of electromagnetic waves on the power line 1610.The noise sensor 1604d can sense unexpected electromagnetic interference, noise bursts, or other sources of disturbances that may interrupt reception of modulated electromagnetic waves on a surface of a power line 1610.A noise burst can be caused by, for example, a corona discharge, or other source of noise.", "The noise sensor 1604d can compare the measured noise to a noise profile obtained by the waveguide system 1602 from an internal database of noise profiles or from a remotely located database that stores noise profiles via pattern recognition, an expert system, curve fitting, matched filtering or other artificial intelligence, classification or comparison technique.", "From the comparison, the noise sensor 1604d may identify a noise source (e.g., corona discharge or otherwise) based on, for example, the noise profile that provides the closest match to the measured noise.", "The noise sensor 1604d can also detect how noise affects transmissions by measuring transmission metrics such as bit error rate, packet loss rate, jitter, packet retransmission requests, etc.", "The noise sensor 1604d can report to the network management system 1601 by way of the base station 1614 the identity of noise sources, their time of occurrence, and transmission metrics, among other things.", "The vibration sensor 1604e can include accelerometers and/or gyroscopes to detect 2D or 3D vibrations on the power line 1610.The vibrations can be compared to vibration profiles that can be stored locally in the waveguide system 1602, or obtained by the waveguide system 1602 from a remote database via pattern recognition, an expert system, curve fitting, matched filtering or other artificial intelligence, classification or comparison technique.", "Vibration profiles can be used, for example, to distinguish fallen trees from wind gusts based on, for example, the vibration profile that provides the closest match to the measured vibrations.", "The results of this analysis can be reported by the vibration sensor 1604e to the network management system 1601 by way of the base station 1614.The environmental sensor 1604f can include a barometer for measuring atmospheric pressure, ambient temperature (which can be provided by the temperature sensor 1604a), wind speed, humidity, wind direction, and rainfall, among other things.", "The environmental sensor 1604f can collect raw information and process this information by comparing it to environmental profiles that can be obtained from a memory of the waveguide system 1602 or a remote database to predict weather conditions before they arise via pattern recognition, an expert system, knowledge-based system or other artificial intelligence, classification or other weather modeling and prediction technique.", "The environmental sensor 1604f can report raw data as well as its analysis to the network management system 1601.The image sensor 1604g can be a digital camera (e.g., a charged coupled device or CCD imager, infrared camera, etc.)", "for capturing images in a vicinity of the waveguide system 1602.The image sensor 1604g can include an electromechanical mechanism to control movement (e.g., actual position or focal points/zooms) of the camera for inspecting the power line 1610 from multiple perspectives (e.g., top surface, bottom surface, left surface, right surface and so on).", "Alternatively, the image sensor 1604g can be designed such that no electromechanical mechanism is needed in order to obtain the multiple perspectives.", "The collection and retrieval of imaging data generated by the image sensor 1604g can be controlled by the network management system 1601, or can be autonomously collected and reported by the image sensor 1604g to the network management system 1601.Other sensors that may be suitable for collecting telemetry information associated with the waveguide system 1602 and/or the power lines 1610 for purposes of detecting, predicting and/or mitigating disturbances that can impede the propagation of electromagnetic wave transmissions on power lines 1610 (or any other form of a transmission medium of electromagnetic waves) may be utilized by the waveguide system 1602.To mitigate harsh winter conditions, the waveguide system 1602 of FIG.", "16A can be adapted to use a heater system 1630 such as depicted in FIG.", "16B.", "The heater system 1630 can comprise a toroidal inductor 1631 that surrounds a cross-sectional view of a transmission medium 1633, such as the power line 1610 shown in FIG.", "16A.", "The toroidal inductor 1631 can be constructed of multiple turns of wire 1636 wrapped around an annular toroid of powdered iron or other ferrite (referred to herein, for illustration purposes, as a ferrite core 1637).", "In an embodiment where the transmission medium 1633 is a bare wire, a dielectric washer or other insulator 1635 can provide electrical insulation while supporting the wire within the toroidal inductor 1631.Such a dielectric washer can be constructed of Teflon, polystyrene, polyethylene or other dielectric or insulating material.", "In cases where the transmission medium 1633 is nonconductive or includes an insulating sheath or jacket, the dielectric washer can be eliminated.", "A power signal conducted by the transmission medium 1633 (e.g., 60 Hz or 50 Hz medium voltage power signal) can induce currents in the wire 1636 wrapped around the ferrite core 1637.The current induced in the wire 1636 can feed a heating element (e.g., a resistor) 1632.To control activation of the heating element 1632, the heating element 1632 can include a controllable switch (not shown) that can be opened to break the circuit formed by the wire 1636 and the heating element 1632, and thereby disable the heating element 1632.When the switch is closed and current begins to flow in the circuit, the heating element 1632 is enabled and thereby emits heat.", "In one embodiment, the waveguide system 1602 of FIG.", "16A can utilize the temperature sensor 1604a to measure an internal temperature of the waveguide system 1602 and/or an ambient temperature in a vicinity of the waveguide system 1602.In an embodiment, the waveguide system 1602 can use the image sensor 1604g singly or in combination with the temperature sensor 1604a.", "The image sensor 1604g can be used to determine if ice and/or snow is accumulating on an outer surface of the waveguide system 1602.To place the toroidal inductor 1631 on a transmission medium 1633, such as a power line, the toroidal inductor 1631 can be inserted into the transmission medium 1633 through a middle cavity opening of the toroidal inductor 1631 if the power line has an open endpoint, or can be separated mechanically at the dashed lines 1639.In the latter embodiment, the toroidal inductor 1631 can be separated to enable placement on the transmission medium 1633 and reattached with a hinge, latch or other mechanical features during an installation process of the waveguide system 1602 on the power line.", "Turning now to FIG.", "16D, flow diagram of an example, non-limiting embodiment of a method 1670 in accordance with various aspects described herein is shown.", "Method 1670 can begin with step 1672 where the waveguide system 1602 monitors the environment using the temperature sensor 1604a and/or the image sensor 1604g as described above.", "It the waveguide system 1602 determines at step 1674 that the measured temperature (internal and/or ambient) falls below one or more thresholds (e.g., 32° F.) and/or images indicate there is an accumulation of ice and/or snow on a housing assembly of the waveguide system 1602, a circuit 1634 shown in FIG.", "16B can generate at step 1676 a signal that causes the switch used by the heating element 1632 to close and thereby cause current to flow through the heating element 1632 to emit heat inside the waveguide system 1602.The circuit 1634 can be a controller (e.g., a microprocessor) of the waveguide system 1602.The heat emitted inside the housing assembly of the waveguide system 1602 can be used to prevent malfunction of circuits used by the waveguide system 1602 due to severe weather conditions.", "Additionally, the heat emitted by the heating element 1632 may radiate sufficiently to heat the housing assembly of the waveguide system 1602 and thereby cause snow or ice to melt.", "Once the waveguide system 1602 detects at steps 1672 that the temperature and/or snow or ice accumulation has dissipated, the waveguide system 1602 can proceed to step 1678 to disable the heating element 1632 by the circuit 1634 emitting a signal that causes the switch to open and break the circuit to prevent current flow in the heating element 1632.To maintain a steady temperature that prevents ice and/or snow accumulation, the steps of method 1670 can be adapted to operate as a thermostat that maintains a near constant temperature of the waveguide system 1602 to preemptively prevent snow and/or ice accumulation on the housing assembly of the waveguide system 1602.While for purposes of simplicity of explanation, the respective processes are shown and described as a series of blocks in FIG.", "16D, it is to be understood and appreciated that the claimed subject matter is not limited by the order of the blocks, as some blocks may occur in different orders and/or concurrently with other blocks from what is depicted and described herein.", "Moreover, not all illustrated blocks may be required to implement the methods described herein.", "Referring now to FIG.", "16C, block diagram 1650 illustrates an example, non-limiting embodiment of a system for managing a power grid 1653 and a communication system 1655 embedded therein or associated therewith in accordance with various aspects described herein.", "The communication system 1655 comprises a plurality of waveguide systems 1602 coupled to power lines 1610 of the power grid 1653.At least a portion of the waveguide systems 1602 used in the communication system 1655 can be in direct communication with a base station 1614 and/or the network management system 1601.Waveguide systems 1602 not directly connected to a base station 1614 or the network management system 1601 can engage in communication sessions with either a base station 1614 or the network management system 1601 by way of other downstream waveguide systems 1602 connected to a base station 1614 or the network management system 1601.The network management system 1601 can be communicatively coupled to equipment of a utility company 1652 and equipment of a communications service provider 1654 for providing each entity, status information associated with the power grid 1653 and the communication system 1655, respectively.", "The network management system 1601, the equipment of the utility company 1652, and the communications service provider 1654 can access communication devices utilized by utility company personnel 1656 and/or communication devices utilized by communications service provider personnel 1658 for purposes of providing status information and/or for directing such personnel in the management of the power grid 1653 and/or communication system 1655.FIG.", "17A illustrates a flow diagram of an example, non-limiting embodiment of a method 1700 for detecting and mitigating disturbances occurring in a communication network of the systems of FIGS.", "16A-16C.", "Method 1700 can begin with step 1702 where a waveguide system 1602 transmits and receives messages embedded in, or forming part of, modulated electromagnetic waves or another type of electromagnetic waves traveling along a surface of a power line 1610.The messages can be voice messages, streaming video, and/or other data/information exchanged between communication devices communicatively coupled to the communication system 1655.At step 1704 the sensors 1604 of the waveguide system 1602 can collect sensing data.", "In an embodiment, the sensing data can be collected in step 1704 prior to, during, or after the transmission and/or receipt of messages in step 1702.At step 1706 the waveguide system 1602 (or the sensors 1604 themselves) can determine from the sensing data an actual or predicted occurrence of a disturbance in the communication system 1655 that can affect communications originating from (e.g., transmitted by) or received by the waveguide system 1602.The waveguide system 1602 (or the sensors 1604) can process temperature data, signal reflection data, loss of energy data, noise data, vibration data, environmental data, or any combination thereof to make this determination.", "The waveguide system 1602 (or the sensors 1604) may also detect, identify, estimate, or predict the source of the disturbance and/or its location in the communication system 1655.If a disturbance is neither detected/identified nor predicted/estimated at step 1708, the waveguide system 1602 can proceed to step 1702 where it continues to transmit and receive messages embedded in, or forming part of, modulated electromagnetic waves traveling along a surface of the power line 1610.If at step 1708 a disturbance is detected/identified or predicted/estimated to occur, the waveguide system 1602 proceeds to step 1710 to determine if the disturbance adversely affects (or alternatively, is likely to adversely affect or the extent to which it may adversely affect) transmission or reception of messages in the communication system 1655.In one embodiment, a duration threshold and a frequency of occurrence threshold can be used at step 1710 to determine when a disturbance adversely affects communications in the communication system 1655.For illustration purposes only, assume a duration threshold is set to 500 ms, while a frequency of occurrence threshold is set to 5 disturbances occurring in an observation period of 10 sec.", "Thus, a disturbance having a duration greater than 500 ms will trigger the duration threshold.", "Additionally, any disturbance occurring more than 5 times in a 10 sec time interval will trigger the frequency of occurrence threshold.", "In one embodiment, a disturbance may be considered to adversely affect signal integrity in the communication systems 1655 when the duration threshold alone is exceeded.", "In another embodiment, a disturbance may be considered as adversely affecting signal integrity in the communication systems 1655 when both the duration threshold and the frequency of occurrence threshold are exceeded.", "The latter embodiment is thus more conservative than the former embodiment for classifying disturbances that adversely affect signal integrity in the communication system 1655.It will be appreciated that many other algorithms and associated parameters and thresholds can be utilized for step 1710 in accordance with example embodiments.", "Referring back to method 1700, if at step 1710 the disturbance detected at step 1708 does not meet the condition for adversely affected communications (e.g., neither exceeds the duration threshold nor the frequency of occurrence threshold), the waveguide system 1602 may proceed to step 1702 and continue processing messages.", "For instance, if the disturbance detected in step 1708 has a duration of 1 ms with a single occurrence in a 10 sec time period, then neither threshold will be exceeded.", "Consequently, such a disturbance may be considered as having a nominal effect on signal integrity in the communication system 1655 and thus would not be flagged as a disturbance requiring mitigation.", "Although not flagged, the occurrence of the disturbance, its time of occurrence, its frequency of occurrence, spectral data, and/or other useful information, may be reported to the network management system 1601 as telemetry data for monitoring purposes.", "Referring back to step 1710, if on the other hand the disturbance satisfies the condition for adversely affected communications (e.g., exceeds either or both thresholds), the waveguide system 1602 can proceed to step 1712 and report the incident to the network management system 1601.The report can include raw sensing data collected by the sensors 1604, a description of the disturbance if known by the waveguide system 1602, a time of occurrence of the disturbance, a frequency of occurrence of the disturbance, a location associated with the disturbance, parameters readings such as bit error rate, packet loss rate, retransmission requests, jitter, latency and so on.", "If the disturbance is based on a prediction by one or more sensors of the waveguide system 1602, the report can include a type of disturbance expected, and if predictable, an expected time occurrence of the disturbance, and an expected frequency of occurrence of the predicted disturbance when the prediction is based on historical sensing data collected by the sensors 1604 of the waveguide system 1602.At step 1714, the network management system 1601 can determine a mitigation, circumvention, or correction technique, which may include directing the waveguide system 1602 to reroute traffic to circumvent the disturbance if the location of the disturbance can be determined.", "In one embodiment, the waveguide coupling device 1402 detecting the disturbance may direct a repeater such as the one shown in FIGS.", "13-14 to connect the waveguide system 1602 from a primary power line affected by the disturbance to a secondary power line to enable the waveguide system 1602 to reroute traffic to a different transmission medium and avoid the disturbance.", "In an embodiment where the waveguide system 1602 is configured as a repeater the waveguide system 1602 can itself perform the rerouting of traffic from the primary power line to the secondary power line.", "It is further noted that for bidirectional communications (e.g., full or half-duplex communications), the repeater can be configured to reroute traffic from the secondary power line back to the primary power line for processing by the waveguide system 1602.In another embodiment, the waveguide system 1602 can redirect traffic by instructing a first repeater situated upstream of the disturbance and a second repeater situated downstream of the disturbance to redirect traffic from a primary power line temporarily to a secondary power line and back to the primary power line in a manner that avoids the disturbance.", "It is further noted that for bidirectional communications (e.g., full or half-duplex communications), repeaters can be configured to reroute traffic from the secondary power line back to the primary power line.", "To avoid interrupting existing communication sessions occurring on a secondary power line, the network management system 1601 may direct the waveguide system 1602 to instruct repeater(s) to utilize unused time slot(s) and/or frequency band(s) of the secondary power line for redirecting data and/or voice traffic away from the primary power line to circumvent the disturbance.", "At step 1716, while traffic is being rerouted to avoid the disturbance, the network management system 1601 can notify equipment of the utility company 1652 and/or equipment of the communications service provider 1654, which in turn may notify personnel of the utility company 1656 and/or personnel of the communications service provider 1658 of the detected disturbance and its location if known.", "Field personnel from either party can attend to resolving the disturbance at a determined location of the disturbance.", "Once the disturbance is removed or otherwise mitigated by personnel of the utility company and/or personnel of the communications service provider, such personnel can notify their respective companies and/or the network management system 1601 utilizing field equipment (e.g., a laptop computer, smartphone, etc.)", "communicatively coupled to network management system 1601, and/or equipment of the utility company and/or the communications service provider.", "The notification can include a description of how the disturbance was mitigated and any changes to the power lines 1610 that may change a topology of the communication system 1655.Once the disturbance has been resolved (as determined in decision 1718), the network management system 1601 can direct the waveguide system 1602 at step 1720 to restore the previous routing configuration used by the waveguide system 1602 or route traffic according to a new routing configuration if the restoration strategy used to mitigate the disturbance resulted in a new network topology of the communication system 1655.In another embodiment, the waveguide system 1602 can be configured to monitor mitigation of the disturbance by transmitting test signals on the power line 1610 to determine when the disturbance has been removed.", "Once the waveguide system 1602 detects an absence of the disturbance it can autonomously restore its routing configuration without assistance by the network management system 1601 if it determines the network topology of the communication system 1655 has not changed, or it can utilize a new routing configuration that adapts to a detected new network topology.", "FIG.", "17B illustrates a flow diagram of an example, non-limiting embodiment of a method 1750 for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A-16C.", "In one embodiment, method 1750 can begin with step 1752 where a network management system 1601 receives from equipment of the utility company 1652 or equipment of the communications service provider 1654 maintenance information associated with a maintenance schedule.", "The network management system 1601 can at step 1754 identify from the maintenance information, maintenance activities to be performed during the maintenance schedule.", "From these activities, the network management system 1601 can detect a disturbance resulting from the maintenance (e.g., scheduled replacement of a power line 1610, scheduled replacement of a waveguide system 1602 on the power line 1610, scheduled reconfiguration of power lines 1610 in the power grid 1653, etc.).", "In another embodiment, the network management system 1601 can receive at step 1755 telemetry information from one or more waveguide systems 1602.The telemetry information can include among other things an identity of each waveguide system 1602 submitting the telemetry information, measurements taken by sensors 1604 of each waveguide system 1602, information relating to predicted, estimated, or actual disturbances detected by the sensors 1604 of each waveguide system 1602, location information associated with each waveguide system 1602, an estimated location of a detected disturbance, an identification of the disturbance, and so on.", "The network management system 1601 can determine from the telemetry information a type of disturbance that may be adverse to operations of the waveguide, transmission of the electromagnetic waves along the wire surface, or both.", "The network management system 1601 can also use telemetry information from multiple waveguide systems 1602 to isolate and identify the disturbance.", "Additionally, the network management system 1601 can request telemetry information from waveguide systems 1602 in a vicinity of an affected waveguide system 1602 to triangulate a location of the disturbance and/or validate an identification of the disturbance by receiving similar telemetry information from other waveguide systems 1602.In yet another embodiment, the network management system 1601 can receive at step 1756 an unscheduled activity report from maintenance field personnel.", "Unscheduled maintenance may occur as result of field calls that are unplanned or as a result of unexpected field issues discovered during field calls or scheduled maintenance activities.", "The activity report can identify changes to a topology configuration of the power grid 1653 resulting from field personnel addressing discovered issues in the communication system 1655 and/or power grid 1653, changes to one or more waveguide systems 1602 (such as replacement or repair thereof), mitigation of disturbances performed if any, and so on.", "At step 1758, the network management system 1601 can determine from reports received according to steps 1752 through 1756 if a disturbance will occur based on a maintenance schedule, or if a disturbance has occurred or is predicted to occur based on telemetry data, or if a disturbance has occurred due to an unplanned maintenance identified in a field activity report.", "From any of these reports, the network management system 1601 can determine whether a detected or predicted disturbance requires rerouting of traffic by the affected waveguide systems 1602 or other waveguide systems 1602 of the communication system 1655.When a disturbance is detected or predicted at step 1758, the network management system 1601 can proceed to step 1760 where it can direct one or more waveguide systems 1602 to reroute traffic to circumvent the disturbance.", "When the disturbance is permanent due to a permanent topology change of the power grid 1653, the network management system 1601 can proceed to step 1770 and skip steps 1762, 1764, 1766, and 1772.At step 1770, the network management system 1601 can direct one or more waveguide systems 1602 to use a new routing configuration that adapts to the new topology.", "However, when the disturbance has been detected from telemetry information supplied by one or more waveguide systems 1602, the network management system 1601 can notify maintenance personnel of the utility company 1656 or the communications service provider 1658 of a location of the disturbance, a type of disturbance if known, and related information that may be helpful to such personnel to mitigate the disturbance.", "When a disturbance is expected due to maintenance activities, the network management system 1601 can direct one or more waveguide systems 1602 to reconfigure traffic routes at a given schedule (consistent with the maintenance schedule) to avoid disturbances caused by the maintenance activities during the maintenance schedule.", "Returning back to step 1760 and upon its completion, the process can continue with step 1762.At step 1762, the network management system 1601 can monitor when the disturbance(s) have been mitigated by field personnel.", "Mitigation of a disturbance can be detected at step 1762 by analyzing field reports submitted to the network management system 1601 by field personnel over a communications network (e.g., cellular communication system) utilizing field equipment (e.g., a laptop computer or handheld computer/device).", "If field personnel have reported that a disturbance has been mitigated, the network management system 1601 can proceed to step 1764 to determine from the field report whether a topology change was required to mitigate the disturbance.", "A topology change can include rerouting a power line 1610, reconfiguring a waveguide system 1602 to utilize a different power line 1610, otherwise utilizing an alternative link to bypass the disturbance and so on.", "If a topology change has taken place, the network management system 1601 can direct at step 1770 one or more waveguide systems 1602 to use a new routing configuration that adapts to the new topology.", "If, however, a topology change has not been reported by field personnel, the network management system 1601 can proceed to step 1766 where it can direct one or more waveguide systems 1602 to send test signals to test a routing configuration that had been used prior to the detected disturbance(s).", "Test signals can be sent to affected waveguide systems 1602 in a vicinity of the disturbance.", "The test signals can be used to determine if signal disturbances (e.g., electromagnetic wave reflections) are detected by any of the waveguide systems 1602.If the test signals confirm that a prior routing configuration is no longer subject to previously detected disturbance(s), then the network management system 1601 can at step 1772 direct the affected waveguide systems 1602 to restore a previous routing configuration.", "If, however, test signals analyzed by one or more waveguide coupling device 1402 and reported to the network management system 1601 indicate that the disturbance(s) or new disturbance(s) are present, then the network management system 1601 will proceed to step 1768 and report this information to field personnel to further address field issues.", "The network management system 1601 can in this situation continue to monitor mitigation of the disturbance(s) at step 1762.In the aforementioned embodiments, the waveguide systems 1602 can be configured to be self-adapting to changes in the power grid 1653 and/or to mitigation of disturbances.", "That is, one or more affected waveguide systems 1602 can be configured to self-monitor mitigation of disturbances and reconfigure traffic routes without requiring instructions to be sent to them by the network management system 1601.In this embodiment, the one or more waveguide systems 1602 that are self-configurable can inform the network management system 1601 of its routing choices so that the network management system 1601 can maintain a macro-level view of the communication topology of the communication system 1655.While for purposes of simplicity of explanation, the respective processes are shown and described as a series of blocks in FIGS.", "17A and 17B, respectively, it is to be understood and appreciated that the claimed subject matter is not limited by the order of the blocks, as some blocks may occur in different orders and/or concurrently with other blocks from what is depicted and described herein.", "Moreover, not all illustrated blocks may be required to implement the methods described herein.", "Turning now to FIG.", "18, a block diagram illustrating an example, non-limiting embodiment of a cross-sectional view of transmission media 1800 in accordance with various aspects described herein is shown.", "In one embodiment, transmission media 1800 can comprise a bundle of power lines sharing a common cable.", "FIG.", "18 depicts a first power line 1804, a second power line 1806, and a third power line 1808 sharing a common cable 1802.Other configurations of more or less power lines can be used in accordance with the embodiments of the subject disclosure.", "The power lines 1804, 1806 and 1808 and common cable 1802 can be coupled to multiple spacers such as the spacer 1900 depicted in FIG.", "19.Each spacer 1900 can have clamps 1902 which can be used to support the power lines 1804, 1806 and 1808 and the common cable 1802.For power lines held by utility poles over long distances, the spacers 1900 can be separated longitudinally from each other such as to achieve a uniform spacing between the power lines 1804, 1806 and 1808 and the common cable 1802.The power lines 1804, 1806 and 1808 can be constructed with insulated or uninsulated conductors.", "Similarly, the common cable 1802 can be an insulated or uninsulated conductor.", "The separation between the common cable 1802 and the first power line 1804 can form a first twin-lead cable, which can be used for propagating a first electromagnetic wave 1804′ that propagates longitudinally along the first power line 1804 and the common cable 1802 (i.e., out of the page).", "Similarly, the separation between the common cable 1802 and the second power line 1806 can form a second twin-lead cable, which can be used for propagating a second electromagnetic wave 1806′ that propagates longitudinally along the second power line 1806 and the common cable 1802.Lastly, the separation between the common cable 1802 and the third power line 1808 can form a third twin-lead cable, which can be used for propagating a third electromagnetic wave 1808′ that propagates longitudinally along the third power line 1806 and the common cable 1802.Each twin-lead can serve as a transmission line for propagation of guided electromagnetic waves.", "From the illustration of FIG.", "18, a relationship exists between the number of cables and the number of twin-leads that can be used.", "Particularly, N−1 twin-leads can be formed from a bundle of cables, where N is a sum of a total number of power lines and the common cable.", "Based on FIG.", "18, 3 twin-lead cables (4 total cables−1) are possible.", "Each twin-lead cable can have an impedance range (e.g., from 600 ohms to 75 ohms) that determines an operating frequency range of electromagnetic waves that can be guided by each twin-lead cable (e.g., 3 KHz to 300 GHz).", "The embodiments of FIGS.", "18-19 can also be combined with the embodiments described earlier for transporting electromagnetic waves on a single transmission medium.", "For example, a waveguide system 1602 such as described earlier in FIG.", "16A can be configured to exchange electromagnetic waves with other waveguide systems 1602 over the first power line 1804, while at the same time another system exchanges electromagnetic waves guided by the twin-lead comprising the first power line 1804 and the common cable 1802.Guided electromagnetic waves can also be transmitted individually on the second power line 1806, the third power line 1808 and the common cable 1802.Accordingly, the configuration of FIG.", "18, can be used as seven communication pathways: A) three communication pathways via the three twin-lead cables, and B) four communication pathways via the four cables used for exchanging electromagnetic waves traveling on an outer surface of each cable.", "Turning now to FIG.", "20, illustrates a flow diagram of an example, non-limiting embodiment of a method 2000 that can be used for exchanging electromagnetic waves with transmission lines depicted in FIG.", "18 in accordance with various aspects described herein is shown.", "Method 2002 can begin with a plurality of launchers receiving a plurality of communication signals.", "Each launcher can be configured to receive a select one of the communication signals.", "Each communication signal can include data such as voice, streaming content or other forms of communication data generated by different sources.", "At step 2004, the launchers can be configured to transmit a plurality of electromagnetic waves by way of the bundle of transmission media 1800 such as shown in FIG.", "18.Each twin-lead of the bundle of transmission media 1800, for example, can be connected to a launcher (not shown) which can launch between the power line and the common cable forming the twin-lead an electromagnetic wave guided by the twin-lead, which can propagate longitudinally to a receiver (not shown) at a downstream location.", "The launcher can be a radio frequency (RF) transmitter that includes RF circuits for modulating and transmitting RF signals.", "Similarly, the receiver can be an RF receiver that includes RF circuits for receiving and demodulating RF signals.", "At step 2006, downstream receivers, each coupled to a particular twin-lead of the bundle of transmission media 1800, can receive the electromagnetic wave and retrieve at step 2008 a corresponding communication signal.", "For bi-directional communications, method 2000 can be adapted so that launchers and receivers are combined to form transceivers at each end such as the transmission devices 101 and 102 of FIG.", "1 for transmitting guided waves 120 and 122, respectively.", "As noted earlier, the individual cables of the bundled transmission media 1800 can also be used for exchanging electromagnetic waves on an outer surface of each cable.", "Accordingly, method 2000 can be adapted to use waveguide systems to add more communication pathways if so desired.", "While for purposes of simplicity of explanation, the respective processes are shown and described as a series of blocks in FIG.", "20, it is to be understood and appreciated that the claimed subject matter is not limited by the order of the blocks, as some blocks may occur in different orders and/or concurrently with other blocks from what is depicted and described herein.", "Moreover, not all illustrated blocks may be required to implement the methods described herein.", "Referring now to FIG.", "21, there is illustrated a block diagram of a computing environment in accordance with various aspects described herein.", "In order to provide additional context for various embodiments of the embodiments described herein, FIG.", "21 and the following discussion are intended to provide a brief, general description of a suitable computing environment 2100 in which the various embodiments of the subject disclosure can be implemented.", "While the embodiments have been described above in the general context of computer-executable instructions that can run on one or more computers, those skilled in the art will recognize that the embodiments can be also implemented in combination with other program modules and/or as a combination of hardware and software.", "Generally, program modules comprise routines, programs, components, data structures, etc., that perform particular tasks or implement particular abstract data types.", "Moreover, those skilled in the art will appreciate that the inventive methods can be practiced with other computer system configurations, comprising single-processor or multiprocessor computer systems, minicomputers, mainframe computers, as well as personal computers, hand-held computing devices, microprocessor-based or programmable consumer electronics, and the like, each of which can be operatively coupled to one or more associated devices.", "As used herein, a processing circuit includes processor as well as other application specific circuits such as an application specific integrated circuit, digital logic circuit, state machine, programmable gate array or other circuit that processes input signals or data and that produces output signals or data in response thereto.", "It should be noted that while any functions and features described herein in association with the operation of a processor could likewise be performed by a processing circuit.", "The terms “first,” “second,” “third,” and so forth, as used in the claims, unless otherwise clear by context, is for clarity only and doesn't otherwise indicate or imply any order in time.", "For instance, “a first determination,” “a second determination,” and “a third determination,” does not indicate or imply that the first determination is to be made before the second determination, or vice versa, etc.", "The illustrated embodiments of the embodiments herein can be also practiced in distributed computing environments where certain tasks are performed by remote processing devices that are linked through a communications network.", "In a distributed computing environment, program modules can be located in both local and remote memory storage devices.", "Computing devices typically comprise a variety of media, which can comprise computer-readable storage media and/or communications media, which two terms are used herein differently from one another as follows.", "Computer-readable storage media can be any available storage media that can be accessed by the computer and comprises both volatile and nonvolatile media, removable and non-removable media.", "By way of example, and not limitation, computer-readable storage media can be implemented in connection with any method or technology for storage of information such as computer-readable instructions, program modules, structured data or unstructured data.", "Computer-readable storage media can comprise, but are not limited to, random access memory (RAM), read only memory (ROM), electrically erasable programmable read only memory (EEPROM),flash memory or other memory technology, compact disk read only memory (CD-ROM), digital versatile disk (DVD) or other optical disk storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices or other tangible and/or non-transitory media which can be used to store desired information.", "In this regard, the terms “tangible” or “non-transitory” herein as applied to storage, memory or computer-readable media, are to be understood to exclude only propagating transitory signals per se as modifiers and do not relinquish rights to all standard storage, memory or computer-readable media that are not only propagating transitory signals per se.", "Computer-readable storage media can be accessed by one or more local or remote computing devices, e.g., via access requests, queries or other data retrieval protocols, for a variety of operations with respect to the information stored by the medium.", "Communications media typically embody computer-readable instructions, data structures, program modules or other structured or unstructured data in a data signal such as a modulated data signal, e.g., a carrier wave or other transport mechanism, and comprises any information delivery or transport media.", "The term “modulated data signal” or signals refers to a signal that has one or more of its characteristics set or changed in such a manner as to encode information in one or more signals.", "By way of example, and not limitation, communication media comprise wired media, such as a wired network or direct-wired connection, and wireless media such as acoustic, RF, infrared and other wireless media.", "With reference again to FIG.", "21, the example environment 2100 for transmitting and receiving signals via or forming at least part of a base station (e.g., base station devices 1504, macrocell site 1502, or base stations 1614) or central office (e.g., central office 1501 or 1611).", "At least a portion of the example environment 2100 can also be used for transmission devices 101 or 102.The example environment can comprise a computer 2102, the computer 2102 comprising a processing unit 2104, a system memory 2106 and a system bus 2108.The system bus 2108 couples system components including, but not limited to, the system memory 2106 to the processing unit 2104.The processing unit 2104 can be any of various commercially available processors.", "Dual microprocessors and other multiprocessor architectures can also be employed as the processing unit 2104.The system bus 2108 can be any of several types of bus structure that can further interconnect to a memory bus (with or without a memory controller), a peripheral bus, and a local bus using any of a variety of commercially available bus architectures.", "The system memory 2106 comprises ROM 2110 and RAM 2112.A basic input/output system (BIOS) can be stored in a non-volatile memory such as ROM, erasable programmable read only memory (EPROM), EEPROM, which BIOS contains the basic routines that help to transfer information between elements within the computer 2102, such as during startup.", "The RAM 2112 can also comprise a high-speed RAM such as static RAM for caching data.", "The computer 2102 further comprises an internal hard disk drive (HDD) 2114 (e.g., EIDE, SATA), which internal hard disk drive 2114 can also be configured for external use in a suitable chassis (not shown), a magnetic floppy disk drive (FDD) 2116, (e.g., to read from or write to a removable diskette 2118) and an optical disk drive 2120, (e.g., reading a CD-ROM disk 2122 or, to read from or write to other high capacity optical media such as the DVD).", "The hard disk drive 2114, magnetic disk drive 2116 and optical disk drive 2120 can be connected to the system bus 2108 by a hard disk drive interface 2124, a magnetic disk drive interface 2126 and an optical drive interface 2128, respectively.", "The interface 2124 for external drive implementations comprises at least one or both of Universal Serial Bus (USB) and Institute of Electrical and Electronics Engineers (IEEE) 1394 interface technologies.", "Other external drive connection technologies are within contemplation of the embodiments described herein.", "The drives and their associated computer-readable storage media provide nonvolatile storage of data, data structures, computer-executable instructions, and so forth.", "For the computer 2102, the drives and storage media accommodate the storage of any data in a suitable digital format.", "Although the description of computer-readable storage media above refers to a hard disk drive (HDD), a removable magnetic diskette, and a removable optical media such as a CD or DVD, it should be appreciated by those skilled in the art that other types of storage media which are readable by a computer, such as zip drives, magnetic cassettes, flash memory cards, cartridges, and the like, can also be used in the example operating environment, and further, that any such storage media can contain computer-executable instructions for performing the methods described herein.", "A number of program modules can be stored in the drives and RAM 2112, comprising an operating system 2130, one or more application programs 2132, other program modules 2134 and program data 2136.All or portions of the operating system, applications, modules, and/or data can also be cached in the RAM 2112.The systems and methods described herein can be implemented utilizing various commercially available operating systems or combinations of operating systems.", "Examples of application programs 2132 that can be implemented and otherwise executed by processing unit 2104 include the diversity selection determining performed by transmission device 101 or 102.A user can enter commands and information into the computer 2102 through one or more wired/wireless input devices, e.g., a keyboard 2138 and a pointing device, such as a mouse 2140.Other input devices (not shown) can comprise a microphone, an infrared (IR) remote control, a joystick, a game pad, a stylus pen, touch screen or the like.", "These and other input devices are often connected to the processing unit 2104 through an input device interface 2142 that can be coupled to the system bus 2108, but can be connected by other interfaces, such as a parallel port, an IEEE 1394 serial port, a game port, a universal serial bus (USB) port, an IR interface, etc.", "A monitor 2144 or other type of display device can be also connected to the system bus 2108 via an interface, such as a video adapter 2146.It will also be appreciated that in alternative embodiments, a monitor 2144 can also be any display device (e.g., another computer having a display, a smart phone, a tablet computer, etc.)", "for receiving display information associated with computer 2102 via any communication means, including via the Internet and cloud-based networks.", "In addition to the monitor 2144, a computer typically comprises other peripheral output devices (not shown), such as speakers, printers, etc.", "The computer 2102 can operate in a networked environment using logical connections via wired and/or wireless communications to one or more remote computers, such as a remote computer(s) 2148.The remote computer(s) 2148 can be a workstation, a server computer, a router, a personal computer, portable computer, microprocessor-based entertainment appliance, a peer device or other common network node, and typically comprises many or all of the elements described relative to the computer 2102, although, for purposes of brevity, only a memory/storage device 2150 is illustrated.", "The logical connections depicted comprise wired/wireless connectivity to a local area network (LAN) 2152 and/or larger networks, e.g., a wide area network (WAN) 2154.Such LAN and WAN networking environments are commonplace in offices and companies, and facilitate enterprise-wide computer networks, such as intranets, all of which can connect to a global communications network, e.g., the Internet.", "When used in a LAN networking environment, the computer 2102 can be connected to the local network 2152 through a wired and/or wireless communication network interface or adapter 2156.The adapter 2156 can facilitate wired or wireless communication to the LAN 2152, which can also comprise a wireless AP disposed thereon for communicating with the wireless adapter 2156.When used in a WAN networking environment, the computer 2102 can comprise a modem 2158 or can be connected to a communications server on the WAN 2154 or has other means for establishing communications over the WAN 2154, such as by way of the Internet.", "The modem 2158, which can be internal or external and a wired or wireless device, can be connected to the system bus 2108 via the input device interface 2142.In a networked environment, program modules depicted relative to the computer 2102 or portions thereof, can be stored in the remote memory/storage device 2150.It will be appreciated that the network connections shown are example and other means of establishing a communications link between the computers can be used.", "The computer 2102 can be operable to communicate with any wireless devices or entities operatively disposed in wireless communication, e.g., a printer, scanner, desktop and/or portable computer, portable data assistant, communications satellite, any piece of equipment or location associated with a wirelessly detectable tag (e.g., a kiosk, news stand, restroom), and telephone.", "This can comprise Wireless Fidelity (Wi-Fi) and BLUETOOTH® wireless technologies.", "Thus, the communication can be a predefined structure as with a conventional network or simply an ad hoc communication between at least two devices.", "Wi-Fi can allow connection to the Internet from a couch at home, a bed in a hotel room or a conference room at work, without wires.", "Wi-Fi is a wireless technology similar to that used in a cell phone that enables such devices, e.g., computers, to send and receive data indoors and out; anywhere within the range of a base station.", "Wi-Fi networks use radio technologies called IEEE 802.11 (a, b, g, n, ac, ag etc.)", "to provide secure, reliable, fast wireless connectivity.", "A Wi-Fi network can be used to connect computers to each other, to the Internet, and to wired networks (which can use IEEE 802.3 or Ethernet).", "Wi-Fi networks operate in the unlicensed 2.4 and 5 GHz radio bands for example or with products that contain both bands (dual band), so the networks can provide real-world performance similar to the basic 10BaseT wired Ethernet networks used in many offices.", "FIG.", "22 presents an example embodiment 2200 of a mobile network platform 2210 that can implement and exploit one or more aspects of the disclosed subject matter described herein.", "In one or more embodiments, the mobile network platform 2210 can generate and receive signals transmitted and received by base stations (e.g., base station devices 1504, macrocell site 1502, or base stations 1614), central office (e.g., central office 1501 or 1611),or transmission device 101 or 102 associated with the disclosed subject matter.", "Generally, wireless network platform 2210 can comprise components, e.g., nodes, gateways, interfaces, servers, or disparate platforms, that facilitate both packet-switched (PS) (e.g., internet protocol (IP), frame relay, asynchronous transfer mode (ATM)) and circuit-switched (CS) traffic (e.g., voice and data), as well as control generation for networked wireless telecommunication.", "As a non-limiting example, wireless network platform 2210 can be included in telecommunications carrier networks, and can be considered carrier-side components as discussed elsewhere herein.", "Mobile network platform 2210 comprises CS gateway node(s) 2222 which can interface CS traffic received from legacy networks like telephony network(s) 2240 (e.g., public switched telephone network (PSTN), or public land mobile network (PLMN)) or a signaling system #7 (SS7) network 2270.Circuit switched gateway node(s) 2222 can authorize and authenticate traffic (e.g., voice) arising from such networks.", "Additionally, CS gateway node(s) 2222 can access mobility, or roaming, data generated through SS7 network 2270; for instance, mobility data stored in a visited location register (VLR), which can reside in memory 2230.Moreover, CS gateway node(s) 2222 interfaces CS-based traffic and signaling and PS gateway node(s) 2218.As an example, in a 3GPP UMTS network, CS gateway node(s) 2222 can be realized at least in part in gateway GPRS support node(s) (GGSN).", "It should be appreciated that functionality and specific operation of CS gateway node(s) 2222, PS gateway node(s) 2218, and serving node(s) 2216, is provided and dictated by radio technology(ies) utilized by mobile network platform 2210 for telecommunication.", "In addition to receiving and processing CS-switched traffic and signaling, PS gateway node(s) 2218 can authorize and authenticate PS-based data sessions with served mobile devices.", "Data sessions can comprise traffic, or content(s), exchanged with networks external to the wireless network platform 2210, like wide area network(s) (WANs) 2250, enterprise network(s) 2270, and service network(s) 2280, which can be embodied in local area network(s) (LANs), can also be interfaced with mobile network platform 2210 through PS gateway node(s) 2218.It is to be noted that WANs 2250 and enterprise network(s) 2260 can embody, at least in part, a service network(s) like IP multimedia subsystem (IMS).", "Based on radio technology layer(s) available in technology resource(s) 2217, packet-switched gateway node(s) 2218 can generate packet data protocol contexts when a data session is established; other data structures that facilitate routing of packetized data also can be generated.", "To that end, in an aspect, PS gateway node(s) 2218 can comprise a tunnel interface (e.g., tunnel termination gateway (TTG) in 3GPP UMTS network(s) (not shown)) which can facilitate packetized communication with disparate wireless network(s), such as Wi-Fi networks.", "In embodiment 2200, wireless network platform 2210 also comprises serving node(s) 2216 that, based upon available radio technology layer(s) within technology resource(s) 2217, convey the various packetized flows of data streams received through PS gateway node(s) 2218.It is to be noted that for technology resource(s) 2217 that rely primarily on CS communication, server node(s) can deliver traffic without reliance on PS gateway node(s) 2218; for example, server node(s) can embody at least in part a mobile switching center.", "As an example, in a 3GPP UMTS network, serving node(s) 2216 can be embodied in serving GPRS support node(s) (SGSN).", "For radio technologies that exploit packetized communication, server(s) 2214 in wireless network platform 2210 can execute numerous applications that can generate multiple disparate packetized data streams or flows, and manage (e.g., schedule, queue, format .", ".", ". )", "such flows.", "Such application(s) can comprise add-on features to standard services (for example, provisioning, billing, customer support .", ".", ". )", "provided by wireless network platform 2210.Data streams (e.g., content(s) that are part of a voice call or data session) can be conveyed to PS gateway node(s) 2218 for authorization/authentication and initiation of a data session, and to serving node(s) 2216 for communication thereafter.", "In addition to application server, server(s) 2214 can comprise utility server(s), a utility server can comprise a provisioning server, an operations and maintenance server, a security server that can implement at least in part a certificate authority and firewalls as well as other security mechanisms, and the like.", "In an aspect, security server(s) secure communication served through wireless network platform 2210 to ensure network's operation and data integrity in addition to authorization and authentication procedures that CS gateway node(s) 2222 and PS gateway node(s) 2218 can enact.", "Moreover, provisioning server(s) can provision services from external network(s) like networks operated by a disparate service provider; for instance, WAN 2250 or Global Positioning System (GPS) network(s) (not shown).", "Provisioning server(s) can also provision coverage through networks associated to wireless network platform 2210 (e.g., deployed and operated by the same service provider), such as the distributed antennas networks shown in FIG.", "1(s) that enhance wireless service coverage by providing more network coverage.", "Repeater devices such as those shown in FIGS.", "7, 8, and 9 also improve network coverage in order to enhance subscriber service experience by way of UE 2275.It is to be noted that server(s) 2214 can comprise one or more processors configured to confer at least in part the functionality of macro network platform 2210.To that end, the one or more processor can execute code instructions stored in memory 2230, for example.", "It is should be appreciated that server(s) 2214 can comprise a content manager 2215, which operates in substantially the same manner as described hereinbefore.", "In example embodiment 2200, memory 2230 can store information related to operation of wireless network platform 2210.Other operational information can comprise provisioning information of mobile devices served through wireless platform network 2210, subscriber databases; application intelligence, pricing schemes, e.g., promotional rates, flat-rate programs, couponing campaigns; technical specification(s) consistent with telecommunication protocols for operation of disparate radio, or wireless, technology layers; and so forth.", "Memory 2230 can also store information from at least one of telephony network(s) 2240, WAN 2250, enterprise network(s) 2270, or SS7 network 2260.In an aspect, memory 2230 can be, for example, accessed as part of a data store component or as a remotely connected memory store.", "In order to provide a context for the various aspects of the disclosed subject matter, FIG.", "22, and the following discussion, are intended to provide a brief, general description of a suitable environment in which the various aspects of the disclosed subject matter can be implemented.", "While the subject matter has been described above in the general context of computer-executable instructions of a computer program that runs on a computer and/or computers, those skilled in the art will recognize that the disclosed subject matter also can be implemented in combination with other program modules.", "Generally, program modules comprise routines, programs, components, data structures, etc.", "that perform particular tasks and/or implement particular abstract data types.", "FIG.", "23 depicts an illustrative embodiment of a communication device 2300.The communication device 2300 can serve as an illustrative embodiment of devices such as mobile devices and in-building devices referred to by the subject disclosure (e.g., in FIGS.", "15, 16A-16C).", "The communication device 2300 can comprise a wireline and/or wireless transceiver 2302 (herein transceiver 2302), a user interface (UI) 2304, a power supply 2314, a location receiver 2316, a motion sensor 2318, an orientation sensor 2320, and a controller 2306 for managing operations thereof.", "The transceiver 2302 can support short-range or long-range wireless access technologies such as Bluetooth®, ZigBee®, Wi-Fi, DECT, or cellular communication technologies, just to mention a few (Bluetooth® and ZigBee® are trademarks registered by the Bluetooth® Special Interest Group and the ZigBee® Alliance, respectively).", "Cellular technologies can include, for example, CDMA-1X, UMTS/HSDPA, GSM/GPRS, TDMA/EDGE, EV/DO, WiMAX, SDR, LTE, as well as other next generation wireless communication technologies as they arise.", "The transceiver 2302 can also be adapted to support circuit-switched wireline access technologies (such as PSTN), packet-switched wireline access technologies (such as TCP/IP, VoIP, etc.", "), and combinations thereof.", "The UI 2304 can include a depressible or touch-sensitive keypad 2308 with a navigation mechanism such as a roller ball, a joystick, a mouse, or a navigation disk for manipulating operations of the communication device 2300.The keypad 2308 can be an integral part of a housing assembly of the communication device 2300 or an independent device operably coupled thereto by a tethered wireline interface (such as a USB cable) or a wireless interface supporting for example Bluetooth®.", "The keypad 2308 can represent a numeric keypad commonly used by phones, and/or a QWERTY keypad with alphanumeric keys.", "The UI 2304 can further include a display 2310 such as monochrome or color LCD (Liquid Crystal Display), OLED (Organic Light Emitting Diode) or other suitable display technology for conveying images to an end user of the communication device 2300.In an embodiment where the display 2310 is touch-sensitive, a portion or all of the keypad 2308 can be presented by way of the display 2310 with navigation features.", "The display 2310 can use touch screen technology to also serve as a user interface for detecting user input.", "As a touch screen display, the communication device 2300 can be adapted to present a user interface having graphical user interface (GUI) elements that can be selected by a user with a touch of a finger.", "The touch screen display 2310 can be equipped with capacitive, resistive or other forms of sensing technology to detect how much surface area of a user's finger has been placed on a portion of the touch screen display.", "This sensing information can be used to control the manipulation of the GUI elements or other functions of the user interface.", "The display 2310 can be an integral part of the housing assembly of the communication device 2300 or an independent device communicatively coupled thereto by a tethered wireline interface (such as a cable) or a wireless interface.", "The UI 2304 can also include an audio system 2312 that utilizes audio technology for conveying low volume audio (such as audio heard in proximity of a human ear) and high volume audio (such as speakerphone for hands free operation).", "The audio system 2312 can further include a microphone for receiving audible signals of an end user.", "The audio system 2312 can also be used for voice recognition applications.", "The UI 2304 can further include an image sensor 2313 such as a charged coupled device (CCD) camera for capturing still or moving images.", "The power supply 2314 can utilize common power management technologies such as replaceable and rechargeable batteries, supply regulation technologies, and/or charging system technologies for supplying energy to the components of the communication device 2300 to facilitate long-range or short-range portable communications.", "Alternatively, or in combination, the charging system can utilize external power sources such as DC power supplied over a physical interface such as a USB port or other suitable tethering technologies.", "The location receiver 2316 can utilize location technology such as a global positioning system (GPS) receiver capable of assisted GPS for identifying a location of the communication device 2300 based on signals generated by a constellation of GPS satellites, which can be used for facilitating location services such as navigation.", "The motion sensor 2318 can utilize motion sensing technology such as an accelerometer, a gyroscope, or other suitable motion sensing technology to detect motion of the communication device 2300 in three-dimensional space.", "The orientation sensor 2320 can utilize orientation sensing technology such as a magnetometer to detect the orientation of the communication device 2300 (north, south, west, and east, as well as combined orientations in degrees, minutes, or other suitable orientation metrics).", "The communication device 2300 can use the transceiver 2302 to also determine a proximity to a cellular, Wi-Fi, Bluetooth®, or other wireless access points by sensing techniques such as utilizing a received signal strength indicator (RSSI) and/or signal time of arrival (TOA) or time of flight (TOF) measurements.", "The controller 2306 can utilize computing technologies such as a microprocessor, a digital signal processor (DSP), programmable gate arrays, application specific integrated circuits, and/or a video processor with associated storage memory such as Flash, ROM, RAM, SRAM, DRAM or other storage technologies for executing computer instructions, controlling, and processing data supplied by the aforementioned components of the communication device 2300.Other components not shown in FIG.", "23 can be used in one or more embodiments of the subject disclosure.", "For instance, the communication device 2300 can include a slot for adding or removing an identity module such as a Subscriber Identity Module (SIM) card or Universal Integrated Circuit Card (UICC).", "SIM or UICC cards can be used for identifying subscriber services, executing programs, storing subscriber data, and so on.", "In the subject specification, terms such as “store,” “storage,” “data store,” data storage,” “database,” and substantially any other information storage component relevant to operation and functionality of a component, refer to “memory components,” or entities embodied in a “memory” or components comprising the memory.", "It will be appreciated that the memory components described herein can be either volatile memory or nonvolatile memory, or can comprise both volatile and nonvolatile memory, by way of illustration, and not limitation, volatile memory, non-volatile memory, disk storage, and memory storage.", "Further, nonvolatile memory can be included in read only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable ROM (EEPROM), or flash memory.", "Volatile memory can comprise random access memory (RAM), which acts as external cache memory.", "By way of illustration and not limitation, RAM is available in many forms such as synchronous RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDR SDRAM), enhanced SDRAM (ESDRAM), Synchlink DRAM (SLDRAM), and direct Rambus RAM (DRRAM).", "Additionally, the disclosed memory components of systems or methods herein are intended to comprise, without being limited to comprising, these and any other suitable types of memory.", "Moreover, it will be noted that the disclosed subject matter can be practiced with other computer system configurations, comprising single-processor or multiprocessor computer systems, mini-computing devices, mainframe computers, as well as personal computers, hand-held computing devices (e.g., PDA, phone, smartphone, watch, tablet computers, netbook computers, etc.", "), microprocessor-based or programmable consumer or industrial electronics, and the like.", "The illustrated aspects can also be practiced in distributed computing environments where tasks are performed by remote processing devices that are linked through a communications network; however, some if not all aspects of the subject disclosure can be practiced on stand-alone computers.", "In a distributed computing environment, program modules can be located in both local and remote memory storage devices.", "Some of the embodiments described herein can also employ artificial intelligence (AI) to facilitate automating one or more features described herein.", "For example, artificial intelligence can be used in optional training controller 230 evaluate and select candidate frequencies, modulation schemes, MIMO modes, and/or guided wave modes in order to maximize transfer efficiency.", "The embodiments (e.g., in connection with automatically identifying acquired cell sites that provide a maximum value/benefit after addition to an existing communication network) can employ various AI-based schemes for carrying out various embodiments thereof.", "Moreover, the classifier can be employed to determine a ranking or priority of the each cell site of the acquired network.", "A classifier is a function that maps an input attribute vector, x=(x1, x2, x3, x4, .", ".", ".", ", xn), to a confidence that the input belongs to a class, that is, f(x)=confidence (class).", "Such classification can employ a probabilistic and/or statistical-based analysis (e.g., factoring into the analysis utilities and costs) to prognose or infer an action that a user desires to be automatically performed.", "A support vector machine (SVM) is an example of a classifier that can be employed.", "The SVM operates by finding a hypersurface in the space of possible inputs, which the hypersurface attempts to split the triggering criteria from the non-triggering events.", "Intuitively, this makes the classification correct for testing data that is near, but not identical to training data.", "Other directed and undirected model classification approaches comprise, e.g., naïve Bayes, Bayesian networks, decision trees, neural networks, fuzzy logic models, and probabilistic classification models providing different patterns of independence can be employed.", "Classification as used herein also is inclusive of statistical regression that is utilized to develop models of priority.", "As will be readily appreciated, one or more of the embodiments can employ classifiers that are explicitly trained (e.g., via a generic training data) as well as implicitly trained (e.g., via observing UE behavior, operator preferences, historical information, receiving extrinsic information).", "For example, SVMs can be configured via a learning or training phase within a classifier constructor and feature selection module.", "Thus, the classifier(s) can be used to automatically learn and perform a number of functions, including but not limited to determining according to a predetermined criteria which of the acquired cell sites will benefit a maximum number of subscribers and/or which of the acquired cell sites will add minimum value to the existing communication network coverage, etc.", "As used in some contexts in this application, in some embodiments, the terms “component,” “system” and the like are intended to refer to, or comprise, a computer-related entity or an entity related to an operational apparatus with one or more specific functionalities, wherein the entity can be either hardware, a combination of hardware and software, software, or software in execution.", "As an example, a component may be, but is not limited to being, a process running on a processor, a processor, an object, an executable, a thread of execution, computer-executable instructions, a program, and/or a computer.", "By way of illustration and not limitation, both an application running on a server and the server can be a component.", "One or more components may reside within a process and/or thread of execution and a component may be localized on one computer and/or distributed between two or more computers.", "In addition, these components can execute from various computer readable media having various data structures stored thereon.", "The components may communicate via local and/or remote processes such as in accordance with a signal having one or more data packets (e.g., data from one component interacting with another component in a local system, distributed system, and/or across a network such as the Internet with other systems via the signal).", "As another example, a component can be an apparatus with specific functionality provided by mechanical parts operated by electric or electronic circuitry, which is operated by a software or firmware application executed by a processor, wherein the processor can be internal or external to the apparatus and executes at least a part of the software or firmware application.", "As yet another example, a component can be an apparatus that provides specific functionality through electronic components without mechanical parts, the electronic components can comprise a processor therein to execute software or firmware that confers at least in part the functionality of the electronic components.", "While various components have been illustrated as separate components, it will be appreciated that multiple components can be implemented as a single component, or a single component can be implemented as multiple components, without departing from example embodiments.", "Further, the various embodiments can be implemented as a method, apparatus or article of manufacture using standard programming and/or engineering techniques to produce software, firmware, hardware or any combination thereof to control a computer to implement the disclosed subject matter.", "The term “article of manufacture” as used herein is intended to encompass a computer program accessible from any computer-readable device or computer-readable storage/communications media.", "For example, computer readable storage media can include, but are not limited to, magnetic storage devices (e.g., hard disk, floppy disk, magnetic strips), optical disks (e.g., compact disk (CD), digital versatile disk (DVD)), smart cards, and flash memory devices (e.g., card, stick, key drive).", "Of course, those skilled in the art will recognize many modifications can be made to this configuration without departing from the scope or spirit of the various embodiments.", "In addition, the words “example” and “exemplary” are used herein to mean serving as an instance or illustration.", "Any embodiment or design described herein as “example” or “exemplary” is not necessarily to be construed as preferred or advantageous over other embodiments or designs.", "Rather, use of the word example or exemplary is intended to present concepts in a concrete fashion.", "As used in this application, the term “or” is intended to mean an inclusive “or” rather than an exclusive “or”.", "That is, unless specified otherwise or clear from context, “X employs A or B” is intended to mean any of the natural inclusive permutations.", "That is, if X employs A; X employs B; or X employs both A and B, then “X employs A or B” is satisfied under any of the foregoing instances.", "In addition, the articles “a” and “an” as used in this application and the appended claims should generally be construed to mean “one or more” unless specified otherwise or clear from context to be directed to a singular form.", "Moreover, terms such as “user equipment,” “mobile station,” “mobile,” subscriber station,” “access terminal,” “terminal,” “handset,” “mobile device” (and/or terms representing similar terminology) can refer to a wireless device utilized by a subscriber or user of a wireless communication service to receive or convey data, control, voice, video, sound, gaming or substantially any data-stream or signaling-stream.", "The foregoing terms are utilized interchangeably herein and with reference to the related drawings.", "Furthermore, the terms “user,” “subscriber,” “customer,” “consumer” and the like are employed interchangeably throughout, unless context warrants particular distinctions among the terms.", "It should be appreciated that such terms can refer to human entities or automated components supported through artificial intelligence (e.g., a capacity to make inference based, at least, on complex mathematical formalisms), which can provide simulated vision, sound recognition and so forth.", "As employed herein, the term “processor” can refer to substantially any computing processing unit or device comprising, but not limited to comprising, single-core processors; single-processors with software multithread execution capability; multi-core processors; multi-core processors with software multithread execution capability; multi-core processors with hardware multithread technology; parallel platforms; and parallel platforms with distributed shared memory.", "Additionally, a processor can refer to an integrated circuit, an application specific integrated circuit (ASIC), a digital signal processor (DSP), a field programmable gate array (FPGA), a programmable logic controller (PLC), a complex programmable logic device (CPLD), a discrete gate or transistor logic, discrete hardware components or any combination thereof designed to perform the functions described herein.", "Processors can exploit nano-scale architectures such as, but not limited to, molecular and quantum-dot based transistors, switches and gates, in order to optimize space usage or enhance performance of user equipment.", "A processor can also be implemented as a combination of computing processing units.", "As used herein, terms such as “data storage,” data storage,” “database,” and substantially any other information storage component relevant to operation and functionality of a component, refer to “memory components,” or entities embodied in a “memory” or components comprising the memory.", "It will be appreciated that the memory components or computer-readable storage media, described herein can be either volatile memory or nonvolatile memory or can include both volatile and nonvolatile memory.", "What has been described above includes mere examples of various embodiments.", "It is, of course, not possible to describe every conceivable combination of components or methodologies for purposes of describing these examples, but one of ordinary skill in the art can recognize that many further combinations and permutations of the present embodiments are possible.", "Accordingly, the embodiments disclosed and/or claimed herein are intended to embrace all such alterations, modifications and variations that fall within the spirit and scope of the appended claims.", "Furthermore, to the extent that the term “includes” is used in either the detailed description or the claims, such term is intended to be inclusive in a manner similar to the term “comprising” as “comprising” is interpreted when employed as a transitional word in a claim.", "In addition, a flow diagram may include a “start” and/or “continue” indication.", "The “start” and “continue” indications reflect that the steps presented can optionally be incorporated in or otherwise used in conjunction with other routines.", "In this context, “start” indicates the beginning of the first step presented and may be preceded by other activities not specifically shown.", "Further, the “continue” indication reflects that the steps presented may be performed multiple times and/or may be succeeded by other activities not specifically shown.", "Further, while a flow diagram indicates a particular ordering of steps, other orderings are likewise possible provided that the principles of causality are maintained.", "As may also be used herein, the term(s) “operably coupled to”, “coupled to”, and/or “coupling” includes direct coupling between items and/or indirect coupling between items via one or more intervening items.", "Such items and intervening items include, but are not limited to, junctions, communication paths, components, circuit elements, circuits, functional blocks, and/or devices.", "As an example of indirect coupling, a signal conveyed from a first item to a second item may be modified by one or more intervening items by modifying the form, nature or format of information in a signal, while one or more elements of the information in the signal are nevertheless conveyed in a manner than can be recognized by the second item.", "In a further example of indirect coupling, an action in a first item can cause a reaction on the second item, as a result of actions and/or reactions in one or more intervening items.", "Although specific embodiments have been illustrated and described herein, it should be appreciated that any arrangement which achieves the same or similar purpose may be substituted for the embodiments described or shown by the subject disclosure.", "The subject disclosure is intended to cover any and all adaptations or variations of various embodiments.", "Combinations of the above embodiments, and other embodiments not specifically described herein, can be used in the subject disclosure.", "For instance, one or more features from one or more embodiments can be combined with one or more features of one or more other embodiments.", "In one or more embodiments, features that are positively recited can also be negatively recited and excluded from the embodiment with or without replacement by another structural and/or functional feature.", "The steps or functions described with respect to the embodiments of the subject disclosure can be performed in any order.", "The steps or functions described with respect to the embodiments of the subject disclosure can be performed alone or in combination with other steps or functions of the subject disclosure, as well as from other embodiments or from other steps that have not been described in the subject disclosure.", "Further, more than or less than all of the features described with respect to an embodiment can also be utilized." ] ]
Patent_15874083
[ [ "METHODS OF SYNTHESIZING A PROSTACYCLIN ANALOG", "The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl.", "The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods.", "The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride).", "Many of the processes of the present invention generate intermediates with improved e.e.", "and chemical purity; thereby eliminating the need of additional chromatography steps.", "And, the processes of the present invention are scalable to generate commercial quantities of the final compound." ], [ "1.A method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xv) reacting a compound of Formula 21 with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22 wherein R3 is C1-6 alkyl or phenyl; and xvi) converting the compound of Formula 22 to the compound of Formula I.", "2.The method of claim 1, wherein the transition metal catalyst of step xv) comprises a compound or complex either of which comprises Cu having a +1 oxidation state.", "3.The method of claim 2, wherein the transition metal catalyst of step xv) comprises CuX, wherein X is selected from halogen, acetate, benzoate, cyanide, hydroxide, nitrate, or any combination thereof.", "4.The method of claim 3, wherein the transition metal catalyst of step xv) comprises CuI.", "5.The method of claim 1, further comprising the steps of: xvii) reacting a compound of Formula 19 with R4-substituted benzenesulfonyl chloride under basic conditions to generate a compound of Formula 20, wherein each R4 is independently selected from —H or C1-3 alkyl; and xviii) reacting the compound of Formula 20 with methanol under basic conditions to generate the compound of Formula 21.6.The method of claim 5, further comprising the steps of xix) reacting a compound of Formula 16 with a reducing agent to generate a compound of Formula 17; xx) reacting the compound of Formula 17 with Si(R3)3Cl under basic conditions to generate a compound of Formula 18; and xxi) selectively deprotecting the compound of Formula 18 to generate the compound of Formula 19.7.The method of claim 6, further comprising the steps of: xii) hydrogenating a compound of Formula 15 in the presence of an alcohol or optionally substituted THF to generate the compound of Formula 16.8.The method of claim 7, further comprising the steps of: x) reacting a compound of Formula 12 with a reducing agent to generate a compound of Formula 13; and xiv) converting the compound of Formula 13 to the compound of Formula 15.9.The method of claim 8, wherein the reducing agent of step x) comprises a chiral borane compound.", "10.The method of claim 9, wherein the chiral borane compound is selected from (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-1-butyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, (4S)-2-methyl-4, 5,5-triphenyl-1,3,2-oxazaborolidine, or any combination thereof.", "11.The method of claim 8, further comprising the step of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises MnO2.12.The method of claim 11, further comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11 13.The method of claim 12, wherein the oxidizing agent of step i) comprises MnO2 or Dess-Martin periodinane.", "14.The method of claim 12, wherein the base of step ii) comprises an alkyllithium reagent.", "15.A method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xv) reacting a compound of Formula 21a with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22a wherein R1 is C1-6 alkyl; and xvi) converting the compound of Formula 22a to the compound of Formula I.", "16.The method of claim 15, wherein the transition metal catalyst comprises a compound or complex either of which comprises copper having a +1 oxidation state.", "17.The method of claim 16, wherein the transition metal catalyst comprises CuI.", "18.The method of claim 15, further comprising the steps of: xvii) reacting a compound of Formula 19a with triisopropylbenzenesulfonyl chloride under basic conditions to generate a compound of Formula 20a; and xviii) reacting the compound of Formula 20a with methanol under basic conditions to generate the compound of Formula 21a.", "19.The method of claim 18, further comprising the steps of xix) reacting a compound of Formula 16a with a reducing agent to generate a compound of Formula 17a; xx) reacting the compound of Formula 17a with TBDPSCl under basic conditions to generate a compound of Formula 18a; and xxi) selectively deprotecting the compound of Formula 18a to generate the compound of Formula 19a.", "20.The method of claim 19, further comprising the steps of: xii) hydrogenating a compound of Formula 15a in the presence of an alcohol, optionally substituted THF, or any combination thereof to generate the compound of Formula 16a.", "21.The method of claim 20, further comprising the steps of: x) reacting a compound of Formula 12a with a reducing agent to generate a compound of Formula 13a; and xiv) converting the compound of Formula 13a to the compound of Formula 15a.", "22.The method of claim 21, further comprising the step of: v) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO2.23.The method of claim 21, further comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a 24.The method of claim 23, further comprising the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "25.The method of claim 24, further comprising the steps of: xxii) reacting a compound of Formula 7a with a 3-haloprop-1-ene in the presence of a base and an organic solvent to generate a compound of Formula 8a; and xxiii) deprotecting the compound of Formula 8a to generate the compound of Formula 9.26.A method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a; iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; vii) converting the compound of Formula 3a to the compound of Formula 5a; viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO2; x) reacting a compound of Formula 12a with a reducing agent to generate a compound of Formula 13a; xiv) converting the compound of Formula 13a to the compound of Formula 15a; xii) hydrogenating a compound of Formula 15a in the presence of methanol, ethanol, THF, 2-methyl-THF, or any combination thereof to generate the compound of Formula 16a; xix) reacting a compound of Formula 16a with a reducing agent to generate a compound of Formula 17a; xx) reacting the compound of Formula 17a with TDPSCl under basic conditions to generate a compound of Formula 18a; xxi) selectively deprotecting the compound of Formula 18a to generate the compound of Formula 19a; xvii) reacting a compound of Formula 19a with triisopropylbenzenesulfonyl chloride under basic conditions to generate a compound of Formula 20a; xviii) reacting the compound of Formula 20a with methanol under basic conditions to generate the compound of Formula 21a; xv) reacting a compound of Formula 21a with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22a; and xvi) converting the compound of Formula 22a to the compound of Formula I.", "27.The method of claim 26, further comprising the step of: xxiv) reacting the compound of Formula I with diethanolamine in the presence of an organic solvent to generate the diethanolamine salt of the compound of Formula I.", "28.A compound of Formula 1a 29.A method of purifying a compound of Formula 1 comprising: xxx) reacting a compound of Formula 1 with a derivatizing reagent to generate a precipitate that is substantially insoluble in dichloromethane or mixtures thereof; xxxi) collecting the precipitate and refluxing the precipitate in a solvent comprising an alcohol to generate the compound of Formula 1 having a chemical purity of about 98% or greater and an e.e.", "of about 98% or greater; wherein the method excludes the use of any column chromatography.", "30.The method of claim 29, wherein the derivitizing reagent comprises 3,5-dinitrobenzoyl chloride and the alcohol comprises methanol.", "31.A method of purifying a compound of Formula 9 comprising: xl) reacting a compound of Formula 9, wherein R1 is C1-6 alkyl, with 3,5-dinitrobenzoyl chloride to generate a precipitate comprising a compound of Formula 9A; and xli) collecting the precipitate and treating the precipitate with a base in the presence of an alcohol to generate the compound of Formula 9 having a chemical purity of about 95% or greater; wherein the method excludes the use of any column chromatography.", "32.The method of claim 31, further comprising the step: xlii) recrystallizing the precipitate of step xli).", "33.A compound of Formula 9a wherein R1 is C1-6 alkyl.", "34.A compound of Formula 13 wherein R1 is C1-6 alkyl and each R2 is independently selected from C1-6 alkyl or phenyl.", "35.A method of generating a compound of Formula 13 wherein R1 is C1-6 alkyl and each R2 is independently selected from C1-6 alkyl or phenyl, comprising x) reacting a compound of Formula 12 with (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole in the presence of an organic solvent comprising THF and toluene to generate a compound of Formula 13 wherein the compound of Formula 13 has a chemical purity of about 97% or greater and a d.e.", "of about 97% or greater." ], [ "<SOH> BACKGROUND <EOH>Prostacyclin derivatives and analogs are useful pharmaceutical compounds possessing activities such as platelet aggregation inhibition, gastric secretion reduction, lesion inhibition, vasodilation, and bronchodilation.", "Treprostinil is a synthetic prostacyclin derivative currently marketed as an active pharmaceutical ingredient (API) for its ability to inhibit pulmonary arterial hypertension under the trade name Remodulin®.", "Treprostinil was first described in U.S. Pat.", "No.", "4,306,075.Prostacyclin derivatives are traditionally synthesized using a variety of methods that are described in J. Org.", "Chem.", "2004, 69, 1890-1902 , Drug of the Future, 2001, 26(4), 364-374, U.S. Pat.", "Nos.", "4,306,075; 6,441,245; 6,528,688; 6,700,025; 6,765,117; 6,809,223 and U.S. patent application publication nos.", "2009/0163738, 2011/0319641 A1, as well as Canadian patent application publication no.", "2710726 A1.The entire teachings of these documents are incorporated herein by reference in their entireties.", "Also disclosed in these publications are processes and intermediates useful for the preparation of Treprostinil.", "However, the methods of these teachings suffer from one or more problems including toxic oxidation reagents, reduced yields, elevated levels of impurities, poor scalability, and numerous chromatography steps to purify intermediates and final products.", "Thus, there remains a need for safe, scalable, efficient, and economical processes for the preparation of Treprostinil." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>As described herein, the present invention provides processes for preparing a prostacyclin analogue of Formula IA: or a pharmaceutically acceptable salt thereof, wherein R 10 is a linear or branched C 1-6 alkyl.", "The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods.", "The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride).", "Many of the processes of the present invention do not require additional chromatography for purification of intermediates and generate intermediates with improved e.e.", "and chemical purity.", "And, the processes of the present invention are scalable to generate commercial quantities of the final compound.", "One aspect of the present invention provides a method of generating a compound of Formula or a pharmaceutically acceptable salt thereof, comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein R 1 is C 1-6 alkyl and the oxidizing agent comprises MnO 2 or Dess-Martin periodinane; ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11, wherein each R 2 is independently selected from C 1-6 alkyl or phenyl; and iii) converting the compound of Formula 11 to the compound of Formula I.", "In some implementations, the organic solvent of step i) comprises a halogenated organic solvent.", "For example, the organic solvent of step i) comprises dichloromethane, chloroform, or any combination thereof.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the base of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R 2 ) 3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: viii) reacting a compound of Formula 11 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 12 wherein R 1 is C 1-6 alkyl, each R is independently selected from C 1-6 alkyl or phenyl, and the oxidizing agent comprises MnO 2 ; and ix) converting the compound of Formula 12 to the compound of Formula I.", "In some implementations, each of the —OSi(R 2 ) 3 groups in the compounds of Formulae 11 and 12 is independently selected from In some implementations, the organic solvent of step viii) comprises a halogenated organic solvent.", "In some examples, the halogenated organic solvent of step viii) comprises dichloromethane, chloroform, or any combination thereof.", "Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein R 1 is C 1-6 alkyl and the oxidizing agent comprises MnO 2 or Dess-Martin periodinane; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11.In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the alkyllithium reagent of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: x) reacting a compound of Formula 12 with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13 wherein the organic solvent comprises THF, R 1 is C 1-6 alkyl, and each R 2 is independently C 1-6 alkyl or phenyl; and xi) converting the compound of Formula 13 to the compound of Formula I.", "In some implementations, the reducing agent of step x) comprises a chiral borane compound.", "And, in some examples, the chiral borane compound is selected from (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-1-butyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, (4S)-2-methyl-4,5,5-triphenyl-1,3,2-oxazaborolidine, or any combination thereof.", "In some implementations, the organic solvent of step x) further comprises toluene.", "Some methods further comprise the step of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises MnO 2 Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11 In some implementations, the oxidizing agent comprises MnO 2 or Dess-Martin periodinane.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the alkyllithium reagent of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R 2 ) 3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xii) hydrogenating a compound of Formula 15 in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16 wherein R 1 is C 1-6 alkyl and each R 2 is independently selected from C 1-6 alkyl or phenyl; and xiii) converting the compound of Formula 16 to the compound of Formula I.", "Some methods further comprise the steps of: x) reacting a compound of Formula 12 with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13 wherein the organic solvent comprises THF; and xiv) converting the compound of Formula 13 to the compound of Formula 15.In some implementations, the reducing agent of step x) comprises a chiral borane compound.", "And, in some examples, the chiral borane compound is selected from (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-1-butyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, (4S)-2-methyl-4,5,5-triphenyl-1,3,2-oxazaborolidine, or any combination thereof.", "Some methods further comprise the steps of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises MnO 2 Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11 In some implementations, the oxidizing agent of step i) comprises MnO 2 or Dess-Martin periodinane.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the alkyllithium reagent of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R 2 ) 3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xv) reacting a compound of Formula 21 with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22 wherein R 3 is C 1-6 alkyl or phenyl; and xvi) converting the compound of Formula 22 to the compound of Formula I.", "In some implementations, the transition metal catalyst of step xv) comprises a compound or complex either of which comprises Cu having a +1 oxidation state.", "For example, the transition metal catalyst of step xv) comprises CuX, wherein X is selected from halogen, acetate, benzoate, cyanide, hydroxide, nitrate, or any combination thereof.", "In other examples, the transition metal catalyst of step xv) comprises CuI.", "Some methods further comprise the steps of: xvii) reacting a compound of Formula 19 with R 4 -substituted benzenesulfonyl chloride under basic conditions to generate a compound of Formula 20, wherein each R 4 is independently selected from —H or C 1-3 alkyl; and xviii) reacting the compound of Formula 20 with methanol under basic conditions to generate the compound of Formula 21.Some methods further comprise the steps of: xix) reacting a compound of Formula 16 with a reducing agent to generate a compound of Formula 17; xx) reacting the compound of Formula 17 with Si(R 3 ) 3 Cl under basic conditions to generate a compound of Formula 18; and xxi) selectively deprotecting the compound of Formula 18 to generate the compound of Formula 19.Some methods further comprise the steps of: xii) hydrogenating a compound of Formula 15 in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16.In some implementations, the hydrogenation of the compound of Formula 15 also occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).", "Some methods further comprise the steps of: x) reacting a compound of Formula 12 with a reducing agent to generate a compound of Formula 13; and xiv) converting the compound of Formula 13 to the compound of Formula 15.In some implementations, the reducing agent of step x) comprises a chiral borane compound.", "And, in some examples, the chiral borane compound is selected from (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-1-butyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, (4S)-2-methyl-4,5,5-triphenyl-1,3,2-oxazaborolidine, or any combination thereof.", "Some methods further comprise the step of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises MnO 2 .", "Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11 In some implementations, the oxidizing agent of step i) comprises MnO 2 or Dess-Martin periodinane.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the alkyllithium reagent of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having greater than about 99% e.e.", "; v) reacting the compound of Formula 1 with SiCl(R 2 ) 3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Some methods further comprise the steps of: xxii) reacting a compound of Formula 7 with a 3-haloprop-1-ene in the presence of a base and an organic solvent to generate a compound of Formula 8; and xxiii) deprotecting the compound of Formula 8 to generate the compound of Formula 9.Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xxii) reacting a compound of Formula 7, wherein R 1 is C 1-6 alkyl and each R 2 is independently selected from C 1-6 alkyl or phenyl, with a 3-haloprop-1-ene in the presence of a base and an organic solvent to generate a compound of xxiii) deprotecting the compound of Formula 8 to generate the compound of Formula 9, and xxiv) converting the compound of Formula 9 to the compound of Formula I, wherein the base of step xxii) comprises sec-butyl lithium.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein R 1 is C 1-6 alkyl and the oxidizing agent comprises MnO 2 or Dess-Martin periodinane; ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a; and iii) converting the compound of Formula 11a to the compound of Formula I.", "In some implementations, the organic solvent of step i) comprises a halogenated organic solvent.", "For example, the organic solvent of step i) comprises dichloromethane, chloroform, or any combination thereof.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the base of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: viii) reacting a compound of Formula 11a with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 12a wherein R 1 is C 1-6 alkyl and the oxidizing agent comprises MnO 2 ; and ix) converting the compound of Formula 12a to the compound of Formula I.", "In some implementations, the organic solvent of step viii) comprises a halogenated organic solvent.", "For example, the halogenated organic solvent of step viii) comprises dichloromethane, chloroform, or any combination thereof.", "Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein the oxidizing agent comprises MnO 2 or Dess-Martin periodinane; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a.", "In some implementations, the organic solvent of step i) comprises a halogenated organic solvent.", "For example, the organic solvent of step i) comprises dichloromethane, chloroform, or any combination thereof.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the base of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: x) reacting a compound of Formula 12a with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13a wherein the organic solvent comprises THF, R 1 is C 1-6 alkyl, and each R 2 is independently selected from C 1-6 alkyl or phenyl; and xi) converting the compound of Formula 13 to the compound of Formula I.", "In some implementations, the reducing agent of step x) comprises a chiral borane compound.", "And, in some examples, the chiral borane compound is selected from (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-1-butyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, (4S)-2-methyl-4,5,5-triphenyl-1,3,2-oxazaborolidine, or any combination thereof.", "In some implementations, the organic solvent of step x) comprises THF.", "In some implementations, the organic solvent of step x) further comprises toluene.", "Some methods further comprise the step of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO 2 Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a In some implementations, the oxidizing agent of step i) comprises MnO 2 or Dess-Martin periodinane.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the alkyllithium reagent of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xii) hydrogenating a compound of Formula 15a in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a wherein R 1 is C 1-6 alkyl; and xiii) converting the compound of Formula 16a to the compound of Formula I.", "In some implementations, the hydrogenation of the compound of Formula 15a also occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).", "Some methods further comprise the steps of: x) reacting a compound of Formula 12a with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13a wherein the organic solvent comprises THF; and xiv) converting the compound of Formula 13a to the compound of Formula 15a.", "Some methods further comprise the steps of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO 2 Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xv) reacting a compound of Formula 21a with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22a wherein R 1 is C 1-6 alkyl; and xvi) converting the compound of Formula 22a to the compound of Formula I.", "In some implementations, the transition metal catalyst of step xv) comprises a compound or complex either of which comprises Cu having a +1 oxidation state.", "For example, the transition metal catalyst of step xv) comprises CuX, wherein X is selected from halogen, acetate, benzoate, cyanide, hydroxide, nitrate, or any combination thereof.", "In other examples, the transition metal catalyst of step xv) comprises CuI.", "Some methods further comprise the steps of: xvii) reacting a compound of Formula 19a with triisopropylbenzenesulfonyl chloride under basic conditions to generate a compound of Formula 20a; and xviii) reacting the compound of Formula 20a with methanol under basic conditions to generate the compound of Formula 21a.", "Some methods further comprise the steps of: xix) reacting a compound of Formula 16a with a reducing agent to generate a compound of Formula 17a; xx) reacting the compound of Formula 17a with TBDPSCl under basic conditions to generate a compound of Formula 18a; and xxi) selectively deprotecting the compound of Formula 18a to generate the compound of Formula 19a.", "Some methods further comprise the step of: xii) hydrogenating a compound of Formula 15a in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a.", "In some implementations, the organic solvent of step xii) is anhydrous (e.g., anhydrous methanol or anhydrous THF).", "In some implementations, the hydrogenation of the compound of Formula 15a occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).", "Some methods further comprise the steps of: x) reacting a compound of Formula 12a with a reducing agent to generate a compound of Formula 13a; and xiv) converting the compound of Formula 13a to the compound of Formula 15a.", "Some methods further comprise the step of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO 2 .", "Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Some methods further comprise the steps of: xxii) reacting a compound of Formula 7a with a 3-haloprop-1-ene in the presence of a base and an organic solvent to generate a compound of Formula 8a; and xxiii) deprotecting the compound of Formula 8a to generate the compound of Formula 9.Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a; iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; vii) converting the compound of Formula 3a to the compound of Formula 5a; viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO 2 ; x) reacting a compound of Formula 12a with a reducing agent to generate a compound of Formula 13a; xiv) converting the compound of Formula 13a to the compound of Formula 15a; xii) hydrogenating a compound of Formula 15a in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a; xix) reacting a compound of Formula 16a with a reducing agent to generate a compound of Formula 17a; xx) reacting the compound of Formula 17a with TDPSCl under basic conditions to generate a compound of Formula 18a; xxi) selectively deprotecting the compound of Formula 18a to generate the compound of Formula 19a; xvii) reacting a compound of Formula 19a with triisopropylbenzenesulfonyl chloride under basic conditions to generate a compound of Formula 20a; xviii) reacting the compound of Formula 20a with methanol under basic conditions to generate the compound of Formula 21a; xv) reacting a compound of Formula 21a with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22a; and xvi) converting the compound of Formula 22a to the compound of Formula I.", "Some methods further comprise the step of: xxiv) reacting the compound of Formula I with diethanolamine in the presence of an organic solvent to generate the diethanolamine salt of the compound of Formula I.", "Another aspect of the present invention provides a compound of Formula 21 wherein R 1 is C 1-6 alkyl and each R 3 is independently C 1-6 alkyl or phenyl.", "In some embodiments, R 1 is methyl, ethyl, propyl, iso-propyl, butyl, sec-butyl, or tert-butyl.", "In other embodiments the —OSi(R 3 ) 3 group is selected from In some embodiments, R 1 is methyl and the —OSi(R 3 ) 3 group is Another aspect of the present invention provides a compound of Formula 1a Another aspect of the present invention provides a method of purifying a compound of Formula 1 comprising the steps of: xxx) reacting a compound of Formula 1 with a derivatizing reagent to generate a precipitate that is substantially insoluble in dichloromethane or mixtures thereof (e.g., a mixture of dichloromethane and an alkane (e.g., heptane)); xxxi) collecting the precipitate and refluxing the precipitate in a solvent comprising an alcohol to generate the compound of Formula 1 having a chemical purity of about 98% or greater and an e.e.", "of about 98% or greater; wherein the method excludes the use of any column chromatography.", "In some implementations, the derivitizing reagent comprises 3,5-dinitrobenzoyl chloride and the alcohol comprises methanol.", "Another aspect of the present invention provides a method of purifying a compound of Formula 9 comprising the steps of: xl) reacting a compound of Formula 9, wherein R 1 is C 1-6 alkyl, with 3,5-dinitrobenzoyl chloride to generate a precipitate comprising a compound of Formula 9A; and xli) collecting the precipitate and treating the precipitate with a base in the presence of an alcohol to generate the compound of Formula 9 having a chemical purity of about 95% or greater (e.g., about 98% or greater, or from about 95% to about 99.9%); wherein the method excludes the use of any column chromatography.", "Some methods further comprise the step of: xlii) recrystallizing the precipitate of step xli).", "Another aspect of the present invention provides a method of generating a compound of Formula 5 wherein each of R 2 is independently selected from a C 1-6 alkyl or phenyl, comprising the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R 2 ) 3 , wherein each R 2 is independently selected from C 1-6 alkyl or phenyl, under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; l) deprotecting the compound Formula 3 under basic condition to generate a compound of Formula 4, wherein each of R 4 and R 5 are H or —OSi(R 2 ) 3 ; and li) reacting the compound of Formula 4 with SiCl(R 2 ) 3 under basic conditions to generate the compound of Formula 5, wherein the compound of Formula 5 has a chemical purity of about 98% or greater and an e.e.", "of about 98% or greater (e.g., from about 99% to about 99.99%).", "Another aspect of the present invention provides a method of generating a compound of Formula 13 wherein R 1 is C 1-6 alkyl and each R 2 is independently selected from C 1-6 alkyl or phenyl, comprising the step of: x) reacting a compound of Formula 12 with (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole in the presence of an organic solvent comprising THF and toluene to generate a compound of Formula 13 wherein the compound of Formula 13 has a chemical purity of about 97% or greater and a d.e.", "of about 97% or greater.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS REFERENCE TO RELATED APPLICATION This application is a divisional application of U.S. patent application Ser.", "No.", "15/583,457, filed May 1, 2017, which is a divisional application of U.S. patent application Ser.", "No.", "14/650,234, filed Jun.", "5, 2015, which is a 35 U.S.C.", "§ 371 United States National Phase Application of PCT Application Serial No.", "PCT/US2013/073474, filed Dec. 6, 2013, which claims the benefit of and priority to U.S. provisional application Ser.", "No.", "61/734,672, filed Dec. 7, 2012, and 61/777,882, filed Mar.", "12, 2013.The entire contents of the aforementioned disclosures are incorporated herein by reference in their entirety.", "TECHNICAL FIELD OF THE INVENTION The present invention relates to processes and intermediates for the preparation of prostacyclin analog that are useful for treating hypertension and other diseases.", "BACKGROUND Prostacyclin derivatives and analogs are useful pharmaceutical compounds possessing activities such as platelet aggregation inhibition, gastric secretion reduction, lesion inhibition, vasodilation, and bronchodilation.", "Treprostinil is a synthetic prostacyclin derivative currently marketed as an active pharmaceutical ingredient (API) for its ability to inhibit pulmonary arterial hypertension under the trade name Remodulin®.", "Treprostinil was first described in U.S. Pat.", "No.", "4,306,075.Prostacyclin derivatives are traditionally synthesized using a variety of methods that are described in J. Org.", "Chem.", "2004, 69, 1890-1902, Drug of the Future, 2001, 26(4), 364-374, U.S. Pat.", "Nos.", "4,306,075; 6,441,245; 6,528,688; 6,700,025; 6,765,117; 6,809,223 and U.S. patent application publication nos.", "2009/0163738, 2011/0319641 A1, as well as Canadian patent application publication no.", "2710726 A1.The entire teachings of these documents are incorporated herein by reference in their entireties.", "Also disclosed in these publications are processes and intermediates useful for the preparation of Treprostinil.", "However, the methods of these teachings suffer from one or more problems including toxic oxidation reagents, reduced yields, elevated levels of impurities, poor scalability, and numerous chromatography steps to purify intermediates and final products.", "Thus, there remains a need for safe, scalable, efficient, and economical processes for the preparation of Treprostinil.", "SUMMARY OF THE INVENTION As described herein, the present invention provides processes for preparing a prostacyclin analogue of Formula IA: or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl.", "The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods.", "The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride).", "Many of the processes of the present invention do not require additional chromatography for purification of intermediates and generate intermediates with improved e.e.", "and chemical purity.", "And, the processes of the present invention are scalable to generate commercial quantities of the final compound.", "One aspect of the present invention provides a method of generating a compound of Formula or a pharmaceutically acceptable salt thereof, comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein R1 is C1-6 alkyl and the oxidizing agent comprises MnO2 or Dess-Martin periodinane; ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11, wherein each R2 is independently selected from C1-6 alkyl or phenyl; and iii) converting the compound of Formula 11 to the compound of Formula I.", "In some implementations, the organic solvent of step i) comprises a halogenated organic solvent.", "For example, the organic solvent of step i) comprises dichloromethane, chloroform, or any combination thereof.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the base of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R2)3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: viii) reacting a compound of Formula 11 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 12 wherein R1 is C1-6 alkyl, each R is independently selected from C1-6 alkyl or phenyl, and the oxidizing agent comprises MnO2; and ix) converting the compound of Formula 12 to the compound of Formula I.", "In some implementations, each of the —OSi(R2)3 groups in the compounds of Formulae 11 and 12 is independently selected from In some implementations, the organic solvent of step viii) comprises a halogenated organic solvent.", "In some examples, the halogenated organic solvent of step viii) comprises dichloromethane, chloroform, or any combination thereof.", "Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein R1 is C1-6 alkyl and the oxidizing agent comprises MnO2 or Dess-Martin periodinane; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11.In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the alkyllithium reagent of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: x) reacting a compound of Formula 12 with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13 wherein the organic solvent comprises THF, R1 is C1-6 alkyl, and each R2 is independently C1-6 alkyl or phenyl; and xi) converting the compound of Formula 13 to the compound of Formula I.", "In some implementations, the reducing agent of step x) comprises a chiral borane compound.", "And, in some examples, the chiral borane compound is selected from (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-1-butyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, (4S)-2-methyl-4,5,5-triphenyl-1,3,2-oxazaborolidine, or any combination thereof.", "In some implementations, the organic solvent of step x) further comprises toluene.", "Some methods further comprise the step of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises MnO2 Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11 In some implementations, the oxidizing agent comprises MnO2 or Dess-Martin periodinane.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the alkyllithium reagent of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R2)3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xii) hydrogenating a compound of Formula 15 in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16 wherein R1 is C1-6 alkyl and each R2 is independently selected from C1-6 alkyl or phenyl; and xiii) converting the compound of Formula 16 to the compound of Formula I.", "Some methods further comprise the steps of: x) reacting a compound of Formula 12 with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13 wherein the organic solvent comprises THF; and xiv) converting the compound of Formula 13 to the compound of Formula 15.In some implementations, the reducing agent of step x) comprises a chiral borane compound.", "And, in some examples, the chiral borane compound is selected from (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-1-butyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, (4S)-2-methyl-4,5,5-triphenyl-1,3,2-oxazaborolidine, or any combination thereof.", "Some methods further comprise the steps of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises MnO2 Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11 In some implementations, the oxidizing agent of step i) comprises MnO2 or Dess-Martin periodinane.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the alkyllithium reagent of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R2)3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xv) reacting a compound of Formula 21 with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22 wherein R3 is C1-6 alkyl or phenyl; and xvi) converting the compound of Formula 22 to the compound of Formula I.", "In some implementations, the transition metal catalyst of step xv) comprises a compound or complex either of which comprises Cu having a +1 oxidation state.", "For example, the transition metal catalyst of step xv) comprises CuX, wherein X is selected from halogen, acetate, benzoate, cyanide, hydroxide, nitrate, or any combination thereof.", "In other examples, the transition metal catalyst of step xv) comprises CuI.", "Some methods further comprise the steps of: xvii) reacting a compound of Formula 19 with R4-substituted benzenesulfonyl chloride under basic conditions to generate a compound of Formula 20, wherein each R4 is independently selected from —H or C1-3 alkyl; and xviii) reacting the compound of Formula 20 with methanol under basic conditions to generate the compound of Formula 21.Some methods further comprise the steps of: xix) reacting a compound of Formula 16 with a reducing agent to generate a compound of Formula 17; xx) reacting the compound of Formula 17 with Si(R3)3Cl under basic conditions to generate a compound of Formula 18; and xxi) selectively deprotecting the compound of Formula 18 to generate the compound of Formula 19.Some methods further comprise the steps of: xii) hydrogenating a compound of Formula 15 in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16.In some implementations, the hydrogenation of the compound of Formula 15 also occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).", "Some methods further comprise the steps of: x) reacting a compound of Formula 12 with a reducing agent to generate a compound of Formula 13; and xiv) converting the compound of Formula 13 to the compound of Formula 15.In some implementations, the reducing agent of step x) comprises a chiral borane compound.", "And, in some examples, the chiral borane compound is selected from (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-1-butyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, (4S)-2-methyl-4,5,5-triphenyl-1,3,2-oxazaborolidine, or any combination thereof.", "Some methods further comprise the step of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises MnO2.Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11 In some implementations, the oxidizing agent of step i) comprises MnO2 or Dess-Martin periodinane.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the alkyllithium reagent of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having greater than about 99% e.e.", "; v) reacting the compound of Formula 1 with SiCl(R2)3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Some methods further comprise the steps of: xxii) reacting a compound of Formula 7 with a 3-haloprop-1-ene in the presence of a base and an organic solvent to generate a compound of Formula 8; and xxiii) deprotecting the compound of Formula 8 to generate the compound of Formula 9.Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xxii) reacting a compound of Formula 7, wherein R1 is C1-6 alkyl and each R2 is independently selected from C1-6 alkyl or phenyl, with a 3-haloprop-1-ene in the presence of a base and an organic solvent to generate a compound of xxiii) deprotecting the compound of Formula 8 to generate the compound of Formula 9, and xxiv) converting the compound of Formula 9 to the compound of Formula I, wherein the base of step xxii) comprises sec-butyl lithium.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein R1 is C1-6 alkyl and the oxidizing agent comprises MnO2 or Dess-Martin periodinane; ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a; and iii) converting the compound of Formula 11a to the compound of Formula I.", "In some implementations, the organic solvent of step i) comprises a halogenated organic solvent.", "For example, the organic solvent of step i) comprises dichloromethane, chloroform, or any combination thereof.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the base of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: viii) reacting a compound of Formula 11a with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 12a wherein R1 is C1-6 alkyl and the oxidizing agent comprises MnO2; and ix) converting the compound of Formula 12a to the compound of Formula I.", "In some implementations, the organic solvent of step viii) comprises a halogenated organic solvent.", "For example, the halogenated organic solvent of step viii) comprises dichloromethane, chloroform, or any combination thereof.", "Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein the oxidizing agent comprises MnO2 or Dess-Martin periodinane; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a.", "In some implementations, the organic solvent of step i) comprises a halogenated organic solvent.", "For example, the organic solvent of step i) comprises dichloromethane, chloroform, or any combination thereof.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the base of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: x) reacting a compound of Formula 12a with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13a wherein the organic solvent comprises THF, R1 is C1-6 alkyl, and each R2 is independently selected from C1-6 alkyl or phenyl; and xi) converting the compound of Formula 13 to the compound of Formula I.", "In some implementations, the reducing agent of step x) comprises a chiral borane compound.", "And, in some examples, the chiral borane compound is selected from (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-1-butyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, (4S)-2-methyl-4,5,5-triphenyl-1,3,2-oxazaborolidine, or any combination thereof.", "In some implementations, the organic solvent of step x) comprises THF.", "In some implementations, the organic solvent of step x) further comprises toluene.", "Some methods further comprise the step of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO2 Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a In some implementations, the oxidizing agent of step i) comprises MnO2 or Dess-Martin periodinane.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the alkyllithium reagent of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xii) hydrogenating a compound of Formula 15a in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a wherein R1 is C1-6 alkyl; and xiii) converting the compound of Formula 16a to the compound of Formula I.", "In some implementations, the hydrogenation of the compound of Formula 15a also occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).", "Some methods further comprise the steps of: x) reacting a compound of Formula 12a with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13a wherein the organic solvent comprises THF; and xiv) converting the compound of Formula 13a to the compound of Formula 15a.", "Some methods further comprise the steps of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO2 Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xv) reacting a compound of Formula 21a with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22a wherein R1 is C1-6 alkyl; and xvi) converting the compound of Formula 22a to the compound of Formula I.", "In some implementations, the transition metal catalyst of step xv) comprises a compound or complex either of which comprises Cu having a +1 oxidation state.", "For example, the transition metal catalyst of step xv) comprises CuX, wherein X is selected from halogen, acetate, benzoate, cyanide, hydroxide, nitrate, or any combination thereof.", "In other examples, the transition metal catalyst of step xv) comprises CuI.", "Some methods further comprise the steps of: xvii) reacting a compound of Formula 19a with triisopropylbenzenesulfonyl chloride under basic conditions to generate a compound of Formula 20a; and xviii) reacting the compound of Formula 20a with methanol under basic conditions to generate the compound of Formula 21a.", "Some methods further comprise the steps of: xix) reacting a compound of Formula 16a with a reducing agent to generate a compound of Formula 17a; xx) reacting the compound of Formula 17a with TBDPSCl under basic conditions to generate a compound of Formula 18a; and xxi) selectively deprotecting the compound of Formula 18a to generate the compound of Formula 19a.", "Some methods further comprise the step of: xii) hydrogenating a compound of Formula 15a in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a.", "In some implementations, the organic solvent of step xii) is anhydrous (e.g., anhydrous methanol or anhydrous THF).", "In some implementations, the hydrogenation of the compound of Formula 15a occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).", "Some methods further comprise the steps of: x) reacting a compound of Formula 12a with a reducing agent to generate a compound of Formula 13a; and xiv) converting the compound of Formula 13a to the compound of Formula 15a.", "Some methods further comprise the step of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO2.Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Some methods further comprise the steps of: xxii) reacting a compound of Formula 7a with a 3-haloprop-1-ene in the presence of a base and an organic solvent to generate a compound of Formula 8a; and xxiii) deprotecting the compound of Formula 8a to generate the compound of Formula 9.Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a; iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; vii) converting the compound of Formula 3a to the compound of Formula 5a; viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO2; x) reacting a compound of Formula 12a with a reducing agent to generate a compound of Formula 13a; xiv) converting the compound of Formula 13a to the compound of Formula 15a; xii) hydrogenating a compound of Formula 15a in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a; xix) reacting a compound of Formula 16a with a reducing agent to generate a compound of Formula 17a; xx) reacting the compound of Formula 17a with TDPSCl under basic conditions to generate a compound of Formula 18a; xxi) selectively deprotecting the compound of Formula 18a to generate the compound of Formula 19a; xvii) reacting a compound of Formula 19a with triisopropylbenzenesulfonyl chloride under basic conditions to generate a compound of Formula 20a; xviii) reacting the compound of Formula 20a with methanol under basic conditions to generate the compound of Formula 21a; xv) reacting a compound of Formula 21a with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22a; and xvi) converting the compound of Formula 22a to the compound of Formula I.", "Some methods further comprise the step of: xxiv) reacting the compound of Formula I with diethanolamine in the presence of an organic solvent to generate the diethanolamine salt of the compound of Formula I.", "Another aspect of the present invention provides a compound of Formula 21 wherein R1 is C1-6 alkyl and each R3 is independently C1-6 alkyl or phenyl.", "In some embodiments, R1 is methyl, ethyl, propyl, iso-propyl, butyl, sec-butyl, or tert-butyl.", "In other embodiments the —OSi(R3)3 group is selected from In some embodiments, R1 is methyl and the —OSi(R3)3 group is Another aspect of the present invention provides a compound of Formula 1a Another aspect of the present invention provides a method of purifying a compound of Formula 1 comprising the steps of: xxx) reacting a compound of Formula 1 with a derivatizing reagent to generate a precipitate that is substantially insoluble in dichloromethane or mixtures thereof (e.g., a mixture of dichloromethane and an alkane (e.g., heptane)); xxxi) collecting the precipitate and refluxing the precipitate in a solvent comprising an alcohol to generate the compound of Formula 1 having a chemical purity of about 98% or greater and an e.e.", "of about 98% or greater; wherein the method excludes the use of any column chromatography.", "In some implementations, the derivitizing reagent comprises 3,5-dinitrobenzoyl chloride and the alcohol comprises methanol.", "Another aspect of the present invention provides a method of purifying a compound of Formula 9 comprising the steps of: xl) reacting a compound of Formula 9, wherein R1 is C1-6 alkyl, with 3,5-dinitrobenzoyl chloride to generate a precipitate comprising a compound of Formula 9A; and xli) collecting the precipitate and treating the precipitate with a base in the presence of an alcohol to generate the compound of Formula 9 having a chemical purity of about 95% or greater (e.g., about 98% or greater, or from about 95% to about 99.9%); wherein the method excludes the use of any column chromatography.", "Some methods further comprise the step of: xlii) recrystallizing the precipitate of step xli).", "Another aspect of the present invention provides a method of generating a compound of Formula 5 wherein each of R2 is independently selected from a C1-6 alkyl or phenyl, comprising the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R2)3, wherein each R2 is independently selected from C1-6 alkyl or phenyl, under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; l) deprotecting the compound Formula 3 under basic condition to generate a compound of Formula 4, wherein each of R4 and R5 are H or —OSi(R2)3; and li) reacting the compound of Formula 4 with SiCl(R2)3 under basic conditions to generate the compound of Formula 5, wherein the compound of Formula 5 has a chemical purity of about 98% or greater and an e.e.", "of about 98% or greater (e.g., from about 99% to about 99.99%).", "Another aspect of the present invention provides a method of generating a compound of Formula 13 wherein R1 is C1-6 alkyl and each R2 is independently selected from C1-6 alkyl or phenyl, comprising the step of: x) reacting a compound of Formula 12 with (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole in the presence of an organic solvent comprising THF and toluene to generate a compound of Formula 13 wherein the compound of Formula 13 has a chemical purity of about 97% or greater and a d.e.", "of about 97% or greater.", "DETAILED DESCRIPTION OF THE INVENTION The present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof.", "The present invention also provides novel intermediates that are useful for the synthesis of the compound of Formula I. I. Definitions As used herein, the following definitions shall apply unless otherwise indicated.", "For purposes of this invention, the chemical elements are identified in accordance with the Periodic Table of the Elements, CAS version, Handbook of Chemistry and Physics, 75th Ed.", "Additionally, general principles of organic chemistry are described in “Organic Chemistry”, Thomas Sorrell, University Science Books, Sausalito: 1999, and “March's Advanced Organic Chemistry”, 5th Ed., Ed.", ": Smith, M. B. and March, J., John Wiley & Sons, New York: 2001, the entire contents of which are hereby incorporated by reference.", "As used herein, the term “Treprostinil” refers to (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3 S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid having the chemical structure, illustrated below, of the compound of Formula I Treprostinil is a synthetic analog of prostacyclin (PGI2) that is indicated for the treatment of pulmonary arterial hypertension and other diseases in patients.", "Treprostinil is formulated into a variety of dosage forms including forms suited for i.v.", "infusion and inhalation.", "As described herein, compounds of the invention may optionally be substituted with one or more substituents, such as are illustrated generally above, or as exemplified by particular classes, subclasses, and species of the invention.", "As used herein, the term “hydroxyl” or “hydroxy” refers to an —OH moiety.", "As used herein the term “aliphatic” encompasses the terms alkyl, alkenyl, alkynyl, each of which being optionally substituted as set forth below.", "As used herein, an “alkyl” group refers to a saturated aliphatic hydrocarbon group containing 1-12 (e.g., 1-8, 1-6, or 1-4) carbon atoms.", "An alkyl group can be straight or branched.", "Examples of alkyl groups include, but are not limited to, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, n-heptyl, or 2-ethylhexyl.", "An alkyl group can be substituted (i.e., optionally substituted) with one or more substituents such as halo, phospho, cycloaliphatic [e.g., cycloalkyl or cycloalkenyl], heterocycloaliphatic [e.g., heterocycloalkyl or heterocycloalkenyl], aryl, heteroaryl, alkoxy, aroyl, heteroaroyl, acyl [e.g., (aliphatic)carbonyl, (cycloaliphatic)carbonyl, or (heterocycloaliphatic)carbonyl], nitro, cyano, amido [e.g., (cycloalkylalkyl)carbonylamino, arylcarbonylamino, aralkyl carbonylamino, (heterocycloalkyl)carbonylamino, (heterocycloalkylalkyl)carbonylamino, heteroarylcarbonylamino, heteroaralkylcarbonylamino alkylaminocarbonyl, cycloalkylaminocarbonyl, heterocycloalkylaminocarbonyl, arylaminocarbonyl, or heteroarylaminocarbonyl], amino [e.g., aliphaticamino, cycloaliphaticamino, or heterocycloaliphaticamino], sulfonyl [e.g., aliphatic-SO2—], sulfinyl, sulfanyl, sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, carboxy, carbamoyl, cycloaliphaticoxy, heterocycloaliphaticoxy, aryloxy, heteroaryloxy, aralkyloxy, heteroarylalkoxy, alkoxycarbonyl, alkylcarbonyloxy, or hydroxy.", "Without limitation, some examples of substituted alkyls include carboxyalkyl (such as HOOC-alkyl, alkoxycarbonylalkyl, and alkylcarbonyloxyalkyl), cyanoalkyl, hydroxyalkyl, alkoxyalkyl, acylalkyl, aralkyl, (alkoxyaryl)alkyl, (sulfonylamino)alkyl (such as (alkyl-SO2-amino)alkyl), aminoalkyl, amidoalkyl, (cycloaliphatic)alkyl, or haloalkyl.", "As used herein, an “alkenyl” group refers to an aliphatic carbon group that contains 2-8 (e.g., 2-12, 2-6, or 2-4) carbon atoms and at least one double bond.", "Like an alkyl group, an alkenyl group can be straight or branched.", "Examples of an alkenyl group include, but are not limited to allyl, 1- or 2-isopropenyl, 2-butenyl, and 2-hexenyl.", "An alkenyl group can be optionally substituted with one or more substituents such as halo, phospho, cycloaliphatic [e.g., cycloalkyl or cycloalkenyl], heterocycloaliphatic [e.g., heterocycloalkyl or heterocycloalkenyl], aryl, heteroaryl, alkoxy, aroyl, heteroaroyl, acyl [e.g., (aliphatic)carbonyl, (cycloaliphatic)carbonyl, or (heterocycloaliphatic)carbonyl], nitro, cyano, amido [e.g., (cycloalkylalkyl)carbonylamino, arylcarbonylamino, aralkyl carbonylamino, (heterocycloalkyl)carbonylamino, (heterocycloalkylalkyl)carbonylamino, heteroarylcarbonylamino, heteroaralkylcarbonylamino alkylaminocarbonyl, cycloalkylaminocarbonyl, heterocycloalkylaminocarbonyl, arylaminocarbonyl, or heteroarylaminocarbonyl], amino [e.g., aliphaticamino, cycloaliphaticamino, heterocycloaliphaticamino, or aliphaticsulfonylamino], sulfonyl [e.g., alkyl-SO2—, cycloaliphatic-SO2—, or aryl-SO2—], sulfinyl, sulfanyl, sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, carboxy, carbamoyl, cycloaliphaticoxy, heterocycloaliphaticoxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkoxy, alkoxycarbonyl, alkylcarbonyloxy, or hydroxy.", "Without limitation, some examples of substituted alkenyls include cyanoalkenyl, alkoxyalkenyl, acylalkenyl, hydroxyalkenyl, aralkenyl, (alkoxyaryl)alkenyl, (sulfonylamino)alkenyl (such as (alkyl-SO2-amino)alkenyl), aminoalkenyl, amidoalkenyl, (cycloaliphatic)alkenyl, or haloalkenyl.", "As used herein, an “alkynyl” group refers to an aliphatic carbon group that contains 2-8 (e.g., 2-12, 2-6, or 2-4) carbon atoms and has at least one triple bond.", "An alkynyl group can be straight or branched.", "Examples of an alkynyl group include, but are not limited to, propargyl and butynyl.", "An alkynyl group can be optionally substituted with one or more substituents such as aroyl, heteroaroyl, alkoxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, aralkyloxy, nitro, carboxy, cyano, halo, hydroxy, sulfo, mercapto, sulfanyl [e.g., aliphaticsulfanyl or cycloaliphaticsulfanyl], sulfinyl [e.g., aliphaticsulfinyl or cycloaliphaticsulfinyl], sulfonyl [e.g., aliphatic-SO2—, aliphaticamino-SO2—, or cycloaliphatic-SO2—], amido [e.g., aminocarbonyl, alkylaminocarbonyl, alkylcarbonylamino, cycloalkylaminocarbonyl, heterocycloalkylaminocarbonyl, cycloalkylcarbonyl amino, arylaminocarbonyl, arylcarbonylamino, aralkylcarbonylamino, (heterocycloalkyl)carbonylamino, (cycloalkylalkyl)carbonylamino, heteroaralkyl carbonyl amino, heteroarylcarbonylamino or heteroarylaminocarbonyl], urea, thiourea, sulfamoyl, sulfamide, alkoxycarbonyl, alkylcarbonyloxy, cycloaliphatic, heterocycloaliphatic, aryl, heteroaryl, acyl [e.g., (cycloaliphatic)carbonyl or (heterocycloaliphatic)carbonyl], amino [e.g., aliphaticamino], sulfoxy, oxo, carboxy, carbamoyl, (cycloaliphatic)oxy, (heterocycloaliphatic)oxy, or (heteroaryl)alkoxy.", "As used herein, an “amido” encompasses both “aminocarbonyl” and “carbonylamino”.", "These terms when used alone or in connection with another group refer to an amido group such as —N(RX)—C(O)—RY or —C(O)—N(RX)2, when used terminally, and —C(O)—N(RX)— or —N(RX)—C(O)— when used internally, wherein RX and RY can be aliphatic, cycloaliphatic, aryl, araliphatic, heterocycloaliphatic, heteroaryl or heteroaraliphatic.", "Examples of amido groups include alkylamido (such as alkylcarbonylamino or alkylaminocarbonyl), (heterocycloaliphatic)amido, (heteroaralkyl)amido, (heteroaryl)amido, (heterocycloalkyl)alkylamido, arylamido, aralkylamido, (cycloalkyl)alkylamido, or cycloalkylamido.", "As used herein, an “amino” group refers to —NRXRY wherein each of RX and RY is independently hydrogen, aliphatic, cycloaliphatic, (cycloaliphatic)aliphatic, aryl, araliphatic, heterocycloaliphatic, (heterocycloaliphatic)aliphatic, heteroaryl, carboxy, sulfanyl, sulfinyl, sulfonyl, (aliphatic)carbonyl, (cycloaliphatic)carbonyl, ((cycloaliphatic)aliphatic)carbonyl, arylcarbonyl, (araliphatic)carbonyl, (heterocycloaliphatic)carbonyl, ((heterocycloaliphatic)aliphatic)carbonyl, (heteroaryl)carbonyl, or (heteroaraliphatic)carbonyl, each of which being defined herein and being optionally substituted.", "Examples of amino groups include alkylamino, dialkylamino, or arylamino.", "When the term “amino” is not the terminal group (e.g., alkylcarbonylamino), it is represented by —NRX—, where RX has the same meaning as defined above.", "As used herein, an “aryl” group used alone or as part of a larger moiety as in “aralkyl”, “aralkoxy”, or “aryloxyalkyl” refers to monocyclic (e.g., phenyl); bicyclic (e.g., indenyl, naphthalenyl, tetrahydronaphthyl, tetrahydroindenyl); and tricyclic (e.g., fluorenyl tetrahydrofluorenyl, or tetrahydroanthracenyl, anthracenyl) ring systems in which the monocyclic ring system is aromatic or at least one of the rings in a bicyclic or tricyclic ring system is aromatic.", "The bicyclic and tricyclic groups include benzofused 2-3 membered carbocyclic rings.", "For example, a benzofused group includes phenyl fused with two or more C4-8 carbocyclic moieties.", "An aryl is optionally substituted with one or more substituents including aliphatic [e.g., alkyl, alkenyl, or alkynyl]; cycloaliphatic; (cycloaliphatic)aliphatic; heterocycloaliphatic; (heterocycloaliphatic)aliphatic; aryl; heteroaryl; alkoxy; (cycloaliphatic)oxy; (heterocycloaliphatic)oxy; aryloxy; heteroaryloxy; (araliphatic)oxy; (heteroaraliphatic)oxy; aroyl; heteroaroyl; amino; oxo (on a non-aromatic carbocyclic ring of a benzofused bicyclic or tricyclic aryl); nitro; carboxy; amido; acyl [e.g., (aliphatic)carbonyl; (cycloaliphatic)carbonyl; ((cycloaliphatic)aliphatic)carbonyl; (araliphatic)carbonyl; (heterocycloaliphatic)carbonyl; ((heterocycloaliphatic)aliphatic)carbonyl; or (heteroaraliphatic)carbonyl]; sulfonyl [e.g., aliphatic-SO2— or amino-SO2—]; sulfinyl [e.g., aliphatic-S(O)— or cycloaliphatic-S(O)—]; sulfanyl [e.g., aliphatic-S—]; cyano; halo; hydroxy; mercapto; sulfoxy; urea; thiourea; sulfamoyl; sulfamide; or carbamoyl.", "Alternatively, an aryl can be unsubstituted.", "Non-limiting examples of substituted aryls include haloaryl [e.g., mono-, di (such as p,m-dihaloaryl), and (trihalo)aryl]; (carboxy)aryl [e.g., (alkoxycarbonyl)aryl, ((aralkyl)carbonyloxy)aryl, and (alkoxycarbonyl)aryl]; (amido)aryl [e.g., (aminocarbonyl)aryl, (((alkylamino)alkyl)aminocarbonyl)aryl, (alkylcarbonyl)aminoaryl, (arylaminocarbonyl)aryl, and (((heteroaryl)amino)carbonyl)aryl]; aminoaryl [e.g., ((alkylsulfonyl)amino)aryl or ((dialkyl)amino)aryl]; (cyanoalkyl)aryl; (alkoxy)aryl; (sulfamoyl)aryl [e.g., (aminosulfonyl)aryl]; (alkylsulfonyl)aryl; (cyano)aryl; (hydroxyalkyl)aryl; ((alkoxy)alkyl)aryl; (hydroxy)aryl, ((carboxy)alkyl)aryl; (((dialkyl)amino)alkyl)aryl; (nitroalkyl)aryl; (((alkylsulfonyl)amino)alkyl)aryl; ((heterocycloaliphatic)carbonyl)aryl; ((alkylsulfonyl)alkyl)aryl; (cyanoalkyl)aryl; (hydroxyalkyl)aryl; (alkylcarbonyl)aryl; alkylaryl; (trihaloalkyl)aryl; p-amino-m-alkoxycarbonylaryl; p-amino-m-cyanoaryl; p-halo-m-aminoaryl; or (m-(heterocycloaliphatic)-o-(alkyl))aryl.", "As used herein, an “araliphatic” such as an “aralkyl” group refers to an aliphatic group (e.g., a C1-4 alkyl group) that is substituted with an aryl group.", "“Aliphatic,” “alkyl,” and “aryl” are defined herein.", "An example of an araliphatic such as an aralkyl group is benzyl.", "As used herein, an “aralkyl” group refers to an alkyl group (e.g., a C1-4 alkyl group) that is substituted with an aryl group.", "Both “alkyl” and “aryl” have been defined above.", "An example of an aralkyl group is benzyl.", "An aralkyl is optionally substituted with one or more substituents such as aliphatic [e.g., alkyl, alkenyl, or alkynyl, including carboxyalkyl, hydroxyalkyl, or haloalkyl such as trifluoromethyl], cycloaliphatic [e.g., cycloalkyl or cycloalkenyl], (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, aryl, heteroaryl, alkoxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, aroyl, heteroaroyl, nitro, carboxy, alkoxycarbonyl, alkylcarbonyloxy, amido [e.g., aminocarbonyl, alkylcarbonylamino, cycloalkylcarbonyl amino, (cycloalkylalkyl)carbonyl amino, aryl carbonyl amino, aralkylcarbonylamino, (heterocycloalkyl)carbonylamino, (heterocycloalkyl alkyl)carbonyl amino, heteroarylcarbonylamino, or heteroaralkylcarbonylamino], cyano, halo, hydroxy, acyl, mercapto, alkylsulfanyl, sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, or carbamoyl.", "As used herein, a “bicyclic ring system” includes 6-12 (e.g., 8-12 or 9, 10, or 11) membered structures that form two rings, wherein the two rings have at least one atom in common (e.g., 2 atoms in common).", "Bicyclic ring systems include bicycloaliphatics (e.g., bicycloalkyl or bicycloalkenyl), bicycloheteroaliphatics, bicyclic aryls, and bicyclic heteroaryls.", "As used herein, a “cycloaliphatic” group encompasses a “cycloalkyl” group and a “cycloalkenyl” group, each of which being optionally substituted as set forth below.", "As used herein, a “cycloalkyl” group refers to a saturated carbocyclic mono- or bicyclic (fused or bridged) ring of 3-10 (e.g., 5-10) carbon atoms.", "Examples of cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, adamantyl, norbornyl, cubyl, octahydro-indenyl, decahydro-naphthyl, bicyclo[3.2.1]octyl, bicyclo[2.2.2]octyl, bicyclo[3.3.1]nonyl, bicyclo[3.3.2.", "]decyl, bicyclo[2.2.2]octyl, adamantyl, or ((aminocarbonyl)cycloalkyl)cycloalkyl.", "A “cycloalkenyl” group, as used herein, refers to a non-aromatic carbocyclic ring of 3-10 (e.g., 4-8) carbon atoms having one or more double bonds.", "Examples of cycloalkenyl groups include cyclopentenyl, 1,4-cyclohexa-di-enyl, cycloheptenyl, cyclooctenyl, hexahydro-indenyl, octahydro-naphthyl, cyclohexenyl, bicyclo[2.2.2]octenyl, or bicyclo[3.3.1]nonenyl.", "A cycloalkyl or cycloalkenyl group can be optionally substituted with one or more substituents such as phospho, aliphatic [e.g., alkyl, alkenyl, or alkynyl], cycloaliphatic, (cycloaliphatic) aliphatic, heterocycloaliphatic, (heterocycloaliphatic) aliphatic, aryl, heteroaryl, alkoxy, (cycloaliphatic)oxy, (heterocycloaliphatic)oxy, aryloxy, heteroaryloxy, (araliphatic)oxy, (heteroaraliphatic)oxy, aroyl, heteroaroyl, amino, amido [e.g., (aliphatic)carbonylamino, (cycloaliphatic)carbonyl amino, ((cycloaliphatic)aliphatic)carbonylamino, (aryl)carbonyl amino, (araliphatic)carbonylamino, (heterocycloaliphatic)carbonyl amino, ((heterocycloaliphatic)aliphatic)carbonylamino, (heteroaryl)carbonylamino, or (heteroaraliphatic)carbonyl amino], nitro, carboxy [e.g., HOOC—, alkoxycarbonyl, or alkylcarbonyloxy], acyl [e.g., (cycloaliphatic)carbonyl, ((cycloaliphatic) aliphatic)carbonyl, (araliphatic)carbonyl, (heterocycloaliphatic)carbonyl, ((heterocycloaliphatic)aliphatic)carbonyl, or (heteroaraliphatic)carbonyl], cyano, halo, hydroxy, mercapto, sulfonyl [e.g., alkyl-SO2— and aryl-SO2—], sulfinyl [e.g., alkyl-S(O)—], sulfanyl [e.g., alkyl-S—], sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, or carbamoyl.", "As used herein, the term “heterocycloaliphatic” encompasses heterocycloalkyl groups and heterocycloalkenyl groups, each of which being optionally substituted as set forth below.", "As used herein, a “heterocycloalkyl” group refers to a 3-10 membered mono- or bicylic (fused or bridged) (e.g., 5- to 10-membered mono- or bicyclic) saturated ring structure, in which one or more of the ring atoms is a heteroatom (e.g., N, O, S, or combinations thereof).", "Examples of a heterocycloalkyl group include piperidyl, piperazyl, tetrahydropyranyl, tetrahydrofuryl, 1,4-dioxolanyl, 1,4-dithianyl, 1,3-dioxolanyl, oxazolidyl, isoxazolidyl, morpholinyl, thiomorpholyl, octahydrobenzofuryl, octahydrochromenyl, octahydrothiochromenyl, octahydroindolyl, octahydropyrindinyl, decahydroquinolinyl, octahydrobenzo[b]thiopheneyl, 2-oxa-bicyclo[2.2.2]octyl, 1-aza-bicyclo[2.2.2]octyl, 3-aza-bicyclo[3.2.1]octyl, and 2,6-dioxa-tricyclo[3.3.1.03,7]nonyl.", "A monocyclic heterocycloalkyl group can be fused with a phenyl moiety to form structures, such as tetrahydroisoquinoline, which would be categorized as heteroaryls.", "A “heterocycloalkenyl” group, as used herein, refers to a mono- or bicylic (e.g., 5- to 10-membered mono- or bicyclic) non-aromatic ring structure having one or more double bonds, and wherein one or more of the ring atoms is a heteroatom (e.g., N, O, or S).", "Monocyclic and bicyclic heterocycloaliphatics are numbered according to standard chemical nomenclature.", "A heterocycloalkyl or heterocycloalkenyl group can be optionally substituted with one or more substituents such as phospho, aliphatic [e.g., alkyl, alkenyl, or alkynyl], cycloaliphatic, (cycloaliphatic)aliphatic, heterocycloaliphatic, (heterocycloaliphatic)aliphatic, aryl, heteroaryl, alkoxy, (cycloaliphatic)oxy, (heterocycloaliphatic)oxy, aryloxy, heteroaryloxy, (araliphatic)oxy, (heteroaraliphatic)oxy, aroyl, heteroaroyl, amino, amido [e.g., (aliphatic)carbonylamino, (cycloaliphatic)carbonylamino, ((cycloaliphatic) aliphatic)carbonyl amino, (aryl)carbonylamino, (araliphatic)carbonylamino, (heterocycloaliphatic)carbonyl amino, ((heterocycloaliphatic) aliphatic)carbonylamino, (heteroaryl)carbonylamino, or (heteroaraliphatic)carbonylamino], nitro, carboxy [e.g., HOOC—, alkoxycarbonyl, or alkylcarbonyloxy], acyl [e.g., (cycloaliphatic)carbonyl, ((cycloaliphatic) aliphatic)carbonyl, (araliphatic)carbonyl, (heterocycloaliphatic)carbonyl, ((heterocycloaliphatic)aliphatic)carbonyl, or (heteroaraliphatic)carbonyl], nitro, cyano, halo, hydroxy, mercapto, sulfonyl [e.g., alkylsulfonyl or arylsulfonyl], sulfinyl [e.g., alkylsulfinyl], sulfanyl [e.g., alkylsulfanyl], sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, or carbamoyl.", "A “heteroaryl” group, as used herein, refers to a monocyclic, bicyclic, or tricyclic ring system having 4 to 15 ring atoms wherein one or more of the ring atoms is a heteroatom (e.g., N, O, S, or combinations thereof) and in which the monocyclic ring system is aromatic or at least one of the rings in the bicyclic or tricyclic ring systems is aromatic.", "A heteroaryl group includes a benzofused ring system having 2 to 3 rings.", "For example, a benzofused group includes benzo fused with one or two 4 to 8 membered heterocycloaliphatic moieties (e.g., indolizyl, indolyl, isoindolyl, 3H-indolyl, indolinyl, benzo[b]furyl, benzo[b]thiophene-yl, quinolinyl, or isoquinolinyl).", "Some examples of heteroaryl are azetidinyl, pyridyl, 1H-indazolyl, furyl, pyrrolyl, thienyl, thiazolyl, oxazolyl, imidazolyl, tetrazolyl, benzofuryl, isoquinolinyl, benzthiazolyl, xanthene, thioxanthene, phenothiazine, dihydroindole, benzo[1,3]dioxole, benzo[b]furyl, benzo[b]thiophenyl, indazolyl, benzimidazolyl, benzthiazolyl, puryl, cinnolyl, quinolyl, quinazolyl, cinnolyl, phthalazyl, quinazolyl, quinoxalyl, isoquinolyl, 4H-quinolizyl, benzo-1,2,5-thiadiazolyl, or 1,8-naphthyridyl.", "Without limitation, monocyclic heteroaryls include furyl, thiophene-yl, 2H-pyrrolyl, pyrrolyl, oxazolyl, thazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, 1,3,4-thiadiazolyl, 2H-pyranyl, 4-H-pranyl, pyridyl, pyridazyl, pyrimidyl, pyrazolyl, pyrazyl, or 1,3,5-triazyl.", "Monocyclic heteroaryls are numbered according to standard chemical nomenclature.", "Without limitation, bicyclic heteroaryls include indolizyl, indolyl, isoindolyl, 3H-indolyl, indolinyl, benzo[b]furyl, benzo[b]thiophenyl, quinolinyl, isoquinolinyl, indolizyl, isoindolyl, indolyl, benzo[b]furyl, bexo[b]thiophenyl, indazolyl, benzimidazyl, benzthiazolyl, purinyl, 4H-quinolizyl, quinolyl, isoquinolyl, cinnolyl, phthalazyl, quinazolyl, quinoxalyl, 1,8-naphthyridyl, or pteridyl.", "Bicyclic heteroaryls are numbered according to standard chemical nomenclature.", "A heteroaryl is optionally substituted with one or more substituents such as aliphatic [e.g., alkyl, alkenyl, or alkynyl]; cycloaliphatic; (cycloaliphatic)aliphatic; heterocycloaliphatic; (heterocycloaliphatic)aliphatic; aryl; heteroaryl; alkoxy; (cycloaliphatic)oxy; (heterocycloaliphatic)oxy; aryloxy; heteroaryloxy; (araliphatic)oxy; (heteroaraliphatic)oxy; aroyl; heteroaroyl; amino; oxo (on a non-aromatic carbocyclic or heterocyclic ring of a bicyclic or tricyclic heteroaryl); carboxy; amido; acyl [e.g., aliphaticcarbonyl; (cycloaliphatic)carbonyl; ((cycloaliphatic)aliphatic)carbonyl; (araliphatic)carbonyl; (heterocycloaliphatic)carbonyl; ((heterocycloaliphatic)aliphatic)carbonyl; or (heteroaraliphatic)carbonyl]; sulfonyl [e.g., aliphaticsulfonyl or aminosulfonyl]; sulfinyl [e.g., aliphaticsulfinyl]; sulfanyl [e.g., aliphaticsulfanyl]; nitro; cyano; halo; hydroxy; mercapto; sulfoxy; urea; thiourea; sulfamoyl; sulfamide; or carbamoyl.", "Alternatively, a heteroaryl can be unsubstituted.", "Non-limiting examples of substituted heteroaryls include (halo)heteroaryl [e.g., mono- and di-(halo)heteroaryl]; (carboxy)heteroaryl [e.g., (alkoxycarbonyl)heteroaryl]; cyanoheteroaryl; aminoheteroaryl [e.g., ((alkylsulfonyl)amino)heteroaryl and ((dialkyl)amino)heteroaryl]; (amido)heteroaryl [e.g., aminocarbonylheteroaryl, ((alkylcarbonyl)amino)heteroaryl, ((((alkyl)amino)alkyl)aminocarbonyl)heteroaryl, (((heteroaryl)amino)carbonyl)heteroaryl, ((heterocycloaliphatic)carbonyl)heteroaryl, and ((alkylcarbonyl)amino)heteroaryl]; (cyanoalkyl)heteroaryl; (alkoxy)heteroaryl; (sulfamoyl)heteroaryl [e.g., (aminosulfonyl)heteroaryl]; (sulfonyl)heteroaryl [e.g., (alkylsulfonyl)heteroaryl]; (hydroxyalkyl)heteroaryl; (alkoxyalkyl)heteroaryl; (hydroxy)heteroaryl; ((carboxy)alkyl)heteroaryl; (((dialkyl)amino)alkyl]heteroaryl; (heterocycloaliphatic)heteroaryl; (cycloaliphatic)heteroaryl; (nitroalkyl)heteroaryl; (((alkylsulfonyl)amino)alkyl)heteroaryl; ((alkylsulfonyl)alkyl)heteroaryl; (cyanoalkyl)heteroaryl; (acyl)heteroaryl [e.g., (alkylcarbonyl)heteroaryl]; (alkyl)heteroaryl; or (haloalkyl)heteroaryl [e.g., trihaloalkylheteroaryl].", "A “heteroaraliphatic (such as a heteroaralkyl group) as used herein, refers to an aliphatic group (e.g., a C1-4 alkyl group) that is substituted with a heteroaryl group.", "“Aliphatic,” “alkyl,” and “heteroaryl” have been defined above.", "A “heteroaralkyl” group, as used herein, refers to an alkyl group (e.g., a C1-4 alkyl group) that is substituted with a heteroaryl group.", "Both “alkyl” and “heteroaryl” have been defined above.", "A heteroaralkyl is optionally substituted with one or more substituents such as alkyl (including carboxyalkyl, hydroxyalkyl, and haloalkyl such as trifluoromethyl), alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, aryl, heteroaryl, alkoxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, aroyl, heteroaroyl, nitro, carboxy, alkoxycarbonyl, alkylcarbonyloxy, aminocarbonyl, alkylcarbonylamino, cycloalkylcarbonyl amino, (cycloalkylalkyl)carbonyl amino, aryl carbonyl amino, aralkylcarbonylamino, (heterocycloalkyl)carbonylamino, (heterocycloalkyl alkyl)carbonyl amino, heteroarylcarbonylamino, heteroaralkylcarbonylamino, cyano, halo, hydroxy, acyl, mercapto, alkylsulfanyl, sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, or carbamoyl.", "As used herein, “cyclic moiety” and “cyclic group” refer to mono-, bi-, and tri-cyclic ring systems including cycloaliphatic, heterocycloaliphatic, aryl, or heteroaryl, each of which has been previously defined.", "As used herein, a “bridged bicyclic ring system” refers to a bicyclic heterocyclicalipahtic ring system or bicyclic cycloaliphatic ring system in which the rings are bridged.", "Examples of bridged bicyclic ring systems include, but are not limited to, adamantanyl, norbornanyl, bicyclo[3.2.1]octyl, bicyclo[2.2.2]octyl, bicyclo[3.3.1]nonyl, bicyclo[3.3.2]decyl, 2-oxabicyclo[2.2.2]octyl, 1-azabicyclo[2.2.2]octyl, 3-azabicyclo[3.2.1]octyl, and 2,6-dioxa-tricyclo[3.3.1.03,7]nonyl.", "A bridged bicyclic ring system can be optionally substituted with one or more substituents such as alkyl (including carboxyalkyl, hydroxyalkyl, and haloalkyl such as trifluoromethyl), alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, aryl, heteroaryl, alkoxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, aroyl, heteroaroyl, nitro, carboxy, alkoxycarbonyl, alkylcarbonyloxy, aminocarbonyl, alkylcarbonylamino, cycloalkylcarbonyl amino, (cycloalkylalkyl)carbonyl amino, aryl carbonyl amino, aralkylcarbonylamino, (heterocycloalkyl)carbonylamino, (heterocycloalkyl alkyl)carbonyl amino, heteroarylcarbonylamino, heteroaralkylcarbonylamino, cyano, halo, hydroxy, acyl, mercapto, alkylsulfanyl, sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, or carbamoyl.", "As used herein, an “acyl” group refers to a formyl group or RX—C(O)— (such as alkyl-C(O)—, also referred to as “alkylcarbonyl”) where RX and “alkyl” have been defined previously.", "Acetyl and pivaloyl are examples of acyl groups.", "As used herein, an “aroyl” or “heteroaroyl” refers to an aryl-C(O)— or a heteroaryl-C(O)—.", "The aryl and heteroaryl portion of the aroyl or heteroaroyl is optionally substituted as previously defined.", "As used herein, an “alkoxy” group refers to an alkyl-O— group where “alkyl” has been defined previously.", "As used herein, a “carbamoyl” group refers to a group having the structure —O—CO—NRXRY or —NRX—CO—O—RZ, wherein RX and RY have been defined above and RZ can be aliphatic, aryl, araliphatic, heterocycloaliphatic, heteroaryl, or heteroaraliphatic.", "As used herein, a “carboxy” group refers to —COOH, —COORX, —OC(O)H, —OC(O)RX, when used as a terminal group; or —OC(O)— or —C(O)O— when used as an internal group.", "As used herein, a “haloaliphatic” group refers to an aliphatic group substituted with 1-3 halogen.", "For instance, the term haloalkyl includes the group —CF3.As used herein, a “mercapto” group refers to —SH.", "As used herein, a “sulfo” group refers to —SO3H or —SO3RX when used terminally or —S(O)3— when used internally.", "As used herein, a “sulfamide” group refers to the structure —NRX—S(O)2—NRYRZ when used terminally and —NRX—S(O)2—NRY— when used internally, wherein RX, RY, and RZ have been defined above.", "As used herein, a “sulfamoyl” group refers to the structure —O—S(O)2—NRYRZ wherein RY and RZ have been defined above.", "As used herein, a “sulfonamide” group refers to the structure —S(O)2—NRXRY or —NRX—S(O)2—RZ when used terminally; or —S(O)2—NRX— or —NRX—S(O)2— when used internally, wherein RX, RY, and RZ are defined above.", "As used herein a “sulfanyl” group refers to —S—RX when used terminally and —S— when used internally, wherein RX has been defined above.", "Examples of sulfanyls include aliphatic-S—, cycloaliphatic-S—, aryl-S—, or the like.", "As used herein a “sulfinyl” group refers to —S(O)—RX when used terminally and —S(O)— when used internally, wherein RX has been defined above.", "Exemplary sulfinyl groups include aliphatic-S(O)—, aryl-S(O)—, (cycloaliphatic(aliphatic))-S(O)—, cycloalkyl-S(O)—, heterocycloaliphatic-S(O)—, heteroaryl-S(O)—, or the like.", "As used herein, a “sulfonyl” group refers to —S(O)2—RX when used terminally and —S(O)2— when used internally, wherein RX has been defined above.", "Exemplary sulfonyl groups include aliphatic-S(O)2—, aryl-S(O)2—, (cycloaliphatic(aliphatic))-S(O)2—, cycloaliphatic-S(O)2—, heterocycloaliphatic-S(O)2—, heteroaryl-S(O)2—, (cycloaliphatic(amido(aliphatic)))-S(O)2— or the like.", "As used herein, a “sulfoxy” group refers to —O—S(O)—RX or —S(O)—O—RX, when used terminally and —O—S(O)— or —S(O)—O— when used internally, where RX has been defined above.", "As used herein, a “halogen” or “halo” group refers to fluorine, chlorine, bromine or iodine.", "As used herein, an “alkoxycarbonyl,” which is encompassed by the term carboxy, used alone or in connection with another group refers to a group such as alkyl-O—C(O)—.", "As used herein, an “alkoxyalkyl” refers to an alkyl group such as alkyl-O-alkyl-, wherein alkyl has been defined above.", "As used herein, a “carbonyl” refers to —C(O)—.", "As used herein, an “oxo” refers to ═O.", "As used herein, the term “phospho” refers to phosphinates and phosphonates.", "Examples of phosphinates and phosphonates include —P(O)(RP)2, wherein RP is aliphatic, alkoxy, aryloxy, heteroaryloxy, (cycloaliphatic)oxy, (heterocycloaliphatic)oxy aryl, heteroaryl, cycloaliphatic or amino.", "As used herein, an “aminoalkyl” refers to the structure (RX)2N-alkyl-.", "As used herein, a “cyanoalkyl” refers to the structure (NC)-alkyl-.", "As used herein, a “urea” group refers to the structure —NRX—CO—NRYRZ and a “thiourea” group refers to the structure —NRX—CS—NRYRZ when used terminally and —NRX—CO—NRY— or —NRX—CS—NRY— when used internally, wherein Rx, RY, and RZ have been defined above.", "As used herein, a “guanidine” group refers to the structure —N═C(N(RXRY))N(RXRY) or —NRX—C(═NRX)NRXRY wherein RX and RY have been defined above.", "As used herein, the term “amidino” group refers to the structure —C═(NRX)N(RXRY) wherein RX and RY have been defined above.", "In general, the term “vicinal” refers to the placement of substituents on a group that includes two or more carbon atoms, wherein the substituents are attached to adjacent carbon atoms.", "In general, the term “geminal” refers to the placement of substituents on a group that includes two or more carbon atoms, wherein the substituents are attached to the same carbon atom.", "The terms “terminally” and “internally” refer to the location of a group within a substituent.", "A group is terminal when the group is present at the end of the substituent not further bonded to the rest of the chemical structure.", "Carboxyalkyl, i.e., RXO(O)C-alkyl is an example of a carboxy group used terminally.", "A group is internal when the group is present in the middle of a substituent of the chemical structure.", "Alkylcarboxy (e.g., alkyl-C(O)O— or alkyl-OC(O)—) and alkylcarboxyaryl (e.g., alkyl-C(O)O-aryl- or alkyl-O(CO)-aryl-) are examples of carboxy groups used internally.", "As used herein, an “aliphatic chain” refers to a branched or straight aliphatic group (e.g., alkyl groups, alkenyl groups, or alkynyl groups).", "A straight aliphatic chain has the structure —[CH2]v—, where v is 1-12.A branched aliphatic chain is a straight aliphatic chain that is substituted with one or more aliphatic groups.", "A branched aliphatic chain has the structure —[CQQ]v- where Q is independently a hydrogen or an aliphatic group; however, Q shall be an aliphatic group in at least one instance.", "The term aliphatic chain includes alkyl chains, alkenyl chains, and alkynyl chains, where alkyl, alkenyl, and alkynyl are defined above.", "As used herein, “Dess-Martin periodinane” and its abbreviation “DMP” are used interchangeably.", "DMP refers to 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one having the structure The phrase “optionally substituted” is used interchangeably with the phrase “substituted or unsubstituted.” As described herein, compounds of the invention can optionally be substituted with one or more substituents, such as are illustrated generally above, or as exemplified by particular classes, subclasses, and species of the invention.", "As described herein, the variables R1, R2, R3, R4, R10, and other variables contained in Formulae IA and I described herein encompass specific groups, such as alkyl and aryl.", "Unless otherwise noted, each of the specific groups for the variables R1, R2, R3, R4, R10, and other variables contained therein can be optionally substituted with one or more substituents described herein.", "Each substituent of a specific group is further optionally substituted with one to three of halo, cyano, oxo, alkoxy, hydroxy, amino, nitro, aryl, cycloaliphatic, heterocycloaliphatic, heteroaryl, haloalkyl, and alkyl.", "For instance, an alkyl group can be substituted with alkylsulfanyl and the alkylsulfanyl can be optionally substituted with one to three of halo, cyano, oxo, alkoxy, hydroxy, amino, nitro, aryl, haloalkyl, and alkyl.", "As an additional example, the cycloalkyl portion of a (cycloalkyl)carbonylamino can be optionally substituted with one to three of halo, cyano, alkoxy, hydroxy, nitro, haloalkyl, and alkyl.", "When two alkoxy groups are bound to the same atom or adjacent atoms, the two alkxoy groups can form a ring together with the atom(s) to which they are bound.", "In general, the term “substituted,” whether preceded by the term “optionally” or not, refers to the replacement of hydrogen atoms in a given structure with the radical of a specified substituent.", "Specific substituents are described above in the definitions and below in the description of compounds and examples thereof.", "Unless otherwise indicated, an optionally substituted group can have a substituent at each substitutable position of the group, and when more than one position in any given structure can be substituted with more than one substituent selected from a specified group, the substituent can be either the same or different at every position.", "A ring substituent, such as a heterocycloalkyl, can be bound to another ring, such as a cycloalkyl, to form a spiro-bicyclic ring system, e.g., both rings share one common atom.", "As one of ordinary skill in the art will recognize, combinations of substituents envisioned by this invention are those combinations that result in the formation of stable or chemically feasible compounds.", "The phrase “stable or chemically feasible,” as used herein, refers to compounds that are not substantially altered when subjected to conditions to allow for their production, detection, and preferably their recovery, purification, and use for one or more of the purposes disclosed herein.", "In some embodiments, a stable compound or chemically feasible compound is one that is not substantially altered when kept at a temperature of 40° C. or less, in the absence of moisture or other chemically reactive conditions, for at least a week.", "As used herein, “chemical purity” refers to the degree to which a substance, i.e., the desired product or intermediate, is undiluted or unmixed with extraneous material such as chemical byproducts.", "Unless otherwise stated, structures depicted herein are also meant to include all isomeric (e.g., enantiomeric, diastereomeric, and geometric (or conformational)) forms of the structure; for example, the R and S configurations for each asymmetric center, (Z) and (E) double bond isomers, and (Z) and (E) conformational isomers.", "Therefore, single stereochemical isomers as well as enantiomeric, diastereomeric, and geometric (or conformational) mixtures of the present compounds are within the scope of the invention.", "Unless otherwise stated, all tautomeric forms of the compounds of the invention are within the scope of the invention.", "Additionally, unless otherwise stated, structures depicted herein are also meant to include compounds that differ only in the presence of one or more isotopically enriched atoms.", "For example, compounds having the present structures except for the replacement of hydrogen by deuterium or tritium, or the replacement of a carbon by a 13C- or 14C-enriched carbon are within the scope of this invention.", "Such compounds are useful, for example, as analytical tools or probes in biological assays, or as therapeutic agents.", "Chemical structures and nomenclature are derived from ChemDraw, version 11.0.1, Cambridge, Mass.", "It is noted that the use of the descriptors “first”, “second”, “third”, or the like is used to differentiate separate elements (e.g., solvents, reaction steps, processes, reagents, or the like) and may or may not refer to the relative order or relative chronology of the elements described.", "II.", "Commonly Used Abbreviations The following abbreviations are used: PG protecting group LG leaving group DCM dichloromethane Ac acetyl THF tetrohydrofuran TMS trimethylsilyl TBS tert-butyldimethyl silyl TIPS tri-iso-propylsilyl TBDPS tert-butyldiphenylsilyl TOM tri-iso-propyl silyloxymethyl DMP Dess-Martin periodinane IBX 2-iodoxybenzoic acid DMF dimethylformamide MTBE methyl-tert-butylether TBAF tetra-n-butylammonium fluoride d.e.", "diastereomeric excess e.e.", "enantiomeric excess EtOAc ethyl acetate DMSO dimethyl sulfoxide MeCN acetonitrile TCA trichloroacetic acid ATP adenosine triphosphate EtOH ethanol Ph phenyl Me methyl Et ethyl Bu butyl iPr isopropyl tBu tertbutyl DEAD diethylazodicarboxylate HEPES 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid DTT dithiothreitol MOPS 4-morpholinepropanesulfonic acid NMR nuclear magnetic resonance HPLC high performance liquid chromatography LCMS liquid chromatography-mass spectrometry TLC thin layer chromatography Rt retention time HOBt hydroxybenzotriazole Ms mesyl Ts tosyl Tf triflyl Bs besyl Ns nosyl Cbz carboxybenzyl Moz p-methoxybenzyl carbonyl Boc tert-butyloxycarbonyl Fmoc 9-fluorenylmethyloxycarbonyl Bz benzoly Bn benzyl PMB p-methoxybenzyl DMPM 3,4-dimethoxybenzyl PMP p-methoxyphenyl III.", "Methods of Synthesis One aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein R1 is C1-6 alkyl and the oxidizing agent comprises MnO2 or Dess-Martin periodinane; ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11, wherein each R2 is independently selected from C1-6 alkyl or phenyl; and iii) converting the compound of Formula 11 to the compound of Formula I.", "A.", "Step i) Step i) comprises reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein R1 is C1-6 alkyl.", "In some implementations, R1 is methyl, ethyl, propyl, iso-propyl, butyl, sec-butyl, or tert-butyl.", "For example, R1 is methyl.", "In some implementations, the oxidizing agent of step i) comprises manganese(IV)oxide, i.e., MnO2, DMP, or IBX.", "For example, the oxidizing agent comprises MnO2 or DMP.", "And, in some instances, the oxidizing agent comprises MnO2.The organic solvent of step i) is any suitable solvent that is capable of substantially dissolving the compound of Formula 9 and is substantially inert when combined with the oxidizing agent and the compound of Formula 9.In some implementations, the organic solvent of step i) comprises a halogenated organic solvent.", "For example, the halogenated organic solvent comprises dichloromethane, i.e., methylene chloride, chloroform, or any combination thereof.", "In other implementations, the organic solvent (e.g., dichloromethane) is anhydrous.", "In some implementations, the reaction of step i) is performed at a temperature from about 10° C. to about 40° C. For example, the reaction of step i) is performed at room temperature.", "In other implementations, the reaction of step i) is performed under agitation, e.g., stirring.", "In some implementations, the reaction of step i) is performed under an inert gas (e.g., nitrogen gas).", "In other implementations, the reaction of step i) is about 99% complete (e.g., from about 95% to about 99.9% complete after about 15 hrs (e.g.", "from about 14 to about 18 hrs).", "In some implementations, step i) generates the compound of Formula 10, having a yield of greater than about 95% (e.g., from about 95% to about 99.9% or about 99%).", "B.", "Step ii) Step ii) comprises reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11, wherein each R2 is independently selected from C1-6 alkyl or phenyl.", "In some implementations, the base comprises an alkyllithium reagent.", "Examples of alkyllithium reagents include butyllithium, hexyllithium, sec-butyllithium, and methyllithium.", "In some instances, the base comprises sec-butyllithium.", "Organic solvents that are useful in the reaction of step ii) comprise alkanes, cyclic alkanes, heterocycles (e.g., THF, 1,4-dioxane, or any combination thereof), ethers, or any combination thereof.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, THF, 1,4-dioxane, diethyl ether, petro ether, MTBE, or any combination thereof.", "For example, the organic solvent of step ii) comprises MTBE.", "In other implementations, the organic solvent of step ii) is anhydrous (e.g., anhydrous MTBE).", "And, in some implementations, the base of step ii) comprises sec-butyllithium, and the organic solvent of step ii) comprises MTBE.", "In some implementations, the compound of Formula 5 has an e.e.", "of about 98% or greater (e.g., from about 98.0% to about 99.9%).", "In other implementations, the compound of Formula 5 has a chemical purity of about 95% or greater (e.g., from about 97% to about 99.9%).", "In some implementations, the reaction of step ii) is performed at a temperature from about −80° C. to about 30° C.", "(e.g., from about −78° C. to about room temperature).", "In other implementations, the reaction of step ii) is performed under agitation, e.g., stirring.", "In some implementations, the reaction of step ii) is performed under an inert gas (e.g., nitrogen gas).", "C. Additional Steps Steps iv)-vii) may optionally be performed with other steps described herein to generate the compound of Formula I.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R2)3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Step iv) is an efficient stereoselective method for generating the compound of Formula 1 having an e.e.", "of greater than 98% that does not require additional chromatography.", "Moreover, in some implementations, step iv) generates the compound of Formula 1 with a yield of at least about 90% (e.g., at least about 91%, or about 92%).", "In some implementations, the refluxing of the compound of Formula 1a occurs in the presence of an alcohol (e.g., methanol, ethanol, or any combination thereof).", "In other implementations, the compound of Formula 1a undergoes reflux in the presence of methanol (e.g., anhydrous methanol).", "In other implementations, the compound of Formula 1a is heated to reflux under an inert gas (e.g., nitrogen).", "And, in some implementations, the compound of Formula 1a is heated to reflux for a period of about 1 to about 3 hrs (e.g., about 2 hrs).", "Step v) comprises the protection of the hydroxy functional group of the compound of Formula 1 under basic conditions to generate the alkylsilyl ether compound of Formula 2.In some implementations, the base of step v) comprises a nitrogen base.", "In some examples, the nitrogen base comprises Et3N, imidazole, piperidine, piperazine, any combination thereof, or the like.", "For instance, the base of step v) comprises imidazole.", "In some implementations, the SiCl(R2)3 reagent of step v) comprises chloro-tert-butyldimethylsilane (TBS-Cl), tert-butylchlorodiphenyl silane (TBDPS-Cl), chlorotrimethylsilane (TMS-Cl), triisopropylsilyloxymethyl chloride (TOM-Cl), or chlorotriisopropylsilane (TIPS-Cl).", "In some implementations, the 1-TMS-1-propyne of step vi) is first reacted with an alkyllithium reagent followed by the reaction with the compound of Formula 2.The present invention provides a method of generating a compound of Formula 5 wherein each R2 is independently selected from a C1-6 alkyl or phenyl, comprising the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98% (e.g., greater than about 98.5%, greater than about 99% or from about 98.5% to about 99.9%); v) reacting the compound of Formula 1 with SiCl(R2)3, wherein each R2 is independently selected from C1-6 alkyl or phenyl, under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; l) deprotecting the compound Formula 3 under basic condition to generate a compound of Formula 4, wherein each of R4 and R5 are H or —OSi(R2)3; and li) reacting the compound of Formula 4 with SiCl(R2)3 under basic conditions to generate the compound of Formula 5, wherein the compound of Formula 5 has a chemical purity of about 98% or greater (e.g., greater than about 98.5%, greater than about 99% or from about 98.5% to about 99.9%) and an e.e.", "of about 98% or greater (e.g., from about 99% to about 99.99%).", "In implementations, the compound of Formula 5 has a chemical purity of about 95% or greater (e.g., from about 97% to about 99.9% or about 99% or greater) and an e.e.", "of about 98% or greater (e.g., about 99% or greater).", "In some implementations, the compound of Formula 5 has an e.e.", "of ˜100%, e.g., about 98% or greater, about 99% or greater, or greater than 99%.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: viii) reacting a compound of Formula 11 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 12 wherein R1 is C1-6 alkyl, each R2 is independently selected from C1-6 alkyl or phenyl, and the oxidizing agent comprises MnO2; and ix) converting the compound of Formula 12 to the compound of Formula I. D. Step viii) The reaction of step viii) accomplishes the oxidation of the compound of Formula 11 to generate the compound of Formula 12 using an oxidizing agent that possesses a reduced toxicity than traditional chromium based oxidation agents (e.g., PCC).", "In some implementations, each of the —OSi(R2)3 groups in the compounds of Formulae 11 and 12 is independently selected from In some implementations, the organic solvent of step viii) comprises a halogenated organic solvent.", "In some examples, the halogenated organic solvent of step viii) comprises dichloromethane, chloroform, or any combination thereof.", "In other examples, the organic solvent of step viii) (e.g., dichloromethane) is anhydrous.", "Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein R1 is C1-6 alkyl and the oxidizing agent comprises MnO2 or Dess-Martin periodinane; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11.Steps i) and ii) are described, in detail, above.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: x) reacting a compound of Formula 12 with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13 wherein the organic solvent comprises THF, R1 is C1-6 alkyl, and R2 is independently selected from C1-6 alkyl or phenyl; and xi) converting the compound of Formula 13 to the compound of Formula I. E. Step x) In some implementations, the reducing agent of step x) comprises a chiral borane compound.", "In some implementations, the chiral borane compound of step x) reacts with the compound of Formula 12 to generate the compound of Formula 13 with a d.e.", "of about 97% or greater (e.g., about 97.5% of greater).", "In other implementations, the chiral borane reducing agent is formed in situ or ex situ.", "And, in some examples, the chiral borane compound is selected from (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-1-butyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, (R)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, (4S)-2-methyl-4,5,5-triphenyl-1,3,2-oxazaborolidine, or any combination thereof.", "In some implementations, the organic solvent of step x) further comprises toluene.", "And, in some implementations, the organic solvent of step x) is anhydrous.", "Some methods further comprise the step of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11 Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R2)3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Each of steps i), ii), and iv)-viii) is discussed above.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xii) hydrogenating a compound of Formula 15 in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16 wherein R1 is C1-6 alkyl and each R2 is independently selected from C1-6 alkyl or phenyl; and xiii) converting the compound of Formula 16 to the compound of Formula I. F. Step xii) Step xii) comprises the improved hydrogenation of the compound of Formula 15 to generate the compound of Formula 16.Some implementations comprise the hydrogenation of the compound of Formula 15 in the presence of an alcohol (e.g., methanol or ethanol), optionally substituted THF (e.g., THF or 2-Me-THF), or any combination thereof to generate the compound of Formula 16.In other implementations, the hydrogenation of the compound of Formula 15 occurs in the presence of an alcohol (e.g., methanol or ethanol), optionally substituted THF (e.g., THF or 2-Me-THF), or any combination thereof and a base (e.g., potassium carbonate or potassium bicarbonate).", "The substitution of methanol for the traditional ethanol in step xii) produces an improved yield (e.g., at least about 88%) and improved chemical purity for the compound of Formula 16.Some methods further comprise the steps of: x) reacting a compound of Formula 12 with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13 wherein the organic solvent comprises THF; and xiv) converting the compound of Formula 13 to the compound of Formula 15.Some methods further comprise the steps of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises MnO2 Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11 In some implementations, the oxidizing agent of step i) comprises MnO2 or Dess-Martin periodinane.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R2)3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Each of steps i), ii), iv), v)-viii), x), and xiv) is discussed above.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xv) reacting a compound of Formula 21 with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22 wherein R3 is C1-6 alkyl or phenyl; and xvi) converting the compound of Formula 22 to the compound of Formula I. G. Step xv) Step xv) generates a yield of at least about 70% (e.g., at least about 75%, at least about 80%, or about 82%) for the compound of Formula 22.In some implementations, the reaction of step xv) is conducted at a temperature of from about −80° C. to about −20° C.", "(e.g., from about −78° C. to about −30° C.).", "In some implementations, the transition metal catalyst of step xv) comprises copper having a +1 oxidation state.", "For example, the transition metal catalyst comprises a copper compound or a copper complex wherein the Cu has a +1 oxidation state.", "In other examples, the transition metal catalyst of step xv) comprises CuX, wherein X is selected from halogen, acetate, benzoate, cyanide, hydroxide, nitrate, or any combination thereof.", "In other examples, the transition metal catalyst of step xv) comprises CuI.", "Some methods further comprise the steps of: xvii) reacting a compound of Formula 19 with R4-substituted benzenesulfonyl chloride under basic conditions to generate a compound of Formula 20, wherein each R4 is independently selected from —H or C1-3 alkyl; and xviii) reacting the compound of Formula 20 with methanol under basic conditions to generate the compound of Formula 21.In some implementations, the R4-substituted benzenesulfonyl chloride of step xvii) is 2-mesitylenesulfonyl chloride (2,4,6-trimethylbenzenesulfonyl chloride) or tosyl chloride (TsCl).", "Some methods further comprise the steps of: xix) reacting a compound of Formula 16 with a reducing agent to generate a compound of Formula 17; xx) reacting the compound of Formula 17 with Si(R3)3Cl under basic conditions to generate a compound of Formula 18; and xxi) selectively deprotecting the compound of Formula 18 to generate the compound of Formula 19.Some methods further comprise the steps of: xii) hydrogenating a compound of Formula 15 in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16.In some implementations, the hydrogenation of the compound of Formula 15 occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).", "Some methods further comprise the steps of: x) reacting a compound of Formula 12 with a reducing agent to generate a compound of Formula 13; and xiv) converting the compound of Formula 13 to the compound of Formula 15.Some methods further comprise the step of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises MnO2.Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11 Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having greater than about 99% e.e.", "; v) reacting the compound of Formula 1 with SiCl(R2)3 under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; and vii) converting the compound of Formula 3 to the compound of Formula 5.Steps i), ii), iv)-viii), x), xii), and xiv) are discussed above.", "The present invention also provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xxii) reacting a compound of Formula 7, wherein R1 is C1-6 alkyl and R2 is independently selected from C1-6 alkyl or phenyl, with a 3-haloprop-1-ene in the presence of a base and an organic solvent to generate a compound of Formula 8; xxiii) deprotecting the compound of Formula 8 to generate the compound of Formula 9, and xxiv) converting the compound of Formula 9 to the compound of Formula I, wherein the base of step xxii) comprises sec-butyl lithium.", "H. Step xxii) The reaction of step xxii) generates the compound of Formula 8 with improved chemical purity without additional chromatography steps.", "In some implementations, the reaction of step xxii) is conducted at room temperature (e.g., from about 20° C. to about 30° C.) for a period of about 2 hrs (e.g., from about 1.5 to about 2.5 hrs) then cooled to a temperature of about 0° C.", "(e.g., from about −5° C. to about 5° C.) under stirring.", "In some implementations, the organic solvent of step xxii) comprises one or more alkanes.", "For example, the organic solvent of step xxii) comprises heptanes, cyclohexane, or any combination thereof.", "In other implementations, the organic solvent of step xxii) comprises MTBE.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein R1 is C1-6 alkyl and the oxidizing agent comprises MnO2 or Dess-Martin periodinane; ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a; and iii) converting the compound of Formula 11a to the compound of Formula I.", "Steps i) and ii) are discussed in detail above.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: viii) reacting a compound of Formula 11a with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 12a wherein R1 is C1-6 alkyl and the oxidizing agent comprises MnO2; and ix) converting the compound of Formula 12a to the compound of Formula I.", "Step viii) is discussed above.", "Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10 wherein the oxidizing agent comprises MnO2 or Dess-Martin periodinane; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a.", "Steps i) and ii) are discussed in detail above.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: x) reacting a compound of Formula 12a with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13a wherein the organic solvent comprises THF, R1 is C1-6 alkyl, and each R2 is independently selected from C1-6 alkyl or phenyl; and xi) converting the compound of Formula 13 to the compound of Formula I.", "Steps x) and xi) are discusses in detail above.", "Some methods further comprise the step of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO2 Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a In some implementations, the oxidizing agent of step i) comprises MnO2 or Dess-Martin periodinane.", "In some implementations, the base of step ii) comprises an alkyllithium reagent.", "For example, the alkyllithium reagent of step ii) comprises sec-butyllithium.", "In some implementations, the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-tert-butylether, or any combination thereof.", "For example, the organic solvent of step ii) comprises methyl-tert-butylether.", "Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xii) hydrogenating a compound of Formula 15a in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a wherein R1 is C1-6 alkyl; and xiii) converting the compound of Formula 16a to the compound of Formula I.", "In some implementations, the hydrogenation of the compound of Formula 15a occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).", "Some methods further comprise the steps of: x) reacting a compound of Formula 12a with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13a wherein the organic solvent comprises THF; and xiv) converting the compound of Formula 13a to the compound of Formula 15a.", "Some methods further comprise the steps of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: xv) reacting a compound of Formula 21a with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22a wherein R1 is C1-6 alkyl; and xvi) converting the compound of Formula 22a to the compound of Formula I.", "In some implementations, the transition metal catalyst of step xv) comprises a compound or complex either of which comprises Cu having a +1 oxidation state.", "For example, the transition metal catalyst of step xv) comprises CuX, wherein X is selected from halogen, acetate, benzoate, cyanide, hydroxide, nitrate, or any combination thereof.", "In other examples, the transition metal catalyst of step xv) comprises CuI.", "Some methods further comprise the steps of: xvii) reacting a compound of Formula 19a with triisopropylbenzenesulfonyl chloride under basic conditions to generate a compound of Formula 20a; and xviii) reacting the compound of Formula 20a with methanol under basic conditions to generate the compound of Formula 21a.", "Some methods further comprise the steps of: xix) reacting a compound of Formula 16a with a reducing agent to generate a compound of Formula 17a; xx) reacting the compound of Formula 17a with TBDPSCl under basic conditions to generate a compound of Formula 18a; and xxi) selectively deprotecting the compound of Formula 18a to generate the compound of Formula 19a.", "Some methods further comprise the step of: xii) hydrogenating a compound of Formula 15a in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a.", "In some implementations, the hydrogenation of the compound of Formula 15a occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).", "Some methods further comprise the steps of: x) reacting a compound of Formula 12a with a reducing agent to generate a compound of Formula 13a; and xiv) converting the compound of Formula 13a to the compound of Formula 15a.", "Some methods further comprise the step of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO2.Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a Some methods further comprise the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.", "Some methods further comprise the steps of: xxii) reacting a compound of Formula 7a with a 3-haloprop-1-ene in the presence of a base and an organic solvent to generate a compound of Formula 8a; and xxiii) deprotecting the compound of Formula 8a to generate the compound of Formula 9.Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a; iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; vii) converting the compound of Formula 3a to the compound of Formula 5a; viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises MnO2; x) reacting a compound of Formula 12a with a reducing agent to generate a compound of Formula 13a; xiv) converting the compound of Formula 13a to the compound of Formula 15a; xii) hydrogenating a compound of Formula 15a in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a; xix) reacting a compound of Formula 16a with a reducing agent to generate a compound of Formula 17a; xx) reacting the compound of Formula 17a with TDPSCl under basic conditions to generate a compound of Formula 18a; xxi) selectively deprotecting the compound of Formula 18a to generate the compound of Formula 19a; xvii) reacting a compound of Formula 19a with triisopropylbenzenesulfonyl chloride under basic conditions to generate a compound of Formula 20a; xviii) reacting the compound of Formula 20a with methanol under basic conditions to generate the compound of Formula 21a; xv) reacting a compound of Formula 21a with n-butyllithium in the presence of an organic solvent and a transition metal catalyst to generate a compound of Formula 22a; and xvi) converting the compound of Formula 22a to the compound of Formula I.", "In some implementations, the hydrogenation of the compound of Formula 15a occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).", "Some methods further comprise the step of: xxiv) reacting the compound of Formula I with diethanolamine in the presence of an organic solvent to generate the diethanolamine salt of the compound of Formula I.", "Some methods further comprise the step of: xxva) treating the compound of Formula I with an alkali metal hydroxide (e.g., NaOH, KOH, or like, or any combination thereof) in the presence of an alcohol (e.g., ethanol, methanol, iso-propanol, or any combination thereof) to generate the alkali metal salt (e.g., Na salt) of the compound of Formula I.", "In some implementations, the alkali metal hydroxide comprises NaOH.", "In other implementations, the alcohol comprises ethanol.", "Alternatively, some methods further comprise the step of: xxvi) treating the compound of wherein R2 is defined above, with an alkali metal hydroxide (e.g., NaOH, KOH, or like, or any combination thereof), in the presence of an alcohol and water to generate the alkali metal salt (e.g., Na salt) of the compound of Formula I.", "In some implementations, the alcohol comprises methanol.", "Some methods further comprise the step of: xxvii) recrystallizing the diethanolamine salt of the compound of Formula I to generate a first pure form of the diethanolamine salt of the compound of Formula I.", "(e.g., about 90% or greater chemical purity, about 95% or greater chemical purity, or about 97.5% or greater chemical purity).", "Some methods further comprise the step of: xxviii) reacting the first pure form of the diethanolamine salt of the compound of Formula I with an acid to generate a second pure form of the compound of Formula I (e.g., about 98% or greater chemical purity, about 98.5% or greater chemical purity, or about 99% or greater chemical purity).", "And, some methods further comprise the step of: xxvb) converting the second pure form of the compound of Formula I to an alkali metal salt.", "Another aspect of the present invention provides a compound of Formula 21 wherein R1 is C1-6 alkyl and each R3 is independently C1-6 alkyl or phenyl.", "In some embodiments, R1 is methyl, ethyl, propyl, iso-propyl, butyl, sec-butyl, or tert-butyl.", "In other embodiments, the —OSi(R3)3 group is selected from In some embodiments, R1 is methyl and the —OSi(R3)3 group is Another aspect of the present invention provides a compound of Formula 1a Another aspect of the present invention provides a compound of Formula 5 wherein each of R2 is independently selected from a C1-6 alkyl or phenyl.", "Another aspect of the present invention provides a compound of Formula 9a wherein R1 is C1-6 alkyl.", "Another aspect of the present invention provides a compound of Formula 13 wherein R1 is C1-6 alkyl and each R2 is independently selected from C1-6 alkyl or phenyl.", "Another aspect of the present invention provides a method of purifying a compound of Formula 1 comprising the steps of: xxx) reacting a compound of Formula 1 with a derivatizing reagent to generate a precipitate that is substantially insoluble in dichloromethane or mixture thereof (e.g., a mixture comprising dicloromethane and an alkane (e.g., heptane) (e.g., a mixture comprising dichloromethane and about 50% or more by volume heptane)); xxxi) collecting the precipitate and refluxing the precipitate in a solvent comprising an alcohol to generate the compound of Formula 1 having a chemical purity of about 98% or greater (e.g., about 98.5% or greater, about 99% or greater, or about 99.5% or greater) and an e.e.", "of about 98% or greater (e.g., about 98.5% or greater, about 99% or greater, or about 99.5% or greater); wherein the method excludes the use of any column chromatography (e.g., HPLC).", "In some implementations, the derivitizing reagent comprises 3,5-dinitrobenzoyl chloride and the alcohol comprises methanol.", "Another aspect of the present invention provides a method of purifying a compound of Formula 9 comprising the steps of: xl) reacting a compound of Formula 9, wherein R1 is C1-6 alkyl, with 3,5-dinitrobenzoyl chloride to generate a precipitate comprising a compound of Formula 9A; and xli) collecting the precipitate and treating the precipitate with a base in the presence of an alcohol to generate the compound of Formula 9 having a chemical purity of about 95% or greater (e.g., about 98% or greater, about 99% or greater, or about 99.5% or greater); wherein the method excludes the use of any column chromatography (e.g., HPLC).", "Some methods further comprise the step of: xlii) recrystallizing the precipitate of step xli).", "Another aspect of the present invention provides a method of generating a compound of Formula 5 wherein each of R2 is independently selected from a C1-6 alkyl or phenyl, comprising the steps of: iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e.", "of greater than about 98%; v) reacting the compound of Formula 1 with SiCl(R2)3, wherein each R2 is independently C1-6 alkyl or phenyl, under basic conditions to generate the compound of Formula 2; vi) reacting the compound of Formula 2 with 1-TMS-1-propyne to generate the compound of Formula 3; l) deprotecting the compound Formula 3 under basic condition to generate a compound of Formula 4, wherein each of R4 and R5 are H or —OSi(R2)3; and li) reacting the compound of Formula 4 with SiCl(R2)3 under basic conditions to generate the compound of formula 5, wherein the compound of Formula 5 has a chemical purity of about 98% or greater (e.g., about 98.5% or greater, about 99% or greater, or about 99.5% or greater) and an e.e.", "of about 98% or greater (e.g., about 98.5% or greater, about 99% or greater, or about 99.5% or greater).", "Steps iv)-vi) are discussed above.", "Another aspect of the present invention provides a method of generating a compound of Formula 13 wherein R1 is C1-6 alkyl and each R2 is independently selected from C1-6 alkyl or phenyl, comprising the step of: x) reacting a compound of Formula 12 with (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole in the presence of an organic solvent comprising THF and toluene to generate a compound of Formula 13 wherein the compound of Formula 13 has a chemical purity of greater than about 97% (e.g., about 97.5% or greater, about 98% or greater) and a d.e.", "of greater than about 97% (e.g., about 97.5% or greater, about 98% or greater, or about 98.5% or greater).", "Step x) is described in detail above.", "IV.", "General Synthetic Scheme General schemes for generating compounds of Formula I and salts thereof are provided below.", "In the general schemes above, R1, R2, and R3 are as defined above.", "Some methods of the present invention comprise one or more of the following reaction conditions: Step xxx): 1.3,5-dinitrobenzoyl chloride, DMAP, NEt3, CH2Cl2, 0° C. to rt 2.recrystallization Step iv): MeOH, reflux Step v): TBSCl, imidazole, DMF, 0° C. Step vi): 1-TMS-1-propyne, sec-BuLi, CuI, MTBE, −78° C. Step l): KOH, EtOH Step ii): TBSCl, imidazole, DMF, 0° C. Step xxii): 3-bromoprop-1-ene, sec-BuLi, Heptanes, 0° C. Step xxiii): 1N aq.", "HCl, MeOH Step xl): 1.3,5-dinitrobenzoyl chloride, DMAP, NEt3, CH2Cl2, 0° C. to r.t. 2.recrystallization Step xli): KOH, MeOH Step i): MnO2, CH2Cl2 Step ii): compound of Formula 5, sec-BuLi, THF, −78° C. to r.t.", "Step viii): MnO2, CH2Cl2 Step x): (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole, BH3, DMS, toluene/THF Step a): TBSCl, imidazole, DMF, 0° C. Step b): 1.Co2(CO)8, CH2Cl2, rt 2.CH3CN, reflux Step xii): H2, 10% Pd/C, K2CO3, MeOH or THF Step xix): NaBH4, aq.", "NaOH, EtOH, −10° C. Step xx): TBDPSCl, imidazole, DMF, 50° C. Step xxi): Aq.", "HCl, THF/MeOH or TBAF, THF, 0° C. Step xvii): triisopropylbenzene-sulfonyl chloride, Et3N, DMAP, CH2Cl2, 0° C. to r.t.", "Step xviii): K2CO3, MeOH Step xv): nBuLi, CuI, THF, −78° C. to r.t.", "Step c): Ph2PH, nBuLi, THF, −20° C. to reflux Step d): TBAF, THF, 50° C. Step e): R2 substituted 2-bromoacetate, K2CO3, KI, acetone Step f): KOH, MeOH Step xxiv): diethanolamine, EtOAc, EtOH, reflux to r.t.", "Step xxva): NaOH, EtOH Step xxvb): NaOH, EtOH Step xxvi): NaOH, H2O, MeOH Step xxvii): 3N aq.", "HCl, H2O VI.", "Alternative Steps The present invention also provides the following synthetic steps, wherein one or more of the following steps may be optionally substituted for one or more steps described above.", "Step A1): Step A2): Steps A3) and A4): Steps A5)-A7): Steps A8)-A11): Steps A12)-A23): Steps A24)-A30): Steps A31) and A32) Steps A33)-A36) Step A37) Step A38) VII.", "Examples The following examples are not intended to limit the scope of the present invention.", "Example 1: (R)-oxiran-2-ylmethyl 3,5-dinitrobenzoate (1a) Triethylamine (8.52 g/mL, 84.2 mmol, 1.25 equiv) and 4-dimethylaminopyridine (100 mg, 0.818 mmol, 0.01 equiv) were added to a solution of (S)-(−)-glycidol 1 (5.00 g, 67.5 mmol, 1.0 equiv, 99.5% ee) in anhydrous methylene chloride (100 mL) while stirring under nitrogen.", "The reaction was then warmed to 30° C. and 3,5-dinitrobenzoyl chloride (16.3 g, 70.9 mmol, 1.05 equiv) added drop-wise over 20 minutes as a solution in anhydrous methylene chloride (50 mL).", "After stirring at this temperature for 30 minutes, the reaction was quenched with addition of 10% aqueous potassium bicarbonate (50 mL) and cooled to room temperature while stirring for an additional 30 minutes.", "The two phases were separated and the organic phase washed with 10% aqueous citric acid (50 mL).", "The organic phase was then purified by filtration through a plug of silica gel giving 14.69 g of a white solid that was shown to be 99.4% e.e.", "by chiral HPLC.", "Recrystallization (180 mL of 3:2 v/v heptane-dichloromethane) afforded 11.5 g (64%) of the title compound as a white solid.", "Data for 1a: Rf=0.43 (100% methylene chloride); 1H NMR (400 MHz, CDCl3) δ 9.25-9.28 (m, 1H), 9.21 (d, J=2.20 Hz, 2H), 4.82 (dd, J=2.93, 12.45 Hz, 1H), 4.20-4.33 (m, 1H), 3.42 (tdd, J=2.61, 4.07, 6.82 Hz, 1H), 2.92-3.04 (m, 1H), 2.77 (dd, J=2.75, 4.58 Hz, 1H); MS (ESI+) m/z 291.0 (M+Na+).", "HPLC, ChiralPak IA column (4.6×250 mm2), 5 mm; flow rate 1.0 mL/min; 210 nm; mobile phase heptane (80%): ethanol (20%); retention time, 27.0 min, purity (100.0%).", "Example 2: (S)-(−)-glycidol (1, ˜100% ee) A solution of dinitrobenzoate 1a (30.06 g, 112.1 mmol, 1.0 equiv) in anhydrous methanol (190 mL) was heated to reflux for 2 hours while stirring, under nitrogen.", "The reaction was then cooled to 0° C. in an ice bath causing formation of a crystalline solid that was removed by filtration and rinsed with ice cold methanol (15 mL).", "The filtrate was concentrated under reduced pressure resulting in formation of a white slurry that was dissolved in tert-butyl methyl ether (20 mL) and concentrated to dryness.", "The residue was again slurried in methanol (15 mL), the solid removed by filtration and rinsed with more methanol (5 mL).", "The filtrate was concentrated to give 7.6 g (92%) of the title compound as a pale yellow oil.", "Data for 1: Rf=0.12 (20% EtOAc/heptane).", "Example 3: (R)-tert-butyldimethyl(oxiran-2-ylmethoxy)silane (2a) To a 0° C. solution of tert-butyl(chloro)dimethylsilane (26.540 g, 176.21 mmol, 1.3 equiv) and imidazole (14.786 g, 217.19 mmol, 1.6 equiv) in dimethylformamide (80 mL) was added (S)-oxiran-2-yl methanol (10.013 g, 135.16 mmol, 1.0 equiv) drop-wise and the resulting mixture stirred at that temperature under nitrogen for 30 minutes.", "The reaction was then quenched with addition of saturated aqueous ammonium chloride (200 mL) and water (200 mL).", "The resulting mixture was extracted with heptane (5×200 mL) and the combined organic phases were washed with brine, dried (MgSO4) and concentrated to give 25.142 g (99%) of the title compound as a yellow oil.", "This material was used in the next step without purification.", "Data for 2a: Rf=0.64 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 3.85 (dd, J=3.22, 12.01 Hz, 1H), 3.66 (dd, J=4.69, 12.01 Hz, 1H), 3.05-3.12 (m, 1H), 2.76 (dd, J=4.25, 5.13 Hz, 1H), 2.63 (dd, J=2.64, 4.98 Hz, 1H), 0.90 (s, 9H), 0.08 (s, 3H), 0.07 (s, 3H).", "Example 4: (R)-1-((tert-butyldimethylsilyl)oxy)-6-(trimethylsilyl)hex-5-yn-2-ol (3a) To a 3-neck flask fitted with a mechanical stirrer, a thermocouple and addition funnel was charged 1-(trimethylsilyl)-1-propyne (120.0 g, 1.07 mol, 2.2 equiv) followed by tert-butyl methyl ether (600 mL) while being kept under nitrogen.", "The solution was cooled to 0±5 OC while stirring and sec-butyllithium (696 mL, mmol, 2.0 equiv, 2 M in cyclohexane) was added slowly while maintaining the reaction temperature below 5° C. After complete addition, the resulting mixture was stirred at 0±5° C. under nitrogen for three hours.", "In a separate 3-neck flask fitted with a mechanical stirrer, a thermocouple, and addition funnel was charged epoxide 2a (92.5 g, 0.49 mol, 1.0 equiv) followed by tert-butyl methyl ether (1800 mL) and copper iodide (18.6 g, 0.1 mol, 0.2 equiv) while being kept under nitrogen.", "The resulting mixture was cooled to −78° C.±5° C. and then the 1-(trimethylsilyl)-1-propyne solution was cannulated into the epoxide reaction mixture.", "The resulting reaction mixture was allowed to slowly warm to room temperature.", "After stirring for 18 hours, the reaction was judged complete by TLC.", "The reaction was quenched with addition of 5% aqueous citric acid (1500 mL), the layers were separated and the lower aqueous layer was extracted with heptane (1000 mL).", "The combined organic phases were filtered through a pad of celite (150 g) and the filtrate was concentrated under reduced pressure to give 147 g (˜100%) of the title compound as a dark yellow/brown oil.", "This material was used in the next step without purification.", "Data for 3a: Rf=0.55 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 3.72-3.82 (m, 1H), 3.65 (dd, J=3.81, 9.96 Hz, 1H), 3.45 (dd, J=7.03, 9.96 Hz, 1H), 2.47 (d, J=3.81 Hz, 1H), 2.34-2.42 (m, 2H), 1.63 (q, J=7.13 Hz, 2H), 0.91 (s, 9H), 0.14 (s, 9H), 0.08 (s, 6H); MS (ESI+) m/z 324.4 (M+Na+).", "Example 5: (R)-1-((tert-butyldimethylsilyl)oxy)hex-5-yn-2-ol (4a) To a 3-neck flask fitted with a mechanical stirrer and thermocouple was charged (R)-1-((tert-butyldimethylsilyl)oxy)-6-(trimethylsilyl)hex-5-yn-2-ol 3a (147 g, 489 mmol, 1 equiv) dissolved in ethanol (1200 mL) under nitrogen.", "Solid potassium hydroxide pellets (55 g, 980 mmol, 2.0 equiv) was added and the resulting solution was stirred at room temperature for 2 hours.", "After completion of the reaction as judged by TLC, the reaction mixture was concentrated under reduced pressure.", "The crude residue was treated with heptane (1000 mL) and 10% citric acid solution (1700 mL) and the resulting mixture was stirred for 5 minutes.", "The layers were separated and the lower aqueous layer was extracted with heptane (700 mL).", "The combined organic phases were filtered through a pad of celite (120 g) and concentrated under reduced pressure to give 85 g (77%) of the title compound as a light brown oil.", "This material was an unquantified mixture of regioisomers due to migration of the silyl protecting group that was used in the next step without further purification.", "Purification of a small amount of crude 4a by chromatography (0% to 25% ethyl acetate/heptane gradient) provided analytically pure samples of 4b and 4c.", "Data for 4b: Rf=0.50 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 3.73-3.84 (m, 1H), 3.60-3.68 (m, 1H), 3.44 (dd, J=7.14, 10.07 Hz, 1H), 2.45 (br.", "s., 1H), 2.35 (dt, J=2.56, 7.14 Hz, 2H), 1.95 (t, J=2.56 Hz, 1H), 1.59-1.67 (m, 2H), 0.90 (s, 9H), 0.07 (s, 6H); MS (ESI+) m/z 229.2 (M+H+).", "Data for 4c: Rf=0.40 (20% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 3.84-3.97 (m, 1H), 3.56-3.66 (m, 1H), 3.43-3.54 (m, 1H), 2.25 (dt, J=2.56, 7.14 Hz, 2H), 1.96 (t, J=2.75 Hz, 1H), 1.89 (br.", "s., 1H), 1.65-1.81 (m, 2H), 0.78-0.98 (m, 9H), 0.12 (s, 3H), 0.10 (s, 3H); MS (ESI+) m/z 229.2 (M+H+).", "Example 6: (R)-5-(but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane (5a) To a 3-neck flask fitted with a mechanical stirrer, a thermocouple and addition funnel was charged tert-butyldimethylsilyl chloride (59.0 g, 391 mmol, 1.05 equiv) and imidazole (40.5 g, 595 mmol, 1.6 equiv) in dimethylformamide (1100 mL).", "The solution was cooled to 0±5 OC while stirring.", "Then, a solution of (R)-1-((tert-butyldimethylsilyl)oxy)hex-5-yn-2-ol 4a (85 g, 372 mmol, 1.0 equiv) dissolved in dimethylformamide (200 mL) and added slowly to the reaction while maintaining the temperature below 5° C. Upon complete addition, the resulting mixture was stirred at 0±5° C. under nitrogen for three hours and then was slowly warmed up to room temperature and stir under nitrogen for at least 15 hrs.", "The reaction mixture was then diluted with methyl tert-butyl ether (1500 mL) and quenched with 5% aqueous citric acid (1500 mL).", "The layers were separated and the lower aqueous layer was extracted with methyl tert-butyl ether (3×1000 mL).", "The combined organic phases were washed with 14% aqueous sodium chloride, and concentrated under reduced pressure to give an orange oil.", "Chromatography (1% to 10% ethyl acetate/heptane gradient) afforded 114 g (90%) of the title compound as a yellow oil.", "Data for 5a: Rf=0.89 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 3.72-3.84 (m, 1H), 3.56 (dd, J=5.13, 10.25 Hz, 1H), 3.41 (dd, J=6.59, 9.89 Hz, 1H), 2.19-2.35 (m, 2H), 1.90-1.95 (m, 1H), 1.75-1.89 (m, 1H), 1.54-1.66 (m, 1H), 0.90 (s, 9H), 0.89 (s, 9H), 0.09 (s, 3H), 0.08 (s, 3H), 0.06 (s, 6H); MS (ESI+) m/z 343.2 (M+H+).", "Chiral GC, Restek bDEXm column (30 m×0.32 mm), 65° C. for 40 min, 10° C./min to 130° C., 20° C./min to 200° C., 1 mL injection; retention time, 43.49 min (˜100% 5a); Chemical Purity GC, Restek Stabilwax column (30 m×0.32 mm), 60° C. for 2 min, 10° C./min to 230° C., 1 mL injection; retention time, 10.82 min (90.0% 5a).", "Example 7: tert-butyl((3-methoxybenzyl)oxy)dimethylsilane (7b) To a solution of 3-methoxybenzyl alcohol 6 (2500 g, 18.09 mol, 1.0 equiv) in dichloromethane (20 L, 8 volumes) was added imidazole (1466 g, 21.53 mol, 1.19 equiv) and the solution cooled to 15° C. while stirring under nitrogen.", "Once cooled, the solution was charged with tert-butyl(chloro)dimethyl-silane (3164 g, 20.99 mol, 1.16 equiv) over the next 9 minutes during which time an exotherm of 42.9° C. was observed.", "The reaction was then cooled to room temperature while stirring for 17 hours.", "The reaction was then quenched with 5% aqueous citric acid (20 L, 8 volumes) and the lower organic phase concentrated to give 4958 g of a pale yellow oil.", "Vacuum distillation done in two batches (bp ranges 115-120 OC, 132-135° C. at 5 torr) afforded 2336 g and 1964 g of a clear colorless oil, which totaled 4300 g (94%) of the title compound.", "Data for 7b: Rf=0.27 (1% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.25 (t, J=8.1 Hz, 1H), 6.91 (m, 1H), 6.79 (dd, J=2.4, 8.2 Hz, 2H), 4.74 (s, 2H), 3.82 (s, 3H), 0.96 (s, 9H), 0.11 (s, 6H); MS (ESI+) m/z 275.2 (M+Na+).", "Example 8: ((2-allyl-3-methoxybenzyl)oxy)(tert-butyl)dimethylsilane (8b) A solution of silane 7b (2660 g, 10.54 mol, 1.0 equiv) in heptane (13.30 L, 5 volumes) was treated drop-wise with sec-butyllithium (15.81 L, 22.13 mol, 2.1 equiv, 1.4 M in cyclohexane) over a period of 2 hours.", "The reaction was stirred at room temperature for 2 additional hours before cooling to 0° C. Once cooled, the reaction was treated drop-wise with allyl bromide (2805 g, 23.18 mol, 2.2 equiv) over the next 70 minutes.", "An exotherm of 17.6° C. was observed, and the reaction warmed to room temperature over the next 38 minutes.", "The reaction was stirred at room temperature for 20 hours and was then quenched with 20% aqueous ammonium chloride (13.30 L, 5 volumes).", "The organic phase was washed with 14% aqueous sodium chloride (5.32 L, 2 volumes) and was concentrated to give 3274 g of yellow oil.", "This material was deemed sufficiently pure to be carried forward.", "Data for 8b: Rf=0.64 (5% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.22 (t, J=8.1 Hz, 1H), 7.11 (d, J=7.7 Hz, 1H), 6.82 (d, J=8.4 Hz, 1H), 5.92 (m, 1H), 4.93 (m, 2H), 4.74 (s, 2H), 3.82 (s, 3H), 3.41 (dt, J=1.6, 6.0 Hz, 2H), 0.95 (s, 9H), 0.10 (s, 6H); MS (ESI+) m/z 315.2 (M+Na+).", "Example 9: (2-allyl-3-methoxyphenyl)methanol (9b) To a solution of silane 8b (3082 g, 10.54 mol, 1.0 equiv, theoretical weight) in methanol (30.82 L, 10 volumes) was added 6N aqueous hydrochloric acid (8.43 L, 8.431 mol, 0.8 equiv) and the reaction stirred at room temperature for 2 hours.", "The reaction was quenched with drop-wise addition of 10% aqueous potassium bicarbonate (15.41 L, 5 volumes) and then evaporated until approximately 10 volumes of methanol were removed.", "The resulting aqueous solution was extracted with ethyl acetate (15.41 L, 10 volumes).", "The combined organic phases were washed with 7% sodium chloride (15.41 L, 5 volumes) and concentrated to give 2582 g of a brown oil.", "Vacuum distillation (bp range 132-135° C. at 5 torr) afforded 1558 g (83%, 2 steps) of the title compound as a yellow oil.", "This material was deemed sufficiently pure to be carried forward.", "Data for 9b: Rf=0.36 (30% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.24 (t, J=8.1 Hz, 1H), 7.03 (d, J=7.7 Hz, 1H), 6.87 (d, J=8.1 Hz, 1H), 6.01 (m, 1H), 4.97 (dq, J=1.8, 10.0 Hz, 1H), 4.92 (dq, J=1.9, 17.1 Hz, 1H), 4.70 (s, 2H), 3.84 (s, 3H), 3.52 (dt, J=1.7, 5.9 Hz, 2H); MS (ESI+) m/z 201.1 (M+Na+).", "Example 10: 2-allyl-3-methoxybenzyl 3,5-dinitrobenzoate (9c) To a 0° C. solution of alcohol 9b (1558 g, 11.28 mol, 1.0 equiv) in dichloromethane (7.789 L, 5 volumes) was added 3,5-dinitrobenzoyl chloride (2860 g, 12.40 mol, 1.1 equiv) and 4-dimethylamino-pyridine (206.6 g, 1.690 mol, 0.15 equiv) resulting in an exotherm of 12.6° C. The reaction was cooled back to 0° C. and triethylamine (1.729 L, 12.40 mol, 1.1 equiv) was added drop-wise over the next 57 minutes, during which time an exotherm of 17.6° C. was observed.", "Upon completion of the triethylamine addition, the reaction was quenched with 10% aqueous potassium bicarbonate (7.789 L, 5 volumes) which generated an exotherm of 19.8° C. The lower organic layer was washed with 10% aqueous citric acid (7.789 L, 5 volumes) and concentrated to give 4118 g of a light brown amorphous solid.", "The crude solid was suspended in methanol (41.18 L, 10 volumes based on crude quantity) and was heated to 65° C. over 94 minutes to fully dissolve the solid.", "The solution was then cooled back to room temperature and the precipitated solid was isolated by filtration.", "The solid was vacuum dried at 40° C. for 20 hours to afford 2131 g (65%) of the title compound as a light yellow solid.", "This material was deemed sufficiently pure to be carried forward.", "Data for 9c: Rf=0.45 (30% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 9.22 (t, J=2.2 Hz, 1H), 9.16 (d, J=2.2 Hz, 2H), 7.28 (t, J=8.1 Hz, 1H), 7.08 (dd, J=0.9, 7.5 Hz, 1H), 6.97 (d, J=8.1 Hz, 1H), 5.99 (ddt, J=5.8, 10.1, 17.2 Hz, 1H), 5.49 (s, 2H), 4.98 (dq, J=1.8, 17.2 Hz, 1H), 4.89 (dq, J=1.7, 10.1 Hz, 1H), 3.87 (s, 3H), 3.57 (dt, J=1.8, 5.9 Hz, 2H); MS (ESI+) m/z 395.1 (M+Na+).", "Example 11: (2-allyl-3-methoxyphenyl)methanol (9b) To a slurry of dinitrobenzoate 9c (3463 g, 9.302 mol, 1.0 equiv) in methanol (17.32 L, 5 volumes) was added potassium hydroxide (719.9 g, 11.16 mol, 1.2 equiv) and water (3.463 L, 1 volume), generating an exotherm of 37.7° C. The reaction was cooled to room temperature while stirring over 1 hour and was then concentrated until 5 volumes of methanol was removed.", "The resulting slurry was dissolved in 10% aqueous citric acid (17.32 L, 5 volumes) and extracted with dichloromethane (17.32 L, 5 volumes).", "The solid dinitrobenzoic acid byproduct was removed by filtration and the filtrate was washed with 10% aqueous potassium carbonate (9.02 L, 5 volumes) and concentrated to afford 1464 g (88%) of the title compound as a dark green oil.", "This material was deemed sufficiently pure to be carried forward.", "Data for 9b: Rf=0.36 (30% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.24 (t, J=8.1 Hz, 1H), 7.03 (d, J=7.3 Hz, 1H), 6.87 (d, J=8.4 Hz, 1H), 6.01 (m, 1H), 4.96 (m, 2H), 4.70 (s, 2H), 3.84 (s, 3H), 3.52 (dt, J=1.6, 6.0 Hz, 2H); MS (ESI+) m/z 201.1 (M+Na+).", "Example 12: 2-Allyl-3-Methoxybenzaldehyde (10b) Manganese (IV) oxide (85.00 g, 977.6 mmol, 10.0 equiv) was added to a solution of alcohol 9b (17.424 g, 97.761 mmol, 1.0 equiv) in anhydrous methylene chloride (5 mL) and the mixture stirred under nitrogen for 16 hours.", "The reaction was then filtered through celite, the solids washed with heptane and the filtrate concentrated to give 534 mg (99%) of the title compound as a pale oil.", "Data for 10b: Rf=0.64 (30% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 10.28 (s, 1H), 7.49 (dd, J=1.1, 7.7 Hz, 1H), 7.36 (t, J=8.1 Hz, 1H), 7.13 (dd, J=0.9, 8.2 Hz, 1H), 6.02 (ddt, J=5.9, 10.0, 17.1 Hz, 1H), 5.02 (dq, J=1.6, 10.1, 5.0 Hz, 1H), 4.93 (dq, J=1.7, 17.2, 4.9 Hz, 1H), 3.88 (s, 3H), 3.86 (dt, J=1.8, 5.9 Hz, 2H); MS (ESI+) m/z 199.1 (M+Na+).", "Example 13: (6R)-1-(2-allyl-3-methoxyphenyl)-6,7-bis((tert-butyldimethylsilyl)oxy)hept-2-yn-1-ol (11c) A solution of alkyne 5a (1.070 g, 3.121 mmol, 1.1 equiv) in anhydrous MTBE (11 mL) that had been cooled to −78° C. was treated drop-wise with sec-butyllithium (2.20 mL, 3.12 mmol, 1.1 equiv, 1.4 M solution in cyclohexane) and the resulting mixture stirred at that temperature under nitrogen for 30 minutes.", "Then, aldehyde 10b (500 mg, 2.83 mmol, 1.0 equiv) was added drop-wise as a solution in MTBE (4 mL) and the reaction allowed to slowly warm to room temperature.", "After stirring for 17 hours, the reaction was quenched with addition of 10% aqueous citric acid (30 mL) and extracted with heptane (3×30 mL).", "The combined organic phases were then washed with brine and concentrated to give 1.6 g of a yellow oil.", "Chromatography (0% to 15% ethyl acetate/heptane gradient) afforded 1.340 g (91%) of the title compound as a pale yellow oil.", "Data for 11c: Rf=0.60 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.35 (d, J=7.91 Hz, 1H), 7.19-7.29 (m, 1H), 6.87 (dd, J=0.88, 8.20 Hz, 1H), 5.93-6.08 (m, 1H), 5.64 (s, 1H), 4.90-5.03 (m, 2H), 3.83 (s, 3H), 3.71-3.80 (m, 1H), 3.60-3.70 (m, 1H), 3.50-3.60 (m, 2H), 3.40 (dd, J=6.74, 9.96 Hz, 1H), 2.25-2.44 (m, 2H), 2.04 (br.", "s., 1H), 1.76-1.90 (m, 1H), 1.60 (dtd, J=6.30, 7.67, 13.81 Hz, 1H), 0.90 (s, 9H), 0.88 (s, 9H), 0.05 (s, 12H); MS (ESI+) m/z 541.4 (M+Na+).", "Example 14: (R)-1-(2-allyl-3-methoxyphenyl)-6,7-bis((tert-butyldimethylsilyl)oxy)hept-2-yn-1-one (12b) Manganese (IV) oxide (869 mg, 10.0 mmol, 10.0 equiv) was added to a solution of alcohol 11c (540 mg, 1.04 mmol, 1.0 equiv) in anhydrous methylene chloride (5 mL) and the mixture stirred under nitrogen for 16 hours.", "The reaction was then filtered through celite, the solids washed with heptane and the filtrate concentrated to give 534 mg (99%) of the title compound as a pale oil.", "Data for 12b: Rf=0.62 (normal phase, 20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.74 (dd, J=1.17, 7.81 Hz, 1H), 7.24-7.35 (m, 1H), 7.07 (dd, J=0.78, 8.20 Hz, 1H), 5.90-6.06 (m, 1H), 4.86-5.09 (m, 2H), 3.86 (s, 3H), 3.75-3.84 (m, 3H), 3.58 (dd, J=5.27, 9.96 Hz, 1H), 3.41 (dd, J=6.84, 9.96 Hz, 1H), 2.44-2.66 (m, 2H), 1.87-2.01 (m, 1H), 1.72 (dtd, J=5.86, 7.81, 13.67 Hz, 1H), 0.90 (s, 9H), 0.89 (s, 9H), 0.08 (s, 6H), 0.06 (s, 6H); MS (ESI+) m/z 517.2 (M+H+).", "Example 15: (1S,6R)-1-(2-allyl-3-methoxyphenyl)-6,7-bis((tert-butyldimethylsilyl)oxy)hept-2-yn-1-ol (13c) Aryl ketone 12b (95.7 g, 185 mmol, 1.0 equiv) was dissolved in THF (1900 mL) under nitrogen.", "(R)-(+)-2-methyl-CBS-oxazaborolidine (222 mL, 222 mmol, 1.2 equiv, 1 M solution in toluene) was added and the resulting mixture cooled to −50° C.±5° C. Borane-methyl sulfide complex (370 mL, 370 mmol, 4.0 equiv, 2.0 M solution in THF) was then added drop-wise over 20 minutes.", "After stirring at −50° C. for 75 minutes, the mixture was cautiously quenched with drop-wise addition of methanol (600 mL) and subsequently warmed to room temperature while stirring overnight.", "The quenched mixture was cooled to 0° C., diluted with ethyl acetate (2000 mL) and treated with 5% aqueous citric acid (1500 mL).", "The layers were separated and the aqueous phase was further extracted with ethyl acetate (2×1500 mL).", "The combined organic phases were washed with 14% sodium chloride solution (1500 mL) and concentrated under reduced pressure.", "The crude oil was chased with heptane (2×500 mL) to afford 96.35 g of a pale oil.", "This material was deemed sufficiently pure to be carried forward crude.", "Data for 13c: Rf=0.58 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.35 (dd, J=1.03, 7.76 Hz, 1H), 7.20-7.29 (m, 1H), 6.87 (dd, J=0.88, 8.20 Hz, 1H), 6.00 (tdd, J=5.64, 10.18, 17.21 Hz, 1H), 5.63 (br.", "s., 1H), 4.87-5.06 (m, 2H), 3.83 (s, 3H), 3.75 (dddd, J=4.25, 5.27, 6.66, 7.84 Hz, 1H), 3.61-3.69 (m, 1H), 3.51-3.61 (m, 2H), 3.40 (dd, J=6.74, 9.96 Hz, 1H), 2.26-2.42 (m, 2H), 2.06 (br.", "s., 1H), 1.78-1.90 (m, 1H), 1.60 (dtd, J=5.86, 7.95, 13.70 Hz, 1H), 0.90 (s, 9H), 0.88 (s, 9H), 0.05 (s, 12H); MS (ESI+) m/z 541.2 (M+Na+); HPLC, ChiralPak IA column (4.6×250 mm2), 5 mm; flow rate 1.0 mL/min; 210 nm; mobile phase heptane (99%): 2-propanol (1%): trifluoroacetic acid (0.1%); retention time, 8.66 min (1.2%, (1R,6R)-1-(2-allyl-3-methoxyphenyl)-6,7-bis((tert-butyldimethylsilyl)oxy)hept-2-yn-1-ol), retention time, 9.48 min (98.8%, 13c).", "Example 16: (5S,10R)-5-(2-allyl-3-methoxyphenyl)-10-((tert-butyldimethylsilyl)oxy)-2,2,3,3,13,13,14,14-octamethyl-4,12-dioxa-3,13-disilapentadec-6-yne (14c) Imidazole (1.732 g, 25.44 mmol, 1.2 equiv) and tert-butyl(chloro)dimethylsilane (3.545 g, 23.32 mmol, 1.1 equiv) were added to a stirred, 0° C. solution of alkynol 13c (11.002 g, 21.20 mmol, 1.0 equiv) in anhydrous DMF under nitrogen and the mixture was then warmed to room temperature.", "The reaction was then quenched with addition of saturated aqueous ammonium chloride (100 mL) and water (100 mL).", "The resulting mixture was extracted with heptane (3×200 mL) and the combined organic phases were washed with water, brine, dried (MgSO4) and concentrated to give 13.351 g (99%) of the title compound as a pale yellow oil.", "This material was deemed sufficiently pure to be carried forward.", "Data for 14c: Rf=0.82 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCL3) δ 7.25-7.32 (m, 1H), 7.18-7.25 (m, 1H), 6.82 (d, J=8.20 Hz, 1H), 5.88-6.04 (m, 1H), 5.58 (s, 1H), 4.88-5.03 (m, 2H), 3.82 (s, 3H), 3.67-3.76 (m, 1H), 3.57-3.66 (m, 1H), 3.46-3.57 (m, 2H), 3.37 (dd, J=6.45, 9.96 Hz, 1H), 2.16-2.34 (m, 2H), 1.70-1.85 (m, 1H), 1.47-1.60 (m, 1H), 0.91 (s, 9H), 0.89 (s, 9H), 0.87 (s, 9H), 0.12 (s, 3H), 0.09 (s, 3H), 0.04 (s, 12H); MS (ESI+) m/z 655.5 (M+Na+).", "Example 17: (4R,9aS)-3-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-4-((tert-butyldimethylsilyl)oxy)-8-methoxy-9,9a-dihydro-1H-cyclopenta[b]naphthalen-2(4H)-one (15d) Cobalt carbonyl (7.197 g, 21.05 mmol, 1.0 equiv) was added to a solution of compound 14c (13.326 g, 21.05 mmol, 1.0 equiv) in anhydrous methylene chloride and the reaction stirred at room temperature under nitrogen for 2 hours to allow for formation of the cobalt-alkyne complex.", "The reaction was then concentrated by rotary evaporation, the residue dissolved in anhydrous acetonitrile and the mixture heated to reflux with stirring for 18 hours.", "The reaction was then cooled to room temperature, filtered through celite, and the precipitate washed with several portions of acetone.", "The filtrate was concentrated to give 14.9 g of an amber oil.", "Chromatography (0% to 20% ethyl acetate/heptane gradient) afforded 13.803 g (99%) of the title compound as a colorless oil.", "Data for 15d: Rf=0.57 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.24 (t, J=7.91 Hz, 1H), 6.91 (d, J=7.62 Hz, 1H), 6.79 (d, J=7.91 Hz, 1H), 5.51 (s, 1H), 3.83 (s, 3H), 3.61-3.71 (m, 1H), 3.30-3.59 (m, 4H), 2.70 (dd, J=6.45, 18.75 Hz, 1H), 2.35-2.48 (m, 1H), 2.10-2.32 (m, 3H), 1.57 (td, J=7.58, 15.01 Hz, 2H), 0.91 (s, 9H), 0.88 (s, 9H), 0.82 (s, 9H), 0.00-0.14 (m, 18H); MS (ESI+) m/z 683.4 (M+Na+).", "Example 18a: (3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-3a,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-2(3H)-one (16d) To a solution of tricyclic enone 15d (14.86 g, 22.48 mmol, 1.0 equiv) in absolute methanol (225 mL) was added anhydrous potassium bicarbonate (743 mg, 5% w/w) and 10% Pd/C (3.715 g, 50% wet, 25% w/w) and the mixture was hydrogenated with a balloon of hydrogen gas while stirring at room temperature for 64 hours.", "The reaction mixture was then filtered through celite, the residue washed with several portions of ethanol, and the filtrate concentrated to give a yellow oil.", "Triteration with heptane caused formation of a small amount of precipitate that was filtered off, and the filtrate concentrated to give 12.5 g of a viscous, yellow oil.", "Chromatography (0% to 10% ethyl acetate/heptane gradient) afforded 10.998 g (92%) of the title compound as a pale oil.", "Data for 16d: Rf=0.47 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.11 (t, J=7.81 Hz, 1H), 6.71 (d, J=8.20 Hz, 2H), 3.84 (s, 3H), 3.62-3.76 (m, 1H), 3.52-3.61 (m, 1H), 3.43 (dd, J=6.84, 9.96 Hz, 1H), 2.10-3.08 (m, 8H), 1.19-2.04 (m, 5H), 0.91 (d, J=8.98 Hz, 18H), 0.01-0.18 (m, 12H); MS (ESI+) m/z 533.2 (M+H+).", "Example 18b: (3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-3a,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-2(3H)-one (16d) To a solution of tricyclic enone 15d (1.0 g, mmol, 1.0 equiv) in methanol (10 mL) was added anhydrous potassium carbonate (53 mg, 5% w/w) and 10% Pd/C (100 mg, 50% wet, 10% w/w) and the mixture was hydrogenated under 10 psi hydrogen gas while stirring at room temperature for about 18 hours.", "The reaction mixture was then filtered through celite, the residue was washed with several portions of MTBE, and the filtrate concentrated to give a yellow oil.", "Triteration with MTBE caused formation of a small amount of precipitate that was filtered off, and the filtrate concentrated to give 0.98 g of viscous, yellow oil.", "This material was deemed sufficiently pure to be carried forward, but was purified for analytical characterization.", "Chromatography (0% to 2.5% ethyl acetate/heptane) afforded 0.711 g (88%) of the title compound as a viscous, colorless oil.", "Data for 16d: Rf=0.64 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.11 (t, J=7.81 Hz, 1H), 6.71 (d, J=8.20 Hz, 2H), 3.84 (s, 3H), 3.62-3.76 (m, 1H), 3.52-3.61 (m, 1H), 3.43 (dd, J=6.84, 9.96 Hz, 1H), 2.10-3.08 (m, 8H), 1.19-2.04 (m, 5H), 0.91 (d, J=8.98 Hz, 18H), 0.01-0.18 (m, 12H); MS (ESI+) m/z 533.2 (M+H+).", "Example 18c: (3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-3a,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-2(3H)-one (16d) To a solution of tricyclic enone 15d (500 mg, 0.756 mmol, 1.0 equiv) in ethyl acetate (7.5 mL) was added anhydrous potassium carbonate (25 mg, 5% w/w) and 10% Pd/C (75 mg, 50% wet, 15% w/w).", "The mixture was hydrogenated under 10 psi hydrogen gas while shaking in a Parr flask at room temperature for 24 hours.", "The reaction was then charged with additional 10% Pd/C (75 mg, 50% wet, 15% w/w), and hydrogenated under 10 psi hydrogen gas while shaking in a Parr flask at room temperature for 24 more hours.", "At this point the reaction was shown to be complete by TLC and was filtered through celite, the residue was washed with several portions of ethyl acetate, and the filtrate concentrated to give 404 mg of a light yellow oil.", "Chromatography (0% to 5% ethyl acetate/heptane gradient) afforded 290 mg (72%) of the title compound as a viscous, colorless oil.", "Data for 16d: Rf=0.47 (20% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.11 (t, J=7.81 Hz, 1H), 6.71 (d, J=8.20 Hz, 2H), 3.84 (s, 3H), 3.62-3.76 (m, 1H), 3.52-3.61 (m, 1H), 3.43 (dd, J=6.84, 9.96 Hz, 1H), 2.10-3.08 (m, 8H), 1.19-2.04 (m, 5H), 0.91 (d, J=8.98 Hz, 18H), 0.01-0.18 (m, 12H); MS (ESI+) m/z 533.2 (M+H+).", "Example 18d: (3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-3a,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-2(3H)-one (16d) To a solution of tricyclic enone 15d (1.000 g, 1.513 mmol, 1.0 equiv) in 2-methyltetrahydrofuran (15 mL) was added anhydrous potassium carbonate (50 mg, 5% w/w) and 10% Pd/C (150 mg, 50% wet, 10% w/w) and the mixture was hydrogenated under 10 psi hydrogen gas while stirring at room temperature for about 18 hours.", "The reaction was then charged with additional 10% Pd/C (150 mg, 50% wet, 15% w/w), and hydrogenated under 10 psi hydrogen gas while stirring at room temperature for about 23 hours.", "At this point the reaction was shown to be complete by TLC and was filtered through celite, the residue was washed with several portions of ethyl acetate, and the filtrate concentrated to give 984 mg of a light yellow oil.", "Chromatography (0% to 5% ethyl acetate/heptane gradient) afforded 507 mg (63%) of the title compound as a viscous, colorless oil.", "Data for 16d: Rf=0.47 (20% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.11 (t, J=7.81 Hz, 1H), 6.71 (d, J=8.20 Hz, 2H), 3.84 (s, 3H), 3.62-3.76 (m, 1H), 3.52-3.61 (m, 1H), 3.43 (dd, J=6.84, 9.96 Hz, 1H), 2.10-3.08 (m, 8H), 1.19-2.04 (m, 5H), 0.91 (d, J=8.98 Hz, 18H), 0.01-0.18 (m, 12H); MS (ESI+) m/z 533.2 (M+H+).", "Example 18e: (3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-3a,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-2(3H)-one (16d) To a solution of tricyclic enone 15d (1.465 g, 2.216 mmol, 1.0 equiv) in absolute ethanol (225 mL) was added anhydrous potassium carbonate (126 mg, 8.5% w/w) and 10% Pd/C (225 mg, 50% wet, 15% w/w) and the mixture was hydrogenated at atmospheric pressure of hydrogen gas while stirring at room temperature overnight.", "The reaction mixture was then filtered through celite, the residue washed with several portions of ethanol, and the filtrate concentrated to give yellow oil.", "Triteration with heptane caused formation of a small amount of precipitate that was filtered off, and the filtrate was concentrated to give a viscous, yellow oil.", "The crude oil was dissolved in ethanol (15 mL) and DI water (7 mL) was added slowly to the stirred solution.", "The white solid was filtered and washed with a 1:1 mixture of ethanol and DI water.", "The solid was dried under vacuum overnight to afford 985 mg (83%) of the title compound as a white solid.", "Data for 16d: Rf=0.47 (20% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.11 (t, J=7.81 Hz, 1H), 6.71 (d, J=8.20 Hz, 2H), 3.84 (s, 3H), 3.62-3.76 (m, 1H), 3.52-3.61 (m, 1H), 3.43 (dd, J=6.84, 9.96 Hz, 1H), 2.10-3.08 (m, 8H), 1.19-2.04 (m, 5H), 0.91 (d, J=8.98 Hz, 18H), 0.01-0.18 (m, 12H); MS (ESI+) m/z 533.2 (M+H+).", "Example 18f: (3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-3a,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-2(3H)-one (16d) To a solution of tricyclic enone 15d (1.425 g, 2.155 mmol, 1.0 equiv) in absolute ethanol (225 mL) was added anhydrous potassium carbonate (116 mg, 8% w/w) and 10% Pd/C (220 mg, 50% wet, 15% w/w) and the mixture was hydrogenated under 10 psi of hydrogen gas while stirring at room temperature overnight.", "The reaction mixture was then filtered through celite, the residue washed with several portions of ethanol, and the filtrate concentrated to give a yellow oil.", "Triteration with heptane caused formation of a small amount of precipitate that was filtered off, and the filtrate was concentrated to give a viscous, yellow oil.", "The crude oil was dissolved in ethanol (15 mL) and DI water (7 mL) was added slowly to the stirred solution.", "The white solid was filtered and washed with a 1:1 mixture of ethanol and DI water.", "The solid was dried under vacuum overnight to afford 1.51 g (91%) of the title compound as a white solid.", "Data for 16d: Rf=0.47 (20% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.11 (t, J=7.81 Hz, 1H), 6.71 (d, J=8.20 Hz, 2H), 3.84 (s, 3H), 3.62-3.76 (m, 1H), 3.52-3.61 (m, 1H), 3.43 (dd, J=6.84, 9.96 Hz, 1H), 2.10-3.08 (m, 8H), 1.19-2.04 (m, 5H), 0.91 (d, J=8.98 Hz, 18H), 0.01-0.18 (m, 12H); MS (ESI+) m/z 533.2 (M+H+).", "Example 18g: (3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-3a,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-2(3H)-one (16d) To a solution of tricyclic enone 15d (2.0 g, 3.0 mmol, 1.0 equiv) in methanol (15 mL) was added anhydrous potassium carbonate (141 mg, 7% w/w) and 10% Pd/C (294 mg, 50% wet, 15% w/w) and the mixture was hydrogenated at atmospheric pressure of hydrogen gas while stirring at room temperature overnight.", "The reaction was then filtered through celite, the residue washed with several portions of methanol, and the filtrate concentrated to give a yellow oil.", "Triteration with heptane caused formation of a small amount of precipitate that was filtered off.", "The filtrate was concentrated to give a viscous, yellow oil.", "Chromatography (0% to 3% ethyl acetate/heptane gradient) afforded 1.51 g (94%) of the title compound as white solid.", "Data for 16d: Rf=0.47 (20% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.11 (t, J=7.81 Hz, 1H), 6.71 (d, J=8.20 Hz, 2H), 3.84 (s, 3H), 3.62-3.76 (m, 1H), 3.52-3.61 (m, 1H), 3.43 (dd, J=6.84, 9.96 Hz, 1H), 2.10-3.08 (m, 8H), 1.19-2.04 (m, 5H), 0.91 (d, J=8.98 Hz, 18H), 0.01-0.18 (m, 12H); MS (ESI+) m/z 533.2 (M+H+).", "Example 18h: (3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-3a,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-2(3H)-one (16d) To a solution of tricyclic enone 15d (1.42 g, 2.15 mmol, 1.0 equiv) in methanol (15 mL) was added anhydrous potassium bicarbonate (110 mg, 8% w/w) and 10% Pd/C (220 mg, 50% wet, 15% w/w) and the mixture was hydrogenated at 10 psi of hydrogen gas while stirring at room temperature for 24 hours.", "The reaction was then charged with additional anhydrous potassium bicarbonate (110 mg, 8% w/w) and 10% Pd/C (220 mg, 50% wet, 15% w/w) and hydrogenated under 10 psi hydrogen gas while stirring at room temperature for about 24 hours.", "The reaction was then filtered through celite, the residue washed with several portions of methanol, and the filtrate concentrated to give a yellow oil.", "Triteration with heptane caused formation of a small amount of precipitate that was filtered off, and the filtrate concentrated to give 12.5 g of a viscous, yellow oil.", "Chromatography (0% to 10% ethyl acetate/heptane gradient) afforded 722 mg (63%) of the title compound as a pale oil.", "Data for 16d: Rf=0.47 (20% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.11 (t, J=7.81 Hz, 1H), 6.71 (d, J=8.20 Hz, 2H), 3.84 (s, 3H), 3.62-3.76 (m, 1H), 3.52-3.61 (m, 1H), 3.43 (dd, J=6.84, 9.96 Hz, 1H), 2.10-3.08 (m, 8H), 1.19-2.04 (m, 5H), 0.91 (d, J=8.98 Hz, 18H), 0.01-0.18 (m, 12H); MS (ESI+) m/z 533.2 (M+H+).", "Examples 18i-18s: (3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-3a,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-2(3H)-one (16d) The hydrogenation of tricyclic enone 15d to generate ketone 16d was performed using a 10% Pd/C (50% wet) catalyst and other reaction conditions provided in Table 1: TABLE 1 Reaction conditions for the hydrogenation of tricyclic enone 15d.", "H2 % yield Ex.", "# Catalyst Base (wt %) Solvent pressure 16d i 15 wt % K2CO3 (5) MeOH 10 psi 76 j 15 wt % K2CO3 (5) EtOAc 10 psi 72 (×2) k 15 wt % K2CO3 (5) THF 10 psi 102 (×2) l 15 wt % K2CO3 (5) THF 10 psi 100 (×2) m 15 wt % KHCO3 (2 × MeOH 10 psi 63 7.7) n 15 wt % KHCO3 (2 × MeOH atm 79 7.7) o 15 wt % KHCO3 (8.2) EtOH 10 psi 83 p 15 wt % KHCO3 (7.4) EtOH atm 54 q 15 wt % K2CO3 (5) 2-Me- 10 psi 63 (×2) THF r 15 wt % K2CO3 (5) EtOH 10 psi 64 s 15 wt % KHCO3 (5) EtOH 10 psi 87 (×2) Example 19a: (1R,2R,3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol (17c) Sodium hydroxide (5.492 g in 28 mL of water, 20% solution in water, 10 equiv) was added to a −10° C. solution of ketone 16d (7.318 g, 13.73 mmol, 1.0 equiv) in absolute ethanol and the reaction was stirred under nitrogen for 30 minutes.", "Then, sodium borohydride (545 mg, 14.42 mmol, 1.05 equiv) was added in one portion and the reaction maintained at −10° C. for 1 hour with stirring.", "At that point, an additional portion of sodium borohydride (545 mg, 14.42 mmol, 1.05 equiv) was added and the reaction stirred at −10° C. for 17 hours.", "The reaction was then cautiously quenched with addition of glacial acetic acid (10 mL), resulting in a pH of 6.This was diluted with brine (200 mL) and warmed to room temperature.", "The mixture was extracted with heptane (3×200 mL), the combined organic phases dried (MgSO4) and concentrated to give a yellow oil.", "Chromatography (0% to 15% ethyl acetate/heptane gradient) afforded 5.359 g (73%) of the title compound as a viscous, colorless oil.", "Data for 17c: Rf=0.53 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.11 (t, J=7.91 Hz, 1H), 6.76 (dd, J=2.78, 7.76 Hz, 2H), 3.82 (s, 3H), 3.62-3.78 (m, 2H), 3.51-3.60 (m, 1H), 3.39-3.49 (m, 1H), 2.70-2.87 (m, 2H), 2.48 (ddd, J=6.59, 11.35, 14.57 Hz, 2H), 2.12-2.31 (m, 2H), 1.84-1.97 (m, 1H), 1.44-1.80 (m, 5H), 1.22-1.32 (m, 1H), 1.10-1.22 (m, 1H), 0.91 (s, 18H), 0.01-0.16 (m, 12H); MS (ESI+) m/z 557.5 (M+Na+).", "Example 19b: (R)-4-((1R,2R,3aS,9aS)-2-hydroxy-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)butane-1,2-diol (17d) Sodium hydroxide (648 mg in 3.2 mL of water, 20% solution in water, 16.2 mmol, 10 equiv) was added to a −10° C. solution of ketone 16d (864 mg, 1.62 mmol, 1.0 equiv) in absolute ethanol and the reaction was stirred under nitrogen for 30 minutes.", "Then, sodium borohydride (68 mg, 1.80 mmol, 1.1 equiv) was added in one portion and the reaction maintained at −10° C. for 1 hour with stirring.", "At that point, an additional portion of sodium borohydride (68 mg, 1.80 mmol, 1.1 equiv) was added and the reaction stirred at −10° C. for 17 hours.", "The reaction was then cautiously quenched with addition of 3 N aqueous HCl (10 mL) until the pH was about 1, the reaction was warmed to room temperature and stirred 2 hours until homogenous.", "This was concentrated by rotary evaporation to remove the ethanol, diluted with brine (10 mL) and the resulting white slurry extracted with a solution of 10% ethanol/isopropyl acetate (3×20 mL).", "The combined organic phases were dried (Na2SO4) and concentrated to give 530 mg of an off-white solid.", "The crude product was recrystallized by dissolving in refluxing ethyl acetate (10 mL) and cooling back to room temperature giving 432 mg (87%) of the title compound as a white solid.", "Data for 17d: Rf=0.18 (100% EtOAc); 1H NMR (400 MHz, DMSO-d6) δ 7.07 (t, J=7.87 Hz, 1H), 6.80 (d, J=8.42 Hz, 1H), 6.74 (d, J=7.32 Hz, 1H), 4.48 (d, J=5.49 Hz, 1H), 4.44 (t, J=5.31 Hz, 1H), 4.37 (d, J=4.39 Hz, 1H), 3.74 (s, 3H), 3.40-3.53 (m, 1H), 3.36-3.40 (m, 1H), 3.22-3.32 (m, 2H), 2.64 (ddd, J=6.59, 8.51, 14.56 Hz, 2H), 2.32-2.47 (m, 2H), 2.03-2.19 (m, 1H), 1.87-2.00 (m, 1H), 1.71-1.84 (m, 1H), 1.60-1.71 (m, 1H), 1.46-1.60 (m, 1H), 1.22-1.40 (m, 2H), 1.01-1.14 (m, 1H), 0.84-1.01 (m, 1H); MS (ESI+) m/z 329.2 (M+Na+).", "Example 20a: (R)-5-(2-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)ethyl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane (18d) Imidazole (1.017 g, 14.94 mmol, 1.5 equiv) and tert-butyl(chloro)diphenylsilane (3.557 g, 12.94 mmol, 1.3 equiv) were added to a stirred solution of alcohol 17c (5.326 g, 9.957 mmol, 1.0 equiv) in anhydrous DMF, under nitrogen, and the mixture was then warmed to 50° C. for 40 hours.", "The reaction was then quenched with addition of saturated aqueous ammonium chloride (100 mL) and extracted with heptane (3×100 mL).", "The combined organic phases were washed with water, brine and concentrated to give a pale yellow oil.", "Chromatography (0% to 10% ethyl acetate/heptane gradient) afforded 7.186 g (93%) of the title compound as a viscous, colorless oil.", "Data for 18d: Rf=0.74 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.67 (dd, J=6.77, 14.46 Hz, 4H), 7.30-7.49 (m, 6H), 7.11 (t, J=7.69 Hz, 1H), 6.69-6.83 (m, 2H), 3.73-3.88 (m, 4H, contains s, 3H, 3.79), 3.53-3.65 (m, 1H), 3.43-3.52 (m, 1H), 3.32-3.43 (m, 1H), 2.92 (dd, J=6.23, 14.65 Hz, 1H), 2.77 (dd, J=5.86, 14.28 Hz, 1H), 2.52 (dd, J=8.79, 14.28 Hz, 1H), 2.28 (dd, J=8.42, 14.65 Hz, 1H), 1.96 (sxt, J=8.06 Hz, 1H), 1.48-1.83 (m, 5H), 1.14-1.45 (m, 3H), 1.03 (s, 9H), 0.90 (d, J=4.03 Hz, 18H), 0.06 (t, J=3.30 Hz, 12H).", "Example 20b: (1R,2R,3aS,9aS)-1-(2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol (18e) PTSA.H2O (15 mg, 0.082 mmol, 0.05 equiv) was added to a solution of 17d (500 mg, 1.53 mmol, 1.0 equiv) and 2,2-dimethoxypropane (0.40 mL, 3.2 mmol, 2.0 equiv) in anhydrous DMF (5 mL), under nitrogen, and the mixture was stirred at room temperature for 22 hours.", "The reaction was then quenched with addition of saturated aqueous sodium bicarbonate (5 mL), diluted with water (5 mL) and extracted with ethyl acetate (3×10 mL).", "The combined organic phases were washed with brine, dried (MgSO4) and concentrated to give 997 mg of a light brown oil.", "Chromatography (25% to 60% ethyl acetate/heptane gradient) afforded 529 mg (94%) of the title compound as a colorless oil.", "Data for 18a: Rf=0.32 (50% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.10 (t, J=7.87 Hz, 1H), 6.76 (t, J=8.24 Hz, 2H), 3.96-4.17 (m, 2H), 3.80 (s, 3H), 3.64-3.75 (m, 1H), 3.53 (t, J=7.51 Hz, 1H), 2.76 (ddd, J=6.23, 12.27, 14.46 Hz, 2H), 2.41-2.59 (m, 2H), 2.19-2.33 (m, 1H), 2.09-2.19 (m, 1H), 2.05 (s, 1H), 1.56-1.95 (m, 4H), 1.44-1.55 (m, 1H), 1.42 (s, 3H), 1.37 (s, 3H), 1.21-1.32 (m, 1H), 1.06-1.19 (m, 1H); MS (ESI+) m/z 369.1 (M+Na+).", "Example 20c: Tert-butyl(((1R,2R,3aS,9aS)-1-(2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-5-methoxy-2,3,3a,4,9,9a-hexahydro-H-cyclopenta[b]naphthalen-2-yl)oxy)diphenylsilane (18f) Imidazole (145 mg, 2.13 mmol, 1.4 equiv) and tert-butyl(chloro)diphenylsilane (501 mg, 1.82 mmol, 1.2 equiv) were added to a stirred solution of alcohol 18e (526 mg, 1.52 mmol, 1.0 equiv) in anhydrous DMF (7.5 mL), under nitrogen, and the mixture was then warmed to 50° C. for 19 hours.", "The reaction was then quenched with water (10 mL) and extracted with heptane (3×10 mL).", "The combined organic phases were washed with 14% aqueous sodium chloride and concentrated to give 989 mg of a pale yellow oil.", "Chromatography (0% to 10% ethyl acetate/heptane gradient) afforded 882 mg (99%) of the title compound as a colorless oil.", "Data for 18f: Rf=0.55 (20% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.69 (dt, J=6.59, 17.21 Hz, 4H), 7.32-7.49 (m, 6H), 7.12 (t, J=7.69 Hz, 1H), 6.77 (t, J=8.06 Hz, 2H), 3.89-3.99 (m, 2H), 3.72-3.84 (m, 4H), 3.25-3.43 (m, 1H), 2.89 (dd, J=6.23, 14.65 Hz, 1H), 2.75 (dd, J=6.23, 14.28 Hz, 1H), 2.51 (dd, J=8.24, 14.10 Hz, 1H), 2.34 (dd, J=8.06, 14.65 Hz, 1H), 1.48-2.08 (m, 7H), 1.24-1.46 (m, 7H), 1.18 (td, J=4.94, 9.89 Hz, 1H), 1.04 (s, 9H).", "Example 21a: (R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)butane-1,2-diol (19d) Aqueous 3N hydrochloric acid (10 mL) was added to a solution of TBDMS ether 18d (4.411 g, 5.704 mmol, 1.0 equiv) in THF (30 mL) and MeOH (10 mL) and the reaction stirred at room temperature for 27 hours.", "The reaction was then concentrated to remove the organic solvents, diluted with water (50 mL), and extracted with EtOAc (3×100 mL).", "The combined organic phases were washed with saturated aqueous sodium bicarbonate, brine, dried (Na2SO4) and concentrated to give a foamy oil.", "Chromatography (20% to 80% ethyl acetate/heptane gradient) afforded 1.982 g (64%) of the title compound as a fluffy white solid.", "Data for 19d: Rf=0.26 (40% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.60-7.76 (m, 4H), 7.32-7.49 (m, 6H), 7.12 (t, J=7.78 Hz, 1H), 6.77 (t, J=7.78 Hz, 2H), 3.72-3.85 (m, 4H, contains s, 3H, 3.80), 3.48-3.59 (m, 2H), 3.27-3.39 (m, 1H), 2.90 (dd, J=6.13, 14.74 Hz, 1H), 2.74 (dd, J=6.04, 14.10 Hz, 1H), 2.50 (dd, J=8.24, 14.10 Hz, 1H), 2.34 (dd, J=7.78, 14.74 Hz, 1H), 1.84-2.08 (m, 2H), 1.80 (s, 2H), 1.72 (td, J=8.03, 16.34 Hz, 1H), 1.48-1.62 (m, 2H), 1.15-1.46 (m, 4H), 1.04 (s, 9H); MS (ESI+) m/z 567.5 (M+Na+).", "Example 21b: (R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)butane-1,2-diol (19d) Tetra-n-butylammonium fluoride (2.75 mL, 2.75 mmol, 2.0 equiv, 1.0 M solution in THF) was added to an ice-cold solution of TBDMS ether 18d (1.053 g, 1.362 mmol, 1.0 equiv) in THF (10 mL) and the reaction stirred at 0° C. for 3 hours.", "The reaction was then quenched with saturated aqueous ammonium chloride (10 mL), diluted with water (10 mL) and extracted with ethyl acetate (3×20 mL).", "The combined organic phases were dried (Na2SO4) and concentrated to give 1.03 g of a yellow oil.", "Chromatography (30% to 100% ethyl acetate/heptane gradient) afforded 616 mg (83%) of the title compound as a white, foamy solid.", "Data for 19d: Rf=0.26 (40% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.60-7.76 (m, 4H), 7.32-7.49 (m, 6H), 7.12 (t, J=7.78 Hz, 1H), 6.77 (t, J=7.78 Hz, 2H), 3.72-3.85 (m, 4H, contains s, 3H, 3.80), 3.48-3.59 (m, 2H), 3.27-3.39 (m, 1H), 2.90 (dd, J=6.13, 14.74 Hz, 1H), 2.74 (dd, J=6.04, 14.10 Hz, 1H), 2.50 (dd, J=8.24, 14.10 Hz, 1H), 2.34 (dd, J=7.78, 14.74 Hz, 1H), 1.84-2.08 (m, 2H), 1.80 (s, 2H), 1.72 (td, J=8.03, 16.34 Hz, 1H), 1.48-1.62 (m, 2H), 1.15-1.46 (m, 4H), 1.04 (s, 9H); MS (ESI+) m/z 567.3 (M+Na+).", "Example 21c: (R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)butane-1,2-diol (19d) Aqueous hydrochloric acid (10 mL, 1 N solution) was added to a solution of acetonide 18f (1.015 g, 1.735 mmol, 1.0 equiv) in THF (10 mL) and the reaction stirred at room temperature for 46 hours.", "It was then diluted with 14% aqueous sodium chloride (20 mL) and extracted with isopropyl acetate (3×20 mL).", "The combined organic phases were washed with saturated aqueous sodium bicarbonate (40 mL), 14% aqueous sodium chloride (40 mL), dried (Na2SO4) and concentrated to give 1.066 g of a colorless oil.", "Chromatography (40% to 100% ethyl acetate/heptane gradient) afforded 670 mg (71%) of the title compound as a foamy white solid.", "Data for 19d: Rf=0.31 (50% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.58-7.81 (m, 4H), 7.31-7.51 (m, 6H), 7.11 (t, J=7.91 Hz, 1H), 6.77 (t, J=7.62 Hz, 2H), 3.73-3.85 (m, 4H, contains s, 3H, 3.80), 3.47-3.62 (m, 2H), 3.27-3.40 (m, 1H), 2.90 (dd, J=6.15, 14.65 Hz, 1H), 2.74 (dd, J=6.15, 14.06 Hz, 1H), 2.50 (dd, J=8.20, 14.06 Hz, 1H), 2.34 (dd, J=7.91, 14.65 Hz, 1H), 1.83-2.09 (m, 2H), 1.64-1.82 (m, 3H), 1.48-1.62 (m, 2H), 1.14-1.46 (m, 4H), 0.96-1.11 (m, 9H); MS (ESI+) m/z 567.2 (M+Na+).", "Example 21d: (R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)butane-1,2-diol (19d) Triethylamine trihydrofluoride (0.16 mL, 0.98 mmol, 3.0 equiv) was added to an ice-cold solution of TBDMS ether 18d (253 mg, 0.327 mmol, 1.0 equiv) in THF (2 mL) with stirring, under nitrogen.", "The reaction was then warmed to 50° C. for 18 hours at which point it was shown to be complete by TLC.", "The reaction was quenched with saturated aqueous ammonium chloride (2 mL), diluted with water (2 mL) and extracted with ethyl acetate (3×4 mL).", "The combined organic phases were dried (Na2SO4) and concentrated to give 172 mg of a yellow oil.", "Chromatography (30% to 100% ethyl acetate/heptane gradient) afforded 99 mg (58%) of the title compound as a white, foamy solid.", "Data for 19d: Rf=0.26 (40% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.60-7.76 (m, 4H), 7.32-7.49 (m, 6H), 7.12 (t, J=7.78 Hz, 1H), 6.77 (t, J=7.78 Hz, 2H), 3.72-3.85 (m, 4H, contains s, 3H, 3.80), 3.48-3.59 (m, 2H), 3.27-3.39 (m, 1H), 2.90 (dd, J=6.13, 14.74 Hz, 1H), 2.74 (dd, J=6.04, 14.10 Hz, 1H), 2.50 (dd, J=8.24, 14.10 Hz, 1H), 2.34 (dd, J=7.78, 14.74 Hz, 1H), 1.84-2.08 (m, 2H), 1.80 (s, 2H), 1.72 (td, J=8.03, 16.34 Hz, 1H), 1.48-1.62 (m, 2H), 1.15-1.46 (m, 4H), 1.04 (s, 9H).", "Example 21e: (R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)butane-1,2-diol (19d) Pyridinium p-toluene sulfonate (5.52 g, 220 mmol) was added to a solution of TBDMS ether 18d (17 g, 221 mmol, 1.0 equiv) in ethanol (170 mL) and the reaction stirred at 40° C. for 56 hours.", "The reaction was then quenched with 2 mL of pyridine, and the resulting mixture concentrated to remove the organic solvents.", "Chromatography (15% to 40% ethyl acetate/heptane gradient) afforded 9.48 g (78%) of the title compound as a fluffy white solid.", "Data for 19d: Rf=0.26 (40% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.60-7.76 (m, 4H), 7.32-7.49 (m, 6H), 7.12 (t, J=7.78 Hz, 1H), 6.77 (t, J=7.78 Hz, 2H), 3.72-3.85 (m, 4H, contains s, 3H, 3.80), 3.48-3.59 (m, 2H), 3.27-3.39 (m, 1H), 2.90 (dd, J=6.13, 14.74 Hz, 1H), 2.74 (dd, J=6.04, 14.10 Hz, 1H), 2.50 (dd, J=8.24, 14.10 Hz, 1H), 2.34 (dd, J=7.78, 14.74 Hz, 1H), 1.84-2.08 (m, 2H), 1.80 (s, 2H), 1.72 (td, J=8.03, 16.34 Hz, 1H), 1.48-1.62 (m, 2H), 1.15-1.46 (m, 4H), 1.04 (s, 9H); MS (ESI+) m/z 567.3 (M+Na+).", "Example 22: (R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)-2-hydroxybutyl 2,4,6-triisopropylbenzenesulfonate (20d) Triethylamine (3.80 mL, 27.5 mmol, 4.0 equiv) and 4-dimethylaminopyridine (168 mg, 1.374 mmol, 0.2 equiv) were added to a solution of diol 19d (3.744 g, 6.872 mmol, 1.0 equiv) in anhydrous methylene chloride (30 mL) while stirring under nitrogen.", "The reaction was then cooled to 0° C. and 2,4,6-triisopropylbenzenesulfonyl chloride (2.498 g, 8.247 mmol, 1.2 equiv) added drop-wise as a solution in anhydrous methylene chloride (10 mL).", "After stirring at this temperature for 15 hours, the reaction was quenched with addition of saturated aqueous ammonium chloride (50 mL) and warmed to room temperature.", "The two phases were separated and the aqueous phase extracted with methylene chloride (3×50 mL).", "The combined organics were dried (MgSO4) and concentrated to give a dark yellow oil.", "Chromatography (0% to 20% ethyl acetate/heptane gradient) afforded 4.797 g (86%) of the title compound as a white, foamy solid.", "Data for 20d: Rf=0.46 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.55-7.73 (m, 4H), 7.29-7.46 (m, 6H), 7.22 (s, 2H), 7.11 (t, J=7.87 Hz, 1H), 6.75 (d, J=8.42 Hz, 2H), 4.15 (quin, J=6.68 Hz, 2H), 3.92 (dd, J=2.56, 9.89 Hz, 1H), 3.58-3.84 (m, 6H, contains s, 3H, 3.80), 2.81-3.03 (m, 2H), 2.71 (dd, J=6.23, 14.28 Hz, 1H), 2.46 (dd, J=8.06, 14.28 Hz, 1H), 2.26-2.40 (m, 1H), 1.81-2.09 (m, 3H), 1.69 (td, J=8.06, 16.11 Hz, 1H), 1.46-1.61 (m, 2H), 1.28 (m, 22H), 1.01 (s, 9H); MS (ESI+) m/z 828.8 (M+NH4+).", "Example 23a: tert-butyl(((1R,2R,3aS,9aS)-5-methoxy-1-(2-((R)-oxiran-2-yl)ethyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-yl)oxy)diphenylsilane (21c) Anhydrous potassium carbonate (1.592 g, 11.52 mmol, 2.0 equiv) was added to a solution of alcohol 20d (4.674 g, 5.762 mmol, 1.0 equiv) in anhydrous methanol (30 mL) and the mixture stirred under nitrogen for 1 hour.", "The reaction was then concentrated, the residue triterated in methylene chloride and filtered to remove the precipitate.", "The filtrate was concentrated, and the residue triterated in heptane, filtered to remove the precipitate and the filtrate concentrated to give 3.032 g (99%) of the title compound as a colorless oil.", "This material was deemed sufficiently pure to be carried forward.", "Data for 21c: Rf=0.50 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.59-7.77 (m, 4H), 7.32-7.49 (m, 6H), 7.11 (t, J=7.69 Hz, 1H), 6.76 (t, J=8.24 Hz, 2H), 3.72-3.86 (m, 4H, contains s, 3H, 3.80), 2.89 (dd, J=6.23, 14.65 Hz, 1H), 2.66-2.84 (m, 3H), 2.50 (dd, J=8.06, 14.28 Hz, 1H), 2.35-2.44 (m, 1H), 2.32 (dd, J=8.06, 15.01 Hz, 1H), 1.92-2.05 (m, 1H), 1.79-1.90 (m, 1H), 1.22-1.77 (m, 7H), 1.04 (s, 9H); MS (ESI+) m/z 549.5 (M+Na+).", "Example 23b: tert-butyl(((1R,2R,3aS,9aS)-5-methoxy-1-(2-((R)-oxiran-2-yl)ethyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-yl)oxy)diphenylsilane (21c) Anhydrous potassium carbonate (14.14 g, 102.3 mmol, 2.0 equiv) was added to a solution of alcohol 20d (41.5 g, 51.2 mmol, 1.0 equiv) in anhydrous methanol (415 mL) and the mixture stirred under nitrogen for 24 hours.", "The reaction was then quenched with 14% aqueous sodium chloride solution (800 mL) and extracted with heptane (3×800 mL).", "The combined organic phases were washed with 14% aqueous sodium chloride solution (800 mL), dried (MgSO4) and concentrated to give 26.3 g of a white waxy solid.", "Chromatography (0% to 10% ethyl acetate/heptane gradient) afforded 24.1 g (89%) of the title compound (21c) as a white waxy solid.", "The 24.1 g of 21c obtained above was warmed to a gentle reflux in heptane (240 mL, 10 volumes) until dissolved, cooled first to room temperature and then to −20° C. After standing at that temperature overnight, white crystals had formed that were filtered and dried under high vacuum to give 22.003 g of 21c (91% recovery).", "HPLC analysis showed that the white waxy solid 21c material had a purity of 91.07%, while the recrystallized 21c material had a purity of 96.59%.", "This recrystallization process was repeated again with 220 mL heptane giving 20.240 g (92% recovery) of 21c as a white crystalline product.", "HPLC analysis showed further enrichment to a purity of 97.46%.", "The 20.240 g of 21c obtained above was warmed to a gentle reflux in heptane (200 mL, 10 volumes) until dissolved, cooled first to room temperature and then to −20° C. After standing at that temperature overnight, white crystals had formed which were filtered and dried at 40° C. under high vacuum to give 19.308 g of 21c (95% recovery).", "HPLC analysis showed further enrichment to a purity of 98.19%.", "Data for 21c: Rf=0.50 (20% EtOAc/heptane); mp=78.5-79.5° C.; 1H NMR (400 MHz, CHLOROFORM-d) δ 7.59-7.77 (m, 4H), 7.32-7.49 (m, 6H), 7.11 (t, J=7.69 Hz, 1H), 6.76 (t, J=8.24 Hz, 2H), 3.72-3.86 (m, 4H, contains s, 3H, 3.80), 2.89 (dd, J=6.23, 14.65 Hz, 1H), 2.66-2.84 (m, 3H), 2.50 (dd, J=8.06, 14.28 Hz, 1H), 2.35-2.44 (m, 1H), 2.32 (dd, J=8.06, 15.01 Hz, 1H), 1.92-2.05 (m, 1H), 1.79-1.90 (m, 1H), 1.22-1.77 (m, 7H), 1.04 (s, 9H); IR (KBr pellet) 3427.7 (s), 3071.0 (m), 3049.8 (m), 2959.6 (s), 2928.6 (s), 2858.7 (m), 1797.0 (w), 1584.5 (s), 1473.4 (s), 1454.6 (m), 1428.1 (m), 1264.4 (s), 1109.4 (s), 1022.0 (m), 822.6 (w), 783.1 (w), 743.9 (w), 703.8 (s), 613.5 (w) cm−1; MS (ESI+) m/z 549.5 (M+Na+); HPLC, Regis (S,S) Whelk-01 column (4.6×250 mm2), 5 μm; flow rate 1.0 mL/min; 210 nm; mobile phase 90:10 heptane/MTBE, 21c retention time: 20.14 min.", "Example 24a: (S)-1-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)heptan-3-ol (22b) A slurry of epoxide 21c (56 mg, 0.11 mmol, 1.0 equiv) and copper(I) iodide (4.0 mg, 0.021 mmol, 0.2 equiv) in anhydrous ether (1.0 mL) that had been cooled to −78° C. was treated drop-wise with n-butyllithium (0.28 mL, 0.70 mmol, 6.6 equiv, 2.5 M in hexanes) and the resulting mixture slowly warmed to −40° C. over 30 minutes while stirring under nitrogen.", "The cloudy yellow mixture turned almost black in color during this time and the reaction was shown to be complete by TLC.", "This was then quenched with addition of saturated aqueous ammonium chloride (5 mL) and warmed to room temperature.", "The deep blue aqueous layer was extracted with ethyl acetate (3×5 mL).", "The combined organic phases were washed with brine, dried (MgSO4) and concentrated to give 60 mg of a colorless oil.", "Chromatography (0% to 20% ethyl acetate/heptane gradient) afforded 52 mg (84%) of the title compound as a colorless oil.", "Data for 22b: Rf=0.42 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.59-7.77 (m, 4H), 7.31-7.51 (m, 6H), 7.11 (t, J=7.81 Hz, 1H), 6.71-6.81 (m, 2H), 3.73-3.85 (m, 4H, contains s, 3H, 3.80), 3.44 (br.", "s., 1H), 2.91 (dd, J=6.25, 14.45 Hz, 1H), 2.75 (dd, J=6.25, 14.45 Hz, 1H), 2.50 (dd, J=8.20, 14.06 Hz, 1H), 2.32 (dd, J=8.01, 14.65 Hz, 1H), 1.82-2.05 (m, 2H), 1.65-1.77 (m, 1H), 1.50-1.62 (m, 2H), 1.15-1.47 (m, 13H), 1.04 (s, 9H), 0.92 (t, J=7.03 Hz, 3H); MS (ESI+) m/z 607.2 (M+Na+).", "Example 24b: (S)-1-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)hexan-3-yl acetate (22c) A slurry of epoxide 21c (3.3 g, 6.3 mmol, 1.0 equiv) and copper(I) iodide (148 mg, 0.78 mmol, 0.013 equiv) in methyl tert-butyl ether (35.0 mL) that had been cooled to −40° C. was treated drop-wise with n-butyllithium (11.4 mL, 17.1 mmol, 2.74 equiv, 1.5 M solution in hexanes) and the resulting mixture stirred under nitrogen.", "The cloudy yellow mixture turned almost black in color during this time and the reaction was shown to be complete by TLC.", "This was then treated with addition of ethyl acetate and warmed to room temperature then quenched with aqueous ammonium chloride (75 mL).", "The deep blue aqueous layer was extracted with ethyl acetate (2×75 mL).", "The combined organic phases were concentrated to give a colorless oil.", "Chromatography (0% to 2% ethyl acetate/heptane gradient) afforded 3.3 g (88%) of the title compound as a colorless oil.", "Data for 22c: Rf=0.64 (20% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.60-7.73 (m, 4H), 7.31-7.48 (m, 6H), 7.11 (t, J=7.69 Hz, 1H), 6.77 (dd, J=7.87, 16.30 Hz, 2H), 4.80 (d, J=5.86 Hz, 1H), 3.68-3.83 (m, 4H), 2.87 (dd, J=6.23, 14.65 Hz, 1H), 2.73 (dd, J=6.23, 13.92 Hz, 1H), 2.48 (dd, J=8.24, 14.10 Hz, 1H), 2.30 (dd, J=8.06, 15.01 Hz, 1H), 1.89-2.06 (m, 4H), 1.74-1.87 (m, 1H), 1.61-1.74 (m, 1H), 1.13-1.60 (m, 14H), 1.03 (s, 9H), 0.84-0.94 (m, 3H); MS (ESI+) m/z 649.4 (M+Na+).", "Example 24c: S)-1-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)heptan-3-ol (22b) To a solution of acetate 22c (3.3 g, 5.3 mmol, 1 equiv) in methanol (90 mL) was added anhydrous potassium carbonate (3.5 g, 25.4 mmol, 4.8 equiv) and DI water (10 mL).", "The reaction was stirred at 60° C. for three hours and then cooled to room temperature overnight.", "At that point the reaction was deemed complete by TLC and the solvent was removed under reduced pressure.", "The crude residue was extracted with dichloromethane (100 mL), the organic layer passed through filter paper to remove the resulting white solid, and the filtrate was concentrated to give 3.12 g of a pale yellow solid (quantitative).", "Data for 22c: Rf=0.42 (20% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.59-7.77 (m, 4H), 7.31-7.51 (m, 6H), 7.11 (t, J=7.81 Hz, 1H), 6.71-6.81 (m, 2H), 3.73-3.85 (m, 4H, contains s, 3H, 3.80), 3.44 (br.", "s., 1H), 2.91 (dd, J=6.25, 14.45 Hz, 1H), 2.75 (dd, J=6.25, 14.45 Hz, 1H), 2.50 (dd, J=8.20, 14.06 Hz, 1H), 2.32 (dd, J=8.01, 14.65 Hz, 1H), 1.82-2.05 (m, 2H), 1.65-1.77 (m, 1H), 1.50-1.62 (m, 2H), 1.15-1.47 (m, 13H), 1.04 (s, 9H), 0.92 (t, J=7.03 Hz, 3H).", "Example 25: (1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-ol (23a) A solution of n-butyllithium (6.80 mL, 17.0 mmol, 8.2 equiv, 2.5 M in hexanes) was added drop-wise to a −20° C. solution of diphenylphosphine (2.714 g, 14.58 mmol, 7.0 equiv) in THF (25 mL), under nitrogen, and stirred at that temperature for 30 minutes.", "Then, approximately ⅔ of this solution was cannulated into a solution of methyl ether 22b in THF (5 mL) at room temperature and the resultant mixture was heated to reflux for 2 hours while stirring, under nitrogen.", "The reaction was then cooled to room temperature, the remainder of the n-butyllithium/diphenylphosphine solution was cannulated over and the reaction was heated back to reflux for 17 hours.", "At this point, the reaction was cooled in an ice bath and cautiously quenched with addition of 3 M aqueous hydrochloric acid until the pH is acidic.", "The organic layer was separated and the aqueous phase extracted with ethyl acetate (3×30 mL).", "The combined organic phases were washed with brine, dried (Na2SO4) and concentrated to give 4.3 g of a colorless oil.", "Chromatography (0% to 40% ethyl acetate/heptane gradient) afforded 1.101 g (93%) of the title compound as a white, foamy solid.", "Data for 23a: Rf=0.29 (20% EtOAc/heptane); 1H NMR (400 MHz, CDCl3) δ 7.70 (dd, J=7.32, 17.94 Hz, 4H), 7.32-7.51 (m, 6H), 6.96-7.06 (m, 1H), 6.75 (d, J=7.32 Hz, 1H), 6.67 (d, J=8.06 Hz, 1H), 3.82 (q, J=6.84 Hz, 1H), 3.49 (br.", "s., 1H), 2.84 (dd, J=6.23, 14.65 Hz, 1H), 2.75 (dd, J=5.86, 14.28 Hz, 1H), 2.51 (dd, J=8.24, 14.10 Hz, 1H), 2.34 (dd, J=7.87, 14.46 Hz, 1H), 2.02 (dd, J=7.87, 15.93 Hz, 1H), 1.91 (td, J=6.36, 12.54 Hz, 1H), 1.73 (quin, J=8.06 Hz, 1H), 1.50-1.65 (m, 2H), 1.15-1.49 (m, 13H), 1.07 (s, 9H), 0.87-0.97 (m, 3H); MS (ESI+) m/z 593.3 (M+H+).", "Example 26a: (1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol (24a) Tetra-n-butylammonium fluoride (2.90 mL, 2.90 mmol, 1.5 equiv, 1.0 M solution in THF) was added to a solution of TBDPS-ether 23a (1.083 g, 1.897 mmol, 1.0 equiv) in anhydrous THF, under nitrogen, and the mixture stirred at room temperature for 22 hours.", "Analysis by TLC indicated that the reaction was not complete, so it was fitted with a water-cooled condenser and heated to 50° C. for 3.5 hours.", "The reaction was then quenched with 14% aqueous sodium chloride (20 mL) and extracted with ethyl acetate (3×15 mL).", "The combined organic phases were dried (Na2SO4) and concentrated to give 1.375 g of an amber oil.", "Chromatography (12% to 100% ethyl acetate/heptane gradient) afforded 484 mg (77%) of the title compound as a white foam.", "Data for 24a: Rf=0.12 (50% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 6.95 (t, J=7.51 Hz, 1H), 6.66 (dd, J=7.69, 13.55 Hz, 2H), 6.59 (br.", "s., 1H), 3.61-3.77 (m, 1H), 3.57 (br.", "s., 1H), 3.02 (br.", "s., 1H), 2.58-2.76 (m, 2H), 2.34-2.56 (m, 3H), 2.17-2.30 (m, 1H), 2.03-2.14 (m, 1H), 1.79-1.93 (m, 1H), 1.64 (d, J=7.32 Hz, 2H), 1.38-1.56 (m, 4H), 1.16-1.37 (m, 7H), 1.10 (q, J=10.62 Hz, 1H), 0.85-0.96 (m, 3H); MS (ESI+) m/z 355.2 (M+Na+).", "Example 26b: (1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol (24a) Triethylamine Trihydrofluoride (4.57 g, 28.3 mmol, 3.7 equiv) was added in portions to a solution of TBDPS-ether 23a (4.4 g, 7.7 mmol, 1.0 equiv) in anhydrous THF (45 mL), under nitrogen, and the mixture stirred at 62° C. for 5 days.", "Analysis by TLC indicated that the reaction was complete.", "The reaction was then quenched with 10% aqueous potassium bicarbonate (35 mL) and extracted with ethyl acetate (2×35 mL).", "The combined organic phases were concentrated to give 5.37 g of oil.", "Chromatography (25% to 100% ethyl acetate/heptane gradient) afforded 1.84 g (72%) of the title compound as white foam.", "Data for 24a: Rf=0.12 (50% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ 6.95 (t, J=7.51 Hz, 1H), 6.66 (dd, J=7.69, 13.55 Hz, 2H), 6.59 (br.", "s., 1H), 3.61-3.77 (m, 1H), 3.57 (br.", "s., 1H), 3.02 (br.", "s., 1H), 2.58-2.76 (m, 2H), 2.34-2.56 (m, 3H), 2.17-2.30 (m, 1H), 2.03-2.14 (m, 1H), 1.79-1.93 (m, 1H), 1.64 (d, J=7.32 Hz, 2H), 1.38-1.56 (m, 4H), 1.16-1.37 (m, 7H), 1.10 (q, J=10.62 Hz, 1H), 0.85-0.96 (m, 3H); MS (ESI+) m/z 355.2 (M+Na+).", "Example 26c: (1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol (24a) Hydrochloric acid (12 mL, 3 N) was added to a solution of TBDPS-ether 23a (4.4 g, 7.7 mmol) in methanol (40 mL) and the mixture stirred at 62° C. for 22 hrs.", "Analysis by TLC indicated that the reaction was complete.", "The reaction was concentrated to give 4.95 g of colorless oil.", "Chromatography (5% to 40% ethyl acetate/heptane gradient) afforded 1.48 g (58%) of the title compound as white foam.", "Data for 24a: Rf=0.12 (50% EtOAc/heptane); 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 6.91-6.99 (m, 1H), 6.66-6.72 (m, 1H), 6.61-6.66 (m, 1H), 3.63-3.73 (m, 1H), 3.53-3.63 (m, 1H), 2.57-2.75 (m, 2H), 2.33-2.51 (m, 2H), 2.16-2.30 (m, 1H), 2.05-2.15 (m, 1H), 1.79-1.92 (m, 1H), 1.18-1.71 (m, 13H), 1.04-1.15 (m, 1H), 0.83-0.93 (m, 3H); MS (ESI+) m/z 355.2 (M+Na+).", "Example 27: ethyl 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetate(25a) Ethyl bromoacetate was added drop-wise to a slurry of benzindene triol 24a (500 mg, 1.504 mmol, 1.0 equiv), anhydrous potassium carbonate (312 mg, 2.26 mmol, 1.5 equiv) and anhydrous potassium iodide (25 mg, 0.15 mmol, 0.1 equiv) in acetone (20 mL) and the reaction was heated to reflux while stirring, under nitrogen for 16 hours.", "The reaction was then cooled to room temperature, diluted with heptane (10 mL) and filtered through celite.", "The celite was rinsed with ethyl acetate (3×30 mL) and the filtrate was concentrated to give a pale oil.", "Chromatography (10% to 80% ethyl acetate/heptane gradient) afforded 610 mg (96%) of the title compound as a colorless oil.", "Data for 25a: Rf=0.15 (50% EtOAc/heptane); 1H NMR 1H NMR (400 MHz, CDCl3) δ 7.07 (t, J=7.87 Hz, 1H), 6.81 (d, J=7.32 Hz, 1H), 6.64 (d, J=7.69 Hz, 1H), 4.62 (s, 2H), 4.27 (q, J=7.32 Hz, 2H), 3.76 (dt, J=6.04, 9.61 Hz, 1H), 3.55-3.70 (m, J=4.40 Hz, 1H), 2.89 (dd, J=5.86, 14.65 Hz, 1H), 2.76 (dd, J=6.23, 14.28 Hz, 1H), 2.56 (dd, J=6.59, 15.01 Hz, 1H), 2.46 (dd, J=6.59, 14.28 Hz, 1H), 2.11-2.34 (m, 4H), 1.89 (tt, J=6.50, 9.98 Hz, 1H), 1.24-1.75 (m, 16H), 1.12-1.23 (m, 1H), 0.84-0.99 (m, 3H); MS (ESI+) m/z 419.3 (M+H+).", "Example 28: 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid (I) Potassium hydroxide (5.623 g in 19 mL water, 30% solution in water, 100.2 mmol, 5.0 equiv) was added to a solution of ethyl ester 25a (8.390 g, 20.04 mmol, 1.0 equiv) in ethanol (100 mL) and stirred at room temperature, under nitrogen for 90 minutes.", "The reaction was then concentrated under reduced pressure to remove the ethanol, diluted with water (50 mL) and extracted with ethyl acetate (50 mL) to remove organic impurities.", "The aqueous layer was acidified to pH 2-3 by addition of 3 N aqueous hydrochloric acid and extracted with ethyl acetate (3×100 mL).", "The combined organic phases were treated with activated charcoal (800 mg) and heated to reflux for 1 hour, cooled to room temperature, filtered through celite and concentrated to give 8.2 g of the title compound as an off-white solid.", "This material was moved forward to the next step crude and was not characterized further.", "Data for I: Rf=0.27 (90:10:1 methylene chloride/methanol/acetic acid).", "Example 29: 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid diethanolamine salt (I, diethanolamine salt) A solution of treprostinil I (7.83 g, 20.1 mmol, 1.0 equiv) in ethyl acetate (250 mL) was treated with a solution of diethanolamine (2.11 g, 20.1 mmol, 1.0 equiv) in anhydrous ethanol (32 mL) and the resulting slurry heated to reflux for 15 minutes, at which point everything went into solution.", "This was allowed to slowly cool to room temperature over 18 hours resulting in formation of a white crystalline solid.", "The solid was filtered, rinsed with ethyl acetate (2×100 mL), and dried for 24 hours at 50° C. under vacuum to give 7.552 g (76%) of the title compound as a white powder.", "Example 30: 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid (I) A solution of the diethanolamine salt of Formula I (5.775 g, 11.65 mmol, 1.0 equiv) in water (60 mL) was treated with aqueous hydrochloric acid (2.11 g, 20.1 mmol, 1.0 equiv) in anhydrous ethanol (32 mL) and the resulting slurry heated to reflux for 15 minutes, at which point everything went into solution.", "This was allowed to slowly cool to room temperature over 18 hours resulting in formation of a white crystalline solid.", "The solid was filtered, rinsed with ethyl acetate (2×100 mL), and dried for 24 hours at 50° C. under vacuum to give 7.552 g (76%) of the title compound as a white powder.", "Data for I: 1H NMR (400 MHz, CHLOROFORM-d) δ 7.07 (t, J=7.88 Hz, 1H), 6.82 (d, J=7.69 Hz, 1H), 6.68 (d, J=8.43 Hz, 1H), 4.58-4.72 (m, 2H), 4.40 (br.", "s., 3H), 3.73 (dt, J=6.23, 9.34 Hz, 1H), 3.64 (d, J=3.66 Hz, 1H), 2.76 (ddd, J=6.23, 14.20, 19.87 Hz, 2H), 2.61 (dd, J=6.04, 14.84 Hz, 1H), 2.48 (dd, J=6.23, 14.29 Hz, 1H), 2.20-2.36 (m, 1H), 2.10-2.20 (m, 1H), 1.82-1.98 (m, 1H), 1.52-1.76 (m, 4H), 1.40-1.52 (m, 3H), 1.21-1.40 (m, 6H), 1.08-1.21 (m, 1H), 0.92 (t, J=6.60 Hz, 3H); MS (ESI+) m/z 413.2 (M+Na+); HPLC, Synergi Hydro RP column (4.6×250 mm2), 5 mm; flow rate 2.0 mL/min; 277 nm; mobile phase water (60%):acetonitrile (40%): trifluoroacetic acid (0.1%); retention time, 39.12 min (98.0%, I), retention time, 41.05 min (1.2%, 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((R)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid).", "Example 31a: 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid sodium salt (I, sodium salt) A solution of the compound of Formula I (1 equiv) will be dissolved in distilled ethanol at 30-50° C. and then cooled to 15-25° C. The solution will then be neutralized with a solution of sodium hydroxide (1 molar solution in ethanol) using a glass electrode to detect the point of equivalence (to pH value 9.8-10.2).", "The solution will be filtered, and the filtrate concentrated to give the crude sodium salt of the compound of Formula I.", "This may optionally be recrystallized from acetone/water or another appropriate solvent system to furnish a pure form of the title compound.", "Example 31b: 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid sodium salt (I, sodium salt) A solution of ethyl ester 25a (1 equiv.)", "will be dissolved in distilled methanol and aq.", "NaOH (1 equiv., 1 molar solution) will be added and stirred at an appropriate temperature until the salt formation is complete.", "The reaction will then be concentrated to give crude sodium salt of the compound of Formula I.", "This may optionally be recrystallized from acetone/water or another appropriate solvent system to furnish a pure form of the title compound.", "OTHER EMBODIMENTS It is to be understood that while the invention has been described in conjunction with the detailed description thereof, the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims.", "Other aspects, advantages, and modifications are within the scope of the following claims." ] ]
Patent_15874093
[ [ "Depth Sensing Camera Glasses With Gesture Interface", "Glasses wearable by a user and responsive to gestural commands and method for operating the glasses to control one or more devices.", "In a preferred form, the glasses include a plurality of spaced, depth cameras that react to a user's hand command based, at least in part, on the distance of the hand from the depth camera.", "The depth cameras can recognize multiple distances and gesture movement, as well as hand configuration." ], [ "1.A method of operating glasses wearable by a user to control operation of one or more devices, comprising: making a first gestural command to activate a first response from one or more depth sensors embedded in the glasses; operating a first device comprising an RGB camera to acquire an image operatively connected to said glasses based at least in part on said first response to said first gestural command; making a second gestural command to activate a second response from one or more depth sensors embedded in the glasses; and operating a second device operatively connected to said glasses based at least in part on said second response to said second gestural command.", "2.The method of claim 1, wherein said second device comprises a radio and said second response causes transmission of said image.", "3.The method of claim 1, wherein said second response activates a software function.", "4.The method of claim 1, one of said gestural commands being a hand command dependent upon distance of the hand from at least one of the depth sensors.", "5.The method of claim 1, said RGB camera being integral with said glasses.", "6.The method of claim 1, said depth sensor being embedded in the glasses near an ear of the user and side facing.", "7.The method of claim 1, said depth sensor being embedded in the glasses near the nose of the user and front facing.", "8.The method of claim 1, said depth camera comprising on one or more of the following types: stereo triangulation; sheet of light triangulation; structured light; time-of-flight; interferometry; or coded aperture.", "9.The method of claim 1, one of said depth sensors comprising multiple depth sensors spaced along a portion of the glasses.", "10.The method of claim 1, wherein said second device comprising a wake surf boat and said second response controls a function of the wake surf boat.", "11.The method of claim 1, wherein said second device comprising a smart phone and said second response controls said smart phone.", "12.The method of claim 1, wherein said second device comprising another camera wirelessly connected to the glasses and said second response controls said other camera.", "13.Glasses wearable by a user and responsive to gestural commands, comprising: a plurality of spaced, depth cameras integral with the glasses; at least one of the depth cameras being configured to react to a user hand first gestural command, an RGB camera operatively connected to said one depth camera to acquire an image in reaction to said first gestural command said first gestural command being defined in part by the distance of the user's hand from said one depth camera.", "14.The glasses of claim 13, including lenses for projecting augmented reality information to a user.", "15.The glasses of claim 13, including lenses for projecting virtual reality information to a user.", "16.The glasses of claim 13, said depth camera comprising at least two, spaced apart structured light sources and at least one structured light receiver proximate said transmitters.", "17.A method of operating glasses worn by a user to control operation of one or more devices, comprising: making a first gestural user hand command to activate a first response from one or more depth sensors embedded in the glasses, wherein said first command comprises said hand positioned approximately a first distance from a first depth sensor; operating a first device comprising a camera to acquire an image operatively connected to said glasses based at least in part on said depth sensor response to said first gestural command; making a second gestural user hand command to activate a second response from said first depth sensors embedded in the glasses, wherein said second command comprises said hand positioned approximately a second distance from said first depth sensor.", "18.The method of claim 17, said first gestural user hand command comprising a swipe in a first plane generally along said first distance.", "19.The method of claim 18, said first gestural user hand command comprising a swipe in a first direction generally in said first plane.", "20.The method of claim 18, said depth sensor comprising two depth sensors spaced along the glasses, said first plane being approximately said first distance from each depth sensor." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>The problems outlined above are addressed by the methods and glasses of the present invention.", "In a preferred form, a method of operating glasses wearable by a user to control operation of one or more devices includes making a first gestural command to activate a first response from one or more depth sensors embedded in the glasses to operate a first device.", "In one form, the first device comprises an RGB camera to acquire an image operatively connected to the glasses based on the first response to the first gestural command.", "After the first command, the method includes making a second gestural command to activate a second response from one or more depth sensors embedded in the glasses and operating a second device operatively connected to said glasses based on the second response to the second gestural command.", "In this preferred method, the depth camera comprises one or more of the following types of sensors: stereo triangulation; sheet of light triangulation; structured light; time-of-flight; interferometry; or coded aperture.", "In this preferred method, the second device can be a number of different types of devices.", "For example, if the second device comprises a radio, the second response causes transmission of an acquired image.", "If the second device comprises a smart phone, the second response causes a software function on the smart phone to operate.", "In a preferred embodiment, glasses wearable by a user and responsive to gestural commands is provided.", "The glasses include a plurality of spaced, depth cameras integral with the glasses, and at least one of the depth cameras being configured to react to a user hand first gestural command.", "The glasses include an RGB camera operatively connected to a depth camera to acquire an image in reaction to the first gestural command.", "The first gestural command is defined in part by the distance of the user's hand from the depth camera.", "The lenses of the glasses can be clear, or configured for projecting augmented reality information (AR) to a user or configured for projecting virtual reality (VR) information to a user.", "In another preferred method, glasses are operated by a user to control operation of one or more devices by making a first gestural user hand command to activate a first response from one or more depth sensors embedded in the glasses, the first command includes the hand positioned approximately a first distance from a first depth sensor.", "The method includes operating a first device such as a camera to acquire an image operatively connected to the glasses where the operation is based at least in part on the depth sensor response to the first gestural command.", "The method also includes making a second gestural user hand command to activate a second response from said first depth sensors embedded in the glasses.", "The second command includes the user's hand positioned approximately a second distance from the first depth sensor." ], [ "PRIORITY The present application is a continuation from U.S. Ser.", "No.", "13/774,710 filed Feb. 22, 2013 which claims priority to U.S. 61/602,390 filed Feb. 23, 2012.The disclosures therein are incorporated by reference herein.", "BACKGROUND 1.Field of the Invention The present invention relates to glasses having depth sensors that facilitate gestural commands.", "In preferred forms, the glasses hereof include depth sensors to permit more accurate and varied gestural commands to cameras, smart phones, and other devices.", "2.Description of the Related Art A number of companies make glasses for augmented reality, such as Vuzix, Atheer, Meta, Microsoft and Vue.", "Further, a number of companies make virtual reality “head mounted displays” (HMD), such as Occulus, Sony and Vive.", "Still other companies, such as Google Pixel and Apple have developed augmented reality (AR) platforms that can be used in conjunction with headsets that hold an AR capable smart phone.", "Photo sharing sites have arisen where web based photo repositories (Photobucket) share photos of an event with authorized users.", "Examples include Flickr, Photobucket, Picasa, Shutterfly, Beamr and Snapfish.", "Further, social networks such as Facebook and Google+ allow groups to post photos of an event and share photographs with friends.", "Such photo repositories and social networks are useful in sharing an event with friends, but are limited in realism and interaction.", "Further, many social networks operate as photo repositories and traditional photo repositories have become social networks—blurring the distinction between them.", "Further, photo improvement sites have become common.", "For example, Instagram, Camera+, and Pinterest.", "Several companies have taken photo sharing in the direction of creating and sharing “stories” which includes acquiring and sharing photos or video at an event and sharing with selected friends in a social network.", "Instagram and Snapchat have developed this stories genre of photo sharing.", "There is a need for a head mounted displays (HMD's), e.g.", "glasses, that can acquire photos and videos and share such “images” with a social network or publish for general consumption, such as “stories.” Additionally, there is a need to control other devices from an HMD.", "Further, there is a need for gesture based interfaces on such HMD's particularly in active environments such as sporting activities or sterile environments.", "A common approach to interfaces for HMD's is to use voice commands or push buttons.", "With the rise of augmented and virtual reality HMD's, such approaches are not always appropriate.", "For example, in an environment requiring silence, voice commands are inappropriate.", "Related patents and applications describe various improvements on location based experiences, for example: U.S. Pat.", "Nos.", "7,855,638 and 7,518,501 and U.S.", "Publication Nos.", "2011/0282799, 2007/0018880, 2012/0007885, and 2008/0259096 (sometimes referred to herein as “Related Patents”).", "Additional patents and applications of interest include 2014/0152539; 20130336524; U.S. Pat.", "Nos.", "8,169,421; 9,400,559; and 9,417,706.All references cited herein are incorporated by reference to the maximum extent allowable by law, but such incorporation should not be construed as an admission that a reference is prior art.", "SUMMARY The problems outlined above are addressed by the methods and glasses of the present invention.", "In a preferred form, a method of operating glasses wearable by a user to control operation of one or more devices includes making a first gestural command to activate a first response from one or more depth sensors embedded in the glasses to operate a first device.", "In one form, the first device comprises an RGB camera to acquire an image operatively connected to the glasses based on the first response to the first gestural command.", "After the first command, the method includes making a second gestural command to activate a second response from one or more depth sensors embedded in the glasses and operating a second device operatively connected to said glasses based on the second response to the second gestural command.", "In this preferred method, the depth camera comprises one or more of the following types of sensors: stereo triangulation; sheet of light triangulation; structured light; time-of-flight; interferometry; or coded aperture.", "In this preferred method, the second device can be a number of different types of devices.", "For example, if the second device comprises a radio, the second response causes transmission of an acquired image.", "If the second device comprises a smart phone, the second response causes a software function on the smart phone to operate.", "In a preferred embodiment, glasses wearable by a user and responsive to gestural commands is provided.", "The glasses include a plurality of spaced, depth cameras integral with the glasses, and at least one of the depth cameras being configured to react to a user hand first gestural command.", "The glasses include an RGB camera operatively connected to a depth camera to acquire an image in reaction to the first gestural command.", "The first gestural command is defined in part by the distance of the user's hand from the depth camera.", "The lenses of the glasses can be clear, or configured for projecting augmented reality information (AR) to a user or configured for projecting virtual reality (VR) information to a user.", "In another preferred method, glasses are operated by a user to control operation of one or more devices by making a first gestural user hand command to activate a first response from one or more depth sensors embedded in the glasses, the first command includes the hand positioned approximately a first distance from a first depth sensor.", "The method includes operating a first device such as a camera to acquire an image operatively connected to the glasses where the operation is based at least in part on the depth sensor response to the first gestural command.", "The method also includes making a second gestural user hand command to activate a second response from said first depth sensors embedded in the glasses.", "The second command includes the user's hand positioned approximately a second distance from the first depth sensor.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1a is a perspective view of a Plaza used as an example herein, and FIG.", "1b is a plan view of the Plaza of FIG.", "1a; FIG.", "2 is a front elevational view of a mobile device in a preferred embodiment; FIG.", "3 is a functional diagram of a network system in accordance with the present invention; FIG.", "4 is a front elevational view of the mobile device of FIG.", "2 depicting functional objects; FIG.", "5 is a back elevational view of the device of FIGS.", "2 and 4; FIG.", "6 is a functional hardware diagram of the device of FIGS.", "2, 4, and 5; FIG.", "7 is a front elevational view of the device of FIG.", "2 showing a first example; FIG.", "8 is a front elevational view of the device of FIG.", "2 showing a second example; FIG.", "9 is a front elevational view of the device of FIG.", "2 showing a third example; FIG.", "10 is a perspective view of another mobile device of the present invention; FIG.", "11A is a perspective, aerial view of a portion of a city where a low resolution wire frame is depicted; FIG.", "11B is a perspective, aerial view of the same portion of a city where a refined resolution is depicted; FIG.", "11C is a perspective, aerial view of the same portion of a city where a detailed resolution is depicted; FIG.", "11D is a perspective, aerial view of the same portion of a city where a fine, photorealistic resolution is depicted; FIG.", "12 is a table of EXIF metadata for an acquired image; FIGS.", "13a and 13b are diagrams showing Photogrammetry basic theory; FIG.", "14 is a schematic depicting image alignment and registration; FIG.", "15 is a schematic depicting three different views of a target; FIG.", "16A illustrates a conventional camera; FIG.", "16B illustrates the geometry of a plenoptic camera; FIG.", "17 is a perspective view of a room having an embodiment of an immersive environment; FIG.", "18 is a perspective view of another room, specifically a wedding chapel, illustrating another environment; FIG.", "19 is a perspective view of another embodiment of the glasses of FIG.", "10; FIG.", "20 is a side elevation of another embodiment of glasses in accordance with the invention; FIG.", "21 is a front elevation of the glasses of FIG.", "20; FIG.", "22 is a chart showing the Field of View (FOV) of the glasses of FIGS.", "20 and 21; FIG.", "23 is a diagram showing gesture direction versus FOV of FIG.", "22 for the glasses of FIGS.", "20 and 21; and FIG.", "24 is a perspective view of the rear of a wake surf boat controllable by glasses hereof.", "DESCRIPTION OF PREFERRED EMBODIMENTS I. Overview In an exemplary form, a 3D model or “virtual model” is used as a starting point, such as the image of the plaza of FIG.", "1a.", "Multiple users (or a single user taking multiple pictures) take pictures (images) of the plaza from various locations, marked A-E in FIG.", "1b using a mobile device, such as smart phone 10 shown in FIG.", "3.Each image A-E includes not only the image, but metadata associated with the image including EXIF data, time, position, and orientation.", "In this example, the images and metadata are uploaded as they are acquired to a communication network 205 (e.g., cell network) connected to an image processing server 211 (FIG.", "3).", "In some embodiments, the mobile device also includes one or more depth cameras as shown in FIG.", "2.The image processing server 211 uses the network 205 and GPS information from the phone 10 to process the metadata to obtain very accurate locations for the point of origin of images A-E.", "Using image matching and registration techniques the images are stitched together to form mosaics and panoramas, and to refine a 3D model of the plaza.", "In refining the 3D model of the plaza, image recognition techniques may remove people from the images to focus on building a very accurate 3D model of the plaza without clutter and privacy issues.", "The resulting “environment” is an accurate 3D model of the plaza that can be recreated and viewed from any location in the plaza and user selected orientation from the user-chosen location.", "Further, many locations in the plaza have images, mosaics or panoramas of stitched images associated with the location or can be created from images associated with nearby locations.", "In one example, a user remote from the plaza at the time of an event can participate in the event by accessing the experience platform 207 and viewing the plaza in essentially real time.", "All or selected participants in the event can be retained in the images, and even avatars employed to represent participants at the event.", "The remote user, therefore can observe the plaza during the event selecting a virtual view of the plaza or photographic view of the plaza during the event.", "In another example, the plaza described above for an event becomes newsworthy for the event.", "Remote users or a news organization can replay the event using the historical images for the event accessed from the experience platform.", "In still another example, a user physically attending the event at the plaza can participate by accessing the experience platform 207 and identifying participants in the event using augmented reality and/or object related content.", "II.", "Explanation of terms As used herein, the term “image” refers to one or a series of images taken by a camera (e.g., a still camera, digital camera, video camera, camera phone, etc.)", "or any other imaging equipment.", "The image is associated with metadata, such as EXIF, time, location, tilt angle, and orientation of the imaging device (e.g., camera) at the time of image capture.", "Depth camera information and audio can also be considered an image or part of an image.", "As used herein, the term “point of interest” refers to any point in space specified by a user in an image.", "By way of example, the point of interest in an image can be an observation deck or a roof of a tower, an antenna or a window of a building, a carousel in a park, etc.", "“Points of interest” are not limited to only stationary objects but can include moving objects as well.", "The most common positioning technology is GPS.", "As used herein, GPS—sometimes known as GNSS—is meant to include all of the current and future positioning systems that include satellites, such as the U.S. Navistar, GLONASS, Galileo, EGNOS, WAAS, MSAS, BeiDou Navigation Satellite System (China), QZSS, etc.", "The accuracy of the positions, particularly of the participants, can be improved using known techniques, often called differential techniques, such as WAAS (wide area), LAAS (local area), Carrier-Phase Enhancement (CPGPS), Space Based Augmentation Systems (SBAS); Wide Area GPS Enhancement (WAGE), or Relative Kinematic Positioning (RKP).", "Even without differential correction, numerous improvements are increasing GPS accuracy, such as the increase in the satellite constellation, multiple frequencies (L1, L2, L5), modeling and AGPS improvements, software receivers, and ground station improvements.", "Of course, the positional degree of accuracy is driven by the requirements of the application.", "In the golf example used to illustrate a preferred embodiment, sub five meter accuracy provided by WAAS with Assisted GPS would normally be acceptable.", "In building a model in accordance with the present invention, AGPS, WAAS, and post processing using time and differential correction can result in submeter position accuracy.", "Further, some “experiences” might be held indoors and the same message enhancement techniques described herein used.", "Such indoor positioning systems include AGPS, IMEO, Wi-Fi (Skyhook), WIFISLAM, Cell ID, pseudolites, repeaters, RSS on any electromagnetic signal (e.g.", "TV) and others known or developed.", "The term “geo-referenced” means a message fixed to a particular location or object.", "Thus, the message might be fixed to a venue location, e.g., golf course fence or fixed to a moving participant, e.g., a moving golf car or player.", "An object is typically geo-referenced using either a positioning technology, such as GPS, but can also be geo-referenced using machine vision.", "If machine vision is used (i.e.", "object recognition), applications can be “markerless” or use “markers,” sometimes known as “fiducials.” Marker-based augmented reality often uses a square marker with a high contrast.", "In this case, four corner points of a square are detected by machine vision using the square marker and three-dimensional camera information is computed using this information.", "Other detectable sources have also been used, such as embedded LED's or special coatings or QR codes.", "Applying AR to a marker which is easily detected is advantageous in that recognition and tracking are relatively accurate, even if performed in real time.", "So, in applications where precise registration of the AR message in the background environment is important, a marker based system has some advantages.", "In a “markerless” system, AR uses a general natural image instead of a fiducial.", "In general, markerless AR uses a feature point matching method.", "Feature point matching refers to an operation for searching for and connecting the same feature points in two different images.", "One method for feature recognition is discussed herein in connection with Photsyth.", "A method for extracting a plane uses Simultaneous Localization and Map-building (SLAM)/Parallel Tracking And Mapping (PTAM) algorithm for tracking three-dimensional positional information of a camera and three-dimensional positional information of feature points in real time and providing AR using the plane has been suggested.", "However, since the SLAM/PTAM algorithm acquires the image to search for the feature points, computes the three-dimensional position of the camera and the three-dimensional positions of the feature points, and provides AR based on such information, a considerable computation is necessary.", "A hybrid system can also be used where a readily recognized symbol or brand is geo-referenced and machine vision substitutes the AR message.", "In the present application, the term “social network” is used to refer to any process or system that tracks and enables connections between members (including people, businesses, and other entities) or subsets of members.", "The connections and membership may be static or dynamic and the membership can include various subsets within a social network.", "For example, a person's social network might include a subset of members interested in art and the person shares an outing to a sculpture garden only with the art interest subset.", "Further, a social network might be dynamically configured.", "For example, a social network could be formed for “Nasher Sculpture Garden” for September 22 and anyone interested could join the Nasher Sculpture Garden September 22 social network.", "Alternatively, anyone within a certain range of the event might be permitted to join.", "The permutations involving membership in a social network are many and not intended to be limiting.", "A social network that tracks and enables the interactive web by engaging users to participate in, comment on and create content as a means of communicating with their social graph, other users and the public.", "In the context of the present invention, such sharing and social network participation includes participant created content and spectator created content and of course, jointly created content.", "For example, the created content can be interactive to allow spectators to add content to the participant created event.", "The distinction between photo repositories, such as FLIKR and Photobucket and social networks has become blurred, and the two terms are sometimes used interchangeably herein.", "Examples of conventional social networks include Linkedln.com or Facebook.com, Google Plus, Twitter (including Tweetdeck), social browsers such as Rockmelt, and various social utilities to support social interactions including integrations with HTML5 browsers.", "The website located at www.Wikipedia.org/wiki/list_of_social_networking_sites lists several hundred social networks in current use.", "Dating sites, Listservs, and Interest groups can also serve as a social network.", "Interest groups or subsets of a social network are particularly useful for inviting members to attend an event, such as Google+ “circles” or Facebook “groups.” Individuals can build private social networks.", "Conventional social networking websites allow members to communicate more efficiently information that is relevant to their friends or other connections in the social network.", "Social networks typically incorporate a system for maintaining connections among members in the social network and links to content that is likely to be relevant to the members.", "Social networks also collect and maintain information or it may be dynamic, such as tracking a member's actions within the social network.", "The methods and system hereof relate to dynamic events of a member's actions shared within a social network about the members of the social network.", "This information may be static, such as geographic location, employer, job type, age, music preferences, interests, and a variety of other attributes, In the present application, the venue for an event or “experience” can be a real view or depicted as a photo background environment or a virtual environment, or a mixture, sometimes referred to as “mixed reality.” A convenient way of understanding the environment of the present invention is as a layer of artificial reality or “augmented reality” images overlaid the event venue background.", "There are different methods of creating the event venue background as understood by one of ordinary skill in the art.", "For example, an artificial background environment can be created by a number of rendering engines, sometimes known as a “virtual” environment.", "See, e.g., Nokia's (through its Navteq subsidiary) Journey View which blends digital images of a real environment with an artificial 3D rendering.", "A “virtual” environment or 3D model can be at different levels of resolutions, such as that shown in FIGS.", "A-11D.", "A real environment can be the background as seen through glasses of FIG.", "10, but can also be created using a digital image, panorama or 3D model.", "Such a digital image can be stored and retrieved for use, such as a “street view” or photo, video, or panorama, or other type of stored image.", "Alternatively, many mobile devices have a camera for capturing a digital image which can be used as the background environment.", "Such a camera-sourced digital image may come from the user, friends, social network groups, crowd-sourced, or service provided.", "Because the use of a real environment as the background is common, “augmented reality” often refers to a technology of inserting a virtual reality graphic (object) into an actual digital image and generating an image in which a real object and a virtual object are mixed (i.e.", "“mixed reality”).", "Augmented reality is often characterized in that supplementary information using a virtual graphic may be layered or provided onto an image acquired of the real world.", "Multiple layers of real and virtual reality can be mixed.", "In such applications the placement of an object or “registration” with other layers is important.", "That is, the position of objects or layers relative to each other based on a positioning system should be close enough to support the application.", "As used herein, “artificial reality” (“AR”) is sometimes used interchangeably with “virtual,” “mixed,” or “augmented” reality, it being understood that the background environment can be real or virtual.", "The present application uses the terms “platform” and “server” interchangeably and describes various functions associated with such a server, including data and applications residing on the server.", "Such functional descriptions does not imply that all functions could not reside on the same server or multiple servers or remote and distributed servers, or even functions shared between clients and servers as readily understood in the art.", "The present application uses the term “random” when discussing an image to infer that the acquisition of multiple images is not coordinated, i.e.", "target, orientation, time, etc.", "One category of acquired random images is from “crowdsourcing.” III.", "Mobile Device In more detail, FIG.", "4 is a front elevational view of a mobile device 10, such as a smart phone, which is the preferred form factor for the device 10 discussed herein to illustrate certain aspects of the present invention.", "Mobile device 10 can be, for example, a handheld computer, a tablet computer, a personal digital assistant, goggles or glasses, contact lens, a cellular telephone, a wrist-mounted computer, a camera having a GPS and a radio, a GPS with a radio, a network appliance, a camera, a smart phone, an enhanced general packet radio service (EGPRS) mobile phone, a network base station, a media player, a navigation device, an email device, a game console, or other electronic device or a combination of any two or more of these data processing devices or other data processing.", "Mobile device 10 includes a touch-sensitive graphics display 102.The touch-sensitive display 102 can implement liquid crystal display (LCD) technology, light emitting polymer display (LPD) technology, or some other display technology.", "The touch-sensitive display 102 can be sensitive to haptic and/or tactile contact with a user.", "The touch-sensitive graphics display 102 can comprise a multi-touch-sensitive display.", "A multi-touch-sensitive display 102 can, for example, process multiple simultaneous touch points, including processing data related to the pressure, degree and/or position of each touch point.", "Such processing facilitates gestures and interactions with multiple fingers, chording, and other interactions.", "Other touch-sensitive display technologies can also be used, e.g., a display in which contact is made using a stylus or other pointing device.", "An example of a multi-touch-sensitive display technology is described in U.S. Patent Nos.", "6,323,846; 6,570,557; 6,677,932; and U.S.", "Publication No.", "2002/0015024, each of which is incorporated by reference herein in its entirety.", "Touch screen 102 and touch screen controller can, for example, detect contact and movement or break thereof using any of a plurality of touch sensitivity technologies, including but not limited to capacitive, resistive, infrared, and surface acoustic wave technologies, as well as other proximity sensor arrays or other elements for determining one or more points of contact with touch screen 102.Mobile device 10 can display one or more graphical user interfaces on the touch-sensitive display 102 for providing the user access to various system objects and for conveying information to the user.", "The graphical user interface can include one or more display objects 104, 106, 108, 110.Each of the display objects 104, 106, 108, 110 can be a graphic representation of a system object.", "Some examples of system objects include device functions, applications, windows, files, alerts, events, or other identifiable system objects.", "Mobile device 10 can implement multiple device functionalities, such as a telephony device, as indicated by a phone object; an e-mail device, as indicated by the e-mail object; a network data communication device, as indicated by the Web object; a Wi-Fi base station device (not shown); and a media processing device, as indicated by the media player object.", "For convenience, the device objects, e.g., the phone object, the e-mail object, the Web object, and the media player object, can be displayed in menu bar 118.Each of the device functionalities can be accessed from a top-level graphical user interface, such as the graphical user interface illustrated in FIG.", "4.Touching one of the objects e.g.", "104, 106, 108, 110 etc.", "can, for example, invoke the corresponding functionality.", "In the illustrated embodiment, object 106 represents an Artificial Reality application in accordance with the present invention.", "Object 110 enables the functionality of one or more depth cameras.", "Upon invocation of particular device functionality, the graphical user interface of mobile device 10 changes, or is augmented or replaced with another user interface or user interface elements, to facilitate user access to particular functions associated with the corresponding device functionality.", "For example, in response to a user touching the phone object, the graphical user interface of the touch-sensitive display 102 may present display objects related to various phone functions; likewise, touching of the email object may cause the graphical user interface to present display objects related to various e-mail functions; touching the Web object may cause the graphical user interface to present display objects related to various Web-surfing functions; and touching the media player object may cause the graphical user interface to present display objects related to various media processing functions.", "The top-level graphical user interface environment or state of FIG.", "4 can be restored by pressing button 120 located near the bottom of mobile device 10.Each corresponding device functionality may have corresponding “home” display objects displayed on the touch-sensitive display 102, and the graphical user interface environment of FIG.", "4 can be restored by pressing the “home” display object or reset button 120.The top-level graphical user interface is shown in FIG.", "1 and can include additional display objects, such as a short messaging service (SMS) object, a calendar object, a photos object, a camera object 108, a calculator object , a stocks object, a weather object, a maps object, a notes object, a clock object, an address book object, and a settings object, as well as AR object 106 and depth camera object 110.Touching the SMS display object can, for example, invoke an SMS messaging environment and supporting functionality.", "Likewise, each selection of a display object can invoke a corresponding object environment and functionality.", "Mobile device 10 can include one or more input/output (I/O) devices and/or sensor devices.", "For example, speaker 122 and microphone 124 can be included to facilitate voice-enabled functionalities, such as phone and voice mail functions.", "In some implementations, loud speaker 122 can be included to facilitate hands-free voice functionalities, such as speaker phone functions.", "An audio jack can also be included for use of headphones and/or a microphone.", "A proximity sensor (not shown) can be included to facilitate the detection of the user positioning mobile device 10 proximate to the user's ear and, in response, disengage the touch-sensitive display 102 to prevent accidental function invocations.", "In some implementations, the touch-sensitive display 102 can be turned off to conserve additional power when mobile device 10 is proximate to the user's ear.", "Other sensors can also be used.", "For example, an ambient light sensor (not shown) can be utilized to facilitate adjusting the brightness of the touch-sensitive display 102.An accelerometer (FIG.", "6) can be utilized to detect movement of mobile device 10, as indicated by the directional arrow.", "Accordingly, display objects and/or media can be presented according to a detected orientation, e.g., portrait or landscape.", "Mobile device 10 may include circuitry and sensors for supporting a location determining capability, such as that provided by the global positioning system (GPS) or other positioning system (e.g., Cell ID, systems using Wi-Fi access points, television signals, cellular grids, Uniform Resource Locators (URLs)).", "A positioning system (e.g., a GPS receiver, FIG.", "6) can be integrated into the mobile device 10 or provided as a separate device that can be coupled to the mobile device 10 through an interface (e.g., port device 132) to provide access to location-based services.", "Mobile device 10 can also include one or more front camera lens and sensor 140 and depth camera 142.In a preferred implementation, a backside camera lens and sensor 141 is located on the back surface of the mobile device 10 as shown in FIG.", "5.The conventional RGB cameras 140, 141 can capture still images and/or video.", "The camera subsystems and optical sensors 140, 141 may comprise, e.g., a charged coupled device (CCD) or a complementary metal-oxide semiconductor (CMOS) optical sensor, can be utilized to facilitate camera functions, such as recording photographs and video clips.", "Camera controls (zoom, pan, capture and store) can be incorporated into buttons 134-136 (FIG.", "4.)", "In some embodiments, the cameras can be of different types.", "For example, cameras 140, 141 might be a conventional RGB camera, while cameras 142, 143 comprise a range camera, such as a plenoptic camera.", "Similarly, other sensors can be incorporated into device 10.For example, sensors 146, 148 might be other types of range cameras, such as a time of flight camera (TOF) or LIDAR with 146 the illuminator and 148 the imager.", "Alternatively, in several embodiments the sensors are part of a structured light system where sensor 146 is an IR emitter and sensor 148 is an IR receptor that functions as a depth camera, such as Capri 1.25 available from Primesense.", "The preferred mobile device 10 includes a GPS positioning system.", "In this configuration, another positioning system can be provided by a separate device coupled to the mobile device 10, or can be provided internal to the mobile device.", "Such a positioning system can employ positioning technology including a GPS, a cellular grid, URL's, IMEO, pseudolites, repeaters, Wi-Fi or any other technology for determining the geographic location of a device.", "The positioning system can employ a service provided by a positioning service such as, for example, a Wi-Fi RSS system from SkyHook Wireless of Boston, Mass., or Rosum Corporation of Mountain View, Calif.", "In other implementations, the positioning system can be provided by an accelerometer and a compass using dead reckoning techniques starting from a known (e.g.", "determined by GPS) location.", "In such implementations, the user can occasionally reset the positioning system by marking the mobile device's presence at a known location (e.g., a landmark or intersection).", "In still other implementations, the user can enter a set of position coordinates (e.g., latitude, longitude) for the mobile device.", "For example, the position coordinates can be typed into the phone (e.g., using a virtual keyboard) or selected by touching a point on a map.", "Position coordinates can also be acquired from another device (e.g., a car navigation system) by syncing or linking with the other device.", "In other implementations, the positioning system can be provided by using wireless signal strength and one or more locations of known wireless signal sources (Wi-Fi, TV, FM) to provide the current location.", "Wireless signal sources can include access points and/or cellular towers.", "Other techniques to determine a current location of the mobile device 10 can be used and other configurations of the positioning system are possible.", "Mobile device 10 can also include one or more wireless communication subsystems, such as a 802.11b/g/n communication device, and/or a Bluetooth™ communication device, in addition to near field communications.", "Other communication protocols can also be supported, including other 802.x communication protocols (e.g., WiMax, Wi-Fi), code division multiple access (CDMA), global system for mobile communications (GSM), Enhanced Data GSM Environment (EDGE), 3G (e.g., EV-DO, UMTS, HSDPA), etc.", "Additional sensors are incorporated into the device 10, such as accelerometer, digital compass and gyroscope, see FIG.", "6.A preferred device would include a rangefinder as well.", "Further, peripheral sensors, devices and subsystems can be coupled to peripherals interface 132 to facilitate multiple functionalities.", "For example, a motion sensor, a light sensor, and/or a proximity sensor can be coupled to peripherals interface 132 to facilitate the orientation, lighting and proximity functions described with respect to FIGS.", "4 and 6.Other sensors can also be connected to peripherals interface 132, such as a GPS receiver, a temperature sensor, a biometric sensor, RFID, or any Depth camera or other sensing device, to facilitate related functionalities.", "Preferably, the present invention makes use of as many sensors as possible to collect metadata associated with an image.", "The quantity and quality of metadata aids not only yields better results, but reduces image processing time.", "Port device 132, is e.g., a Universal Serial Bus (USB) port, or a docking port, or some other wired port connection.", "Port device 132 can, for example, be utilized to establish a wired connection to other computing devices, such as other communication devices 10, a personal computer, a printer, or other processing devices capable of receiving and/or transmitting data.", "In some implementations, port device 132 allows mobile device 10 to synchronize with a host device using one or more protocols.", "Input/output and operational buttons are shown at 134-136 to control the operation of device 10 in addition to, or in lieu of the touch sensitive screen 102.Mobile device 10 can include a memory interface to one or more data processors, image processors and/or central processing units, and a peripherals interface (FIG.", "6).", "The memory interface, the one or more processors and/or the peripherals interface can be separate components or can be integrated in one or more integrated circuits.", "The various components in mobile device 10 can be coupled by one or more communication buses or signal lines.", "Preferably, the mobile device includes a graphics processing unit (GPU) coupled to the CPU (FIG.", "6).", "While a Nvidia GeForce GPU is preferred, in part because of the availability of CUDA, any GPU compatible with OpenGL is acceptable.", "Tools available from Kronos allow for rapid development of 3D models.", "Of course, a high performance System on a Chip (SOC) is a preferred choice if cost permits, such as an NVIDIA Tegra 4i with 4 CPU cores, 60 GPU cores, and an LTE modem.", "The I/O subsystem can include a touch screen controller and/or other input controller(s).", "The touch-screen controller can be coupled to touch screen 102.The other input controller(s) can be coupled to other input/control devices 132-136, such as one or more buttons, rocker switches, thumb-wheel, infrared port, USB port, and/or a pointer device such as a stylus.", "The one or more buttons (132-136) can include an up/down button for volume control of speaker 122 and/or microphone 124, or to control operation of cameras 140,141.Further, the buttons (132-136) can be used to “capture” and share an image of the event along with the location of the image capture.", "Finally, “softkeys” can be used to control a function—such as controls appearing on display 102 for controlling a particular application (AR application 106 for example).", "In one implementation, a pressing of button 136 for a first duration may disengage a lock of touch screen 102; and a pressing of the button for a second duration that is longer than the first duration may turn the power on or off to mobile device 10.The user may be able to customize a functionality of one or more of the buttons.", "Touch screen 102 can, for example, also be used to implement virtual or soft buttons and/or a keyboard.", "In some implementations, mobile device 10 can present recorded audio and/or video files, such as MP3, AAC, and MPEG files.", "In some implementations, mobile device 10 can include the functionality of an MP3 player, such as an iPod™.", "Mobile device 10 may, therefore, include a 36-pin connector that is compatible with the iPod.", "Other input/output and control devices can also be used.", "The memory interface can be coupled to a memory.", "The memory can include high-speed random access memory and/or non-volatile memory, such as one or more magnetic disk storage devices, one or more optical storage devices, and/or flash memory (e.g., NAND, NOR).", "The memory can store an operating system, such as Darwin, RTXC, LINUX, UNIX, OS X, WINDOWS, or an embedded operating system such as VxWorks.", "The operating system may include instructions for handling basic system services and for performing hardware dependent tasks.", "In some implementations, the operating system handles timekeeping tasks, including maintaining the date and time (e.g., a clock) on the mobile device 10.In some implementations, the operating system can be a kernel (e.g., UNIX kernel).", "The memory may also store communication instructions to facilitate communicating with one or more additional devices, one or more computers and/or one or more servers.", "The memory may include graphical user interface instructions to facilitate graphic user interface processing; sensor processing instructions to facilitate sensor-related processing and functions; phone instructions to facilitate phone-related processes and functions; electronic messaging instructions to facilitate electronic-messaging related processes and functions; web browsing instructions to facilitate web browsing-related processes and functions; media processing instructions to facilitate media processing-related processes and functions; GPS/Navigation instructions to facilitate GPS and navigation-related processes and instructions; camera instructions to facilitate camera-related processes and functions; other software instructions to facilitate other related processes and functions; and/or diagnostic instructions to facilitate diagnostic processes and functions.", "The memory can also store data, including but not limited to coarse information, locations (points of interest), personal profile, documents, images, video files, audio files, and other data.", "The information can be stored and accessed using known methods, such as a structured or relative database.", "Portable device 220 of FIG.", "10 is an alternative embodiment in the configuration of glasses or goggles and includes a GPS and patch antenna 232, microprocessor and GPU 234, camera 222, and radio 236.Controls, such as the directional pad 224, are on the side frames (opposite side not shown).", "In addition to or in lieu of the control pad 224, a microphone and voice commands run by processor 234, or gestural commands can be used.", "Batteries are stored in compartment 242.The displays are transparent LCD's as at 244.Sensors 246, 248 are preferably associated with a depth camera, such as a TOF camera, structured light camera, or LIDAR, as described herein.", "Alternatively both sensors might comprise a plenoptic camera.", "Examples of similar devices are the MyVue headset made by MicroOptical Corp. of Westwood, Mass.", "(see, e.g., U.S. Pat.", "No.", "6,879,443), Vuzix Wrap 920 AR, 1200 VR, Smart Glasses M 100 and Tac-Eye LT available from Vuzix Corporation, Rochester, N.Y. A more immersive experience is available using the Occulus Rift head mounted display (HMD) available from Occulus VR of Southern Calif.", "Such immersive virtual reality HMD's are advantageous in certain applications and the terms “glasses” or “goggles” when used in the present application are meant to include such immersive HMD's.", "A particular benefit of the use of wearable glasses such as the embodiment of FIG.", "10 is the ability to incorporate augmented reality messages and information, e.g.", "point of interest overlays onto the “real” background.", "Of course, augmented reality can also be used with portable device 10 of FIGS.", "4-9 using one or more cameras, 140, 141, 142, 143, 146 or 148.In the golf example, a golfer wearing glasses 220 can see the AR messages and course information and selectively highlight a particular message and additional information relative to that message (e.g.", "layup area, wind used in club selection, next best club selection, status of other golfers rounds, etc.).", "See, e.g.", "U.S. Pat.", "Nos.", "7,002,551; 6,919,867; 7,046,214; 6,945,869; 6,903,752; 6,317,127 (herein incorporated by reference).", "Another benefit of wearable glasses such as the embodiment of FIG.", "10 is the ability to easily control the glasses 220 or any tethered smartphone by use of a gestural interface.", "That is, in addition to or as an alternative to buttons or keys on glasses 220 or the use of voice commands, gestures can be used to control operation of glasses 220.Such gestures can be recognized by any of the cameras or sensors, depending on the application.", "Depth cameras (such as Kinect or Claris) have proven particularly adapted for use in a gestural interface.", "However, conventional cameras such as RGB camera 222 have also been employed for simple gesture recognition.", "(See, Flutter of Mountain View, Calif.).", "See also, U.S.", "Publication Nos.", "2010/0083190; 2002/0118880; 2010/0153457; 2010/0199232; and U.S. Pat.", "No.", "7,095,401.There are several different types of “range” or “depth” cameras that can be used in a mobile device, such as mobile devices 10, 220.Broadly speaking, depth cameras use: Stereo triangulation Sheet of light triangulation Structured light Time-of-flight Interferometry Coded Aperture In the present application, “depth camera” or alternatively “range camera” is sometimes used to refer to any of these types of cameras.", "While certain embodiments of the present invention can use different types of depth cameras, the use of triangulation (stereo), structured light, and time of flight (TOF) cameras are advantageous in certain embodiments discussed herein.", "As shown in FIG.", "15, with a conventional camera, photographers at points A, B, and C are photographing a Target 200.The metadata (EXIF, FIG.", "12) gives orientation and Depth of Field from each point A, B, and C. I.e.", "the orientations and depth of field associated with vectors from the points A, B, and C to the target in FIG.", "1b.", "Depth of field refers to the range of distance that appears acceptably sharp, i.e.", "in focus.", "It varies depending on camera type, aperture and focusing distance, among other things.", "This “sharpness” or “focus” is a range, and often referred to as a circle of confusion.", "An acceptably sharp circle of confusion is loosely defined as one which would go unnoticed when enlarged to a standard 8×10 inch print, and observed from a standard viewing distance of about 1 foot.", "For digital imaging, an image is considered in focus if this blur radius is smaller than the pixel size p. As shown in FIG.", "15, the metadata greatly aids in locating the position of the target 200, and in this example, location data of Points A, B and C are known from GPS data.", "However, the location of the target converges to a smaller “area” as more points and images are taken of the target 200.In FIG.", "15 an image is acquired from Point A along vector 210 to target 200.The area of uncertainty is denoted as arc 216.As can be seen, with images taken from Points B, C along vectors 212, 214, the location of the target converges to a small area denoted at 200.In stereo triangulation, the present application contemplates that different cameras are used from different locations A, B, C as shown in FIG.", "15.Alternatively, a single camera with 2 sensors offset from each other, such as the BumbleBee2 available from Point Grey Research Inc. of Richmond, B.C., Canada can be used to obtain depth information from a point to the target, e.g.", "Point A to target 200.See, U.S. Pat.", "Nos.", "6,915,008; 7,692,684; 7,167,576.Structured Light as a depth imaging technology has gained popularity with the introduction of the Microsoft Kinect game system (see also Asus XtionPro).", "A structured light imaging systems projects a known light pattern into the 3D scene, viewed by camera(s).", "Distortion of the projected light pattern allows computing the 3D structure imaged by the projected light pattern.", "Generally, the imaging system projects a known pattern (Speckles) in Near-Infrared light.", "A CMOS IR camera observes the scene.", "Calibration between the projector and camera has to be known.", "Projection generated by a diffuser and diffractive element of IR light.", "Depth is calculated by triangulation of each speckle between a virtual image (pattern) and observed pattern.", "Of course, a number of varieties of emittors and detectors are equally suitable, such as light patterns emitted by a MEMS laser or infrared light patterns projected by an LCD, LCOS, or DLP projector.", "Primesense manufactures the structured light system for Kinect and explains in greater detail its operation in WO 2007/043036 and U.S. Pat.", "Nos.", "7,433,024; 8,050,461; 8,350,847.See also, U.S.", "Publication Nos.", "2012/0140109; 2012/0042150; 2009/0096783; 2011/0052006, 2011/0211754.See also, U.S.", "Publication Nos.", "2012/0056982; 2008/0079802; 2012/0307075; and U.S. Pat.", "Nos.", "8,279,334; 6,903,745; 8,044,996 (incorporated by reference).", "Scanners using structured light are available from Matterport of Mountain View, Calif.", "The current Kinect system uses an infrared projector, an infrared camera (detector) and an RGB camera.", "The current Kinect system has a Depth resolution of 640×480 pixels, an RGB resolution: 1600×1200 pixels, images at 60 FPS, has an Operation range of 0.8 m˜3.5 m, spatial x/y resolution of 3 mm @2 m distance and depth z resolution of 1 cm @2 m distance.", "The system allows for marker less human tracking, gesture recognition, facial recognition, motion tracking.", "By extracting many interest points at local geodesic extrema with respect to the body centroid during the calibration stage, the system can train a classifier on depth image paths and classify anatomical landmarks (e.g.", "head, hands, feet) of several individuals.", "New Kinect systems can obtain the same resolution at distance approaching 60 meters and accommodate more individuals and a greater number of anatomical landmarks.", "The new Kinect systems reportedly have a field of view of 70 degrees horizontally and 60 degrees vertically a 920×1080 camera changing from 24-bit RGB color to 16-bit YUV.", "The video will stream at 30 fps.", "The depth resolution also improves from a 320×240 to 512×424, and it will employ an IR stream—unlike the current-gen Kinect—so the device can see better in an environment with limited light.", "Further, latency will be reduced by incorporating USB 3.0.Further, Primesense has recently introduced an inexpensive, small version of its sensor system that can be incorporated into mobile devices, the embedded 3D sensor, Capri 1.25.For example, in FIG.", "5, sensors 146, 148 in some applications constitute emitters/receptors for a structured light system.", "A time of flight (TOF) camera is a class of LIDAR and includes at least an illumination unit, lens and an image sensor.", "The illumination unit typically uses an IR emitter and the image sensor measures the time the light travels from the illumination unit to the object and back.", "The lens gathers and projects the reflected light onto the image sensor (as well as filtering out unwanted spectrum or background light.)", "For example, in FIG.", "5, in some embodiments sensor 146 comprises an illumination sensor and senor 148 is the image sensor.", "Alternatively, sensors 146, 148 can operate as a part of a scanned or scannerless LIDAR system using coherent or incoherent light in other spectrums.", "Such TOF cameras are available from PMDVision (Camcube or Camboard), Mesa Imaging, Fotonic (C-40, C-70) or ifm.", "Image processing software is available from Metrilus, GmbH of Erlangen Germany.", "Plenoptic Cameras can be used as any of the sensors 140-148 in FIG.", "5 or 222, 246, 248 in FIG.", "10.Plenoptic Cameras sample the plenoptic function and are also known as Light Field cameras and sometimes associated with computational photography.", "Plenoptic cameras are available from several sources, such as Lytos, Adobe, Raytrix and Pelican Imaging.", "See, e.g., U.S. Pat.", "Nos.", "8,279,325; 8,289,440; 8,305,456; 8,265,478, and U.S.", "Publication Nos.", "2008/0187305; 2012/0012748; 2011/0669189 and www.lytro.com/science_inside (all incorporated by reference).", "Generally speaking, Plenoptic cameras combine a micro-lens array with a square aperture and a traditional image sensor (CCD or CMOS) to capture an image from multiple angles simultaneously.", "The captured image, which looks like hundreds or thousands of versions of the exact same scene, from slightly different angles, is then processed to derive the rays of light in the light field.", "The light field can then be used to regenerate an image with the desired focal point(s), or as a 3D point cloud.", "The software engine is complex, but many cameras include a GPU to handle such complicated digital processing.", "Ideally, a plenoptic camera is about the same cost as a conventional camera, but smaller by eliminating the focus assembly.", "Focus can be determined by digital processing, but so can depth of field.", "If the main image is formed in front of the microlense array, the camera operates in the Keplerian mode; with the image formed behind the microlense array, the camera is operating in the Galilean mode.", "See, T. Georgieu et al, Depth of Field in Plenoptic Cameras, Eurograhics, 2009.With conventional photography, light rays 430 pass through optical elements 432 and are captured by a sensor 434 as shown in FIG.", "16A.", "Basically, a pixel 436 on the sensor 434 is illuminated by all of the light rays 430 and records the sum of the intensity of those rays.", "Information on individual light rays is lost.", "With Light Field photography (also referred to herein as “plenoptic”), information on all of the light rays (radiance) is captured and recorded as shown in FIG.", "16B.", "By capturing radiance, a picture is taken “computationally.” In FIG.", "16B, an object 410 is imaged by a lense system 412.A virtual image 414 appears at the computational plane 416, with the images combined on the main sensor 420.The microlense array 418 has a plurality of sensors that each act as its own small camera that look at the virtual image from a different position.", "In some plenoptic cameras, the array might approach 20,000 microlense and even have microlense with different focal lengths giving a greater depth of field.", "With advances in silicon technology, the arrays can grow quite large—currently 60 MP sensors are available—and Moore's law seems to apply, meaning quite large sensor arrays are achievable to capture richer information about a scene.", "The computational power (e.g.", "GPU) to process these images is growing at the same rate to enable rendering in real time.", "With computational photography, the optical elements are applied to the individual rays computationally and the scene rendered computationally.", "A plenoptic camera is used to capture the scene light ray information.", "Plenoptic cameras are available from Adobe, Lyto, Pelican Imaging of Palo Alto, California.", "In such a plenoptic camera, microlenses are used to create an array of cameras to sample the plenoptic function.", "Typically, the picture would be rendered by using a GPU, such as from NVIDIA (GeForce 580), programmed using CUDA or Open GL Shader Language.", "Expressed another way, a light field camera combines a micro-lens array with a software engine, typically running on a GPU to create a plenoptic camera.", "Essentially, the micro-lens array 418 is used with a square aperture and a traditional image sensor 420 (CCD or CMOS) to capture a view of an object 410 from multiple angles simultaneously.", "The captured image, which looks like hundreds or thousands of versions of the exact same scene, from slightly different angles, is then processed to derive the rays of light in the light field.", "The light field can then be used to regenerate an image with the desired focal point(s), or as a 3D point cloud.", "Therefore, in certain embodiments the use of a plenoptic camera and computational photography is believed preferable.", "To accurately calculate depth information in a scene with conventional cameras, two images must be compared and corresponding points matched.", "Depth is then extracted by triangulation as explained herein.", "By using plenoptic cameras and computational photography, some amount of stereo is built into the camera by using an array of microlenses.", "That is, the depth of field can be computed for different points in a scene.", "IV.", "Network Operating Environment By way of example, in FIG.", "3 the communication network 205 of the system 100 includes one or more networks such as a data network (not shown), a wireless network (not shown), a telephony network (not shown), or any combination thereof.", "It is contemplated that the data network may be any local area network (LAN), metropolitan area network (MAN), wide area network (WAN), a public data network (e.g., the Internet), or any other suitable packet-switched network, such as a commercially owned, proprietary packet-switched network, e.g., a proprietary cable or fiber-optic network.", "In addition, the wireless network may be, for example, a cellular network and may employ various technologies including enhanced data rates for global evolution (EDGE), general packet radio service (GPRS), global system for mobile communications (GSM), Internet protocol multimedia subsystem (IMS), universal mobile telecommunications system (UMTS), etc., as well as any other suitable wireless medium, e.g., worldwide interoperability for microwave access (WiMAX), Long Term Evolution (LTE) networks, code division multiple access (CDMA), wideband code division multiple access (WCDMA), wireless fidelity (WiFi), satellite, mobile ad-hoc network (MANET), and the like.", "By way of example, the mobile devices smart phone 10, tablet 12, glasses 220, and experience content platform 207 communicate with each other and other components of the communication network 205 using well known, new or still developing protocols.", "In this context, a protocol includes a set of rules defining how the network nodes within the communication network 205 interact with each other based on information sent over the communication links.", "The protocols are effective at different layers of operation within each node, from generating and receiving physical signals of various types, to selecting a link for transferring those signals, to the format of information indicated by those signals, to identifying which software application executing on a computer system sends or receives the information.", "The conceptually different layers of protocols for exchanging information over a network are described in the Open Systems Interconnection (OSI) Reference Model.", "In one embodiment, an application residing on the device 10 and an application on the content platform 207 may interact according to a client-server model, so that the application of the device 10 requests experience and/or content data from the content platform 207 on demand.", "According to the client-server model, a client process sends a message including a request to a server process, and the server process responds by providing a service (e.g., providing map information).", "The server process may also return a message with a response to the client process.", "Often the client process and server process execute on different computer devices, called hosts, and communicate via a network using one or more protocols for network communications.", "The term “server” is conventionally used to refer to the process that provides the service, or the host computer on which the process operates.", "Similarly, the term “client” is conventionally used to refer to the process that makes the request, or the host computer on which the process operates.", "As used herein, the terms “client” and “server” refer to the processes, rather than the host computers, unless otherwise clear from the context.", "In addition, the process performed by a server can be broken up to run as multiple processes on multiple hosts (sometimes called tiers) for reasons that include reliability, scalability, and redundancy, among others.", "In one embodiment, the crowdsourced random images and metadata can be used to update the images stored in a database.", "For example, in FIG.", "3 a newly acquired image from a mobile device 10, 220 can be matched to the corresponding image in a database 212.By comparing the time (metadata, e.g.", "FIG.", "12) of the newly acquired image with the last update to the database image, it can be determined whether the database image should be updated.", "That is, as images of the real world change, the images stored in the database are changed.", "For example if the façade of a restaurant has changed, the newly acquired image of the restaurant façade will reflect the change and update the database accordingly.", "In the context of FIG.", "3, the Image database 212 is changed to incorporate the newly acquired image.", "Of course, the databases 212, 214 can be segregated as shown, or contained in a unitary file storage system or other storage methods known in the art.", "In one embodiment, a location module determines the user's location by a triangulation system such as a GPS 250, assisted GPS (A-GPS) A-GPS, Cell of Origin, wireless local area network triangulation, or other location extrapolation technologies.", "Standard GPS and A-GPS systems can use satellites to pinpoint the location (e.g., longitude, latitude, and altitude) of the device 10.A Cell of Origin system can be used to determine the cellular tower that a cellular device 10 is synchronized with.", "This information provides a coarse location of the device 10 because the cellular tower can have a unique cellular identifier (cell-ID) that can be geographically mapped.", "The location module may also utilize multiple technologies to detect the location of the device 10.In a preferred embodiment GPS coordinates are processed using a cell network in an assisted mode (See, e.g., U.S. Pat.", "Nos.", "7,904,096; 7,468,694; U.S.", "Publication No.", "2009/0096667) to provide finer detail as to the location of the device 10.Alternatively, cloud based GPS location methods may prove advantageous in many embodiments by increasing accuracy and reducing power consumption.", "See e.g., U.S.", "Publication Nos.", "2012/0100895; 2012/0151055.The image Processing Server 211 of FIG.", "3 preferably uses the time of the image to post process the AGPS location using network differential techniques.", "As previously noted, the location module may be utilized to determine location coordinates for use by an application on device 10 and/or the content platform 207 or image processing server 211.And as discussed in connection with FIG.", "15, increased accuracy reduces the positioning error of a target, reducing computational effort and time.", "V. Data Acquisition, Conditioning and Use The goal is to acquire as many useful images and data to build and update models of locations.", "The models include both 3D virtual models and images.", "A basic understanding of Photogrammetry is presumed by one of ordinary skill in the art, but FIGS.", "13a and 13b illustrate basic concepts and may be compared with FIG.", "16A.", "As shown in FIG.", "13a, an image sensor is used, such as the CCD or CMOS array of the mobile phone 10 of FIG.", "3.Knowing the characteristics of the lens and focal length of the camera 140, 141 of the device 10 aids resolution.", "The device 10 has a focal length of 3.85 mm and a fixed aperture of 2.97, and an FNumber of 2.8.FIG.", "12 shows a common EXIF format for another camera associated with a Casio QV-4000.When a user of the camera 140, 141 in the device 10 acquires an image, the location of the “point of origin” is indeterminate as shown in FIG.", "13a, but along the vector or ray as shown.", "The orientation of the device 10 allows approximation of the orientation of the vector or ray.", "The orientation of the device 10 or 220 is determined using, for example, the digital compass, gyroscope, and even accelerometer (FIG.", "6).", "A number of location techniques are known.", "See, e.g., U.S.", "Publication Nos.", "2011/0137561; 2011/0141141; and 2010/0208057.", "(Although the '057 publication is more concerned with determining the position and orientation “pose” of a camera based on an image, the reverse use of such techniques is useful herein where the camera position and orientation are known.)", "As shown in FIG.", "13b, the unique 3D location of the target can be determined by taking another image from a different location and finding the point of intersection of the two rays (i.e.", "stereo).", "A preferred embodiment of the present invention makes use of Photogrammetry where users take random images of multiple targets.", "That is, multiple users take multiple images of a target from a number of locations.", "Knowing where a camera was located and its orientation when an image is captured is an important step in determining the location of a target.", "Aligning targets in multiple images allows for target identification as explained herein.", "See, e.g., U.S. Pat.", "No.", "7,499,079.Image alignment and image stitching is well known by those of skill in the art.", "Most techniques use either pixel to pixel similarities or feature based matching.", "See, e.g., U.S. Pat.", "No.", "7,499,079 and U.S.", "Publication No.", "2011/0187746; 2012/478569; 2011/0173565.For example, Microsoft has developed algorithms to blend overlapping images, even in the presence of parallax, lens distortion, scene motion and exposure differences in their “photosynch” environment.", "Additionally, Microsoft has developed and deployed its “Photosynth” engine which analyzes digital photographs and generates a 3D model and a point mesh of a photographed object.", "See, e.g., U.S.", "Publication Nos.", "2010/0257252; 2011/0286660; 2011/0312374; 2011/0119587; 2011/0310125; and 2011/0310125.See also, U.S. Pat.", "Nos.", "7,734,116; 8,046,691; 7,992,104; 7,991,283 and U.S.", "Publication No.", "2009/0021576.The photosynth engine is used in a preferred embodiment of the invention.", "Of course, other embodiments can use other methods known in the art for image alignment and stitching.", "The first step in the Photosynth process is to analyze images taken in the area of interest, such as the region near a point of interest.", "The analysis uses an feature point detection and matching algorithm based on the scale-invariant feature transform (“SIFT”).", "See, the D. Lowe SIFT method described in U.S. Pat.", "No.", "6,711,293.Using SIFT, feature points are extracted from a set of training images and stored.", "A key advantage of such a method of feature point extraction transforms an image into feature vectors invariant to image translation, scaling, and rotation, and partially invariant to illumination changes and local geometric distortion.", "This feature matching can be used to stitch images together to form a panorama or multiple panoramas.", "Variations of SIFT are known to one of ordinary skill in the art: rotation-invariant generalization (RIFT); G-RIFT (Generalized RIFT); Speeded Up Robust Features (“SURF”), PCA- SIFT, and GLOH.", "This feature point detection and matching step using SIFT (or known alternatives) is computationally intensive.", "In broad form, such feature point detection uses the photogrammetry techniques described herein.", "In the present invention, computation is diminished by providing very accurate positions and orientation of the cameras and using the metadata associated with each image to build the 3D point cloud (e.g.", "model).", "The step of using the 3D model begins with downloading the Photosynth viewer from Microsoft to a client computer.", "The basics of such a viewer derives from the DeepZoom technology originated by Seadragon (acquired by Microsoft).", "See, U.S. Pat.", "Nos.", "7,133,054 and 7,254,271 and U.S.", "Publication Nos.", "2007/0104378; 2007/0047102; 2006/0267982; 2008/0050024; and 2007/0047101.Such viewer technology allows a user to view images from any location or orientation selected by a user, zoom in or out or pan an image.", "VI.", "General Overview of Operation and Use FIG.", "1a shows a plaza 300 in a perspective view, while FIG.", "1b is a plan view of plaza 300.As an example, a plurality of images are taken by different users in the plaza 300 at locations A-E at different times, FIG.", "1b.", "The data acquired includes the image data (including depth camera data and audio if available) and the metadata associated with each image.", "While FIG.", "12 illustrates the common EXIF metadata associated with an image, the present invention contemplates additional metadata associated with a device, such as available from multiple sensors, see e.g.", "FIGS.", "5, 6, 10.In a preferred embodiment, as much information as possible is collected in addition to the EXIF data, including the data from the sensors illustrated in FIG.", "6.Preferably, the make and model of the camera in the device 10 is also known, from which the focal length, lens and aperture are known.", "Additionally, in a preferred form the location information is not unassisted GPS, but assisted GPS acquired through the cell network which substantially increases accuracy, both horizontal and vertical.", "By knowing the time the image was taken and approximate location, differential corrections and post processing can also be applied to the approximate location, giving a more precise location of the image.", "See, e.g., U.S. Pat.", "Nos.", "5,323,322; 7,711,480; and 7,982,667.The data thus acquired from users at locations A-E using e.g.", "devices 10, 12, or 220, are collected by the image processing server 211 as shown in FIG.", "3.The data is preferably conditioned by eliminating statistical outliers.", "Using a feature recognition algorithm, a target is identified and location determined using the photogrammetry techniques discussed above.", "As can be appreciated, the more precise the locations where an image is acquired (and orientation) gives a more precise determination of target locations.", "Additionally, a converging algorithm such as least squares is applied to progressively determine more precise locations of targets from multiple random images.", "In the preferred embodiment, the camera model and ground truth registration described in R.I. Harley and A. Zisserman, Multiple View Geometry in Computer Vision, Cambridge University Press, 2000 is used.", "The algorithm for rendering the 3D point cloud in OpenGL described in A. Mastin, J. Kepner, and J. Fisher, “Automatic Registration of LIDAR and Optimal Images of Urban Scenes,” IEEE 2009.See also, L. Liu, I. Stamos, G. Yu, G. Wolberg, and S. Zokai, “Multiview Geometry For Texture Mapping 2d Images onto 3d Rang Data,” CVPR '06, Proceedings of the 2006 IEEE Computer Society Conference, pp.", "2293-2300.In a preferred form, the LIDAR data of an image is registered with the optical image by evaluating the mutual information: e.g.", "mutual elevation information between LIDAR elevation of luminance in the optical image; probability of detection values (pdet) in the LIDAR point cloud and luminance in the optical image; and, the joint entropy among optical luminance, LIDAR elevation and LIDAR pdet values.", "The net result is the creation of a 3D model by texture mapping the registered optical images onto a mesh that is inferred on the LIDAR point cloud.", "As discussed herein, in lieu of, or in addition to LIDAR, other depth cameras may be used in certain embodiments, such as plenoptic cameras, TOF cameras, or structured light sensors to provide useful information.", "For each point in the 3D mesh model, a precise location of the point is known, and images acquired at or near a point are available.", "The number of images available of course depends on the richness of the database, so for popular tourist locations, data availability is not a problem.", "Using image inference/feathering techniques (See U.S. Pat.", "No.", "7,499,079) images can be extrapolated for almost any point based on a rich data set.", "For each point, preferably a panorama of images is stitched together and available for the point.", "Such a panorama constitutes a 3D representation or model of the environment from the chosen static point.", "Different techniques are known for producing maps and 3D models, such as a point mesh model.", "See e.g.", "U.S. Pat.", "No.", "8,031,933; U.S.", "Publication Nos.", "2008/0147730; and 2011/0199479.Further, the images may be acquired and stitched together to create a 3D model for an area by traversing the area and scanning the area to capture shapes and colors reflecting the scanned objects in the area visual appearance.", "Such scanning systems are available from Matterport of Mountain View, Calif., which include both conventional images and structured light data acquired in a 360′ area around the scanner.", "A 3D model of an area can be created by scanning an area from a number of points creating a series of panoramas.", "Each panorama is a 3D model consisting of images stitched to form a mosaic, along with the 3D depth information (from the depth camera) and associated metadata.", "In other words, traversing an area near a point of interest and scanning and collecting images over multiple points creates a high fidelity 3D model of the area near the point of interest.", "Georeferenced 3D models are known, with the most common being Digital Surface Models where the model represents the earth's terrain with at least some of the surface objects on it (e.g.", "buildings, streets, etc.).", "Those in the art sometimes refer to Digital Elevation Models (DEM's), with subsets of Digital Surface Models and Digital Terrain Models.", "FIG.", "11 shows the earth's surface with objects displayed at various levels of detail, and illustrates a possible georeference of plaza 300 in an urban environment.", "LIDAR is often used to capture the objects in georeference to the earth's surface.", "See, BLOM3D at http://www.blomasa.com.", "FIG.", "11a is a wire frame block model in an urban environment where the 3D buildings are represented as parallelogram blocks, with no information on roofs or additional structures.", "This is the simplest data model.", "FIG.", "11b is a RoofTop Model that adds roof structure and other constructions present on the buildings.", "This is a much more detailed and precise model and may include color.", "FIG.", "11c is a Library Texture Model adds library textures have been to the Rooftop model of FIG.", "11b.", "The result is a closer approximation of reality, with a smaller volume of data than a photo-realistic model, which makes it ideal for on-board or navigation applications in which the volume of data is a limitation.", "FIG.", "11d is a Photo-realistic Texture Model that adds building textures to the Rooftop model of FIG.", "11b.", "The textures are extracted from the imagery, metadata and LIDAR information.", "On top of any of the 3D models of FIG.", "11 can be layered additional information in even greater detail.", "The greater the detail (i.e.", "higher fidelity), the closer the model approximates photorealistic.", "That is, the 3D virtual model becomes realistic to an observer.", "The tradeoff, of course, is having to handle and manipulate large data sets.", "Each model has its application in the context of the system and methods of the present invention.", "Any reference to a “3D model” when used in the present application should not imply any restrictions on the level of detail of the model.", "FIG.", "14 is a schematic to illustrate the process of image alignment and stitching, where mosaic 400 is the result of using images 402, 404, and 406.Comparing FIG.", "11b and FIG.", "14, the assumption is that images 402, 404, 406 correspond to images taken from locations A, B and D respectively.", "The line of sight (i.e.", "the vector or ray orientation from a camera position) for each image 402, 404, 406 is used and described in a coordinate system, such as a Cartesian or Euler coordinate system.", "The region of overlap of the images defines a volume at their intersection, which depends on the accuracy of the locations and orientations of the cameras (i.e.", "pose) and the geometry of the images.", "However, the search space for feature recognition is within the volume, e.g.", "for applying the photosynth technique described herein.", "The contributions from each image 402, 404, 406 are used to form the mosaic 400.Such mosaic construction techniques are known, such as U.S. Pat.", "No.", "7,499,079.The boundaries are “feathered” to eliminate blurring and to provide a smooth transition among pixels.", "Multiple mosaics can be constructed and aligned to form a panorama.", "Once a 3D model has been created, there exists a variety of methods for sharing and experiencing the environment created.", "FIG.", "17 illustrates one form of an experience viewing system, namely a room 500 accommodating one or more users 510, which allows an experience to be wholly or partially projected within the room.", "See, U.S.", "Publication No.", "2012/0223885.In the embodiment shown in FIG.", "17, a projection display device 502 is configured to project images 504 in the room 500.Preferably the projection display device 502 includes one or more projectors, such as a wide-angle RGB projector, to project images 504 on the walls of the room.", "In FIG.", "17, the display device 502 projects secondary information (images 504) and primary display 506, such as an LCD display, displays the primary information.", "However, it should be understood that either display 502 or 506 can operate without the other device and display all images.", "Further, the positioning of the devices 502, 506 can vary; e.g.", "the projection device 502 can be positioned adjoining primary display 506.While the example primary display 104 and projection display device 502 shown in FIG.", "17 include 2-D display devices, suitable 3-D displays may be used.", "In other embodiments, users 102 may experience 3D environment created using glasses 220 (FIG.", "10).", "In some forms the glasses 220 might comprise active shutter glasses configured to operate in synchronization with suitable alternate-frame image sequencing at primary display 506 and projection display 502.Optionally, the room 500 may be equipped with one or more camera systems 508 which may include one or more depth camera and conventional cameras.", "In FIG.", "17, depth camera 508 creates three-dimensional depth information for the room 500.As discussed above, in some embodiments, depth camera 500 may be configured as a time-of-flight camera configured to determine spatial distance information by calculating the difference between launch and capture times for emitted and reflected light pulses.", "Alternatively, in some embodiments, depth camera 508 may include a three-dimensional scanner configured to collect reflected structured light, such as light patterns emitted by a MEMS laser or infrared light patterns projected by an LCD, LCOS, or DLP projector.", "It will be understood that, in some embodiments, the light pulses or structured light may be emitted by any suitable light source in camera system 508.It should be readily apparent that use of depth cameras, such as Kinect systems, in camera system 508 allows for gestural input to the system.", "In addition, the use in camera system 508 of conventional cameras and depth camera allows for the real time capture of activity in the room 500, i.e.", "the creation of a 3D model of the activity of the users 510 in the room 500.FIG.", "18 shows another room in the configuration of a wedding chapel 600.In the embodiment of FIG.", "18, emphasis is on the capture of images and the building of a 3D model of the events occurring within the wedding chapel 600.In the wedding chapel 600 the use of camera systems 602 allows for the real-time capture of activity in the wedding chapel 600, i.e.", "the creation of a 3D model of the activity of the users in the wedding chapel 600.The camera systems 602 include a plurality of depth cameras and conventional cameras, and also microphones to capture the audio associated with the wedding.", "Additional microphones (not shown) can be positioned based on acoustics of the room and the event to more fully capture the audio associated with the wedding.", "In a preferred form, the wedding chapel 600 has been scanned in advance of any event with a composite scanning system having both depth cameras and conventional cameras.", "Scans are taken at a large number of locations within the chapel 600 to increase the fidelity of the 3D model created for the chapel 600.The acquired scans are processed, i.e.", "by the image processing server 211 of FIG.", "3 and stored in a database for later access by the experience platform 207.During the event, i.e.", "the wedding, the camera systems 602 additionally capture images (and audio) of the event.", "Further, one or more wedding guests are accompanied with a mobile device 10, 12, or 220, to capture images and audio from the event and wirelessly convey the information to the network 205 (FIG.", "3).", "The information captured in real-time during the event are processed at server 211 (FIG.", "3) and update the databases 212, 214.The experience platform 207 is therefore accessible to observers remote from the wedding chapel 600.It will be appreciated that such remote users can experience the event (wedding) by a variety of methods, either historically or in real-time.", "As can be appreciated from FIG.", "3 the remote observers can use mobile devices 10, 12 or 220 to observe the event.", "Additionally the remote observers can be present in room 500 of FIG.", "17 to observe the event.", "VII.", "Examples of Use A few examples are useful for illustrating the operation of the system and methods hereof in a variety of contexts.", "It should be understood that the random images and associated metadata vary by time and space even if taken in the same general area of interest.", "For example, the plaza 300 may be a point of interest, but the details of the 3D model of the plaza may be unknown or outdated.", "Further, while the methods and systems hereof are useful outdoors where GPS is readily available, similar methods and systems can be applied indoors where location determination is more challenging, but indoor positioning systems and depth cameras can substitute for or augment GPS information.", "Further, in addition to collecting data associated with a general region of a point of interest, data can be segregated by time of acquisition, allowing for event recreation and participation.", "1.Crowdsourcing Images: Live News Event A simple example is illustrated in FIG.", "7.In FIG.", "7, protesters 312, 314 are imaged at the plaza 300 at a particular time (plaza 300 is also illustrated in FIGS.", "1a and 1b) by observers with mobile devices, 10, 12, 220.Using multiple random images (random users and/or random locations and/or random orientations at random targets at random times) the protest demonstration (i.e.", "an event) can be captured and wirelessly sent to image processing server 211 via network 205 of FIG.", "3.The images are processed to create or enhance a 3D model of the event (here, a protest) and stored in a database for access.", "The 3D model can be used by a news organization as a replay over a period of time of the demonstration.", "Further, a remote user can view the demonstration from any location in or near the plaza 300 upon request to the content experience platform 207.In a simple case, still pictures and video can be assembled over the time of the protest and accessed from the experience platform 207.For example, the observers recording the protest include depth camera information, the experience platform can also include a 3D model of the plaza 300 and protesters 312, 314.This allows a remote user to select a particular viewing location in the plaza 300 from which to view the protest.", "Where a large number of in-person observers have captured images, the 3D model can achieve a high degree of fidelity.", "Consider a more complex example of an earthquake at sea resulting in a tsunami wave that hits a major coastal city.", "As the wall of water wave comes ashore its sets off a chain reaction of devastating flooding across the entire city.", "A cable news network issues an alert to its impacted viewers to upload captured images from smart phone/devices 10, 12 or goggles 220 to a dedicated, cloud-based server 211 using a downloaded camera phone app 108, 112 (FIG.", "4).", "Additionally high fidelity images from pre-positioned cameras, including depth cameras, throughout the city as well as aerial images are also uploaded to the server 211.Over 10,000 impacted citizens armed with camera equipped smart phones 10 and goggles 220 from all over the city capture images (both photos and video with sound, depth information and associated metadata) of the devastation and upload them to a cloud-based server 211 (either directly or indirectly through image providers and social media).", "The scope of uploaded content includes both exterior images and interior images within city structures (e.g.", "buildings).", "The uploaded content can also include associated location and time specific social media content such as Twitter postings.", "The news organization uses the crowd-sourced content of the event to display in near real-time a panoramic/3D rendering of the tsunami's impact along with a time lapsed rendering of the impact at a point of interest (e.g.", "a beach).", "The images, sounds and 3D model are available to subscribers/users from the experience platform 207 by using the application 106.The application 106 allows many parts of the entire (image available) city to be observed and navigated from virtually any location and point of view that the individual user desires.", "Not only can the user navigate the 3D model of the city, but also the user can access panorama images from many user selected locations within the model.", "Additionally, home users can access the 3D model using intelligent TV, but also may use the mobile devices 10, 12, 220 as a “second screen” component to augment their television or monitor feed.", "Additionally, the user can also view augmented reality enhancements relevant to the particular location they are viewing using a mobile device, such as mobile device 10, 12 or 220.For example: current water depth of flooding, high water level and the status of power availability to that area.", "This crowd-sourced virtual rendering of the devastation is an essential tool for both reporting the news but also managing the response effects.", "It also provides a living history that can be re-experienced (i.e., Walked) at a later date using an enabled mobile network display devices, smart phone 10, 12 or goggles 220 for example.", "Because the live rendering of the environment has real economic value to both the news organization (audience size/advertising revenue) and the response organizations (efficient deployment of resources, protection of life & property), those that contribute to the image bank are sometimes compensated for their sharing of their content.", "The experience metrics of those accessing the 3D environment of the city devastation (time spent, views, actions takes, sharing, related commerce, etc.)", "are tracked by the app and used for analytics to inform experience optimization and related commercial activity.", "2.Rendered Environment For Applying Augmented Reality Enhancements: Retail Environment—Grocery Store Every morning at the Acme Grocery Store, Bob the sales manager and members of his team walk the entire store while filming the available product using their smart phones 10 and/or googles 220.There are additional fixed cameras (such as camera systems 602, FIG.", "18) throughout the store that capture and upload images every minute.", "The mobile devices either recognize the products directly using image recognition, or using QR codes or bar codes appearing near the available products.", "Bob and team upload the images to a processing server 211 that processes/stitches the images into an updated 3D gestalt rendering of the store that can be viewed on any internet/GPS enabled device.", "In this example, uploading the images forces updates to popular 3rd party mapping services such as Google Maps or Bing maps, forcing the images to be current.", "The images also update inventory and location of the products within the store.", "As customers come onto the store (or remotely if they prefer) they can walk the aisles and view freshly updated augmented reality messages about each product and associated promotional messages (pricing, specials, recipes, and/or nutritional info).", "The activity data (movement, time spent, AR interactions, purchases, etc.)", "of shoppers in the store (both in-store and/or remote) is captured and uploaded to the server for consolidation and analytics purposes.", "Shoppers who experience the rendering of the store may not be dependent on using their phone's camera viewfinder.", "Rather, locations in the store are determined using indoor positioning technologies (discussed herein) and updated with current images of the selections.", "Rather than have to annoyingly point their phone's camera at their targets to view these augmented reality messages, multiple points of view and “levels of detail” of the 3D store environment can be displayed and navigated on the customers smart phone 10 (or tablet 12 or glasses 220) without depending on the phone's camera line of sight.", "Users are not required to hold their camera phone 10 in front of their face to enjoy the experience enhancements of augmented reality.", "3.Mirror/Duplicate A Live Event Into Another Location: Super Bowl This year's Super Bowl is being played in the Rose Bowl in Pasadena, Calif. before a sellout crowd of 75,000 fans.", "The Rose Bowl has been mapped in advance, e.g.", "a Google Street View, where imagery, metadata and depth camera information is acquired and stored.", "That is, a high-fidelity 3D model of the Rose Bowl is created in advance, processed, and stored in databases 212, 214 for access via experience platform 207.The high fidelity images of the stadium, field and the participants have been uploaded to the image database 212.The stadium had been retro-fitted with 5,000 wireless cameras (such as e.g.", "the camera systems 602 of FIG.", "18) programmed to capture an image every 2 seconds and automatically upload these images to an image repository 216 and forwarded to a central processing server 211.Similarly, every player's helmet is also fitted with a lightweight, wearable camera, combining a conventional camera with a depth camera and with a microphone that also captures an image every second.", "Referees have similar cameras mounted on the hats.", "Each player and coach has also been fitted with an image tag or marker to aid in augmented reality messaging.", "Plenoptic cameras are advantageous in some respects because of their size (no lens), weight, and power requirements.", "Finally, many fans attending the game are given or already possess a wearable camera, e.g.", "goggles 220 (FIG.", "10) that automatically captures and uploads an image from their viewpoint periodically, e.g.", "every 5 seconds.", "Any or all of the imaging and audio sensors on goggles 220 can be used.", "The images are continuously wirelessly uploaded and processed by the network of FIG.", "3.The high speed processing of all these crowd-sourced images and audio is then used to create a near live, virtual 3D model replicating the game that can be experienced in a number of new ways: Projected as a mirror, live or near live 3D image and synthesized audio into another stadium/venue for viewing by another group(s) of spectators.", "With augmented reality experience enhancements Projected as a miniaturized mirror, live or near live 3D image and synthesized audio into a home viewing “table” or conference room space.", "With augmented reality experience enhancements On any network connected mobile device (smart phone 10, tablet 12, goggles 220 or tv) a new 3D viewing experience is enabled that allows a viewer to consume the experience from almost any perspective of their choosing in the space (any seat, any players point of view to any target or orientation, from above).", "With augmented reality experience enhancements Social media experience enhancements “50 Yard Line Seats” is a concept whereby friends who live in different locations could virtually all sit together at a 3D virtual live rendering of the game on their internet enabled TV, computer, or tablet computer.", "This experience would include the group video conferencing features now found in Google+'s “Huddle” so that friends could interact with each other as they all watched the game from the same perspective.", "For example, the friends can access social network 218 of FIG.", "3 to interact with friends in a virtual environment.", "In one embodiment, the game viewing experience would be made more immersive by extending the crowd-sourced image and audio environment of the game beyond the television and onto the surrounding walls and surfaces of a viewing room 500 as shown in FIG.", "17.Using an the room 500 creates an immersive environment approaching the sights and sounds of attending the game in person, creating the ultimate “man cave” for “attending” events.", "The server could also share metadata of the weather temperature in the stadium with networked appliances (ie.", "HVAC) in the remote viewing structure to automatically align the temperature with that of the event.", "4.Living Maps: Appalachian Trial Bob is planning a hiking trip of the Appalachian Trail, FIG.", "8.Using an application that accesses crowd-sourced images and models from platform 207 from hikers who have previous been on the trail, a 3D model of most of the trail is available for Bob to view in advance on his network enabled device.", "Further, pre-existing images and 3D models such as panoramas are also available for many locations.", "He can view the 3D rendered trail environment from a number of different perspectives, locations and time periods (Fall, Winter, Spring, Summer).", "The rendering can also be enhanced with augmented reality type messaging about the trail including tips and messages from previous trail hikers, sometimes called “graffiti.” In this example, Bob filters the images used to create the environment to be only from the last five years and limits “graffiti” to members of his hiking club that are in his social network.", "Bob uses the application to chart his desired course.", "Bob will be hiking the trail alone but wants to have his father John to “virtually” join him on the journey.", "Bob uses a social media server to invite his father and other friends to virtually join him.", "John accepts Bob invitation to join him which generates a notification to Bob and an event in both their calendars.", "On the day of the hike Bob has with him a GPS enabled smart phone 10 or goggles 220.He launches the Appalachian Trail app, such as apps 108, 110 of FIG.", "4.The launch of the apps 108, 110 sends an alert to John that Bob's hike has started that John (and all the other friends that accepted Bob's invitation) can virtually join him.", "John can access the application to join Bob's hike using his iPad 12, or goggles 220 which sends an alert to Bob's phone 10.On John's display he is able to view several photo-realistic 3D rendering options of the environment that Bob is in as he moves along the trail, e.g.", "FIG.", "8.For example, John has the ability to follow behind Bob, view from above in plan view John as a dot on a map, run up ahead on the trail or look behind.", "If fact all the activity data of virtual viewers is captured and uploaded to the server to provide analytics for optimizing the design, usage and monetization of the 3D trail environment.", "Bob is able to view the same 3D trail rendering on his smart phone 10 or goggles 220 as his father John is viewing remotely.", "The virtual environment includes a number of “augmented reality” experience enhancements including: trail path tip/messages from other hikers (both text and audio) links to historical information historical images of the trial social media messages from those following his progress time, speed and distance performance measurements location and profile of others on the trial Bob is able to view this information/rendering on his phone screen and is not required to use his phone's camera lens to access AR information or trail renderings.", "As Bob walks the trail he is able to have an on-going dialog with his Father John and any of the other friends who have chosen to follow Bob using a social media conferencing capability similar to Google+ Huddle.", "Remote viewers with properly equipped viewing rooms could make their trail viewing experience more immersive by extending the crowd-sourced image environment of the trail beyond the screen of an internet-enabled television or device and onto the surrounding walls and surfaces of the viewing room using an environmental display.", "As Bob enters areas of the trail that are not robust in their image library he get an alert on his phone from the App requesting that he capture images on his phone 10 or goggles 220 and upload them to the processing server 211.Each image will contain information critical to creating the 3D environment (time/date, GPS location, orientation, camera lens information, pixel setting, etc.).", "These alerts help keep the trail images library robust and current on experience platform 207.5.Girls Night Out: Remote Sharing in a 4D Social Experience (4th is Time) Jane is getting married next month but not before several of her best girl friends take her out for a proper bachelorette party at their favorite watering hole, The X Bar, as depicted in FIG.", "9.Jane has been posting about the upcoming party on her Facebook page and several of her out of town friends have asked to be able to remotely share in the experience.", "Jane goes online and creates a Watch Me event on a social network and posts the link to her Facebook page.", "She identifies The X Bar as the location of the event.", "Like a lot of other popular venues, The X Bar has been retrofitted with audio microphones, conventional cameras, and wireless depth cameras, such as one or more camera systems 150 having a conventional camera, structured light camera (Kinect or Claris) and microphone to constantly capture audio, images and movement activity throughout the inside of the facility.", "Additionally, the X Bar has been scanned in advance and an existing 3D model is stored in a database (e.g.", "FIG.", "3).", "The camera systems uploads images and audio in real-time to a cloud server such as server 211.The X Bar makes these images, audio and movement activity available to applications like Watch Me to help create content that drives social buzz around their facility.", "That is, a remote user can access the images and 3D model in real-time via experience platform 207.Historical images inside the X Bar have been uploaded previously so the X Bar environment is known and available in fine detail from platform 207.Real time images and audio from mobile devices 10, 220 accompanying the girl friends in attendance are also uploaded to server 211 and available for Jane's event.", "The X Bar is also equipped with projection capabilities, such as the projector 502 in FIG.", "17, that allow a limited number of remote participants to be visibly present at select tables or regions of the room.", "Several of Jane's girlfriends opt-in on social media to remotely share in the bachelorette party experience.", "Betty, one of Jane's remote friends, elects to be visibly present/projected at the event.", "Betty is in at a remote location that is optimized for immersive participation of remote experience, such as the room 500 of FIG.", "17.By extending the crowd-sourced images and audio, the images and audio from camera systems 150, layered on an existing 3D model creates an environment of the X Bar.", "Use of the system of FIG.", "17 by Betty extends the event experience beyond the screen of an internet-enabled television or mobile device and onto the surrounding walls and surfaces of the viewing room 500 using one or more displays.", "Conversely, Betty's image and movements are also captured by the camera system 508 of FIG.", "17.Betty's image and movements (ex.", "Hologram) are projected into X Bar using projector 502 of FIG.", "9 into a pre-defined location (example wall or table seat) so her virtual presence can also be enjoyed by those physically at Jane's event.", "Betty can also choose to have her projected presence augmented with virtual goods (such as jewelry and fashion accessories) and effects (such as a tan, appearance of weight loss and teeth whitening).", "On the night of the bachelorette party, Jane and each of the physically present girls all use their camera equipped, smart phones 10 or goggles 220 to log into the Watch Me application, such as app 108, 110.Throughout the night from 8 pm till 11 pm they use their smart phones 10 or goggles 220 to capture images and audio of the party's festivities and wirelessly convey them to the network of FIG.", "3.The server 211 aggregates & combines all the images/video and audio captured that evening by all the linked image and audio sources; each of the girls smart phone or goggles cameras along with images provided by The X Bar's real time image feed.", "This data is layered on top of the already existing refined 3D model and images of the X Bar available on the experience platform 207.Each of these crowd-sourced images has detailed metadata (time, GPS location, camera angle, lens, pixel, etc.)", "that is used by the application to stitch together a 4D gestalt of the party experience.", "That can be enhanced with additional layers of augmented reality messaging or imagery and/or audio.", "In addition, at least some of the mobile devices include depth cameras permitting enhanced modeling of the event.", "The aggregation can be a series of photos that can be viewable from a particular location or even a user's chosen location (e.g., Jane's perspective) or preferably a 3D panorama form the user selected location.", "Sue is another one of Jane's friends that opted to view the event remotely.", "Every 15 minutes she gets an alert generated by the Watch Me app that another aggregation sequence is ready for viewing.", "On her iPad 12, Sue opts to view the sequence from Jane's location and an exemplary orientation from the selected point of view.", "Sue can also choose to change the point of view to an “above view” (plan view) or a view from a selected location to Jane's location.", "After viewing the sequence, Sue texts Jane a “wish I was there” message.", "She also uses the Watch Me application to send a round of drinks to the table.", "The day after the party Jane uses the Watch Me app to post a link to the entire 4D photorealistic environment of the entire bachelorette party evening to her Facebook page for sharing with her entire network.", "Members of the network can view the event (and hear the audio) from a selected location within the X Bar.", "6.Mobile Social Gaming Bob and three of his friends are visiting Washington D.C. and are interested in playing a new city-specific mobile “social” multiplayer game called “DC-Spy City.” The game is played using internet enabled mobile phones 10, tablets 2 or googles 220 and the objective is to find and capture other players and treasure (both physical and virtual) over the actual landscape of the city.", "Using crowd-sourced images of Washington D.C. and the real time GPS location of each player, a real-time 3D photo-realistic game environment is rendered for each player.", "Game players and local and remote game observers can individually select from various points of view for observing (above, directly behind, etc) any of the game participants using an internet connected device.", "These environments can also be augmented with additional messaging to facilitate game play information and interaction.", "7.Virtual Trade Show Bill wants to attend CES the electronics industry's major trade show but his company's budget can't afford it.", "The CES event organizers estimate that an additional 2,000 people are like Bill and would be interested in attending the event virtually.", "To facilitate that, fixed cameras have been strategically placed through the event hall and in each of the exhibitor booths and presentation rooms.", "Images and audio are captured using camera systems, such as systems 602 of FIG.", "18, and used to create a live, 3D, photo-realistic environment from which remote attendees can virtually walk and participate in the trade show.", "The event has also created a companion augmented reality application that helps integrate these virtual attendees into the trade show, allowing them to engage with actual event participants, presenters, objects in the booth and exhibitors.", "Additionally, each exhibitor has equipped their booth representatives with internet-based video conferencing mobile devices (ie.", "Goggles 220) so that they can directly interact and share files & documents with the virtual attendees that navigate to their booth.", "Remote participant activity data (path traveled, booths visited, time spent, files downloaded, orders place) within the virtual trade show from the virtual trade show environment is captured and shared with the server.", "Bill can interact with the event remotely by positioning himself in a room, such as room 500 of FIG.", "17.However, Bill elects to participate with his desktop computer by accessing the experience platform 207 of FIG.", "3.From his desktop, Bill can virtually walk through the 3D model of the convention hall and interact with people and objects using artificial reality.", "8.Wedding Venue Distance and the cost of travel are often barriers to friends and family attending a wedding.", "To address that issue the Wedding Chapel 600 of FIG.", "18 has installed a number of fixed camera systems 602 that include depth cameras, such as Kinect, along with high fidelity sound images from light field cameras (plenoptic) throughout the venue so that its optimized for live/near remote, three-dimensional viewing and experience capture.", "Will and Kate are being married overseas in London and many of their close friends cannot attend the wedding but want to actively participate in the experience remotely.", "Prior to the event, each of the remote viewers registers their attendance at the Wedding Chapel website and downloads an application to their internet enabled display device to manage their consumption and participation of the wedding event.", "The application is also integrated with invitation/rsvp attendee information so a complete record of both physical and virtual attendees is available along with their profile information (ex.", "relation to couple, gift, well wishes).", "Will has asked his brother Harry to be his best man.", "Because Harry is currently stationed overseas on active military duty he will serve as Best Man remotely and projected into the experience.", "During the ceremony Will is at a remote location that is optimized for immersive participation in remote experience by extending the crowd-sourced image, audio and movement environment of the Wedding Chapel beyond the screen of an internet-enabled television or display device and onto the surrounding walls and surfaces of the viewing room using an environmental display, such as the room 500 of FIG.", "17.That is, during the ceremony Will can view the event via projectors 502, 506 while camera system 508 captures Will's movements, images, and audio for transmission to the network system 100.That is, Will's image and movements are captured and projected (ex.", "Hologram) into a pre-defined location (ex.", "near the altar) within the Wedding Chapel 600 of FIG.", "18 so his virtual presence can also be viewed by those physically (as well as remotely) at the wedding.", "On the day of the wedding, the application notifies the remote attendees when the event is ready for viewing.", "Each remote viewer has the ability to watch the wedding from any number of perspective views/locations from within and outside of the wedding chapel.", "These views can be stationary (third row/2nd seat or over the ministers shoulder) or moving (perspective from behind the bride as she walks down the aisle) or even from the bride or groom's location.", "After the ceremony the happy couple has access to a 4D gestalt (4=time) of their wedding experience that they can “re-experience” from any number of perspectives from within and outside the Wedding Chapel whenever they like, even sharing with members of their social network.", "VIII.", "Additional Embodiments of Glasses with Gesture Interface FIG.", "10 illustrates a depth sensor in conjunction with a head mounted device 220, which is particularly useful for gestural interface to glasses with cameras and/or tethered smart phones, such as the device 10 of FIG.", "4.Those skilled in the art will appreciate that other configurations and operations are beneficial in many applications where gestural commands are desired.", "Such depth sensors configured for gestural commands can be incorporated into any of the glasses, goggles or HMD's discussed herein or known to those of skill in the art.", "Glasses have existed that incorporate 2D sensors that permit gesture commands.", "Such sensors detect objects in an XY plane and have proven useful for sensing some gestures and objects.", "However, using depth cameras as disclosed herein provides XYZ sensing, opening up a plethora of potential applications to not only more accurately sense a gestural command, but to additionally recognize an object, such as the configuration of a hand making a sign.", "Therefore, a “gestural command” can, for example, include detection of hand motion, configuration, or both.", "FIG.", "19 illustrates another embodiment of glasses 700 incorporating depth cameras that are particularly useful for recognizing gestural commands.", "In FIG.", "19, front facing depth sensors 704, 706, 708 are disposed near the lenses 720 overlaying the user's eyes.", "A conventional RGB camera 702 is illustrated between the lenses 720.Optionally, displays can be substituted for the lenses 720 as in FIG.", "10 for artificial reality applications.", "Side facing depth sensors 710, 712, and 714 are spaced along the port temple of the glasses 700 and optionally, such depth sensors can be incorporated along the starboard temple.", "In one preferred embodiment, the depth sensors 704, 706 represent a pair of conventional RGB optical cameras to obtain a left and right stereo image to provide a depth through stereo triangulation.", "In another preferred embodiment, the depth sensors 704, 706 are light sources (e.g.", "infrared projectors) for illuminating a pattern of structured light.", "Sensor receiver 708 (e.g.", "CMOS IR camera) measures pattern displacement and hence depth is determined and the xyz coordinates of an object near the sensors 704, 706, 708 derived.", "Alternatively, sensors can be mixed.", "For example, a single sensor 704 might comprise an infrared projector and sensor 706 an infrared camera receiver.", "Sensor 708 may then comprise a TOF or other type of depth sensor.", "Similarly, depth sensors 710, 712, and 714 can be configured as a pair of infrared projectors (710, 714) and an infrared receiver, sensor 712.Alternatively, sensor 712 may comprise a time of flight sensor that, as explained herein, transmits light to an object and then acts as a receiver to determine distance to the object.", "The transmitter and receiver can be a single unit as in sensor 712 or discrete units spaced apart.", "The choice of which type of depth sensor to use depends on the application.", "Each technology has different costs, computational (software) complexity, response, accuracy, range and ability to operate in sunlight.", "In some applications, using front facing depth sensors are advantageous, such as when the user's head is covered with a helmet or the user wants to see its gestures in the user's field of view.", "In other applications, using side of the head gestures (e.g.", "swipes) is advantageous, such as in active sports activities.", "In most cases, the depth sensors are used to control a device connected to the glasses 700.The device can be embedded in the glasses, such as RGB camera 702, or otherwise connected through a wire or wirelessly as explained herein.", "As way of example, the front facing depth sensors 704, 706, 708 might control operation of embedded RGB camera 702.Port facing sensors 710, 712, 714 could control tethered smartphone 10 (FIG.", "4).", "Starboard facing sensors (not shown in FIG.", "19) might control a remote 360′ camera or another wirelessly connected device.", "The permutations are varied.", "FIGS.", "20 and 21 illustrate another embodiment of glasses 730 incorporating depth sensors.", "In FIGS.", "20 and 21, starboard depth sensors 740, 742 are shown along with front facing depth sensors 744, 746.In a preferred embodiment, camera 748 is a conventional RGB camera.", "As in connection with FIG.", "19, the choice of depth sensor technology for 740, 742, 744, 746, 748 depends on the application and can be varied.", "For illustrative purposes, FIGS.", "20, 21 illustrate a Field of View (FOV) for a number of sensors for a given distance from the sensor.", "That is, sensor 744 has a FOV 750, while sensor 746 has a FOV 752.FIG.", "22 and FIG.", "23 illustrate the interaction between a Field of View and distance from the sensor.", "For example, in FIG.", "22 the FOV 750 may be accurate and detectable at several distances from sensor 744.For illustration, if the sensor 744 was a particular sensor based on structured light, the detectable range might be from a few centimeters to several meters.", "In a preferred example, the sensor 744 can discretely detect an object touching the sensor (D=0) and distances D1 to D4.In this example, D1 could equal 5 cm, D2=10 cm, D3=20 cm and D4=30cm.", "In FIG.", "23, assume the FOV's 750 and 752 are at D2 of FIG.", "22.An object traveling along diagonal path 760 (lower left to upper right) would be detected first by sensor 744 and next by sensor 746 in a unique configuration.", "Similarly, an object traveling along vertical path 762 or horizontal path 764 would have a unique detection scheme.", "It can be seen that by having spaced apart, multiple depth sensors that can accurately measure objects at different distances, a number of commands are available.", "It is also true that depth sensors can determine object configuration very accurately.", "E.g.", "a depth sensor can discern fist configuration, e.g.", "the difference between a closed fist, a fist with 2 fingers, and a 5 finger fist, etc.", "Further, depth sensors can determine the speed of travel of an object.", "That is, the speed of a hand traveling along paths 760, 762, or 764 can be determined and different commands differentiated by speed of travel.", "There are many types of touch gestures that can be utilized in the present invention.", "In addition to the gesture interfaces available in connection with the glasses of FIG.", "10 and disclosed in the cited related art incorporated herein, Craig Villamor, Dan Willis, and Luke Wroblewski, details dozens of actions and how they work in their Definitive Guide On Gestures, e.g.", "at https://www.lukew.com/ff/entry.asp?1071.Gestures may consist of hand placement or motion and also object recognition (optionally combined with have movement) such as fist configuration.", "As used herein a “gesture” can be a hand or arm or head movement, or a fist configuration or a combination of movement and configuration.", "These are some of the most common user gestures: Tap: Touch surface briefly Double tap: Touch surface with two quick motions (often to zoom) Drag: Move along surface without breaking contact Pinch/spread: Touch surface with two fingers to move in (pinch) or out (spread) Press: Touch surface and hold Flick: Scrolls quickly In addition, many types of gesture guides have been published and are well known.", "See e.g., Oblong G-speak; Leap Motion https://developer.leapmotion.com/documentation/v2/csharp/devguide/Leap Gestures.html; Google Project Soli https://www.dezeen.com/2015/06/02/google-project-soli-interaction-sensor-radar-hand-gestures-digital-control-eletronic-devices/; http://ieeexplore.ieee.org/document/6649963/ A few general, non-limiting examples will illustrate how gestural commands of the glasses 700 of FIG.", "19 can be useful in a variety of contexts.", "In the “Girls Night Out” example 5 above, all of Jane's friends, both physically present and remote, are wearing glasses 700 of FIG.", "19.At times of their choosing, each girl operates makes gestural commands along the port temple, adjacent sensors 710, 712, 714.The sensors control operation of RGB camera 702.A tap at sensor 710 selects photo, while a tap at sensor 714 selects video.", "A drag in the forward direction from 714 to 710 initiates image capture into the Watch Me application 110.The Stories application 112 (FIG.", "4) is opened by a forward flick in the direction from 714 to 710.A backward flick in the direction from 710 to 714 spaced at D2 posts the image to the Stories application 112.Camera application 108 (FIG.", "4) is connected to a remote 360′ camera via Bluetooth on Jane's glasses 700.Jane can initiate operation of the 360′ camera at any time by a gesture command, e.g.", "a closed fist at position D3 adjacent sensor 714.Betty has positioned her phone 10 on a table with the front facing camera 140 oriented towards her.", "Betty waves her open hand in front of her face in the field of view of the phone sensors 146, 148.The sensors are configured to operate on gestures from D2-D4, and Betty's wave is within that range.", "The open hand wave selects camera 140.A second wave within 10 seconds with the fist configured with 2 fingers initiates camera 140 operation 2 seconds after the command.", "Betty gives a closed fist up and down motion and the image is posted to the Stories application 112.Turning to FIG.", "24, a sport boat 800 configured for “wake surfing” is depicted.", "See, https://en.wikipedia.org/wiki/Wakesurfing See e.g., U.S. Pat.", "Nos.", "8,578,873; 8,539,897; 8,534,214; 8,833,286; 9,067,644; 9,643,697; 9,446,823; 9,802,684; 9,315,235 (incorporated by reference).", "Generally speaking, alternatively operating port surf gate 802 or starboard surf gate 804 changes the surf from the port to the starboard sides of the boat 800.Additionally, activating the center plate 806, or changing the ballast between port and starboard tanks 808 and 810 changes the nature of the surf wake.", "Further, the speed of the boat 800 and the music being played are some of the primary functions the surfer wants to control.", "As an example, the surfer behind the boat 800 is wearing glasses 730 of FIGS.", "20 and 21.A tap at sensor 740 selects photo, while a tap at sensor 742 selects video.", "A drag in the forward direction at distance in the range 0-D2 from 740 to 742 initiates image capture into the Watch Me application 110.The Stories application 112 (FIG.", "4) is opened by a forward flick at distance in the range 0-D2 in the direction from 740 to 742.A backward flick at distance in the range 0-D2 in the direction from 742 to 740 spaced at D2 posts the image to the Stories application 112.The surfer waves his open hand horizontally in front of his face in the field of view of the sensors 744, 746.The sensors are configured to operate on gestures from D1-D3, set for a range of 1″-12″ in this example.", "The open hand wave selects camera 748.A second wave with the fist configured with 2 fingers initiates camera 748 operation.", "The surfer gives a closed fist up and down motion and the image is posted to the Stories application 112 of FIG.", "4.In a similar fashion, 180′ camera 812 is mounted on the transom of the boat 800.Operation is controlled by the depth sensors 744, 746 of the glasses 730 in a similar fashion.", "However, the surfer waves his open hand vertically in front of his face in the field of view of the sensors 744, 746 to select camera 812.The operation of the boat is activated by the depth sensors on the port side of the glasses 730.For example, tapping the aft sensor activated the port surf gate 802, while tapping the forward sensor, activates the starboard surf gate 804.A forward flick from aft sensor to forward sensor increases boat speed in increments of 2 mph.", "Conversely, a backward flick from forward port sensor to aft port sensor decreases speed in increments of 2 mph.", "A vertical open fist left hand movement at D1-D3 (1″-12″) activates the center plate 806.Up moves the plate 806 up, and downward movement moves the plate down.", "The examples herein are only for illustration purposes.", "The glasses of the present invention can be used to operate a wide variety devices in addition to cameras, boats and smart phones.", "For example, a surgeon or dentist can utilize glasses hereof to operate equipment.", "Drones or home automation can be controlled by the glasses hereof.", "While the operation of a sporting event is illustrated in conjunction with boating (FIG.", "24), almost any sport can benefit from use of the glasses hereof, including biking, sailing, skiing, hiking, car or motorcycle riding or racing, etc." ] ]
Patent_15874096
[ [ "3D NAND DEVICE WITH FIVE-FOLDED MEMORY STACK STRUCTURE CONFIGURATION", "A three-dimensional semiconductor device includes an alternating stack of insulating layers and electrically conductive layers located over a substrate, memory stack structures extending through the alternating stack and arranged in at least five rows that extend along a first horizontal direction, contact via structures arranged in a same number of rows as the memory stack structures and overlying the memory stack structures, each of the contact via structures being electrically connected to a semiconductor channel of a respective memory stack structure, bit lines contacting a respective contact via structure and extending along a second horizontal direction that is different from the first horizontal direction, and a pair of wall-shaped via structures extending through the alternating stack and laterally extending along the first horizontal direction." ], [ "1.A three-dimensional semiconductor device comprising: an alternating stack of insulating layers and electrically conductive layers located over a substrate; memory stack structures extending through the alternating stack and arranged in at least five rows that extend along a first horizontal direction; contact via structures arranged in a same number of rows as the memory stack structures and overlying the memory stack structures, each of the contact via structures being electrically connected to a semiconductor channel of a respective memory stack structure; bit lines contacting a respective contact via structure and extending along a second horizontal direction that is different from the first horizontal direction, and arranged as a periodic array of bit lines having a bit line pitch along the first horizontal direction; and a pair of wall-shaped via structures extending through the alternating stack, and laterally extending along the first horizontal direction, wherein the at least five rows of memory stack structures are located between pair of wall-shaped via structures.", "2.The three-dimensional semiconductor device of claim 1, wherein a geometrical center of each contact via structure is laterally offset along the first horizontal direction from a geometrical center of each contact via structure in any adjacent row of the contact via structures by at least twice the bit line pitch; and wherein each subset of the memory stack structures within a same row is arranged as a periodic one-dimensional array having a memory stack structure pitch along the first horizontal direction.", "3.The three-dimensional semiconductor device of claim 2, wherein the memory stack structure pitch is the same as a product of the bit line pitch and a total number of rows of the memory stack structures between the pair of wall-shaped via structures.", "4.The three-dimensional semiconductor device of claim 1, further comprising drain regions, each of the drain regions contacting a top end of a vertical semiconductor channel within a respective memory stack structure and electrically shorted to a respective contact via structure.", "5.The three-dimensional semiconductor device of claim 1, wherein each of the memory stack structures comprises, from outside to inside, memory elements, a tunneling dielectric, and a vertical semiconductor channel.", "6.The three-dimensional semiconductor device of claim 1, wherein the memory stack structures extending through the alternating stack are arranged in exactly five rows.", "7.The three-dimensional semiconductor device of claim 1, wherein the contact via structures are elongated along the second horizontal direction.", "8.The three-dimensional semiconductor device of claim 1, wherein: the three-dimensional semiconductor device comprises a vertical NAND device located over the substrate; the electrically conductive layers comprise, or are electrically connected to, a respective word line of the vertical NAND device; the substrate comprises a silicon substrate; the vertical NAND device comprises an array of monolithic three-dimensional NAND strings located over the silicon substrate; at least one memory cell in a first device level of the three-dimensional array of NAND strings is located over another memory cell in a second device level of the three-dimensional array of NAND strings; the silicon substrate contains an integrated circuit comprising a driver circuit for the memory device located thereon; and the array of monolithic three-dimensional NAND strings comprises: a plurality of semiconductor channels, wherein at least one end portion of each of the plurality of semiconductor channels extends substantially perpendicular to a top surface of the substrate; a plurality of charge storage elements, each charge storage element located adjacent to a respective one of the plurality of semiconductor channels; and a plurality of control gate electrodes having a strip shape extending substantially parallel to the top surface of the substrate, the plurality of control gate electrodes comprise at least a first control gate electrode located in the first device level and a second control gate electrode located in the second device level.", "9.A three-dimensional semiconductor device comprising: an alternating stack of insulating layers and electrically conductive layers located over a substrate; memory stack structures extending through the alternating stack and arranged in a first two-dimensional hexagonal array including at least five rows that extend along the first horizontal direction; and contact pillars arranged in a same number of rows as the memory stack structures and overlying the memory stack structures, each of the contact pillars being electrically connected to a semiconductor channel of a respective memory stack structure, wherein: a first subset of contact pillars including contact pillars located between outermost rows is arranged in a second two-dimensional hexagonal array that is commensurate with a portion of the first two-dimensional hexagonal array; and a geometrical center of each contact pillar in a second subset of contact pillars including contact pillars located at the outermost rows is laterally offset from an axis passing through a geometrical center of a respective underlying memory stack structure.", "10.The three-dimensional semiconductor device of claim 9, further comprising a pair of wall-shaped via structures extending through the alternating stack, and laterally extending along a first horizontal direction, wherein the memory stack structures are located between the pair of wall-shaped via structures.", "11.The three dimensional semiconductor device of claim 9, further comprising contact via structures arranged in a same number of rows as the memory stack structures and overlying the contact pillars, each of the contact via structures contacting an underlying contact pillar; and further comprising bit lines contacting a respective contact via structure and extending along a second horizontal direction that is different from the first horizontal direction, wherein each of the bit lines is electrically shorted to a respective drain region.", "12.The three-dimensional semiconductor device of claim 11, wherein the bit lines are arranged as a periodic array of bit lines having a bit line pitch along the first horizontal direction.", "13.The three-dimensional semiconductor device of claim 12, wherein a geometrical center of each contact via structure is laterally offset along the first horizontal direction from a geometrical center of each contact via structure in any adjacent row of the contact via structures by at least twice the bit line pitch.", "14.A three-dimensional NAND device comprising: an alternating stack of word lines separated by insulator layers extending in a word line direction; at least five rows of memory holes each containing a vertical semiconductor channel and a memory film, the rows extending in the word line direction between a pair of adjacent slit trenches; and a plurality of bit lines extending in a bit line direction and electrically connected to the semiconductor channels.", "15.The three-dimensional NAND device of claim 14, wherein adjacent bit lines are not electrically connected to semiconductor channels in nearest neighbor memory holes.", "16.The three-dimensional NAND device of claim 14, wherein the device has at least a five-folded configuration comprising at least five rows of memory holes in each memory block." ], [ "<SOH> BACKGROUND <EOH>Recently, ultra high density storage devices have been proposed using a three-dimensional (3D) stacked memory structure sometimes referred to as a Bit Cost Scalable (BiCS) architecture.", "For example, a 3D NAND stacked memory device can be formed from an array of alternating conductive and dielectric layers.", "A memory opening is formed through the layers to define many memory layers simultaneously.", "A NAND string is then formed by filling the memory opening with appropriate materials.", "A straight NAND string extends in one memory opening, while a pipe- or U-shaped NAND string (p-BiCS) includes a pair of vertical columns of memory cells.", "Control gates of the memory cells may be provided by the conductive layers." ], [ "<SOH> SUMMARY <EOH>According to an aspect of the present disclosure, a three-dimensional semiconductor device comprises an alternating stack of insulating layers and electrically conductive layers located over a substrate, memory stack structures extending through the alternating stack and arranged in at least five rows that extend along a first horizontal direction, contact via structures arranged in a same number of rows as the memory stack structures and overlying the memory stack structures, each of the contact via structures being electrically connected to a semiconductor channel of a respective memory stack structure, bit lines contacting a respective contact via structure and extending along a second horizontal direction that is different from the first horizontal direction, and arranged as a periodic array of bit lines having a bit line pitch along the first horizontal direction, and a pair of wall-shaped via structures extending through the alternating stack, and laterally extending along the first horizontal direction, wherein the at least five rows of memory stack structures are located between pair of wall-shaped via structures.", "In one embodiment, a geometrical center of each contact via structure is laterally offset along the first horizontal direction from a geometrical center of each contact via structure in any adjacent row of the contact via structures by at least twice the bit line pitch.", "According to another aspect of the present disclosure, a three-dimensional semiconductor device comprises an alternating stack of insulating layers and electrically conductive layers located over a substrate, memory stack structures extending through the alternating stack and arranged in a first two-dimensional hexagonal array including at least five rows that extend along the first horizontal direction, and contact pillars arranged in a same number of rows as the memory stack structures and overlying the memory stack structures, each of the contact pillars being electrically connected to a semiconductor channel of a respective memory stack structure.", "A first subset of contact pillars including contact pillars located between outermost rows is arranged in a second two-dimensional hexagonal array that is commensurate with a portion of the first two-dimensional hexagonal array.", "A geometrical center of each contact pillar in a second subset of contact pillars including contact pillars located at the outermost rows is laterally offset from an axis passing through a geometrical center of a respective underlying memory stack structure.", "According to another aspect of the present disclosure a three-dimensional NAND device comprises an alternating stack of word lines separated by insulator layers extending in a word line direction, at least five rows of memory holes each containing a vertical semiconductor channel and a memory film, the rows extending in the word line direction between a pair of adjacent slit trenches, and a plurality of bit lines extending in a bit line direction and electrically connected to the semiconductor channels.", "In one embodiment, adjacent bit lines are not electrically connected to semiconductor channels in nearest neighbor memory holes." ], [ "FIELD The present disclosure relates to the field of semiconductor devices, and specifically to three-dimensional semiconductor devices, such as vertical NAND strings and other three-dimensional devices, and methods of making the same.", "BACKGROUND Recently, ultra high density storage devices have been proposed using a three-dimensional (3D) stacked memory structure sometimes referred to as a Bit Cost Scalable (BiCS) architecture.", "For example, a 3D NAND stacked memory device can be formed from an array of alternating conductive and dielectric layers.", "A memory opening is formed through the layers to define many memory layers simultaneously.", "A NAND string is then formed by filling the memory opening with appropriate materials.", "A straight NAND string extends in one memory opening, while a pipe- or U-shaped NAND string (p-BiCS) includes a pair of vertical columns of memory cells.", "Control gates of the memory cells may be provided by the conductive layers.", "SUMMARY According to an aspect of the present disclosure, a three-dimensional semiconductor device comprises an alternating stack of insulating layers and electrically conductive layers located over a substrate, memory stack structures extending through the alternating stack and arranged in at least five rows that extend along a first horizontal direction, contact via structures arranged in a same number of rows as the memory stack structures and overlying the memory stack structures, each of the contact via structures being electrically connected to a semiconductor channel of a respective memory stack structure, bit lines contacting a respective contact via structure and extending along a second horizontal direction that is different from the first horizontal direction, and arranged as a periodic array of bit lines having a bit line pitch along the first horizontal direction, and a pair of wall-shaped via structures extending through the alternating stack, and laterally extending along the first horizontal direction, wherein the at least five rows of memory stack structures are located between pair of wall-shaped via structures.", "In one embodiment, a geometrical center of each contact via structure is laterally offset along the first horizontal direction from a geometrical center of each contact via structure in any adjacent row of the contact via structures by at least twice the bit line pitch.", "According to another aspect of the present disclosure, a three-dimensional semiconductor device comprises an alternating stack of insulating layers and electrically conductive layers located over a substrate, memory stack structures extending through the alternating stack and arranged in a first two-dimensional hexagonal array including at least five rows that extend along the first horizontal direction, and contact pillars arranged in a same number of rows as the memory stack structures and overlying the memory stack structures, each of the contact pillars being electrically connected to a semiconductor channel of a respective memory stack structure.", "A first subset of contact pillars including contact pillars located between outermost rows is arranged in a second two-dimensional hexagonal array that is commensurate with a portion of the first two-dimensional hexagonal array.", "A geometrical center of each contact pillar in a second subset of contact pillars including contact pillars located at the outermost rows is laterally offset from an axis passing through a geometrical center of a respective underlying memory stack structure.", "According to another aspect of the present disclosure a three-dimensional NAND device comprises an alternating stack of word lines separated by insulator layers extending in a word line direction, at least five rows of memory holes each containing a vertical semiconductor channel and a memory film, the rows extending in the word line direction between a pair of adjacent slit trenches, and a plurality of bit lines extending in a bit line direction and electrically connected to the semiconductor channels.", "In one embodiment, adjacent bit lines are not electrically connected to semiconductor channels in nearest neighbor memory holes.", "BRIEF DESCRIPTION OF THE DRAWINGS FIGS.", "1A-1F are sequential vertical cross-sectional views of a exemplary structure containing a NAND string at various steps for forming an overlying metal interconnect structure according to an embodiment of the present disclosure.", "FIG.", "2 is a perspective view of a cut-out portion of the exemplary structure according to an embodiment of the present disclosure.", "FIG.", "3 is a perspective view of a cut-out portion of an exemplary structure, according to an embodiment of the present disclosure.", "FIG.", "4A is a plan view of a region of a reference configuration illustrating overlay between bit lines, contact pillars, and contact via structures.", "FIGS.", "4B and 4C are plan views of a region of the reference configuration illustrating numbering of contact pillars according to respective associated bit line numbers and spacing between various elements.", "FIG.", "5A is a plan view of a region of a first exemplary configuration illustrating overlay between bit lines, contact pillars, and contact via structures according to an embodiment of the present disclosure.", "FIG.", "5B is a plan view of a region of the first exemplary configuration illustrating numbering of contact pillars according to respective associated bit line numbers.", "FIG.", "6 shows a comparison of pitches and edge offsets for bit lines between the reference configuration and the first exemplary configuration.", "FIG.", "7 illustrates a second exemplary configuration for the contact pillars and contact via structures according to an embodiment of the present disclosure.", "FIG.", "8 illustrates geometrical components of the second exemplary configuration according to an embodiment of the present disclosure.", "DETAILED DESCRIPTION As discussed above, the present disclosure is directed to three-dimensional semiconductor devices, such as vertical NAND strings and other three-dimensional devices, and methods of making the same, the various aspects of which are described below.", "The embodiments of the disclosure can be employed to form various semiconductor devices such as three-dimensional monolithic memory array devices comprising a plurality of NAND memory stack structures.", "The drawings are not drawn to scale.", "Multiple instances of an element may be duplicated where a single instance of the element is illustrated, unless absence of duplication of elements is expressly described or clearly indicated otherwise.", "Ordinals such as “first,” “second,” and “third” are employed merely to identify similar elements, and different ordinals may be employed across the specification and the claims of the instant disclosure.", "The drain regions of the memory cells are connected to bit lines through contact via structures.", "The present inventors realized that capacitive coupling between the bit lines and the contact via structures contributes to the total parasitic capacitance of the bit lines.", "The greater the capacitive coupling between the bit lines and the contact via structures to the drain regions, the greater the parasitic capacitance of the bit lines and the RC delay of the bit lines.", "Further, the present inventors realized that the parasitic capacitance can be reduced by forming low dielectric constant dielectric materials, a vacuum cavity, or an air cavity over the contact via structures.", "A monolithic three dimensional memory array is one in which multiple memory levels are formed above a single substrate, such as a semiconductor wafer, with no intervening substrates.", "The term “monolithic” means that layers of each level of the array are directly deposited on the layers of each underlying level of the array.", "In contrast, two dimensional arrays may be formed separately and then packaged together to form a non-monolithic memory device.", "For example, non-monolithic stacked memories have been constructed by forming memory levels on separate substrates and vertically stacking the memory levels, as described in U.S. Pat.", "No.", "5,915,167 titled “Three Dimensional Structure Memory.” The substrates may be thinned or removed from the memory levels before bonding, but as the memory levels are initially formed over separate substrates, such memories are not true monolithic three dimensional memory arrays.", "The various three dimensional memory devices of the present disclosure include a monolithic three-dimensional NAND string memory device, and can be fabricated employing the various embodiments described herein.", "Referring to FIG.", "1A, a first exemplary structure according to a first embodiment of the present disclosure includes a first exemplary structure, which includes a three-dimensional semiconductor device.", "Specifically, the three-dimensional semiconductor device can contain a monolithic, three-dimensional array of NAND strings that includes a monolithic three-dimensional NAND string located over a substrate 8.The substrate 8 can include a substrate semiconductor layer 10.In one embodiment, the substrate 8 can be a silicon substrate.", "Optionally, additional material layers (not shown) may be present underneath the substrate 8.The substrate 8 can be a bulk semiconductor substrate, in which case the entirety of the substrate 8 is a semiconductor substrate.", "Alternatively, the substrate 8 can be a top semiconductor layer of a semiconductor-on-insulator (SOI) substrate or a top semiconductor material portion a hybrid substrate including at least one bulk semiconductor region and at least one SOI region.", "In this case, the substrate semiconductor layer 10 can be the top semiconductor layer of an SOI substrate, a semiconductor material layer in a bulk portion, or a top semiconductor portion of in an SOI region of a hybrid substrate.", "The substrate semiconductor layer 10 is a semiconductor material layer, and can include at least one elemental semiconductor material (such as silicon), at least one III-V compound semiconductor material, at least one II-VI compound semiconductor material, at least one organic semiconductor material, or other semiconductor materials known in the art.", "The substrate 8 has a major surface 9, which can be, for example, a topmost surface of the substrate semiconductor layer 10.The major surface 9 can be a semiconductor surface.", "In one embodiment, the major surface 9 can be a single crystalline semiconductor surface.", "As used herein, a “semiconductor material” refers to a material having a resistivity in the range from 1.0×10−5 Ohm-cm to 1.0×105 Ohm-cm, and is capable of producing a doped material having a resistivity in a range from 1.0×10−5 Ohm-cm to 1.0 Ohm-cm upon suitable doping with an electrical dopant.", "As used herein, an “electrical dopant” refers to a p-type dopant that adds a hole to a balance band within a band structure, or an n-type dopant that adds an electron to a conduction band within a band structure.", "As used herein, a “major surface” refers to a planar surface having a greater area than at least another surface that may be another planar surface or a curved surface.", "As used herein, a planar surface is a surface that is contained within a Euclidean two-dimensional plane or deviating from a Euclidean two-dimensional plane only by variations caused by surface bowing and/or surface roughness of a magnitude inherently present in commercially available semiconductor substrates.", "The substrate semiconductor layer 10 can include a single crystalline semiconductor material, a polycrystalline semiconductor material, and/or an amorphous semiconductor material.", "In one embodiment, the substrate semiconductor layer 10 can be a single crystalline semiconductor material layer.", "In one embodiment, the substrate semiconductor layer 10 can include a single crystalline silicon layer, a single crystalline silicon-germanium alloy layer, or a single crystalline silicon-carbon alloy layer.", "Alternately or additionally, the substrate semiconductor layer 10 can include a polycrystalline silicon layer, a polycrystalline silicon-germanium alloy layer, or a polycrystalline silicon-carbon alloy layer.", "Portions of the substrate semiconductor layer 10 can be suitably doped with p-type dopants or n-type dopants.", "Source regions or drain regions can be formed as doped portions of the substrate semiconductor layer 10, i.e., by doping portions of the substrate semiconductor layer 10 with p-type dopants or n-type dopants.", "In one embodiment, the doped regions can be formed as source regions for monolithic three-dimensional NAND string memory devices.", "Each memory stack structure 20 includes memory cells embedded within an alternating stack 30 of insulator layers 32 and electrically conductive layers 34, which can be control gate electrodes for the monolithic three-dimensional NAND string memory devices.", "Optionally, select gate electrodes such as source-side select gate electrodes (not shown) can be formed within, or on top of, the substrate semiconductor layer 10 employing any suitable material.", "For example, a lower select gate device level may be fabricated as described in U.S. patent application Ser.", "No.", "14/133,979, filed on Dec. 19, 2013, U.S. patent application Ser.", "No.", "14/225,116, filed on Mar.", "25, 2014, and/or U.S. patent application Ser.", "No.", "14/225,176, filed on Mar.", "25, 2014, all of which are incorporated herein by reference.", "The alternating stack 30 includes alternately stacked insulator layers 32 and electrically conductive layers 34.The insulator layers 32 include a first material, which is an electrically insulating material (e.g., interlevel insulating material).", "The electrically conductive layers 34 include a second material, which is a conductive material.", "Electrically insulating materials that can be employed for the insulator layers 32 include, but are not limited to, silicon oxide (including doped or undoped silicate glass), silicon nitride, silicon oxynitride, organosilicate glass (OSG), spin-on dielectric materials, dielectric metal oxides, dielectric metal oxynitrides, low dielectric constant dielectric materials such as organosilicate glass, dielectric oxides (e.g., aluminum oxide, hafnium oxide, etc.)", "and silicates thereof, and organic insulating materials.", "Conductive materials that can be employed for the electrically conductive layers 34 include, but are not limited to, a doped semiconductor material, elemental metals, intermetallic alloys, conductive nitrides of at least one elemental metal, a silicate of at least one metal, conductive carbon allotropes, organic conductive materials, and combinations thereof.", "For example, the second material of the electrically conductive layers 34 can be doped polysilicon, tungsten, tungsten nitride, tantalum, tantalum nitride, titanium, titanium nitride, cobalt, copper, aluminum, an alloy thereof, or a combination thereof.", "In one embodiment, the insulator layers 32 can include silicon oxide or organosilicate glass, and the electrically conductive layers 34 can include doped polysilicon or doped amorphous silicon that can be subsequently converted into doped polysilicon through a thermal anneal at an elevated temperature.", "The first material of the insulator layers 32 can be deposited, for example, by chemical vapor deposition (CVD).", "For example, if undoped silicate glass or doped silicate glass is employed for the insulator layers 32, tetraethyl orthosilicate (TEOS) can be employed as the precursor material for the CVD process.", "The second material of the electrically conductive layers 34 can be deposited, for example, by physical vapor deposition (PVD; sputtering), chemical vapor deposition, electroplating, electroless plating, or combinations thereof.", "Alternatively, the second material of the electrically conductive layers 34 can be deposited by formation of an alternating stack of the insulator layers 32 and sacrificial material layers (e.g., silicon nitride layers or polysilicon layers), selective removal of the sacrificial material layer with respect to the insulator layers 32 to form lateral recesses, and deposition of a conductive material within the recesses, for example, by chemical vapor deposition.", "As used herein, “selective removal” of a first material with respect to a second material refers to removal of the first material selective to the second material.", "As used herein, removal of a first material is “selective to” a second material if the removal process removes the first material at a rate that is at least twice the rate of removal of the second material.", "The ratio of the rate of removal of the first material to the rate of removal of the second material is herein referred to as a “selectivity” of the removal process for the first material with respect to the second material.", "The electrically conductive layers 34 can be suitably patterned to function as the control gate electrodes of the monolithic three-dimensional NAND string memory devices to be subsequently formed.", "The electrically conductive layers 34 may comprise a portion having a strip shape extending substantially parallel to the major surface 9 of the substrate 8.The thicknesses of the insulator layers 32 and the electrically conductive layers 34 can be in a range from 15 nm to 100 nm, although lesser and greater thicknesses can be employed for each insulator layer 32 and for each electrically conductive layer 34.The topmost layer among the insulator layers 32 may have a greater thickness than underlying insulator layers 32.The number of repetitions of the pairs of an insulator layer 32 and an electrically conductive layer 34 can be in a range from 2 to 1,024, and typically from 8 to 256, although a greater number of repetitions can also be employed.", "An array of memory openings can be formed through the alternating stack 30 by a combination of lithographic methods and at least one anisotropic etch.", "For example, a photoresist layer (not shown) can be formed over the alternating stack 30 and lithographically patterned to form a plurality of openings therein by lithographic exposure and development.", "The pattern in the photoresist layer can be transferred through the alternating stack 30 and optionally into an upper portion of the substrate semiconductor layer 10 by at least one anisotropic etch to form an array of memory opening, i.e., openings that are subsequently employed to form an array of memory elements.", "The chemistry of the anisotropic etch process employed to etch through the materials of the alternating stack 30 can alternate to optimize etching of the first and second materials in the alternating stack 30.The anisotropic etch can be, for example, a series of reactive ion etches.", "Optionally, a sacrificial etch stop layer (not shown) may be employed between the alternating stack 30 and the substrate 8.The sidewalls of the memory openings can be substantially vertical, or can be tapered.", "In one embodiment, an overetch into the substrate semiconductor layer 10 can be optionally performed after the top surfaces of the substrate semiconductor layer 10 are physically exposed.", "The overetch can form recesses underneath the memory holes from a horizontal plane including the major surface 9 of the substrate 8, i.e., from the top surface of the substrate semiconductor layer 10.The recess depth can be, for example, in a range from 1 nm to 50 nm, although lesser and greater recess depths can also be employed.", "The overetch is optional, and may be omitted.", "Each of the memory openings can include a sidewall (or a plurality of sidewalls) that extends substantially perpendicular to the major surface 9 of the substrate 8, and is defined by the physically exposed sidewall surfaces of the alternating stack 30.In one embodiment, the sidewalls of the recessed portions of the substrate semiconductor layer 10 can be vertically coincident with the sidewalls of the memory openings.", "As used herein, a first surface is “vertically coincident” with a second surface if there exists a vertical plane including both the first surface and the second surface.", "Such a vertical plane may, or may not, have a horizontal curvature, but does not include any curvature along the vertical direction, i.e., extends straight up and down.", "A memory film layer, a semiconductor channel layer, and optionally, a dielectric fill material layer can be sequentially deposited in the memory openings and over the alternating stack 30.The memory film layer can include a stack, from one side to another, of a blocking dielectric layer, a charge storage layer, and a tunnel dielectric layer.", "Thus, the blocking dielectric layer, the charge storage layer, the tunnel dielectric layer, the semiconductor channel layer, and the optional dielectric fill material layer can be sequentially deposited to fill the memory holes.", "The blocking dielectric layer may include one or more dielectric material layers that can function as the dielectric material(s) of a control gate dielectric between the electrically conductive layers 34 and charge storage regions to be subsequently formed out of the charge storage layer.", "The blocking dielectric layer can include silicon oxide, a dielectric metal oxide, a dielectric metal oxynitride, or a combination thereof.", "The charge storage layer includes a charge trapping material, which can be, for example, silicon nitride or a conductive material such as doped polysilicon or a metallic material.", "In one embodiment, the charge storage layer includes silicon nitride.", "The charge storage layer can be formed as a single charge storage layer of homogeneous composition, or can include a stack of multiple charge storage material layers.", "The multiple charge storage material layers, if employed, can comprise a plurality of spaced-apart floating gate material layers that contain conductive materials and/or semiconductor materials.", "Alternatively or additionally, the charge storage layer may comprise an insulating charge trapping material, such as one or more silicon nitride segments.", "Alternatively, the charge storage layer may comprise conductive nanoparticles such as metal nanoparticles, which can be, for example, ruthenium nanoparticles.", "The tunnel dielectric layer includes a dielectric material through which charge tunneling can be performed under suitable electrical bias conditions.", "The charge tunneling may be performed through hot-carrier injection or by Fowler-Nordheim tunneling induced charge transfer depending on the mode of operation of the monolithic three-dimensional NAND string memory device to be formed.", "The tunneling dielectric layer can include silicon oxide, silicon nitride, silicon oxynitrides, dielectric metal oxides (such as aluminum oxide and hafnium oxide), dielectric metal oxynitrides, dielectric metal silicates, alloys thereof, and/or combinations thereof.", "The semiconductor channel layer includes a polycrystalline semiconductor material or an amorphous semiconductor material that can be subsequently annealed at an elevated temperature to form a polycrystalline semiconductor material.", "Semiconductor materials that can be employed for the semiconductor channel layer include, but are not limited to, silicon, germanium, a silicon-germanium alloy, a silicon-carbon alloy, a silicon-germanium-carbon alloy, a III-V compound semiconductor material, a II-VI compound semiconductor material, an organic semiconductor material, or a combination thereof.", "The semiconductor channel layer can be formed by a conformal deposition process such as chemical vapor deposition (CVD) or atomic layer deposition (ALD).", "The thickness of the semiconductor channel layer can be in a range from 3 nm to 30 nm, although lesser and greater thicknesses can also be employed.", "The semiconductor channel layer can include a doped semiconductor material.", "The doped semiconductor material can be p-doped or n-doped, i.e., doped with p-type electrical dopants or n-type electrical dopants.", "Optionally, the dielectric fill material layer includes a dielectric material such as silicon oxide, organosilicate glass (OSG), a spin-on dielectric material, a low-k dielectric material having a dielectric constant less than 3.0, or a combination thereof.", "In one embodiment, the dielectric fill material layer includes undoped silicon oxide.", "The dielectric fill material layer can be deposited, for example, by chemical vapor deposition and/or by spin coating.", "The amount of the deposited dielectric material for the dielectric fill material layer is selected such that the entire cavity of each memory opening is filled with the deposited dielectric material.", "Portions of the blocking dielectric layer, the memory film layer, and the optional dielectric fill material layer can be removed above the top surface of the alternating stack 30, for example, by chemical mechanical planarization (CMP), a recess etch, or a combination thereof.", "Each remaining portion of the memory film layer within a memory hole constitutes a memory film 22.Each remaining portion of the semiconductor channel layer in a memory opening constitutes a vertical semiconductor channel 24.Each remaining portion of the dielectric fill material layer within a memory hole constitutes a dielectric core 26.An adjoining set of a memory film 22, a vertical semiconductor channel 24, and a dielectric core 26 collectively constitutes a memory stack structure 20, which is a vertical column of memory elements.", "As used herein, a memory element is a structure capable of storing information for a memory bit (a “0” or “1”).", "In one embodiment, a section of a memory film 22 and a section of a vertical semiconductor channel 24 within one level in proximity to a control gate electrode located at one level, in conjunction with the control gate electrode, constitute a memory element or a “memory cell.” A vertical stack of memory elements constitutes a memory stack structure 20, which is a memory stack structure.", "In one embodiment, the array of memory stack structures 20 can be an array of NAND strings.", "Top portions of the dielectric cores 26 can be recessed to form cavities by an etch that is selective to the dielectric material of the topmost insulator layer 32.In one embodiment, the etch can be selective to the vertical semiconductor channels 24.A doped semiconductor material portion is formed within each cavity to form drain regions 58.Each drain region 58 contacts a vertical semiconductor channel 24.The vertical semiconductor channels 24 can be intrinsic or doped.", "If the vertical semiconductor channels 24 are doped, the source regions (not shown) in the substrate semiconductor layer 10 and the drain regions 58 within the memory openings can have a conductivity type that is the opposite of the conductivity type of the vertical semiconductor channels 24.For example, if the vertical semiconductor channels 24 include a p-doped semiconductor material, the source regions and the drain regions 58 can have n-doped semiconductor materials.", "If the vertical semiconductor channels 24 include an n-doped semiconductor material, the source regions and the drain regions 58 can have p-doped semiconductor materials.", "Alternately, the source regions (not shown) in the substrate semiconductor layer 10 and the drain regions 58 within the memory openings can have the same conductivity type as the vertical semiconductor channels 24.In one embodiment, the topmost surface of each drain region 58 can be coplanar with the top surface of the topmost insulator layer 32.The bottommost surface of each drain region 58 can be located above a horizontal plane including the bottommost surface of topmost insulator layer 32.The first exemplary structure contains a three-dimensional semiconductor device including an array of unit device structures over a substrate 8.Each of the unit device structures can include a memory stack structure 20 and a drain region 58.Each memory stack structure 20 includes a vertical semiconductor channel 24 having at least a portion extending along a vertical direction perpendicular to a top surface of the substrate 8.Each drain region 58 contacts a top end of the vertical semiconductor channel 24.The three-dimensional semiconductor device further comprises an alternating stack 30 of insulator layers 32 and electrically conductive layers 34 (which can be control gate electrodes) that laterally surround the plurality of memory stack structures 20.In one embodiment, the substrate 8 can comprise a silicon substrate, and the three-dimensional semiconductor device can comprise a monolithic, three-dimensional array of NAND strings that includes a monolithic three-dimensional NAND string located over the silicon substrate.", "For example, at least one memory cell that is located in a first device level of the three-dimensional array of NAND strings can be located over another memory cell in a second device level of the three-dimensional array of NAND strings.", "The silicon substrate can contain an integrated circuit comprising a driver circuit for the at least one memory cell.", "Backside trenches extending through the alternating stack 30 can be provided to form respective wall-shaped via structures 176 therein.", "Each backside trench can have a uniform width and can laterally extend along a first horizontal direction.", "Thus, each wall-shaped via structure 176 can have a form of a plate having a substantially uniform thickness that is invariant along the first horizontal direction.", "Each wall-shaped via structure 176 can have a vertical sidewall, or can have a taper along the vertical direction.", "A source region 12 can be formed at the bottom of each backside trench.", "In one embodiment, the source regions 12 can have the same conductivity type as the drain regions 58.In one embodiment, the source regions 12 and the drain regions 58 can be p-doped regions.", "In another embodiment, the source regions 12 and the drain regions 58 can be n-doped regions.", "A semiconductor channel is provided between each drain region 58 and an adjacent source region 12.Each semiconductor channel includes a vertical semiconductor channel 24 and a horizontal semiconductor channel that is a portion of the substrate semiconductor layer 10 between a bottommost portion of the vertical semiconductor channel 24 and the adjacent source region 12.An insulating spacer 174 can be formed within each backside trench, for example, by conformal deposition of an insulating material layer and an anisotropic etch.", "Each remaining portion of the conformal insulating material layer at a periphery of the respective backside trench constitutes an insulating spacer 174.At least one conductive material is deposited into remaining volumes of the backside trenches to form backside contact via structures 176, which can contact the respective source regions 12.Each backside contact via structure 176 can laterally extend along the first horizontal direction.", "The memory stack structures 20 can be arranged in groups that are located between adjacent pairs of backside contact via structures 176.Thus, a group of memory stack structures 20 can be provided between each adjacent pair of backside contact via structures 176.Each group of memory stack structures 20 between an adjacent pair of backside contact via structures 176 can be arranged in an array configuration.", "In one embodiment, each group of memory stack structures 20 between an adjacent pair of backside contact via structures 176 can be arranged as rows of memory stack structures 20 that are periodically positioned along the first lengthwise direction.", "In one embodiment, the rows of memory stack structures 20 can have a uniform pitch along a second horizontal direction, which can be perpendicular to the first horizontal direction.", "In one embodiment, the rows of memory stack structures 20 can form a hexagonal periodic array such that the axis of each memory stack structure 20 (i.e., a vertical line that passes through the geometrical center of the respective memory stack structure 20) are at vertices of a hexagonal array in a plan view (i.e., as viewed top-down).", "In one embodiment, the number of rows of the memory stack structures 20 between each adjoining pair of wall-shaped via structures 176 can be 4, 5, 6, 7, 8, 9, 10, 11, or 12.In one embodiment, the number of rows of the memory stack structures 20 between each adjoining pair of wall-shaped via structures 176 can be 5 to provide advantage in avoiding electrical shorts, which is described below.", "An overlying metal interconnect structure can be formed over the array of memory stack structures 20.For example, at least one dielectric material layer can be optionally formed over the top surfaces of the alternating stack 30 and the array of memory stack structures 20.The at least one dielectric material layer deposited on the top surface of the alternating stack is herein referred to as at least one pillar-level dielectric cap layer (61, 63).", "Each of the at least one pillar-level dielectric cap layer (61, 63) is a dielectric material layer that is formed at the pillar level.", "As used herein, a “pillar level” refers to a level including contact pillars that contact the drains 58 of the memory stack structures 20.As used herein, a “pillar-level” element refers to an element that is formed at the location of the pillar level.", "The at least one pillar-level dielectric cap layer (61, 63) functions as at least one cap layer that covers the entirety of the alternating stack 30, the array of memory stack structures 20, and the drain regions 58.Each of the at least one pillar-level dielectric cap layer (61, 63) is a dielectric material layer that is present at the pillar level.", "Alternatively, the at least one pillar-level dielectric cap layer (61, 63) may be omitted.", "In one embodiment, the at least one pillar-level dielectric cap layer (61, 63) can include a first pillar-level dielectric cap layer 61 containing a first dielectric material and a second pillar-level dielectric cap layer 63 containing a second dielectric material.", "At least one of the first and second dielectric materials can be selected to be an etch stop material during a subsequent process that removes a sacrificial dielectric layer from above the second dielectric material.", "In one embodiment, the first dielectric material can be silicon oxide or organosilicate glass (OSG), and the second dielectric material can be silicon nitride or nitrogen-doped organosilicate glass.", "In one embodiment, each of the first and second pillar-level dielectric cap layers (61, 63) can have a thickness in a range from 3 nm to 60 nm, although lesser and greater thicknesses can also be employed.", "A dielectric material layer is formed over the first and second pillar-level dielectric cap layers (61, 63).", "The dielectric material layer is herein referred to as a pillar-level dielectric material layer 64.The pillar-level dielectric material layer 64 can be formed over the at least one pillar level dielectric cap layer (61, 63) or over the alternating stack 30 in case the at least one pillar level dielectric cap layer (61, 63) is not present.", "The pillar-level dielectric material layer 64 can be formed by chemical vapor deposition or spin coating.", "The thickness of the pillar-level dielectric material layer 64 can be in a range from 200 nm to 1,000 nm, although lesser and greater thicknesses can also be employed.", "In one embodiment, the pillar-level dielectric material layer can have a dielectric material having a dielectric constant in a range from 3.0 to 3.9 such as silicon oxide based dielectric material.", "Exemplary dielectric materials having a dielectric constant in a range from 3.0 to 3.9 include undoped silicate glass and various doped silicate glasses.", "In one embodiment, the pillar-level dielectric material layer 64 can have a dielectric constant less than 3.0.In one embodiment, low-k dielectric material of the pillar-level dielectric material layer 64 can be a material selected from fluorinated glass, hydrogen silsesquioxane, alkyl silsesquioxane, a spin-on aromatic polymer, polyimide, fluorinated polyimide, doped or undoped parylene, a B-stage polymer, doped or undoped diamond-like carbon, diamond-like carbon, doped or undoped amorphous carbon, polytetrafluoroethylene (PTFE), xerogel, aerogel, and porous variants thereof.", "Subsequently, a photoresist layer (not shown), and optionally an antireflective coating layer (not shown), can be formed over the top surface of the pillar-level dielectric material layer 64, and is lithographically patterned to form an array of openings therein.", "The pattern of the openings can be substantially the same as the pattern of contact pillars to be subsequently formed.", "The pattern in the photoresist layer is transferred through the pillar-level dielectric material layer 64 and the at least one pillar-level dielectric cap layer (61, 63), if present, to form a plurality of pillar cavities 66.Referring to FIG.", "1B, a plurality of contact pillars 68 can be formed within the plurality of pillar cavities 66 by depositing a conductive material within the pillar cavities 66 and over the top surface of the pillar-level dielectric material layer 64, and subsequently removing the portion of the deposited conductive material from above the top surface of the pillar-level dielectric material layer 64.The same conductive material can be employed to form the plurality of contact pillars 68 as in the first and second embodiments of the present disclosure.", "Further, the same method can be employed to deposit and planarize the conductive material as in the first and second embodiments of the present disclosure.", "The plurality of conductive pillars 68 can be formed through the pillar-level dielectric material layer 64 and at least one pillar-level dielectric cap layer (61, 63), if present, and directly on the drain regions 58.Each of the plurality of contact pillars 68 can have a horizontal cross-sectional shape that is invariant under translation along the vertical direction.", "In one embodiment, each of the plurality of contact pillars 68 can have a substantially cylindrical shape.", "Alternatively, the plurality of contact pillars 68 can have shapes of inverted frustums.", "A pillar-level structure is formed, which includes a plurality of contact pillars 68 and a contiguous volume of a homogeneous composition filled by the pillar-level dielectric material layer 64.The pillar-level dielectric material layer 64 laterally surrounds the plurality of contact pillars 68, which is contact with the drain regions 58.The contiguous volume of the pillar-level dielectric material layer 64 is located above the topmost surface of at least one pillar-level dielectric cap layer (61, 63) contacting bottom portions of the plurality of contact pillars 68.The dielectric constant of the contiguous volume (which may, or may not, have a homogeneous composition), i.e., of the pillar-level dielectric material layer 64, can be equal to, or less than, 3.9.In one embodiment, the dielectric constant of the pillar-level dielectric material layer 64 can be less than 3.0 The contiguous volume of the homogeneous composition can comprise a remaining portion of the pillar-level dielectric material layer 64 after formation of the plurality of pillars 68.If the pillar-level dielectric material layer 64 includes undoped silicate glass, the dielectric constant of the pillar-level dielectric material layer 64 can be about 3.9.If the pillar-level dielectric material layer 64 includes fluorinated glass, the dielectric constant of the pillar-level dielectric material layer 64 can be about 2.8.If the pillar-level dielectric material layer 64 includes silsesquioxane or alkyl silsesquioxane, the dielectric constant of the pillar-level dielectric material layer 64 can be about 2.7.If the pillar-level dielectric material layer 64 includes a spin-on aromatic polymer, the dielectric constant of the pillar-level dielectric material layer 64 can be about 2.0.If the pillar-level dielectric material layer 64 includes polyimide, the dielectric constant of the pillar-level dielectric material layer 64 can be about 2.9.If the pillar-level dielectric material layer 64 includes fluorinated polyimide, the dielectric constant of the pillar-level dielectric material layer 64 can be about 2.3.If the pillar-level dielectric material layer 64 includes doped or undoped parylene, the dielectric constant of the pillar-level dielectric material layer 64 can be about 2.7.If the pillar-level dielectric material layer 64 includes a B-stage polymer, the dielectric constant of the pillar-level dielectric material layer 64 can be about 2.6.If the pillar-level dielectric material layer 64 includes doped or undoped diamond-like carbon, diamond-like carbon, or doped or undoped amorphous carbon, the dielectric constant of the pillar-level dielectric material layer 64 can be about 2.7.If the pillar-level dielectric material layer 64 includes polytetrafluoroethylene (PTFE), the dielectric constant of the pillar-level dielectric material layer 64 can be about 1.9.If the pillar-level dielectric material layer 64 includes a highly porous dielectric oxide material such as xerogel or aerogel, the dielectric constant of the pillar-level dielectric material layer 64 can be from about 1.8 to about 2.5.Porous version of any non-porous dielectric material generally provides a lower dielectric constant than the non-porous dielectric material.", "Referring to FIG.", "1C, a via-level dielectric cap layer 73 can be deposited over the top surface of the pillar-level dielectric material layer 64.The via-level dielectric cap layer 73 is a dielectric material layer that is formed in the via level, and can be employed as an etch stop layer during subsequent formation of via cavities.", "The via-level dielectric cap layer 73 can include silicon oxide, organosilicate glass (OSG), silicon nitride, nitrogen-doped organosilicate glass, or a stack thereof.", "In one embodiment, the via-level dielectric cap layer 73 can have a thickness in a range from 3 nm to 60 nm, although lesser and greater thicknesses can also be employed.", "The via-level dielectric cap layer 73 is a cover insulating layer, i.e., a dielectric material layer located in the via level.", "The contiguous bottom surface of the via-level dielectric cap layer 73 contacts a planar top surface of the pillar-level dielectric material layer 64.A dielectric material layer can be formed over the via-level dielectric cap layer 73.The dielectric material layer can include a low dielectric constant material having a dielectric constant less than 3.9, which is the dielectric constant of silicon oxide.", "In this case, the dielectric material layer formed over the via-level dielectric cap layer 73 is herein referred to as a via-level dielectric material layer 74.The via-level dielectric material layer 74 can have a dielectric constant less than 3.9.In one embodiment, the via-level dielectric material layer 74 can have a dielectric constant less than 3.0.In one embodiment, low-k dielectric material of the via-level dielectric material layer 74 can be selected from any dielectric material that can be employed for the low-k dielectric material of the pillar-level dielectric material layer 64.A photoresist layer (not shown), and optionally an antireflective coating layer (not shown), can be formed over the top surface of the via-level dielectric material layer 74, and is lithographically patterned to form an array of openings therein.", "The pattern of the openings can be substantially the same as the pattern of contact via structures to be subsequently formed.", "The pattern in the photoresist layer is transferred through the via-level dielectric material layer 74 and the via-level dielectric cap layer 73 to form a plurality of via cavities 76.A top surface of a contact pillar 68 can be physically exposed at the bottom of each via cavity 76.In one embodiment, each of the plurality of via cavities 76 can have a tapered shape, or can have a substantially cylindrical shape.", "Alternatively, the plurality of via cavities 76 can have shapes of inverted frustums.", "Referring to FIG.", "1D, a plurality of contact via structures 78 can be formed within the plurality of via cavities 76.The plurality of contact via structures 78 can be formed on the top surfaces of the plurality of contact pillars 68 and through the via-level dielectric material layer 74 and the via-level dielectric cap layer 73.Each of the plurality of contact via structures 78 contacts a respective one of the plurality of contact pillars 68.The conductive materials that can be employed to form the plurality of contact via structures 78 can be the same as in the first and second embodiments.", "The deposition and planarization of the conductive material can be performed employing the same processing steps as in the first and second embodiments.", "Referring to FIG.", "1E, a line-level dielectric cap layer 83 can be deposited over the top surface of the via-level dielectric material layer 64.The line-level dielectric cap layer 83 is a dielectric material layer that is formed in the line level, and can be employed as an etch stop layer during subsequent formation of line cavities.", "The line-level dielectric cap layer 83 can include silicon oxide, organosilicate glass (OSG), silicon nitride, nitrogen-doped organosilicate glass, or a stack thereof.", "In one embodiment, the line-level dielectric cap layer 83 can have a thickness in a range from 3 nm to 60 nm, although lesser and greater thicknesses can also be employed.", "The line-level dielectric cap layer 83 is a line-level dielectric layer, i.e., a dielectric material layer located in the line level.", "The contiguous bottom surface of the line-level dielectric cap layer 83 contacts can contact a planar top surface of the via-level dielectric material layer 74.A dielectric material layer can be formed over the line-level dielectric cap layer 83.The dielectric material layer can include a low dielectric constant material having a dielectric constant less than 3.9, which is the dielectric constant of silicon oxide.", "In this case, the dielectric material layer formed over the line-level dielectric cap layer 83 is herein referred to as a line-level low-k dielectric material layer 84.The line-level low-k dielectric material layer 84 can have a dielectric constant less than 3.9.In one embodiment, the line-level low-k dielectric material layer 84 can have a dielectric constant less than 3.0.In one embodiment, low-k dielectric material of the line-level low-k dielectric material layer 84 can be selected from any dielectric material that can be employed for the low-k dielectric material of the pillar-level dielectric material layer 64 or the via-level dielectric material layer 74.A photoresist layer (not shown), and optionally an antireflective coating layer (not shown), can be formed over the top surface of the line-level low-k dielectric material layer 84, and is lithographically patterned to form an array of openings therein.", "The pattern of the openings can be substantially the same as the pattern of bit lines to be subsequently formed.", "The pattern in the photoresist layer is transferred through the line-level low-k dielectric material layer 84 and the line-level dielectric cap layer 83 to form a plurality of line cavities 86.A top surface of a contact via structure 78 can be physically exposed at the bottom of each line cavity 86.In one embodiment, each of the plurality of line cavities 86 can have a substantially rectangular vertical cross-sectional shape.", "Referring to FIG.", "1F, a plurality of bit lines 88 can be formed within the plurality of line cavities 86.The plurality of bit lines 88 can be formed on the top surfaces of the plurality of contact via structures 78 and through the line-level low-k dielectric material layer 84 and the line-level dielectric cap layer 83.Each of the plurality of bit lines 88 contacts a respective one of the plurality of contact via structures 78.The plurality of bit lines 88 is formed on the topmost portions of the plurality of contact via structures 78.The plurality of bit lines 88 laterally extends along a same horizontal direction.", "The conductive material that fills the plurality of line cavities 86 can be the same as in the first embodiment.", "A dielectric material can be conformally or non-conformally deposited over the plurality of bit lines 88 to form a capping dielectric layer 93.The capping dielectric layer 93 can include any of the dielectric material that can be employed for the at least one pillar-level dielectric cap layer (61, 63), the via-level dielectric cap layer 73, or the line-level dielectric cap layer 83.Methods employed for deposition of the at least one pillar-level dielectric cap layer (61, 63), the via-level dielectric cap layer 73, or the line-level dielectric cap layer 83 can be employed to form the capping dielectric layer 93.Alternatively, integrated line and via structures can be formed in lieu of each combination of a bit line 88 and at least one contact via structure 78 contacting the bit line 88.Referring to FIGS.", "2 and 3, perspective views of a cut-out portion of the exemplary structure are shown.", "The various dielectric material layers between the at least one pillar-level dielectric cap layer (61, 63) and the capping dielectric layer 93 are not shown for clarity.", "Optionally, a passivation dielectric layer 95 can be formed above the capping dielectric layer 93.The structures of the various embodiments of the present disclosure can provide low parasitic capacitance between the bit lines 88 and the plurality of contact pillars 68 due to the presence of the contiguous volume of a homogeneous composition that laterally surrounds the plurality of contact pillars 68 within a pillar-level structure.", "The reduction in the parasitic capacitance can reduce the RC delay of the bit lines 88 (or the integrated line and via structures), and increase the speed of operation of the device structure, which can include an array of vertical memory stacks, which can be, for example, a monolithic, three-dimensional array of NAND strings.", "It is understood that the configuration of the bit lines 88 with respect to the underlying contact pillars 68 and contact via structures 78 can be implemented in configurations in which cavities are introduced within the pillar-level dielectric material layer 64 and the pillar-level dielectric material layer 74.The embodiments described above can be combined to include an air gap or a low-k dielectric material associated with any one or more of contact pillars 68, contact via structures 78, and/or bit lines.", "Thus, the embodiments include any combination of an air gap or a low-k dielectric material for any given level.", "One embodiment includes an air gap or a low-k dielectric material surrounding contact pillars 68 and contact via structures 78, and located in between bit lines 88.Another embodiment includes an air gap or a low-k dielectric material surrounding contact pillars 68 and contact via structures 78, and located in between bit lines 88.Another embodiment includes an air gap or a low-k dielectric material only surrounding contact pillars 68, and contact via structures 78, but not located in between bit lines 88.Another embodiment includes an air gap or a low-k dielectric material surrounding contact pillars 68 and located in between bit lines 88, but not surrounding contact via structures 78.Another embodiment includes an air gap or a low-k dielectric material surrounding contact via structures 78, and located in between bit lines 88 but not surrounding contact pillars 68.Another embodiment includes an air gap or a low-k dielectric material only surrounding contact pillars 68.Another embodiment includes an air gap or a low-k dielectric material only surrounding contact via structures 78.Each row 200 of memory stack structures 20 is located between a pair of wall-shaped via structures 176, which can contact an electrically conductive region within the substrate 10.The wall-shaped via structures 176 can be located in slit trenches that laterally extend along the first horizontal direction.", "In one embodiment, the slit trenches can extend to a top surface of the substrate 8.In this case, the wall-shaped via structures 176 can be conductive structures that function as source contact electrodes (e.g., source local interconnects), which contact a respective source region 12 in the substrate 8.In one embodiment, the slit trenches extend only through upper electrically conductive layers 34 (which may correspond to upper select gate electrodes such as drain-select gate electrodes).", "In this case, the well-shaped via structures 176 can be dielectric structures consisting essentially of dielectric materials.", "The electrically conductive layers 34 can be control gate electrodes (e.g., word line fingers) that extend in the word line direction (which can be the same as the first horizontal direction) between each pair of wall-shaped via structures 176.The word line direction is perpendicular to the bit line direction (which is the second horizontal direction).", "FIGS.", "4A, 4B and 4C illustrate a reference configuration, which is a 4-folded memory stack structure layout.", "In other words, there are four rows 200 of memory stack structures 20 extending in the word line direction (the first horizontal direction) between each pair of adjacent slit trenches, which may include wall-shaped via structures 176.MH refers to memory stack structures 20, and CH refers to contact pillars 68.While the bit lines 88 extend along the second horizontal direction over, and beyond, the wall-shaped via structures 176, the bit lines 88 are shown only between the pair of wall-shaped via structures 176 for simplicity.", "Each bit line 88 is labeled with an identifier 88##, in which ## represents a double digit number that uniquely identifies each bit line and ranges from 00 to 11, corresponding to the 12 bit lines that are connected to 12 memory stack structures within three instances of unit cells UC, one of which is illustrated in FIG.", "4A.", "Each contact pillar 68 is electrically shorted to only one bit line 88, and the double digit numbers ## that uniquely identifies each bit line 88 and each respective contact pillar 68 shorted to the respective bit line 88 are shown in FIG.", "4B.", "Thus, there are four rows of memory stack structures 20 extending through each word line finger, which is a portion of an electrically conductive layer 34 located between the adjacent pair of slit trenches.", "In one non-limiting aspect of a 4-folded memory stack structure layout, a unit cell UC includes sections of four bit lines 88, four respective contact via structures 78, four respective contact pillars 68, and four respective memory stack structures 20, which are electrically connected to the respective five bit lines 88.Each unit cell is located between a pair of wall-shaped via structures 176 and can be repeated as a one-dimensional periodic array along the first horizontal direction.", "In this layout, the effective memory cell size is determined as follows: Effective memory cell size=p×q/(R×N), in which, p=memory stack structure pitch along the first horizontal direction (i.e., in the word line direction), q=the width of the memory block region between the adjacent wall-shaped via structures 176 in the second horizontal direction (i.e., in the bit line direction), R=the number of rows of memory stack structures between geometrical centers of the adjacent pair of wall shaped contact via structures, and N=the total number of word lines as implemented by the electrically conductive layers 34.For cost reduction, memory cell size reduction is desired.", "To reduce the memory cell size, p and/or q can be decreased, and/or R and N can be increased.", "Reduction of p increases the probability of electrical shorts among the contact via structures 78, which are herein referred to as “V1 shorts,” or “first via level shorts.” The reason for the V1 shorts is due to smaller distance between diagonally adjacent contact via structures 78 located around minimum V1 spacing regions 75, which has the shortest distance for adjoining pairs of contact via structures 78, as shown in FIGS.", "4A and 4C.", "In contrast, V1-V1 spacing in other regions is much larger for other adjacent pairs of contact via structures 78.For example, as shown in FIG.", "4C, when p is 140 nm, the V1-V1 spacing along the first horizontal direction can be about 17.5 nm in the minimum V1 spacing regions.", "In the above calculation, the lateral dimension of each contact via structure 78 and the lateral spacing between the contact via structures 78 along the first horizontal direction are assumed to be the same, i.e., 140 nm/8 for both the lateral dimension of a contact via structure 78 along the first horizontal direction and for the spacing along the first horizontal direction.", "In contrast, the spacing for adjacent pairs of contact via structures 78 along the first horizontal direction outside of the minimum V1 spacing region 75 is about 52.5 nm.", "Each bit lines (8800-8811) contacts, and is electrically connected to, only one contact via structure 78 between the pair of wall-shaped via structures 176.Each contact via structure 78 contacts, and is electrically connected to, only one contact pillar 68 between the pair of wall-shaped via structures 176.In one embodiment, an entire area of each contact via structure 78 can overlap top surface of an underlying pillar structure 68.Each contact pillar 68 contacts, and is electrically connected to, an underlying memory stack structure 20.In the configuration illustrated in FIGS.", "4A and 4C, bit lines 8803 and 8804 are prone to electrical shorts through the pair of underlying contact via structures 78 separated by a minimum V1 spacing region 75.Other four-folded geometrical arrangements of contact via structures 78 that employs four rows of memory stack structures 20, four rows of contact pillars 68, and four rows of contact via structures 78 necessary results in formation of minimum V1 spacing regions 75 at different regions.", "In other words, for any four folded memory stack structure pattern, there will be adjacent pairs of contact via structures 78 that are separated by less than the pitch of the contact pillars, and thus, regions that are prone to electrical shorts at the level of the contact via structures 78.Referring to FIGS.", "5A and 5B, a configuration according to an embodiment of the present disclosure is illustrated, which is a 5-folded memory stack structure layout.", "In other words, there are five rows 200 of memory stack structures 20 extending in the word line direction (the first horizontal direction) between each pair of adjacent slit trenches, which may include wall-shaped via structures 176.While the bit lines 88 extend along the second horizontal direction over, and beyond, the wall-shaped via structures 176, the bit lines 88 are shown only between the pair of wall-shaped via structures 176 for simplicity.", "Each bit line 88 is labeled with an identifier 88##, in which ## represents a double digit number that uniquely identifies each bit line and ranges from 00 to 14, corresponding to the 15 bit lines that are connected to 16 memory stack structures within three instances of unit cells UC, one of which illustrated in FIG.", "5A.", "Each contact pillar 68 is electrically shorted to only one bit line 88, and the double digit numbers ## that uniquely identifies each bit line 88 and each respective contact pillar 68 shorted to the respective bit line 88 are shown in FIG.", "5B.", "Thus, there are five rows of memory stack structures 20 extending through each word line finger, which is a portion of an electrically conductive layer 34 located between the adjacent pair of slit trenches.", "In one non-limiting aspect of a 5-folded memory stack structure layout, a unit cell UC includes sections of five bit lines 88, five respective contact via structures 78, five respective contact pillars 68, and five respective memory stack structures 20, which are electrically connected to the respective five bit lines 88.Each unit cell is located between a pair of wall-shaped via structures 176 and can be repeated as a one-dimensional periodic array along the first horizontal direction.", "Thus, the NAND memory device has at least a five-folded configuration comprising at least five rows of memory holes filled with a channel 24 and memory film 22 in each memory block between adjacent trenches.", "Each bit lines (8800-8815) contacts, and is electrically connected to, only one contact via structure 78 between the pair of wall-shaped via structures 176.Each contact via structure 78 contacts, and is electrically connected to, only one contact pillar 68 between the pair of wall-shaped via structures 176.In one embodiment, an entire area of each contact via structure 78 can overlap top surface of an underlying pillar structure 68.Each contact pillar 68 contacts, and is electrically connected to, an underlying memory stack structure 20.Within each unit cell UC, five bit lines 88 extend over five memory stack structures 20, five contact pillars 68, and five contact via structures 78.Only one of the five bit lines 88 is electrically connected to any given contact pillar 68 and an underlying memory stack structure 20.The five-fold memory stack structure can be modified to form six-fold, seven-fold, eight-fold, nine-fold, or ten-fold memory stack structures by adding another instance of CH/MH row 1 between CH/MH row 5 and the adjacent wall-shaped via structure 176, adding additional instances of CH/MH row 1 and CH/MH row 2 in that order between CH/MH row 5 and the adjacent wall-shaped via structure 176, adding additional instances of CH/MH row 1, CH/MH row 2, and CH/MH row 3 in that order between CH/MH row 5 and the adjacent wall-shaped via structure 176, or adding additional instances of CH/MH rows 1-4 in that order between CH/MH row 5 and the adjacent wall-shaped via structure 176, or adding additional instances of CH/MH rows 1-5 in that order between CH/MH row 5 and the adjacent wall-shaped via structure 176, respectively.", "According to an aspect of the present disclosure, a three-dimensional semiconductor device is provided, which includes an alternating stack of insulating layers 32 and electrically conductive layers 34 located over a substrate 8, memory stack structures 20 extending through the alternating stack and arranged in at least five rows 200 that extend along a first horizontal direction, contact via structures 78 arranged in a same number of rows as the memory stack structures 20 and overlying the memory stack structures 20 such that each of the contact via structures 78 is electrically connected to a semiconductor channel 24 of a respective memory stack structure 20, and bit lines 88 contacting a respective contact via structure 78 and extending along a second horizontal direction that is different from the first horizontal direction, and arranged as a periodic array of bit lines 88 having a bit line pitch bp along the first horizontal direction, as shown in FIG.", "6.A geometrical center of each contact via structure 78 is laterally offset along the first horizontal direction from a geometrical center of each contact via structure 78 in any adjacent row of the contact via structures 78 by at least twice the bit line pitch bp.", "In one embodiment, adjacent bit lines are not electrically connected to semiconductor channels in nearest neighbor memory holes.", "In one embodiment, the three-dimensional semiconductor device can include a pair of wall-shaped via structures 176 (which can be conductive structures such as source contact structures as illustrated in FIG.", "1A, or may be dielectric structures) extending through the alternating stack, optionally contacting the substrate 8, and laterally extending along the first horizontal direction.", "The memory stack structures 20 can be located between pair of wall-shaped via structures 176.Each subset of the memory stack structures 20 that is located within a same row may be arranged as a periodic one-dimensional array having a memory stack structure pitch p along the first horizontal direction.", "In one embodiment, the memory stack structure pitch p can be the same as a product of the bit line pitch bp and the total number of rows 200 of the memory stack structures 20 between the pair of wall-shaped via structures 176.In other words, for a five-folded configuration with five rows 200, five bit lines 88 are located in the area of one pitch p in the first horizontal direction, for a six-folded configuration with five rows 200, six bit lines 88 are located in the area of one pitch p in the first horizontal direction, etc.", "In one embodiment, the three-dimensional semiconductor device can include drain regions 58.Each of the drain regions 58 can contact a top end of a vertical semiconductor channel 24 within a respective memory stack structure 20 and can be electrically shorted to a respective contact via structure 78.In one embodiment, the three-dimensional semiconductor device can include contact pillars 68.Each of the contact pillars 68 can contact a top surface of a respective drain region 58 and a bottom surface of a respective contact via structure 78.In one embodiment, the entirety of the memory stack structures 20 can be arranged in a two-dimensional hexagonal array.", "In other words, the axes of the memory stack structures 20 can be located at vertices of a two-dimensional hexagonal array in a plan view.", "In one embodiment, the entirety of the contact pillars 68 can be arranged as a two-dimensional hexagonal array that is commensurate with the two-dimensional hexagonal array of the memory stack structures as illustrated in FIGS.", "5A and 5B.", "Referring to FIG.", "6, the reference configuration of FIGS.", "4A and 4B and the embodiment configuration of FIGS.", "5A and 5B are illustrated for cases employing the same memory stack structure pitch p of 140 nm along the first horizontal direction.", "The bit line pitch bp is 35 nm for the reference configuration because four bit lines 88 are located within the memory stack structure pitch p of 140 nm.", "The bit line pitch bp is 28 nm for the embodiment configuration because five bit lines 88 are located within the memory stack structure pitch of 140 nm.", "Despite the decrease in the bit line pitch bp in the embodiment configuration relative to the reference configuration, the minimum spacing between contact via structures 78 along the first horizontal direction (i.e., the V1-V1 spacing along the first horizontal direction) increases.", "In case the width of the contact via structures 78 is one half of the bit line pitch in both configurations, the minimum spacing between contact via structures 78 along the first horizontal direction is 42 nm for the embodiment configuration, and is 17.5 nm for the reference configuration.", "Thus, use of the five-folded memory stack configuration results in an increase in the minimum spacing between contact via structures 78 along the first horizontal direction with respect to the four-folded memory stack configuration.", "The increase in the minimum spacing between contact via structures 78 along the first horizontal direction provides a larger lithography margin for patterning the contact via structures 78, thereby avoiding V1-V1 shorts.", "Generally speaking, the five-folded memory stack structure configuration can provide a minimum spacing between contact via structures 78 along the first horizontal direction (i.e., a minimum V1-V1 spacing along the first horizontal direction) that is greater than the bit line pitch bp.", "In one embodiment, the five-folded memory stack structure configuration can provide a minimum spacing between contact via structures 78 along the first horizontal direction that is about 3/2 of the bit line pitch bp.", "FIG.", "6 illustrates a feature of the embodiment configuration of the present disclosure.", "For the 4-folded memory stack structure layout shown on the left of FIG.", "6, each contact via structure 78 can be positioned within an area in proximity to the geometrical center of an underlying contact pillar 68.In an optimized version of the 4-folded memory stack structure layout of FIG.", "4A, the edge offset distance eod between the geometrical center of any contact pillar 68 and a proximal sidewall (i.e., a sidewall that is closer to the geometrical center of the contact pillar 68) of the overlying, and contacting, bit line 88 can be about 8.75 nm.", "For an optimized version of the 5-folded memory stack structure layout of FIG.", "5A (shown on the right of FIG.", "6), the edge offset distance eod between the geometrical center of any contact pillar 68 and a proximal sidewall (i.e., a sidewall that is closer to the geometrical center of the contact pillar 68) of the overlying, and contacting, bit line 88 can be about 21 nm for some of the contact via structures 78.Furthermore, the bit line pitch, bp, is decreased from 35 nm in the four-folded configuration to a 28 nm in the five-folded configuration.", "It should be noted that all of the dimensions described above are exemplary and provided for illustration of one hypothetical example, and should not be considered limiting on the scope of the claims.", "Referring to FIGS.", "7 and 8, an embodiment of the present disclosure is illustrated, which increases the lithography margin for printing the pattern for the contact via structures 78.An n-folded memory stack structure configuration can be employed in which n is an integer not less than 5, e.g., 5, 6, 7, 8, 9, 10, 11, or 12, etc.", "The contact pillars 68 in the outermost rows 201 can be laterally shifted by a lateral offset distance lod along the first horizontal direction with respect the underlying memory stack structure 20 and with respect to the overlying contact via structure 78.The contact pillars 68 in the outermost rows 201 can also be laterally shifted by a lateral offset distance lod along the first horizontal direction with respect to the contact pillars in the middle rows 200.In an illustrative example, each contact pillar 68 in the outermost rows 201 can be laterally shift distance lod can be within 10% to 50% of the bit line pitch bp.", "For example, the lateral offset distance lod can be in a range from 5 to 15 nm, such as 10 nm.", "The direction of the lateral offset distance lod can be along the word line direction (i.e., along the first horizontal direction) that is perpendicular to the bit line direction (i.e., the second horizontal direction).", "The introduction of a finite lateral offset distance lod can mitigate the overlay requirement between the contact pillars 68 and the contact via structures 78 by reducing the maximum value of the edge offset distance eod described in FIG.", "6.Specifically, the contact pillars 68 in the outermost rows 201 can be shifted along the direction that reduces the edge offset distance along the first horizontal direction.", "In this case, the contact pillars 68 can be offset along the first horizontal direction with respect to the underlying periodic structures (which may be hexagonal periodic structures) of the memory stack structures 20, and with respect to the overlying contact via structures 78.In this case, the geometrical centers of any triplet of geometrically adjacent contact pillars 68 within rows 200 excluding the outermost rows 201 can form isosceles triangles T1, i.e., triangles having two equal sides.", "Correspondingly, the lateral separation distance along the first horizontal direction between the apexes of each isosceles triangle can be either one half of the memory stack structure pitch (i.e., p/2) or the memory stack structure pitch p. The geometrical centers of any triplet of geometrically adjacent contact pillars 68 including at least one contact pillar 68 from an outermost row 201 can form scalene triangles T2, i.e., triangles having three different sides.", "As used herein, geometrically adjacent contact pillars refer to any set of contact pillars that do not include a contact pillar located between a pair of contact pillars.", "Correspondingly, the lateral separation distance along the first horizontal direction between the apexes of each scalene triangle can be the sum of one half of the memory stack structure pitch and the lateral offset distance (i.e., p/2+lod), the difference between one half of the memory stack structure pitch and the lateral offset distance (i.e., p/2−lod), or the memory stack structure pitch p. In one embodiment, the entirety of the memory stack structures 20 can be arranged in a two-dimensional hexagonal array, and a geometrical center of each contact pillar 68 overlying a subset of memory stack structures 20 located at outermost rows 201 of the memory stack structures 20 can be laterally offset from an axis passing through a geometrical center of a respective underlying memory stack structure 20 to which the contact pillar 68 is electrically connected as illustrated in FIGS.", "7 and 8.In one embodiment, each outermost row 201 of the memory stack structures 20 can be laterally offset from a hexagonal two-dimensional array formed by inner rows of the memory stack structures 20 along the first horizontal direction by a respective finite lateral offset distance lod.", "In one embodiment, the lateral offsets of two outermost rows 201 of the memory stack structures 20 can be equal in magnitude and opposite in direction as illustrated in FIG.", "7.In one embodiment, each triangle connecting neighboring geometrical centers of contact pillars 68 in rows except outermost rows 201 of the contact pillars 68 in a plan view can forms an isosceles triangle T1, and each triangle connecting neighboring geometrical centers of contact pillars 68 in an outermost row 201 and another row adjacent to the outermost row 201 in a plan view can form a scalene triangle T2.According to an aspect of the present disclosure, a three-dimensional semiconductor device is provided, which comprises an alternating stack of insulating layers 32 and electrically conductive layers 34 located over a substrate 8, memory stack structures 20 extending through the alternating stack and arranged in a first two-dimensional hexagonal array including at least five rows (200, 201) that extend along the first horizontal direction, and contact pillars 68 arranged in a same number of rows as the memory stack structures 20 and overlying the memory stack structures 20.Each of the contact pillars 68 can be electrically connected to a semiconductor channel 24 of a respective memory stack structure 20.A first subset of contact pillars 68 including contact pillars 68 located between outermost rows 201 can be arranged in a second two-dimensional hexagonal array that is commensurate with a portion of the first two-dimensional hexagonal array.", "A geometrical center of each contact pillar 68 in a second subset of contact pillars 68 including contact pillars located at the outermost rows 201 can be laterally offset from an axis passing through a geometrical center of a respective underlying memory stack structure 20.In one embodiment, the second two-dimensional hexagonal array can coincide with a portion of the first two-dimensional hexagonal array.", "In one embodiment, a pair of wall-shaped via structures 176 extending through the alternating stack, optionally contacting the substrate 8, and laterally extending along a first horizontal direction can be provided.", "The memory stack structures 20 can be located between the pair of wall-shaped via structures 176.The pair of wall-shaped via structures 176 can be a pair of source contact structures (including a conductive material as illustrated in FIG.", "1A), a pair of dielectric material portions (that can function as separators for select-drain electrodes), or a combination thereof.", "In one embodiment, the three-dimensional semiconductor device can include contact via structures 78 arranged in a same number of rows as the memory stack structures 20 and overlying the contact pillars 68.Each of the contact via structures 78 can contact an underlying contact pillar 68.Bit lines 88 can contact a respective contact via structure 78 and can extend along a second horizontal direction that is different from the first horizontal direction.", "Each of the bit lines 88 can be electrically shorted to a respective drain region 58.The bit lines 88 can be arranged as a periodic array of bit lines having a bit line pitch bp along the first horizontal direction.", "In one embodiment, the geometrical center of each contact via structure 78 can be laterally offset along the first horizontal direction from a geometrical center of each contact via structure 78 in any adjacent row 200 of the contact via structures 78 by at least twice the bit line pitch bp as illustrated in FIGS.", "5A, 5B, 7, and 8.In each embodiment of the present disclosure, each of the memory stack structures 20 can include, from outside to inside, optional blocking dielectric (which may be a portion of the memory film 22), memory elements (as embodied as portions of a memory material layer or discrete floating gate electrodes within a memory film 22), a tunneling dielectric (which is a portion of the memory film 22), and a vertical semiconductor channel 24.The memory stack structures 20 extending through the alternating stack (32, 34) can be arranged in exactly five rows or more than five rows.", "The contact via structures 78 can be elongated along the second horizontal direction.", "More than 50% of the contact via structures 78 can have a respective geometrical center that is laterally offset from an axis passing through a geometrical center of a respective underlying memory stack structure 20 (which has an areal overlap with the respective contact via structure 20).", "In each embodiment of the present disclosure, the three-dimensional semiconductor device may include a vertical NAND device located over the substrate 8.The electrically conductive layers 34 can include, or can be electrically connected to, a respective word line (as embodied as portions that surround the memory stack structures 20) of the vertical NAND device.", "The substrate 8 can comprise a silicon substrate.", "The vertical NAND device can comprise an array of monolithic three-dimensional NAND strings located over the silicon substrate.", "At least one memory cell in a first device level of the three-dimensional array of NAND strings can be located over another memory cell in a second device level of the three-dimensional array of NAND strings.", "The silicon substrate can contain an integrated circuit comprising a driver circuit for the memory device located thereon.", "The array of monolithic three-dimensional NAND strings can include a plurality of semiconductor channels, a plurality of charge storage elements, and a plurality of control gate electrodes having a strip shape extending substantially parallel to the top surface of the substrate 8.At least one end portion of each of the plurality of semiconductor channels can extend substantially perpendicular to a top surface of the substrate 8.Each charge storage element can be located adjacent to a respective one of the plurality of semiconductor channels 24.The plurality of control gate electrodes can comprise at least a first control gate electrode located in the first device level and a second control gate electrode located in the second device level.", "Electrical shorts between adjacent pairs of contact via structures for memory stack structures can be minimized by employing a configuration of five or more memory stack structures in each block of memory stack structures.", "In a configuration including five or more rows of the memory stack structures and contact via structures in each memory block, each contact via structure can be laterally spaced from other contact via structures in neighboring rows by at least twice the bit line pitch of the bit lines that contact top surfaces of the contact via structures.", "Optionally, contact pillars can be provided between the memory stack structures and the contact via structures.", "Outermost rows of the contact pillars may be laterally offset along the row direction with respect to the memory stack structures to allow increase in the lateral offset distance for outermost rows of the contact via structures.", "The embodiments of the disclosure provide the following non-limiting advantages: cell size reduction, larger process margin due to increased V1 lithography margin, and higher performance.", "The higher numbers of folded memory stack structures and smaller memory stack structure pitch p can permit the total word line length to be reduced for the same page size.", "Shorter word line length will give smaller RC delay, and read and program speed can be improved.", "Although the foregoing refers to particular embodiments, it will be understood that the disclosure is not so limited.", "It will occur to those of ordinary skill in the art that various modifications may be made to the disclosed embodiments and that such modifications are intended to be within the scope of the disclosure.", "Where an embodiment employing a particular structure and/or configuration is illustrated in the present disclosure, it is understood that the present disclosure may be practiced with any other compatible structures and/or configurations that are functionally equivalent provided that such substitutions are not explicitly forbidden or otherwise known to be impossible to one of ordinary skill in the art.", "All of the publications, patent applications and patents cited herein are incorporated herein by reference in their entirety." ] ]
Patent_15874099
[ [ "SEED DEFLECTOR AND AGITATOR FOR AN AGRICULTURAL PRODUCT DISTRIBUTION SYSTEM", "One embodiment describes a seed planting system that includes a seed storage tank to store seeds; a seed meter fluidly coupled to the seed storage tank via a flow path, in which the seed meter receives seeds from the seed storage tank and distributes the seeds to ground engaging opener assemblies; and a seed deflector coupled to the seed storage tank directly above the flow path, in which the seed deflector guides the seeds from the seed storage tank into the flow path at an angle relative to a vertical axis of the flow path." ], [ "1.A seed planting system, comprising: a seed gate assembly configured to be disposed between a seed storage tank and a seed meter, wherein the seed gate assembly comprises: a gate barrier configured to control seed flow through a flow path from the seed storage tank into the seed meter by moving between an open position and a closed position; and a first seed agitator extending substantially perpendicularly from a surface of the gate barrier; and a seed deflector positioned directly above the flow path and coupled to the gate barrier by a cable, wherein the cable is configured to actuate the seed deflector as the gate barrier moves; wherein the seed deflector and the first seed agitator are configured to dislodge clumped seeds in the seed storage tank as the gate barrier moves from the open position toward the closed position.", "2.The seed planting system of claim 1, comprising a torsional spring coupled to the seed deflector, wherein the torsional spring is configured to store rotational energy as the seed deflector is actuated by the gate barrier, and to release the rotational energy as the gate barrier moves toward the closed position.", "3.The seed planting system of claim 1, wherein the first seed agitator is configured to extend into the seed storage tank as the gate barrier moves toward the closed position to dislodge the clumped seeds.", "4.The seed planting system of claim 1, wherein the seed deflector is configured to rotate in a first direction as the gate barrier moves toward the open position, and to rotate in a second direction, opposite the first direction, as the gate barrier moves toward the closed position.", "5.The seed planting system of claim 1, wherein the seed gate assembly comprises a second seed agitator extending substantially perpendicularly from the surface of the gate barrier, and the second seed agitator is configured to extend into the seed storage tank as the gate barrier moves toward the closed position to dislodge the clumped seeds." ], [ "<SOH> BACKGROUND <EOH>The present disclosure relates generally to seed planting systems and, more particularly, to seed distribution in the seed planting system.", "Generally, a seed planting system is used to deposit seeds into soil.", "For example, in the seed planting system, an agricultural implement may include multiple rows of ground engaging opener assemblies that excavate trenches into the soil.", "The ground engaging opener assemblies may then deposit seeds into the excavated trenches.", "In this manner, rows of seeds may be planted into the soil.", "To facilitate the deposition of seeds, the seeds may be distributed to each of the ground engaging opener assemblies from a centralized storage location, such as a seed storage tank.", "More specifically, a seed meter may be used to control the seed distribution to each of the ground engaging opener assemblies from the centralized storage location.", "In other words, the storage tank may supply seeds into the seed meter for distribution.", "As such, seed distribution may be undesirable when the flow of seeds from the storage tank to the seed meter is obstructed, for example, by clumped seeds." ], [ "<SOH> BRIEF DESCRIPTION <EOH>Certain embodiments commensurate in scope with the originally claimed invention are summarized below.", "These embodiments are not intended to limit the scope of the claimed invention, but rather these embodiments are intended only to provide a brief summary of possible forms of the invention.", "Indeed, the invention may encompass a variety of forms that may be similar to or different from the embodiments set forth below.", "A first embodiment describes a seed planting system that includes a seed storage tank to store seeds; a seed meter fluidly coupled to the seed storage tank via a flow path, in which the seed meter receives seeds from the seed storage tank and distributes the seeds to ground engaging opener assemblies; and a seed deflector coupled to the seed storage tank directly above the flow path, in which the seed deflector guides the seeds from the seed storage tank into the flow path at an angle relative to a vertical axis of the flow path.", "A second embodiment describes a method for controlling actuation of a seed deflector in a seed planting system.", "The method includes determining, using a control system, that clumped seeds are at least partially obstructing a flow path between a seed storage tank and a seed meter; instructing, using the control system, a motor drive to actuate the seed deflector to dislodge the clumped seeds, in which the seed deflector is positioned directly above the flow path; determining, using the control system, that a seed gate assembly disposed in the flow path is moving from an open position to a closed position; and instructing, using the control system, the motor drive to position the seed deflector in an upright orientation to establish a seed void above the seed gate assembly that facilitates moving the seed gate assembly to the closed position.", "A third embodiment describes a seed planting system that includes a seed gate assembly disposed between a seed storage tank and a seed meter.", "The seed gate assembly includes a gate barrier that controls seed flow through a flow path from the seed storage tank into the seed meter by moving between an open position and a closed position; and a first seed agitator extending substantially perpendicularly from a surface of the gate barrier.", "The seed planting system further includes a seed deflector positioned directly above the flow path and coupled to the gate barrier by a cable, in which the cable actuates the seed deflector as the gate barrier moves.", "The seed deflector and the first seed agitator dislodge clumped seeds in the seed storage tank as the gate barrier moves from the open position toward the closed position." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application claims priority and benefit from U.S. patent application Ser.", "No.", "14/932,082, entitled “SEED DEFLECTOR AND AGITATOR FOR AN AGRICULTURAL PRODUCT DISTRIBUTION SYSTEM”, filed Nov. 4, 2015, which claims priority and the benefit of U.S.", "Provisional Application Ser.", "No.", "62/074,837, entitled “SEED DEFLECTOR AND AGITATOR FOR AN AGRICULTURAL PRODUCT DISTRIBUTION SYSTEM”, filed Nov. 4, 2014, both of which are hereby incorporated by reference in their entirety herein.", "BACKGROUND The present disclosure relates generally to seed planting systems and, more particularly, to seed distribution in the seed planting system.", "Generally, a seed planting system is used to deposit seeds into soil.", "For example, in the seed planting system, an agricultural implement may include multiple rows of ground engaging opener assemblies that excavate trenches into the soil.", "The ground engaging opener assemblies may then deposit seeds into the excavated trenches.", "In this manner, rows of seeds may be planted into the soil.", "To facilitate the deposition of seeds, the seeds may be distributed to each of the ground engaging opener assemblies from a centralized storage location, such as a seed storage tank.", "More specifically, a seed meter may be used to control the seed distribution to each of the ground engaging opener assemblies from the centralized storage location.", "In other words, the storage tank may supply seeds into the seed meter for distribution.", "As such, seed distribution may be undesirable when the flow of seeds from the storage tank to the seed meter is obstructed, for example, by clumped seeds.", "BRIEF DESCRIPTION Certain embodiments commensurate in scope with the originally claimed invention are summarized below.", "These embodiments are not intended to limit the scope of the claimed invention, but rather these embodiments are intended only to provide a brief summary of possible forms of the invention.", "Indeed, the invention may encompass a variety of forms that may be similar to or different from the embodiments set forth below.", "A first embodiment describes a seed planting system that includes a seed storage tank to store seeds; a seed meter fluidly coupled to the seed storage tank via a flow path, in which the seed meter receives seeds from the seed storage tank and distributes the seeds to ground engaging opener assemblies; and a seed deflector coupled to the seed storage tank directly above the flow path, in which the seed deflector guides the seeds from the seed storage tank into the flow path at an angle relative to a vertical axis of the flow path.", "A second embodiment describes a method for controlling actuation of a seed deflector in a seed planting system.", "The method includes determining, using a control system, that clumped seeds are at least partially obstructing a flow path between a seed storage tank and a seed meter; instructing, using the control system, a motor drive to actuate the seed deflector to dislodge the clumped seeds, in which the seed deflector is positioned directly above the flow path; determining, using the control system, that a seed gate assembly disposed in the flow path is moving from an open position to a closed position; and instructing, using the control system, the motor drive to position the seed deflector in an upright orientation to establish a seed void above the seed gate assembly that facilitates moving the seed gate assembly to the closed position.", "A third embodiment describes a seed planting system that includes a seed gate assembly disposed between a seed storage tank and a seed meter.", "The seed gate assembly includes a gate barrier that controls seed flow through a flow path from the seed storage tank into the seed meter by moving between an open position and a closed position; and a first seed agitator extending substantially perpendicularly from a surface of the gate barrier.", "The seed planting system further includes a seed deflector positioned directly above the flow path and coupled to the gate barrier by a cable, in which the cable actuates the seed deflector as the gate barrier moves.", "The seed deflector and the first seed agitator dislodge clumped seeds in the seed storage tank as the gate barrier moves from the open position toward the closed position.", "DRAWINGS These and other features, aspects, and advantages of the present invention will become better understood when the following detailed description is read with reference to the accompanying drawings in which like characters represent like parts throughout the drawings, wherein: FIG.", "1 is a side view of a seed planting system with an agricultural implement and an air cart, in accordance with an embodiment; FIG.", "2 is a schematic view of a seed meter, in accordance with an embodiment; FIG.", "3 is a side view of a seed meter, in accordance with an embodiment; FIG.", "4 is a perspective view of the seed meter of FIG.", "3, in accordance with an embodiment; FIG.", "5 is a cross-sectional view of a storage tank and a seed gate assembly, in which the seed gate is in an open position, in accordance with an embodiment; FIG.", "6 is a cross-sectional view of the storage tank and the seed gate assembly of FIG.", "5, in which the seed gate is in a closed position, in accordance with an embodiment; FIG.", "7 is a cross-sectional perspective view of the storage tank and the seed gate assembly of FIG.", "5 with a movable seed deflector, in accordance with an embodiment; FIG.", "8 is a flow diagram of a process for actuating the seed deflector, in accordance with an embodiment; and FIG.", "9 is a cross-sectional perspective view of the storage tank and the seed gate assembly of FIG.", "5 with an alternative movable seed deflector, in accordance with an embodiment.", "DETAILED DESCRIPTION One or more specific embodiments of the present disclosure will be described below.", "In an effort to provide a concise description of these embodiments, all features of an actual implementation may not be described in the specification.", "It should be appreciated that in the development of any such actual implementation, as in any engineering or design project, numerous implementation-specific decisions must be made to achieve the developers' specific goals, such as compliance with system-related and business-related constraints, which may vary from one implementation to another.", "Moreover, it should be appreciated that such a development effort might be complex and time consuming, but would nevertheless be a routine undertaking of design, fabrication, and manufacture for those of ordinary skill having the benefit of this disclosure.", "When introducing elements of various embodiments of the present disclosure, the articles “a,” “an,” “the,” and “said” are intended to mean that there are one or more of the elements.", "The terms “comprising,” “including,” and “having” are intended to be inclusive and mean that there may be additional elements other than the listed elements.", "Any examples of operating parameters and/or environmental conditions are not exclusive of other parameters/conditions of the disclosed embodiments.", "A planting system generally enables multiple rows of seeds to be deposited into soil.", "For example, the seeds may be distributed to multiple rows of ground engaging opener assemblies on an agricultural implement.", "Each of the ground engaging opener assemblies may engage the soil to excavate a trench and deposit the seeds into the trench.", "In certain configurations, the ground engaging opener assemblies do not include adjustable control over the rate of seed deposition.", "Instead, each ground engaging opener assembly may receive seeds, e.g., via a pneumatic flow through hose, and utilize gravity to deposit received seeds into a trench.", "In other words, the ground engaging opener assembly may deposit seeds based on the flow rate of seeds to the ground engaging opener assembly, among other factors.", "As such, the deposition of seeds may be controlled by the distribution of seeds to each of the ground engaging opener assemblies.", "In some embodiments, controlling the flow of seeds may enable the seed spacing and/or amount of seeds deposited to be controlled.", "For example, by decreasing the distribution rate of seeds to a ground engaging opener, the seed spacing may be increased and/or the amount of seeds deposited may be decreased.", "On the other hand, by increasing the distribution rate of seeds to a ground engaging opener, the seed spacing may be reduced and/or amount of seeds deposited may be increased.", "Generally, the seeds may be stored in and distributed from a centralized location, such as an air cart.", "More specifically, on the air cart, a storage tank may centrally store the seeds and a seed meter may control the distribution of seeds to each of the ground engaging opener assemblies.", "Thus, the storage tank and the seed meter may be fluidly coupled to enable seed flow from the storage tank into the seed meter.", "As such, the deposition of seeds may be affected when the seed flow from the storage tank into the seed meter is disturbed, for example, by an obstruction caused by clumped seeds in the storage tank.", "In some embodiments, seeds may clump due to their asymmetrical shapes, high-friction surfaces, close proximity, and/or “stickiness” due to natural fluids or treatments, among other factors.", "More specifically, clumped seeds may block seeds from flowing from the storage tank and into the seed meter, which reduces the amount of seed available for the seed meter to distribute.", "In other words, clumped seeds may cause the seed meter to distribute less than the desired amount of seeds to the ground engaging opener assemblies, thereby causing undesirable seed deposition.", "Accordingly, as will be described in more detail below, the techniques described herein may improve the reliability of the seed distribution by reducing the possibility of seed clumping.", "In one embodiment, a seed meter is fluidly coupled to a storage tank to enable the storage tank to supply seeds to the seed meter.", "In other words, a flow path may be established between the storage tank and the seed meter to enable seed flow.", "To facilitate the seed flow, a seed deflector (e.g., an umbrella seed deflector) may be included directly above the flow path.", "More specifically, the umbrella seed deflector may guide the seeds so that the seeds enter the flow path at an angle relative to the vertical axis and are less concentrated (e.g., compacted) in the flow path, thereby reducing the possibility of clumped seed.", "In fact, in some embodiments, the umbrella seed deflector may actuate to agitate the seeds, which may further reduce the possibility of clumped seeds Additionally, in some embodiments, the seed meter may include a seed gate assembly, which may be used to control the seed flow from the storage tank into the seed meter.", "More specifically, the seed gate assembly may be opened to enable the seed flow and closed to block the seed flow.", "As the seed gate assembly closes, seeds in the path of the movement of the seed gate assembly may be displaced.", "However, this movement may be difficult when the seeds are tightly compacted against the seed gate assembly.", "Accordingly, as will be described in more detail below, the techniques described herein may improve control over the seed flow by a seed gate assembly.", "In one embodiment, the umbrella seed deflector may establish a less concentrated flow of seeds through the flow path and against the seed gate assembly.", "As such, fewer seeds may be displaced as the seed gate assembly is closed, which may improve the ease and responsiveness of closing the seed gate assembly.", "To help illustrate, a side view of a planting system 10 is shown in FIG.", "1.As depicted, the planting system 10 includes an agricultural implement 11 coupled to an air cart 12.In the depicted embodiment, the air cart 12 is towed behind the agricultural implement 11.More specifically, the agricultural implement 11 may be coupled to an off-road work vehicle by a first hitch assembly (not shown), and the air cart 12 may be coupled to the agricultural implement 11 by a second hitch assembly 14.However, in other embodiments, the agricultural implement 11 may be towed behind the air cart 12.In further embodiments, the implement 11 and the air cart 12 may be part of a single unit that is towed behind an off-road work vehicle or may be elements of a self-propelled vehicle.", "As described above, the agricultural implement 11 may be used to deposit rows of seeds into the soil as the agricultural implement 11 is towed across a field by an off-road work vehicle, such as a tractor.", "Accordingly, as depicted, the agricultural implement 11 includes a tool frame 15 coupled to a ground engaging opener assembly 16, a distribution header 18, a hose 20, and wheel assemblies 22.More specifically, the wheel assemblies 22 may contact the soil surface to enable the agricultural implement 11 to be pulled by the off-road work vehicle.", "As the agricultural implement 11 is pulled, a row of seeds may be deposited into the soil by the ground engaging opener assembly 16.Although only one ground engaging opener assembly 16 is shown, the agricultural implement 11 may include multiple ground engaging opener assemblies 16 organized in a row across the agricultural implement 11.In some embodiments, the agricultural implement 11 may include a row of 12, 14, 16, 18, 20, or more ground engaging opener assemblies 16, which may each deposit a row of seeds.", "To facilitate depositing seeds, each ground engaging opener assembly 16 includes an opener 17, a press wheel 19, and a seed tube 21.More specifically, when the opener 17 engages the soil, the opener 17 may exert a downward force that excavates a trench into the soil as the ground engaging opener assembly 16 travels through the field.", "Seeds may then be deposited into the excavated trench via the seed tube 21.Then, the press wheel 19 may move the excavated soil into the trench to cover the seeds.", "As described above, the air cart 12 may centrally store seeds and distribute the seeds to the ground engaging opener assembly 16.Accordingly, as depicted, the air cart 12 includes a seed meter 24, a storage tank 26, a frame 28, wheels 30, and an air source 32.In the depicted embodiment, the air cart frame 28 is coupled to the tool frame 15 via the hitch 14.As such, the wheels 30 may contact the soil surface to enable the air cart 12 to be towed along with the agricultural implement 11.Additionally, the storage tank 26 may centrally store the seeds for distribution.", "In some embodiments, the storage tank 26 may include multiple compartments for storing different types of granular products.", "For example, a first compartment may store seeds while a second compartment may store a dry fertilizer.", "In such configurations, the air cart 12 may deliver both seed and fertilizer to the implement 10 via separate distribution systems, or as a mixture through a single distribution system.", "Generally, the distribution system may control the amount of seeds distributed to the ground engaging opener assemblies 16, for example, using the seed meter 24.As depicted, the seed meter 24 is mounted to the bottom of the storage tank 26, which may enable the storage tank 26 to supply seeds to the seed meter 24.The seed meter 24 may then distribute the seeds to the distribution header 18 via a respective hose 34.The distribution headers 18 may then distribute the seeds to one or more ground engaging opener assemblies 16 via the hose 20.In this manner, the seed meter 24 may control distribution of seeds from the storage tank 26 to the ground engaging opener assemblies 16 and into the trenches.", "In some embodiments, the seeds may be pneumatically distributed.", "To help illustrate, a schematic view of the seed meter 24 and the storage tank 26 is shown in FIG.", "2.As depicted, the air source 32 generates an air stream 36, which is guided through though the seed meter 24.In some embodiments, the air source 32 may be a pump or blower powered by an electric or hydraulic motor, for example.", "As depicted, the air stream 36 is guided so that it tangentially engages seeds 38 output from the storage tank 26.In this manner, the seeds 38 may be entrained in the air stream 36 and output from the seed meter 24.Thus, the seed meter 24 may control the flow rate of seeds 38 by controlling the flow of seeds from the storage tank 26 into the air stream 36.In the depicted embodiment, a meter roller 40 is utilized.", "More specifically, rotation of the meter roller 40 may transfer seeds 38 through an opening 42 into the air stream 36.Thus, as depicted, the meter roller 40 includes an interior cavity 44 that receives a shaft connected to a drive unit, which actuates the meter roller 40.In other embodiments, the meter roller 40 may be coupled to a wheel 30 so that rotation of the wheel 30 drives the meter roller 40 to rotate.", "Such a configuration may automatically vary the rotation rate of the meter roller 40 based on the speed of the air cart 12.Additionally, as depicted, the meter roller 40 includes multiple flutes 46 and recesses 48.More specifically, seeds 28 may be held between adjacent flutes 46 in each recess 48.Thus, as the meter roller 40 rotates, gravity may pull the seeds 38 held in a recess 48 through the opening 42 and into the air stream 36.Generally, the number and geometry of the flutes 46 may be based on the seeds 38 being distributed.", "For example, a meter roller 40 having deeper recesses 48 and fewer flutes 46 may be employed for larger seeds, while a meter roller 40 having shallower recesses 48 and more flutes 46 may be employed for smaller seeds.", "Other parameters such as flute pitch (i.e., angle relative to a longitudinal axis) and flute angle (i.e., angle relative to a radial axis) may also be particularly selected based on seed type, for example.", "Thus, the actuation of the meter roller 40 may be based upon an expectation that a certain amount of seeds are in the seed meter 24.For example, when less than the expected amount of seeds is present in the seed meter 24, each recess 48 may hold less seeds.", "As such, each rotation of the meter roller 40 may output less seeds into the air stream 36, thereby increasing seed spacing and/or decreasing amount of seeds deposited undesirably.", "As described above, multiple rows of ground engaging opener assemblies 16 may be used.", "In some embodiments, the seed meter 24 may include a single continuous meter roller 40.In such an embodiment, the seed distribution to each of the ground engaging opener assemblies 16 supplied by the seed meter 24 may be generally uniform.", "However, in other embodiments, it may be beneficial to vary distribution rates to the ground engaging opener assemblies 16.For example, when the agricultural implement 11 is turning, ground engaging opener assemblies 16 closer to the center point of the turning circle may travel a shorter distance than ground engaging opener assemblies 16 farther from the center point.", "Accordingly, to maintain uniform spacing of seeds between the rows, it may be desirable for the ground engaging opener assemblies 16 closer to the center point to deposit seeds at a slower rate than the ground engaging opener assemblies 16 farther from the center point.", "In such embodiments, the seed meter 24 may include multiple meter rollers 40 disposed adjacent to one another.", "For example, each individual meter roller 40 may be used to control seed distribution to one or more of the ground engaging opener assemblies 16.Accordingly, the seed meter 24 may include 4, 5, 6, 7, 8, 9, or more independently controllable meter rollers 40.To help illustrate, a side view of one embodiment of a seed meter 24 with ten meter rollers 40 is shown in FIG.", "3.In the depicted embodiment, each meter roller 40 may control the seed output rate through the two hose connectors 50 directly below the meter roller 40.For example, a first meter roller 40A may receive seeds from the storage tank 26 and control output of the seeds through a first hose connector 50A and a second hose connector 50B.", "More specifically, each hose connector 50 may be pneumatically coupled to a respective hose 34 to enable the air stream 36 to be delivered to the distribution header 18 or directly to a ground engaging opener assembly 16.As such, each of the meter rollers 40 may control the seed deposition by one or more ground engaging opener assemblies 16.In other words, the depicted seed meter 24 may be used to deposit ten or more rows of seeds into the soil.", "To facilitate receiving seeds from the storage tank 26, the seed meter 24 may be secured to the storage tank 26 using a seed gate assembly 52.For example, in the depicted embodiment, the seed gate assembly 52 is secured to the bottom of the storage tank using bolts 54.Accordingly, seeds may flow from the storage tank 26, though the seed gate assembly 52, and into the seed meter 24.As such, one or more sensors (not shown) in the seed gate assembly 52 may be used to determine the seed flow rate into the seed meter 24.In some embodiments, it may be determine that clumped seeds are likely present when the seed flow rate is lower than expected.", "Additionally, the seed gate assembly 52 may be used to control the flow of seeds from the storage tank 26 into the seed meter 24.To more clearly illustrate, a perspective view of the seed meter 24 is shown in FIG.", "4.In the depicted embodiment, the seed gate assembly 52 is in a closed position.", "As such, the seed gate assembly 52 blocks the flow of seeds from the storage tank 26 into the seed meter 24.On the other hand, when the seed gate assembly 52 is in an open position, a flow path may be formed to enable seeds to flow from the storage tank 26 into the seed meter 24.In the depicted embodiment, the transition between the open and closed positions may be controlled by a lever 56.For example, the lever 56 may be moved in a clockwise direction to transition the seed gate assembly 52 from the closed position to the open position.", "Additionally, the lever 56 may be moved in a counter-clockwise direction to transition the seed gate assembly 52 from the open position to the closed position.", "Additionally, in the depicted embodiment, the seed gate assembly 52 includes multiple seed agitators 58 disposed along the longitudinal extent of the seed gate assembly 52.More specifically, each seed agitator 58 may extend perpendicularly from a surface of the gate barrier 62.In fact, in some embodiments, the seed agitators 58 may extend into the storage tank 26 as the gate barrier 62 is moved to close the seed gate assembly 52.As such, the seed gate assembly 52 may be transitioned into the closed position to facilitate dislodging clumped seeds in the storage tank 26.As described above, to further reduce the possibility of clumped seed in the storage tank 26, an umbrella seed deflector may be positioned directly above the seed gate assembly.", "To more clearly illustrate, a cross-sectional view of the seed gate assembly 52 coupled to the storage tank 26 taken along the 5-5 lines is shown in FIGS.", "5 and 6.More specifically, FIG.", "5 shows the seed gate assembly 52 in the open position and FIG.", "6 shows the seed gate assembly 52 in the closed position.", "In the depicted embodiment, the seed gate assembly 52 includes the seed agitator 58, a gate seed deflector 60, a gate barrier 62, a hinge 64, and a hinge seed deflector 66.In the depicted embodiment, the gate barrier 62 may rotate about the hinge 64 to transition the seed gate assembly 52 between the open position and the closed position.", "As depicted, when the gate barrier 62 is in the open position, a flow path 68 is formed along the gate seed deflector 60 and the gate barrier 62, which may enable seeds to flow from the storage tank 26 into the seed meter 24.Additionally, an umbrella seed deflector 70 is positioned above the flow path 68.As used herein, the term “umbrella seed deflector” is intended to describe any deflector that guides seeds away from flowing directly downward through the flow path 68 along a vertical axis, which may cause seeds to enter the flow path 68 at an angle and/or may reduce seed concentration in the flow path 68.For example, in the depicted embodiment, the umbrella seed deflector 70 is formed with two flat pieces 71 that extend longitudinally through the storage tank 26.Additionally, the two flat pieces 71 are joined to form a point 73, which faces away from the seed meter 24.In the depicted embodiment, the angle between two flat pieces 71 is approximately 90 degrees.", "However, in other embodiments, the angle may be approximately 60 degrees, 76 degrees, 105 degrees, 120 degrees, or 150 degrees.", "As such, the two flat pieces 71 may guide the seed flow around the umbrella seed deflector 70.More specifically, in the depicted embodiment, the umbrella seed deflector 70 guides seed flow through angled flow paths 72 formed along the storage tank walls 74.Thus, when the seeds flow out of the storage tank 26, the seeds are traveling in an angled direction relative to the vertical axis 75 instead of directly straight down.", "In this manner, the concentration of seeds in the flow path 68 may be reduced.", "For example, in some embodiments, a void 76 shown in FIG.", "5 may be created directly underneath the umbrella seed deflector 70.More specifically, since seeds generally flow in a downward direction (e.g., due to gravity), the umbrella seed deflector 70 may create the void 76 by blocking seed flow above the void 76.Additionally, in some embodiments, the umbrella seed deflector 70 may be used to control seed flow into the flow path 68.More specifically, the umbrella seed deflector 70 may be used so that the seed flow rate into the flow path 68 approximately equal to the seed flow rate out from the flow path 68, which may reduce the possibility of seed buildup in the flow path 68.As such, contact (e.g., contact area, number of contacts, etc.)", "between seeds while in the flow path 68 may be reduced, thereby reducing the possibility of seeds clumping together, e.g., across the seed gate assembly 52.Furthermore, the seed pressure caused by the weight of the seeds against the seed gate assembly 52 may be reduced.", "The seed flow rate into the flow path 68 may be at least partially based on the size of the angled flow paths 72 in relation to the size of the seeds.", "In the depicted embodiment, the size of the angled flow paths 72 is dependent at least on the size of the umbrella seed deflector 70.For example, when the umbrella seed deflector 70 is larger, the size of the angled flow paths 72 may be reduced, thereby reducing the seed flow rate into the flow path 68.On the other hand, when the umbrella seed deflector 70 is smaller in size, the size of the angled flow paths 72 may be increased, thereby increasing the seed flow rate into the flow path 68.In fact, in some embodiments, the umbrella seed deflector 70 may be selectively replaced, for example, to account for different seed sizes or to change the seed flow rate into the flow path 68.In addition to reducing the possibility of clumped seeds, the decreased concentration of seed in the flow path 68 may also facilitate operation of the seed gate assembly 52.More specifically, to move the gate barrier 62 toward the closed position, seeds in the path of the movement of the gate barrier 62 may be displaced.", "To help illustrate, the gate barrier 62 in the closed position is shown in FIG.", "6.As depicted, when the gate barrier 62 is in the closed position, a junction 78 is formed between the gate seed deflector 60 and the gate barrier 62, which may block the flow of seeds from the storage tank 26 into the seed meter 24.Accordingly, to move the gate barrier 62 from the open position to the closed position, seeds present in the flow path 68 may be displaced.", "More specifically, the gate barrier 62 may guide a portion of seeds in the flow path 68 into a gap behind the gate seed deflector 76 and a portion of the seeds back into the storage tank.", "The reduced concentration of seeds in the flow path 68 may improve the ease and responsiveness with which the gate barrier 62 is closed.", "More specifically, since the amount of seeds flowing through the flow path 68 is reduced by the umbrella seed deflector 70, the gate barrier 62 may displace a fewer number of seeds as it moves toward the closed position.", "Additionally, since more space is present between the seeds in the flow path 68 due to reduced seed density, the gate barrier 62 may more easily displace the seeds.", "Furthermore, the void 76 may provide addition open space in the storage tank 26 for the gate barrier 62 to displace seeds as it moves toward the closed position.", "In this manner, the ease and responsiveness with which the gate barrier 62 is closed may be improved.", "In addition to the use of the umbrella seed deflector 70, the possibility of seed clumping may further be reduced because the gate seed deflector 60, the hinge seed deflector 66, and the gate barrier 62 are oriented in a downward sloping angle relative to the vertical axis.", "As such, the seeds may flow in a laterally inward direction (e.g., through the flow path 68 and/or toward the junction 78).", "In this manner, the likelihood of seeds becoming trapped and clumping, for example along the hinge 64, may be reduced.", "Moreover, the downward sloping angles of the gate seed deflector 60, the hinge seed deflector 66, and the gate barrier 62 may facilitate opening and closing of the seed gate assembly 52.As described above, when the seed gate assembly 52 is in the closed position, the seeds may be guided toward the junction 78.In other words, the seeds may be guided toward a location at which the flow path 68 will be formed when the gate barrier is open.", "Additionally, since the junction 78 is formed at an angle, instead of as a flat surface, the possibility of seed clumping caused by the junction 78 may be reduced.", "Thus, as the seed gate assembly 52 transitions from the closed position to the open position, un-clumped (e.g., separated) seeds may begin to flow through the flow path 68.As described above, the umbrella seed deflector 70 may improve operation of the seed meter 24 (e.g., by reducing seed clumping) due to its ability to guide seeds into the flow path 68 at an angle relative to the vertical axis and to reduce seed concentration in the flow path 68.Accordingly, in some embodiments, the umbrella seed deflector 70 may be stationarily coupled to the storage tank 26 in an upright orientation.", "As used herein, the “upright orientation” is intended to describe the orientation depicted in FIGS.", "5 and 6.In other embodiments, the umbrella seed deflector 70 may be adjustable to further improve operation of the seed meter 24.For example, the size of the umbrella seed deflector 70 may be adjusted (e.g., via operator control or automatic control) to control seed flow out of the storage tank 26 into the flow path 68 and/or the size of the void 76 created.", "Additionally, in further embodiments, the umbrella seed deflector 70 may be movably coupled to the storage tank 26.To help illustrate, an embodiment of a movable umbrella seed deflector 70A is shown in FIG.", "7.As depicted, the umbrella seed deflector 70A is movably coupled to the storage tank 26 by a hinge 80, about which the umbrella seed deflector 70 may rotate.", "In some embodiments, a motor drive 82 may be coupled to the hinge 80 to actuate the umbrella seed deflector 70A as desired.", "Generally, when the umbrella seed deflector 70A rotates, seeds in the storage tank 26 may be agitated (e.g., displaced).", "Accordingly, the umbrella seed deflector 70A may be actuated to dislodge clumped seeds in the storage tank 26.In fact, the umbrella seed deflector 70A may be actuated in varying control schemes.", "For example, in some embodiments, the umbrella seed deflector 70A may be periodically actuated (e.g., every 30 seconds).", "In other embodiments, the umbrella seed deflector 70A may be continuously actuated, for example, using an electric motor and an offset linkage to oscillate the umbrella seed deflector 70A up to 30 degrees back and forth during seeding.", "In still further embodiments, the umbrella seed deflector 70A may be actuated when clumped seeds are detected.", "Additionally, since the umbrella seed deflector 70A is movable, its orientation may vary from the upright orientation, as shown in FIGS.", "5 and 6.However, as described above, the upright orientation of the umbrella seed deflector 70A may improve the ease and responsiveness with which the seed gate assembly 24 is closed.", "As such, in some control schemes, the umbrella seed deflector 70A may be positioned in its upright position as the gate barrier 62 moves toward the closed position.", "To facilitate implementing the varying control schemes, a control unit 84 may be included to control operation of the motor drive 82.For example, the control unit 84 may instruct the motor drive 82 when to actuate the umbrella seed deflector 70A, how far to rotate the umbrella seed deflector 70A, how fast to rotate the umbrella seed deflector 70A, and the like.", "Accordingly, the control unit 84 includes a processor 86 and memory 88.In some embodiments, the processor 86 may include one or more general purpose processors, one or more application specific integrated circuits, one or more field programmable gate arrays, or the like.", "Additionally, the memory 88 may be any tangible, non-transitory, computer readable medium that is capable of storing instructions executable by the processor 86 and/or data that may be processed by the processor 86.In other words, the memory 88 may include volatile memory, such as random access memory, or non-volatile memory, such as hard disk drives, read only memory, optical disks, flash memory, and the like.", "One embodiment of a process 90 that may be implemented by the control unit 84 to control the umbrella seed deflector 70A is shown in FIG.", "8.Generally, the process 90 includes detecting whether clumped seeds are present (decision block 92) and actuating the umbrella seed deflector when the clumped seeds are detected (process block 94).", "Additionally, the process 90 includes detecting whether the seed gate assembly is closing (decision block 96) and adjusting the umbrella seed deflector to the upright orientation when the seed gate assembly is closing (process block 98).", "In some embodiments, one or more steps in the process 90 may be implemented by instructions stored on a tangible, non-transitory, computer readable medium, such as the memory 88, and executable by processing circuitry, such as the processor 86.Accordingly, the control unit 84 may determine whether seed clumping is present in the storage tank 26 (decision block 92).", "In some embodiments, one or more sensors 100 may be disposed in the storage tank 26, the seed gate assembly 52, the seed meter 24, or any combination thereof, and may be communicatively coupled to the control unit 84.More specifically, the sensors 100 may be positioned to determine a flow rate of seeds flowing into the seed meter 24.Thus, the control unit 84 may determine that clumped seeds are likely present when the flow of seeds is lower than expected.", "In some embodiments, the control unit 84 may notify an operator of the flow rate with a visual display, or may notify the operator of a possibility of clumped seed with a visual or auditory indication.", "When clumped seeds are detected, the control unit 84 may instruct the motor drive 82 to actuate the umbrella seed deflector 70A (process block 94).", "More specifically, the control unit 84 may instruct the motor drive 82 when to actuate the umbrella seed deflector 70A, how far to rotate the umbrella seed deflector 70A, how fast to rotate the umbrella seed deflector 70A, and the like, to agitate the seeds in the storage tank 26.Additionally, the control unit 84 may determine when the seed gate assembly 52 is closing (decision block 96).", "In some embodiments, one or more sensors 102 may be included in the seed gate assembly 52 to detect motion of the gate barrier 62 and may be communicatively coupled to the control unit 84.Thus, when the gate barrier 62 is in the open position, the control unit 84 may determine that the seed gate assembly 52 is closing when the gate barrier 62 begins to move (e.g., toward the closed position).", "When the seed gate assembly is closing, the control unit 84 may instruct the motor drive 82 to adjust the umbrella seed deflector 70A to the upright orientation (process block 98).", "More specifically, in some embodiments, the control unit 84 may determine the difference between the current orientation of the umbrella seed deflector 70A and the upright orientation, e.g., via an angle sensor, such as a potentiometer.", "The control unit 84 may then instruct the motor drive 82 to rotate the umbrella seed deflector 70A accordingly.", "As such, the umbrella seed deflector 70A may be actuated to reduce the possibility of seed clumping as well as to improve the ease and responsiveness with which the seed gate assembly 52 may be closed.", "However, as can be appreciated, the motor drive 82 may consume energy to actuate the umbrella seed deflector 70A.", "In some embodiments, it may be possible to manually actuate the umbrella seed deflector 70A.", "For example, a lever may be directly coupled to the hinge 80 to enable an operator to manually actuate the umbrella seed deflector 70 when desired.", "In further embodiments, the actuation of the umbrella seed deflector 70 may be indirectly controlled, for example, by the umbrella seed deflector 70 to the gate barrier 62.To help illustrate, an embodiment of a movable umbrella seed deflector 70B is shown in FIG.", "9.As depicted, one edge of the umbrella seed deflector 70B is connected to the gate barrier 62 by a cable 104 (e.g., a wire or a chain).", "Thus, movement of the umbrella seed deflector 70B may be directly tied to the movement of the gate barrier 62.For example, when the gate barrier 62 is moved from the closed position to the open position, the gate barrier 62 may pull on the umbrella seed deflector 70B, causing the umbrella seed deflector 70B to actuate in a first direction (e.g., rotate counter-clockwise).", "Additionally, as depicted, the umbrella seed deflector 70B is coupled to the hinge 80 with a torsional spring 106.More specifically, as the umbrella seed deflector 70B is actuated by the opening of the gate barrier 62, rotational energy may be stored in the torsional spring 106.Thus, when the gate barrier 62 is moved to the closed position, the rotational energy stored in the torsional spring 106 may be released, thereby actuating the umbrella seed deflector 70B in an opposite direction (e.g., rotate clockwise).", "As such, the umbrella seed deflector 70B may actuate and displace seeds each time the gate barrier 62 is moved.", "In fact, this may enable the umbrella seed deflector 70B to work in unison with the seed agitator 58 on the gate barrier 62 to dislodge clumped seeds.", "For example, the gate barrier 62 may be repeatedly moved from the open position, to the closed position, and back to the open position to enable the seed agitators 58 and the umbrella seed deflector 70B to dislodge seed clumps.", "Accordingly, embodiments described herein may provide the technical benefit of improving consistency of seed distribution in a planting system.", "More specifically, an umbrella seed deflector may be included above a flow path, which extends from a seed storage tank to a seed meter that controls seed distribution.", "In some embodiments, the umbrella seed deflector may guide seeds into the flow path at an angle relative to a vertical axis to reduce the concentration of seeds in the flow path, which may improve the ease and responsiveness with which a seed gate assembly may be closed and/or which may reduce the possibility of the flow path being obstructed by clumped seeds.", "Additionally, in some embodiments, the umbrella seed deflector may be actuated to agitate (e.g., displace) seeds, thereby further reducing the possibility of seeds clumping.", "While only certain features of the invention have been illustrated and described herein, many modifications and changes will occur to those skilled in the art.", "It is, therefore, to be understood that the appended claims are intended to cover all such modifications and changes as fall within the true spirit of the invention." ] ]
Patent_15874104
[ [ "Headphone Joint", "A headphone with a headband and at least one earcup.", "The at least one earcup is movably coupled to the headband by a joint that is structured to allow rotation of the earcup relative to the headband about two mutually perpendicular axes, and translation along one of these axes." ], [ "1.A headphone, comprising: a headband; an earcup; and a joint that is constructed and arranged to movably couple the earcup to the headband, wherein the joint is structured to allow motions of the earcup relative to the headband, the motions comprising rotations of the earcup relative to the headband about two mutually perpendicular axes and translation of the earcup relative to the headband along one of these axes; wherein the joint comprises a projection on one of the headband and the earcup, and a slot in the other of the headband and earcup, where the projection is at least in part received by the slot; wherein the projection comprises a stem, and an enlarged rounded portion coupled to the stem and frictionally engaged in the slot so as to constrain at least one of the motions of the earcup relative to the headband.", "2.The headphone of claim 1, wherein the enlarged rounded portion comprises a friction element.", "3.The headphone of claim 2, wherein the friction element defines part of an outer surface of the enlarged rounded portion.", "4.The headphone of claim 3, wherein the friction element comprises an o-ring.", "5.The headphone of claim 3, wherein the friction element is compressed against an inner wall of the slot.", "6.The headphone of claim 2, wherein the friction element is constructed and arranged to provide forces that resist translation of the earcup relative to the headband along a first axis, and rotation of the earcup relative to the headband about the first axis.", "7.The headphone of claim 1, wherein the enlarged rounded portion comprises a generally cylindrical member.", "8.The headphone of claim 1, wherein the enlarged rounded portion comprises a generally spherical body.", "9.The headphone of claim 1, wherein the stem is coupled to the earcup such that the stem is adapted to pivot relative to the earcup.", "10.The headphone of claim 9, wherein the stem is coupled to the earcup by a pin.", "11.The headphone of claim 1, wherein the enlarged rounded portion and the slot both have a diameter, and wherein the frictional engagement of the enlarged rounded portion in the slot is accomplished by the diameter of the slot being less than the diameter of the enlarged rounded portion.", "12.The headphone of claim 1, wherein the slot is in a slider that is part of the headband.", "13.The headphone of claim 12, wherein the slider is curved.", "14.The headphone of claim 12, wherein the slider sits in a recess in the earcup.", "15.The headphone of claim 14, wherein the recess has sidewalls that are proximate to the slider, such that the recess sidewalls inhibit translational motion of the slider along one of the mutually perpendicular axes.", "16.The headphone of claim 14, wherein the recess comprises first and second surfaces that slope away from the projection.", "17.The headphone of claim 16, wherein the slider has a lower side that is arranged to contact the first and second sloped surfaces, to define end points of rotation of the slider about an axis.", "18.The headphone of claim 12, wherein the joint is structured such that rotation about one axis is constrained by the stem.", "19.The headphone of claim 18, wherein the stem passes through the slot, and the slot is wider than the stem and comprises end walls proximate the stem, wherein the stem can rotate relative to the slider, and end points of this rotation are established when either end wall contacts the stem.", "20.The headphone of claim 1, wherein the projection is on the earcup and the slot is in the headband." ], [ "<SOH> BACKGROUND <EOH>This disclosure relates to a headphone.", "Headphones have one or two earcups.", "In order to be adjustable so as to comfortably fit most heads, the earcups should be able to rotate about the vertical axis and at least one axis that is orthogonal to the vertical axis.", "The earcups should also be able to translate along the vertical axis.", "Many headphones use yokes to couple the earcups to the headband to help accomplish the necessary rotations, but yokes are relatively large and are not integral to the headband design.", "There is a need for an earcup-to-headband joint that provides for rotation about two axes and translation along one axis, while being better integrated into the headband design." ], [ "<SOH> SUMMARY <EOH>A headphone joint that is structured to allow rotation of each earcup relative to the headband about two mutually perpendicular axes, and translation along one of these axes.", "The joint can be integral to the part of the headband and the part of the earcup that interface.", "There is thus no outward evidence of the joint, unlike the case with headphones that use yokes to rotatably connect the headband to the earcups.", "All examples and features mentioned below can be combined in any technically possible way.", "In one aspect, a headphone includes a headband and at least one earcup.", "The at least one earcup is movably coupled to the headband by a joint that is structured to allow rotation of the earcup relative to the headband about two mutually perpendicular axes, and translation along one of these axes.", "Embodiments may include one of the following features, or any combination thereof.", "The joint may comprise a projection on one of the headband and earcup and a slot in the other of the headband and earcup, where the projection is at least in part received by the slot.", "In one non-limiting example, the projection is on the earcup.", "The projection may comprise a generally partially spherical surface.", "The projection may further comprise a generally conical surface with an apex.", "The apex may be rounded.", "In one case the apex is generally spherical.", "The centers of the rounded apex and the generally partially spherical surface of the projection may be essentially coincident.", "The projection may comprise a stem with a distal end, where the generally conical surface is located at the distal end, and there is a generally partially spherical surface that is adjacent to the generally conical surface.", "The one of the headband and earcup that includes the projection may further comprise first and second surfaces, each of which slopes away from the projection.", "Embodiments may include one of the following features, or any combination thereof.", "The slot may in part be defined by a first surface that is in contact with the apex.", "The slot may in part be further defined by second and third surfaces that are adjacent to or in contact with the generally partially spherical surface of the projection.", "These second and third surfaces may be generally flat, and they may be generally tangent to the generally partially spherical surface of the projection.", "The slot may have an opening, and an enlarged area adjacent to the opening.", "The enlarged area may in part be defined by sidewalls that generally follow arcs of a circle, where the center of the circle is generally coincident with the center of the generally partially spherical surface.", "The slot opening may be narrower than the diameter of the generally partially spherical surface of the projection.", "The joint may be structured such that rotation about one axis is constrained by the projection.", "Rotation about the other axis may be constrained by the sloped first and second surfaces of the one of the headband and earcup that includes the projection.", "Embodiments may include one of the following features, or any combination thereof.", "The headphone may further comprise a detent structure that defines a plurality of relative translational positions of the earcup and the headband.", "The detent structure may comprise at least one spring on one of the headband and earcup, and a series of spring-receiving notches on the other of the headband and earcup.", "In another aspect, a headphone includes a headband and at least one earcup.", "The at least one earcup is movably coupled to the headband by a joint that is structured to allow rotation of the earcup relative to the headband about two mutually perpendicular axes, and translation along one of these axes.", "The joint comprises a projection on the earcup and a slot in the headband, wherein the projection is at least in part received by the slot and comprises a stem with a distal end, a generally conical surface with an apex located at the distal end, and a generally partially spherical surface adjacent to the generally conical surface.", "The earcup further comprises first and second surfaces, each of which slopes away from the projection.", "The slot has an opening, and an enlarged area adjacent to the opening.", "The slot opening is narrower than the diameter of the generally partially spherical surface of the projection.", "The slot is in part defined by a first surface that is in contact with the apex and second and third surfaces that are adjacent to or in contact with the generally partially spherical surface of the projection.", "Embodiments may include one of the following features, or any combination thereof.", "The generally conical surface may have a rounded apex.", "The centers of the rounded apex and the generally partially spherical surface of the projection may be essentially coincident.", "The second and third surfaces that in part define the slot may be generally flat and generally tangent to the generally partially spherical surface of the projection.", "In another aspect, a headphone includes a headband and at least one earcup.", "The at least one earcup is movably coupled to the headband by a joint that is structured to allow rotation of the earcup relative to the headband about two mutually perpendicular axes, and translation along one of these axes.", "The joint comprises a projection on the earcup and a slot in the headband.", "The projection is at least in part received by the slot and comprises a stem with a distal end, a generally conical surface with a generally spherical apex located at the distal end, and a generally partially spherical surface adjacent to the generally conical surface, wherein the centers of the generally spherical apex and the generally partially spherical surface of the projection are essentially coincident.", "The slot has an opening that is narrower than the diameter of the generally partially spherical surface of the projection, and an enlarged area adjacent to the opening.", "The enlarged area is in part defined by sidewalls that generally follow arcs of a circle, where the center of the circle is generally coincident with the center of the generally partially spherical surface of the projection.", "Embodiments may include one of the following features, or any combination thereof.", "The earcup may comprise first and second surfaces, each of which slopes away from the projection.", "The joint may be structured such that rotation about one axis is constrained by the projection, and rotation about the other axis is constrained by the first and second surfaces of the earcup.", "The slot may in part be defined by a first flat surface that is in contact with the apex." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation of and claims priority to application Ser.", "No.", "15/063,419, filed on Mar.", "7, 2016.BACKGROUND This disclosure relates to a headphone.", "Headphones have one or two earcups.", "In order to be adjustable so as to comfortably fit most heads, the earcups should be able to rotate about the vertical axis and at least one axis that is orthogonal to the vertical axis.", "The earcups should also be able to translate along the vertical axis.", "Many headphones use yokes to couple the earcups to the headband to help accomplish the necessary rotations, but yokes are relatively large and are not integral to the headband design.", "There is a need for an earcup-to-headband joint that provides for rotation about two axes and translation along one axis, while being better integrated into the headband design.", "SUMMARY A headphone joint that is structured to allow rotation of each earcup relative to the headband about two mutually perpendicular axes, and translation along one of these axes.", "The joint can be integral to the part of the headband and the part of the earcup that interface.", "There is thus no outward evidence of the joint, unlike the case with headphones that use yokes to rotatably connect the headband to the earcups.", "All examples and features mentioned below can be combined in any technically possible way.", "In one aspect, a headphone includes a headband and at least one earcup.", "The at least one earcup is movably coupled to the headband by a joint that is structured to allow rotation of the earcup relative to the headband about two mutually perpendicular axes, and translation along one of these axes.", "Embodiments may include one of the following features, or any combination thereof.", "The joint may comprise a projection on one of the headband and earcup and a slot in the other of the headband and earcup, where the projection is at least in part received by the slot.", "In one non-limiting example, the projection is on the earcup.", "The projection may comprise a generally partially spherical surface.", "The projection may further comprise a generally conical surface with an apex.", "The apex may be rounded.", "In one case the apex is generally spherical.", "The centers of the rounded apex and the generally partially spherical surface of the projection may be essentially coincident.", "The projection may comprise a stem with a distal end, where the generally conical surface is located at the distal end, and there is a generally partially spherical surface that is adjacent to the generally conical surface.", "The one of the headband and earcup that includes the projection may further comprise first and second surfaces, each of which slopes away from the projection.", "Embodiments may include one of the following features, or any combination thereof.", "The slot may in part be defined by a first surface that is in contact with the apex.", "The slot may in part be further defined by second and third surfaces that are adjacent to or in contact with the generally partially spherical surface of the projection.", "These second and third surfaces may be generally flat, and they may be generally tangent to the generally partially spherical surface of the projection.", "The slot may have an opening, and an enlarged area adjacent to the opening.", "The enlarged area may in part be defined by sidewalls that generally follow arcs of a circle, where the center of the circle is generally coincident with the center of the generally partially spherical surface.", "The slot opening may be narrower than the diameter of the generally partially spherical surface of the projection.", "The joint may be structured such that rotation about one axis is constrained by the projection.", "Rotation about the other axis may be constrained by the sloped first and second surfaces of the one of the headband and earcup that includes the projection.", "Embodiments may include one of the following features, or any combination thereof.", "The headphone may further comprise a detent structure that defines a plurality of relative translational positions of the earcup and the headband.", "The detent structure may comprise at least one spring on one of the headband and earcup, and a series of spring-receiving notches on the other of the headband and earcup.", "In another aspect, a headphone includes a headband and at least one earcup.", "The at least one earcup is movably coupled to the headband by a joint that is structured to allow rotation of the earcup relative to the headband about two mutually perpendicular axes, and translation along one of these axes.", "The joint comprises a projection on the earcup and a slot in the headband, wherein the projection is at least in part received by the slot and comprises a stem with a distal end, a generally conical surface with an apex located at the distal end, and a generally partially spherical surface adjacent to the generally conical surface.", "The earcup further comprises first and second surfaces, each of which slopes away from the projection.", "The slot has an opening, and an enlarged area adjacent to the opening.", "The slot opening is narrower than the diameter of the generally partially spherical surface of the projection.", "The slot is in part defined by a first surface that is in contact with the apex and second and third surfaces that are adjacent to or in contact with the generally partially spherical surface of the projection.", "Embodiments may include one of the following features, or any combination thereof.", "The generally conical surface may have a rounded apex.", "The centers of the rounded apex and the generally partially spherical surface of the projection may be essentially coincident.", "The second and third surfaces that in part define the slot may be generally flat and generally tangent to the generally partially spherical surface of the projection.", "In another aspect, a headphone includes a headband and at least one earcup.", "The at least one earcup is movably coupled to the headband by a joint that is structured to allow rotation of the earcup relative to the headband about two mutually perpendicular axes, and translation along one of these axes.", "The joint comprises a projection on the earcup and a slot in the headband.", "The projection is at least in part received by the slot and comprises a stem with a distal end, a generally conical surface with a generally spherical apex located at the distal end, and a generally partially spherical surface adjacent to the generally conical surface, wherein the centers of the generally spherical apex and the generally partially spherical surface of the projection are essentially coincident.", "The slot has an opening that is narrower than the diameter of the generally partially spherical surface of the projection, and an enlarged area adjacent to the opening.", "The enlarged area is in part defined by sidewalls that generally follow arcs of a circle, where the center of the circle is generally coincident with the center of the generally partially spherical surface of the projection.", "Embodiments may include one of the following features, or any combination thereof.", "The earcup may comprise first and second surfaces, each of which slopes away from the projection.", "The joint may be structured such that rotation about one axis is constrained by the projection, and rotation about the other axis is constrained by the first and second surfaces of the earcup.", "The slot may in part be defined by a first flat surface that is in contact with the apex.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a front view of a headphone.", "FIG.", "2 shows one earcup and a part of the headband that interfaces with the earcup and makes up part of the earcup-to-headband joint herein.", "FIG.", "3 is a perspective view of portions of the earcup and headband involved in the subject joint.", "FIG.", "4 is a perspective view of the portion of the earcup involved in the subject joint.", "FIG.", "5 is a perspective view of the portion of the headband involved in the subject joint.", "FIG.", "6A is a cross-sectional view taken along line 6A-6A of FIG.", "3, illustrating the subject joint in the neutral position.", "FIG.", "6B is a view similar to that of FIG.", "6A but illustrates rotation about the x axis.", "FIG.", "6C is a view similar to that of FIG.", "6A but illustrates a slightly different example of the joint.", "FIG.", "7A is a cross-sectional view taken along line 7A-7A of FIG.", "3, illustrating the subject joint in the neutral position.", "FIG.", "7B is a view similar to that of FIG.", "7A but illustrates rotation about the z axis.", "FIG.", "8 is a partial perspective view of another headphone joint.", "FIG.", "9 is a perspective view of the earcup of the joint of FIG.", "8.FIG.", "10 is a perspective view of the slider of the joint of FIG.", "8.FIG.", "11A is a cross-sectional view taken along line 11-11 of FIG.", "8, showing the joint in the neutral position.", "FIG.", "11B is a view similar to that of FIG.", "11A, but showing the joint in a rotated position.", "FIG.", "12A is a cross-sectional view taken along line 12-12 of FIG.", "8, showing the joint in the neutral position.", "FIG.", "12B is a view similar to that of FIG.", "12A, but showing the joint in a rotated position.", "FIG.", "13 illustrates an alternative projection to that shown in FIGS.", "9 and 10.FIGS.", "14A and 14B are side and top views, respectively, of another projection.", "FIGS.", "15A and 15B are side and top views, respectively, of a slider that can be used with the projection of FIGS.", "14A and 14B.", "DETAILED DESCRIPTION A headphone refers to a device that fits around, on, or in an ear and that radiates acoustic energy into the ear canal.", "Headphones are sometimes referred to as earphones, earpieces, headsets, earbuds or sport headphones, and can be wired or wireless.", "A headphone includes an acoustic driver to transduce audio signals to acoustic energy.", "The acoustic driver may be housed in an earcup.", "While some of the figures and descriptions following show a single headphone, a headphone may be a single stand-alone unit or one of a pair of headphones (each including a respective acoustic driver and earcup), one for each ear.", "A headphone may be connected mechanically to another headphone, for example by a headband and/or by leads that conduct audio signals to an acoustic driver in the headphone.", "A headphone may include components for wirelessly receiving audio signals.", "A headphone may include components of an active noise reduction (ANR) system.", "Headphones may also include other functionality such as a microphone so that they can function as a headset.", "In an around or on the ear headphone, the headphone may include a headband and at least one earcup that is arranged to sit on or over an ear of the user.", "In order to accommodate heads of different sizes and shapes, the earcups need to be able to pivot about the vertical and horizontal axes, and they need to translate for some distance along the vertical axis.", "The headband can be collapsible or foldable, and can be made of multiple parts.", "Some headbands include sliders, which may be positioned internal to the headband, that provide for the necessary translation of the earcups.", "Some headphones include a yoke pivotally mounted to the headband, with the earcups pivotally mounted to the yoke, to provide for the necessary rotation of the earcups.", "The headphones of the present disclosure have a joint that couples the earcup to the headband and is structured to allow constrained rotation of the earcups relative to the headband about two mutually perpendicular axes, as well as constrained translation along one of these axes.", "Thus, the joint described herein enables the necessary rotation and translation to accommodate heads of different sizes and shapes.", "Headphone 10, FIG.", "1, includes headband 12 with head cushion 13, and earcup 14 with ear cushion 15.The headphone can alternatively include two earcups, each of which is arranged as described herein.", "Headband 12 is designed to fit on and over a user's head, and can be constructed in different manners as are known in the art.", "For example, the headband can be collapsible or foldable, and can be made of multiple parts.", "Some headbands also include sliders, which may be positioned internal to the headband, that allow the earcups to be slid in and out relative to a fixed part of the headband.", "Joint 20 movably couples earcup 14 to headband 12 so as to provide for constrained rotation of the earcup about vertical axis x and constrained rotation about the orthogonal horizontal axis z (which is directed in and out of the page in FIG.", "1).", "Joint 20 also provides for constrained translation along the vertical axis x.", "An exemplary earcup 14 is shown in FIG.", "2, along with portion 30 of an exemplary headband 12 that is involved in the construction of joint 20.Note that portion 30 may be a separate piece as shown in FIG.", "2 but can also be integral to headband 12, or integral to a portion of headband 12.Portion 30 is depicted apart from the headband simply for ease of illustration of the subject joint.", "As shown in FIG.", "2, earcup 14 includes a portion 40 that is also involved in the construction of joint 20.Portion 40 may be, for example, a slot, recess or other feature for receiving portion 30 of the headband 12.The earcup 14 may be a different shape and/or size from the exemplary earcup shown in FIG.", "2.The following figures illustrate the joint 20 further.", "Portion 40 of earcup 14 that is involved in the construction of joint 20 is shown in FIG.", "3, without the rest of the earcup 14.As in FIG.", "2, while the components of FIG.", "3 are illustrated as being separate pieces or parts, they can also be integral parts of the headband and/or earcup.", "As in FIG.", "2, portion 40 of earcup 14 includes a slot, recess or other feature for receiving portion 30 of the headband 12.Portion 30 of headband 12 also includes a slot 50 that is configured to enable portion 30 to rotate in two mutually two mutually perpendicular axes, and translate along one of these axes, as described herein.", "Earcup portion 40 is shown alone in FIG.", "4.As shown, earcup portion 40 includes a projection 60 that is centered between sloped surfaces 41 and 42 that slope away from projection 60 in both directions along the x axis.", "Projection 60 may include stem 62 (which can take a variety of shapes and sizes) topped by a generally partially spherical surface 64 that transitions to a generally conical surface 66.The stem 62, generally partially spherical surface 64 and generally conical surface 66 may be formed integrally or may be separate pieces.", "The generally conical surface 66 includes an apex 68 at the distal end of projection 60.Also shown is detent spring 70 with detent projection 72.All of these aspects of joint 20 are further described below.", "Headband portion 30 is shown alone in FIG.", "5.As shown, slot 50 has an opening 52 that is adjacent to enlarged area 54.As will be described herein, slot 50, opening 52 and enlarged area 54 cooperate with projection 60 of the earcup portion 40 (FIG.", "4).", "Headband portion 30 also includes a lower side 53 that is further described below.", "A series of detent notches 56 cooperate with detent spring 70 and detent projection 72 of earcup portion 40 (FIG.", "4).", "As with FIG.", "4, the aspects of joint 20 shown in FIG.", "5 are further described below.", "FIG.", "6A is a cross-sectional view of the earcup-to-headband joint taken along line 6A-6A of FIG.", "3, illustrating joint 20 in the neutral position.", "Projection 60 is received in slot 50, which is partially defined by first generally flat surface 31 and second and third generally flat surfaces 32 and 33.Projection 60 has a generally partially spherical surface 64 that has a diameter that is larger than slot opening 52 so that projection 60 remains in slot 50.Surface 64 defines a generally spherical contour, at least on its opposed sides that contact or are very close to flat sides 32 and 33 that define part of slot 50.The rest of surface 64 does not need to be spherical or generally spherical.", "Sides 32 and 33 may be generally tangent to surface 64, although sides 32 and 33 do not necessarily actually contact surface 64.Sides 32 and 33 (which need not be flat but could be curved) may also be looked at as generally following arcs of a circle on which surface 64 lies, where the center of the circle is generally coincident with the center of the generally partially spherical surface 64.Projection 60 further comprises generally conical top (end) surface 66 that has apex 68.Apex 68 may or may not be rounded.", "Stem 62 of projection 60 is received by slot opening 52.In the neutral position shown in FIG.", "6A, surface 31 contacts apex 68 but does not contact generally conical top surface 66.While surface 66 does not need to be conical, it should define surfaces on either side of the x axis (shown in FIG.", "6A as being in and out of the page) that serve as support positions for the headband as relative rotation of the earcup and headband occur.", "Surface 66 thus acts to support portion 30 (and thus the headband) to inhibit it from rocking on apex 68 upon relative rotation of the earcup and/or the headband about the x axis.", "Also shown is detent spring 70 with projection 72 that cooperates with detent notch 57 (a second detent spring/projection and notch may also be included on the other side of portion 30).", "Portion 30 can be slid along the x axis in both directions.", "The series of detent notches 56 (which are preferably but not necessarily on both sides of portion 30) define a series of spaced stop positions for the relative translational motions of portions 30 and 40.In operation, when portion 30 is slid along the x axis, it will move freely until it engages a stop position defined by detent notches 56, thus enabling a user to customize the length of the headband 12 to accommodate a variety of head shapes and sizes.", "While a detent mechanism is shown in FIG.", "6A to provide the spaced stop positions, other mechanisms could be used, including friction or a different type of mechanical feature on each portion 30 and 40 that engage with each other.", "FIG.", "6B is a view similar to that of FIG.", "6A but illustrates full rotation in one direction about the x axis, where surface 31 contacts surface 66.As shown in FIG.", "6B, end surfaces 34 and 35 of portion 30 are preferably constructed and arranged such that their contact with stem 62 is actually what defines the rotation end or stop positions.", "Accordingly, when end surface 34 contacts stem 62, further rotation about the x axis in that direction is prohibited.", "The angle of conical surface 66 from a horizontal line is selected such that the desired full angle of rotation is supported.", "In non-limiting examples, this angle is between about 10 degrees and about 25 degrees so as to accommodate heads of different size and shape.", "End surfaces 34 and 35 along with stem 62 thus enable constrained rotation of the earcup 14 about the x axis.", "In other examples, surface 66 could be constructed and arranged to define the rotation end or stop positions.", "Rotation in the other direction would be handled in the same way.", "The angle of surface 66 (in both directions) and the locations of ends 34 and 35 (via, e.g., the diameter of stem 62) are selected to achieve a desired angular rotation about the x axis; in the present non-limiting example this rotation is about 10 degrees in either direction about the x axis.", "FIG.", "6C is a view similar to that of FIG.", "6A but illustrates a slightly different example of the joint, where apex 68a is rounded, e.g., generally partially spherical.", "The centers of the rounded apex 68a and the generally partially spherical surface 64 may be essentially coincident at center 69.This both ensures and constrains the purely rotational motion about center 69.Rounded apex 68a provides more support for surface 31 as rotation about the x axis occurs when compared to examples where apex is not rounded.", "Also seen in more detail in FIG.", "6C are generally tangent surfaces 32 and 33, which are located close to or touching surface 64.Surfaces 32 and 33 remain generally tangent to surface 64 as rotation about the x axis occurs.", "Surfaces 32 and 33 thus inhibit side-to-side sliding motion of surface 31 on apex 68a, and so further constrain relative motions of the earcup and headband to rotations about the x and z axes, and translation along the x axis.", "Translation along the z axis is also inhibited because portion 30 sits in the slot in portion 40.Rotations about the z axis are depicted in FIGS.", "7A and 7B (where the z axis is into and out of the page of the drawing).", "The neutral position is shown in FIG.", "7A, where surface 31 of headband portion 30 sits on apex 68.Portions 30 and 40 are free to relatively rotate about the z axis until lower side 53 of portion 30 contacts one of sloped surfaces 41 and 42 (contact is not shown in FIG.", "7B simply for the sake of clarity).", "Contact of these two surfaces preferably defines the rotation end ranges, which in this non-limiting example are about 10 degrees in either direction about the z axis, but could be more or less than 10 degrees.", "The angle at which the sloped surfaces 41 and 42 slope is thus selected to achieve a desired angular rotation about the z axis.", "In other examples, surface 66 could be constructed and arranged to define the rotation end or stop positions about the z axis.", "One of many possible alternative joints is depicted in FIGS.", "8-12.Joint 90 movably couples earcup 92 to headband slider 94 so as to provide for constrained rotation of the earcup about the vertical axis (which is parallel to line 11-11, FIG.", "8), and constrained rotation about the orthogonal horizontal axis (which is parallel to line 12-12).", "Joint 90 also provides for constrained translation along the vertical axis via slider 94, which can translate relative to earcup 92 within earcup slot 96 along the vertical axis.", "Earcup projection 98 of joint 90 is shown in FIGS.", "9-12.Projection 98 includes stem 110 that is pivotally coupled to earcup 92 via pin 128 that passes through hole 154, so as to allow relative rotation about the z axis (see FIG.", "11A).", "Generally cylindrical member 100 is carried at the distal end of stem 110.Member 100 has tapered, rounded ends 108 and 106, but the ends need not be rounded.", "Member 100 carries o-rings 102 and 104, which may have but need not have rectangular cross-sectional shapes to inhibit them from rolling in their grooves.", "Rounding ends 108 and 106 eases assembly of the o-rings and avoids sharp corners that might catch on the tube wall.", "Stem 110 and member 100 may be but need not be integrally molded along with earcup 92.Headband slider 94 of joint 90 is shown in FIGS.", "10-12.Slider 94 is part of the headphone headband, which is not further shown in FIGS.", "8-12, simply for ease of illustration.", "Slider 94 may be but need not be integrally molded with the headphone headband.", "Slider 94 comprises tube 120 with closed end 121 and elongated longitudinal slot 122 through which stem 110 projects.", "Tube 120 thus is supported by and rides on projection 98.Slot 122 includes enlarged portion 124 that allows member 100 to be fitted into tube 120 in order to facilitate assembly of the headphones.", "Portion 124 could be closed or narrowed after assembly in order to prevent decoupling.", "Other constructions could prevent de-coupling of member 100 and tube 120.Several non-limiting constructions include a stop member that plugs aperture 124; this could be a separate plug or an end of a headband spring that slides into the tube and is locked in place.", "Another option would be to extend slot 122 through one end of tube 120 to allow for insertion of member 100 into tube 120, and then closing the open end of the tube, for example with end 121.Another option would be to make stem 110 and member 100 separate pieces that were coupled together in place so that member 100 could be inserted from one end of the tube.", "Stem 110 is slightly narrower than the width of slot 122 so that tube 120 and stem 110 (and thus earcup 92) can relatively rotate about the z axis, up to an angular extent at which stem 110 contacts one of the sidewalls the define slot 122.This rotation is further shown and described below relative to FIGS.", "12A and 12B.", "Joint 90 is depicted in its neutral position in FIGS.", "11A and 12A, wherein slider 94 is approximately centered in its travel along the x axis, and is rotationally centered about the x and z axes.", "Stem 110 of projection 98 fits into slot 126 in earcup 92.O-rings 102 and 104 accomplish a frictional engagement between generally cylindrical member 100 and the interior of tube 120.The friction should be sufficient to hold the earcup in place but allow it to be translated up and down by the user.", "Frictional engagement could be accomplished in other manners, without o-rings.", "For example, member 100 could have a diameter slightly greater than the interior diameter of tube 120 so that the two are held in place.", "Tube 120 could have enough flexibility to allow the holding force to be overcome by the user.", "Rotation about the z axis is constrained (stopped) when lower wall 134 of tube 120 contacts either sloped wall 130 or sloped wall 132 of earcup 92.In one non-limiting example, the rotations that can be accommodated are about +/−10 degrees from the neutral position.", "See FIG.", "11B which illustrates one stop position wherein wall 134 has contacted wall 130.Constrained rotation about the x axis is depicted in FIG.", "12A and 12B.", "Tube 120 defines an interior cavity 142 in which member 100 is located.", "Cavity 142 may be defined by top wall 140 and angled sidewalls 144 and 146.Top wall 140 need not be flat.", "O-ring 102 is large enough to create an interference fit with cavity 142; in this non-limiting illustrative example this is accomplished with the three flat walls 140, 144 and 146 that thereby accomplish a three-point interference fit with member 100.The three points can be but need not be at about 120 degree intervals around the circumference of member 100.A three-point fit is not required but does help to balance the forces needed to rotate about and translate along the x axis.", "The rotational end points are established when either of end walls 148 and 150 contacts stem 110.One such end point is illustrated in FIG.", "12B, wherein end wall 150 has contacted stem 110.Note that the tube shape shown is not necessary to the interference fit, as many other shapes are possible.", "One of many possible alternative earcup projection designs is depicted in FIG.", "13.Projection 160 includes stem 163 that is an integral part of center section 162.End sections 164 and 166, which carry o-rings 165 and 167, respectively, are adapted to rotate about the x axis relative to section 162 (e.g., by using bearing surfaces where section 162 meets sections 164 and 166).", "This construction allows rotation about the z axis to occur without the o-rings moving relative to the headband, which provides for easier pivoting about the z axis as compared to that of projection 98.Two additional alternatives for the subject joint are depicted in FIGS.", "14 and 15.Projection 180 includes a generally spherical body 182 carried on the end of stem 184, which would be coupled to or integral with the earcup (not shown).", "Generally spherical body 182 is part of a ball joint 170 once body 182 is captured in tube 172, FIG.", "15.As with joint 90, rotation about the x axis is constrained by stem 184 being slightly narrower than the width of slot 174 in tube 172 such that the stem contacts the slot side walls to establish the rotational end points as the earcup and headband pivot about the x axis.", "The relative widths are selected to achieve a desired rotational range.", "Rotation about the z axis is provided by the relative rotation of sphere 182 within the cylindrical central longitudinal opening 175 of tube 172.Desired frictional engagement (to hold the joint in place) can be accomplished by making the diameter of opening 175 about 0.95 times the diameter of sphere 182, and providing sufficient flexibility to tube 172 (e.g., by making the tube of spring steel or another flexible material).", "FIG.", "15A also depicts another alternative that can be applied to the joints disclosed herein, where tube 172 is curved along the x axis rather than straight as in the other examples.", "A curved tube will sit closer to the head and so may be a preferred industrial design.", "In order to accommodate rotation of a curved tube about the x axis, slot 96 in earcup 92 (see FIG.", "9 for example) would need to be shaped differently.", "For example, the ends of the slot could be wider than the middle (similar to the shape of butterfly wings) so that the tube does not contact the sides of earcup slot 96 as this rotation occurs.", "The joint disclosed herein can be used in other applications where constrained rotations about two orthogonal axes, with constrained translation along one of these axes, is needed.", "One non-limiting example includes a boom microphone, where the microphone needed to be rotatable in two axes and translatable along one of these axes.", "A number of implementations have been described.", "Nevertheless, it will be understood that additional modifications may be made without departing from the scope of the inventive concepts described herein, and, accordingly, other embodiments are within the scope of the following claims." ] ]
Patent_15874108
[ [ "CONTROL LINES TO SENSING COMPONENTS", "Examples of the present disclosure provide apparatuses and methods related to performing a loop structure for operations performed in memory.", "An example apparatus might include an array of memory cells.", "An example apparatus might also include a plurality of sensing components coupled to the array and comprising a first group of sensing components coupled to a controller via a first number of control lines and a second group of sensing components coupled to the controller via a second number of control lines wherein the controller is configured to activate at least one of the first number of control lines and the second number of control lines." ], [ "1.An apparatus, comprising: an array of memory cells; a controller coupled to the array; a first group of first sensing components coupled to the controller by a first number of control lines; a second group of second sensing components coupled to the controller by a second number of control lines; wherein the controller is configured to selectively equilibrate first sense amplifiers of the first sensing components while the first sense amplifiers are not activated, while second sense amplifiers of the second sensing components are not equilibrated, and while the second sense amplifiers are activated; wherein the first sensing components are configured to transfer data from first compute components of the first sensing components to the first sense amplifiers while the first sense amplifiers are equilibrated and not activated; and wherein the second sensing components are configured to transfer data from the second sense amplifiers to second compute components of the second sensing components while the second sense amplifiers are activated and not equilibrated.", "2.The apparatus of claim 1, wherein: the first sensing components are configured to transfer the data from the first compute components to the first sense amplifiers in response to the controller activating first logical operation selection logic components of the first sensing components; and the second sensing components are configured to transfer the data from the second sense amplifiers to the second compute components in response to the controller activating second logical operation selection logic components of the second sensing components while the first logical operation selection logic components are activated.", "3.The apparatus of claim 1, wherein the first sensing components are configured to transfer the data from the first compute components to the first sense amplifiers without data stored in the second compute components being updated.", "4.The apparatus of claim 1, wherein the data transferred from the second sense amplifiers to the second compute components is first data, wherein the controller is configured to, before the first data is transferred the second compute components, activate the second sense amplifiers to transfer the first data from memory cells of the array to the second sense amplifiers.", "5.The apparatus of claim 1, wherein the selective equilibration of the respective first sense amplifiers by the controller removes data from the first sense amplifiers.", "6.The apparatus of claim 1, wherein the controller being configured to selectively equilibrate the first sense amplifiers comprises the controller being configured to selectively short pairs of data lines coupled to the first sense amplifiers.", "7.The apparatus of claim 1, wherein controller is configured to charge pairs of data lines coupled to the first sense amplifiers and pairs of data lines coupled to the second sense amplifiers while the first sense amplifiers and the second sense amplifiers are equilibrated.", "8.The apparatus of claim 1, wherein the first sensing components are configured to transfer the data from the first compute components to the first sense amplifiers without modifying data stored in the first compute components.", "9.The apparatus of claim 1, wherein the controller is configured to: select an access line coupled to a first group of memory cells of the array coupled to the first group of first sensing components and a second group of memory cells of the array coupled to the second group of first sensing components; and to activate the first sense amplifiers and the second sense amplifiers concurrently while the access line is selected and while the first sense amplifiers and the second sense amplifier are not equilibrated to move data from the first group of memory cells to the first sense amplifiers and to move data from the second group of memory cells to the second sense amplifiers concurrently.", "10.The apparatus of claim 9, wherein: the controller being configured to selectively equilibrate the first sense amplifiers comprises the controller being configured to selectively remove the data from the first sense amplifiers by selectively equilibrating first sense amplifiers, the controller is configured to retain the data moved to the second sense amplifiers by not equilibrating the sense amplifiers; and the retained data is the data that is transferred from the second sense amplifiers to second compute components.", "11.A method, comprising: moving first data from first memory cells to first sense amplifiers of first sensing components of a group of the first sensing components and moving second data from second memory cells to second sense amplifiers of second sensing components of a group of the second sensing components concurrently, wherein the group of the first sensing components and group second of the second sensing components are coupled to different control lines; removing the first data from the first sense amplifiers by equilibrating the first sense amplifiers; transferring third data in first compute components of the first sensing components to the first sense amplifiers while the first sense amplifiers are equilibrated; and transferring the second data from the second sense amplifiers to second compute components of the second sensing components while the second sense amplifiers are not equilibrated and while transferring the third data in the first compute components to the first sense amplifiers.", "12.The method of claim 11, wherein transferring the third data in the first compute components to the first sense amplifiers occurs without modifying the third data in the first compute components.", "13.The method of claim 11, wherein transferring the second data from the second sense amplifiers to the second compute components occurs without updating the third data in the first compute components.", "14.The method of claim 11, wherein: transferring the third data to the first sense amplifiers occurs while the first sense amplifiers are deactivated and while logical operation selection logic components of the first sensing components are activated; and transferring the second data from the second sense amplifiers to the second compute components occurs while the second sense amplifiers are activated and while logical operation selection logic components of the second sensing components are activated.", "15.The method of claim 11, wherein moving the first data from first memory cells to the first sense amplifiers and moving second data from second memory cells to the second sense amplifiers occurs while an access line coupled to the first memory cells and the second memory cells is activated and while the first sense amplifiers and the second sense amplifiers are activated.", "16.The method of claim 15, wherein moving the first data from first memory cells to the first sense amplifiers and moving second data from second memory cells to the second sense amplifiers occurs while the first sense amplifiers and the second sense amplifiers are not equilibrated.", "17.An apparatus, comprising: an array of memory cells comprising first and second groups of memory cells coupled to an access line; a controller coupled to the array; a group of first sensing components coupled to the first group of memory cells and coupled to the controller by a first number of control lines; and a group of second sensing components coupled to the second group of memory cells and coupled to the controller by a second number of control lines; wherein the controller is configured to select the access line and activate first sense amplifiers of the group of first sensing components to transfer first data from the first group of memory cells to the activated first sense amplifiers while the first sense amplifiers are not equilibrated, and while second sense amplifiers of the group of second sensing components are equilibrated and not activated; and wherein the controller is configured to activate second sense amplifiers of the group of second sensing components to move second data from the second sense amplifiers to compute components of the group of second sensing components and from the second sense amplifiers to second group of memory cells concurrently while the second sense amplifiers are not equilibrated, while the first sense amplifiers not are equilibrated and activated, and while the access line is selected.", "18.The apparatus of claim 17, wherein the second sensing components are configured to transfer the second data from the second compute components to the second sense amplifiers while the second sense amplifiers are equilibrated and not activated.", "19.The apparatus of claim 18, wherein the second data is transferred from the second compute components to the second sense amplifiers in response to the controller activating logical operation selection logic components of the group of second sensing components.", "20.The apparatus of claim 17, wherein the first data is transferred from the first group of memory cells to the activated first sense amplifiers while logical operation selection logic components of the group of first sensing components is not activated, and wherein the first sensing components are configured to transfer the first data from the activated first sense amplifiers to compute components of the group of first sensing components in response to the controller activating the logical operation selection logic components while the first sense amplifiers are not equilibrated." ], [ "<SOH> BACKGROUND <EOH>Memory devices are typically provided as internal, semiconductor, integrated circuits in computers or other electronic systems.", "There are many different types of memory including volatile and non-volatile memory.", "Volatile memory can require power to maintain its data (e.g., host data, error data, etc.)", "and includes random access memory (RAM), dynamic random access memory (DRAM), static random access memory (SRAM), synchronous dynamic random access memory (SDRAM), and thyristor random access memory (TRAM), among others.", "Non-volatile memory can provide persistent data by retaining stored data when not powered and can include NAND flash memory, NOR flash memory, and resistance variable memory such as phase change random access memory (PCRAM), resistive random access memory (RRAIVI), and magnetoresistive random access memory (MRAM), such as spin torque transfer random access memory (STT RAM), among others.", "Electronic systems often include a number of processing resources (e.g., one or more processors), which may retrieve and execute instructions and store the results of the executed instructions to a suitable location.", "A processor can comprise a number of functional units (e.g., herein referred to as functional unit circuitry (FUC)) such as arithmetic logic unit (ALU) circuitry, floating point unit (FPU) circuitry, and/or a combinatorial logic block, for example, which can execute instructions to perform logical operations such as AND, OR, NOT, NAND, NOR, and XOR logical operations on data (e.g., one or more operands).", "A number of components in an electronic system may be involved in providing instructions to the functional unit circuitry for execution.", "The instructions may be generated, for instance, by a processing resource such as a controller and/or host processor.", "Data (e.g., the operands on which the instructions will be executed to perform the logical operations) may be stored in a memory array that is accessible by the FUC.", "The instructions and/or data may be retrieved from the memory array and sequenced and/or buffered before the FUC begins to execute instructions on the data.", "Furthermore, as different types of operations may be executed in one or multiple clock cycles through the FUC, intermediate results of the operations and/or data may also be sequenced and/or buffered.", "In many instances, the processing resources (e.g., processor and/or associated FUC) may be external to the memory array, and data can be accessed (e.g., via a bus between the processing resources and the memory array) to execute instructions.", "Data can be moved from the memory array to registers external to the memory array via a bus." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 is a block diagram of an apparatus in the form of a computing system including a memory device in accordance with a number of embodiments of the present disclosure.", "FIGS.", "2A-2B are schematic diagrams illustrating sensing circuitry in accordance with a number of embodiments of the present disclosure.", "FIG.", "2C is a logic table illustrating selectable logic operation results implemented by sensing circuitry in accordance with a number of embodiments of the present disclosure.", "FIG.", "2D is a schematic diagram illustrating sensing circuitry in accordance with a number of embodiments of the present disclosure.", "FIG.", "3A-3E are timing diagrams illustrating operation of sensing circuitry in accordance with a number of embodiments of the present disclosure.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "PRIORITY INFORMATION This application is a continuation of U.S. application Ser.", "No.", "14/977, 286, filed Dec. 21, 2015, the contents of which are included herein by reference.", "TECHNICAL FIELD The present disclosure relates generally to semiconductor memory apparatuses and methods, and more particularly, to apparatuses and methods related to control lines provided to sensing components.", "BACKGROUND Memory devices are typically provided as internal, semiconductor, integrated circuits in computers or other electronic systems.", "There are many different types of memory including volatile and non-volatile memory.", "Volatile memory can require power to maintain its data (e.g., host data, error data, etc.)", "and includes random access memory (RAM), dynamic random access memory (DRAM), static random access memory (SRAM), synchronous dynamic random access memory (SDRAM), and thyristor random access memory (TRAM), among others.", "Non-volatile memory can provide persistent data by retaining stored data when not powered and can include NAND flash memory, NOR flash memory, and resistance variable memory such as phase change random access memory (PCRAM), resistive random access memory (RRAIVI), and magnetoresistive random access memory (MRAM), such as spin torque transfer random access memory (STT RAM), among others.", "Electronic systems often include a number of processing resources (e.g., one or more processors), which may retrieve and execute instructions and store the results of the executed instructions to a suitable location.", "A processor can comprise a number of functional units (e.g., herein referred to as functional unit circuitry (FUC)) such as arithmetic logic unit (ALU) circuitry, floating point unit (FPU) circuitry, and/or a combinatorial logic block, for example, which can execute instructions to perform logical operations such as AND, OR, NOT, NAND, NOR, and XOR logical operations on data (e.g., one or more operands).", "A number of components in an electronic system may be involved in providing instructions to the functional unit circuitry for execution.", "The instructions may be generated, for instance, by a processing resource such as a controller and/or host processor.", "Data (e.g., the operands on which the instructions will be executed to perform the logical operations) may be stored in a memory array that is accessible by the FUC.", "The instructions and/or data may be retrieved from the memory array and sequenced and/or buffered before the FUC begins to execute instructions on the data.", "Furthermore, as different types of operations may be executed in one or multiple clock cycles through the FUC, intermediate results of the operations and/or data may also be sequenced and/or buffered.", "In many instances, the processing resources (e.g., processor and/or associated FUC) may be external to the memory array, and data can be accessed (e.g., via a bus between the processing resources and the memory array) to execute instructions.", "Data can be moved from the memory array to registers external to the memory array via a bus.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a block diagram of an apparatus in the form of a computing system including a memory device in accordance with a number of embodiments of the present disclosure.", "FIGS.", "2A-2B are schematic diagrams illustrating sensing circuitry in accordance with a number of embodiments of the present disclosure.", "FIG.", "2C is a logic table illustrating selectable logic operation results implemented by sensing circuitry in accordance with a number of embodiments of the present disclosure.", "FIG.", "2D is a schematic diagram illustrating sensing circuitry in accordance with a number of embodiments of the present disclosure.", "FIG.", "3A-3E are timing diagrams illustrating operation of sensing circuitry in accordance with a number of embodiments of the present disclosure.", "DETAILED DESCRIPTION The present disclosure includes apparatuses and methods related to coupling control lines to sensing components.", "A system coupling control lines to sensing components can include a plurality of sensing components coupled to an array of memory cells.", "The plurality of sensing components can include a first group of sensing components coupled to a controller via a first number of control lines and a second group of sensing components coupled to the controller via a second number of control lines.", "The controller can be configured to activate at least one of the first number of control lines and the second number of control lines.", "As used herein, sensing circuitry can include a plurality of sensing components that are on pitch with a number of sense lines.", "Each of the sensing components can include a sense amplifier and a compute component.", "The control lines that couple the sensing components to the controller can allow the controller to control the sense amplifiers and/or the compute component independently from each other.", "That is, the controller can activate a first sense amplifier and/or a first compute component independently from the activation of a second sense amplifier and/or a second compute component.", "In a number of examples, groups of sensing components can be coupled to different control lines.", "For example, a first group of sensing components can be coupled to a first group of control lines and a second group of sensing components can be coupled to a second group of control lines.", "Providing independent control of the sensing components via separate control lines can provide various benefits, such as performing operations (e.g., logical operations) in selected groups of sensing components.", "For example, a first group of sensing components can perform a first operation via a first control line independently of a second group of sensing components that is coupled to a second control line.", "A controller can be used to selectively control which group of sensing components perform which operations via a plurality of control lines.", "Examples of operations that can be performed on selected groups of sensing components include load operations, store operations, copy operations, and/or pattern operations.", "The operations performed in accordance with embodiments described herein can include primary operations (e.g., mathematical operations such as an addition, subtraction, multiplication, and/or division).", "However, embodiments of the present disclosure are not limited to a particular type of operation.", "A primary operation can be performed, for example, by performing a number of logical operations such as AND, OR, NOT, NAND, NOR, and XOR logical operations but are not limited to logical operations.", "Logical operations that are performed to perform a primary operation may be referred to herein as secondary operations.", "In the following detailed description of the present disclosure, reference is made to the accompanying drawings that form a part hereof, and in which is shown by way of illustration how one or more embodiments of the disclosure may be practiced.", "These embodiments are described in sufficient detail to enable those of ordinary skill in the art to practice the embodiments of this disclosure, and it is to be understood that other embodiments may be utilized and that process, electrical, and/or structural changes may be made without departing from the scope of the present disclosure.", "As used herein, the designators “N,” “X,” and “Y,” particularly with respect to reference numerals in the drawings, indicates that a number of the particular feature so designated can be included.", "As used herein, “a number of” a particular thing can refer to one or more of such things (e.g., a number of memory arrays can refer to one or more memory arrays).", "The figures herein follow a numbering convention in which the first digit or digits correspond to the drawing figure number and the remaining digits identify an element or component in the drawing.", "Similar elements or components between different figures may be identified by the use of similar digits.", "For example, 231 may reference element “31” in FIG.", "2, and a similar element may be referenced as 231 in FIG.", "2D.", "As will be appreciated, elements shown in the various embodiments herein can be added, exchanged, and/or eliminated so as to provide a number of additional embodiments of the present disclosure.", "In addition, as will be appreciated, the proportion and the relative scale of the elements provided in the figures are intended to illustrate certain embodiments of the present invention, and should not be taken in a limiting sense.", "FIG.", "1 is a block diagram of an apparatus in the form of a computing system 100 including a memory device 120 in accordance with a number of embodiments of the present disclosure.", "As used herein, a memory device 120, a memory array 130, and/or sensing circuitry 150 might also be separately considered an “apparatus.” System 100 includes a host 110 coupled to memory device 120, which includes a memory array 130.Host 110 can be a host system such as a personal laptop computer, a desktop computer, a digital camera, a mobile telephone, or a memory card reader, among various other types of hosts.", "Host 110 can include a system motherboard and/or backplane and can include a number of processing resources (e.g., one or more processors, microprocessors, or some other type of controlling circuitry).", "The system 100 can include separate integrated circuits or both the host 110 and the memory device 120 can be on the same integrated circuit.", "The system 100 can be, for instance, a server system and/or a high performance computing (HPC) system and/or a portion thereof Although the example shown in FIG.", "1 illustrates a system having a Von Neumann architecture, embodiments of the present disclosure can be implemented in non-Von Neumann architectures (e.g., a Turing machine), which may not include one or more components (e.g., CPU, ALU, etc.)", "often associated with a Von Neumann architecture.", "For clarity, the system 100 has been simplified to focus on features with particular relevance to the present disclosure.", "The memory array 130 can be a DRAM array, SRAM array, STT RAM array, PCRAM array, TRAM array, RRAM array, NAND flash array, and/or NOR flash array, for instance.", "The array 130 can comprise memory cells arranged in rows coupled by access lines and columns coupled by sense lines (which may be referred to herein as digit lines or data lines).", "Although a single array 130 is shown in FIG.", "1, embodiments are not so limited.", "For instance, memory device 120 may include a number of arrays 130 (e.g., a number of banks of DRAM cells).", "An example DRAM array is described in association with FIGS.", "2A, 2B, and 2D.", "The memory device 120 includes address circuitry 142 to latch address signals provided over an I/O bus 156 (e.g., a data bus) through I/O circuitry 144.Address signals are received and decoded by a row decoder 146 and a column decoder 152 to access the memory array 130.Data can be read from memory array 130 by sensing voltage and/or current changes on the sense lines using sensing circuitry 150.The sensing circuitry 150 can read and latch a page (e.g., row) of data from the memory array 130.The I/O circuitry 144 can be used for bi-directional data communication with host 110 over the I/O bus 156.The write circuitry 148 is used to write data to the memory array 130.Controller 140 decodes signals provided by control bus 154 from the host 110.These signals can include chip enable signals, write enable signals, and address latch signals that are used to control operations performed on the memory array 130, including data read, data write, and data erase operations.", "In various embodiments, the controller 140 is responsible for executing instructions from the host 110.The controller 140 can be a state machine, a sequencer, or some other type of controller.", "An example of the sensing circuitry 150 is described further below in association with FIGS.", "2A to 2D.", "For instance, in a number of embodiments, the sensing circuitry 150 can comprise a number of sensing components each of which can comprise a sense amplifier and a compute component, each of which may comprise a latch serving as an accumulator and can be used to perform logical operations (e.g., on data associated with complementary sense lines).", "In a number of embodiments, the sensing circuitry (e.g., 150) can be used to perform operations using data stored in array 130 as inputs and store the results of the operations back to the array 130 without transferring data via an I/O line and/or via a sense line address access (e.g., without firing a column decode signal).", "As such, operations can be performed using sensing circuitry 150 rather than and/or in addition to being performed by processing resources external to the sensing circuitry 150 (e.g., by a processor associated with host 110 and/or other processing circuitry, such as ALU circuitry, located on device 120 (e.g., on controller 140 or elsewhere)).", "In various previous approaches, data associated with an operation, for instance, would be read from memory via sensing circuitry and provided to an external ALU.", "The external ALU circuitry would perform the operations using bit-vectors (which may be referred to as operands or inputs) and the result could be transferred back to the array via the local I/O lines.", "In contrast, in a number of embodiments of the present disclosure, sensing circuitry (e.g., 150) is configured to selectively perform an operation on data stored in memory cells in memory array 130 and store the result back to the array 130 without activating a local I/O line coupled to the sensing circuitry.", "As such, in a number of embodiments, registers and/or an ALU external to array 130 and sensing circuitry 150 may not be needed to perform the operation as the sensing circuitry 150 can be operated to perform the appropriate computations involved in performing the operation.", "Additionally, the operation can be performed without the use of an external processing resource.", "FIG.", "2A is a schematic diagram illustrating sensing circuitry capable of implementing a number of logical operations in accordance with a number of embodiments of the present disclosure.", "FIG.", "2A shows a number of sense amplifiers 206 coupled to respective pairs of complementary sense lines 205-1 and 205-2, and a corresponding number of compute components 231 coupled to the sense amplifiers 206 via pass gates 207-1 and 207-2.The sense amplifiers 206 and compute components 231 shown in FIG.", "2A can correspond to sensing circuitry 150 shown in FIG.", "1, for example.", "The sensing circuitry shown in FIG.", "2A includes logical operation selection logic 213, which can be operated as described further below.", "Although not shown, memory cells are coupled to the pairs of complementary sense lines 205-1 and 205-2 (e.g., columns).", "The memory cells can be, for example, 1T1C DRAM cells each comprising a storage element (e.g., capacitor) and an access device (e.g., transistor).", "For example, a memory cell can comprise a transistor and a capacitor.", "In a number of embodiments, the memory cells may be destructive read memory cells (e.g., reading the data stored in the cell destroys the data such that the data originally stored in the cell is refreshed after being read).", "The cells of the memory array can be arranged in rows coupled by word lines and columns coupled by pairs of complementary data lines DIGIT(n−1)/DIGIT(n−1)_, DIGIT(n)/DIGIT(n)_, DIGIT(n+1)/DIGIT(n+1)_.", "The individual data lines corresponding to each pair of complementary data lines can also be referred to as data lines 205-1 (D) and 205-2 (D_) respectively.", "Although only three pairs of complementary data lines (e.g., three columns) are shown in FIG.", "2A, embodiments of the present disclosure are not so limited, and an array of memory cells can include additional columns of memory cells and/or data lines (e.g., 4,096, 8,192, 16,384, etc.).", "Memory cells can be coupled to different data lines and/or word lines.", "For example, a first source/drain region of an access transistor of a memory cell can be coupled to a data line 205-1 (D), a second source/drain region of the access transistor of the memory cell can be coupled to a capacitor of the memory cell, and a gate of the access transistor of the memory cell can be coupled to a word line of the memory array.", "As shown in FIG.", "2A, the sensing circuitry can comprise a sense amplifier 206, a compute component 231, and logical operation selection logic 213 corresponding to respective columns of memory cells (e.g., coupled to respective pairs of complementary data lines).", "The sense amplifier 206 can comprise, for example, a cross coupled latch, which can be referred to herein as a primary latch.", "The sense amplifiers 206 can be configured, for example, as described with respect to FIG.", "2B.", "In the example illustrated in FIG.", "2A, the circuitry corresponding to compute components 231 is configured as a loadable shift register.", "For instance, each compute component 231 comprises a latch, which may be referred to herein as a secondary latch, and an additional number of transistors operable to transfer (e.g., shift) data values right and/or left (e.g., to a latch of an adjacent compute component 231).", "As described further herein, in a number of embodiments, the latch of the compute component 231 can serve as an accumulator.", "As such, the compute component 231 can operate as and/or may be referred to herein as an accumulator.", "The gates of the pass gates 207-1 and 207-2 can be controlled by a logical operation selection logic signal, Pass.", "For example, an output of the logical operation selection logic 213 can be coupled to the gates of the pass gates 207-1 and 207-2, as shown in FIG.", "2A.", "The sensing circuitry shown in FIG.", "2A also shows logical operation selection logic 213 coupled to a number of logic selection control input control lines, including ISO, TF, TT, FT, and FF.", "Selection of a logical operation from a plurality of logical operations is determined from the condition of logic selection control signals on the logic selection control input control lines, as well as the data values present on the pairs of complementary sense lines 205-1 and 205-2 when the isolation transistors (e.g., 250-1 and 250-2) are enabled via the ISO control signal being asserted.", "According to various embodiments, the logical operation selection logic 213 can include four logic selection transistors: logic selection transistor 262 coupled between the gates of the swap transistors 242 and a TF signal control line, logic selection transistor 252 coupled between the gates of the pass gates 207-1 and 207-2 and a TT signal control line, logic selection transistor 254 coupled between the gates of the pass gates 207-1 and 207-2 and a FT signal control line, and logic selection transistor 264 coupled between the gates of the swap transistors 242 and a FF signal control line.", "Gates of logic selection transistors 262 and 252 are coupled to the true sense line through isolation transistor 250-1 (having a gate coupled to an ISO signal control line).", "Gates of logic selection transistors 264 and 254 are coupled to the complementary sense line through isolation transistor 250-2 (also having a gate coupled to an ISO signal control line).", "Data values present on the pair of complementary sense lines 205-1 and 205-2 can be loaded into the compute component 231 via the pass gates 207-1 and 207-2.When the pass gates 207-1 and 207-2 are OPEN, data values on the pair of complementary sense lines 205-1 and 205-2 are passed to the compute component 231 and thereby loaded into the loadable shift register.", "The data values on the pair of complementary sense lines 205-1 and 205-2 can be the data value stored in the sense amplifier 206 when the sense amplifier is enabled (e.g., fired).", "The logical operation selection logic signal, Pass, is activated to OPEN (e.g., turn on) the pass gates 207-1 and 207-2.The ISO, TF, TT, FT, and FF control signals can operate to select a logical operation to implement based on the data value (“B”) in the sense amplifier 206 and the data value (“A”) in the compute component 231 (e.g., as used herein, the data value stored in a latch of a sense amplifier is referred to as a “B” data value, and the data value stored in a latch of a compute component is referred to as an “A” data value).", "In particular, the ISO, TF, TT, FT, and FF control signals are configured to select the logical operation (e.g., function) to implement independent from the data value present on the pair of complementary sense lines 205-1 and 205-2 (although the result of the implemented logical operation can be dependent on the data value present on the pair of complementary sense lines 205-1 and 205-2.That is, the ISO, TF, TT, FT, and FF control signals select the logical operation to implement directly since the data value present on the pair of complementary sense lines 205-1 and 205-2 is not passed through logic to operate the gates of the pass gates 207-1 and 207-2.Additionally, FIG.", "2A shows swap transistors 242 configured to swap the orientation of the pair of complementary sense lines 205-1 and 205-2 between the sense amplifier 206 and the compute component 231.For instance, when the swap transistors 242 are OPEN (e.g., turned on), data values on the pair of complementary sense lines 205-1 and 205-2 on the sense amplifier 206 side of the swap transistors 242 are oppositely-coupled to the pair of complementary sense lines 205-1 and 205-2 on the compute component 231 side of the swap transistors 242, and thereby loaded into the loadable shift register of the compute component 231 in a complementary manner.", "As an example, the logical operation selection logic signal Pass can be activated (e.g., high) to OPEN (e.g., turn on) the pass gates 207-1 and 207-2 when the ISO control signal line is activated and either the TT control signal is activated (e.g., high) with the data value on the true sense line being “1” or the FT control signal is activated (e.g., high) with the data value on the complement sense line being “1.” The data value on the true sense line being a “1” OPENs logic selection transistors 252 and 262.The data value on the complementary sense line being a “1” OPENs logic selection transistors 254 and 264.If the ISO control signal or either the respective TT/FT control signal or the data value on the corresponding sense line (e.g., sense line to which the gate of the particular logic selection transistor is coupled) is not high, then the pass gates 207-1 and 207-2 will not be OPENed by a particular logic selection transistor.", "The logical operation selection logic signal Pass* can be activated (e.g., high) to OPEN (e.g., turn on) the swap transistors 242 when the ISO control signal line is activated and either the TF control signal is activated (e.g., high) with data value on the true sense line being “1,” or the FF control signal is activated (e.g., high) with the data value on the complement sense line being “1.” If either the respective control signal or the data value on the corresponding sense line (e.g., sense line to which the gate of the particular logic selection transistor is coupled) is not high, then the swap transistors 242 will not be OPENed by a particular logic selection transistor.", "The sensing circuitry illustrated in FIG.", "2A is configured to select one of a plurality of logical operations to implement directly from the four logic selection control signals (e.g., logical operation selection is not dependent on the data value present on the pair of complementary sense lines).", "Some combinations of the logic selection control signals can cause both the pass gates 207-1 and 207-2 and swap transistors 242 to be OPEN (e.g., conducting) at the same time, which shorts the pair of complementary sense lines 205-1 and 205-2 together.", "According to a number of embodiments of the present disclosure, the logical operations which can be implemented by the sensing circuitry illustrated in FIG.", "2A can be the logical operations summarized in the logic tables shown in FIG.", "2C.", "Although not shown in FIG.", "2A, each column of memory cells can be coupled to a column decode line that can be activated to transfer, via a local I/O line, a data value from a corresponding sense amplifier 206 and/or compute component 231 to a control component external to the array such as an external processing resource (e.g., host processor and/or other functional unit circuitry).", "The column decode line can be coupled to a column decoder.", "However, as described herein, in a number of embodiments, data need not be transferred via such I/O lines to perform logical operations in accordance with embodiments of the present disclosure.", "In a number of embodiments, shift circuitry can be operated in conjunction with sense amplifiers 206 and compute components 231 to perform logical operations without transferring data to a control component external to the array, for instance.", "As used herein, transferring data, which may also be referred to as moving data is an inclusive term that can include, for example, copying data from a source location to a destination location and/or moving data from a source location to a destination location without necessarily maintaining a copy of the data at the source location.", "As noted above, the compute components 231 can comprise a loadable shift register.", "In this example, each compute component 231 is coupled to a corresponding pair of complementary data lines 205-1/205-2, with a node ST2 being coupled to the particular data line (e.g., DIGIT(n)) communicating a “true” data value and with node SF2 being coupled to the corresponding complementary data line (e.g., DIGIT(n)_) communicating the complementary data value (e.g., “false” data value).", "In this example, the loadable shift register comprises a first right-shift transistor 281 of a particular compute component 231 having a gate coupled to a first right-shift control line 282 (e.g., PHASE 1R), and a second right-shift transistor 286 of the particular compute component 231 having a gate coupled to a second right-shift control line 283 (e.g., PHASE 2R).", "Node ST2 of the particular control component is coupled to an input of a first inverter 287, whose output (e.g., node SF1) is coupled to a first source/drain region of transistor 286.The second source/drain region of transistor 286 is coupled to the input (e.g., node SF2) of a second inverter 288.The output (e.g., node ST1) of inverter 288 is coupled to a first source/drain region of transistor 281, and a second source/drain region of transistor 281 the particular compute component 231 is coupled to an input (e.g., node ST2) of a first inverter 287 of an adjacent compute component 231.The loadable shift register shown in FIG.", "2A includes a first left-shift transistor 289 coupled between node SF2 of a particular compute component and node SF1 of an adjacent compute component 231.The loadable shift register shown in FIG.", "2A also includes a second left-shift transistor 290 of a particular compute component 231 having a first source/drain region coupled to node ST2 and a second source/drain region coupled to node ST1.The gate of the first left-shift transistor 289 is coupled to a first left-shift control line 291 (e.g., PHASE 1L), and the gate of the second left-shift transistor 290 is coupled to a second left-shift control line 492 (e.g., PHASE 2L).", "In operation, a data value on a pair of complementary data lines (e.g., 205-1/205-2) can be loaded into a corresponding compute component 231 (e.g., by operating logical operation selection logic as described above).", "As an example, a data value can be loaded into a compute component 231 via overwriting of the data value currently stored in the compute component 231 with the data value stored in the corresponding sense amplifier 206.Alternatively, a data value may be loaded into a compute component by deactivating the control lines 282, 283, 291, and 292.Once a data value is loaded into a compute component 231, the “true” data value is separated from the complement data value by the first inverter 287.Shifting data to the right (e.g., to an adjacent compute component 231) can include alternating operation of the first right-shift transistor 281 and the second right-shift transistor 286, for example, via the PHASE 1R and PHASE 2R control signals being periodic signals that go high out of phase from one another (e.g., non-overlapping alternating square waves 180 out of phase).", "The transistor 290 can be turned on to latch the shifted data value.", "An example of shifting data left via the shift register shown in FIG.", "2A can include operating control signals 291 and 292 to move a data value one control component to the left through transistors 289 and 290.Data from node ST2 is inverted through inverter 287 to node SF1.Activation of control signal 291 causes the data from node SF1 to move left through transistor 289 to node SF2 of a left-adjacent compute component 231.Data from node SF2 is inverted through inverter 288 to node ST1.Subsequent activation of control signal 292 causes the data from node ST1 to move through transistor 290 left to node ST2, which completes a left shift by one compute component 231.Data can be “bubbled” to the left by repeating the left shift sequence multiple times.", "Data values can be latched (and prevented from being further shifted) by maintaining the control signal 292 activated.", "Embodiments of the present disclosure are not limited to the shifting capability described in association with the compute components 231.For example, a number of embodiments and include shift circuitry in addition to and/or instead of the shift circuitry described in association with a loadable shift register.", "The sensing circuitry in FIG.", "2A can be operated in several modes to perform logical operations, including a first mode in which a result of the logical operation is initially stored in the sense amplifier 206, and a second mode in which a result of the logical operation is initially stored in the compute component 231.Additionally with respect to the first operating mode, sensing circuitry can be operated in both pre-sensing (e.g., sense amplifiers fired before logical operation control signal active) and post-sensing (e.g., sense amplifiers fired after logical operation control signal active) modes with a result of a logical operation being initially stored in the sense amplifier 206.In a number of examples, the sense amplifier 206 and the compute component 231 can be in at least one of two states associated with the first mode and the second mode.", "As used herein, a state of a sense amplifier 206 and/or the compute component 231 describes a transfer of data between the sense amplifier 206 and/or the compute component 231.The state of the sense amplifier 206 and the compute component 231 can also be described as the state of a sensing component.", "The state of a sensing component can be based on whether the sense amplifier 206 is in an equilibration state or is storing a data value (e.g., logic “0” or logic “1”).", "That is, a sense amplifier can be configured to be in an initial state, wherein the initial state is one of an equilibration state and a data storage state.", "An equilibration state includes the sense amplifier 206 being in an equilibration state.", "A data storage state includes the sense amplifiers 206 storing a data value.", "As used herein, a data value can be referred to as a bit and/or a digit value.", "Data can be transferred from a compute component 231 to a sense amplifier 206 in response to enabling a pass gate (e.g., activating the PASS and/or PASS* control signals via the TF 262, TT 252, FT 254, and/or FF 264 control signals that are referred to herein as a logical operation selection logic) and the sense amplifier 206 being in a equilibration state.", "Data can be transferred from a sense amplifier 206 to a compute component 231 in response to enabling the pass gate (e.g., activating the PASS and/or PASS* control signals via the TF 262, TT 252, FT 254, and/or FF 264 control signals that are referred to herein as a logical operation selection logic) and the sense amplifier 206 being in a data storage state.", "The direction of the transfer of data between the sense amplifier 206 and the compute component 231 is determined by whether the sense amplifier 206 is in an equilibration state or stores a data value before the PASS and/or PASS* control signals are activated and by a particular operation selected via the logical operation selection logic (e.g., TF 262, TT 252, FT 254, and FF 264 control signals).", "For example, if the sense amplifier 206 is equilibrated and the PASS and/or PASS* control signals are activated to provide a conduction path (e.g., electrical continuity) between the sense amplifier 206 and the compute component 231, then a data value stored in the compute component 231 can be transferred from the compute component 231 to the sense amplifier 206.If the sense amplifier 206 is configured to store a first bit (e.g., first data value) and the PASS and/or PASS* control signals are activated to provide a conduction path between the sense amplifier 206 and the compute component 231, then a second bit (e.g., second data value) that is stored in the compute component 231 before the activation of the PASS and/or PASS* control signals can be replaced by the first bit and the sense amplifier 206 retains the first bit.", "Furthermore, a number of operations can be performed using the first bit and the second bit using the logical operation selection logic and the result of the operation can be stored in the compute component 231.Using an equilibration signal to direct the transfer of data between the sense amplifier 206 and the compute component 231 can provide the ability to selectively perform an operation in sense amplifiers that are not equilibrated without performing the operation in sense amplifiers that are equilibrated.", "That is, a PASS and/or a PASS* control signal can be activated in a plurality of sensing components to move data between a first group of a plurality of sense amplifiers that are equilibrated and a first group of a plurality of compute components.", "The PASS and/or PASS* control signals can also be activated to move data between a second group of the plurality of sense amplifiers and a second group of the plurality of component components that are not equilibrated to selectively perform an operation in a second group of sense components while not performing the operation on a first group of sense components.", "FIG.", "2B illustrates a schematic diagram of a portion of sensing circuitry in accordance with a number of embodiments of the present disclosure.", "According to various embodiments, sense amplifier 206 can comprise a cross coupled latch.", "However, embodiments of the sense amplifier 206 are not limited to a cross coupled latch.", "As an example, the sense amplifier 206 in FIG.", "2B can be current-mode sense amplifier and/or single-ended sense amplifier (e.g., sense amplifier coupled to one data line).", "Also, embodiments of the present disclosure are not limited to a folded data line architecture.", "In a number of embodiments, a sense amplifier (e.g., 206) can comprise a number of transistors formed on pitch with the transistors of the corresponding compute component 231 and/or the memory cells of an array (e.g., 230 shown in FIG.", "2A) to which they are coupled, which may conform to a particular feature size (e.g., 4F2, 6F2, etc.).", "Sense amplifier 206 comprises a latch 215 including four transistors coupled to a pair of complementary data lines D 205-1 and D_205-2.The latch 215 can be a cross coupled latch.", "That is, the gates of a pair of transistors, such as n-channel transistors (e.g., NMOS transistors) 227-1 and 227-2 are cross coupled with the gates of another pair of transistors, such as p-channel transistors (e.g., PMOS transistors) 229-1 and 229-2.As described further herein, the latch 215 comprising transistors 227-1, 227-2, 229-1, and 229-2 can be referred to as a primary latch.", "However, embodiments are not limited to this example.", "The voltages or currents on the respective data lines D and D_ can be provided to the respective latch inputs 233-1 and 233-2 of the cross coupled latch 215 (e.g., the input of the primary latch).", "In this example, the latch input 233-1 is coupled to a first source/drain region of transistors 227-1 and 229-1 as well as to the gates of transistors 227-2 and 229-2.Similarly, the latch input 233-2 can be coupled to a first source/drain region of transistors 227-2 and 229-2 as well as to the gates of transistors 227-1 and 229-1.The compute component 231, which may be referred to herein as an accumulator, can be coupled to latch inputs 233-1 and 233-2 of the cross coupled latch 215 as shown; however, embodiments are not limited to the example shown in FIG.", "2B.", "In this example, a second source/drain region of transistor 227-1 and 227-2 is commonly coupled to an RnIF 228.A second source/drain region of transistors 229-1 and 229-2 is commonly coupled to an ACT signal 265.The ACT signal 265 can be a supply voltage (e.g., VDD) and the RnIF signal can be a reference voltage (e.g., ground).", "Activating signals 228 and 265 enables the cross coupled latch 215.The enabled cross coupled latch 215 operates to amplify a differential voltage between latch input 233-1 (e.g., first common node) and latch input 233-2 (e.g., second common node) such that latch input 233-1 is driven to one of the ACT signal voltage and the RnIF signal voltage (e.g., to one of VDD and ground), and latch input 233-2 is driven to the other of the ACT signal voltage and the RnIF signal voltage.", "The sense amplifier 206 can also include circuitry configured to equilibrate the data lines D and D_ (e.g., in association with preparing the sense amplifier for a sensing operation).", "In this example, the equilibration circuitry comprises a transistor 224 having a first source/drain region coupled to a first source/drain region of transistor 225-1 and data line D 205-1.A second source/drain region of transistor 224 can be coupled to a first source/drain region of transistor 225-2 and data line D_205-2.A gate of transistor 224 can be coupled to gates of transistors 225-1 and 225-2.The second source drain regions of transistors 225-1 and 225-2 are coupled to an equilibration voltage 238 (e.g., VDD/2), which can be equal to VDD/2, where VDD is a supply voltage associated with the array.", "The gates of transistors 224, 225-1, and 225-2 can be coupled to control signal 226 (EQ).", "As such, activating EQ enables the transistors 224, 225-1, and 225-2, which effectively shorts data line D to data line D_ such that the data lines D and D_ are equilibrated to equilibration voltage VDD/2.According to a number of embodiments of the present disclosure, a number of logical operations can be performed using the sense amplifier 206 and compute component 231, and the result can be stored in the sense amplifier and/or compute component.", "The sensing circuitry 250-2 in FIG.", "2A can be operated in several modes to perform logical operations, including a first mode in which a result of the logical operation is initially stored in the sense amplifier 206, and a second mode in which a result of the logical operation is initially stored in the compute component 231.Additionally, with respect to the first operating mode, sensing circuitry 250-2 can be operated in both pre-sensing (e.g., sense amplifiers fired before logical operation control signal active) and post-sensing (e.g., sense amplifiers fired after logical operation control signal active) modes with a result of a logical operation being initially stored in the sense amplifier 206.As described further below, the sense amplifier 206 can, in conjunction with the compute component 231, be operated to perform various logical operations using data from an array as input.", "In a number of embodiments, the result of a logical operation can be stored back to the array without transferring the data via a data line address access (e.g., without firing a column decode signal such that data is transferred to circuitry external to the array and sensing circuitry via local I/O lines).", "As such, a number of embodiments of the present disclosure can enable performing various operations (e.g., logical operations, mathematical operations, etc.)", "using less power than various previous approaches.", "Additionally, since a number of embodiments eliminate the need to transfer data across I/O lines in order to perform operations (e.g., between memory and discrete processor), a number of embodiments can enable an increased parallel processing capability as compared to previous approaches.", "FIG.", "2C is a logic table illustrating selectable logic operation results implemented by a sensing circuitry in accordance with a number of embodiments of the present disclosure.", "The four logic selection control signals (e.g., TF, TT, FT, and FF), in conjunction with a particular data value present on the complementary sense lines, can be used to select one of plural logical operations to implement involving the starting data values stored in the sense amplifier 206 and compute component 231.The four control signals, in conjunction with a particular data value present on the complementary sense lines, controls the state (conducting or not conducting) of the pass gates 207-1 and 207-2 and swap transistors 242, which in turn affects the data value in the compute component 231 and/or sense amplifier 206 before/after firing.", "The capability to selectably control the state of the swap transistors 242 facilitates implementing logical operations involving inverse data values (e.g., inverse operands and/or inverse result), among others.", "Logic Table 213-1 illustrated in FIG.", "2C shows the starting data value stored in the compute component 231 in FIG.", "2A shown in column A at 244, and the starting data value stored in the sense amplifier 206 shown in column B at 245.The other 3 column headings in Logic Table 213-1 refer to the state of the pass gates 207-1 and 207-2, and the swap transistors 242, which can respectively be controlled to be OPEN (e.g., conducting/on) or CLOSED (e.g., not conducting/off) depending on the state of the four logic selection control signals (e.g., TF, TT, FT, and FF), in conjunction with a particular data value present on the pair of complementary sense lines 205-1 and 205-2 when the ISO control signal is asserted.", "The “Not Open” column corresponds to the pass gates 207-1 and 207-2 and the swap transistors 242 both being in a non-conducting condition, the “Open True” corresponds to the pass gates 207-1 and 207-2 being in a conducting condition, and the “Open Invert” corresponds to the swap transistors 242 being in a conducting condition.", "The configuration corresponding to the pass gates 207-1 and 207-2 and the swap transistors 242 both being in a conducting condition is not reflected in Logic Table 213-1 since this results in the sense lines being shorted together.", "The logic tables illustrated in FIG.", "2C reflect a result initially stored in the compute component 231 in FIG.", "2A.", "Therefore, when the pass gates 207-1 and 207-2 are controlled to be CLOSED (e.g., not conducting), the result initially stored in the compute component 231 is the same as the starting data value in the compute component 231.However, since the sense sensing circuitry 250 is configured such that the sense amplifier 206 can overpower the compute component 231 as shown in the “Not Open” column 256 of the Logic Table 213-1, the result initially stored in the compute component 231 is the same as the starting data value in the sense amplifier 206 when the pass gates 207-1 and 207-2 are controlled to be OPEN (e.g., conducting) as shown in the “Open True” column 270 of the Logic Table 213-1.The compute component 231 can be inverted as shown in the “Open Invert” column 271 when the swap transistors 242 are in a conducting condition.", "Via selective control of the state of the pass gates 207-1 and 207-2 and the swap transistors 242, each of the three columns of the upper portion of Logic Table 213-1 can be combined with each of the three columns of the lower portion of Logic Table 213-1 to provide 3×3 =9 different result combinations, corresponding to nine different logical operations, as indicated by the various connecting paths shown at 275.The nine different selectable logical operations that can be implemented by the sensing circuitry 250 are summarized in Logic Table 213-2 illustrated in FIG.", "2C.", "The columns of Logic Table 213-2 illustrated in FIG.", "2C show a heading 280 that includes the state of logic selection control signals.", "For example, the state of a first logic selection control signal is provided in row 276, the state of a second logic selection control signal is provided in row 277, the state of a third logic selection control signal is provided in row 278, and the state of a fourth logic selection control signal is provided in row 279.The particular logical operation corresponding to the results is summarized in row 247.For example, the results for the values of FF, FT, TF, and TT of “0000” are summarized as “A” since the result (initially stored in the compute component after the sense amplifier fires) is the same as the starting value in the compute component.", "Other columns of results are similarly annotated in row 247, where “A*B” intends A AND B, “A+B” intends A OR B, and “AXB” intends A XOR B.", "By convention, a bar over a data value or a logical operation indicates an inverted value of the quantity shown under the bar.", "For example, AXB bar intends not A XOR B, which is also A XNOR B.", "FIG.", "2D is a schematic diagram illustrating sensing circuitry in accordance with a number of embodiments of the present disclosure.", "The array 230 includes memory cells coupled to rows of access lines and columns of sense lines 205-0, 205-1, 205-2, .", ".", ".", ", 205-(N−1) (referred to generally as 205).", "Memory array 230 is not limited to a particular number of access lines and/or sense lines, and use of the terms “rows” and “columns” does not intend a particular physical structure and/or orientation of the access lines and/or sense lines.", "Although not shown, each column of memory cells can be associated with a corresponding pair of complementary sense lines (e.g., complementary sense lines 205-1 and 205-2 in FIG.", "2A).", "Each column of memory cells can be coupled to sensing circuitry (e.g., sensing circuitry 150 shown in FIG.", "1).", "In this example, the sensing circuitry comprises a number of sensing components.", "Each of the number of sensing components comprises a sense amplifier (referred to generally as sense amplifier 206) and a compute component (referred to generally as compute component 231).", "In FIG.", "2D, array 230 includes sense amplifiers 206-0 to 206-(N−1) and corresponding compute components 231-0 to 231-(N−1).", "The number of sense amplifiers 206 are coupled to the respective sense lines 205.The sense amplifiers 206 are coupled to input/output (I/O) line 234 (e.g., a local I/O line) via corresponding transistors 208-0, 208-1, 208-2, .", ".", ".", ", 208-(N−1).", "In this example, the sensing circuitry also comprises a number of compute components 231 coupled to the respective sense lines 205.Column decode lines 210-0 to 210-(N−1) are coupled to the gates of transistors 208-0 to 208-(N−1), respectively, and can be selectively activated to transfer data sensed by respective sense amplifiers 206-0 to 206-(N−1) and/or stored in respective compute components 231-0 to 231-(N−1) to a secondary sense amplifier 212.In a number of embodiments, the compute components 231 can be formed on pitch with the memory cells of their corresponding columns and/or with the corresponding sense amplifiers 206.In a number of examples, the sensing components can be divided into a plurality of groups and each of the plurality of groups can be coupled to a plurality of different control lines (e.g., control lines that couple the plurality of groups of the sensing components to a controller such as controller 140 shown in FIG.", "1).", "In FIG.", "2D, the sensing components are divided into two groups.", "However, the sensing components can be divided into three or more groups.", "In this example, a first group of sensing components comprises those sensing components corresponding to odd numbered columns (e.g., sense amplifiers 206-1, .", ".", ".", ", 206-(N−3), and 206-(N−1) and corresponding compute components 231-1, .", ".", ".", ", 231-(N−3), and 231-(N−1)), and a second group of sensing components comprises those sensing components corresponding to even numbered columns (e.g., sense amplifier 206-0, 206-2, .", ".", ".", ", 206-(N−4), and 206-(N−2) and corresponding compute components 231-0, 231-2, .", ".", ".", ", 231-(N−4), 231-(N−2)).", "In FIG.", "2D, each particular group of sensing components does not comprise consecutive sensing components.", "That is, the sensing components of first and second groups are interleaved such that the sensing components of a particular group are not physically adjacent to each other.", "In this example, each sensing component from the first group of sensing components is physically next to a sensing component from the second group of sensing components.", "In a number of examples, the sensing components can be grouped such that each particular group comprises a number of consecutive sensing components.", "Groups of sensing components that are divided into a number of groups of consecutive sensing components can be referred to as “blocks” of sensing components.", "In a number of examples, an array can comprise 16,384 columns (e.g., 16,384 sense lines 205, or pairs of complementary sense lines).", "That is, N can be equal to 16,384.As such, there can be 16,384 sensing components each including one of 16,384 sense amplifiers 206 and a corresponding one of 16,384 compute components 231.While in FIG.", "2D the sensing components are divided into two groups, embodiments are not limited to a particular number of groups of sensing components.", "For example, the sensing components can be divided into more than two groups (e.g., four groups, five groups, eight groups, etc.).", "Each of the groups of sensing components can be coupled to a different number of control lines.", "For example, the first group of sensing components is coupled to control lines 226-1, 264-1, and 228-1.The second group of sensing components is coupled to control lines 226-2, 265-2, and 228-2.Control lines 226-1 and 226-2 are equilibration (EQ) control lines.", "Control lines 264-1 and 264-2 are active positive (ACT) control lines.", "Control lines 228-1 and 228-2 are active negative (RnIF) control lines.", "In an example in which the sensing components are divided into eight groups, eight groups of control lines could be provided to the eight respective groups from a controller (e.g., controller 140 shown in FIG.", "1), and each of the eight groups of control lines can include separate EQ control lines, an ACT control lines, and/or RnIF control lines.", "A controller (e.g., 140) can utilize the control lines 226-1, 226-2, 265-1, 265-2, 228-1, and 228-2 to selectively perform operations using the sensing components by activating a first plurality of control lines 226-1, 265-1, and 228-1 independently from the second plurality of control lines 226-2, 265-2, and 228-1.The first plurality of control lines 226-1, 265-1, and 228-1 can be independent from the second plurality of control lines 226-2, 265-2, and 228-1 via a physical separation.", "That is, the first plurality of control lines 226-1, 265-1, and 228-1 can couple a first group of sensing components to a controller without coupling a second group of sensing components to the controller.", "The second plurality of control lines 226-2, 265-2, and 228-2 can couple the second group of sensing components to the controller without coupling the first group of sensing components to the controller.", "As used herein, the term selectively is used to denote that various options may be available from which to choose.", "For example, selectively performing an operation can include performing operations on a first group of sensing components and while not performing the operation on a second group of sensing components.", "For example, a controller (e.g., 140) can activate the control lines 226-1 to equilibrate the first group of sensing components without equilibrating the second group of sensing components (e.g., such that the sense amplifiers of the first group of sensing components are in an equilibrated state while the sense amplifiers corresponding to the second group of sensing components remain in a non-equilibrated state).", "The control line 226-2 can be activated to equilibrate the second group of sensing components without equilibrating the first group of sensing components.", "The control lines 226-1, 265-1, and 228-1 can also be activated to perform an operation on the first group of sensing components without performing the operation on the second group of sensing components.", "The control lines 226-2, 265-2, and 228-2 can be activated to perform an operation in the second group of sensing components without performing the operation in the first group of sensing components.", "At least one of the control lines 226-1, 226-2, 265-1, 265-2, 228-1, and 228-2 can be activated to selectively provide the control signals to the groups of sensing components.", "Each of the groups of sensing components can be configured to receive the number of control signals via the control lines 226-1, 226-2, 265-1, 265-2, 228-1, and/or 228-2.For example, the EQ control lines 226-1 and 226-2 can be activated to provide an EQ signal, the ACT control lines 265-1 and 265-2 can be activated to provide an ACT signal, and/or the RnIF control lines 228-1 and 228-2 can be activated to provide an RnIF control signal.", "In a number of examples, a plurality of sensing components can correspond to a respective plurality of columns of an array.", "The plurality of sensing components can be configured to receive a control signal from the controller.", "The controller can be configured to selectively provide the control signal to the plurality of sensing components.", "Each of the plurality of sensing components can be configured to receive a number of control signals.", "The plurality of sensing components can comprise a first group of sensing components coupled to the controller via the first number of control lines and a second group of sensing components coupled to the controller via a second number of control lines.", "The controller can be configured to selectively activate at least one of the first number of control lines and the second number of control lines.", "FIGS.", "3A to 3E include examples of selectively performing operations.", "For example, FIG.", "3A provides an example of selectively modifying memory cells coupled to an access line (e.g., a row of cells) using data stored in a plurality of compute components.", "That is, FIG.", "3A provides an example of selectively storing data in memory cells coupled to a particular row.", "FIG.", "3B provides an example of selectively modifying a plurality of compute components using data stored in memory cells coupled to a row.", "That is, FIG.", "3B provides an example of selectively loading data into a plurality of compute components.", "FIG.", "3C provides an example of selectively copying data from memory cells coupled to a first row to memory cells coupled to a second row.", "FIG.", "3D provides an example of selectively generating patterns of zeros and ones.", "In a number of examples, the sense amplifiers can be selectively activated to selectively perform an operation.", "That is, a first group of the sense amplifiers can be activated while a second group of the sense amplifiers is not activated to move data between a plurality of compute components and the first group of the sense amplifiers and the second group of the sense amplifiers.", "The sense amplifiers are activated by enabling an ACT signal 265 and RnIF signal 228 as shown in FIG.", "2C.", "Activating a sense amplifier includes deactivating an equilibration signal (e.g., EQ) such that a data value is stored (e.g., latched) in the sense amplifier.", "FIG.", "3E provides an example of selectively storing data in memory cells coupled to a row and updating a plurality of compute components with the stored data by selectively activating sense amplifiers.", "FIG.", "3A is a timing diagram illustrating operation of the sensing circuitry in accordance with a number of embodiments of the present disclosure.", "FIG.", "3A provides an example of selectively modifying memory cells coupled to a row using data stored in a plurality of compute components.", "As used herein, modifying a memory cell refers to overwriting a data value (e.g., bit) stored in the memory cell.", "The example shown in FIG.", "3A involves a plurality of memory cells that are coupled to a particular access line (e.g., row).", "Selectively modifying the plurality of memory cells includes not modifying data stored in a first number of groups of the plurality of memory cells and modifying data stored in a second number of groups of the plurality of memory cells.", "For example, memory cells can be modified in three groups of memory cells and remain unmodified in three other groups of memory cells.", "In FIG.", "3A, there are two groups of memory cells.", "A first group of memory cells is not modified and a second group of memory cells is modified.", "The first group of memory cells is coupled to a first plurality of sense lines.", "The first plurality of sense lines are coupled to a first group of sensing components comprising sense amplifiers and compute components.", "The second group of memory cells is coupled to a second plurality of sense lines.", "The second plurality of sense lines is coupled to a second group of sensing components comprising sense amplifiers and compute components.", "FIG.", "3A illustrates a number of control signals associated with operating sensing circuitry (e.g., 250-2 in FIG.", "2A).", "“EQ” corresponds to an equilibrate signal applied to the sense amplifier 206-2 (e.g., via an equilibrate control line), “FUNCTION” corresponds to signals applied to PASS and/or PASS* gates that are controlled by a logical operation selection logic including the TF, TT, FT, and FF control signals, “ROW” corresponds to an activation signal applied to an access line, “SENSE AMP” corresponds to activation signal applied to a sense amplifier.", "The TF, TT, FT, and FF control signals can be provided to the sense components via a number of function lines.", "FIG.", "3A also illustrates the waveform diagrams showing the signals (e.g., voltage signals) on a first group of digit lines D and D_ (e.g., 305-1) coupled to a first group of sense amplifiers and on a second group of digit lines D and D_ (e.g., 305-2) coupled to a second group of sense amplifiers.", "FIG.", "3A also illustrates the waveform diagrams showing the signals (e.g., voltage signals) on the nodes S and S* corresponding to the compute component (e.g., accumulator) during the selective store operation.", "The particular timing diagram waveforms are discussed below with respect to the pseudo code associated with selectively storing data in memory cells.", "An example of pseudo code associated with selectively storing data in memory cells can be summarized as follows: Deactivate EQ; Applying function lines; Trigger EQ signal except where operation is desired; Open Row and Fire Sense Amplifiers; Close Row; Equilibrate; In the pseudo code above, “Deactivate EQ” indicates that an equilibration signal (EQ signal shown in FIG.", "3A) corresponding to a first group of sense amplifiers and a second group of sense amplifiers is disabled at t1 as shown in FIG.", "3A.", "As such, at t1 the voltage on the complementary data lines 305-1 and 305-2 (e.g., D and D_) is VDD/2.“Apply function lines” as shown in the above pseudocode can refer to activating appropriate control signals (e.g., TF, TT, FT, and FF shown in FIG.", "2D) coupled to the sense amplifiers corresponding to the first group of sense amplifiers and the second group of sense amplifiers to perform a selected operation (e.g., as described above in FIGS.", "2A and 2C).", "As shown in FIG.", "3A, at t2 the Function signal is activated indicating activation of appropriate control signals corresponding to a selected operation.", "S and S* are shown to indicate data values present in the compute components.", "Data values (e.g., bits) stored in the plurality of compute components corresponding to first and second groups of sense amplifiers can be transferred from the plurality of compute components to the first sense amplifiers and the second sense amplifiers responsive to the equilibration state of the sense amplifiers.", "For instance, if a sense amplifier is equilibrated during activation of the function lines, then data is transferred from a compute component to the corresponding sense amplifier.", "If a sense amplifier is not equilibrated during activation of the function lines, then the data value stored in the sense amplifier is transferred from the sense amplifier to the corresponding compute component.", "As such, the first group of sense amplifiers and the second group of second sense amplifiers can store a copy of the data stored in the plurality of corresponding compute components subsequent to activation of the function lines.", "FIG.", "3A shows data as being present on the complementary data lines 305-1 and 305-2 at t3.A voltage corresponding to a logic 1 (e.g., VDD) or a voltage corresponding to a logic 0 (e.g., GND) is shown as being on data line 305-1 (D) and data line 305-2 (D).", "The voltage corresponding to the complementary logic value is placed on the complementary data line 305-1 (D_) and complementary data line 305-2 (D_).", "Data is shown as being present on the complementary data lines 305-1 because data is transferred from the compute components to the first group of sense amplifiers.", "Data is shown as being present on the complementary data lines 305-2 because data is transferred from the compute components to the second group of sense amplifiers.", "In the pseudo code above, “Trigger EQ signal except where operation is desired” indicates that the equilibration signal (EQ signal shown in FIG.", "3A) corresponding to the first group of sense amplifiers is enabled at t3 as shown in FIG.", "3A.", "Therefore, the complementary data lines 305-1 (D and D_) associated with the first group of sense amplifiers are shorted to VDD/2 and complementary data lines 305-2 (D and D_) associated with the second group of sense amplifiers are not shorted to VDD/2 at t4.In FIG.", "3A, the EQ signal is shown as a solid line between t3 and t4 indicating equilibration of the first group of sense amplifiers, while the EQ signal is shown as a dotted line between t3 and t4 indicating non-equilibration of the second group of sense amplifiers.", "That is, between t3 and t4, the first group of sense amplifiers is equilibrated and the second group of sense amplifiers is not equilibrated.", "Independently controlling equilibration of different groups of sense amplifiers can provide various benefits as described further herein.", "In the example described in association with FIG.", "3A, the data values that were previously stored in the first group of sense amplifiers are lost upon the equilibration of the first group of sense amplifiers, while the data values previously stored in the second group of sense amplifiers are retained (e.g., because the second group of sense amplifiers are not equilibrated at t3).", "After equilibration of the first group of sense amplifiers is disabled at t4 as shown in FIG.", "3A, a selected row to which the plurality of memory cells are coupled is enabled (e.g., by activating a “Row” signal provided to a selected row) as indicated by “Open Row” in the pseudo code and shown at t5 in FIG.", "3A.", "When the Row signal reaches the threshold voltage (Vt) of the access transistors (e.g., 202-4) corresponding to the cells of the selected row, the access transistors turn on and a differential voltage signal is created between the complementary data line pairs (e.g., D/D_) based on the voltage stored on the capacitors (e.g., 203-4).", "In the pseudo code above, “Fire Sense Amplifiers” indicates that the first group of sense amplifiers and the second group of sense amplifiers are activated (e.g., fired) and subsequently deactivated.", "For example, activating the sense amplifiers can include the ACT positive control signal (e.g., 265 shown in FIG.", "2C) going high while the RnIF negative control signal (e.g., 228 shown in FIG.", "2C) goes low, which amplifies the differential signal between complementary data lines 305-1 and 305-2, resulting in data values being “latched” by the sense amplifiers.", "Activating the sense amplifiers while the selected row is enabled results in data being moved via complementary data lines from the second group of sense amplifiers to the second group of memory cells.", "That is, the second group of memory cells that are coupled to sense lines that are also coupled to the second group of sense amplifiers store a copy of the data stored in the second group of sense amplifiers.", "Activating the first group of sense amplifiers while the selected row is enabled results in the data being moved from the first group of memory cells to the first group of sense amplifiers.", "That is, the data stored in the first group of memory cells that are coupled to sense lines that are also coupled to the first group of sense amplifiers is latched in the sense amplifiers.", "The data is latched in the first group of sense amplifiers because the first group of sense amplifiers were equilibrated before the first group of sense amplifiers was activated.", "As such, data from the compute components can be selectively stored in the memory cells coupled to the selected row by moving data from the compute components to the corresponding first group of sense amplifiers and to the corresponding second group of sense amplifiers, by moving data from the second group of sense amplifiers to the second group of memory cells, and by not moving data from the first group of sense amplifiers to the second group of memory cells.", "After the sense amplifiers are activated, the Row signal applied to the selected row is disabled as indicated by “Close Row” in the pseudo code above and as shown at t7 in FIG.", "3A, which can be accomplished by the access transistor turning off to decouple the selected cells from the corresponding data line.", "Once the selected row is closed and the memory cells are isolated from the data lines, the data lines can be precharged as indicated by the “Equilibrate” in the pseudo code above and as shown at t8 in FIG.", "3A (e.g., equilibration is performed on the first and second groups of sense amplifiers as shown at t8).", "A precharge of the data lines can be accomplished by an equilibrate operation, as described above.", "FIG.", "3B is a timing diagram illustrating operation of the sensing circuitry in accordance with a number of embodiments of the present disclosure.", "FIG.", "3B provides an example of selectively modifying a plurality of compute components using data stored in memory cells coupled to a particular row.", "That is, FIG.", "3B provides a number of waveforms and control signals associated with an example of selectively loading data into a plurality of compute components.", "Selectively modifying the plurality of compute components can include modifying data stored in a first group of compute components while maintaining data stored in a second (e.g., different) group of compute components in an unmodified state.", "Although the example shown in FIG.", "3B involves two groups of compute components, embodiments are not limited to two groups of compute components and can include more groups of compute components.", "The first group of compute components corresponds to a first group of columns (e.g., coupled to a first plurality of sense lines or complementary sense line pairs).", "The first group of compute components is coupled to a corresponding first group of sense amplifiers.", "The second group of compute components corresponds to a second group of columns (e.g., coupled to a second plurality of sense lines or complementary sense line pairs) and are coupled to a corresponding second group of sense amplifiers.", "FIG.", "3B illustrates a number of control signals associated with operating sensing circuitry (e.g., 250-2 in FIG.", "2A).", "“EQ” corresponds to an equilibrate signal applied to the sense amplifier 206-2, “FUNCTION” corresponds to signals applied to PASS and/or PASS* gates that are controlled by a logical operation selection logic including the TF, TT, FT, and FF control signals, “ROW” corresponds to an activation signal applied to a selected access line, and “SENSE AMP” corresponds to an activation signal applied to a sense amplifier.", "FIG.", "3B also illustrates the waveform diagrams showing the signals (e.g., voltage signals) on a first group of data lines D and D— (e.g., 305-1) coupled to a first group of sense amplifier and on a second group of data lines D and D— (e.g., 305-2) coupled to a second group of sense amplifiers.", "FIG.", "3B also illustrates the waveform diagrams showing the signals (e.g., voltage signals) on the nodes S and S* corresponding to the compute component (e.g., accumulator) during the selective store operation.", "The particular timing diagram waveforms are discussed below with respect to the pseudo code associated with selectively storing data in memory cells.", "An example of pseudo code associated with selectively loading data in the compute components can be summarized as follows: Deactivate EQ; Open Row; Fire Sense Amplifiers; Trigger EQ signal except where operation is desired; Apply Function Lines; Equilibrate In the pseudo code above, “Deactivate EQ” indicates that an equilibration signal (EQ signal shown in FIG.", "3B) corresponding to a first group of sense amplifiers and a second group of sense amplifiers is disabled at t1 as shown in FIG.", "3B.", "As such, at t1 the voltage on the complementary data lines 305-1 and 305-2 (e.g., D and D_) is VDD/2.A selected row to which the plurality of memory cells are coupled is enabled (e.g., selected, opened such as by activating a signal to select a particular row) as indicated by “Open Row” in the pseudo code and shown at t2 in FIG.", "3B.", "When the ROW signal reaches the threshold voltage (Vt) of the access transistors (e.g., 202-4) corresponding to the cells of the selected row, the access transistors turns on and a differential voltage signal is created between the complementary data line pairs (e.g., D/D_) based on the voltage stored on the capacitors (e.g., 203-4).", "In the pseudo code above, “Fire Sense Amplifiers” indicates that the sense amplifiers are activated (e.g., fired) and subsequently deactivated as shown at t3 and at t5, respectively.", "Activating the sense amplifiers while the ROW that is coupled to the memory cells is enabled results in the data being moved via complementary data lines 305-1 and 305-2 from the memory cells to the sense amplifiers.", "The ACT positive control signal (e.g., 265 shown in FIG.", "2C) going high while the RnIF negative control signal (e.g., 228 shown in FIG.", "2C) goes low, which amplifies the differential signal between complementary data lines 305-1 and 305-2, resulting in data values being “latched” by the sense amplifiers.", "In the pseudo code above, “Trigger EQ signal except where operation is desired” indicates that the equilibration signal (EQ signal shown in FIG.", "3B) corresponding to the first group of sense amplifiers is enabled at t5 as shown in FIG.", "3B.", "Therefore, the complementary data lines 305-1 (D and D_) associated with the first group of sense amplifiers are shorted to VDD/2 and complementary data lines 305-2 (D and D_) associated with the second group of sense amplifiers are not shorted to VDD/2.The complementary data lines 305-1 coupled to the first group of sense amplifiers are shorted to VDD/2.The complementary data lines 305-2 coupled to the second group of sense amplifiers retain a VDD voltage or a GND voltage.", "In FIG.", "3B, the EQ signal is shown as a solid line between t5 and t7 indicating the equilibration of the first group of sense amplifiers, while the EQ signal is shown as a dotted line between t5 and t7 indicating non-equilibration of the second group of sense amplifiers.", "In FIG.", "3B, the activation signal applied to “SENSE AMP” is shown as a solid line between t5 and t7 indicating the deactivation of the first group of sense amplifiers due to the equilibration of the first group of sense amplifiers, while the activation signal applied to the “SENSE AMP” is shown as a solid line between t5 and t7 indicating the activation of the second group of sense amplifiers due to the non-equilibration of the second group of sense amplifiers.", "The data that was previously stored in the first group of sense amplifiers is lost upon the equilibration of the first group of sense amplifiers.", "“Apply function lines” as shown in the above pseudocode can refer to activating appropriate control signals coupled to the sense amplifiers to perform a selected operation.", "As shown in FIG.", "3B, at t6 the function signal is activated indicating activation of appropriate control signals corresponding to a selected operation.", "Applying the function lines can also include transferring data between the sense amplifiers and the compute components.", "For example, data can be transferred from the first group of compute components to the first group of sense amplifiers due to the first group of sense amplifiers being in an equilibrated state.", "Transferring data from the first group of compute components to the first group of sense amplifiers can include not modifying the data stored in the first group of compute components.", "Data can be transferred from the second group of sense amplifiers to the second group of compute components due to the second group of the sense amplifiers being in an activated state.", "The data stored in the sense amplifiers can be selectively loaded into the compute components due to the data stored on the second group of sense amplifiers being moved to the second number of compute components without updating the data stored in the first group of compute components.", "S and S* are shown as fluctuating at t7 to represent the loading of data into the second group of compute components and the retaining of data into the first group of compute components.", "Once the function lines are deactivated, the data lines can be precharged as indicated by the “Equilibrate” in the pseudo code above and as shown at t7 in FIG.", "3B.", "A precharge of the data lines can be accomplished by an equilibrate operation, as described above.", "FIG.", "3C is a timing diagram illustrating operation of the sensing circuitry in accordance with a number of embodiments of the present disclosure.", "FIG.", "3C provides an example of selectively copying data from memory cells coupled to a first access line to memory cells coupled to a second access line.", "Selectively copying data from a first plurality of memory cells coupled to the first access line to a second plurality of memory cells coupled to the second access line can include copying data stored in a first group of memory cells from the first plurality of memory cells to a first group of memory cells from the second plurality of memory cells and not copying data stored in a second group of memory cells from the first plurality of memory cells and to a second group of memory cells from the second plurality of memory cells.", "In FIG.", "3C, there are two groups of memory cells in each of the first plurality of memory cells coupled to the first row and the second plurality of memory cells coupled to the second row.", "However, examples are not limited to two groups of memory cells and can include more groups of memory cells in each of the first plurality of memory cells and the second plurality of memory cells.", "The first plurality of memory cells and the second plurality of memory cells are coupled to a plurality of sense lines.", "For example, a first memory cell in the first plurality of memory cells and a first memory cell in the second plurality of memory cells can be coupled to a first sense line, a second memory cell in the first plurality of memory cells and a second memory cell in the second plurality of memory cells can be coupled to a second sense line, .", ".", ".", ", an (N−1) memory cell in the first plurality of memory cells and an (N−1) memory cell in the second plurality of memory cells can be coupled to an (N−1) sense line.", "The sense lines that are coupled to the first plurality of memory cells and the second plurality of memory cells can be coupled to a plurality of sense amplifiers.", "FIG.", "3C illustrates a number of control signals associated with operating sensing circuitry (e.g., 250-2 in FIG.", "2A).", "“EQ” corresponds to an equilibrate signal applied to the sense amplifier 206-2 (e.g., via an equilibrate control line), “ROW 1” corresponds to an activation signal applied to a first access line, “ROW 2” corresponds to an activation signal applied to a second access line, “SENSE AMP” corresponds to activation signal applied to a sense amplifier.", "FIG.", "3C also illustrates the waveform diagrams showing the signals (e.g., voltage signals) on a first group of data lines D and D— (e.g., 305-1) coupled to a first group of sense amplifier from the plurality of sense amplifiers and on a second group of data lines D and D— (e.g., 305-2) coupled to a second group of sense amplifiers from the plurality of sense amplifiers.", "The particular timing diagram waveforms are discussed below with respect to the pseudo code associated with selectively storing data in memory cells.", "An example of pseudo code associated with selectively loading data in the compute components can be summarized as follows: Deactivate EQ; Open Row1; Fire Sense Amplifiers; Trigger EQ signal except where operation is desired; Open Row2; Fire Sense Amplifiers; Equilibrate; In the pseudo code above, “Deactivate EQ” indicates that an equilibration signal (EQ signal shown in FIG.", "3C) corresponding to a first group of sense amplifiers and a second group of sense amplifiers is disabled at t1 as shown in FIG.", "3C.", "As such, at t1 the voltage on the complementary data lines 305-1 and 305-2 (e.g., D and D_) is VDD/2.A selected access line to which the first plurality of memory cells are coupled is enabled (e.g., by activating a “ROW1” signal provided to a select row) as indicated by “Open Row1” in the pseudo code and shown at t2 in FIG.", "3C.", "When the ROW signal reaches the threshold voltage (Vt) of the access transistors (e.g., 202-4) corresponding to the cells of the selected row, the access transistors turns on and a differential voltage signal is created between the complementary data line pairs (e.g., D/D_) based on the voltage stored on the capacitors (e.g., 203-4).", "The selected row is subsequently disabled as shown at t4.In the pseudo code above, “Fire Sense Amplifiers” indicates that the sense amplifiers are activated (e.g., fired) and subsequently deactivated as shown at t3 and at t5 in FIG.", "3C.", "Activating the sense amplifiers while the selected row (e.g., ROW1) is enabled results in the data being moved via complementary data lines 305-1 and 305-2 from the first plurality of memory cells to the sense amplifiers.", "The ACT positive control signal (e.g., 265 shown in FIG.", "2C) going high while the RnIF negative control signal (e.g., 228 shown in FIG.", "2C) goes low, which amplifies the differential signal between complementary data lines 305-1 and 305-2, resulting in data values being “latched” by the sense amplifiers.", "In the pseudo code above, “Trigger EQ signal except where operation is desired” indicates that the equilibration signal (EQ signal shown in FIG.", "3C) corresponding to the first group of sense amplifiers is enabled at t5 and subsequently disabled at t6 as shown in FIG.", "3C.", "Therefore, the complementary data lines 305-1 (D and D_) associated with the first group of sense amplifiers are shorted to VDD/2 and complementary data lines 305-2 (D and D_) associated with the second group of sense amplifiers are not shorted to VDD/2.The complementary data lines 305-1 are coupled to the first group of memory cells from the first plurality of memory cells and the second plurality of memory cells.", "The complementary data lines 305-2 are coupled to the second group of memory cells from the first plurality of memory cells and the second plurality of memory cells.", "The complementary data lines 305-1 coupled to a first group of sense amplifiers are shorted to VDD/2.The complementary data lines 305-2 coupled to a second group of sense amplifiers retain a VDD voltage or a GND voltage.", "In FIG.", "3C, the EQ signal is shown as a solid line between t5 and t6 indicating the equilibration of the first group of sense amplifiers, while the EQ signal is shown as a dotted line between t5 and t6 indicating non-equilibration of the second group of sense amplifiers.", "The data that was previously stored in the first group of sense amplifiers is lost upon the equilibration of the first group of sense amplifiers.", "A selected row (e.g., Row2) to which the second plurality of memory cells are coupled is enabled (e.g., selected, opened such as by activating a signal to select a particular row) as indicated by “Open Row2” in the pseudo code and shown at t7 in FIG.", "3C.", "When the ROW signal reaches the threshold voltage (Vt) of the access transistors (e.g., 202-4) corresponding to the cells of the selected row, the access transistors turns on a differential voltage signal is created between the complementary data lines pairs (e.g., D/D_) based on the voltage stored on the capacitors (e.g., 203-4).", "The selected row is subsequently disabled as shown at t9.In the pseudo code above, “Fire Sense Amplifiers” indicates that the sense amplifiers are activated (e.g., fired) and subsequently deactivated as shown at t8 and at t10, respectively.", "Activating the sense amplifiers while the ROW2 is enabled results in data being moved via complementary data lines 305-2 from the second plurality of sense amplifiers to the second group of memory cells from the second plurality of memory cells.", "The ACT positive control signal (e.g., 265 shown in FIG.", "2C) going high while the RnIF negative control signal (e.g., 228 shown in FIG.", "2C) goes low, which amplifies the differential signal between complementary data lines 305-2, resulting in data values being “latched” by the sense amplifiers.", "Data is not transferred from the first plurality of sense amplifiers to the first group of the second plurality of memory cells because the first plurality of sense amplifiers are in an equilibrated state before the sense amplifiers are activated.", "As such, data is selectively copied from the first plurality of memory cells to the second plurality of memory cells.", "That is, data stored in the second group of the first plurality of memory cells is copied to the second group of the second plurality of memory cells while data stored in the first group of the first plurality of memory cells is not copied to the first group of the second plurality of memory cells.", "Once the function lines are deactivated, the data lines can be precharged as indicated by the “Equilibrate” in the pseudo code above and as shown at t10 in FIG.", "3C.", "A precharge of the data lines can be accomplished by an equilibrate operation, as described above.", "FIG.", "3D is a timing diagram illustrating operation of the sensing circuitry in accordance with a number of embodiments of the present disclosure.", "FIG.", "3D provides an example of selectively generating patterns of zeros and ones.", "The generated pattern can be stored in a plurality of compute components.", "The generated pattern can include blocks of 1-bits and 0-bits.", "In this example, a block of bits includes a plurality of bits stored in continuous compute components.", "In FIG.", "3D, a pattern includes two blocks of bits.", "However, examples are not limited to patterns including two blocks of bits and can include patterns including more than two blocks of bits.", "The first block of bits can be a block of 1-bits.", "The second block of bits can be a block of 0-bits.", "The first block of bits can be stored in a first group of compute components that are coupled to complementary data lines 305-1 and to a first group of sense amplifiers.", "The second block of bits can be stored in a second group of compute components that are coupled to complementary data lines 305-2 and to a second group of sense amplifiers.", "FIG.", "3D illustrates a number of control signals associated with operating sensing circuitry (e.g., 250-2 in FIG.", "2A).", "“EQ” corresponds to an equilibrate signal applied to the sense amplifier 206-2 (e.g., via an equilibrated control line), “FUNCTION” corresponds to signals applied to PASS and/or PASS* gates that are controlled by a logical operation selection logic including the TF, TT, FT, and FF control signals, “ROW” corresponds to an activation signal applied to an access line, “SENSE AMP” corresponds to activation signal applied to a sense amplifier.", "FIG.", "3D also illustrates the waveform diagrams showing the signals (e.g., voltage signals) on a first group of data lines D and D— (e.g., 305-1) coupled to a first group of sense amplifier and first group of compute components and on a second group of data lines D and D— (e.g., 305-2) coupled to a second group of sense amplifiers and a second group of compute components.", "FIG.", "3D also illustrates the waveform diagrams showing the signals (e.g., voltage signals) on the nodes S and S* corresponding to the compute components (e.g., accumulator) during the creation of the pattern.", "The particular timing diagram waveforms are discussed below with respect to the pseudo code associated with creating a pattern of 0-bits and 1-bits.", "An example of pseudo code associated with selectively loading data in the compute components can be summarized as follows: Deactivate EQ; Clear Sense Amplifiers; Trigger EQ signal for blocks that should be set; Apply set/XNOR function signals; Copy from sense amplifiers to the accumulator; Equilibrate; In the pseudo code above, “Deactivate EQ” indicates that an equilibration signal (EQ signal shown in FIG.", "3D) corresponding to a first group of sense amplifiers and a second group of sense amplifiers is disabled at t1 as shown in FIG.", "3D.", "As such, at t1 the voltage on the complementary data lines 305-1 and 305-2 (e.g., D and D_) is VDD/2.In the pseudo code above, “Clear Sense Amplifiers” indicates that the sense amplifiers can store 0-bits.", "The sense amplifiers can be cleared by activating the function lines as shown at t2 in FIG.", "3D and activating the sense amplifiers as shown at t3 to create 0-bits and store the 0-bits in the sense amplifiers.", "The function lines and the sense amplifiers can be deactivated at t4.A reset operation can be performed via the function lines to create a voltage (e.g., GND) corresponding to a logic 0 being on data line 305-1 (D) and data line 305-2 (D).", "The sense amplifiers can be activated to latch the 0-bits.", "In the pseudo code above, “Trigger EQ signal for blocks that should be set” indicates that the equilibration signal (EQ signal shown in FIG.", "3D) corresponding to the first group of sense amplifiers is enabled at t5 and disabled at t6 as shown in FIG.", "3D.", "Therefore, the complementary data lines 305-1 (D and D_) associated with the first group of sense amplifiers are shorted to VDD/2 and complementary data lines 305-2 (D and D_) associated with the second group of sense amplifiers are not shorted to VDD/2.The complementary data lines 305-1 coupled to the first group of sense amplifiers are shorted to VDD/2.The complementary data lines 305-2 coupled to the second group of sense amplifiers retain a GND voltage.", "FIG.", "3D shows the enablement of the equilibration signal (e.g., EQ) on a first group of sense amplifiers as a solid line at t5.In FIG.", "3D, the EQ signal is shown as a solid line between t5 and t6 indicating the equilibration of the first group of sense amplifiers, while the EQ signal is shown as a dotted line between t5 and t6 indicating non-equilibration of the second group of sense amplifiers.", "The data that was previously stored in the first group of sense amplifiers is lost upon the equilibration of the first group of sense amplifiers.", "In the pseudo code above, “Apply set/XNOR function signals” indicates that the function lines can be activated to select a set/XNOR operation as shown at t7 in FIG.", "3D.", "The function lines can be subsequently be deactivated as shown at t9.Applying the function lines to select a set/XNOR operation can include applying the function lines to perform a set operation, storing the results in the sense amplifiers, performing an XNOR operation, and storing the results in the compute components concurrently.", "As such, the function lines can be activated to create a voltage (e.g., VDD) corresponding to a logic 1 being on data line 305-1 (D) and a voltage (e.g., GND) corresponding to a logic 0 being on data line 305-2 (D).", "The sense amplifiers can be activated as shown at t5 in FIG.", "3D to store the 1-bits in first group of sense amplifiers coupled to the complementary data lines 305-1 and to store the 0-bits in the second group of sense amplifiers coupled to the complementary data lines 305-2.In the pseudo code above, “Copy from sense amplifiers to the accumulator” indicates that the function lines can be activated while the sense lines are active as shown at t10 in FIG.", "3D.", "The function lines can be activated to select a copy operation and to transfer data from the sense amplifiers to the compute components.", "S and S* are shown as fluctuating at t10 to represent the storing of data into the compute components.", "As such, the compute components can store 1-bits in a first block of compute components and 0-bits in a second block of compute components.", "Once the function lines and the sense amplifiers are deactivated as shown at t11, the data lines can be precharged as indicated by the “Equilibrate” in the pseudo code above and as shown at t12 in FIG.", "3D.", "A precharge of the data lines can be accomplished by an equilibrate operation, as described above.", "FIG.", "3E is a timing diagram illustrating operation of the sensing circuitry in accordance with a number of embodiments of the present disclosure.", "FIG.", "3E provides an example of selectively loading data into the compute components and storing the data in to the memory cells concurrently.", "That is, FIG.", "3E provides an example of selectively loading data previously stored in the memory cells into a plurality of compute components and storing the selectively loaded data into the memory cells.", "Selectively modifying the plurality of compute components includes modifying data stored in a first group of compute components and retaining (e.g., not modifying) data stored in a second group of compute components.", "In FIG.", "3E, there are two groups of compute components.", "However, examples are not limited to two groups of compute components and can include more groups of compute components.", "A first group of compute components is modified and a second group of compute components is not modified.", "The first group of compute components is coupled to a first plurality of sense lines.", "The first plurality of sense lines are coupled to a first group of sense amplifiers and associated memory cells.", "The second group of compute components is coupled to a second plurality of sense lines.", "The second plurality of sense lines is coupled to a second group of sense amplifiers and associated memory cells.", "FIG.", "3E illustrates a number of control signals associated with operating sensing circuitry (e.g., 250-2 in FIG.", "2A).", "“EQ” corresponds to an equilibrate signal applied to the sense amplifier 206-2 (e.g., via an equilibrate control line), “FUNCTION” corresponds to signals applied to a PASS and/or PASS* gates that are controlled by a logical operation selection logic including the TF, TT, FT, and FF control signals, “ROW” corresponds to an activation signal applied to an access line, “SENSE AMP” corresponds to activation signal applied to a sense amplifier.", "FIG.", "3E also illustrates the waveform diagrams showing the signals (e.g., voltage signals) on a first group of data lines D and D— (e.g., 305-1) coupled to a first group of sense amplifier and on a second group of data lines D and D— (e.g., 305-2) coupled to a second group of sense amplifiers.", "FIG.", "3E also illustrates the waveform diagrams showing the signals (e.g., voltage signals) on the nodes S and S* corresponding to the compute component (e.g., accumulator) during the selective store operation.", "The particular timing diagram waveforms are discussed below with respect to the pseudo code associated with selectively storing data in memory cells.", "An example of pseudo code associated with selectively loading (e.g., storing) data in the compute components can be summarized as follows: Deactivate EQ; Open Row; Fire Sense Amplifiers except where a store is desired; Apply Function Lines; Fire remaining Sense Amplifiers; Close Row; Equilibrate; In the pseudo code above, “Deactivate EQ” indicates that an equilibration signal (EQ signal shown in FIG.", "3E) corresponding to a first group of sense amplifiers and a second group of sense amplifiers is disabled at t1 as shown in FIG.", "3E.", "As such, at t1 the voltage on the complementary data lines 305-1 and 305-2 (e.g., D and D_) is VDD/2.A selected access line to which the plurality of memory cells are coupled is enabled (e.g., by activating a “ROW” signal provided to select row) as indicated by “Open Row” in the pseudo code and shown at t2 in FIG.", "3E.", "When the ROW signal reaches the threshold voltage (Vt) of the access transistors (e.g., 202-4) corresponding to cells of the selected row, the access transistors turns on and a differential voltage signal is created between the complementary data line pairs (e.g., D/D_) based on the voltage stored on the capacitors (e.g., 203-4).", "In the pseudo code above, “Fire Sense Amplifiers except where a store is desired” indicates that the first group of sense amplifiers are activated (e.g., fired) as shown at t3.Activating the sense amplifiers while the selected row (e.g., ROW) is enabled results in the data being moved via complementary data lines 305-1 from the first group of memory cells to the first group of sense amplifiers.", "The ACT positive control signal (e.g., 265 shown in FIG.", "2C) going high while the RnIF negative control signal (e.g., 228 shown in FIG.", "2C) goes low, which amplifies the differential signal between complementary data lines 305-1, resulting in data values being “latched” by the sense amplifiers.", "The second group of sense amplifiers continues in an equilibrated state.", "The function lines coupled to the sense amplifiers can be activated and deactivated (e.g., selected, opened such as by activating a signal to select a particular function line) as indicated by “Apply Function lines” in the pseudo code and shown at t4 and t6 for FUNCTION in FIG.", "3E.", "Applying the function lines can include transferring data between the sense amplifiers and the compute components.", "For example, data can be transferred from the second group of compute components to the second group of sense amplifiers due to the second group of sense amplifiers being in an equilibrated state.", "Transferring data from the second group of compute components to the second group of sense amplifiers can include not modifying the data stored in the second group of compute components.", "Data can be transferred from the first group of sense amplifiers to the first group of sense amplifiers due to the first group of the sense amplifiers being in an activated state.", "The data stored in the sense amplifiers can be selectively loaded into the compute components due to the data stored in the second group of sense amplifiers being moved to the second number of compute components without updating the data stored in the first group of compute components.", "S and S* are shown as fluctuating at t4 to represent the loading of data into the second group of compute components and not loading of data into the first group of compute components.", "After the function lines are activated, in the pseudo code above, “Fire remaining Sense Amplifiers” indicates that the first group of sense amplifiers are activated (e.g., fired) as shown at t5.Activating the sense amplifiers that were not activated at t3 as the selected row (e.g., ROW) is enabled and the function lines are enabled results in data being moved via complementary data lines 305-1 from first group of sense amplifiers to the first group of compute components and from the first group of sense amplifiers to the first group of memory cells.", "The data that is moved from the first group of sense amplifiers to the first group of compute components at t5 is the same data that was moved from the first group of compute components to the first group of sense amplifiers at t4.As such, moving data from the first group of sense amplifiers to the first group of compute components includes the first group of compute components retaining the data stored in the first group of compute components because the data in the first group of compute components does not change.", "The function lines can be disabled at t6.The ROW can be disabled at t7.The sense amplifiers can be deactivated at t8.The data lines can be precharged as indicated by the “Equilibrate” in the pseudo code above and as shown at t8 in FIG.", "3E.", "A precharge of the data lines can be accomplished by an equilibrate operation, as described above.", "According to various embodiments, general computing can be enabled in a memory array core of a processor-in-memory (PIM) device such as a DRAM one transistor per memory cell (e.g., 1T1C) configuration at 6F̂2 or 4F̂2 memory cell sizes, for example.", "One potential advantage of the apparatuses and methods described herein is not realized in terms of single instruction speed, but rather the cumulative speed that can be achieved by an entire bank of data being computed in parallel without necessarily transferring data out of the memory array (e.g., DRAM) or firing a column decode.", "For example, data transfer time can be reduced and/or eliminated.", "Also, a number of apparatuses of the present disclosure can perform ANDS or ORs in parallel, e.g., concurrently, using data values in memory cells coupled to a data line (e.g., a column of 16K memory cells).", "In previous approach sensing circuits where data is moved out for logical operation processing (e.g., using 32 or 64 bit registers), fewer operations can be performed in parallel compared to the apparatus of the present disclosure.", "In this manner, significantly higher throughput is effectively provided in contrast to conventional configurations involving an off pitch processing unit discrete from the memory such that data must be transferred there between.", "An apparatus and/or methods according to the present disclosure can also use less energy/area than configurations where the logical operation is discrete from the memory.", "Furthermore, an apparatus and/or methods of the present disclosure can provide additional energy/area advantages since the in-memory-array logical operations eliminate certain data value transfers." ] ]
Patent_15874117
[ [ "SOFT TISSUE FIXATION SYSTEM", "A soft tissue fixation assembly includes a plurality of deformable bone anchors and a suture that is configured to fixedly attach to each of the bone anchors.", "One or more of the bone anchors can be inserted into a bone, and one or more of the bone anchors can be inserted through soft tissue and into the bone.", "The suture can be inserted through the bone anchors, and energy can be applied to the anchors, thereby causing a deformable material of the bone anchors to deform, thereby capturing the strand of suture in the bone anchor.", "The strand of suture can be placed in tension, and can extend over the soft tissue so as to retain the soft tissue in contact with the bone." ], [ "1.A bone anchor configured to deform in response to an applied energy from a laser source, the bone anchor comprising: a bone anchor body having (1) a proximal end, (2) a distal end that is spaced from the proximal end along a central longitudinal axis, and (3) a perimeter surface that extends from the proximal end to the distal end, the bone anchor body defining at least one channel that extends into the perimeter surface and that is elongate as it extends between the proximal end and the distal end, wherein at least a portion of the bone anchor body comprises a deformation material that defines at least a portion of the perimeter surface and the at least one channel, the deformation material being responsive to the applied energy from the laser source so as to deform and capture a strand of suture with respect to movement relative to the bone anchor body when the strand of suture is received by the at least one channel, and the deformation material is configured to prevent the applied energy from the laser source from traveling to the distal end.", "2.The bone anchor of claim 1, wherein the at least one channel comprises first and second channels that extend into the perimeter surface, each being elongate as it extends between the proximal end and the distal end.", "3.The bone anchor of claim 2, wherein the first and second channels are spaced opposite one another.", "4.The bone anchor of claim 2, wherein the first and second channels are offset from one another other by an angle of separation of substantially 90 degrees.", "5.The bone anchor of claim 2, wherein the first and second channels are configured to receive first and second portions, respectively, of the strand of suture, wherein the deformation material is responsive to the applied energy so as to deform and, when the first and second portions of the strand of suture are received in the first and second channels, respectively, close at least a portion of each of the first and second channels and capture the first and second portions of the strand of suture therein with respect to movement relative to the bone anchor body.", "6.The bone anchor of claim 2, wherein each of the first and second channels defines a first end, and a second end that is distal from the first end, and the second ends of the first and second channels are open to each other.", "7.The bone anchor of claim 6, wherein the second ends are open to each other at the distal end of the bone anchor body.", "8.The bone anchor of claim 1, wherein the bone anchor defines a color configured to prevent a laser beam from the laser from traveling to the distal end.", "9.The bone anchor of claim 1, wherein the bone anchor is made of a substance that prevents the applied energy from traveling to the distal end.", "10.The bone anchor of claim 1, wherein the deformation material is disposed in a middle region of the anchor body that includes a location midway between the proximal and distal ends.", "11.The bone anchor of claim 1, wherein the bone anchor has an internal surface that defines an aperture that extends into the proximal end substantially along the central longitudinal axis, and the internal surface is configured to receive a light pipe extending from the laser source.", "12.A soft tissue fixation system comprising: the bone anchor of claim 11; and a laser instrument including the laser source and the light pipe extending from the laser source, the light pipe configured to be received in the aperture of the bone anchor and configured to carry a laser beam emitted by the laser source, and apply the laser beam to the bone anchor.", "13.A method of anchoring suture to at least one bone, the method comprising steps of: inserting at least a portion of a strand of suture into at least one channel that extends into an outer perimeter surface of a bone anchor and that is elongate a proximal direction that extends from a distal end of the bone anchor to a proximal end of the bone anchor such that the portion of the strand of suture extends along the at least one channel in the proximal direction and out the proximal end of the bone anchor; driving the distal end of the bone anchor into the at least one bone in a distal direction, opposite the proximal direction; applying energy from a laser source to the bone anchor such that the energy causes a deformation material that defines at least a portion of the at least one channel to deform and capture the portion of the strand of suture with respect to movement relative to the bone anchor, and such that the deformation material prevents the energy from the laser source from traveling to the distal end.", "14.The method of claim 13, wherein the at least one channel comprises first and second channels, and the inserting step comprises inserting at least first and second portions of the strand of suture into the first and second channels, respectively, such that the first and second portions extend along the first and second channels, respectively, in the proximal direction and out the proximal end of the bone anchor.", "15.The method of claim 14, wherein the inserting step comprises routing a portion of the suture from the first channel to the second channel, the first and second channels being spaced opposite one another.", "16.The method of claim 14, wherein the inserting step comprises routing a portion of the suture from the first channel to the second channel, the first and second channels being offset from one other by an angle of separation of substantially 90 degrees.", "17.The method of claim 13, wherein the applying step comprises applying the energy such that a color defined by the bone anchor prevents the energy from the laser source from traveling to the distal end.", "18.The method of claim 13, wherein the applying step comprises applying the energy such that a substance that forms the bone anchor prevents the applied energy from traveling to the distal end.", "19.The method of claim 13, comprising inserting a light pipe that extends from the laser source into an aperture that extends into the proximal end of the bone anchor, and the applying energy step comprises causing the laser source to emit a laser beam along the light pipe to the bone anchor.", "20.The method of claim 13, wherein the applying step comprises causing the distal end of the bone anchor to be drawn towards the proximal end of the bone anchor as the deformation material deforms, thereby shortening an overall length of the bone anchor from its distal end to its proximal end." ], [ "<SOH> BACKGROUND <EOH>Common injuries can involve tears of soft tissue, such as tendons and ligaments, and detachments of soft tissue from one or more underlying bones.", "As one example, the tendons at the ends of the rotator cuff muscles can become torn, leading to pain and restricted movement of the musculoskeletal system.", "The soft tissue can be conventionally re-attached to bone arthroscopically, for instance by driving bone anchors into the bone at a desired locations, and attaching separate strands of suture to each of the bone anchors and the soft tissue.", "Each of the separate strands of suture is then tied off to draw the soft tissue against the bone, thereby allowing reattachment of the soft tissue to the bone.", "What is desired is an improved method and apparatus for attaching soft tissue to bone." ], [ "<SOH> SUMMARY <EOH>In accordance with one embodiment, a bone anchor includes a bone anchor body defining a proximal end, a distal end that is spaced from the proximal end along a longitudinal axis, and a perimeter that extends between the proximal end and the distal end.", "The bone anchor body is configured to receive a strand of suture.", "At least a portion of the bone anchor body comprises a deformation material that is responsive to an applied energy so as to deform and, when the strand of suture is received by the anchor body, capture the strand of suture with respect to movement relative to the bone anchor body." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This is a continuation of U.S. patent application Ser.", "No.", "13/832,201, filed Mar.", "15, 2013, which is a continuation-in-part of U.S. patent application Ser.", "No.", "13/800,868, filed Mar.", "13, 2013, the disclosures of both of which are hereby incorporated by reference as if set forth in their entirety herein.", "This claims the benefit of U.S. patent application Ser.", "No.", "61/780,077 filed Mar.", "13, 2013, the disclosure of which is hereby incorporated by reference as if set forth in its entirety herein.", "BACKGROUND Common injuries can involve tears of soft tissue, such as tendons and ligaments, and detachments of soft tissue from one or more underlying bones.", "As one example, the tendons at the ends of the rotator cuff muscles can become torn, leading to pain and restricted movement of the musculoskeletal system.", "The soft tissue can be conventionally re-attached to bone arthroscopically, for instance by driving bone anchors into the bone at a desired locations, and attaching separate strands of suture to each of the bone anchors and the soft tissue.", "Each of the separate strands of suture is then tied off to draw the soft tissue against the bone, thereby allowing reattachment of the soft tissue to the bone.", "What is desired is an improved method and apparatus for attaching soft tissue to bone.", "SUMMARY In accordance with one embodiment, a bone anchor includes a bone anchor body defining a proximal end, a distal end that is spaced from the proximal end along a longitudinal axis, and a perimeter that extends between the proximal end and the distal end.", "The bone anchor body is configured to receive a strand of suture.", "At least a portion of the bone anchor body comprises a deformation material that is responsive to an applied energy so as to deform and, when the strand of suture is received by the anchor body, capture the strand of suture with respect to movement relative to the bone anchor body.", "BRIEF DESCRIPTION OF THE DRAWINGS The foregoing summary, as well as the following detailed description of an example embodiment of the application, will be better understood when read in conjunction with the appended drawings, in which there is shown in the drawings example embodiments for the purposes of illustration.", "It should be understood, however, that the application is not limited to the precise arrangements and instrumentalities shown.", "In the drawings: FIG.", "1 is a schematic top plan view of a soft tissue fixation assembly anchored to bone and retaining a soft tissue against the bone, the soft tissue fixation assembly constructed in accordance with one embodiment.", "FIG.", "2A is a perspective view of a bone anchor of the soft tissue fixation assembly illustrated in FIG.", "1, showing the bone anchor in accordance with one embodiment; FIG.", "2B is a side elevation view of the bone anchor illustrated in FIG.", "2A; FIG.", "2C is a sectional side elevation view of the bone anchor illustrated in FIG.", "2A; FIG.", "2D is a bottom plan view of the bone anchor illustrated in FIG.", "2A; FIG.", "2E is a top plan view of the bone anchor illustrated in FIG.", "2A; FIG.", "3A is a perspective view of a bone anchor constructed in accordance with an alternative embodiment; FIG.", "3B is a sectional side elevation view of the bone anchor illustrated in FIG.", "3A; FIG.", "3C is an exploded perspective view of the bone anchor illustrated in FIG.", "3A; FIG.", "4A is a perspective view of a suture extending through opposed channels of the bone fixation element illustrated in FIG.", "2A; FIG.", "4B is a perspective view of a suture extending through adjacent channels of the bone fixation element illustrated in FIG.", "2A; FIG.", "5A is a schematic sectional side elevation view of a soft tissue fixation system constructed, including an actuation assembly shown operably engaged with an initial bone anchor of the soft tissue fixation assembly illustrated in FIG.", "1; FIG.", "5B is a schematic sectional side elevation view of the soft tissue fixation system illustrated in FIG.", "5A, shown after activation of the actuation assembly; FIG.", "5C is a schematic side elevation view of a soft tissue fixation system illustrated in FIG.", "5B, showing the actuation assembly operably engaged with a subsequent bone anchor of the soft tissue fixation assembly illustrated in FIG.", "1; FIG.", "5D is a schematic sectional side elevation view of the soft tissue fixation system illustrated in FIG.", "5C, shown after activation of the actuation assembly; FIG.", "6A is a schematic sectional side elevation view of a portion of the bone fixation assembly 1, showing a single strand of suture sequentially connected continuously to a plurality of the bone anchors; FIG.", "6B is a schematic sectional side elevation view of a portion of the bone fixation assembly 1, showing a pair of strands of suture each sequentially connected continuously to a plurality of the bone anchors; FIG.", "6C is a schematic sectional side elevation view of a portion of the bone fixation assembly 1, showing the pair of strands of suture each sequentially connected continuously to a plurality of the bone anchors, one of the strands of suture configured to attach to an auxiliary implant; FIG.", "7A is a schematic plan view of the soft tissue fixation assembly as illustrated in FIG.", "1, but showing the bone anchors in one arrangement; FIG.", "7B is a schematic plan view of the soft tissue fixation assembly as illustrated in FIG.", "7A, but showing the bone anchors in another arrangement as illustrated in FIG.", "1, shown as an open arrangement; FIG.", "7C is a schematic plan view of the soft tissue fixation assembly as illustrated in FIG.", "7B, but showing the bone anchors in a closed arrangement in accordance with one embodiment; FIG.", "7D is a schematic plan view of the soft tissue fixation assembly as illustrated in FIG.", "7C, but showing the bone anchors in a closed arrangement in accordance with another embodiment; and FIG.", "7E is a schematic plan view of the soft tissue fixation assembly as illustrated in FIG.", "7B, but showing the bone anchors in an open arrangement in accordance with another embodiment.", "DETAILED DESCRIPTION Referring initially to FIGS.", "1 and 8B, a soft tissue fixation assembly 20 is configured to secure a soft tissue 22 against a surface of an underlying bone 24 so as to promote attachment of the soft tissue 22 to the bone 24.The soft tissue 22 can be detached from the bone due to an anatomical defect, trauma, or the like, and can be configured as any anatomical soft tissue in the human or other animal body, such as a tendon or ligament.", "For instance, in accordance with one embodiment, the tendon can be a rotator cuff tendon or any other tendon as desired.", "The fixation assembly 20 can include at least one bone anchor 26, such as first and second bone anchors 26a and 26b, respectively, and a strand of suture 28 that is configured to attach to each of the bone anchors 26a and 26b.", "For instance, the strand of suture 28 is configured to be received by each of the bone anchors 26 and 26b.", "The first bone and second bone anchors 26a and 26b can, for instance, be driven into the bone 24, such that the strand of suture 28 extends from the first bone anchor 26a to the second bone anchor 26b.", "One of the first and second bone anchors 26a and 26b, for instance the second bone anchor 26b as illustrated, can be driven through the soft tissue 22 and into the bone 24, referred to as a trans-tendon technique.", "The other of the first and second bone anchors 26a and 26b, for instance the first one anchor 26a as illustrated, can be driven into the bone 24 at a location spaced from the soft tissue 22.Thus, the strand of suture 28 can extend from the first bone anchor 26a along an outer surface of the bone 24, across an interface 30 between the bone 24 and the soft tissue 22, to the second bone anchor 26b.", "The strand of suture 28 can be under tension between the first and second bone anchors 26a and 26b so as to apply a force against the soft tissue soft 22 toward the bone 24, thereby causing the soft tissue 22 to maintain contact with the bone 24.It should be recognized that in most instances it may not be recommended, during rotator cuff repair, to insert the bone anchors 26 in the intraarticular space of the shoulder, but rather to position the bone anchors about the joint.", "It will be appreciated from the description below that the fixation assembly 20 can include any number of bone anchors 26, such as a plurality of bone anchors 26, as desired.", "One or more of the plurality of bone anchors 26 can be driven through the soft tissue 22 and into the bone 24.One or more others of the plurality of bone anchors can be driven into the bone 24 at a location spaced from the soft tissue 22, so as to define any geometric pattern as desired.", "In accordance with one embodiment as illustrated in FIG.", "1, the soft tissue fixation assembly 20 can include a third bone anchor 26a driven through the soft tissue 22 and the bone 24, and a fourth bone anchor 26d driven through the bone 24 at a location spaced from both the soft tissue 22 and the first bone anchor 26a.", "The strand of suture 28 can extend continuously from each of the plurality of bone anchors 26 to at least one adjacent one of the plurality of bone anchors 26.Thus, the plurality of bone anchors 26 can define at least one row 32, such as a first row 32a that can be defined by at least some of the plurality of bone anchors 26, and a second row 32b that can be defined by at least others of the plurality of bone anchors 26, the strand of suture 28 connected between the first and second rows 32a and 32b.", "The rows 32a and 32b can extend substantially linearly, curvilinearly, or can define any other suitable arrangement, and can be parallel with each other or aligned to intersect each other as desired.", "The fixation assembly 20 can define as many rows as desired.", "Referring now to FIGS.", "2A-2E, each of the bone anchors 26 can include an anchor body 34 that defines a proximal end 36a and a distal end 36b that is spaced from the proximal end 36a along a distal direction of insertion into bone.", "It should be appreciated that the term “distal” and derivatives thereof can refer to a direction from the proximal end 36a to the distal end 36b, and the term “proximal” and derivatives thereof can refer to a direction from the distal end 36b to the proximal end 36a.", "The anchor body 34 can extend, for instance can be elongate, along a longitudinal axis 38, such that the proximal end 36 and distal end 36b are spaced from each other along the longitudinal axis 38.The longitudinal axis 38 can be substantially straight, or can be curved or assume any alternative shape as desired.", "The anchor body 34 can further define an outer perimeter 40 extends between the proximal end 36a and the distal end 36b.", "The perimeter 40 can be round, for instance substantially circular, as illustrated, or can define any alternative shape whatsoever, such as a rectilinear shape.", "The distal end 36b can define a tip 37 that can be tapered inwardly, and thus toward the longitudinal axis 38, as it extends along the distal direction.", "The anchor body 34 can further define at least one channel 42, such as a plurality of (e.g., at least two) channels 42, that extend into the perimeter 40, for instance toward the longitudinal axis 38.Each of the channels 42 can be configured to receive the strand of suture 28 (see FIGS.", "4A-B).", "For instance, respective ones of the channels 42 are configured to receive respective portions of the strand of suture 28.Each channel 42 can define a central axis 43a, and a first or proximal end 43b, and a second or distal end 43c that is spaced from the proximal end 43b along the central axis 43a.", "The channels 42 can extend along an entirety of the length of the anchor body 34 from the proximal end 36a to the distal end 36b, or can extend along a portion of the length of the anchor body 34.Thus, it can be said that the channels 42 can extend between the proximal and distal ends 43b and 43c, respectively, for instance from the proximal end 43b to the distal end 43c.", "The channels 42 can, for instance, be open to a proximal-most outer surface 54 of the anchor body 34, the proximal-most outer surface 54 extending from the outer perimeter 40 toward the longitudinal axis 38.The central axis 43a can extend parallel to the longitudinal axis 38, or can be angularly offset with respect to the longitudinal axis 38, and can define any shape as desired.", "The anchor body 34 can include any number of channels 42, such as a first channel 42a and a second channel 42b, that can be disposed on opposite sides with respect to the longitudinal axis 38, and thus be opposite each other with respect to the longitudinal axis 38, or can be angularly offset with respect to the longitudinal axis 38 at any angle of separation as desired.", "Thus, a first line 35a perpendicular to the longitudinal axis 38 that intersects both the longitudinal axis 38 and the central axis 43a of the first channel 42a can define the angle of separation with respect to a second line 35b that is perpendicular to the longitudinal axis 38 and intersects both the longitudinal axis 38 and the central axis 43a of the second channel 42b.", "The angle of separation al can be substantially 180 degrees, or any angle between zero and 180 degrees.", "In accordance with the illustrated embodiment, the anchor body 34 can include a third channel 42c and a fourth channel 42d that can define an angle of separation with respect to each other, for instance 180 degrees as described above with respect to the first and second channels 42a and 42b.", "Further, the channels 42 can be equidistantly spaced from each other about the perimeter 40 as illustrated, or can be variably spaced from each other about the perimeter 40 as desired.", "Thus, adjacent ones of the channels 42, such as the first channel 42a and either or both of the third and fourth channels 43c and 43d, respectively, can define an angle of separation α2 of substantially 90 degrees.", "The channels 42 that are spaced from each other by an angle of separation that is greater than 90 degrees and less than or equal to 180 degrees can be referred to as opposed channels.", "The channels 42 that are spaced from each other by an angle of separation that is greater than between 0 degrees and less than or equal to 90 degrees can be referred to as adjacent channels.", "As will be appreciated from the description below, at least a portion up to all of the anchor body 34 can be made from a deformation material 44, which can be polymeric, that comprises a deformation material responsive to an applied energy that causes the deformation material, and thus the anchor body 34 at the deformation material, to deform.", "The applied energy can be a laser or any suitable alternative energy, such as an electrical current,.", "In accordance with one embodiment, the deformation material 44 can define at least a portion of the anchor body 34, including at least a portion up to an entirety of one or more up to all of the channels 42.For instance, the deformation material 44 can be located in a region as illustrated in FIGS.", "3A-C that can be spaced from one or both of the proximal end 36a and the distal end 36b.", "Alternatively, the deformation material 44 can comprise an entirety of the anchor body 34, from the proximal end 36a to the distal end 36b, as illustrated in FIGS.", "2A-2E.", "The deformation material 44 can be responsive to the applied energy so as to deform at least a portion of the anchor body 34 and capture the received portion of the strand of suture 28 therein with respect to movement relative to the anchor body 34.Deformation of the deformation material 44 in response to the applied energy can further cause the anchor body 34 to similarly deform and become fixed to the bone 24.In accordance with one embodiment, the deformation that causes the anchor body 34 to become fixed to the bone can similarly cause the anchor body 34 to capture the received portion of the suture strand 28 therein with respect to movement relative to the anchor body 34.For instance, in accordance with one embodiment, the deformation material 44 is configured to deform in response to the applied energy and close at least a portion of each of the channels 42 and capture the respective received portion of the strand of suture 28 in the channels 42 with respect to movement relative to the anchor body 34.Deformation of the deformation material 44 in response to the applied energy can further cause the anchor body 34 to similarly deform and become fixed to the bone 24.In accordance with one embodiment, the deformation that causes the anchor body 34 to become fixed to the bone can similarly cause the channels 42 to close and capture the received strand of suture 28 therein.", "In accordance with one embodiment, the deformation material 44 can be disposed in a middle region of the anchor body 34 that is spaced from the proximal end 36a and the distal end 36b.", "For instance, the middle region can include a location that is disposed midway between the proximal end 36a and the distal ends 36b.", "The bone anchor body 34 can be constructed so as to prevent the applied energy from traveling to the distal end 36b.", "For instance, the bone anchor body 34 can define any color as desired, or be made of any one or more suitable materials as desired, that can prevent the applied energy from traveling to at least one select region of the bone anchor body 45, such as the distal end 36b.", "Examples of deformation materials of the type described herein are disclosed in U.S. Patent Application Publication No.", "2010/0241229 A1, published Sep. 23, 2010, and U.S. Patent Application Publication No.", "2012/0129131 A1, published May 24, 2012, the disclosure of each of which is incorporated by reference as if set forth in its entirety herein.", "As described above, each of the channels 42 can define a central axis 43a, and a first or proximal end 43b, and a second or distal end 43c that is spaced from the proximal end 43b along the central axis 43a.", "In accordance with one embodiment, the distal ends 43c of the channels 42 can be open to each other, such that the strand of suture 28 can extend distally along one of the channels 42 out the distal end 43c of the channel, into the distal end 43c of another one of the channels 42 and proximally along the other one of the channels 42.For instance, the distal ends 43c of the channels 42 can be open to each other at the distal end 36b of the anchor body 34.In accordance with one embodiment, the anchor body 34 can define a void 46 that extends along the proximal direction into the tip 37.The void 46 can be aligned with the longitudinal axis 38, and can be open to the distal ends 43c of each of the channels 42, including the first channel 42a, the second channel 42b, the third channel 42c, and the fourth channel 42d.", "While the void 46 is open through the tip 37 along the distal direction as illustrated, it should be appreciated that the tip 37 can alternatively be enclosed, such that the tip 37 defines a distal boundary of the void 46.Nevertheless, the void 46 can be open to the outer perimeter 40 and to each of the distal ends 43c of the channels 42.Thus, the distal ends 43c of each of the third and fourth channels 42c and 42d are open to both each other and the distal ends 43c of the first and second channels 42a and 42b, for instance at the distal end 36b.", "Similarly, the distal ends 43c of each of the first and second channels 42a and 42b are open to both each other and the distal ends 43c of the third and fourth channels 42c and 42d, for instance at the distal end 36b.", "For instance, the distal ends 43c can be open to each other via the void 46, such that strands of suture extending from the distal end 43c of one of the channels 42 to the distal end 43c of another one of the channels 42 can extend across the void 46.Alternatively, the distal ends 43c of one or more up to all of the channels 42 can be continuous with each other.", "Each channel 42 can be defined by at least one wall that can define a base 45a of the anchor body 34 and opposed side walls 45b of the anchor body 34 that extend from the base 45a toward, for instance to, the perimeter 40.The void 46 can be at least partially defined by a floor 51 that extends toward the perimeter 40, and the anchor body 34 can define respective interface 49 between the bases 45a and the floor 51.The interface 49 can be beveled as desired.", "With continuing reference to FIGS.", "2A-E, the anchor 26 can define an insertion aperture 52 that extends into the anchor body 34 and is configured to receive an energy emitting instrument 70 (see FIG.", "6A) that is configured to apply the energy that causes the deformation material 44 to deform as described herein.", "For instance, the anchor body 34 can define the insertion aperture 52 that extends into the proximal end 36a, and in particular the proximal-most surface 54, substantially along the distal direction.", "For instance, the insertion aperture 52 can be centrally disposed with respect to the outer perimeter and the longitudinal axis 38, and thus can extend substantially along the longitudinal axis 38.As will be described in more detail below, the insertion aperture 52 can be sized to receive an energy emitting instrument 70 (see FIG.", "5A) that is configured to apply the energy that causes the deformation material 44 to deform in the manner described herein.", "The insertion aperture 52 can be round, such as cylindrical, in shape, or can define any suitable alternative shape as desired.", "The insertion aperture 52 can be defined by a base 53a of the anchor body 34 and at least one inner side wall 53b that can extend from the base 53a along the proximal direction, for instance to the proximal outer surface 54 of the proximal end 36a.", "In accordance with one embodiment, the proximal end 36a that defines the insertion aperture 52 can be integral and monolithic with one or more up to all of the distal end 36b, the base 45a of one or more up to all of the channels 42, the side walls 45b of one or more up to all of the channels 42, the floor 51, and the interfaces 49.Alternatively, as illustrated in FIGS.", "3A-C, the bone anchor can include an insert 56 that defines an insert body 59 having a proximal end 56a, a distal end 56b spaced from the proximal end 56a along the distal direction, and an outer perimeter 56c that extends from the proximal end 56a to the distal end 56b.", "The insert 56 can define the insertion aperture 52 that is configured to receive the energy emitting instrument 70 (see FIG.", "6A) that is configured to apply the energy to the deformation material 44.The bone anchor 26 can define an aperture 60 that extends into the anchor body 34 and is sized and configured to receive the insert 56.For instance, the body 34 can define the aperture 60 that extends into the proximal end 36a substantially along the distal direction.", "For instance, the insertion aperture 60 can be centrally disposed with respect to the outer perimeter and the longitudinal axis 38, and thus can extend substantially along the longitudinal axis 38.The insert 56 can be insertable in the aperture 60 in any manner as desired.", "For instance, the perimeter 56c of the insert 56 can define a cross-sectional dimension substantially equal to that of the aperture 60, such that the insert 56 can be press-fit into the aperture 60.Alternatively, the insert 56 can be secured to the anchor body 34 in the aperture 60 using any known adhesive, fastener, or the like.", "The insert 56 can define a head 61 that extends out from the proximal end 56a of the body 59 and is configured to abut the proximal most surface 54.The head 61 can define channels 57 that are aligned with the channels 42 and extend through the head 61 along the distal direction.", "Thus, the channels 42 and 57 can combine to define the respective channels that are configured to receive the strands of suture 28 as described herein.", "The insert 56 can be made from a material different than the deformation material, such that the insert 56 does not deform in response to application of the energy.", "Referring now to FIG.", "5A, a soft tissue fixation system 62 can include an actuation assembly 64 and the soft tissue fixation assembly 20.The soft tissue fixation assembly 20 can include at least one bone anchor, such as a plurality (such as a pair or more) of bone anchors 26 and at least one strand of suture 28.The actuation assembly 64 can include the energy emitting instrument 70 and a tensioner 72 that supports the energy emitting instrument 70.The energy emitting instrument 70 is configured to apply energy to the anchor body 34, thereby causing the deformation material 44 to deform.", "As the deformation material 44 deforms, the tensioner 72 can maintain tension in the suture 28.The energy emitting instrument 70 can include an energy source 74 and an energy conduit 76 that extends from the energy source 74 and is configured to be inserted into the insertion aperture 52 so as to be configured to apply energy to the implant body 34 in sufficient quantity that the deformation material 44 deforms in response to the applied energy, or can otherwise be operably coupled to the implant body 34 so as to be configured to apply energy to the implant body 34 in sufficient quantity that the deformation material 44 deforms in response to the applied energy.", "In accordance with the illustrated embodiment, the energy emitting instrument 70 is a laser, the energy source 74 is a laser source configured to emit energy in the form of a laser beam.", "The energy conduit 76 can define a light pipe that extends from the laser source, the light pipe configured to communicate the laser beam from the laser source to the implant 26, and apply the energy in the form of the laser beam to the implant body 34.The tensioner 72 can include a first support member 78 configured to support the energy conduit 76, and a second support member 80 that is spaced from the first support member along a direction that can be parallel, such as coincident, with the longitudinal axis 38.In accordance with the illustrated embodiment, the second support member 80 can be spaced from the first support member 78 along the proximal direction, such that the first support member 78 is disposed between the second support member 80 and the bone anchor 26 that receives the energy conduit 76.The second support member 80 is configured to attach to the suture 28 that extends through at least one of the channels 42 of the bone anchor 26.The tensioner 72 can include a biasing member 82, for instance a spring such as a coil spring that is connected between the first and second support members 78 and 80, respectively.", "The tensioner 72 is configured to bias one of the first and second support members 78 and 80, respectively, to move relative to the other of the first and second support members 78 and 80, respectively.", "During operation, the biasing member 82 applies a force to the second support member 80 that biases the second support member to move along the proximal direction away from the bone anchor 26, and also away from the first support member 78.Alternatively, the second support member 80 can be disposed distal of the first support member 78, and thus between the first support member 78 and the bone anchor 26, such that the biasing member 82 applies a force to the second support member 80 that biases the second support member 80 to move along the proximal direction away from the bone anchor 26 and toward the first support member 78.With continuing reference to FIG.", "5A, a method of anchoring suture to bone can include the step of inserting the strand of suture 28 into at least one channel 42 of an initial bone anchor, which can be defined as a first bone anchor 26.In particular, the strand of suture 28 can be inserted into first and second select ones of the channels 42, such that the strand of suture 28 extends from the proximal end 36a, distally along the first select one of the channels 42, out the distal end of the first select one of the channels 42 as described above, into the distal end of the second select one of the channels 42, proximally along the second select one of the channels 42, and out the proximal end 36a of the anchor body.", "The first and second select channels can be opposed channels or adjacent channels as described above.", "After the strand of suture 28 has been inserted into the at least one channel 42, the bone anchor 26 can be driven into the bone 24.A pilot hole can be drilled or otherwise formed in the bone, and the initial anchor 26 can be driven into the pilot hole, or the anchor 26 can be driven into the bone without first forming the pilot hole.", "Next, the energy conduit 76 is inserted into the insertion aperture 52 or otherwise operably coupled to the anchor body 34.At least one end of the strand of suture 28, for instance first and second opposed ends 28a and 28b that extend out from different ones of the channels 42 of the initial bone anchor, can be fixedly attached to the second support member 80 prior to deformation of the initial bone anchor.", "Referring now to FIG.", "5B, the energy source 74 s then actuated so as to cause the energy emitting instrument 70, for instance the energy source 74, to emit energy, which can be in the form of a laser beam, to the conduit 76.The energy emitting instrument, for instance at the conduit 76, can apply the energy to the bone anchor body 34 so as to cause the deformation material 44 to deform, thereby causing the anchor body to deform and 1) fix to the bone 24, and 2) capture the strand of suture 28 therein with respect to movement relative to the bone anchor 26.For instance, the energy emitting instrument, for instance at the conduit 76, can apply the energy to the bone anchor body 34 so as to cause the deformation material 44 to deform and close at least the portion of the channel 42 that is defined by the deformation material 44, thereby capturing the strand of suture 28 therein with respect to movement relative to the bone anchor 26.Thus, the strand of suture 28 is unable to move relative to the bone anchor 26 at the portion of the channel 42 that has been closed.", "In accordance with the illustrated embodiment, both channels within which the suture 28 resides can be closed.", "It is appreciated that prior to deformation of the first bone anchor, the first bone anchor 26 defines a first length L1 along the longitudinal axis 38 between the proximal end 36a and the distal end 36b.", "As the deformation material 44 deforms, the distal end 36b can be drawn toward the proximal end 36a, thereby shortening the length of the bone anchor to a second length L2 along the longitudinal axis 38 between the proximal end 36a and the distal end 36b, wherein the second length L2 is greater than L1.For instance, the biasing force of the biasing member 82 causes the second support member 80, which is attached to the suture 28, to translate proximally as the deformation material 44 of the anchor body 34 softens and deforms in response to the applied energy, thereby promoting deformation of the anchor body 34 as described above.", "Furthermore, translation of the second support member 80 can cause the first and second ends 28a and 28b to likewise translate proximately, thus maintaining a desired level of tension in the strand of suture 28 through completion of the application of energy to the anchor body 34 and through completion of the resulting deformation.", "It is further appreciated that a maximum width of the anchor body 34 along a direction perpendicular to the longitudinal axis 38 can increase in response to deformation of the deformation material 44, thereby securely anchoring the bone anchor in the bone 24.It should be appreciated, of course, that the biasing force can be produced by any suitably constructed tensioner 72, or manually, as desired.", "Referring now to FIG.", "5C, it is appreciated that the first end 28a is fixed to the initial bone anchor.", "Accordingly, the first end 28a can be cut at a location adjacent to the proximal end 36a of the anchor body 34, or the first end 28a can define a free end of the strand of suture 28 that extends out from the bone 24.The free end can be loosely attached to the second support member 80, or can be free from the second support member 80.As is described in more detail below, the free end can be attached to a final one of the bone anchors 26.The second end 28b can then be inserted into first and second select channels of a subsequent bone anchor, which can be define as a second bone anchor 26b, in the manner described above with respect to the first anchor 26a.", "The first and second channels 42 can be opposed channels or adjacent channels as described above.", "The second end 28b can extend out the anchor body 34 and can be attached to the second support member 80 in the manner described above.", "After the strand of suture 28 has been inserted into the channels 42 of the second bone anchor 26b, the second bone anchor 26b can be driven into the bone 24 in the manner described above.", "It should be appreciated that the second bone anchor 26 can be driven through the soft tissue 22 and into the bone 24.Next, as illustrated in FIG.", "5D, the method can include the step of applying energy to the second bone anchor 26b so as to cause the deformation material 44 of the second bone anchor 26b to deform, thereby capturing the strand of suture 28 therein with respect to movement relative to the second bone anchor 26b.", "For instance, deforming the deformation material 44 can close the portion of the channels 42 that is defined by the deformation material 44, thereby capturing the received strand of suture 28 therein with respect to movement relative to the second bone anchor 26b.", "The biasing member 82 can apply a biasing force to the second support member 80 that causes the second support member 80 to move away from both the first support member 78 and the first and second bone anchors 26a and 26b, thereby promoting deformation and maintaining tension in the strand of suture 28 as the length of the second bone anchor 26b decreases in the manner described above with respect to the first bone anchor 26a.", "It should be appreciated that the strand of suture 28 is continuous, and is fixedly attached to the first and second bone anchors 26a and 26b.", "Thus, the strand of suture 28 extends continuously from the first bone anchor 26a, over the bone 24, across the interface 30 between the soft tissue 22 and the bone 24, over the soft tissue 22, to the second bone anchor 26b.", "Because the strand of suture 28 is in tension and is anchored to the first and second bone anchors 26a and 26b inside the bone 24, the strand of suture 28 forces the soft tissue 22 into contact with the bone 24.It should be appreciated that the method steps of inserting the strand of suture 28 into at least one such as a pair of channels, driving the bone anchor into the bone, for instance possibly through the soft tissue 22 and into the bone 24, and applying the energy to the anchor body can be sequentially repeated for at least one additional bone anchor, such a third bone anchor 26c as illustrated in FIG.", "6A.", "For instance, the method steps of inserting the strand of suture 28 into at least one such as a pair of channels, driving the bone anchor into the bone, for instance possibly through the soft tissue 22 and into the bone 24, and applying the energy to the anchor body can be sequentially repeated for a plurality of additional bone anchors 26c.", "In accordance with one embodiment, the energy is applied to a given one of the bone anchors 26 prior to inserting the strand of suture 28 into a channel 42 of another one of the bone anchors 26 that is to be subsequently anchored to the bone 24.As described above, at least one strand of suture can be inserted into the channels 42 of the anchors 26 prior to driving the anchors into bone and applying the energy to the respective anchor bodies 34.For instance, as illustrated in FIG.", "6A, a single continuous strand of suture 28 can be fixedly attached sequentially to at least two, such as three, bone anchors 26a, 26b, and 26c.", "Alternatively, as illustrated in FIG.", "6B, it should be appreciated that the steps of inserting a strand of suture into at least one channel of the bone anchors 26 can include the step of inserting a pair or more, and thus a plurality, of strands of suture 28 into the at least one channel.", "Accordingly, the step of applying energy to the implant body causes the anchor body, and thus the anchor, to deform so as to secure each of the plurality of strands of suture 28 to the respective anchor body.", "Deformation of the anchor body can further cause the anchor body to fix to the bone 24, and can cause the portion of the channels defined by the deformation material to close so as to secure the strands of suture 28 therein with respect to movement relative to the anchor body.", "A free end of the single strand of suture 28, or of a second strand of suture 28, can extend out the proximal end of the bone anchor 26, and out the bone 24, such that it can be attached to an auxiliary implant, such as a soft tissue or bone graft, and then secured to itself or the other strand of suture 28, for instance at a knot 29, thereby attaching the auxiliary implant to the soft tissue 22 or bone 24.Referring now to FIGS.", "7A-7E in general, it is appreciated that the soft tissue fixation assembly 20 can include as many bone anchors 26 as desired, disposed in any arrangement as desired.", "For instance, as illustrated in FIG.", "7A, the first bone anchor 26a is shown inserted into the bone without being driven through the soft tissue 22, and the second one anchor 26b is shown inserted through the soft tissue 22 and into the bone 24.The first and second bone anchors 26a and 26b can define a row 32 of bone anchors.", "Referring to FIG.", "7B, the plurality of bone anchors 26c, in combination with the first and second bone anchors 26a and 26b can define a pair of rows, such as a first row 32a and a second row 32b.", "For instance, the row defined by the first and second bone anchors 26a and 26b can define the first row 32a, and the plurality of bone anchors 26c can define the second row 32b that is adjacent the first row 32a.", "The strand of suture 28 can extend from the first row 32a to the second row 32b.", "For instance, the strand of suture 28 can extend through adjacent channels 42 (see FIG.", "2D) of one of the bone anchors, such as the second bone anchor 26b illustrated in FIG.", "7B, so as to extend from the first row 32a along a column direction toward the second row 32b.", "The strand of suture 28 can then extend through adjacent channels of a subsequent one of the bone anchors, such as one of the plurality of bone anchors 26c illustrated in FIG.", "7B, so as to extend from the column direction to the row direction, for instance along the second row 32b.", "With continuing reference to FIG.", "7B, the step of driving a final bone anchor 26d of the plurality of bone anchors 26c can include the step of driving the final bone anchor 26d into the bone 24 at a location spaced from the first bone anchor 26a.", "Thus, the strand of suture 28 is not connected directly from the final bone anchor 26d to the first bone anchor 26a.", "Because the strand of suture 28 is not directly connected between the bone anchors 26 of every adjacent pair of bone anchors 26, the arrangement defined by the bone anchors 26 can be referred to as an open arrangement.", "As described above, the soft tissue fixation assembly 20 can include as many bone anchors as desired, configured in any arrangement as desired.", "For instance, the soft tissue fixation assembly 20 can define as many rows 32 as desired.", "Referring to FIG.", "7E, the suture 28 of the soft tissue fixation assembly 20 can extend from the second bone anchor 26b to a first one of the plurality of bone anchors 26c along the first row 32a.", "In accordance with one embodiment, the strand of suture 28 can be inserted into opposed channels of the second bone anchor 26b, wherein the opposed channels are spaced from each other along a direction that is substantially parallel with the row 32a.", "The suture 28 can extend from the second bone anchor 26b toward a first one of the plurality of bone anchors 26c.", "The strand of suture 28 can be inserted into adjacent columns of the first one of the plurality of bone anchors 26c.", "Thus, the suture 28 can extend from the second bone anchor 26b along the row 32a to the first one of the plurality of bone anchors 26c, and along a column direction from the first one of the plurality of bone anchors 26c to a second one of the plurality of bone anchors 26c that lies along the second row 32b.", "The strand of suture 28 can be inserted into adjacent columns of the second one of the plurality of bone anchors 26c so as to extend from the first one of the plurality of bone anchors 26c to the second one of the plurality of bone anchors 26c along the column direction, and along the second row 32b from the second one of the plurality of bone anchors 26c to another one of the plurality of bone anchors.", "Of course, it should be appreciated that the strand of suture 28 can be inserted into any channels of the bone anchor 26 as desired so as to extend along a respective row 32, or to extend from a respective row along the column direction, or to extend from a column direction to a respective row.", "It should be further appreciated that the soft tissue fixation assembly 20 can define as many bone anchors as desired arranged along a given column direction.", "It should be further appreciated still that the soft tissue fixation assembly 20 can define a chain configuration having a plurality of rows of bone anchors 26, each row defined by two or more bone anchors 26, and the rows of adjacent pairs of rows (thus rows that are partially defined by a common one of the anchors 26) angularly offset from each other at an angle between 90 degrees and 180 degrees, or alternatively between 0 degrees and 90 degrees (and thus an angle other than 90 degrees).", "Thus, the first anchor 26a can be disposed at a first terminal end of the chain, and the final bone anchor 26d can be disposed at a second terminal end of the chain.", "Referring now to FIG.", "7C, the suture 28 can be connected between the final bone anchor 26d and the first bone anchor 26a.", "For instance, as described above with reference to FIG.", "5C, the first end 28a of the strand of suture 28 can define a free end that extends out from the first bone anchor 26a and the bone 24.Similarly, the second end 28b of the strand of suture 28 can define a free end that extends out from the final bone anchor 26d and the bone 24.The free ends that are defined by the first and second ends 28a and 28b can be attached to each other in accordance with any suitable embodiment, so as to directly attach the suture 28 to the last bone anchor 26d and the first bone anchor 26a.", "For instance, the free ends can be tied to each other, or secure to each other via any suitable fastener.", "Because the strand of suture 28 is directly connected between the bone anchors 26 of every adjacent pair of bone anchors 26, the arrangement defined by the bone anchors 26 can be referred to as a closed arrangement.", "Referring now to FIG.", "7D, the bone anchors 26 can define a closed arrangement in accordance with an alternative embodiment.", "For instance, the plurality of additional bone anchors 26c can define a select bone anchor 26e that is driven into the bone 24 and deformed before the final bone anchor 26d is driven into the bone.", "As described above, the first end 28a of the strand of suture 28 can define a free end that extends out from the first bone anchor 26a and the bone 24 as described above.", "Furthermore, the second end 28b of the strand of suture 28 can define a free end that extends out from the select bone anchor 26e and the bone 24.The free end defined by the first end 28a of the strand of suture 28 can be inserted into at least one channel of the final bone anchor 26d.", "For instance, the free end defined by the first end 28a of the strand of suture 28 can be inserted into a first channel 42 of the final bone anchor 26d, and out of a second channel 42 of the final bone anchor 26d.", "The first and second channels of the final bone anchor 26d can be adjacent channels or opposed channels as described above.", "Similarly, the free end defined by the second end 28b of the strand of suture 28 can be inserted into at least one channel of the final bone anchor 26d.", "For instance, the free end defined by the second end 28b of the strand of suture 28 can be inserted into a first channel 42 of the final bone anchor 26d, and out of a second channel 42 of the final bone anchor 26d.", "The first and second channels can be adjacent channels or opposed channels as described above.", "In accordance with one embodiment, the first channel of the free end that receives the first end 28a can define the second channel that receives free end defined by the second end 28b.", "Similarly, the first channel that receives second end 28b can define the first channel that receives the first end 28a.", "It should be appreciated, of course, that the free ends defined by the first and second ends 28a and 28b, respectively, can be inserted into different channels of the final bone anchor 28d.", "In accordance with the embodiment illustrated in FIG.", "2D, the first and second bone anchors 26a and 26b can each be driven through the soft tissue 22 and into the bone 24, and the select and final ones 26e and 26d, respectively, of the plurality of bone anchors 26c can be inserted into the bone 24 without being driven through the soft tissue 22.The foregoing description is provided for the purpose of explanation and is not to be construed as limiting the soft tissue fixation system, or components thereof.", "While various embodiments have been described with reference to preferred embodiments or preferred methods, it is understood that the words which have been used herein are words of description and illustration, rather than words of limitation.", "Furthermore, although the embodiments have been described herein with reference to particular structure, methods, and embodiments, the disclosure is not intended to be limited to the embodiments specifically described herein.", "For instance, it should be appreciated that structure and methods described in association with one embodiment are equally applicable to all other embodiments described herein unless otherwise indicated.", "Those skilled in the relevant art, having the benefit of the teachings of this disclosure, may effect numerous modifications to the embodiments as described herein, and changes may be made without departing from the scope of the present invention, for instance as set forth by the appended claims." ] ]
Patent_15874120
[ [ "SYSTEMS AND METHODS FOR IMPROVED AND EFFICIENT DETERMINATION OF THE SPECIFIC ABSORPTION RATE (SAR) IN MRI", "Magnetic resonance imaging (MRI) systems and methods to effect improved and more efficient determination of the specific absorption rate (SAR) are described.", "The SAR is calculated based upon a derived relationship between a body surface area (BSA) and a portion of the total radio frequency (RF) energy delivered to RF transmit coil that is deposited in the imaging subject, and the scanning is controlled in accordance with the calculated SAR." ], [ "1.A magnetic resonance imaging (MRI) system comprising: an MRI gantry having components including a static magnetic field coil, gradient magnetic field coils, at least one radio frequency (RF) coil configured to transmit RF nuclear magnetic resonance (NMR) RF excitation pulses into an imaging volume and to receive NMR RF signals from a patient located in the imaging volume; and one or more computer control circuits configured and connected to control said gantry components to perform operations comprising: determine a power ratio, based upon a body surface area (BSA) for the patient, between total power delivered to the at least one RF coil and power deposited in the patient; and calculate a specific absorption rate (SAR) based upon at least the determined power ratio and the total power.", "2.The MRI system according to claim 1, wherein the one or more computer control circuits are further configured to: receive one or more input parameters including information regarding the patient, and calculate the BSA based upon the received one or more input parameters.", "3.The MRI system according to claim 2, wherein the information regarding the patient include at least one of weight and height of the patient.", "4.The MRI system according to claim 1, wherein the one or more computer control circuits are further configured to monitor the total power.", "5.The MRI system according to claim 1, wherein the one or more computer control circuits are further configured to estimate the total power based upon pulse sequences during a scan of the patient.", "6.The MRI system according to claim 1, wherein determining a power ratio comprises: accessing a memory having stored therein predetermined data associating each of a plurality of BSA values with a respective corresponding power ratio; and ascertaining, based upon the accessed predetermined data, a power ratio corresponding to the calculated BSA as the determined power ratio.", "7.The MRI system according to claim 6, wherein: the predetermined data corresponds to a derived linear relationship between the BSA values and the corresponding power ratios, and ascertaining a power ratio is based upon the derived linear relationship.", "8.The MRI system according to claim 6, wherein: the plurality of BSA values and the corresponding power ratios include measured data from a plurality of patients.", "9.The MRI system according to claim 1, wherein: determining a power ratio is based upon the calculated BSA and a landmark, the landmark corresponding to an area, located within the imaging volume, of the patient.", "10.The MRI system according to claim 9, wherein determining a power ratio further includes: accessing a memory having stored therein, for each of a plurality of landmarks, predetermined data associating each of a plurality of BSA values with a respective corresponding power ratio for the landmark; and ascertaining, based upon a portion of the accessed predetermined data corresponding to the landmark, a power ratio corresponding to the calculated BSA as the determined power ratio.", "11.The MRI system according to claim 10, wherein: the accessed predetermined data includes a derived linear relationship between BSA values and respective corresponding power ratios for the landmark, and ascertaining a power ratio is based upon the derived linear relationship.", "12.The MRI system according to claim 11, wherein the linear relationship incorporates a safety margin along a line fitted to a plurality of data points representing the BSA values and the corresponding power ratios.", "13.The MRI system according to claim 12, wherein the linear relationship is based upon a piece-wise linear fit of the plurality of data points representing BSA values and corresponding power ratios and one or more safety margins applied to the piecewise linear fit.", "14.The MRI system according to claim 11, wherein the accessed predetermined data provides a first value and a second value such that the power ratio is equal to the first value times the calculated BSA plus the second value.", "15.The MRI system according to claim 1, wherein calculating the SAR is based upon the determined power ratio, the total power, and the weight of the patient.", "16.The MRI system according to claim 14, wherein calculating the SAR is based upon information regarding the one or more pulse sequences.", "17.A magnetic resonance imaging (MRI) method comprising: configuring and using an MRI system having (a) a static magnetic field coil, (b) gradient magnetic field coils, (c) at least one radio frequency (RF) coil configured to transmit nuclear magnetic resonance (NMR) RF excitation pulses into an imaging volume and to receive NMR RF signals from a patient located in the imaging volume, and (d) one or more computer control circuits to perform operations comprising: determining a power ratio, based upon a body surface area (BSA) for the patient, between the total power delivered to the at least one RF coil and power deposited in the patient; and calculating a specific absorption rate (SAR) based upon at least the determined power ratio and the total power.", "18.A system for calculating a specific absorption rate (SAR), the system comprising one or more computer control circuits configured to: determine a power ratio, based upon a body surface area (BSA) for a patient, between total power delivered to at least one RF coil and power deposited in the patient; and calculate a SAR based upon at least the determined power ratio and the total power." ], [ "<SOH> FIELD <EOH>The subject matter below relates generally to magnetic resonance imaging (MRI), and more particularly to systems and methods for improved and more efficient determination of the specific absorption rate (SAR) in MRI." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 is a high-level schematic block diagram of an MRI system adapted for improved and more efficient determination of the SAR in MRI scanning, in accordance with one or more embodiments.", "FIG.", "2 illustrates a flowchart of an MRI scanning process with improved and more efficient determination of the SAR in accordance with one or more embodiments.", "FIG.", "3 illustrates a flowchart of a process for configuring information regarding the relationship between a patient's body surface area (BSA) and a power ratio in accordance with one or more embodiments.", "FIG.", "4 illustrates a graph showing data points relating BSA to power ratio for a landmark, and an example linear fit, in accordance with one or more embodiments.", "FIG.", "5 illustrates the graph of FIG.", "4 being enhanced with a linear relationship accounting for an error margin, in accordance with one or more embodiments.", "FIG.", "6 illustrates a graph showing data points relating BSA to power ratio for a landmark where some of the data points are obtained by simulation and other data points are obtained by experiments, and an example piece-wise linear fit, in accordance with one or more embodiments.", "FIG.", "7 is a schematic illustration of a data structure in memory storing the relationship between the BSA and the power ratio, in accordance with one or more embodiments.", "FIG.", "8 illustrates a schematic drawing of current sensing loop that can be used to determine the power loss of the transmit coil(s) in accordance with one or more embodiments.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a divisional of U.S. patent application Ser.", "No.", "14/573,498 filed Dec. 17, 2014, the entire contents of which are hereby incorporated by reference.", "FIELD The subject matter below relates generally to magnetic resonance imaging (MRI), and more particularly to systems and methods for improved and more efficient determination of the specific absorption rate (SAR) in MRI.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a high-level schematic block diagram of an MRI system adapted for improved and more efficient determination of the SAR in MRI scanning, in accordance with one or more embodiments.", "FIG.", "2 illustrates a flowchart of an MRI scanning process with improved and more efficient determination of the SAR in accordance with one or more embodiments.", "FIG.", "3 illustrates a flowchart of a process for configuring information regarding the relationship between a patient's body surface area (BSA) and a power ratio in accordance with one or more embodiments.", "FIG.", "4 illustrates a graph showing data points relating BSA to power ratio for a landmark, and an example linear fit, in accordance with one or more embodiments.", "FIG.", "5 illustrates the graph of FIG.", "4 being enhanced with a linear relationship accounting for an error margin, in accordance with one or more embodiments.", "FIG.", "6 illustrates a graph showing data points relating BSA to power ratio for a landmark where some of the data points are obtained by simulation and other data points are obtained by experiments, and an example piece-wise linear fit, in accordance with one or more embodiments.", "FIG.", "7 is a schematic illustration of a data structure in memory storing the relationship between the BSA and the power ratio, in accordance with one or more embodiments.", "FIG.", "8 illustrates a schematic drawing of current sensing loop that can be used to determine the power loss of the transmit coil(s) in accordance with one or more embodiments.", "DETAILED DESCRIPTION Example embodiments of the subject matter disclosed herein provide for MR imaging with improved and more efficient determining of the specific absorption rate (SAR) during image acquisition.", "In embodiments, the SAR is calculated in a manner customized to each patient, so that efficiency of scanning is improved when compared to conventional techniques, while also ensuring patient safety.", "MRI scanning involves the transmission of RF pulses directed at a patient's body.", "Typically, the RF pulses are transmitted according to a predetermined pulse sequence.", "Some of the RF energy of the transmitted pulses may be absorbed by the body (e.g., particularly the body's tissue).", "Such RF energy absorption can raise the temperature of the core (whole body) and/or localized areas in the patient's body.", "Because of the resulting heating effects and potential injury risks, RF power deposition in tissue is a major safety concern for MRI scans.", "Therefore, the scanning process is typically controlled so as to keep the resulting temperature increase within certain limits.", "However, instead of directly monitoring the tissue temperature during scanning, the SAR is used in controlling the scanning process.", "In many implementations, prior to scanning, the pulse sequence is configured such that SAR thresholds are not exceeded, and then, during scanning, the resulting SAR is monitored to ensure that it remains at or below the one or more thresholds.", "Configuration of pulse sequences may be affected by SAR thresholds.", "Moreover, the imaging speed (e.g.", "number of slices scanned per TR) is often limited by the SAR.", "More efficient use of SAR thresholds can therefore result in faster and more efficient scanning processes.", "The SAR is defined as the absorbed power (typically in watts) per unit (typically a kilogram) of body mass.", "A SAR of 1 watt per kg represents an increase of temperature of an insulated slab by about 1 degree Celsius per hour.", "Power deposition and SAR can change significantly with various factors (patient body shape/size, imaging landmark etc.)", "and is difficult to generalize.", "A pulse energy method as described in NEMA (National Electrical Manufacturers Association) Standards Publication MS 8-2008 is commonly used for calculating the SAR in MRI.", "As will be understood, there are prescribed health and safety standards that limit the SAR so as to prevent patient damage during MRI.", "The NEMA standard calculates power absorbed by a patient by subtracting the RF power absorbed by the RF coil (Pcoil) from the total RF power (Ptotal) delivered to the the RF coil, the difference being divided by the patient's weight, as shown in equation (1).", "SAR = 1 weight  ( P total - P coil ) ( 1 ) Pcoil varies significantly with various scan conditions.", "Due to high variability of the SAR among different imaging subjects, SAR calculations on MR scanners are often configured to have excessive safety margins to protect all patients, and thus reduce imaging performance.", "Some conventional techniques determine SAR as a closest match with a large, pre-calculated database which covers many different scan conditions.", "However, because the actual subject being imaged may be substantially different from any point in the database, excessive safety margins may still be needed to account for subject variations.", "The excessive safety margins are relied upon to ensure that patient safety is not impaired due to SAR underestimation.", "Although possibly effective at reducing SAR-related injuries, such excessive safety margins reduce imaging performance and efficiency.", "Several SAR monitoring and calculation techniques for conventional MR scanners are described in U.S. Pat.", "Nos.", "6,759,847, 6,762,605, 6,841,999, 7,282,914.The U.S. Pat.", "No.", "6,759,847 patent describes pre-measurement of a desired patient position using a pre-scan, and then using the measured patient position in the calculation of the SAR.", "The U.S. Pat.", "No.", "6,762,605 patent describes a technique in which the RF power absorbed by a patient is logged over time, so that a performance history is created.", "This history is expanded into the future with calculated power values over time in order to predict the SAR.", "The U.S. Pat.", "No.", "6,841,999 patent describes a technique in which SAR values are pre-calculated and stored for a plurality of measurement situations, and a best matching pre-stored SAR is used depending on the current scanning conditions.", "The U.S. Pat.", "No.", "7,282,914 patent describes determining a power required to generate the necessary flip angles at locations from head-to-toe of the patient, and thereafter, finding the SAR value in a model that corresponds to the position of the subject being imaged and adjusting the duty cycle of the RF transmissions accordingly.", "In contrast to conventional techniques, example embodiments herein determine the SAR for a particular patient based upon a relationship between the RF absorption at a particular landmark and the body surface area (BSA).", "This relationship between the BSA and RF absorption more accurately reflects the imaging subject's loading than in conventional techniques, and also provides for mitigating some possible operator errors.", "The MRI system shown in FIG.", "1 includes a gantry 10 (shown in schematic cross-section) and various related system components 20 interfaced therewith.", "At least the gantry 10 is typically located in a shielded room.", "The MRI system geometry depicted in FIG.", "1 includes a substantially coaxial cylindrical arrangement of the static field B0 magnet 12, a Gx, Gy and Gz gradient coil set 14 and a large whole body radio frequency (RF) coil (WBC) assembly 16.Along the horizontal axis of this cylindrical array of elements is an imaging volume 18 shown as substantially encompassing the anatomy of interest (i.e., region of interest or “ROI”) for a patient 9 supported by a patient table 11.In some embodiments, a smaller array RF coil (not shown) might be coupled to a portion of the patient such that the imaging volume would include the area encompassed by the smaller array RF coil.", "As those in the art will appreciate, compared to the WBC (whole body coil), relatively small coils and/or arrays such as surface coils or the like are often customized for particular body parts (e.g., arms, shoulders, elbows, wrists, knees, legs, chest, spine, etc.).", "Such smaller RF coils are herein referred to as array coils (AC) or phased array coils (PAC).", "These may include at least one coil configured to transmit RF signals into the imaging volume and one or more receiver coils configured to receive RF signals from the imaging volume.", "An MRI system controller 22 has input/output ports connected to a display 24, keyboard 26 and printer 28.As will be appreciated, the display 24 may be of the touch-screen variety so that it provides control inputs as well.", "The MRI system controller 22, or a computer coupled to the MRI system controller 22, may be operated to provide the MRI sequence controller 30 information about a pulse sequence and/or to manage the operations of the entire system, according to installed software programs.", "The MRI system controller 22 may also serve as an element for instructing a patient to perform tasks, such as, for example, a breath hold by a voice massage produced using an automatic voice synthesis technique.", "The MRI system controller 22 interfaces with MRI sequence controller 30 which, in turn, controls the Gx, Gy and Gz gradient coil drivers 32, as well as the RF transmitter 34 and the transmit/receive switch 36 (if the same RF coil is used for both transmission and reception).", "The MRI sequence controller 30 includes suitable program code structure 38 for implementing MRI imaging (also known as nuclear magnetic resonance, or NMR, imaging) techniques.", "The MRI imaging techniques may include, for example, parallel imaging and/or other imaging sequences.", "The pulse-sequence information includes information required for operating the Gx, Gy and Gz gradient coil drivers 32, as well as the RF transmitter 34 and the transmit/receive switch 36 (if the same RF coil is used for both transmission and reception) according to a pulse sequence.", "Such information includes the strength, duration, and application timing of pulsed currents applied to the x-, y-, and z-coil.", "A duty cycle or TR is also controlled by the system controller 22 and/or sequence controller 30.The transmission of pulse sequences, duty cycle etc.", "may be controlled by the MRI system controller 22, MRI sequence controller 30, and/or MRI data processor 42 based on, for example, program code for determining and monitoring the SAR and/or for controlling the SAR.", "For example, a method such as method 200 described below in relation to FIG.", "2 can be performed by the MRI system controller 22, MRI sequence controller 30, and/or MRI data processor 42.The MRI system 20 includes an RF receiver 40 providing input to data processor 42 so as to create processed image data, which is sent to display 24.The MRI data processor 42 is also configured for access to system configuration parameters 46, program code structures 44 and program/data store 50.MRI program code structures 44 and 50 may, in addition to control logic for reconstructing MRI images, also include control logic to obtain MR data from RF coils 16 and/or any other receive coils.", "The MRI data processor 42 may also operate to execute methods, such as, method 300 shown in FIG.", "3 or parts thereof to obtain, process, and to store data associating BSA with power ratio for subsequent use in SAR determination.", "Although shown in FIG.", "1 as being located away from the RF coil 16, in some embodiments, any of RF transmitter 34, transmit/receive switch 36, and RF receiver 40 may be located in close proximity to, or on a surface of, the RF coils 16 and/or other RF coil.", "Also illustrated in FIG.", "1 is a generalized depiction of an MRI system program/data store 50 where stored program code structures (e.g., for image reconstruction, for defining graphical user interfaces (GUI), accepting operator inputs to same, for SAR determinations and monitoring, for BSA determination, for controlling the MRI system based upon the SAR), and configured or predetermined data (e.g., BSA to power ratio relation tables, SAR thresholds, pulse power profiles etc.)", "are stored in non-transitory computer-readable storage media accessible to the various data processing components of the MRI system.", "As those in the art will appreciate, the program store 50 may be segmented and directly connected, at least in part, to different ones of the system 20 processing computers having most immediate need for such stored program code structures in their normal operation (i.e., rather than being commonly stored and connected directly to the MRI system controller 22).", "Indeed, as those in the art will appreciate, the FIG.", "1 depiction is a very high-level simplified diagram of a typical MRI system with some modifications so as to practice exemplary embodiments described hereinbelow.", "The system components can be divided into different logical collections of “boxes” and typically comprise numerous digital signal processors (DSP), microprocessors and special purpose processing circuits (e.g., for fast A/D conversions, fast Fourier transforming, array processing, etc.).", "Each of those processors is typically a clocked “state machine” wherein the physical data processing circuits progress from one physical state to another upon the occurrence of each clock cycle (or predetermined number of clock cycles).", "Not only does the physical state of processing circuits (e.g., CPUs, registers, buffers, arithmetic units, etc.)", "progressively change from one clock cycle to another during the course of operation, the physical state of associated data storage media (e.g., bit storage sites in magnetic storage media) is transformed from one state to another during operation of such a system.", "For example, at the conclusion of an image reconstruction process and/or sometimes a coil sensitivity map generation process, an array of computer-readable accessible data value storage sites in physical storage media will be transformed from some prior state (e.g., all uniform “zero” values or all “one” values) to a new state wherein the physical states at the physical sites of such an array vary between minimum and maximum values to represent real world physical events and conditions (e.g., the internal physical structures of a patient over an imaging volume space).", "As those in the art will appreciate, such arrays of stored data values represent and also constitute a physical structure—as does a particular structure of computer control program codes that, when sequentially loaded into instruction registers and executed by one or more CPUs of the MRI system 20, causes a particular sequence of operational states to occur and be transitioned through within the MRI system.", "FIG.", "2 illustrates a flowchart of a process 200 for improved and more efficient determination of the SAR during MRI scanning, according to one or more embodiments.", "Operations 202-226 may be performed and/or controlled by MRI data processor 42, MRI system controller 22, and/or MRI sequence controller 30 shown in FIG.", "1.After entry to the improved SAR use routine, at operation 202, information regarding the patient (e.g.", "patient to be subjected to MRI scanning, also referred to as imaging subject) and the MRI system are provided to the MRI system.", "The information regarding the patient includes patient parameters such as the weight and/or height of the patient.", "Typically the patient information is entered into the MRI system by the operator, but automatic transmission of at least some patient information (e.g., patient weight being automatically transmitted to the system by a weighing scale) is contemplated as embodiments.", "System-related information may include a pulse sequence to be applied to the patient, and one or more anatomical landmarks to be scanned.", "In some embodiments, the pulse sequence is selected from a plurality of stored pulse sequences.", "Some embodiments provide for the user to specify the pulse sequence or to modify parts of a stored pulse sequence.", "The patient information and the system-related information provided and/or modified by the operator may be saved into a memory (e.g., a scanner database).", "At operation 204, the BSA value is calculated based upon patient information.", "According to some embodiments, the BSA is calculated using both the weight and height of the patient.", "For example, according to one embodiment BSA is calculated as in equation (2) below: BSA=0.024268×Wt0.628×Ht0.2864 (2) Equation (2) is based upon a technique described in G. B. Haycock et al., “Geometric method for measuring body surface area: A height-weight formula validated in infants, children, and adults”, The Journal of Pediatrics 93:62-66 (1978).", "Alternatively, another technique may be used to determine the BSA from patient-related information including the patient's weight and height.", "Additional example techniques for calculating BSA are discussed in Verbraecken et al., “Body surface area in normal-weight, overweight, and obese adults.", "A comparison study”, Metabolism Clinical and Experiment 55:515-524(2006), and Livingston et al., “Body surface area prediction in normal-weight and obese patients”, Am J Physical Endocrinol Metab 281:E586-E591 (2001).", "In some other embodiments, the BSA can be calculated without using the height.", "For example, a height-independent BSA formula, such as equation (3) below may be used: BSA(in2)=0.1173×We0.6466(kg) (3) According to equation (3), the BSA in square meters can be determined based only upon the weight of the patient expressed in kilograms.", "The above described techniques for determining the BSA are examples, and the use of other techniques for determining the BSA for a patient based upon patient-related information including the patient's weight and, at least in some embodiments, the patient's height are contemplated.", "At operation 206, an imaging landmark for scanning is selected.", "A landmark (sometimes referred to as an “imaging landmark”) is a part of the patient's body that is to be scanned.", "Examples of imaging landmarks that are frequently scanned include head, shoulder, abdomen, pelvis, knee, and feet etc.", "In some MRI systems some settings for a predetermined set of landmarks may be preconfigured.", "The predetermined settings may include a patient position and/or bed position relative to the RF transmit coil for each landmark in the preconfigured set.", "If only one landmark is to be scanned, then the selected landmark is the single landmark to be scanned.", "The landmark may be specified by the operator, or determined automatically by the system, for example, based upon the patient-position relative to the WBC, or in some embodiments another RF transmit coil.", "For example, the landmark closest to the center of the transmit coil may be chosen as the selected landmark.", "In example embodiments, a pre-scan, image analysis, and/or operator input may be used in determining the selected landmark.", "It should be noted that the actual patient position relative to the RF transmit coil is preferable to the bed position, because how different patients are positioned on the bed may not be consistent or sufficiently similar.", "When more than one landmark is to be scanned, the system may, in sequence, choose each landmark of a desired subset of landmarks from head to toe (e.g.", "starting from the part of the body that first enters the scanning) as the selected landmark.", "Other sequences of scanning a plurality of landmarks are also contemplated as embodiments.", "At operation 208, a data structure in a memory is accessed based upon the selected landmark (e.g.", "landmark i) and the calculated BSA.", "According to an embodiment, for each of a plurality of landmarks, a table or other data structure is stored in memory.", "The table or other data structure would include, for the corresponding landmark, information relating a BSA to a power ratio.", "The power ratio PRi for the landmark i, as described above, represents, for the selected landmark, the portion of the total power delivered to the RF transmit coil that is deposited into the patient.", "The power ratio reflects the patient's loading to the RF coil (e.g., larger patient takes more power from the coil), and shows a strong linear relationship to the BSA.", "The table or other data structure may provide ai and bi, corresponding to the slope and intercept, respectively, of a linear function that relates BSA to the power ratio for the selected landmark.", "For example, the ai and bi provided by the table or other data structure for landmark i can be such that equation (4) below is true.", "PRi=aiBSA+bi (4) An example table or other data structure 700 is described in relation to FIG.", "7.FIGS.", "4-6 illustrate a technique for determining the relationship between the BSA and the power ratio.", "At operation 210, the power ratio (e.g.", "PRi) is calculated for the patient and the selected landmark (e.g.", "landmark i), based upon the information retrieved at operation 208 from the memory.", "Specifically, using the ai and bi retrieved from the stored table or other data structure, and using equation (4) above, the system can determine the PRi.", "At operation 212, an initial SAR is determined.", "According to embodiments, the initial SAR is determined according to equation (5) below.", "SAR = P total × PR i W t × RF   duty   cycle ( 5 ) In equation (5), Ptotal is the total power delivered to the RF transmit coil PRi is the power ratio, or that portion of Ptotal deposited into the imaging subject for the ith imaging landmark; Wt is the weight of imaging subject (patient) typically in kg.", "The RF duty cycle may be looked up from pre-stored data, calculated on the fly, or determined using a combination of pre-stored data and data calculated on the fly.", "According to some embodiments, for example, the individual pulse information may be pre-stored, but the pulse sequence information is determined based upon the looked up information.", "For example, based upon a pre-scan or other measurement, power measurements associated with certain individual pulses can be determined prior to the scan of the patient and stored to be used in calculations of the power for pulse sequences during the scanning.", "The Ptotal used in this operation may be an estimation, because scanning is not yet commenced so that the actual power delivered to the RF transmit coil can be determined.", "The Ptotal estimation may be based upon the planned pulse sequences and an estimated power for each pulse.", "The determined estimated Ptotal is used, at operation 214, to calculate a predicted SAR using equation (5).", "After calculating the predicted SAR, process 200 proceeds to operation 216.At operation 216, if, the predicted SAR calculated using equation (5) is greater than a specified SAR threshold, then the operator may be notified, and the operator may change the pulse sequence(s) and/or duty cycle etc.", "in order to lower the predicted SAR.", "After changes, the process 200 proceeds back to operation 212-216 until at operation 216, the predicted SAR is determined to be lower than the SAR threshold.", "At operation 218, the scan of the patient is commenced.", "The scan may be according to one or more predetermined pulse sequences.", "During the scan, at operation 220, information is obtained regarding the RF power transmitted from the coil.", "According to one embodiment, the transmitted power is determined based upon adjusting for cable loss from the power output from RF transmitter.", "For example, the value of the power output from the RF transmitter 34 (e.g., including RF amplifier) can be adjusted for the value of attenuation in accordance with the cable type (e.g.", "coaxial) and length.", "In other embodiments, a power meter may be used to monitor the power delivered to the RF coil.", "At operation 222, the SAR for the current stage of scanning is calculated using equation (5) and the Ptotal determined at operation 220.At operation 224, it is determined whether the calculated SAR is below the specified SAR threshold.", "If the SAR is above the threshold, then at operation 226, action may be initiated to stop the scanning or change system parameters such that the scanning is controlled to subsequently bring the SAR below the specified threshold.", "According to one embodiment, upon detecting that the SAR is above the threshold amount, the system automatically stops the scanning.", "The operator may then adjust the scanner parameters such that scanning can be recommenced with pulse sequence parameters that are expected to yield a lower SAR.", "Example adjustments may include changing the duty cycle, changing the pulse sequence, etc.", "According to another embodiment, upon detecting that the SAR is above the threshold, the system notifies the operator and provides for the operator to change scanning parameters such that the operator may then adjust the scanner parameters such that SAR is lower than the threshold.", "If, at operation 224, it is determined that the SAR is below the threshold, then the SAR is considered within safety limits, and no changes are made to the pulse sequence(s).", "For each landmark i, operations 220-226 are repeated periodically during the scanning process to ensure that the scanning is controlled in accordance with the SAR limits.", "If more than one landmark is to be scanned, then for each landmark, the operations 206-226 may be repeated.", "FIG.", "3 illustrates a flowchart of a process 300 for configuring the stored data associating the BSA and the power ratio.", "According to some embodiments, process 300 can be performed before process 200 in order to populate or create a table representing the association between BSA and power ratio.", "Operations 302-308 may be performed and/or controlled by MRI data processor 42 shown in FIG.", "1.After entering the process 300, at operation 302, for each landmark j=1 .", ".", ".", "n, the system obtains data points associating a plurality of BSA with corresponding power ratios.", "In some embodiments, the data points are obtained experimentally.", "For example, a plurality of volunteer patients may be subjected to experimental scanning to determine respective power ratios associated with each patient.", "For each patient, his or her weight and height information may be used to calculate an individualized BSA.", "The experimental data may be collected, for example, using a current sensing loop (e.g., a loop wire with 1-3 cm diameter, FIG.", "8) placed in the proximity of RF coil elements.", "The sensing loop detects the B1 magnetic field which is proportional to current flow in the RF transmit coil of interest (e.g.", "WBC).", "The current loop may be connected to an oscilloscope outside of the MRI magnet room with a coaxial cable.", "A schematic drawing of the current sensing loop is shown in FIG.", "8.In order to determine the power of the coil when it is not loaded, an oil phantom can be placed at the center of the magnet, and a chosen pulse sequence performed.", "The forward and reflected peak power for a given RF pulse, and peak-to-peak voltages corresponding to this specific pulse can be simultaneously recorded from the oscilloscope.", "In order to determine the power output by the coil when it is loaded, the oil cube can be replaced with other imaging subjects (e.g., phantoms or patients) and the measurements repeated.", "When the RF transmit coil, for example, the WBC, is not loaded, the total power is equal to the coil power consumption.", "Pradiationloss=Poil_cube=Poil_cube8×RWBC (6) where Poil_cube is the overall current flow on the coil and RWBC is the resistance including all WBC loss avenues (e.g., loss on all copper elements, cables, lumped elements and radiation loss).", "When a lossy imaging subject (e.g., phantom or patient) is scanned, part of the total input power Ptotal is deposited into the imaging subject (Psub) and the rest is dissipated by the coil (Pcoil, loaded): Ptotal=Psub+Pcoil,loaded (7) The power ratio is then PR = P sub P total × 100  % ( 8 ) Since P coil , loaded = I sub 2 × R WBC = ( I sub I oil   cube ) 2 × P oil   cube , and the ratio I sub I oil   cube can be measured by a current sensing loop placed near coil elements, the power ratio can be determined as: PR = 1 - ( I sub I oil   cube ) 2 × ( P oil   cube P total ) = 1 - ( V sub V oil   cube ) 2 × ( P oil   cube P total ) ( 9 ) where Vsub and Voil_cube are voltages recorded by the current sensing loop when imaging subject and oil cube are scanned respectively.", "Poilcube and Ptotal can be calculated with forward and reflected power measured by the scanner.", "According to another embodiment, the data points are determined by simulation.", "In yet another embodiment, some of the data points are experimentally determined, and the others are determined by simulation.", "At operation 304, linear fit is performed for the data points.", "FIG.", "4 illustrates an example chart 400 in which the data points associating BSA with the power ratio for one imaging landmark are plotted.", "In chart 400, the BSA is represented on the x-axis and the PR is represented on the y-axis.", "Each data point represents a different human subject.", "In chart 400, a single best-fit line 402 can be found that is within a small distance of each of the data points.", "Any technique to find a best fit, such as, for example, the least squares technique, can be used.", "In some other embodiments, the data points may be such that a single line does not fit all the data points.", "In such cases, piece-wise linear fit can be performed.", "Piece-wise linear fit may be more accurate in relating the BSA to the power ratio for landmarks for which a wide variation exists between patients of different sizes.", "The line 402 and/or the corresponding linear equation of the form of equation (4) represents the linear relationship between BSA and the power ratio for the particular landmark.", "The inventors have found a linear relationship between the BSA and the power ratio over numerous experimental measurements and simulations.", "This linear relationship between the BSA and the power ratio is consistent with the linear correlation observed by Murbach et al.", "between the SAR and selected anatomical features such as the BSA.", "See Murbach et al., “Whole-Body and Local RF Absorption in Human Models as a Function of Anatomy and Position within 1.5 T MR Body Coil”, Magnetic Resonance in Medicine 71:839-845(2014).", "At operation 306, a safety margin is added to the linear fits.", "The safety margin exists to reduce the likelihood that the SAR thresholds are exceeded during the scanning process.", "According to some embodiments, the safety margin is determined so as to cover the measurement error and human subject variations.", "The safety-margin enhanced line can be represented as a linear equation, or set of two or more linear equations if piece-wise linear fit is performed on the data points.", "FIG.", "5 illustrates a chart 500 in which the original linear fit line 502 (in this example, line 502 is the same as line 402) and a linear fit line 504 obtained by shifting line 502 to include a safety-margin is shown.", "As illustrated graphically, it is necessary to define the safety-margin enhanced line 504 to include all data points.", "In chart 500, for example, data point 506 which appears to be an outlier (e.g., outside a certain range relative to the majority of data points) compared to all other data points is also included when the safety-margin enhanced line 504 is defined.", "The error margin that is added can be determined based upon the coil power ratio as represented in equation (9) above.", "For example, differentiating equation (9) yields the error in the power ratio measurements, as shown in equation (10) below.", "δ   PR = [ ( ∂ PR ∂ V sub ) × δ   V sub ] 2 + [ ( ∂ PR ∂ V oil   cube ) × δ   V oil   cube ] 2 + [ ( ∂ PR ∂ P oil   cube ) × δ   P oil   cube ] 2 + [ ( ∂ PR ∂ P total ) × δ   P total ] 2 = ( P oil   cube P total ) × ( V sub V oil   cube ) 2 × ( δ   P oil   cube P oil   cube ) 2 + ( δ   P total P total ) 2 + 4  ( δ   V oil   cube V oil   cube ) 2 + 4  ( δ   V sub V sub ) 2 ( 10 ) FIG.", "6 illustrates an example of a landmark for which the best fit for the BSA versus power ratio data points is achieved with more than one line.", "In the example 600 shown, a first line 602 is determined based upon a line-fit and added safety margin for lower BSA values, and a second line 604 for the data points corresponding to higher BSA values.", "In some embodiments, 2-3 separate line-fits over respective BSA ranges may be required in order to achieve a best fit.", "Separate experiments and/or numerical electromagnetic simulations can be utilized to determine power and voltage measurement errors.", "As shown by equation (10), power ratio measurement error is case by case: it depends on the actual measured power and voltage values as well as power and voltage measurement errors.", "When experimental data is plotted, error bars can be included and used as reference for setting safety margins.", "At operation 308, information associating the BSA with the power ratio are stored in a table or other data structure in a memory for each landmark.", "According to some embodiments, a separate table is stored for each landmark.", "The table stores the slope and intercept of the one or more linear equations that relate the BSA to the power ratio.", "In some embodiments, the information for more than one landmark may be stored together.", "Table 700 of FIG.", "7, for example, has a plurality of columns with each column representing a respective landmark.", "Two rows of table 700 contains the slope and intercept values for each of the landmarks.", "In some embodiments, a self-correction against operator error may be performed.", "For example, as noted above in relation to equation (3), the BSA may be determined using a height-independent function (e.g., equation (3)).", "Determining the BSA using equation (3) can, in addition to making the height value irrelevant, also reduce the impact of an incorrect weight entry by the operator.", "Based upon equations (3) and (5), the SAR (for example, for the WBC) can be approximated to Ptotal×BSA/Wt, or considered proportional to Wt−0.3534.Given the above, if the operator incorrectly enters twice the patient's weight as the weight, whereas many conventional systems would underestimate the SAR by 50% (e.g., see equation (1)), embodiments would underestimate by the much smaller 22%.", "While certain embodiments have been described, these embodiments have been presented by way of example only and are not intended to limit the scope of the inventions.", "Indeed, the novel embodiments described herein may be embodied in a variety of other forms; furthermore, various omissions, substitutions and changes in the form of the embodiments described herein may be made without departing from the spirit of the inventions.", "The accompanying claims and their equivalents are intended to cover such forms or modifications as would fall within the scope and spirit of the inventions." ] ]
Patent_15874122
[ [ "LITHIUM-ION SECONDARY BATTERY AND ELECTRONIC DEVICE", "A lithium-ion secondary battery with high capacity is provided.", "Alternatively, a lithium-ion secondary battery with unproved cycle characteristics is provided.", "To achieve this, an active material including a particle having a cleavage plane and a layer containing carbon covering at least part of the cleavage plane is provided.", "The particle having the cleavage plane contains lithium, manganese, nickel, and oxygen.", "The layer containing carbon preferably contains graphene.", "When a lithium-ion secondary battery is fabricated using an electrode including the particle having the cleavage plane at least part of which is covered with the layer containing carbon as an active material, the discharge capacity can be increased and the cycle characteristics can be improved." ], [ "1.", "(canceled) 2.A method for forming an active material, comprising the steps of: forming a mixture of a lithium compound, a manganese compound, and a nickel compound; heating the mixture and obtaining a secondary particle composed of sintered primary particles; crushing the secondary particle into a plurality of particles; and coating the plurality of particles with a layer comprising graphene, wherein a first cleavage plane of a first particle in the plurality of particles is covered with the layer comprising graphene.", "3.The method for forming the active material according to claim 2, wherein the heating step is performed at higher than or equal to 800° C. and lower than or equal to 1000° C. 4.The method for forming the active material according to claim 2, wherein the crushing step is performed using a bead mill.", "5.The method for forming the active material according to claim 2, wherein a particle size of the plurality of particles is substantially the same as a particle size of the sintered primary particles.", "6.The method for forming the active material according to claim 2, wherein a second cleavage plane of a second particle in the plurality of particles is covered with the layer comprising graphene, and wherein the first particle and the second particle are bound with graphene.", "7.The method for forming the active material according to claim 2, wherein the first cleavage plane is formed by the crushing step.", "8.A method for forming an active material, comprising the steps of: forming a mixture of a lithium compound and a cobalt compound; heating the mixture and obtaining a secondary particle composed of sintered primary particles; crushing the secondary particle into a plurality of particles; and coating the plurality of particles with a layer comprising graphene, wherein a first cleavage plane of a first particle in the plurality of particles is covered with the layer comprising graphene.", "9.The method for forming the active material according to claim 8, wherein the heating step is performed at higher than or equal to 800° C. and lower than or equal to 1000° C. 10.The method for forming the active material according to claim 8, wherein the crushing step is performed using a bead mill.", "11.The method for forming the active material according to claim 8, wherein a particle size of the plurality of particles is substantially the same as a particle size of the sintered primary particles.", "12.The method for forming the active material according to claim 8, wherein a second cleavage plane of a second particle in the plurality of particles is covered with the layer comprising graphene, and wherein the first particle and the second particle are bound with graphene.", "13.The method for forming the active material according to claim 8, wherein the first cleavage plane is formed by the crushing step.", "14.A method for forming an active material, comprising the steps of: forming a mixture of a lithium compound, a manganese compound, and a nickel compound; heating the mixture and obtaining a secondary particle composed of sintered primary particles; crushing the secondary particle into a plurality of particles; kneading the plurality of particles and graphene oxide; reducing the graphene oxide on the plurality of particles and coating the plurality of particles with a layer comprising graphene, wherein a first cleavage plane of a first particle in the plurality of particles is covered with the layer comprising graphene.", "15.The method for forming the active material according to claim 14, wherein the heating step is performed at higher than or equal to 800° C. and lower than or equal to 1000° C. 16.The method for forming the active material according to claim 14, wherein the crushing step is performed using a bead mill.", "17.The method for forming the active material according to claim 14, wherein a particle size of the plurality of particles is substantially the same as a particle size of the sintered primary particles.", "18.The method for forming the active material according to claim 14, wherein a second cleavage plane of a second particle in the plurality of particles is covered with the layer comprising graphene, and wherein the first particle and the second particle are bound with graphene.", "19.The method for forming the active material according to claim 14, wherein the first cleavage plane is formed by the crushing step." ], [ "<SOH> BACKGROUND ART <EOH>In recent years, portable electronic devices such as smartphones and tablets have spread rapidly.", "Also with growing interest in the environment, hybrid cars and electric cars have attracted attention, thereby increasing the importance of secondary batteries.", "Examples of the secondary batteries include a nickel-metal hydride battery, a lead-acid battery, and a lithium-ion secondary battery.", "In particular, lithium-ion secondary batteries have been actively developed because the capacity thereof can be increased and the size thereof can be reduced.", "A basic secondary battery includes a positive electrode, a negative electrode, and an electrolyte (an electrolyte solution or a solid electrolyte) provided therebetween.", "Typically, the positive electrode and the negative electrode each include a current collector and an active material layer provided over the current collector.", "In the case of a lithium-ion secondary battery, a material capable of receiving and releasing lithium ions is used as an active material for a positive electrode and a negative electrode.", "As examples of positive electrode active materials of a lithium-ion secondary battery, phosphate compounds disclosed in Patent Document 1, such as lithium iron phosphate (LiFePO 4 ), lithium manganese phosphate (LiMnPO 4 ), lithium cobalt phosphate (LiCoPO 4 ), and lithium nickel phosphate (LiNiPO 4 ), each having an olivine structure and containing lithium (Li) and iron (Fe), manganese (Mn), cobalt (Co), or nickel (Ni) are known" ], [ "<SOH> BRIEF DESCRIPTION OF DRAWINGS <EOH>FIG.", "1 is a flow chart illustrating a method for forming an active material.", "FIG.", "2A is a schematic diagram of sintered lithium-manganese composite oxides, FIG.", "2B is a schematic diagram of cleaved lithium-manganese composite oxides, and FIG.", "2C is a schematic diagram of lithium-manganese composite oxides each covered with a layer containing carbon.", "FIGS.", "3A and 3B are schematic diagrams illustrating an electrode.", "FIG.", "4 illustrates a thin storage battery.", "FIGS.", "5A and 5B are each a cross-sectional view of a storage battery.", "FIGS.", "6A and 6B are each a diagram for illustrating a thin storage battery.", "FIGS.", "7A and 7B are each a diagram for illustrating a thin storage battery.", "FIG.", "8 is a diagram for illustrating a thin storage battery.", "FIGS.", "9A to 9C are each a diagram for illustrating a radius of curvature of a surface.", "FIGS.", "10A to 10D are each a diagram for illustrating a radius of curvature of a film.", "FIGS.", "11A and 11B illustrate a coin-type storage battery.", "FIGS.", "12A and 12B illustrate a cylindrical storage battery.", "FIGS.", "13A to 13C illustrate an example of a power storage device.", "FIGS.", "14A to 14C illustrate an example of a power storage device.", "FIGS.", "15A and 15B illustrate an example of a power storage device.", "FIGS.", "16 A 1 , 16 A 2 , 16 B 1 , and 16 B 2 each illustrate an example of a power storage device.", "FIGS.", "17A and 17B each illustrate an example of a power storage device.", "FIGS.", "18A to 18G each illustrate an example of an electronic device.", "FIGS.", "19A to 19C illustrate an example of an electronic device.", "FIG.", "20 illustrates examples of electronic devices.", "FIGS.", "21A and 21B illustrate an example of an electronic device.", "FIG.", "22 shows a cross-sectional TEM observation result of lithium-manganese composite oxides.", "FIGS.", "23A and 23B each show a cross sectional TEM observation result of a lithium-manganese composite oxide.", "FIGS.", "24A and 24B show a cross-sectional TEM observation result and an electron diffraction result of a lithium-manganese composite oxide.", "FIG.", "25 shows a STEM observation result of an active material, FIG.", "26 shows an EELS analysis result of an active material.", "FIG.", "27 shows an EELS analysis result of an active material.", "FIG.", "28 shows an EELS analysis result of an active material.", "FIG.", "29A shows a STEM observation result of an active material and FIG.", "29B shows EELS linear analysis results of the active material.", "FIGS.", "30A and 30B each show discharge capacity associated with charge and discharge cycles.", "FIG.", "31 shows charge and discharge characteristics after the fifth cycle.", "FIG.", "32 shows discharge capacity associated with charge and discharge cycles.", "FIGS.", "33A and 33B show XAFS measurement results of lithium-manganese composite oxides.", "FIGS.", "34A and 34B show XAFS measurement results of lithium-manganese composite oxides.", "FIG.", "35 illustrates a crystal structure of Li 2 MnO 3 .", "FIG.", "36 is a graph showing Li position dependence of energy at the time of Li deintercalation.", "FIG.", "37A illustrates differential charge density of Structure 2 and FIG.", "37B illustrates differential charge density of Structure 2 (seen from the b-axis direction).", "FIG.", "38 illustrates differential charge density of Structure 3.FIG.", "39 illustrates a unit cell of Li 2 MnO 3 .", "FIG.", "40 is a graph showing calculation results of formation energy of an oxygen vacancy.", "FIG.", "41 shows a cross-sectional TEM observation result of an active material.", "FIG.", "42A shows a TEM observation result of an active material and FIG.", "42B shows a Fourier transform diffraction pattern.", "FIG.", "43 shows a cross-sectional TEM observation result of an active material.", "FIG.", "44A shows a TEM observation result of an active material and FIG.", "44B shows a Fourier transform diffraction pattern.", "FIG.", "45 shows measurement results of the rate characteristics of a cell of Example.", "FIG.", "46 shows measurement results of the temperature characteristics of a cell of Example.", "FIG.", "47 shows a SEM observation result of an active material of Example.", "FIG.", "48 shows the cycle characteristics of cells of Example.", "FIG.", "49 illustrates a spray dryer.", "FIG.", "50 shows the cycle characteristics of a cell of Example.", "FIG.", "51 shows the charge and discharge characteristics of a cell of Example.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "TECHNICAL FIELD The present invention relates to an object, a method, or a manufacturing method.", "The present invention relates to a process, a machine, manufacture, or a composition of matter.", "In particular, one embodiment of the present invention relates to a semiconductor device, a display device, a light-emitting device, a power storage device, a storage device, a driving method thereof, or a manufacturing method thereof.", "In particular, one embodiment of the present invention relates to a structure of a secondary battery and a method for manufacturing the secondary battery.", "One embodiment of the present invention particularly relates to a positive electrode active material of a lithium-ion secondary battery.", "BACKGROUND ART In recent years, portable electronic devices such as smartphones and tablets have spread rapidly.", "Also with growing interest in the environment, hybrid cars and electric cars have attracted attention, thereby increasing the importance of secondary batteries.", "Examples of the secondary batteries include a nickel-metal hydride battery, a lead-acid battery, and a lithium-ion secondary battery.", "In particular, lithium-ion secondary batteries have been actively developed because the capacity thereof can be increased and the size thereof can be reduced.", "A basic secondary battery includes a positive electrode, a negative electrode, and an electrolyte (an electrolyte solution or a solid electrolyte) provided therebetween.", "Typically, the positive electrode and the negative electrode each include a current collector and an active material layer provided over the current collector.", "In the case of a lithium-ion secondary battery, a material capable of receiving and releasing lithium ions is used as an active material for a positive electrode and a negative electrode.", "As examples of positive electrode active materials of a lithium-ion secondary battery, phosphate compounds disclosed in Patent Document 1, such as lithium iron phosphate (LiFePO4), lithium manganese phosphate (LiMnPO4), lithium cobalt phosphate (LiCoPO4), and lithium nickel phosphate (LiNiPO4), each having an olivine structure and containing lithium (Li) and iron (Fe), manganese (Mn), cobalt (Co), or nickel (Ni) are known REFERENCE Patent Document [Patent Document 1] Japanese Published Patent Application No.", "H11-025983 DISCLOSURE OF INVENTION An object of one embodiment of the present invention is to provide a power storage device with high capacity.", "Another object of one embodiment of the present invention is to provide a power storage device with improved cycle characteristics.", "Another object of one embodiment of the present invention is to provide a highly reliable power storage device.", "Another object of one embodiment of the present invention is to provide a long-life power storage device.", "Another object of one embodiment of the present invention is to increase a yield of a power storage device.", "Another object of one embodiment of the present invention is to provide a novel power storage device, a novel electrode, a novel active material, or the like.", "Note that the description of these objects does not preclude the existence of other objects.", "In one embodiment of the present invention, there is no need to achieve all the objects.", "Other objects will be apparent from and can be derived from the description of the specification, the drawings, the claims, and the like.", "In one embodiment of the present invention, an active material including a particle having a cleavage plane and a layer containing carbon covering at least part of the cleavage plane of the particle is provided.", "The particle having the cleavage plane contains lithium, manganese, nickel, and oxygen.", "The layer containing carbon includes graphene.", "The thickness of the layer containing carbon is preferably greater than or equal to 1 nm and less than or equal to 50 nm.", "The particle having the cleavage plane has a layered rock-salt crystal structure.", "Alternatively, the particle having the cleavage plane has a layered rock-salt crystal structure and a spinel crystal structure.", "The cleavage plane of the particle having a layered rock-salt crystal structure has a crystal plane of a (001) plane or a (100) plane.", "An electrode including the active material of one embodiment of the present invention has a charge/discharge capacity of greater than or equal to 260 mAh/g in the first 15 cycles with an oxidation-reduction potential of Li used as a reference potential and a voltage range of higher than or equal to 2.0 V and lower than or equal to 4.8 V. In another embodiment of the present invention, an electrode including a current collector and an active material layer containing the active material, a conductive additive, and a binder is provided.", "In another embodiment of the present invention, a lithium-ion secondary battery including a first electrode containing the active material and a second electrode is provided.", "The first electrode is capable of operating as one of a positive electrode and a negative electrode, and the second electrode is capable of operating as the other of the positive electrode and the negative electrode.", "One embodiment of the present invention can provide a power storage device with high capacity.", "One embodiment of the present invention can provide a power storage device with improved cycle characteristics.", "One embodiment of the present invention can provide a highly reliable power storage device.", "One embodiment of the present invention can provide a power storage device with a long lifetime.", "According to one embodiment of the present invention, a yield of a power storage device can be increased.", "According to one embodiment of the present invention, a novel power storage device, a novel electrode, a novel active material, or the like can be provided.", "Note that the description of these effects does not preclude the existence of other effects.", "In one embodiment of the present invention, there is no need to obtain all the effects.", "Other effects will be apparent from and can be derived from the description of the specification, the drawings, the claims, and the like.", "BRIEF DESCRIPTION OF DRAWINGS FIG.", "1 is a flow chart illustrating a method for forming an active material.", "FIG.", "2A is a schematic diagram of sintered lithium-manganese composite oxides, FIG.", "2B is a schematic diagram of cleaved lithium-manganese composite oxides, and FIG.", "2C is a schematic diagram of lithium-manganese composite oxides each covered with a layer containing carbon.", "FIGS.", "3A and 3B are schematic diagrams illustrating an electrode.", "FIG.", "4 illustrates a thin storage battery.", "FIGS.", "5A and 5B are each a cross-sectional view of a storage battery.", "FIGS.", "6A and 6B are each a diagram for illustrating a thin storage battery.", "FIGS.", "7A and 7B are each a diagram for illustrating a thin storage battery.", "FIG.", "8 is a diagram for illustrating a thin storage battery.", "FIGS.", "9A to 9C are each a diagram for illustrating a radius of curvature of a surface.", "FIGS.", "10A to 10D are each a diagram for illustrating a radius of curvature of a film.", "FIGS.", "11A and 11B illustrate a coin-type storage battery.", "FIGS.", "12A and 12B illustrate a cylindrical storage battery.", "FIGS.", "13A to 13C illustrate an example of a power storage device.", "FIGS.", "14A to 14C illustrate an example of a power storage device.", "FIGS.", "15A and 15B illustrate an example of a power storage device.", "FIGS.", "16A1, 16A2, 16B1, and 16B2 each illustrate an example of a power storage device.", "FIGS.", "17A and 17B each illustrate an example of a power storage device.", "FIGS.", "18A to 18G each illustrate an example of an electronic device.", "FIGS.", "19A to 19C illustrate an example of an electronic device.", "FIG.", "20 illustrates examples of electronic devices.", "FIGS.", "21A and 21B illustrate an example of an electronic device.", "FIG.", "22 shows a cross-sectional TEM observation result of lithium-manganese composite oxides.", "FIGS.", "23A and 23B each show a cross sectional TEM observation result of a lithium-manganese composite oxide.", "FIGS.", "24A and 24B show a cross-sectional TEM observation result and an electron diffraction result of a lithium-manganese composite oxide.", "FIG.", "25 shows a STEM observation result of an active material, FIG.", "26 shows an EELS analysis result of an active material.", "FIG.", "27 shows an EELS analysis result of an active material.", "FIG.", "28 shows an EELS analysis result of an active material.", "FIG.", "29A shows a STEM observation result of an active material and FIG.", "29B shows EELS linear analysis results of the active material.", "FIGS.", "30A and 30B each show discharge capacity associated with charge and discharge cycles.", "FIG.", "31 shows charge and discharge characteristics after the fifth cycle.", "FIG.", "32 shows discharge capacity associated with charge and discharge cycles.", "FIGS.", "33A and 33B show XAFS measurement results of lithium-manganese composite oxides.", "FIGS.", "34A and 34B show XAFS measurement results of lithium-manganese composite oxides.", "FIG.", "35 illustrates a crystal structure of Li2MnO3.FIG.", "36 is a graph showing Li position dependence of energy at the time of Li deintercalation.", "FIG.", "37A illustrates differential charge density of Structure 2 and FIG.", "37B illustrates differential charge density of Structure 2 (seen from the b-axis direction).", "FIG.", "38 illustrates differential charge density of Structure 3.FIG.", "39 illustrates a unit cell of Li2MnO3.FIG.", "40 is a graph showing calculation results of formation energy of an oxygen vacancy.", "FIG.", "41 shows a cross-sectional TEM observation result of an active material.", "FIG.", "42A shows a TEM observation result of an active material and FIG.", "42B shows a Fourier transform diffraction pattern.", "FIG.", "43 shows a cross-sectional TEM observation result of an active material.", "FIG.", "44A shows a TEM observation result of an active material and FIG.", "44B shows a Fourier transform diffraction pattern.", "FIG.", "45 shows measurement results of the rate characteristics of a cell of Example.", "FIG.", "46 shows measurement results of the temperature characteristics of a cell of Example.", "FIG.", "47 shows a SEM observation result of an active material of Example.", "FIG.", "48 shows the cycle characteristics of cells of Example.", "FIG.", "49 illustrates a spray dryer.", "FIG.", "50 shows the cycle characteristics of a cell of Example.", "FIG.", "51 shows the charge and discharge characteristics of a cell of Example.", "BEST MODE FOR CARRYING OUT THE INVENTION Embodiments and examples of the present invention will be described below in detail with reference to the drawings.", "However, the present invention is not limited to the description below, and it is easily understood by those skilled in the art that modes and details disclosed herein can be modified in various ways.", "Furthermore, the present invention is not construed as being limited to the description of the embodiments and examples.", "Embodiment 1 In this embodiment, an active material of one embodiment of the present invention and a formation method thereof will be described with reference to FIG.", "1 and FIGS.", "2A to 2C.", "An active material of one embodiment of the present invention includes a particle having a cleavage plane and a layer containing carbon covering at least part of the cleavage plane.", "The particle having the cleavage plane contains at least lithium, manganese, and oxygen.", "The particle having the cleavage plane may further contain at least one element selected from chromium, cobalt, aluminum, nickel, iron, magnesium, molybdenum, zinc, indium, gallium, copper, titanium, niobium, silicon, phosphorus, and the like.", "Note that an active material generally refers only to a material that relates to intercalation and deintercalation of ions functioning as carriers; however, an active material described in this specification and the like also includes a layer containing carbon that covers a general “active material.” In this specification and the like, “cleavage” means cracking of a crystal along a specific direction, a “cleavage plane” refers to a crystal plane made by cleavage, and a “cleavage property” means a property of easy cracking along a specific direction.", "An example of the particle having the cleavage plane is a lithium-manganese composite oxide represented by a composition formula LixMnyMzOw.", "Thus, the lithium-manganese composite oxide represented by the composition formula LixMnyMzOw will be described as an active material in this embodiment.", "Here, the element M is preferably silicon, phosphorus, or a metal element other than lithium and manganese.", "Furthermore, it is preferable that 0≤x/(y+z)<2, z>0, and 0.26≤(y+z)/w<0.5 be satisfied.", "Note that the lithium-manganese composite oxide is an oxide containing at least lithium and manganese, and may contain at least one selected from chromium, cobalt, aluminum, nickel, iron, magnesium, molybdenum, zinc, indium, gallium, copper, titanium, niobium, silicon, phosphorus, and the like.", "The lithium-manganese composite oxide preferably has a layered rock-salt crystal structure.", "The lithium-manganese composite oxide may have a layered rock-salt crystal structure and a spinel crystal structure.", "The average particle diameter of the lithiums-manganese composite oxides is preferably greater than or equal to 5 nm and less than or equal to 50 μm, for example.", "Note that a “layered rock-salt crystal structure” in this specification and the like refers to a crystal structure in which a lithium layer and a layer containing lithium and a metal are alternately stacked with an oxygen layer provided therebetween, that is, a crystal structure in which a layer containing a metal ion and lithium and a lithium layer are alternately stacked with an oxide ion provided therebetween.", "A synthesis method of the lithium-manganese composite oxide represented by the composition formula LixMnyMzOw will be described.", "A manganese compound and a lithium compound can be used as raw materials of the lithium-manganese composite oxide.", "In addition to the manganese compound and the lithium compound, a compound containing at least one selected from chromium, cobalt, aluminum, nickel, iron, magnesium, molybdenum, zinc, indium, gallium, copper, titanium, niobium, silicon, phosphorus, and the like can be used as a raw material.", "Examples of the manganese compound arc manganese dioxide, manganese sesquioxide, trimanganese tetroxide, hydrous manganese oxide, manganese carbonate, and manganese nitrate.", "Examples of the lithium compound are lithium hydroxide, lithium carbonate, and lithium nitrate.", "In this embodiment, MnCO3 (manganese compound), Li2CO3 (lithium compound), and NiO are used as starting materials.", "First, Li2CO3, MnCO3, and NiO are each weighed as a starting material as shown in Step S11 in FIG.", "1.In the case where Li2CO3, MnCO3, and NiO are used as starting materials at a ratio for weighing (molar ratio) of 1:0.7:0.3, for example, a lithium-manganese composite oxide Li2Mn0.7Ni0.3O3 is formed as a final product.", "In this case, the atomic ratio of Li to (Mn+Ni) in the lithium-manganese composite oxide is 2:1.In one embodiment of the present invention, the ratio for weighing (molar ratio) of the starting materials is adjusted so that the atomic ratio of Li to (Mn+Ni) in the lithium-manganese composite oxide becomes slightly different from 2:1.In this embodiment, the starting materials are weighed so that the ratio for weighing (molar ratio) of Li2CO3 to MnCO3 and NiO becomes 0.84:0.8062:0.318.Next, Li2CO3, MnCO3, and NiO are mixed as shown in Step S12 in FIG.", "1.There is no particular limitation on a method for mixing the starting materials, and a known crusher or a known mill such as a ball mill, a bead mill, a jet mill, or a roller mill can be used.", "A crushing and grinding method may be a dry method or a wet method.", "There is no particular limitation on a solvent that is used in a wet method, and water, alcohol, or acetone can be used as the solvent, for example.", "When the starting materials are mixed by a wet method, heat treatment shown in Step S13 in FIG.", "1 for evaporating a solvent contained in the mixed starting materials is performed.", "The heat treatment is performed at higher than or equal to 50° C. and lower than or equal to 150° C. The solvent used when the starting materials are crushed and grinded is evaporated by the heat treatment, whereby a mixed material is obtained.", "Then, the mixed material is put in a crucible and firing shown in Step S14 in FIG.", "1 is performed at higher than or equal to 800° C. and lower than or equal to 1000° C. The firing is performed for longer than or equal to 5 hours and shorter than or equal to 20 hours in an air gas (dry air) at a flow rate of 10 L/min, for example.", "The firing atmosphere may be an air atmosphere or an atmosphere containing an oxygen gas.", "Owing to the firing of the mixed material, primary particles (lithium-manganese composite oxides) are formed and the primary particles are sintered to be a large secondary particle.", "FIG.", "2A illustrates a large secondary particle in which a plurality of primary particles 110 to 112 are sintered.", "Next, crushing treatment shown in Step S15 in FIG.", "1 is performed on the large secondary particle in which a plurality of primary particles are sintered, so that the large secondary particle is crushed into the primary particles or powder of particles as small as the primary particles.", "The crushing treatment in this specification and the like includes an operation of grinding the primary particles.", "Note that grinding means further crushing of the primary particles.", "As in the case of mixing the starting materials, a known crusher or a known mill can be used for the crushing treatment.", "A crushing and grinding method may be a dry method or a wet method.", "There is no particular limitation on a solvent that is used in a wet method, and water, alcohol, or acetone can be used as the solvent, for example.", "The large secondary particle in which a plurality of primary particles are sintered is preferably subjected to the crushing treatment because the specific surface area of the particles is increased after the crushing treatment.", "In this embodiment, the crushing treatment of the large secondary particle in which a plurality of primary particles are sintered is performed with a bead mill by a wet method using acetone.", "When the crushing treatment is performed by a wet method, heat treatment for evaporating a solvent is performed after the crushing treatment.", "The heat treatment may be performed in a manner similar to that of the heat treatment in Step S13.After that, vacuum drying is performed, whereby powdery lithium-manganese composite oxide is obtained.", "The crystallinity of the lithium-manganese composite oxide subjected to the crushing treatment might be disordered by the impact of the crushing treatment.", "In addition, oxygen vacancies might be formed in the lithium-manganese composite oxide.", "Thus, heat treatment is preferably performed on the powdery lithium-manganese composite oxide subjected to the vacuum drying.", "The heat treatment shown in Step S16 in FIG.", "1 is performed in the following manner: the lithium-manganese composite oxides subjected to the crushing treatment are put in a crucible and heated at higher than or equal to 300° C. and lower than or equal to 1000° C., preferably higher than or equal to 600° C. and lower than or equal to 900° C. The heat treatment is performed for longer than or equal to 5 hours and shorter than or equal to 20 hours in an air gas (dry air) at a flow rate of 10 L/min, for example.", "The atmosphere may be an air atmosphere or an atmosphere containing an oxygen gas.", "The heat treatment performed on the lithium-manganese composite oxides subjected to the crushing treatment can repair oxygen vacancies and compensate the crystal disorder caused by the impact of the crushing treatment.", "Note that another crushing treatment may be performed on the powdery lithium-manganese composite oxide subjected to the heat treatment, in which case the crushing treatment can be performed in a manner similar to that of the crushing treatment in Step S15 in FIG.", "1.Though the above steps, the lithium-manganese composite oxide represented by the composition formula LixMnyMzOw can be formed.", "In this embodiment, the raw materials are weighed so that the ratio for weighing (molar ratio) of Li2CO3 to MnCO3 and NiO becomes 0.84:0.8062:0318, whereby a lithium-manganese composite oxide represented by a composition formula Li1.68Mn0.8062M0.318O3 can be formed.", "The atomic ratio of Li to (Mn+Ni) in the lithium-manganese composite oxide described in this embodiment is adjusted to be slightly different from 2:1.Thus, voltage and discharge capacity are large as compared with the case where a lithium-manganese composite oxide whose atomic ratio of Li to (Mn+Ni) is 2:1 is used for an electrode.", "In a method for forming the lithium-manganese composite oxide, a crushing step of a secondary particle in which primary particles are sintered is important because the step influences the characteristics of a battery.", "In the crushing step, a shear (grinding stress) is applied to the secondary particle in which the primary particles are sintered, whereby a powdery lithium-manganese composite oxide is formed.", "In the case where the lithium-manganese composite oxide has a layered rock-salt crystal structure, a primary particle might be cleaved and cracked along a plane parallel or perpendicular to the layer at this time.", "The cleaved and cracked primary particle is called a particle having a cleavage plane or a particle with a cleavage plane exposed, in this specification and the like.", "Note that some primary particles do not have a cleavage plane.", "FIG.", "2B illustrates particles 110a and 110b into which the primary particle 110 is cleaved, and particles 111a and 111b into which the primary particle 111 is cleaved.", "An active material having a cleavage property, such as the lithium-manganese composite oxide having a layered rock-salt crystal structure, might be cracked not only in the crushing step but also in a formation process of an electrode because a pressure is applied to an active material layer when the electrode is pressurized.", "When a wound battery is formed, a great stress is caused at the time of winding an electrode.", "Even when a wound body of the electrode is stored in a housing, the active material might be further cracked because an outward stress from an axis of winding is caused all the time.", "Such cleavage and cracking of the active material cause a decrease in the discharge capacity and cycle characteristics of a battery.", "Thus, in one embodiment of the present invention, a layer containing carbon is provided on at least part of a cleavage plane of a lithium-manganese composite oxide.", "The layer containing carbon may cover the entire cleavage plane or the whole lithium-manganese composite oxide having a cleavage plane.", "It is preferred to use graphene as the layer containing carbon.", "Graphene has excellent electrical characteristics of high conductivity and excellent physical properties of high flexibility and high mechanical strength.", "Note that graphene in this specification includes single-layer graphene and multilayer graphene including two to hundred layers.", "Single-layer graphene refers to a one-atom-thick sheet of carbon molecules having π bonds.", "Graphene oxide refers to a compound formed by oxidation of such graphene.", "When graphene oxide is reduced to give graphene, oxygen contained in the graphene oxide is not entirely deintercalated and part of the oxygen remains in graphene.", "When graphene contains oxygen, the proportion of oxygen measured by XPS is higher than or equal to 2 atomic % and lower than or equal to 20 atomic %, preferably higher than or equal to 3 atomic % and lower than or equal to 15 atomic %.", "The thickness of the layer containing carbon provided on at least part of a cleavage plane of the lithium-manganese composite oxide is preferably greater than or equal to 1 nm and less than or equal to 50 nm.", "The lithium-manganese composite oxide has a layered rock-salt crystal structure.", "Alternatively, the lithium-manganese composite oxide of one embodiment of the present invention has a layered rock-salt crystal structure and a spinel crystal structure.", "The present inventors have found that a cleavage plane of the lithium-manganese composite oxide having a layered rock-salt crystal structure has a crystal plane of a (001) plane, a (00-1) plane, a (100) plane, a (-100) plane, a (010) plane, a (0-10) plane, a (021) plane, a (02-1) plane, a (0-21) plane, or a (0-2-1) plane.", "Thus, the layer containing carbon is preferably provided so as to be in contact with the cleavage plane of the lithium-manganese composite oxide having a crystal plane of the (001) plane, the (00-1) plane, the (100) plane, the (-100) plane, the (010) plane, the (0-10) plane, the (021) plane, the (02-1) plane, the (0-21) plane, or the (0-2-1) plane.", "Next, a method for providing the layer containing carbon on the lithium-manganese composite oxide will be described.", "In this embodiment, reduced graphene oxide (RGO) obtained by reducing graphene oxide (GO) is used as the layer containing carbon.", "Various synthesis methods such as a Hummers method, a modified Hummers method, and oxidation of graphite can be used to form graphene oxide.", "For example, in a Hummers method, graphite such as flake graphite is oxidized to give graphite oxide.", "The obtained graphite oxide is graphite that is oxidized in places and thus to which a functional group such as a carbonyl group, a carboxyl group, or a hydroxyl group is bonded.", "In the graphite oxide, the crystallinity of the graphite is lost and the distance between layers is increased.", "Therefore, graphene oxide can be easily obtained by separation of the layers from each other by ultrasonic treatment or the like.", "The length of one side (also referred to as a flake size) of the graphene oxide is greater than or equal to 50 nm and less than or equal to 100 μm, preferably greater than or equal to 800 nm and less than or equal to 20 μm.", "It is preferable that the flake size be as large as possible to cover surfaces of the lithium-manganese composite oxides with ease.", "First, graphene oxide and water are put in a mixer to form a dispersion solution of graphene oxide.", "At this time, graphene oxide at greater than or equal to 0.5 wt % and less than or equal to 5 wt % is preferably used.", "Graphene oxide at less than 0.5 wt % might be insufficient to cover the surfaces of the lithium-manganese composite oxides, whereas graphene oxide at greater than 5 wt % causes an increase in the volume and weight of the electrode.", "Next, the lithium-manganese composite oxides are put in the dispersion solution and kneading is performed as shown in Step S17 in FIG.", "1.Note that kneading means mixing something until it has a high viscosity.", "The kneading can separate aggregation of lithium manganese composite oxide powder; thus, the graphene oxide and the lithium manganese composite oxides can be uniformly dispersed.", "Then, the mixture of the graphene oxide and the lithium-manganese composite oxides is dried under reduced pressure in a bell jar and then is ground in a mortar, so that the lithium manganese composite oxides covered with graphene oxide is obtained.", "Subsequently, reduction treatment is performed on the graphene oxide covering the surfaces of the lithium-manganese composite oxides as shown in Step S18 in FIG.", "1.The reduction treatment of the graphene oxide may be performed by heat treatment or by causing a reaction in a solvent containing a reducing agent.", "In this embodiment, the graphene oxide is made to react in a solvent containing a reducing agent.", "When the graphene oxide is made to react in the solvent containing the reducing agent, the graphene oxide covering the surfaces of the lithium-manganese composite oxides is reduced to give graphene.", "Note that oxygen in graphene oxide is not necessarily entirely deintercalated and may remain partly in the graphene.", "In the case where graphene contains oxygen, the proportion of oxygen in the graphene measured by XPS is higher than or equal to 2 atomic % and lower than or equal to 20 atomic %, preferably higher than or equal to 3 atomic % and lower than or equal to 15 atomic %.", "This reduction treatment is preferably performed at temperatures of room temperature to 150° C., more preferably at temperatures of room temperature to 80° C. The reduction treatment with heating can promote the reduction reaction.", "The reduction time of the graphene oxide can be longer than or equal to 3 minutes and shorter than or equal to 10 hours.", "Examples of the reducing agent include ascorbic acid, hydrazine, dimethyl hydrazine, hydroquinone, sodium boron hydride (NaBH4), tetra butyl ammonium bromide (TBAB), lithium aluminum hydride (LiAlH4), N,N-diethylhydroxylamine, and a derivative thereof.", "For example, ascorbic acid and hydroquinone are preferable to hydrazine and sodium tetrahydroborate in that they are safe owing to low reducing ability and utilized industrially with ease.", "A polar solvent can be used as the solvent.", "Any material can be used for the solvent as long as it can dissolve the reducing agent.", "Examples of the material of the solvent include water, methanol, ethanol, acetone, tetrahydrofuran (THF), dimethylformamide (DMF), 1-methyl-2-pyrrolidone (NMP), dimethyl sulfoxide (DMSO), ethylene glycol, diethylene glycol, glycerin, and a mixed solution of any two or more of the above.", "As the reducing solution containing a reducing agent and a solvent, a mixed solution of ethanol and ascorbic acid, or a mixed solution of water, ascorbic acid, and lithium hydroxide can be used.", "In this embodiment, a reducing solution containing ascorbic acid, water, and lithium hydroxide is used.", "When the graphene oxide covering the lithium-manganese composite oxides is made to react in the reducing solution, protons of ascorbic acid are added to the graphene oxide and then H2O is released, whereby the graphene oxide is reduced.", "As a result, the surfaces of the lithium-manganese composite oxides are covered with graphene.", "After the reduction treatment, the reducing solution is filtered and a substance is obtained.", "The filtration can be suction filtration or the like.", "Next, the obtained substance is washed.", "The washing is preferably performed using a solution given as the solvent contained in the reducing solution.", "The solution may be the same as or different from the solvent contained in the reducing solution.", "Then, the washed substance is dried as shown in Step S19 in FIG.", "1.The drying step preferably has two stages: predrying and main drying.", "The predrying is performed using a spray dryer device, for example.", "The spray dryer device is an apparatus which can conduct continuous drying to turn a solution into dry particles in a moment with a hot air.", "FIG.", "49 is a schematic diagram of the spray dryer device.", "A solution is sprayed in the form of fine liquid drops from a two-fluid nozzle 721, is exposed to hot air blown from a heating means 722 while increasing the surface area per unit volume, and is dried in a moment in a spray cylinder 723 to be particles.", "Then, the particles are separated by a cyclone 724, and desired powder is collected in a container 725.A tube (not illustrated) is connected to the two-fluid nozzle 721, and the solution is transferred to the two-fluid nozzle 721 with the use of a pump.", "A tube made of silicone is used as the tube, for example.", "Reference numerals 726 and 727 represent an outlet filter that removes unnecessary powder and an aspirator that makes the flow of a gas, respectively.", "Note that arrows in FIG.", "49 indicate the flow of a dry gas.", "For example, to form dispersion liquid, pure water is added to the washed substance.", "The dispersion liquid is poured into the spray dryer device illustrated in FIG.", "49, sprayed from the two-fluid nozzle 721, and dried in a moment in the spray cylinder 723.The drying is performed with nitrogen heated to 50° C. to 300° C. by the heating means 722, for example.", "Then, the particles are separated by the cyclone 724, and the desired powder is collected in the container 725.Subsequently, main drying is performed on the powder dried in the spray dryer device.", "The main drying is performed under a reduced pressure (in vacuum) or in a reduction atmosphere.", "This drying step may be performed at temperatures of 50° C. to 300° C. for 1 hour to 48 hours, for example.", "The drying allows sufficient evaporation or removal of the polar solvent and moisture.", "The drying step can also facilitate the reduction of graphene oxide.", "Although the case where the drying step includes the predrying and the main drying is described in this embodiment, one embodiment of the present invention is not limited thereto.", "The drying step may include at least one of the pre-drying and the main drying.", "Through the above steps, the graphene oxide is reduced, so that graphene can be formed on the surface of the lithium manganese composite oxides.", "As illustrated in FIG.", "2C, graphene 120a is formed so as to cover the particle 110a and graphene 120b is formed so as to cover the particle 110b.", "FIG.", "2C illustrates some examples where graphene is provided on the entire surface of the lithium-manganese composite oxide; however, one embodiment of the present invention is not limited thereto.", "For example, when the primary particle 111 is cleaved to be the particles 111a and 111b and the particles 111a and 111b slide along the cleavage plane, graphene may be formed so as to collectively cover the particles 111a and 111b.", "In that case, graphene 121a is formed so as to cover exposed portions of the cleavage planes of the particles 111a and 111b.", "Furthermore, graphene 130a is provided on at least part of a cleavage plane of a particle 113a.", "Note that in the case where cleavage is not caused like a primary particle 112, graphene 122 may be formed so as to cover the whole of the primary particle 112.Note that oxygen in graphene oxide is not necessarily entirely deintercalated and may remain partly in the graphene.", "In the case where graphene contains oxygen, the proportion of oxygen in the graphene measured by XPS is higher than or equal to 2 atomic % and lower than or equal to 20 atomic %, preferably higher than or equal to 3 atomic % and lower than or equal to 15 atomic %.", "Through the above steps, an active material in which graphene is provided on at least part of a cleavage plane of the lithium-manganese composite oxide can be formed.", "Note that although some primary particles do not have a cleavage plane, graphene is preferably provided on surfaces of such particles.", "Graphene has excellent electrical characteristics of high conductivity and excellent physical properties of high flexibility and high mechanical strength.", "For this reason, in a battery including an electrode containing the active material, the lithium-manganese composite oxide can be prevented from being further cleaved and cracked because of the volume change even when the lithium-manganese composite oxide repeats expansion and contraction accompanied by repeated charge and discharge of the battery.", "The substance obtained through the reduction step of graphene oxide is dried using the spray, dryer device, whereby the lithium-manganese composite oxides covered with graphene can become a secondary particles.", "As a result, the particle diameter of the active material can be greater than or equal to 1 μm and less than or equal to 50 μm.", "In the active material, which includes the secondary particle obtained through the reduction step of graphene oxide and the drying step, lithium-manganese composite oxides are bound with graphene.", "Thus, the conductivity of the active material can be high as compared with the case where lithium-manganese composite oxides are directly bound to be a secondary particle and a surface thereof is covered with graphene.", "When the active material is used for an electrode, the resistance of the electrode can be reduced.", "Furthermore, by making lithium-manganese composite oxides be a secondary particle, the surface area of the active material can be reduced, the compounding amount of a binder can be reduced, and the capacity per weight or per volume of the electrode can be increased.", "In addition, pressure applied to the lithium-manganese composite oxides, which is due to pressure applied to the electrode in a formation process of the electrode, can be alleviated owing to the mechanical strength of graphene.", "This can prevent the lithium-manganese composite oxides from being further cleaved and cracked.", "Moreover, even when a great stress is caused at the time of winding an electrode of a wound battery or even when an outward stress from an axis of winding is applied to the electrode all the time in the case where a wound body of the electrode is stored in a housing, the lithium-manganese composite oxides can be prevented from being further cleaved and cracked.", "When the active material in which at least part of the cleavage plane is covered with graphene is used for an electrode as described above, a decrease in the voltage and discharge capacity of a battery can be prevented.", "Accordingly, the charge-discharge cycle characteristics of the battery can be improved.", "Furthermore, when the active material of one embodiment of the present invention is used for an electrode, a high-capacity power storage device having a discharge capacity per active material weight of higher than or equal to 300 mAh/g can be manufactured.", "This embodiment can be implemented in combination with any of the other embodiments as appropriate.", "Embodiment 2 In this embodiment, an electrode of one embodiment of the present invention and a method for forming the electrode will be described.", "<Structure of Electrode> FIG.", "3A is an overhead view of an electrode 100, and FIG.", "3B is a cross-sectional view of a portion surrounded by a broken line in FIG.", "3A.", "The electrode 100 has a structure in which an active material layer 102 is provided over a current collector 101.Although the active material layers 102 are provided such that the current collector 101 is sandwiched therebetween in FIG.", "3A, the active material layer 102 may be formed over only one surface of the current collector 101.There is no particular limitation on the current collector 101 as long as it has high conductivity without causing a significant chemical change in a power storage device.", "For example, the current collector 101 can be formed using a metal such as stainless steel, gold, platinum, zinc, iron, nickel, copper, aluminum, titanium, tantalum, or manganese, an alloy thereof; sintered carbon, or the like.", "Alternatively, copper or stainless steel that is coated with carbon, nickel, titanium, or the like can be used to form the current collector 101.Alternatively, the current collector 101 can be formed using an aluminum alloy to which an element that improves heat resistance, such as silicon, neodymium, scandium, or molybdenum, is added.", "Still alternatively, a metal element that forms silicide by reacting with silicon can be used.", "Examples of the metal element that forms silicide by reacting with silicon include zirconium, titanium, hafnium, vanadium, niobium, tantalum, chromium, molybdenum, tungsten, cobalt, nickel, and the like.", "The current collector 101 can have any of various shapes including a foil-like shape, a plate-like shape (sheet-like shape), a net-like shape, a cylindrical shape, a coil shape, a punching-metal shape, an expanded-metal shape, a porous shape, and a shape of non-woven fabric as appropriate.", "The current collector 101 may be formed to have micro irregularities on the surface thereof in order to enhance adhesion to the active material layer, for example.", "The current collector 101 preferably has a thickness of 5 μm to 30 μm inclusive.", "The positive electrode active material layer 102 includes the active material.", "An active material refers only to a material that relates to insertion and extraction of ions that carriers.", "In this specification and the like, a material that is actually an “active material” and the material including a conductive additive, a binder, and the like are collectively referred to as an active material layer.", "In the case where the active material is used as a negative electrode active material, for example, a carbon-based material, an alloy-based material, or the like can be used.", "Examples of the carbon-based material include graphite, graphitizing carbon (soft carbon), non-graphitizing carbon (hard carbon), a carbon nanotube, graphene, and carbon black.", "Examples of graphite include artificial graphite such as meso-carbon microbeads (MCMB), coke-based artificial graphite, and pitch-based artificial graphite and natural graphite such as spherical natural graphite.", "Graphite has a low potential substantially equal to that of a lithium metal (higher than or equal to 0.1 V and lower than or equal to 0.3 V vs. Li/Li+) when lithium ions are intercalated into the graphite (while a lithium-graphite intercalation compound is formed).", "For this reason, a lithium-ion secondary battery can have a high operating voltage.", "In addition, graphite is preferred because of its advantages such as relatively high capacity per unit volume, small volume expansion, low cost, and higher level of safety than that of a lithium metal.", "For the negative electrode active material, a material which enables charge-discharge reactions by an alloying reaction and a dealloying reaction with lithium can be used.", "A material containing at least one of Ga, Si, Al, Si, Ge, Sn, Pb, Sb, Bi, Ag, Au, Zn, Cd, In, and the like can be used, for example.", "Such elements have higher capacity than carbon.", "In particular, silicon has a significantly high theoretical capacity of 4200 mAh/g.", "Examples of an alloy-based material using such elements include Mg2Si, Mg2Ge, Mg2Sn, SnS2, V2Sn3, FeSn2, CoSn2, Ni3Sn2, Cu6Sn5, Ag3Sn, Ag3Sb, Ni2MnSb, CeSb3, LaSn3, La3Co2Sn7, CoSb3, InSb, SbSn, and the like.", "Alternatively, for the negative electrode active materials, an oxide such as SiO, SnO, SnO2, titanium dioxide (TiO2), lithium titanium oxide (Li4Ti5O12), lithium-graphite intercalation compound (LixC6), niobium pentoxide (Nb2O5), tungsten oxide (WO2), or molybdenum oxide (MoO2) can be used.", "Still alternatively, for the negative electrode active materials, Li3-xMxN (M=Co, Ni, or Cu) with a Li3N structure, which is a nitride containing lithium and a transition metal, can be used.", "For example, Li2.6Co0.4N3 is preferable because of high charge and discharge capacity (900 mAh/g and 1890 mAh/cm3).", "A nitride containing lithium and a transition metal is preferably used, in which case lithium ions are contained in the negative electrode active materials and thus the negative electrode active materials can be used in combination with a material for a positive electrode active material which does not contain lithium ions, such as V2O5 or Cr3O8.In the case of using a material containing lithium ions as a positive electrode active material, the nitride containing lithium and a transition metal can be used for the negative electrode active material by extracting the lithium ions contained in the positive electrode active material in advance.", "Alternatively, a material which causes a conversion reaction can be used for the negative electrode active materials; for example, a transition metal oxide with which an alloying reaction with lithium is not caused, such as cobalt oxide (CoO), nickel oxide (NiO), and iron oxide (FeO), may be used.", "Other examples of the material which causes a conversion reaction include oxides such as Fe2O3, CuO, Cu2O, RuO2, and Cr2O3, sulfides such as CoS0.89, NiS, and CuS, nitrides such as Zn3N2, Cu3N, and Ge3N4, phosphides such as NiP2, FeP2, and CoP3, and fluorides such as FeF3 and BiF3.Note that any of the fluorides can be used as a positive electrode active material because of its high potential.", "In the case where the active material is a positive electrode active material, a material into and from which lithium ions can be intercalated and deintercalated can be used; for example, a material having an olivine crystal structure, a layered rock-salt crystal structure, a spinel crystal structure, or a NASICON crystal structure, or the like can be used, Although the case of using the active material described in Embodiment 1 as the positive electrode active material is described in this embodiment, a different active material may be used.", "Examples of active materials other than the active material described in Embodiment 1 include compounds such as LiFeO2, LiCoO2, LiNiO2, LiMn2O4, V2O5, Cr2O5, and MnO2.Alternatively, lithium-containing complex phosphate, LiMPO4 (general formula, where M is one or more of Fe(II), Mn(II), Co(II), and Ni(II)), can be used.", "Typical examples of LiMPO4 are lithium metal phosphate compounds such as LiFePO4, LiNiPO4, LiCoPO4, LiMnPO4, LiFenNibPO4, LiFeaCobPO4, LiFeaMnbPO4, LiNiaCobPO4, LiNiaMnbPO4 (a+b≤1, 0<a<1, and 0<b<1), LiFecNidCoePO4, LiFecNidMnePO4, LiNicCodMnePO4 (c+d+e≤1, 0<c<1, 0<d<1, and, 0<e<1), and LiFefNigCohMniPO4 (f+g+h+i≤1, 0<f<1, 0<g<1, 0<h<1, and 0<i<1).", "Alternatively, lithium-containing complex silicate such as Li(2-j)MSiO4 (general formula, where M is one or more of Fe(II), Mn(II), Co(II), and Ni(II), and 0≤j≤2) may be used.", "Typical examples of Li(2-j)MSiO4 are lithium silicate compounds such as Li(2-j)FeSiO4, Li(2-j)NiSiO4, Li(2-j)CoSiO4, Li(2-j)MnSiO4, Li(2-j)FekNilSiO4, Li(2-j)FekColSiO4, Li(2-j)FekMnlSiO4, Li(2-j)NikColSiO4, Li(2-j)NikMnlSiO4 (k+l≤1, 0<k<1, and 0<l<1), Li(2-j)FemNinCoqSiO4, Li(2-j)FemNinMnqSiO4, Li(2-j)NimConMnqSiO4 (m+n+q≤1, 0<m<1, 0<n<1, and 0<q<1), and Li(2-j)FerNisCotMnuSiO4 (r+s+t+u≤1, 0<r<1, 0<s<1, 0<t<1, and 0<u<1).", "Still alternatively, a NASICON compound expressed by AxM2(XO4)3 (general formula, where A=Li, Na, or Mg, M=Fe, Mn, Ti, V, Nb, or Al, X═S, P, Mo, W, As, or Si) can be used for the active material.", "Examples of the NASICON compound are Fe2(MnO4)3, Fe2(SO4)3, and Li3Fe2(PO4)3.Further alternatively, a compound expressed by Li2MPO4F, Li2MP2O7, or Li5MO4 (general formula, where M=Fe or Mn), a perovskite fluoride such as NaF3 and FeF3, a metal chalcogenide (a sulfide, a selenide, or a telluride) such as TiS2 and MoS2, a material with an inverse spinel structure such as LiMVO4, a vanadium oxide (V2O5, V6O13, LiV3O8, or the like), a manganese oxide, an organic sulfur compound, or the like can be used as the positive electrode active material.", "In the case where carrier ions are alkali metal ions other than lithium ions, or alkaline-earth metal ions, a compound containing carriers such as an alkali metal (e.g., sodium or potassium) or an alkaline-earth metal (e.g., calcium, strontium, barium, beryllium, or magnesium) instead of lithium of the lithium compound, the lithium-containing complex phosphate, or the lithium-containing complex silicate may be used as the positive electrode active material.", "The average particle size of the positive electrode active material is preferably, for example, greater than or equal to 5 nm and less than or equal to 50 μm.", "The active material layer 102 may include a conductive additive.", "Examples of the conductive additive include natural graphite, artificial graphite such as meso-carbon microbeads, and carbon fiber.", "Examples of carbon fiber include mesophase pitch-based carbon fiber, isotropic pitch-based carbon fiber, carbon nanofiber, and carbon nanotube.", "Carbon nanotube can be formed by, for example, a vapor deposition method.", "Other examples of the conductive additive include carbon materials such as carbon black (acetylene black (AB)) and graphene.", "Alternatively, metal powder or metal fiber of copper, nickel, aluminum, silver, gold, or the like, a conductive ceramic material, or the like can be used.", "Flaky graphene has excellent electrical characteristics of high conductivity and excellent physical properties of high flexibility and high mechanical strength.", "For this reason, the use of graphene as the conductive additive can increase the points and the area where the active materials are in contact with each other.", "The active material layer 102 preferably includes a binder, more preferably a binder that contains water-soluble polymers.", "The active material layer 102 may include a plurality of kinds of binders.", "As the binder, a rubber material such as styrene-butadiene rubber (SBR), styrene-isoprene-styrene rubber, acrylonitrile-butadiene rubber, butadiene rubber, or ethylene-propylene-diene copolymer is preferably used.", "Any of these rubber materials is more preferably used in combination with water-soluble polymers.", "Since these rubber materials have rubber elasticity and easily expand and contract, it is possible to obtain a highly reliable electrode that is resistant to stress due to expansion and contraction of an active material by charge and discharge, bending of the electrode, or the like.", "On the other hand, the rubber materials have a hydrophobic group and thus are unlikely to be soluble in water in some cases.", "In such a case, particles are dispersed in water without being dissolved, so that increasing the viscosity of a composition containing a solvent used for the formation of the active material layer 102 (also referred to as an electrode binder composition) up to the viscosity suitable for application might be difficult.", "Water-soluble polymers having an excellent function of adjusting viscosity, such as a polysaccharide, can moderately increase the viscosity of the solution and can be uniformly dispersed together with a rubber material.", "Thus, a favorable electrode with high uniformity (e.g., an electrode with uniform electrode thickness or electrode resistance) can be obtained.", "As the binder, a material such as polystyrene, poly(methyl acrylate), poly(methyl methacrylate) (PMMA), sodium polyacrylate, polyvinyl alcohol (PVA), polyethylene oxide (PEO), polypropylene oxide, polyimide, polyvinyl chloride, polytetrafluoroethylene, polyethylene, polypropylene, isobutylene, polyethylene terephthalate, nylon, polyvinylidene fluoride (PVdF), or polyacrylonitrile (PAN) can be used.", "A single binder may be used or plural kinds of binders may be used in combination.", "<Formation Method of Electrode> Next, a method for forming the electrode 100 of one embodiment of the present invention will be described.", "First, an electrode binder composition is formed.", "The electrode binder composition can be formed in such a manner that the above-described active material to which a conductive additive, a binder, and the like are added as appropriate is mixed with a solvent, for example.", "The electrode binder composition may be slurry or a paste.", "As the solvent, for example, water or N-methyl-2-pyrrolidone (NMP) can be used.", "The case where the electrode 100 is a positive electrode of a storage battery will be described as an example.", "Described here is an example where the active material of one embodiment of the present invention is used as an active material, acetylene black is used as a conductive additive, PVdF is used as a binder, and NMP is used as a solvent.", "First, the active material of one embodiment of the present invention, acetylene black, and polyvinylidene fluoride are mixed.", "Then, NMP is added to the obtained mixture and mixed until predetermined viscosity is obtained; thus, the electrode binder composition can be formed.", "In this step, the mixing and the addition of the polar solvent may be repeated more than once.", "Through the above steps, the electrode binder composition in which the active material, the conductive additive, and the binder are uniformly dispersed can be obtained.", "Here, an undercoat may be formed over the current collector.", "Note that the undercoat is a coating layer provided to reduce contact resistance or to improve adhesion between the current collector and the active material layer.", "Examples of the undercoat include a carbon layer, a metal layer, a layer containing carbon and high molecules, and a layer containing metal and high molecules.", "Forming the undercoat over the current collector can reduce the contact resistance between the current collector and the active material layer formed later, and/or can increase adhesion between the active material layer and the current collector.", "In addition, the adhesion between the current collector and the active material layer can be increased.", "In the case of using graphene as the conductive additive, the undercoat is preferably not dissolved by a reducing solution in the process of reducing graphene oxide.", "As the undercoat, for example, an aqueous solution in which graphite, acetylene black, and the like are dispersed or the aqueous solution into which high molecules are mixed can be used.", "Examples of the undercoat include a mixture of graphite and sodium polyacrylate (PAA) and a mixture of AB and PVdF.", "The compounding ratio of black lead to PAA is preferably 95:5 to 50:50, and the compounding ratio of AB to PVdF is preferably 70:30 to 50:50.Note that if there is no problem with the adhesion between the current collector and the active material layer, the electrode strength, and the contact resistance, it is not necessary to apply the undercoat to the current collector.", "Next, slurry is provided on one or both surfaces of the dent collector by a coating method such as a doctor blade method.", "When a secondary particle of the lithium-manganese composite oxides is used as the active material as described in Embodiment 1, the slurry can be applied thick to the current collector.", "Furthermore, by making lithium-manganese composite oxides be a secondary particle, the surface area of the active material can be reduced, the compounding amount of a binder can be reduced, and the capacity per weight or per volume of the electrode can be increased.", "Next, the slurry formed over the current collector is dried by a method such as ventilation drying or reduced pressure (vacuum) drying to form the active material layer.", "The drying is preferably performed using a hot wind with temperatures of 50° C. to 180° C. Through this step, the polar solvent contained in the active material layer is evaporated.", "Note that there is no particular limitation on the atmosphere.", "The active material layer may be pressed by a compression method such as a roll press method or a flat plate press method to increase the density of the active material layer.", "When the pressing is performed while being heated at higher than or equal to 90° C. and lower than or equal to 180° C., preferably lower than or equal to 120° C., the binder (e.g., PVdF) contained in the undercoat or the active material layer is softened to such an extent that the characteristics of the electrode is not changed, further increasing the adhesion between the current collector and the active material layer.", "Then, the pressed active material layer is dried.", "The drying is preferably performed under a reduced pressure (in vacuum) or in a reduction atmosphere.", "This drying step may be performed at temperatures of 50° C. to 300° C. for 1 hour to 48 hours, for example.", "The drying allows sufficient evaporation or removal of the polar solvent and moisture in the active material layer.", "The current collector over which the active material layer is formed may be further pressed.", "Thus, the adhesion between the current collector and the active material layer can be increased.", "In addition, the density of the active material layer can be increased.", "When the pressing is performed while being heated at higher than or equal to 90° C. and lower than or equal to 180° C., preferably lower than or equal to 120° C., the binder (e.g., PVdF) contained in the undercoat or the active material layer is softened to such an extent that the characteristics of the electrode is not changed, further increasing the adhesion between the current collector and the active material layer.", "Lastly, the current collector and the active material layer are stamped to have a predetermined size, whereby the electrode is formed.", "With the use of the active material of one embodiment of the present invention, pressure applied to the lithium-manganese composite oxides, which is due to pressure applied to the electrode in a formation process of the electrode, can be alleviated owing to the mechanical strength of graphene.", "This can prevent the lithium-manganese composite oxides from being further cleaved and cracked.", "Moreover, even when a great stress is caused at the time of winding an electrode of a wound battery or even when an outward stress from an axis of winding is applied to the electrode all the time in the case where a wound body of the electrode is stored in a housing, the lithium-manganese composite oxides can be prevented from being further cleaved and cracked by the stress.", "When the active material in which at least part of the cleavage plane is covered with graphene is used for an electrode as described above, a decrease in the voltage and discharge capacity of a battery can be prevented.", "Accordingly, the charge-discharge cycle characteristics of the battery can be improved.", "Furthermore, with the use of the secondary particle of the lithium-manganese composite oxides as the active material in the electrode, the active material layer over the current collector can be made thick.", "In addition, when the lithium-manganese composite oxides are made to be a secondary particle, the proportion of a binder used for forming the active material layer can be small as compared with the case where the lithium-manganese composite oxides are not made to be a secondary particle.", "As a result, the supported amount of the active material contained in the active material layer can be increased and the capacity of the electrode can be increased.", "Furthermore, by making lithium-manganese composite oxides be a secondary particle, the surface area of the active material can be reduced, the compounding amount of a binder can be reduced, and the capacity per weight or per volume of the electrode can be increased.", "Moreover, when the active material of one embodiment of the present invention is used for an electrode, a high-capacity power storage device having a discharge capacity per active material weight of higher than or equal to 300 mAh/g can be manufactured.", "This embodiment can be implemented in combination with any of the other embodiments as appropriate.", "Embodiment 3 Described in this embodiment will be an example of a power storage device using the electrode of one embodiment of the present invention.", "Note that the power storage device in this specification and the like indicates all elements and devices that have the function of storing electric power.", "For example, a storage battery such as a lithium-ion secondary battery, a lithium-ion capacitor, and an electric double layer capacitor are included in the category of the power storage device.", "<Thin Storage Battery> FIG.", "4 illustrates a thin storage battery as an example of a storage device.", "When a flexible thin storage battery is used in an electronic device at least part of which is flexible, the storage battery can be bent as the electronic device is bent.", "FIG.", "4 is an external view of a thin storage battery 500.FIG.", "5A is a cross-sectional view along dashed-dotted line A1-A2 in FIG.", "4, and FIG.", "5B is a cross-sectional view along dashed-dotted line B1-B2 in FIG.", "4.The thin storage battery 500 includes a positive electrode 503 including a positive electrode current collector 501 and a positive electrode active material layer 502, a negative electrode 506 including a negative electrode current collector 504 and a negative electrode active material layer 505, a separator 507, an electrolytic solution 508, and an exterior body 509.The separator 507 is provided between the positive electrode 503 and the negative electrode 506 in the exterior body 509.The electrolytic solution 508 is included in the exterior body 509.As at least one of the positive electrode 503 and the negative electrode 506, the electrode of one embodiment of the present invention is used.", "The electrode of one embodiment of the present invention may be used as both the positive electrode 503 and the negative electrode 506.Here, a structure of the positive electrode 503 will be described.", "The electrode of one embodiment of the present invention is preferably used as the positive electrode 503.Here, an example of using the electrode 100 described in Embodiment 2 as the positive electrode 503 will be described.", "As a solvent of the electrolytic solution 508, an aprotic organic solvent is preferably used.", "For example, one of ethylene carbonate (EC), propylene carbonate (PC), butylene carbonate, chloroethylene carbonate, vinylene carbonate, γ-butyrolactone, γ-valerolactone, dimethyl carbonate (DMC), diethyl carbonate (DEC), ethyl methyl carbonate (EMC), methyl formate, methyl acetate, methyl butyrate, 1,3-dioxane, 1,4-dioxane, dimethoxyethane (DME), dimethyl sulfoxide, diethyl ether, methyl diglyme, acetonitrile, benzonitrile, tetrahydrofuran, sulfolane, and sulfone can be used, or two or more of these solvents can be used in an appropriate combination in an appropriate ratio.", "When a high-molecular material that undergoes gelation is used as a solvent electrolytic, solution, safety against liquid leakage and the like is improved.", "Furthermore, a secondary battery can be thinner and more lightweight.", "Typical examples of the high-molecular material that undergoes gelation include a silicone gel, an acrylic gel, an acrylonitrile gel, a polyethylene oxide-based gel, a polypropylene oxide-based gel, a fluorine-based polymer gel, and the like.", "Alternatively; the use of one or more kinds of ionic liquids (room temperature molten salts) which have features of non-flammability and non-volatility as a solvent of the electrolytic solution can prevent a power storage device from exploding or catching fire even when a power storage device internally shorts out or the internal temperature increases owing to overcharging or the like.", "An ionic liquid contains a cation and an anion.", "The ionic liquid of one embodiment of the present invention contains an organic cation and an anion.", "Examples of the organic cation used for the electrolytic solution include aliphatic onium cations such as a quaternary ammonium cation, a tertiary sulfonium cation, and a quaternary phosphonium cation, and aromatic cations such as an imidazolium cation and a pyridinium cation.", "Examples of the anion used for the electrolytic solution include a monovalent amide-based anion, a monovalent methide-based anion, a fluorosulfonate anion, a perfluoroalkylsulfonate anion, tetrafluoroborate, perfluoroalkylborate, hexafluorophosphate, and perfluoroalkylphosphate.", "In the case of using lithium ions as carriers, as an electrolyte dissolved in the above-described solvent, one of lithium salts such as LiPF6, LiClO4, LiAsF6, LiBF4, LiAlCl4, LiSCN, LiBr, LiI, Li2SO4, Li2B10Cl10, Li2B12Cl12, LiCF3SO3, LiC4F9SO3, LiC(CF3SO2)3, LiC(C2F5SO2)3, LiN(CF3SO2)2, LiN(C4F9SO2)(CF3SO2), and LiN(C2F5SO2)2 can be used, or two or more of these lithium salts can be used in an appropriate combination in an appropriate ratio.", "The electrolytic solution used for a power storage device is preferably highly purified and contains a small amount of dust particles and elements other than the constituent elements of the electrolytic solution (hereinafter, also simply referred to as impurities).", "Specifically, the weight ratio of impurities to the electrolytic solution is less than or equal to 1 wt %, preferably less than or equal to 0.1 wt %, and more preferably less than or equal to 0.01 wt %.", "Furthermore, an additive agent such as vinylene carbonate, propane sultone (PS), tert-butylbenzene (TBB), fluoroethylene carbonate (FEC), or LiBOB may be added to the electrolytic solution.", "The concentration of such an additive agent in the whole solvent is, for example, higher than or equal to 0.1 wt % and lower than or equal to 5 wt %.", "Alternatively, a gelled electrolyte obtained in such a manner that a polymer is swelled with an electrolytic solution may be used.", "Examples of the gelled electrolyte (polymer-gel electrolyte) include a host polymer that is used as a support and contains the electrolytic solution described above.", "Examples of host polymers include a polymer having a polyalkylene oxide structure, such as polyethylene oxide (PEO); PVdF; polyacrylonitrile; and a copolymer containing any of them.", "For example, PVdF-HFP, which is a copolymer of PVdF and hexafluoropropylene (HFP) can be used.", "The formed polymer may be porous.", "Instead of the electrolytic solution, a solid electrolyte including an inorganic material such as a sulfide-based inorganic material or an oxide-based inorganic material, or a solid electrolyte including a macromolecular material such as a polyethylene-oxide-based (PEO-based) macromolecular material may alternatively be used.", "When the solid electrolyte is used, a separator and a spacer are not necessary.", "Furthermore, the battery can be entirely solidified; therefore, there is no possibility of liquid leakage and thus the safety of the battery is dramatically increased.", "As the separator 507, paper; nonwoven fabric; glass fiber; ceramics; synthetic fiber containing nylon (polyimide), vinylon (polyvinyl alcohol-based fiber), polyester, acrylic, polyolefin, or polyurethane; or the like can be used.", "The separator 507 is preferably formed to have a bag-like shape to surround one of the positive electrode 503 and the negative electrode 506.For example, as illustrated, in FIG.", "6A, the separator 507 is folded in two so that the positive electrode 503 is sandwiched, and sealed with a sealing portion 514 in a region outside the region overlapping with the positive electrode 503; thus, the positive electrode 503 can be reliably supported inside the separator 507.Then, as illustrated in FIG.", "6B, the positive electrodes 503 surrounded by the separators 507 and the negative electrodes 506 are alternately stacked and provided in the exterior body 509, whereby the thin storage battery 500 can be formed.", "Next, aging after fabrication of a storage battery will be described.", "Aging is preferably performed after fabrication of a storage battery.", "The aging can be performed under the following conditions, for example.", "Charge is performed at a rate of 0.001 C or more and 0.2 C or less at a temperature higher than or equal to room temperature and lower than or equal to 50° C. In the case where an electrolytic solution is decomposed and a gas is generated and accumulated in the cell, the electrolytic solution cannot be in contact with a surface of the electrode in some regions.", "That is to say, an effectual reaction area of the electrode is reduced and effectual current density is increased.", "When the current density is extremely high, a voltage drop occurs depending on the resistance of the electrode, lithium is intercalated into graphite, and lithium is deposited on the surface of graphite.", "The lithium deposition might reduce capacity.", "For example, if a coating film or the like is grown on the surface after lithium deposition, lithium deposited on the surface cannot be dissolved again.", "This lithium cannot contribute to capacity.", "In addition, when deposited lithium is physically collapsed and conduction with the electrode is lost, the lithium also cannot contribute to capacity.", "Therefore, the gas is preferably released before the potential of the electrode reaches the potential of lithium because of a voltage drop.", "After the release of the gas, the charging state may be maintained at a temperature higher than room temperature, preferably higher than or equal to 30° C. and lower than or equal to 60° C., more preferably higher than or equal to 35° C. and lower than or equal to 50° C. for, for example, 1 hour to 100 hours.", "In the initial charge, an electrolytic solution decomposed on the surface forms a coating film on the surface of graphite.", "The formed coating film may thus be densified when the charging state is held at a temperature higher than room temperature after the release of the gas, for example.", "FIG.", "7A illustrates an example where a current collector is welded to a lead electrode, specifically, an example where positive electrode current collectors 501 are welded to a positive electrode lead electrode 510.The positive electrode current collectors 501 are welded to the positive electrode lead electrode 510 in a welding region 512 by ultrasonic welding or the like.", "The positive electrode current collector 501 includes a bent portion 513 as illustrated in FIG.", "7B, and it is therefore possible to relieve stress due to external force applied after fabrication of the storage battery 500.Thus, the storage battery 500 can have high reliability.", "In the thin storage battery 500 illustrated in FIG.", "4 and FIGS.", "5A and 5B, the positive electrode current collectors 501 and the negative electrode current collectors 504 are welded to the positive electrode lead electrode 510 and a negative electrode lead electrode 511, respectively, by ultrasonic welding and part of the positive electrode lead electrode 510 and part of the negative electrode lead electrode 511 are exposed to the outside.", "The positive electrode current collector 501 and the negative electrode current collector 504 can double as terminals for electrical contact with the outside.", "In that case, the positive electrode current collector 501 and the negative electrode current collector 504 may be arranged so that part of the positive electrode current collector 501 and part of the negative electrode current collector 504 are exposed to the outside the exterior body 509 without using lead electrodes.", "Although the positive electrode lead electrode 510 and the negative electrode lead electrode 511 are provided on the same side in FIG.", "4, the positive electrode lead electrode 510 and the negative electrode lead electrode 511 may be provided on different sides as illustrated in FIG.", "8.The lead electrodes of a storage battery of one embodiment of the present invention can be freely positioned as described above; therefore, the degree of freedom in design is high.", "Accordingly, a product including a storage battery of one embodiment of the present invention can have a high degree of freedom in design.", "Furthermore, a yield of products each including a storage battery of one embodiment of the present invention can be increased.", "As the exterior body 509 in the thin storage battery 500, for example, a film having a three-layer structure in which a highly flexible metal thin film of aluminum, stainless steel, copper, nickel, or the like is provided over a film formed of a material such as polyethylene, polypropylene, polycarbonate, ionomer, or polyamide, and an insulating synthetic resin film of a polyamide-based resin, a polyester-based resin, or the like is provided as the outer surface of the exterior body over the metal thin film can be used.", "The example in FIG.", "4 includes five positive electrode-negative electrode pairs (the positive and negative electrodes face each other).", "It is needless to say that the number of pairs of electrodes is not limited to five, and may be more than or less than five.", "In the case of using a large number of electrode layers, the storage battery can have high capacity in contrast, in the case of using a small number of electrode layers, the storage battery can have a small thickness and high flexibility.", "In the above structure, the exterior body 509 of the storage battery can change its form with a radius of greater than or equal to 10 mm, preferably greater than or equal to 30 mm.", "One or two films are used as the exterior body of the storage battery.", "In the case where the storage battery has a layered structure, the storage battery has a cross section sandwiched by two curved surfaces of the films when it is bent.", "Description is given of the radius of curvature of a surface with reference to FIGS.", "9A to 9C.", "In FIG.", "9A, on a plane 1701 along which a curved surface 1700 is cut, part of a curve 1702 of the curved surface 1700 is approximate to an arc of a circle, and the radius of the circle is referred to as a radius of curvature 1703 and the center of the circle is referred to as a center 1704 of curvature.", "FIG.", "9B is a top view of the curved surface 1700.FIG.", "9C is a cross-sectional view of the curved surface 1700 taken along the plane 1701.When a curved surface is cut by a plane, the radius of curvature of a curve in a cross section differs depending on the angle between the curved surface and the plane or on the cut position, and the smallest radius of curvature is defined as the radius of curvature of a surface in this specification and the like.", "In the case of bending a secondary battery in which electrodes, an electrolytic solution, and the like are sandwiched between two films as exterior bodies, a radius of curvature 1802 of a film 1801 close to a center of curvature 1800 of the secondary battery is smaller than a radius of curvature 1804 of a film 1803 far from the center of curvature 1800 (FIG.", "10A).", "When the secondary battery is curved and has an arc-shaped cross section, compressive stress is applied to a surface of the film on the side closer to the center of curvature 1800 and tensile stress is applied to a surface of the film on the side farther from the center of curvature 1800 (FIG.", "10B).", "However, by forming a pattern including convex portions or concave portions on surfaces of the exterior bodies, the influence of a strain can be reduced to be acceptable even when compressive stress and tensile stress are applied.", "For this reason, the secondary battery can change its form such that the exterior body on the side closer to the center of curvature has a curvature radius greater than or equal to 10 mm, preferably greater than or equal to 30 mm.", "Note that the cross-sectional shape of the secondary battery is not limited to a simple arc shape, and the cross section can be partly arc-shaped; for example, a shape illustrated in FIG.", "10C, a wavy shape illustrated in FIG.", "10D, or an S shape can be used.", "When the curved surface of the secondary battery has a shape with a plurality of centers of curvature, the secondary battery can change its form such that a curved surface with the smallest radius of curvature among radii of curvature with respect to the plurality of centers of curvature, which is a surface of the exterior body on the side closer to the center of curvature, has a curvature radius greater than or equal to 10 mm, preferably greater than or equal to 30 mm.", "<Coin-Type Storage Battery> Next, an example of a coin-type storage battery will be described as an example of a power storage device with reference to FIGS.", "11A and 11B.", "FIG.", "11A is an external view of a coin-type (single-layer flat type) storage battery, and FIG.", "11B is a cross-sectional view thereof.", "In a coin-type storage battery 300, a positive electrode can 301 doubling as a positive electrode terminal and a negative electrode can 302 doubling as a negative electrode terminal are insulated from each other and sealed by a gasket 303 made of polypropylene or the like.", "A positive electrode 304 includes a positive electrode current collector 305 and a positive electrode active material layer 306 provided in contact with the positive electrode current collector 305.The description of the positive electrode active material layer 502 can be referred to for the positive electrode active material layer 306.A negative electrode 307 includes a negative electrode current collector 308 and a negative electrode active material layer 309 provided in contact with the negative electrode current collector 308.The description of the negative electrode active material layer 505 can be referred to for the negative electrode active material layer 309.The description of the separator 507 can be referred to for the separator 310.The description of the electrolytic solution 508 can be referred to for the electrolytic solution.", "Note that only one surface of each of the positive electrode 304 and the negative electrode 307 used for the coin-type storage battery 300 is provided with an active material layer.", "For the positive electrode can 301 and the negative electrode can 302, a metal having a corrosion-resistant property to an electrolytic solution, such as nickel, aluminum, or titanium, an alloy of such a metal, or an alloy of such a metal and another metal (e.g., stainless steel or the like) can be used.", "Alternatively, the positive electrode can 301 and the negative electrode can 302 are preferably covered with nickel, aluminum, or the like in order to prevent corrosion due to the electrolytic solution.", "The positive electrode can 301 and the negative electrode can 302 are electrically connected to the positive electrode 304 and the negative electrode 307, respectively.", "The negative electrode 307, the positive electrode 304, and the separator 310 are immersed in the electrolytic solution.", "Then, as illustrated in FIG.", "11B, the positive electrode 304, the separator 310, the negative electrode 307, and the negative electrode can 302 are stacked in this order with the positive electrode can 301 positioned at the bottom, and the positive electrode can 301 and the negative electrode can 302 are subjected to pressure bonding with the gasket 303 interposed therebetween.", "In such a manner, the coin-type storage battery 300 can be manufactured.", "<Cylindrical Storage Battery> Next, an example of a cylindrical storage battery will be described as an example of a power storage device with reference to FIGS.", "12A and 12B.", "As illustrated in FIG.", "12A, a cylindrical storage battery 600 includes a positive electrode cap (battery cap) 601 on the top surface and a battery can (outer can) 602 on the side surface and bottom surface.", "The positive electrode cap 601 and the battery can 602 are insulated from each other by a gasket (insulating gasket) 610.FIG.", "12B is a diagram schematically illustrating a cross section of the cylindrical storage battery.", "Inside the battery can 602 having a hollow cylindrical shape, a battery element in which a strip-like positive electrode 604 and a strip-like negative electrode 606 are wound with a stripe-like separator 605 interposed therebetween is provided.", "Although not illustrated, the battery element is wound around a center pin.", "One end of the battery can 602 is close and the other end thereof is open.", "For the battery can 602, a metal having a corrosion-resistant property to an electrolytic solution, such as nickel, aluminum, or titanium, an alloy of such a metal, or an alloy of such a metal and another metal (e.g., stainless steel or the like) can be used.", "Alternatively, the battery can 602 is preferably covered with nickel, aluminum, or the like in order to prevent corrosion due to the electrolytic solution.", "Inside the battery can 602, the battery element in which the positive electrode, the negative electrode, and the separator are wound is provided between a pair of insulating plates 608 and 609 which face each other.", "Furthermore, a nonaqueous electrolytic solution (not illustrated) is injected inside the battery can 602 provided with the battery element.", "As the nonaqueous electrolytic solution, a nonaqueous electrolytic solution that is similar to those of the coin-type storage battery can be used.", "The positive electrode 604 and the negative electrode 606 can be formed in a manner similar to that of the positive electrode and the negative electrode of the thin storage battery described above.", "Since the positive electrode and the negative electrode of the cylindrical storage battery are wound, active materials are preferably formed on both sides of the current collectors.", "A positive electrode terminal (positive electrode current collecting lead) 603 is connected to the positive electrode 604, and a negative electrode terminal (negative electrode current collecting lead) 607 is connected to the negative electrode 606.Both the positive electrode terminal 603 and the negative electrode terminal 607 can be formed using a metal material such as aluminum.", "The positive electrode terminal 603 and the negative electrode terminal 607 are resistance-welded to a safety valve mechanism 612 and the bottom of the battery can 602, respectively.", "The safety valve mechanism 612 is electrically connected to the positive electrode cap 601 through a positive temperature coefficient (PTC) element 611.The safety valve mechanism 612 cuts off electrical connection between the positive electrode cap 601 and the positive electrode 604 when the internal pressure of the battery exceeds a predetermined threshold value.", "The PTC element 611, which serves as a thermally sensitive resistor whose resistance increases as temperature rises, limits the amount of current by increasing the resistance, in order to prevent abnormal heat generation.", "Note that barium titanate (BaTiO3)-based semiconductor ceramic can be used for the PTC element.", "In the case where an electrode is wound as in the cylindrical storage battery illustrated in FIGS.", "12A and 12B, a great stress is caused at the time of winding the electrode.", "In addition, an outward stress from an axis of winding is applied to the electrode all the time in the case where a wound body of the electrode is stored in a housing.", "However, the active material can be prevented from being cleaved even when such a great stress is applied to the electrode.", "Note that in this embodiment, the coin-type storage battery, the cylindrical storage battery, and the thin storage battery are given as examples of the storage battery; however, any of storage batteries with a variety of shapes, such as a sealed storage battery and a square-type storage battery, can be used.", "Furthermore, a structure in which a plurality of positive electrodes, a plurality of negative electrodes, and a plurality of separators are stacked or wound may be employed.", "For example, FIGS.", "13A to 13C, FIGS.", "14A to 14C, FIGS.", "15A and 15B, FIGS.", "16A1, 16A2, 16B1, and 16B2, and FIGS.", "17A and 17B illustrate examples of other storage batteries.", "<Structural Example of Storage Battery> FIGS.", "13A to 13C and FIGS.", "14A to 14C illustrate structural examples of thin storage batteries.", "A wound body 993 illustrated in FIG.", "13A includes a negative electrode 994, a positive electrode 995, and a separator 996.The wound body 993 is obtained by winding a sheet of a stack in which the negative electrode 994 overlaps with the positive electrode 995 with the separator 996 therebetween.", "The wound body 993 is covered with a rectangular sealed container or the like; thus, a rectangular secondary battery is fabricated.", "Note that the number of stacks each including the negative electrode 994, the positive electrode 995, and the separator 996 is determined as appropriate depending on capacity and element volume which are required.", "The negative electrode 994 is connected to a negative electrode current collector (not illustrated) via one of a lead electrode 997 and a lead electrode 998.The positive electrode 995 is connected to a positive electrode current collector (not illustrated) via the other of the lead electrode 997 and the lead electrode 998.In a storage battery 980 illustrated in FIGS.", "13B and 13C, the wound body 993 is packed in a space formed by bonding a film 981 and a film 982 having a concave portion that serve as exterior bodies by thermocompression bonding or the like.", "The wound body 993 includes the lead electrode 997 and the lead electrode 998, and is soaked in an electrolytic solution inside a space surrounded by the film 981 and the film 982 having a concave portion.", "For the film 981 and the film 982 having a concave portion, a metal material such as aluminum or a resin material can be used, for example.", "With the use of a resin material for the film 981 and the film 982 having a concave portion, the film 981 and the film 982 having a concave portion can be changed in their forms when external force is applied; thus, a flexible storage battery can be fabricated.", "Although FIGS.", "13B and 13C illustrate an example where a space is formed by two films, the wound body 993 may be placed in a space formed by bending one film.", "Furthermore, in manufacturing a flexible power storage device, a resin material or the like can be used for an exterior body and a sealed container of the power storage device.", "Note that in the case where a resin material is used for the exterior body and the sealed container, a conductive material used for a portion connected to the outside.", "For example, FIGS.", "14B and 14C illustrate another example of a flexible thin storage battery.", "The wound body 993 illustrated in FIG.", "14A is the same as that illustrated in FIG.", "13A, and the detailed description thereof is omitted.", "In the storage battery 990 illustrated in FIGS.", "14B and 14C, the wound body 993 is packed in an exterior body 991.The wound body 993 includes the lead electrode 997 and the lead electrode 998, and is soaked in an electrolytic solution inside a space surrounded by the exterior body 991 and an exterior body 992.For example, a metal material such as aluminum or a resin material can be used for the exterior bodies 991 and 992.With the use of a resin material for the exterior bodies 991 and 992, the exterior bodies 991 and 992 can be changed in their forms when external force is applied; thus, a flexible thin storage battery can be fabricated.", "When the electrode containing the active material of one embodiment of the present invention is used in the flexible thin storage battery, the active material can be prevented from being cleaved even if a stress caused by repeated bending of the thin storage battery is applied to the electrode.", "When the active material in which at least part of the cleavage plane is covered with graphene is used for an electrode as described above, a decrease in the voltage and discharge capacity of a battery can be prevented.", "Accordingly, the charge-discharge cycle characteristics of the battery can be improved.", "<Structural Example of Power Storage System> Structural examples of power storage systems will be described with reference to FIGS.", "15A and 15B, FIGS.", "16A1, 16A2, 16B1, and 16B2, and FIGS.", "17A and 17B.", "Here, a power storage system refers to, for example, a device including a power storage device.", "FIGS.", "15A and 15B are external views of a power storage system.", "The power storage system includes a circuit board 900 and a storage battery 913.A label 910 is attached to the storage battery 913.As shown in FIG.", "15B, the power storage system further includes a terminal 951, a terminal 952, an antenna 914, and an antenna 915.The circuit board 900 includes terminals 911 and a circuit 912.The terminals 911 are connected to the terminals 951 and 952, the antennas 914 and 915, and the circuit 912.Note that a plurality of terminals 911 serving as a control signal input terminal, a power supply terminal, and the like may be provided.", "The circuit 912 may be provided on the rear surface of the circuit board 900.The shape of each of the antennas 914 and 915 is not limited to a coil shape and may be a linear shape or a plate shape.", "Further, a planar antenna, an aperture antenna, a traveling-wave antenna, an EH antenna, a magnetic-field antenna, or a dielectric antenna may be used.", "Alternatively, the antenna 914 or the antenna 915 may be a flat-plate conductor.", "The flat-plate conductor can serve as one of conductors for electric field coupling.", "That is, the antenna 914 or the antenna 915 can serve as one of two conductors of a capacitor.", "Thus, electric power can be transmitted and received not only by an electromagnetic field or a magnetic field but also by an electric field.", "The line width of the antenna 914 is preferably larger than that of the antenna 915.This makes it possible to increase the amount of electric power received by the antenna 914.The power storage system includes a layer 916 between the storage battery 913 and the antennas 914 and 915.The layer 916 may have a function of blocking an electromagnetic field by the storage battery 913.As the layer 916, for example, a magnetic body can be used.", "The layer 916 may serve as a shielding layer.", "Note that the structure of the power storage system is not limited to that illustrated in FIGS.", "15A and 15B.", "For example, as shown in FIGS.", "16A1 and 16A2, two opposite surfaces of the storage battery 913 in FIGS.", "15A and 15B may be provided with respective antennas.", "FIG.", "16A1 is an external view showing one side of the opposite surfaces, and FIG.", "16A2 is an external view showing the other side of the opposite surfaces.", "For portions similar to those in FIGS.", "15A and 15B, the description of the power storage system illustrated in FIGS.", "15A and 15B can be referred to as appropriate.", "As illustrated in FIG.", "16A1, the antenna 914 is provided on one of the opposite surfaces of the storage battery 913 with the layer 916 interposed therebetween, and as illustrated in FIG.", "16A2, the antenna 915 is provided on the other of the opposite surfaces of the storage battery 913 with a layer 917 interposed therebetween.", "The layer 917 may have a function of preventing an adverse effect on an electromagnetic field by the storage battery 913.As the layer 917, for example, a magnetic body can be used.", "The layer 917 may serve as a shielding layer.", "With the above structure, both of the antennas 914 and 915 can be increased in size.", "Alternatively, as illustrated in FIGS.", "16B1 and 16B2, two opposite surfaces of the storage battery 913 in FIGS.", "15A and 15B may be provided with different types of antennas.", "FIG.", "16B1 is an external view showing one side of the opposite surfaces, and FIG.", "16B2 is an external view showing the other side of the opposite surfaces.", "For portions similar to those in FIGS.", "15A and 15B, the description of the power storage system illustrated in FIGS.", "15A and 15B can be referred to as appropriate.", "As illustrated in FIG.", "16B1, the antennas 914 and 915 are provided on one of the opposite surfaces of the storage battery 913 with the layer 916 provided between the storage battery 913 and the antennas 914 and 915, and as illustrated in FIG.", "16B2, an antenna 918 is provided on the other of the opposite surfaces of the storage battery 913 with the layer 917 provided therebetween.", "The antenna 918 has a function of communicating data with an external device, for example.", "An antenna with a shape that can be applied to the antennas 914 and 915, for example, can be used as the antenna 918.As a system for communication using the antenna 918 between the power storage system and another device, a response method that can be used between the power storage system and another device, such as NFC, can be employed.", "Alternatively, as illustrated in FIG.", "17A, the storage battery 913 in FIGS.", "15A and 15B may be provided with a display device 920.The display device 920 is electrically connected to the terminal 911 via a terminal 919.It is possible that the label 910 is not provided in a portion where the display device 920 is provided.", "For portions similar to those in FIGS.", "15A and 15B, the description of the power storage system illustrated in FIGS.", "15A and 15B can be referred to as appropriate.", "The display device 920 can display, for example, an image showing whether charge is being carried out, an image showing the amount of stored power, or the like.", "As the display device 920, electronic paper, a liquid crystal display device, an electroluminescent (EL) display device, or the like can be used.", "For example, the use of electronic paper can reduce power consumption of the display device 920.Alternatively, as illustrated in FIG.", "17B, the storage battery 913 illustrated in FIGS.", "15A and 15B may be provided with a sensor 921.The sensor 921 is electrically connected to the terminal 911 via a terminal 922.For portions similar to those in FIGS.", "15A and 15B, the description of the power storage system illustrated in FIGS.", "15A and 15B can be referred to as appropriate.", "As the sensor 921, a sensor that has a function of measuring, for example, force, displacement, position, speed, acceleration, angular velocity, rotational frequency, distance, light, liquid, magnetism, temperature, chemical substance, sound, time, hardness, electric field, electric current, voltage, electric power, radiation, flow rate, humidity, gradient, oscillation, odor, or infrared rays can be used.", "With the sensor 921, for example, data on an environment (e.g., temperature) where the power storage system is placed can be determined and stored in a memory inside the circuit 912.The electrode of one embodiment of the present invention is used in the storage battery and the power storage system that are described in this embodiment.", "The capacity of the storage battery and the power storage system can thus be high.", "Furthermore, energy density can be high.", "Moreover, reliability can be high, and life can be long.", "This embodiment can be implemented in appropriate combination with any of the other embodiments.", "Embodiment 4 In this embodiment, an example of an electronic device including a flexible power storage device will be described.", "FIGS.", "18A to 18B illustrate examples of electronic devices including the flexible power storage device described in Embodiment 3.Examples of electronic devices each including the flexible power storage device include television devices (also referred to as televisions or television receivers), monitors of computers or the like, cameras such as digital cameras and digital video cameras, digital photo frames, mobile phones (also referred to as mobile phones or mobile phone devices), portable game machines, portable information terminals, audio reproducing devices, and large game machines such as pachinko machines.", "In addition, the flexible power storage device can be incorporated along a curved inside/outside wall surface of a house or a building or a curved interior/exterior surface of a car.", "FIG.", "18A illustrates an example of a mobile phone.", "A mobile phone 7400 is provided with a display portion 7402 incorporated in a housing 7401, an operation button 7403, an external connection port 7404, a speaker 7405, a microphone 7406, and the like.", "Note that the mobile phone 7400 includes a power storage device 7407.FIG.", "18B illustrates the mobile phone 7400 that is bent.", "When the whole mobile phone 7400 is bent by the external force, the power storage device 7407 included in the mobile phone 7400 is also bent.", "FIG.", "18C illustrates the bent power storage device 7407.The power storage device 7407 is a thin storage battery.", "The power storage device 7407 is fixed in a state of being bent.", "Note that the power storage device 7407 includes a lead electrode 7408 electrically connected to a current collector 7409.The current collector 7409 is, for example, copper foil, and partly alloyed with gallium; thus, adhesion between the current collector 7409 and an active material layer in contact with the current collector 7409 is improved and the power storage device 7407 can have high reliability even in a state of being bent.", "FIG.", "18D illustrates an example of a bangle display device.", "A portable display device 7100 includes a housing 7101, a display portion 7102, an operation button 7103, and a power storage device 7104.FIG.", "18E illustrates the bent power storage device 7104.When the display device is worn on a user's arm while the power storage device 7104 is bent, the housing changes its form and the curvature of a part or the whole of the power storage device 7104 is changed.", "Note that the radius of curvature of a curve at a point refers to the radius of the circular arc that best approximates the curve at that point.", "The reciprocal of the radius of curvature is curvature.", "Specifically, a part or the whole of the housing or the main surface of the power storage device 7104 is changed in the range of radius of curvature from 40 mm to 150 mm.", "When the radius of curvature at the main surface of the power storage device 7104 is greater than or equal to 40 mm and less than or equal to 150 mm, the reliability can be kept high.", "FIG.", "18F illustrates an example of a watch-type portable information terminal.", "A portable information terminal 7200 includes a housing 7201, a display portion 7202, a band 7203, a buckle 7204, an operation button 7205, an input output terminal 7206, and the like.", "The portable information terminal 7200 is capable of executing a variety of applications such as mobile phone calls, e-mailing, viewing and editing texts, music reproduction, Internet communication, and a computer game.", "The display surface of the display portion 7202 is curved, and images can be displayed on the curved display surface.", "In addition, the display portion 7202 includes a touch sensor, and operation can be performed by touching the screen with a finger, a stylus, or the like.", "For example, by touching an icon 7207 displayed on the display portion 7202, application can be started.", "With the operation button 7205, a variety of functions such as time setting, on/off of the power, on/off of wireless communication, setting and cancellation of a manner mode, and setting and cancellation of a power saving mode can be performed.", "For example, the functions of the operation button 7205 can be set freely by setting the operating system incorporated in the portable information terminal 7200.The portable information terminal 7200 can employ near field communication that is a communication method based on an existing communication standard.", "In that case, for example, mutual communication between the portable information terminal 7200 and a headset capable of wireless communication can be performed, and thus hands-free calling is possible.", "Moreover, the portable information terminal 7200 includes the input output terminal 7206, and data can be directly transmitted to and received from another information terminal via a connector.", "In addition, charging via the input output terminal 7206 is possible.", "Note that the charging operation may be performed by wireless power feeding without using the input output terminal 7206.The display portion 7202 of the portable information terminal 7200 is provided with a power storage device including the electrode member of one embodiment of the present invention.", "For example, the power storage device 7104 illustrated in FIG.", "18E that is in the state of being curved can be provided in the housing 7201.Alternatively, the power storage device 7104 illustrated in FIG.", "18E can be provided in the band 7203 such that it can be curved.", "FIG.", "188 illustrates an example of an armband display device.", "A display device 7300 includes a display portion 7304 and the power storage device of one embodiment of the present invention.", "The display device 7300 can include a touch sensor in the display portion 7304 and can serve as a portable information terminal.", "The display surface of the display portion 7304 is bent, and images can be displayed on the bent display surface.", "A display state of the display device 7300 can be changed by, for example, near field communication, which is a communication method based on an existing communication standard.", "The display device 7300 includes an input output terminal, and data can be directly transmitted to and received from another information terminal via a connector.", "In addition, charging via the input output terminal is possible.", "Note that the charging operation may be performed by wireless power feeding without using the input output terminal.", "This embodiment can be implemented in appropriate combination with any of the other embodiments.", "Embodiment 5 In this embodiment, examples of electronic devices that can include power storage devices will be described.", "FIGS.", "19A and 19B illustrate an example of a tablet terminal that can be folded in half A tablet terminal 9600 illustrated in FIGS.", "19A and 198 includes a housing 9630a, a housing 9630b, a movable portion 9640 connecting the housings 9630a and 9630b, a display portion 9631 including a display portion 9631a and a display portion 9631b, a display mode changing switch 9626, a power switch 9627, a power saving mode changing switch 9625, a fastener 9629, and an operation switch 9628.FIG.", "19A illustrates the tablet terminal 9600 that is opened, and FIG.", "19B illustrates the tablet terminal 9600 that is closed.", "The tablet terminal 9600 includes a power storage unit 9635 inside the housings 9630a and 9630b.", "The power storage unit 9635 is provided across the housings 9630a and 9630b, passing through the movable portion 9640.Part of the display portion 9631a can be a touch panel region 9632a, and data can be input by touching operation keys 9638 that are displayed.", "Note that FIG.", "19A shows, as an example, that half of the area of the display portion 9631a has only a display function and the other half of the area has a touch panel function.", "However, the structure of the display portion 9631a is not limited to this, and all the area of the display portion 9631a may have a touch panel function.", "For example, all the area of the display portion 9631a can display a keyboard and serve as a touch panel while the display portion 9631b can be used as a display screen.", "As in the display portion 9631a, part of the display portion 9631b can be a touch panel region 9632b.", "When a keyboard display switching button 9639 displayed on the touch panel is touched with a finger, a stylus, or the like, a keyboard can be displayed on the display portion 9631b.", "Touch input can be performed in the touch panel region 9632a and the touch panel region 9632b at the same time.", "The display mode changing switch 9626 allows switching between a landscape mode and a portrait mode, color display and black-and-white display, and the like.", "The power saving mode changing switch 9625 can control display luminance in accordance with the amount of external light in use of the tablet terminal 9600, which is measured with an optical sensor incorporated in the tablet terminal 9600.In addition to the optical sensor, other detecting devices such as sensors for determining inclination, such as a gyroscope or an acceleration sensor, may be incorporated in the tablet terminal.", "Although the display portion 9631a and the display portion 9631b have the same area in FIG.", "19A, one embodiment of the present invention is not limited to this example.", "The display portion 9631a and the display portion 9631b may have different areas or different display quality.", "For example, one of the display portions 9631a and 9631b may display higher definition images than the other.", "The tablet terminal is closed in FIG.", "19B.", "The tablet terminal includes the housing 9630, a solar cell 9633, and a charge and discharge control circuit 9634 including a DCDC converter 9636.The power storage unit of one embodiment of the present invention is used as the power storage unit 9635.The tablet terminal 9600 can be folded such that the housings 9630a and 9630b overlap with each other when not in use.", "Thus, the display portions 9631a and 9631b can be protected, which increases the durability of the tablet terminal 9600.In addition, the power storage unit 9635 of one embodiment of the present invention has flexibility and can be repeatedly bent without a significant decrease in charge and discharge capacity.", "Thus, a highly reliable tablet terminal can be provided.", "The tablet terminal illustrated in FIGS.", "19A and 19B can also have a function of displaying various kinds of data (e.g., a still image, a moving image, and a text image), a function of displaying a calendar, a date, or the time on the display portion, a touch-input function of operating or editing data displayed on the display portion by touch input, a function of controlling processing by various kinds of software (programs), and the like.", "The solar cell 9633, which is attached on the surface of the tablet terminal, supplies electric power to a touch panel, a display portion, an image signal processing portion, and the like.", "Note that the solar cell 9633 is preferable because it can be provided on one or both surfaces of the housing 9630 and the power storage unit 9635 can be charged efficiently.", "The use of a lithium-ion battery as the power storage unit 9635 brings an advantage such as reduction in size.", "The structure and operation of the charge and discharge control circuit 9634 illustrated in FIG.", "19B will be described with reference to a block diagram in FIG.", "19C.", "The solar cell 9633, the power storage unit 9635, the DCDC converter 9636, a converter 9637, switches SW1 to SW3, and the display portion 9631 are illustrated in FIG.", "19C, and the power storage unit 9635, the DCDC converter 9636, the converter 9637, and the switches SW1 to SW3 correspond to the charge and discharge control circuit 9634 in FIG.", "19B.", "First, an example of operation when electric power is generated by the solar cell 9633 using external light will be described.", "The voltage of electric power generated by the solar cell is raised or lowered by the DCDC converter 9636 to a voltage for charging the power storage unit 9635.When the display portion 9631 operates with the electric power from the solar cell 9633, the switch SW1 is turned on and the voltage of the electric power is raised or lowered by the converter 9637 to a voltage needed for operating the display portion 9631.When display on the display portion 9631 is not performed, the switch SW1 is turned off and the switch SW2 is turned on, so that the power storage unit 9635 can be charged.", "Note that the solar ell 9633 is described as an example of a power generation means; however, one embodiment of the present invention is not limited to this example.", "The power storage unit 9635 may be charged using another power generation means such as a piezoelectric element or a thermoelectric conversion element (Peltier element).", "For example, the power storage unit 9635 may be charged with a non-contact power transmission module capable of performing charging by transmitting and receiving electric power wirelessly (without contact), or any of the other charge means used in combination.", "FIG.", "20 illustrates other examples of electronic devices.", "In FIG.", "20, a display device 8000 is an example of an electronic device including a power storage device 8004 of one embodiment of the present invention.", "Specifically, the display device 8000 corresponds to a display device for TV broadcast reception and includes a housing 8001, a display portion 8002, speaker portions 8003, and the power storage device 8004.The power storage device 8004 of one embodiment of the present invention is provided in the housing 8001.The display device 8000 can receive electric power from a commercial power supply.", "Alternatively, the display device 8000 can use electric power stored in the power storage device 8004.Thus, the display device 8000 can operate with the use of the power storage device 8004 of one embodiment of the present invention as an uninterruptible power supply even when electric power cannot be supplied from a commercial power supply due to power failure or the like.", "A semiconductor display device such as a liquid crystal display device, a light-emitting device in which a light-emitting element such as an organic EL element is provided in each pixel, an electrophoresis display device, a digital micromirror device (DMD), a plasma display panel (PDP), or a field emission display (FED) can be used for the display portion 8002.Note that the display device includes, in its category, all of information display devices for personal computers, advertisement displays, and the like besides TV broadcast reception.", "In FIG.", "20, an installation lighting device 8100 is an example of an electronic device including a power storage device 8103 of one embodiment of the present invention.", "Specifically, the lighting device 8100 includes a housing 8101, a light source 8102, and the power storage device 8103.Although FIG.", "20 illustrates the case where the power storage device 8103 is provided in a ceiling 8104 on which the housing 8101 and the light source 8102 are installed, the power storage device 8103 may be provided in the housing 8101.The lighting device 8100 can receive electric power from a commercial power supply.", "Alternatively, the lighting device 8100 can use electric power stored in the power storage device 8103.Thus, the lighting device 8100 can operate with the use of power storage device 8103 of one embodiment of the present invention as an uninterruptible power supply even when electric power cannot be supplied from a commercial power supply due to power failure or the like.", "Note that although the installation lighting device 8100 provided in the ceiling 8104 is illustrated in FIG.", "20 as an example, the power storage device of one embodiment of the present invention can be used in an installation lighting device provided in, for example, a wall 8105, a floor 8106, a window 8107, or the like other than the ceiling 8104.Alternatively, the power storage device of one embodiment of the present invention can be used in a tabletop lighting device or the like.", "As the light source 8102, an artificial light source which emits light artificially by using electric power can be used.", "Specifically, an incandescent lamp, a discharge lamp such as a fluorescent lamp, and light-emitting elements such as an LED and an organic EL element are given as examples of the artificial light source.", "In FIG.", "20, an air conditioner including an indoor unit 8200 and an outdoor unit 8204 is an example of an electronic device including a power storage device 8203 of one embodiment of the present invention.", "Specifically, the indoor unit 8200 includes a housing 8201, an air outlet 8202, and the power storage device 8203.Although FIG.", "20 illustrates the case where the power storage device 8203 is provided in the indoor unit 8200, the power storage device 8203 may be provided in the outdoor unit 8204.Alternatively, the power storage devices 8203 may be provided in both the indoor unit 8200 and the outdoor unit 8204.The air conditioner can receive electric power from a commercial power supply.", "Alternatively, the air conditioner can use electric power stored in the power storage device 8203.Particularly in the case where the power storage devices 8203 are provided in both the indoor unit 8200 and the outdoor unit 8204, the air conditioner can operate with the use of the power storage device 8203 of one embodiment of the present invention as an uninterruptible power supply even when electric power cannot be supplied from a commercial power supply due to power failure or the like.", "Note that although the split-type air conditioner including the indoor unit and the outdoor unit is illustrated in FIG.", "20 as an example, the power storage device of one embodiment of the present invention can be used in an air conditioner in which the functions of an indoor unit and an outdoor unit are integrated in one housing.", "In FIG.", "20, as electric refrigerator-freezer 8300 is an example of an electronic device including a power storage device 8304 of one embodiment of the present invention.", "Specifically, the electric refrigerator-freezer 8300 includes a housing 8301, a refrigerator door 8302, a freezer door 8303, and the power storage device 8304.The power storage device 8304 is provided in the housing 8301 in FIG.", "20.The electric refrigerator-freezer 8300 can receive electric power from a commercial power supply.", "Alternatively, the electric refrigerator-freezer 8300 can use electric power stored in the power storage device 8304.Thus, the electric refrigerator-freezer 8300 can operate with the use of the power storage device 8304 of one embodiment of the present invention as an uninterruptible power supply even when electric power cannot be supplied from a commercial power supply due to power failure or the like.", "Note that among the electronic devices described above, a high-frequency heating apparatus such as a microwave oven and an electronic device such as an electric rice cooker require high power in a short time.", "The tripping of a breaker of a commercial power supply in use of an electronic device can be prevented by using the power storage device of one embodiment of the present invention as an auxiliary power supply for supplying electric power which cannot be supplied enough by a commercial power supply.", "In addition, in a time period when electronic devices are not used, particularly when the proportion of the amount of electric power which is actually used to the total amount of electric power which can be supplied from a commercial power supply source (such a proportion referred to as a usage rate of electric power) is low, electric power can be stored in the power storage device, whereby the usage rate of electric power can be reduced in a time period when the electronic devices are used.", "For example, in the case of the electric refrigerator-freezer 8300, electric power can be stored in the power storage device 8304 in nighttime when the temperature is low and the refrigerator door 8302 and the freezer door 8303 are not often opened or closed.", "On the other hand, in daytime when the temperature is high and the refrigerator door 8302 and the freezer door 8303 are frequently opened and closed, the power storage device 8304 is used as an auxiliary power supply; thus, the usage rate of electric power in daytime can be reduced.", "This embodiment can be implemented in combination with any of the other embodiments as appropriate.", "Embodiment 6 In this embodiment, examples of vehicles using power storage devices will be described, The use of power storage devices in vehicles enables production of next-generation clean energy vehicles such as hybrid electric vehicles (HEVs), electric vehicles (EVs), and plug-in hybrid electric vehicles (PHEVs).", "FIGS.", "21A and 21B each illustrate an example of a vehicle using one embodiment of the present invention.", "An automobile 8400 illustrated in FIG.", "21A is an electric vehicle that runs on the power of an electric motor.", "Alternatively, the automobile 8400 is a hybrid electric vehicle capable of driving appropriately using either the electric motor or the engine.", "One embodiment of the present invention can provide a high-mileage vehicle.", "The automobile 8400 includes the power storage device.", "The power storage device is used not only for driving the electric motor, but also for supplying electric power to a light-emitting device such as a headlight 8401 or a room light (not illustrated).", "The power storage device can also supply electric power to a display device of a speedometer, a tachometer, or the like included in the automobile 8400.Furthermore, the power storage device can supply electric power to a semiconductor device included in the automobile 8400, such as a navigation system.", "FIG.", "21B illustrates an automobile 8500 including a power storage device 8024.The automobile 8500 can be charged when the power storage device 8024 is supplied with electric power through external charging equipment by a plug-in system, a contactless power charging system, or the like.", "In FIG.", "21B, the power storage device 8024 included in the automobile 8500 is charged with the use of a ground-based charging apparatus 8021 through a cable 8022.In charging, a given method such as CHAdeMO (registered trademark) or Combined Charging System may be employed as a charging method, the standard of a connector, or the like as appropriate.", "The ground-based charging apparatus 8021 may be a charging station provided in a commerce facility or a power source in a house.", "For example, with the use of a plug-in technique, the power storage device 8024 included in the automobile 8500 can be charged by being supplied with electric power from outside.", "The charging can be performed by converting AC electric power into DC electric power through a converter such as an AC-DC converter.", "Furthermore, although not illustrated, the vehicle may include a power receiving device so that it can be charged by being supplied with electric power from an above-ground power transmitting device in a contactless manner.", "In the case of the contactless power feeding system, by fitting a power transmitting device in a road or an exterior wall, charging can be performed not only when the electric vehicle is stopped but also when driven.", "In addition, the contactless power feeding system may be utilized to perform transmission and reception of electric power between vehicles.", "Furthermore, a solar cell may be provided in the exterior of the automobile to charge the power storage device when the automobile stops or moves.", "To supply electric power in such a contactless manner, an electromagnetic induction method or a magnetic resonance method can be used.", "According to one embodiment of the present invention, the power storage device can have improved cycle characteristics and reliability.", "Furthermore, according to one embodiment of the present invention, the power storage device itself can be made more compact and lightweight as a result of improved characteristics of the power storage device.", "The compact and lightweight power storage device contributes to a reduction in the weight of a vehicle, and thus increases the driving distance.", "Furthermore, the power storage device included in the vehicle can be used as a power source for supplying electric power to products other than the vehicle.", "In such a case, the use of a commercial power source can be avoided at peak time of electric power demand.", "This embodiment can be implemented in appropriate combination with any of the other embodiments.", "EXAMPLE 1 In this example, an active material was formed by the method described in Embodiment 1.Measurement results of the characteristics of a battery including an electrode containing the active material will be described.", "<Synthesis of Lithium-Manganese Composite Oxide> First, Li2CO3, MnCO3, and NiO were weighed as starting materials so that the ratio for weighing (molar ratio) of Li2CO3 to MnCO3 and NiO becomes 0.84:0.8062:0.318.Then, ethanol was added to the starting materials.", "After that, ethanol and the starting materials were mixed for 30 minutes in a chamber of a bead mill rotating at a peripheral speed of 10 m/s to obtain a mixed material.", "Next, heat treatment was performed on the mixed material at 75° C. in an air atmosphere so that ethanol contained in the mixed material was evaporated; thus, a mixed material was obtained.", "Subsequently, the mixed material was put in a crucible and firing was performed at 1000° C. in an air gas (dry air) atmosphere at a flow rate of 10 L/min for 10 hours, whereby lithium-manganese composite oxides were synthesized.", "The lithium-manganese composite oxides were a plurality of primary particles sintered to be large secondary particles.", "Then, crushing treatment was performed to separate the sintered lithium-manganese composite oxides.", "In crushing treatment, after ethanol was added to the sintered lithium-manganese composite oxides, crushing and grinding were performed for 10 hours in a chamber of a bead mill rotating at a peripheral speed of 4 m/s; as a result, a powdery lithium-manganese composite oxide was obtained.", "After that, heat treatment was performed on the lithium-manganese composite oxides subjected to the crushing treatment.", "The heat treatment was performed at 75° C. in an air atmosphere so that ethanol was evaporated; thus, a powdery lithium-manganese composite oxide (sample A) was obtained.", "Although this lithium-manganese composite oxide is represented by a composition formula Li1.68Mn0.8062Ni0.318O3, the composition might be different.", "<Cross-Sectional TEM Photograph> Next, the powdery lithium-manganese composite oxide was sliced using a focused ion beam system (FIB) and then a cross section thereof was observed with a transmission electron microscope (TEM).", "FIG.", "22 shows the TEM observation result.", "As shown in FIG.", "22, the lithium-manganese composite oxides subjected to the crushing treatment are aggregates of the primary particles and powder of particles as small as the primary particle.", "FIGS.", "23A and 23B shows observation results at higher magnification than FIG.", "22.FIG.", "23A is an enlarged photograph of a particle A in FIG.", "22 and FIG.", "23B is an enlarged photograph of a particle B in FIG.", "22.As shown in FIG.", "23A, one primary particle is cleaved.", "Furthermore, as shown in FIG.", "23B, another primary particle has a linear crack.", "FIGS.", "23A and 23B indicate that some sintered primary particles are cleaved by the crushing treatment.", "<Electron Diffraction Method> Next, measurement results of crystal orientation in the lithium-manganese composite oxide obtained by an electron diffraction method will be described.", "As pretreatment, the lithium-manganese composite oxide was sliced using a focused ion beam system (FIB) and then a cross section thereof was observed with a transmission electron microscope (TEM).", "FIG.", "24A shows a cross-sectional TEM observation result.", "After that, an electron diffraction measurement of a region surrounded by a dotted line in FIG.", "24A (approximately 0.3 μmϕ) was performed.", "FIG.", "24B shows the result of the electron diffraction measurement.", "A diffraction pattern in FIG.", "24B indicates that the lattice spacing (d value) of a diffraction spot a is 0.232 nm, the d value of a diffraction spot b is 0.183 nm, and the d value of a diffraction spot c is 0.453 nm.", "The diffraction pattern also indicates that ∠aob is 21.8°, ∠aoc is 71.3°, and ∠boc is 50.5°.", "Note that according to a database, the d value of a (200) plane of Li2MnO3 (84-1634) obtained by electron beam incident in a [010] direction is 0.233 nm, the d value of a (201) plane is 0.185 nm, the d value of a (001) plane is 0.474 nm, ∠aob is 21.6°, ∠aoc is 70.5°, and ∠boc is 48.8°, whereas the d value of a (13-1) plane obtained by electron beam incident in a [013] direction is 0.233 nm, the d value of a (23-1) plane is 0.185 nm, the d value of a (100) plane is 0.465 nm, ∠aob is 21.9°, ∠aoc is 70.3°, and ∠boc is 48.3°.", "The comparison of the values obtained by the result in FIG.", "24B and the values in the database suggests that the crystal plane of the cleavage plane of the lithium-manganese composite oxide is the (100) plane or the (001) plane.", "EXAMPLE 2 In this example, results of scanning transmission electron microscopy (STEM) and electron energy-loss spectroscopy (EELS) performed on the powdery lithium-manganese composite oxide formed in Example 1 on which a layer containing carbon was formed will be described.", "First, 0.03 g of graphene oxide and 5 g of water were mixed in a mixer to form a dispersion solution of the graphene oxide.", "In the mixing, ⅕ of the water was used in the first mixing, another ⅕ of the water was added in the second mixing, another ⅕ of the water was added in the third mixing, and ⅖ of the water was added in the fourth mixing.", "Five-minute mixing was performed at 2000 rpm four times.", "Next, 15 g of the lithium manganese composite oxide obtained in Example 1 (sample A) and 4.0 g of water were put in the formed aqueous dispersion solution, and the mixture was kneaded four times.", "Five-minute kneading was performed at 2000 rpm in a mixer four times.", "The obtained mixture was dried under reduced pressure in a bell jar at 50° C. and then ground in an alumina mortar, so that the lithium manganese composite oxide covered with graphene oxide was obtained.", "Then, the graphene oxide covering the surface of the lithium manganese composite oxide was reduced.", "Ascorbic acid was used as a reducing agent, and an ethanol water solution at a concentration of 80% was used as a. solvent.", "After that, 16.87 wt % of the ascorbic acid and 3.9 wt % of lithium hydroxide, the weight percentages were with respect to the weight of the lithium-manganese composite oxides covered with graphene oxide, were put and a reducing solution was formed.", "The obtained powder was put in the reducing solution, and reduction was performed at 60° C. for 3 hours.", "Then, the obtained solution was filtrated by suction filtration.", "For the filtration, filter paper with a particle retention capability of 1 μm was used.", "After that, washing and another filtration were performed, and the resulting powder was ground in a mortar.", "After that, drying was performed at 170° C. under reduced pressure for 10 hours.", "Through the above steps, a powdery lithium-manganese composite oxide (sample B) in which graphene was formed on a surface was formed.", "FIG.", "25 shows a result of STEM observation performed on the lithium-manganese composite oxide in which graphene was formed on the surface.", "An EELS analysis was also performed on a region on which the STEM observation was performed.", "FIG.", "26 to FIG.", "28 show EELS analysis results of the same portion as that of the observation image in FIG.", "25.FIG.", "26 is an analysis result of carbon, FIG.", "27 is an analysis result of oxygen, and FIG.", "28 is an analysis result of manganese.", "FIG.", "29A shows a portion subjected to a linear analysis, and FIG.", "29B shows linear analysis results of C, O, and Mn.", "In FIG.", "29B, a solid line 151, a solid line 152, and a solid line 153 indicate the linear analysis result of C, the linear analysis result of O, and the linear analysis result of Mn, respectively.", "FIGS.", "29A and 29B suggest that there is a region in a film form that contains C and O and is in contact with the lithium-manganese composite oxide.", "EXAMPLE 3 In this example, measurement results of the cycle characteristics of half cells, which were fabricated using electrodes containing the active material of one embodiment of the present invention, will be described.", "Table 1 shows components of the electrodes and the half cells used in tins example.", "TABLE 1 Active Conductive Cell Electrode material additive Binder Ratio [wt %] Half Comparative Comparative Sample A AB PVdF Sample A:AB:PVdF = cell cell A electrode A 90:5:5 Cell B Electrode B Sample B AB PVdF Sample B:AB:PVdF = 90:5:5 Cell C Electrode C Sample C AB PVdF Sample C:AB:PVdF = 90:5:5 Cell D Electrode D Sample D AB PVdF Sample D:AB:PVdF = 90:5:5 Cell E Electrode E Sample E AB PVdF Sample E:AB:PVdF = 90:5:5 First, a comparative electrode A, an electrode B, an electrode C, an electrode D, and an electrode E used to fabricate the half cells will be described.", "The sample A formed in Example 1 was used as an active material of the comparative electrode A, and the sample B formed in Example 2 was used as an active material of the electrode B.", "Here, samples C to E which were used as active materials of the electrodes C to E will be described.", "A powdery lithium-manganese composite oxide was formed in a manner similar to that of the sample A described in Example 1.After that, heat treatment was performed on the powdery lithium-manganese composite oxide in an air gas (dry air) atmosphere at a flow rate of 10 L/min for 10 hours.", "The heating temperatures were set to 600° C., 700° C., and 800° C. Then, the powdery lithium-manganese composite oxide subjected to the heat treatment was covered with graphene in a manner similar to that in Example 2.The lithium-manganese composite oxides formed at a heating temperature of 600° C., 700° C., and 800° C. were the sample C, the sample D, and the sample E, respectively.", "Here, a method for forming the electrode B including the sample B is described.", "To form the electrode B, the sample B described in Example 2 was used as an active material, acetylene black (AB) was used as a conductive additive, and PVdF was used as a binder.", "First, PVdF which was a binder and acetylene black (AB) which was a conductive additive were mixed with N-methyl-2-pyrrolidone (NMP) which was a polar solvent.", "Note that five-minute mixing was performed at 2000 rpm five times.", "Then, the sample B was added as an active material and five-minute mixing was performed at 2000 rpm five times.", "After that, NMP was added and ten-minute mixing was performed at 2000 rpm twice.", "Through the above steps, a slurry electrode binder composition was obtained.", "The compounding ratio of the sample B to AB and PVdF in the electrode binder composition was 90:5:5 (weight ratio).", "Next, the electrode binder composition was applied to aluminum foil which was a current collector.", "Note that a surface of the aluminum foil was covered with an undercoat in advance.", "After that, drying was performed at 80° C. for 30 minutes in a circulation drying furnace.", "An electrode formed through the above steps was the electrode B.", "Then, the electrode was pressed with a roller press machine while the press pressure was adjusted so that the thickness after application of the electrode binder composition was reduced by 20%.", "The press temperature was 120° C. As the comparative electrode A, an electrode was formed using the sample A described in Example 1.The comparative electrode A was formed in the same manner as the electrode B except that the sample A was used as an active material.", "The electrodes C to E were formed using the samples C to E. The electrode C was formed in the same manner as the electrode B except that the sample C was used as an active material.", "The electrode D was formed in the same manner as the electrode B except that the sample D was used as an active material.", "The electrode E was formed in the same manner as the electrode B except that the sample E was used as an active material.", "Next, a half cell was fabricated using the electrode B as a positive electrode.", "For the cell, a coin cell was used.", "Lithium was used for a counter electrode of the half cell.", "An electrolytic solution was formed by dissolving LiPF6 as an electrolyte in a mixed solution containing ethylene carbonate and diethyl carbonate, which are aprotic organic solvents, at a volume ratio of 1:1.As the separator, polypropylene (PP) was used.", "A half cell fabricated using the electrode B was a cell B.", "A half cell was fabricated using the comparative electrode A as a positive electrode.", "The comparative half cell was fabricated in the same manner as the cell B except that the comparative electrode A was used as a positive electrode.", "The half cell fabricated using the comparative electrode A is a comparative cell A.", "Cells C to E were fabricated using the electrodes C to E. The cell C was formed in the same manner as the cell B except that the electrode C was used as a positive electrode.", "The cell D was formed in the same manner as the cell B except that the electrode D was used as a positive electrode.", "The cell E was formed in the same manner as the cell B except that the electrode E was used as a positive electrode.", "Then, the cycle characteristics of the comparative cell A and the cells B to E were measured.", "In a cycle test, constant current charging was performed with a current density per active material weight of 30 mA/g until the voltage reached a termination voltage of 4.8 V. Constant current discharging was performed with a current density of 30 mA/g until the voltage reached a termination voltage of 2.0 V. The temperature during the charging and discharging was 25° C. In the cycle test, constant current charging and discharging were repeated.", "FIGS.", "30A and 30B show the charge-discharge cycle characteristics of the comparative cell A and the cells B to E. In FIGS.", "30A and 30B, a longitudinal axis represents discharge capacity (mAh/g) and a lateral axis represents the number of cycles (times).", "Here, capacity was normalized by the weight of the positive electrode active material.", "In FIGS.", "30A and 30B, a plot of the cell B is indicated by open circles, a plot of the comparative cell A is indicated by crosses, a plot of the cell C is indicated by black triangles, a plot of the cell D is indicated by black squares, and a plot of the cell E is indicated by black circles.", "Note that FIG.", "30A shows discharge capacity greater than or equal to 0 mAh/g and less than or equal to 350 mAh/g, and FIG.", "30B shows discharge capacity greater than or equal to 240 mAh/g and less than or equal to 300 mAh/g.", "As shown in FIG.", "30A, the discharge capacity of the comparative cell A decreases after the third cycle whereas the discharge capacity of the cell 13 does not greatly change even after the fifteenth cycle.", "In addition, as shown in FIG.", "30B, the discharge capacity of each of the cells C to E is greater than that of the cell B.", "FIG.", "31 shows the charge and discharge characteristics of the comparative cell A and the cells B to E after the fifth cycle.", "In FIG.", "31, a longitudinal axis represents voltage (V) and a lateral axis represents capacity (mAh/g).", "In FIG.", "31, a dashed-clotted line indicates the charge and discharge characteristics of the cell B, a dotted line indicates the charge and discharge characteristics of the comparative cell A, a two-dot chain line indicates the charge and discharge characteristics of the cell C, a dashed line indicates the charge and discharge characteristics of the cell D, and a solid line indicates the charge and discharge characteristics of the cell E. As shown in FIG.", "31, although the discharge capacity of the comparative cell A decreases to less than 200 mAh/g, the discharge capacity of each of the cells B to E is greater than or equal to 250 mAh/g.", "The results in FIGS.", "30A and 30B and FIG.", "31 indicate that owing to the lithium-manganese composite oxides covered with graphene, the capacity is increased and the cycle characteristics are improved.", "The results also indicate that heat treatment after the crushing treatment further increases the capacity and further improves the cycle characteristics, EXAMPLE 4 In this example, measurement results of the cycle characteristics of full cells, which were fabricated using electrodes containing the active material of one embodiment of the present invention, will be described.", "Table 2 shows components of the positive electrodes and the full cells used in this example.", "TABLE 2 Active Conductive Cell Electrode material additive Binder Ratio [wt %] Full Cell F Electrode F Sample B AB PVdF Sample B:AB:PVdF = cell 90:5:5 Comparative Comparative Sample A AB PVdF Sample A:AB:PVdF = cell G electrode G 90:5:5 Cell H Electrode H Sample F AB PVdF Sample F:AB:PVdF = 90:5:5 First, a method for fabricating a sample F used in this example will be described.", "<Synthesis of Lithium-Manganese Composite Oxide> First, Li2CO3, MnCO3, and NiO were weighed as starting materials so that the ratio for weighing (molar ratio) of Li2CO3 to MnCO3 and NiO becomes 0.84:0.8062:0.318.Then, NiO was ground with a bead mill.", "The grinding treatment was performed for 30 minutes in a chamber of the bead mill rotating at a peripheral speed of 12 m/s.", "After that, Li2CO3 and MnCO3 were added to NiO.", "Subsequently, Li2CO3, MnCO3, and NiO were mixed for 30 minutes in a chamber of a head mill rotating at a peripheral speed of 10 m/s to obtain a mixed material.", "Next, heat treatment was performed on the mixed material at 75° C. in an air atmosphere so that ethanol contained in the mixed material was evaporated; thus, a mixed material was obtained.", "Subsequently, the mixed material was put in a crucible and firing was performed at 1000° C. in an air gas (dry air) atmosphere at a flow rate of 10 L/min for 10 hours, whereby lithium-manganese composite oxides were synthesized.", "Then, crushing treatment was performed to separate the sintered lithium-manganese composite oxides.", "In crushing treatment, after ethanol was added to the sintered lithium-manganese composite oxides, crushing and grinding were performed for 35 hours in a chamber of a bead mill rotating at a peripheral speed of 4 m/s; as a result, a powdery lithium-manganese composite oxide was obtained.", "After that, heat treatment was performed on the lithium-manganese composite oxides subjected to the crushing treatment, at 800° C. in an air gas (dry air) atmosphere at a flow rate of 10 L/min for 3 hours.", "Although this lithium-manganese composite oxide is represented by a composition formula Li1.68Mn0.8062Ni0.3118O3, the composition might be different.", "Then, 0.03 g of graphene oxide and 5 g of water were mixed in a mixer to form a dispersion solution of the graphene oxide.", "In the mixing, ⅕ of the water was used in the first mixing, another ⅕ of the water was added in the second mixing, another ⅕ of the water was added in the third mixing, and ⅖ of the water was added in the fourth mixing.", "Five-minute mixing was performed at 2000 rpm four times.", "Next, 15 g of the lithium manganese composite oxide and 4.0 g of water were put in the formed aqueous dispersion solution, and the mixture was kneaded four times.", "Five-minute kneading was performed at 2000 rpm in a mixer four times.", "The obtained mixture was dried under reduced pressure in a bell jar at 50° C. and then ground in an alumina mortar, so that the lithium manganese composite oxide covered with graphene oxide was obtained.", "Then, the graphene oxide covering the surface of the lithium manganese composite oxide was reduced.", "Ascorbic acid was used as a reducing agent, and an ethanol water solution at a concentration of 80% was used as a solvent.", "After that, 16.3 wt % of the ascorbic acid and 3.9 wt % of lithium hydroxide, the weight percentages were with respect to the weight of the lithium-manganese composite oxides covered with graphene oxide, were put and a reducing solution was formed.", "The obtained powder was put in the reducing solution, and reduction was performed at 60° C. for 3 hours.", "Then, the obtained dispersion liquid was filtrated by suction filtration.", "For the filtration, filter paper with a particle retention capability of 1 μm was used.", "After that, washing and another filtration were performed.", "Next, pure water was added to the substance from which the solvent was separated to obtain a dispersion liquid at a concentration of 15 g/l.", "Subsequently, the obtained dispersion liquid was heated at 60° C., supplied to a spray dryer device, and subjected to spray dry treatment at 150° C. Then, powder obtained by the spray dry treatment as dried at 170° C. under reduced pressure for 10 hours.", "Through the above steps, a powdery lithium-manganese composite oxide (sample F) in which graphene was formed on a surface was formed.", "Here, a method for forming an electrode F including the sample B is described.", "To form the electrode F, the sample B was used as an active material, acetylene black was used as a conductive additive, and PVdF was used as a binder.", "First, PVdF which was a binder and acetylene black (AB) which was a conductive additive were mixed with N-methyl-2-pyrrolidone (NMP) which was a polar solvent.", "Note that five-minute mixing was performed at 2000 rpm five times.", "Then, the sample B was added as an active material and five-minute mixing was performed at 2000 rpm five times.", "After that, NMP was added and ten-minute mixing was performed at 2000 rpm twice.", "Through the above steps, a slimy electrode binder composition was obtained.", "The compounding ratio of the sample B to AB and PVdF in the electrode binder composition was 90:5:5 (weight ratio).", "Next, the electrode binder composition was applied to aluminum foil which was a current collector.", "Note that a surface of the aluminum foil was covered with an undercoat in advance.", "After that, drying was performed at 80° C. for 30 minutes in a circulation drying furnace.", "Then, the electrode was pressed with a roller press machine while the press pressure was adjusted so that the thickness after application of the electrode binder composition was reduced by 20%.", "The press temperature was 120° C. After that, another heat treatment as performed at 250° C. in a reduced pressure atmosphere (1 kPa) for 10 hours.", "Through the above process, the electrode F including the sample B was formed.", "A comparative electrode G was formed using the sample A in a manner similar to that of the comparative electrode A.", "An electrode H was formed using the sample F. The electrode H was formed under the same conditions as the electrode F except that the sample B in the electrode F was changed to the sample F. Then, a negative electrode in the full cell was formed.", "First, MCMB graphite was used as an active material, VGCF was used as a conductive additive, and CMC and SBR were used as binders to form a paste electrode binder composition in which the weight ratio of MCMB graphite to VGCF, CMC, and SBR was 96:1:1:2.Pure water was used as a solvent of the electrode binder composition.", "In forming the electrode binder composition, MCMB graphite with the film containing silicon oxide, VGCF, and a small amount of pure water were mixed first, an aqueous solution where CMC was uniformly dissolved in pure water was added to the mixture, and then mixing was performed.", "The mixing was performed with a planetary mixer.", "Then, an SBR dispersion liquid was added to the mixture, and mixing was performed with a mixer.", "Pure water was then added to the mixture until a predetermined viscosity as obtained, and mixing was performed with a mixer for 5 minutes twice.", "Subsequently, the electrode binder composition was applied to a current collector with the use of a blade and then dried.", "For the drying, the surface of the paste was dried at 30° C. in an air atmosphere and then the temperature was raised to 50° C., and the surface of the slurry was further dried at 100° C. in a reduced pressure atmosphere for ten hours.", "As the current collector, 18-μm-thick rolled copper foil was used.", "Through the above steps, the negative electrode was formed.", "Next, single-layer thin storage batteries (full cells) were fabricated using the formed positive and negative electrodes.", "An aluminum film covered with a heat sealing resin was used as an exterior body.", "The electrolytic solution was formed in such a manner that an additive such as VC or PS was added to a solvent mainly containing EC, DEC, and ethyl methyl carbonate (EMC).", "As each separator, 25-μm-thick polypropylene (PP) was used.", "A full cell fabricated using the electrode F as a positive electrode was a cell F, a full cell fabricated using the comparative electrode G as a positive electrode was a cell G, and a full cell fabricated using the electrode H as a positive electrode was a cell H. The cell F, the comparative cell G, and the cell H were subjected to aging.", "Note that rates were calculated using 240 mAh/g as a reference.", "First, charging was performed at 0.01 C with the upper voltage limit set to 4.0 V, and then degassing was performed to reseal.", "After that, discharging was performed at 0.1 C with the lower voltage limit set to 2 V, charging was performed at 0.01 C with the upper voltage limit set to 4.1 V, discharging was performed at 0.1 C with the lower voltage limit set to 2 V, charging was performed at 0.01 C with the upper voltage limit set to 4.2 V, discharging was performed at 0.1 C with the lower voltage limit set to 2 V, charging was performed at 0.01 C with the upper voltage limit set to 4.3 V, discharging was performed at 0.1 C with the lower voltage limit set to 2 V, charging was performed at 0.01 C with the upper voltage limit set to 4.4 V, discharging was performed at 0.1 C with the lower voltage limit set to 2 V, charging was performed at 0.01 C with the upper voltage limit set to 4.5 V, discharging was performed at 0.1 C with the lower voltage limit set to 2 V charging was performed at 0.01 C with the upper voltage limit set to 4.6 V, and discharging was performed at 0.1 C with the lower voltage limit set to 2 V. Then, degassing was performed again to reseal.", "After the aging, the cycle characteristics of the cell F, the comparative cell G, and the cell H were measured.", "Constant current charging and discharging at a rate of 0.2 C were repeated for a cycle test.", "In the cycle test, charging and discharging were repeated 50 times with the upper voltage limit set to 4.6 V and the lower voltage limit set to 2 V. Note that rates were calculated using 184.40 mAh/g as a reference when the electrode F or the electrode H was used as the positive electrode and 192.05 mAh/g as a reference when the comparative electrode G was used as the positive electrode.", "FIG.", "32 is a plot of a change in capacity associated with the number of cycles.", "In FIG.", "32, a longitudinal axis represents discharge capacity (mAh/g) and a lateral axis represents the number of cycles (times).", "Here, capacity was normalized by the weight of the positive electrode active material.", "In FIG.", "32, a plot of the cell F is indicated by open circles, a plot of the comparative cell G is indicated by crosses, and a plot of the cell H is indicated by black circles.", "As shown in FIG.", "32, a reduction rate of the discharge capacity of the cell H is the lowest and a reduction rate of the discharge capacity of the cell F is lower than that of the discharge capacity of the comparative cell G. The above results indicate that forming graphene on the surfaces of the lithium-manganese composite oxides after the crushing and grinding in the method for forming the lithium-manganese composite oxides can lower a reduction rate of the discharge capacity associated with the number of cycles.", "EXAMPLE 5 In this example, a result of an x-ray absorption fine structure (XAFS) analysis performed on a battery including the electrode containing the sample A described in Example 1 will be described.", "In addition, the calculation results of examination of Li2MnO3 that does not contain Ni will be described.", "For the examination, differential charge density before and after Li deintercalation was measured to determine whether O compensates charges and whether Li deintercalation promotes oxygen deintercalation.", "Table 3 shows components of the electrodes and the half cells used in this example.", "TABLE 3 Active Conductive Cell Electrode material additive Binder Ratio [wt %] Half Cell I1 Electrode I1 Sample A AB PVdF Sample A:AB:PVdF = cell 90:5:5 Cell I2 Electrode I2 Sample A AB PVdF Sample A:AB:PVdF = 90:5:5 Cell I3 Electrode I3 Sample A AB PVdF Sample A:AB:PVdF = 90:5:5 Electrodes I1 to I3 used in this example will be described.", "The sample A described in Example 1 was used as an active material of the electrodes I1 to I3.Furthermore, the electrodes I1 to I3 were formed in a manner similar to that of the comparative electrode A described in Example 3.Next, a cell I1 and a cell I2 were fabricated using the electrode I1 and the electrode I2, respectively.", "The cells I1 and I2 were fabricated in a manner similar to that of the comparative cell A described in Example 3.Then, the cell I1 was charged at 25° C. at a constant current with a current density per active material weight of 30 mA/g until the voltage reached a termination voltage of 4.8 V. The cell I2 was charged at 25° C. at a constant current with a current density per active material weight of 30 mA/g until the voltage reached a termination voltage of 4.8 V, and discharged at a constant current with a current density of 30 mA/g until the voltage reached a termination voltage of 2.0 V. After that, the cell I1 and the cell I2 were disassembled in a glove box to take out the electrode I1 and the electrode I2.Next, the electrodes I1 to I3 were subjected to an XAFS measurement.", "In the XAFS measurement, data of a surface of the lithium manganese oxide (sample A) was obtained by a total electron yield (TEY) method, and data of bulk of the lithium manganese oxide (sample A) was obtained by a partial fluorescent yield (PFY) method.", "Note that the electrode I3 was used as a reference.", "FIG.", "33A shows the oxygen Kedge spectra obtained by a TEY method, and FIG.", "33B shows the oxygen K-edge spectra obtained by a PFY method.", "FIG.", "34A shows the nickel L-edge spectra obtained by a TEY method, and FIG.", "34B shows the nickel L-edge spectra obtained by a PFY method.", "As shown in FIGS.", "33A and 33B, both on the surface and in the bulk, a peak at around 540 eV shifts toward the high-energy side after charging and the metal-O bond length becomes short, and it is likely to cancel after discharging.", "In addition, changes in two peak intensities in FIGS.", "34A and 34B indicate that the valence number of a metal (Ni) is likely to increase after charging and decrease after discharging both on the surface and in the bulk.", "In FIG.", "33A, the peak intensity after charging is lower than that of the reference, which suggests that oxygen deintercalation might occur.", "In FIG.", "33B, there is not significant difference in the peak intensity after discharging and that of the reference.", "When a change in the K-edge of an O atom due to discharging in the sample A (Li1.68Mn0.8062M0.318O3) described in Example 1 is examined by an XAFS measurement, a change in pre-edge peak as shown in FIGS.", "33A and 33B suggests that some O atoms might be released during discharging.", "Thus, to examine Li2MnO3 that does not contain Ni by calculation, differential charge density before and after Li deintercalation was measured to determine whether O compensates charges and whether Li deintercalation promotes oxygen deintercalation.", "The differential charge density can be an indicator for identifying a charge compensation source.", "Here, the differential charge density is a difference in electron density distribution before and after Li deintercalation.", "An atom that compensates charges and an orbital of an electron that compensates charges can be confirmed by the measurement of the differential charge density.", "<Measurement of Differential Charge Density> In this example, location dependence of charge compensation of Li2MnO3 (layered rock salt structure) and location dependence of Li deintercalation were verified.", "It was found that a charge compensation source is not a Mn atom but the 2p orbital of an O atom around a deintercalated Li atom.", "The analysis of the K-edge of a Mn atom by XAFS measurement also showed that a Mn atom does not compensate charges.", "In addition, energy comparison at the time of Li deintercalation revealed that some Li atoms are more likely to deintercalate than the others.", "Table 4 shows the calculation conditions.", "FIG.", "35 illustrates a structure of an active material (Li2MnO3) used for the calculation.", "TABLE 4 Software VASP Model Li2MnO3 (24 atoms) Functional HSE06 Mixture ratio of exchange 0.25 terms Pseudo potential PAW Cut-off energy 800 V k-point 2 × 1 × 2 (Single point calculation) In FIG.", "35, symmetry atoms are denoted by the same number.", "According to FIG.", "35, three positions of Li should be examined.", "Hereinafter, a structure obtained by deintercalation of one Li atom at Li1, a structure obtained by deintercalation of one Li atom at Li2, and a structure obtained by deintercalation of one Li atom at Li3 are called Structure 1, Structure 2, and Structure 3, respectively, for convenience.", "First, energy at the time of Li deintercalation was compared to determine which of Structures 1 to 3 is stable.", "FIG.", "36 shows the comparison results.", "FIG.", "36 shows that Structures 2 and 3 have lower energy than Structure 1 does and thus are more stable than Structure 1.This means that deintercalation of an Li atom at Li1 from Li2MnO3 requires high energy.", "Thus, deintercalation of an Li atom at Li1 is probably less likely to occur.", "To identify the charge compensation source, the differential charge densities of the structures (Structures 2 and 3) each obtained by Li deintercalation at Li2 or Li3 where Li deintercalation is considered to occur easily were calculated.", "FIGS.", "37A and 37B show results of Structure 2 and FIG.", "38 shows results of Structure 3.FIGS.", "37A and 37B illustrate the same structure seen from different directions.", "Since FIGS.", "37A and 37B illustrate a wider region than a unit cell, two deintercalated Li atoms are shown: however, only one Li atom is deintercalated per unit cell.", "FIGS.", "37A and 37B and FIG.", "38 show that in the case of Li deintercalation, not a Mn atom but an O atom around the deintercalated Li atom compensates charges in each structure.", "The shape of an isosurface of the differential charge density indicates that the charge compensation source is probably the 2p orbital of an O atom.", "<Measurement of Deintercalation Energy of O> Next, the easiness of oxygen deintercalation from Li(2-x)MnO3, which was obtained by Li deintercalation from Li2MnO3 was measured.", "The formation energy defined as follows was used to determine how easily oxygen vacancies are generated.", "A→B+C⇒Eform(B)=E(B)+E(C)−E(A) [Formula 1] The above formula indicates that as the value of Eform(B) becomes smaller, a substance B becomes more easily to be formed as a result of a reaction “A→B+C.” The formation energy of an oxygen vacancy in the lithium-manganese composite oxide Li2MnO3 having a layered rock-salt crystal structure was measured by the electronic structure calculation package VASP.", "The cut-off energy was 800 eV, and the effect of functional/inner-shell-electron was calculated by HSE06/PAW.", "To measure the formation energy of an oxygen vacancy with respect to the composition of Li, the formation energy of an oxygen vacancy in Li4MnO3 was measured within a range where a is from 1.0 to 2.0.In the case where a is 2, Li2MnO3 including 96 atoms (32 Li atoms, 16 Mn atoms, and 48 O atoms) was used as a model structure, whereas in the case where a is smaller than 2, a structure in which Li atoms were deintercalated depending on the composition was used.", "FIG.", "39 illustrates the structure of a unit cell of Li2MnO3.The following reaction was assumed as an example for the formation energy of an oxygen vacancy in Li2MnO3.?", "   Li 32  Mn 16  O 48  ?", " Mn 16  O 47 + ?", " O 2   ?", " indicates text missing or illegible when filed [ Formula   2 ] Note that in the above formula, the relaxation energy at an atomic position is not taken into consideration.", "Furthermore, for easy understanding, it is assumed that an electrically neutral oxygen vacancy is formed.", "The calculation results of the formation energy for each case are as shown in FIG.", "40.The results indicate that formation of oxygen vacancies and oxygen deintercalation easily occur when a is smaller than 2.In other words, it is conceivable that oxygen vacancies are formed when Li atoms in Li2MnO3 are reduced, leading to easy oxygen deintercalation.", "The above two calculations suggest that Li deintercalation from Li2MnO3 causes charge compensation from the p orbital of oxygen and a bond with a metal element is weakened, leading to oxygen deintercalation.", "The results obtained in this example suggest that oxygen deintercalation is likely to occur in the lithium-manganese composite oxides described in Example 1.In the case where the lithium-manganese composite oxides whose surfaces are not covered with graphene is used as an active material, the cycle characteristics deteriorate as shown in.", "FIGS.", "30A and 30B and FIG.", "32.This is probably because of oxygen deintercalation from the lithium-manganese composite oxides.", "In contrast, when the lithium-manganese composite oxides whose surfaces are covered with graphene are used as an active material, the cycle characteristics are improved as shown in FIGS.", "30A and 30B and FIG.", "32.This is probably because graphene prevents oxygen deintercalation from the lithium-manganese composite oxides.", "EXAMPLE 6 In this example, examination results of crystal orientation of a cleavage plane of the active material of one embodiment of the present invention will be described.", "First, an active material used in this example is described.", "The active material used in this example was formed under the same conditions as the sample F in Example 4.An electrode was formed using the active material under the same conditions as the electrode H in Example 4 and then, one active material particle was observed by cross-sectional TEM.", "FIG.", "41 shows a cross section of one active material particle (crystal grain) contained in the electrode.", "FIG.", "42A is a high-resolution TEM image of one portion in FIG.", "41, and FIG.", "42B shows a Fourier transform diffraction pattern and fitting results on a crystal database.", "Note that layer structures in the images in FIG.", "41 and FIG.", "42A are parallel to each other.", "A diffraction pattern in.", "FIG.", "42B indicates that the lattice spacing (d value) of a diffraction spot A is 0.479 nm, the d value of a diffraction spot B is 0.368 nm, and the d value of a diffraction spot C is 0.399 nm.", "The diffraction pattern also indicates that ∠AOB is 60.3°, ∠AOC is 107.7°, and ∠BOC is 47.4°.", "Note that according to the database, the d value of a (001) plane of Li2MnO3 (84-1634) obtained by electron beam incident in a [110] direction is 0.474 nm, the d value of a (-111) plane is 0.367 nm, the d value of a (-110) plane is 0.408 nm, ∠AOB is 59.2°, ∠AOC is 107.0°, and ∠BOC is 47.8°.", "The comparison of the values obtained by the result in.", "FIG.", "42B and the values in the database indicates that the crystal structure agrees with that of Li2MnO3 (JCPDS84-1634).", "FIG.", "41 shows that the crystal is cleaved along a plane at a right end of the crystal grain.", "The directions of the spots in FIG.", "42B indicate that the cleavage plane at the right end in FIG.", "41 is a (001) plane.", "The (001) plane is equivalent to a (00-1) plane because of the crystal symmetry of Li2MnO3.Accordingly, the active material of one embodiment of the present invention is probably cleaved along the (001) plane or the (00-1) plane.", "FIG.", "43 shows a cross section of different active material particle (crystal grain) contained in the electrode.", "FIG.", "44A is a high-resolution TEM image of one portion in FIG.", "43, and FIG.", "44B shows a Fourier transform diffraction pattern and fitting results on a crystal database.", "Note that layer structures in the images in FIG.", "43 and FIG.", "44A are parallel to each other.", "A diffraction pattern in FIG.", "44B indicates that the lattice spacing (d value) of a diffraction spot A is 0.478 nm, the d value of a diffraction spot B is 0.319 nm, and the d value of a diffraction spot C is 0.430 nm.", "The diffraction pattern also indicates that ∠AOB is 48.7°, ∠AOC is 89.9°, and ∠BOC is 41.2°.", "Note that according to the database, the d value of a (001) plane of Li2MnO3 (84-1634) obtained by electron beam incident in a [100] direction is 0.474 nm, the d value of a (021) plane is 0.317 nm, the d value of a (020) plane is 0.426 nm, ∠AOB is 48.0°, ∠AOC is 90.0°, and ∠BOC is 42.0°.", "The comparison of the values obtained by the result in FIG.", "44B and the values in the database indicates that the crystal structure agrees with that of Li2MnO3 (JCPDS84-1634).", "FIG.", "43 shows that the crystal is cleaved along a plane at a lower end and at a right end of the crystal grain.", "The directions of the spots in FIG.", "44B indicate that the cleavage plane at the lower end in FIG.", "43 is a (0-10) plane and the cleavage plane at the right end is a (0-2-1) plane.", "The (0-10) plane is equivalent to a (010) plane and the (0-2-1) plane is equivalent to a (021) plane, a (02-1) plane, and a (0-21) plane because of the crystal symmetry of Li2MnO3.Accordingly, the active material of one embodiment of the present invention is probably cleaved along the (010) plane, the (0-10) plane, the (021) plane, the (02-1) plane, the (0-21) plane, or the (0-2-1) plane.", "EXAMPLE 7 In this example, measurement results of the rate characteristics and temperature characteristics of a cell J and a comparative cell K will be described.", "The cell J included an electrode J formed using the sample F in Example 4, and the comparative cell K includes a comparative electrode K formed using LiCoO2.Table 5 shows components of the electrodes and the half cells used in this example.", "TABLE 5 Active Conductive Cell Electrode material additive Binder Ratio [wt %] Half Cell J Electrode J Sample F AB PVdF Sample F:AB:PVdF = cell 90:5:5 Comparative Comparative LiCoO2 AB PVdF LiCoO2:AB:PVdF = cell K electrode K 90:5:5 The electrode J used in this example was formed under conditions similar to those of the electrode H formed in Example 4.The comparative electrode K was formed under the same conditions as the comparative electrode A described in Example 3 except that the sample A in the comparative electrode A was changed to LiCoO2.The cell J was fabricated using the electrode J and the comparative cell K was fabricated using the comparative electrode K. The cell J and the comparative cell K were fabricated under conditions similar to those of the cell B described in Example 3.After that, the rate characteristics of the cell J and the comparative cell K were measured.", "The measurement was performed with a charge-discharge measuring instrument (produced by TOYO SYSTEM Co., LTD) at room temperature (25° C.).", "The cell J and the comparative cell K were charged at a constant current with a current density of approximately 30 mA/g with the upper voltage limit set to 4.8 V. The cell J was discharged with a current density of 30 mA/g, 150 mA/g, 300 mA/g, 750 mA/g, and 1500 mA/g.", "The comparative cell K was discharged with a current density of 30 mA/g, 157 mA/g, 315 mA/g, 786 mA/g, and 1570 mA/g.", "FIG.", "45 shows discharge capacity with respect to the current density.", "In FIG.", "45, a lateral axis represents current density during discharging and a longitudinal axis represents discharge capacity per positive electrode active material weight measured with each current density.", "A plot of the cell J is indicated by circles and a plot of the comparative cell K is indicated by triangles in FIG.", "45.The results show that the cell J has better characteristics than the comparative cell K. Then, the charge and discharge characteristics of the cell J and the comparative cell K depending on temperature were measured.", "The measurement was performed with a charge-discharge measuring instrument (produced by TOYO SYSTEM Co., LTD) in a constant temperature bath.", "The measurement temperatures of the cell J were set to 60° C., 45° C., 25° C., 0° C., −10° C., and −20° C. The measurement temperatures of the comparative cell K were set to 60° C., 25° C., 0° C., and −20° C. In the measurement, constant current charging was performed with a current density of 30 mA/g and then, discharging was performed with a current density of 30 mA/g.", "Note that the charging was performed at 25° C. FIG.", "46 shows the measurement results of the charge and discharge characteristics depending on temperature.", "In FIG.", "46, a lateral axis represents temperature (° C.) and a longitudinal axis represents capacity per positive electrode active material weight (mAh/g).", "A plot of the cell J is indicated by circles and a plot of the comparative cell K is indicated by triangles in FIG.", "46.The results show that the cell J has better characteristics than the comparative cell K. FIG.", "47 is a SEM photograph of the sample F. As shown in FIG.", "47, the lithium-manganese composite oxides covered with graphene are aggregated.", "The aggregated lithium-manganese composite oxides covered with graphene have a spherical shape.", "In the sample F described in this example, a surface of a lithium-manganese composite oxide having a cleavage plane was covered with graphene, and the lithium-manganese composite oxides covered with graphene were aggregated by spray dry treatment to be a secondary particle.", "In the active material, which includes the secondary particle, the lithium-manganese composite oxides were bound with graphene.", "This is probably the reason why the conductivity of the active material was increased, the resistance of the electrode J was reduced, and the rate characteristics and temperature characteristics of the cell J fabricated using the electrode J were improved.", "EXAMPLE 8 In this example, an effect of aging performed on the electrodes of one embodiment of the present invention will be described with reference to FIG.", "48.Table 6 shows components of positive electrodes used in this example.", "TABLE 6 Active Conductive Electrode material additive Binder Ratio [wt %] Postive Sample F AB PVdF Sample F:AB:PVdF = electrode L1 90:5:5 Postive Sample F AB PVdF Sample F:AB:PVdF = electrode L2 90:5:5 Postive Sample F AB PVdF Sample F:AB:PVdF = electrode L3 90:5:5 Postive Sample F AB PVdF Sample F:AB:PVdF = electrode L4 90:5:5 Postive Sample F AB PVdF Sample F:AB:PVdF = electrode L5 90:5:5 Postive Sample F AB PVdF Sample F:AB:PVdF = electrode L6 90:5:5 First, positive electrodes L1 to L6 were formed using the sample F in Example 4, under conditions similar to those of the electrode H. Next, negative electrodes M1 to M5 were formed under conditions similar to the conditions described in Example 4.Then, a half cell was fabricated using the positive electrode L1 and a counter electrode containing a lithium metal.", "The characteristics were measured with the use of a CR2032 coin-type secondary battery (with a diameter of 20 mm and a height of 3.2 mm).", "As a separator, polypropylene was used.", "An electrolytic solution was formed in such a manner that lithium hexafluorophosphate (LiPF6) was dissolved at a concentration of 1 mol/L in a mixed solution in which ethylene carbonate (EC) and diethyl carbonate (DEC) were mixed at a volume ratio of 1:1.A positive electrode can and a negative electrode can were formed of stainless steel (SUS).", "Note that half cells with similar structures were formed using the positive electrodes L2, L3, and L6.The positive electrodes L1 to L3 were subjected to aging.", "For the aging, charging and discharging with a current density of 30 mA/g were repeated three times with the upper charging voltage limit set to 4.8 V and the lower discharging voltage limit set to 2.0 V. Then, a half cell was fabricated using the negative electrode M1 and a counter electrode containing a lithium metal.", "The characteristics were measured with the use of a CR2032 coin-type secondary battery (with a diameter of 20 mm and a height of 3.2 mm).", "As a separator, polypropylene was used.", "An electrolytic solution was formed in such a manner that lithium hexafluorophosphate (LiPF6) was dissolved at a concentration of 1 mol/L in a mixed solution in which ethylene carbonate (EC) and diethyl carbonate (DEC) were mixed at a volume ratio of 1:1.A positive electrode can and a negative electrode can were formed of stainless steel (SUS).", "Note that a half cell with a similar structure was formed using the negative electrode M4.Then, CCCV (0.1 C, 0.01 V) discharging was performed on the negative electrodes M1, M3, and M4 and Li was intercalated until the current value at CV reached 0.01, and then Li was deintercalated during CC (0.1 C, 1 V) charging.", "In addition, CC (0.1 C) discharging was performed on the negative electrodes M1 and M4 and Li equivalent to a capacity per graphite weight of 50 mAh/g was intercalated.", "Then, the half cells including the positive electrodes L1 to L3 and the half cells including the negative electrodes M1 and M4 were disassembled and washed with DMC three times.", "A cell L1 (full cell) was fabricated using the positive electrode L1 and the negative electrode M1.A CR2032 coin-type secondary battery (with a diameter of 20 mm and a height of 3.2 mm) was fabricated.", "As a separator, polypropylene was used.", "An electrolytic solution was formed in such a manner that lithium hexafluorophosphate (LiPF6) was dissolved at a concentration of 1 mol/L in a mixed solution in which ethylene carbonate (EC) and diethyl carbonate (DEC) were mixed at a volume ratio of 1:1.A positive electrode can and a negative electrode can were formed of stainless steel (SUS).", "A cell L2 was fabricated using the positive electrode L2 and the negative electrode M2, a cell L3 was fabricated using the positive electrode L3 and the negative electrode M3, a cell L4 was fabricated using the positive electrode L4 and the negative electrode M4, and a cell L5 was fabricated using the positive electrode L5 and the negative electrode M5.Note that the cells L2 to L5 had the same structure as the cell L1 except for the positive electrode and the negative electrode.", "Table 7 shows components of the full cells and the half used in this example.", "TABLE 7 Cell Full cell Cell L1 Positive electrode L1 Negative electrode M1 a n re-do in Cell L2 Positive electrode L2 Negative electrode M2 (aging) (no pre-doping) Cell L3 Positive electrode L3 Negative electrode M3 (aging) (no pre-doping but 1st charge/discharge) Cell L4 Positive electrode L4 Negative electrode M4 (no aging) (pre-doping) Cell L5 Positive electrode L5 Negative electrode M5 (no aging) (no pre-doping) Half cell Cell L6 Positive electrode L6 — (no aging) indicates data missing or illegible when filed The cycle characteristics of the fabricated cells L1 to L6 were measured.", "In a cycle test, constant current charging was performed with a current density per active material weight of 30 mA/g until the voltage reached a termination voltage of 4.6 V. Constant current discharging was performed with a current density of 30 mA/g until the voltage reached a termination voltage of 2.0 V. The temperature during the charging and discharging was 25° C. In the cycle test, constant current charging and discharging were repeated.", "FIG.", "48 shows the charge-discharge cycle characteristics of the cells L1 to L6.In FIG.", "48, a longitudinal axis represents capacity [mAh/g] and a lateral axis represents the number of cycles [times].", "Here, capacity was normalized by the weight of the positive electrode active material.", "In FIG.", "48, a plot of the cell L1 is indicated by black circles, a plot of the cell L2 is indicated by open circles, a plot of the cell L3 is indicated by white squares, a plot of the cell L4 is indicated by white triangles, a plot of the cell L5 is indicated by crosses, and a plot of the cell L6 is indicated by stars.", "As shown in FIG.", "48, the cell L1 whose positive electrode was subjected to aging and whose negative electrode was μm-doped with lithium has favorable characteristics which are equivalent to those of the half cell including the cell L6.Furthermore, the cells L2 and L3 whose positive electrodes were subjected to aging and whose negative electrodes were not pre-doped with lithium also have favorable characteristics behind the cell L1.In addition, the initial capacities of the cells L4 and L5 whose positive electrodes were not subjected to aging are lower than those of the cells L1 to L3 whose positive electrodes were subjected to aging.", "Moreover, the capacities of the cells L4 and L5 are lower than those of the cells L1 to L3 even after some cycles.", "The results in FIG.", "48 show that aging performed on the electrode of one embodiment of the present invention improves cycle characteristics.", "EXAMPLE 9 In this example, results of aging performed on the electrode of one embodiment of the present invention under conditions different from those in Example 8 will be described with reference to FIG.", "50.Electrodes used in this example will be described.", "First, a positive electrode n was formed using the sample F in Example 4, under conditions similar to those of the electrode H. Furthermore, a negative electrode o was formed under conditions similar to the conditions of the negative electrode in Example 4.Then, a laminated cell including the positive electrode n and a negative electrode formed of a graphite electrode was fabricated and constant current driving was performed two cycles at 25° C. at a rate of 0.1 C until the charging voltage reached a termination voltage of 4.6 V or until the discharging voltage reached a termination voltage of 2.0 V. The positive electrode after the two cycles is a positive electrode N. After that, the laminated cell was unsealed to take out the positive electrode N. Next, a laminated cell including a positive electrode formed using LiFePO4 and the negative electrode o was fabricated and charged at 25° C. at a constant current at a rate of 0.01 C until the voltage reached a termination voltage of 3.2 V. After that, the laminated cell was unsealed for degassing and then sealed again.", "Subsequently, the laminated cell was charged at 25° C. at a constant current at a rate of 0.1 C until the voltage reached a termination voltage of 4.0 V and discharged at 0.2 C until the voltage reached a termination voltage of 2.0 V. Then, the laminated cell was discharged at 25° C. until the voltage reached a termination voltage of 2.0 V. Lastly, a positive electrode capacity of 40 mAh/g was charged at 25° C. at a constant current at a rate of 0.2 C. The negative electrode at this time in which Li equivalent to a positive electrode capacity of 40 mAh/g was intercalated was a negative electrode O.", "After that, the laminated cell was unsealed to take out the negative electrode O.", "A cell M (full cell) was fabricated using the positive electrode N and the negative electrode O.", "A laminated secondary battery was fabricated as the full cell.", "As a separator, polypropylene was used.", "An electrolytic solution was formed in such a manner that lithium hexafluorophosphate (LiPF6) was dissolved at a concentration of 1 mol/L in a mixed solution in which ethylene carbonate (EC), diethyl carbonate (DEC), and ethylmethyl carbonate (EMC) were mixed at a volume ratio of 3:6:1.Then, the cycle characteristics of the cell M were measured.", "In one cycle of a cycle test, charging until the voltage reached a termination voltage of 4.6 V and discharging until the voltage reached a termination voltage of 2.0 V were performed at 25° C. at a constant current at a rate of 0.2 C. FIG.", "50 shows the charge-discharge cycle characteristics of the cell M. In FIG.", "50, a longitudinal axis represents capacity retention rate (%) and a lateral axis represents the number of cycles (times).", "As shown in FIG.", "50, the capacity retention rate is approximately 80% even after 500 cycles, indicating that the cell M has favorable characteristics.", "EXAMPLE 10 In this example, measurement results of the charge and discharge characteristics of a cell fabricated using the electrode of one embodiment of the present invention will be described.", "An electrode used in this example will be described.", "First, a positive electrode P was formed as a positive electrode using the sample F in Example 4, under conditions similar to those of the electrode H. Note that in the positive electrode P, the compounding ratio of the sample F to AB and PVdF in the electrode binder composition was 85:5:10 (weight ratio).", "Next, a half cell was fabricated using the electrode P. For the cell, a coin cell was used.", "Lithium was used for a counter electrode of the half cell.", "An electrolytic solution was formed by dissolving LiPF6 as an electrolyte in a mixed solution containing EC and DEC, which are aprotic organic solvents, at a volume ratio of 1:1.As the separator, polypropylene (PP) was used.", "Then, aging was performed on the fabricated half cell at 25° C. Specifically, constant current charging was performed at a rate of 0.1 C (current density of 30 mA/g) with a capacity of 150 mAh/g and constant current discharging was performed at a rate of 0.1 C with the lower voltage limit set to 2 V in the first cycle, constant current charging was performed at a rate of 0.1 C with a capacity of 180 mAh/g and constant current discharging was performed at a rate of 0.1 C with the lower voltage limit set to 2 V in the second cycle, constant current charging was performed at a rate of 0.1 C with a capacity of 210 mAh/g and constant current discharging was performed at a rate of 0.1 C with the lower voltage limit set to 2 V in the third cycle, constant current charging was performed at a rate of 0.1 C with a capacity of 240 mAh/g and constant current discharging was performed at a rate of 0.1 C with the lower voltage limit set to 2 V in the fourth cycle, and constant current charging was performed at a rate of 0.1 C with a capacity of 270 mAh/g and constant current discharging was performed at a rate of 0.1 C with the lower voltage limit set to 2 V in the fifth cycle.", "The charge and discharge characteristics were measured at 25° C. after the above aging.", "Constant current charging was performed at a rate of 0.1 C with the upper voltage limit set to 4.8 V and constant current discharging was performed at a rate of 0.1 C with the lower voltage limit set to 2 V FIG.", "51 shows charge and discharge curves.", "In FIG.", "51, a longitudinal axis represents voltage (V) and a lateral axis represents capacity (mAh/g).", "The results show that a high discharge capacity higher than 300 mAh/g is achieved when the active material of one embodiment of the present invention.", "EXPLANATION OF REFERENCE 100: electrode, 101: current collector, 102: active material layer, 110: primary particle, 110a: particle, 110b: particle, 111: primary particle, 111a: particle, 111b: particle, 112: primary particle, 113a: particle, 120a: graphene, 120b: graphene, 121a: graphene, 122: graphene, 130a: graphene, 151: solid line, 152: solid line, 153; solid line, 300: storage battery, 301: positive electrode can, 302: negative electrode can, 303: gasket, 304: positive electrode, 305: positive electrode current collector, 306: positive electrode active material layer, 307: negative electrode, 308: negative electrode current collector, 309: negative electrode active material layer, 310: separator, 500: storage battery, 501: positive electrode current collector, 502: positive electrode active material layer, 503: positive electrode, 504: negative electrode current collector, 505: negative electrode active material layer, 506: negative electrode, 507: separator, 508: electrolyte solution, 509: exterior body, 510: the positive electrode Lead electrode, 511: negative electrode: lead electrode, 512: welding region, 513: bent portion, 514: sealing portion, 600: storage battery, 601; positive electrode cap, 602: battery can, 603: positive electrode terminal, 604: positive electrode, 605: separator, 606: negative electrode, 607: negative electrode terminal, 608: insulating plate, 609: insulating plate, 611; PTC element, 612: safety valve mechanism, 721: two-fluid nozzle, 722: heating means, 723: spray cylinder; 724: cyclone, 725: container, 900: circuit board, 910: label, 911: terminal, 912.: circuit, 913: storage battery, 914: antenna, 915; antenna, 916: layer, 917: layer, 918: antenna, 919: terminal, 920: display device, 921: sensor, 922: terminal, 951: terminal, 952: terminal, 980: storage battery, 981: film, 982: film, 990: storage battery, 991: exterior body, 992: exterior body, 993: wound body, 994: negative electrode, 995: positive electrode, 996: separator, 997: lead electrode, 998: lead electrode, 1700: curved surface, 1701: plane, 1702: curve, 1703: radius of curvature, 1704: center of curvature, 1800: center of curvature, 1801: film, 1802: radius of curvature, 1803: film, 1804: radius of curvature, 7100: portable display device, 7101; housing, 7102: display portion, 7103: operation button, 7104: power storage device, 7200: portable information terminal, 7201: housing, 7202: display portion, 7203: band, 7204; buckle, 7205: operation button, 7206: input-output terminal, 7207: icon, 7300: display device, 7304: display portion, 7400: mobile phone, 7401: housing, 7402: display portion, 7403: operation button, 7404: external connection port, 7405: speaker, 7406: microphone, 7407; power storage device, 7408: lead electrode, 7409: current collector, 8000: display device, 8001: housing, 8002: display portion, 8003: speaker portion, 8004: power storage device, 8021: charging device, 8022: cable, 8024: power storage device, 8100; lighting device, 8101: housing, 8102: light source, 8103: power storage device, 8104: ceiling, 8105: wall, 8106: floor, 8107: window, 8200: indoor unit, 8201: housing, 8202: air outlet, 8203: power storage device, 8204: outdoor unit, 8300: electric refrigerator-freezer, 8301: housing, 8302: refrigerator door, 8303: freezer door, 8304: power storage device, 8400: automobile, 8401: headlight.", "8500: automobile, 9600: tablet terminal, 9625: switch, 9626: switch, 9627: power source switch, 9628: operation switch, 9629: fastener, 9630: housing, 9630a: housing, 9630b; housing, 9631: display portion, 9631a: display portion, 9631b: display portion, 9632a: region, 9632b: region, 9633: solar cell, 9634: charge and discharge control circuit, 9635: power storage unit, 9636: DCDC converter, 9637: converter, 9638; operation key, 9639: button, and 9640: movable portion.", "This application is based on Japanese Patent Application serial no.", "2014-097946 filed with Japan Patent Office on May 9, 2014, Japanese Patent Application serial no.", "2014-105515 filed with Japan Patent Office on May 21, 2014, and Japanese Patent Application serial no.", "2014-219383 filed with Japan Patent Office on Oct. 28, 2014, the entire contents of which are hereby incorporated by reference." ] ]
Patent_15874123
[ [ "Unload Tee", "An unload tee has a tee body with a front side and a rear side.", "The tee body includes an extendable link pivotally connected to the front side of the tee body wherein the extendable link is slidable from a first position wherein the extendable link is shortened to a second position wherein the extendable link is lengthened.", "An arm is pivotally connected at an opposite end of the extendable link and a door is pivotally connected to an end of the arm unconnected to the shaft.", "The door is configured to cover an opening of the tee body, wherein an end of the door unconnected to the arm is pivotally connected proximate the rear side of the tee body." ], [ "1.A method of unloading a volume of materials through an unload tee, comprising the steps of: manipulating a handle of the unload tee with one action; and opening a door of the unload tee according the step of manipulating the handle.", "2.The method according to claim 1, further comprising the step of exerting the one action via an operator.", "3.The method according to claim 1, further comprising the step closing the door of the unload tee according another step of manipulating the handle.", "4.The method according to claim 1, further comprising the steps of: pivoting an arm connected to an extendable link relative to the extendable link via said step of manipulating the handle; pivoting the extendable link connected to the unload tee relative to the unload tee; pivoting the door connected to the arm relative to the arm; and wherein said step of opening the door further comprises pivoting the door connected to the unload tee relative to the unload tee.", "5.The method according to claim 4, further comprising the step of extending the extendable link in response to said steps of pivoting the arm and pivoting the door.", "6.The method according to claim 1, further comprising the steps of: wherein said step of manipulating the handle further comprises the handle connected to an arm, wherein the arm is pivotally connected to an extendable link, and wherein the arm is pivotally connected to the door at one end of the arm; transferring motion from the handle to the arm and the extendable link, wherein the extendable link is capable of shortening and lengthening and is pivotally connected to a front beam of the unload tee; pivoting the extendable link about the front beam; lengthening the extendable link; pivoting the arm about the extendable link for opening the door.", "7.The method according to claim 6, wherein the step of manipulating the handle enables the steps of: pivoting the extendable link about the front beam; lengthening the extendable link; pivoting the arm about the extendable link; and opening the door of the unload tee.", "8.The method according to claim 6, further comprising the steps of: opening a controllable valve connected to the unload tee; and allowing the volume of materials to flow past the arm to a desired destination for the volume of materials.", "9.The method according to claim 6, further comprising the step of securing a second arm to the tee body when the unload tee is in a closed position.", "10.The method according to claim 9, further comprising the steps of pivoting a barrel about the front beam and inverting the barrel beneath the front beam." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> BRIEF SUMMARY <EOH>An unload tee has a tee body with a front side and a rear side.", "The tee assembly includes an extendable link pivotally connected at one end to the tee body and at the other end to the handle, which also acts as part of the linkage.", "This extendable link allows for the compact storage of the linkage while in the ‘closed’ position and also allows the linkage to have the necessary span to allow the door to be completely out of the path of the falling material when the tee is in the ‘open’ position.", "The door is located on the very bottom of the tee body and is situated to cover an opening that extends from the very top through to the bottom, allowing for the passage of material through the tee.", "The door is pivotally connected to the ‘rear’ of the tee body and at the ‘front’ side it is pivotally connected to the handle, which as previously stated, is also connected to one end of the extendable link." ], [ "STATEMENTS REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT Not Applicable.", "NAMES OF THE PARTIES TO A JOINT RESEARCH AGREEMENT Not Applicable.", "REFERENCE TO A “SEQUENCE LISTING”, A TABLE, OR A COMPUTER PROGRAM Not Applicable.", "BACKGROUND Technical Field Exemplary embodiments disclosed herein relate to techniques for unload tees used in transporting materials.", "Unload tees are used in a variety of industries to transport and deliver bulk materials.", "Unload tees may be installed at the bottom of transportation vehicles (or other difficult to reach places) and further, conventional unload tees may be difficult to operate at certain angles or in certain situations.", "This may result in haphazard securing of the tee when delivery is complete, resulting in damage to the assembly and/or vehicle.", "Thus, there is a need for an improved unload tee that is secure, safe and allows for ease of operation.", "BRIEF SUMMARY An unload tee has a tee body with a front side and a rear side.", "The tee assembly includes an extendable link pivotally connected at one end to the tee body and at the other end to the handle, which also acts as part of the linkage.", "This extendable link allows for the compact storage of the linkage while in the ‘closed’ position and also allows the linkage to have the necessary span to allow the door to be completely out of the path of the falling material when the tee is in the ‘open’ position.", "The door is located on the very bottom of the tee body and is situated to cover an opening that extends from the very top through to the bottom, allowing for the passage of material through the tee.", "The door is pivotally connected to the ‘rear’ of the tee body and at the ‘front’ side it is pivotally connected to the handle, which as previously stated, is also connected to one end of the extendable link.", "BRIEF DESCRIPTION OF THE DRAWINGS The exemplary embodiments may be better understood, and numerous objects, features, and advantages made apparent to those skilled in the art by referencing the accompanying drawings.", "These drawings are used to illustrate only exemplary embodiments, and are not to be considered limiting of its scope, for the disclosure may admit to other equally effective exemplary embodiments.", "The figures are not necessarily to scale and certain features and certain views of the figures may be shown exaggerated in scale or in schematic in the interest of clarity and conciseness.", "FIG.", "1 depicts a perspective view of an exemplary embodiment of an unload tee in a fully open position.", "FIG.", "1A depicts a schematic view of an exemplary embodiment of a transportation vehicle or storage vessel, valve and unload tee with the unload tee in a fully open position delivering a volume of material.", "FIG.", "2 depicts a perspective view of an exemplary embodiment of an unload tee in a closed position.", "FIG.", "3 depicts a side view of an exemplary embodiment of an unload tee in a closed position.", "FIG.", "4 depicts a side view of an exemplary embodiment of an unload tee in a partially open position following the position of FIG.", "3 when opening.", "FIG.", "5 depicts a side view of an exemplary embodiment of an unload tee in another partially open position following the position of FIG.", "4 when opening.", "FIG.", "6 depicts a side view of an exemplary embodiment of an unload tee in a fully open position following the position of FIG.", "5 when opening.", "DESCRIPTION OF EXEMPLARY EMBODIMENT(S) The description that follows includes exemplary apparatus, methods, techniques, and instruction sequences that embody techniques of the inventive subject matter.", "However, it is understood that the described exemplary embodiments may be practiced without these specific details.", "FIG.", "1 depicts a perspective view of an exemplary embodiment of an unload tee 10 in a fully open position.", "FIG.", "1A depicts a schematic view of an exemplary embodiment of the unload tee 10 in the fully open position delivering a volume of material 70 below a transportation vehicle 60 and valve 50.The unload tee 10 has a tee body 12 which defines a bore 14 that travels through the tee body 12.As known to one having ordinary skill in the art, at one end of the bore 14 is a flange 16 configured for attaching or mounting to a controllable valve 50 (such as, for example, a butterfly valve) sandwiched between the flange 16 and a transportation vehicle/storage vessel 60 (or other pipe or conduit system to which the unload tee 10 is connected).", "At the opposite end of the bore 14 from flange 16 (and forming part of the bore 14) is an opening 13, which is covered by the tee door 24 when the unload tee 10 is in a closed position (see FIG.", "2).", "Further, the tee body 12 may have coupling ends 18 at an axis perpendicular to the bore 14.The coupling ends 18 as known to one having ordinary skill in the art may run along the vehicle/storage vessel 60 and/or may connect the unload tee 10 for establishing flow along the vehicle 60 to pipes, hoses, tees or other fittings as part of the materials transport or pipe system.", "The unload tee 10 may further be characterized by having a front or operating side 30 and a back or rear side 32.The operating or front side 30 may be the face, plane or side of the unload tee 10 that the operator of the transport or pipe system substantially interacts with to manipulate or change the position of the unload tee 10 and/or the control valve.", "The unload tee 10 further includes a plurality of beams 11 which extend outwards from the tee body 12 and are coupled to a door assembly 20.The beams 11 may further be characterized into front beams 11a on the front side 30 and rear beams 11b on the rear side 32.Both front and rear beams 11a, 11b may both be located towards the lower end or underside 34 of the body 12 (or towards the opening 13 for the door 24).", "Additionally, the unload tee 10 may optionally include one or more projection(s) or keeper(s) 17, one of which may define a fastener port 19 for use with securing and/or latching the door assembly 20 into the closed position.", "Other means for safely securing the door assembly 20 to the tee body 12 in the closed position may be implemented as known to one having ordinary skill in the art.", "The door assembly 20 of the unload tee 10 in an exemplary embodiment includes the door 24, at least one arm 22 (two shown), a handle or lever 26, and at least one extendable links 40 (two shown).", "In one embodiment, assuming two extendable links 40, the two extendable links 40 are made of two barrels 21, and two shafts 23.Each barrel 21 is pivotally and/or rotatably coupled to one of the front beams 11a of the tee body 12.The barrels 21 should be configured to have a range of rotation such that the barrels 21 may be able to rotate, invert or reverse beneath the underside 34 of the tee body 12.At the opposite end of each of the barrels 21, a shaft 23 is inserted into the barrel 21 and allowed to slidably move into and out of the barrel 21.In one exemplary embodiment the extendable link 40 (or barrel 21 and shaft 23) are telescoping parts.", "In another exemplary embodiment the extendable link 40 or barrel 21 may be a pneumatic or hydraulic cylinder with the shaft 23, for example, functioning as a piston, or may be spring loaded.", "The extendable link may function to urge, bias or maintain the door 24 in the closed position (FIG.", "3) and/or the open position (FIG.", "6).", "The opposite end of each shaft 23 is inserted into an open bracket 25 defined on one end of an arm 22.The connection between each shaft 23 and each bracket 25 should allow the shaft 23 to pivot, swivel or rotate within the bracket 25 about the connection point.", "One of the arms 22 may be connected to, and may be unitary or integral with, a handle 26.As depicted in FIG.", "1, the handle 26 is connected (in a unitary manner and preferably aligned) to the arm 22a.", "The handle 26 should be configured to be accessible by the operator of the system from the operating or front side 30.In the closed position, the handle 26 may extend above the flange 16 for ease of access by the operator of the transportation system.", "The second arm 22b in FIG.", "1 defines a means for fastening or a fastener port 29, for fastening to the tee body 12.In alternative exemplary embodiments, the handle 26 may be connected to, contiguous with or unitary with the arm 22b, and the fastener port 29 may be defined instead on the arm 22a.", "Although one handle 26 is currently preferred, in certain exemplary embodiments greater than one handle 26 may be implemented (e.g., such as connected to arm 22b).", "The ends of the arms 22 not connected with the shaft 23 are pivotally coupled with the door 24.Further, when the unload tee 10 is in the fully open position (see FIGS.", "1, 1A and 6) the arms 22 may define a void 27 (defined between the first arm 22a and the second arm 22b) such that the arms 22 (or other parts of the door assembly 20) allow or do not inhibit the flow or delivery of a volume of materials 70 from the opening 13.When in the unload tee 10 is in the closed position, as is depicted in FIGS.", "2 and 3, a fastener 28 may be used to secure the door assembly 20 and the tee body 12.The fastener 28, as depicted, is a clevis pin 28a inserted through fastener port 19 on the projection 17 of the body 12 and fastener port 29 on the arm 22b, but other safe means of fastening may be implemented as is known in the art.", "The fastener 28 should be easily removed and reusable to allow for ease and efficiency of operation.", "In an exemplary embodiment, the fastener 28 and fastener ports 19, 29 may be located on the operating or front side 30 of the unload tee 10.FIGS.", "3-6 depict a side view of the unload tee 10 as the unload tee 10 moves between a fully closed position (in FIG.", "3), to partially open positions (in FIGS.", "4-5), and then subsequently to a fully open position (in FIG.", "6).", "The progressive opening of the unload tee 10 from FIGS.", "3 to 4, from FIGS.", "4 to 5, and from FIGS.", "5 to 6 (or also from FIGS.", "3 to 6) may all occur with one motion or action from the operator (normally a human) exerting force onto the handle 26.The closing of the unload tee 10, may also likewise occur with a singular motion or action from the operator onto the handle 26.Preferably, the foregoing one opening action and singular closing action are exclusive of any additional (external) motive force or action for opening and/or closing of the door 24.As depicted in the closed tee 10 position seen in FIGS.", "2 and 3, the handle 26 is aligned with the bore 14 of the tee body 12 and raised above the flange 16 in the closed position.", "The extendable link 40 is in a first position wherein the extendable link 40 is shortened as shown in FIG.", "2, FIG.", "3 and/or FIG.", "4.Further, the fastener 28 may be engaged with the fastener ports 19 and 29 to secure and retain the door assembly 20 in the desired closed position.", "When the operator needs to deliver the desired bulk materials, goods or product through the unload tee 10 to the desired location (or otherwise needs to manipulate unload tee 10 into an open position), the fastener 28, if implemented, is first removed or disengaged from the fastener ports 19 and 29.Then the operator manipulates or pulls the handle 26 to move outwards and away from its upright position adjacent to the tee body 12 to a partially open position of the unload tee 10 as depicted in FIG.", "4.When the handle 26 is thus manipulated, the barrels 21 pivot about the front beams 11a to extend outwards and away from the tee body 12.The extendable link 40 may remain in the first position (where the extendable link 40 remains shortened) in FIG.", "4.The handle 26 transfers the movement from the operator to the arms 22 as well, which pivot about their connection to the door 24 to point towards the front side 30, and may cause the door 24 to move slightly ajar and reveal the opening 13 as the door pivots about the rear beam(s) 11b.", "To further open the unload tee 10, the handle 26 is further manipulated or pushed downwards into another partially open position as seen in FIG.", "5 following the position of FIG.", "4 when opening.", "The barrels 21 shown at this position have pivoted to point downwards and the shaft 23 may adjust in or out of the barrels 21 to compensate for any necessary distance/tension as the arms 22 move.", "Thus, the extendable link 40 may slidably lengthen in the second position (as depicted in FIGS.", "1, 1A, and/or 5-6) relative to the first position of the extendable link 40 (which is depicted in FIGS.", "2, 3 and/or 4, wherein the extendable link 40 is shortened).", "The door 24 also pivots open about the rear beams 11b, further revealing opening 13.FIG.", "6 depicts a side view of an exemplary embodiment of the unload tee 10 in a fully open position.", "To move the unload tee 10 to the fully open position in FIG.", "6 from the partially open position in FIG.", "5, the handle 26 is further manipulated to push the door 24 further open and away from the opening 13.In order to transition from the partially open position in FIG.", "5 to the fully open position in FIG.", "6, the barrels 21 pivot or reverse about the front beams 11a to point backwards, or reverse, towards the door 24 upon transferred motion from the handle 26.Each of the arms 22 also pivot about the bracket connection 25 with the shafts 23 such that the handle 26 is angled upwards towards the operator for single sided operation from the front side 30 when the operator desires to close the unload tee 10.In the fully open position of the unload tee 10 in FIGS.", "1 and 6, the door 24 and the arms 22 (and all other parts of the door assembly 20) do not block or inhibit a direct materials flow from the opening 13.Thus the unload tee 10 may be manipulated into an open position with one action/exertion from the operator onto the handle 26, as the motion from the operator onto handle 26 may be transferred to the various components and enables moving or pivoting points, and/or joints of the unload tee 10.At this point, the operator may decide to open the control valve connected to the flange 16, or manipulate a valve at another point in the pipe system, to allow a flow of materials through the opening 13 to the desired location.", "When satisfied with the delivery of materials, the operator may shut off the valve and reverse the steps of opening the unload tee 10 to fully close the tee 10.Preferably, the length of the door 24 is less than the clearance between the underside/lower end of tee body 34 and the surface of the ground.", "To close the unload tee 10 from the fully open position as shown in FIG.", "6, the handle 26 is pulled upward and forward or away from the tee body 12.The barrels 21 and shafts 23 pivot away and downwards from the body 12 as depicted FIG.", "5.Continued pulling of the handle 26 towards the operator or the front/operating side 30 will extend the barrels 21 to point outward from the body 12 and towards the front side of operation 30, as seen in FIG.", "4.The shafts 23 may progressively contract, insert, or slide inwards or shorten into the barrels 21 when the unload tee 10 is moved more towards a fully closed position.", "Finally, the handle 26 may be lifted above the flange 16, the motion of which causes the barrels 21 to flip or fold upward and over the front beams 11a and closes the tee door 24 against the opening 13.Thus the unload tee 10 may be manipulated into a closed position with one motion or action from the operator onto the handle 26, as the motion from the operator onto handle 26 may be transferred to the various components and enables moving or pivoting points, and/or joints of the unload tee 10.The unload tee 10 may now be secured into the fully closed position by engaging the optional fastener 28 with fastener ports 19, 29 on the body 12 and arms 29 respectively.", "All pivots/pivotables shown and/or described herein in an exemplary embodiment may be made from a hinge with linkage (as shown) or in any other manner known to one of ordinary skill in the art.", "While the exemplary embodiments are described with reference to various implementations and exploitations, it will be understood that these exemplary embodiments are illustrative and that the scope of the inventive subject matter is not limited to them.", "Many variations, modifications, additions and improvements are possible.", "For example, while the implementations and techniques used herein are discussed primarily in relation to the bulk handling transportation industries, alternative exemplary embodiments of the unload tee 10 may be applied to alternate industries, such as, by way of example only, petrochemical, irrigation, food and beverage industries and the like.", "Plural instances may be provided for components, operations or structures described herein as a single instance.", "In general, structures and functionality presented as separate components in the exemplary configurations may be implemented as a combined structure or component.", "Similarly, structures and functionality presented as a single component may be implemented as separate components.", "These and other variations, modifications, additions, and improvements may fall within the scope of the inventive subject matter." ] ]
Patent_15874129
[ [ "METHOD AND APPARATUS TO GENERATE HAPTIC FEEDBACK FROM VIDEO CONTENT ANALYSIS", "A system includes an image capture device configured to capture images, and a processor programmed with one or more computer program modules.", "When executed, the one or more computer program modules are configured to receive the images captured by the image capture device, generate a control signal for a haptic output device as the images are received, synchronize the images and the control signal, and output a video with the synchronized images and the control signal." ], [ "1.A method of generating haptics for a video, comprising: tracking motion of an object in the video; outputting sensor information based on the motion of the object; generating a control signal based on the sensor information; and providing haptic feedback based on the control signal, the providing of the haptic feedback occurring in synchronization with the motion of the object in the video.", "2.The method of claim 1, further comprising: obtaining images of the object in the video using an image capture device, wherein the tracking of the motion of the object includes using a sensor attached to the image capture device, and wherein the generating of the control signal is based on the images and the sensor information.", "3.The method of claim 2, wherein the sensor is an inertial measurement unit sensor, and the sensor information includes an inertial data estimation.", "4.The method of claim 1, further comprising: obtaining images of the object in the video using an image capture device, wherein the image capture device moves while obtaining the images, wherein the tracking of the motion of the object includes using a sensor attached to the image capture device or the object, and wherein the generating of the control signal is based on the images and the sensor information.", "5.The method of claim 1, wherein the providing of the haptic feedback includes rendering a first haptic effect using a haptic output device on a first peripheral device.", "6.The method of claim 5, wherein the providing of the haptic feedback further includes rendering a second haptic effect using a haptic output device on a second peripheral device, the second peripheral device being different than the first peripheral device.", "7.A system, comprising: a sensor tracking motion of an object in a video and outputting sensor information based on the motion of the object; a computing device having a processor programmed with a computer program module, wherein when executed, the computer program module is configured to generating a control signal based on the sensor information; and a first haptic output device configured to provide haptic feedback based on the control signal, wherein the haptic feedback is provided in synchronization with the motion of the object in the video.", "8.The system of claim 7, further comprising: an image capture device obtaining images of the object in the video, wherein the sensor is attached to the image capture device, and wherein the control signal is generated based on the images and the sensor information.", "9.The system of claim 8, wherein the sensor is an inertial measurement unit sensor, and the sensor information includes an inertial data estimation.", "10.The system of claim 7, further comprising: an image capture device obtaining images of the object in the video, wherein the image capture device is configured to move while obtaining the images, wherein the sensor attached to the image capture device or the object, and wherein the control signal is generated based on the images and the sensor information.", "11.The system of claim 7, further comprising: a first peripheral device including the first haptic output device, wherein the first haptic output device is configured to render a first haptic effect.", "12.The system of claim 11, further comprising: a second peripheral device including a second haptic output device, wherein the second haptic output device is configured to render a second haptic effect, the second peripheral device being different than the first peripheral device.", "13.The system of claim 7 being a video gaming system.", "14.A non-transitory computer readable medium having instructions stored thereon that, when executed by a processor, cause the processor to perform operations comprising: tracking motion of an object in a video; outputting sensor information based on the motion of the object; generating a control signal based on the sensor information; and providing haptic feedback based on the control signal, the providing of the haptic feedback occurring in synchronization with the motion of the object in the video.", "15.The non-transitory computer readable medium of claim 14, wherein the instructions cause the processor to perform the operations comprising: obtaining images of the object in the video using an image capture device, wherein the tracking of the motion of the object includes using a sensor attached to the image capture device, and wherein the generating of the control signal is based on the images and the sensor information.", "16.The non-transitory computer readable medium of claim 15, wherein the sensor is an inertial measurement unit sensor, and the sensor information includes an inertial data estimation.", "17.The non-transitory computer readable medium of claim 14, wherein the instructions cause the processor to perform the operations comprising: obtaining images of the object in the video using an image capture device, wherein the image capture device moves while obtaining the images, wherein the tracking of the motion of the object includes using a sensor attached to the image capture device or the object, and wherein the generating of the control signal is based on the images and the sensor information.", "18.The non-transitory computer readable medium of claim 14, wherein the providing of the haptic feedback includes rendering a first haptic effect using a haptic output device on a first peripheral device.", "19.The non-transitory computer readable medium of claim 18, wherein the providing of the haptic feedback further includes rendering a second haptic effect using a haptic output device on a second peripheral device, the second peripheral device being different than the first peripheral device." ], [ "<SOH> BACKGROUND <EOH>Conventional multimedia content such as video may be enhanced with haptic feedback.", "However, such enhancements typically require embedding information that encodes the haptic feedback directly into the video.", "Thus, these techniques are unable to provide real-time haptic feedback on pre-existing video that has not already been annotated with the information that encodes the haptic feedback.", "Furthermore, conventional media playback systems do not leverage sensor information that indicates a motion of an object that appears in a scene in the video to generate haptic feedback.", "Additionally, estimating an acceleration of an object based on video information may be inaccurate when the object is travelling at high speeds due to blur and other artifacts, while estimating an acceleration of the object using information from a sensor attached to the object may be inaccurate at low speeds." ], [ "<SOH> SUMMARY <EOH>The disclosure relates to systems and methods of generating haptic feedback based on video content analysis, sensor information, from one or more sensors, that includes one or more measurements of motion of one or more objects such as a person appearing on a video, and/or sensor information that includes one or more measurements of motion of one or more image capture devices.", "Generally speaking, the system may include a computing device having one or more processors programmed to perform the video content analysis and/or use the sensor information to cause a haptic feedback to be generated, thereby enhancing the user experience.", "The haptic feedback may vary based on an estimated acceleration of an object of a scene of the video, wherein the estimated acceleration is based on the image processing.", "The estimated acceleration may be made more accurate at high speeds using the sensor information and an estimated acceleration based on the sensor information may be made more accurate at lower speeds based on the image processing.", "In some implementations, the video content analysis may include image processing of one or more frames of the video.", "The computing device may identify one or more events based on the image processing and cause a haptic feedback based on the one or more events.", "The events may include, for example, movement of an image capture device, an appearance of an object, an appearance of a body part, an explosion, a moving object, a particular recognizable image feature, a facial expression, a gesture, a scene theme, and/or other events that may be identified based on the image processing.", "The computing device may generate a control signal that causes the haptic feedback and communicate the control signal to one or more haptic output devices that output the haptic feedback.", "The haptic output devices may be configured in various ways depending on particular uses and implementations of the computing device.", "For instance, haptic output devices may be integrated with the computing device (e.g., integrated within a common housing), a user interface device, a wearable device, a chair (e.g., in a movie theatre setting where the computing device performs image processing on a movie to provide immersive haptic feedback while watching the movie), and/or other configuration depending on particular implementations.", "Because the haptic feedback may be generated based on image processing, the computing device facilitates real-time haptic feedback without upstream embedding or provisioning of information that encodes haptic feedback into multimedia files or multimedia streams.", "Thus, the computing device may enhance video (and/or other multimedia content for which image processing may be performed) with haptic feedback even though the video has not been provided in association with or otherwise have embedded within information that causes the haptic feedback.", "In some implementations, the computing device may use sensor information that includes one or more measurements of motion related to multimedia content such as a video and generate the control signal that causes the haptic feedback.", "For example, at the time of capturing the video, one or more sensors may be coupled to an image capture device (e.g., a video camera) and/or an object being tracked (e.g., an object that appears on the video) such that the sensors measure a motion of the image capture device and/or the object and output sensor information that includes the measurements.", "In this manner, the motion of the object and/or the image capture device may be measured in order to provide sensor information used to provide haptic feedback.", "The captured video and/or sensor information may be streamed in real-time and/or stored for later provision to the computing device for playback.", "The computing device may obtain the sensor information and generate the control signal responsive to the sensor information.", "For example, the sensor information may indicate that the image capture device is in motion during a particular scene of a video.", "The computing device may generate a control signal responsive to the motion of the image capture device while capturing the particular scene, as determined based on the sensor information.", "Likewise, the sensor information may indicate that an object that appears on a scene of the video is in motion.", "The computing device may generate a control signal responsive to the motion of the object, as determined based on the sensor information.", "In some implementations, the computing device may generate a control signal that causes a haptic feedback based on a combination of motion of the image capture device and the object being tracked.", "In some implementations, the computing device may generate a first estimate of the speed, acceleration, and/or angular velocity of the object based on image processing and a second estimate of the speed, acceleration, and/or angular velocity of the object based on the sensor information.", "The computing device may generate a fused estimate of the speed, acceleration, and/or angular velocity of the object based on the first estimate and the second estimate.", "Using the fused estimate, the computing device may generate the control signal.", "In some implementations, the computing device may use the first estimate (based on the image processing) alone to generate the control signal.", "Whichever ones of the foregoing implementations of using motion information related to the video to generate the control signal is used, the computing device may enhance the video experience by causing haptic feedback to be provided when on-scene objects and/or image capture devices that capture scenes are in motion.", "For example, when the computing device determines that an object accelerates during a scene, the computing device may provide a control signal that causes haptic feedback that increases in intensity.", "In some implementations, the computing device may use image processing of the video alone to generate the control signal that causes the haptic feedback.", "In other implementations, the computing device may use sensor information alone to generate the control signal that causes the haptic feedback.", "In still other implementations, the computing device may use image processing in combination with the sensor information to generate the control signal that causes the haptic feedback.", "These and other features, and characteristics of the present technology, as well as the methods of operation and functions of the related elements of structure and the combination of parts and economies of manufacture, will become more apparent upon consideration of the following description and the appended claims with reference to the accompanying drawings, all of which form a part of this specification, wherein like reference numerals designate corresponding parts in the various figures.", "It is to be expressly understood, however, that the drawings are for the purpose of illustration and description only and are not intended as a definition of the limits of the invention.", "As used in the specification and in the claims, the singular form of “a”, “an”, and “the” include plural referents unless the context clearly dictates otherwise." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/719,491, filed on May 22, 2015, which claims the benefit of priority from U.S. patent application Ser.", "No.", "13/843,092, filed Mar.", "15, 2013, now U.S. Pat.", "No.", "9,064,385, issued Jun.", "23, 2015, the disclosures of which are hereby incorporated by reference.", "FIELD The disclosure relates to systems and methods of generating haptic feedback based on video content analysis, sensor information, from one or more sensors, that includes one or more measurements of motion of one or more objects appearing on a video, and/or sensor information that includes one or more measurements of motion of one or more image capture devices.", "BACKGROUND Conventional multimedia content such as video may be enhanced with haptic feedback.", "However, such enhancements typically require embedding information that encodes the haptic feedback directly into the video.", "Thus, these techniques are unable to provide real-time haptic feedback on pre-existing video that has not already been annotated with the information that encodes the haptic feedback.", "Furthermore, conventional media playback systems do not leverage sensor information that indicates a motion of an object that appears in a scene in the video to generate haptic feedback.", "Additionally, estimating an acceleration of an object based on video information may be inaccurate when the object is travelling at high speeds due to blur and other artifacts, while estimating an acceleration of the object using information from a sensor attached to the object may be inaccurate at low speeds.", "SUMMARY The disclosure relates to systems and methods of generating haptic feedback based on video content analysis, sensor information, from one or more sensors, that includes one or more measurements of motion of one or more objects such as a person appearing on a video, and/or sensor information that includes one or more measurements of motion of one or more image capture devices.", "Generally speaking, the system may include a computing device having one or more processors programmed to perform the video content analysis and/or use the sensor information to cause a haptic feedback to be generated, thereby enhancing the user experience.", "The haptic feedback may vary based on an estimated acceleration of an object of a scene of the video, wherein the estimated acceleration is based on the image processing.", "The estimated acceleration may be made more accurate at high speeds using the sensor information and an estimated acceleration based on the sensor information may be made more accurate at lower speeds based on the image processing.", "In some implementations, the video content analysis may include image processing of one or more frames of the video.", "The computing device may identify one or more events based on the image processing and cause a haptic feedback based on the one or more events.", "The events may include, for example, movement of an image capture device, an appearance of an object, an appearance of a body part, an explosion, a moving object, a particular recognizable image feature, a facial expression, a gesture, a scene theme, and/or other events that may be identified based on the image processing.", "The computing device may generate a control signal that causes the haptic feedback and communicate the control signal to one or more haptic output devices that output the haptic feedback.", "The haptic output devices may be configured in various ways depending on particular uses and implementations of the computing device.", "For instance, haptic output devices may be integrated with the computing device (e.g., integrated within a common housing), a user interface device, a wearable device, a chair (e.g., in a movie theatre setting where the computing device performs image processing on a movie to provide immersive haptic feedback while watching the movie), and/or other configuration depending on particular implementations.", "Because the haptic feedback may be generated based on image processing, the computing device facilitates real-time haptic feedback without upstream embedding or provisioning of information that encodes haptic feedback into multimedia files or multimedia streams.", "Thus, the computing device may enhance video (and/or other multimedia content for which image processing may be performed) with haptic feedback even though the video has not been provided in association with or otherwise have embedded within information that causes the haptic feedback.", "In some implementations, the computing device may use sensor information that includes one or more measurements of motion related to multimedia content such as a video and generate the control signal that causes the haptic feedback.", "For example, at the time of capturing the video, one or more sensors may be coupled to an image capture device (e.g., a video camera) and/or an object being tracked (e.g., an object that appears on the video) such that the sensors measure a motion of the image capture device and/or the object and output sensor information that includes the measurements.", "In this manner, the motion of the object and/or the image capture device may be measured in order to provide sensor information used to provide haptic feedback.", "The captured video and/or sensor information may be streamed in real-time and/or stored for later provision to the computing device for playback.", "The computing device may obtain the sensor information and generate the control signal responsive to the sensor information.", "For example, the sensor information may indicate that the image capture device is in motion during a particular scene of a video.", "The computing device may generate a control signal responsive to the motion of the image capture device while capturing the particular scene, as determined based on the sensor information.", "Likewise, the sensor information may indicate that an object that appears on a scene of the video is in motion.", "The computing device may generate a control signal responsive to the motion of the object, as determined based on the sensor information.", "In some implementations, the computing device may generate a control signal that causes a haptic feedback based on a combination of motion of the image capture device and the object being tracked.", "In some implementations, the computing device may generate a first estimate of the speed, acceleration, and/or angular velocity of the object based on image processing and a second estimate of the speed, acceleration, and/or angular velocity of the object based on the sensor information.", "The computing device may generate a fused estimate of the speed, acceleration, and/or angular velocity of the object based on the first estimate and the second estimate.", "Using the fused estimate, the computing device may generate the control signal.", "In some implementations, the computing device may use the first estimate (based on the image processing) alone to generate the control signal.", "Whichever ones of the foregoing implementations of using motion information related to the video to generate the control signal is used, the computing device may enhance the video experience by causing haptic feedback to be provided when on-scene objects and/or image capture devices that capture scenes are in motion.", "For example, when the computing device determines that an object accelerates during a scene, the computing device may provide a control signal that causes haptic feedback that increases in intensity.", "In some implementations, the computing device may use image processing of the video alone to generate the control signal that causes the haptic feedback.", "In other implementations, the computing device may use sensor information alone to generate the control signal that causes the haptic feedback.", "In still other implementations, the computing device may use image processing in combination with the sensor information to generate the control signal that causes the haptic feedback.", "These and other features, and characteristics of the present technology, as well as the methods of operation and functions of the related elements of structure and the combination of parts and economies of manufacture, will become more apparent upon consideration of the following description and the appended claims with reference to the accompanying drawings, all of which form a part of this specification, wherein like reference numerals designate corresponding parts in the various figures.", "It is to be expressly understood, however, that the drawings are for the purpose of illustration and description only and are not intended as a definition of the limits of the invention.", "As used in the specification and in the claims, the singular form of “a”, “an”, and “the” include plural referents unless the context clearly dictates otherwise.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a system configured to generate haptic feedback based on video content analysis, according to an aspect of the invention.", "FIG.", "2A illustrates an example of a scenario in which an IMU sensor is coupled to an object that is being filmed by a stationary image capture device and the motion of the object is being measured by the IMU sensor for generating haptic feedback, according to an aspect of the invention.", "FIG.", "2B illustrates an example of a scenario in which an IMU sensor is coupled to an object and an image capture device and the motion of the object is being measured by the IMU sensor for generating haptic feedback, according to an aspect of the invention.", "FIG.", "2C illustrates an example of a scenario in which an IMU sensor is coupled to an object that is being filmed by a moving image capture device and the motion of the object is being measured by the IMU sensor for generating haptic feedback, according to an aspect of the invention.", "FIG.", "3 illustrates examples of implementations of a computing device that is configured to generate haptic feedback based on video content analysis, according to an aspect of the invention.", "FIG.", "4 illustrates examples of implementations of a haptic output device that is incorporated into various user touch points, according to an aspect of the invention.", "FIG.", "5 illustrates an example of a process for generating haptic feedback based on video content analysis, according to an aspect of the invention.", "FIG.", "6 illustrates an example of a process for generating haptic feedback based on sensor information that includes one or more measurements of a motion of an object appearing on a video, according to an aspect of the invention.", "DETAILED DESCRIPTION The disclosure relates to systems and methods of generating haptic feedback based on video content analysis and/or sensor information that includes one or more measurements of motion of one or more objects appearing on a video, and/or sensor information that includes one or more measurements of motion of one or more image capture devices.", "FIG.", "1 illustrates a system 100 configured to generate haptic feedback based on video content analysis, according to an aspect of the invention.", "System 100 may include an Inertial Measurement Unit (“IMU”) sensor 110, a image capture device 120, a computing device 130, a computing device 140, a video output device 141, a haptic output device 143, an audio output device 145, and/or other components.", "Although only single ones of the foregoing components are illustrated in FIG.", "1, more than one of such components may be used.", "For example, one or more IMU sensors 110 may be used.", "IMU sensors 110 may individually operate at different frequencies and/or measurement ranges.", "In some implementations, different IMU sensors 110 may be attached to different objects and/or different image capture devices 120 related to a scene.", "In some implementations, IMU sensor 110 may include a three-dimensional (“3D”) gyroscope 111, a 3D accelerometer 113, a 3D magnetometer 115, and/or other sensor devices 117.Using 3D gyroscope 111, 3D accelerometer 113, 3D magnetometer 115, and/or other sensor devices 117, IMU sensor 110 may generate sensor information 112 that includes one or more measurements of a motion of IMU sensor 110.For example, when IMU sensor 110 is attached to an object, 3D gyroscope 111, 3D accelerometer 113, 3D magnetometer 115, and/or other sensor devices 117 may measure the motion of the object and generate the sensor information 112, which may be communicated to computing device 130.In some implementations, image capture device 120 may include a video camera and/or other image or image capture device.", "Image capture device 120 may capture one or more images and generate a video 122, which may be communicated to computing device 130.In some implementations, more than one image capture device 120 may film the same or different objects in a scene from different angles and/or other views.", "In some implementations, IMU sensor 110 may be attached to image capture device 120 such that the motion of the image capture device may be obtained and reported in sensor information 112.In some implementations, a first IMU sensor 110 may be attached to image capture device 120 and a second IMU sensor 110 may be attached to an object.", "Still another IMU sensor 110 may be attached to yet another object and/or another image capture device 120, and so on.", "In some implementations, computing device 130 may store sensor information 112 and/or video 122 in a database for later provisioning to computing device 140.Computing device 130 may provide sensor information 112 and/or video 122 to computing device 140.When sensor information 112 and video 122 are provided, sensor information 112 may be embedded within video 122 using conventional video formats that can accommodate data.", "Alternatively, computing device 130 may separately provide sensor information 112 and video 122.In some implementations, sensor information 112 and/or video 122 may be provided to computing device 140 in the form of one or more readable media 132, which may be generated by computing device 130 and/or other device.", "In some implementations, computing device 140 may include one or more processors 142 programmed with one or more computer program modules, which may be stored in one or non-transitory storage media 144.Computing device 140 may be programmed by the modules to perform image processing on video 122 and/or incorporate sensor information 112 to generate one or more control signals that cause haptic feedback based on the image processing on video 122 and/or use of sensor information 112.The modules may include an image processing module 150, a sensor processing module 152, an image-based motion estimator module 154, a sensor-based motion estimator module 156, a data fusion module 158, a configuration management module 160, a control signal generator module 162, a coordination module 164, and/or other modules.", "In some implementations, image processing module 150 may be configured to perform video content analysis on video 122.Whether video 122 is streamed from computing device 130, downloaded and stored locally for playback, read from media 132, and/or otherwise obtained in another manner, image processing module 150 may buffer video 122 in a memory to process one or more image frames of the video in order to detect one or more events of interest.", "Different types of events of interest may be detected in various ways.", "In some implementations, image processing module 150 may detect a movement in relation to a stationary object in a given scene by determining the optical flow of the object in relation to one image frame to another image frame.", "Such processing may indicate that the image capture device used to create video 122 was in motion.", "Image processing module 150 may determine the speed of the motion based on the image processing, which may trigger creation of the control signal that causes the haptic feedback.", "Image processing module 150 may perform conventional optical flow calculations, as would be apparent by those having skill in the art.", "In some implementations, image-based motion estimator module 154 may determine the speed, acceleration, and/or velocity of a motion of an object that appears on-scene based on the image processing using one or more videos 122.In implementations using more than one video 122, parallel video feeds may be used for stereovision, or otherwise to provide two or more different perspectives of a scene, which may improve accuracy of the motion estimate compared to using fewer video feeds or perspectives.", "Such speed, acceleration and/or velocity of the motion of the object may be included as a detected event that triggers creation of a control signal.", "In some implementations, image processing module 150 may detect that a new body part has entered a given scene based on comparison to a database of body parts (e.g., faces, hands, etc.).", "Entry of the new body part may indicate that a new character has entered the scene, which may trigger creation of the control signal that causes the haptic feedback.", "In some implementations, image processing module 150 may detect a change in the distribution or configuration of colors from one scene to the next (as reflected in the one or more image frames).", "For example, image processing module 150 may determine a Hue Saturation Value (“HSV”) color histogram for different such as consecutive frames and determine whether the HSV color histogram has changed from one frame to another frame.", "If the HSV color histogram has changed, image processing module 150 may determine that a new object or otherwise change in the scene has occurred.", "In some implementations, image processing module 150 may detect overall changes from light to dark and vice versa, potentially indicating an ambiance change of the scene, which may trigger creation of the control signal that causes the haptic feedback.", "In some implementations, the ambiance change of the scene may cause haptic feedback to be modulated based on the ambiance change.", "In some implementations, image processing module 150 may detect a mood or emotion of actors in a given scene based on conventional image processing and mood detection techniques, which may trigger creation of the control signal that causes the haptic feedback.", "In some implementations, image processing module 150 may detect a fire, explosion, and/or other occurrence in the video that may cause a particular pattern of color, which may trigger creation of the control signal that causes the haptic feedback.", "In some implementations, image processing module 150 may detect particular people or objects that appear on-screen.", "For example, a user may specify that a haptic feedback be provided when a particular object or person has entered a scene.", "Image processing module 150 may perform all or a portion of the foregoing and/or other event detection when processing the image frames.", "Responsive to the detected events, control signal generator module 162 may generate one or more control signals for causing the haptic feedback.", "The control signals may cause different haptic effects, depending on the event that was detected (e.g., faster image capture device and/or object motion may result in a control signal that causes a greater magnitude or other characteristic of haptic feedback than slower image capture device and/or object motion).", "Furthermore, image processing module 150 may generate different control signals (causing different haptic feedback) for different types and/or combinations of types of detected events.", "In some implementations, sensor processing module 152 may be configured to detect sensor-based events based on sensor information 112.For example, sensor-based events may include a particular motion of an object, a person, image capture device 120, and/or other motion in relation to video 122.In some implementations, sensor-based motion estimator module 156 may be configured to determine a speed, acceleration, velocity, and/or other characteristic of motion based on processing of sensor information 112.The sensor-based events may cause a control signal to be generated for providing a haptic feedback.", "The haptic feedback may vary based on the sensor-based event.", "As a particular example, when a motion of an object is detected, the control signal may be created to cause the haptic feedback.", "Such haptic feedback may vary based on the level of motion that was detected.", "In some implementations, sensor processing module 152 may synchronize sensor information 112 with video 122 based on whether a single device was used to generate the sensor information and the video (e.g., when a mobile device or other device having both sensors and image capture devices is used to both capture video and collect sensor information).", "If a single device was used to capture both the video and the sensor information, then both will typically be synchronized by the single device.", "On the other hand, if the single device does not synchronize the sensor information and the video, then sensor processing module 152 may synchronize the two based on timestamps that use a common time reference (e.g., Global Positioning System time), and/or event detection described herein.", "In some implementations, data fusion module 158 may be configured to combine the information from image processing module 150, sensor processing module 152, image-based motion estimator module 154, and/or sensor-based motion estimator module 156 for improving acceleration estimates of objects to thereby enhance the quality of the haptic feedback provided responsive to the acceleration estimates, as described further with respect to FIGS.", "2A-2C.", "In some implementations, configuration management module 160 may be configured to obtain user preferences or other inputs that indicate different haptic feedback or levels of haptic feedback that should be provided in response to detection of particular events.", "For example, a user may identify or specify events (if any) that trigger haptic feedback and/or levels of haptic feedback.", "In this manner, a user may customize video viewing and haptic feedback generation.", "In some implementations, control signal generator module 162 may be configured to generate one or more control signals that cause haptic feedback.", "Control signal generator module 162 may generate control signals responsive to the foregoing events detected by or outputs from image processing module 150, sensor processing module 152, image-based motion estimator module 154, sensor-based motion estimator module 156, data fusion module 158, and/or configuration management module 160.In some implementations, control signal generator 162 may generate control signals based on the particular configuration (e.g., number, type, placement, etc.)", "of one or more haptic output devices 143 that generate haptic feedback responsive to the control signals.", "In this manner, computing device 140 facilitates various types of haptic feedback responsive to different types of events, characteristics of events (e.g., estimated speed of an object appearing in a given scene), and/or user preferences/configurations.", "In some implementations, coordination module 164 may be configured to coordinate video output, control signal output, and audio output respectively to video output device 141, haptic output device 143, and audio output device 145.Video output device 141 may include a display such as a touchscreen display, a monitor, and/or other display that can display the video output.", "In some implementations, coordination module 164 may synchronize the video output, control signal (e.g., haptic feedback caused by the control signal), and audio output according to a synchronizing code embedded into video 122 and/or via time stamps that generally set a time for outputting each of the video output, audio output, and haptic feedback.", "Haptic output device 143 may include an actuator, for example, an electromagnetic actuator such as an Eccentric Rotating Mass (“ERM”) in which an eccentric mass is moved by a motor, a Linear Resonant Actuator (“LRA”) in which a mass attached to a spring is driven back and forth, or a “smart material” such as piezoelectric, electro-active polymers, or shape memory alloys, a macro-composite fiber actuator, an electro-static actuator, an electro-tactile actuator, and/or another type of actuator that provides a physical feedback such as a haptic (e.g., vibrotactile) feedback.", "The haptic output device 143 may include non-mechanical or non-vibratory devices such as those that use electrostatic friction (ESF), ultrasonic surface friction (USF), or those that induce acoustic radiation pressure with an ultrasonic haptic transducer, or those that use a haptic substrate and a flexible or deformable surface, or those that provide projected haptic output such as a puff of air using an air jet, and so on.", "Audio output device 145 may include speakers or other devices that can emit audio.", "In some implementations, video output device 141, haptic output device 143, and/or audio output device 145 may be integrated with computing device 140.In some implementations, video output device 141, haptic output device 143, and/or audio output device 145 may be housed separately from computing device 140.In some implementations, computing device 130 may be programmed with the modules discussed in relation to computing device 140.Thus, at least some or all of the functions described above with respect to computing device 140 may be performed at computing device 130.For instance, computing device 130 may perform image processing on videos that it creates and/or otherwise provides such that the provided videos are enhanced with control signals that may be synchronized with the provided video.", "In this manner, a user device that consumes the video and control signals may cause the video to be displayed and cause synchronized haptic feedback to be generated.", "Non-transitory storage media 144 may include one or both of system storage that is provided integrally (i.e., substantially non-removable) with computing device 140 and/or removable storage that is removably connectable to computing device 140 via, for example, a port (e.g., a USB port, a firewire port, etc.)", "or a drive (e.g., a disk drive, etc.).", "Non-transitory storage media 144 may include one or more of optically readable storage media (e.g., optical disks, etc.", "), magnetically readable storage media (e.g., magnetic tape, magnetic hard drive, floppy drive, etc.", "), electrical charge-based storage media (e.g., EEPROM, RAM, etc.", "), solid-state storage media (e.g., flash drive, etc.", "), and/or other electronically readable storage media.", "Non-transitory storage media 144 may include one or more virtual storage resources (e.g., cloud storage, a virtual private network, and/or other virtual storage resources).", "Non-transitory storage media 144 may store software algorithms, information determined by processor(s) 142, information received from computing device 140, and/or other information that enables computing device 140 to function as described herein.", "Processor(s) 142 are configured to provide information processing capabilities in computing device 140.As such, processor(s) 142 may include one or more of a digital processor, an analog processor, a digital circuit designed to process information, an analog circuit designed to process information, a state machine, and/or other mechanisms for electronically processing information.", "Although processor(s) 142 is illustrated in FIG.", "1 as a single entity, this is for illustrative purposes only.", "In some implementations, processor(s) 142 may include a plurality of processing units.", "These processing units may be physically located within the same device, or processor(s) 142 may represent processing functionality of a plurality of devices operating in coordination.", "Processor(s) 142 may be configured to execute modules by software; hardware; firmware; some combination of software, hardware, and/or firmware; and/or other mechanisms for configuring processing capabilities on processor(s) 142.The various modules described herein are exemplary only.", "Other configurations and numbers of modules may be used, as well using non-modular approaches so long as the one or more physical processors are programmed to perform the functions described herein.", "It should be appreciated that although modules 150, 152, 154, 156, 158, 160, 162, and 164 are illustrated in FIG.", "1 as being co-located within a single processing unit, in implementations in which processor(s) 142 includes multiple processing units, one or more modules may be located remotely from the other modules.", "The description of the functionality provided by the different modules described herein is for illustrative purposes, and is not intended to be limiting, as any of modules may provide more or less functionality than is described.", "For example, one or more of the modules may be eliminated, and some or all of its functionality may be provided by other ones of the modules.", "As another example, processor(s) 142 may be configured to execute one or more additional modules that may perform some or all of the functionality attributed herein to one of modules.", "The components illustrated in FIG.", "1 may be communicably coupled to one another via various communication links such as a network.", "The network may include wired or wireless connections.", "In some aspects of the invention, the network may include any one or more of, for instance, the Internet, an intranet, a PAN (Personal Area Network), a LAN (Local Area Network), a WAN (Wide Area Network), a SAN (Storage Area Network), a MAN (Metropolitan Area Network), a wireless network, a cellular communications network, a Public Switched Telephone Network, and/or other network.", "Various inputs, outputs, configurations, and/or other information described herein as being stored or storable may be stored in one or more databases (not illustrated in FIG.", "1).", "Such databases may be, include, or interface to, for example, an Oracle™ relational database sold commercially by Oracle Corporation.", "Other databases, such as Informix™, DB2 (Database 2) or other data storage, including file-based, or query formats, platforms, or resources such as OLAP (On Line Analytical Processing), SQL (Standard Query Language), a SAN (storage area network), Microsoft Access™ or others may also be used, incorporated, or accessed.", "The database may comprise one or more such databases that reside in one or more physical devices and in one or more physical locations.", "The database may store a plurality of types of data and/or files and associated data or file descriptions, administrative information, or any other data.", "FIG.", "2A illustrates an example of a scenario 200A in which an IMU sensor 110 is coupled to an object 202A that is being filmed by a stationary image capture device 120 and the motion of object 202A is being measured by IMU sensor 110 for improving the accelerations estimate of object 202A, according to an aspect of the invention.", "The image capture device frames information and basic knowledge of object 202A, which may be of interest, may be used to estimate its 3D movement and its position in the fixed image capture device referential using conventional computer vision approaches.", "IMU sensor 110 attached to object 202A may provide inertial data estimation that will be made more accurate using the data provided by the image capture device 120.The object 202A that is used as the basis for providing haptic feedback may be chosen by a user in advance.", "Image-based motion estimator module 154 may determine the acceleration of object 202A by detecting object 202A in two or more consecutive images (given its characteristics or some of its feature points) using a conventional template matching approach (e.g.", "optical flow, Histogram of Oriented Gradients (“HOG”), 3D model pose estimation, etc.).", "In some implementations, data fusion module 158 may determine the motion of object 202A by combining its motion estimated by image-based motion estimator module 154 with the motion estimated by the sensor-based motion estimator 156 FIG.", "2B illustrates an example of a scenario 200B in which an IMU sensor 110 is coupled to an object 202B and an image capture device 120 and the motion of object 202B is being measured by IMU sensor 110 for improving the accelerations estimate of object 202B, according to an aspect of the invention.", "Image-based motion estimator module 154 may apply computer vision algorithms to estimate the 3D camera pose (position and orientation in a fixed referential) from successive frames using some visual fix invariant features in the scene.", "Estimating the camera pose may be equivalent to estimating the object pose in this case.", "The estimated data may be combined to that provided by IMU sensor 110 attached to object 202B in order to make it more accurate using data fusion module 158.If the haptic feedback is relative to the image capture device 120's movement, only the intrinsic parameters of the image capture device may be used.", "Image-based motion estimator module 154 may determine the optical flow for some invariant stationary features in the scene (e.g.", "Scale-Invariant Feature Transforms, Speeded Up Robust Features, etc.).", "The movement of the image capture device 120/object 202B would be the inverse of the calculated optical flow.", "FIG.", "2C illustrates an example of a scenario 200C in which an IMU sensor 110 is coupled to an object 202C that is being filmed by a moving image capture device 120 and the motion of the object is being measured by IMU sensor 110 for improving the accelerations estimate of object 202C, according to an aspect of the invention.", "In some implementations (not illustrated in FIG.", "2C) IMU sensor 110 may be coupled to image capture device 120 to provide one or more measurements of its motion.", "Image-based motion estimator module 154 may apply computer vision algorithms to estimate the 3D camera pose (position and orientation in a fixed referential) from successive frames using some visual fix invariant features in the scene.", "The image capture device frames information and basic knowledge of characteristics of object 202C can be used to estimate its 3D movement and its position in the image capture device referential using computer vision approaches.", "The object position and movement can then be translated to a global fixed referential and fused with the sensor information from IMU 110 using data fusion module 158.The intrinsic parameters of the image capture device and the characteristics of the objects/person in the video feed, for which the haptic feedback would be created, may be used.", "Image-based motion estimator module 154 may determine the movement of the image capture device 120 by calculating the optical flow for some invariant stationary features in the scene.", "Using data fusion module 158 this movement can be estimated with higher precision if an IMU sensor 110 is coupled with image capture device 120.By template matching, Using data fusion module 158 this movement can be estimated with higher precision if an IMU sensor is coupled with the device 120 may estimate the relative movement of object 202C in the scene.", "By correlating both values, the movement in a fix referential is then evaluated.", "FIG.", "3 illustrates examples of implementations of the computing device 140 that is configured to generate haptic feedback based on video content analysis, according to an aspect of the invention.", "Computing device 140A may be configured as a mobile device such as a smartphone having an integrated video output device 141 (e.g., a touchscreen display), an integrated haptic output device 143, and an integrated audio output device 145.In this implementation, computing device 140A may be used to view video content while receiving haptic feedback through the mobile device.", "In some implementations, an external haptic device can also be coupled to computing device 140A via a wired or wireless connection.", "Computing device 140B may be configured as a portable computing device such as a laptop computer having an integrated haptic output device 143, and an integrated audio output device 145.In this implementation, computing device 140B may be used to view video content while receiving haptic feedback through the portable computing device.", "In some implementations, an external haptic device can also be coupled to computing device 140B via a wired or wireless connection.", "Computing device 140C may be configured as a standalone computing device such as a desktop computer, a gaming console, or other standalone computing device.", "In this implementation, computing device 140C may be coupled to a separate video output device 141, a separate audio output device 145, and a separate user touch point 302, which may house the haptic output device 143.FIG.", "4 illustrates examples of implementations of a haptic output device 143 that is incorporated into various user touch points 302, according to an aspect of the invention.", "For example, touchpoints 302A and 302B may be configured as wearable devices such as wearable glasses and wearable garments.", "Other types of wearable devices may be used as well.", "Touch point 302C may be configured as various user devices that include haptic output devices 143 (illustrated in FIG.", "4 as haptic output devices 143A, 143B, .", ".", ".", "143C), which may include devices such as smartphones, keyboards, mice, game controllers, and/or other user devices.", "FIG.", "5 illustrates an example of a process 500 for generating haptic feedback based on video content analysis, according to an aspect of the invention.", "The various processing operations depicted in the flowchart of FIG.", "5 and other drawing Figures are described in greater detail herein.", "The described operations may be accomplished using some or all of the system components described in detail above.", "According to an aspect of the invention, various operations may be performed in different sequences.", "In other implementations, additional operations may be performed along with some or all of the operations shown in FIG.", "5 and other drawing figures, or some operations may be omitted.", "In yet other implementations, one or more operations may be performed simultaneously.", "Accordingly, the operations as illustrated (and described in greater detail below) are exemplary in nature and, as such, should not be viewed as limiting.", "In an operation 502, a video having one or more image frames may be obtained, which may include captured and/or read.", "In an operation 504, image processing may be performed on the one or more image frames.", "In an operation 506, an event based on the image processing may be detected.", "In an operation 508, a control signal based on the detected event may be provided.", "The control signal may cause a haptic output device to provide a haptic feedback.", "Thus, haptic feedback may be generated based on image processing being performed on a video.", "FIG.", "6 illustrates an example of a process 600 for generating haptic feedback based on sensor information that includes one or more measurements of a motion of an object appearing on a video, according to an aspect of the invention.", "In an operation 602, a video and sensor information associated with the video may be obtained, which may include captured and/or read.", "The sensor information may include one or more measurements of a motion captured in relation to the video.", "The motion may include a motion of an object, a motion of an image capture device being moved while capturing the video, and/or other motion that can be measured in relation to the video.", "In an operation 604, a control signal based on the sensor information may be generated.", "The control signal may be configured to cause a haptic feedback.", "In some implementations, the control signal may be based on the sensor information and output of image processing of the video.", "In an operation 606, the control signal may be provided in synchronization with the motion captured in relation to video.", "Other aspects, uses and advantages of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein.", "The specification should be considered exemplary only, and the scope of the invention is accordingly intended to be limited only by the following claims." ] ]
Patent_15874131
[ [ "High-Throughput Single Cell Barcoding", "Methods and compositions for high-throughput, single cell analyses are provided.", "The methods and compositions can be used for analysis of genomes and transcriptomes, as well as antibody discovery, HLA typing, haplotyping and drug discovery." ], [ "1.A method for high-throughput sequencing of nucleic acids from a plurality of biological samples comprising (a) generating at least two bar-codes attached to a solid support, (b) delivering each of the at least two bar-codes to individual samples of the plurality of biological samples, (c) sequencing a nucleic acid from at least two of the plurality of biological samples; and (d) correlating the nucleic acid sequence to a single sample of the plurality of biological samples through bar-code sequencing identification.", "2.The method of claim 1 wherein the analysis is of a genome.", "3.The method of claim 1 wherein the analysis is of a transcriptome.", "4.The method of claim 1 wherein the solid support is a bead.", "5.The method of claim 1 wherein the bar-codes are made by Rolony generation.", "6.The method of claim 1 wherein delivery is by transfection, by emulsification, or using liposomes.", "7.The method of claim 1 wherein the delivery of each of the at least two bar-codes to individual samples of the plurality of biological samples is in a single assay.", "8.The method of claim 1 wherein the biological samples are cells.", "9.The method of claim 8 wherein the cells are selected from the group consisting of cells in in vitro culture, stem cells, tumor cells, tissue biopsy cells, blood cells, and tissue section cells.", "10.The method of claim 1 wherein the samples are metagenomic samples.", "11.The method of claim 9 wherein the blood cells are T-lymphocytes or B-lymphocytes.", "12.The method of claim 9 wherein the stem cells are embryonic stem cells or induced pluripotent stem cells.", "13.The method of claim 1 wherein the samples are selected from the group consisting of bacteria, viruses, fungi, and hybdridomas.", "14.The method of claim 1 wherein the nucleic acid is a DNA or an RNA.", "15.A method of preparing bar-code oligonucleotides on a solid support comprising steps of (i) attaching an initial template oligonucleotide to a solid support, wherein the initial template oligonucleotide comprises a nucleotide sequence encoding (a) a sequencing primer, (b) a bar-code, and (c) an annealing primer, (ii) saturating the solid support with a plurality of anchor primers, and (iii) performing emulsion PCR.", "16.The method of claim 15 wherein the solid support is a bead.", "17.A solid support comprising a plurality of oligonucleotides wherein each oligonucleotide comprises a nucleotide sequence encoding: (i) a sequencing primer, (ii) a bar-code, and (iii) an annealing primer which targets a nucleic acid of interest.", "18.The solid support of claim 17 wherein the solid support is a bead.", "19.The solid support of claim 17 wherein the annealing primer comprises an oligo (dT) primer.", "20.The solid support of claim 17 wherein at least two of the plurality of oligonucleotides encode annealing primers which target different nucleic acids of interest." ], [ "<SOH> BACKGROUND <EOH>Classical single cell analysis is performed by isolating a single cell into a single well of a processing plate from which DNA and/or RNA can be amplified or where the cell can be subculture into a larger population, with both approaches performed until enough genomic material is achieved for subsequent downstream processing.", "A limitation of such approaches is that it is not always possible to isolate single cells from a tissue section or a complex cellular mixture or population.", "Furthermore, in a clonally amplified cell population in culture, even if the cells should present the exact same genome, which they should in theory, the transcriptomic information is variable from one cell to another.", "Also, culturing cells modifies their expression patterns, so it is often preferable to capture the transcriptomic information when the cells are in their original environment.", "In addition, the extreme low amounts of DNA and/or RNA obtained when isolating a single cell makes downstream processing steps quite challenging.", "Moreover, the processes by which DNA and/or RNA are amplified to large enough amounts to allow such analysis causes significant bias in the resulting material and, therefore, is not representative of the nucleic acids in the cell.", "Finally, classical approaches are limited in the amount of single cells that can be assayed in one analysis.", "For example, a complex population of 10,000 cells is to be studied, 10,000 cells would need to be sorted and separated (using, e.g., approximately 100×96 well plates), which requires substantial investment in costly automation equipment as well as significant processing time and additional costs.", "Early approaches included split pooled DNA synthesis.", "While split pooled DNA synthesis on beads can potentially be used to achieve uniquely bar-coded beads (Brenner et al.", "(2000) Proc.", "Natl.", "Acad.", "Sci.", "USA 97:1665), the technical difficulties associated with such an approach and the incorporation inefficiency of nucleotide during chemical synthesis of the sequence, results in beads having very few oligonucleotide sequences with correct sequences and/or length.", "Even when nucleotide synthesis chemistry is quite efficient, there is, on average, 1% non-incorporation at each nucleotide cycle.", "Consequently, attempts to synthesize a clonal bar-code on beads of proper length split pooled DNA synthesis were unsuccessful.", "For example, for a typical oligonucleotide of 50-60 nucleotides this error rate would result in less than 40% of the oligos on the beads having the correct sequence.", "Moreover, because the oligonucleotides are synthesized on a solid support it is impossible to identify the correct one, using purification approaches such as with HPLC purification or PAGE.", "Split pool synthesis was originally developed by Linx Therapeutics, who was acquired by Solexa who was acquired by Illumina based on the early work on split pool synthesis, but the technology was abandoned because of these issues.", "Thus, the efficient use of bar-coded beads has not been achieved.", "Beads with an internal dye gradient core (such as the one used by Luminex Corporation) can be used in application where the overall bead bar-code signal is used.", "While that approach is acceptable when an average signal intensity is desired, it is inadequate where the downstream use of these molecules requires unique identification of the cell.", "Also “luminex beads” can only be generated in a limited amount which result in limited capability for probing more then a few hundreds of cells.", "The present approach offers particular advantages over earlier approaches such as split pooled DNA synthesis on bead." ], [ "<SOH> SUMMARY <EOH>The present approach efficiently produces bar-coded beads coated with clonal copies of the bar-coded oligonucleotides having the correct sequence.", "Moreover, the speed, ease and cost of production is also advantageous.", "And, unlike split pooled DNA synthesis on beads, millions of uniquely bar-coded beads can be generated for single cell analysis.", "In one aspect, the invention consists of an approach for bar-coding many single cells in a complex mixtures of cells.", "Each cell is provided with a unique individual bar-code for each cell.", "The unique bar-code allows each cell's nucleic acids (genome or transcriptome) to be associated with the original cell.", "Thus, for any given individual cell multiple different genes and transcripts can be identified and correlated to the same cell because the sequences share the same unique bar code.", "The unique bar-code is inserted into each individual cell in a way that each cell receives one unique bar-code and is present in a large enough amount to allow subsequent genomic or transcriptomic targeting.", "Once the bar-code is inserted, downstream manipulations are conducted to capture and then sequence all these unique bar-codes and the genome or transcriptome sequences of interest in one simultaneous reaction.", "The present approach, when coupled with high-throughput sequencing technology allows analyzing a large number of single cells and achieving the analysis in one single reaction assay.", "In principle, one can sequence any number of cells and any number of targeted regions per cell.", "The number of single cells that can be processed is limited only by practical constraints, such as the speed of high throughput sequencing; for example.", "In some embodiments, high-throughput sequencing technologies are used, such as the ones conducted of sequencing platform such as Illumina HiSeq or genome analyzer, Roche 454, Pacific Bioscience, Ion Torrents, Harvard Polonator, ABI Solid or other similar instruments in the field.", "Classic sequencing approaches, such as Sanger sequencing can be used; however, the true power in the technology is to be able to sequence a larger number of sequences from single cells simultaneously.", "High-throughput sequencing platforms are thus better-suited for most embodiments.", "If a sequencing platform generates 10 million reads per run, then one can sequence one unique transcript across 1 million cells to achieved a 10× coverage.", "In other embodiments, a partial transcriptome, for example targeting 10,000 unique transcripts, requires only 100 cells to be targeted for capture and sequencing.", "In some embodiments, full or targeted transcriptome RNA analysis is performed.", "Thus, in a single cell, only selected transcripts may be sequenced.", "In other applications, all or substantially all transcripts may be captured and sequenced.", "In yet other embodiments, full or partial genomic DNA analysis is performed.", "Analyses of multiple cells in heterogeneous cell populations is particularly useful when studying complex samples or mixtures.", "Complex samples or cell mixtures include, for example, metagenomic samples, normal and cancerous tissue sections, embryonic and stem cell colonies.", "Genome and transcriptome sequencing is desirable where sequences are highly divergent; for example, in certain cell types or in cells at certain stages.", "Particularly suitable applications include molecular haplotyping, HLA typing, and T- and B- cell receptor profiling.", "Metagenomic samples refers to samples containing genomes from multiple origins, such as species.", "For example, the present approach may be applied to mixtures of bacterial species to allow sequencing of nucleic acids from multiple bacteria in one assay followed by correlating the sequences to the same bacterial cell.", "Similarly, nucleic acid sequences of foreign cells living in the mouth can be determined and correlated to the same cell.", "Further features and advantages of certain embodiments of the present invention will become more fully apparent in the following description of the embodiments and drawings thereof, and from the claims." ], [ "RELATED APPLICATION DATA This application is a continuation application which claims priority to U.S. patent application Ser.", "No.", "13/878,406, filed on May 21, 2013, which is a National Stage Application under 35 U.S.C.", "371 of co-pending PCT application PCT/US2011/055803 designating the United States and filed Oct. 11, 2011; which claims the benefit of U.S.", "Provisional Application No.", "61/391,364 and filed Oct. 8, 2010 each of which are hereby incorporated by reference in their entireties.", "STATEMENT OF GOVERNMENT INTERESTS This invention was made with government support under HG003170 awarded by the National Institutes of Health.", "The Government has certain rights in the invention.", "FIELD The present invention relates to methods and compositions for obtaining and analyzing nucleic acid sequences derived from many single cells at once.", "BACKGROUND Classical single cell analysis is performed by isolating a single cell into a single well of a processing plate from which DNA and/or RNA can be amplified or where the cell can be subculture into a larger population, with both approaches performed until enough genomic material is achieved for subsequent downstream processing.", "A limitation of such approaches is that it is not always possible to isolate single cells from a tissue section or a complex cellular mixture or population.", "Furthermore, in a clonally amplified cell population in culture, even if the cells should present the exact same genome, which they should in theory, the transcriptomic information is variable from one cell to another.", "Also, culturing cells modifies their expression patterns, so it is often preferable to capture the transcriptomic information when the cells are in their original environment.", "In addition, the extreme low amounts of DNA and/or RNA obtained when isolating a single cell makes downstream processing steps quite challenging.", "Moreover, the processes by which DNA and/or RNA are amplified to large enough amounts to allow such analysis causes significant bias in the resulting material and, therefore, is not representative of the nucleic acids in the cell.", "Finally, classical approaches are limited in the amount of single cells that can be assayed in one analysis.", "For example, a complex population of 10,000 cells is to be studied, 10,000 cells would need to be sorted and separated (using, e.g., approximately 100×96 well plates), which requires substantial investment in costly automation equipment as well as significant processing time and additional costs.", "Early approaches included split pooled DNA synthesis.", "While split pooled DNA synthesis on beads can potentially be used to achieve uniquely bar-coded beads (Brenner et al.", "(2000) Proc.", "Natl.", "Acad.", "Sci.", "USA 97:1665), the technical difficulties associated with such an approach and the incorporation inefficiency of nucleotide during chemical synthesis of the sequence, results in beads having very few oligonucleotide sequences with correct sequences and/or length.", "Even when nucleotide synthesis chemistry is quite efficient, there is, on average, 1% non-incorporation at each nucleotide cycle.", "Consequently, attempts to synthesize a clonal bar-code on beads of proper length split pooled DNA synthesis were unsuccessful.", "For example, for a typical oligonucleotide of 50-60 nucleotides this error rate would result in less than 40% of the oligos on the beads having the correct sequence.", "Moreover, because the oligonucleotides are synthesized on a solid support it is impossible to identify the correct one, using purification approaches such as with HPLC purification or PAGE.", "Split pool synthesis was originally developed by Linx Therapeutics, who was acquired by Solexa who was acquired by Illumina based on the early work on split pool synthesis, but the technology was abandoned because of these issues.", "Thus, the efficient use of bar-coded beads has not been achieved.", "Beads with an internal dye gradient core (such as the one used by Luminex Corporation) can be used in application where the overall bead bar-code signal is used.", "While that approach is acceptable when an average signal intensity is desired, it is inadequate where the downstream use of these molecules requires unique identification of the cell.", "Also “luminex beads” can only be generated in a limited amount which result in limited capability for probing more then a few hundreds of cells.", "The present approach offers particular advantages over earlier approaches such as split pooled DNA synthesis on bead.", "SUMMARY The present approach efficiently produces bar-coded beads coated with clonal copies of the bar-coded oligonucleotides having the correct sequence.", "Moreover, the speed, ease and cost of production is also advantageous.", "And, unlike split pooled DNA synthesis on beads, millions of uniquely bar-coded beads can be generated for single cell analysis.", "In one aspect, the invention consists of an approach for bar-coding many single cells in a complex mixtures of cells.", "Each cell is provided with a unique individual bar-code for each cell.", "The unique bar-code allows each cell's nucleic acids (genome or transcriptome) to be associated with the original cell.", "Thus, for any given individual cell multiple different genes and transcripts can be identified and correlated to the same cell because the sequences share the same unique bar code.", "The unique bar-code is inserted into each individual cell in a way that each cell receives one unique bar-code and is present in a large enough amount to allow subsequent genomic or transcriptomic targeting.", "Once the bar-code is inserted, downstream manipulations are conducted to capture and then sequence all these unique bar-codes and the genome or transcriptome sequences of interest in one simultaneous reaction.", "The present approach, when coupled with high-throughput sequencing technology allows analyzing a large number of single cells and achieving the analysis in one single reaction assay.", "In principle, one can sequence any number of cells and any number of targeted regions per cell.", "The number of single cells that can be processed is limited only by practical constraints, such as the speed of high throughput sequencing; for example.", "In some embodiments, high-throughput sequencing technologies are used, such as the ones conducted of sequencing platform such as Illumina HiSeq or genome analyzer, Roche 454, Pacific Bioscience, Ion Torrents, Harvard Polonator, ABI Solid or other similar instruments in the field.", "Classic sequencing approaches, such as Sanger sequencing can be used; however, the true power in the technology is to be able to sequence a larger number of sequences from single cells simultaneously.", "High-throughput sequencing platforms are thus better-suited for most embodiments.", "If a sequencing platform generates 10 million reads per run, then one can sequence one unique transcript across 1 million cells to achieved a 10× coverage.", "In other embodiments, a partial transcriptome, for example targeting 10,000 unique transcripts, requires only 100 cells to be targeted for capture and sequencing.", "In some embodiments, full or targeted transcriptome RNA analysis is performed.", "Thus, in a single cell, only selected transcripts may be sequenced.", "In other applications, all or substantially all transcripts may be captured and sequenced.", "In yet other embodiments, full or partial genomic DNA analysis is performed.", "Analyses of multiple cells in heterogeneous cell populations is particularly useful when studying complex samples or mixtures.", "Complex samples or cell mixtures include, for example, metagenomic samples, normal and cancerous tissue sections, embryonic and stem cell colonies.", "Genome and transcriptome sequencing is desirable where sequences are highly divergent; for example, in certain cell types or in cells at certain stages.", "Particularly suitable applications include molecular haplotyping, HLA typing, and T- and B- cell receptor profiling.", "Metagenomic samples refers to samples containing genomes from multiple origins, such as species.", "For example, the present approach may be applied to mixtures of bacterial species to allow sequencing of nucleic acids from multiple bacteria in one assay followed by correlating the sequences to the same bacterial cell.", "Similarly, nucleic acid sequences of foreign cells living in the mouth can be determined and correlated to the same cell.", "Further features and advantages of certain embodiments of the present invention will become more fully apparent in the following description of the embodiments and drawings thereof, and from the claims.", "BRIEF DESCRIPTION OF THE DRAWINGS The patent or application file contains at least one drawing executed in color.", "Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.", "The foregoing and other features and advantages of the present invention will be more fully understood from the following detailed description of illustrative embodiments taken in conjunction with the accompanying drawings in which: FIGS.", "1A-1E schematically depict a method of amplifying each unique molecule composed of a degenerate barcode on a bead according to certain aspects of the invention.", "(A) Attach barcoded template oligonucleotide.", "(B) saturate solid support with anchor primer.", "(C) Perform emulsion PCR.", "(D) Emulsion PCR completed.", "(E) Barcoded beads are recovered.", "FIGS.", "2A-2D schematically depict emulsion PCR of a single cell.", "(A) Capture of cell and barcoded bead in an emulsion.", "(B) Lyse cell.", "(C) Anneal DNA and/or RNA to barcoded bead followed by primer extension and/or reverse transcription.", "FIGS.", "3A-3D schematically depict downstream processing of recovered beads bound to barcoded fragments.", "(A) Example of one RNA template.", "(B) Second strand synthesis.", "(C) Gene specific primer, restriction digest or universal adapter ligation.", "(D) Recovered barcoded DNA, ready for high-throughput sequencing.", "FIG.", "4 depicts beads according to certain aspects of the invention.", "Cy 5 shows presence of an adenine nucleotide at position one of the bar-code.", "Cy3 the shows presence of a thymine nucleotide at position one of the bar-code Texas Red (TxRed) shows the presence of a cytosine nucleotide at position one of the bar-code.", "Fluorescein isothiocyanate (FITC) shows the presence of a guanine at position one of the bar-code.", "Sequentially sequencing each position of the bar-code provides the unique bar-code identifier.", "Each transcript captured by the beads can be correlated to a unique starting cell because each cell is represented by a unique bar-code.", "FIGS.", "5A-5G depicts a method to generate multiple copies of a uniquely degenerate barcode for single cell analysis according to certain aspects of the invention.", "(A) Reverse DNA (i.e., starting) template.", "(B) Circularizing by ligation.", "(C) Rolling circle amplification using strand displacing polymerase and complementary primer.", "(D) Inserting into liposome or emulsion with restriction complementary sequence and restriction enzyme.", "(E) Resulting barcoded oligonucleotides.", "Each liposome or emulsion contains a unique, degenerate barcode.", "(F) Each liposome can be fused directly with a single cell (or each barcoded emulsion can be fused with one cell in emulsion).", "(G) Sequencing query of the barcode region of rolling circle amplification (Rolony) demonstrated clonality.", "Rolonies were ordered on a grid of 250 nanometer size features.", "FIGS.", "6A-6B depicts a method to generate multiple copies of a uniquely degenerate barcode for single cell analysis according to certain aspects of the invention relating to targeting more than one nucleic acid sequence of interest.", "The left panel in FIGS.", "6A and 6B shows an oligo-dT sequence annealing primer, which can target polyA tails of mRNAs found in a cell.", "The right panel in FIGS.", "6A and 6B demonstrates using a “universal sequence” primer, which has a sequence complementary to an overhang common to several annealing primer sequences, to generate a bead having oligonucleotides that anneal to multiple different nucleic acid targets of interest (shown in red and blue at the 3′ end of the oligonucleotide.)", "FIGS.", "7A-7E show bead clonality using different concentrations of primer.", "(FIG.", "7A: 0.1 pM; FIG.", "7B: 1 pM, FIG.", "7C: 10 pM, and FIG.", "7D: 100 pM).", "FIG.", "7E shows the 100 pM sample overlaid with beads.", "See Example 1.FIGS.", "8A-8H shows bead clonality in emulsions.", "FIG.", "8A shows overlay of uniquely bar-coded beads over white light, showing clonality of beads with an optimal amount of starting template.", "FIG.", "8B shows one cycle sequencing of the bar-code on the fluorescence channels only.", "FIG.", "8C shows white light only.", "FIG.", "8D shows single bead capture in emulsion.", "FIG.", "8E shows bar-coded beads in presence of lysed cells in emulsion post-amplification.", "FIGS.", "8F and G are magnifications of FIG.", "8E.", "FIG.", "8H shows introduction of fluorescent bar-codes in single cells FIGS.", "9A-9C shows sequences used in aspects of the invention.", "FIG.", "9A shows 5′ and 3′ sequences of a primer (SEQ ID NOs:1 and 10, respectively) used in the Illumina system.", "FIG.", "9B shows 5′ and 3′ sequence of a primer (SEQ ID NOs:2 and 11, respectively) used in aspects of the invention, including anchor sequence primer, 20-nucleotide bar-code position (--BC(N20)--), and oligo dT sequence.", "The cluster sequences facilitate sequencing in the Illumina system.", "FIG.", "9C shows a sample oligonucleotide attached to a bead having an anchor sequence primer, 20-nucleotide bar-code (--BC(N20)--), and oligo dT sequence (SEQ ID NO:3).", "DETAILED DESCRIPTION In certain aspects, the methods and compositions described herein are useful for single cells analysis, such as, e.g., for the study of genomes, transcriptomes, proteomes, metabolic pathways and the like of complex cell samples.", "In other aspects, the methods and compositions described herein can be used for antibody discovery by pairing heavy and light chain in single B and T cells, as well as for HLA typing, and long range haplotyping.", "In still other aspects, the methods and compositions described herein can be used to monitor the impact of small molecule and drugs and their effect in complex normal or cancerous samples for the discovery of new drugs.", "In yet other aspect, the methods and composition can be used to detect and analyze pathogens such as bacteria or viruses in biological samples.", "In certain exemplary embodiments, methods are provided for creating clonal copies of barcode sequences (e.g., degenerate barcodes) and delivering the barcode sequences into a plurality of single cells.", "According to one aspect of the invention, a plurality of unique nucleic acid sequences comprising a degenerate barcode are amplified on a support (e.g., a bead) such that each discrete area of the support (e.g., each bead) will be coated with clonal copy of a starting nucleic acid sequence (FIG.", "1).", "Accordingly, each discrete area of a support; bead, for example, will be uniquely barcoded with a plurality of targeting barcode oligonucleotides.", "In certain exemplary embodiments, emulsion PCR is performed, wherein degenerate oligonucleotide sequences are attached to a bead using a dilution equivalent maximum of one molecule per bead.", "The bar-code oligonucleotide length is related to cell sample size of interest.", "Generally, bar-codes are at least 3 nucleotides long.", "Often, they are about 20 nucleotides.", "Thus, for example, a support-attached oligonucleotide having a total length of about 50-60 nucleotides, includes nucleotides encoding a sequencing primer, 20 nucleotides for the bar-code, and an annealing primer.", "In some embodiments, the support is a bead.", "The initial template oligonucleotide loaded on the beads has a sequencing primer region (which will be used to facilitate sequencing of the bar-code), a degenerate region (the actual bar-code) and an annealing primer region, which has a sequence complementary to the target nucleic acid sequence or sequences of interest.", "The annealing primer can be DNA or RNA (FIG.", "1A).", "Some beads may contain oligonucleotides that bind to more than one target nucleic acid of interest.", "The beads are then saturated with an anchor primer.", "(FIG.", "1B).", "The anchor primer has the same sequence as the sequencing primer region of the template oligonucleotide.", "The anchor primer serves as the second PCR priming end, which allows attachment of the product generated during emulsion PCR to the beads.", "The beads are then amplified in emulsion PCR (FIG.", "1C) using a primer complementary to the annealing section of the starting molecule.", "When emulsion PCR is complete, the anchor primer is extended and contains a copy of the bar-code and the annealing primer.", "The bead can subsequently be purified from the emulsions and used in downstream applications.", "Once the bar-coded beads are prepared, they are used in a second emulsion PCR in the presence of a single cell.", "The cell is contained within its own unique emulsion, allowing simultaneous PCR in a single assay that contains many cells.", "(FIG.", "2).", "The beads and cells may be introduced to each other in any suitable way.", "For example, by transfection using liposomes, or by emulsification.", "Samples containing multiple beads and multiple cells are diluted to achieve a maximum of one bead and one cell per emulsion PCR reaction.", "In FIG.", "2, an example of one bead-cell event is shown.", "In some embodiments, thousands to millions of the events shown in FIG.", "2 may be performed in a single assay, such as one assay performed in a single well.", "Each single cell is sequestered into its own unique emulsion in the presence of one bar-coded beads.", "The multiple reaction are in the same reaction volume for all the cells.", "Because so many cells are analyzed in a single assay, the approach is equivalent to mixing millions of wells of PCR plates.", "Therefore a single assay is not limited in the amount of single cells to target, or the amount of transcript to target per single cells, provided each cell is uniquely bar-coded in either single emulsion per cell or through liposome transfection of a single bead or bar-code system.", "See FIG.", "2A.", "Millions of emulsions can be present in a single assay; i.e in a single well.", "Upon cell lysis, the nucleic acid target of interest is annealed to the complementary sequences on the bar-coded bead template.", "FIG.", "2B.", "Reverse transcription, for a RNA target, or primer extension, for a DNA target, is performed, and appends a bar-code to the cell RNA or DNA target.", "FIG.", "2D.", "Within one cell, the same bar-code is added to all the target sequences.", "Thus, as shown in FIG.", "2D, Cell number 1, bead bar code number 1 has captured four examples of the target sequence (green, yellow, purple, and red).", "Each independent cell in the reaction has a different bar code.", "FIG.", "2D.", "DNA from Beads with bar-coded fragments of interest are recovered and processed in downstream assays.", "When the bead has RNA attached, cDNA synthesis is performed, followed by PCR amplification using gene specific primer (or restriction cleavage, and/or adapter ligation, follow by PCR) similarly to what has been described previously (Kim et al.", "(2007) Science 316:1481).", "See FIG.", "3.Sequencing of DNA using high-throughput technology is then performed.", "The sequencing primer is used to sequence the bar-code, through the annealing primer into the target sequence.", "The target sequencing conveys transcript identity and expression levels, or other genomic or transcriptomic sequence of interest.", "The bar-code sequence allows each target sequence to be correlated to the single cell from which the sequences originated.", "While each transcript originating from one cell will have the same bar-code sequence, variation in genomic or transcriptomic information across the cell population is determined by assaying many single cells at the same time.", "Because each single cell contains a unique bar-code different from the other single cells, the identified sequences having the same bar-code can be correlated to the same originating cell.", "In certain embodiments, multiple mRNAs from each single cell can be obtained and analyzed.", "For example, oligo-dT (or similar primers) may be used as the annealing primer.", "See FIGS.", "6A and 6B.", "The oligo-dT sequence anneals to mRNA polyA tails and thus capture simultaneously multiple messenger RNAs from a single cell.", "This allows for complete or substantially complete transcriptome analysis of multiple single cells in a complex mixture.", "Characterizing the transcriptomes of multiple cells on a per-cell basis has particular application in studies investigating which cells are malignant than others cancer samples.", "Moreover, in patients undergoing cancer therapy, the present approach provides for monitoring mutation of each cell's genome and transcriptome before and after treatment; for example with a drug, or following surgery.", "This information is particularly useful when coupled with medicines known to be affected by the sequence of a protein.", "For example, the EGFR inhibitor Erbitux® (cetuximab) is ineffective when used with certain mutations of K-ras.", "The present approach can be used diagnostically to determine, down to the single cell level, how many cells in a tumor sample carry the mutations that make the cells Erbitux® resistant.", "Information regarding the nucleic acid sequences of multiple proteins in each tumor cell is valuable in determining whether to continue or stop treatment with a given drug or switch to an alternative drug.", "In another embodiment, at least two oligonucleotides having different annealing primers are attached to the same bead, which allows several target nucleic acids in the same cell to be captured and sequenced.", "To produce beads containing different annealing primers a universal sequence is attached downstream of the bar-code primer.", "See FIGS.", "6A and 6B.", "The universal sequence is complementary to an overhang region on a second primer that contains the annealing primer, which targets the gene of interest.", "Multiple annealing primers, each targeting a different gene of interest, may be used.", "The universal sequence, common to the overhangs of all the annealing primers allows incorporation of the multiple annealing primer sequences onto the beads by PCR.", "See FIGS.", "6A and 6B.", "Beads with multiple annealing primers targeting different nucleic acids of interest have particular use in immune cell applications.", "In one embodiment, specific sets of targeting oligonucleotides complementary to the heavy and light chains of the B cell antibody coding gene or its RNA are used to capture the pairing of each unique single cell's heavy and light chains that define each specific antibody.", "In another embodiment, sequences encoding T cell receptor components may be targeted and sequenced.", "See (Embleton et al.", "(1992) Nucleic Acids Res.", "20(15):3831; Chapal et al.", "(1997) Biotechniques 23(3):518).", "In yet other embodiments, annealing primers are selected for analyzing small nucleotide polymorphisms (SNPs), and for long range haplotyping (Zhang et al., “Long-range polony haplotyping of individual human chromosome molecules,” Nat Genet.", "2006 March; 38(3):382-7).", "These approaches provide specific information for each cell in multiple-cell biological samples.", "In certain immune related examples, bar-coding is not necessary if one uses strategies to attach the heavy and light chain prior to PCR or cleavage of the molecules from the beads, such as ligation, of CRE-LOX coupling or fragments of each unique bead, as described by Embleton et al.", "(1992) Nucleic Acids Res.", "20(15):3831; Chapal et al.", "(1997) Biotechniques 23(3):518, but in such way that many single cell at once can be treated as described in the current invention.", "As used herein, the term “barcode” refers to a unique oligonucleotide sequence that allows a corresponding nucleic acid base and/or nucleic acid sequence to be identified.", "In certain aspects, the nucleic acid base and/or nucleic acid sequence is located at a specific position on a larger polynucleotide sequence (e.g., a polynucleotide covalently attached to a bead).", "In certain embodiments, barcodes can each have a length within a range of from 4 to 36 nucleotides, or from 6 to 30 nucleotides, or from 8 to 20 nucleotides.", "In certain aspects, the melting temperatures of barcodes within a set are within 10° C. of one another, within 5° C. of one another, or within 2° C. of one another.", "In other aspects, barcodes are members of a minimally cross-hybridizing set.", "That is, the nucleotide sequence of each member of such a set is sufficiently different from that of every other member of the set that no member can form a stable duplex with the complement of any other member under stringent hybridization conditions.", "In one aspect, the nucleotide sequence of each member of a minimally cross-hybridizing set differs from those of every other member by at least two nucleotides.", "Barcode technologies are known in the art and are described in Winzeler et al.", "(1999) Science 285:901; Brenner (2000) Genome Biol.", "1:1 Kumar et al.", "(2001) Nature Rev.", "2:302; Giaever et al.", "(2004) Proc.", "Natl.", "Acad.", "Sci.", "USA 101:793; Eason et al.", "(2004) Proc.", "Natl.", "Acad.", "Sci.", "USA 101:11046; and Brenner (2004) Genome Biol.", "5:240.“Complementary” or “substantially complementary” refers to the hybridization or base pairing or the formation of a duplex between nucleotides or nucleic acids, such as, for instance, between the two strands of a double stranded DNA molecule or between an oligonucleotide primer and a primer binding site on a single stranded nucleic acid.", "Complementary nucleotides are, generally, A and T/U, or C and G. Two single-stranded RNA or DNA molecules are said to be substantially complementary when the nucleotides of one strand, optimally aligned and compared and with appropriate nucleotide insertions or deletions, pair with at least about 80% of the nucleotides of the other strand, usually at least about 90% to 95%, and more preferably from about 98 to 100%.", "Alternatively, substantial complementarity exists when an RNA or DNA strand will hybridize under selective hybridization conditions to its complement.", "Typically, selective hybridization will occur when there is at least about 65% complementary over a stretch of at least 14 to 25 nucleotides, at least about 75%, or at least about 90% complementary.", "See Kanehisa (1984) Nucl.", "Acids Res.", "12:203.As used herein, the term “hybridization” refers to the process in which two single-stranded polynucleotides bind non-covalently to form a stable double-stranded polynucleotide.", "The term “hybridization” may also refer to triple-stranded hybridization.", "The resulting (usually) double-stranded polynucleotide is a “hybrid” or “duplex.” “Hybridization conditions” will typically include salt concentrations of less than about 1 M, more usually less than about 500 mM and even more usually less than about 200 mM.", "Hybridization temperatures can be as low as 5° C., but are typically greater than 22° C., more typically greater than about 30° C., and often in excess of about 37° C. Hybridizations are usually performed under stringent conditions, i.e., conditions under which a probe will hybridize to its target subsequence.", "Stringent conditions are sequence-dependent and are different in different circumstances.", "Longer fragments may require higher hybridization temperatures for specific hybridization.", "As other factors may affect the stringency of hybridization, including base composition and length of the complementary strands, presence of organic solvents and extent of base mismatching, the combination of parameters is more important than the absolute measure of any one alone.", "Generally, stringent conditions are selected to be about 5° C. lower than the Tm for the specific sequence at s defined ionic strength and pH.", "Exemplary stringent conditions include salt concentration of at least 0.01 M to no more than 1 M Na ion concentration (or other salts) at a pH 7.0 to 8.3 and a temperature of at least 25° C. For example, conditions of 5×SSPE (750 mM NaCl, 50 mM Na phosphate, 5 mM EDTA, pH 7.4) and a temperature of 25-30° C. are suitable for allele-specific probe hybridizations.", "For stringent conditions, see for example, Sambrook, Fritsche and Maniatis, Molecular Cloning A Laboratory Manual, 2nd Ed.", "Cold Spring Harbor Press (1989) and Anderson Nucleic Acid Hybridization, 1st Ed., BIOS Scientific Publishers Limited (1999).", "“Hybridizing specifically to” or “specifically hybridizing to” or like expressions refer to the binding, duplexing, or hybridizing of a molecule substantially to or only to a particular nucleotide sequence or sequences under stringent conditions when that sequence is present in a complex mixture (e.g., total cellular) DNA or RNA.", "“Nucleoside” as used herein includes the natural nucleosides, including 2′-deoxy and 2′-hydroxyl forms, e.g.", "as described in Komberg and Baker, DNA Replication, 2nd Ed.", "(Freeman, San Francisco, 1992).", "“Analogs” in reference to nucleosides includes synthetic nucleosides having modified base moieties and/or modified sugar moieties, e.g., described by Scheit, Nucleotide Analogs (John Wiley, New York, 1980); Uhlman and Peyman, Chemical Reviews, 90:543-584 (1990), or the like, with the proviso that they are capable of specific hybridization.", "Such analogs include synthetic nucleosides designed to enhance binding properties, reduce complexity, increase specificity, and the like.", "Polynucleotides comprising analogs with enhanced hybridization or nuclease resistance properties are described in Uhlman and Peyman (cited above); Crooke et al., Exp.", "Opin.", "Ther.", "Patents, 6: 855-870 (1996); Mesmaeker et al., Current Opinion in Structural Biology, 5:343-355 (1995); and the like.", "Exemplary types of polynucleotides that are capable of enhancing duplex stability include oligonucleotide phosphoramidates (referred to herein as “amidates”), peptide nucleic acids (referred to herein as “PNAs”), oligo-2′-O-alkylribonucleotides, polynucleotides containing C-5 propynylpyrimidines, locked nucleic acids (LNAs), and like compounds.", "Such oligonucleotides are either available commercially or may be synthesized using methods described in the literature.", "As used herein, the terms “nucleic acid molecule,” “nucleic acid sequence,” “nucleic acid fragment,” “oligonucleotide,” “oligonucleotide fragment” and “polynucleotide” are used interchangeably and are intended to include, but are not limited to, a polymeric form of nucleotides that may have various lengths, either deoxyribonucleotides or ribonucleotides, or analogs thereof.", "Nucleic acid molecules include single stranded DNA (ssDNA), double stranded DNA (dsDNA), single stranded RNA (ssRNA) and double stranded RNA (dsRNA).", "Different nucleic acid molecules may have different three-dimensional structures, and may perform various functions, known or unknown.", "Non-limiting examples of nucleic acid molecules include a gene, a gene fragment, a genomic gap, an exon, an intron, intergenic DNA (including, without limitation, heterochromatic DNA), messenger RNA (mRNA), transfer RNA, ribosomal RNA, ribozymes, small interfering RNA (siRNA), miRNA, small nucleolar RNA (snoRNA), cDNA, recombinant polynucleotides, branched polynucleotides, plasmids, vectors, isolated DNA of a sequence, isolated RNA of a sequence, nucleic acid probes, and primers.", "Nucleic acid molecules useful in the methods described herein may comprise natural nucleic acid sequences and variants thereof, artificial nucleic acid sequences, or a combination of such sequences.", "An oligonucleotide sequence refers to a linear polymer of natural or modified nucleosidic monomers linked by phosphodiester bonds or analogs thereof.", "The term “oligonucleotide” usually refers to a shorter polymer, e.g., comprising from about 3 to about 100 monomers, and the term “polynucleotide” usually refers to longer polymers, e.g., comprising from about 100 monomers to many thousands of monomers, e.g., 10,000 monomers, or more An “oligonucleotide fragment” refers to an oligonucleotide sequence that has been cleaved into two or more smaller oligonucleotide sequences.", "Oligonucleotides comprising probes or primers usually have lengths in the range of from 12 to 60 nucleotides, and more usually, from 18 to 40 nucleotides.", "Oligonucleotides and polynucleotides may be natural or synthetic.", "Oligonucleotides and polynucleotides include deoxyribonucleosides, ribonucleosides, and non-natural analogs thereof, such as anomeric forms thereof, peptide nucleic acids (PNAs), and the like, provided that they are capable of specifically binding to a target genome by way of a regular pattern of monomer-to-monomer interactions, such as Watson-Crick type of base pairing, base stacking, Hoogsteen or reverse Hoogsteen types of base pairing, or the like.", "Usually nucleosidic monomers are linked by phosphodiester bonds.", "Whenever an oligonucleotide is represented by a sequence of letters, such as “ATGCCTG,” it will be understood that the nucleotides are in 5′ to 3′ order from left to right and that “A” denotes deoxyadenosine, “C” denotes deoxycytidine, “G” denotes deoxyguanosine, “T” denotes deoxythymidine, and “U” denotes the ribonucleoside, uridine, unless otherwise noted.", "Usually oligonucleotides comprise the four natural deoxynucleotides; however, they may also comprise ribonucleosides or non-natural nucleotide analogs.", "It is clear to those skilled in the art when oligonucleotides having natural or non-natural nucleotides may be employed in methods and processes described herein.", "For example, where processing by an enzyme is called for, usually oligonucleotides consisting solely of natural nucleotides are required.", "Likewise, where an enzyme has specific oligonucleotide or polynucleotide substrate requirements for activity, e.g., single stranded DNA, RNA/DNA duplex, or the like, then selection of appropriate composition for the oligonucleotide or polynucleotide substrates is well within the knowledge of one of ordinary skill, especially with guidance from treatises, such as Sambrook et al., Molecular Cloning, Second Edition (Cold Spring Harbor Laboratory, New York, 1989), and like references.", "Oligonucleotides and polynucleotides may be single stranded or double stranded.", "Nucleic acid molecules may optionally include one or more non-standard nucleotide(s), nucleotide analog(s) and/or modified nucleotides.", "Examples of modified nucleotides include, but are not limited to diaminopurine, S2T, 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xantine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl)uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-D46-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, 2,6-diaminopurine and the like.", "Nucleic acid molecules may also be modified at the base moiety (e.g., at one or more atoms that typically are available to form a hydrogen bond with a complementary nucleotide and/or at one or more atoms that are not typically capable of forming a hydrogen bond with a complementary nucleotide), sugar moiety or phosphate backbone.", "In certain exemplary embodiments, large polynucleotides are provided.", "In certain aspects, isolation techniques that maximize the lengths of polynucleotides (e.g., DNA molecules) obtained are used.", "For example, in situ lysis or deproteinization (e.g., with EDTA, detergent, protease, any combinations thereof and the like) after agarose embedding (as routinely performed for pulsed field gel electrophoresis) can be used to obtain polynucleotides.", "Nucleic acid molecules may be isolated from natural sources or purchased from commercial sources.", "Oligonucleotide sequences may also be prepared by any suitable method, e.g., standard phosphoramidite methods such as those described by Beaucage and Carruthers ((1981) Tetrahedron Lett.", "22: 1859) or the triester method according to Matteucci et al.", "(1981) J.", "Am.", "Chem.", "Soc.", "103:3185), or by other chemical methods using either a commercial automated oligonucleotide synthesizer or high-throughput, high-density array methods known in the art (see U.S. Pat.", "Nos.", "5,602,244, 5,574,146, 5,554,744, 5,428,148, 5,264,566, 5,141,813, 5,959,463, 4,861,571 and 4,659,774, incorporated herein by reference in its entirety for all purposes).", "Pre-synthesized oligonucleotides may also be obtained commercially from a variety of vendors.", "Nucleic acid molecules may be obtained from one or more biological samples.", "As used herein, a “biological sample” may be a single cell or many cells.", "A biological sample may comprise a single cell type or a combination of two or more cell types.", "A biological sample further includes a collection of cells that perform a similar function such as those found, for example, in a tissue.", "Accordingly, certain aspects of the invention are directed to biological samples containing one or more tissues.", "As used herein, a tissue includes, but is not limited to, epithelial tissue (e.g., skin, the lining of glands, bowel, skin and organs such as the liver, lung, kidney), endothelium (e.g., the lining of blood and lymphatic vessels), mesothelium (e.g., the lining of pleural, peritoneal and pericardial spaces), mesenchyme (e.g., cells filling the spaces between the organs, including fat, muscle, bone, cartilage and tendon cells), blood cells (e.g.", "erythrocytes, granulocytes, neutrophils, eosinophils, basophils, monocytes, T-lymphocytes (also known as T-cells), B-lymphocytes (also known as B-cells), plasma cells, megakaryocytes and the like), neurons, germ cells (e.g., spermatozoa, oocytes), amniotic fluid cells, placenta, stem cells and the like.", "A tissue sample includes microscopic samples as well as macroscopic samples.", "In certain aspects, a sample can be obtained from one or more of single cells in culture, metagenomic samples, embryonic stem cells, induced pluripotent stem cells, cancer samples, tissue sections, biopsies and the like, and any combinations of these.", "In certain aspects, nucleic acid sequences derived or obtained from one or more organisms are provided.", "As used herein, the term “organism” includes, but is not limited to, a human, a non-human primate, a cow, a horse, a sheep, a goat, a pig, a dog, a cat, a rabbit, a mouse, a rat, a gerbil, a frog, a toad, a fish (e.g., Danio rerio) a roundworm (e.g., C. elegans) and any transgenic species thereof.", "The term “organism” further includes, but is not limited to, a yeast (e.g., S. cerevisiae) cell, a yeast tetrad, a yeast colony, a bacterium, a bacterial colony, a virion, virosome, virus-like particle and/or cultures thereof, and the like.", "Isolation, extraction or derivation of nucleic acid sequences may be carried out by any suitable method.", "Isolating nucleic acid sequences from a biological sample generally includes treating a biological sample in such a manner that nucleic acid sequences present in the sample are extracted and made available for analysis.", "Any isolation method that results in extracted nucleic acid sequences may be used in the practice of the present invention.", "It will be understood that the particular method used to extract nucleic acid sequences will depend on the nature of the source.", "Methods of DNA extraction are well-known in the art.", "A classical DNA isolation protocol is based on extraction using organic solvents such as a mixture of phenol and chloroform, followed by precipitation with ethanol (J. Sambrook et al., “Molecular Cloning: A Laboratory Manual,” 1989, 2nd Ed., Cold Spring Harbour Laboratory Press: New York, N.Y.).", "Other methods include: salting out DNA extraction (P. Sunnucks et al., Genetics, 1996, 144: 747-756; S. M. Aljanabi and I. Martinez, Nucl.", "Acids Res.", "1997, 25: 4692-4693), trimethylammonium bromide salts DNA extraction (S. Gustincich et al., BioTechniques, 1991, 11: 298-302) and guanidinium thiocyanate DNA extraction (J.", "B. W. Hammond et al., Biochemistry, 1996, 240: 298-300).", "A variety of kits are commercially available for extracting DNA from biological samples (e.g., BD Biosciences Clontech (Palo Alto, Calif.): Epicentre Technologies (Madison, Wis.); Gentra Systems, Inc. (Minneapolis, Minn.); MicroProbe Corp. (Bothell, Wash.); Organon Teknika (Durham, N.C.); and Qiagen Inc. (Valencia, Calif.)).", "Methods of RNA extraction are also well known in the art (see, for example, J. Sambrook et al., “Molecular Cloning: A Laboratory Manual” 1989, 2nd Ed., Cold Spring Harbour Laboratory Press: New York) and several kits for RNA extraction from bodily fluids are commercially available (e.g., Ambion, Inc. (Austin, Tex.", "); Amersham Biosciences (Piscataway, N.J.); BD Biosciences Clontech (Palo Alto, Calif.); BioRad Laboratories (Hercules, Calif.); Dynal Biotech Inc. (Lake Success, N.Y.); Epicentre Technologies (Madison, Wis.); Gentra Systems, Inc. (Minneapolis, Minn.); GIBCO BRL (Gaithersburg, Md.", "); Invitrogen Life Technologies (Carlsbad, Calif.); MicroProbe Corp. (Bothell, Wash.); Organon Teknika (Durham, N.C.); Promega, Inc. (Madison, Wis.); and Qiagen Inc. (Valencia, Calif.)).", "In certain exemplary embodiments, oligonucleotide sequences are immobilized on a solid support.", "The support can be simple square grids, checkerboard (e.g., offset) grids, hexagonal arrays and the like.", "Suitable supports include, but are not limited to, slides, beads, chips, particles, strands, gels, sheets, tubing, spheres, containers, capillaries, pads, slices, films, culture dishes, plates (e.g., 96-well, 48-well, 24-well, 12-well, eight-well, six-well, four-well, single-well and the like), cell surfaces (e.g., S. aureus cells) and the like.", "In various embodiments, a solid support may be biological, non-biological, organic, inorganic, or any combination thereof.", "In certain exemplary embodiments, beads and bead-based arrays are provided.", "As used herein, the term “bead” refers to a discrete particle that may be spherical (e.g., microspheres) or have an irregular shape.", "Beads may be as small as approximately 0.1 μm in diameter or as large approximately several millimeters in diameter.", "Beads may comprise a variety of materials including, but not limited to, paramagnetic materials, ceramic, plastic, glass, polystyrene, methylstyrene, acrylic polymers, titanium, latex, sepharose, cellulose, nylon and the like.", "In accordance with certain examples, a support (e.g., a bead) may have functional groups attached to its surface which can be used to bind one or more reagents described herein to the bead.", "One or more reagents can be attached to a support (e.g., a bead) by hybridization, covalent attachment, magnetic attachment, affinity attachment and the like.", "Beads coated with a variety of attachments are commercially available (Dynabeads, Invitrogen).", "Supports (e.g., beads) may also be functionalized using, for example, solid-phase chemistries known in the art (see, e.g., U.S. Pat.", "No.", "5,919,523).", "As used herein, the term “attach” refers to both covalent interactions and noncovalent interactions.", "A covalent interaction is a chemical linkage between two atoms or radicals formed by the sharing of a pair of electrons (i.e., a single bond), two pairs of electrons (i.e., a double bond) or three pairs of electrons (i.e., a triple bond).", "Covalent interactions are also known in the art as electron pair interactions or electron pair bonds.", "Noncovalent interactions include, but are not limited to, van der Waals interactions, hydrogen bonds, weak chemical bonds (i.e., via short-range noncovalent forces), hydrophobic interactions, ionic bonds and the like.", "A review of noncovalent interactions can be found in Alberts et al., in Molecular Biology of the Cell, 3d edition, Garland Publishing, 1994.In certain exemplary embodiments, methods for amplifying nucleic acid sequences are provided.", "Exemplary methods for amplifying nucleic acids include the polymerase chain reaction (PCR) (see, e.g., Mullis et al.", "(1986) Cold Spring Harb.", "Symp.", "Quant.", "Biol.", "51 Pt 1:263 and Cleary et al.", "(2004) Nature Methods 1:241; and U.S. Pat.", "Nos.", "4,683,195 and 4,683,202), anchor PCR, RACE PCR, ligation chain reaction (LCR) (see, e.g., Landegran et al.", "(1988) Science 241:1077-1080; and Nakazawa et al.", "(1994) Proc.", "Natl.", "Acad.", "Sci.", "U.S.A. 91:360-364), self sustained sequence replication (Guatelli et al.", "(1990) Proc.", "Natl.", "Acad.", "Sci.", "U.S.A. 87:1874), transcriptional amplification system (Kwoh et al.", "(1989) Proc.", "Natl.", "Acad.", "Sci.", "U.S.A. 86:1173), Q-Beta Replicase (Lizardi et al.", "(1988) BioTechnology 6:1197), recursive PCR (Jaffe et al.", "(2000) J. Biol.", "Chem.", "275:2619; and Williams et al.", "(2002) J. Biol.", "Chem.", "277:7790), the amplification methods described in U.S. Pat.", "Nos.", "6,391,544, 6,365,375, 6,294,323, 6,261,797, 6,124,090 and 5,612,199, isothermal amplification (e.g., rolling circle amplification (RCA), hyperbranched rolling circle amplification (HRCA), strand displacement amplification (SDA), helicase-dependent amplification (HDA), PWGA) or any other nucleic acid amplification method using techniques well known to those of skill in the art.", "“Polymerase chain reaction,” or “PCR,” refers to a reaction for the in vitro amplification of specific DNA sequences by the simultaneous primer extension of complementary strands of DNA.", "In other words, PCR is a reaction for making multiple copies or replicates of a target nucleic acid flanked by primer binding sites, such reaction comprising one or more repetitions of the following steps: (i) denaturing the target nucleic acid, (ii) annealing primers to the primer binding sites, and (iii) extending the primers by a nucleic acid polymerase in the presence of nucleoside triphosphates.", "Usually, the reaction is cycled through different temperatures optimized for each step in a thermal cycler instrument.", "Particular temperatures, durations at each step, and rates of change between steps depend on many factors well-known to those of ordinary skill in the art, e.g., exemplified by the references: McPherson et al., editors, PCR: A Practical Approach and PCR2: A Practical Approach (IRL Press, Oxford, 1991 and 1995, respectively).", "For example, in a conventional PCR using Taq DNA polymerase, a double stranded target nucleic acid may be denatured at a temperature greater than 90° C., primers annealed at a temperature in the range 50-75° C., and primers extended at a temperature in the range 72-78° C. The term “PCR” encompasses derivative forms of the reaction, including but not limited to, RT-PCR, real-time PCR, nested PCR, quantitative PCR, multiplexed PCR, assembly PCR and the like.", "Reaction volumes range from a few hundred nanoliters, e.g., 200 nL, to a few hundred microliters, e.g., 200 microliters.", "“Reverse transcription PCR,” or “RT-PCR,” means a PCR that is preceded by a reverse transcription reaction that converts a target RNA to a complementary single stranded DNA, which is then amplified, e.g., Tecott et al., U.S. Pat.", "No.", "5,168,038.“Real-time PCR” means a PCR for which the amount of reaction product, i.e., amplicon, is monitored as the reaction proceeds.", "There are many forms of real-time PCR that differ mainly in the detection chemistries used for monitoring the reaction product, e.g., Gelfand et al., U.S. Pat.", "No.", "5,210,015 (“Taqman”); Wittwer et al., U.S. Pat.", "Nos.", "6,174,670 and 6,569,627 (intercalating dyes); Tyagi et al., U.S. Pat.", "No.", "5,925,517 (molecular beacons).", "Detection chemistries for real-time PCR are reviewed in Mackay et al., Nucleic Acids Research, 30:1292-1305 (2002).", "“Nested PCR” means a two-stage PCR wherein the amplicon of a first PCR becomes the sample for a second PCR using a new set of primers, at least one of which binds to an interior location of the first amplicon.", "As used herein, “initial primers” in reference to a nested amplification reaction mean the primers used to generate a first amplicon, and “secondary primers” mean the one or more primers used to generate a second, or nested, amplicon.", "“Multiplexed PCR” means a PCR wherein multiple target sequences (or a single target sequence and one or more reference sequences) are simultaneously carried out in the same reaction mixture, e.g.", "Bernard et al.", "(1999) Anal.", "Biochem., 273:221-228 (two-color real-time PCR).", "Usually, distinct sets of primers are employed for each sequence being amplified.", "“Quantitative PCR” means a PCR designed to measure the abundance of one or more specific target sequences in a sample or specimen.", "Techniques for quantitative PCR are well-known to those of ordinary skill in the art, as exemplified in the following references: Freeman et al., Biotechniques, 26:112-126 (1999); Becker-Andre et al., Nucleic Acids Research, 17:9437-9447 (1989); Zimmerman et al., Biotechniques, 21:268-279 (1996); Diviacco et al., Gene, 122:3013-3020 (1992); Becker-Andre et al., Nucleic Acids Research, 17:9437-9446 (1989); and the like.", "In certain exemplary embodiments, methods of determining the sequence identities of nucleic acid sequences are provided.", "Determination of the sequence of a nucleic acid sequence of interest (e.g., immune cell nucleic acid sequences) can be performed using variety of sequencing methods known in the art including, but not limited to, sequencing by hybridization (SBH), sequencing by ligation (SBL), quantitative incremental fluorescent nucleotide addition sequencing (QIFNAS), stepwise ligation and cleavage, fluorescence resonance energy transfer (FRET), molecular beacons, TaqMan reporter probe digestion, pyrosequencing, fluorescent in situ sequencing (FISSEQ), FISSEQ beads (U.S. Pat.", "No.", "7,425,431), wobble sequencing (PCT/US05/27695), multiplex sequencing (U.S. Ser.", "No.", "12/027,039, filed Feb. 6, 2008; Porreca et al (2007) Nat.", "Methods 4:931), polymerized colony (POLONY) sequencing (U.S. Pat.", "Nos.", "6,432,360, 6,485,944 and 6,511,803, and PCT/US05/06425); nanogrid rolling circle sequencing (ROLONY) (U.S. Ser.", "No.", "12/120,541, filed May 14, 2008), allele-specific oligo ligation assays (e.g., oligo ligation assay (OLA), single template molecule OLA using a ligated linear probe and a rolling circle amplification (RCA) readout, ligated padlock probes, and/or single template molecule OLA using a ligated circular padlock probe and a rolling circle amplification (RCA) readout) and the like.", "High-throughput sequencing methods, e.g., on cyclic array sequencing using platforms such as Roche 454, Illumina Solexa, ABI-SOLiD, ION Torrents, Complete Genomics, Pacific Bioscience, Helicos, Polonator platforms (Worldwide Web Site: Polonator.org), and the like, can also be utilized.", "High-throughput sequencing methods are described in U.S. Ser.", "No.", "61/162,913, filed Mar.", "24, 2009.A variety of light-based sequencing technologies are known in the art (Landegren et al.", "(1998) Genome Res.", "8:769-76; Kwok (2000) Pharmocogenomics 1:95-100; and Shi (2001) Clin.", "Chem.", "47:164-172).", "In certain exemplary embodiments, methods of prognosing, diagnosing and/or monitoring one or more disorders or diseases associated with an infectious agent are provided.", "Infectious agents include, but are not limited to, viruses, bacteria, fungi, parasites, infectious proteins and the like.", "Viruses include, but are not limited to, DNA or RNA animal viruses.", "As used herein, RNA viruses include, but are not limited to, virus families such as Picornaviridae (e.g., polioviruses), Reoviridae (e.g., rotaviruses), Togaviridae (e.g., encephalitis viruses, yellow fever virus, rubella virus), Orthomyxoviridae (e.g., influenza viruses), Paramyxoviridae (e.g., respiratory syncytial virus, measles virus, mumps virus, parainfluenza virus), Rhabdoviridae (e.g., rabies virus), Coronaviridae, Bunyaviridae, Flaviviridae, Filoviridae, Arenaviridae, Bunyaviridae and Retroviridae (e.g., human T cell lymphotropic viruses (HTLV), human immunodeficiency viruses (HIV)).", "As used herein, DNA viruses include, but are not limited to, virus families such as Papovaviridae (e.g., papilloma viruses), Adenoviridae (e.g., adenovirus), Herpesviridae (e.g., herpes simplex viruses), and Poxviridae (e.g., variola viruses).", "Bacteria include, but are not limited to, gram positive bacteria, gram negative bacteria, acid-fast bacteria and the like.", "As used herein, gram positive bacteria include, but are not limited to, Actinomedurae, Actinomyces israelii, Bacillus anthracis, Bacillus cereus, Clostridium botulinum, Clostridium difficile, Clostridium perfringens, Clostridium tetani, Corynebacterium, Enterococcus faecalis, Listeria monocytogenes, Nocardia, Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epiderm, Streptococcus mutans, Streptococcus pneumoniae and the like.", "As used herein, gram negative bacteria include, but are not limited to, Afipia felis, Bacteroides, Bartonella bacilliformis, Bortadella pertussis, Borrelia burgdorferi, Borrelia recurrentis, Brucella, Calymmatobacterium granulomatis, Campylobacter, Escherichia coli, Francisella tularensis, Gardnerella vaginalis, Haemophilius aegyptius, Haemophilius ducreyi, Haemophilius influenziae, Heliobacter pylori, Legionella pneumophila, Leptospira interrogans, Neisseria meningitidia, Porphyromonas gingivalis, Providencia sturti, Pseudomonas aeruginosa, Salmonella enteridis, Salmonella typhi, Serratia marcescens, Shigella boydii, Streptobacillus moniliformis, Streptococcus pyogenes, Treponema pallidum, Vibrio cholerae, Yersinia enterocolitica, Yersinia pestis and the like.", "As used herein, acid-fast bacteria include, but are not limited to, Myobacterium avium, Myobacterium leprae, Myobacterium tuberculosis and the like.", "As used herein, other bacteria not falling into the other three categories include, but are not limited to, Bartonella henseiae, Chlamydia psittaci, Chlamydia trachomatis, Coxiella burnetii, Mycoplasma pneumoniae, Rickettsia akari, Rickettsia prowazekii, Rickettsia rickettsii, Rickettsia tsutsugamushi, Rickettsia typhi, Ureaplasma urealyticum, Diplococcus pneumoniae, Ehrlichia chafensis, Enterococcus faecium, Meningococci and the like.", "As used herein, fungi include, but are not limited to, Aspergilli, Candidae, Candida albicans, Coccidioides immitis, Cryptococci, and combinations thereof.", "As used herein, parasitic microbes include, but are not limited to, Balantidium coli, Cryptosporidium parvum, Cyclospora cayatanensis, Encephalitozoa, Entamoeba histolytica, Enterocytozoon bieneusi, Giardia lamblia, Leishmaniae, Plasmodii, Toxoplasma gondii, Trypanosomae, trapezoidal amoeba and the like.", "As used herein, parasites include worms (e.g., helminthes), particularly parasitic worms including, but not limited to, Nematoda (roundworms, e.g., whipworms, hookworms, pinworms, ascarids, filarids and the like), Cestoda (e.g., tapeworms) As used herein, infectious proteins include prions.", "Disorders caused by prions include, but are not limited to, human disorders such as Creutzfeldt-Jakob disease (CJD) (including, e.g., iatrogenic Creutzfeldt-Jakob disease (iCJD), variant Creutzfeldt-Jakob disease (vCJD), familial Creutzfeldt-Jakob disease (fCJD), and sporadic Creutzfeldt-Jakob disease (sCJD)), Gerstmann-Sträussler-Scheinker syndrome (GSS), fatal familial insomnia (WI), sporadic fatal insomnia (sFI), kuru, and the like, as well as disorders in animals such as scrapie (sheep and goats), bovine spongiform encephalopathy (BSE) (cattle), transmissible mink encephalopathy (TME) (mink), chronic wasting disease (CWD) (elk, mule deer), feline spongiform encephalopathy (cats), exotic ungulate encephalopathy (EUE) (nyala, oryx, greater kudu), spongiform encephalopathy of the ostrich and the like.", "In certain exemplary embodiments, methods of prognosing, diagnosing and/or monitoring one or more cellular proliferative disorders are provided.", "Cellular proliferative disorders are intended to include disorders associated with rapid proliferation.", "As used herein, the term “cellular proliferative disorder” includes disorders characterized by undesirable or inappropriate proliferation of one or more subset(s) of cells in a multicellular organism.", "The term “cancer” refers to various types of malignant neoplasms, most of which can invade surrounding tissues, and may metastasize to different sites (see, for example, PDR Medical Dictionary 1st edition (1995), incorporated herein by reference in its entirety for all purposes).", "The terms “neoplasm” and “tumor” refer to an abnormal tissue that grows by cellular proliferation more rapidly than normal.", "Id.", "Such abnormal tissue shows partial or complete lack of structural organization and functional coordination with the normal tissue which may be either benign (i.e., benign tumor) or malignant (i.e., malignant tumor).", "The language “treatment of cellular proliferative disorders” is intended to include the prevention of the induction, onset, establishment or growth of neoplasms in a subject or a reduction in the growth of pre-existing neoplasms in a subject.", "The language also can describe inhibition of the invasion of neoplastic cells into neighboring tissues or the metastasis of a neoplasm from one site to another.", "Examples of the types of neoplasms intended to be encompassed by the present invention include but are not limited to those neoplasms associated with cancers of the breast, skin, bone, prostate, ovaries, uterus, cervix, liver, lung, brain, larynx, gallbladder, pancreas, rectum, parathyroid, thyroid, adrenal gland, immune system, neural tissue, head and neck, colon, stomach, bronchi, and/or kidneys.", "Cellular proliferative disorders can further include disorders associated with hyperproliferation of vascular smooth muscle cells such as proliferative cardiovascular disorders, e.g., atherosclerosis and restenosis.", "Cellular proliferation disorders can also include disorders such as proliferative skin disorders, e.g., X-linked ichthyosis, psoriasis, atopic dermatitis, allergic contact dermatitis, epidermolytic hyperkeratosis, and seborrheic dermatitis.", "Cellular proliferative disorders can further include disorders such as autosomal dominant polycystic kidney disease (ADPKD), mastocystosis, and cellular proliferation disorders caused by infectious agents such as viruses.", "In certain exemplary embodiments, methods of prognosing, diagnosing and/or monitoring one or more autoimmune disorders are provided.", "As used herein, the term “autoimmune disorder” is a disease or disorder caused by a subject producing an inappropriate immune response against its own tissues.", "As used herein, an autoimmune disorder includes, but is not limited to, disorders such as Addison's disease, alopecia areata, ankylosing spondylitis, antiphospholipid sundrome, autoimmune hemolytic anemia, autoimmune hepatitis, autoimmune inner ear disease (AIED), autoimmune lymphoproliferative syndrome (ALPS), autoimmune thrombocytopenic purpura (ATP), Balo disease, Bechet disease, bullous pemphigoid, cardiomyopathy, celiac sprue-dermatitis herpetiformis, chronic fatigue immune dysfunction syndrome (CFIDS), chronic inflammatory demyelinating polyneuropathy, cicatricial pemphigoid, cold agglutinin disease, CREST syndrome, Crohn's disease, Degos disease, dermatomyositis, dermatomyositis-juvenile, discoid lupus, essential mixed cryoglobulinemia, fibromyalgia-fibromyositis, Graves disease, Guillain-Barré, Hashimoto thyroiditis, idiopathic pulmonary fibrosis, idiopathic thrombocytopenia purpura (ITP), IgA nephropathy, insulin-dependent diabetes, juvenile arthritis, lichen planus, lupus, Ménière disease, mixed connective tissue disease, multiple sclerosis, myasthemia gravis, pemphigus vulgaris, pernicious anemia, polyarteritis nodosa, polychondritis, polyglandular syndromes, polymyalgia rheumatica, polymyositis and dermatomyositis, primary agammaglobulinemia, primary biliary cirrhosis, psoriasis, Raynaud phenomenon, Reiter syndrome, rheumatic fever, rheumatoid arthritis, sarcoidosis, scleroderma, Sjögren syndrome, stiff-person syndrome, Takayasu arthritis, temporal arteritis/giant cell arteritis, ulcerative colitis, vasculitis, vitiligo, Wegener granulomatosis and the like (See the American Autoimmune Related Diseases Association, Inc. website: aarda.org).", "It is to be understood that the embodiments of the present invention which have been described are merely illustrative of some of the applications of the principles of the present invention.", "Numerous modifications may be made by those skilled in the art based upon the teachings presented herein without departing from the true spirit and scope of the invention.", "The contents of all references, patents and published patent applications cited throughout this application are hereby incorporated by reference in their entirety for all purposes.", "Example 1 Preparing Bar-Coded Beads a. Loading the Template Bar-Code Oligonucleotide onto Beads Beads (1 μM; C1 carboxylic 1 micron beads) were resuspended by vortexing and transferred in a volume of 80 μl to a 1.5 ml silicon tube (Ambion).", "The beads were washed twice with 2× (Bind and Wash Buffer contains 10 mM Tris-HCl ph7.5, 1 mM EDTA, 2M NaCl; “B&W”).", "Beads were isolated using magnets between washes.", "Nucleotide sequences are listed in Table 4.The washed beads were resuspended in 100 μl B&W to which oligo dT bar-code template oligonucleotide (HSCT_BC_anchor1) were added at the concentrations as shown in Table 1.TABLE 1 Primer Stock Primer Tube Concentration volume (μl) 1 100 pM 80 2 10 pM 80 3 1 pM 80 4 0.1 pN 80 The template oligonucleotide and beads were incubated on a rotator for 20 minutes, then washed twice with 200 μl of 1× B&W then resuspended in 100 μl of 2× B&W.", "b. Saturating the Beads with Anchor Primer The beads, pre-loaded with the template oligonucleotide as in Example 1(a) above, were incubated on a rotator for 20 minutes with Anchor primer mix (1 mM HSCT_Bead_anchor1 and 1× B&W buffer) to coat the beads with the anchor primer then washed twice with 200 μl of 1× B&W, once in 200 μl of TE, then resuspended in 100 μl of TE.", "The anchor primer has a 5′ biotin which binds to the streptavidin coated beads.", "Typically, 30% of the beads have an oligonucleotide.", "On those beads 100% or substantially all of the anchor primers are typically extended.", "c. Emulsion PCR to Synthesis the Oligonucleotide from the Anchor Primer Aqueous Mix and Oil Mix were prepared as described in Table 2.TABLE 2 Volume for 1 Volume for Component tube (μl) 4.5 tubes (μl) AQUEOUS MIX 10 x PCR 96 432 buffer (Enymatics) 50 mM 242 1,089 MgCl2 25 mM 135 607 dNTP mix 2 mM 6 27 HSCT_dA- rev_emulsion primer OIL MIX Tegosoft 4.4 19.8 DEC Mineral oil 1.2 5.4 ABIL WE09 425 1.9 Both solutions are mixed by vortexing.", "The oil mix is allowed to degass then 5.5 ml portions were placed in 50 ml Teflon-coated aluminum test tubes.", "The emulsions were made by adding 800 μl PCR mix, 100 μl Enzymatics Taq (5 U/μl), quickly vortexing and spinning, then immediately adding 60 ml of bar-code anchored beads, followed by vortex and spinning.", "The 960 ml mix was transferred to a tube of oil and vortexed for 2.25 min at 2200 rpm, which was followed by emulsion PCR using the following PCR protocol steps: b.", "94° C. for 5 min c. 94° C. for 15 sec d. 58° C. for 30 sec e. 70° C. for 75 sec f. Cycle to step b 119 times g. 72° C. for 2 min h. Incubate at −10° C. until ready to use.", "Formation of an emulsion was confirmed by verifying under a microscope that a creamy white consistency was obtained when an emulsifier/oil mixture (240 μl emulsifier: 960 μl oil, or 480 μl emulsifier: 720 μl oil) was added to an aqueous layer (384 μl) and vortexed at 4° C. for 5 minutes.", "Results are show in FIGS.", "7A-7E.", "In a similar experiment, Dynal M270 3-micron beads were used under similar conditions and similar results were achieved.", "Bar-coding was also achieved as follows.", "TABLE 3 AQUEOUS MIX Final Volume per Component concentration tube (μl) dH20 — 520.4 10 x PCR 1x 80 buffer (Enymatics) 25 mM 2 mM 64 dNTP mix 2 mM 10 μM 4 HSCT_dA- rev_emulsion primer 30% (w/v) 0.06 1.6 BSA (Sigma) OIL MIX Volume for 1 Volume for Component tube (μl) 4.5 tubes (μl) Tegosoft 4.4 19.8 DEC Mineral oil 1.2 5.4 ABIL WE09 425 1.9 The aqueous mix was vortexed, then 0.6 ml of mix was added per 1.5 ml tube (Ambion; non-stick).", "50 μl of M280 HSCT Anchor bead was added per tube, then the tubes were sonicated for 3 cycles of 10 seconds.", "After sonication, the tubes were placed on ice, and 80 μl of Taq Polymerase (5 U/μl) was added per tube.", "The tubes were again vortexed and placed on ice.", "800 μl of the mixture was added to the oil phase, the tubes were vortexed and PCR was performed as described in Example 1 part c. In similar experiments 96 well/plates were used.", "Each well contained 55 μl/well of the mixture.", "SEQ Sequence ID Name NO: Sequence HSCT_BC_ 4 /52-Bio/ACA CTC TTT CCC TAC ACG anchor1 ACG CTC TTC CGA TCT NNN NNN NNN NNN NNN NNN NNC AGC TTT TTT TTT TTT TTT TTT TTT TTT T HSCT_Bead_ 5 /52-Bio/ACA CTC TTT CCC TAC ACG anchor1 ACG CTC TTC CGA TCT HSCT_ 6 /5Phos/AGA TCG GAA GAG CGT CGT clonaltest_ GTA BC_seq HSCT_dA_rev_ 7 AAA AAA AAA AAA AAA AAA AAA AAA emulsion ACG AC primer HSCT_BC_ 8 AAA AAA AAA AAA AAA AAA AAA anchor_ AAA AGC TGN NNN NNN NNN NNN rev(no-bio) NNN NNN NAG ATC GGA AGA GCG TCG TGT AGG GAA AGA GTG T Bead 9 BEAD/52- attached to Bio/ Bar-coded ACACTCTTTCCCTACACGACGCTCTTCCGATCT Oligonu- NNN NNN NNN NNN NNN NNN NNC AGC cleotide TTT TTT TTT TTT TTT TTT TTT TTT T ATGTGCTGCGAGAAGGCTAGA/5Phos/ Table 4 shows the sequences used in Example 1.The final sequence attached to the bead in Example 1 is shown in SEQ ID NO:9.The bead is connected 5′ to 3′ to the oligonucleotide which encodes the anchor primer sequence, the bar code (N20) and an oligo dT primer.", "Example 5 Introduction of One Unique Bar-Coded Bead Per Cell FIG.", "4 demonstrates introduction of beads carrying unique bar-coded oligonucleotides into individual cells.", "Here, beads post-emulsion PCR are sequenced for one base of their bar-code to show that each beads have a unique bar-code and demonstrate clonality.", "Each nucleotide is queried by a different fluorophores as describe previously (Porreca et al.", "(2006) Curr.", "Protoc.", "Mol.", "Biol.", "Chapter 7:Unit 78).", "Cy 5 shows presence of an adenine nucleotide at position one of the bar-code.", "Cy3 the shows presence of a thymine nucleotide at position one of the bar-code Texas Red (Txred) shows the presence of a cytosine nucleotide at position one of the bar-code.", "Fluorescein isothiocyanate (FITC) shows the presence of a guanine at position one of the bar-code.", "The image overlay of all four fluorophores for a single position on the bar-codes is shown and demonstrates clonality.", "Clonality refers to each single bead harboring one unique bar-code, which has been successfully amplified onto the bead.", "If the beads had contained multiple bar-codes; that is, had been non-clonal (for example, having multiple bar-code templates loaded on the bead by accident), the overlay would have demonstrated more than one fluorophore color per bead when querying a single position on the bar-code during sequencing.", "Complete sequencing of the bar-code, which allows correlation to the cell, is by multiple successive round of sequencing for each nucleotide position.", "White light microscopy analysis of the beads and emulsion reaction shows that the starting template and the bead in emulsion were correctly diluted to achieve a maximum of one bead or less per emulsion and one template or less per bead.", "Example 6 Introduction of Unique Bar-Coded Oligonucleotides on a Grid Support Multiple copies of the same unique bar-code for single cell analysis were made by rolling circle amplification (RCA) product (Rolony) from a circularized starting bar-code unique oligonucleotide (FIG.", "5).", "See U.S.", "Published Application No.", "20090018024.The uniquely bar-coded Rolony is cleaved into targeting bar-coded oligonucleotides when incubated in presence of a complementary restriction compatible DNA fragment and restriction enzyme.", "Cleavage may also be performed for example, in liposomes or inside emulsions.", "Liposomes containing bar-coded oligonucleotides were then fused to cells, allowing the annealing primer to anneal to the target nucleic acid of interest in each cell, as described in the bead-based approach.", "FIG.", "5 shows the query of the Rolony (similar to the query of the bar-coded beads, but ordered on a grid) to demonstrate efficiency at generating uniquely bar-coded clonal Rolony.", "FIG.", "5 demonstrates the rolony are clonally amplified, because for each query of a single position only one fluorophore overlays for that position.", "Subsequent sequencing of the other nucleotide positions can be performed to identify the complete bar-codes (used to correlated to the single originating cell) and to identify the captured transcripts." ] ]
Patent_15874137
[ [ "TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS", "The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases." ], [ "1-67.", "(canceled) 68.A method of inhibiting JAK1 activity in a patient, comprising administering to said patient a compound, which is ((2R,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile, or a pharmaceutically acceptable salt thereof.", "69.The method of claim 68, wherein the compound is ((2R,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile monohydrate.", "70.A method of treating a disease in a patient, comprising administering to said patient a compound, which is ((2R,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile, or a pharmaceutically acceptable salt thereof, wherein said disease is selected from allograft rejection, graft versus host disease, multiple sclerosis, rheumatoid arthritis, type I diabetes, lupus, Crohn's disease, myasthenia gravis, ulcerative colitis, psoriasis, contact dermatitis, prostate cancer, renal cancer, pancreatic cancer, breast cancer, lung cancer, Castleman's disease, lymphoma, leukemia, multiple myeloma, polycythemia vera (PV), essential thrombocythemia (ET), myelofibrosis (MF), chronic myelogenous leukemia (CML), chronic myelomonocytic leukemia (CMML), hypereosinophilic syndrome (HES), systemic mast cell disease (SMCD), myelodysplasic syndrome, bone resorption, osteoporosis, pemphigus vulgaris, asthma, scleroderma, ankylosing spondylitis, acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), cutaneous T-cell lymphoma (CTCL), mycosis, fungoides, colon cancer, colorectal cancer, acneiform rash, and cachexia.", "71.The method of claim 70, wherein the compound is ((2R,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile monohydrate.", "73.The method of claim 70, wherein the disease is allograft rejection.", "74.The method of claim 70, wherein the disease is graft versus host disease.", "75.The method of claim 70, wherein the disease is multiple sclerosis.", "76.The method of claim 70, wherein the disease is rheumatoid arthritis.", "77.The method of claim 70, wherein the disease is type I diabetes.", "78.The method of claim 70, wherein the disease is lupus.", "79.The method of claim 78, wherein the lupus is systemic lupus erythematosus.", "80.The method of claim 70, wherein the disease is Crohn's disease.", "81.The method of claim 70, wherein the disease is ulcerative colitis.", "82.The method of claim 70, wherein the disease is myasthenia gravis.", "83.The method of claim 70, wherein the disease is psoriasis.", "84.The method of claim 70, wherein the disease is contact dermatitis.", "85.The method of claim 70, wherein the disease is selected from prostate cancer, renal cancer, pancreatic cancer, breast cancer, lung cancer, Castleman's disease, lymphoma, leukemia, and multiple myeloma.", "86.The method of claim 70, wherein said disease is myelofibrosis.", "87.The method of claim 86, wherein said myelofibrosis is selected from primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (Post-PV MF), and post-essential thrombocythemia myelofibrosis (Post-ET MF).", "88.The method of claim 70, wherein the disease is polycythemia vera (PV).", "89.The method of claim 70, wherein the disease is essential thrombocythemia (ET).", "90.The method of claim 70, wherein the disease is selected from chronic myelogenous leukemia (CML), chronic myelomonocytic leukemia (CMML), hypereosinophilic syndrome (HES), and systemic mast cell disease (SMCD).", "91.The method of claim 70, wherein the disease is myelodysplasic syndrome.", "92.The method of claim 70, wherein the disease is bone resorption or osteoporosis.", "93.The method of claim 70, wherein the disease is pemphigus vulgaris.", "94.The method of claim 70, wherein the disease is asthma.", "95.The method of claim 70, wherein the disease is scleroderma.", "96.The method of claim 70, wherein the disease is ankylosing spondylitis.", "97.The method of claim 70, wherein the disease is acute lymphoblastic leukemia (ALL).", "98.The method of claim 70, wherein the disease is acute myelogenous leukemia (AML).", "99.The method of claim 70, wherein the disease is cutaneous T-cell lymphoma (CTCL).", "100.The method of claim 70, wherein the disease is mycosis fungoides.", "101.The method of claim 70, wherein the disease is colon cancer or colorectal cancer.", "102.The method of claim 70, wherein the disease is acneiform rash.", "103.The method of claim 70, wherein the disease is cachexia." ], [ "<SOH> BACKGROUND <EOH>Protein kinases (PKs) regulate diverse biological processes including cell growth, survival, differentiation, organ formation, morphogenesis, neovascularization, tissue repair, and regeneration, among others.", "Protein kinases also play specialized roles in a host of human diseases including cancer.", "Cytokines, low-molecular weight polypeptides or glycoproteins, regulate many pathways involved in the host inflammatory response to sepsis.", "Cytokines influence cell differentiation, proliferation and activation, and can modulate both pro-inflammatory and anti-inflammatory responses to allow the host to react appropriately to pathogens.", "Signaling of a wide range of cytokines involves the Janus kinase family (JAKs) of protein tyrosine kinases and Signal Transducers and Activators of Transcription (STATs).", "There are four known mammalian JAKs: JAK1 (Janus kinase-1), JAK2, JAK3 (also known as Janus kinase, leukocyte; JAKL; and L-JAK), and TYK2 (protein-tyrosine kinase 2).", "Cytokine-stimulated immune and inflammatory responses contribute to pathogenesis of diseases: pathologies such as severe combined immunodeficiency (SCID) arise from suppression of the immune system, while a hyperactive or inappropriate immune/inflammatory response contributes to the pathology of autoimmune diseases (e.g., asthma, systemic lupus erythematosus, thyroiditis, myocarditis), and illnesses such as scleroderma and osteoarthritis (Ortmann, R. A., T. Cheng, et al.", "(2000) Arthritis Res 2(1): 16-32).", "Deficiencies in expression of JAKs are associated with many disease states.", "For example, Jak1−/− mice are runted at birth, fail to nurse, and die perinatally (Rodig, S. J., M. A. Meraz, et al.", "(1998) Cell 93(3): 373-83).", "Jak2−/− mouse embryos are anemic and die around day 12.5 postcoitum due to the absence of definitive erythropoiesis.", "The JAK/STAT pathway, and in particular all four JAKs, are believed to play a role in the pathogenesis of asthmatic response, chronic obstructive pulmonary disease, bronchitis, and other related inflammatory diseases of the lower respiratory tract.", "Multiple cytokines that signal through JAKs have been linked to inflammatory diseases/conditions of the upper respiratory tract, such as those affecting the nose and sinuses (e.g., rhinitis and sinusitis) whether classically allergic reactions or not.", "The JAK/STAT pathway has also been implicated in inflammatory diseases/conditions of the eye and chronic allergic responses.", "Activation of JAK/STAT in cancers may occur by cytokine stimulation (e.g.", "IL-6 or GM-CSF) or by a reduction in the endogenous suppressors of JAK signaling such as SOCS (suppressor or cytokine signaling) or PIAS (protein inhibitor of activated STAT) (Boudny, V., and Kovarik, J., Neoplasm.", "49:349-355, 2002).", "Activation of STAT signaling, as well as other pathways downstream of JAKs (e.g., Akt), has been correlated with poor prognosis in many cancer types (Bowman, T., et al.", "Oncogene 19:2474-2488, 2000).", "Elevated levels of circulating cytokines that signal through JAK/STAT play a causal role in cachexia and/or chronic fatigue.", "As such, JAK inhibition may be beneficial to cancer patients for reasons that extend beyond potential anti-tumor activity.", "JAK2 tyrosine kinase can be beneficial for patients with myeloproliferative disorders, e.g., polycythemia vera (PV), essential thrombocythemia (ET), myeloid metaplasia with myelofibrosis (MMM) (Levin, et al., Cancer Cell , vol.", "7, 2005: 387-397).", "Inhibition of the JAK2V617F kinase decreases proliferation of hematopoietic cells, suggesting JAK2 as a potential target for pharmacologic inhibition in patients with PV, ET, and MMM.", "Inhibition of the JAKs may benefit patients suffering from skin immune disorders such as psoriasis, and skin sensitization.", "The maintenance of psoriasis is believed to depend on a number of inflammatory cytokines in addition to various chemokines and growth factors (JCI, 113:1664-1675), many of which signal through JAKs ( Adv Pharmacol.", "2000; 47:113-74).", "Thus, new or improved agents which inhibit kinases such as JAKs are continually needed for developing new and more effective pharmaceuticals that are aimed at augmentation or suppression of the immune and inflammatory pathways (such as immunosuppressive agents for organ transplants), as well as agents for the prevention and treatment of autoimmune diseases, diseases involving a hyperactive inflammatory response (e.g., eczema), allergies, cancer (e.g., prostate, leukemia, multiple myeloma), and some immune reactions (e.g., skin rash or contact dermatitis or diarrhea) caused by other therapeutics.", "The compounds of the invention, as well as its compositions and methods described herein are directed toward these needs and other ends." ], [ "<SOH> SUMMARY <EOH>The present invention provides, inter alia, compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Y, X 1 , X 2 , X 3 , X 4 , X 5 , R 5 , and are defined infra.", "The present invention further provides compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.", "The present invention further provides methods of modulating an activity of JAK1 comprising contacting JAK1 with a compound of Formula I, or a pharmaceutically acceptable salt thereof.", "The present invention further provides methods of treating a disease or a disorder associated with abnormal kinase expression or activity in a patient by administering to a patient a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof.", "The present invention further provides methods of treating an autoimmune disease, a cancer, a myeloproliferative disorder, an inflammatory disease, a bone resorption disease, or organ transplant rejection in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof.", "The present invention also provides compounds of Formula I, or pharmaceutically acceptable salts thereof, as described herein for use in treatment of autoimmune diseases, cancer, myeloproliferative disorders, inflammatory diseases, a bone resorption disease, or organ transplant rejection.", "The present invention further provides compounds of Formula I as described herein, or pharmaceutically acceptable salts thereof, for use in modulating JAK1.The present invention also provides uses of compounds of Formula I as described herein, or pharmaceutically acceptable salts thereof, for the preparation of medicaments for use in methods of modulating JAK1.detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "This application is a continuation of U.S. Ser.", "No.", "14/873,078, filed Oct. 1, 2015, which is a continuation of U.S. Ser.", "No.", "14/068,796, filed Oct. 31, 2013, which claims the benefit of priority of U.S.", "Provisional Application No.", "61/721,308, filed Nov. 1, 2012, and U.S.", "Provisional Application No.", "61/783,850, filed Mar.", "14, 2013, each of which is incorporated herein by reference in its entirety.", "TECHNICAL FIELD The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.", "BACKGROUND Protein kinases (PKs) regulate diverse biological processes including cell growth, survival, differentiation, organ formation, morphogenesis, neovascularization, tissue repair, and regeneration, among others.", "Protein kinases also play specialized roles in a host of human diseases including cancer.", "Cytokines, low-molecular weight polypeptides or glycoproteins, regulate many pathways involved in the host inflammatory response to sepsis.", "Cytokines influence cell differentiation, proliferation and activation, and can modulate both pro-inflammatory and anti-inflammatory responses to allow the host to react appropriately to pathogens.", "Signaling of a wide range of cytokines involves the Janus kinase family (JAKs) of protein tyrosine kinases and Signal Transducers and Activators of Transcription (STATs).", "There are four known mammalian JAKs: JAK1 (Janus kinase-1), JAK2, JAK3 (also known as Janus kinase, leukocyte; JAKL; and L-JAK), and TYK2 (protein-tyrosine kinase 2).", "Cytokine-stimulated immune and inflammatory responses contribute to pathogenesis of diseases: pathologies such as severe combined immunodeficiency (SCID) arise from suppression of the immune system, while a hyperactive or inappropriate immune/inflammatory response contributes to the pathology of autoimmune diseases (e.g., asthma, systemic lupus erythematosus, thyroiditis, myocarditis), and illnesses such as scleroderma and osteoarthritis (Ortmann, R. A., T. Cheng, et al.", "(2000) Arthritis Res 2(1): 16-32).", "Deficiencies in expression of JAKs are associated with many disease states.", "For example, Jak1−/− mice are runted at birth, fail to nurse, and die perinatally (Rodig, S. J., M. A. Meraz, et al.", "(1998) Cell 93(3): 373-83).", "Jak2−/− mouse embryos are anemic and die around day 12.5 postcoitum due to the absence of definitive erythropoiesis.", "The JAK/STAT pathway, and in particular all four JAKs, are believed to play a role in the pathogenesis of asthmatic response, chronic obstructive pulmonary disease, bronchitis, and other related inflammatory diseases of the lower respiratory tract.", "Multiple cytokines that signal through JAKs have been linked to inflammatory diseases/conditions of the upper respiratory tract, such as those affecting the nose and sinuses (e.g., rhinitis and sinusitis) whether classically allergic reactions or not.", "The JAK/STAT pathway has also been implicated in inflammatory diseases/conditions of the eye and chronic allergic responses.", "Activation of JAK/STAT in cancers may occur by cytokine stimulation (e.g.", "IL-6 or GM-CSF) or by a reduction in the endogenous suppressors of JAK signaling such as SOCS (suppressor or cytokine signaling) or PIAS (protein inhibitor of activated STAT) (Boudny, V., and Kovarik, J., Neoplasm.", "49:349-355, 2002).", "Activation of STAT signaling, as well as other pathways downstream of JAKs (e.g., Akt), has been correlated with poor prognosis in many cancer types (Bowman, T., et al.", "Oncogene 19:2474-2488, 2000).", "Elevated levels of circulating cytokines that signal through JAK/STAT play a causal role in cachexia and/or chronic fatigue.", "As such, JAK inhibition may be beneficial to cancer patients for reasons that extend beyond potential anti-tumor activity.", "JAK2 tyrosine kinase can be beneficial for patients with myeloproliferative disorders, e.g., polycythemia vera (PV), essential thrombocythemia (ET), myeloid metaplasia with myelofibrosis (MMM) (Levin, et al., Cancer Cell, vol.", "7, 2005: 387-397).", "Inhibition of the JAK2V617F kinase decreases proliferation of hematopoietic cells, suggesting JAK2 as a potential target for pharmacologic inhibition in patients with PV, ET, and MMM.", "Inhibition of the JAKs may benefit patients suffering from skin immune disorders such as psoriasis, and skin sensitization.", "The maintenance of psoriasis is believed to depend on a number of inflammatory cytokines in addition to various chemokines and growth factors (JCI, 113:1664-1675), many of which signal through JAKs (Adv Pharmacol.", "2000; 47:113-74).", "Thus, new or improved agents which inhibit kinases such as JAKs are continually needed for developing new and more effective pharmaceuticals that are aimed at augmentation or suppression of the immune and inflammatory pathways (such as immunosuppressive agents for organ transplants), as well as agents for the prevention and treatment of autoimmune diseases, diseases involving a hyperactive inflammatory response (e.g., eczema), allergies, cancer (e.g., prostate, leukemia, multiple myeloma), and some immune reactions (e.g., skin rash or contact dermatitis or diarrhea) caused by other therapeutics.", "The compounds of the invention, as well as its compositions and methods described herein are directed toward these needs and other ends.", "SUMMARY The present invention provides, inter alia, compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Y, X1, X2, X3, X4, X5, R5, and are defined infra.", "The present invention further provides compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.", "The present invention further provides methods of modulating an activity of JAK1 comprising contacting JAK1 with a compound of Formula I, or a pharmaceutically acceptable salt thereof.", "The present invention further provides methods of treating a disease or a disorder associated with abnormal kinase expression or activity in a patient by administering to a patient a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof.", "The present invention further provides methods of treating an autoimmune disease, a cancer, a myeloproliferative disorder, an inflammatory disease, a bone resorption disease, or organ transplant rejection in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof.", "The present invention also provides compounds of Formula I, or pharmaceutically acceptable salts thereof, as described herein for use in treatment of autoimmune diseases, cancer, myeloproliferative disorders, inflammatory diseases, a bone resorption disease, or organ transplant rejection.", "The present invention further provides compounds of Formula I as described herein, or pharmaceutically acceptable salts thereof, for use in modulating JAK1.The present invention also provides uses of compounds of Formula I as described herein, or pharmaceutically acceptable salts thereof, for the preparation of medicaments for use in methods of modulating JAK1.DETAILED DESCRIPTION The present invention provides, inter alia, a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: the ring system is aromatic; each is independently selected from a single bond and a double bond; Y is N or CR4; X1 is selected from CR1, CR1R1a, C(═O), N, NR1, O, and S; X2 is selected from CR2, C(═O), N, NR2, and C(═NR2a); X3 is selected from CR3 and NR3; X4 is selected from C and N; and X5 is C; or X4 is C; and X5 is selected from C and N; provided that: (i) the selections for each of X1, X2, X3, X4, X5 and maintain proper valency; (ii) when X1 is O or S, then X2 is not NR2 and X2X3 is not —C(═O)—CR3—; (iii) when X1 is NR1, then X2X3 is not —NR2—NR3—; (iv) when X4 is N, then X1X2X3 is not ═N—NR2—NR3—; and (v) when X5 is N, then X1X2 is not —NR1—NR2— and X1X2X3 is not —CR1R1a—NR2—CR3═; R1 is selected from H, halo, CN, NH2, C1-3 alkyl, C1-3 alkoxy, and C1-3 haloalkyl; R1a is selected from H, halo, CN, NH2, C1-3 alkyl, and C1-3 haloalkyl; R2a is selected from CN, OH, OCH3, and NO2; R2 is selected from H, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkyl-S—, CN, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, C(═NRe)Rb, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, and C1-6 alkyl-S— are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy2, halo, CN, NO2, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; alternatively, R2 is selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, R21, Cy2, CN, NO2, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; provided that when X1X2X3 is —N═CR2—NR3—, X4 is C, and X5 is C; and Cy4 is unsubstituted or substituted 3-10 membered saturated heterocycloalkylene having one or more nitrogen atoms or Cy4A is unsubstituted or substituted 3-10 membered saturated heterocycloalkylene having one or more nitrogen atoms, then R2 is selected from H, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkyl-S—, CN, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, C(═NRe)Rb, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, and C1-6 alkyl-S— are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy2, halo, CN, NO2, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; each R21 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy2, halo, CN, NO2, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; alternatively, when two R21 groups are attached to the same carbon atom, the two R21 groups, along with the carbon atom to which they are attached, form a 3-7 membered cycloalkyl ring or a 3-7 membered heterocycloalkyl ring, wherein 1 or 2 ring members of said heterocycloalkyl ring are independently selected from N, O and S; and wherein said cycloalkyl ring and heterocycloalkyl ring are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, OH, CN, C1-3 alkyl, C1-3 alkoxy, and C1-3 haloalkyl; each Cy2 is independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, R22, CN, NO2, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; each Ra, Rc, and Rd are independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa1, SRa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1C(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1; each Rb is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa1, SRa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1C(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1; each Re is independently selected from H, CN, OH, C1-4 alkyl, C1-4 alkoxy, NO2, C(O)(C1-4 alkyl), and S(═O)2(C1-4 alkyl); each R22 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy3, halo, CN, NO2, ORa1, SRa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1C(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1; each Ra1, Rc1, and Rd1 are independently selected from H, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, and C1-3 haloalkyl; each Rb1 is independently selected from C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, and C1-3 haloalkyl; each Re1 is independently selected from H, CN, OH, C1-4 alkyl, and C1-4 alkoxy; each Cy3 is independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halo, CN, NO2, ORa1, SRa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1C(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1; R3 is selected from Cy4, -Cy4A-Cy5, -Cy4A-Y1-Cy5, -Cy4A-Y-Cy5SA-Cy6, -Cy4A-Cy5A-Y2-Cy6, -Cy4A-Y1-Cy5A-Y2-Cy6, or -Cy4A-Y3-Cy6; Cy4 is selected from C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups; Cy4A is selected from C6-10 arylene, C3-10 cycloalkylene, 5-10 membered heteroarylene, and 3-10 membered heterocycloalkylene, wherein said C6-10 arylene, C3-10 cycloalkylene, 5-10 membered heteroarylene, and 3-10 membered heterocycloalkylene are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups; Y1 is Y11, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C1-6 alkylene-Y11, C2-6 alkenylene-Y11, C2-6 alkynylene-Y11, Y11—C1-6 alkylene, Y11—C2-6 alkenylene, or Y11—C2-6 alkynylene, wherein said alkylene, alkenylene and alkynylene groups are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy; Cy5 and Cy6 are each independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R32 groups; Cy5A is selected from C6-10 arylene, C3-10 cycloalkylene, 5-10 membered heteroarylene, and 3-10 membered heterocycloalkylene, wherein said C6-10 arylene, C3-10 cycloalkylene, 5-10 membered heteroarylene, and 3-10 membered heterocycloalkylene are each optionally substituted with 1, 2, 3, or 4 independently selected R32 groups; Y2 is Y21, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C1-6 alkylene-Y21, C2-6 alkenylene-Y21, C2-6 alkynylene-Y21, Y21—C1-6 alkylene, Y21—C2-6 alkenylene, or Y21—C2-6 alkynylene, wherein said alkylene, alkenylene and alkynylene groups are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy; Y3 is C1-6 alkylene-Y31—C1-6 alkylene, C1-6 alkylene-Y31—C1-6 alkylene-Y31, or Y31—C1-6 alkylene-Y31—C1-6 alkylene, wherein said alkylene groups are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy; each Cy7 is independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 independently selected R33 groups; Y11, Y21, and Y31 are each independently selected from O, S, C(═O), C(═O)NRf, C(═O)O, OC(═O), OC(═O)NRf, NRf, NRfC(═O), NRfC(═O)O, NRfC(═O)NRf, NRfS(═O), NRfS(═O)2, NRfS(═O)2NRf, S(═O), S(═O)NRf, S(═O)2, and S(═O)2NRf; each R31 is independently selected from Cy7, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halo, CN, NO2, ORa2, SRa2, C(═O)Rb2, C(═O)NRc2Rd2, C(═O)ORa2, OC(═O)Rb2, OC(═O)NRc2Rd2, C(═NRe2)NRc2Rd2, NRc2C(═NRe2)NRc2Rd2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)Rb2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)Rb2, S(═O)NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, NO2, ORa2, SRa2, C(═O)Rb2, C(═O)NRc2Rd2, C(═O)OR2, OC(═O)Rb2, OC(═O)NRc2Rd2, C(═NRe2)NRc2Rd2, NRc2C(═NRe2)NRc2Rd2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)Rb2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)Rb2, S(═O)NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each R32 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halo, CN, NO2, ORa2, SRa2, C(═O)Rb2, C(═O)NRc2Rd2, C(═O)OR2, OC(═O)Rb2, OC(═O)NRc2Rd2, C(═NRe2)NRc2Rd2, NRc2C(═NRe2)NRc2Rd2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)Rb2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)Rb2, S(═O)NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, NO2, ORa2, SRa2, C(═O)Rb2, C(═O)NRc2Rd2, C(═O)ORa2, OC(═O)Rb2, OC(═O)NRc2Rd2, C(═NRe2)NRc2Rd2, NRc2C(═NRe2)NRc2Rd2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)Rb2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)Rb2, S(═O)NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each R33 is independently selected from halo, OH, NO2, CN, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, C1-3 alkoxy-C1-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, di(C1-3 alkyl)amino, thio, C1-3 alkylthio, C1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di(C1-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkylsulfonylamino, aminosulfonyl, C1-3 alkylaminosulfonyl, di(C1-3 alkyl)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(C1-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino, and di(C1-3 alkyl)aminocarbonylamino; alternatively, when two R33 groups are attached to the same carbon atom, the two R33 groups, along with the carbon atom to which they are attached, form a 3-7 membered cycloalkyl ring or a 3-7 membered heterocycloalkyl ring, wherein 1 or 2 ring members of said heterocycloalkyl ring are independently selected from N, O and S; and wherein said cycloalkyl ring and heterocycloalkyl ring are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, OH, CN, C1-3 alkyl, C1-3 alkoxy, and C1-3 haloalkyl; each Ra2, Rc2, and Rd2 are independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from R33; each Rb2 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from R33; each Re2 is independently selected from H, CN, OH, C1-4 alkyl, and C1-4 alkoxy; each Rf is independently selected from H and C1-3 alkyl; R4 is selected from H, halo, CN, NH2, C1-3 alkyl, and C1-3 haloalkyl; and R5 is selected from H, halo, cyano, hydroxy, amino, (C1-4 alkyl)amino, di(C1-4 alkyl)amino, C1-4 alkyl, C1-4 haloalkyl, and C1-4 alkoxy.", "In some embodiments: the ring system is aromatic; each independently selected from a single bond and a double bond; Y is N or CR4; X1 is selected from CR1, CR1R1a, C(═O), N, NR1, O, and S; X2 is selected from CR2, C(═O), N, NR2, and C(═NR2a); X3 is selected from CR3 and NR3; X4 is selected from C and N; and X5 is C; or X4 is C; and X5 is selected from C and N; provided that: (i) the selections for each of X1, X2, X3, X4, X5 and maintain proper valency; (ii) when X1 is O or S, then X2 is not NR2 and X2X3 is not —C(═O)—CR3—; (iii) when X1 is NR1, then X2X3 is not —NR2—NR3—; (iv) when X4 is N, then X1X2X3 is not ═N—NR2—NR3—; and (v) when X5 is N, then X1X2 is not —NR1—NR2— and X1X3 is not —CR1R1a—NR2—CR3═; R1 is selected from H, halo, CN, NH2, C1-3 alkyl, C1-3 alkoxy, and C1-3 haloalkyl; R1a is selected from H, halo, CN, NH2, C1-3 alkyl, and C1-3 haloalkyl; R2a is selected from CN, OH, OCH3, and NO2; R2 is selected from H, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkyl-S—, CN, OC(═O)Rb, OC(═O)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, C(═NRe)Rb, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, and C1-6 alkyl-S— are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy2, halo, CN, NO2, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; alternatively, R2 is selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, R21, Cy2, CN, NO2, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; each R21 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy2, halo, CN, NO2, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; alternatively, when two R21 groups are attached to the same carbon atom, the two R21 groups, along with the carbon atom to which they are attached, form a 3-7 membered cycloalkyl ring or a 3-7 membered heterocycloalkyl ring, wherein 1 or 2 ring members of said heterocycloalkyl ring are independently selected from N, O and S; and wherein said cycloalkyl ring and heterocycloalkyl ring are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, OH, CN, C1-3 alkyl, C1-3 alkoxy, and C1-3 haloalkyl; each Cy2 is independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, R22, CN, NO2, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; each Ra, Rc, and Rd are independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa1, SRa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1C(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1; each Rb is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa1, SRa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1C(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1; each Re is independently selected from H, CN, OH, C1-4 alkyl, C1-4 alkoxy, NO2, C(O)(C1-4 alkyl), and S(═O)2(C1-4 alkyl); each R22 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy3, halo, CN, NO2, ORa1, SRa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1CC(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1; each Ra1, Rc1, and Rd1 are independently selected from H, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, and C1-3 haloalky; each Rb1 is independently selected from C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, and C1-3 haloalkyl; each Re1 is independently selected from H, CN, OH, C1-4 alkyl, and C1-4 alkoxy; each Cy3 is independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halo, CN, NO2, ORa1, SRa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1C(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1; R3 is Cy4, -Cy4A-Cy5, -Cy4A-Y1-Cy5, -Cy4A-Y1-Cy5A-Cy6, -Cy4A-Cy5A-Y2-Cy6, -Cy4A-Y1-Cy5A-Y2-Cy6, or -Cy4A-Y3-Cy6; Cy4 is selected from C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, wherein said 3-10 membered heterocycloalkyl is not a saturated heterocycloalkyl group having one or more nitrogen ring members; Cy4A is selected from C6-10 arylene, C3-10 cycloalkylene, 5-10 membered heteroarylene, and 3-10 membered heterocycloalkylene, wherein said C6-10 arylene, C3-10 cycloalkylene, 5-10 membered heteroarylene, and 3-10 membered heterocycloalkylene are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, wherein said 3-10 membered heterocycloalkylene is not a saturated heterocycloalkylene group having one or more nitrogen ring members; Y1 is Y11, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C1-6 alkylene-Y11, C2-6 alkenylene-Y11, C2-6 alkynylene-Y11, Y11—C1-6 alkylene, Y11—C2-6 alkenylene, or Y11—C2-6 alkynylene, wherein said alkylene, alkenylene and alkynylene groups are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy; Cy5 and Cy6 are each independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R32 groups; Cy5A is selected from C6-10 arylene, C3-10 cycloalkylene, 5-10 membered heteroarylene, and 3-10 membered heterocycloalkylene, wherein said C6-10 arylene, C3-10 cycloalkylene, 5-10 membered heteroarylene, and 3-10 membered heterocycloalkylene are each optionally substituted with 1, 2, 3, or 4 independently selected R32 groups; Y2 is Y21, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C1-6 alkylene-Y21, C2-6 alkenylene-Y21, C2-6 alkynylene-Y21, Y21—C1-6 alkylene, Y21—C2-6 alkenylene, or Y21—C2-6 alkynylene, wherein said alkylene, alkenylene and alkynylene groups are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy; Y3 is C1-6 alkylene-Y31—C1-6 alkylene, C1-6 alkylene-Y31—C1-6 alkylene-Y31, or Y31—C1-6 alkylene-Y31—C1-6 alkylene, wherein said alkylene groups are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy; each Cy7 is independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, 4, or 5 independently selected R33 groups; Y11, Y21, and Y31 are each independently selected from O, S, C(═O), C(═O)NRf, C(═O)O, OC(═O), OC(═O)NRf, NRf, NRfC(═O), NRfC(═O)O, NRfC(═O)NRf, NRfS(═O), NRfS(═O)2, NRfS(═O)2NRf, S(═O), S(═O)NRf, S(═O)2, and S(═O)2NRf; each R31 is independently selected from Cy7, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halo, CN, NO2, ORa2, SRa2, C(═O)Rb2, C(═O)NRc2Rd2, C(═O)ORa2, OC(═O)Rb2, OC(═O)NRc2Rd2, C(═NRe2)NRc2Rd2, NRc2C(═NRe2)NRc2Rd2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)Rb2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)Rb2, S(═O)NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, NO2, ORa2, SRa2, C(═O)Rb2, C(═O)NRc2Rd2, C(═O)ORa2, OC(═O)Rb2, OC(═O)NRc2Rd2, C(═NRe2)NRc2Rd2, NRc2C(═NRe2)NRc2Rd2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)Rb2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)Rb2, S(═O)NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each R32 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halo, CN, NO2, ORa2, SRa2, C(═O)Rb2, C(═O)NRc2Rd2, C(═O)ORa2, OC(═O)Rb2, OC(═O)NRc2Rd2, C(═NRe2)NRc2Rd2, NRc2C(═NRe2)NRc2Rd2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)Rb2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)Rb2, S(═O)NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, NO2, ORa2, SRa2, C(═O)Rb2, C(═O)NRc2Rd2, C(═O)ORa2, OC(═O)Rb2, OC(═O)NRc2Rd2, C(═NRe2)NRc2Rd2, NRc2C(═NRe2)NRc2Rd2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORz2, NRc2C(═O)NRc2Rd2, NRc2S(═O)Rb2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)Rb2, S(═O)NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each R33 is independently selected from halo, OH, NO2, CN, C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, C1-3 alkoxy-C1-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, di(C1-3 alkyl)amino, thio, C1-3 alkylthio, C1-3 alkylsulfinyl, C1-3 alkylsulfonyl, carbamyl, C1-3 alkylcarbamyl, di(C1-3 alkyl)carbamyl, carboxy, C1-3 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-3 alkylcarbonyloxy, C1-3 alkylcarbonylamino, C1-3 alkylsulfonylamino, aminosulfonyl, C1-3 alkylaminosulfonyl, di(C1-3 alkyl)aminosulfonyl, aminosulfonylamino, C1-3 alkylaminosulfonylamino, di(C1-3 alkyl)aminosulfonylamino, aminocarbonylamino, C1-3 alkylaminocarbonylamino, and di(C1-3 alkyl)aminocarbonylamino; alternatively, when two R33 groups are attached to the same carbon atom, the two R33 groups, along with the carbon atom to which they are attached, form a 3-7 membered cycloalkyl ring or a 3-7 membered heterocycloalkyl ring, wherein 1 or 2 ring members of said heterocycloalkyl ring are independently selected from N, O and S; and wherein said cycloalkyl ring and heterocycloalkyl ring are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, OH, CN, C1-3 alkyl, C1-3 alkoxy, and C1-3 haloalkyl; each Ra2, Rc2, and Rd2 are independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from R33; each Rb2 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from R33; each Re2 is independently selected from H, CN, OH, C1-4 alkyl, and C1-4 alkoxy; each Rf is independently selected from H and C1-3 alkyl; R4 is selected from H, halo, CN, NH2, C1-3 alkyl, and C1-3 haloalkyl; and R5 is selected from H, halo, cyano, hydroxy, amino, (C1-4 alkyl)amino, di(C1-4 alkyl)amino, C1-4 alkyl, C1-4 haloalkyl, and C1-4 alkoxy.", "In some embodiments: R2 is H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkyl-S—, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)2Rb, and S(═O)2NRcRd; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C1-6 alkoxy, and C1-6 alkyl-S— are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; Ra, Rc, and Rd are independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1C(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1; and each Rb is independently selected from C1-6 alkyl and C1-6 haloalkyl, wherein said C1-6 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from halo, C1-6 alkyl, CN, ORa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1C(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1.In some embodiments: R2 is C1-6 alkyl, which is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; Ra, Rc, and Rd are independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1C(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1.each Rb is independently selected from C1-6 alkyl and C1-6 haloalkyl, wherein said C1-6 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from halo, C1-6 alkyl, CN, ORa1, C(═O)Rb1, C(═O)NRc1Rd1, C(═O)ORa1, OC(═O)Rb1, OC(═O)NRc1Rd1, C(═NRe1)NRc1Rd1, NRc1C(═NRe1)NRc1Rd1, NRc1Rd1, NRc1C(═O)Rb1, NRc1C(═O)ORa1, NRc1C(═O)NRc1Rd1, NRc1S(═O)Rb1, NRc1S(═O)2Rb1, NRc1S(═O)2NRc1Rd1, S(═O)Rb1, S(═O)NRc1Rd1, S(═O)2Rb1, and S(═O)2NRc1Rd1.In some embodiments, R2 is C1-6 alkyl, C1-6 alkoxy, and C1-6 alkyl-S—, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, C1-6 alkoxy, S(C1-6 alkyl), C(═O)(C1-6 alkyl), C(═O)NH2, C(═O)NH(C1-6 alkyl), C(═O)N(C1-6 alkyl)2, C(═O)O(C1-6 alkyl), OC(═O)(C1-6 alkyl), OC(═O)NH2, OC(═O)NH(C1-6 alkyl), OC(═O)N(C1-6 alkyl)2, C(═NH)NH2, C(═NH)NH(C1-6 alkyl), C(═NH)N(C1-6 alkyl)2, NHC(═NH)NH2, NHC(═NH)NH(C1-6 alkyl), NHC(═NH)N(C1-6 alkyl)2, NH2, NH(C1-6 alkyl), N(C1-6 alkyl)2, NHC(═O)(C1-6 alkyl), N(C1-6 alkyl)C(═O) (C1-6 alkyl), NHC(═O)(C1-6 alkyl), NHC(═O)O(C1-6 alkyl), N(C1-6 alkyl)C(═O)O(C1-6 alkyl), NHC(═O)NH2, NHC(═O)NH(C1-6 alkyl), NHC(═O)N(C1-6 alkyl)2, NHS(═O)(C1-6 alkyl), N(C1-6 alkyl)S(═O)(C1-6 alkyl), NHS(═O)2(C1-6 alkyl), N(C1-6 alkyl)S(═O)2(C1-6 alkyl), NHS(═O)2NH2, NHS(═O)2NH(C1-6 alkyl), NHS(═O)2N(C1-6 alkyl)2, S(═O)(C1-6 alkyl), S(═O)NH2, S(═O)NH(C1-6 alkyl), S(═O)N(C1-6 alkyl)2, S(═O)2(C1-6 alkyl), S(═O)2NH2, S(═O)2NH(C1-6 alkyl), and S(═O)2N(C1-6 alkyl)2.In some embodiments, R2 is C1-6 alkyl, which is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, C1-6 alkoxy, S(C1-6 alkyl), C(═O)(C1-6 alkyl), C(═O)NH2, C(═O)NH(C1-6 alkyl), C(═O)N(C1-6 alkyl)2, C(═O)O(C1-6 alkyl), OC(═O)(C1-6 alkyl), OC(═O)NH2, OC(═O)NH(C1-6 alkyl), OC(═O)N(C1-6 alkyl)2, C(═NH)NH2, C(═NH)NH(C1-6 alkyl), C(═NH)N(C1-6 alkyl)2, NHC(═NH)NH2, NHC(═NH)NH(C1-6 alkyl), NHC(═NH)N(C1-6 alkyl)2, NH2, NH(C1-6 alkyl), N(C1-6 alkyl)2, NHC(═O)(C1-6 alkyl), N(C1-6 alkyl)C(═O) (C1-6 alkyl), NHC(═O)(C1-6 alkyl), NHC(═O)O(C1-6 alkyl), N(C1-6 alkyl)C(═O)O(C1-6 alkyl), NHC(═O)NH2, NHC(═O)NH(C1-6 alkyl), NHC(═O)N(C1-6 alkyl)2, NHS(═O)(C1-6 alkyl), N(C1-6 alkyl)S(═O)(C1-6 alkyl), NHS(═O)2(C1-6 alkyl), N(C1-6 alkyl)S(═O)2(C1-6 alkyl), NHS(═O)2NH2, NHS(═O)2NH(C1-6 alkyl), NHS(═O)2N(C1-6 alkyl)2, S(═O)(C1-6 alkyl), S(═O)NH2, S(═O)NH(C1-6 alkyl), S(═O)N(C1-6 alkyl)2, S(═O)2(C1-6 alkyl), S(═O)2NH2, S(═O)2NH(C1-6 alkyl), and S(═O)2N(C1-6 alkyl)2.In some embodiments, R2 is C1-6 alkyl, which is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, and NRcS(═O)2Rb; wherein each Ra and Rc are independently selected from H and C1-3 alkyl; and each Rb is independently selected from C1-3 alkyl.", "In some embodiments, R2 is H or C1-6 alkyl, wherein said C1-6 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, NRcRd, NRcC(═O)Rb, and NRcS(═O)2Rb; wherein each Ra, Rc, and Rd are independently selected from H and C1-3 alkyl; and each Rb is independently selected from C1-3 alkyl.", "In some embodiments, R2 is H, methyl, ethyl, propyl, or isopropyl, wherein said methyl, ethyl, propyl, or isopropyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, NRcRd, NRcC(═O)Rb, and NRcS(═O)2Rb; wherein each Ra, Rc, and Rd are independently selected from H, methyl, and ethyl; and each Rb is independently selected from methyl and ethyl.", "In some embodiments, R2 is methyl or ethyl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, and NRcS(═O)2Rb; wherein each Ra and R are independently selected from H, methyl, and ethyl; and each Rb is independently selected from methyl and ethyl.", "In some embodiments, R2 is cyclopropyl or an azetidine ring, each of which is optionally substituted with 1, 2, or 3 independently selected R21 groups.", "In some embodiments, each R21 is independently C1-3 alkyl.", "In some embodiments: R2 is H, methyl, ethyl, propyl, or isopropyl, wherein said methyl, ethyl, propyl, or isopropyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, NRcRd, NRcC(═O)Rb, and NRcS(═O)2Rb; wherein each Ra, Rc, and Rd are independently selected from H, methyl, and ethyl; and each Rb is independently selected from methyl and ethyl; or alternatively, R2 is cyclopropyl or an azetidine ring, each of which is optionally substituted with 1, 2, or 3 independently selected R21 groups; and each R21 is independently C1-3 alkyl.", "In some embodiments, R2 is —CH2—OH, —CH(CH3)—OH, or —CH2—NHSO2CH3.In some embodiments, R4 is H. In some embodiments, R5 is H. In some embodiments, R3 is selected from Cy4, -Cy4A-Cy5, -Cy4A-Cy5AC6, -Cy4A-Y1-Cy5, -Cy4A-Y1-Cy5A-Cy6, -Cy4A-Cy5A-Y2-Cy6, -Cy4A-Y1-Cy5A-Y2-Cy6, and -Cy4A-Y3-Cy6.In some embodiments: Y1 is Y11, C1-6 alkylene, C1-6 alkylene-Y11, or Y11—C1-6 alkylene; Y2 is Y21, C1-6 alkylene, C1-6 alkylene-Y21, or Y21—C1-6 alkylene; Y3 is C1-6 alkylene-Y31—C1-6 alkylene, C1-6 alkylene-Y31—C1-6 alkylene-Y31, or Y31—C1-6 alkylene-Y31—C1-6 alkylene; and Y11, Y21, and Y31 are each independently selected from O and NRf.", "In some embodiments, R3 is Cy4, -Cy4A-Cy5, or -Cy4A-Y1-Cy5.In some embodiments, R3 is -Cy4A-Cy5 or -Cy4A-Y1-Cy5.In some embodiments, R3 is Cy4 or -Cy4A-Cy5.In some embodiments, R3 is Cy4.In some embodiments, R3 is -Cy4A-Cy5.In some embodiments, R3 is -Cy4A-Cy5A-Cy6.In some embodiments, R3 is -Cy4A-Y1-Cy5.In some embodiments, R3 is -Cy4A-Y1-Cy5; wherein Y is C1-4 alkylene or Y11—C1-4 alkylene; and Y11 is C(═O).", "In some embodiments, R3 is -Cy4A-Y1-Cy5A-Cy6.In some embodiments, R3 is -Cy4A-Cy5A-Y2-Cy6.In some embodiments, R3 is -Cy4A-Y1-Cy5A-Y2-Cy6.In some embodiments, R3 is -Cy4A-Y3-Cy6.In some embodiments, Y1 is Y11, C1-6 alkylene, C1-6 alkylene-Y11, or Y11—C1-6 alkylene.", "In some embodiments, Y2 is Y21, C1-6 alkylene, C1-6 alkylene-Y21, or Y21—C1-6 alkylene.", "In some embodiments, Y3 is C1-6 alkylene-Y31—C1-6 alkylene, C1-6 alkylene-Y31—C1-6 alkylene-Y31, or Y31—C1-6 alkylene-Y31—C1-6 alkylene.", "In some embodiments, Y11, Y21, and Y31 are each independently selected from O and NRf.", "In some embodiments, Cy4 is selected from C6-10 aryl, C3-10 cycloalkyl and 3-10 membered heterocycloalkyl, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, provided said 3-10 membered heterocycloalkyl is not a saturated heterocycloalkyl group having one or more nitrogen ring members.", "In some embodiments, Cy4 is phenyl, cyclohexyl, tetrahydro-2H-pyran ring, a piperidine ring, or a pyrrolidine ring, each which is optionally substituted with 1, 2, 3, or 4 substituents independently selected R31 groups.", "In some embodiments, Cy4 is selected from C3-10 cycloalkyl and 3-10 membered heterocycloalkyl, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, provided said 3-10 membered heterocycloalkyl is not a saturated heterocycloalkyl group having one or more nitrogen ring members.", "In some embodiments, Cy4 is C3-10 cycloalkyl, which is optionally substituted with 1, 2, 3, or 4 independently selected R31 groups.", "In some embodiments, Cy4 is selected from C3-7 cycloalkyl, which is optionally substituted with 1, 2, 3, or 4 independently selected R31 groups.", "In some embodiments, Cy4 is selected from cyclohexyl, each of which is optionally substituted with 1, 2, 3, or 4 independently selected R31 groups.", "In some embodiments, Cy4 is a tetrahydro-2H-pyran ring, which is optionally substituted with 1 or 2 independently selected R31 groups.", "In some embodiments, Cy4 is a cyclohexyl, tetrahydro-2H-pyran ring, or a piperidine ring each which is optionally substituted with 1, 2, 3, or 4 substituents independently selected R31 groups.", "In some embodiments, Cy4 is piperidin-4-yl, which is optionally substituted with 1 or 2 independently selected R31 groups.", "In some embodiments, Cy4A is selected from C3-10 cycloalkylene and 3-10 membered heterocycloalkylene, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, provided said 3-10 membered heterocycloalkylene is not a saturated heterocycloalkylene group having one or more nitrogen ring members.", "In some embodiments, Cy4A is selected from C3-10 cycloalkylene, which is optionally substituted with 1, 2, 3, or 4 independently selected R31 groups.", "In some embodiments, Cy4A is selected from C3-7 cycloalkylene, which is optionally substituted with 1, 2, 3, or 4 independently selected R31 groups.", "In some embodiments, Cy4A is selected from cyclopropylene, cyclobutylene, cyclopentylene, cyclohexylene, and cycloheptylene, each of which is optionally substituted with 1, 2, 3, or 4 independently selected R31 groups.", "In some embodiments, Cy4A is selected from cyclohexylene, each of which is optionally substituted with 1 or 2 independently selected R31 groups.", "In some embodiments, Cy5 is 5-10 membered heteroaryl, which is optionally substituted with 1 or 2 independently selected R32 groups.", "In some embodiments, Cy5 is 1H-1,2,4-triazolyl, which is optionally substituted with 1 or 2 independently selected R32 groups.", "In some embodiments, Cy5 is 1H-1,2,4-triazolyl.", "In some embodiments, Cy5 is C6-10 aryl or 5-10 membered heteroaryl, which are each optionally substituted with 1 or 2 independently selected R32 groups.", "In some embodiments, Cy5 is a pyridine ring, a pyrazole ring, or a triazole ring, each of which is optionally substituted with 1 or 2 independently selected R32 groups.", "In some embodiments, R3 is Cy4, provided that Cy4 is not 3-10 membered saturated heterocycloalkyl having one or more nitrogen ring members; and R2 is selected from H, halo, cyclopropyl, cyclobutyl, an azetidine ring, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkyl-S—, CN, OC(═O)Rb, OC(═O)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, C(═NRe)Rb, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, and C1-6 alkyl-S— are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, NO2, ORa, SRa, C(═O)Rb, C(═O)NRcRd, C(═O)ORa, OC(═O)Rb, OC(═O)NRcRd, C(═NRe)NRcRd, NRcC(═NRe)NRcRd, NRcRd, NRcC(═O)Rb, NRcC(═O)ORa, NRcC(═O)NRcRd, NRcS(═O)Rb, NRcS(═O)2Rb, NRcS(═O)2NRcRd, S(═O)Rb, S(═O)NRcRd, S(═O)2Rb, and S(═O)2NRcRd.", "In some embodiments: each R31 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa2, and NRc2Rd2; wherein said C1-6 alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa2, C(═O)NRc2Rd2, C(═O)ORa2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each Ra2, Rc2, and Rd2 are independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; and each Rb2 is independently selected from C1-6 alkyl and C1-6 haloalkyl.", "In some embodiments: each R31 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa2, C(═O)Rb2, C(═O)ORa2, and NRc2Rd2; wherein said C1-6 alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa2, C(═O)NRc2Rd2, C(═O)ORa2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each Ra2, Rc2, and Rd2 are independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl, and C1-6 haloalkyl are each optionally substituted by 1, 2, or 3 CN; and each Rb2 is independently selected from C1-6 alkyl and C1-6 haloalkyl, which are each optionally substituted by 1, 2, or 3 CN.", "In some embodiments: each R31 is independently selected from CN, OH, F, Cl, C1-4 alkyl, C1-4 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, C1-3 alkylcarbonyl, C1-4 alkoxycarbonyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-4 alkyl, C1-3 alkylcarbonyl, C1-3 alkylamino, and di(C1-3 alkyl)amino are each optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, CN, carbamyl, C1-3 alkylcarbamyl, di(C1-3 alkyl)carbamyl, C1-3 alkylaminosulfonyl, C1-3 alkylsulfonyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino.", "In some embodiments, each R31 is independently selected from CN, OH, F, Cl, C1-3 alkyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-3 alkyl and di(C1-3 alkyl)amino is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, C1-3 alkylaminosulfonyl, and C1-3 alkylsulfonyl.", "In some embodiments: each R32 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa2, and NRc2Rd2; wherein said C1-6 alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OR2, C(═O)NRc2Rd2, C(═O)ORa2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each Ra2, Rc2, and Rd2 are independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; and each Rb2 is independently selected from C1-6 alkyl and C1-6 haloalkyl.", "In some embodiments, each R32 is independently selected from CN, OH, F, Cl, C1-3 alkyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-3 alkyl and di(C1-3 alkyl)amino is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, C1-3 alkylaminosulfonyl, and C1-3 alkylsulfonyl.", "In some embodiments: R2 is C1-6 alkyl, which is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, C1-6 alkoxy, S(C1-6 alkyl), C(═O)(C1-6 alkyl), C(═O)NH2, C(═O)NH(C1-6 alkyl), C(═O)N(C1-6 alkyl)2, C(═O)O(C1-6 alkyl), OC(═O)(C1-6 alkyl), OC(═O)NH2, OC(═O)NH(C1-6 alkyl), OC(═O)N(C1-6 alkyl)2, C(═NH)NH2, C(═NH)NH(C1-6 alkyl), C(═NH)N(C1-6 alkyl)2, NHC(═NH)NH2, NHC(═NH)NH(C1-6 alkyl), NHC(═NH)N(C1-6 alkyl)2, NH2, NH(C1-6 alkyl), N(C1-6 alkyl)2, NHC(═O)(C1-6 alkyl), N(C1-6 alkyl)C(═O) (C1-6 alkyl), NHC(═O)(C1-6 alkyl), NHC(═O)O(C1-6 alkyl), N(C1-6 alkyl)C(═O)O(C1-6 alkyl), NHC(═O)NH2, NHC(═O)NH(C1-6 alkyl), NHC(═O)N(C1-6 alkyl)2, NHS(═O)(C1-6 alkyl), N(C1-6 alkyl)S(═O)(C1-6 alkyl), NHS(═O)2(C1-6 alkyl), N(C1-6 alkyl)S(═O)2(C1-6 alkyl), NHS(═O)2NH2, NHS(═O)2NH(C1-6 alkyl), NHS(═O)2N(C1-6 alkyl)2, S(═O)(C1-6 alkyl), S(═O)NH2, S(═O)NH(C1-6 alkyl), S(═O)N(C1-6alkyl)2, S(═O)2(C1-6 alkyl), S(═O)2NH2, S(═O)2NH(C1-6 alkyl), and S(═O)2N(C1-6 alkyl)2; R3 is Cy4 or -Cy4A-Cy5; Cy4 is selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups; Cy4A is selected from C6-10 arylene, C3-10 cycloalkylene, 5-10 membered heteroarylene, and 3-10 membered heterocycloalkylene, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups; Cy5 is selected from C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R32 groups; each R31 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa2, and NRc2Rd2; wherein said C1-6 alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa2, C(═O)NRc2Rd2, C(═O)ORa2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each R32 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa2, and NRc2Rd2; wherein said C1-6 alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa2, C(═O)NRc2Rd2, C(═O)ORa2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each Ra2, Rc2, and Rd2 are independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; each Rb2 is independently selected from C1-6 alkyl and C1-6 haloalkyl; R4 is H; and R5 is H. In some embodiments: R2 is C1-6 alkyl, which is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, and NRcS(═O)2Rb; wherein each Ra and Rc are independently selected from H and C1-3 alkyl; and each Rb is independently selected from C1-3 alkyl; R3 is Cy4 or -Cy4A-Cy5; Cy4 is selected from C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups; Cy4A is selected from C6-10 arylene, C3-10 cycloalkylene, 5-10 membered heteroarylene, and 3-10 membered heterocycloalkylene, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups; Cy5 is selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R32 groups; each R31 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa2, and NRc2Rd2; wherein said C1-6 alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OR2, C(═O)NRc2Rd2, C(═O)ORa2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each R32 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa2, and NRc2Rd2; wherein said C1-6 alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa2, C(═O)NRc2Rd2, C(═O)ORa2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each Ra2, Rc2, and Rd2 are independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; each Rb2 is independently selected from C1-6 alkyl and C1-6 haloalkyl; R4 is H; and R5 is H. In some embodiments: R2 is C1-6 alkyl, which is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, and NRcS(═O)2Rb; wherein each Ra and Rc are independently selected from H and C1-3 alkyl; and each Rb is independently selected from C1-3 alkyl; R3 is Cy4 or -Cy4A-Cy5; Cy4 is selected from C3-10 cycloalkyl and 3-10 membered heterocycloalkyl, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, provided said 3-10 membered heterocycloalkyl is not a saturated heterocycloalkyl group having one or more nitrogen ring members; Cy4A is selected from C3-10 cycloalkylene and 3-10 membered heterocycloalkylene, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, provided said 3-10 membered heterocycloalkylene is not a saturated heterocycloalkylene group having one or more nitrogen ring members; Cy5 is selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl, wherein said C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 3-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R32 groups; each R31 is independently selected from CN, OH, F, Cl, C1-3 alkyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-3 alkyl and di(C1-3 alkyl)amino is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, C1-3 alkylaminosulfonyl, and C1-3 alkylsulfonyl; each R32 is independently selected from CN, OH, F, Cl, C1-3 alkyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-3 alkyl and di(C1-3 alkyl)amino is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, C1-3 alkylaminosulfonyl, and C1-3 alkylsulfonyl; R4 is H; and R5 is H. In some embodiments: R2 is —CH2—OH, —CH(CH3)—OH, or —CH2—NHSO2CH3; R3 is Cy4 or -Cy4A-Cy5; Cy4 is selected from C3-10 cycloalkyl and 3-10 membered heterocycloalkyl, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, provided said 3-10 membered heterocycloalkyl is not a saturated heterocycloalkyl group having one or more nitrogen ring members; Cy4A is selected from C3-10 cycloalkylene and 3-10 membered heterocycloalkylene, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, provided said 3-10 membered heterocycloalkylene is not a saturated heterocycloalkylene group having one or more nitrogen ring members; Cy5 is selected from 5-10 membered heteroaryl, which is optionally substituted with 1, 2, 3, or 4 independently selected R32 groups; each R31 is independently selected from CN, OH, F, Cl, C1-3 alkyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-3 alkyl and di(C1-3 alkyl)amino is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, C1-3 alkylaminosulfonyl, and C1-3 alkylsulfonyl; each R32 is independently selected from CN, OH, F, Cl, C1-3 alkyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-3 alkyl and di(C1-3 alkyl)amino is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, C1-3 alkylaminosulfonyl, and C1-3 alkylsulfonyl; R4 is H; and R5 is H. In some embodiments: R2 is —CH2—OH, —CH(CH3)—OH, or —CH2—NHSO2CH3; R3 is Cy4; Cy4 is selected from C3-10 cycloalkyl and 3-10 membered heterocycloalkyl, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, provided said 3-10 membered heterocycloalkyl is not a saturated heterocycloalkyl group having one or more nitrogen ring members; each R31 is independently selected from CN, OH, F, Cl, C1-3 alkyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-3 alkyl and di(C1-3 alkyl)amino is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, C1-3 alkylaminosulfonyl, and C1-3 alkylsulfonyl; R4 is H; and R5 is H. In some embodiments: R2 is H, methyl, ethyl, propyl, or isopropyl, wherein said methyl, ethyl, propyl, or isopropyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, NRcRd, NRcC(═O)Rb, and NRcS(═O)2Rb; wherein each Ra, Rc, and Rd are independently selected from H, methyl, and ethyl; and each Rb is independently selected from methyl and ethyl; or alternatively, R2 is cyclopropyl or an azetidine ring, each of which is optionally substituted with 1, 2, or 3 independently selected R21 groups; each R21 is independently C1-3 alkyl; R3 is Cy4, -Cy4A-Cy5, or -Cy4A-Y1-Cy5; Y1 is C1-4 alkylene or Y11—C1-4 alkylene; Y11 is C(═O); Cy4 is selected from C6-10 aryl, C3-10 cycloalkyl, and 3-10 membered heterocycloalkyl, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 group, provided said 3-10 membered heterocycloalkylene is not a saturated heterocycloalkylene group having one or more nitrogen ring members; Cy4A is selected from C3-10 cycloalkylene and 3-10 membered heterocycloalkylene, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, provided said 3-10 membered heterocycloalkylene is not a saturated heterocycloalkylene group having one or more nitrogen ring members; Cy5 is C6-10 aryl or 5-10 membered heteroaryl, which are each optionally substituted with 1 or 2 independently selected R32 groups; each R31 or R32 are each independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa2, C(═O)Rb2, C(═O)ORa2, and NRc2Rd2; wherein said C1-6 alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa2, C(═O)NRc2Rd2, C(═O)ORa2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)2Rb2, NR2S(═O)2NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each Ra2, Rc2, and Rd2 are independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl, and C1-6 haloalkyl are each optionally substituted by 1, 2, or 3 CN; each Rb2 is independently selected from C1-6 alkyl and C1-6 haloalkyl, which are each optionally substituted by 1, 2, or 3 CN; R4 is H; and R5 is H. In some embodiments: R2 is H, methyl, ethyl, propyl, or isopropyl, wherein said methyl, ethyl, propyl, or isopropyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, NRcRd, NRcC(═O)Rb, and NRcS(═O)2Rb; wherein each Ra, Rc, and Rd are independently selected from H, methyl, and ethyl; and each Rb is independently selected from methyl and ethyl; or alternatively, R2 is cyclopropyl or an azetidine ring, each of which is optionally substituted with 1, 2, or 3 independently selected R21 groups; provided that when X1X2X3 is —N═CR2—NR3—, X4 is C, and X5 is C; and Cy4 is unsubstituted or substituted 3-10 membered saturated heterocycloalkylene having one or more nitrogen atoms or Cy4A is unsubstituted or substituted 3-10 membered saturated heterocycloalkylene having one or more nitrogen atoms, then R2 is selected from H, methyl, ethyl, propyl, or isopropyl, wherein said methyl, ethyl, propyl, or isopropyl are each optionally optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, NRcRd, NRcC(═O)Rb, and NRcS(═O)2Rb; wherein each Ra, Rc, and Rd are independently selected from H, methyl, and ethyl; and each Rb is independently selected from methyl and ethyl; each R21 is independently C1-3 alkyl; R3 is Cy4, -Cy4A-Cy5, or -Cy4A-Y1-Cy5; Y1 is C1-4 alkylene, Y11—C1-4 alkylene, or C1-6 alkylene-Y11; Y11 is C(═O) or NHC(═O)O; Cy4 is selected from phenyl, C3-7 cycloalkyl, and 4-6 membered heterocycloalkyl, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 group; Cy4A is selected from C3-7 cycloalkylene and 4-6 membered heterocycloalkylene, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups; Cy5 is phenyl, 4-6 membered heterocycloalkyl, or 5-6 membered heteroaryl, which are each optionally substituted with 1 or 2 independently selected R32 groups; each R31 or R32 are each independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa2, C(═O)Rb2, C(═O)ORa2, and NRc2Rd2; wherein said C1-6 alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa2, C(═O)NRc2Rd2, C(═O)ORa2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa2, NRc2C(═O)NRc2Rd2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each Rb2, Rc2, and Rd2 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, and wherein said C1-6 alkyl, and C1-6 haloalkyl are each optionally substituted by 1, 2, or 3 CN; each Rb2 is independently selected from C1-6 alkyl and C1-6 haloalkyl, which are each optionally substituted by 1, 2, or 3 CN; R4 is H; and R5 is H. In some embodiments: R2 is H, methyl, ethyl, propyl, or isopropyl, wherein said methyl, ethyl, propyl, or isopropyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, NRcRd, NRcC(═O)Rb, and NRcS(═O)2Rb; wherein each Ra, Rc, and Rd are independently selected from H, methyl, and ethyl; and each Rb is independently selected from methyl and ethyl; or alternatively, R2 is cyclopropyl or an azetidine ring, each of which is optionally substituted with 1, 2, or 3 independently selected R21 groups; provided that when X1X2X3 is —N═CR2—NR3—, X4 is C, and X5 is C; and Cy4 is unsubstituted or substituted 3-10 membered saturated heterocycloalkylene having one or more nitrogen atoms or Cy4A is unsubstituted or substituted 3-10 membered saturated heterocycloalkylene having one or more nitrogen atoms, then R2 is selected from H, methyl, ethyl, propyl, or isopropyl, wherein said methyl, ethyl, propyl, or isopropyl are each optionally optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa, NRcRd, NRcC(═O)Rb, and NRcS(═O)2Rb; wherein each Ra, Rc, and Rd are independently selected from H, methyl, and ethyl; and each Rb is independently selected from methyl and ethyl; each R21 is independently C1-3 alkyl; R3 is Cy4, -Cy4A-Cy5, or -Cy4A-Y1-Cy5; Y1 is C1-4 alkylene or Y11—C1-4 alkylene; Y11 is C(═O); Cy4 is selected from C6-10 aryl, C3-10 cycloalkyl, and 3-10 membered heterocycloalkyl, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 group; Cy4A is selected from C3-10 cycloalkylene and 3-10 membered heterocycloalkylene, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups; Cy5 is C6-10 aryl or 5-10 membered heteroaryl, which are each optionally substituted with 1 or 2 independently selected R32 groups; each R31 or R32 are each independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa2, C(═O)Rb2, C(═O)ORa2, and NRc2Rd2; wherein said C1-6 alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, ORa2, C(═O)NRc2Rd2, C(═O)ORa2, NRc2Rd2, NRc2C(═O)Rb2, NRc2C(═O)ORa, NRc2C(═O)NRc2Rd2, NRc2S(═O)2Rb2, NRc2S(═O)2NRc2Rd2, S(═O)2Rb2, and S(═O)2NRc2Rd2; each Ra2, Rc2, and Rd2 are independently selected from H, C1-6 alkyl, and C1-6 haloalkyl, wherein said C1-6 alkyl, and C1-6 haloalkyl are each optionally substituted by 1, 2, or 3 CN; each Rb2 is independently selected from C1-6 alkyl and C1-6 haloalkyl, which are each optionally substituted by 1, 2, or 3 CN; R4 is H; and R5 is H. In some embodiments: R2 is —CH2—OH, —CH(CH3)—OH, or —CH2—NHSO2CH3; R3 is -Cy4A-Cy5; Cy4A is selected from C3-10 cycloalkylene and 3-10 membered heterocycloalkylene, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups, provided said 3-10 membered heterocycloalkylene is not a saturated heterocycloalkylene group having one or more nitrogen ring members; Cy5 is selected from 5-10 membered heteroaryl, which is optionally substituted with 1, 2, 3, or 4 independently selected R32 groups; each R31 is independently selected from CN, OH, F, Cl, C1-3 alkyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-3 alkyl and di(C1-3 alkyl)amino is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, C1-3 alkylaminosulfonyl, and C1-3 alkylsulfonyl; each R32 is independently selected from CN, OH, F, Cl, C1-3 alkyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-3 alkyl and di(C1-3 alkyl)amino is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, C1-3 alkylaminosulfonyl, and C1-3 alkylsulfonyl; R4 is H; and R5 is H. In some embodiments: R2 is —CH2—OH, —CH(CH3)—OH, or —CH2—NHSO2CH3; R3 is Cy4 or -Cy4A-Cy5; Cy4 is selected from cyclohexylene and a 2H-tetrahydrofuran ring, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups; Cy4A is selected from cyclohexylene and a 2H-tetrahydrofuran ring, each of which are optionally substituted with 1, 2, 3, or 4 independently selected R31 groups; Cy5 is selected from 5-10 membered heteroaryl, which is optionally substituted with 1, 2, 3, or 4 independently selected R32 groups; each R31 is independently selected from CN, OH, F, Cl, C1-3 alkyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-3 alkyl and di(C1-3 alkyl)amino is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, C1-3 alkylaminosulfonyl, and C1-3 alkylsulfonyl; each R32 is independently selected from CN, OH, F, Cl, C1-3 alkyl, C1-3 haloalkyl, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino, wherein said C1-3 alkyl and di(C1-3 alkyl)amino is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, C1-3 alkylaminosulfonyl, and C1-3 alkylsulfonyl; R4 is H; and R5 is H. In some embodiments: X1X2X3 is —N═CR2—NR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —CR1═CR2—NR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —CR1R1a—C(═O)—NR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —O—C(═O)—NR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is ═N—CR2═CR3—, X4 is N, X5 is C, and Y is CR4.In some embodiments: X1X2X3 is —N═CR2—NR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —CR1═CR2—NR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —CR1R1a—C(═O)—NR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —O—C(═O)—NR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is ═N—CR2═CR3—, X4 is N, X5 is C, and Y is CR4; or X1X2X3 is —N═N—NR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —NR1—C(═O)—NR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —N═CR2—CR3═, X4 is C, X5 is N, and Y is CR4; or X1X2X3 is —CR1═CR2—CR3═, X4 is C, X5 is N, and Y is CR4; or X1X2X3 is ═N—N═CR3—, X4 is N, X5 is C, and Y is CR4; or X1X2X3 is ═CR1—N═CR3—, X4 is N, X5 is C, and Y is CR4; or X1X2X3 is ═CR1—CR2═CR3—, X4 is N, X5 is C, and Y is CR4; or X1X2X3 is —CR1═N—NR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —O—N═CR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —NR1—N═CR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —S—N═CR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —O—CR2═CR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —S—CR2═CR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is ═N—NR2—CR3—, X4 is C, X5 is C, and Y is CR4; or X1X2X3 is —C(═O)—NR2—CR3—, X4 is C, X5 is C, and Y is CR4.In some embodiments, X1X2X3 is —CR1═CR2—NR3—, X4 is C, and X5 is C. In some embodiments, X1X2X3 is —CR1R1a—C(═O)—NR3—, X4 is C, and X5 is C. In some embodiments, X1X2X3 is —O—C(═O)—NR3—, X4 is C, and X5 is C. In some embodiments, X1X2X3 is ═N—CR2═CR3—, X4 is N, and X5 is C. In some embodiments, the compound is a compound of Formula IIa: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula IIb: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula IIc: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula IId: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula IIe: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula IIf: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula IIIa: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula IIIb: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula IIIc: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of any one of Formulas IV-1 to IV-18: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of any one of Formula IV-19 to IV-28: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula V: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula VI: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula VII: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula VIII: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula IX: or a pharmaceutically acceptable salt thereof.", "In some embodiments, the compound is a compound of Formula X: or a pharmaceutically acceptable salt thereof.", "It is further appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, can also be provided in combination in a single embodiment (while the embodiments are intended to be combined as if written in multiply dependent form).", "Conversely, various features of the invention which are, for brevity, described in the context of a single embodiment, can also be provided separately or in any suitable subcombination.", "At various places in the present specification, substituents of compounds of the invention are disclosed in groups or in ranges.", "It is specifically intended that the invention include each and every individual subcombination of the members of such groups and ranges.", "For example, the term “C1-6 alkyl” is specifically intended to individually disclose methyl, ethyl, C3 alkyl, C4 alkyl, C5 alkyl, and C6 alkyl.", "At various places in the present specification, linking substituents are described.", "Where the structure clearly requires a linking group, the Markush variables listed for that group are understood to be linking groups.", "For example, if the structure requires a linking group and the Markush group definition for that variable lists “alkyl” or “aryl” then it is to be understood that the “alkyl” or “aryl” represents a linking alkylene group or arylene group, respectively.", "At various places in the present specification, rings are described (e.g., “a piperidine ring”).", "Unless otherwise specified, these rings can be attached to the rest of the molecule at any ring member as permitted by valency.", "For example, the term “a 2H-tetrahydropyran ring” may refer to a 2H-tetrahydropyran-2-yl, 2H-tetrahydropyran-3-yl, 2H-tetrahydropyran-4-yl ring, etc.", "The term “n-membered” where n is an integer typically describes the number of ring-forming atoms in a moiety where the number of ring-forming atoms is n. For example, 2H-tetrahydropyran is an example of a 6-membered heterocycloalkyl ring, 1H-1,2,4-triazole is an example of a 5-membered heteroaryl ring, pyridine is an example of a 6-membered heteroaryl ring, and 1,2,3,4-tetrahydro-naphthalene is an example of a 10-membered cycloalkyl group.", "For compounds of the invention in which a variable appears more than once, each variable can be a different moiety independently selected from the group defining the variable.", "For example, where a structure is described having two R groups that are simultaneously present on the same compound, the two R groups can represent different moieties independently selected from the group defined for R. In another example, when an optionally multiple substituent is designated in the form: then it is to be understood that substituent R can occur p number of times on the ring, and R can be a different moiety at each occurrence.", "It is to be understood that each R group may replace any hydrogen atom attached to a ring atom, including one or both of the (CH2)n hydrogen atoms.", "Further, in the above example, should the variable Q be defined to include hydrogens, such as when Q is said to be CH2, NH, etc., any floating substituent such as R in the above example, can replace a hydrogen of the Q variable as well as a hydrogen in any other non-variable component of the ring.", "As used herein, the phrase “optionally substituted” means unsubstituted or substituted.", "As used herein, the term “substituted” means that a hydrogen atom is removed and replaced by a substituent.", "It is to be understood that substitution at a given atom is limited by valency.", "As used herein, the term “Cn-m alkyl”, employed alone or in combination with other terms, refers to a saturated hydrocarbon group that may be straight-chain or branched, having n to m carbon atoms.", "In some embodiments, the alkyl group contains 1 to 6, 1 to 4 or 1 to 3 carbon atoms.", "Examples of alkyl moieties include, but are not limited to, chemical groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, 2-methyl-1-butyl, 3-pentyl, n-hexyl, 1,2,2-trimethylpropyl, and the like.", "As used herein, the term “alkylene”, employed alone or in combination with other terms, refers to a divalent alkyl linking group, which can be branched or straight-chain, where the two substituents may be attached any position of the alkylene linking group.", "Examples of alkylene groups include, but are not limited to, ethan-1,2-diyl, propan-1,3-diyl, propan-1,2-diyl, butan-1,4-diyl, butan-1,3-diyl, butan-1,2-diyl, 2-methyl-propan-1,3-diyl, and the like.", "As used herein, “Cn-m alkenyl” refers to an alkyl group having one or more double carbon-carbon bonds and having n to m carbons.", "In some embodiments, the alkenyl moiety contains 2 to 6, 2 to 4, or 2 to 3 carbon atoms.", "Example alkenyl groups include, but are not limited to, ethenyl, n-propenyl, isopropenyl, n-butenyl, sec-butenyl, and the like.", "As used herein, “Cn-m alkynyl” refers to an alkyl group having one or more triple carbon-carbon bonds and having n to m carbons.", "Example alkynyl groups include, but are not limited to, ethynyl, propyn-1-yl, propyn-2-yl, and the like.", "In some embodiments, the alkynyl moiety contains 2 to 6, 2 to 4, or 2 to 3 carbon atoms.", "As used herein, the term “alkenylene”, employed alone or in combination with other terms, refers to a divalent alkenyl linking group, which can be branched or straight-chain, where the two substituents may be attached any position of the alkenylene linking group.", "As used herein, the term “alkynylene”, employed alone or in combination with other terms, refers to a divalent alkynyl linking group, which can be branched or straight-chain, where the two substituents may be attached any position of the alkynylene linking group.", "As used herein, the term “C1-3 alkoxy”, employed alone or in combination with other terms, refers to a group of formula —O-alkyl, wherein the alkyl group has 1 to 3 carbons.", "Example alkoxy groups include methoxy, ethoxy, and propoxy (e.g., n-propoxy and isopropoxy).", "As used herein, the term “amino” refers to a group of formula —NH2.As used herein, the term “C1-3 alkylamino” refers to a group of formula —NH(alkyl), wherein the alkyl group 1 to 3 carbon atoms.", "As used herein, the term “di(C1-3-alkyl)amino” refers to a group of formula —N(alkyl)2, wherein the two alkyl groups each has, independently, 1 to 3 carbon atoms.", "As used herein, the term “C1-4 alkoxycarbonyl” refers to a group of formula —C(O)O— alkyl, wherein the alkyl group has 1 to 4 carbon atoms.", "As used herein, the term “C1-3 alkylcarbonyl” refers to a group of formula —C(O)-alkyl, wherein the alkyl group has 1 to 3 carbon atoms.", "As used herein, the term “carboxy” refers to a group of formula —C(O)OH.", "As used herein, the term “thio” refers to a group of formula —SH.", "As used herein, the term “C1-3 alkylthio” refers to a group of formula —S—(C1-3 alkyl).", "As used herein, the term “C1-3 alkylsulfinyl” refers to a group of formula —S(O)-alkyl, wherein the alkyl group has 1 to 3 carbon atoms.", "As used herein, the term “C1-3 alkylsulfonyl” refers to a group of formula —S(O)2-alkyl, wherein the alkyl group has 1 to 3 carbon atoms.", "As used herein, the term “C1-3 alkylcarbonyloxy” refers to a group of formula —OC(O)— alkyl, wherein the alkyl group has 1 to 3 carbon atoms.", "As used herein, the term “C1-3 alkylcarbonylamino” refers to a group of formula —NHC(O)-alkyl, wherein the alkyl group has 1 to 3 carbon atoms.", "As used herein, the term “aminocarbonylamino” refers to a group of formula —NHC(O)NH2.As used herein, the term “C1-3 alkylaminocarbonylamino,” refers to a group of formula —NHC(O)NH(alkyl), wherein said alkyl has 1 to 3 carbon atoms.", "As used herein, the term “di(C1-3 alkylaminocarbonylamino” refers to a group of formula —NHC(O)N(alkyl)2, wherein each alkyl independently has 1 to 3 carbon atoms.", "As used herein, the term “carbamyl” refers to a group of formula —C(O)—NH2.As used herein, the term “C1-3 alkylcarbamyl” refers to a group of formula —C(O)—NH(alkyl), wherein the alkyl group has 1 to 3 carbon atoms.", "As used herein, the term “di(C1-3-alkyl)carbamyl” refers to a group of formula —C(O)N(alkyl)2, wherein the two alkyl groups each has, independently, 1 to 3 carbon atoms.", "As used herein, the term “C1-3 alkylsulfonylamino” refers to a group of formula —NHS(O)2-alkyl, wherein said alkyl has 1 to 3 carbon atoms.", "As used herein, the term “aminosulfonyl” refers to a group of formula —S(O)2NH2.As used herein, the term “C1-3 alkylaminosulfonyl” refers to a group of formula —S(O)2NH(alkyl), wherein said alkyl has 1 to 3 carbon atoms.", "As used herein, the term “di(C1-3 alkyl)aminosulfonyl” refers to a group of formula —S(O)2N(alkyl)2, wherein each alkyl independently has 1 to 3 carbon atoms.", "As used herein, the term “aminosulfonylamino” refers to a group of formula —NHS(O)2NH2.As used herein, the term “C1-3 alkylaminosulfonylamino,” refers to a group of formula —NHS(O)2NH(alkyl), wherein said alkyl has 1 to 3 carbon atoms.", "As used herein, the term “di(C1-3 alkylaminosulfonylamino” refers to a group of formula —NHS(O)2N(alkyl)2, wherein each alkyl independently has 1 to 3 carbon atoms.", "As used herein, the term “HO—Cn-m-alkyl” refers to a group of formula -alkylene-OH, wherein said alkylene group has n to m carbon atoms.", "In some embodiments, the alkylene group has 1 to 3 carbon atoms.", "As used herein, the term “Co-p alkoxy-Cn-m-alkyl” refers to a group of formula -alkylene-O-alkyl, wherein said alkylene group has n to m carbon atoms and said alkyl group has o to p carbon atoms.", "In some embodiments, the alkyl and alkylene groups each independently have 1 to 3 carbon atoms.", "As used herein, the term “carbonyl”, employed alone or in combination with other terms, refers to a —C(O)— group.", "As used herein, “halo” or “halogen”, employed alone or in combination with other terms, includes fluoro, chloro, bromo, and iodo.", "As used herein, the term “Cn-m haloalkyl”, employed alone or in combination with other terms, refers to an Cn-m alkyl group having up to {2(n to m)+1} halogen atoms which may either be the same or different.", "In some embodiments, the halogen atoms are fluoro atoms.", "In some embodiments, the alkyl group has 1 to 6 or 1 to 4 carbon atoms.", "Example haloalkyl groups include CF3, C2F5, CHF2, CCl3, CHCl2, C2Cl5, and the like.", "In some embodiments, the haloalkyl group is a fluoroalkyl group.", "As used herein, “Cn-m haloalkoxy” refers to a group of formula —O-haloalkyl having n to m carbon atoms.", "An example haloalkoxy group is OCF3.In some embodiments, the haloalkoxy group is fluorinated only.", "In some embodiments, the alkyl group has 1 to 6 or 1 to 4 carbon atoms.", "As used herein, the term “cyano-Cn-m alkyl” refers to a Cn-m alkyl substituted by a cyano group.", "In some embodiments, the alkyl group has 1 to 3 carbon atoms.", "As used herein, the appearance of the term “monocyclic” before the name of a moiety indicates that the moiety has a single ring.", "As used herein, the term “cycloalkyl”, employed alone or in combination with other terms, refers to a non-aromatic cyclic hydrocarbon moiety, which may optionally contain one or more alkenylene groups as part of the ring structure.", "Cycloalkyl groups can include mono- or polycyclic (e.g., having 2, 3 or 4 fused, spirocyclic, or bridged rings) ring systems.", "Also included in the definition of cycloalkyl are moieties that have one or more aromatic rings fused (i.e., having a bond in common with) to the cycloalkyl ring, for example, benzo derivatives of cyclopentane, cyclopentene, cyclohexane, and the like.", "One or more ring-forming carbon atoms of a cycloalkyl group can be oxidized to form carbonyl linkages.", "In some embodiments, cycloalkyl is a 3-10 membered cycloalkyl, which is monocyclic or bicyclic.", "In some embodiments, cycloalkyl is a 3-6 or 3-7 monocyclic cycloalkyl.", "Exemplary cycloalkyl groups include 1,2,3,4-tetrahydro-naphthalene, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cyclohexadienyl, cycloheptatrienyl, norbornyl, norpinyl, norcarnyl, adamantyl, and the like.", "In some embodiments, the cycloalkyl group is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl.", "As used herein, the term “aryl”, employed alone or in combination with other terms, refers to a monocyclic or polycyclic (e.g., having 2, 3 or 4 fused rings) aromatic hydrocarbon, such as, but not limited to, phenyl, 1-naphthyl, 2-naphthyl, anthracenyl, phenanthrenyl, and the like.", "In some embodiments, aryl is C6-10 aryl.", "In some embodiments, the aryl group is a naphthalene ring or phenyl ring.", "In some embodiments, the aryl group is phenyl.", "As used herein, the term “heteroaryl”, employed alone or in combination with other terms, refers to a monocyclic or polycyclic (e.g., having 2, 3 or 4 fused rings) aromatic hydrocarbon moiety, having one or more heteroatom ring members selected from nitrogen, sulfur and oxygen.", "In some embodiments, heteroaryl is a 5-10 membered heteroaryl, which is monocyclic or bicyclic, comprising 1 to 9 carbon atoms and 1, 2, 3, or 4 heteroatom ring members independently selected from nitrogen, sulfur and oxygen.", "In some embodiments, heteroaryl is a 5-6 membered heteroaryl, which is monocyclic or bicyclic, comprising 1 to 5 carbon atoms and 1, 2, 3, or 4 heteroatom ring members independently selected from nitrogen, sulfur, and oxygen.", "When the heteroaryl group contains more than one heteroatom ring member, the heteroatoms may be the same or different.", "Example heteroaryl groups include, but are not limited to, pyridine, pyrimidine, pyrazine, pyridazine, pyrrole, pyrazole, azolyl, oxazole, thiazole, imidazole, furan, thiophene, quinoline, isoquinoline, indole, benzothiophene, benzofuran, benzisoxazole, imidazo[1,2-b]thiazole, purine, or the like.", "A five-membered ring heteroaryl is a heteroaryl with a ring having five ring atoms wherein one or more (e.g., 1, 2, or 3) ring atoms are independently selected from N, O, and S. Exemplary five-membered ring heteroaryls are thienyl, furyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, pyrazolyl, isothiazolyl, isoxazolyl, 1,2,3-triazolyl, tetrazolyl, 1,2,3-thiadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-triazolyl, 1,2,4-thiadiazolyl, 1,2,4-oxadiazolyl, 1,3,4-triazolyl, 1,3,4-thiadiazolyl, and 1,3,4-oxadiazolyl.", "A six-membered ring heteroaryl is a heteroaryl with a ring having six ring atoms wherein one or more (e.g., 1, 2, or 3) ring atoms are independently selected from N, O, and S. Exemplary six-membered ring heteroaryls are pyridyl, pyrazinyl, pyrimidinyl, triazinyl and pyridazinyl.", "As used herein, the term “heteroarylalkyl” refers to a group of formula -alkylene-heteroaryl.", "In some embodiments, heteroarylalkyl is C1-9 heteroaryl-C1-3 alkyl, wherein the heteroaryl portion is monocyclic or bicyclic and has 1, 2, 3, or 4 heteroatom ring members independently selected from nitrogen, sulfur and oxygen.", "As used herein, the term “heterocycloalkyl”, employed alone or in combination with other terms, refers to non-aromatic ring system, which may optionally contain one or more alkenylene or alkynylene groups as part of the ring structure, and which has at least one heteroatom ring member independently selected from nitrogen, sulfur and oxygen.", "When the heterocycloalkyl groups contains more than one heteroatom, the heteroatoms may be the same or different.", "Heterocycloalkyl groups can include mono- or polycyclic (e.g., having 2, 3 or 4 fused, spirocyclic, or bridged rings) ring systems.", "Also included in the definition of heterocycloalkyl are moieties that have one or more aromatic rings fused (i.e., having a bond in common with) to the non-aromatic ring, for example, 1,2,3,4-tetrahydro-quinoline and the like.", "The carbon atoms or heteroatoms in the ring(s) of the heterocycloalkyl group can be oxidized to form a carbonyl, or sulfonyl group (or other oxidized linkage) or a nitrogen atom can be quaternized.", "In some embodiments, heterocycloalkyl is 5-10 membered heterocycloalkyl, which is monocyclic or bicyclic, comprising 2 to 9 carbon atoms and 1, 2, 3, or 4 heteroatom ring members independently selected from nitrogen, sulfur, and oxygen.", "Examples of heterocycloalkyl groups include 1,2,3,4-tetrahydro-quinoline, azetidine, azepane, pyrrolidine, piperidine, piperazine, morpholine, thiomorpholine, pyran, and a 2-oxo-1,3-oxazolidine ring.", "As used herein, the term “heterocycloalkylalkyl” refers to a group of formula -alkylene-heterocycloalkyl.", "In some embodiments, heterocycloalkylalkyl is C2-9 heterocycloalkyl-C1-3 alkyl, wherein the heterocycloalkyl portion is monocyclic or bicyclic and has 1, 2, 3, or 4 heteroatom ring members independently selected from nitrogen, sulfur and oxygen.", "The compounds described herein can be asymmetric (e.g., having one or more stereocenters).", "All stereoisomers, such as enantiomers and diastereomers, are intended unless otherwise indicated.", "Compounds of the present invention that contain asymmetrically substituted carbon atoms can be isolated in optically active or racemic forms.", "Methods on how to prepare optically active forms from optically inactive starting materials are known in the art, such as by resolution of racemic mixtures or by stereoselective synthesis.", "Many geometric isomers of olefins, C═N double bonds, and the like can also be present in the compounds described herein, and all such stable isomers are contemplated in the present invention.", "Cis and trans geometric isomers of the compounds of the present invention are described and may be isolated as a mixture of isomers or as separated isomeric forms.", "Resolution of racemic mixtures of compounds can be carried out by any of numerous methods known in the art.", "An example method includes fractional recrystallization using a chiral resolving acid which is an optically active, salt-forming organic acid.", "Suitable resolving agents for fractional recrystallization methods are, for example, optically active acids, such as the D and L forms of tartaric acid, diacetyltartaric acid, dibenzoyltartaric acid, mandelic acid, malic acid, lactic acid or the various optically active camphorsulfonic acids such as β-camphorsulfonic acid.", "Other resolving agents suitable for fractional crystallization methods include stereoisomerically pure forms of α-methylbenzylamine (e.g., S and R forms, or diastereomerically pure forms), 2-phenylglycinol, norephedrine, ephedrine, N-methylephedrine, cyclohexylethylamine, 1,2-diaminocyclohexane, and the like.", "Resolution of racemic mixtures can also be carried out by elution on a column packed with an optically active resolving agent (e.g., dinitrobenzoylphenylglycine).", "Suitable elution solvent composition can be determined by one skilled in the art.", "Compounds of the invention also include tautomeric forms.", "Tautomeric forms result from the swapping of a single bond with an adjacent double bond together with the concomitant migration of a proton.", "Tautomeric forms include prototropic tautomers which are isomeric protonation states having the same empirical formula and total charge.", "Example prototropic tautomers include ketone-enol pairs, amide-imidic acid pairs, lactam-lactim pairs, enamine-imine pairs, and annular forms where a proton can occupy two or more positions of a heterocyclic system, for example, 1H- and 3H-imidazole, 1H-, 2H- and 4H-1,2,4-triazole, 1H- and 2H-isoindole, and 1H- and 2H-pyrazole.", "Tautomeric forms can be in equilibrium or sterically locked into one form by appropriate substitution.", "Compounds of the invention can also include all isotopes of atoms occurring in the intermediates or final compounds.", "Isotopes include those atoms having the same atomic number but different mass numbers.", "For example, isotopes of hydrogen include tritium and deuterium.", "In some embodiments, 1, 2, or 3 CH2 groups in the azetidine ring of Formula I are replaced by a CHD or CD2 group.", "In some embodiments, 1, 2, or 3 CH2 or CH groups in the piperidine ring of Formula I are replaced by a CHD, CD2 or CD group, respectively.", "In some embodiments, 1, 2, 3, 4, or 5 CH2 or CH groups in the piperidine ring of Formula I are replaced by a CHD, CD2 or CD group, respectively.", "The term, “compound,” as used herein is meant to include all stereoisomers, geometric isomers, tautomers, and isotopes of the structures depicted.", "All compounds, and pharmaceutically acceptable salts thereof, can be found together with other substances such as water and solvents (e.g., hydrates and solvates) or can be isolated.", "In some embodiments, the compounds of the invention, or salts thereof, are substantially isolated.", "By “substantially isolated” is meant that the compound is at least partially or substantially separated from the environment in which it was formed or detected.", "Partial separation can include, for example, a composition enriched in the compounds of the invention.", "Substantial separation can include compositions containing at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 95%, at least about 97%, or at least about 99% by weight of the compounds of the invention, or salt thereof.", "Methods for isolating compounds and their salts are routine in the art.", "The phrase “pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio.", "The expressions, “ambient temperature” and “room temperature,” as used herein, are understood in the art, and refer generally to a temperature, e.g.", "a reaction temperature, that is about the temperature of the room in which the reaction is carried out, for example, a temperature from about 20° C. to about 30° C. The present invention also includes pharmaceutically acceptable salts of the compounds described herein.", "As used herein, “pharmaceutically acceptable salts” refers to derivatives of the disclosed compounds wherein the parent compound is modified by converting an existing acid or base moiety to its salt form.", "Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; alkali or organic salts of acidic residues such as carboxylic acids; and the like.", "The pharmaceutically acceptable salts of the present invention include the non-toxic salts of the parent compound formed, for example, from non-toxic inorganic or organic acids.", "The pharmaceutically acceptable salts of the present invention can be synthesized from the parent compound which contains a basic or acidic moiety by conventional chemical methods.", "Generally, such salts can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, non-aqueous media like ether, ethyl acetate, alcohols (e.g., methanol, ethanol, iso-propanol, or butanol) or acetonitrile (ACN) are preferred.", "Lists of suitable salts are found in Remington's Pharmaceutical Sciences, 17th ed., Mack Publishing Company, Easton, Pa., 1985, p. 1418 and Journal of Pharmaceutical Science, 66, 2 (1977), each of which is incorporated herein by reference in its entirety.", "In some embodiments, the compounds described herein include the N-oxide forms.", "Synthesis Compounds of the invention, including salts thereof, can be prepared using known organic synthesis techniques and can be synthesized according to any of numerous possible synthetic routes, such as those in the Schemes below.", "The reactions for preparing compounds of the invention can be carried out in suitable solvents which can be readily selected by one of skill in the art of organic synthesis.", "Suitable solvents can be substantially non-reactive with the starting materials (reactants), the intermediates, or products at the temperatures at which the reactions are carried out, e.g., temperatures which can range from the solvent's freezing temperature to the solvent's boiling temperature.", "A given reaction can be carried out in one solvent or a mixture of more than one solvent.", "Depending on the particular reaction step, suitable solvents for a particular reaction step can be selected by the skilled artisan.", "Preparation of compounds of the invention can involve the protection and deprotection of various chemical groups.", "The need for protection and deprotection, and the selection of appropriate protecting groups, can be readily determined by one skilled in the art.", "The chemistry of protecting groups can be found, for example, in Wuts and Greene, Protective Groups in Organic Synthesis, 4th ed., John Wiley & Sons: New Jersey, (2007), which is incorporated herein by reference in its entirety.", "Reactions can be monitored according to any suitable method known in the art.", "For example, product formation can be monitored by spectroscopic means, such as nuclear magnetic resonance spectroscopy (e.g., 1H or 13C), infrared spectroscopy, spectrophotometry (e.g., UV-visible), mass spectrometry, or by chromatographic methods such as high performance liquid chromatography (HPLC) or thin layer chromatography (TLC).", "Compounds of Formula I can be synthesized by procedures analogous to those in the schemes below.", "When X1—X2—X3 is —N═CR2—NR3—, X4 is C, and X5 is C, compounds of Formula I can be prepared as illustrated in Scheme 1.Appropriately substituted thienopyridines 1 can be subjected to nitration under conditions such as tetrabutylammonium nitrate and trifluoroacetic anhydride in dichloromethane or nitric acid in sulfuric acid to give compounds of formula 2.Reaction of thienopyridinols 2 in heated POCl3 or other suitable chlorination conditions such as POCl3/PCl5 provides the corresponding chlorides 3.Coupling of compounds 3 with an appropriate R3—NH2 in the presence of a suitable base such as diisopropylethylamine affords compounds 4.Reduction of nitro compounds 4 using catalytic hydrogenation conditions with catalyst such as palladium or nickel or using iron or other suitable reducing conditions yields the corresponding diamines 5.Condensation of compounds 5 with an appropriate amide (activated with triethyloxonium tetrafluoroborate) generates the desired compounds 6.The diamine can also react with an appropriate acid R2CO2H under coupling conditions to give an amide intermediate which subsequently can be transformed compounds 6 via an intermolecular condensation.", "The R2 and R3 can be further modified to desired groups.", "Alternatively, the R3 can be further transformed to groups disclosed in the invention via modification on compounds 4 and 5.When X1—X2—X3 is —CR1═CR2—NR3—, X4 is C, and X5 is C, compounds of Formula I can be prepared as illustrated in Scheme 2.Appropriately substituted thienopyridines 1 can react with N-iodosuccinimide to give compounds 7.Reaction of thienopyridinols 7 in heated POCl3 or other suitable chlorination conditions such as POCl3/PCl5 provides the corresponding chlorides 8.Reaction of the iodo compounds 8 with an appropriate alkyne compound catalyzed by a suitable palladium and copper catalyst such as bis(triphenylphosphine)palladium(II) chloride and copper(I) iodide affords compounds 9.Condensation of 9 with R3—NH2 in the presence of suitable coupling conditions such as palladium acetate, (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) and cesium carbonate in toluene generates an amine coupling intermediate which cyclizes in situ with alkyne to furnish compounds of formula 10.The substitution R2 can be introduced by halogenation, nitration or nucleophilic addition of the pyrole ring.", "Further modifications of R1, R2, R3, R4, and R5 can be achieved in each step using methods known to one skilled in the art.", "When X1—X2—X3 is —O—C(O)—NR3—, X4 is C, and X5 is C, compounds of Formula I can be prepared as illustrated in Scheme 3.Thienopyridines 11 can be reacted with NaOCl to yield the corresponding chlorinated compounds 12.Alternatively, 11 can be converted to N-oxide which subsequently can be converted to 12 in the HCl or POCl3 conditions.", "Protection of the hydroxyl group in 12 using conditions known to one skilled in the art gives ether compound 13.Reaction 13 with R3NH2 under coupling conditions such as palladium acetate, (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) and cesium carbonate in toluene can generate compounds 14.Deprotection of 14 with boron tribromide gives compounds 15.Treatment of 15 with triphosgene or carbonyl diimidazole then provides compounds of formula 16.When X1—X2—X3 is ═N—CR2═CR3—, X4 is N, and X5 is C, compounds of Formula I can be prepared as illustrated in Scheme 4.Reaction of thienopyrazines 17 with hydrogen peroxide in acetic acid gives an N-oxide intermediate which upon treatment with phosphorous oxychloride provides compounds 18.Substitution of chloride with Boc-NH2 under Buchwald conditions yields compounds 19.Alkylation of carbamates 19 with appropriately substituted 2-halomethyl ketone [halo-CH2C(O)R3] by methods known to one skilled in the art gives compounds 20.The later can be further converted to corresponding substituted compounds 21 under standard alkylation or aldo-condensation conditions if necessary.", "The deprotection of 21 to 22 can be accomplished using conditions such as trifluoroacetic acid in dichloromethane or HCl in dioxane.", "Cyclization of 22 to compounds 23 can be accomplished by methods known to one skilled in the art, for example treatment with trifluoroacetic anhydride and trifluoroacetic acid mixture.", "Further functionalization of R2, R3, R4, R5 can be performed, if desired, using reactions know to one skilled in the art (for example, Larock, R. C. Comprehensive Organic Transformation).", "Alternatively, compounds of formula 23 can be synthesized as shown in Scheme 5.Compounds 19 from Scheme 4 can be treated with trifluoroacetic acid or HCl in dioxane to give deprotected compounds 24.Condensation of 24 with alpha-halo-ketone in the presence of a suitable base then affords the desired compounds 23.When X1—X2—X3 is —N═N—NR3—, X4 is C, and X5 is C, compounds of Formula I can be prepared by reacting compounds 5 from Scheme 1 with a diazoniation reagent such as butyl nitrite in the presence of copper(II) bromide, as illustrated in Scheme 6.When X1—X2—X3 is —N═CR2—CR3═, X4 is C, and X5 is N, compounds of formula I can be prepared as illustrated in Scheme 7.Tribromopyrazoles 28 can be protected with a suitable protective group such as SEM to give corresponding compounds 29.Lithium-halogen exchange of 29 with butyl lithium then quenched with a suitable alkylation reagent (for example R2-halo) or electrophile (for example an aldehyde) provides compounds 30.Reaction of 30 with a lithium reagent such as butyl lithium followed by aqueous work up affords monobromo-pyrazoles 31.Suzuki reaction of 31 with borates 27 (prepared from bromide 26 by reacting with pinacol borate in the presence of a suitable palladium catalyst) can give coupling compounds 32.Bromination of 32 can yield compounds 33, which can be reduced with iron to provide amines 34.Deprotection of SEM can be achieved using methods known to one skilled in the art, such as reacting with trifluoroacetic acid followed by treatment with ammonium hydroxide.", "Condensation of 35 with ortho esters then generates tricyclic compounds 36.The later can be subjected to coupling conditions such as Suzuki coupling conditions to provide compounds of formula 37.Further modifications of substitutions, if desired, may be performed by methods known by one skilled in the art.", "When X1—X2—X3 is ═N—N═CR3—, X4 is N, and X5 is C, compounds of Formula I can be prepared as illustrated in Scheme 8.Substituted hydrazines 38 can be prepared by reaction of compounds 18 with an appropriately protected hydrazine (for example Boc-NHNH2) under Buchwald-Hartwig amination conditions.", "Deprotection of compounds 38 can be performed using conditions such as those described in Greene, T. W. and Wats, P. G. M. “Protective Groups in Organic Synthesis, 3rd Edition”, 1999, Wiley-Interscience.", "For example when P is Boc, compounds 38 can be deprotected to 39 by treatment with trifluoroacetic acid or HCl in dioxane.", "The formation of hydrazides 40 from 39 may be accomplished by a variety of methods known to one skilled in the art, such as standard peptide coupling methods.", "The hydrazides 40 can be cyclized to compounds of formula 41 by reacting with POCl3 or with thionyl chloride in the presence of a suitable base (for example triethylamine).", "When X1—X2—X3 is ═CR1—N═CR3—, X4 is N, and X5 is C, compounds of Formula I can be prepared as illustrated in Scheme 9.Thienopyrazines 18 can be converted to cyano compounds 42 via Pd-mediated cyanation, such as zinc cyanide in the presence of palladium(II) trifluoroacetate and racemic-2-(di-tert-butylphosphino)-1,1′-binapthyl.", "Subsequent reduction of nitriles 42 gives amines 43 using well known conditions such as palladium catalyzed hydrogenation in the presence of HCl.", "The coupling of amines 43 with acids R3CO2H can be achieved under standard amide coupling conditions such as HATU/diisopropylethylamine.", "Cyclization of amides 44 to the tricyclic compounds of formula 45 can be accomplished by conversion to the corresponding thioamide (by reacting with Lawesson's reagent, for example) followed by treatment with an activating agent (such as a mercury salt, a silver salt or a copper salt).", "When X1—X2—X3 is —NR1—N═CR3—, X4 is C, and X5 is C, compounds of Formula I can be prepared as illustrated in Scheme 10.Commercially available chlorothieopyridines 46 can be converted to the corresponding iodo analogs 47 through treatment with sodium iodide at elevated temperature.", "Reaction iodothienopyridines 47 with butyl lithium or other metal reagents followed by treatment with a suitable aldehyde R3CHO provides alcohols 48.Preparation of ketones 49 can be accomplished by treating 48 with an oxidizing agent such as Dess-Martin periodinane.", "Ketones 49 can then be transformed to hydrazones 50 through reaction with hydrazine.", "Cyclization of hydrazones 50 to tricyclic compounds 51 can be achieved via an intramolecular Buchwald-Hartwig cyclization.", "Compounds 51 can be converted to compounds of formula 52 by reacting of 51 with an alkylating reagent such as R1-halogen or R1—OMs/R1—OTs in the presence of a base such as DBU.", "Alternatively, compounds of formula 53 (Formula I, when X1—X2—X3 is ═N—NR2—CR3═, X4 is C, and X5 is C) can be prepared by treating 51 with an alkylating reagent R2-leaving group (leaving group is halo, OTs, OMs, OTf, etc.)", "in the presence of a suitable base such as sodium hydride.", "When X1—X2—X3 is —O═CR2═CR3—, X4 is C, and X5 is C, compounds of Formula I can be prepared as illustrated in Scheme 11.Compounds 49 from Scheme 10 can be reacted with glycolic acid ester under Buchwald-Hartwig coupling conditions to generate compounds 54.Cyclization of 54 under basic conditions such as potassium tert-butoxide can provide tricyclic compounds 55.Further functionalization of the substitutions on 55 can be performed, in desired, using reactions known to one skilled in the art.", "For example, the esters 55 can be hydrolyzed to acids 56, which can then be transformed to amides 57 under standard coupling conditions such as BOP or HATU coupling.", "Reaction of amides 57 with a nucleophile such as methyl magnesium bromide affords ketones 58, which can then be reduced to give compounds of formula 59.When X1—X2—X3 is —S═CR2═CR3—, X4 is C, and X5 is C, compounds of Formula I can be prepared in analogy to the methods illustrated in Scheme 11, with thioglycolic ester replacing glycolic ester.", "When Y is N, X1—X2—X3 is —N═CR2—NR3—, X4 is C, and X5 is C, compounds of formula I of the invention can be prepared as illustrated in Scheme 12.Appropriately substituted fluoropyridines 60 can be reacted with a thiol such as benzylthiol in the presence of a suitable base such as sodium tert-butoxide to give compounds of formula 61.Reaction of pyridine thioethers 61 with sulfuryl chloride followed by treatment with ammonia provides cyclized products 62.Alternatively, compounds 62 can be synthesized by reacting compounds 60 with hydroxylamine and sulfur.", "Nitration of compounds 63 gives compounds of formula 64.Coupling of compounds 64 with an appropriate R3—NH2 in the presence of a suitable base such as diisopropylethylamine affords compounds 65.Reduction of nitro compounds 65 using catalytic hydrogenation conditions with catalyst such as palladium or nickel or using iron or other suitable reducing conditions yields the corresponding diamines 66.Condensation of compounds 66 with an appropriate amide (activated with triethyloxonium tetrafluoroborate) generates the desired compounds 67.The diamine can also react with an appropriate acid R2CO2H under coupling conditions to give an amide intermediate which subsequently can be transformed compounds 67 via an intermolecular condensation.", "The R2 and R3 can be further modified to desired groups.", "Alternatively, R3 can be further transformed to groups disclosed in the invention via modification on compounds 65 and 66.Methods Compounds of the invention are JAK inhibitors, and the majority of the compounds of the invention, are JAK1 selective inhibitors.", "A JAK1 selective inhibitor is a compound that inhibits JAK1 activity preferentially over other Janus kinases.", "For example, the compounds of the invention preferentially inhibit JAK1 over one or more of JAK2, JAK3, and TYK2.In some embodiments, the compounds inhibit JAK1 preferentially over JAK2 (e.g., have a JAK1/JAK2 IC50 ratio >1).", "In some embodiments, the compounds are about 10-fold more selective for JAK1 over JAK2.In some embodiments, the compounds are about 3-fold, about 5-fold, about 10-fold, about 15-fold, or about 20-fold more selective for JAK1 over JAK2 as calculated by measuring IC50 at 1 mM ATP (e.g., see Example A).", "JAK1 plays a central role in a number of cytokine and growth factor signaling pathways that, when dysregulated, can result in or contribute to disease states.", "For example, IL-6 levels are elevated in rheumatoid arthritis, a disease in which it has been suggested to have detrimental effects (Fonesca, J. E. et al., Autoimmunity Reviews, 8:538-42, 2009).", "Because IL-6 signals, at least in part, through JAK1, antagonizing IL-6 directly or indirectly through JAK1 inhibition is expected to provide clinical benefit (Guschin, D., N., et al Embo J 14:1421, 1995; Smolen, J. S., et al.", "Lancet 371:987, 2008).", "Moreover, in some cancers JAK1 is mutated resulting in constitutive undesirable tumor cell growth and survival (Mullighan C G, Proc Natl Acad Sci USA.", "106:9414-8, 2009; Flex E., et al.", "J Exp Med.", "205:751-8, 2008).", "In other autoimmune diseases and cancers elevated systemic levels of inflammatory cytokines that activate JAK1 may also contribute to the disease and/or associated symptoms.", "Therefore, patients with such diseases may benefit from JAK1 inhibition.", "Selective inhibitors of JAK1 may be efficacious while avoiding unnecessary and potentially undesirable effects of inhibiting other JAK kinases.", "Selective inhibitors of JAK1, relative to other JAK kinases, may have multiple therapeutic advantages over less selective inhibitors.", "With respect to selectivity against JAK2, a number of important cytokines and growth factors signal through JAK2 including, for example, erythropoietin (Epo) and thrombopoietin (Tpo) (Parganas E, et al.", "Cell.", "93:385-95, 1998).", "Epo is a key growth factor for red blood cells production; hence a paucity of Epo-dependent signaling can result in reduced numbers of red blood cells and anemia (Kaushansky K, NEJM 354:2034-45, 2006).", "Tpo, another example of a JAK2-dependent growth factor, plays a central role in controlling the proliferation and maturation of megakaryocytes—the cells from which platelets are produced (Kaushansky K, NEJM 354:2034-45, 2006).", "As such, reduced Tpo signaling would decrease megakaryocyte numbers (megakaryocytopenia) and lower circulating platelet counts (thrombocytopenia).", "This can result in undesirable and/or uncontrollable bleeding.", "Reduced inhibition of other JAKs, such as JAK3 and Tyk2, may also be desirable as humans lacking functional version of these kinases have been shown to suffer from numerous maladies such as severe-combined immunodeficiency or hyperimmunoglobulin E syndrome (Minegishi, Y, et al.", "Immunity 25:745-55, 2006; Macchi P, et al.", "Nature.", "377:65-8, 1995).", "Therefore a JAK1 inhibitor with reduced affinity for other JAKs would have significant advantages over a less-selective inhibitor with respect to reduced side effects involving immune suppression, anemia and thrombocytopenia.", "Another aspect of the present invention pertains to methods of treating a JAK-associated disease or disorder in an individual (e.g., patient) by administering to the individual in need of such treatment a therapeutically effective amount or dose of a compound of the present invention or a pharmaceutical composition thereof.", "A JAK-associated disease can include any disease, disorder or condition that is directly or indirectly linked to expression or activity of the JAK, including overexpression and/or abnormal activity levels.", "A JAK-associated disease can also include any disease, disorder or condition that can be prevented, ameliorated, or cured by modulating JAK activity.", "Examples of JAK-associated diseases include diseases involving the immune system including, for example, organ transplant rejection (e.g., allograft rejection and graft versus host disease).", "Further examples of JAK-associated diseases include autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, juvenile arthritis, psoriatic arthritis, type I diabetes, lupus, psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, myasthenia gravis, immunoglobulin nephropathies, myocarditis, autoimmune thyroid disorders, chronic obstructive pulmonary disease (COPD), and the like.", "In some embodiments, the autoimmune disease is an autoimmune bullous skin disorder such as pemphigus vulgaris (PV) or bullous pemphigoid (BP).", "Further examples of JAK-associated diseases include allergic conditions such as asthma, food allergies, eszematous dermatitis, contact dermatitis, atopic dermatitis (atropic eczema), and rhinitis.", "Further examples of JAK-associated diseases include viral diseases such as Epstein Barr Virus (EBV), Hepatitis B, Hepatitis C, HIV, HTLV 1, Varicella-Zoster Virus (VZV) and Human Papilloma Virus (HPV).", "Further examples of JAK-associated disease include diseases associated with cartilage turnover, for example, gouty arthritis, septic or infectious arthritis, reactive arthritis, reflex sympathetic dystrophy, algodystrophy, Tietze syndrome, costal athropathy, osteoarthritis deformans endemica, Mseleni disease, Handigodu disease, degeneration resulting from fibromyalgia, systemic lupus erythematosus, scleroderma, or ankylosing spondylitis.", "Further examples of JAK-associated disease include congenital cartilage malformations, including hereditary chrondrolysis, chrondrodysplasias, and pseudochrondrodysplasias (e.g., microtia, enotia, and metaphyseal chrondrodysplasia).", "Further examples of JAK-associated diseases or conditions include skin disorders such as psoriasis (for example, psoriasis vulgaris), atopic dermatitis, skin rash, skin irritation, skin sensitization (e.g., contact dermatitis or allergic contact dermatitis).", "For example, certain substances including some pharmaceuticals when topically applied can cause skin sensitization.", "In some embodiments, co-administration or sequential administration of at least one JAK inhibitor of the invention together with the agent causing unwanted sensitization can be helpful in treating such unwanted sensitization or dermatitis.", "In some embodiments, the skin disorder is treated by topical administration of at least one JAK inhibitor of the invention.", "In further embodiments, the JAK-associated disease is cancer including those characterized by solid tumors (e.g., prostate cancer, renal cancer, hepatic cancer, pancreatic cancer, gastric cancer, breast cancer, lung cancer, cancers of the head and neck, thyroid cancer, glioblastoma, Kaposi's sarcoma, Castleman's disease, uterine leiomyosarcoma, melanoma etc.", "), hematological cancers (e.g., lymphoma, leukemia such as acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML) or multiple myeloma), and skin cancer such as cutaneous T-cell lymphoma (CTCL) and cutaneous B-cell lymphoma.", "Example CTCLs include Sezary syndrome and mycosis fungoides.", "In some embodiments, the JAK inhibitors described herein, or in combination with other JAK inhibitors, such as those reported in U.S. Ser.", "No.", "11/637,545, which is incorporated herein by reference in its entirety, can be used to treat inflammation-associated cancers.", "In some embodiments, the cancer is associated with inflammatory bowel disease.", "In some embodiments, the inflammatory bowel disease is ulcerative colitis.", "In some embodiments, the inflammatory bowel disease is Crohn's disease.", "In some embodiments, the inflammation-associated cancer is colitis-associated cancer.", "In some embodiments, the inflammation-associated cancer is colon cancer or colorectal cancer.", "In some embodiments, the cancer is gastric cancer, gastrointestinal carcinoid tumor, gastrointestinal stromal tumor (GIST), adenocarcinoma, small intestine cancer, or rectal cancer.", "JAK-associated diseases can further include those characterized by expression of: JAK2 mutants such as those having at least one mutation in the pseudo-kinase domain (e.g., JAK2V617F); JAK2 mutants having at least one mutation outside of the pseudo-kinase domain; JAK1 mutants; JAK3 mutants; erythropoietin receptor (EPOR) mutants; or deregulated expression of CRLF2.JAK-associated diseases can further include myeloproliferative disorders (MPDs) such as polycythemia vera (PV), essential thrombocythemia (ET), myelofibrosis with myeloid metaplasia (MMM), primary myelofibrosis (PMF), chronic myelogenous leukemia (CML), chronic myelomonocytic leukemia (CMML), hypereosinophilic syndrome (HES), systemic mast cell disease (SMCD), and the like.", "In some embodiments, the myeloproliferative disorder is myelofibrosis (e.g., primary myelofibrosis (PMF) or post polycythemia vera/essential thrombocythemia myelofibrosis (Post-PV/ET MF)).", "In some embodiments, the myeloproliferative disorder is post-essential thrombocythemia myelofibrosis (Post-ET MF).", "In some embodiments, the myeloproliferative disorder is post polycythemia vera myelofibrosis (Post-PV MF).", "JAK-associated disease further include myelodysplastic syndrome (MDS).", "The present invention further provides methods of treating psoriasis or other skin disorders by administration of a topical formulation containing a compound of the invention.", "In some embodiments, JAK inhibitors described herein can be used to treat pulmonary arterial hypertension.", "The present invention further provides a method of treating dermatological side effects of other pharmaceuticals by administration of the compound of the invention.", "For example, numerous pharmaceutical agents result in unwanted allergic reactions which can manifest as acneiform rash or related dermatitis.", "Example pharmaceutical agents that have such undesirable side effects include anti-cancer drugs such as gefitinib, cetuximab, erlotinib, and the like.", "The compounds of the invention can be administered systemically or topically (e.g., localized to the vicinity of the dermatitis) in combination with (e.g., simultaneously or sequentially) the pharmaceutical agent having the undesirable dermatological side effect.", "In some embodiments, the compound of the invention can be administered topically together with one or more other pharmaceuticals, where the other pharmaceuticals when topically applied in the absence of a compound of the invention cause contact dermatitis, allergic contact sensitization, or similar skin disorder.", "Accordingly, compositions of the invention include topical formulations containing the compound of the invention and a further pharmaceutical agent which can cause dermatitis, skin disorders, or related side effects.", "Further JAK-associated diseases include inflammation and inflammatory diseases.", "Example inflammatory diseases include sarcoidosis, inflammatory diseases of the eye (e.g., iritis, uveitis, scleritis, conjunctivitis, or related disease), inflammatory diseases of the respiratory tract (e.g., the upper respiratory tract including the nose and sinuses such as rhinitis or sinusitis or the lower respiratory tract including bronchitis, chronic obstructive pulmonary disease, and the like), inflammatory myopathy such as myocarditis, and other inflammatory diseases.", "In some embodiments, the inflammation disease of the eye is blepharitis.", "The JAK inhibitors described herein can further be used to treat ischemia reperfusion injuries or a disease or condition related to an inflammatory ischemic event such as stroke or cardiac arrest.", "The JAK inhibitors described herein can further be used to treat endotoxin-driven disease state (e.g., complications after bypass surgery or chronic endotoxin states contributing to chronic cardiac failure).", "The JAK inhibitors described herein can further be used to treat anorexia, cachexia, or fatigue such as that resulting from or associated with cancer.", "The JAK inhibitors described herein can further be used to treat restenosis, sclerodermitis, or fibrosis.", "The JAK inhibitors described herein can further be used to treat conditions associated with hypoxia or astrogliosis such as, for example, diabetic retinopathy, cancer, or neurodegeneration.", "See, e.g., Dudley, A. C. et al.", "Biochem.", "J 2005, 390(Pt 2):427-36 and Sriram, K. et al.", "J. Biol.", "Chem.", "2004, 279(19):19936-47.Epub 2004 Mar.", "2, both of which are incorporated herein by reference in their entirety.", "The JAK inhibitors described herein can be used to treat Alzheimer's disease.", "The JAK inhibitors described herein can further be used to treat other inflammatory diseases such as systemic inflammatory response syndrome (SIRS) and septic shock.", "The JAK inhibitors described herein can further be used to treat gout and increased prostate size due to, e.g., benign prostatic hypertrophy or benign prostatic hyperplasia.", "Further JAK-associated diseases include bone resorption diseases such as osteoporosis, osteoarthritis.", "Bone resorption can also be associated with other conditions such as hormonal imbalance and/or hormonal therapy, autoimmune disease (e.g.", "osseous sarcoidosis), or cancer (e.g.", "myeloma).", "The reduction of the bone resorption due to the JAK inhibitors can be about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90%.", "In some embodiments, JAK inhibitors described herein can further be used to treat a dry eye disorder.", "As used herein, “dry eye disorder” is intended to encompass the disease states summarized in a recent official report of the Dry Eye Workshop (DEWS), which defined dry eye as “a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface.", "It is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface.” Lemp, “The Definition and Classification of Dry Eye Disease: Report of the Definition and Classification Subcommittee of the International Dry Eye Workshop”, The Ocular Surface, 5(2), 75-92 April 2007, which is incorporated herein by reference in its entirety.", "In some embodiments, the dry eye disorder is selected from aqueous tear-deficient dry eye (ADDE) or evaporative dry eye disorder, or appropriate combinations thereof.", "In some embodiments, the dry eye disorder is Sjogren syndrome dry eye (SSDE).", "In some embodiments, the dry eye disorder is non-Sjogren syndrome dry eye (NSSDE).", "In a further aspect, the present invention provides a method of treating conjunctivitis, uveitis (including chronic uveitis), chorioditis, retinitis, cyclitis, sclieritis, episcleritis, or iritis; treating inflammation or pain related to corneal transplant, LASIK (laser assisted in situ keratomileusis), photorefractive keratectomy, or LASEK (laser assisted sub-epithelial keratomileusis); inhibiting loss of visual acuity related to corneal transplant, LASIK, photorefractive keratectomy, or LASEK; or inhibiting transplant rejection in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the compound of the invention, or a pharmaceutically acceptable salt thereof.", "Additionally, the compounds of the invention, or in combination with other JAK inhibitors, such as those reported in U.S. Ser.", "No.", "11/637,545, which is incorporated herein by reference in its entirety, can be used to treat respiratory dysfunction or failure associated with viral infection, such as influenza and SARS.", "In some embodiments, the present invention provides a compound of Formula I, pharmaceutically acceptable salt thereof, as described in any of the embodiments herein, for use in a method of treating any of the diseases or disorders described herein.", "In some embodiments, the present invention provides the use of a compound of Formula I as described in any of the embodiments herein, for the preparation of a medicament for use in a method of treating any of the diseases or disorders described herein.", "In some embodiments, the present invention provides a compound of Formula I as described herein, or a pharmaceutically acceptable salt thereof, for use in a method of modulating JAK1.In some embodiments, the present invention also provides use of a compound of Formula I as described herein, or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in a method of modulating JAK1.As used herein, the term “contacting” refers to the bringing together of indicated moieties in an in vitro system or an in vivo system.", "For example, “contacting” a JAK with a compound of the invention includes the administration of a compound of the present invention to an individual or patient, such as a human, having a JAK, as well as, for example, introducing a compound of the invention into a sample containing a cellular or purified preparation containing the JAK.", "As used herein, the term “individual” or “patient,” used interchangeably, refers to any animal, including mammals, preferably mice, rats, other rodents, rabbits, dogs, cats, swine, cattle, sheep, horses, or primates, and most preferably humans.", "As used herein, the phrase “therapeutically effective amount” refers to the amount of active compound or pharmaceutical agent that elicits the biological or medicinal response that is being sought in a tissue, system, animal, individual or human by a researcher, veterinarian, medical doctor or other clinician.", "In some embodiments, the therapeutically effective amount is about 5 mg to about 1000 mg, or about 10 mg to about 500 mg. As used herein, the term “treating” or “treatment” refers to one or more of (1) preventing the disease; for example, preventing a disease, condition or disorder in an individual who may be predisposed to the disease, condition or disorder but does not yet experience or display the pathology or symptomatology of the disease; (2) inhibiting the disease; for example, inhibiting a disease, condition or disorder in an individual who is experiencing or displaying the pathology or symptomatology of the disease, condition or disorder (i.e., arresting further development of the pathology and/or symptomatology); and (3) ameliorating the disease; for example, ameliorating a disease, condition or disorder in an individual who is experiencing or displaying the pathology or symptomatology of the disease, condition or disorder (i.e., reversing the pathology and/or symptomatology) such as decreasing the severity of disease.", "Combination Therapies One or more additional pharmaceutical agents such as, for example, chemotherapeutics, anti-inflammatory agents, steroids, immunosuppressants, as well as Bcr-Abl, Flt-3, RAF and FAK kinase inhibitors such as, for example, those described in WO 2006/056399, which is incorporated herein by reference in its entirety, or other agents can be used in combination with the compounds described herein for treatment of JAK-associated diseases, disorders or conditions.", "The one or more additional pharmaceutical agents can be administered to a patient simultaneously or sequentially.", "Example chemotherapeutics include proteosome inhibitors (e.g., bortezomib), thalidomide, revlimid, and DNA-damaging agents such as melphalan, doxorubicin, cyclophosphamide, vincristine, etoposide, carmustine, and the like.", "Example steroids include coriticosteroids such as dexamethasone or prednisone.", "Example Bcr-Abl inhibitors include the compounds, and pharmaceutically acceptable salts thereof, of the genera and species disclosed in U.S. Pat.", "No.", "5,521,184, WO 04/005281, and U.S. Ser.", "No.", "60/578,491, all of which are incorporated herein by reference in their entirety.", "Example suitable Flt-3 inhibitors include compounds, and their pharmaceutically acceptable salts, as disclosed in WO 03/037347, WO 03/099771, and WO 04/046120, all of which are incorporated herein by reference in their entirety.", "Example suitable RAF inhibitors include compounds, and their pharmaceutically acceptable salts, as disclosed in WO 00/09495 and WO 05/028444, both of which are incorporated herein by reference in their entirety.", "Example suitable FAK inhibitors include compounds, and their pharmaceutically acceptable salts, as disclosed in WO 04/080980, WO 04/056786, WO 03/024967, WO 01/064655, WO 00/053595, and WO 01/014402, all of which are incorporated herein by reference in their entirety.", "In some embodiments, one or more of the compounds of the invention can be used in combination with one or more other kinase inhibitors including imatinib, particularly for treating patients resistant to imatinib or other kinase inhibitors.", "In some embodiments, a suitable chemotherapeutical agent can be selected from antimetabolite agents, topoisomerase 1 inhibitors, platinum analogs, taxanes, anthracyclines, and EGFR inhibitors, and combinations thereof.", "In some embodiments, antimetabolite agents include capecitabine, gemcitabine, and fluorouracil (5-FU).", "In some embodiments, taxanes include paclitaxel, Abraxane® (paclitaxel protein-bound particles for injectable suspension), and Taxotere® (docetaxel).", "In some embodiments, platinum analogs include oxaliplatin, cisplatin, and carboplatin.", "In some embodiments, topoisomerase 1 inhibitors include irinotecan and topotecan.", "In some embodiment, anthracyclines include doxorubicin or liposomal formulations of doxorubicin.", "In some embodiments, the chemotherapeutic is FOLFIRINOX (5-FU, lecovorin, irinotecan and oxaliplatin).", "In some embodiments, the chemotherapeutic agent is gemcitabine and Abraxane® (paclitaxel protein-bound particles for injectable suspension).", "In some embodiments, one or more JAK inhibitors of the invention can be used in combination with a chemotherapeutic in the treatment of cancer, such as multiple myeloma, and may improve the treatment response as compared to the response to the chemotherapeutic agent alone, without exacerbation of its toxic effects.", "Examples of additional pharmaceutical agents used in the treatment of multiple myeloma, for example, can include, without limitation, melphalan, melphalan plus prednisone [MP], doxorubicin, dexamethasone, and Velcade (bortezomib).", "Further additional agents used in the treatment of multiple myeloma include Bcr-Abl, Flt-3, RAF and FAK kinase inhibitors.", "Additive or synergistic effects are desirable outcomes of combining a JAK inhibitor of the present invention with an additional agent.", "Furthermore, resistance of multiple myeloma cells to agents such as dexamethasone may be reversible upon treatment with a JAK inhibitor of the present invention.", "The agents can be combined with the present compounds in a single or continuous dosage form, or the agents can be administered simultaneously or sequentially as separate dosage forms.", "In some embodiments, a corticosteroid such as dexamethasone is administered to a patient in combination with at least one JAK inhibitor where the dexamethasone is administered intermittently as opposed to continuously.", "In some further embodiments, combinations of one or more JAK inhibitors of the invention with other therapeutic agents can be administered to a patient prior to, during, and/or after a bone marrow transplant or stem cell transplant.", "In some embodiments, the additional therapeutic agent is fluocinolone acetonide (Retisert®), or rimexolone (AL-2178, Vexol, Alcon).", "In some embodiments, the additional therapeutic agent is cyclosporine (Restasis®).", "In some embodiments, the additional therapeutic agent is a corticosteroid.", "In some embodiments, the corticosteroid is triamcinolone, dexamethasone, fluocinolone, cortisone, prednisolone, or flumetholone.", "In some embodiments, the additional therapeutic agent is selected from Dehydrex™ (Holles Labs), Civamide (Opko), sodium hyaluronate (Vismed, Lantibio/TRB Chemedia), cyclosporine (ST-603, Sirion Therapeutics), ARG101(T) (testosterone, Argentis), AGR1012(P) (Argentis), ecabet sodium (Senju-Ista), gefarnate (Santen), 15-(s)-hydroxyeicosatetraenoic acid (15(S)-HETE), cevilemine, doxycycline (ALTY-0501, Alacrity), minocycline, iDestrin™ (NP50301, Nascent Pharmaceuticals), cyclosporine A (Nova22007, Novagali), oxytetracycline (Duramycin, MOLI1901, Lantibio), CF101 (2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]-N-methyl-oxolane-2-carbamyl, Can-Fite Biopharma), voclosporin (LX212 or LX214, Lux Biosciences), ARG103 (Agentis), RX-10045 (synthetic resolvin analog, Resolvyx), DYN15 (Dyanmis Therapeutics), rivoglitazone (DE011, Daiichi Sanko), TB4 (RegeneRx), OPH-01 (Ophtalmis Monaco), PCS101 (Pericor Science), REV1-31 (Evolutec), Lacritin (Senju), rebamipide (Otsuka-Novartis), OT-551 (Othera), PAI-2 (University of Pennsylvania and Temple University), pilocarpine, tacrolimus, pimecrolimus (AMS981, Novartis), loteprednol etabonate, rituximab, diquafosol tetrasodium (INS365, Inspire), KLS-0611 (Kissei Pharmaceuticals), dehydroepiandrosterone, anakinra, efalizumab, mycophenolate sodium, etanercept (Embrel®), hydroxychloroquine, NGX267 (TorreyPines Therapeutics), actemra, gemcitabine, oxaliplatin, L-asparaginase, or thalidomide.", "In some embodiments, the additional therapeutic agent is an anti-angiogenic agent, cholinergic agonist, TRP-1 receptor modulator, a calcium channel blocker, a mucin secretagogue, MUC1 stimulant, a calcineurin inhibitor, a corticosteroid, a P2Y2 receptor agonist, a muscarinic receptor agonist, an mTOR inhibitor, another JAK inhibitor, Bcr-Abl kinase inhibitor, Flt-3 kinase inhibitor, RAF kinase inhibitor, and FAK kinase inhibitor such as, for example, those described in WO 2006/056399, which is incorporated herein by reference in its entirety.", "In some embodiments, the additional therapeutic agent is a tetracycline derivative (e.g., minocycline or doxycline).", "In some embodiments, the additional therapeutic agent binds to FKBP12.In some embodiments, the additional therapeutic agent is an alkylating agent or DNA cross-linking agent; an anti-metabolite/demethylating agent (e.g., 5-flurouracil, capecitabine or azacitidine); an anti-hormone therapy (e.g., hormone receptor antagonists, SERMs, or aromotase inhibitor); a mitotic inhibitor (e.g.", "vincristine or paclitaxel); an topoisomerase (I or II) inhibitor (e.g.", "mitoxantrone and irinotecan); an apoptotic inducers (e.g.", "ABT-737); a nucleic acid therapy (e.g.", "antisense or RNAi); nuclear receptor ligands (e.g., agonists and/or antagonists: all-trans retinoic acid or bexarotene); epigenetic targeting agents such as histone deacetylase inhibitors (e.g.", "vorinostat), hypomethylating agents (e.g.", "decitabine); regulators of protein stability such as Hsp90 inhibitors, ubiquitin and/or ubiquitin like conjugating or deconjugating molecules; or an EGFR inhibitor (erlotinib).", "In some embodiments, the additional therapeutic agent(s) are demulcent eye drops (also known as “artificial tears”), which include, but are not limited to, compositions containing polyvinylalcohol, hydroxypropyl methylcellulose, glycerin, polyethylene glycol (e.g.", "PEG400), or carboxymethyl cellulose.", "Artificial tears can help in the treatment of dry eye by compensating for reduced moistening and lubricating capacity of the tear film.", "In some embodiments, the additional therapeutic agent is a mucolytic drug, such as N-acetyl-cysteine, which can interact with the mucoproteins and, therefore, to decrease the viscosity of the tear film.", "In some embodiments, the additional therapeutic agent includes an antibiotic, antiviral, antifungal, anesthetic, anti-inflammatory agents including steroidal and non-steroidal anti-inflammatories, and anti-allergic agents.", "Examples of suitable medicaments include aminoglycosides such as amikacin, gentamycin, tobramycin, streptomycin, netilmycin, and kanamycin; fluoroquinolones such as ciprofloxacin, norfloxacin, ofloxacin, trovafloxacin, lomefloxacin, levofloxacin, and enoxacin; naphthyridine; sulfonamides; polymyxin; chloramphenicol; neomycin; paramomycin; colistimethate; bacitracin; vancomycin; tetracyclines; rifampin and its derivatives (“rifampins”); cycloserine; beta-lactams; cephalosporins; amphotericins; fluconazole; flucytosine; natamycin; miconazole; ketoconazole; corticosteroids; diclofenac; flurbiprofen; ketorolac; suprofen; cromolyn; lodoxamide; levocabastin; naphazoline; antazoline; pheniramine; or azalide antibiotic.", "Pharmaceutical Formulations and Dosage Forms When employed as pharmaceuticals, the compounds of the invention can be administered in the form of pharmaceutical compositions.", "These compositions can be prepared in a manner well known in the pharmaceutical art, and can be administered by a variety of routes, depending upon whether local or systemic treatment is desired and upon the area to be treated.", "Administration may be topical (including transdermal, epidermal, ophthalmic and to mucous membranes including intranasal, vaginal and rectal delivery), pulmonary (e.g., by inhalation or insufflation of powders or aerosols, including by nebulizer; intratracheal or intranasal), oral or parenteral.", "Parenteral administration includes intravenous, intraarterial, subcutaneous, intraperitoneal intramuscular or injection or infusion; or intracranial, e.g., intrathecal or intraventricular, administration.", "Parenteral administration can be in the form of a single bolus dose, or may be, for example, by a continuous perfusion pump.", "Pharmaceutical compositions and formulations for topical administration may include transdermal patches, ointments, lotions, creams, gels, drops, suppositories, sprays, liquids and powders.", "Conventional pharmaceutical carriers, aqueous, powder or oily bases, thickeners and the like may be necessary or desirable.", "This invention also includes pharmaceutical compositions which contain, as the active ingredient, the compound of the invention or a pharmaceutically acceptable salt thereof, in combination with one or more pharmaceutically acceptable carriers (excipients).", "In some embodiments, the composition is suitable for topical administration.", "In making the compositions of the invention, the active ingredient is typically mixed with an excipient, diluted by an excipient or enclosed within such a carrier in the form of, for example, a capsule, sachet, paper, or other container.", "When the excipient serves as a diluent, it can be a solid, semi-solid, or liquid material, which acts as a vehicle, carrier or medium for the active ingredient.", "Thus, the compositions can be in the form of tablets, pills, powders, lozenges, sachets, cachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols (as a solid or in a liquid medium), ointments containing, for example, up to 10% by weight of the active compound, soft and hard gelatin capsules, suppositories, sterile injectable solutions, and sterile packaged powders.", "In preparing a formulation, the active compound can be milled to provide the appropriate particle size prior to combining with the other ingredients.", "If the active compound is substantially insoluble, it can be milled to a particle size of less than 200 mesh.", "If the active compound is substantially water soluble, the particle size can be adjusted by milling to provide a substantially uniform distribution in the formulation, e.g.", "about 40 mesh.", "The compounds of the invention may be milled using known milling procedures such as wet milling to obtain a particle size appropriate for tablet formation and for other formulation types.", "Finely divided (nanoparticulate) preparations of the compounds of the invention can be prepared by processes known in the art, e.g., see International App.", "No.", "WO 2002/000196.Some examples of suitable excipients include lactose, dextrose, sucrose, sorbitol, mannitol, starches, gum acacia, calcium phosphate, alginates, tragacanth, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, and methyl cellulose.", "The formulations can additionally include: lubricating agents such as talc, magnesium stearate, and mineral oil; wetting agents; emulsifying and suspending agents; preserving agents such as methyl- and propylhydroxy-benzoates; sweetening agents; and flavoring agents.", "The compositions of the invention can be formulated so as to provide quick, sustained or delayed release of the active ingredient after administration to the patient by employing procedures known in the art.", "In some embodiments, the pharmaceutical composition comprises silicified microcrystalline cellulose (SMCC) and at least one compound described herein, or a pharmaceutically acceptable salt thereof.", "In some embodiments, the silicified microcrystalline cellulose comprises about 98% microcrystalline cellulose and about 2% silicon dioxide w/w.", "In some embodiments, the composition is a sustained release composition comprising at least one compound described herein, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.", "In some embodiments, the composition comprises at least one compound described herein, or a pharmaceutically acceptable salt thereof, and at least one component selected from microcrystalline cellulose, lactose monohydrate, hydroxypropyl methylcellulose, and polyethylene oxide.", "In some embodiments, the composition comprises at least one compound described herein, or a pharmaceutically acceptable salt thereof, and microcrystalline cellulose, lactose monohydrate, and hydroxypropyl methylcellulose.", "In some embodiments, the composition comprises at least one compound described herein, or a pharmaceutically acceptable salt thereof, and microcrystalline cellulose, lactose monohydrate, and polyethylene oxide.", "In some embodiments, the composition further comprises magnesium stearate or silicon dioxide.", "In some embodiments, the microcrystalline cellulose is Avicel PH102™.", "In some embodiments, the lactose monohydrate is Fast-flo 316™.", "In some embodiments, the hydroxypropyl methylcellulose is hydroxypropyl methylcellulose 2208 K4M (e.g., Methocel K4 M Premier™) and/or hydroxypropyl methylcellulose 2208 K100LV (e.g., Methocel K00LV™).", "In some embodiments, the polyethylene oxide is polyethylene oxide WSR 1105 (e.g., Polyox WSR 1105™).", "In some embodiments, a wet granulation process is used to produce the composition.", "In some embodiments, a dry granulation process is used to produce the composition.", "The compositions can be formulated in a unit dosage form, each dosage containing from about 5 to about 1,000 mg (1 g), more usually about 100 mg to about 500 mg, of the active ingredient.", "In some embodiments, each dosage contains about 10 mg of the active ingredient.", "In some embodiments, each dosage contains about 50 mg of the active ingredient.", "In some embodiments, each dosage contains about 25 mg of the active ingredient.", "The term “unit dosage forms” refers to physically discrete units suitable as unitary dosages for human subjects and other mammals, each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic effect, in association with a suitable pharmaceutical excipient.", "In some embodiments, the compositions of the invention contain from about 5 mg to about 50 mg of the active ingredient.", "One having ordinary skill in the art will appreciate that this embodies compounds or compositions containing about 5 mg to about 10 mg, about 10 mg to about 15 mg, about 15 mg to about 20 mg, about 20 mg to about 25 mg, about 25 mg to about 30 mg, about 30 mg to about 35 mg, about 35 mg to about 40 mg, about 40 mg to about 45 mg, or about 45 mg to about 50 mg of the active ingredient.", "In some embodiments, the compositions of the invention contain from about 50 mg to about 500 mg of the active ingredient.", "One having ordinary skill in the art will appreciate that this embodies compounds or compositions containing about 50 mg to about 100 mg, about 100 mg to about 150 mg, about 150 mg to about 200 mg, about 200 mg to about 250 mg, about 250 mg to about 300 mg, about 350 mg to about 400 mg, or about 450 mg to about 500 mg of the active ingredient.", "In some embodiments, the compositions of the invention contain from about 500 mg to about 1,000 mg of the active ingredient.", "One having ordinary skill in the art will appreciate that this embodies compounds or compositions containing about 500 mg to about 550 mg, about 550 mg to about 600 mg, about 600 mg to about 650 mg, about 650 mg to about 700 mg, about 700 mg to about 750 mg, about 750 mg to about 800 mg, about 800 mg to about 850 mg, about 850 mg to about 900 mg, about 900 mg to about 950 mg, or about 950 mg to about 1,000 mg of the active ingredient.", "The active compound may be effective over a wide dosage range and is generally administered in a pharmaceutically effective amount.", "It will be understood, however, that the amount of the compound actually administered will usually be determined by a physician, according to the relevant circumstances, including the condition to be treated, the chosen route of administration, the actual compound administered, the age, weight, and response of the individual patient, the severity of the patient's symptoms, and the like.", "For preparing solid compositions such as tablets, the principal active ingredient is mixed with a pharmaceutical excipient to form a solid preformulation composition containing a homogeneous mixture of a compound of the present invention.", "When referring to these preformulation compositions as homogeneous, the active ingredient is typically dispersed evenly throughout the composition so that the composition can be readily subdivided into equally effective unit dosage forms such as tablets, pills and capsules.", "This solid preformulation is then subdivided into unit dosage forms of the type described above containing from, for example, about 0.1 to about 1000 mg of the active ingredient of the present invention.", "The tablets or pills of the present invention can be coated or otherwise compounded to provide a dosage form affording the advantage of prolonged action.", "For example, the tablet or pill can comprise an inner dosage and an outer dosage component, the latter being in the form of an envelope over the former.", "The two components can be separated by an enteric layer which serves to resist disintegration in the stomach and permit the inner component to pass intact into the duodenum or to be delayed in release.", "A variety of materials can be used for such enteric layers or coatings, such materials including a number of polymeric acids and mixtures of polymeric acids with such materials as shellac, cetyl alcohol, and cellulose acetate.", "The liquid forms in which the compounds and compositions of the present invention can be incorporated for administration orally or by injection include aqueous solutions, suitably flavored syrups, aqueous or oil suspensions, and flavored emulsions with edible oils such as cottonseed oil, sesame oil, coconut oil, or peanut oil, as well as elixirs and similar pharmaceutical vehicles.", "Compositions for inhalation or insufflation include solutions and suspensions in pharmaceutically acceptable, aqueous or organic solvents, or mixtures thereof, and powders.", "The liquid or solid compositions may contain suitable pharmaceutically acceptable excipients as described supra.", "In some embodiments, the compositions are administered by the oral or nasal respiratory route for local or systemic effect.", "Compositions in can be nebulized by use of inert gases.", "Nebulized solutions may be breathed directly from the nebulizing device or the nebulizing device can be attached to a face masks tent, or intermittent positive pressure breathing machine.", "Solution, suspension, or powder compositions can be administered orally or nasally from devices which deliver the formulation in an appropriate manner.", "Topical formulations can contain one or more conventional carriers.", "In some embodiments, ointments can contain water and one or more hydrophobic carriers selected from, for example, liquid paraffin, polyoxyethylene alkyl ether, propylene glycol, white Vaseline, and the like.", "Carrier compositions of creams can be based on water in combination with glycerol and one or more other components, e.g.", "glycerinemonostearate, PEG-glycerinemonostearate and cetylstearyl alcohol.", "Gels can be formulated using isopropyl alcohol and water, suitably in combination with other components such as, for example, glycerol, hydroxyethyl cellulose, and the like.", "In some embodiments, topical formulations contain at least about 0.1, at least about 0.25, at least about 0.5, at least about 1, at least about 2, or at least about 5 wt % of the compound of the invention.", "The topical formulations can be suitably packaged in tubes of, for example, 100 g which are optionally associated with instructions for the treatment of the select indication, e.g., psoriasis or other skin condition.", "The amount of compound or composition administered to a patient will vary depending upon what is being administered, the purpose of the administration, such as prophylaxis or therapy, the state of the patient, the manner of administration, and the like.", "In therapeutic applications, compositions can be administered to a patient already suffering from a disease in an amount sufficient to cure or at least partially arrest the symptoms of the disease and its complications.", "Effective doses will depend on the disease condition being treated as well as by the judgment of the attending clinician depending upon factors such as the severity of the disease, the age, weight and general condition of the patient, and the like.", "The compositions administered to a patient can be in the form of pharmaceutical compositions described above.", "These compositions can be sterilized by conventional sterilization techniques, or may be sterile filtered.", "Aqueous solutions can be packaged for use as is, or lyophilized, the lyophilized preparation being combined with a sterile aqueous carrier prior to administration.", "The pH of the compound preparations typically will be between 3 and 11, more preferably from 5 to 9 and most preferably from 7 to 8.It will be understood that use of certain of the foregoing excipients, carriers, or stabilizers will result in the formation of pharmaceutical salts.", "The therapeutic dosage of a compound of the present invention can vary according to, for example, the particular use for which the treatment is made, the manner of administration of the compound, the health and condition of the patient, and the judgment of the prescribing physician.", "The proportion or concentration of a compound of the invention in a pharmaceutical composition can vary depending upon a number of factors including dosage, chemical characteristics (e.g., hydrophobicity), and the route of administration.", "For example, the compounds of the invention can be provided in an aqueous physiological buffer solution containing about 0.1 to about 10% w/v of the compound for parenteral administration.", "Some typical dose ranges are from about 1 μg/kg to about 1 g/kg of body weight per day.", "In some embodiments, the dose range is from about 0.01 mg/kg to about 100 mg/kg of body weight per day.", "The dosage is likely to depend on such variables as the type and extent of progression of the disease or disorder, the overall health status of the particular patient, the relative biological efficacy of the compound selected, formulation of the excipient, and its route of administration.", "Effective doses can be extrapolated from dose-response curves derived from in vitro or animal model test systems.", "The compositions of the invention can further include one or more additional pharmaceutical agents such as a chemotherapeutic, steroid, anti-inflammatory compound, or immunosuppressant, examples of which are listed hereinabove.", "In some embodiments, the compound, or pharmaceutically acceptable salt thereof, is administered as an ophthalmic composition.", "Accordingly, in some embodiments, the methods comprise administration of the compound, or pharmaceutically acceptable salt thereof, and an ophthalmically acceptable carrier.", "In some embodiments, the ophthalmic composition is a liquid composition, semi-solid composition, insert, film, microparticles or nanoparticles.", "In some embodiments, the ophthalmic composition is a liquid composition.", "In some embodiments, the ophthalmic composition is a semi-solid composition.", "In some embodiments, the ophthalmic composition is a topical composition.", "The topical compositions include, but are not limited to liquid and semi-solid compositions.", "In some embodiments, the ophthalmic composition is a topical composition.", "In some embodiments, the topical composition comprises aqueous solution, an aqueous suspension, an ointment or a gel.", "In some embodiments, the ophthalmic composition is topically applied to the front of the eye, under the upper eyelid, on the lower eyelid and in the cul-de-sac.", "In some embodiments, the ophthalmic composition is sterilized.", "The sterilization can be accomplished by known techniques like sterilizing filtration of the solution or by heating of the solution in the ampoule ready for use.", "The ophthalmic compositions of the invention can further contain pharmaceutical excipients suitable for the preparation of ophthalmic formulations.", "Examples of such excipients are preserving agents, buffering agents, chelating agents, antioxidant agents and salts for regulating the osmotic pressure.", "As used herein, the term “ophthalmically acceptable carrier” refers to any material that can contain and release the compound, or pharmaceutically acceptable salt thereof, and that is compatible with the eye.", "In some embodiments, the ophthalmically acceptable carrier is water or an aqueous solution or suspension, but also includes oils such as those used to make ointments and polymer matrices such as used in ocular inserts.", "In some embodiments, the composition may be an aqueous suspension comprising the compound, or pharmaceutically acceptable salt thereof.", "Liquid ophthalmic compositions, including both ointments and suspensions, may have a viscosity that is suited for the selected route of administration.", "In some embodiments, the ophthalmic composition has a viscosity in the range of from about 1,000 to about 30,000 centipoise.", "In some embodiments, the ophthalmic compositions may further comprise one or more of surfactants, adjuvants, buffers, antioxidants, tonicity adjusters, preservatives (e.g., EDTA, BAK (benzalkonium chloride), sodium chlorite, sodium perborate, polyquaterium-1), thickeners or viscosity modifiers (e.g., carboxymethyl cellulose, hydroxymethyl cellulose, polyvinyl alcohol, polyethylene glycol, glycol 400, propylene glycol hydroxymethyl cellulose, hydroxpropyl-guar, hyaluronic acid, and hydroxypropyl cellulose) and the like.", "Additives in the formulation may include, but are not limited to, sodium chloride, sodium bicarbonate, sorbic acid, methyl paraben, propyl paraben, chlorhexidine, castor oil, and sodium perborate.", "Aqueous ophthalmic compositions (solutions or suspensions) generally do not contain physiologically or ophthalmically harmful constituents.", "In some embodiments, purified or deionized water is used in the composition.", "The pH may be adjusted by adding any physiologically and ophthalmically acceptable pH adjusting acids, bases or buffers to within the range of about 5.0 to 8.5.Ophthalmically acceptable examples of acids include acetic, boric, citric, lactic, phosphoric, hydrochloric, and the like, and examples of bases include sodium hydroxide, sodium phosphate, sodium borate, sodium citrate, sodium acetate, sodium lactate, tromethamine, trishydroxymethylamino-methane, and the like.", "Salts and buffers include citrate/dextrose, sodium bicarbonate, ammonium chloride and mixtures of the aforementioned acids and bases.", "In some embodiments, the methods involve forming or supplying a depot of the therapeutic agent in contact with the external surface of the eye.", "A depot refers to a source of therapeutic agent that is not rapidly removed by tears or other eye clearance mechanisms.", "This allows for continued, sustained high concentrations of therapeutic agent to be present in the fluid on the external surface of the eye by a single application.", "Without wishing to be bound by any theory, it is believed that absorption and penetration may be dependent on both the dissolved drug concentration and the contact duration of the external tissue with the drug containing fluid.", "As the drug is removed by clearance of the ocular fluid and/or absorption into the eye tissue, more drug is provided, e.g.", "dissolved, into the replenished ocular fluid from the depot.", "Accordingly, the use of a depot may more easily facilitate loading of the ocular tissue for more insoluble therapeutic agents.", "In some embodiments, the depot can remain for up to eight hours or more.", "In some embodiments, the ophthalmic depot forms includes, but is not limited to, aqueous polymeric suspensions, ointments, and solid inserts.", "In some embodiments, the ophthalmic composition is an ointment or gel.", "In some embodiment, the ophthalmic composition is an oil-based delivery vehicle.", "In some embodiments, the composition comprises a petroleum or lanolin base to which is added the active ingredient, usually as 0.1 to 2%, and excipients.", "Common bases may include, but are not limited to, mineral oil, petrolatum and combinations thereof.", "In some embodiments, the ointment is applied as a ribbon onto the lower eyelid.", "In some embodiment, the ophthalmic composition is an ophthalmic insert.", "In some embodiments, the ophthalmic insert is biologically inert, soft, bio-erodible, viscoelastic, stable to sterilization after exposure to therapeutic agents, resistant to infections from air borne bacteria, bio-erodible, biocompatible, and/or viscoelastic.", "In some embodiments, the insert comprises an ophthalmically acceptable matrix, e.g., a polymer matrix.", "The matrix is typically a polymer and the therapeutic agent is generally dispersed therein or bonded to the polymer matrix.", "In some embodiments, the therapeutic agent may be slowly released from the matrix through dissolution or hydrolysis of the covalent bond.", "In some embodiments, the polymer is bioerodible (soluble) and the dissolution rate thereof can control the release rate of the therapeutic agent dispersed therein.", "In another form, the polymer matrix is a biodegradable polymer that breaks down such as by hydrolysis to thereby release the therapeutic agent bonded thereto or dispersed therein.", "In further embodiments, the matrix and therapeutic agent can be surrounded with an additional polymeric coating to further control release.", "In some embodiments, the insert comprises a biodegradable polymer such as polycaprolactone (PCL), an ethylene/vinyl acetate copolymer (EVA), polyalkyl cyanoacrylate, polyurethane, a nylon, or poly (dl-lactide-co-glycolide) (PLGA), or a copolymer of any of these.", "In some embodiments, the therapeutic agent is dispersed into the matrix material or dispersed amongst the monomer composition used to make the matrix material prior to polymerization.", "In some embodiments, the amount of therapeutic agent is from about 0.1 to about 50%, or from about 2 to about 20%.", "In further embodiments, the biodegradable or bioerodible polymer matrix is used so that the spent insert does not have to be removed.", "As the biodegradable or bioerodible polymer is degraded or dissolved, the therapeutic agent is released.", "In further embodiments, the ophthalmic insert comprises a polymer, including, but are not limited to, those described in Wagh, et al., “Polymers used in ocular dosage form and drug delivery systems”, Asian J Pharm., pages 12-17 (January 2008), which is incorporated herein by reference in its entirety.", "In some embodiments, the insert comprises a polymer selected from polyvinylpyrrolidone (PVP), an acrylate or methacrylate polymer or copolymer (e.g., Eudragit® family of polymers from Rohm or Degussa), hydroxymethyl cellulose, polyacrylic acid, poly(amidoamine) dendrimers, poly(dimethyl siloxane), polyethylene oxide, poly(lactide-co-glycolide), poly(2-hydroxyethylmethacrylate), poly(vinyl alcohol), or poly(propylene fumarate).", "In some embodiments, the insert comprises Gelfoam® R. In some embodiments, the insert is a polyacrylic acid of 450 kDa-cysteine conjugate.", "In some embodiments, the ophthalmic composition is a ophthalmic film.", "Polymers suitable for such films include, but are not limited to, those described in Wagh, et al.", "(ibid), In some embodiments, the film is a soft-contact lens, such as ones made from copolymers of N,N-diethylacrylamide and methacrylic acid crosslinked with ethyleneglycol dimethacrylate.", "In some embodiments, the ophthalmic composition comprises microspheres or nanoparticles.", "In some embodiment, the microspheres comprise gelatin.", "In some embodiments, the microspheres are injected to the posterior segment of the eye, in the chroroidal space, in the sclera, intravitreally or sub-retinally.", "In some embodiments, the microspheres or nanoparticles comprises a polymer including, but not limited to, those described in Wagh, et al.", "(ibid), which is incorporated herein by reference in its entirety.", "In some embodiments, the polymer is chitosan, a polycarboxylic acid such as polyacrylic acid, albumin particles, hyaluronic acid esters, polyitaconic acid, poly(butyl)cyanoacrylate, polycaprolactone, poly(isobutyl)caprolactone, poly(lactic acid-co-glycolic acid), or poly(lactic acid).", "In some embodiments, the microspheres or nanoparticles comprise solid lipid particles.", "In some embodiments, the ophthalmic composition comprises an ion-exchange resin.", "In some embodiments, the ion-exchange resin is an inorganic zeolite or synthetic organic resin.", "In some embodiments, the ion-exchange resin includes, but is not limited to, those described in Wagh, et al.", "(ibid), which is incorporated herein by reference in its entirety.", "In some embodiments, the ion-exchange resin is a partially neutralized polyacrylic acid.", "In some embodiments, the ophthalmic composition is an aqueous polymeric suspension.", "In some embodiments, the therapeutic agent or a polymeric suspending agent is suspended in an aqueous medium.", "In some embodiments, the aqueous polymeric suspensions may be formulated so that they retain the same or substantially the same viscosity in the eye that they had prior to administration to the eye.", "In some embodiments, they may be formulated so that there is increased gelation upon contact with tear fluid.", "Labeled Compounds and Assay Methods Another aspect of the present invention relates to labeled compounds of the invention (radio-labeled, fluorescent-labeled, etc.)", "that would be useful not only in imaging techniques but also in assays, both in vitro and in vivo, for localizing and quantitating JAK in tissue samples, including human, and for identifying JAK ligands by inhibition binding of a labeled compound.", "Accordingly, the present invention includes JAK assays that contain such labeled compounds.", "The present invention further includes isotopically-labeled compounds of the invention.", "An “isotopically” or “radio-labeled” compound is a compound of the invention where one or more atoms are replaced or substituted by an atom having an atomic mass or mass number different from the atomic mass or mass number typically found in nature (i.e., naturally occurring).", "Suitable radionuclides that may be incorporated in compounds of the present invention include but are not limited to 3H (also written as T for tritium), 11C, 13C, 14C, 13N, 15N, 15O, 17O, 18O, 18F, 35S, 36Cl, 82Br, 75Br, 76Br, 77Br, 123I, 124I, 125I and 131I.", "The radionuclide that is incorporated in the instant radio-labeled compounds will depend on the specific application of that radio-labeled compound.", "For example, for in vitro JAK labeling and competition assays, compounds that incorporate 3H, 14C, 82Br, 125I, 131I, 35S or will generally be most useful.", "For radio-imaging applications 11C, 18F, 125I, 123I, 124I, 131I, 75Br, 76Br or 77Br will generally be most useful.", "It is to be understood that a “radio-labeled” or “labeled compound” is a compound that has incorporated at least one radionuclide.", "In some embodiments the radionuclide is selected from the group consisting of 3H, 14C, 125I, 35S and 82Br.", "In some embodiments, the compound incorporates 1, 2, or 3 deuterium atoms.", "The present invention can further include synthetic methods for incorporating radio-isotopes into compounds of the invention.", "Synthetic methods for incorporating radio-isotopes into organic compounds are well known in the art, and an ordinary skill in the art will readily recognize the methods applicable for the compounds of invention.", "A labeled compound of the invention can be used in a screening assay to identify/evaluate compounds.", "For example, a newly synthesized or identified compound (i.e., test compound) which is labeled can be evaluated for its ability to bind a JAK by monitoring its concentration variation when contacting with the JAK, through tracking of the labeling.", "For example, a test compound (labeled) can be evaluated for its ability to reduce binding of another compound which is known to bind to a JAK (i.e., standard compound).", "Accordingly, the ability of a test compound to compete with the standard compound for binding to the JAK directly correlates to its binding affinity.", "Conversely, in some other screening assays, the standard compound is labeled and test compounds are unlabeled.", "Accordingly, the concentration of the labeled standard compound is monitored in order to evaluate the competition between the standard compound and the test compound, and the relative binding affinity of the test compound is thus ascertained.", "Kits The present invention also includes pharmaceutical kits useful, for example, in the treatment or prevention of JAK-associated diseases or disorders, such as cancer, which include one or more containers containing a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention.", "Such kits can further include, if desired, one or more of various conventional pharmaceutical kit components, such as, for example, containers with one or more pharmaceutically acceptable carriers, additional containers, etc., as will be readily apparent to those skilled in the art.", "Instructions, either as inserts or as labels, indicating quantities of the components to be administered, guidelines for administration, and/or guidelines for mixing the components, can also be included in the kit.", "The invention will be described in greater detail by way of specific examples.", "The following examples are offered for illustrative purposes, and are not intended to limit the invention in any manner.", "Those of skill in the art will readily recognize a variety of non-critical parameters which can be changed or modified to yield essentially the same results.", "The compounds of the Examples have been found to be JAK inhibitors according to at least one assay described herein.", "EXAMPLES Example 1.", "(1R)-1-{1-[(3S)-Tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol Step 1.6-Nitrothieno[3,2-b]pyridin-7-ol N,N,N-Tributylbutan-1-aminium nitrate (from Aldrich, 9.1 g, 30 mmol) dissolved in methylene chloride (100 mL) was added dropwise to a stirred solution of thieno[3,2-b]pyridin-7-ol (from Aldrich, 3.0 g, 20 mmol) in methylene chloride (100 mL) at −5° C. Trifluoroacetic anhydride (4.5 mL, 32 mmol) was added while maintaining the temperature below 0° C. The resulting mixture was then stirred at −5° C. for 30 min and at room temperature overnight.", "The reaction mixture was concentrated, diluted with ether, filtered.", "The solid collected was washed with water and then ether/methanol (MeOH) mixture (1:1), and air-dried to give the desired product (3.3 g, 85%).", "LCMS calculated for C7H5N2O3S (M+H)+: m/z=197.0; Found: 196.9.Step 2.7-Chloro-6-nitrothieno[3,2-b]pyridine 6-Nitrothieno[3,2-b]pyridin-7-ol (3.3 g, 17 mmol) was suspended in phosphoryl chloride (30 mL, 400 mmol) and heated at reflux for 1 h (dissolution was apparent after 45 min).", "The solvent was removed.", "Toluene was added to the residue and the volatiles were removed in vacuo.", "Dichloromethane and sat.", "NaHCO3 solution were added (Caution: gas evolution), and the layers separated.", "The organic layer was washed with water, dried over MgSO4 and concentrated to give the desired product (2.7 g, 75%).", "LCMS calculated for C7H4ClN2O2S (M+H)+: m/z=215.0; Found: 214.9.Step 3.6-Nitro-N-[(3S)-tetrahydro-2H-pyran-3-yl]thieno[3,2-b]pyridin-7-amine A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.060 g, 0.28 mmol), (3S)-tetrahydro-2H-pyran-3-amine hydrochloride (from J&W Pharmatech, 0.059 g, 0.43 mmol) and N,N-diisopropylethylamine (0.15 mL, 0.84 mmol) in isopropyl alcohol (0.95 mL) was heated at 60° C. overnight.", "The resulting mixture was concentrated and purified on silica gel (eluting with 0 to 50% ethyl acetate (EtOAc) in hexanes) to give the desired product (30 mg, 38%).", "LCMS calculated for C12H14N3O3S (M+H)+: m/z=280.1; Found: 280.0.Step 4.N7-[(3S)-Tetrahydro-2H-pyran-3-yl]thieno[3,2-b]pyridine-6,7-diamine A mixture of 6-nitro-N-[(3S)-tetrahydro-2H-pyran-3-yl]thieno[3,2-b]pyridin-7-amine (30 mg, 0.1 mmol), iron (18 mg, 0.32 mmol) and ammonium chloride (29 mg, 0.54 mmol) in ethanol (0.8 mL)/water (0.3 mL) was heated at reflux for 4 h. The resulting mixture was filtered.", "The filtrate was diluted with EtOAc, washed with sat.", "NaHCO3 solution, dried over MgSO4, and concentrated.", "The residue was purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product.", "LCMS calculated for C12H16N3OS (M+H)+: m/z=250.1; Found: 250.0.Step 5.", "(1R)-1-{f-[(3S)-Tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol A mixture of (2R)-2-hydroxypropanamide (from Aldrich, 5.4 mg, 0.060 mmol) and triethyloxonium tetrafluoroborate (12 mg, 0.062 mmol) in tetrahydrofuran (0.1 mL) became a solution after stirred for 15 min.", "After another 45 min, this solution was added to a mixture of N7-[(3S)-tetrahydro-2H-pyran-3-yl]thieno[3,2-b]pyridine-6,7-diamine (7.5 mg, 0.030 mmol) in ethanol (0.24 mL) and the resultant mixture was heated at reflux for 2 h. The crude mixture was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (5.9 mg, 65%).", "LCMS calculated for C15H8N3O2S (M+H)+: m/z=304.1; Found: 304.0.Example 2.", "(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile Step 1.", "{trans-4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methanol A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.21 g, 0.98 mmol) (Example 1, Step 2), (trans-4-aminocyclohexyl)methanol (from J&W Pharmatech, 0.25 g, 2.0 mmol) and N,N-diisopropylethylamine (0.51 mL, 2.9 mmol) in isopropyl alcohol (3.3 mL) was heated at 90° C. for 2 h. The resulting mixture was concentrated and purified on silica gel (eluting with 0 to 60% EtOAc in hexanes) to give the desired product (0.26 g, 86%).", "LCMS calculated for C14H18N3O3S (M+H)+: m/z=308.1; Found: 308.0.Step 2.", "{trans-4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methyl methanesulfonate To a mixture of {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methanol (0.26 g, 0.84 mmol) and N,N-diisopropylethylamine (0.30 mL, 1.7 mmol) in methylene chloride (3 mL) was added methanesulfonyl chloride (0.085 mL, 1.1 mmol).", "The resulting mixture was stirred at room temperature for 2 h. After diluting with water, the mixture was extracted with dichloromethane.", "The organic layers were concentrated and purified on silica gel (eluting with 0 to 70% EtOAc in hexanes) to give the desired product (0.2 g, 61%).", "LCMS calculated for C15H20N3O5S2(M+H)+: m/z=386.1; Found: 386.0.Step 3.", "{trans-4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile A mixture of {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methyl methanesulfonate (0.20 g, 0.52 mmol) and sodium cyanide (0.057 g, 1.2 mmol) in dimethyl sulfoxide (2 mL) was stirred at 90° C. for 4 h. After diluting with EtOAc, the resulting mixture was washed with sat.", "NaHCO3 solution, water and brine, then concentrated.", "The residue was purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product.", "LCMS calculated for C15H17N4O2S (M+H)+: m/z=317.1; Found: 317.0.Step 4.", "{trans-4-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile A mixture of {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (0.16 g, 0.50 mmol) and 10% palladium on carbon (20 mg) in methanol (5 mL) was hydrogenated under balloon pressure of H2 at room temperature for 2 h. The reaction mixture was filtered and the filtrate concentrated to give the desired product (0.124 g, 86%), which was used directly in the next step.", "LCMS calculated for C15H19N4S (M+H)+: m/z=287.1; Found: 287.1.Step 5.", "(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile A mixture of (2R)-2-hydroxypropanamide (0.12 g, 1.3 mmol) and triethyloxonium tetrafluoroborate (0.25 g, 1.3 mmol) in tetrahydrofuran (2 mL) became a solution after stirred for 15 min.", "After another 45 min, this solution was added to a mixture of {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (124 mg, 0.433 mmol) in ethanol (3.4 mL) and the resultant mixture was heated at reflux for 2 h. The crude mixture was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (65 mg, 44%).", "LCMS calculated for C18H21N4OS (M+H)+: m/z=341.1; Found: 341.1.1H NMR (DMSO-d6, 400 MHz) δ 8.98 (1H, s), 8.00 (1H, d, J=5.2 Hz), 7.66 (1H, d, J=5.2 Hz), 5.86 (1H, d, J=6.4 Hz), 5.19 (1H, m), 4.92 (1H, m), 2.61 (2H, d, J=6.0 Hz), 2.43 (2H, m), 2.01 (5H, m), 1.64 (3H, d, J=6.4 Hz), 1.40 (2H, m) ppm.", "Example 3.trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexanol Step 1.trans-4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanol A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.47 g, 2.2 mmol) (Example 1, step 2), trans-4-aminocyclohexanol (from Aldrich, 0.50 g, 4.4 mmol) and N,N-diisopropylethylamine (1.1 mL, 6.6 mmol) in isopropyl alcohol (7.4 mL) was heated at 90° C. for 2 h. The reaction mixture was concentrated and purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product (0.266 g, 41%).", "LCMS calculated for C13H16N3O3S (M+H)+: m/z=294.1; Found: 294.0.Step 2.trans-4-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexanol A mixture of trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanol (50 mg, 0.2 mmol) and 10% palladium on carbon (7 mg) in methanol (2 mL) was hydrogenated under balloon pressure of H2 at room temperature for 2 h. The reaction mixture was filtered.", "The filtrate was concentrated to give the desired product, which was used directly in the next step.", "LCMS calculated for C13H18N3OS (M+H)+: m/z=264.1; Found: 264.1.Step 3.trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexanol A mixture of (2R)-2-hydroxypropanamide (96 mg, 1.1 mmol) and triethyloxonium tetrafluoroborate (0.20 g, 1.1 mmol) in tetrahydrofuran (2 mL) became a solution after stirred for 15 min.", "After another 45 min, this solution was added to a mixture of trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexanol (95 mg, 0.36 mmol) in ethanol (2.9 mL) and heated at reflux for 2 h. The resulting mixture was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (0.9 mg, 0.8%).", "LCMS calculated for C16H20N3O2S (M+H)+: m/z=318.1; Found: 318.0.Example 4.", "(1R)-1-(1-{trans-4-[(2,2,2-Trifluoroethyl)amino]cyclohexyl}-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol Step 1.trans-N-(6-Nitrothieno[3,2-b]pyridin-7-yl)cyclohexane-1,4-diamine A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.21 g, 0.98 mmol) (Example 1, step 2), trans-cyclohexane-1,4-diamine (from Aldrich, 0.13 g, 1.2 mmol) and N,N-diisopropylethylamine (0.34 mL, 2.0 mmol) in isopropyl alcohol (3.3 mL) was heated at 90° C. for 2 h. The solvent in the resulting mixture was removed to give the desired product, which was used directly in the next step.", "LCMS calculated for C13H17N4O2S (M+H)+: m/z=293.1; Found: 293.0.Step 2.trans-N-(6-Nitrothieno[3,2-b]pyridin-7-yl)-N′-(2,2,2-trifluoroethyl)cyclohexane-1,4-diamine To a mixture of trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)cyclohexane-1,4-diamine (120 mg, 0.41 mmol) and N,N-diisopropylethylamine (0.36 mL, 2.0 mmol) in methylene chloride (2 mL)/N,N-dimethylformamide (2 mL) was added 2,2,2-trifluoroethyl trifluoromethanesulfonate (0.18 mL, 1.2 mmol).", "The reaction was stirred at room temperature for 4 h. The resulting mixture was diluted with water, extracted with dichloromethane.", "The organic layers were concentrated and purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product (34 mg, 22%).", "LCMS calculated for C15H8F3N4O2S (M+H)+: m/z=375.1; Found: 375.0.Step 3.N7-{trans-4-[(2,2,2-Trifluoroethyl)amino]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine A mixture of trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)-N′-(2,2,2-trifluoroethyl)cyclohexane-1,4-diamine (34 mg, 0.091 mmol) and 10% palladium on carbon (4 mg) in methanol (0.9 mL) was hydrogenated under balloon pressure of H2 at room temperature for 2 h. The reaction mixture was filtered and the filtrate was concentrated to give the desired product (27 mg, 86%), which was used directly in the next step.", "LCMS calculated for C15H20F3N4S (M+H)+: m/z=345.1; Found: 345.0.Step 4.", "(1R)-1-(1-{trans-4-[(2,2,2-Trifluoroethyl)amino]cyclohexyl}-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol A mixture of (2R)-2-hydroxypropanamide (21 mg, 0.24 mmol) and triethyloxonium tetrafluoroborate (45 mg, 0.24 mmol) in tetrahydrofuran (0.3 mL) became a solution after stirring for 15 min.", "After another 45 min, this solution was added to a mixture of N7-{trans-4-[(2,2,2-trifluoroethyl)amino]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine (27 mg, 0.078 mmol) in ethanol (0.62 mL) and heated at reflux for 2 h. The resulting mixture was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (3.2 mg, 10%).", "LCMS calculated for C18H22F3N4OS (M+H)+: m/z=399.1; Found: 399.2.Example 5.", "(1R)-1-(1-{trans-4-[2-(Methylsulfonyl)ethyl]cyclohexyl}-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol Step 1.tert-Butyl (trans-4-formylcyclohexyl)carbamate A solution of tert-butyl [trans-4-(hydroxymethyl)cyclohexyl]carbamate (from Aldrich, 0.61 g, 2.7 mmol) in methylene chloride (10 mL) at 0° C. was added Dess-Martin periodinane (1.35 g, 3.19 mmol).", "The resulting mixture was stirred at room temperature overnight.", "The reaction was quenched with aq.", "1 N NaOH solution, extracted with dichloromethane.", "The combined organic layers were washed with water and brine, dried over MgSO4, and concentrated.", "The residue was purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product (0.3 g, 50%).", "LCMS calculated for C12H21NO3Na (M+Na)+: m/z=250.2; Found: 250.1.Step 2.tert-Butyl {trans-4-[2-(methylsulfonyl)vinyl]cyclohexyl}carbamate To a solution of 1.0 M potassium tert-butoxide in tetrahydrofuran (THF) (1.0 mL, 1.0 mmol) was added diethyl [(methylsulfonyl)methyl]phosphonate (0.21 g, 0.92 mmol) dropwise at 0° C. and the resulting mixture was stirred at 0° C. for 1 h. A solution of tert-butyl (trans-4-formylcyclohexyl)carbamate (0.15 g, 0.66 mmol) in tetrahydrofuran (4.6 mL) was added dropwise, then cooling bath was removed and the mixture was stirred at room temperature for 1 h. The reaction mixture was diluted with EtOAc, washed with water, concentrated and purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product (0.14 g, 70%) as a mixture of E- and Z-isomers.", "LCMS calculated for C14H25NO4SNa (M+Na)+: m/z=326.2; Found: 326.1.Step 3.trans-4-(2-(Methylsulfonyl)ethyl)cyclohexanamine trifluoroacetate A mixture of tert-butyl {trans-4-[2-(methylsulfonyl)vinyl]cyclohexyl}carbamate (140 mg, 0.46 mmol) and 10% of palladium on carbon (49 mg) in methanol (4 mL) was hydrogenated under balloon pressure of H2 at room temperature overnight.", "The reaction mixture was filtered and the filtrate was concentrated to give tert-butyl {trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}carbamate.", "LCMS calculated for C9H20NO2S (M-Boc+2H)+: m/z=206.1; Found: 206.1.The Boc-intermediate was treated with trifluoroacetic acid (0.2 mL, 3 mmol) in methylene chloride (0.5 mL) at room temperature for 1 h. The resulting mixture was concentrated to give the desired product as trifluoroacetic acid (TFA) salt.", "LCMS calculated for C9H20NO2S (M+H)+: m/z=206.1; Found: 206.1.Step 4.N-{trans-4-[2-(Methylsulfonyl)ethyl]cyclohexyl}-6-nitrothieno[3,2-b]pyridin-7-amine A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.10 g, 0.46 mmol), trans-4-[2-(methylsulfonyl)ethyl]cyclohexanamine TFA salt (0.12 g, 0.60 mmol) and N,N-diisopropylethylamine (0.40 mL, 2.3 mmol) in isopropyl alcohol (1.0 mL) was heated at 90° C. for 2 h. The reaction mixture was concentrated and purified on silica gel (eluting with 0 to 45% EtOAc in dichloromethane) to give the desired product.", "LCMS calculated for C16H22N3O4S2 (M+H)+: m/z=384.1; Found: 384.0.Step 5.N7-{trans-4-[2-(Methylsulfonyl)ethyl]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine A mixture of N-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}-6-nitrothieno[3,2-b]pyridin-7-amine (220 mg, 0.57 mmol) and 10% palladium on carbon (60 mg, 0.06 mmol) in methanol (4 mL) was hydrogenated under balloon pressure of H2 at room temperature for 2 h. The reaction mixture was filtered and the filtrate was concentrated to give the desired product, which was used in the next step directly.", "LCMS calculated for C16H24N3O2S2 (M+H)+: m/z=354.1; Found: 354.0.Step 6.", "(1R)-1-(1-{trans-4-[2-(Methylsulfonyl)ethyl]cyclohexyl}-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol A mixture of (2R)-2-hydroxypropanamide (52 mg, 0.59 mmol) and triethyloxonium tetrafluoroborate (0.11 g, 0.59 mmol) in tetrahydrofuran (1 mL) became a solution after stirring for 15 min.", "After another 45 min, this solution was added to a mixture of N7-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine (83 mg, 0.23 mmol) in ethanol (2 mL) and heated at reflux overnight.", "The resulting mixture was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (1.1 mg, 1.1%).", "LCMS calculated for C19H26N3O3S2 (M+H)+: m/z=408.1; Found: 408.1.Example 6.", "(1R)-1-{1-[cis-4-(1H-1,2,4-Triazol-1-yl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol Step 1.trans-4-[(tert-Butoxycarbonyl)amino]cyclohexyl methanesulfonate To a mixture of tert-butyl (trans-4-hydroxycyclohexyl)carbamate (from AstaTech, 0.133 g, 0.618 mmol) and triethylamine (0.12 mL, 0.86 mmol) in methylene chloride (1 mL) was added methanesulfonyl chloride (0.057 mL, 0.74 mmol).", "The reaction mixture was stirred at room temperature for 2 h. After dilution with sat.", "aq.", "NaHCO3 solution, the mixture was extracted with dichloromethane.", "The combined organic layers were washed with brine, dried over MgSO4 and concentrated to give the desired product (0.18 g, 99%).", "Step 2.cis-4-(1H-1,2,4-Triazol-1-yl)cyclohexanamine trifluoroacetate Sodium hydride (60%, 0.034 g, 0.86 mmol) was added portionwise to a solution of 1H-1,2,4-triazole (0.064 g, 0.92 mmol) in N,N-dimethylformamide (2 mL).", "After stirred for 5 min, trans-4-[(tert-butoxycarbonyl)amino]cyclohexyl methanesulfonate (0.18 g, 0.61 mmol) was added.", "The resulting mixture was stirred at 65° C. over weekend.", "The cooled mixture was poured into ice-cold water, extracted with EtOAc.", "The organic layers were concentrated and purified on silica gel (eluting with 0 to 5% MeOH in EtOAc) to give tert-butyl [cis-4-(1H-1,2,4-triazol-1-yl)cyclohexyl]carbamate (0.14 g, 86%).", "LCMS calculated for C13H23N4O2 (M+H)+: m/z=267.2; Found: 267.1.This carbamate intermediate was treated with trifluoroacetic acid (0.28 mL, 3.7 mmol) in methylene chloride (1 mL) at room temperature for 1 h and then concentrated to give the desired product as TFA salt.", "LCMS calculated for C8H15N4 (M+H)+: m/z=167.1; Found: 167.2.Step 3.6-Nitro-N-[cis-4-(1H-1,2,4-triazol-1-yl)cyclohexyl]thieno[3,2-b]pyridin-7-amine A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.10 g, 0.46 mmol), cis-4-(1H-1,2,4-triazol-1-yl)cyclohexanamine TFA salt (0.10 g, 0.60 mmol) and N,N-diisopropylethylamine (0.40 mL, 2.3 mmol) in isopropyl alcohol (1.0 mL) was heated at 90° C. for 2 h. The resulting mixture was concentrated and purified on silica gel (eluting with 0 to 10% EtOAc in dichloromethane) to give the desired product (32 mg, 20%).", "LCMS calculated for C15H17N6O2S (M+H)+: m/z=345.1; Found: 345.0.Step 4.N7-[cis-4-(1H-1,2,4-Triazol-1-yl)cyclohexyl]thieno[3,2-b]pyridine-6,7-diamine A mixture of 6-nitro-N-[cis-4-(1H-1,2,4-triazol-1-yl)cyclohexyl]thieno[3,2-b]pyridin-7-amine (32 mg, 0.093 mmol) and 10% palladium on carbon (4 mg) in methanol (0.9 mL) was hydrogenated under balloon pressure of H2 at room temperature for 2 h. The reaction was filtered and the resultant filtrate was concentrated to give the desired product, which was used directly in the next step.", "LCMS calculated for C15H19N6S (M+H)+: m/z=315.1; Found: 315.1.Step 5.", "(1R)-1-{1-[cis-4-(1H-1,2,4-Triazol-1-yl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol A mixture of (2R)-2-hydroxypropanamide (28 mg, 0.32 mmol) and triethyloxonium tetrafluoroborate (60 mg, 0.32 mmol) in tetrahydrofuran (0.4 mL) became a solution after stirring for 15 min.", "After another 45 min, this solution was added to a mixture of N7-[cis-4-(1H-1,2,4-triazol-1-yl)cyclohexyl]thieno[3,2-b]pyridine-6,7-diamine (25 mg, 0.080 mmol) in ethanol (0.8 mL) and heated at reflux overnight.", "The resulting mixture was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (1.7 mg, 5.8%).", "LCMS calculated for C18H21N6OS (M+H)+: m/z=369.1; Found: 369.1.Example 7.cis-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexanecarbonitrile Step 1.trans-4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl methanesulfonate To a mixture of trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanol (0.21 g, 0.72 mmol) (Example 3, Step 1) and N,N-diisopropylethylamine (0.25 mL, 1.4 mmol) in methylene chloride (2 mL) was added methanesulfonyl chloride (0.083 mL, 1.1 mmol).", "The reaction was stirred at room temperature for 2 h. After dilution with sat.", "aq.", "NaHCO3 solution, the resulting mixture was extracted with dichloromethane.", "The organic layers were concentrated and purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product (0.24 g, 90%).", "LCMS calculated for C14H18N3O5S2 (M+H)+: m/z=372.1; Found: 372.0.Step 2.cis-4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile A mixture of trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl methanesulfonate (0.12 g, 0.32 mmol) and sodium cyanide (0.061 g, 1.2 mmol) in dimethyl sulfoxide (1 mL) was stirred at 90° C. for 6 h. After dilution with EtOAc, the resulting mixture was washed with sat.", "NaHCO3 solution, water and brine, and then concentrated.", "The residue was purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product (32 mg).", "LCMS calculated for C14H15N4O2S (M+H)+: m/z=303.1; Found: 303.0.Step 3.cis-4-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile A mixture of cis-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile (32 mg, 0.10 mmol) and 10% palladium on carbon (4 mg) in methanol (1 mL) was hydrogenated under balloon pressure of H2 at room temperature for 4 h. The mixture was filtered and the filtrate was concentrated to give the desired product, which was used directly in the next step.", "LCMS calculated for C14H17N4S (M+H)+: m/z=273.1; Found: 273.1.Step 4.cis-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexanecarbonitrile A mixture of (2R)-2-hydroxypropanamide (40 mg, 0.4 mmol) and triethyloxonium tetrafluoroborate (89 mg, 0.47 mmol) in tetrahydrofuran (0.4 mL) became a solution after stirring for 15 min.", "After another 45 min, this solution was added to a mixture of cis-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile (32 mg, 0.12 mmol) in ethanol (0.74 mL) and heated at reflux overnight.", "The resulting mixture was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (1.1 mg, 2.9%).", "LCMS calculated for C17H19N4OS (M+H)+: m/z=327.1; Found: 327.0.Example 8.3-(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)propanenitrile Step 1.tert-Butyl {trans-4-[2-cyanovinyl]cyclohexyl}carbamate To a solution of 1.0 M potassium tert-butoxide in THF (1.0 mL, 1.0 mmol) was added diethyl cyanomethylphosphonate (0.15 mL, 0.92 mmol) dropwise at 0° C. and the resulting mixture was stirred at 0° C. for 1 h. A solution of tert-butyl (trans-4-formylcyclohexyl)carbamate (0.15 g, 0.66 mmol) (Example 5, Step 1) in tetrahydrofuran (4.6 mL) was added dropwise, then cooling bath was removed and the reaction mixture was stirred at room temperature for 1 h. The reaction was diluted with EtOAc, washed with water.", "The organic layers were concentrated and purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product as a mixture of E- and Z-isomers (0.14 g, 70%).", "LCMS calculated for C14H22N2O2Na (M+Na)+: m/z=273.2; Found: 273.0.Step 2.3-(trans-4-Aminocyclohexyl)propanenitrile trifluoroacetate A mixture of tert-butyl {trans-4-[2-cyanovinyl]cyclohexyl}carbamate (0.13 g, 0.52 mmol) and 10% palladium on carbon (52 mg) in ethanol (2 mL) was hydrogenated under balloon pressure of H2 over weekend.", "The mixture was filtered, and the filtrate was concentrated to give tert-butyl [trans-4-(2-cyanoethyl)cyclohexyl]carbamate.", "LCMS calculated for C10H17N2O2 (M-tBu+H)+: m/z=197.1; Found: 197.1.This carbamate intermediate was treated with trifluoroacetic acid (0.4 mL, 5 mmol) in methylene chloride (1 mL) at room temperature for 1 h, and then the solvent removed to give the desired product as TFA salt.", "LCMS calculated for C9H17N2 (M+H)+: m/z=153.1; Found: 153.2.Step 3.3-{trans-4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}propanenitrile A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.087 g, 0.41 mmol), 3-(trans-4-aminocyclohexyl)propanenitrile (0.080 g, 0.52 mmol) TFA salt and N,N-diisopropylethylamine (0.35 mL, 2.0 mmol) in isopropyl alcohol (0.89 mL) was heated at 90° C. for 2 h. The resulting mixture was concentrated and purified on silica gel (eluting with 0 to 20% EtOAc in dichloromethane) to give the desired product (63 mg, 47%).", "LCMS calculated for C16H19N4O2S (M+H)+: m/z=331.1; Found: 331.0.Step 4.3-{trans-4-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}propanenitrile A mixture of 3-{trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}propanenitrile (63 mg, 0.19 mmol) and 10% palladium on carbon (20 mg) in methanol (1 mL) was hydrogenated under balloon pressure of H2 at room temperature for 2 h. The reaction mixture was filtered and the filtrate was concentrated to give the desired product (48 mg, 84%), which was used directly in the next step.", "LCMS calculated for C16H21N4S (M+H)+: m/z=301.1; Found: 301.1.Step 5.3-(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)propanenitrile To a mixture of 3-{trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}propanenitrile (0.048 g, 0.16 mmol) and (R)-2-hydroxypropanoic acid (0.019 g, 0.21 mmol) in methylene chloride (0.96 mL) was added N,N-diisopropylethylamine (60 μL, 0.35 mmol) and N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (66 mg, 0.17 mmol).", "The resulting mixture was stirred at room temperature overnight.", "The mixture was washed with water.", "The organic layers were concentrated and purified on silica gel (eluting with 0 to 10% MeOH in dichloromethane) to give (2R)—N-(7-{[trans-4-(2-cyanoethyl)cyclohexyl]amino}thieno[3,2-b]pyridin-6-yl)-2-hydroxypropanamide.", "LCMS calculated for C19H25N4O2S (M+H)+: m/z=373.2; Found: 373.0.A solution of the amide intermediate in acetic acid (0.3 mL) was stirred at 105° C. for 5 h. The solvent in the reaction mixture was removed in vacuo, diluted with MeOH and purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (6 mg, 10%).", "LCMS calculated for C19H23N4OS (M+H)+: m/z=355.2; Found: 355.1.Example 9.", "(1R)-1-[1-(3-Fluoropiperidin-4-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl]ethanol Step 1.tert-Butyl 3-hydroxy-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.61 g, 2.8 mmol) (Example 1, Step 2), tert-butyl 4-amino-3-hydroxypiperidine-1-carboxylate (from Aurora, 0.95 g, 4.4 mmol) and N,N-diisopropylethylamine (0.99 mL, 5.7 mmol) in isopropyl alcohol (7.4 mL) was heated at 90° C. for 2 h. The resulting mixture was diluted with water.", "The precipitate was collected by filtration, washed with water and air-dried to give the desired product (1 g, 89%).", "LCMS calculated for C17H23N4O5S (M+H)+: m/z=395.1; Found: 395.0.Step 2.tert-Butyl 3-fluoro-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate To a solution of tert-butyl 3-hydroxy-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate (716 mg, 1.82 mmol) in methylene chloride (4 mL) cooled at 0° C. was added slowly 2-methoxy-N-(2-methoxyethyl)-N-(trifluoro-λ(4)-sulfanyl)ethanamine (0.50 mL, 2.7 mmol).", "The reaction was stirred at room temperature for 4 h. The mixture was diluted with dichloromethane, washed with water, and concentrated.", "The residue was purified on silica gel (eluting with 0 to 30% EtOAc in dichloromethane) to give the desired product (0.32 g, 44%) as a mixture of cis- and trans-isomers mixture.", "LCMS calculated for C17H22FN4O4S (M+H)+: m/z=397.1; Found: 397.1.Step 3.tert-Butyl 4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-3-fluoropiperidine-1-carboxylate A mixture of tert-butyl 3-fluoro-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate (0.32 g, 0.81 mmol) and 10% palladium on carbon (80 mg) in methanol (8 mL) was hydrogenated under balloon pressure of H2 at room temperature for 5 h. The reaction mixture was filtered, and the filtrate was concentrated to give the desired product (0.23 g, 78%) as a mixture of cis- and trans-isomers mixture.", "LCMS calculated for C17H24FN4O2S (M+H)+: m/z=367.2; Found: 367.1.Step 4.", "(1R)-1-[1-(3-Fluoropiperidin-4-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl]ethanol To a mixture of tert-butyl 4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-3-fluoropiperidine-1-carboxylate (0.21 g, 0.57 mmol) and (R)-2-hydroxypropanoic acid (0.059 g, 0.65 mmol) in methylene chloride (5 mL) was added N,N-diisopropylethylamine (0.23 mL, 1.3 mmol) and N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (0.23 g, 0.60 mmol).", "The resulting mixture was stirred at room temperature overnight.", "The reaction mixture was washed with water, concentrated and purified on silica gel (eluting with 0 to 10% MeOH in dichloromethane) to give tert-butyl 3-fluoro-4-[(6-{[(2R)-2-hydroxypropanoyl]amino}thieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate (0.155 g, 62%).", "LCMS calculated for C20H28FN4O4S (M+H)+: m/z=439.2; Found: 439.1.A solution of the amide intermediate in acetic acid (1 mL) was heated at reflux for 2 h. The resulting mixture was purified on silica gel (eluting with 0-10% MeOH in dichloromethane) to give tert-butyl 3-fluoro-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidine-1-carboxylate (16 mg, 10%).", "LCMS calculated for C20H26FN4O3S (M+H)+: m/z=421.2; Found: 421.1.The Boc protected intermediate was treated with trifluoroacetic acid (0.1 mL, 1 mmol) in methylene chloride (0.2 mL) at room temperature for 1 h. The mixture was concentrated and purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give two desired products.", "First peak retention time 0.253 min.", "LCMS calculated for C15H18FN4OS (M+H)+: m/z=321.1; Found: 321.1.Second peak retention time 0.514 min.", "LCMS calculated for C15H18FN4OS (M+H)+: m/z=321.1; Found: 321.1.Example 10.", "(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile HCl salt Step 1.", "{trans-4-[(tert-Butoxycarbonyl)amino]cyclohexyl}methyl methanesulfonate A mixture of tert-butyl [trans-4-(hydroxymethyl)cyclohexyl]carbamate (from Albany Molecular, 1.5 g, 6.5 mmol) in methylene chloride (20 mL) was treated with pyridine (2.14 mL, 26.5 mmol).", "The mixture was cooled to 0° C. and methanesulfonyl chloride (1.01 mL, 13.1 mmol) was added dropwise over 5 min.", "The reaction was stirred at room temperature for 5 h. The resulting mixture was then concentrated and partitioned between EtOAc and water.", "The organic phases were concentrated and purified on silica gel (eluting with 50% EtOAc in hexanes) to give the desired product (1.48 g, 74%).", "LCMS calculated for C13H25NO5SNa (M+Na)+: m/z=330.2; Found: 330.0.Step 2.", "(trans-4-Aminocyclohexyl)acetonitrile trifluoroacetate A mixture of {trans-4-[(tert-butoxycarbonyl)amino]cyclohexyl}methyl methanesulfonate (1.48 g, 4.81 mmol) and sodium cyanide (0.46 g, 9.4 mmol) in dimethyl sulfoxide (20 mL) was stirred at 90° C. for 4 h. After cooling, the mixture was partitioned between EtOAc and brine.", "The organic layer was washed with water, concentrated and purified on silica gel (eluting with 50% EtOAc in hexanes) to give tert-butyl [trans-4-(cyanomethyl)cyclohexyl]carbamate.", "LCMS calculated for C13H22N2O2Na (M+Na)+: m/z=261.2; Found: 261.1.A solution of the Boc-protected intermediate in methylene chloride (20 mL) was treated with trifluoroacetic acid (3 mL, 40 mmol) and the resulting mixture was stirred at room temperature for 2 h, then concentrated to give the desired product as TFA salt.", "LCMS calculated for C8H15N2 (M+H)+: m/z=139.1; Found: 139.1.Step 3.", "{trans-4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile To a stirred suspension of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.88 g, 4.1 mmol) in isopropyl alcohol (14 mL), (trans-4-aminocyclohexyl)acetonitrile TFA salt (0.68 g, 4.9 mmol) and N,N-diisopropylethylamine (3.0 mL, 17 mmol) were added.", "The reaction was stirred at 90° C. for 2 h. The mixture was concentrated and purified on silica gel (eluting with 0 to 60% EtOAc in dichloromethane) to give the desired product (1 g, 77%).", "LCMS calculated for C15H17N4O2S (M+H)+: m/z=317.1; Found: 317.0.Step 4.", "{trans-4-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile A mixture of {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (1.0 g, 3.2 mmol) and 10% palladium on carbon (0.3 g, 0.3 mmol) in methanol (30 mL) was hydrogenated under balloon pressure of H2 at room temperature for 5 h. The reaction mixture was filtered.", "The filtrate was concentrated, diluted with dichlormethane, dried over MgSO4, and concentrated.", "The residue was purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product.", "(0.63 g, 70%).", "LCMS calculated for C15H19N4S (M+H)+: m/z=287.1; Found: 287.1.Step 5.", "(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile A mixture of (2R)-2-hydroxypropanamide (0.630 g, 7.07 mmol) and triethyloxonium tetrafluoroborate (1.26 g, 6.66 mmol) in tetrahydrofuran (9.7 mL) was stirred at room temperature for 2 h. The solvent was removed, and the residue dissolved in ethanol (4.1 mL) and added to a suspension of {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (0.63 g, 2.2 mmol) in ethanol (15 mL).", "The reaction was stirred at 80° C. for 2 h. The solvent was removed and the residue was partitioned between EtOAc and sat.", "NaHCO3 solution.", "The organic phase was washed with brine, dried over MgSO4, and concentrated.", "The residue was purified on silica gel (eluting with 0 to 10% MeOH in dichloromethane), then further purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (0.55 g, 73%).", "LCMS calculated for C18H21N4OS (M+H)+: m/z=341.1; Found: 341.1.Step 6.", "(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile HCl salt (trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile (0.154 g, 0.451 mmol) was dissolved in acetonitrile (10 mL).", "1.0 M Hydrogen chloride in water (0.480 mL, 0.480 mmol) was added slowly with stirring, followed by addition of water (10 mL).", "The mixture was stirred at room temperature until becoming homogeneous.", "The resulting solution was lyophilized to give the desired product as HCl salt.", "(0.169 g, 99.5%).", "LCMS calculated for C8H21N4OS (M+H)+: m/z=341.1; Found: 341.1.1H NMR (DMSO-d6, 500 MHz) δ 9.55 (1H, s), 8.47 (1H, d, J=5.5 Hz), 8.00 (1H, d, J=5.5 Hz), 5.32 (1H, m), 5.07 (1H, m), 2.62 (2H, d, J=6.0 Hz), 2.43 (2H, m), 2.12 (2H, m), 2.04 (3H, m), 1.68 (3H, d, J=6.0 Hz), 1.46 (2H, m) ppm.", "Example 11.", "(1R)-1-{1-[trans-4-(Hydroxymethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol Step 1.", "{trans-4-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methanol A mixture of {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methanol (0.080 g, 0.26 mmol) (Example 2, Step 1) and 10% palladium on carbon (0.03 g) in methanol (3 mL) was hydrogenated under balloon pressure of H2 at room temperature for 1 h. The mixture was filtered.", "The filtrate was concentrated, diluted with dichloromethane, then dried over MgSO4, and concentrated.", "The residue was purified on silica gel (eluting with 10% MeOH in dichloromethane) to give the desired product (41 mg, 57%).", "LCMS calculated for C14H20N3OS (M+H)+: m/z=278.1; Found: 278.1.Step 2.", "(1R)-1-{1-[trans-4-(Hydroxymethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol A mixture of (2R)-2-hydroxypropanamide (42 mg, 0.48 mmol) and triethyloxonium tetrafluoroborate (85 mg, 0.45 mmol) in tetrahydrofuran (0.65 mL) was stirred at room temperature for 2 h. The solvent was removed, and the residue dissolved in ethanol (0.27 mL) and added to a suspension of {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methanol (41 mg, 0.15 mmol) in ethanol (0.99 mL).", "The resulting mixture was stirred at 85° C. for 1 h. The solvent was removed and the residue was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (2.3 mg, 4.7%).", "LCMS calculated for C17H22N3O2S (M+H)+: m/z=332.1; Found: 332.1.Example 12.", "(1R)-1-{1-[trans-4-(Fluoromethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol Step 1.N-[trans-4-(Fluoromethyl)cyclohexyl]-6-nitrothieno[3,2-b]pyridin-7-amine To a solution of {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methanol (0.30 g, 0.98 mmol) in methylene chloride (2 mL) cooled at 0° C. was added slowly 2-methoxy-N-(2-methoxyethyl)-N-(trifluoro-λ(4)-sulfanyl)ethanamine (0.27 mL, 1.5 mmol).", "The resulting mixture was stirred at room temperature for 4 h. The mixture was diluted with dichloromethane, washed with water, and concentrated.", "The residue was purified on silica gel (eluting with 0-30% EtOAc in dichloromethane) to give the desired product (0.2 g, 70%).", "LCMS calculated for C14H17FN3O2S (M+H)+: m/z=310.1; Found: 310.0.Step 2.N7-[trans-4-(Fluoromethyl)cyclohexyl]thieno[3,2-b]pyridine-6,7-diamine A mixture of N-[trans-4-(fluoromethyl)cyclohexyl]-6-nitrothieno[3,2-b]pyridin-7-amine (0.20 g, 0.65 mmol) and 10% palladium on carbon (0.07 g) in methanol (7 mL) was hydrogenated under balloon pressure of H2 at room temperature for 1 h. The mixture was filtered.", "The filtrate was concentrated, diluted with dichloromethane, and then dried over MgSO4 and concentrated to give the desired product (0.11 g, 61%).", "LCMS calculated for Cl4H19FN3S (M+H)+: m/z=280.1; Found: 280.1.Step 3.", "(1R)-1-{1-[trans-4-(Fluoromethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol A mixture of (2R)-2-hydroxypropanamide (0.184 g, 2.07 mmol) and triethyloxonium tetrafluoroborate (0.371 g, 1.95 mmol) in tetrahydrofuran (2.8 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (1.2 mL) and added to a suspension of N7-[trans-4-(fluoromethyl)cyclohexyl]thieno[3,2-b]pyridine-6,7-diamine (0.18 g, 0.64 mmol) in ethanol (4.3 mL).", "The resulting mixture was stirred at 80° C. for 1 h. The solvent was removed and the residue was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (0.10 g, 50%).", "LCMS calculated for C17H21FN3OS (M+H)+: m/z=334.1; Found: 334.1.Example 13.", "(1R)-1-(1-Cyclohexyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol Step 1.N-Cyclohexyl-6-nitrothieno[3,2-b]pyridin-7-amine A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.055 g, 0.26 mmol) (Example 1, Step 2), cyclohexanamine (59 μL, 0.51 mmol) and N,N-diisopropylethylamine (0.13 mL, 0.77 mmol) in isopropyl alcohol (0.87 mL) was heated at 90° C. for 2 h. The resulting mixture was concentrated to give the desired product, which was used directly in the next step.", "LCMS calculated for C13H16N3O2S (M+H)+: m/z=278.1; Found: 278.0.Step 2.N7-Cyclohexylthieno[3,2-b]pyridine-6,7-diamine A mixture of N-cyclohexyl-6-nitrothieno[3,2-b]pyridin-7-amine (0.065 g, 0.23 mmol) and 10% palladium on carbon (0.02 g) in methanol (3 mL) was hydrogenated under balloon pressure of H2 at room temperature for 1 h. The reaction mixture was filtered.", "The filtrate was concentrated, diluted with dichloromethane, dried over MgSO4, and concentrated.", "The residue was purified on silica gel (eluting with 0 to 10% MeOH in dichloromethane) to give the desired product (42 mg, 72%).", "LCMS calculated for C13H18N3S (M+H)+: m/z=248.1; Found: 248.1.Step 3.", "(1R)-1-(1-Cyclohexyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol A mixture of (2R)-2-hydroxypropanamide (49 mg, 0.55 mmol) and triethyloxonium tetrafluoroborate (98 mg, 0.51 mmol) in tetrahydrofuran (0.75 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (0.32 mL) and added to a suspension of N7-cyclohexylthieno[3,2-b]pyridine-6,7-diamine (42 mg, 0.17 mmol) in ethanol (1.1 mL).", "The reaction mixture was stirred at 80° C. for 1 h. The solvent was removed, and the residue was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (1 mg, 2%).", "LCMS calculated for C16H20N3OS (M+H)+: m/z=302.1; Found: 302.1.Example 14.1-(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)-N-methylmethanesulfonamide Step 1.", "{trans-4-[(tert-Butoxycarbonyl)amino]cyclohexyl}methyl 4-methylbenzenesulfonate To a solution of tert-butyl [trans-4-(hydroxymethyl)cyclohexyl]carbamate (0.50 g, 2.2 mmol) (Supplier: Chem-Impex) in methylene chloride (15 mL) was added triethylamine (1.29 mL, 9.27 mmol), 4-dimethylaminopyridine (53 mg, 0.44 mmol), and p-toluenesulfonyl chloride (0.89 g, 4.7 mmol).", "The resulting mixture was stirred at room temperature for 2 h before adding more p-toluenesulfonyl chloride (0.42 g, 2.2 mmol).", "The mixture was stirred overnight.", "Water and dichloromethane were added and the layers separated.", "The aqueous was extracted with dichloromethane.", "The combined organics were washed with water and brine, dried (MgSO4), filtered, and concentrated.", "The residue was purified on Biotage Isolera (40 g Agela cartridge, eluted with 5-50% EtOAc/hexanes over 15 min) to give the desired product (0.72 g, 86%) as a white crystalline solid.", "LCMS calculated for C19H29NO5SNa (M+Na)+: m/z=406.2; Found: 406.0.Step 2.S-({trans-4-[(tert-Butoxycarbonyl)amino]cyclohexyl}methyl) ethanethioate To a mixture of {trans-4-[(tert-butoxycarbonyl)amino]cyclohexyl}methyl 4-methylbenzenesulfonate (0.72 g, 1.9 mmol) in dimethyl sulfoxide (6.0 mL) was added a solution of potassium thioacetate (0.242 g, 2.12 mmol) in dimethyl sulfoxide (1.0 mL).", "The resulting mixture was stirred at 55° C. for 3 h. After cooling, the reaction was quenched by adding sat.", "NaHCO3.After stirring briefly, the solids that formed were filtered and washed with water to give 0.52 g (96%) of the desired product.", "LCMS calculated for C9H18NOS (M+H-Boc+H)+: m/z=188.1; Found: 188.2.Step 3.S-[(trans-4-Aminocyclohexyl)methyl] ethanethioate trifluoroacetate A mixture of S-({trans-4-[(tert-Butoxycarbonyl)amino]cyclohexyl}methyl) ethanethioate (0.20 g, 0.70 mmol) in methylene chloride (1.6 mL) was treated with trifluoroacetic acid (0.54 mL, 7.0 mmol) at room temperature for 2 h. The reaction mixture was evaporated to dryness to give the desired product (0.21 g, 100%).", "LCMS calculated for C9H18NOS (M+H)+: m/z=188.1; Found: 188.1.Step 4.S-({trans-4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methyl) ethanethioate A mixture of S-[(trans-4-Aminocyclohexyl)methyl] ethanethioate trifluoroacetate (0.21 g, 0.70 mmol), 7-chloro-6-nitrothieno[3,2-b]pyridine (0.11 g, 0.51 mmol), and N,N-diisopropylethylamine (0.27 mL, 1.5 mmol) in isopropyl alcohol (1.6 mL) was heated at 90° C. for 2 h. The mixture was concentrated under reduced pressure.", "The residue was treated with water to form a solid which was collected by filtration and washed with water to give the desired product (0.12 g, 64%).", "LCMS calculated for C16H20N3O3S2 (M+H)+: m/z=366.1; Found: 366.1.1H NMR (DMSO-d6, 400 MHz) δ 9.07 (1H, s), 9.03 (1H, d, J=8.8 Hz), 8.35 (1H, d, J=5.6 Hz), 7.51 (1H, d, J=5.6 Hz), 4.13 (1H, m), 2.83 (2H, d, J=6.4 Hz), 2.34 (3H, s), 2.13 (2H, m), 1.83 (2H, m), 1.51 (3H, m), 1.19 (2H, m) ppm.", "Step 5.", "{trans-4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methanesulfonic acid A mixture of hydrogen peroxide (30%, 110 μL, 1.1 mmol) was added to formic acid (0.43 mL), and the resulting mixture stirred for 30 min before adding S-({trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methyl) ethanethioate (67 mg, 0.18 mmol).", "The resulting mixture was stirred at room temperature overnight.", "The reaction was quenched with a small amount of 0.3 M sodium metabisulfite solution.", "The pH of the mixture was adjusted to ˜5 by adding 50% NaOH, which caused a solid to crash out.", "The solid was filtered and washed with ether to give the desired product (68 mg) which was used directly in the next step without further purification.", "LCMS calculated for C14H18N3O5S2 (M+H)+: m/z=372.1; Found: 372.1.Step 6.N-Methyl-1-{trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methanesulfonamide To a mixture of {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methanesulfonic acid (34 mg, 0.092 mmol) in methylene chloride (0.30 mL) was added 1 drop of DMF and thionyl chloride (33 μL, 0.46 mmol).", "The resulting mixture was stirred at 42° C. for 1 h, then the solvents were evaporated to give the crude {trans-4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methanesulfonyl chloride.", "To the crude sulfonyl chloride made above was added 2.0 M methylamine in THF (0.30 mL, 0.60 mmol).", "The mixture was stirred at room temperature for 30 h. LCMS showed a small amount of starting material remaining.", "More 2.0 M methylamine in THF (0.15 mL) was added and stirred for 30 min, to give a complete reaction.", "The solvents were evaporated and the resultant residue was dried in vacuo to give the crude product which was used in the next step without further purification.", "LCMS calculated for C15H21N4O4S2 (M+H)+: m/z=385.1; Found: 385.1.Step 7.1-{trans-4-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}-N-methylmethanesulfonamide A mixture of N-methyl-1-{trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methanesulfonamide (35 mg, 0.091 mmol) and 10% palladium on carbon (10 mg) in methanol (1.0 mL) was stirred under an atmosphere of H2 for 10 h. The mixture was filtered through Celite.", "The filtrate was concentrated under reduced pressure to give the desired product (32 mg).", "LCMS calculated for C15H23N4O2S2 (M+H)+: m/z=355.1; Found: 355.1.Step 8.1-(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)-N-methylmethanesulfonamide A mixture of (2R)-2-hydroxypropanamide (25.8 mg, 0.290 mmol) and triethyloxonium tetrafluoroborate (51.9 mg, 0.273 mmol) in tetrahydrofuran (0.40 mL) was stirred at room temperature for 1 h. After evaporated to dry under reduced pressure, the clear oil was mixed with ethanol (0.20 mL, 3.4 mmol) and added to a solution of 1-{trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}-N-methylmethanesulfonamide (32 mg, 0.090 mmol) in ethanol (0.60 mL) in a microwave vial.", "The mixture was then heated at 80° C. for 1 h. The mixture was concentrated under reduced pressure.", "The resultant residue was purified using prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (9.8 mg, 26%).", "LCMS calculated for C18H25N4O3S2 (M+H)+: m/z=409.1; Found: 409.1.Example 15.", "(1R)-1-{1-[1-(2,2,2-Trifluoroethyl)piperidin-4-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol Step 1.tert-Butyl 4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.48 g, 2.2 mmol) (Example 1, Step 2), tert-butyl 4-aminopiperidine-1-carboxylate (from Aldrich, 0.67 g, 3.4 mmol) and N,N-diisopropylethylamine (1.2 mL, 6.7 mmol) in isopropyl alcohol (7.6 mL) was heated at 90° C. for 2 h. The precipitate was washed with isopropyl alcohol to give the desired product (0.70 83%).", "LCMS calculated for C17H23N4O4S (M+H)+: m/z=379.1; Found: 379.2.Step 2.tert-Butyl 4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate A mixture of tert-butyl 4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate (0.70 g, 1.8 mmol) and 10% palladium on carbon (0.2 g) in methanol (20 mL) was subjected to balloon pressure of H2 at room temperature for 5 h. The reaction mixture was filtered and concentrated and to give the desired product (0.64 g, 100%).", "LCMS calculated for C17H25N4O2S (M+H)+: m/z=349.2; Found: 349.1.Step 3.tert-Butyl 4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidine-1-carboxylate A mixture of (2R)-2-hydroxypropanamide (0.468 g, 5.26 mmol) and triethyloxonium tetrafluoroborate (0.941 g, 4.95 mmol) in tetrahydrofuran (7.2 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (3.0 mL) and added to a suspension of tert-butyl 4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate (0.57 g, 1.6 mmol) in ethanol (11 mL).", "The mixture was stirred at 80° C. for 1 h. The solvent was removed and the residue was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (85 mg, 13%).", "LCMS calculated for C20H27N4O3S (M+H)+: m/z=403.2; Found: 403.2.Step 4.", "(1R)-1-(1-Piperidin-4-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol hydrochloride To a solution of tert-butyl 4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidine-1-carboxylate (71 mg, 0.18 mmol) in methylene chloride (1.2 mL) was added 4.0 M hydrogen chloride in dioxane (0.35 mL, 1.4 mmol).", "The reaction solution was stirred at room temperature for 6 h. The solvent was removed to give the desired product as white solid (60 mg, 100%).", "LCMS calculated for C15H19N4OS (M+H)+: m/z=303.1; Found: 303.1.Step 5.", "(1R)-1-{1-[1-(2,2,2-Trifluoroethyl)piperidin-4-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol To a mixture of (1R)-1-(1-piperidin-4-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol hydrochloride (21.6 mg, 0.0637 mmol) and triethylamine (40.0 μL, 0.287 mmol) in methylene chloride (0.78 mL) was added 2,2,2-trifluoroethyl trifluoromethanesulfonate (17.8 mg, 0.0765 mmol).", "The resulting mixture was stirred overnight at room temperature.", "The solvents were evaporated, and the crude residue purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 6.5 mg (26%) of the desired product.", "LCMS calculated for C17H20F3N4OS (M+H)+: m/z=385.1; Found: 385.0.Example 16.3-(4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidin-1-yl)propanenitrile To a solution of (1R)-1-(1-piperidin-4-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol hydrochloride (21.7 mg, 0.0640 mmol) (Example 15, Step 4) in acetonitrile (0.40 mL) was added 2-propenenitrile (8.4 μL, 0.13 mmol), followed by 1,8-diazabicyclo[5.4.0]undec-7-ene (38 μL, 0.26 mmol).", "The resulting mixture was stirred at room temperature overnight.", "After evaporating to dryness, the residue was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (11 mg, 48%).", "LCMS calculated for C18H22N5OS (M+H)+: m/z=356.2; Found: 356.0.Example 17.", "{trans-4-[2-(Hydroxymethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile A mixture of {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (51.9 mg, 0.181 mmol) (Example 2, Step 4) and 2-chloro-1,1,1-triethoxyethane (from Aldrich, 0.105 mL, 0.549 mmol) in acetic acid (0.5 mL) was stirred at 120° C. for 30 min.", "The solvent was removed and the resultant residue dissolved in dichloromethane and purified on silica gel (eluting with 0-5% MeOH in dichloromethane) to give 22 mg (35.5%) of {trans-4-[2-(Chloromethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile.", "LCMS calculated for C17H8ClN4S (M+H)+: m/z=345.1; Found: 345.0.Also eluted was 8 mg (12%) of {1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl acetate, LCMS calculated for C19H21N4O2S (M+H)+: m/z=369.1; Found: 369.0.The acetate compound was treated with lithium hydroxide to give compound the desired product after HPLC purification (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min).", "LCMS calculated for C17H19N4OS (M+H)+: m/z=327.1; Found: 327.1.H NMR (500 MHz, DMSO-d6) δ 8.96 (s, 1H), 8.01 (d, J=5.5 Hz, 1H), 7.67 (d, J=5.5 Hz, 1H), 5.80 (t, J=5.6 Hz, 1H), 4.85 (d, J=5.3 Hz, 2H), 4.74 (m, 1H), 2.61 (d, J=6.1 Hz, 2H), 2.42 (m, 2H), 2.09-1.99 (m, 5H), 1.41 (m, 2H) ppm.", "Example 18.N-({1-[trans-4-(Cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl)methanesulfonamide Step 1.tert-Butyl (Methylsulfonyl)Carbamate Triethylamine (2.2 mL, 16 mmol), di-tert-butyldicarbonate (2.65 g, 12.1 mmol) and 4-dimethylaminopyridine (0.096 g, 0.79 mmol) were added sequentially to a solution of methanesulfonamide (0.75 g, 7.9 mmol) in methylene chloride (20 mL) at room temperature.", "The reaction was stirred at room temperature for 2 h and then concentrated.", "EtOAc was added, and the resultant mixture was washed with 1N aq.", "HCl solution, dried over MgSO4 and concentrated to give the desired product (1 g) to be used in the next step directly.", "Step 2.N-({1-[trans-4-(Cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl)methanesulfonamide To a solution of {trans-4-[2-(chloromethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile (from example 17, 22.2 mg, 0.0644 mmol) dissolved in N,N-dimethylformamide (0.2 mL) was added tert-butyl (methylsulfonyl)carbamate (19 mg, 0.096 mmol) and potassium carbonate (18 mg, 0.13 mmol).", "The reaction was stirred at 50° C. overnight.", "The mixture was diluted with water, extracted with EtOAc.", "The combined organic layers were dried over MgSO4 and concentrated to give tert-butyl ({1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl)(methylsulfonyl)carbamate.", "LCMS calculated for C23H30N5O4S2 (M+H)+: m/z=504.2; Found: 504.1.This crude intermediate was treated with trifluoroacetic acid (0.1 mL, 1 mmol) in methylene chloride (0.1 mL) at room temperature for 30 min, and then the solvent was removed in vacuo.", "The residue was then dissolved in MeOH and purified on prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (9.5 mg, 36%).", "LCMS calculated for C18H22N5O2S2 (M+H)+: m/z=404.1; Found: 404.0.Example 19.", "(1R)-1-{1-[(3S)-6-(Hydroxymethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol Step 1.tert-Butyl (4S)-2,2-dimethyl-4-vinyl-1,3-oxazolidine-3-carboxylate To a suspension of methyl triphenylphosphonium bromide (5.63 g, 15.8 mmol) in tetrahydrofuran (140 mL) was added 2.5 M n-butyllithium in hexane (7.35 mL, 18.4 mmol).", "The deep red solution was stirred at 0° C. for 1 h. Then a solution of tert-butyl (4R)-4-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate (from Aldrich, 3.01 g, 13.1 mmol) in tetrahydrofuran (7.3 mL) was added drop wise at 0° C. The red solution was warmed to room temperature and stirred for 12 h. Hexanes was added to the reaction mixture in 4:1 (v/v) ratio.", "The suspension was filtered through Celite and the filtrate concentrated.", "The resultant residue was purified by flash chromatography (eluting with 10% ethyl acetate in hexanes) to give the desired compound as colorless oil (1.92 g, 64%).", "Step 2.tert-Butyl [(1S)-1-(hydroxymethyl)prop-2-en-1-yl]carbamate To a solution of tert-butyl (4S)-2,2-dimethyl-4-vinyl-1,3-oxazolidine-3-carboxylate (1.90 g, 8.36 mmol) in methanol (83 mL) was added p-toluenesulfonic acid monohydrate (0.80 g, 4.2 mmol) at 0° C. The mixture was slowly warmed to room temperature overnight.", "The reaction mixture was diluted with saturated NaHCO3 solution, concentrated, and then diluted with ethyl acetate.", "The organic layer was washed with sat.", "NaHCO3 (2×) and brine, dried over Na2SO4, filtered and concentrated to give the desired product as colorless oil (1.187 g, 76%).", "1H NMR (400 MHz, CDCl3) δ 5.81 (1H, m), 5.25 (2H, m), 4.90 (1H, m), 4.25 (1H, br s), 3.67 (2H, m), 1.45 (9H, s) ppm.", "Step 3.tert-Butyl [(1S)-1-({[1-(hydroxymethyl)prop-2-en-1-yl]oxy}methyl)prop-2-en-1-yl]carbamate To a flask was charged with tert-butyl [(1S)-1-(hydroxymethyl)prop-2-en-1-yl]carbamate (0.401 g, 2.14 mmol), tris(dibenzylideneacetone)dipalladium(0) (59 mg, 0.064 mmol), N,N′-(1S,2S)-cyclohexane-1,2-diylbis[2-(diphenylphosphino)-1-naphthamide] (150 mg, 0.19 mmol), and 4-dimethylaminopyridine (78 mg, 0.64 mmol).", "The reaction mixture was purged with N2 three times, and then methylene chloride (21.3 mL), and 1.0 M triethylborane in THF (130 μL, 0.13 mmol) was added sequentially.", "After stirring for 10 min, 2-vinyloxirane (0.150 g, 2.14 mmol) was added and the resulting mixture was stirred overnight.", "The reaction was diluted with dichloromethane and sat.", "NaHCO3 solution.", "The organic layer was separated and dried over Na2SO4, filtered and concentrated.", "The crude residue was purified with flash chromatography (eluting with 0-50% ethyl acetate/hexanes) to give the desired product (0.271 g, 49%).", "1H NMR (300 MHz, CDCl3) δ 5.85 (1H, m), 5.67 (1H, m), 5.84-5.17 (4H, m), 4.83 (1H, m), 4.30 (1H, br s), 3.83 (1H, m), 3.69 (1H, dd, J=4.5 and 6.9 Hz), 3.54 (2H, m), 3.36 (1H, dd, J=4.5 and 6.9 Hz), 1.45 (9H, s) ppm.", "Step 4.2-({(2S)-2-[(tert-Butoxycarbonyl)amino]but-3-en-1-yl}oxy)but-3-en-1-yl acetate To a mixture of tert-butyl [(1S)-1-({[1-(hydroxymethyl)prop-2-en-1-yl]oxy}methyl)prop-2-en-1-yl]carbamate (268 mg, 1.04 mmol) in methylene chloride (10 mL) was added with triethylamine (435 μL, 3.12 mmol).", "The mixture was cooled to 0° C., and acetyl chloride (150 μL, 2.1 mmol) was added drop wise.", "The reaction was stirred at room temperature for 2 h, then quenched with water.", "The organic layer was concentrated and the resultant residue purified on silica gel (eluting with 20% ethyl acetate/hexanes) to give the desired product (0.26 g, 85%).", "LCMS calculated for C10H5NO3 (M−100+H)+: m/z=200.1; Found: 200.1.Step 5.", "{(5S)-5-[(tert-Butoxycarbonyl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate To a 500 mL 2-neck round bottom flask, benzylidene(dichloro)(1,3-dimesitylimidazolidin-2-id-2-yl)(tricyclohexylphosphoranyl)ruthenium (38 mg, 0.044 mmol) was added.", "After purged with nitrogen for 3 times, dichloromethane (anhydrous, 8 mL) was added followed by 2-({(2S)-2-[(tert-butoxycarbonyl)amino]but-3-en-1-yl}oxy)but-3-en-1-yl acetate (265 mg, 0.885 mmol).", "The reaction mixture was stirred at room temperature for 15 h. The mixture was concentrated in vacuo.", "The residue was purified via flash chromatography (eluting with hexanes to 25% EtOAc in hexanes) to give the desired product as a brown oil (0.205 g, 85%).", "LCMS calculated for C9H14NO5 (M+H-Bu+H)+: m/z=216.1; Found: 216.1.1H NMR (300 MHz, CDCl3) δ 5.94 (0.17H, m), 5.84 (0.83H, m), 5.69 (1H, m), 4.89 (0.13H, m), 4.70 (0.83H, m), 4.25 (1H, m), 4.05 (4H, m), 3.56 (0.13H, m), 3.38 (0.87H, m), 2.04 (2.49H, s), 2.03 (0.51H, m), 1.38 (9H, s) ppm (The product was a ˜5:1 mixture of trans- and cis-isomers).", "Step 6.", "[(5S)-5-Amino-5,6-dihydro-2H-pyran-2-yl]methyl acetate To a solution of {(5S)-5-[(tert-butoxycarbonyl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate (205 mg, 0.756 mmol) in methylene chloride (5.2 mL) was added 4.0 M hydrogen chloride in dioxane (1.5 mL, 6.0 mmol).", "The reaction solution was stirred at room temperature for 6 h. The solvent was removed under reduced pressure to give the desired product as white solid.", "LCMS calculated for C8H4NO3 (M+H)+: m/z=172.1; Found: 172.1.Step 7.", "{(5S)-5-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (156 mg, 0.727 mmol), [(5S)-5-amino-5,6-dihydro-2H-pyran-2-yl]methyl acetate (129 mg, 0.754 mmol) and N,N-diisopropylethylamine (0.26 mL, 1.5 mmol) in isopropyl alcohol (1.7 mL) was heated at 90° C. for 2 h. The reaction mixture was concentrated and purified with flash chromatography to give the desired product (0.21 g 83%).", "LCMS calculated for C15H16N3O5S (M+H)+: m/z=350.1; Found: 350.0.Step 8.", "{(5S)-5-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}methyl acetate A mixture of {(5S)-5-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate (210 mg, 0.600 mmol) and 10% palladium on carbon (0.21 g) in methanol (4.0 mL) was subjected to balloon pressure of H2 at room temperature for 2 h. The mixture was filtered, and the filtrate was concentrated and purified with flash chromatography (eluting with 15% methanol in dichloromethane) to give the desired product (145 mg, 75%).", "LCMS calculated for C15H20N3O3S (M+H)+: m/z=322.1; Found: 322.0.Step 9.", "(1R)-1-{1-[(3S)-6-(Hydroxymethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol A mixture of (2R)-2-hydroxypropanamide (131 mg, 1.47 mmol) and triethyloxonium tetrafluoroborate (263 mg, 1.38 mmol) in THF (2 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (0.85 mL) and added to a suspension of {(5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}methyl acetate (145 mg, 0.451 mmol) in ethanol (3.1 mL).", "The mixture was stirred at 80° C. for 1 h. The reaction was cooled to room temperature and diluted with water (1.0 mL).", "Lithium hydroxide (32.4 mg, 1.35 mmol) was added, and the mixture was stirred for 2 h. The reaction mixture was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product as white solid (95 mg, 63%).", "LCMS calculated for C16H20N3O3S (M+H)+: m/z=334.1; Found: 334.0.Example 20.", "((2R,5S)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile Step 1: ((2R,5S)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate and ((2S,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate To a solution of (1R)-1-{1-[(3S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol (100 mg, 0.300 mmol) (Example 19, Step 9) in methylene chloride (3.4 mL) and pyridine (0.146 mL, 1.80 mmol) was added p-toluenesulfonyl chloride (57.2 mg, 0.300 mmol) and 4-dimethylaminopyridine (1.8 mg, 0.015 mmol) at 0° C. The reaction mixture was allowed to warm to room temperature overnight.", "The reaction mixture was concentrated, diluted with methanol, and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give two peaks.", "On analytic HPLC (Waters SunFire C18, 2.1×50 mm, 5 μM; Flow rate 3 mL/min; Injection volume 2 μL; At gradient from 2 to 80% B in 3 minutes (A=water with 0.025% TFA, B=acetonitrile)): First peak (45.3 mg, 31%) retention time 1.81 min, LCMS calculated for C23H26N3O5S2 (M+H)+: m/z=488.1; Found: 488.1.Second peak (8.5 mg, 5.8%) retention time 1.88 min, LCMS calculated for C23H26N3O5S2 (M+H)+: m/z=488.1; Found: 488.1.Step 2.", "((2R,5S)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile A mixture of ((2R,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate (from 1st peak of previous step, 27 mg, 0.055 mmol) and sodium cyanide (4.5 mg, 0.092 mmol) in dimethyl sulfoxide (0.4 mL) was stirred at 50° C. for 4 h. After cooling, the mixture was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (14.5 mg, 76%).", "LCMS calculated for C17H19N4O2S (M+H)+: m/z=343.1; Found: 343.0.1H NMR (DMSO-d6, 500 MHz) δ 9.51 (1H, s), 8.45 (1H, d, J=5.5 Hz), 7.97 (1H, d, J=5.5 Hz), 5.31 (1H, m), 5.20 (1H, m), 4.31 (1H, m), 4.23 (1H, m), 4.02 (1H, m), 2.96 (1H, dd, J=17.0 and 4.5 Hz), 2.85 (1H, dd, J=17.0 and 4.5 Hz), 2.66 (1H, m), 2.26 (1H, m), 2.09 (1H, m), 1.73 (1H, m), 1.69 (3H, d, J=6.5 Hz) ppm.", "Example 20a.", "((2R,5S)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile hydrate ((2R,5S)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile (52 mg, 0.15 mmol) from Example 20 was crystallized from a mixture of acetonitrile (8 mL) and water (4 mL).", "The resulting colorless prism crystal collected was suitable for X-ray crystal structure analysis.", "Crystal data shows: ˜0.520×0.180×0.100 mm, orthorhombic, P212121, a=6.962(3) Å, b=11.531(4) Å, c=20.799(7) Å, Vol=1669.6(10) Å3, Z=4, T=−100.° C., Formula weight=359.42, Density=1.430 g/cm3, μ(Mo)=0.22 mm−1 Data collection was done on a Bruker SMART APEX-II CCD system, MoKalpha radiation, standard focus tube, anode power=50 kV×42 mA, crystal to plate distance=5.0 cm, 512×512 pixels/frame, beam center=(256.13, 253.14), total frames=1151, oscillation/frame=0.500, exposure/frame=10.1 sec/frame, SAINT integration, hkl min/max=(−9, 9, −15, 15, −27, 27), data input to shelx=17025, unique data=3975, two-theta range=3.92 to 55.720, completeness to two-theta 55.72=99.80%, R(int-xl)=0.0681, SADABS correction applied.", "Structure was solved using XS(Shelxtl), refined using shelxtl software package, refinement by full-matrix least squares on F2, scattering factors from Int.", "Tab.", "Vol C Tables 4.2.6.8 and 6.1.1.4, number of data=3975, number of restraints=0, number of parameters=235, data/parameter ratio=16.91, goodness-of-fit on F2=1.04, R indices[I>4sigma(I)] R1=0.0505, wR2=0.1242, R indices (all data) R1=0.0769, wR2=0.1401, max difference peak and hole=0.724 and −0.277 e/Å3, refined flack parameter=−0.12(13), All of the CH hydrogen atoms were refined using a riding model.", "The OH hydrogens were found from a difference map and fully refined.", "Results showed that the asymmetric unit contains one molecule and one water as shown with thermal ellipsoids drawn to the 50% probability level.", "The stereochemistry at each of three stereocenters (as indicated in the name and structure of the compound above) was confirmed.", "The flack parameter refined to 0.28(24) indicating the correct enantiomeric setting.", "Example 21.", "((2S,5S)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile This compound was prepared according to the procedure described in Example 20, Step 2, using ((2S,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate (from Example 20, step 1, 2nd peak) instead of ((2R,5S)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate as starting material.", "LCMS calculated for C17H19N4O2S (M+H)+: m/z=343.1; Found: 343.0.Example 22.N-((1-((2S)-Bicyclo[2.2.1]heptan-2-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)methyl)methanesulfonamide Step 1.N-[(2S)-Bicyclo[2.2.1]hept-2-yl]-6-nitrothieno[3,2-b]pyridin-7-amine A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.064 g, 0.30 mmol) (Example 1, Step 2), bicyclo[2.2.1]heptan-2-amine (from Aldrich, 0.050 g, 0.45 mmol) and triethylamine (0.083 mL, 0.60 mmol) in isopropyl alcohol (1.4 mL) was heated at 90° C. for 2 h. The mixture was concentrated to give the desired product, which was used in the next step without further purification.", "LCMS calculated for C14H16N3O2S (M+H)+: m/z=290.1; Found: 290.0.Step 2.N7-[(2S)-Bicyclo[2.2.1]hept-2-yl]thieno[3,2-b]pyridine-6,7-diamine A mixture of N-[(2S)-bicyclo[2.2.1]hept-2-yl]-6-nitrothieno[3,2-b]pyridin-7-amine (0.080 g, 0.28 mmol) and 10% palladium on carbon (0.03 g) in methanol (3 mL) was subjected to balloon pressure of H2 at room temperature for 1 h. The mixture was filtered and the filtrate concentrated to give the desired product, which was used directly in the next step without further purification.", "LCMS calculated for C14H18N3S (M+H)+: m/z=260.1; Found: 260.0.Step 3.1-[(2S)-Bicyclo[2.2.1]hept-2-yl]-2-(chloromethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridine A mixture of N7-[(2S)-bicyclo[2.2.1]hept-2-yl]thieno[3,2-b]pyridine-6,7-diamine (0.060 g, 0.23 mmol) and 2-chloro-1,1,1-triethoxyethane (0.134 mL, 0.700 mmol) in acetic acid (0.2 mL) was stirred at 120° C. for 30 min.", "The solvent was removed and the resultant residue was dissolved in dichloromethane and purified on silica gel (eluting with 0-5% MeOH in dichloromethane) to give the desired product.", "LCMS calculated for C16H17ClN3S (M+H)+: m/z=318.1; Found: 318.0.Step 4.N-((1-((2S)-Bicyclo[2.2.1]heptan-2-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)methyl)methanesulfonamide To a solution of 1-[(2S)-bicyclo[2.2.1]hept-2-yl]-2-(chloromethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridine (0.10 g, 0.31 mmol) dissolved in N,N-dimethylformamide (1 mL) was added tert-butyl (methylsulfonyl)carbamate (0.092 g, 0.47 mmol) and potassium carbonate (0.087 g, 0.63 mmol).", "The mixture was stirred at 50° C. overnight, then diluted with water and extracted with EtOAc.", "The combined organic layers were dried over MgSO4 and concentrated to give crude tert-butyl ({1-[(2S)-bicyclo[2.2.1]hept-2-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl)(methylsulfonyl)carbamate.", "LCMS calculated for C22H29N4O4S2 (M+H)+: m/z=477.2; Found: 477.1.The crude intermediate was treated with trifluoroacetic acid (0.5 mL, 6 mmol) in methylene chloride (0.5 mL) at room temperature for 30 min, then the solvent was removed in vacuo.", "The residue was re-dissolved in MeOH and purified on prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (30 mg, 25%).", "LCMS calculated for C17H21N4O2S2 (M+H)+: m/z=377.1; Found: 377.0.Example 23.", "(trans-4-{7-[(1R)-1-Hydroxyethyl]-8H-pyrrolo[2,3-d]thieno[3,2-b]pyridin-8-yl}cyclohexyl)acetonitrile Step 1.6-Iodothieno[3,2-b]pyridin-7-ol A mixture of thieno[3,2-b]pyridin-7-ol (from Aldrich) (0.54 g, 3.6 mmol) and N-iodosuccinimide (0.88 g, 3.9 mmol) in acetonitrile (10 mL) was heated at reflux overnight.", "The mixture was concentrated under reduced pressure to give the desired product which was used in the next step without further purification.", "LCMS calculated for C7H5INOS (M+H)+: m/z=277.9; Found: 277.8.Step 2.7-Chloro-6-iodothieno[3,2-b]pyridine A mixture of the crude 6-iodothieno[3,2-b]pyridin-7-ol (0.99 g, 3.6 mmol) in phosphoryl chloride (20 mL) was heated at 120° C. for 2 h. The reaction was cooled to room temperature, concentrated under reduced pressure.", "The residue was co-evaporated with toluene, then diluted with dichloromethane and neutralized carefully with sat.", "NaHCO3 solution.", "The black tar was filtered off and the filtrate was transferred to a separation funnel.", "The organic layer was concentrated and purified on silica gel (eluting with 0-35% EtOAc/hexanes) to give the desired product (44% in 2 steps).", "LCMS calculated for C7H4ClINS (M+H)+: m/z=295.9; Found: 295.8.Step 3.", "(2R)-4-(7-Chlorothieno[3,2-b]pyridin-6-yl)but-3-yn-2-ol A mixture of 7-chloro-6-iodothieno[3,2-b]pyridine (0.46 g, 1.6 mmol), bis(triphenylphosphine)palladium(II) chloride (0.11 g, 0.16 mmol) and copper(I) iodide (30 mg, 0.16 mmol) was purged with N2.", "(2R)-but-3-yn-2-ol (0.13 g, 1.9 mmol) and triethylamine (4.5 mL, 33 mmol) was added via syringe.", "The reaction mixture was heated at reflux for 2 h. The mixture was concentrated under reduced pressure, and the resultant residue was purified on silica gel (eluting with 0-85% EtOAc/hexanes) to give the desired product.", "LCMS calculated for C11H9ClNOS (M+H)+: m/z=238.0; Found: 238.0.Step 4.", "(trans-4-{7-[(1R)-1-Hydroxyethyl]-8H-pyrrolo[2,3-d]thieno[3,2-b]pyridin-8-yl}cyclohexyl)acetonitrile A mixture of (2R)-4-(7-chlorothieno[3,2-b]pyridin-6-yl)but-3-yn-2-ol (0.055 g, 0.23 mmol), (trans-4-aminocyclohexyl)acetonitrile hydrochloride (0.040 g, 0.23 mmol), cesium carbonate (0.19 g, 0.58 mmol), palladium acetate (5.2 mg, 0.023 mmol) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (27 mg, 0.046 mmol) in toluene (1.1 mL) was purged with N2 for 3 times.", "The resulting mixture was stirred at 100° C. for 2 h, then at 120° C. for 2 h. The mixture was filtered.", "The filtrate was concentrated under reduced pressure, diluted with MeOH and purified on prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (1.4 mg, 1.8%).", "LCMS calculated for C19H22N3OS (M+H)+: m/z=340.1; Found: 340.1.Example 24.", "(1-Hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile Step 1.N-1,4-Dioxaspiro[4.5]dec-8-yl-6-nitrothieno[3,2-b]pyridin-7-amine A mixture of 1,4-dioxaspiro[4.5]decan-8-amine (from J&W PharmLab, 0.40 g, 2.5 mmol), 7-chloro-6-nitrothieno[3,2-b]pyridine (0.29 g, 1.4 mmol) and triethylamine (0.38 mL, 2.7 mmol) in isopropyl alcohol (4.4 mL) was stirred at 90° C. for 2 h. The mixture was concentrated to give the desired product to be used in the next step directly.", "LCMS calculated for C15H18N3O4S (M+H)+: m/z=336.1; Found: 336.0.Step 2.4-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanone A mixture of N-1,4-dioxaspiro[4.5]dec-8-yl-6-nitrothieno[3,2-b]pyridin-7-amine (0.45 g, 1.3 mmol) and 3.0 M hydrogen chloride in water (9 mL, 30 mmol) in acetone (20 mL) was stirred at room temperature for 20 min and then at 60° C. for 1 h. The mixture was basified with aq.", "5M NaOH solution at 0° C., then extracted with EtOAc.", "The combined organic layers were dried over sodium sulfate, concentrated and purified on silica gel column (eluting with 0-30% of EtOAc in methylene chloride) to give the desired product (0.2 g, 51% in 2 steps).", "LCMS calculated for C13H14N3O3S (M+H)+: m/z=292.1; Found: 292.0.Step 3.", "{1-Hydroxy-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile A solution of N,N-diisopropylamine (0.19 mL, 1.4 mmol) in tetrahydrofuran (3 mL) was cooled to 0° C. 1.6 M n-butyllithium in hexanes (0.86 mL, 1.4 mmol) was added dropwise, keeping the temperature below 5° C. After the addition was complete, the mixture was stirred for 20 min at 0° C. The mixture was then cooled to −78° C. and acetonitrile (0.072 mL, 1.4 mmol) was added, keeping the temperature below −70° C. After the addition was complete, the mixture was stirred for 20 min at −78° C. and a mixture of 4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanone (0.20 g, 0.69 mmol) in tetrahydrofuran (3 mL)/hexamethylphosphoramide (3 mL) was added, keeping the temperature below −70° C. After the addition was complete, the mixture was stirred for 30 min at −78° C. and then stirred at room temperature for 5 h. The mixture was partitioned between methylene chloride and sat.", "aq.", "NH4Cl solution.", "The organic phase was washed with water, dried over sodium sulfate, concentrated and purified on silica gel column (eluting with 0-30% EtOAc in methylene chloride) to give the desired product (0.11 g, 48%).", "LCMS calculated for C15H17N4O3S (M+H)+: m/z=333.1; Found: 333.0.Step 4.", "{4-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]-1-hydroxycyclohexyl}acetonitrile A mixture of {1-hydroxy-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (0.11 g, 0.33 mmol) and 10% Pd/C (0.050 g) in methanol (7 mL) was hydrogenated under balloon pressure of H2 at room temperature for 2 h. The mixture was filtered, concentrated and purified on silica gel column (eluting with 0-10% MeOH in methylene chloride) to give the desired product as a mixture of cis- and trans-isomer mixtures (38 mg, 38%).", "LCMS calculated for C15H19N4OS (M+H)+: m/z=303.1; Found: 303.0.Step 5.", "(trans-1-Hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile A mixture of (2R)-2-hydroxypropanamide (57 mg, 0.64 mmol) and triethyloxonium tetrafluoroborate (119 mg, 0.626 mmol) in tetrahydrofuran (0.8 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (0.23 mL) and added to a suspension of {4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-1-hydroxycyclohexyl}acetonitrile (38 mg, 0.12 mmol) in ethanol (0.84 mL).", "The mixture was stirred at 85° C. for 2 h and then purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give 2 peaks.", "On analytic HPLC (Waters SunFire C18, 2.1×50 mm, 5 μM; Flow rate 3 mL/min; Injection volume 2 μL; At gradient from 2 to 80% B in 3 minutes (A=water with 0.025% TFA, B=acetonitrile)): First peak (5 mg, 10%) retention time 0.952 min, LCMS calculated for C18H21N4O2S (M+H)+: m/z=357.1; Found: 357.1.1H NMR (DMSO-d6, 400 MHz) δ 8.94 (1H, s), 8.00 (1H, d, J=5.6 Hz), 7.60 (1H, d, J=5.6 Hz), 5.78 (1H, d, J=6.8 Hz), 5.22 (1H, s), 5.13 (1H, m), 4.82 (1H, m), 2.65 (4H, m), 1.86 (2H, m), 1.73-1.63 (4H, m), 1.59 (1H, d, J=6.8 Hz) ppm.", "Second peak (15 mg, 33%) retention time 0.977 min, LCMS calculated for C18H21N4O2S (M+H)+: m/z=357.1; Found: 357.1.H NMR (DMSO-d6, 400 MHz) δ 8.93 (1H, s), 7.99 (1H, d, J=5.6 Hz), 7.63 (1H, d, J=5.6 Hz), 5.82 (1H, d, J=6.8 Hz), 5.33 (1H, s), 5.15 (1H, m), 4.88 (1H, m), 3.05 (2H, m), 2.23 (2H, m), 1.93 (4H, m), 1.74 (2H, m), 1.61 (1H, d, J=6.8 Hz) ppm.", "Example 25.", "{(2E)-1-[trans-4-(Cyanomethyl)cyclohexyl]-1,3-dihydro-2H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-ylidene}cyanamide trifluoroacetate A solution of {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (0.028 g, 0.098 mmol), diphenyl cyanocarbonimidate (0.046 g, 0.20 mmol) and N,N-diisopropylethylamine (0.17 mL, 0.98 mmol) in acetonitrile (1 mL) was heated at 100° C. for 2 h. The mixture was stripped to dryness, diluted with methanol (MeOH) and then purified by prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 60 mL/min) to give the desired product as TFA salt (2.5 mg, 7.6%).", "LCMS calculated for C7H17N6S (M+H)+: m/z=337.1; Found: 337.1.Example 26.", "[trans-4-(2-Cyclopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile A mixture of cyclopropanecarboxamide (65.0 mg, 0.764 mmol) and triethyloxonium tetrafluoroborate (145 mg, 0.763 mmol) in tetrahydrofuran (0.4 mL) was stirred at room temperature for 1 h and then concentrated.", "A mixture of {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (22 mg, 0.077 mmol), and the above made reagent in ethanol (0.70 mL) was heated at reflux for 2 h. The mixture was purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (2.5 mg, 9.7%).", "LCMS calculated for C19H21N4S (M+H)+: m/z=337.1; Found: 337.0.Example 27.", "[trans-4-(2-Isopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile A mixture of 2-methylpropanamide (80 mg, 0.9 mmol) and triethyloxonium tetrafluoroborate (170 mg, 0.89 mmol) in tetrahydrofuran (0.4 mL) was stirred at room temperature for 1 h and then concentrated.", "A mixture of {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (22 mg, 0.077 mmol) and the above made reagent in ethanol (0.70 mL) was heated at reflux for 2 h. The mixture was purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (2.9 mg, 11%).", "LCMS calculated for C19H23N4S (M+H)+: m/z=339.2; Found: 339.0.Example 28.", "[trans-4-(2-Azetidin-3-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile Step 1.tert-Butyl 3-(aminocarbonyl)azetidine-1-carboxylate To a solution of 1-(tert-butoxycarbonyl)azetidine-3-carboxylic acid (from Activate Scientific.", "0.25 g, 1.2 mmol), ammonium acetate (0.14 g, 1.9 mmol) and N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (0.71 g, 1.9 mmol) in N,N-dimethylformamide (4 mL) was added N,N-diisopropylethylamine (0.43 mL, 2.5 mmol).", "The mixture was stirred at room temperature overnight.", "The mixture was diluted with MeOH and purified on prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (0.156 g, 63%).", "LCMS calculated for C9H6N2O3Na (M+Na)+: m/z=223.1; Found: 223.0.Step 2.tert-Butyl 3-{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}azetidine-1-carboxylate A mixture of tert-butyl 3-(aminocarbonyl)azetidine-1-carboxylate (156 mg, 0.779 mmol) and triethyloxonium tetrafluoroborate (280 mg, 1.5 mmol) in tetrahydrofuran (0.4 mL) was stirred at room temperature for 1 h and then concentrated.", "A mixture of {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (39 mg, 0.14 mmol) and the above made reagent in ethanol (0.70 mL) was heated at reflux for 2 h. The mixture was cooled to room temperature, diluted with EtOAc, washed with sat.", "NaHCO3 solution, dried over MgSO4, concentrated and purified on silica gel column (0-5% MeOH in methylene chloride) to give the desired product.", "LCMS calculated for C24H30N5O2S (M+H)+: m/z=452.2; Found: 452.1.Step 3.", "[trans-4-(2-Azetidin-3-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile 3-{1-[trans-4-(Cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}azetidine-1-carboxylate (14 mg, 0.031 mmol) was treated with trifluoroacetic acid (1 mL) in methylene chloride (1 mL) at room temperature for 1 h. The mixture was stripped to dryness, diluted with MeOH and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product.", "LCMS calculated for C19H22N5S (M+H)+: m/z=352.2; Found: 352.0.Example 29.", "{trans-4-[2-(1-Methylazetidin-3-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile To a solution of [trans-4-(2-azetidin-3-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile (14 mg, 0.038 mmol) in methanol (0.5 mL)/tetrahydrofuran (0.5 mL)/acetonitrile (0.5 mL) was added 37% aq.", "formaldehyde solution (12 μL, 0.16 mmol).", "The resulting mixture was stirred at room temperature for 10 min before sodium triacetoxyborohydride (16 mg, 0.077 mmol) was added.", "The mixture was stirred at room temperature for 1 h and then diluted with MeOH and purified by prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (0.8 mg, 6%).", "LCMS calculated for C20H24N5S (M+H)+: m/z=366.2; Found: 366.1.Example 30.3-[(cis-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)amino]propanenitrile Step 1.tert-Butyl {4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}carbamate A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (118 mg, 0.550 mmol), tert-butyl (4-aminocyclohexyl)carbamate (140 mg, 0.66 mmol) and triethylamine (0.23 mL, 1.6 mmol) in isopropyl alcohol (5 mL) was heated at 100° C. for 1 h. The mixture was concentrated to give the desired product as a mixture of cis- & trans-isomer mixtures to be used in the next step directly.", "LCMS calculated for C18H25N4O4S (M+H)+: m/z=393.2; Found: 393.1.Step 2.tert-Butyl {4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}carbamate tert-Butyl {4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}carbamate (216 mg, 0.550 mmol) and 10% Pd/C (20 mg) in methanol (5 mL) was subjected to balloon pressure of H2 at room temperature for 2 h. The mixture was filtered, concentrated and purified on silica gel column (eluting with 0-10% MeOH in methylene chloride) to give the desired product.", "LCMS calculated for C18H27N4O2S (M+H)+: m/z=363.2; Found: 363.1.Step 3.tert-Butyl (4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl) carbamate A mixture of (2R)-2-hydroxypropanamide (320 mg, 3.6 mmol) and triethyloxonium tetrafluoroborate (0.69 g, 3.6 mmol) in tetrahydrofuran (3 mL) was stirred at room temperature for 1 h and then concentrated.", "A mixture of tert-butyl {4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}carbamate (191 mg, 0.527 mmol) and the above made reagent in ethanol (4.8 mL) was heated at reflux for 2 h. The mixture was concentrated and purified on silica gel column (eluting with 0-10% MeOH in methylene chloride) to give the desired product.", "LCMS calculated for C21H29N4O3S (M+H)+: m/z=417.2; Found: 417.0.Step 4.", "(1R)-1-[1-(4-Aminocyclohexyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl]ethanol dihydrochloride tert-Butyl (4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)carbamate (0.22 g, 0.53 mmol) was treated with 4.0 M hydrogen chloride in dioxane (0.66 mL, 2.6 mmol) in methylene chloride (3 mL) at room temperature overnight.", "The mixture was concentrated to give the desired product as HCl salt (0.22 g, 94%).", "LCMS calculated for C16H21N4OS (M+H)+: m/z=317.1; Found: 317.0.Step 5.3-[(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)amino]propanenitrile To a solution of (1R)-1-[1-(4-aminocyclohexyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl]ethanol dihydrochloride (26 mg, 0.067 mmol) in acetonitrile (0.45 mL) was added 1,8-diazabicyclo[5.4.0]undec-7-ene (50 μL, 0.33 mmol) followed by 2-propenenitrile (8.78 μL, 0.134 mmol).", "The resulting mixture was stirred at room temperature overnight.", "After evaporated to dry, the residue was purified by prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give 2 peaks.", "On analytic HPLC (Waters SunFire C18, 2.1×50 mm, 5 μM; Flow rate 3 mL/min; Injection volume 2 μL; At gradient from 2 to 80% B in 3 minutes (A=water with 0.025% TFA, B=acetonitrile)): First peak (4.3 mg, 17%) retention time 0.683 min, LCMS calculated for C19H24N5OS (M+H)+: m/z=370.2; Found: 370.1.Second peak from the prep-HPLC (4.3 mg, 17%) retention time is 0.598 min on the analytic HPLC, LCMS calculated for C19H24N5OS (M+H)+: m/z=370.2; Found: 370.1.Example 31.N-Ethyl-2-(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetamide Step 1.Ethyl {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetate A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (97 mg, 0.45 mmol), ethyl (trans-4-aminocyclohexyl)acetate hydrochloride (from Activate Scientific, 120 mg, 0.54 mmol) and triethylamine (0.19 mL, 1.4 mmol) in isopropyl alcohol (4 mL) was heated at 100° C. for 1 h. The mixture was concentrated to give the desired product to be used in the next step directly.", "LCMS calculated for C17H22N3O4S (M+H)+: m/z=364.1; Found: 364.1.Step 2.Ethyl {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetate Ethyl {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetate (160 mg, 0.44 mmol) and 10% Pd/C (20 mg) in methanol (4 mL) was subjected to balloon pressure of H2 at room temperature for 2 h. The mixture was filtered.", "The filtrate was concentrated and purified on silica gel column (eluting with 0-10% MeOH in methylene chloride) to give the desired product.", "LCMS calculated for C17H24N3O2S (M+H)+: m/z=334.2; Found: 334.1.Step 3.Ethyl (trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetate A mixture of (2R)-2-hydroxypropanamide (170 mg, 1.9 mmol) and triethyloxonium tetrafluoroborate (0.36 g, 1.9 mmol) in tetrahydrofuran (2 mL) was stirred at room temperature for 1 h and then concentrated.", "A mixture of ethyl {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetate (150 mg, 0.45 mmol) and the above made reagent in ethanol (4.8 mL) was heated at reflux for 2 h. The mixture was concentrated and purified on silica gel column (eluting with 0-5% MeOH in methylene chloride) to give the desired product (0.15 g, 86%).", "LCMS calculated for C20H26N3O3S (M+H)+: m/z=388.2; Found: 388.1.Step 4.", "(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetic acid A mixture of ethyl (trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetate (0.15 g, 0.39 mmol) and lithium hydroxide, monohydrate (0.079 g, 1.9 mmol) in water (0.7 mL)/methanol (1.7 mL)/tetrahydrofuran (1.7 mL) was stirred at room temperature overnight.", "The reaction was acidified with 1N aq.", "HCl solution to pH=4, extracted with methylene chloride.", "The combined organic layers were dried over MgSO4 and concentrated to give the desired product (0.11 g, 79%) to be used in the next step directly.", "LCMS calculated for C18H22N3O3S (M+H)+: m/z=360.1; Found: 360.1.Step 5.N-Ethyl-2-(trans-4-{2-[(R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetamide To a solution of (trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetic acid (11 mg, 0.031 mmol), 2.0 M ethylamine in THF (23 μL, 0.046 mmol) and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (23 mg, 0.052 mmol) in N,N-dimethylformamide (0.4 mL) was added N,N-diisopropylethylamine (0.016 mL, 0.092 mmol).", "The mixture was stirred at room temperature for 2 h. The mixture was diluted with MeOH and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (1.8 mg, 15%).", "LCMS calculated for C20H27N4O2S (M+H)+: m/z=387.2; Found: 387.1.Example 32.3-(3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)propanenitrile Step 1.tert-Butyl [3-(hydroxymethyl)cyclohexyl]carbamate To a mixture of 3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylic acid (from Alfa Aesar, 3.3 g, 14 mmol) and triethylamine (3.8 mL, 27 mmol) in tetrahydrofuran (40 mL) at 0° C. was added dropwise ethyl chloroformate (1.9 mL, 20 mmol).", "The mixture was stirred at 0° C. for 10 min and then at room temperature for 20 min.", "The mixture was filtered to remove the white solid and then cooled to 0° C. A mixture of sodium tetrahydroborate (1.0 g, 27 mmol) and methanol (1 mL) was added slowly.", "The mixture was stirred at room temperature for 1 h. The mixture was quenched with 1N aq.", "HCl solution and extracted with EtOAc.", "The extracts were concentrated and purified on silica gel column (eluting with 75% EtOAc in hexanes) to give the desired product (2.88 g, 92%).", "LCMS calculated for C13H23NO3Na (M+Na)+: m/z=252.2; Found: 252.1.Step 2.tert-Butyl (3-formylcyclohexyl)carbamate To a solution of tert-butyl [3-(hydroxymethyl)cyclohexyl]carbamate (0.51 g, 2.2 mmol) in methylene chloride (10 mL) at 0° C. was added Dess-Martin periodinane (1.1 g, 2.7 mmol).", "The mixture was stirred at room temperature for 2 h. The reaction was quenched with aq.", "1N NaOH solution and extracted with methylene chloride.", "The combined organic layers were washed with water and then brine, dried over MgSO4, concentrated, and then purified on silica gel column (eluting with 20-50% EtOAc in hexanes) to give the desired product (0.3 g, 59%).", "LCMS calculated for C12H21NO3Na (M+Na)+: m/z=250.2; Found: 250.1.Step 3.tert-Butyl {3-[2-cyanovinyl]cyclohexyl}carbamate To 1.0 M potassium tert-butoxide in THF (2.0 mL, 2.0 mmol) was added diethyl cyanomethylphosphonate (0.30 mL, 1.8 mmol) dropwise at 0° C. and the mixture was stirred at 0° C. for 1 h. A solution of tert-butyl (3-formylcyclohexyl)carbamate (0.30 g, 1.3 mmol) in tetrahydrofuran (9.3 mL) was added dropwise, then cooling bath was removed, and the mixture was stirred at room temperature overnight.", "The mixture was diluted with EtOAc, washed with water, concentrated and purified on silica gel column (eluting with 0-30% EtOAc in hexanes) to give the desired product as a mixture of cis- and trans-isomer mixtures (0.12 g, 36%).", "LCMS calculated for C14H22N2O2Na (M+Na)+: m/z=273.2; Found: 273.1.Step 4.3-(3-Aminocyclohexyl)acrylonitrile hydrochloride tert-Butyl {3-[2-cyanovinyl]cyclohexyl}carbamate was treated with 4.0 M hydrogen chloride in dioxane (1.6 mL, 6.6 mmol) in methylene chloride (2 mL) at room temperature for 2 h. The mixture was stripped to dryness to give the desired product as a mixture of cis- and trans-isomers.", "LCMS calculated for C9H15N2 (M+H)+: m/z=151.1; Found: 151.1.Step 5.3-{3-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile A mixture of 3-(3-aminocyclohexyl)acrylonitrile hydrochloride (0.090 g, 0.48 mmol), 7-chloro-6-nitrothieno[3,2-b]pyridine (0.085 g, 0.40 mmol) and triethylamine (0.22 mL, 1.6 mmol) in isopropyl alcohol (0.9 mL) was heated at 90° C. for 1 h. The mixture was concentrated to give the desired product to be used in the next step directly.", "LCMS calculated for C16H17N4O2 (M+H)+: m/z=329.1; Found: 329.1.Step 6.3-{3-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}propanenitrile A mixture of 3-{3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile (0.13 g, 0.40 mmol) and 10% Pd/C (0.05 g) in methanol (10 mL) was hydrogenated under balloon pressure of H2 at room temperature over weekend.", "The mixture was filtered, concentrated and purified on silica gel column (eluting with 0-10% MeOH in methylene chloride) to give the desired product.", "LCMS calculated for C16H21N4S (M+H)+: m/z=301.1; Found: 301.0.Step 7.3-(3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)propanenitrile A mixture of (2R)-2-hydroxypropanamide (194 mg, 2.18 mmol) and triethyloxonium tetrafluoroborate (0.41 g, 2.2 mmol) in tetrahydrofuran (2 mL) was stirred at room temperature for 1 h and then concentrated.", "A mixture of 3-{3-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}propanenitrile (131 mg, 0.436 mmol) and the above made reagent in ethanol (4.7 mL) was heated at reflux for 2 h. The mixture was filtered, diluted with MeOH and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (60 mg, 39%).", "LCMS calculated for C19H23N4OS (M+H)+: m/z=355.2; Found: 355.0.Example 33.", "[4-(7-Methylimidazo[1,2-a]thieno[3,2-a]pyrazin-8-yl)phenyl]acetonitrile Step 1.6-Bromo-5-chloro-2-methylimidazo[1,2-a]pyrazine Into a 1-neck round-bottom flask N,N-diisopropylamine (0.50 mL, 3.6 mmol) was dissolved in tetrahydrofuran (4.0 mL) and cooled at −78° C. 1.6 M n-butyllithium in hexane (1.9 mL, 3.1 mmol) was added.", "The reaction was stirred at −78° C. for 30 min and 6-bromo-2-methylimidazo[1,2-a]pyrazine (from Ark Pharm, 0.500 g, 2.36 mmol) in tetrahydrofuran (6.0 mL) was added dropwise.", "The reaction mixture was stirred at −78° C. for 45 min and hexachloroethane (0.72 g, 3.1 mmol) was added.", "The resulting mixture was stirred at −78° C. for 1 h. The reaction was quenched with NH4Cl solution and then partitioned between EtOAc and water.", "The EtOAc extract was washed with brine, dried (MgSO4), and stripped in vacuo.", "The residue was chromatographed on silica gel eluting with 40% EtOAc in hexanes to give the desired product (0.25 g, 43%).", "LCMS calculated for C7H6BrClN3 (M+H)+: m/z=245.9; Found: 245.9.1H NMR (CDCl3, 400 MHz) δ 8.72 (1H, s), 7.68 (1H, s), 2.56 (3H, s) ppm.", "Step 2.5-Chloro-2-methyl-6-[(trimethylsilyl)ethynyl]imidazo[1,2-a]pyrazine A mixture of 6-bromo-5-chloro-2-methylimidazo[1,2-a]pyrazine (0.710 g, 2.88 mmol), bis(triphenylphosphine)palladium(II) chloride (0.1 g, 0.1 mmol), (trimethylsilyl)acetylene (0.90 mL, 6.3 mmol), copper(I) iodide (0.04 g, 0.2 mmol), and triethylamine (0.803 mL, 5.76 mmol) in N,N-dimethylformamide (8.5 mL) was heated in an oil bath at 45° C. and stirring for 14 h. The reaction was quenched with water (20 ml) and was extracted with ethyl acetate (2×100 ml).", "The combined organic extracts were washed with water (10 ml), saturated NaCl (10 ml), dried over Na2SO4 and the solvent removed in vacuo.", "The product was purified by silica gel chromatography eluting with 10-20% EtOAc in hexanes to give the desired product (0.39 g, 76%).", "LCMS calculated for C12H15ClN3Si (M+H)+: m/z=264.1; Found: 264.0.Step 3.7-Methylimidazo[1,2-a]thieno[3,2-e]pyrazine A mixture of 5-chloro-2-methyl-6-[(trimethylsilyl)ethynyl]imidazo[1,2-a]pyrazine (0.400 g, 1.52 mmol), and sodium sulfide nonahydrate (1.09 g, 4.55 mmol) in N,N-dimethylformamide (6.0 mL) was heated in a preheated oil bath at 100° C. with stirring for 1 h. The reaction was cooled and partitioned between EtOAc and water.", "The organic layer was washed with water, brine, dried and the solvent was removed in vacuo.", "The residue was chromatographed on silica gel eluting with EtOAc and 3% MeOH in EtOAc to give the desired product (0.15 g, 52%).", "LCMS calculated for C9H8N3S (M+H)+: m/z=190.0; Found: 190.0.Step 4.8-Iodo-7-methylimidazo[1,2-a]thieno[3,2-e]pyrazine A mixture of 7-methylimidazo[1,2-a]thieno[3,2-e]pyrazine (30 mg, 0.16 mmol), and N-iodosuccinimide (39 mg, 0.17 mmol) in methylene chloride (1.2 mL) was stirred at 25° C. for 16 h. The product was purified by prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (15 mg, 30%).", "LCMS calculated for C9H7IN3S (M+H)+: m/z=315.9; Found: 316.0.1H NMR (CDCl3, 400 MHz) δ 8.89 (1H, s), 7.55 (1H, d, J=5.6 Hz), 7.35 (1H, d, J=5.6 Hz), 2.55 (3H, s) ppm.", "Step 5.", "[4-(7-Methylimidazo[1,2-a]thieno[3,2-e]pyrazin-8-yl)phenyl]acetonitrile A mixture of [4-(cyanomethyl)phenyl]boronic acid (from Aldrich, 9.3 mg, 0.058 mmol), 8-iodo-7-methylimidazo[1,2-a]thieno[3,2-e]pyrazine (12 mg, 0.038 mmol), and potassium carbonate (16 mg, 0.12 mmol), in acetonitrile (0.6 mL) and water (0.2 mL) was degassed.", "Into the mixture was added tetrakis(triphenylphosphine)palladium(0) (2.2 mg, 0.0019 mmol).", "The reaction mixture was heated at 160° C. for 10 min in a microwave reactor.", "The reaction was diluted with methanol, filtered.", "The filtrate was purified by prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product.", "LCMS calculated for C17H13N4S (M+H)+: m/z=305.1; Found: 305.0.1H NMR (CDCl3, 400 MHz) δ 9.01 (1H, s), 7.55 (4H, m), 7.49 (1H, d, J=6.0 Hz), 7.14 (1H, d, J=6.0 Hz), 3.93 (2H, s), 2.48 (3H, s) ppm.", "Example 34.Mixture of [(1R, 2R, 4S)-2-hydroxy-4-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile trifluoroacetate and [(1S, 2S, 4R)-2-hydroxy-4-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile trifluoroacetate Step 1.Methyl-2-methoxy-4-[(trimethylsilyl)oxy]cyclohex-3-ene-1-carboxylate A mixture of methyl acrylate (5.23 mL, 58.0 mmol) and 1-methoxy-3-(trimethylsiloxy)-1,3-butadiene (from Aldrich, 10.0 g, 58.0 mmol) in toluene (100 mL) was heated at 80° C. for 2 d. The reaction solution was concentrated and purified on silica gel column to give the desired product as a mixture of trans- and cis-isomers (8.3 g, 55%).", "H NMR (500 MHz, CDCl3) δ 5.16 (1H, m), 4.97 (1H, m), 4.22 (1H, m), 4.08 (1H, m), 3.68 (3H, s), 3.67 (3H, s), 3.32 (3H, s), 3.24 (3H, s), 2.59 (1H, m), 2.51 (1H, m), 1.80-2.14 (8H, m), 0.18 (18H, s) ppm.", "Step 2.Methyl (1S, 2R)-2-methoxy-4-oxocyclohexanecarboxylate (racemic) and methyl (1S, 2S)-2-methoxy-4-oxocyclohexanecarboxylate (racemic) To a solution of methyl-2-methoxy-4-[(trimethylsilyl)oxy]cyclohex-3-ene-1-carboxylate (8.3 g, 32 mmol) in methanol (200 mL) was added potassium carbonate (2.2 g, 16 mmol) at 0° C. After stirring for 20 min, the reaction was diluted with saturated NH4Cl solution and ethyl acetate.", "The aqueous layer was extracted with ethyl acetate.", "The combined organic layers were washed with brine, dried over Na2SO4, concentrated in vacuo.", "The crude was purified with flash chromatography (eluting with 0 to 50% ethyl acetate in hexanes) to give trans-isomer (first elute, 1.5 g, 25%), and cis-isomer (last elute, 1.35 g, 22%).", "For the trans-isomer: 1H NMR (400 MHz, CDCl3) δ 3.89 (1H, m), 3.75 (3H, s), 3.33 (3H, s), 2.85 (1H, m), 2.78 (1H, m), 2.44 (2H, m), 2.32 (1H, m), 2.15 (1H, m), 1.96 (1H, m) ppm.", "For the cis-isomer: 1H NMR (400 MHz, CDCl3) δ 4.18 (1H, m), 3.72 (3H, s), 3.30 (3H, s), 2.85 (2H, m), 2.46 (2H, m), 2.28 (1H, m), 2.12 (1H, m) ppm.", "Step 3.Methyl (1S, 2R, 4R)-4-hydroxy-2-methoxycyclohexanecarboxylate (racemic) To a solution of methyl (1S,2R)-2-methoxy-4-oxocyclohexanecarboxylate (racemic, cis-isomer from last step) (1.35 g, 7.25 mmol) in methanol (30 mL) was added sodium tetrahydroborate (270 mg, 7.2 mmol) at −78° C. After stirring for 1 h, the reaction was diluted with sat.", "NH4Cl solution and ethyl acetate.", "The aqueous layer was extracted with ethyl acetate.", "The combined organic layers were washed with brine, dried over Na2SO4, concentrated and purified with flash chromatography (eluting with 70% ethyl acetate in hexanes) to give the desired product (1.26 g, 92%).", "1H NMR (500 MHz, CDCl3) δ 3.96 (2H, m), 3.72 (3H, s), 3.38 (3H, s), 2.45 (1H, m), 2.31 (1H, m), 2.11 (1H, m), 1.97 (1H, m), 1.77 (1H, m), 1.50 (2H, m) ppm.", "Step 4.Methyl (1S, 2R, 4R)-2-methoxy-4-[(methylsulfonyl)oxy]cyclohexanecarboxylate (racemic) A solution of methyl (1S, 2R, 4R)-4-hydroxy-2-methoxycyclohexanecarboxylate (racemic) (1.14 g, 6.06 mmol) in dichloromethane (30 mL) was treated with methanesulfonyl chloride (0.938 mL, 12.1 mmol) dropwise at 0° C. The mixture was stirred at 0° C. for 2 h and partitioned between ethyl acetate and water.", "The organic phase was concentrated and purified on silica gel (eluting with 50% ethyl acetate in hexanes) to give the desired product (1.48 g, 93%).", "1H NMR (400 MHz, CDCl3) δ 4.89 (1H, m), 3.70 (3H, s), 3.62 (1H, m), 3.36 (3H, s), 3.02 (3H, s), 2.78 (1H, m), 2.42 (1H, m), 2.01 (2H, m), 1.98 (1H, m), 1.80 (1H, m), 1.62 (1H, m) ppm.", "Step 5.Methyl (1S,2R,4S)-4-azido-2-methoxycyclohexanecarboxylate (racemic) To a solution of methyl (1S,2R,4R)-2-methoxy-4-[(methylsulfonyl)oxy]cyclohexanecarboxylate (racemic) (1.48 g, 5.56 mmol) in DMF (19 mL) sodium azide (1.4 g, 22 mmol) was added.", "The reaction mixture was stirred and heated at 80° C. for 4 h. The reaction mixture was poured into sat.", "NaHCO3 solution and extracted with ethyl acetate (2×30 mL).", "The combined extracts were washed with brine, dried over Na2SO4, concentrated.", "The crude was purified by flash chromatography (eluting with a gradient of 0-35% ethyl acetate in hexanes) to give the desired product as colorless oil (1.02 g, 86%).", "1H NMR (300 MHz, CDCl3) δ 3.98 (1H, m), 3.76 (3H, s), 3.58 (1H, m), 3.36 (3H, s), 2.38 (2H, m), 2.06 (1H, m), 1.90 (2H, m), 1.36 (2H, m) ppm.", "Step 6.Methyl (1S,2R,4S)-4-[(tert-butoxycarbonyl)amino]-2-methoxycyclohexanecarboxylate (racemic) To a solution of methyl (1S,2R,4S)-4-azido-2-methoxycyclohexanecarboxylate (racemic) (901 mg, 4.22 mmol) in methanol (26 mL) was added di-tert-butyldicarbonate (1.11 g, 5.07 mmol) followed by 10% palladium on carbon (720 mg, 0.68 mmol).", "The resulting mixture was stirred under balloon pressure of hydrogen overnight.", "The reaction mixture was filtered through a pad of Celite and washed with methanol.", "The solvent was removed and residue was purified with flash chromatography (eluting with 0-40% ethyl acetate in hexanes) to give the desired product as colorless oil (0.96 g, 79%).", "1H NMR (300 MHz, CDCl3) δ 4.38 (1H, m), 3.92 (1H, m), 3.66 (3H, s), 3.28 (3H, s), 2.35 (2H, m), 2.07-1.76 (3H, m), 1.40 (9H, s), 1.08 (2H, m) ppm.", "Step 7.tert-Butyl [(1S,3R,4R)-4-(hydroxymethyl)-3-methoxycyclohexyl]carbamate (racemic) Methyl (1S,2R,4S)-4-[(tert-butoxycarbonyl)amino]-2-methoxycyclohexanecarboxylate (racemic) (0.87 g, 3.0 mmol) were dissolved in ether (27 mL) and cooled to 0° C. Lithium tetrahydroaluminate (138 mg, 3.63 mmol) was added and the resulting reaction mixture was stirred for 4 h. The reaction was quenched with 5 mL water at 0° C., then diluted with 5 mL 15% NaOH and 15 mL water after stirring for 30 min.", "The reaction mixture was filtered through a pad of Celite and washed with ethyl acetate.", "The aqueous layer was extracted with ethyl acetate (2×).", "The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated.", "The crude was purified with flash chromatography (eluting with a gradient of 0-80% ethyl acetate in hexanes) to give the desired product as white foam.", "Step 8.", "{(1R,2R,4S)-4-[(tert-Butoxycarbonyl)amino]-2-methoxycyclohexyl}methyl methanesulfonate (racemic) To a solution of tert-butyl [(1S,3R,4R)-4-(hydroxymethyl)-3-methoxycyclohexyl]carbamate (racemic) (671 mg, 2.59 mmol) in dichloromethane (8 mL) was added methanesulfonyl chloride (0.401 mL, 5.18 mmol) at 0° C. The mixture was stirred at 0° C. for 1 h, then concentrated and partitioned between ethyl acetate and water.", "The organic phase was concentrated and purified by flash chromatography (eluting with a gradient of 50% ethyl acetate in hexanes) to give the desired product (0.87 g, 100%).", "LCMS calculated for C9H16NO5S (M+H-t-Bu-MeOH)+: m/z=250.1; Found: 250.0.Step 9.", "[(1R,2R,4S)-4-Amino-2-methoxycyclohexyl]acetonitrile trifluoroacetate (racemic) A mixture of {(1R,2R,4S)-4-[(tert-butoxycarbonyl)amino]-2-methoxycyclohexyl}methyl methanesulfonate (racemic) (703 mg, 2.08 mmol) and sodium cyanide (120 mg, 2.5 mmol) in DMSO (7 mL) was stirred at 90° C. overnight.", "After cooling, the mixture was partitioned between ethyl acetate and brine.", "The organic layer was washed with water and brine, and concentrated to give the Boc-protected azide intermediate.", "A solution of the intermediate in dichloromethane (9 mL) was treated with TFA (9 mL) and stirred at room temperature for 2 h. The reaction solution was concentrated to give the desired product as TFA salt.", "LCMS calculated for C9H17N2O (M+H)+: m/z=169.1; Found: 169.2.Step 10.", "{(1R,2R,4S)-2-Methoxy-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (racemic) A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (381 mg, 1.78 mmol), [(1R,2R,4S)-4-amino-2-methoxycyclohexyl]acetonitrile (racemic) (310 mg, 1.8 mmol) and N,N-diisopropylethylamine (1.2 mL, 7.1 mmol) in isopropyl alcohol (4.2 mL) was heated at 90° C. for 2 h. The crude was concentrated and purified with flash chromatography to give the desired product (485 mg, 78%).", "LCMS calculated for C15H19N4O3S (M+H)+: m/z=347.1; Found: 347.0.Step 11.", "{(1R,2R,4S)-4-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]-2-methoxycyclohexyl}acetonitrile (racemic) A mixture of {(1R,2R,4S)-2-methoxy-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (racemic) (380 mg, 1.1 mmol) and 10% palladium on carbon (0.38 g, 0.36 mmol) in methanol (7.3 mL) was subjected to balloon pressure of H2 at room temperature for 2 h. The mixture was filtered and the filtrate was concentrated and purified with flash chromatography (eluting with 15% methanol in dichloromethane) to give the desired product (310 mg, 89%).", "LCMS calculated for C16H21N4OS (M+H)+: m/z=317.1; Found: 317.1.Step 12.", "[(1R,2R,4S)-2-Methoxy-4-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile (racemic) A mixture of {(1R,2R,4S)-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-2-methoxycyclohexyl}acetonitrile (racemic) (45 mg, 0.14 mmol) and triethyl orthoacetate (79 μL, 0.43 mmol) in acetic acid (0.4 mL, 7 mmol) was stirred at 120° C. for 30 min.", "The solvent was removed, and the residue dissolved in methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (28 mg, 58%).", "LCMS calculated for C18H21N4OS (M+H)+: m/z=341.1; Found: 341.0.Step 13.Mixture of [(1R, 2R, 4S)-2-hydroxy-4-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile trifluoroacetate and [(1S, 2S, 4R)-2-hydroxy-4-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile trifluoroacetate To a microwave vial charged with [(1R,2R,4S)-2-methoxy-4-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile (racemic) (28 mg, 0.082 mmol) was added acetonitrile (1 mL) and iodotrimethylsilane (0.60 mL, 4.2 mmol).", "The reaction solution was heated at 80° C. for 6 h. The reaction mixture was diluted with methanol and purified with HPLC purification (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% TFA, at flow rate of 60 mL/min) to give the desired product as a racemic mixture.", "LCMS calculated for C17H19N4OS (M+H)+: m/z=327.1; Found: 327.1.Example 35.Mixture of [(1R,2R,4S)-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-methoxycyclohexyl]acetonitrile trifluoroacetate and [(1S,2S,4R)-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-methoxycyclohexyl]acetonitrile trifluoracetate Step 1.", "[(1R,2S,4S)-4-(2-Ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-methoxycyclohexyl]acetonitrile (racemic) The desired compound was prepared according to the procedure of Example 34, steps 12, using 1,1,1-triethoxy-{(1R,2R,4S)-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-2-methoxycyclohexyl}acetonitrile (racemic) and propane as the starting material.", "LCMS calculated for C19H23N4OS (M+H)+: m/z=355.2; Found: 355.1.Step 2.Mixture of [(1R,2R,4S)-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-methoxycyclohexyl]acetonitrile trifluoroacetate and [(1S,2S,4R)-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-methoxycyclohexyl]acetonitrile trifluoracetate The desired compound was prepared according to the procedure of Example 34, steps 13, using [(1R,2S,4S)-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-methoxycyclohexyl]acetonitrile (racemic) as the starting material.", "LCMS calculated for C18H21N4OS (M+H)+: m/z=341.1; Found: 341.1.Example 36.", "((1R,2R,4S)-2-Hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile and ((1S,2S,4R)-2-hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile Step 1.Mixture of ((1R,2R,4S)-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}-2-methoxycyclohexyl)acetonitrile and ((1R,2R,4S)-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}-2-methoxycyclohexyl)acetonitrile A mixture of (2R)-2-hydroxypropanamide (82.2 mg, 0.922 mmol) and triethyloxonium tetrafluoroborate (160 mg, 0.87 mmol) in THF (4.6 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (2.0 mL) and added to a suspension of {(1R,2R,4S)-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-2-methoxycyclohexyl}acetonitrile (racemic) (89 mg, 0.28 mmol) in ethanol (0.9 mL).", "The mixture was stirred at 80° C. for 1 h. The reaction mixture was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product as white solid (65 mg, 62%).", "LCMS calculated for C19H23N4O2S (M+H)+: m/z=371.2; Found: 371.0.Step 2.", "((1R,2R,4S)-2-Hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile and ((1S,2S,4R)-2-hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile To a solution of ((1R,2R,4S)-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}-2-methoxycyclohexyl)acetonitrile (diastereoisomer mixture) (40.2 mg, 0.108 mmol) in acetonitrile (2.5 mL) was added iodotrimethylsilane (772 μL, 5.42 mmol).", "The resulting mixture was heated at 90° C. for 4 h. The reaction was quenched with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% TFA, at flow rate of 60 mL/min) to give the desired product as mixture of two diastereomers.", "The racemic mixture was separated by chiral column (Phenomenex Lux Cellulose A-2, 5 um, 21.2×250 mm, 15% ethanol/85% hexanes, flow rate: 18 ml/min, 2 mg/injection) to give two peaks.", "Isomer 1 (first to elute): LCMS calculated for C18H21N4O2S (M+H)+: m/z=357.1; Found: 357.0.Isomer 2 (second to elute): LCMS calculated for C18H21N4O2S (M+H)+: m/z=357.1; Found: 357.0.Example 37.", "((1R,2S,4S)-2-Hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile trifluoacetate and ((1S,2R,4R)-2-hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile trifluoacetate Step 1.Methyl (1S,2S,4R)-4-hydroxy-2-methoxycyclohexanecarboxylate (racemic) To a solution of methyl (1S,2S)-2-methoxy-4-oxocyclohexanecarboxylate (trans-isomer from example 34 step 2, first elute, racemic) (1.5 g, 8.0 mmol) in THF (20 mL) at −78° C. was added 1.0 M L-Selectride in THF (12 mL).", "After stirring at the same temperature for 2 h, the reaction was diluted with sat.", "NaHCO3 solution and ethyl acetate.", "The aqueous layer was extracted with ethyl acetate (3×).", "The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated.", "The crude was purified with flash chromatography (eluting with 0-65% ethyl acetate in hexanes) to give the desired product as colorless oil (1.5 g, 100%).", "1H NMR (400 MHz, CDCl3) δ 4.18 (1H, m), 3.82 (1H, m), 3.70 (3H, s), 3.32 (3H, s), 2.43 (1H, m), 2.10 (1H, m), 1.96 (1H, m), 1.76 (1H, m), 1.71-1.48 (2H, m), 1.40 (1H, m) ppm.", "Step 2.Methyl (1R,2R,4S)-2-methoxy-4-[(methylsulfonyl)oxy]cyclohexanecarboxylate (racemic) A solution of methyl (1R,2R,4S)-4-hydroxy-2-methoxycyclohexanecarboxylate (racemic) (1.50 g, 7.97 mmol) in dichloromethane (40 mL) was treated with methanesulfonyl chloride (1.23 mL, 15.9 mmol) dropwise at 0° C. The mixture was stirred at 0° C. for 2 h and partitioned between ethyl acetate and water.", "The organic phase was concentrated and purified on silica gel (eluting with 50% ethyl acetate in hexanes) to give the desired product (2.12 g, 91%).", "1H NMR (400 MHz, CDCl3) δ 4.62 (1H, m), 3.71 (3H, s), 3.48 (1H, m), 3.33 (3H, s), 3.02 (3H, s), 2.64 (1H, m), 2.32 (1H, m), 2.19 (1H, m), 2.00 (1H, m), 1.60-1.42 (3H, m) ppm.", "Step 3.Methyl (1R,2R,4R)-4-azido-2-methoxycyclohexanecarboxylate (racemic) To a solution of methyl (1R,2R,4S)-2-methoxy-4-[(methylsulfonyl)oxy]cyclohexanecarboxylate (racemic) (1.92 g, 7.21 mmol) in DMF (24 mL) sodium azide (1.9 g, 29 mmol) was added.", "The reaction mixture was stirred and heated at 80° C. for 4 h. The reaction mixture was poured into sat.", "NaHCO3 solution and extracted with ethyl acetate (2×30 mL).", "The combined extracts were washed with brine, dried over Na2SO4, concentrated.", "The crude was purified by flash chromatography (eluting with a gradient 0-35% ethyl acetate in hexanes) to give the desired product as colorless oil (1.22 g, 79%).", "1H NMR (500 MHz, CDCl3) δ 3.70 (3H, s), 3.44 (1H, m), 3.32 (3H, s), 3.30 (1H, m), 2.48 (1H, m), 2.32 (1H, m), 2.00 (2H, m), 1.48 (1H, m), 1.28 (2H, m) ppm.", "Step 4.Methyl (1S,2S,4S)-4-[(tert-butoxycarbonyl)amino]-2-methoxycyclohexanecarboxylate (racemic) A solution of methyl (1S,2S,4S)-4-azido-2-methoxycyclohexanecarboxylate (racemic) (1.2 g, 5.6 mmol) in methanol (34 mL) was added di-tert-butyldicarbonate (1.47 g, 6.75 mmol), followed by 10% palladium on carbon (960 mg).", "The resulting mixture was stirred under H2 balloon overnight.", "The reaction mixture was filtered through a pad of Celite and washed with methanol.", "The solvent was removed and residue was purified with flash chromatography (eluting with a gradient 0-40% ethyl acetate in hexanes) to give the desired product as colorless oil (1.02 g, 63%).", "1H NMR (400 MHz, CDCl3) δ 4.54 (1H, m), 3.68 (3H, s), 3.48 (1H, m), 3.32 (3H, s), 2.43 (1H, m), 2.31 (1H, m), 1.94 (2H, m), 1.54 (1H, m), 1.43 (9H, s), 1.08 (2H, m) ppm.", "Step 5.tert-Butyl [(1S,3S,4R)-4-(hydroxymethyl)-3-methoxycyclohexyl]carbamate (racemic) Methyl (1S,2S,4S)-4-[(tert-butoxycarbonyl)amino]-2-methoxycyclohexanecarboxylate (racemic) (1.02 g, 3.55 mmol) were dissolved in ether (32 mL) and cooled to 0° C. Lithium tetrahydroaluminate (162 mg, 4.26 mmol) was added and the resulting mixture was stirred for 4 h. The reaction was quenched with 5 mL water at 0° C., then diluted with 5 mL 15% NaOH and 15 mL water after stirring for 30 min.", "The reaction mixture was filtered through a pad of Celite and washed with ethyl acetate.", "The aqueous layer was extracted with ethyl acetate (2×).", "The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated.", "The crude was purified with flash chromatography (eluting with a gradient of 0-80% ethyl acetate in hexanes) to give the desired product as white foam.", "LCMS calculated for C8H18NO2 (M+H-Boc)+: m/z=160.1; Found: 160.2.H NMR (300 MHz, CDCl3) δ 4.46 (1H, brs), 3.71-3.40 (3H, m), 3.37 (3H, s), 3.12 (2H, m), 2.48 (1H, m), 1.94 (1H, m), 1.71-1.50 (3H, m), 1.41 (9H, s), 1.05 (2H, m) ppm.", "Step 6.", "{(1R,2S,4S)-4-[(tert-Butoxycarbonyl)amino]-2-methoxycyclohexyl}methyl methanesulfonate To a solution of tert-butyl [(1S,3S,4R)-4-(hydroxymethyl)-3-methoxycyclohexyl]carbamate (racemic) (720 mg, 2.8 mmol) in dichloromethane (9 mL) was added methanesulfonyl chloride (0.430 mL, 5.56 mmol) at 0° C. The mixture was stirred at 0° C. for 1 h. The mixture was then concentrated and partitioned between ethyl acetate and water.", "The organic phase was concentrated and purified by flash chromatography (eluting with a gradient of 50% ethyl acetate in hexanes) to give the desired product (0.859 g, 92%).", "LCMS calculated for C9H20NO4S (M+H-Boc)+: m/z=238.1; Found: 238.0.Step 7.", "[(1R,2S,4S)-4-amino-2-methoxycyclohexyl]acetonitrile (racemic) A mixture of {(1R,2S,4S)-4-[(tert-butoxycarbonyl)amino]-2-methoxycyclohexyl}methyl methanesulfonate (661 mg, 1.96 mmol) and sodium cyanide (115 mg, 2.35 mmol) in DMSO (6 mL) was stirred at 90° C. overnight.", "After cooling to room temperature, the mixture was partitioned between ethyl acetate and brine.", "The organic layer was washed with water and brine, and concentrated to give the Boc-protected azide: LCMS [M+Na] 261.1.A solution of the intermediate in dichloromethane (9 mL) was treated with TFA (9 mL) and stirred at room temperature for 2 h. The reaction solution was concentrated to give the desired product as TFA salt.", "LCMS calculated for C9H17N2O (M+H)+: m/z=169.1; Found: 169.1.Step 8.", "{(1R,2S,4S)-2-Methoxy-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (racemic) A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (381 mg, 1.78 mmol), [(1R,2S,4S)-4-amino-2-methoxycyclohexyl]acetonitrile (racemic) (310 mg, 1.8 mmol) and N,N-diisopropylethylamine (1.2 mL, 7.1 mmol) in isopropyl alcohol (4.2 mL) was heated at 90° C. for 2 h. The crude was concentrated and purified with flash chromatography to give the desired product (469 mg, 76%).", "LCMS calculated for C15H19N4O3S (M+H)+: m/z=347.1; Found: 347.0.Step 9.", "{(1R,2S,4S)-4-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]-2-methoxycyclohexyl}acetonitrile (racemic) A mixture of {(1R,2S,4S)-2-methoxy-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (racemic) (401 mg, 1.16 mmol) and 10% palladium on carbon (0.20 g) in methanol (7.7 mL) was subjected to balloon pressure of H2 at room temperature for 2 h. The mixture was filtered and the filtrate was concentrated and purified with flash chromatography (eluting with 15% methanol in dichloromethane) to give the desired product (342 mg, 93%).", "LCMS calculated for C16H21N4OS (M+H)+: m/z=317.1; Found: 317.1.Step 10.", "((1R,2S,4S)-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}-2-methoxycyclohexyl)acetonitrile and ((1S,2R,4R)-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}-2-methoxycyclohexyl)acetonitrile A mixture of (2R)-2-hydroxypropanamide (40.6 mg, 0.456 mmol) and triethyloxonium tetrafluoroborate (82 mg, 0.43 mmol) in THF (2.3 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (0.45 mL) and added to a suspension of {(1R,2S,4S)-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-2-methoxycyclohexyl}acetonitrile (racemic) (44 mg, 0.14 mmol) in ethanol (0.45 mL).", "The resulting mixture was stirred at 80° C. for 1 h. The reaction mixture was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product as white solid (26 mg, 50%).", "LCMS calculated for C19H23N4O2S (M+H)+: m/z=371.2; Found: 371.0.Step 11.", "((1R,2S,4S)-2-Hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile trifluoacetate and ((1S,2R,4R)-2-hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile trifluoacetate To a solution of ((1R,2S,4S)-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}-2-methoxycyclohexyl)acetonitrile (diastereoisomer mixture) (23.0 mg, 0.0621 mmol) in acetonitrile (0.9 mL) was added iodotrimethylsilane (0.45 mL, 3.2 mmol).", "After stirring at 80° C. for 6 h, the reaction mixture was diluted with methanol and water and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% TFA, at flow rate of 60 mL/min) to give two peaks (isomer 1, 2.1 mg, 9.5%; isomer 2, 2.5 mg, 11%).", "Isomer 1 (first to elute): LCMS calculated for C18H21N4O2S (M+H)+: m/z=357.1; Found: 357.0.Isomer 2 (second to elute): LCMS calculated for C18H21N4O2S (M+H)+: m/z=357.1; Found: 357.0.Example 38.", "[(2R,5S)-5-(2-Methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]acetonitrile Step 1.", "{(2R,5S)-5-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}methanol A mixture of {(5S)-5-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate (366 mg, 1.05 mmol) and 10% palladium on carbon (0.18 g) in methanol (7.0 mL) was subjected to balloon pressure of H2 at room temperature for 2 h. The mixture was filtered and treated with 1 M NaOH (1 mL) for 1 h. The mixture was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give two peaks in 5:1 ratio.", "The major peak is the title compound (154 mg, 58%).", "LCMS calculated for C13H18N3O2S (M+H)+: m/z=280.1; Found: 280.1.Step 2.", "[(2R,5S)-5-(2-Methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methanol To a solution of {(2R,5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}methanol (131 mg, 0.469 mmol) in acetic acid (1.3 mL) was added triethyl orthoacetate (275 μL, 1.50 mmol).", "The mixture was stirred at 120° C. for 30 min.", "After cooling to room temperature, the mixture was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product as white solid (60 mg, 42%).", "LCMS calculated for C15H18N3O2S (M+H)+: m/z=304.1; Found: 304.1.Step 3: [(2R,5S)-5-(2-Methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methyl 4-methylbenzenesulfonate To a solution of [(2R,5S)-5-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methanol (60.1 mg, 0.198 mmol) in methylene chloride (2.3 mL) and pyridine (51 μL, 0.62 mmol) was added p-toluenesulfonyl chloride (38.7 mg, 0.203 mmol) and 4-dimethylaminopyridine (1.2 mg, 0.010 mmol) at 0° C. The reaction mixture was allowed to warm to room temperature overnight.", "The reaction mixture was concentrated, diluted with methanol, and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (50 mg, 55%).", "LCMS calculated for C22H24N3O4S2 (M+H)+: m/z=458.1; Found: 458.1.Step 4.", "[(2R,5S)-5-(2-Methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]acetonitrile To a mixture of [(2R,5S)-5-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methyl 4-methylbenzenesulfonate (50.2 mg, 0.110 mmol) and sodium cyanide (9.1 mg, 0.19 mmol) in DMF (1.1 mL) was added 1.0 M sulfuric acid in DMF (9 μL, 0.009 mmol).", "The reaction solution was stirred at 50° C. overnight.", "After cooling, the mixture was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (15.2 mg, 44%).", "LCMS calculated for C16H17N4OS (M+H)+: m/z=313.1; Found: 313.0.Example 39.", "[(2R,5S)-5-(2-Ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]acetonitrile Step 1.", "[(2R,5S)-5-(2-Ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methanol To a solution of {(2R,5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}methanol (115 mg, 0.412 mmol) in acetic acid (1.1 mL) was added propane, 1,1,1-triethoxy- (265 μL, 1.32 mmol).", "The resulting mixture was stirred at 120° C. for 30 min.", "After cooling to room temperature, the mixture was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product as white solid (74.8 mg, 57%).", "LCMS calculated for C16H20N3O2S (M+H)+: m/z=318.1; Found: 318.1.Step 2: [(2R,5S)-5-(2-Ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methyl 4-methylbenzenesulfonate This compound was prepared according to the procedure described in Example 38, Step 3, using [(2R,5S)-5-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methanol instead of [(2R,5S)-5-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methanol as starting material.", "LCMS calculated for C23H26N3O4S2 (M+H)+: m/z=472.1; Found: 472.0.Step 3.", "[(2R,5S)-5-(2-Ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]acetonitrile This compound was prepared according to the procedure described in Example 38, Step 4, using [(2R,5S)-5-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methyl 4-methylbenzenesulfonate instead of [(2R,5S)-5-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methyl 4-methylbenzenesulfonate as starting material.", "LCMS calculated for C17H19N4OS (M+H)+: m/z=327.1; Found: 327.0.1H NMR (DMSO-d6, 300 MHz) δ 8.88 (1H, s), 7.95 (1H, d, J=5.5 Hz), 7.61 (1H, d, J=5.5 Hz), 4.64 (1H, m), 4.21 (1H, m), 4.09 (1H, m), 3.93 (1H, m), 3.04 (2H, m), 2.83 (2H, m), 2.53 (1H, m), 2.13 (1H, m), 1.97 (1H, m), 1.67 (1H, m), 1.31 (3H, t, J=7.4 Hz) ppm.", "Example 40.", "[(1R,2S,4S)-4-(2-Ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-hydroxycyclohexyl]acetonitrile and [(1S,2R,4R)-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-hydroxycyclohexyl]acetonitrile Step 1.", "[(1R,2S,4S)-4-(2-Ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-methoxycyclohexyl]acetonitrile (racemic) This compound was prepared according to the procedure of Example 34, steps 12, using {(1R,2S,4S)-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-2-methoxycyclohexyl}acetonitrile (racemic) and propane, 1,1,1-triethoxy- as the starting material.", "LCMS calculated for Cl9H23N4OS (M+H)+: m/z=355.2; Found: 355.1.Step 2.", "[(1R,2S,4S)-4-(2-Ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-hydroxycyclohexyl]acetonitrile and [(1S,2R,4R)-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-hydroxycyclohexyl]acetonitrile In a microwave vial, iodotrimethylsilane (0.20 mL, 1.4 mmol) was added to a solution of [(1R,2S,4S)-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-methoxycyclohexyl]acetonitrile (racemic) (10 mg, 0.03 mmol) in acetonitrile (0.3 mL).", "The vial was capped, and the mixture heated at 80° C. overnight.", "The reaction was quenched with a few drops of water.", "The mixture was then further diluted and purified using prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product as racemic mixture.", "The racemic mixture was separated by chiral column (Chiralcel AD-H, 5 uM, 20×250 mm, 80% EtOH/hexanes, flow rate: 18 mL/min) to give two peaks.", "Isomer 1 (first to elute): LCMS calculated for C18H21N4OS (M+H)+: m/z=341.1; Found: 341.1.Isomer 2 (second to elute): LCMS calculated for C18H21N4OS (M+H)+: m/z=341.1; Found: 341.1.Example 41.", "[(1R,2S,4S)-4-(2-Methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-hydroxycyclohexyl]acetonitrile and [(1S,2R,4R)-4-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-hydroxycyclohexyl]acetonitrile Step 1.", "[(1R,2S,4S)-4-(2-Methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-methoxycyclohexyl]acetonitrile (racemic) This compound was prepared according to the procedure of Example 34, steps 12, using {(1R,2S,4S)-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-2-methoxycyclohexyl}acetonitrile (racemic) and triethyl orthoacetate as the starting material.", "LCMS calculated for C18H21N4OS (M+H)+: m/z=341.1; Found: 341.1.Step 2.", "[(1R,2S,4S)-4-(2-Methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-hydroxycyclohexyl]acetonitrile and [(1S,2R,4R)-4-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-hydroxycyclohexyl]acetonitrile This compound was prepared according to the procedure described in Example 40, Step 2, using [(1R,2S,4S)-4-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-methoxycyclohexyl]acetonitrile (racemic) instead of [(1R,2S,4S)-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-2-methoxycyclohexyl]acetonitrile (racemic) as starting material.", "The racemic mixture was separated by chiral column (Chiralcel AD-H, 5 uM, 20×250 mm, 80% EtOH/hexanes, flow rate: 18 mL/min) to give two peaks.", "Isomer 1 (first to elute): LCMS calculated for C17H19N4OS (M+H)+: m/z=327.1; Found: 327.0.Isomer 2 (second to elute): LCMS calculated for C17H19N4OS (M+H)+: m/z=327.1; Found: 327.0.Example 42.", "[(2R,5S)-5-(2-Isopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]acetonitrile Step 1: [(2R,5S)-5-(2-Isopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methanol A mixture of 2-methylpropanamide (71.4 mg, 0.820 mmol) and triethyloxonium tetrafluoroborate (154 mg, 0.812 mmol) in THF (2 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (0.5 mL) and added to a suspension of {(2R,5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}methanol (69.2 mg, 0.248 mmol) in ethanol (1.7 mL).", "The mixture was stirred at 80° C. for 1 h. The reaction mixture was cooled to room temperature, diluted with methanol, and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product.", "LCMS calculated for C17H22N3O2S (M+H)+: m/z=332.1; Found: 332.1.Step 2 [(2R,5S)-5-(2-Isopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methyl 4-methylbenzenesulfonate This compound was prepared according to the procedure described in Example 38, Step 3, using [(2R,5S)-5-(2-isopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methanol instead of [(2R,5S)-5-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methanol as starting material.", "LCMS calculated for C24H28N3O4S2 (M+H)+: m/z=486.1; Found: 486.0.Step 3.", "[(2R,5S)-5-(2-Isopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]acetonitrile This compound was prepared according to the procedure described in Example 38, Step 4, using [(2R,5S)-5-(2-isopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methyl 4-methylbenzenesulfonate instead of [(2R,5S)-5-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methyl 4-methylbenzenesulfonate as starting material.", "1H NMR (CDCl3, 300 MHz) δ 9.06 (1H, s), 7.64 (1H, d, J=5.5 Hz), 7.54 (1H, d, J=5.5 Hz), 4.59 (2H, m), 4.04 (2H, m), 3.28 (1H, m), 2.85 (1H, m), 2.64 (2H, m), 2.13 (2H, m), 1.81 (1H, m), 1.44 (6H, m) ppm.", "LCMS calculated for C18H21N4OS (M+H)+: m/z=341.1; Found: 341.0.Example 43.", "[(2R,5S)-5-(2-Cyclopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]acetonitrile Step 1: [(2R,5S)-5-(2-Cyclopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methanol A mixture of cyclopropanecarboxamide (72.6 mg, 0.853 mmol) and triethyloxonium tetrafluoroborate (0.161 g, 0.845 mmol) in THF (2 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (0.48 mL) and added to a suspension of {(2R,5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}methanol (72.0 mg, 0.258 mmol) in ethanol (1.8 mL).", "The mixture was stirred at 80° C. for 1 h. The reaction mixture was cooled to room temperature, diluted with methanol, and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product.", "LCMS calculated for C17H20N3O2S (M+H)+: m/z=330.1; Found: 330.0.Step 2 [(2R,5S)-5-(2-Cyclopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methyl 4-methylbenzenesulfonate This compound was prepared according to the procedure described in Example 38, Step 3, using [(2R,5S)-5-(2-cyclopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methanol instead of [(2R,5S)-5-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methanol as starting material.", "LCMS calculated for C24H26N3O4S2 (M+H)+: m/z=484.1; Found: 484.0.Step 3.", "[(2R,5S)-5-(2-Cyclopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]acetonitrile This compound was prepared according to the procedure described in Example 38, Step 4, using [(2R,5S)-5-(2-cyclopropyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methyl 4-methylbenzenesulfonate instead of [(2R,5S)-5-(2-methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]methyl 4-methylbenzenesulfonate as starting material.", "LCMS calculated for C18H19N4OS (M+H)+: m/z=339.1; Found: 339.0.Example 44.", "((2S,5R)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile Step 1: tert-Butyl [(1R)-1-(hydroxymethyl)prop-2-en-1-yl]carbamate To a solution of (2R)-2-aminobut-3-en-1-ol hydrochloride (0.94 g, 7.6 mmol) (from Astatech Inc.) in ethanol (30 mL) was added triethylamine (1.27 mL, 9.13 mmol) and di-tert-butyldicarbonate (1.99 g, 9.13 mmol).", "The reaction solution was stirred at room temperature overnight, then concentrated and purified with flash chromatography (eluting with a gradient of 0-50% ethyl acetate in hexanes) to give the desired product as colorless oil.", "Step 2: tert-Butyl [(1R)-1-({[1-(hydroxymethyl)prop-2-en-1-yl]oxy}methyl)prop-2-en-1-yl]carbamate A flask charged with tert-butyl [(1R)-1-(hydroxymethyl)prop-2-en-1-yl]carbamate (1.88 g, 10.0 mmol), tris(dibenzylideneacetone)dipalladium(0) (134 mg, 0.146 mmol), N,N′-(1R,2R)-cyclohexane-1,2-diylbis[2-(diphenylphosphino)-1-naphthamide] (350 mg, 0.44 mmol), 4-dimethylaminopyridine (370 mg, 3.0 mmol) was purged with N2 three times, and then filled with methylene chloride (100 mL), followed by addition of 1.0 M triethylborane in THF (0.294 mL, 0.294 mmol).", "After stirring for 10 min.", "2-vinyloxirane (0.704 g, 10.0 mmol) was added, and the resulting mixture was stirred overnight.", "The reaction was diluted with dichloromethane and sat.", "NaHCO3 solution.", "The organic layer was separated and dried over Na2SO4, filtered and concentrated.", "The crude residue was purified with flash chromatography (eluting with 0-50% ethyl acetate/hexanes) to give the desired product (0.271 g, 49%).", "1H NMR (300 MHz, CDCl3) δ 5.85 (1H, m), 5.67 (1H, m), 5.84-5.17 (4H, m), 4.83 (1H, m), 4.30 (1H, br s), 3.83 (1H, m), 3.69 (1H, dd, J=4.5 and 6.9 Hz), 3.54 (2H, m), 3.36 (1H, dd, J=4.5 and 6.9 Hz), 1.45 (9H, s) ppm.", "Step 3: 2-({(2R)-2-[(tert-Butoxycarbonyl)amino]but-3-en-1-yl}oxy)but-3-en-1-yl acetate This compound was prepared according to the procedure described in Example 19, Step 4, using tert-butyl [(1R)-1-({[1-(hydroxymethyl)prop-2-en-1-yl]oxy}methyl)prop-2-en-1-yl]carbamate instead of tert-butyl [(1S)-1-({[1-(hydroxymethyl)prop-2-en-1-yl]oxy}methyl)prop-2-en-1-yl]carbamate as starting material.", "Step 4.", "{(5S)-5-[(tert-Butoxycarbonyl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate This compound was prepared according to the procedure described in Example 19, Step 5, using 2-({(2R)-2-[(tert-butoxycarbonyl)amino]but-3-en-1-yl}oxy)but-3-en-1-yl acetate instead of 2-({(2S)-2-[(tert-butoxycarbonyl)amino]but-3-en-1-yl}oxy)but-3-en-1-yl acetate as starting material.", "Step 5.", "[(5R)-5-Amino-5,6-dihydro-2H-pyran-2-yl]methyl acetate This compound was prepared according to the procedure described in Example 19, Step 6, using {(5R)-5-[(tert-butoxycarbonyl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate instead of {(5S)-5-[(tert-butoxycarbonyl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate as starting material.", "LCMS calculated for C8H14NO3 (M+H)+: m/z=172.1; Found: 172.1.Step 6.", "{(5R)-5-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate This compound was prepared according to the procedure described in Example 19, Step 7, using [(5R)-5-amino-5,6-dihydro-2H-pyran-2-yl]methyl acetate instead of [(5S)-5-amino-5,6-dihydro-2H-pyran-2-yl]methyl acetate as starting material.", "LCMS calculated for C15H16N3O5S (M+H)+: m/z=350.1; Found: 350.0.Step 7.", "{(5R)-5-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}methyl acetate This compound was prepared according to the procedure described in Example 19, Step 8, using {(5R)-5-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate instead of {(5S)-5-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate as starting material.", "LCMS calculated for C15H20N3O3S (M+H)+: m/z=322.1; Found: 322.0.Step 8.", "(1R)-1-{1-[(3R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol This compound was prepared according to the procedure described in Example 19, Step 9, using {(5R)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}methyl acetate instead of {(5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}methyl acetate as starting material.", "LCMS calculated for C16H20N3O3S (M+H)+: m/z=334.1; Found: 334.0.Step 9: ((2S,5R)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate and ((2R,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate This compound was prepared according to the procedure described in Example 20, Step 1, using (1R)-1-{1-[(3R)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol instead of (1R)-1-{1-[(3S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol as starting material.", "LCMS calculated for C23H26N3O5S2 (M+H)+: m/z=488.1; Found: 488.1.Step 10: ((2S,5R)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile This compound was prepared according to the procedure described in Example 20, Step 2, using ((2S,5R)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate instead of ((2R,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate as starting material.", "LCMS calculated for C17H19N4O2S (M+H)+: m/z=343.1; Found: 343.0.Example 45: ((2R,5S)-5-{2-[(1S)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile Step 1: (1S)-1-{1-[(3S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol A mixture of (2S)-2-hydroxypropanamide (86.6 mg, 0.972 mmol) and triethyloxonium tetrafluoroborate (185 mg, 0.972 mmol) in THF (2 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (0.50 mL) and added to a suspension of {(2R,5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}methanol (65.0 mg, 0.233 mmol) in ethanol (1.8 mL).", "The mixture was stirred at 80° C. for 1 h. The mixture was cooled to room temperature, diluted with methanol, and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product as white solid (45 mg, 58%).", "LCMS calculated for C16H20N3O3S (M+H)+: m/z=334.1; Found: 334.Step 2: ((2R,5S)-5-{2-[(1S)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate To a solution of (1S)-1-{1-[(3S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol (48.0 mg, 0.144 mmol) in methylene chloride (2.09 mL) and pyridine (70.4 μL, 0.871 mmol) was added p-toluenesulfonyl chloride (35.0 mg, 0.184 mmol) and 4-dimethylaminopyridine (1.1 mg, 0.0092 mmol).", "The reaction mixture was stirred at room temperature overnight.", "The reaction mixture was concentrated, diluted with methanol, and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product as white solid (42 mg, 60%).", "LCMS calculated for C23H26N3O5S2 (M+H)+: m/z=488.1; Found: 488.1.Step 3.", "((2R,5S)-5-{2-[(1S)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile This compound was prepared according to the procedure described in Example 20, Step 2, using ((2R,5S)-5-{2-[(1S)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate instead of ((2R,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate as starting material.", "LCMS calculated for C17H19N4O2S (M+H)+: m/z=343.1; Found: 343.0.Example 46: [4-(8-Methylpyrazolo[1,5-c]thieno[2,3-e]pyrimidin-9-yl)phenyl]acetonitrile Step 1: 3-Bromo-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazole To a solution of 3-bromo-5-methyl-1H-pyrazole (from Ark Pharm, 6.4 g, 40 mmol) in tetrahydrofuran (263 mL) at 0° C. was added sodium hydride (3.2 g, 80 mmol).", "After stirring for 30 min, [β-(trimethylsilyl)ethoxy]methyl chloride (8.4 mL, 48 mmol) was added and the reaction mixture was allowed to warm to room temperature over 2 h. The reaction mixture was diluted with ethyl acetate and water.", "The aqueous layer was extracted with ethyl acetate.", "The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated.", "The crude was purified with flash chromatography (eluting with a gradient of 0-15% ethyl acetate in hexanes) to give the desired product as colorless oil (12 g, 100%).", "LCMS calculated for C10H20BrN2OSi (M+H)+: m/z=291.1; Found: 291.0.Step 2: tert-Butyl (2-bromo-3-thienyl)carbamate To a solution of tert-butyl 3-thienylcarbamate (from Ark Pharm, 3.97 g, 19.9 mmol) in methylene chloride (190 mL) was added N-bromosuccinimide (3.54 g, 19.9 mmol) portionwise.", "The resulting mixture was heated at 40° C. for 20 min.", "The reaction solution was concentrated and the precipitate was filtered and the filtrate was purified with flash chromatography (eluting with a gradient of 0-10% ethyl acetate in hexanes) to give the desired product as white solid.", "LCMS calculated for C5H5BrNO2S (M+H-t-Bu)+: m/z=221.9; Found: 221.8.Step 3: tert-Butyl [2-(trimethylstannyl)-3-thienyl]carbamate To a solution of tert-butyl (2-bromo-3-thienyl)carbamate (4.81 g, 17.3 mmol) in THF (42 mL) was added 2.5 M n-butyllithium in hexanes (15.2 mL, 38.0 mmol) dropwise at −78° C. After stirring for 45 min, 1.0 M chlorotrimethylstannane in THF (19.0 mL, 19.0 mmol) was added.", "The resulting mixture was allowed to warm to room temperature.", "The reaction was quenched with brine (70 mL) and extracted with ethyl acetate (2×).", "The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated to give the desired product.", "1H NMR (300 MHz, CDCl3) δ 7.49 (1H, d, J=4.8 Hz), 7.13 (1H, d, J=4.8 Hz), 6.39 (1H, brs), 1.50 (9H, s), 0.36 (9H, s) ppm.", "Step 4: tert-Butyl [2-(5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazol-3-yl)-3-thienyl]carbamate A microwave vial charge with 3-bromo-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazole (2.99 g, 10.3 mmol), tert-butyl [2-(trimethylstannyl)-3-thienyl]carbamate (4.40 g, 11.3 mmol), cesium fluoride (3.4 g, 23 mmol) and pre-milled palladium acetate and dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (190 mg, 0.20 mmol) was purged with nitrogen three times.", "1,2-Dimethoxyethane (10 mL) was added and resulting suspension was heated at 80° C. overnight.", "After cooling to room temperature, the mixture was diluted with ethyl acetate and filtered through a pad of silica gel.", "The silica gel pad was washed with ethyl acetate.", "The solvent was removed in vacuo and the residue was purified with flash chromatography (eluting with a gradient of 0-20% ethyl acetate in hexanes) to give the desired product.", "LCMS calculated for C19H32N3O3SSi (M+H)+: m/z=410.2; Found: 410.2.Step 5: 8-Methylpyrazolo[1,5-c]thieno[2,3-e]pyrimidine To a solution of tert-butyl [2-(5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazol-3-yl)-3-thienyl]carbamate (3.2 g, 7.8 mmol) in methylene chloride (23 mL) was added trifluoroacetic acid (23 mL).", "After stirring at room temperature for 5 h, the solvent was removed.", "The residue was dissolved in THF (40 mL) and treated with 1,1-dimethoxy-N,N-dimethylmethanamine (1.56 mL, 11.7 mmol).", "The resulting solution was heated at 80° C. for 1 h. The solvent was removed under reduced pressure.", "The crude was purified with flash chromatography (eluting with a gradient of 0-20% ethyl acetate in hexanes) to give the desired product as white solid.", "1H NMR (300 MHz, CD3OD) δ 9.09 (1H, s), 7.81 (1H, d, J=5.3 Hz), 7.45 (1H, d, J=5.3 Hz), 6.60 (1H, s), 2.49 (3H, s) ppm.", "LCMS calculated for C9H5N3S (M+H)+: m/z=190.0; Found: 190.0.Step 6: 9-Bromo-8-methylpyrazolo[1,5-c]thieno[2,3-e]pyrimidine To a solution of 8-methylpyrazolo[1,5-c]thieno[2,3-e]pyrimidine (1.01 g, 5.34 mmol) in methylene chloride (30 mL) was added N-bromosuccinimide (0.959 g, 5.39 mmol).", "After stirring for 1 h, the reaction solution was concentrated, and the resultant residue was purified with flash chromatography (eluting with a gradient of 0-20% ethyl acetate in hexanes) to give the desired product as whited solid.", "1H NMR (300 MHz, CD3OD) δ 9.11 (1H, s), 7.94 (1H, d, J=5.3 Hz), 7.52 (1H, d, J=5.3 Hz), 2.48 (3H, s) ppm.", "LCMS calculated for C9H7BrN3S (M+H)+: m/z=268.0; Found: 267.9.Step 7: [4-(8-Methylpyrazolo[1,5-c]thieno[2,3-e]pyrimidin-9-yl)phenyl]acetonitrile A microwave vial charged with 9-bromo-8-methylpyrazolo[1,5-c]thieno[2,3-e]pyrimidine (48.0 mg, 0.179 mmol), [4-(cyanomethyl)phenyl]boronic acid (from Aldrich, 51.9 mg, 0.322 mmol), sodium carbonate (47.4 mg, 0.448 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (1:1) (15 mg, 0.018 mmol), DMF (1.3 mL) and water (0.13 mL) was purged with N2 and then stirred at 95° C. for 10 h. The reaction was diluted with ethyl acetate and water.", "The organic layer was washed with brine, dried over MgSO4, filtered and concentrated.", "The crude was purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (35 mg, 64%).", "LCMS calculated for C17H13N4S (M+H)+: m/z=305.1; Found: 305.0.Example 47: [trans-4-(2-Ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile A mixture of {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (20.1 mg, 0.0702 mmol) and 1,1,1-triethoxypropane (0.0428 mL, 0.213 mmol) in acetic acid (0.2 mL) was stirred at 120° C. for 30 min.", "The mixture was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (13 mg, 57%).", "LCMS calculated for C18H21N4S (M+H)+: m/z=325.1; Found: 325.1.Example 48: [trans-4-(2-Methyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile This compound was prepared according to the procedure described in Example 47, using triethyl orthoacetate instead of propane, 1,1,1-triethoxy- as starting material.", "LCMS calculated for C17H19N4 (M+H)+: m/z=311.1; Found: 311.1.Example 49.", "((1R,3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclopentyl)acetonitrile trifluoroacetate Step 1.Ethyl (1R,3S)-3-aminocyclopentanecarboxylate trifluoroacetate To a solution of (1R,3S)-3-[(tert-butoxycarbonyl)amino]cyclopentanecarboxylic acid (from Acros, 0.46 g, 2.0 mmol) in N,N-dimethylformamide (4.6 mL) was added sodium bicarbonate (0.34 g, 4.0 mmol) and iodoethane (0.64 mL, 8.0 mmol).", "The resulting mixture was stirred overnight at room temperature.", "The mixture was diluted with ethyl acetate then washed with sat.", "sodium bicarbonate, water (2×) and brine.", "The organic was dried (Na2SO4), filtered, and concentrated to give the crude ester.", "To the crude ester was added methylene chloride (3.0 mL) and trifluoroacetic acid (1.0 mL, 13 mmol).", "The resulting solution was stirred for 1 h, then concentrated and dried in vacuo to give 0.25 g (46%) of the title compound.", "LCMS calculated for C8H16NO2 (M+H)+: m/z=158.1; Found: 158.1.Step 2.Ethyl (1R,3S)-3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino] cyclopentanecarboxylate To a stirred mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.18 g, 0.84 mmol) and ethyl (1R,3S)-3-aminocyclopentanecarboxylate trifluoroacetate (0.25 g, 0.92 mmol) in isopropyl alcohol (2.3 mL) was added N,N-diisopropylethylamine (0.73 mL, 4.2 mmol).", "The resulting mixture was stirred at 90° C. for 100 min, and then the solvent was evaporated.", "The crude residue was purified on silica gel, eluted with 10-60% EtOAc in hexanes to give 0.15 g (55%) of the desired product.", "LCMS calculated for C15H8N3O4S (M+H)+: m/z=336.1; Found: 336.0.Step 3.", "{(1R,3S)-3-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclopentyl}methanol Lithium tetrahydroaluminate (20.4 mg, 0.537 mmol) was added to a solution of ethyl (1R,3S)-3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclopentanecarboxylate (0.15 g, 0.45 mmol) in tetrahydrofuran (4.0 mL) with stirring at about 0° C. The resulting mixture was kept cold and stirred for 40 min.", "Fieser workup was performed followed by filtration through Celite and concentrated.", "The crude was purified using silica gel, eluted with 40-100% EtOAc in hexanes to give 70 mg (50%) of the desired product.", "LCMS calculated for C13H16N3O3S (M+H)+: m/z=294.1; Found: 294.0.Step 4.", "{(1R,3S)-3-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclopentyl}acetonitrile Methanesulfonyl chloride (24.0 μL, 0.310 mmol) was added to a solution of {(1R,3S)-3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclopentyl}methanol (70 mg, 0.2 mmol) and triethylamine (66.5 μL, 0.477 mmol) in methylene chloride (2.1 mL) at about 0° C. with stirring.", "The resulting mixture was allowed to warm to room temperature and stir overnight.", "The mixture was diluted with dichloromethane then washed with water and brine.", "The organic was dried (MgSO4), filtered, and concentrated to give a bright yellow gum.", "To the crude mesylate was added dimethyl sulfoxide (2.0 mL) and sodium cyanide (22 mg, 0.45 mmol).", "The resulting mixture was stirred at room temperature.", "After 2 h, the temperature was increased to 80° C. and stirred for 3 h. After cooling, EtOAc and brine were added.", "The layers were separated and the organic washed with water (2×), dried (Na2SO4), filtered, and concentrated.", "The crude was purified on silica gel, eluted with 10-70% EtOAc in hexanes to give 8 mg (10%) of the desired product.", "LCMS calculated for C14H15N4O2S (M+H)+: m/z=303.1; Found: 303.0.Step 5.", "{(1R,3S)-3-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]cyclopentyl}acetonitrile A mixture of {(1R,3S)-3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclopentyl}acetonitrile (8 mg, 0.03 mmol) and 10% palladium on carbon (4 mg) in methanol (0.3 mL) was stirred under an atmosphere of H2 (balloon) overnight.", "The mixture was filtered and concentrated to give 7 mg of the desired product.", "LCMS calculated for C14H17N4S (M+H)+: m/z=273.1; Found: 273.0.Step 6.", "((1R,3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclopentyl)acetonitrile trifluoroacetate A mixture of (2R)-2-hydroxypropanamide (7.4 mg, 0.083 mmol) and triethyloxonium tetrafluoroborate (14.7 mg, 0.0776 mmol) in tetrahydrofuran (0.15 mL) was stirred at room temperature for 50 min, then concentrated.", "The residue was dissolved in ethanol (0.1 mL), and this solution was then added to a solution of {(1R,3S)-3-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclopentyl}acetonitrile (7.0 mg, 0.026 mmol) in ethanol (0.1 mL) in a vial.", "The resulting mixture was stirred at 80° C. for 1 h. After cooling, the mixture was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 30 mL/min) to give 3.6 mg (32%) the desired product as the TFA salt.", "LCMS calculated for C17H19N4OS (M+H)+: m/z=327.1; Found: 327.0.Example 50.Ethyl (3S)-3-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidine-1-carboxylate Step 1.tert-Butyl (3S)-3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (166 mg, 0.774 mmol), tert-butyl (3S)-3-aminopiperidine-1-carboxylate (from Aldrich, 186 mg, 0.929 mmol) and triethylamine (0.32 mL, 2.3 mmol) in isopropyl alcohol (1.8 mL) was stirred at 90° C. for 2 h. After cooling to room temperature, solids were observed.", "Water was added which caused more solids to form.", "The yellow solids were filtered, washed with water, and dried to give 0.26 g of the desired product.", "LCMS calculated for C17H23N4O4S (M+H)+: m/z=379.1; Found: 379.0.1H NMR (400 MHz, CDCl3) δ 9.40 (s, 1H), 9.29 (s, 1H), 7.84 (d, J=5.5 Hz, 1H), 7.49 (d, J=5.5 Hz, 1H), 4.42 (m, 1H), 3.83 (m, 1H), 3.46 (m, 3H), 2.12 (m, 1H), 1.83 (m, 3H), 1.41 (s, 9H) ppm.", "Step 2.tert-Butyl (3S)-3-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate A mixture of tert-butyl (3S)-3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate (0.26 g, 0.69 mmol) and 10% palladium on carbon (80 mg) in methanol (5.0 mL) was stirred under an atmosphere of H2 (balloon) overnight.", "The mixture was filtered through a pad of Celite and concentrated to give 0.24 g of the desired product.", "LCMS calculated for C17H25N4O2S (M+H)+: m/z=349.2; Found: 349.0.Step 3.tert-Butyl (3S)-3-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidine-1-carboxylate A mixture of (2R)-2-hydroxypropanamide (197 mg, 2.21 mmol) and triethyloxonium tetrafluoroborate (395 mg, 2.08 mmol) in tetrahydrofuran (4.0 mL) was stirred at room temperature for 75 min then concentrated.", "The residue was dissolved in ethanol (1.5 mL) and this solution was then added to a solution of tert-butyl (3S)-3-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]piperidine-1-carboxylate (0.24 g, 0.69 mmol) in ethanol (3.5 mL) in a vial.", "The resulting mixture was stirred at 80° C. for 2 h. The solvent was evaporated and the crude purified on silica gel, eluted with 0-10% MeOH in dichloromethane to give 250 mg (86%) of the desired product.", "LCMS calculated for C20H27N4O3S (M+H)+: m/z=403.2; Found: 403.1.Step 4.", "(1R)-1-{1-[(3S)-Piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride To a solution of tert-butyl (3S)-3-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidine-1-carboxylate (0.25 g, 0.62 mmol) in methylene chloride (3.5 mL) was added 4.0 M hydrogen chloride in 1,4-dioxane (1.2 mL, 5.0 mmol).", "A precipitate immediately formed.", "The reaction was stirred at room temperature for 2 h. The solvents were evaporated and the solids dried in vacuo to give 0.21 g of the product as the HCl salt.", "LCMS calculated for C15H19N4OS (M+H)+: m/z=303.1; Found: 303.0.Step 5.Ethyl (3S)-3-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidine-1-carboxylate To a mixture of (1R)-1-{1-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride (15 mg, 0.044 mmol) and triethylamine (18.5 μL, 0.133 mmol) in methylene chloride (0.3 mL) was added ethyl chloroformate (5.1 μL, 0.0531 mmol).", "The resulting mixture was stirred until completion then the solvent evaporated.", "The crude residue was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 5.6 mg (34%) of the desired product.", "LCMS calculated for C18H23N4O3S (M+H)+: m/z=375.1; Found: 375.0.1H NMR (300 MHz, CDCl3) δ 9.08 (d, J=1.3 Hz, 1H), 7.69 (dd, J=5.5 and 1.3 Hz, 1H), 7.62 (d, J=5.5 Hz, 1H), 5.21 (d, J=6.7 Hz, 1H), 4.83-4.68 (m, 1H), 4.43-4.23 (m, 2H), 4.15 (q, J=6.9 Hz, 2H), 3.93-3.66 (m, 1H), 3.18-3.01 (m, 1H), 2.76-2.60 (m, 1H), 2.20-2.10 (m, 1H), 2.00 (d, J=13.8 Hz, 1H), 1.79 (d, J=6.4 Hz, 3H), 1.70-1.61 (m, 2H), 1.30-1.16 (m, 3H) ppm.", "Example 51.3-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidin-1-yl)-3-oxopropanenitrile trifluoroacetate To a mixture of (1R)-1-{1-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride (15 mg, 0.044 mmol) (Example 50, step 4), cyanoacetic acid (4.5 mg, 0.053 mmol), and triethylamine (18.5 μL, 0.133 mmol) in methylene chloride (0.3 mL) was added N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (25.2 mg, 0.0664 mmol).", "The resulting mixture was stirred at room temperature.", "After 2 h, a second addition of cyanoacetic acid (4.5 mg, 0.053 mmol) was made and stirred overnight.", "The solvent was evaporated and the residue purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 30 mL/min) to give 3.4 mg (16%) of the desired product.", "LCMS calculated for C18H20N5O2S (M+H)+: m/z=370.1; Found: 370.0.Example 52.", "(1R)-1-{1-[(3S)-1-(4,4,4-Trifluorobutanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol This compound was prepared using procedures analogous to those for Example 51 with 4,4,4-trifluorobutanoic acid instead of cyanoacetic acid and without the second addition.", "The crude was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 9.5 mg (50%) of the desired product.", "LCMS calculated for C19H22F3N4O2S (M+H)+: m/z=427.1; Found: 427.0.Example 53.", "(1R)-1-(1-{(3S)-1-[3-(1H-Pyrazol-4-yl)propanoyl]piperidin-3-yl}-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol This compound was prepared using procedures analogous to those for Example 52, with 3-(1H-pyrazol-4-yl)propanoic acid (7.9 mg, 0.0567 mmol) instead of 4,4,4-trifluorobutanoic acid.", "The crude was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 6.5 mg (32%) of the desired product.", "LCMS calculated for C21H25N6O2S (M+H)+: m/z=425.2; Found: 425.1.1H NMR (300 MHz, CDCl3) δ 9.04 (s, 1H), 7.64 (dd, J=11.8 and 6.2 Hz, 1H), 7.57 (d, J=5.6 Hz, 1H), 7.44 (s, 1H), 7.27 (s, 1H), 5.26 (d, J=7.1 Hz, 1H), 4.82 (d, J=8.5 Hz, 2H), 4.07-3.86 (m, 2H), 3.58-3.45 (m, 1H), 3.36-3.24 (m, 1H), 2.96-2.56 (m, 6H), 2.22-1.89 (m, 2H), 1.78 (d, J=6.4 Hz, 4H) ppm.", "Example 54.", "(1R)-1-{1-[(3S)-1-(3-Pyridin-3-ylpropanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol This compound was prepared using procedures analogous to those for Example 52, with 3-pyridin-3-ylpropanoic acid (8.5 mg, 0.057 mmol) instead of 4,4,4-trifluorobutanoic acid.", "The crude was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 6.8 mg (33%) of the desired product.", "LCMS calculated for C23H26N5O2S (M+H)+: m/z=436.2; Found: 436.0.1H NMR (300 MHz, CDCl3) δ 9.09 (s, 1H), 8.52 (s, 1H), 8.45 (d, J=4.7 Hz, 1H), 8.30 (s, 1H), 7.70-7.56 (m, 2H), 7.29-7.25 (m, 1H), 5.28 (s, 1H), 4.92-4.61 (m, 2H), 4.06-3.81 (m, 0H), 3.56 (s, 1H), 3.20-3.09 (m, 1H), 3.00-2.88 (m, 2H), 2.78-2.60 (m, 5H), 2.20-2.00 (m, 1H), 1.86 (d, J=6.2 Hz, 3H), 1.80-1.65 (m, 2H) ppm.", "Example 55.", "(1R)-1-{1-[(3S)-1-(3-Phenylbutanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol This compound was prepared using procedures analogous to those for Example 52, with 3-phenylbutyric acid (9.3 mg, 0.057 mmol) instead of 4,4,4-trifluorobutanoic acid.", "The crude was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 8.3 mg (39%) of the desired product.", "LCMS calculated for C25H29N4O2S (M+H)+: m/z=449.2; Found: 449.0.Example 56.3-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidin-1-yl)propanenitrile To a solution of (1R)-1-{1-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride (15.0 mg, 0.0443 mmol) (Example 50, step 4) in acetonitrile (0.3 mL) was added 1,8-diazabicyclo[5.4.0]undec-7-ene (26 μL, 0.18 mmol), followed by 2-propenenitrile (5.8 μL, 0.089 mmol).", "The resulting mixture was stirred at room temperature overnight.", "The solvents were evaporated and the residue was purified by RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 5.3 mg (34%) of the desired product.", "LCMS calculated for C18H22N5OS (M+H)+: m/z=356.2; Found: 356.1.Example 57.1R)-1-{1-[(3S)-1-(3-Phenylpropanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol To a mixture of (1R)-1-{1-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride (15 mg, 0.044 mmol) (Example 50, step 4) and triethylamine (24.7 μL, 0.177 mmol) in N,N-dimethylformamide (0.3 mL) was added benzenepropanoyl chloride (8.6 μL, 0.058 mmol).", "The resulting mixture was stirred for 90 min at room temperature.", "The mixture was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 6.5 mg (34%) of the desired product.", "LCMS calculated for C24H27N4O2S (M+H)+: m/z=435.2; Found: 435.1.1H NMR (300 MHz, CDCl3) δ 9.07 (s, 1H), 7.71-7.66 (m, 1H), 7.65-7.57 (m, 1H), 7.34-7.27 (m, 2H), 7.26-7.16 (m, 2H), 7.12 (d, J=6.9 Hz, 1H), 5.21 (s, 1H), 4.83 (d, J=13.1 Hz, 2H), 4.78-4.64 (m, 1H), 4.04-3.87 (m, 1H), 3.61-3.23 (m, 3H), 3.04-2.85 (m, 2H), 2.77-2.60 (m, 2H), 2.15 (s, 1H), 1.97 (d, J=14.4 Hz, 1H), 1.81 (d, J=6.5 Hz, 2H), 1.50 (d, J=13.1 Hz, 2H) ppm.", "Example 58.4-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidin-1-yl)-4-oxobutanenitrile Step 1.4-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidin-1-yl)-4-oxobutanoic acid To a solution of (1R)-1-{1-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride (30.0 mg, 0.0885 mmol) (Example 50, step 4) and triethylamine (37.0 μL, 0.266 mmol) in methylene chloride (0.5 mL) was added 3-(carbomethoxy)propionyl chloride (12.0 μL, 0.0974 mmol).", "The resulting mixture was stirred at room temperature for 2 h. Water and dichloromethane were added and the layers separated.", "The organic was concentrated.", "The crude residue was taken up in methanol (0.5 mL), tetrahydrofuran (50 μL), and water (40 μL).", "Lithium hydroxide, monohydrate (18 mg, 0.44 mmol) was added and the mixture stirred at room temperature for 3 h. The mixture was made slightly acidic by adding 1N HCl then concentrated.", "The mixture was dissolved in dichloromethane, stirred, filtered and concentrated to give 37 mg of clean, crude acid.", "LCMS calculated for C19H23N4O4S (M+H)+: m/z=403.1; Found: 403.2.Step 2.4-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidin-1-yl)-4-oxobutanamide To a mixture of 4-((3S)-3-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidin-1-yl)-4-oxobutanoic acid (35 mg, 0.087 mmol), ammonium carbonate (42 mg, 0.43 mmol), and triethylamine (18.2 μL, 0.130 mmol) in N,N-dimethylformamide (0.6 mL) was added benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (76.9 mg, 0.174 mmol).", "The resulting mixture was stirred at room temperature for 2.5 h. The mixture was diluted with ethyl acetate then washed with sat.", "NaHCO3, water, and brine.", "LCMS showed most of the desired product remained in the aqueous layer.", "The aqueous layer was concentrated to give white solids.", "The solids were stirred in ˜1:1 MeOH/dichloromethane and then filtered to give 40 mg crude product.", "The crude was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 6 mg of the desired product.", "LCMS calculated for C19H24N5O3S (M+H)+: m/z=402.2; Found: 402.0.Step 3.4-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidin-1-yl)-4-oxobutanenitrile To a mixture of 4-((3S)-3-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidin-1-yl)-4-oxobutanamide (5.5 mg, 0.014 mmol) and triethylamine (9.6 μL, 0.069 mmol) in tetrahydrofuran (0.2 mL) stirring at about 0° C. was added trifluoroacetic anhydride (4.8 μL, 0.034 mmol).", "The resulting mixture was kept cold and stirred for 2 h. The mixture was concentrated then purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 3 mg (57%) of the desired product.", "LCMS calculated for C19H22N5O2S (M+H)+: m/z=384.1; Found: 384.2.Example 59.5-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidin-1-yl)-5-oxopentanenitrile This compound was prepared using procedures analogous to those for Example 58, with 3-carbomethoxybutrylchloride instead of 3-(carbomethoxy)propionyl chloride.", "Isolated 1.7 mg (31%) of the desired compound.", "LCMS calculated for C20H24N5O2S (M+H)+: m/z=398.2; Found: 398.2.Example 60.", "(1R)-1-{1-[1-(4,4,4-Trifluorobutyl)piperidin-4-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol Step 1.", "(1R)-1-(1-Piperidin-4-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol This compound was prepared using procedures analogous to those for Example 50, step 4, with tert-butyl 4-aminopiperidine-1-carboxylate (from Aldrich) instead of tert-butyl (3S)-3-aminopiperidine-1-carboxylate.", "LCMS calculated for C15H19N4OS (M+H)+: m/z=303.1; Found: 303.1.Step 2.", "(1R)-1-{1-[1-(4,4,4-Trifluorobutyl)piperidin-4-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol To a mixture of (1R)-1-(1-piperidin-4-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol (15.0 mg, 0.0496 mmol) and 4,4,4-trifluorobutanol (9.4 mg, 0.0744 mmol) in methylene chloride (0.3 mL) and N,N-dimethylformamide (0.2 mL) was added resin of tetramethylammonium triacetoxyborohydride (48.4 mg, 0.0992 mmol).", "The resulting mixture was stirred overnight.", "The mixture was filtered and concentrated then purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 7 mg (34%) of the desired product.", "LCMS calculated for C19H24F3N4OS (M+H)+: m/z=413.2; Found: 413.1.1H NMR (300 MHz, CDCl3) δ 9.06 (s, 1H), 7.71-7.60 (m, 2H), 5.21 (s, 1H), 4.72-4.58 (m, 1H), 3.70-3.57 (m, 6H), 3.13 (d, J=9.8 Hz, 2H), 2.89-2.66 (m, 1H), 2.49 (t, J=6.9 Hz, 2H), 2.34-2.18 (m, 2H), 1.96 (s, 1H), 1.86-1.74 (m, 2H), 1.67 (s, 2H) ppm.", "Example 61.", "(4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}piperidin-1-yl)acetonitrile trifluoroacetate A mixture of (1R)-1-(1-piperidin-4-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol (15 mg, 0.050 mmol) (Example 60, step 1), bromoacetonitrile (4.2 μL, 0.060 mmol) and triethylamine (20.7 μL, 0.149 mmol) in acetonitrile (0.3 mL) was stirred at rt for 4 h. The mixture was diluted and purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 30 mL/min) to give 4.2 mg (18%) of the desired product.", "LCMS calculated for C17H20N5OS (M+H)+: m/z=342.1; Found: 342.0.Example 62.3-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}pyrrolidin-1-yl)propanenitrile Step 1.", "(1R)-1-{1-[(3S)-Pyrrolidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride This compound was prepared using procedures analogous to those for Example 50, step 4, with tert-butyl (3S)-3-aminopyrrolidine-1-carboxylate (from Aldrich) instead of tert-butyl (3S)-3-aminopiperidine-1-carboxylate.", "LCMS calculated for C14H7N4OS (M+H)+: m/z=289.1; Found: 289.0.1H NMR (300 MHz, CD3OD) δ 9.39 (s, 1H), 8.48 (d, J=5.7 Hz, 1H), 7.91 (d, J=5.7 Hz, 1H), 6.10-5.97 (m, 1H), 5.35 (q, J=6.4 Hz, 1H), 4.11-3.91 (m, 3H), 3.68 (dt, 1H), 3.42 (s, 1H), 2.99-2.77 (m, 2H), 1.84 (d, J=6.4 Hz, 2H), 1.60 (s, 1H), 1.32 (dd, J=6.0 and 3.2 Hz, 2H) ppm.", "Step 2.3-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}pyrrolidin-1-yl)propanenitrile To a solution of (1R)-1-{1-[(3S)-pyrrolidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride (15 mg, 0.046 mmol) in acetonitrile (0.3 mL) was added 1,8-diazabicyclo[5.4.0]undec-7-ene (28 μL, 0.18 mmol) followed by 2-propenenitrile (6.1 μL, 0.092 mmol).", "The resulting mixture was stirred at room temperature for 3 h. The mixture was further diluted and purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 5.7 mg (36%) of the desired product.", "LCMS calculated for C17H20N5OS (M+H)+: m/z=342.1; Found: 342.1.Example 63.3-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}pyrrolidin-1-yl)-3-oxopropanenitrile This compound was prepared using procedures analogous to those for Example 51, with (1R)-1-{1-[(3S)-pyrrolidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride (Example 62, step 1) instead of (1R)-1-{1-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride.", "The crude product was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 7 mg (43%) of the desired product.", "LCMS calculated for C17H18N5O2S (M+H)+: m/z=356.1; Found: 356.0.Example 64.", "(1R)-1-{1-[(3S)-1-(4,4,4-Trifluorobutyl)pyrrolidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol This compound was prepared using procedures analogous to those for Example 60, step 2, with (1R)-1-{1-[(3S)-pyrrolidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride (Example 62, step 1) instead of (1R)-1-(1-piperidin-4-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol.", "LCMS calculated for C18H22F3N4OS (M+H)+: m/z=399.1; Found: 399.1.H NMR (300 MHz, CDCl3) δ 9.08 (s, 1H), 7.68 (d, J=5.5 Hz, 1H), 7.61 (d, J=5.5 Hz, 1H), 5.59 (dd, J=8.2 and 3.6 Hz, 1H), 5.27 (q, J=6.4 Hz, 1H), 3.49-3.30 (m, 2H), 2.83 (dd, J=10.5 and 8.2 Hz, 1H), 2.74-2.52 (m, 5H), 2.26-2.09 (m, 2H), 1.81 (t, J=7.0 Hz, 6H) ppm.", "Example 65.4-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}pyrrolidin-1-yl)butanenitrile To a mixture of (1R)-1-{1-[(3S)-pyrrolidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride (15 mg, 0.046 mmol) and N,N-diisopropylethylamine (24 μL, 0.14 mmol) in acetonitrile (0.2 mL) was added butanenitrile, 4-bromo- (5.1 μL, 0.051 mmol).", "The resulting mixture was stirred at rt for 4 h. The mixture was diluted and purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 6.3 mg (38%) of the desired product.", "LCMS calculated for C18H22N5OS (M+H)+: m/z=356.2; Found: 356.0.Example 66.5-((3S)-3-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}pyrrolidin-1-yl)pentanenitrile This compound was prepared using procedures analogous to those for Example 65, with 5-bromovaleronitrile instead of butanenitrile, 4-bromo-.", "LCMS calculated for C19H24N5OS (M+H)+: m/z=370.2; Found: 370.1.H NMR (300 MHz, DMSO-d6) δ 8.98 (s, 1H), 8.02 (d, J=5.5 Hz, 1H), 7.67 (d, J=5.5 Hz, 1H), 5.91 (s, 1H), 5.67-5.57 (m, 1H), 5.29 (s, 1H), 3.26-3.10 (m, 2H), 3.04 (t, J=9.1 Hz, 1H), 2.80 (d, J=8.4 Hz, 1H), 2.70-2.30 (m, 7H) (overlap with solvent), 1.72-1.56 (m, 6H) ppm.", "Example 67.", "((1R,2R,4S)-2-Amino-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile Step 1.Methyl (1S,6R)-6-{[(benzyloxy)carbonyl]amino}cyclohex-3-ene-1-carboxylate To a solution of (1R,6S)-6-(methoxycarbonyl)cyclohex-3-ene-1-carboxylic acid (5.0 g, 27 mmol) (from Alfa Aesar) in toluene (50.0 mL) stirring under N2 was added triethylamine (9.1 mL, 65 mmol) followed by diphenylphosphonic azide (5.85 mL, 27.1 mmol).", "The resulting mixture was stirred at 85° C. overnight (18 h).", "Benzyl alcohol (2.81 mL, 27.1 mmol) was added and the mixture heated to reflux (135° C.) and stirred overnight.", "After cooling, the mixture was diluted with EtOAc and then washed with sat.", "NaHCO3 (2×), water and brine.", "The organic layer was dried (Na2SO4), filtered, and concentrated.", "The residue was dried in vacuo to give 7.8 g of yellow oil.", "LCMS calculated for C16H20NO4 (M+H)+: m/z=290.1; Found: 290.0.1H NMR (300 MHz, CDCl3) δ 7.38-7.27 (m, 5H), 5.62 (q, J=10.1 Hz, 2H), 5.39 (d, J=8.9 Hz, 1H), 5.07 (s, 2H), 4.28-4.19 (m, 1H), 3.66 (s, 3H), 2.81 (d, J=3.2 Hz, 1H), 2.56-2.12 (m, 4H) ppm.", "Step 2.Methyl (1R,3S,4R,6S)-4-{[(benzyloxy)carbonyl]amino}-7-oxabicyclo[4.1.O]heptane-3-carboxylate m-Chloroperbenzoic acid (5.56 g, 32.2 mmol) was added to a solution of methyl (1S,6R)-6-{[(benzyloxy)carbonyl]amino}cyclohex-3-ene-1-carboxylate (7.8 g, 27 mmol) in methylene chloride (150 mL) with stirring at about 0° C. The mixture was slowly warmed to room temperature and stirred overnight.", "The mixture was diluted with dichloromethane then washed with sat.", "NaHCO3 (3×).", "The organic layer was dried (MgSO4), filtered, and concentrated.", "The crude was purified on silica gel, eluted with 0-50% EtOAc in hexanes to give 4.7 g (57%) of the desired product as a white solid.", "LCMS calculated for C16H20NO5 (M+H)+: m/z=306.1; Found: 306.0.1H NMR (300 MHz, CDCl3) δ 7.37-7.29 (m, 5H), 5.75 (d, J=9.9 Hz, 1H), 5.04 (s, 2H), 4.09 (dtd, J=14.0, 6.8, 6.0, and 3.2 Hz, 1H), 3.65 (s, 3H), 3.18 (d, J=5.9 Hz, 2H), 2.60 (dd, J=15.5 and 7.3 Hz, 1H), 2.48 (td, J=7.3, 6.6, and 3.2 Hz, 1H), 2.23-2.01 (m, 3H) ppm.", "Step 3.Methyl (1S,2R,4R)-2-{[(benzyloxy)carbonyl]amino}-4-hydroxycyclohexanecarboxylate To a mixture of methyl (1R,3S,4R,6S)-4-{[(benzyloxy)carbonyl]amino}-7-oxabicyclo[4.1.0]heptane-3-carboxylate (1.9 g, 6.2 mmol) in ethanol (30.0 mL) was added sodium tetrahydroborate (0.471 g, 12.4 mmol).", "The resulting mixture was stirred overnight (22 h) at room temperature.", "The reaction was quenched with sat.", "NH4Cl, then most of the solvent evaporated.", "The residue was taken up in EtOAc and washed with water, dried (Na2SO4), filtered and concentrated.", "The crude was purified on silica gel, eluted with 40-100% EtOAc in hexanes to give 0.75 g (39%) of the desired product.", "LCMS calculated for C16H22NO5 (M+H)+: m/z=308.1; Found: 308.0.1H NMR (300 MHz, CDCl3) δ 7.36-7.28 (m, 5H), 6.02 (d, J=9.0 Hz, 1H), 5.05 (s, 2H), 4.03 (s, 1H), 3.87 (s, 1H), 3.64 (s, 3H), 2.68 (s, 1H), 2.22-2.11 (m, 1H), 1.97-1.67 (m, 5H), 1.42 (s, 1H) ppm.", "Step 4.", "(1S,2R,4R)-2-{[(benzyloxy)carbonyl]amino}-4 [(methylsulfonyl)oxy]cyclohexanecarboxylate Methanesulfonyl chloride (79.6 μL, 1.03 mmol) was added to a mixture of methyl (1S,2R,4R)-2-{[(benzyloxy)carbonyl]amino}-4-hydroxycyclohexanecarboxylate (243 mg, 0.791 mmol) and triethylamine (0.22 mL, 1.6 mmol) in methylene chloride (4.0 mL) with stirring at about 0° C. The resulting mixture was kept cold and stirred for 2 h. The mixture was diluted with dichloromethane then washed with water and brine.", "The organic layer was dried (MgSO4), filtered, and concentrated to give a white solid.", "LCMS calculated for C17H24NO7S (M+H)+: m/z=386.1; Found: 386.0.Step 5.Methyl (1S,2R,4S)-4-azido-2-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylate To a solution of methyl (1S,2R,4R)-2-{[(benzyloxy)carbonyl]amino}-4-[(methylsulfonyl)oxy]cyclohexanecarboxylate (0.30 g, 0.78 mmol) in N,N-dimethylformamide (2.6 mL) was added sodium azide (0.20 g, 3.1 mmol).", "The reaction was heated to 80° C. and stirred for 2.5 h. After cooling, the reaction mixture was poured into sat.", "NaHCO3/water and extracted with EtOAc (3×).", "The combined extracts were washed with brine, dried (Na2SO4), and concentrated.", "The crude was purified on silica gel, eluting with 0-40% EtOAc in hexanes to give 187 mg (72%) of the desired product as a clear gum.", "LCMS calculated for C16H21N2O4 (M+H-28)+: m/z=305.2; Found: 305.1.Step 6.Benzyl [(1R,2R,5S)-5-amino-2-(cyanomethyl)cyclohexyl]carbamate To a mixture of benzyl [(1R,2R,5S)-5-azido-2-(cyanomethyl)cyclohexyl]carbamate (45 mg, 0.14 mmol) in tetrahydrofuran (1.5 mL) was added water (13 μL, 0.73 mmol) and resin of triphenylphosphine (150 mg, 0.29 mmol).", "The resulting mixture was stirred overnight at room temperature.", "The mixture was filtered and dried in vacuo to give 32 mg of crude product.", "LCMS calculated for C16H22N3O2 (M+H)+: m/z=288.2; Found: 288.0.The crude was used without further purification.", "Step 7.Benzyl {(1R,2R,5S)-2-(cyanomethyl)-5-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}carbamate A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (22.0 mg, 0.102 mmol), benzyl [(1R,2R,5S)-5-amino-2-(cyanomethyl)cyclohexyl]carbamate (32 mg, 0.11 mmol) and triethylamine (35.7 μL, 0.256 mmol) in isopropyl alcohol (0.4 mL) was stirred at 90° C. for 2 h. The mixture was cooled and purified on silica gel, eluted with 10-90% EtOAc in hexanes to give 28 mg (59%) of the desired product.", "LCMS calculated for C23H24N5O4S (M+H)+: m/z=466.2; Found: 466.1.Step 8.Benzyl [(1R,2R,5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-2-(cyanomethyl)cyclohexyl]carbamate A mixture of benzyl {(1R,2R,5S)-2-(cyanomethyl)-5-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}carbamate (28 mg, 0.060 mmol) and 10% palladium on carbon (7.0 mg) in methanol (0.44 mL) was stirred under an atmosphere of H2 (balloon) for 3 h. The mixture was filtered and concentrated to give 26 mg of the desired product.", "LCMS calculated for C23H26N5O2S (M+H)+: m/z=436.2; Found: 436.0.Step 9.Benzyl ((1R,2R,5S)-2-(cyanomethyl)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)carbamate A mixture of (2R)-2-hydroxypropanamide (17.1 mg, 0.192 mmol) and triethyloxonium tetrafluoroborate (34.2 mg, 0.180 mmol) in tetrahydrofuran (0.36 mL) was stirred at room temperature for 75 min and then concentrated.", "The residue was dissolved in ethanol (0.14 mL), and this solution was then added to a solution of benzyl [(1R,2R,5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-2-(cyanomethyl)cyclohexyl]carbamate (26 mg, 0.060 mmol) in ethanol (0.36 mL) in a vial.", "The resulting mixture was stirred at 80° C. overnight.", "After cooling, the mixture was concentrated and purified on silica gel, eluted with 0-10% MeOH in dichloromethane to give 18 mg of the desired product.", "LCMS calculated for C26H28N5O3S (M+H)+: m/z=490.2; Found: 490.0.Step 10.", "((1R,2R,4S)-2-Amino-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile A mixture of benzyl ((1R,2R,5S)-2-(cyanomethyl)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)carbamate (18 mg, 0.037 mmol) and 10% palladium on carbon (24 mg) in methanol (0.27 mL) was stirred under an atmosphere of H2 (balloon) overnight.", "The mixture was filtered and concentrated.", "The crude was purified using prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 3.2 mg of the desired product.", "LCMS calculated for C18H22N5OS (M+H)+: m/z=356.2; Found: 356.1.Example 68.", "{(2R,5S)-5-[2-(1-Aminoethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile trifluoroacetate Step 1.", "[(2R,5S)-5-(2-Acetyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]acetonitrile To a solution of ((2R,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile (154 mg, 0.450 mmol) in methylene chloride (2.0 mL) was added sodium bicarbonate (110 mg, 1.31 mmol) followed by Dess-Martin periodinane (219 mg, 0.517 mmol).", "The resulting mixture was stirred at room temperature for 3 h. The mixture was diluted with dichloromethane, filtered, and concentrated.", "The crude was purified on silica gel, eluted with 0-10% MeOH in dichloromethane to give 250 mg of crude product as a white gum.", "LCMS calculated for C17H7N4O2S (M+H)+: m/z=341.1; Found: 341.0 (M+H).", "1H NMR (400 MHz, CDCl3) δ 9.23 (s, 1H), 7.77 (s, 2H), 4.52 (t, J=11.1 Hz, 1H), 4.07 (dd, J=10.1 and 4.4 Hz, 2H), 2.92-2.81 (m, 3H), 2.70-2.64 (m, 2H), 2.21-2.09 (m, 2H), 1.83 (qd, J=13.4 and 4.7 Hz, 1H), 1.62 (s, 2H) ppm.", "Step 2.", "{(2R,5S)-5-[2-(1-Aminoethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile trifluoroacetate A mixture of [(2R,5S)-5-(2-acetyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)tetrahydro-2H-pyran-2-yl]acetonitrile (0.10 g, 0.18 mmol), ammonium acetate (136 mg, 1.76 mmol) and sodium cyanoborohydride (28 mg, 0.44 mmol) in methanol (0.4 mL)/acetonitrile (0.4 mL) was heated at 65° C. overnight.", "The mixture was cooled and purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 30 mL/min) to give 27 mg (46%) of the desired product.", "LCMS calculated for C17H20N5OS (M+H)+: m/z=342.1; Found: 342.0.Example 69.N-(1-{1-[(3S,6R)-6-(Cyanomethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethyl) acetamide To a mixture of {(2R,5S)-5-[2-(1-aminoethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile trifluoroacetate (8.0 mg, 0.018 mmol) (Example 68) and triethylamine (12 μL, 0.088 mmol) in methylene chloride (0.15 mL) was added acetyl chloride (2.0 μL, 0.028 mmol).", "The resulting mixture was stirred at room temperature for 3 h and then concentrated.", "The residue was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 3.5 mg (52%) of the desired product.", "LCMS calculated for C19H22N5O2S (M+H)+: m/z=384.1; Found: 384.2.Example 70.", "((2R,5S)-5-{2-[1-(Methylamino)ethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)acetonitrile To a cooled mixture of {(2R,5S)-5-[2-(1-hydroxyethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile (10.1 mg, 0.0295 mmol) and triethylamine (12 μL, 0.088 mmol) in methylene chloride (0.18 mL) was added methanesulfonyl chloride (2.7 μL, 0.035 mmol).", "The resulting mixture was allowed to warm to room temperature and stirred overnight.", "The mixture was diluted with dichloromethane and washed with water (2×).", "The layers were separated and the organic concentrated.", "To the concentrate was added methylene chloride (0.2 mL), triethylamine (18 uL), and methylammonium chloride (6.0 mg, 0.088 mmol).", "The resulting mixture was stirred at room temperature over the weekend (64 h) then heated to 40° C. for 3 h. The mixture was concentrated then purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 2 mg (19%) of the desired product.", "LCMS calculated for C18H22N5OS (M+H)+: m/z=356.2; Found: 356.1.Example 71.", "{(2R,5S)-5-[2-(1-Fluoroethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile To a cooled mixture of {(2R,5S)-5-[2-(1-hydroxyethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile (8.0 mg, 0.023 mmol) in methylene chloride (0.2 mL) was added 2-methoxy-N-(2-methoxyethyl)-N-(trifluoro-λ(4)-sulfanyl)ethanamine (4.7 μL, 0.026 mmol) (Deoxo-Fluor).", "The resulting mixture was warmed to room temperature and stirred overnight.", "Additional Deoxo-Fluor (5 uL) was added.", "After 6 h, the reaction was quenched with a few drops of water then concentrated.", "The residue was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 1.6 mg (20%) of the desired product.", "LCMS calculated for C17H18FN4OS (M+H)+: m/z=345.1; Found: 345.0.Example 72.", "[4-(Hydroxymethyl)-4-(1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile Step 1.", "(8-Amino-1,4-dioxaspiro[4.5]dec-8-yl)methanol Lithium tetrahydroaluminate (189 mg, 4.97 mmol) was added in portions to a solution of 8-amino-1,4-dioxaspiro[4.5]decane-8-carboxylic acid (from Aldrich, 0.50 g, 2.5 mmol) in tetrahydrofuran (20 mL) with stirring at about 0° C. The resulting mixture was slowly warmed to room temperature and stirred overnight.", "Fieser workup (0.2 mL H2O, 0.2 mL 10% NaOH, 0.6 mL H2O) was performed followed by filtration through Celite and concentrated to give 0.41 g of the desired product to be used without further purifications.", "LCMS calculated for C9H8NO3 (M+H)+: m/z=188.1; Found: 188.0.Step 2.", "{8-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]-1,4-dioxaspiro[4.5]dec-8-yl}methanol A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (229 mg, 1.07 mmol), (8-amino-1,4-dioxaspiro[4.5]dec-8-yl)methanol (240 mg, 1.28 mmol) and triethylamine (300 μL, 2 mmol) in isopropyl alcohol (3.5 mL) was stirred at 90° C. overnight.", "After cooling to room temperature, water was added, which caused more solids to form.", "The solids were filtered, washed with water, and dried to give 219 mg (56%) of the desired product.", "LCMS calculated for C16H20N3O5S (M+H)+: m/z=366.1; Found: 366.1.1H NMR (300 MHz, CDCl3) δ 8.93 (s, 1H), 7.78-7.75 (m, 2H), 4.17 (s, 2H), 4.02-3.84 (m, 4H), 2.52 (d, J=13.3 Hz, 2H), 2.12-1.82 (m, 4H), 1.78-1.44 (m, 4H) ppm.", "Step 3.", "{8-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]-1,4-dioxaspiro[4.5]dec-8-yl}methanol To a mixture of {8-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]-1,4-dioxaspiro[4.5]dec-8-yl}methanol (219 mg, 0.599 mmol) in methanol (4.5 mL) was added 10% palladium on carbon (76 mg).", "The mixture was stirred under an atmosphere of H2 (balloon) for 2 d. The mixture was filtered through Celite and concentrated to give 0.20 g of the crude product, which was used directly in the next step without further purifications.", "LCMS calculated for C16H22N3O3S (M+H)+: m/z=336.1; Found: 336.2.Step 4.", "[8-(1H-Imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-1,4-dioxaspiro[4.5]dec-8-yl]methanol A mixture of {8-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-1,4-dioxaspiro[4.5]dec-8-yl}methanol (90.0 mg, 0.268 mmol), ethyl orthoformate (112 μL, 0.671 mmol), and p-toluenesulfonic acid monohydrate (5.1 mg, 0.027 mmol) in toluene (3.0 mL) was stirred at 85° C. overnight.", "The mixture was diluted with EtOAc, then washed with sat.", "sodium bicarbonate and brine.", "The organic layer was dried (Na2SO4), filtered and concentrated to give 50 mg (50%) of the desired product.", "LCMS calculated for C17H20N3O3S (M+H)+: m/z=346.1; Found: 346.0.Step 5.4-(Hydroxymethyl)-4-(1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexanone A mixture of [8-(1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)-1,4-dioxaspiro[4.5]dec-8-yl]methanol (0.13 g, 0.38 mmol) and 3.0 M hydrogen chloride in water (2.0 mL, 6.0 mmol) in acetone (5 mL) was stirred at room temperature for 5 h and then at 60° C. for 1 h. After cooling, the mixture was made slightly basic by the addition of 2.0 N NaOH.", "The mixture was extracted with EtOAc (3×).", "The combined extracts were dried (Na2SO4), filtered, and concentrated.", "The crude was purified on silica gel, eluted with 0-15% MeOH in dichloromethane to give 56 mg (49%) of the desired product.", "LCMS calculated for C15H6N3O2S (M+H)+: m/z=302.1; Found: 302.1.Step 6.", "[4-(Hydroxymethyl)-4-(1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexylidene]acetonitrile To a solution of diethyl cyanomethylphosphonate (38.6 mg, 0.218 mmol) in tetrahydrofuran (0.5 mL) stirring at about 0° C. was added sodium hydride (10.5 mg, 0.262 mmol).", "To this was added a solution of 4-(hydroxymethyl)-4-(1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexanone (56 mg, 0.18 mmol) in N,N-dimethylformamide (0.45 mL).", "The mixture was allowed to warm to room temperature and stirred overnight.", "The reaction was quenched with water, causing formation of solids.", "The solids were filtered to give 18 mg of pure desired product.", "The filtrate was diluted with EtOAc, washed with water, and concentrated to give an additional 39 mg of the crude product.", "LCMS calculated for C17H17N4OS (M+H)+: m/z=325.1; Found: 325.0.H NMR (300 MHz, CDCl3) δ 8.37 (s, 1H), 8.15 (s, 1H), 7.47 (d, J=5.6 Hz, 1H), 7.18 (d, J=5.6 Hz, 1H), 5.20 (s, 1H), 4.34 (s, 2H), 2.80 (d, J=4.0 Hz, 3H), 2.59-2.29 (m, 4H), 1.26 (d, J=15.3 Hz, 2H) ppm.", "Step 7.", "[4-(Hydroxymethyl)-4-(1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile A mixture of [4-(hydroxymethyl)-4-(1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexylidene]acetonitrile (18 mg, 0.055 mmol) and 10% palladium on carbon (5.9 mg) in methanol (0.6 mL) was stirred under an atmosphere of H2 (balloon) for 4.5 h. The mixture was filtered through a pad of Celite and concentrated.", "The crude residue was purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give two isomers.", "On analytic HPLC (Waters SunFire C18, 2.1×50 mm, 5 μM; flow rate 3 mL/min; Injection volume 2 μL; at gradient from 2 to 80% B in 3 minutes (A=water with 0.025% TFA, B=acetonitrile)): First peak retention time 1.05 min, LCMS calculated for C17H19N4OS (M+H)+: m/z=327.1; Found: 327.0.Second peak retention time 1.13 min, LCMS calculated for C17H19N4OS (M+H)+: m/z=327.1; Found: 327.0.Example 73.", "{(2R,5S)-5-[2-(Cyanomethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile Step 1.tert-Butyl [(3S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamate {(5S)-5-[(tert-Butoxycarbonyl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate (from example 19, step 5) (3.47 g, 12.8 mmol) and 10% palladium on carbon (1.4 g) in methanol (60 mL) was stirred under a H2 balloon at room temperature for 2 h. The reaction mixture was filtered and the filtrate was treated with 1.0 M sodium hydroxide in water (12 mL).", "After stirring for 4 h, the reaction solution was concentrated and diluted with ethyl acetate.", "The organic layer was separated and washed with brine, dried over Na2SO4, and concentrated.", "The residue was purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (0.77 g, 26%).", "LCMS calculated for C6H14NO2 (M−100+H)+: m/z=132.1; Found: 132.1.Step 2.", "{(5S)-5-[(tert-Butoxycarbonyl)amino]tetrahydro-2H-pyran-2-yl}methyl methanesulfonate tert-Butyl [(3S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamate (331 mg, 1.43 mmol) in dichloromethane (5 mL) was treated with methanesulfonyl chloride (0.222 mL, 2.87 mmol) at 0° C. The mixture was stirred at 0° C. for 1 h, then concentrated and partitioned between ethyl acetate and water.", "The organic phase was concentrated and purified on silica gel (eluting with a gradient of 0 to 50% ethyl acetate in hexanes) to give the desired product (0.38 g, 86%).", "LCMS calculated for C8H16NO6S (M-t-Bu+H)+: m/z=254.1; Found: 254.0.Step 3.", "[(5S)-5-Aminotetrahydro-2H-pyran-2-yl]acetonitrile A mixture of {(5S)-5-[(tert-butoxycarbonyl)amino]tetrahydro-2H-pyran-2-yl}methyl methanesulfonate (308 mg, 0.996 mmol) and sodium cyanide (58 mg, 1.2 mmol) in DMSO (3 mL) was stirred at 90° C. overnight.", "After cooling to room temperature, the mixture was partitioned between ethyl acetate and brine.", "The organic layer was washed with water and brine, dried over Na2SO4, and concentrated to give the cyano intermediate.", "A solution of the intermediate in dichloromethane (4 mL) was treated with 4 M HCl in dioxane (2 mL) and the mixture was stirred at room temperature for 2 h, then concentrated to give the desired product as HCl salt.", "(42 mg, 30%).", "LCMS calculated for C7H13N2O (M+H)+: m/z=141.1; Found: 141.1.Step 4.", "{(2R,5S)-5-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}acetonitrile and {(2S,5S)-5-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}acetonitrile 7-Chloro-6-nitrothieno[3,2-b]pyridine (1.18 g, 5.52 mmol), [(5S)-5-aminotetrahydro-2H-pyran-2-yl]acetonitrile hydrochloride (1.01 g, 5.72 mmol) and N,N-diisopropylethylamine (2.0 mL, 12 mmol) in isopropyl alcohol (13 mL) was heated at 50° C. overnight.", "The solvent was removed and the solid was dissolve in dichloromethane and purified with flash chromatography (20-90% ethyl acetate/hexanes) to give two fractions.", "On the analytical HPLC (Waters SunFire C18, 2.1×50 mm, 5 uM, with injection volume 2 uL and flow rate 3 mL/min, at gradient from 2 to 80% B in 3 minutes (A=water with 0.025% TFA; B=acetonitrile)): First fraction retention time 1.715 min, LCMS calculated for C14H15N4O3S (M+H)+: m/z=319.1; Found: 319.1; Second fraction retention time 1.561 min, LCMS calculated for C14H15N4O3S (M+H)+: m/z=319.1; Found: 319.1.Step 5.", "{(2R,5S)-5-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}acetonitrile {(2R,5S)-5-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}acetonitrile (712 mg, 2.24 mmol) (first fraction from last step) and 10% palladium on carbon (360 mg) in methanol (15 mL) was subjected to balloon pressure of H2 at room temperature for 2 h. The reaction mixture was filtered and concentrated and purified with flash chromatography (15% methanol/dichloromethane) to give the desired product (604 mg, 94%).", "LCMS calculated for C14H17N4OS (M+H)+: m/z=289.1; Found: 289.0.Step 6.", "{(2R,5S)-5-[2-(Cyanomethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile A mixture of 2-cyanoacetamide (80.8 mg, 0.960 mmol) and triethyloxonium tetrafluoroborate (181 mg, 0.952 mmol) in THF (2 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (0.6 mL) and added to a suspension of {(2R,5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}acetonitrile (85.0 mg, 0.295 mmol) in ethanol (2 mL).", "The resulting mixture was stirred at 55° C. overnight.", "The reaction was cooled to room temperature and the solid was filtered.", "The filtrate was purified with preparative LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 60 mL/min) to give the desired product as TFA salt.", "LCMS calculated for C17H16N5OS (M+H)+: m/z=338.1; Found: 338.3.1H NMR (DMSO-d6, 500 MHz) δ 9.24 (s, 1H), 8.22 (d, J=5.5 Hz, 1H), 7.77 (d, J=5.5 Hz, 1H), 4.89 (s, 2H), 4.67 (br s, 1H), 4.20 (m, 2H), 4.00 (s, 1H), 2.96 (dd, J=17.0, 4.3 Hz, 1H), 2.84 (dd, J=17.0, 6.6 Hz, 1H), 2.49 (m, 1H), 2.29 (m, 1H), 2.06 (m, 1H), 1.72 (m, 1H) ppm.", "Example 74.", "{(2S,5S)-5-[2-(Cyanomethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile Step 1.", "{(2S,5S)-5-[(6-Aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}acetonitrile This compound was prepared according to the procedure described in Example 73, Step 5, using {(2S,5S)-5-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}acetonitrile (fraction 2, from Example 73, step 4) instead of {(2R,5S)-5-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}acetonitrile as starting material LCMS calculated for C14H17N4OS (M+H)+: m/z=289.1; Found: 289.0.Step 2.", "{(2S,5S)-5-[2-(Cyanomethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile This compound was prepared according to the procedure described in Example 73, Step 6, using {(2S,5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}acetonitrile instead of {(2R,5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}acetonitrile as starting material.", "LCMS calculated for C17H16N5OS (M+H)+: m/z=338.1; Found: 338.3.Example 75.N-[((2R,5S)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl]methanesulfonamide Step 1.", "(1R)-1-{1-[(3S,6R)-6-(Azidomethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol A mixture of ((2R,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate (25 mg, 0.052 mmol) and sodium azide (5.0 mg, 0.077 mmol) in DMF (0.5 mL) was stirred at 60° C. overnight.", "After cooling to room temperature, the mixture was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give desired product (12 mg, 65%).", "LCMS calculated for C16H19N6O2S (M+H)+: m/z=359.1; Found: 359.0.Step 2.", "(1R)-1-{1-[(3S,6R)-6-(Aminomethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol A solution of (1R)-1-{1-[(3S,6R)-6-(azidomethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol (12 mg, 0.034 mmol) in methanol (0.2 mL) was added 10% palladium on carbon (5.7 mg).", "The resulting mixture was stirred under H2 balloon overnight.", "The reaction mixture was filtered through a pad of Celite and washed with methanol.", "The solvent was removed under reduced pressure to give the desired product (11 mg, 99%).", "LCMS calculated for C16H21N4O2S (M+H)+: m/z=333.1; Found: 333.1.Step 3.N-[((2R,5S)-5-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl]methanesulfonamide To a solution of (1R)-1-{1-[(3S,6R)-6-(aminomethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol (11 mg, 0.033 mmol) in methanol (0.5 mL) was added N,N-diisopropylethylamine (17 μL, 0.099 mmol) and methanesulfonyl chloride (2.8 μL, 0.036 mmol).", "After stirring for 0.5 h, another equivalent of methanesulfonyl chloride was added.", "After stirring for 20 min, The reaction solution was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (5 mg, 37%).", "LCMS calculated for C17H23N4O4S2 (M+H)+: m/z=411.1; Found: 411.1.Example 76.Isopropyl [((2R,5S)-5-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}tetrahydro-2H-pyran-2-yl)methyl]carbamate To a solution of (1R)-1-{1-[(3S,6R)-6-(aminomethyl)tetrahydro-2H-pyran-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol (11 mg, 0.032 mmol) and triethylamine (22 μL, 0.16 mmol) in methylene chloride (1 mL) was added 1.0 M isopropyl chloroformate in toluene (39 μL).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give the desired product (0.9 mg, 7%).", "LCMS calculated for C20H27N4O4S (M+H)+: m/z=419.2; Found: 419.0.Example 77.", "[trans-4-(8-Methylpyrazolo[1,5-c]thieno[2,3-e]pyrimidin-9-yl)cyclohexyl]acetonitrile Step 1.4-(Hydroxymethyl)cyclohexanol To a suspension of lithium tetrahydroaluminate (3.11 g, 81.9 mmol) in THF (158 mL) was added a solution of ethyl 4-hydroxycyclohexanecarboxylate (9.40 g, 54.6 mmol) in THF (20 mL) at 0° C. After stirring for 30 min at same temperature, the reaction was quenched with water (10 mL) dropwise, then 15% NaOH solution (10 mL) and water (30 mL).", "After stirring for 10 min, the reaction mixture was filtered through a pad of Celite, the organic layer was wash with brine, dried over Na2SO4, filtered and concentrated in vacuo.", "The residue was purified by flash chromatography (0-100% ethyl acetate/hex) to give the desired product as white solid (6.9 g, 97%).", "Step 2.", "(cis-4-Hydroxycyclohexyl)methyl 4-methylbenzenesulfonate and (trans-4-Hydroxycyclohexyl)methyl 4-methylbenzenesulfonate To a solution of 4-(hydroxymethyl)cyclohexanol (6.80 g, 52.2 mmol) in dichloromethane (400 mL) and pyridine (10.6 mL, 130 mmol) was added p-toluenesulfonyl chloride (11.0 g, 57.4 mmol) and 4-dimethylaminopyridine (410 mg, 3.3 mmol).", "The reaction mixture was stirred at room temperature overnight.", "The reaction mixture was diluted with 1 N HCl solution and extracted with dichloromethane.", "The combined organics were dried over Na2SO4, filtered and concentrated.", "The crude was purified with flash chromatography (eluting with a gradient 0-50% ethyl acetate in hexanes) to give two fractions.", "On the analytical HPLC (Waters SunFire C18, 2.1×50 mm, 5 uM, with injection volume 2 uL and flow rate 3 mL/min, at gradient from 2 to 80% B in 3 minutes (A=water with 0.025% TFA; B=acetonitrile)): First fraction retention time 2.319 min, LCMS calculated for C14H21O4S (M+H)+: m/z=285.1; Found: 285.0; 1H NMR 1H NMR (300 MHz, CDCl3) δ 7.77 (d, J=8.3 Hz, 1H), 7.33 (d, J=8.1 Hz, 1H), 3.97 (br s, 1H), 3.83 (d, J=6.8 Hz, 2H), 2.44 (s, 3H), 1.76-1.58 (m, 6H), 1.48 (m, 3H) ppm.", "Second fraction retention time 2.222 min, LCMS calculated for C14H21O4S (M+H)+: m/z=285.1; Found: 285.0.1H NMR (300 MHz, CDCl3) δ 7.77 (d, J=8.3 Hz, 2H), 7.45 (d, J=8.3 Hz, 2H), 3.82 (d, J=6.4 Hz, 2H), 3.51 (m, 1H), 2.50 (d, J=8.0 Hz, 0H), 2.44 (s, 3H), 2.14-1.90 (m, 2H), 1.80-1.52 (m, 3H), 1.45-1.09 (m, 2H), 1.09-0.87 (m, 2H) ppm.", "Step 3.", "(cis-4-Hydroxycyclohexyl)acetonitrile A mixture of (cis-4-hydroxycyclohexyl)methyl 4-methylbenzenesulfonate (6.9 g, 24 mmol) (first fraction from last step), sodium cyanide (1.43 g, 29.1 mmol) and DMF (86 mL) was stirred at 80° C. for 1 h. After cooling to room temperature, the mixture was diluted with ethyl acetate and water.", "The aqueous layer was extracted with ethyl acetate once.", "The combined organic layers were dried over Na2SO4 and concentrated.", "The crude was purified with flash chromatography (eluting with a gradient of 0-50% ethyl acetate in hexanes) to give the desired product (2.5 g, 74%).", "1H NMR (300 MHz, CDCl3) δ 3.58 (m, 1H), 2.27 (d, J=6.3 Hz, 2H), 2.02 (m, 2H), 1.88 (m, 2H), 1.78-1.45 (m, 2H), 1.42-1.07 (m, 4H) ppm.", "Step.", "4.", "(trans-4-Iodocyclohexyl)acetonitrile To a solution of (cis-4-hydroxycyclohexyl)acetonitrile (2.50 g, 18.0 mmol) in dichloromethane (80 mL) at 0° C. was added 1H-imidazole (1.47 g, 21.6 mmol), triphenylphosphine (5.65 g, 21.6 mmol), and followed by iodine (5.47 g, 21.6 mmol) in several portions over a period of 45 min.", "The resulting suspension was gradually allowed to warm to room temperature.", "After stirring at room temperature overnight, the mixture was partitioned between Et2O (100 mL) and water (100 mL).", "The organic layer was washed with saturated Na2SO3 solution and brine, dried over MgSO4, filtered and concentrated.", "The residue was purified by flash chromatography (0-20% ethyl acetate/hexanes) to give the desired product as white solid (1.0 g, 22%).", "H NMR (400 MHz, CDCl3) δ 4.04 (m, 1H), 2.50-2.38 (m, 2H), 2.24 (d, J=6.1 Hz, 2H), 1.99 (m, 2H), 1.77 (m, 3H), 1.22 (m, 2H) ppm.", "Step 5.", "[trans-4-(8-Methylpyrazolo[1,5-c]thieno[2,3-e]pyrimidin-9-yl)cyclohexyl]acetonitrile A microwave tube equipped with a magnetic stir bar and a rubber septum was charged with lithium chloride (44.9 mg, 1.06 mmol).", "The vial was heated at 140° C. for 10 min under high vacuum and backfilled with nitrogen after cooling to room temperature.", "Zinc (69.3 mg, 1.06 mmol) was added and the vial was heated at 140° C. for 10 min under high vacuum and backfilled with nitrogen.", "After cooling to room temperature, THF (0.6 mL) and 1,2-dibromoethane (3.4 μL, 0.040 mmol) was added via syringe.", "The mixture was heated at 60° C. for 10 min and then cooled to room temperature.", "Chlorotrimethylsilane (0.99 μL, 0.0078 mmol) and iodine (1.0 mg, 0.0039 mmol) in THF (0.2 mL) was added and stirred at 60° C. for 10 min and cooled to room temperature.", "(trans-4-Iodocyclohexyl)acetonitrile (132 mg, 0.53 mmol) in THF (0.2 mL) was then added, and the mixture stirred at 50° C. overnight.", "9-Bromo-8-methylpyrazolo[1,5-c]thieno[2,3-e]pyrimidine (80.2 mg, 0.299 mmol), 2-(dicyclohexylphosphino)-2′,6′-dimethoxy-1,1′-biphenyl (29 mg, 0.072 mmol) in toluene (0.2 mL) were added to a microwave vial.", "The vial was evacuated under high vacuum and backfilled with nitrogen.", "The mixture was cooled to 0° C. and the zinc reagent was added slowly via syringe.", "After addition, the reaction was heated to 60° C. overnight and partitioned between EtOAc and saturated NH4Cl solution.", "The layers were separated and the aqueous extracted further with ethyl acetate (2×).", "The combined organics were washed with water and brine, dried over MgSO4, and concentrated.", "The residue was dissolved in methanol and purified with preparative LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give a colorless solid (5.3 mg, 5.7%).", "LCMS calculated for C17H19N4S (M+H)+: m/z=311.1; Found: 311.1.1H NMR (500 MHz, CDCl3) δ 8.96 (s, 1H), 7.59 (m, 1H), 7.49 (m, 1H), 2.90 (m, 1H), 2.51 (s, 3H), 2.36 (d, J=6.5 Hz, 2H), 2.06 (m, 2H), 1.97-1.88 (m, 5H), 1.37 (m, 2H).", "ppm.", "Example 78.Methyl [(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]carbamate Step 1.tert-Butyl ({trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methyl)carbamate A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (220 mg, 1.0 mmol), tert-butyl [(trans-4-aminocyclohexyl)methyl]carbamate (250 mg, 1.1 mmol) and triethylamine (0.43 mL, 3.1 mmol) in isopropyl alcohol (8 mL) was heated at 90° C. for 2 h. The solvent was removed and the resulting residue was purified by flash chromatography (0-80% EtOAc/Hexanes) to give the desired product (0.32 g, 77%).", "LCMS calculated for C19H27N4O4S (M+H)+: m/z=407.2; Found: 407.0.Step 2.tert-Butyl ({trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methyl)carbamate A mixture of tert-butyl ({trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methyl)carbamate (0.32 g, 0.79 mmol) and 10% palladium on carbon (0.01 g) in methanol (3 mL) was hydrogenated under balloon pressure of hydrogen at room temperature for 2 h. The mixture was filtered and concentrated to give the desired product (0.3 g, 100%) to be used in the next step directly.", "LCMS calculated for C19H29N4O2S (M+H)+: m/z=377.2; Found: 377.1.Step 3.tert-Butyl [(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]carbamate A mixture of (2R)-2-hydroxypropanamide (0.29 g, 3.3 mmol) and triethyloxonium tetrafluoroborate (0.61 g, 3.2 mmol) in THF (5.6 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (2.4 mL) and added to a suspension of tert-butyl ({trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methyl)carbamate (0.30 g, 0.80 mmol) in ethanol (8.6 mL).", "The mixture was stirred at 85° C. for 2 h. The mixture was concentrated and purified with flash chromatography (0-10% methanol/dichloromethane) to give the desired product (0.21 g, 61%).", "LCMS calculated for C22H31N4O3S (M+H)+: m/z=431.2; Found: 431.1.Step 4.", "(1R)-1-{1-[trans-4-(Aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate) (salt) [(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]carbamate (0.21 g, 0.49 mmol) was treated with trifluoroacetic acid (0.7 mL, 9 mmol) in dichloromethane (2 mL) at room temperature for 1 h. The mixture was stripped to dryness to give the desired product as TFA salt (0.35 g, 79%).", "LCMS calculated for C17H23N4OS (M+H)+: m/z=331.1; Found: 331.0.Step 5.Methyl [(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]carbamate To a solution of (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate) (16 mg, 0.029 mmol) and triethylamine (20 μL, 0.14 mmol) in methylene chloride (1 mL) was added methyl chloroformate (2.6 μL, 0.034 mmol).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (1.4 mg, 13%).", "LCMS calculated for C19H25N4O3S (M+H)+: m/z=389.2; Found: 389.0.1H NMR (DMSO-d6, 500 MHz): δ 8.98 (1H, s), 8.02 (1H, d, J=5.5 Hz), 7.66 (1H, d, J=5.5 Hz), 7.24 (1H, m), 5.80 (1H, br s), 5.18 (1H, m), 4.90 (1H, br s), 3.54 (3H, s), 2.96 (2H, m), 2.38 (2H, m), 2.00-1.93 (4H, m), 1.76 (1H, m), 1.65 (3H, d, J=6.5 Hz), 1.21 (2H, m) ppm.", "Example 79.N-[(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]acetamide To a solution of (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate) (16 mg, 0.029 mmol) and triethylamine (20.μL, 0.14 mmol) in dichloromethane (1 mL) was added acetic anhydride (4.0 μL, 0.043 mmol).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (1.4 mg, 13%).", "LCMS calculated for Cl9H25N4O2S (M+H)+: m/z=373.2; Found: 373.1.Example 80.N-[(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]methanesulfonamide To a solution of (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate) (16 mg, 0.029 mmol) and triethylamine (20.L, 0.14 mmol in methylene chloride (1 mL) was added methanesulfonyl chloride (2.7 μL, 0.034 mmol).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 60 mL/min) to give the desired compound as TFA salt (1.9 mg, 16%) as TFA salt.", "LCMS calculated for C18H25N4O3S2 (M+H)+: m/z=409.1; Found: 409.1.Example 81.N′-[(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]-N,N-dimethylurea To a solution of (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate) (16 mg, 0.029 mmol) and triethylamine (20 μL, 0.14 mmol) in methylene chloride (1 mL) was added N,N-dimethylcarbamoyl chloride (3.2 μL, 0.034 mmol).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 60 mL/min) to give the desired compound as TFA salt (3.4 mg, 30%) as TFA salt.", "LCMS calculated for C20H28N5O2S (M+H)+: m/z=402.2; Found: 402.2.Example 82.Ethyl [(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]carbamate To a solution of (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate) (18 mg, 0.032 mmol) and triethylamine (22 μL, 0.16 mmol) in methylene chloride (1 mL) was added ethyl chloroformate (3.7 μL, 0.039 mmol).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (0.9 mg, 7%).", "LCMS calculated for C20H27N4O3S (M+H)+: m/z=403.2; Found: 402.9.Example 83.Propyl [(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]carbamate To a solution of (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate) (18 mg, 0.032 mmol) and triethylamine (22 μL, 0.16 mmol) in methylene chloride (1 mL) was added propyl chloroformate (4.3 μL, 0.039 mmol).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (0.9 mg, 7%).", "LCMS calculated for C21H29N4O3S (M+H)+: m/z=417.2; Found: 417.0.Example 84.Isopropyl [(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]carbamate To a solution of (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate) (18 mg, 0.032 mmol) and triethylamine (22 μL, 0.16 mmol) in methylene chloride (1 mL) was added 1.0 M isopropyl chloroformate in toluene (39 μL).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (0.9 mg, 7%).", "LCMS calculated for C21H29N4O3S (M+H)+: m/z=417.2; Found: 417.1.Example 85.Tetrahydrofuran-3-yl [(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]carbamate To a solution of (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate) (18 mg, 0.032 mmol) and triethylamine (22 μL, 0.16 mmol) in methylene chloride (1 mL) was added 4-nitrophenyl tetrahydrofuran-3-yl carbonate (9.8 mg, 0.039 mmol).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (1.8 mg, 12%).", "LCMS calculated for C22H29N4O4S (M+H)+: m/z=445.2; Found: 445.0.Example 86.Methyl ({trans-4-[2-(cyanomethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}methyl)carbamate Step 1.tert-Butyl ({trans-4-[2-(cyanomethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}methyl) carbamate A mixture of 2-cyanoacetamide (120 mg, 1.5 mmol) and triethyloxonium tetrafluoroborate (270 mg, 1.4 mmol) in THF (1.1 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (0.5 mL) and added to a suspension of tert-butyl ({trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methyl)carbamate (150 mg, 0.40 mmol) in ethanol (1.7 mL).", "The mixture was stirred at 85° C. for 2 h. The solid was filtered and the filtrate was concentrated and purified on flash chromatography (0-10% methanol/dichloromethane) to give the desired product (0.12 g, 71%).", "LCMS calculated for C22H28N5O2S (M+H)+: m/z=426.2; Found: 426.0.Step 2.", "{1-[trans-4-(Aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile bis(HCl) ({trans-4-[2-(Cyanomethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}methyl)carbamate (0.12 g, 0.28 mmol)) was treated with 4.0 M hydrogen chloride in dioxane (0.5 mL) in methylene chloride (0.5 mL) at room temperature for 1 h. The solid was filtered, washed with DCM and methanol, and air-dried to give the desired product (0.10 g, 77%).", "LCMS calculated for C17H20N5S (M+H)+: m/z=326.1; Found: 326.0.Step 3.Methyl ({trans-4-[2-(cyanomethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}methyl) carbamate To a solution of {1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile (9.5 mg, 0.029 mmol) and triethylamine (20 μL, 0.14 mmol) in methylene chloride (1 mL) was added methyl chloroformate (2.7 μL, 0.035 mmol).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (1.4 mg, 12%).", "LCMS calculated for C19H22N5O2S (M+H)+: m/z=384.1; Found: 384.0.Example 87.Ethyl ({trans-4-[2-(cyanomethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}methyl)carbamate To a solution of {1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile (9.5 mg, 0.029 mmol) and triethylamine (20.μL, 0.14 mmol) in methylene chloride (1 mL) was added ethyl chloroformate (3.3 μL, 0.035 mmol).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (1.9 mg, 16%).", "LCMS calculated for C20H24N5O2S (M+H)+: m/z=398.2; Found: 397.8.Example 88.Isopropyl ({trans-4-[2-(cyanomethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}methyl)carbamate To a solution of {1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile (9.5 mg, 0.029 mmol) and triethylamine (20.μL, 0.14 mmol) in methylene chloride (1 mL) was added 1.0 M isopropyl chloroformate in toluene (35 μL).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (1.5 mg, 12%).", "LCMS calculated for C21H26N5O2S (M+H)+: m/z=412.2; Found: 412.1.Example 89.N-({trans-4-[2-(Cyanomethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}methyl)propanamide To a solution of {1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile (9.5 mg, 0.029 mmol) and triethylamine (20.μL, 0.14 mmol) in methylene chloride (1 mL) was added propanoyl chloride (3.0 μL, 0.035 mmol).", "The mixture was stirred at room temperature for 1 h, then stripped to dryness and purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (1.1 mg, 9.9%).", "LCMS calculated for C20H24N5OS (M+H)+: m/z=382.2; Found: 382.1.Example 90.", "{1-[trans-4-(Cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile A mixture of 2-cyanoacetamide (11 mg, 0.13 mmol) and triethyloxonium tetrafluoroborate (21 mg, 0.11 mmol) in THF (0.13 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (55 μL) and added to a suspension of {trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile (8.9 mg, 0.031 mmol) in ethanol (0.20 mL).", "The mixture was stirred at 85° C. for 2 h. The mixture was purified on prep-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 60 mL/min) to give the desired product (2.7 mg, 26%) as TFA salt.", "LCMS calculated for C18H18N5S (M+H)+: m/z=336.1; Found: 336.0.Example 91.", "{(2R,5S)-5-[2-(Hydroxymethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]tetrahydro-2H-pyran-2-yl}acetonitrile A mixture of 2-hydroxyacetamide (93.3 mg, 1.24 mmol) and triethyloxonium tetrafluoroborate (234 mg, 1.23 mmol) in THF (2 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue dissolved in ethanol (0.7 mL) and added to a suspension of {(5S)-5-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]tetrahydro-2H-pyran-2-yl}acetonitrile (101 mg, 0.350 mmol) in ethanol (2.6 mL).", "The reaction mixture was stirred at 80° C. for 1 h, and then cooled to room temperature.", "The solid was filtered off.", "The filtrate was diluted with methanol and purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 60 mL/min) to give the desired product (40 mg, 35%).", "LCMS calculated for C16H17N4O2S (M+H)+: m/z=329.1; Found: 329.1.1H NMR (DMSO-d6, 500 MHz) δ 8.98 (s, 1H), 8.04 (d, J=5.5 Hz, 1H), 7.69 (d, J=5.5 Hz, 1H), 5.89 (s, 1H), 4.92 (m, 1H), 4.87 (s, 2H), 4.28 (m, 1H), 4.18-4.11 (m, 1H), 3.98 (m, 1H), 2.95 (dd, J=17.0, 4.3 Hz, 1H), 2.83 (dd, J=17.0, 6.6 Hz, 1H), 2.64 (m, 1H), 2.49 (m, 1H), 2.22 (m, 1H), 2.06 (m, 1H) ppm.", "Example A: In Vitro JAK Kinase Assay Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Biochemistry 1999, 269, 94-104.The catalytic domains of human JAK1 (a.a. 837-1142), JAK2 (a.a. 828-1132) and JAK3 (a.a. 781-1124) were expressed using baculovirus in insect cells and purified.", "The catalytic activity of JAK1, JAK2 or JAK3 was assayed by measuring the phosphorylation of a biotinylated peptide.", "The phosphorylated peptide was detected by homogenous time resolved fluorescence (HTRF).", "IC50s of compounds were measured for each kinase in the 40 μL reactions that contain the enzyme, ATP and 500 nM peptide in 50 mM Tris (pH 7.8) buffer with 100 mM NaCl, 5 mM DTT, and 0.1 mg/mL (0.01%) BSA.", "For the 1 mM IC50 measurements, ATP concentration in the reactions was 1 mM.", "Reactions were carried out at room temperature for 1 hour and then stopped with 20 μL 45 mM EDTA, 300 nM SA-APC, 6 nM Eu-Py20 in assay buffer (Perkin Elmer, Boston, Mass.).", "Binding to the Europium labeled antibody took place for 40 minutes and HTRF signal was measured on a PHERA star plate reader (BMG, Cary, N.C.).", "The Example compounds were each tested in the Example A assay (see Table 1 for data for the compounds of the examples as tested by the assay of Example A at 1 mM ATP).", "TABLE 1 JAK1 JAK2 Example IC50 (nM) IC50 (nM) JAK2/JAK1 1 ++ +++++ >3 2 + ++ >10 3 ++ +++++ >10 4 + +++ >10 5 + +++++ >10 6 +++ +++++ >6 7 + +++ >10 8 + ++ >10 9 (1st peak) +++++ +++++ 9 (2nd peak) ++ +++++ >10 10 + ++ >10 11 + +++++ >10 12 + +++ >10 13 + ++++ >10 14 ++ +++++ >5 15 +++ +++++ >9 16 ++ ++++ >10 17 + ++ >10 18 + ++ >10 19 ++ +++++ >10 20 + ++ >10 21 ++ +++++ >10 22 ++ +++++ >4 23 + ++ >10 24 (first peak) + ++++ >10 24 (second peak) ++ ++++ >10 25 + ++ >6 26 + ++ >10 27 + ++ >10 28 +++ +++++ >7 29 ++ +++ >9 30 (first peak) ++ ++++ >2 30 (second peak) +++ +++++ >10 31 ++ +++++ >10 32 + ++++ >10 33 + ++ >7 34 ++ +++ >10 35 + ++++ >10 36 (first peak) + ++++ >10 36 (second peak) + ++ >10 37 (first peak) ++ +++++ >10 37 (second peak) + ++ >10 38 + + >10 39 + ++ >10 40 (first peak) + ++ >10 40 (second peak) ++++ +++++ 41 (first peak) + ++ >10 41 (second peak) ++++ +++++ 42 + ++ >10 43 + ++ >10 44 ++ +++++ >10 45 + ++++ >10 46 + ++ >3 47 + ++ >10 48 + + >7 49 ++ +++++ >10 50 ++ +++++ >10 51 ++ ++++ >10 52 ++ +++++ >10 53 ++ +++++ >10 54 ++ +++++ >10 55 ++ +++++ >10 56 ++ +++++ >10 57 + ++++ >10 58 + +++++ >10 59 ++ +++++ >10 60 ++ +++++ >10 61 ++ +++++ >10 62 ++ ++++ >10 63 +++ +++++ >6 64 + +++++ >10 65 ++ +++++ >10 66 ++ +++++ >10 67 ++ ++++ >10 68 + +++ >10 69 ++ +++++ >10 70 ++ ++++ >10 71 + ++ >10 72 (second peak) + ++ >5 73 + ++ >10 74 ++ +++++ >10 75 + +++ >10 76 + +++ >10 77 + + >5 78 + ++ >10 79 + +++ >10 80 + +++ >10 81 + ++++ >10 82 + ++ >10 83 + ++ >10 84 + ++ >10 85 + +++++ >10 86 + ++ >10 87 + ++ >10 88 + +++++ >10 89 + ++++ >10 90 + ++ >10 91 + ++ >10 + indicates an IC50 of ≤100 nM ++ indicates an IC50 of ≤1000 nM +++ indicates an IC50 of ≤2000 nM ++++ indicates an IC50 of >2000 nM +++++ indicates that the IC50 was greater than the highest concentration tested Example B: Cellular Assays Cancer cell lines dependent on cytokines and hence JAK/STAT signal transduction, for growth, can be plated at 6000 cells per well (96 well plate format) in RPMI 1640, 10% FBS, and 1 nG/mL of appropriate cytokine.", "Compounds can be added to the cells in DMSO/media (final concentration 0.2% DMSO) and incubated for 72 hours at 37° C., 5% CO2.The effect of compound on cell viability is assessed using the CellTiter-Glo Luminescent Cell Viability Assay (Promega) followed by TopCount (Perkin Elmer, Boston, Mass.)", "quantitation.", "Potential off-target effects of compounds are measured in parallel using a non-JAK driven cell line with the same assay readout.", "All experiments are typically performed in duplicate.", "The above cell lines can also be used to examine the effects of compounds on phosphorylation of JAK kinases or potential downstream substrates such as STAT proteins, Akt, Shp2, or Erk.", "These experiments can be performed following an overnight cytokine starvation, followed by a brief preincubation with compound (2 hours or less) and cytokine stimulation of approximately 1 hour or less.", "Proteins are then extracted from cells and analyzed by techniques familiar to those schooled in the art including Western blotting or ELISAs using antibodies that can differentiate between phosphorylated and total protein.", "These experiments can utilize normal or cancer cells to investigate the activity of compounds on tumor cell survival biology or on mediators of inflammatory disease.", "For example, with regards to the latter, cytokines such as IL-6, IL-12, IL-23, or IFN can be used to stimulate JAK activation resulting in phosphorylation of STAT protein(s) and potentially in transcriptional profiles (assessed by array or qPCR technology) or production and/or secretion of proteins, such as IL-17.The ability of compounds to inhibit these cytokine mediated effects can be measured using techniques common to those schooled in the art.", "To assess compound effects on JAK2, primary cells or cell lines can be stimulated with JAK2-dependent growth factors such as GM-CSF or Tpo, proteins extracted from cells and analyzed by techniques familiar to those schooled in the art including Western blotting or ELISAs using antibodies that can differentiate between phosphorylated and total protein.", "Compounds herein can also be tested in cellular models designed to evaluate their potency and activity against mutant JAKs, for example, the JAK2V617F mutation found in myeloid proliferative disorders.", "These experiments often utilize cytokine dependent cells of hematological lineage (e.g.", "BaF/3) into which the wild-type or mutant JAK kinases are ectopically expressed (James, C., et al.", "Nature 434:1144-1148; Staerk, J., et al.", "JBC 280:41893-41899).", "Endpoints include the effects of compounds on cell survival, proliferation, and phosphorylated JAK, STAT, Akt, or Erk proteins.", "Certain compounds herein can be evaluated for their activity inhibiting T-cell proliferation.", "Such as assay can be considered a second cytokine (i.e.", "JAK) driven proliferation assay and also a simplistic assay of immune suppression or inhibition of immune activation.", "The following is a brief outline of how such experiments can be performed.", "Peripheral blood mononuclear cells (PBMCs) are prepared from human whole blood samples using Ficoll Hypaque separation method and T-cells (fraction 2000) can be obtained from PBMCs by elutriation.", "Freshly isolated human T-cells can be maintained in culture medium (RPMI 1640 supplemented with 10% fetal bovine serum, 100 U/ml penicillin, 100 μg/ml streptomycin) at a density of 2×106 cells/ml at 37° C. for up to 2 days.", "For IL-2 stimulated cell proliferation analysis, T-cells are first treated with Phytohemagglutinin (PHA) at a final concentration of 10 μg/mL for 72 hours.", "After washing once with PBS, 6000 cells/well are plated in 96-well plates and treated with compounds at different concentrations in the culture medium in the presence of 100 U/mL human IL-2 (ProSpec-Tany TechnoGene; Rehovot, Israel).", "The plates are incubated at 37° C. for 72 h and the proliferation index is assessed using CellTiter-Glo Luminescent reagents following the manufactory suggested protocol (Promega; Madison, Wis.).", "Example C: In Vivo Anti-Tumor Efficacy Compounds herein can be evaluated in human tumor xenograft models in immune compromised mice.", "For example, a tumorigenic variant of the INA-6 plasmacytoma cell line can be used to inoculate SCID mice subcutaneously (Burger, R., et al.", "Hematol J.", "2:42-53, 2001).", "Tumor bearing animals can then be randomized into drug or vehicle treatment groups and different doses of compounds can be administered by any number of the usual routes including oral, i.p., or continuous infusion using implantable pumps.", "Tumor growth is followed over time using calipers.", "Further, tumor samples can be harvested at any time after the initiation of treatment for analysis as described above (Example B) to evaluate compound effects on JAK activity and downstream signaling pathways.", "In addition, selectivity of the compound(s) can be assessed using xenograft tumor models that are driven by other know kinases (e.g.", "Bcr-Abl) such as the K562 tumor model.", "Example D: Murine Skin Contact Delayed Hypersensitivity Response Test Compounds herein can also be tested for their efficacies (of inhibiting JAK targets) in the T-cell driven murine delayed hypersensitivity test model.", "The murine skin contact delayed-type hypersensitivity (DTH) response is considered to be a valid model of clinical contact dermatitis, and other T-lymphocyte mediated immune disorders of the skin, such as psoriasis (Immunol Today.", "1998 January; 19(1):37-44).", "Murine DTH shares multiple characteristics with psoriasis, including the immune infiltrate, the accompanying increase in inflammatory cytokines, and keratinocyte hyperproliferation.", "Furthermore, many classes of agents that are efficacious in treating psoriasis in the clinic are also effective inhibitors of the DTH response in mice (Agents Actions.", "1993 January; 38(1-2):116-21).", "On Day 0 and 1, Balb/c mice are sensitized with a topical application, to their shaved abdomen with the antigen 2,4,dinitro-fluorobenzene (DNFB).", "On day 5, ears are measured for thickness using an engineer's micrometer.", "This measurement is recorded and used as a baseline.", "Both of the animals' ears are then challenged by a topical application of DNFB in a total of 20 μL (10 μL on the internal pinna and 10 μL on the external pinna) at a concentration of 0.2%.", "Twenty-four to seventy-two hours after the challenge, ears are measured again.", "Treatment with the test compounds is given throughout the sensitization and challenge phases (day −1 to day 7) or prior to and throughout the challenge phase (usually afternoon of day 4 to day 7).", "Treatment of the test compounds (in different concentration) is administered either systemically or topically (topical application of the treatment to the ears).", "Efficacies of the test compounds are indicated by a reduction in ear swelling comparing to the situation without the treatment.", "Compounds causing a reduction of 20% or more were considered efficacious.", "In some experiments, the mice are challenged but not sensitized (negative control).", "The inhibitive effect (inhibiting activation of the JAK-STAT pathways) of the test compounds can be confirmed by immunohistochemical analysis.", "Activation of the JAK-STAT pathway(s) results in the formation and translocation of functional transcription factors.", "Further, the influx of immune cells and the increased proliferation of keratinocytes should also provide unique expression profile changes in the ear that can be investigated and quantified.", "Formalin fixed and paraffin embedded ear sections (harvested after the challenge phase in the DTH model) are subjected to immunohistochemical analysis using an antibody that specifically interacts with phosphorylated STAT3 (clone 58E12, Cell Signaling Technologies).", "The mouse ears are treated with test compounds, vehicle, or dexamethasone (a clinically efficacious treatment for psoriasis), or without any treatment, in the DTH model for comparisons.", "Test compounds and the dexamethasone can produce similar transcriptional changes both qualitatively and quantitatively, and both the test compounds and dexamethasone can reduce the number of infiltrating cells.", "Both systemically and topical administration of the test compounds can produce inhibitive effects, i.e., reduction in the number of infiltrating cells and inhibition of the transcriptional changes.", "Example E: In Vivo Anti-Inflammatory Activity Compounds herein can be evaluated in rodent or non-rodent models designed to replicate a single or complex inflammation response.", "For instance, rodent models of arthritis can be used to evaluate the therapeutic potential of compounds dosed preventatively or therapeutically.", "These models include but are not limited to mouse or rat collagen-induced arthritis, rat adjuvant-induced arthritis, and collagen antibody-induced arthritis.", "Autoimmune diseases including, but not limited to, multiple sclerosis, type I-diabetes mellitus, uveoretinitis, thyroditis, myasthenia gravis, immunoglobulin nephropathies, myocarditis, airway sensitization (asthma), lupus, or colitis may also be used to evaluate the therapeutic potential of compounds herein.", "These models are well established in the research community and are familiar to those schooled in the art (Current Protocols in Immunology, Vol 3., Coligan, J. E. et al, Wiley Press.", "; Methods in Molecular Biology: Vol.", "225, Inflammation Protocols., Winyard, P. G. and Willoughby, D. A., Humana Press, 2003.).", "Example F: Animal Models for the Treatment of Dry Eye, Uveitis, and Conjunctivitis Agents may be evaluated in one or more preclinical models of dry eye known to those schooled in the art including, but not limited to, the rabbit concanavalin A (ConA) lacrimal gland model, the scopolamine mouse model (subcutaneous or transdermal), the Botulinumn mouse lacrimal gland model, or any of a number of spontaneous rodent auto-immune models that result in ocular gland dysfunction (e.g.", "NOD-SCID, MRL/lpr, or NZB/NZW) (Barabino et al., Experimental Eye Research 2004, 79, 613-621 and Schrader et al., Developmental Opthalmology, Karger 2008, 41, 298-312, each of which is incorporated herein by reference in its entirety).", "Endpoints in these models may include histopathology of the ocular glands and eye (cornea, etc.)", "and possibly the classic Schirmer test or modified versions thereof (Barabino et al.)", "which measure tear production.", "Activity may be assessed by dosing via multiple routes of administration (e.g.", "systemic or topical) which may begin prior to or after measurable disease exists.", "Agents may be evaluated in one or more preclinical models of uveitis known to those schooled in the art.", "These include, but are not limited to, models of experimental autoimmune uveitis (EAU) and endotoxin induced uveitis (EIU).", "EAU experiments may be performed in the rabbit, rat, or mouse and may involve passive or activate immunization.", "For instance, any of a number or retinal antigens may be used to sensitize animals to a relevant immunogen after which animals may be challenged ocuarly with the same antigen.", "The EIU model is more acute and involves local or systemic administration of lipopolysaccaride at sublethal doses.", "Endpoints for both the EIU and EAU models may include fundoscopic exam, histopathology amongst others.", "These models are reviewed by Smith et al.", "(Immunology and Cell Biology 1998, 76, 497-512, which is incorporated herein by reference in its entirety).", "Activity is assessed by dosing via multiple routes of administration (e.g.", "systemic or topical) which may begin prior to or after measurable disease exists.", "Some models listed above may also develop scleritis/episcleritis, chorioditis, cyclitis, or iritis and are therefore useful in investigating the potential activity of compounds for the therapeutic treatment of these diseases.", "Agents may also be evaluated in one or more preclinical models of conjunctivitis known those schooled in the art.", "These include, but are not limited to, rodent models utilizing guinea-pig, rat, or mouse.", "The guinea-pig models include those utilizing active or passive immunization and/or immune challenge protocols with antigens such as ovalbumin or ragweed (reviewed in Groneberg, D. A., et al., Allergy 2003, 58, 1101-1113, which is incorporated herein by reference in its entirety).", "Rat and mouse models are similar in general design to those in the guinea-pig (also reviewed by Groneberg).", "Activity may be assessed by dosing via multiple routes of administration (e.g.", "systemic or topical) which may begin prior to or after measurable disease exists.", "Endpoints for such studies may include, for example, histological, immunological, biochemical, or molecular analysis of ocular tissues such as the conjunctiva.", "Example G: In Vivo Protection of Bone Compounds may be evaluated in various preclinical models of osteopenia, osteoporosis, or bone resorption known to those schooled in the art.", "For example, ovariectomized rodents may be used to evaluate the ability of compounds to affect signs and markers of bone remodeling and/or density (W. S. S. Jee and W. Yao, J Musculoskel.", "Nueron.", "Interact., 2001, 1(3), 193-207, which is incorporated herein by reference in its entirety).", "Alternatively, bone density and architecture may be evaluated in control or compound treated rodents in models of therapy (e.g.", "glucocorticoid) induced osteopenia (Yao, et al.", "Arthritis and Rheumatism, 2008, 58(6), 3485-3497; and id.", "58(11), 1674-1686, both of which are incorporated herein by reference in its entirety).", "In addition, the effects of compounds on bone resorption and density may be evaluable in the rodent models of arthritis discussed above (Example E).", "Endpoints for all these models may vary but often include histological and radiological assessments as well as immunohisotology and appropriate biochemical markers of bone remodeling.", "Various modifications of the invention, in addition to those described herein, will be apparent to those skilled in the art from the foregoing description.", "Such modifications are also intended to fall within the scope of the appended claims.", "Each reference, including all patent, patent applications, and publications, cited in the present application is incorporated herein by reference in its entirety." ] ]
Patent_15874140
[ [ "DERMAL INJECTABLE STERILE COMPOSITION", "The present invention relates to a crosslinked hyaluronic acid gel which derives from the crosslinking of hyaluronic acid or of a salt thereof in the presence of at least an effective amount of at least one endogenous polyamine as a crosslinking agent, said crosslinking being carried out under conditions favourable to the coupling of said hyaluronic acid and of said endogenous polyamine(s)." ], [ "1.A process for preparing a crosslinked gel of hyaluronic acid or a salt thereof, comprising at least the steps: a) providing an aqueous gel of hyaluronic acid or of a salt thereof, in the noncrosslinked state, b) bringing the gel obtained in step a) into contact with an effective amount of at least one endogenous polyamine, wherein said at least one endogenous polyamine is used in a content between 0.1% and 3% by number of moles of the at least one endogenous polyamine relative to the number of moles of hyaluronic acid, c) crosslinking said mixture formed in step b), said crosslinking being carried out under conditions favourable to the covalent coupling of said hyaluronic acid and of said at least one endogenous polyamine(s), and d) recovering said crosslinked hydrogel, wherein said crosslinked hydrogel has a degree of modification of less than or equal to 1%, the degree of modification being the ratio between the number of moles of endogenous polyamine attached to the hyaluronic acid and the number of moles of hyaluronic acid forming said crosslinked gel.", "2.The process according to claim 1, wherein said process also comprises a step e) of stopping the crosslinking, consisting in exposing the crosslinked gel to conditions favourable to stopping the crosslinking thereof, it being possible for this step to be carried out before, jointly with or after the recovering step d).", "3.The process according to claim 1, wherein the at least one endogenous polyamine is selected from the group consisting of spermidine, spermine, and a mixture thereof.", "4.The process according to claim 1, wherein the hyaluronic acid or a salt thereof is used in a content of between 0.5% and 12% by weight relative to the total weight of the mixture obtained at the end of step b).", "5.The process according to claim 1, wherein the crosslinking is carried out in the presence of a supplementary crosslinking agent.", "6.The process according to claim 1, wherein the coupling is carried out in the presence of at least one activator and, optionally combined with at least one auxiliary coupling agent.", "7.The process according to claim 1, which comprises uses (i) sodium hyaluronate, (ii) spermine, as crosslinking agent, and (iii) 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) in combination with N-hydroxybenzotriazole (HOBt), as, respectively, activator and auxiliary coupling agent." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a Divisional of U.S. application Ser.", "No.", "14/437,917 filed on Oct. 24, 2013, which is the National Phase filing under 35 U.S.C.", "§ 371 of PCT/IB2013/059607 filed on Oct. 24, 2013; and this application claims priority to Application No.", "1260146 filed in France on Oct. 24, 2012.The entire contents of each application are hereby incorporated by reference.", "The present invention relates to the field of sterile injectable compositions based on hyaluronic acid or on a salt thereof and intended for the treatment of skin defects and imperfections.", "Hyaluronic acid, which is naturally present in the skin, is known for its viscoelastic properties and also its very high propensity to absorb water.", "Its properties contribute to a large extent to the elasticity of the skin.", "Given its properties and its qualities of biocompatibility, tolerance and lack of toxicity, advantage has thus been taken of this compound for more than 10 years now in many applications in the medical and cosmetics fields, and in particular aesthetic procedures.", "Thus, hyaluronic acid is used for filling wrinkles and for reducing, or even eliminating, local weakening of the structure of the dermis represented by a wrinkle or skin depression, generally via a direct injection into the dermis, in the area under consideration.", "Unmodified hyaluronic acid is perfectly biocompatible and identical to endogenous hyaluronic acid.", "However, hyaluronic acid is used essentially in the form of a gel based on crosslinked hyaluronic acid, and therefore in a modified form given the increased resistance of this particular form to degradation, to heat and therefore to sterilization.", "These crosslinked hyaluronic acid gels can be obtained by various preparation processes.", "Generally, these processes require two main steps, the first consisting in hydrating the hyaluronic acid in order to convert it into an aqueous gel and the second aimed at crosslinking said aqueous gel in the presence of an agent capable of inducing the crosslinking thereof (also referred to as “crosslinking agent”).", "This agent is usually chosen from epoxide, aldehyde, polyaziridyl or divinylsulphone (DVS), or butanediol diglycidyl ether (BDDE), and is therefore synthetic in nature.", "By way of illustration of these processes, mention may in particular be made of those described in documents US 2006/0105022, WO 2006/056204 and US 2007/0036745.The crosslinked gels currently on the market and obtained with conventional crosslinking agents generally have degrees of modification of greater than 4%, or even degrees of modification up to 10%.", "For the purposes of the present invention, the term “degree of modification” is intended to denote the ratio between the number of moles of crosslinking agent attached to the hyaluronic acid and the number of moles of hyaluronic acid forming said crosslinked gel.", "This quantity can in particular be measured by 1D 1H NMR analysis of the crosslinked gel.", "The expression “number of moles of hyaluronic acid” is intended to mean the number of moles of repeating disaccharide units of the hyaluronic acid, the disaccharide unit being composed of D-glucuronic acid and D-N-acetylglucosamine linked to one another via alternating beta-1,4 and beta-1,3 glycosidic bonds.", "However, with a view to getting as close as possible to endogenous hyaluronic acid, it would be desirable to have crosslinked hyaluronic acid gels with a lower degree of modification.", "Admittedly, crosslinked gels with lower degrees of modification (i.e.", "between 1% and 2%) have already been proposed.", "Unfortunately, they prove to be poorly cohesive and have a low resistance to crushing.", "These deficiencies manifest themselves in particular in oscillatory rheology through a restricted viscoelasticity range (the viscoelasticity range is represented by the stress range in which G′ remains constant, during a measurement with stress sweep.", "The extent of this viscoelasticity range can in particular be assessed by measuring the cross-over stress, i.e.", "the stress at which the value of G′ decreases and equals the value of G″).", "This behaviour is therefore to be improved for applications in filling wrinkles.", "More specifically, there remains a need for gels of crosslinked hyaluronic acid with the lowest possible degrees of modification, which at the same time remain satisfactory in terms of the mechanical properties exhibited.", "Against all expectations, the inventors have noted that such a gel can be obtained when the crosslinking step is carried out in the presence of a specific type of compound.", "Thus, according to a first aspect of the invention, the subject thereof is a crosslinked hyaluronic acid gel which derives from the crosslinking of hyaluronic acid or of a salt thereof in the presence of at least an effective amount of at least one endogenous polyamine as crosslinking agent, said crosslinking being carried out under conditions favourable to the covalent coupling of said hyaluronic acid and of said endogenous polyamine(s).", "Admittedly, polyamines, which are nevertheless distinct from those considered according to the invention, have already been proposed for the formation of crosslinked hyaluronic acid hydrogels.", "Thus, the publications by Xiang Mei Yuan et al.", "(Journal of biomaterials Applications 0(0) 1-9; 27 Feb. 2012) and by Junseok Yeom et al.", "(Bioconjugate Chem., 1991(2) 232-241), and also application WO 2012/008722, provide hyaluronic acid (HA) hydrogels crosslinked in the presence of hexamethylenediamine (HMDA).", "However, the polyamine considered, namely hexamethylenediamine (HMDA), is a synthetic diamine and therefore not an endogenous diamine what is more, the amounts of crosslinking agent (HMDA) used in this prior art range between 25% and 72% and result in very high degrees of modification of between 5% and 35%.", "The term “amount of crosslinking agent” is intended to denote the ratio between the number of moles of polyamine(s) and the number of moles of hyaluronic acid, used to synthesize the gel.", "Finally, as emerges from the examples hereinafter, the HA-HMDA gels prove to be significantly less effective in terms of mechanical properties than those obtained according to the invention.", "As regards the endogenous polyamines considered according to the invention, application WO 2008/015249 proposes, for its part, to use them together with hyaluronic acid particles for topical use as an anti-ageing active agent and as an antioxidant.", "For obvious reasons, such a mixture is very different from the gels considered according to the invention.", "The publication by Di Meo et al.", "(Biomacromolecules, 2006, 7:1253-60) describes the formation of hydrogels via the Ugi reaction or else condensation of hyaluronic acid and spermidine.", "This therefore involves a mechanism which is different from that considered in the present invention.", "What is more, the hydrogels thus obtained and not dedicated to a use in accordance with the invention result from a process using high amounts of crosslinking agent (between 5% and 25%).", "The inventors have therefore noted that an endogenous polyamine constitutes a crosslinking agent of choice for obtaining a crosslinked hyaluronic acid gel in accordance with the abovementioned expectations, namely which has a reduced degree of modification compared with those observed with crosslinking agents usually considered, and mechanical properties and a resistance to sterilization that are particularly satisfactory.", "Indeed, the crosslinked gels according to the invention have a significantly reduced degree of modification, namely less than or equal to 1%, while at the same time remaining satisfactory in terms of mechanical properties.", "A crosslinked gel according to the invention also proves to be advantageous in that it consists of compounds that are naturally present in most living organisms and human beings in particular.", "From the viewpoint of this pseudonatural nature, it meets an increasing demand by consumers in this respect.", "Finally, it is likely that the properties intrinsic to the endogenous polyamines considered according to the invention are preserved within the crosslinked hyaluronic acid gel obtained according to the invention.", "As it happens, insofar as these properties have an antioxidant effect, or even anti-ageing effect, they are particularly pleasant in the context of the present invention.", "According to another aspect of the present invention, the subject thereof is a sterile injectable dermatological composition comprising, in a physiologically acceptable medium, at least one crosslinked hyaluronic acid gel according to the invention.", "For the purposes of the present invention, the term “skin” encompasses the skin of the face, of the neck, of the neckline, of the hands, of the scalp, of the abdomen and/or of the legs, but also the lips.", "The term “sterile” is intended to qualify an environment capable of guaranteeing the compounds considered in the composition according to the invention, and/or said composition which contains them, the innocuity required for administration in or through the skin, in particular intraepidermal and/or intradermal and/or subcutaneous administration.", "In particular, it is essential for the composition containing said compounds and which has to be administered according to an injection technique, for example according to the mesotheraphy technique, to be devoid of any contaminating body capable of initiating an adverse side reaction in the host organism.", "For the purposes of the present invention, the term “injectable” is intended to denote a composition of which the mechanical properties are appropriate for the use considered, namely its administration in or through the skin for, in particular, filling wrinkles.", "Thus, a composition according to the invention is injectable via a fine hypodermic needle (in particular with a diameter of less than 18 G, or even less than 27 G), and advantageously has an elastic modulus (G′) of between 20 and 1000 Pa, preferably between 40 Pa and 400 Pa, with a phase angle (δ) of less than 45°.", "This elastic modulus (G′) and the phase angle (δ) are measured via the protocol defined hereinafter.", "According to yet another aspect of the present invention, the subject thereof is a dermatological or cosmetic composition comprising at least one crosslinked hyaluronic acid gel according to the invention.", "This embodiment, which is not limited in terms of route of administration, consequently permits the administration of said composition topically.", "According to another aspect of the present invention, the subject thereof is a kit comprising: a packaging containing at least one dose of a crosslinked hyaluronic acid gel according to the invention or of a composition according to the invention; and a device for injecting in or through the skin or a device for microperforation of the skin, dedicated to the administration of said dose.", "According to yet another aspect of the invention, the subject thereof is the use of a crosslinked gel or of a composition according to the invention, for filling skin volume defects and in particular filling wrinkles.", "According to yet another aspect of the invention, the subject thereof is the use of a crosslinked gel or of a composition according to the invention for preventing and/or treating the cutaneous signs of chronological ageing and/or the cutaneous signs which are induced by external factors such as stress, atmospheric pollution, tobacco or prolonged exposure to ultraviolet (UV) radiation.", "According to yet another aspect of the invention, the subject thereof is the use of a crosslinked gel or of a composition according to the invention for preventing and/or treating a modification of the surface appearance of the skin.", "According to yet another aspect of the invention, the subject thereof is the use of a crosslinked gel or of a composition according to the invention for preventing and/or treating a modification of the viscoelastic or biomechanical properties of the skin.", "For the purpose of the present invention, the term “prevention” is intended to mean reducing the risk of occurrence of a phenomenon.", "According to another aspect of the invention, the subject thereof is a cosmetic skin treatment process, comprising at least one step of administering, in or through the skin, a crosslinked gel or a composition according to the invention.", "According to yet another aspect of the present invention, the latter relates to a process for preparing a crosslinked gel of hyaluronic acid or a salt thereof, comprising at least the steps consisting in: a) providing an aqueous gel of hyaluronic acid or of a salt thereof, in the noncrosslinked state, b) bringing the gel obtained in step a) into contact with an effective amount of at least one endogenous polyamine, c) crosslinking said mixture formed in step b), said crosslinking being carried out under conditions favourable to the covalent coupling of said hyaluronic acid and of said endogenous polyamine(s), and d) recovering said crosslinked hydrogel.", "According to one particular embodiment, the process also comprises a step e) of stopping the crosslinking, consisting in exposing the crosslinked gel to conditions favourable to stopping the crosslinking thereof, it being possible for this step to be carried out before, jointly with or after the recovering step d).", "Crosslinked Hyaluronic Acid Gel As previously indicated, a crosslinked hyaluronic acid gel according to the invention derives from the crosslinking of at least hyaluronic acid or a salt thereof with, as crosslinking agent, at least one endogenous polyamine, said crosslinking being carried out under conditions favourable to the coupling of said hyaluronic acid and of said endogenous polyamine(s).", "Hyaluronic acids are linear polysaccharides with alternating D-glucuronic acid and N-acetyl-D-glucosamine units.", "The are naturally present in several tissues and are degraded by hyaluronidases, which are present throughout the body, or via oxidation mechanisms.", "For the purpose of the present invention, the term “endogenous polyamine” is intended to denote a polyamine that is naturally present in living organisms and more particularly the human body.", "A polyamine according to the invention consequently differs from hexamethylenediamine (HMDA) which is a polyamine of synthetic origin.", "By way of representation of endogenous polyamines, mention may quite particularly be made, in animal eukaryotes, of putrescine (or 1,4-diaminobutane), spermidine (or 1,8-diamino-5-azaoctane) and spermine (1,12-diamino-5,9-diazadodecane).", "Spermine is a tetraamine and is synthesized from spermidine.", "Advantageously, the endogenous polyamine used for obtaining a crosslinked gel according to the invention can be chosen from spermidine, spermine, and a mixture thereof, and better still spermine.", "This selection is all the more advantageous since spermine and spermidine are involved in numerous fundamental cell mechanisms, such as DNA synthesis and gene expression.", "Used topically, their beneficial effects on improving the condition of the skin and reducing the signs of ageing have already been described (see in particular application WO 2006/048671).", "These compounds are also considered to be antioxidants and anti-ageing active agents of choice.", "The coupling reaction considered in the present invention to achieve crosslinking reaction between the hyaluronic acid and the endogenous polyamine(s) is carried out by reaction between an amine function and carboxylic acid, thus giving rise to the formation of an amide function.", "In other words, the crosslinking reaction considered in the present invention leads to the formation of molecules of crosslinked hyaluronic acid covalently coupled with the endogenous polyamine(s).", "There is no electrostatic interactions.", "Against all expectations, the resulting crosslinked gels, in the light of the degrees of modification considered very reduced, show mechanical properties which are very satisfactory, or even unattainable by means of the conventional processes as mentioned previously.", "Thus, according to one particular embodiment, a crosslinked gel according to the invention advantageously has a degree of modification of less than or equal to 1%, preferably between 0.1% and 1%, and better still between 0.4% and 0.8%.", "As previously indicated, the “degree of modification” corresponds to the ratio between the number of moles of endogenous polyamine attached to the hyaluronic acid and the number of moles of hyaluronic acid forming said crosslinked gel.", "This quantity can in particular be measured by 1D 1H NMR analysis of the crosslinked gel.", "It is recalled that the expression “number of moles of hyaluronic acid” is intended to mean the number of moles of repeating disaccharide units of the hyaluronic acid, the disaccharide unit being composed of D-glucuronic acid and D-N-acetylglucosamine linked to one another via alternating beta-1,4 and beta-1,3 glycosidic bonds.", "According to one particular embodiment, a crosslinked gel according to the invention is such that it can comprise from 0.5% to 40% by weight of hyaluronic acid not subjected to the crosslinking reaction, relative to the total amount of hyaluronic acid.", "According to another particular embodiment, a crosslinked gel according to the invention can have a hyaluronic acid concentration of between 5 and 30 mg/g.", "According to yet another particular embodiment, a crosslinked gel according to the invention can have an elastic modulus (G′) of between 20 and 1000 Pa, preferably between 40 Pa and 400 Pa.", "According to one particular embodiment, a crosslinked gel according to the invention can be in the form of a predominantly elastic, viscoelastic hydrogel with a phase angle (δ) of less than 45°.", "According to one preferred embodiment, a crosslinked gel according to the invention can have an elastic modulus (G′) of between 20 and 1000 Pa, preferably between 40 Pa and 400 Pa, combined with a phase angle (δ) of less than 45°.", "In particular, a crosslinked hyaluronic acid gel in accordance with the invention can be injectable via a hypodermic needle with a diameter between 34 G and 18 G. According to yet another particular embodiment, a crosslinked gel according to the invention is highly cohesive.", "This characteristic manifests itself in particular through a high stress-sweep cross-over stress, of greater than 100 Pa.", "The elastic modulus (G′, in Pa) and the phase angle (δ, in °) can be measured according to the following protocol: The measurements are carried out at 25° C. at a frequency of 1 Hz, with a stress sweep using a Thermo Haake RS3000 rheometer with a cone-plate geometry of 1°/35 mm diameter.", "G′ and δ are recorded at an applied deformation stress of 5 Pa, i.e.", "in the viscoelasticity range where G′ and δ remain stable.", "The value of the cross-over stress (when G′ decreases to equal the viscous modulus G″) is then also recorded.", "For a cohesive gel according to the invention, this cross-over stress is therefore greater than 100 Pa.", "Finally, according to one particular embodiment, a crosslinked gel according to the invention can have a high resistance to sterilization (the loss of G′ caused by the sterilization is less than 50%).", "The sterilization can be carried out in an autoclave (wet heat) at T°≥121° C., so as to obtain an F0>15 (sterilizing value).", "As previously indicated, the crosslinking reaction for obtaining a crosslinked gel according to the invention is carried out under conditions favourable to the covalent coupling of said hyaluronic acid and of said endogenous polyamine(s).", "For the purpose of the present invention, the term “favourable conditions” is intended to mean an element which initiates said coupling.", "The choice of this initiating element is clearly among the skills of those skilled in the art.", "Generally, this coupling is carried out via at least one “activator” compound, where appropriate combined with at least one “auxiliary coupling agent”.", "For example, such an activator can have the function of making the carbon of the carboxyl group of the hyaluronic acid more electrophilic and therefore of thus stimulating its reactivity with regard to one of the amine groups of the endogenous polyamine.", "The activator can advantageously be a condensation agent, for example a pyridinium salt, for instance 2-chloro-1-methylpyridinium as described in the document Magnani, A. et al.", "(Polymers for Advanced Technologies 1 1, 488-495 (2000)), a carbodiimide as described in the document Bulpitt, P. & Aeschlimann (J. of Biomed.", "Materials Res.", "47, 152-169 (1999)), or a triazine derivative as described in the document Bergman et al.", "(Biomacromolecules 8, 2190-2195 (2007)).", "Preferably, such an activator can be chosen from water-soluble carbodiimides, such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), 1-ethyl-3-(3-trimethylaminopropyl)carbodiimide (ETC), 1-cyclohexyl-3-(2-morphilinoethyl)carbodiimide (CMC), and also salts thereof, and mixtures thereof, and is preferably represented by EDC.", "Preferably, an auxiliary coupling agent, when it is present, can be chosen from N-hydroxysuccinimide (NHS), N-hydroxybenzotriazole (HOBt), 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazole (HOOBt), 1-hydroxy-7-azabenzotriazole (HAt) and N-hydroxysulphosuccinimide (sulpho NHS), and mixtures thereof, and is preferably represented by HOBt.", "Even more preferably, such an activator can be chosen from EDC, where appropriate in combination with HOBt as auxiliary coupling agent.", "The EDC makes it possible to activate the carboxylic acid by forming an intermediate with the carboxylate.", "The addition of HOBt to the reaction medium makes it possible in particular to avoid any epimerization and to promote the reaction.", "Process for Preparing a Crosslinked Gel As indicated above, the present invention also relates to a process for preparing a crosslinked gel of hyaluronic acid or a salt thereof, comprising at least the steps consisting in: a) providing an aqueous gel of hyaluronic acid or of a salt thereof, in the noncrosslinked state, b) bringing the gel obtained in step a) into contact with an effective amount of at least one endogenous polyamine, c) crosslinking said mixture formed in step b), said crosslinking being carried out under conditions favourable to the covalent coupling of said hyaluronic acid and of said endogenous polyamine(s), and d) recovering said crosslinked hydrogel.", "According to one particular embodiment, the process also comprises a step e) of stopping the crosslinking, consisting in exposing the crosslinked gel to conditions favourable to stopping the crosslinking thereof, it being possible for this step to be carried out before, jointly with or after the recovering step d).", "According to one particular embodiment, the crosslinking step c) can be carried out in the presence of at least one activator, optionally combined with at least one auxiliary coupling agent, i.e.", "compounds which stimulate the reactivity of at least one of the two compounds to be coupled, preferably chosen from those previously mentioned.", "This step of adding the activator, and optionally the auxiliary coupling agent, can therefore advantageously be carried out jointly with the crosslinking step c).", "According to one particular embodiment, the hyaluronic acid used for obtaining a gel according to the invention may be in salt form.", "Preferably, a hyaluronic acid salt may be chosen from the sodium salt, the potassium salt, the zinc salt, the silver salt, and a mixture thereof, preferably the sodium salt.", "Advantageously, the hyaluronic acid used for obtaining a gel according to the invention may have an average molecular weight ranging from 50 000 to 10 000 000 daltons, preferably from 500 000 to 4 000 000 daltons.", "The adjustment of the amount of hyaluronic acid for carrying out the crosslinking reaction is clearly among the skills of those skilled in the art.", "Advantageously, the hyaluronic acid or a salt thereof can be used in a process for preparing a crosslinked gel according to the invention in a content of between 0.5% and 12% by weight, preferably between 1% and 4% by weight, relative to the total weight of the mixture obtained at the end of step b), i.e.", "before carrying out the crosslinking step c).", "The adjustment of the amount of endogenous polyamine(s) for carrying out the crosslinking reaction is clearly among the skills of those skilled in the art.", "The amount of crosslinking agent corresponds to the ratio between the number of moles of polyamine(s) and the number of moles of hyaluronic acid, used for synthesizing the gel.", "Advantageously, one or more endogenous polyamine(s) may be used in a process for preparing a crosslinked hyaluronic acid gel according to the invention in a content of between 0.1% and 3%, preferably between 0.5% and 1.5% by number of moles of polyamine(s) relative to the number of moles of hyaluronic acid that are present in the reaction medium, i.e.", "the mixture of step b).", "Advantageously, the activator(s), where appropriate combined with one or more auxiliary coupling agent(s), may be used in a process for preparing a crosslinked hyaluronic acid gel according to the invention in a content such that the number of moles of activator(s) and, where appropriate, of auxiliary coupling agent(s), relative to the number of moles of hyaluronic acid of the reaction medium (n activator/n HA) is between 0.1 and 2, preferably between 0.5 and 1.5.The crosslinked hyaluronic acid gel is obtained by taking into consideration the presence of at least one endogenous polyamine.", "Consequently, the crosslinking can be carried out using only this type of crosslinking agent.", "However, this crosslinking can also be carried out by taking into consideration the simultaneous presence of at least one supplementary, in particular conventional, crosslinking agent.", "Advantageously, this supplementary crosslinking agent can then be taken into consideration in a significantly reduced amount compared with those conventionally retained when it is used as sole crosslinking agent.", "This supplementary crosslinking agent can be chosen from epoxide, aldehyde, polyaziridyl, polyamines distinct from the endogenous polyamines, polyphosphates, divinylsulphone (DVS), and mixtures thereof, preferably from epoxide crosslinking agents, which are preferably bifunctional or multifunctional.", "Preferably, the supplementary crosslinking agent can be chosen from epoxide, more particularly from 1,4-butanediol diglycidyl ether (BDDE), diepoxyoctane or 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, 1,4-bis(2,3-epoxypropoxy)butane, 1,4-bisglycidyloxybutane, 1,2-bis(2,3-epoxypropoxy)ethylene, 1-(2,3-epoxypropyl)-2,3-epoxycyclohexane, and mixtures thereof, and better still 1,4-butanediol diglycidyl ether (BDDE).", "Moreover, the presence of an inorganic salt of an alkali metal halide can also be considered during the crosslinking reaction.", "Indeed, unexpectedly, the inventors have noted that the presence of an inorganic salt of an alkali halide while carrying out the crosslinking reaction makes it possible to further improve the rheological properties of the crosslinked gel for the same degree of crosslinking.", "For the purpose of the present invention, the term “salt of an alkali halide” is intended to denote a compound made up of an alkali cation and of an anion necessarily representing a halogen atom.", "Advantageously, the halogen atom can be chosen from fluorine, chlorine, bromine and iodine, and is preferably represented by chlorine.", "Preferably, an inorganic salt of an alkali halide according to the invention can be chosen from the sodium salts, potassium salts and caesium salts, and better still is represented by a sodium salt.", "Even more preferably, an inorganic salt of an alkali halide according to the invention may be NaCl.", "NaCl in fact has the advantage of being physiologically acceptable and it is one of the constituents of one of the raw materials which are part of the composition of the crosslinked hyaluronic acid gels.", "Advantageously, the inorganic salt(s) of an alkali halide may be used in a process according to the invention in a content of between 0.5% and 20% by weight, preferably between 1% and 10% by weight, relative to the total weight of the mixture obtained at the end of step b).", "In the light of the aforementioned, a process for preparing a crosslinked hyaluronic acid gel according to the invention requires, firstly, providing an aqueous gel comprising at least hyaluronic acid in a noncrosslinked form, combined with at least one endogenous polyamine, as a crosslinking agent.", "For the purpose of the present invention, the term “noncrosslinked” is intended to denote an aqueous gel of hyaluronic acid which is not crosslinked or not transformed, i.e.", "a solution of hyaluronic acid of which the chains of the polymer are not connected to one another by strong or covalent bonds.", "More specifically, the aqueous gel considered in step a) can be obtained beforehand by bringing together, in an appropriate receptacle: (i) an aqueous medium; (ii) at least hyaluronic acid, or a salt thereof, in a noncrosslinked form; and (iii) where appropriate, at least one endogenous polyamine; and homogenizing the resulting mixture, the order of addition of said compounds (i), (ii) and (iii) to the receptacle being unimportant.", "In other words, in the event that the aqueous gel of step a) takes into consideration the presence of at least one endogenous polyamine, steps a) and b) of the process according to the invention are then carried out concomitantly.", "According to a first embodiment variant, this aqueous gel can be formed by introduction of the aqueous medium and of the hyaluronic acid into the receptacle, with simultaneous and/or consecutive homogenization of the mixture thus formed, and then, where appropriate, addition of the crosslinking agent with simultaneous and/or consecutive homogenization.", "According to a second embodiment variant, this aqueous gel can be obtained by introduction of the aqueous medium, of the hyaluronic acid and of the crosslinking agent into the receptacle, with simultaneous and/or consecutive homogenization of the mixture thus formed.", "This second embodiment variant is advantageous in that a single homogenization step is carried out.", "Advantageously, this step of forming the aqueous gel can be carried out at a temperature below 35° C., preferably at a temperature ranging from 15 to 25° C., and better still at an ambient temperature.", "The aqueous gel considered in step a) is advantageously homogeneous.", "This quality is guaranteed by an operation in which the aqueous gel is homogenized, said operation possibly constituting a step preliminary to step a).", "The purpose of this operation, optionally carried out in the presence of the crosslinking agent, is more particularly to hydrate and completely homogenize the hyaluronic acid in the aqueous medium and, where appropriate, the crosslinking agent, and thus to contribute to the optimization of the qualities of the expected crosslinked gel.", "Indeed, for obvious reasons, the homogeneity of the crosslinked gel is closely linked to the homogeneous nature of the gel before crosslinking.", "The homogenization is considered to be satisfactory when the solution obtained has a homogeneous colouration, without agglomerates, and a uniform viscosity.", "It can advantageously be carried out under mild operating conditions in order to prevent degradation of the hyaluronic acid chains.", "This step is all the more important when the hyaluronic acid has a high molecular weight.", "The hydration of such a compound then in fact has a tendency to generate the formation of a solution of high viscosity in which the appearance of agglomerates is commonly observed.", "As emerges from the aforementioned, the mixture formed in step b), or even, where appropriate, the aqueous gel of step a) when it takes into consideration the presence of the crosslinking agent, is subsequently subjected to a crosslinking reaction, illustrated by step c) of the process for preparing a crosslinked hyaluronic acid gel according to the invention.", "As previously indicated, this crosslinking is carried out under conditions favourable to the coupling of said hyaluronic acid and of said endogenous polyamine(s).", "The favourable conditions to be retained in order to induce this coupling, and therefore the crosslinking reaction, can depend on the molecular weight of the hyaluronic acid, on the aqueous medium and on the nature of the crosslinking agent, in this case completely or partially formed by an endogenous polyamine.", "These favourable conditions can in particular be reflected by the presence of at least one activator, where appropriate combined with at least one auxiliary coupling agent, as indicated above.", "As previously indicated, the step of adding the activator and, where appropriate, the auxiliary coupling agent, can preferably be carried out jointly with the crosslinking step c).", "However, according to one particular embodiment, the activator and, where appropriate, the auxiliary coupling agent is (are) added before the crosslinking step c), and more particularly before the step of adding at least one endogenous polyamine.", "According to another embodiment, this step of adding the activator and, where appropriate, the auxiliary coupling agent is carried out jointly with step b), in which case step b) is then carried out jointly with the crosslinking step c).", "Moreover, the degree of crosslinking also depends on the duration of the crosslinking step applied to the mixture obtained at the end of step b).", "The longer the time, the higher the degree of crosslinking, with, however, an optimum that is not to be exceeded, otherwise there is a risk of degrading the hyaluronic acid.", "Thus, when the crosslinking of the hyaluronic acid is carried out in the presence of EDC and of HOBt, the crosslinking step c) can be carried out over a period ranging from 30 minutes to 72 hours, preferentially from 3 to 24 hours.", "As previously described, the stopping of the crosslinking (step e) can occur before, jointly with or after the step d) of recovering the gel.", "Such a step e) may require exposing the crosslinked gel or the gel undergoing crosslinking, or even the receptacle containing it, to conditions favourable to stopping said crosslinking, or else to conditions capable of stopping the formation of bonds between the various polysaccharide chains.", "This step can be initiated naturally if all the reagents are consumed during step c), or promoted by a purification step which brings the gel back to physiological pH and eliminates the unreacted residual reagents.", "According to one preferred embodiment variant, step e) is carried out before step d).", "According to one particularly preferred embodiment, the process according to the invention uses (i) sodium hyaluronate, (ii) spermine, as crosslinking agent, and (iii) EDC, as activator, in combination with HOBt, as auxiliary coupling agent.", "For obvious reasons, the crosslinked gel obtained at the end of the process of the invention is not generally directly injectable because the corresponding aqueous formulation may not be compatible with physiological conditions, nor have a suitable pH.", "Thus, one or more additional steps, known to those skilled in the art, may be carried out.", "More particularly, a step of purifying the gel according to the invention makes it possible to bring the latter back to physiological pH and to eliminate the unreacted residual reagents.", "This purification step may in particular be represented by a dialysis step.", "What is more, subsequent steps of homogenization, of incorporation of noncrosslinked hyaluronic acid and, optionally, of fractionation may also be carried out in order to further improve the qualities of the implant, according to the knowhow of those skilled in the art.", "The gel must be formulated physiologically through the presence of salts in amounts equivalent to those of the injected medium.", "Finally, the resulting hydrogel may be packed into syringes under controlled atmosphere conditions, it being possible for said syringes to then undergo a sterilization step, preferably heat sterilization.", "Composition According to another aspect, as indicated above, of the present invention, the latter also relates to a sterile injectable dermatological composition comprising, in a physiologically acceptable medium, at least one crosslinked hyaluronic acid gel as defined above.", "By virtue of its injectable nature, a composition according to the invention therefore necessarily comprises a physiologically acceptable medium.", "The term “physiologically acceptable medium” is intended to mean a medium which is devoid of toxicity and is compatible with the injection and/or the application of the composition in or through keratin materials.", "The composition may comprise a physiologically acceptable solvent or a mixture of physiologically acceptable solvents.", "The composition may comprise a physiologically acceptable aqueous medium.", "By way of aqueous medium that is suitable for the invention, mention may, for example, be made of water.", "By way of isotonic agents that are suitable for the preparation of a composition that is suitable for the invention, mention may be made of sugars and sodium chloride.", "According to yet another aspect, as indicated above, of the present invention, the latter relates to a dermatological or cosmetic composition comprising at least one crosslinked hyaluronic acid gel according to the invention.", "This embodiment, which is not limited in terms of route of administration, consequently permits the administration of said composition topically.", "Additional Active Agents A composition according to the invention may also comprise at least one additional active agent that is compatible with use in the field of sterile injectable compositions.", "Among the additional active agents usable in the present invention, mention may be made of antioxidants, amino acids, vitamins, minerals, nucleic acids, coenzymes, adrenaline-containing derivatives, and mixtures thereof.", "By way of antioxidants, mention may in particular be made of glutathione, ellagic acid, spermine, resveratrol, retinol, L-carnitine, polyols, polyphenols, flavonols, theaflavins, catechins, caffeine, ubiquinol, ubiquinone, and a mixture thereof.", "By way of amino acids, mention may in particular be made of arginine, isoleucine, leucine, lysine, glycine, valine, threonine, proline, methionine, histidine, phenylalanine, tryptophan, and a mixture thereof.", "By way of vitamins or derivatives thereof, mention may in particular be made of vitamins E, A, C and B, more particularly vitamins B6, B8, B4, B5, B9, B7 and B12, and better still pyridoxine.", "By way of minerals, mention may in particular be made of the zinc salts, magnesium salts, calcium salts, potassium salts, manganese salts, sodium salts, and a mixture thereof.", "By way of nucleic acids, mention may in particular be made of derivatives of adenosine, of cytidine, of guanosine, of thymidine, of cytodine, and a mixture thereof.", "By way of coenzymes, mention may in particular be made of coenzyme Q10, CoA, NAD, NADP, and a mixture thereof.", "By way of adrenaline-containing derivatives, mention may particularly be made of adrenaline and noradrenaline.", "Moreover, a composition according to the invention may also comprise any excipient normally used in the technical field considered, such as, for example, sodium dihydrogen phosphate monohydrate and/or dihydrate, and sodium chloride, in physiologically suitable contents.", "The amounts of additional active agents and/or excipients depend of course on the nature of the compound considered, on the desired effect, and on the destination of the composition according to the invention.", "These parameters are among the general skills of those skilled in the art.", "Advantageously, a composition according to the invention may comprise from 2 ppm to 10 000 ppm, preferably from 5 to 1000 ppm, and better still from 50 to 500 ppm of additional active agents and/or excipients relative to the total weight of said composition.", "Moreover, it is known that the injection of a composition dedicated to filling wrinkles often causes a painful sensation for the patient.", "Thus, according to one particular embodiment, a composition according to the invention may also comprise at least one anaesthetic agent.", "An anaesthetic agent has precisely the advantage of reducing, or even eliminating, the painful sensation felt by the patient at the time of and/or following the administration of a composition in accordance with the invention.", "What is more, the inventors have noted that the presence of such a compound does not raise any risk of incompatibility with the other compounds used in a composition according to the invention, and in particular with the hyaluronic acid.", "An anaesthetic usable in the present invention may be chosen from ambucaine, amolanone, amylocaine, articaine, benoxinate, benzocaine, betoxycaine, biphenamine, bupivacaine, butacaine, butamben, butanilicaine, butethamine, butoxycaine, carticaine, chloroprocaine, cocaethylene, cocaine, cyclomethycaine, dibucaine, dimethisoquin, dimethocaine, diperodone, dycyclonine, ecgonidine, ecgonine, ethyl chloride, etidocaine, beta-eucaine, euprocine, fenalcomine, formocaine, hexylcaine, hydroxytetracaine, isobutyl p-aminobenzoate, leucinocaine mesylate, levoxadrol, lidocaine, mepivacaine, meprylcaine, metabutoxycaine, methyl chloride, myrtecaine, naepaine, octacaine, orthocaine, oxethazaine, parethoxycaine, phenacaine, phenol, piperocaine, piridocaine, polidocanol, pramoxine, prilocaine, procaine, propanocaine, proparacaine, propipocaine, propoxycaine, pseudococaine, pyrrocaine, ropivacaine, salicyl alcohol, tetracaine, tolycaine, trimecaine, zolamine, or a salt thereof.", "More particularly, an anaesthetic usable in the present invention may be chosen from articaine, benzocaine, bupivacaine, chloroprocaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, and tetracaine.", "Preferably, the anaesthetic may be lidocaine, and better still lidocaine hydrochloride.", "A composition according to the invention may advantageously comprise from 0.01% to 1% by weight, preferably from 0.1% to 0.5% by weight of anaesthetic(s), relative to the total weight of said composition.", "According to one particular embodiment, a gel or a composition according to the invention, in addition to the hyaluronic acid in a crosslinked form, may also comprise hyaluronic acid in a noncrosslinked form.", "Such a combination of hyaluronic acid in free and crosslinked form immediately results in moisturization and maintenance of the volume of the skin.", "Furthermore, it induces a boosting of dermal fibroblasts, mainly due to the presence of free hyaluronic acid, and this boosting of fibroblasts is prolonged over time as the crosslinked hyaluronic acid is degraded in vivo.", "From a functional point of view, the presence of noncrosslinked hyaluronic acid makes it possible to significantly improve the forces of extrusion of the gel through a needle, thus facilitating the force to be applied by the practitioner for injecting the product.", "Administration of the Sterile, Injectable Crosslinked Hyaluronic Acid Gel or Dermatological Composition A crosslinked hyaluronic acid gel or a composition according to the invention can be injected using any one of the modes known to those skilled in the art.", "In particular, a gel or a composition according to the invention may be administered by means of an injection device suitable for an intraepidermal and/or intradermal and/or subcutaneous injection.", "The injection device may be chosen from a syringe, a set of microsyringes, a hydraulic, laser device, an injection gun, a needleless injection device, or a microneedle roller.", "Preferably, the injection device may be chosen from a syringe or a set of microsyringes.", "Preferably, such a means may be a hypodermic needle or a cannula.", "A needle or cannula according to the invention may have a diameter ranging from 18 to 34 G, preferably between 25 and 32 G, and a length ranging from 4 to 70 mm, and preferably from 4 to 25 mm.", "The needle or cannula is advantageously disposable.", "Advantageously, the needle or cannula is combined with a syringe or any other device for delivering said injectable composition through the needle or the cannula.", "According to one embodiment variant, a catheter may be inserted between the needle/the cannula and the syringe.", "In a known manner, the syringe may be operated manually by the practitioner or else by means of a syringe support, such as guns.", "Kit According to another aspect of the present invention, the latter relates to a kit comprising: a packaging containing at least one dose of a crosslinked hyaluronic acid gel or of a composition according to the invention; and a device for injecting in or through the skin or a device for microperforation of the skin, dedicated to the administration of said dose.", "The packaging is suitable for the storage of at least one dose of the gel or of the composition according to the invention.", "The packaging may be arranged so to allow, moreover, said gel or said composition to be sampled.", "Thus, according to a first embodiment, said packaging is scored so as to allow said gel or said composition to be sampled.", "For example, it may be in the form of an ampoule, a bottle or a capsule, in particular a soft capsule.", "Preferably, the packaging may be single-dose and/or have a scored end.", "According to a second embodiment, said packaging has a cap which allows hermetic sealing during storage and which can be pierced by a needle or cannula at the time of use.", "With regard to the injection device, it may be as previously defined and preferably be disposable.", "Preferably, the injection device is suitable for an intraepidermal and/or intradermal and/or subcutaneous injection.", "Preferentially, said device is suitable for the mesotherapy technique.", "Use According to yet another aspect of the present invention, the latter relates to the use of a crosslinked hyaluronic acid gel or of a composition according to the invention, for preventing and/or treating the cutaneous signs of chronological ageing and/or the cutaneous signs which are induced by external factors such as stress, tobacco and/or prolonged exposure to UV radiation.", "A crosslinked hyaluronic acid gel or a composition according to the invention is also advantageous in that it can be used for preventing and/or treating a modification of the surface appearance of the skin, a modification of the viscoelastic or biomechanical properties of the skin, a decrease in cell energy metabolism, or dehydration of the skin.", "A crosslinked hyaluronic acid gel or a composition according to the invention is again advantageous in that it can be used for filling skin volume defects, in particular wrinkles, and/or restoring the radiance of the skin.", "Treatment Process According to another aspect of the present invention, the latter relates to a cosmetic skin treatment process comprising at least one step of administering, in or through the skin, a crosslinked hyaluronic acid gel or a composition according to the invention.", "According to one particular embodiment, the administration step can be repeated on all or part of the surface to be treated.", "The repetition of the injections makes it possible to create a layering such that the composition according to the invention is distributed homogeneously in the skin region to be treated.", "According to one particular embodiment, the skin regions advantageously treated by means of a process of the invention may be the skin and the lips, and in particular the skin of the face, of the neck, of the neckline, of the hands, of the scalp, of the abdomen and/or of the legs.", "A gel or a composition according to the invention may advantageously be injected at the level of the wrinkles and fine lines.", "There are several injection techniques.", "By way of usable techniques, mention may be made of the “multiple bolus” technique which consists in performing injections in the superficial dermis of on average 0.05 ml of a composition according to the invention, called a bolus, said boluses each being about 1 cm apart.", "This technique is in particular recommended for the face and the neckline.", "Mention may also be made of the “backtracking” technique which consists in performing linear tracking injections in the superficial dermis, in introducing the needle with a 45° angle along the skin depression and then depositing the composition according to the invention in the superficial dermis while gently withdrawing the needle.", "Finally, mention may be made of the “multipuncture” technique which consists in performing a burst of multiple injections of small amounts of composition according to the invention in the epidermis.", "The injection points are very close together, for example approximately every 3 mm, and are distributed uniformly over the surface to be treated or by forming a line along the wrinkle.", "This technique is in particular recommended for unifying the complexion.", "The treatment process in accordance with the invention also proves to be advantageous for preventing and/or treating the cutaneous signs of ageing or of photoageing, in particular chosen from wrinkled skin, skin exhibiting a modification of its viscoelastic or biochemical properties, skin exhibiting a modification in the cohesion of its tissues, thinned skin, skin exhibiting a modification of its surface appearance, slackening of the skin.", "The treatment process in accordance with the present invention also proves to be advantageous for preventing and/or treating a decrease in cell energy metabolism or dehydration of the skin.", "The treatment process in accordance with the present invention also proves to be advantageous for filling skin volume defects, in particular wrinkles, and/or restoring the radiance of the skin.", "The treatment process in accordance with the present invention can preferably be carried out in an epidermal, dermo-epidermal and/or dermal, or even subcutaneous, region.", "Throughout the present application, the expression “comprising a” is synonymous with “comprising at least one” and “between .", ".", ".", "and .", ".", ".", "” and “ranging from .", ".", ".", "to .", ".", ".", "” should be understood to mean limits inclusive.", "The following examples are given by way of nonlimiting illustration of the present invention.", "EXAMPLES Example 1: Protocol for Preparing a Hyaluronic Acid Gel Crosslinked with Spermine as Crosslinking Agent Hyaluronic acid is dissolved at a concentration of 3% (by weight) in water.", "After obtaining a homogeneous solution, a solution containing spermine (the one ≥96% sold by the company Sigma-Aldrich under the name Sigma), EDC as activator (N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride ≥98.0% sold by the company Sigma-Aldrich under the name Fluka) and HOBt as auxiliary coupling agent (1-hydroxybenzotriazole hydrate, ≥97% sold by the company Sigma-Aldrich under the name Aldrich) is added to the hyaluronic acid solution.", "The volume of this solution is defined so as to obtain an overall mixture containing 2.3% of hyaluronic acid.", "The pH of this solution is adjusted so as to obtain a pH of the overall mixture of between 5.5 and 6.5 before reaction, by using a dilute solution of HCl or of NaOH.", "The amounts of reagents are adjusted according to the desired degree of modification.", "They range between 5×10−3 and 2×10−2 mol/mol of hyaluronic acid repeat units for the polyamine, and between 0.5 and 1 mol/mol of hyaluronic acid repeat units for the activator and the auxiliary coupling agent involved in the coupling reaction.", "The stoichiometries used are indicated in the examples given.", "For the crosslinking, the aqueous gel is exposed for 7 to 24 h at 25° C. After crosslinking, the gel obtained is purified by means of several dialysis baths over a period of from 2 to 3 days and, if necessary, adjusted to physiological pH.", "The aqueous gel obtained after washing comprises a hyaluronic acid concentration close to 20 mg/g.", "In order to facilitate the extrusion forces for passing the gel through a needle, noncrosslinked hyaluronic acid is then incorporated into and homogenized in the gel obtained above.", "The sterilization is carried out in an autoclave (wet heat) at T°≥121° C., so as to obtain an F0>15 (sterilizing value).", "Example 2: Preparation of Crosslinked Hyaluronic Acid Gels which are in Accordance with the Invention (with Spermine) and Comparative (with HMDA) Three crosslinked hyaluronic acid gels are prepared on the basis of the protocol defined in Example 1 above.", "For these three gels, n HOBt=n EDC=n HA.", "These three gels differ from one another by virtue of the nature of the polyamine under consideration and/or the “polyamine/hyaluronic acid” ratio, as illustrated in Table 1 hereinafter.", "The final column [HA] indicates the hyaluronic acid concentration of the gels obtained.", "TABLE 1 Crosslinking Stoichiometry: [HA], Gel crosslinked agent n polyamine/n HA mg/g A (comparative) HMDA* 0.100 21 B Spermine 0.020 21 C Spermine 0.010 21 *HMDA = hexamethylenediamine n HOBt = n EDC = n HA 1) Characterization of the Degree of Modification of the Gels a, B and C Sample Preparation Protocol The gels A, B and C are washed/precipitated with isopropanol.", "The solids obtained are dried and then solubilized in D2O, and treated in the presence of hyaluronidase (type VI-S, Sigma, 3kU) in 1 ml of D2O for degradation of the gel, in order to obtain a liquid matrix for analysis.", "The homogeneous mixture obtained is then analysed by 1H NMR.", "Measurement of the Degree of Modification The characterization of the respective degrees of modification to the gels A, B and C is carried out by NMR spectroscopy.", "For the polyamines, the 1H proton peaks for HMDA at 1.34 ppm and for spermine at 1.73 ppm are retained as references.", "The degree of modification of each of the three crosslinked hyaluronic acid gels is then characterized using the integral of these reference peaks according to the following formula: Degree   of   modification = ( Integral   δ H  -  reference X ) ( Integral   δ Acetamide 3 ) X: number of protons of the peak retained for the measurement, i.e.", "4 for spermine and HMDA.", "δ-Acetamide: shift corresponding to the acetamide peak of HA, therefore comprising 3 protons.", "The NMR analysis is carried out on a Bruker Avance 1 spectrometer operating at 400 MHz (1H).", "The various results and observations are summarized in the following Table 2: TABLE 2 Degree of GEL δH-ref (ppm) X modification (%) A (HMDA control) 1.34 4 5.0 B 1.73 4 0.7 C 1.73 4 1.0 It emerges from Table 2 above that the degrees of modification of the crosslinked gels B and C in accordance with the invention are, compared with those of the control gel A, significantly reduced.", "The hyaluronic acid crosslinked with spermine is therefore less modified than the one resulting from the crosslinking with HMDA.", "2) Characterization of the Mechanical Properties a) The viscoelastic properties of the gels A, B and C are characterized via the measurement of their elastic modulus G′ (in Pa) and of their phase angle δ (°), measured at 1 Hz for a stress of 5 Pa. Table 3 hereinafter represents the values measured.", "TABLE 3 Amplitude sweep (cone/plate) G′ (Pa) δ (°) τ (Pa) measured at measured at measured at Gel τ = 5 Pa τ = 5 Pa cross-over A (HMDA 64 48.2 90 control) B 318 10.8 510 C 227 18.1 590 The control gel A, although crosslinked with a polyamine (HMDA), is not sufficient since, although the degree of modification of the hyaluronic acid is high, its mechanical properties are weak.", "Despite a reduced degree of modification, the gels B and C exhibit, on the other hand, a rheological behaviour which is significantly improved compared with the comparative gel A. b) The resistance to sterilization of the gels A, B and C is determined via the characterization of the loss of elastic modulus G′ (in Pa) of these gels after exposure to a sterilization carried out in an autoclave (wet heat) at T°≥121° C., so as to obtain an F0≥15 (sterilizing value).", "Table 4 hereinafter represents the values measured.", "TABLE 4 Amplitude sweep (cone/plate) measured at t = 5 Pa Gel Loss G′ (%) A (HMDA control) 60% B 23% C 24% The control gel A is once again not satisfactory since it exhibits poor resistance to sterilization compared with the gels B and C." ] ]
Patent_15874144
[ [ "ALLOYS FOR HIGHLY SHAPED ALUMINUM PRODUCTS AND METHODS OF MAKING THE SAME", "Described herein are novel aluminum containing alloys.", "The alloys are highly formable and can be used for producing highly shaped aluminum products, including bottles and cans." ], [ "1.A method of producing a metal sheet, comprising: direct chill casting an aluminum alloy to form an ingot, wherein the aluminum alloy comprises about 0.25-0.35 wt.", "% Si, 0.40-0.60 wt.", "% Fe, 0-0.40 wt.", "% Cu, 1.10-1.50 wt.", "% Mn, 0-0.76 wt.", "% Mg, 0.001-0.05 wt.", "% Cr, 0-0.3 wt.", "% Zn, up to 0.15 wt.", "% of impurities, with the remainder as Al; homogenizing the ingot to form an ingot containing a plurality of Mn-containing dispersoids; hot rolling the ingot containing the plurality of Mn-containing dispersoids to produce a metal sheet; and cold rolling the metal sheet.", "2.The method of claim 1, wherein the homogenizing step is a two-stage homogenizing cycle.", "3.The method of claim 2, wherein the two-stage homogenizing cycle comprises: heating the ingot to a peak metal temperature of at least 600° C.; allowing the ingot to stand at the peak metal temperature for four or more hours; cooling the ingot to a temperature of 550° C. or lower; and allowing the ingot to stand for up to 20 hours.", "4.The method of claim 1, wherein the plurality of Mn-containing dispersoids comprises Mn-containing dispersoids each having a diameter of 1 μm or less.", "5.The method of claim 1, wherein the aluminum alloy comprises about 0.25-0.35 wt.", "% Si, 0.40-0.50 wt.", "% Fe, 0.08-0.22 wt.", "% Cu, 1.10-1.30 wt.", "% Mn, 0-0.5 wt.", "% Mg, 0.001-0.03 wt.", "% Cr, 0.07-0.13 wt.", "% Zn, up to 0.15 wt.", "% of impurities, with the remainder as Al.", "6.The method of claim 1, wherein the aluminum alloy comprises about 0.25-0.30 wt.", "% Si, 0.40-0.45 wt.", "% Fe, 0.10-0.20 wt.", "% Cu, 1.15-1.25 wt.", "% Mn, 0-0.25 wt.", "% Mg, 0.003-0.02 wt.", "% Cr, 0.07-0.10 wt.", "% Zn, up to 0.15 wt.", "% of impurities, with the remainder as Al.", "7.The method of claim 1, wherein the aluminum alloy comprises Mg in an amount of 0.10 wt.", "% or less.", "8.The method of claim 1, wherein the aluminum alloy comprises Cr in an amount of 0.001-0.03 wt.", "%.", "9.A product obtained by the method of claim 1.10.The product of claim 9, wherein the product is a bottle.", "11.The product of claim 9, wherein the product is a can." ], [ "<SOH> BACKGROUND <EOH>Formable alloys for use in manufacturing highly shaped cans and bottles are desired.", "For shaped bottles, the manufacturing process typically involves first producing a cylinder using a drawing and wall ironing (DWI) process.", "The resulting cylinder is then formed into a bottle shape using, for example, a sequence of full-body necking steps, blow molding, or other mechanical shaping, or a combination of these processes.", "The demands on any alloy used in such a process or combination of processes are complex.", "Thus, there is a need for alloys capable of sustaining high levels of deformation during mechanical shaping and/or blow molding for the bottle shaping process and that function well in the DWI process used to make the starting cylindrical preform.", "In addition, methods are needed for making preforms from the alloy at high speeds and levels of runnability, such as that demonstrated by the current can body alloy AA3104.AA3104 contains a high volume fraction of coarse intermetallic particles formed during casting and modified during homogenization and rolling.", "These particles play a major role in die cleaning during the DWI process, helping to remove any aluminum or aluminum oxide build-up on the dies, which improves both the metal surface appearance and also the runnability of the sheet.", "The other requirements of the alloy are that it must be possible to produce a bottle which meets the targets for mechanical performance (e.g., column strength, rigidity, and a minimum bottom dome reversal pressure in the final shaped product) with lower weight than the current generation of aluminum bottles.", "The only way to achieve lower weight without significant modification of the design is to reduce the wall thickness of the bottle.", "This makes meeting the mechanical performance requirement even more challenging.", "A final requirement is the ability to form the bottles at a high speed.", "In order to achieve a high throughput (e.g., 500-600 bottles per minute) in commercial production, the shaping of the bottle must be completed in a very short time.", "Thus, the materials will be deformed employing a very high strain rate.", "While aluminum alloys in general are not known to be strain rate sensitive at room temperature, the high temperature formability decreases significantly with increasing strain rate, particularly for Mg-containing alloys.", "As known to those of skill in the art, the increase in fracture elongation associated with increases in forming temperature in a low strain rate regime diminishes progressively with increasing strain rate." ], [ "<SOH> SUMMARY <EOH>Provided herein are novel alloys that display high strain rate formability at elevated temperatures.", "The alloys can be used for producing highly shaped aluminum products, including bottles and cans.", "The aluminum alloy described herein includes about 0.25-0.35% Si, 0.40-0.60% Fe, 0-0.40% Cu, 1.10-1.50% Mn, 0-0.76% Mg, 0.001-0.05% Cr, 0-0.3% Zn, up to 0.15% of impurities, with the remainder as Al (all in weight percentage (wt.", "%)).", "In some embodiments, the aluminum alloy comprises about 0.25-0.35% Si, 0.40-0.50% Fe, 0.08-0.22% Cu, 1.10-1.30% Mn, 0-0.5% Mg, 0.001-0.03% Cr, 0.07-0.13% Zn, up to 0.15% of impurities, with the remainder as Al (all in weight percentage (wt.", "%)).", "In some embodiments, the aluminum alloy comprises about 0.25-0.30% Si, 0.40-0.45% Fe, 0.10-0.20% Cu, 1.15-1.25% Mn, 0-0.25% Mg, 0.003-0.02% Cr, 0.07-0.10% Zn, up to 0.15% of impurities, with the remainder as Al (all in weight percentage (wt.", "%)).", "Optionally, the alloy includes Mg in an amount of 0.10 wt.", "% or less.", "The alloy can include Mn-containing dispersoids, which can each have a diameter of 1 μm or less.", "The alloy can be produced by direct chill casting, homogenizing, hot rolling, and cold rolling.", "In some embodiments, the homogenization step is a two-stage homogenization process.", "Optionally, the method can include a batch annealing step.", "Also provided herein are products (e.g., bottles and cans) comprising the aluminum alloy as described herein.", "Further provided herein are methods of producing a metal sheet.", "The methods include the steps of direct chill casting an aluminum alloy as described herein to form an ingot, homogenizing the ingot to form an ingot containing a plurality of Mn-containing dispersoids, hot rolling the ingot containing the plurality of Mn-containing dispersoids to produce a metal sheet, and cold rolling the metal sheet.", "Optionally, the plurality of Mn-containing dispersoids comprises Mn-containing dispersoids having a diameter of 1 μm or less.", "In some embodiments, the homogenizing step is a two-stage homogenizing process.", "The two-stage homogenizing process can include heating the ingot to a peak metal temperature of at least 600° C., allowing the ingot to stand at the peak metal temperature for four or more hours, cooling the ingot to a temperature of 550° C. or lower, and allowing the final ingot to stand for up to 20 hours.", "Optionally, the method can include a batch annealing step.", "Products (e.g., bottles or cans) obtained according to the methods are also provided herein.", "Other objects and advantages of the invention will be apparent from the following detailed description of embodiments of the invention." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a divisional application of U.S. patent application Ser.", "No.", "14/849,698, filed Sep. 10, 2015, entitled “Alloys for Highly Shaped Aluminum Products and Methods of Making the Same,” which claims the benefit of U.S.", "Provisional Patent Application No.", "62/049,445, filed Sep. 12, 2014, which are incorporated by reference herein in their entireties.", "FIELD OF THE INVENTION The present invention provides a novel alloy.", "In one embodiment, the alloy is a highly formable aluminum alloy.", "The invention further relates to use of the alloy for producing highly shaped aluminum products, including bottles and cans.", "BACKGROUND Formable alloys for use in manufacturing highly shaped cans and bottles are desired.", "For shaped bottles, the manufacturing process typically involves first producing a cylinder using a drawing and wall ironing (DWI) process.", "The resulting cylinder is then formed into a bottle shape using, for example, a sequence of full-body necking steps, blow molding, or other mechanical shaping, or a combination of these processes.", "The demands on any alloy used in such a process or combination of processes are complex.", "Thus, there is a need for alloys capable of sustaining high levels of deformation during mechanical shaping and/or blow molding for the bottle shaping process and that function well in the DWI process used to make the starting cylindrical preform.", "In addition, methods are needed for making preforms from the alloy at high speeds and levels of runnability, such as that demonstrated by the current can body alloy AA3104.AA3104 contains a high volume fraction of coarse intermetallic particles formed during casting and modified during homogenization and rolling.", "These particles play a major role in die cleaning during the DWI process, helping to remove any aluminum or aluminum oxide build-up on the dies, which improves both the metal surface appearance and also the runnability of the sheet.", "The other requirements of the alloy are that it must be possible to produce a bottle which meets the targets for mechanical performance (e.g., column strength, rigidity, and a minimum bottom dome reversal pressure in the final shaped product) with lower weight than the current generation of aluminum bottles.", "The only way to achieve lower weight without significant modification of the design is to reduce the wall thickness of the bottle.", "This makes meeting the mechanical performance requirement even more challenging.", "A final requirement is the ability to form the bottles at a high speed.", "In order to achieve a high throughput (e.g., 500-600 bottles per minute) in commercial production, the shaping of the bottle must be completed in a very short time.", "Thus, the materials will be deformed employing a very high strain rate.", "While aluminum alloys in general are not known to be strain rate sensitive at room temperature, the high temperature formability decreases significantly with increasing strain rate, particularly for Mg-containing alloys.", "As known to those of skill in the art, the increase in fracture elongation associated with increases in forming temperature in a low strain rate regime diminishes progressively with increasing strain rate.", "SUMMARY Provided herein are novel alloys that display high strain rate formability at elevated temperatures.", "The alloys can be used for producing highly shaped aluminum products, including bottles and cans.", "The aluminum alloy described herein includes about 0.25-0.35% Si, 0.40-0.60% Fe, 0-0.40% Cu, 1.10-1.50% Mn, 0-0.76% Mg, 0.001-0.05% Cr, 0-0.3% Zn, up to 0.15% of impurities, with the remainder as Al (all in weight percentage (wt.", "%)).", "In some embodiments, the aluminum alloy comprises about 0.25-0.35% Si, 0.40-0.50% Fe, 0.08-0.22% Cu, 1.10-1.30% Mn, 0-0.5% Mg, 0.001-0.03% Cr, 0.07-0.13% Zn, up to 0.15% of impurities, with the remainder as Al (all in weight percentage (wt.", "%)).", "In some embodiments, the aluminum alloy comprises about 0.25-0.30% Si, 0.40-0.45% Fe, 0.10-0.20% Cu, 1.15-1.25% Mn, 0-0.25% Mg, 0.003-0.02% Cr, 0.07-0.10% Zn, up to 0.15% of impurities, with the remainder as Al (all in weight percentage (wt.", "%)).", "Optionally, the alloy includes Mg in an amount of 0.10 wt.", "% or less.", "The alloy can include Mn-containing dispersoids, which can each have a diameter of 1 μm or less.", "The alloy can be produced by direct chill casting, homogenizing, hot rolling, and cold rolling.", "In some embodiments, the homogenization step is a two-stage homogenization process.", "Optionally, the method can include a batch annealing step.", "Also provided herein are products (e.g., bottles and cans) comprising the aluminum alloy as described herein.", "Further provided herein are methods of producing a metal sheet.", "The methods include the steps of direct chill casting an aluminum alloy as described herein to form an ingot, homogenizing the ingot to form an ingot containing a plurality of Mn-containing dispersoids, hot rolling the ingot containing the plurality of Mn-containing dispersoids to produce a metal sheet, and cold rolling the metal sheet.", "Optionally, the plurality of Mn-containing dispersoids comprises Mn-containing dispersoids having a diameter of 1 μm or less.", "In some embodiments, the homogenizing step is a two-stage homogenizing process.", "The two-stage homogenizing process can include heating the ingot to a peak metal temperature of at least 600° C., allowing the ingot to stand at the peak metal temperature for four or more hours, cooling the ingot to a temperature of 550° C. or lower, and allowing the final ingot to stand for up to 20 hours.", "Optionally, the method can include a batch annealing step.", "Products (e.g., bottles or cans) obtained according to the methods are also provided herein.", "Other objects and advantages of the invention will be apparent from the following detailed description of embodiments of the invention.", "BRIEF DESCRIPTION OF THE FIGURES FIG.", "1A is a photograph showing the recrystallized grain structure of Mn-containing dispersoid samples that were homogenized using the conventional low temperature cycle at approximately 540° C. FIG.", "1B is a photograph showing the recrystallized grain structure of Mn-containing dispersoid samples that were homogenized at 600° C. for 8 hours.", "FIG.", "2A is a graph showing the total tensile elongation, at a strain rate of 0.58 s−1, for the prototype alloys described herein and for comparison alloys.", "In FIG.", "2A, “3104” represents comparison alloy AA3104 and “LC,” “H2,” “0.2Mg,” and “0.5Mg” represent the prototype alloys.", "FIG.", "2B is a graph showing the total tensile elongation, at a strain rate of 0.058 s−1, for the prototype alloys described herein and for comparison alloys.", "In FIG.", "2B, “3104” represents comparison alloy AA3104 and “LC,” “H2,” “0.2Mg,” and “0.5Mg” represent the prototype alloys.", "DETAILED DESCRIPTION In the commercial manufacturing of aluminum cans and bottles, the shaping processes of the materials should be carried out at a high speed to achieve the throughput required to make the process economically feasible.", "Furthermore, the application of elevated temperature during forming may be required to form containers with more complicated shapes and larger, expanded diameters, as desired by brand owners and consumers.", "Hence, it is imperative that the materials used for such application are capable of achieving high formability when deformed at high strain rates and elevated temperatures.", "During warm forming, two important microstructural processes occur concurrently: recovery and work hardening.", "However, the two processes impose opposite effects on the total dislocation density of the materials.", "While the recovery process reduces the dislocation density in the matrix by reorganizing the dislocation configuration, work hardening increases the dislocation density by generating new dislocations.", "When the rates of the two processes reach the same magnitude, the elongation of the materials is greatly enhanced.", "Definitions and Descriptions The terms “invention,” “the invention,” “this invention” and “the present invention” used herein are intended to refer broadly to all of the subject matter of this patent application and the claims below.", "Statements containing these terms should be understood not to limit the subject matter described herein or to limit the meaning or scope of the patent claims below.", "In this description, reference is made to alloys identified by AA numbers and other related designations, such as “series.” For an understanding of the number designation system most commonly used in naming and identifying aluminum and its alloys, see “International Alloy Designations and Chemical Composition Limits for Wrought Aluminum and Wrought Aluminum Alloys” or “Registration Record of Aluminum Association Alloy Designations and Chemical Compositions Limits for Aluminum Alloys in the Form of Castings and Ingot,” both published by The Aluminum Association.", "As used herein, the meaning of “a,” “an,” and “the” includes singular and plural references unless the context clearly dictates otherwise.", "In the following embodiments, the aluminum alloys are described in terms of their elemental composition in weight percent (wt.", "%).", "In each alloy, the remainder is aluminum, with a maximum wt.", "% of 0.15% for the sum of all impurities.", "Alloy Composition Described herein is a new aluminum alloy which exhibits good high strain rate formability at elevated temperatures (e.g., at temperatures up to 250° C.).", "As used herein, “high strain rate” refers to a strain rate of at least 0.5 s−1.For example, a high strain rate can be at least 0.5 s−1, at least 0.6 s−1, at least 0.7 s−1, at least 0.8 s−1, or at least 0.9 s−1.The alloy compositions described herein are aluminum-containing alloy compositions.", "The alloy compositions exhibit good high strain rate formability at elevated temperatures.", "The high strain rate formability is achieved due to the elemental compositions of the alloys.", "Specifically, an alloy as described herein can have the following elemental composition as provided in Table 1.The components of the composition are provided in terms of weight percentage (wt.", "%) based on the total weight of the alloy.", "TABLE 1 Element Weight Percentage (wt.", "%) Si 0.25-0.35 Fe 0.40-0.60 Cu 0-0.40 Mn 1.10-1.50 Mg 0-0.76 Cr 0.001-0.05 Zn 0-0.3 Ti 0-0.10 Others 0-0.03 (each) 0-0.15 (total) Al Remainder In some embodiments, the alloy as described herein can have the following elemental composition as provided in Table 2.The components of the composition are provided in terms of weight percentage (wt.", "%) based on the total weight of the alloy.", "TABLE 2 Element Weight Percentage (wt.", "%) Si 0.25-0.35 Fe 0.40-0.50 Cu 0.08-0.22 Mn 1.10-1.30 Mg 0-0.50 Cr 0.001-0.03 Zn 0.07-0.13 Ti 0-0.10 Others 0-0.03 (each) 0-0.15 (total) Al Remainder In some embodiments, the alloy as described herein can have the following elemental composition as provided in Table 3.The components of the composition are provided in terms of weight percentage (wt.", "%) based on the total weight of the alloy.", "TABLE 3 Element Weight Percentage (wt.", "%) Si 0.25-0.30 Fe 0.40-0.45 Cu 0.10-0.20 Mn 1.15-1.25 Mg 0-0.25 Cr 0.003-0.02 Zn 0.07-0.10 Ti 0-0.10 Others 0-0.03 (each) 0-0.15 (total) Al Remainder In some embodiments, the alloy described herein includes silicon (Si) in an amount of from 0.25% to 0.35% (e.g., from 0.25% to 0.30% or from 0.27% to 0.30%) based on the total weight of the alloy.", "For example, the alloy can include 0.25%, 0.26%, 0.27%, 0.28%, 0.29%, 0.30%, 0.31%, 0.32%, 0.33%, 0.34%, or 0.35% Si.", "All expressed in wt.", "%.", "In some embodiments, the alloy described herein also includes iron (Fe) in an amount of from 0.40% to 0.60% (e.g., from 0.40% to 0.5% or from 0.40% to 0.45%) based on the total weight of the alloy.", "For example, the alloy can include 0.40%, 0.41%, 0.42%, 0.43%, 0.44%, 0.45%, 0.46%, 0.47%, 0.48%, 0.49%, 0.50%, 0.51%, 0.52%, 0.53%, 0.54%, 0.55%, 0.56%, 0.57%, 0.58%, 0.59%, or 0.60% Fe.", "All expressed in wt.", "%.", "In some embodiments, the alloy described includes copper (Cu) in an amount of up to 0.40% (e.g., from 0.08% to 0.22% or from 0.10% to 0.20%) based on the total weight of the alloy.", "For example, the alloy can include 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.10%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, 0.20%, 0.21%, 0.22%, 0.23%, 0.24%, 0.25%, 0.26%, 0.27%, 0.28%, 0.29%, 0.30%, 0.31%, 0.32%, 0.33%, 0.34%, 0.35%, 0.36%, 0.37%, 0.38%, 0.39%, or 0.40% Cu.", "In some embodiments, Cu is not present in the alloy (i.e., 0%).", "All expressed in wt.", "%.", "In some embodiments, the alloy described herein can include manganese (Mn) in an amount of from 1.10% to 1.50% (e.g., from 1.10% to 1.30% or from 1.15% to 1.25%) based on the total weight of the alloy.", "For example, the alloy can include 1.10%, 1.11%, 1.12%, 1.13%, 1.14%, 1.15%, 1.16%, 1.17%, 1.18%, 1.19%, 1.20%, 1.21%, 1.22%, 1.23%, 1.24%, 1.25%1.26%1.27%1.28%1.29%1.30%1.31%1.32%1.33%1.34%1.35%, 1.36%, 1.37%, 1.38%, 1.39%, 1.40%, 1.41%, 1.42%, 1.43%, 1.44%, 1.45%, 1.46%, 1.47%, 1.48%, 1.49%, or 1.50% Mn.", "All expressed in wt.", "%.", "The inclusion of Mn in the alloys described herein in an amount of from 1.10% to 1.50% is referred to as a “high Mn content.” As described further below and as demonstrated in the Examples, the high Mn content results in the desired precipitation of fine Mn-containing dispersoids during the homogenization cycle.", "The high Mn content has a two-fold effect on the properties of the materials.", "First, a high Mn content results in a high strength alloy.", "Mn is a solid solution or precipitation hardening element in aluminum.", "Higher Mn content in the solid solution results in a higher strength of the final alloy.", "Second, a high Mn content results in an alloy with high formability properties.", "Specifically, Mn atoms combine with Al and Fe atoms to form dispersoids (i.e., Mn-containing dispersoids) during the homogenization cycle.", "Without being bound by theory, these fine and homogeneously distributed dispersoids pin grain boundaries during recrystallization, which allows the refinement of grain size and the formation of a more uniform microstructure.", "During recrystallization, grain boundaries are attracted to these fine Mn-containing dispersoids because when a grain boundary intersects a particle, a region of the boundary equal to the intersection area is effectively removed.", "In turn, a reduction in the free energy of the overall system is achieved.", "In addition to refining grain size, the fine Mn-containing dispersoids improve the material's resistance to grain boundary failure by reducing the dislocation slip band spacing.", "The fine Mn-containing dispersoids also reduce the tendency to form intense shear bands during deformation.", "As a consequence of these positive effects of the Mn-containing dispersoids, the overall formability of the materials is improved.", "Magnesium (Mg) can be included in the alloys described herein to attain a desired strength requirement.", "However, in the alloys described herein, the total elongation of the materials is significantly improved by controlling the Mg content to an acceptable limit.", "Optionally, the alloy described herein can include Mg in an amount of up to 0.76% (e.g., up to 0.5% or up to 0.25%).", "In some embodiments, the alloy can include 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, 0.2%, 0.21%, 0.22%, 0.23%, 0.24%, 0.25%, 0.26%, 0.27%0.28%0.29%, 0.3%, 0.31%, 0.32%, 0.33%, 0.34%, 0.35%, 0.36%, 0.37%, 0.38%, 0.39%, 0.4%, 0.41%, 0.42%, 0.43%, 0.44%, 0.45%, 0.46%, 0.47%, 0.48%, 0.49%, 0.5%, 0.51%, 0.52%, 0.53%, 0.54%, 0.55%, 0.56%, 0.57%, 0.58%, 0.59%, 0.6%, 0.61%, 0.62%, 0.63%, 0.64%, 0.65%, 0.66%, 0.67%, 0.68%, 0.69%, 0.7%, 0.71%, 0.72%, 0.73%, 0.74%, 0.75%, or 0.76% Mg.", "In some embodiments, the alloy described herein can include less than 0.76% Mg. For example, in some embodiments, Mg is present in an amount of 0.5% Mg or less.", "In some embodiments, Mg is present in an amount of 0.25% or less, 0.20% or less, 0.15% or less, 0.10% or less, 0.05% or less or 0.01% or less.", "In some embodiments, Mg is not present in the alloy (i.e., 0%).", "All expressed in wt.", "%.", "The inclusion of Mg in the alloys described herein in an amount of up to 0.50% (e.g., up to 0.25%) is referred to as a “low Mg content.” As described further below and as demonstrated in the Examples, the low Mg content results in the desired high strain rate formability at elevated temperatures (e.g., at temperatures of up to 250° C.) and an improved elongation of the materials.", "In some embodiments, the alloy described herein includes chromium (Cr) in an amount of from 0.001% to 0.05% (e.g., from 0.001% to 0.03% or from 0.003% to 0.02%) based on the total weight of the alloy.", "For example, the alloy can include 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.011%, 0.012%, 0.013%, 0.014%, 0.015%, 0.016%, 0.017%, 0.018%, 0.019%, 0.02%, 0.021%, 0.022%, 0.023%, 0.024%, 0.025%, 0.026%, 0.027%, 0.028%, 0.029%, 0.03%, 0.031%, 0.032%, 0.033%, 0.034%, 0.035%, 0.036%, 0.037%, 0.038%, 0.039%, 0.04%, 0.041%, 0.042%, 0.043%, 0.044%, 0.045%, 0.046%, 0.047%, 0.048%, 0.049%, or 0.05% Cr.", "All expressed in wt.", "%.", "In some embodiments, the alloy described herein includes zinc (Zn) in an amount of up to 0.30% (e.g., from 0.07% to 0.30%, from 0.05% to 0.13%, or from 0.07% to 0.10%) based on the total weight of the alloy.", "For example, the alloy can include 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.10%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, 0.2%, 0.21%, 0.22%, 0.23%, 0.24%, 0.25%, 0.26%, 0.27%, 0.28%, 0.29%, or 0.3% Zn.", "In some embodiments, Zn is not present in the alloy (i.e., 0%).", "All expressed in wt.", "%.", "In some embodiments, the alloy described herein includes titanium (Ti) in an amount of up to 0.10% (e.g., from 0% to 0.10%, from 0.01% to 0.09%, or from 0.03% to 0.07%) based on the total weight of the alloy.", "For example, the alloy can include 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, or 0.10% Ti.", "In some embodiments, Ti is not present in the alloy (i.e., 0%).", "All expressed in wt.", "%.", "Optionally, the alloy compositions described herein can further include other minor elements, sometimes referred to as impurities, in amounts of 0.03% or below, 0.02% or below, or 0.01% or below, each.", "These impurities may include, but are not limited to, V, Zr, Ni, Sn, Ga, Ca, or combinations thereof.", "Accordingly, V, Zr, Ni, Sn, Ga, or Ca may each be present in alloys in amounts of 0.03% or below, 0.02% or below, or 0.01% or below.", "In general, the impurity levels are below 0.03% for V and below 0.01% for Zr.", "In some embodiments, the sum of all impurities does not exceed 0.15% (e.g., 0.10%).", "All expressed in wt.", "%.", "The remaining percentage of the alloy is aluminum.", "Methods of Making The alloys described herein can be cast into ingots using a Direct Chill (DC) process.", "The DC casting process is performed according to standards commonly used in the aluminum industry as known to one of ordinary skill in the art.", "In some embodiments, to achieve the desired microstructure, mechanical properties (e.g., high formability), and physical properties of the products, the alloys are not processed using continuous casting methods.", "The cast ingot can then be subjected to further processing steps to form a metal sheet.", "In some embodiments, the processing steps include subjecting the metal ingot to a two-step homogenization cycle, a hot rolling step, an annealing step, and a cold rolling step.", "The homogenization is carried out in two stages to precipitate Mn-containing dispersoids.", "In the first stage, an ingot prepared from the alloy compositions described herein is heated to attain a peak metal temperature of at least 575° C.", "(e.g., at least 600° C., at least 625° C., at least 650° C., or at least 675° C.).", "The ingot is then allowed to soak (i.e., held at the indicated temperature) for a period of time during the first stage.", "In some embodiments, the ingot is allowed to soak for up to 10 hours (e.g., for a period of from 30 minutes to 10 hours, inclusively).", "For example, the ingot can be soaked at the temperature of at least 575° C. for 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, or 10 hours.", "In the second stage, the ingot can be cooled to a temperature lower than the temperature used in the first stage.", "In some embodiments, the ingot can be cooled to a temperature of 550° C. or lower.", "For example, the ingot can be cooled to a temperature of from 400° C. to 550° C. or from 450° C. to 500° C. The ingot can then be soaked for a period of time during the second stage.", "In some embodiments, the ingot is allowed to soak for up to 20 hours (e.g., 1 hour or less, 2 hours or less, 3 hours or less, 4 hours or less, 5 hours or less, 6 hours or less, 7 hours or less, 8 hours or less, 9 hours or less, 10 hours or less, 11 hours or less, 12 hours or less, 13 hours or less, 14 hours or less, 15 hours or less, 16 hours or less, 17 hours or less, 18 hours or less, 19 hours or less, or 20 hours or less).", "The two-step homogenization cycle results in the precipitation of Mn-containing dispersoids.", "Optionally, the Mn-containing dispersoids have a diameter of 1 μm or less.", "For example, the diameter of the Mn-containing dispersoids can be 1 μm or less, 0.9 μm or less, 0.8 μm or less, 0.7 μm or less, 0.6 μm or less, 0.5 μm or less, 0.4 μm or less, 0.3 μm or less, 0.2 μm or less, or 0.1 μm or less.", "Optionally, the Mn-containing dispersoids are homogenously dispersed throughout in the aluminum matrix.", "The Mn-containing dispersoids precipitated according to the size and distribution described herein can control grain size during subsequent steps, such as during recrystallization annealing.", "Following the two-step homogenization cycle, a hot rolling step can be performed.", "In some embodiments, the ingots can be hot rolled to a 5 mm thick gauge or less.", "For example, the ingots can be hot rolled to a 4 mm thick gauge or less, 3 mm thick gauge or less, 2 mm thick gauge or less, or 1 mm thick gauge or less.", "To obtain an appropriate balance of texture in the final materials, the hot rolling speed and temperature can be controlled such that full recrystallization (i.e., the self-annealing) of the hot rolled materials is achieved during coiling at the exit of the tandem mill.", "For self-annealing to occur, the exit temperature is controlled to at least 300° C. Alternatively, batch annealing of the hot rolled coils can be carried out at a temperature of from 350° C. to 450° C. for a period of time.", "For example, batch annealing can be performed for a soak time of up to 1 hour.", "In this process, the hot rolling speed and temperature are controlled during the coiling at the exit of the hot tandem mill.", "In some embodiments, no self-annealing occurs.", "In some embodiments, the hot rolled coils can then be cold rolled to a final gauge thickness of from 0.1 mm-1.0 mm (e.g., from 0.2 mm-0.9 mm or from 0.3 mm-0.8 mm).", "In some embodiments, the cold rolling step can be carried out using the minimum number of cold rolling passes.", "For example, the cold rolling step can be carried out using two cold rolling passes to achieve the desired final gauge.", "In some embodiments, a heat treatment step is not performed before or after the cold rolling process.", "The methods described herein can be used to prepare highly shaped cans and bottles.", "The cold rolled sheets described above can be subjected to a series of conventional can and bottle making processes to produce preforms.", "The preforms can then be annealed to form annealed preforms.", "Optionally, the preforms are prepared from the aluminum alloys using a drawing and wall ironing (DWI) process and the cans and bottles are made according to other shaping processes as known to those of ordinary skill in the art.", "The following examples will serve to further illustrate the present invention without, at the same time, however, constituting any limitation thereof.", "On the contrary, it is to be clearly understood that resort may be had to various embodiments, modifications and equivalents thereof which, after reading the description herein, may suggest themselves to those skilled in the art without departing from the spirit of the invention.", "EXAMPLES Example 1 Alloys were prepared according to the present invention and were homogenized using either the two-step homogenization cycle described herein or the conventional low temperature cycle (i.e., at approximately 540° C.).", "A recrystallized grain structure was established in each sample using a recrystallization annealing process.", "The recrystallized grain structure of the sample homogenized in accordance to the two step homogenization cycle described above is shown in FIG.", "1b.", "The recrystallized grain size of the sample homogenized using the conventional low temperature cycle (i.e., at approximately 540° C.) is shown in FIG.", "1a.", "By comparison, the grain size is significantly finer using the homogenization cycle according to the present invention (i.e., according to the two-step homogenization cycle).", "Thus, the Mn-containing dispersoids controlled the grain size in the sample during subsequent recrystallization annealing.", "The finer grain size retarded the material's tendency to form orange peel after drawing and wall ironing (DWI) and during subsequent expansion processes, such as blow molding.", "Orange peel formation is an undesirable surface defect known to one of ordinary skill in the art.", "Example 2 Five alloys, including Alloy H2, Alloy LC, Alloy 0.2Mg, and Alloy 0.5Mg, were prepared or obtained for tensile elongation testing (see Table 4).", "Alloy AA3104 is the conventionally used can body stock alloy, such as the can body stock commercially available from Novelis, Inc. (Atlanta, Ga.).", "Alloy H2, Alloy LC, Alloy 0.2Mg, and Alloy 0.5Mg are prototype alloys prepared for the tensile tests.", "Alloy H2, Alloy LC, Alloy 0.2Mg, and Alloy 0.5Mg were prepared using a two-step homogenization cycle as described herein.", "Specifically, the ingots having the alloy composition shown below in Table 4 were heated to 615° C. and soaked for 4 hours.", "The ingots were then cooled to 480° C. and soaked at that temperature for 14 hours to result in Mn-containing dispersoids.", "The ingots were then hot rolled to a 2 mm thick gauge followed by a batch annealing cycle at 415° C. for 1 hour.", "Cold rolling was then carried out using two cold rolling passes to a final gauge thickness of approximately 0.45 mm (overall gauge reduction by 78.8%).", "The elemental compositions of the tested alloys are shown in Table 4, with the balance being aluminum.", "The elemental compositions are provided in weight percentages.", "TABLE 4 Alloy Si Fe Cu Mn Mg Cr Zn Ti AA3104 0.30 0.50 0.17 0.86 1.13 0.003 0.14 0.011 H2 0.27 0.42 0.14 1.21 0.01 0.02 0.08 0.011 LC 0.29 0.42 0.10 1.10 0.01 0.02 0.09 0.01 0.2 Mg 0.27 0.41 0.19 1.10 0.20 0.01 0.07 0.009 0.5 Mg 0.30 0.47 0.20 1.22 0.48 0.02 0.10 0.04 Tensile elongation data were obtained for each alloy from Table 4.The high temperature tensile tests were carried out in an Instron tensile machine (Norwood, Mass.)", "equipped with a heating oven.", "The tensile elongation data obtained from the three prototype alloys and AA3104 were compared, as shown in FIGS.", "2a and 2b.", "The data obtained from the conventional can body stock 3104 was included as a baseline comparison.", "All alloys were in their 0-tempered conditions prior to tensile testing.", "FIGS.", "2a and 2b show the elongation data from tests using strain rates of 0.58 s−1 and 0.058 s−1, respectively.", "Alloy AA3104, which contains approximately 1.13 wt.", "% of Mg, showed poor formability when deformed at the higher strain rate at both ambient temperature and at 200° C., as compared to the three prototype alloys.", "At the higher strain rate of 0.58 s−1, the elongations of Alloy LC and Alloy H2, which each contain 0.01 wt.", "% Mg, were increased by increasing the temperature from ambient temperature to 200° C. See FIG.", "2a.", "However, elongation increases were not observed in the three alloys that contained higher amounts of Mg (i.e., Alloy AA3104, Alloy 0.2Mg, and Alloy 0.5Mg).", "Comparing Alloy H2 to Alloy 0.2Mg and Alloy 0.5Mg shows that the addition of 0.2 wt.", "% and 0.5 wt.", "% of Mg retarded the increase in formability associated with the increase in forming temperature (see FIG.", "2a).", "All four prototype alloys, i.e., Alloy LC, Alloy H2, Alloy 0.2Mg, and Alloy 0.5Mg tended to show higher total elongation than AA3104 alloys at both low and high strain rates.", "The addition of Mg significantly reduced the high temperature formability of the alloys when the forming operation was carried out at a higher strain rate, which is an unexpected effect resulting from Mg addition.", "Example 3 To illustrate the superior high strain rate formability of the H2 and LC alloys at elevated temperatures, blow forming experiments were performed using Alloy H2, Alloy LC, and Alloy 0.2Mg from Example 2 above.", "The as-cold rolled sheets were subjected to a series of conventional can making processes, using cuppers and body makers, to produce preforms.", "The preforms were then subjected to an annealing operation.", "The annealed preforms were tested in a blow forming apparatus to evaluate the high strain rate formability of the materials at elevated temperatures.", "The blow forming experiments were conducted at 250° C. The strain rate the materials were subjected to during the forming process was approximately 80 s−1.The results are summarized in Table 5 and provided in terms of the maximum percent expansion, which is the ratio between the original diameter of the preforms and the final diameter of the containers after blow forming.", "TABLE 5 Alloys Maximum percent expansion ratio LC 40% H2 40% 0.2Mg 30% The superior formability of LC and H2 alloys (having low Mg contents) is observed by comparing the results shown in Table 5.Specifically, both alloys achieved a 40% expansion without premature failure.", "In contrast, the maximum expansion ratio of the 0.2Mg alloys was only 30%.", "All patents, patent applications, publications, and abstracts cited above are incorporated herein by reference in their entirety.", "Various embodiments of the invention have been described in fulfillment of the various objectives of the invention.", "It should be recognized that these embodiments are merely illustrative of the principles of the present invention.", "Numerous modifications and adaptations thereof will be readily apparent to those of skill in the art without departing from the spirit and scope of the invention as defined in the following claims." ] ]
Patent_15874146
[ [ "Integrated Pixel Display and Touch Sensor", "In one embodiment, an apparatus includes a display component, a touch sensor component, and a touch-screen controller.", "The display component includes pixel-drive electrodes configured to display an image and the touch sensor component is configured to detect a touch input.", "The touch-screen controller, which is coupled to the touch sensor component, the display component, and the pixel-drive electrodes, is configured to generate a drive signal for the touch sensor component using the pixel-drive electrodes.", "The touch-screen controller is further configured to generate a pixel-chive signal for the display component using the pixel-drive electrodes." ], [ "1-20.", "(canceled) 21.An apparatus, comprising: a display component comprising pixel-drive electrodes configured to display an image; a touch sensor component configured to detect a touch input; a touch-screen controller coupled to the touch sensor component, the display component, and the pixel-drive electrodes, the touch-screen controller configured to: generate a drive signal for the touch sensor component using the pixel-drive electrodes; and generate a pixel-drive signal for the display component using the pixel-drive electrodes.", "22.The apparatus of claim 21, wherein the display component comprises an organic light emitting diode.", "23.The apparatus of claim 21, wherein the display component comprises one or more display layers of a liquid crystal display.", "24.The apparatus of claim 21, wherein the touch-screen controller is coupled to a reference voltage layer, the reference voltage layer configured to provide a reference voltage for the display component and a sense signal to the touch-screen controller.", "25.The apparatus of claim 21, wherein.", "the pixel-drive electrodes comprise a two-dimensional array of pixel-drive electrodes.", "26.The apparatus of claim 21, Wherein the touch-screen controller is separately connected to each of the pixel-drive electrodes.", "27.The apparatus of claim 21, wherein the pixel-drive electrodes are grouped into subsets of pixel-drive electrodes to form drive electrodes.", "28.A controller comprising: a processor; and a memory comprising logic operable, when executed by the processor, to: generate a drive signal for a touch sensor component of a touch screen using pixel-drive electrodes; detect a touch input using the touch sensor component; generate a pixel-drive signal for a display component of the touch screen using the pixel-drive electrodes; and display an image using the display component, the display component comprising the pixel-drive electrodes; wherein the controller is coupled to the touch sensor component, the display component, and the pixel-drive electrodes.", "29.The controller of claim 28, wherein the display component comprises an organic light emitting diode.", "30.The controller of claim 28, wherein the display component comprises one or more display layers of a liquid crystal display.", "31.The controller of claim 28, wherein the controller is further coupled to a reference voltage layer, the reference voltage layer configured to provide a reference voltage for the display component and a sense signal to the controller.", "32.The controller of claim 28, wherein the pixel-drive electrodes comprise a two-dimensional array of pixel-drive electrodes.", "33.The controller of claim 28, wherein the controller is separately connected to each of the pixel-drive electrodes.", "28.The controller of claim 28, wherein the pixel-drive electrodes are grouped into subsets of pixel-drive electrodes to form drive electrodes.", "35.A method comprising: generating a drive signal for a touch sensor component of a touch screen using pixel-drive electrodes; detecting a touch input using the touch sensor component; generating a pixel-drive signal for a display component of the touch screen using the pixel-drive electrodes; and displaying an image using the display component, the display component comprising the pixel-drive electrodes.", "35.The method of claim 35, wherein the display component comprises an organic light emitting diode.", "37.The method of claim 35, wherein the display component comprises one or more display layers of a liquid crystal display.", "38.The method of claim 35, further comprising providing a reference voltage for the display component.", "39.The method of claim 35, wherein the pixel-drive electrodes comprise a two-dimensional array of pixel-drive electrodes.", "40.The method of claim 35, wherein the pixel-drive electrodes are grouped into subsets of pixel-drive electrodes to form drive electrodes." ], [ "<SOH> BACKGROUND <EOH>A touch sensor may detect the presence and location of a touch or the proximity of an object (such as a user's finger or a stylus) within a touch-sensitive area of the touch sensor overlaid on a display screen, for example.", "In a touch-sensitive-display application, the touch sensor may enable a user to interact directly with what is displayed on the screen, rather than indirectly with a mouse or touch pad.", "A touch sensor may be attached to or provided as part of a desktop computer, laptop computer, tablet computer, personal digital assistant (PDA), smartphone, satellite navigation device, portable media player, portable game console, kiosk computer, point-of-sale device, or other suitable device.", "A control panel on a household or other appliance may include a touch sensor.", "There are a number of different types of touch sensors, such as (for example) resistive touch screens, surface acoustic wave touch screens, and capacitive touch screens.", "Herein, reference to a touch sensor may encompass a touch screen, and vice versa, where appropriate.", "When an object touches or comes within proximity of the surface of the capacitive touch screen, a change in capacitance may occur within the touch screen at the location of the touch or proximity.", "A touch-sensor controller may process the change in capacitance to determine its position on the touch screen." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 illustrates an example touch sensor with an example controller.", "FIG.", "2 illustrates a profile view of a portion of an example touch screen in which a pixel layer provides a pixel-drive signal to a display layer of a LCD, and a reference voltage layer provides the display layer of the LCD with a reference voltage and provides an integrated touch sensor with a drive signal.", "FIG.", "3 illustrates a profile view of a portion of an example touch screen in which a pixel-drive layer provides a pixel-drive signal to a display layer of a LCD and a drive signal to an integrated touch sensor, and a reference voltage layer provides a reference voltage for the display layer of the LCD and provides a sense signal to a touch screen controller.", "FIG.", "4 illustrates an overhead view of an example touch screen in which pixel-drive electrodes provide a display portion of a touch screen with a pixel-drive signal and provide an integrated touch sensor of the touch screen with a drive signal.", "FIG.", "5 illustrates an overhead view of an example touch screen in which a reference voltage layer provides a display portion of a touch screen with a reference voltage and provides an integrated touch sensor of the touch screen with a drive signal.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "TECHNICAL FIELD This disclosure generally relates to integrated pixel displays and touch sensors.", "BACKGROUND A touch sensor may detect the presence and location of a touch or the proximity of an object (such as a user's finger or a stylus) within a touch-sensitive area of the touch sensor overlaid on a display screen, for example.", "In a touch-sensitive-display application, the touch sensor may enable a user to interact directly with what is displayed on the screen, rather than indirectly with a mouse or touch pad.", "A touch sensor may be attached to or provided as part of a desktop computer, laptop computer, tablet computer, personal digital assistant (PDA), smartphone, satellite navigation device, portable media player, portable game console, kiosk computer, point-of-sale device, or other suitable device.", "A control panel on a household or other appliance may include a touch sensor.", "There are a number of different types of touch sensors, such as (for example) resistive touch screens, surface acoustic wave touch screens, and capacitive touch screens.", "Herein, reference to a touch sensor may encompass a touch screen, and vice versa, where appropriate.", "When an object touches or comes within proximity of the surface of the capacitive touch screen, a change in capacitance may occur within the touch screen at the location of the touch or proximity.", "A touch-sensor controller may process the change in capacitance to determine its position on the touch screen.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates an example touch sensor with an example controller.", "FIG.", "2 illustrates a profile view of a portion of an example touch screen in which a pixel layer provides a pixel-drive signal to a display layer of a LCD, and a reference voltage layer provides the display layer of the LCD with a reference voltage and provides an integrated touch sensor with a drive signal.", "FIG.", "3 illustrates a profile view of a portion of an example touch screen in which a pixel-drive layer provides a pixel-drive signal to a display layer of a LCD and a drive signal to an integrated touch sensor, and a reference voltage layer provides a reference voltage for the display layer of the LCD and provides a sense signal to a touch screen controller.", "FIG.", "4 illustrates an overhead view of an example touch screen in which pixel-drive electrodes provide a display portion of a touch screen with a pixel-drive signal and provide an integrated touch sensor of the touch screen with a drive signal.", "FIG.", "5 illustrates an overhead view of an example touch screen in which a reference voltage layer provides a display portion of a touch screen with a reference voltage and provides an integrated touch sensor of the touch screen with a drive signal.", "DESCRIPTION OF EXAMPLE EMBODIMENTS FIG.", "1 illustrates an example touch sensor 10 with an example touch-sensor controller 12.Touch sensor 10 and touch-sensor controller 12 may detect the presence and location of a touch or the proximity of an object within a touch-sensitive area of touch sensor 10.Herein, reference to a touch sensor may encompass both the touch sensor and its touch-sensor controller, where appropriate.", "Similarly, reference, to a touch-sensor controller may encompass both the touch-sensor controller and its touch sensor, where appropriate.", "Touch sensor 10 may include one or more touch-sensitive areas, where appropriate.", "Touch sensor 10 may include an array of drive and sense electrodes (or an array of electrodes of a single type) disposed on one or more substrates, which may be made of a dielectric material and/or may be included in a display stack.", "Herein, reference to a touch sensor may encompass both the electrodes of the touch sensor and the substrate(s) that they are disposed on, where appropriate.", "Alternatively, where appropriate, reference to a touch sensor may encompass the electrodes of the touch sensor, but not the substrate(s) that they are disposed on.", "An electrode (whether a drive electrode or a sense electrode) may be an area of conductive material forming a shape, such as for example a disc, square, rectangle, thin line, other suitable shape, or suitable combination of these.", "One or more cuts in one or more layers of conductive material may (at least in part) create the shape of an electrode, and the area of the shape may (at least in part) be bounded by those cuts.", "In particular embodiments, the conductive material of an electrode may occupy approximately 100% of the area of its shape.", "As an example and not by way of limitation, an electrode may be made of indium tin oxide (ITO) and the no of the electrode may occupy approximately 100% of the area of its shape (sometimes referred to as 100% fill), where appropriate.", "In particular embodiments, the conductive material of an electrode may occupy substantially less than 100% of the area of its shape.", "As an example and not by way of limitation, an electrode may he made of fine lines of metal or other conductive material (FLM) such as for example copper, silver, or a copper- or silver-based material and the fine lines of conductive material may occupy approximately 5% of the area of its shape in a hatched, mesh, or other suitable pattern.", "Herein, reference to FLM encompasses such material, where appropriate.", "Although this disclosure describes or illustrates particular electrodes made of particular conductive material forming particular shapes with particular Bills having particular patterns, this disclosure.", "contemplates any suitable electrodes made of any suitable conductive material forming any suitable shapes with any suitable fill percentages having any suitable patterns.", "Where appropriate, the shapes of the electrodes (or other elements) of a touch sensor may constitute in whole or in part one or more macro-features of the touch sensor.", "One or more characteristics of the implementation of those shapes (such as, for example, the conductive materials, fills, or patterns within the shapes) may constitute in whole or in part one or more micro-features of the touch sensor.", "One or more macro-features of a touch sensor may determine one or more characteristics of its functionality, and one or more micro-features of the touch sensor may determine one or more optical features of the touch sensor, such as transmittance, refraction, or reflection.", "A mechanical stack may contain the substrate (or multiple substrates) and the conductive material forming the drive or sense electrodes of touch sensor 10.In certain embodiments, the conductive material used for the drive or sense electrodes may also be used for a portion of the display screen (e.g., the same conductive material may be used for the sense electrodes of a touch sensor and for the reference voltage layer of a display screen).", "In some embodiments, the mechanical stack may be within or comprise a portion of a display stack configured to generate images.", "As an example and not by way of limitation, the mechanical stack may include a first layer of optically clear adhesive (OCA) beneath a cover panel of a display stack.", "The cover panel may be clear and made of a resilient material suitable for repeated touching, such as for example glass, polycarbonate, or poly(methyl methacrylate) (PMMA).", "This disclosure contemplates any suitable cover panel made of any suitable material.", "The first layer of OCA may be disposed between a layer or substrate of the display stack and the substrate with the conductive material forming the drive or sense electrodes.", "The substrate with the conductive material may provide a benefit or feature in producing an image (e.g., it may be a layer or substrate found in a typical, non-touch, display stack) or it may be a layer added specifically to provide a substrate on which the electrodes are formed.", "In some embodiments, the mechanical stack may also include a second layer of OCA.", "In some embodiments, the mechanical stack may also include a dielectric layer (which may be made of polyethylene terephthalate (PET) or another suitable material, similar to the substrate with the conductive material forming the drive or sense electrodes).", "As an alternative, where appropriate, a thin coating of a dielectric material may be applied instead of the second layer of OCA and/or the dielectric layer.", "The second layer of OCA may be disposed between the substrate with the conductive material making up the drive or sense electrodes and the dielectric layer, and the dielectric layer may be disposed between the second layer of OCA and another layer of the display stack.", "As an example only and not by way of limitation, the cover panel may have a thickness of approximately 1 mm; the first layer of OCA may have a thickness of approximately 0.05 mm; the substrate with the conductive material forming the drive or sense electrodes may have a thickness of approximately 0.05 mm; the second layer of OCA may have a thickness of approximately 0.05 mm; and the dielectric layer may have a thickness of approximately 0.05 mm.", "Although this disclosure describes a particular mechanical stack with a particular number of particular layers made of particular materials and having particular thicknesses, this disclosure contemplates any suitable mechanical stack with any suitable number of any suitable layers made of any writable materials and having any suitable thicknesses.", "In particular embodiments, the drive or sense electrodes in touch sensor 10 may be made of ITO in whole or in part.", "In particular embodiments, the drive or sense electrodes in touch sensor 10 may be made of fine lines of metal or other conductive material.", "As an example and not by way of limitation, one or more portions of the conductive material may be copper or copper-based and have a thickness of approximately 5 μm or less and a width of approximately 10 μm or less.", "As another example, one or more portions of the conductive material may be silver or silver-based and similarly have a thickness of approximately 5 μm or less and a width of approximately 10 μm or less.", "This disclosure contemplates any suitable electrodes made of any suitable material.", "Touch sensor 10 may implement a capacitive form of touch sensing.", "In a trautual-capacitance implementation, touch sensor 10 may include an array of drive and sense electrodes forming an array of capacitive nodes.", "A drive electrode and a sense electrode may form a capacitive node.", "The drive and sense electrodes forming the capacitive node may come near each other, but not make electrical contact with each other.", "Instead, the drive and sense electrodes may be capacitively coupled to each other across a space between them.", "A pulsed or alternating voltage applied to the drive electrode (by touch-sensor controller 12) may induce a charge on the sense electrode, and the amount of charge induced may be susceptible to external influence (such as a touch or the proximity of an object).", "When an object touches or comes within proximity of the capacitive node, a change in capacitance may occur at the capacitive node and touch-sensor controller 12 may measure the change in capacitance.", "By measuring changes in capacitance throughout the array, touch-sensor controller 12 may determine the position of the touch or proximity within the touch-sensitive area(s) of touch sensor 10.In a self-capacitance implementation, touch sensor 10 may include an array of electrodes of a single type that may each form a capacitive node.", "When an object touches or comes within proximity of the capacitive node, a change in self-capacitance may occur at the capacitive node and touch-sensor controller 12 may measure the change in capacitance, for example, as a change in the amount of charge needed to raise the voltage at the capacitive node by a pre-determined amount.", "As with a inutual-capacitance implementation, by measuring changes in capacitance throughout the array, touch -sensor controller 12 may determine the position of the touch or proximity within the touch-sensitive area(s) of touch sensor 10.This disclosure contemplates any suitable form of capacitive touch sensing, where appropriate.", "In particular embodiments, one or more drive electrodes may together form a drive line running horizontally or vertically or in any suitable orientation.", "Similarly, one or more sense electrodes may together form a sense line running horizontally or vertically or in any suitable orientation.", "In particular embodiments, drive lines may run substantially perpendicular to sense lines.", "Herein, reference to a drive line may encompass one or more drive electrodes making up the drive line, and vice versa, where appropriate.", "Similarly, reference to a sense line may encompass one or more sense electrodes making up the sense line, and vice versa, where appropriate.", "Touch sensor 10 may have drive and sense electrodes disposed in a pattern on one side of a single substrate.", "In such a configuration, a pair of drive and sense electrodes capacitively coupled to each other across a space between them may form a capacitive node.", "For a self capacitance implementation, electrodes of only a single type may be disposed in a pattern on a single substrate, in addition or as an alternative to having drive and sense electrodes disposed in a pattern on one side of a single substrate, touch sensor 10 may have drive electrodes disposed in a pattern on one side of a substrate and sense electrodes disposed in a pattern on another side of the substrate.", "Moreover, touch sensor 10 may have drive electrodes disposed in a pattern on one side of one substrate and sense electrodes disposed in a pattern on one side of another substrate.", "In such configurations, an intersection of a drive electrode and a sense electrode may form a capacitive node.", "Such an intersection may be a location where the drive electrode and the sense electrode “cross” or come nearest each other in their respective planes.", "The drive and sense electrodes do not make electrical contact with each other—instead they are capacitively coupled to each other across a dielectric at the intersection.", "Although this disclosure describes particular configurations of particular electrodes forming particular nodes, this disclosure contemplates any suitable configuration of any suitable electrodes forming any suitable nodes.", "Moreover, this disclosure contemplates any suitable electrodes disposed on any suitable number of any suitable substrates in any suitable patterns.", "As described above, a change in capacitance at a capacitive node of touch sensor 10 may indicate a touch or proximity input at the position of the capacitive node.", "Touch-sensor controller 12 may detect and process the change in capacitance to determine the presence and location of the touch or proximity input.", "Touch-sensor controller 12 may then communicate information about the touch or proximity input to one or more other components (such one or more central processing units (CPUs)) of a device that includes touch sensor 10 and touch-sensor controller 12, which may respond to the touch or proximity input by initiating a function of the device (or an application running on the device) associated with it.", "Although this disclosure describes a particular touch-sensor controller having particular functionality with respect to a particular device and a particular touch sensor, this disclosure contemplates any suitable touch-sensor controller having any suitable functionality with respect to any suitable device and any suitable touch sensor.", "Touch-sensor controller 12 may be one or more integrated circuits (ICs), such as for example general-purpose microprocessors, microcontrollers, programmable logic devices or arrays, or application-specific ICs (ASICs).", "In particular embodiments, touch-sensor controller 12 comprises analog circuitry, digital logic, and digital non-volatile memory.", "In particular embodiments, touch-sensor controller 12 is disposed on a flexible printed circuit (FPC) bonded to the substrate of touch sensor 10.The FPC may be active or passive, where appropriate.", "In particular embodiments, multiple touch-sensor controllers 12 are disposed on the FPC.", "Touch-sensor controller 12 may include a processor unit, a drive unit, a sense unit, a display unit, and a storage unit.", "The drive unit may supply drive signals to the drive electrodes of touch sensor 10.The sense unit may sense charge at the capacitive nodes of touch sensor 10 and provide measurement signals to the processor unit representing capacitances at the capacitive nodes, The processor unit may control the supply of drive signals to the drive electrodes by the drive unit and process measurement signals from the sense unit to detect and process the presence and location of a touch or proximity input within the touch-sensitive area(s) of touch sensor 10.The processor unit may also track changes in the position of a touch or proximity input within the touch-sensitive area(s) of touch sensor 10.The storage unit may store programming for execution by the processor unit, including programming for controlling the drive unit to supply drive signals to the drive electrodes, programming for processing measurement signals from the sense unit, and other suitable programming, where appropriate.", "Although this disclosure describes a particular touch-sensor controller having a particular implementation with particular components, this disclosure contemplates any suitable touch-sensor controller having any suitable implementation with any suitable components.", "Tracks 14 of conductive material disposed on the substrate of touch sensor 10 may couple the drive or sense electrodes of touch sensor 10 to connection pads 16, also disposed on the substrate of touch sensor 10.As described below, connection pads 16 facilitate coupling of tracks 14 to touch-sensor controller 12.Tracks 14 may extend into or around (e.g.", "at the edges of) the touch-sensitive area(s) of touch sensor 10.Particular tracks 14 may provide drive connections for coupling touch-sensor controller 12 to drive electrodes of touch sensor 10, through which the drive unit of touch-sensor controller 12 may supply drive signals to the drive electrodes.", "Other tracks 14 may provide sense connections for coupling touch-sensor controller 12 to sense electrodes of touch sensor 10, through which the sense unit of touch-sensor controller 12 may sense charge at the capacitive nodes of touch sensor 10.Tracks 14 may be made of fine lines of metal or other conductive material.", "As an example and not by way of limitation, the conductive material of tracks 14 may be copper or copper-based and have a width of approximately 100 μm or less.", "As another example, the conductive material of tracks 14 may be silver or silver-based and have a width of approximately 100 μm or less.", "In particular embodiments, tracks 14 may be made of ITO in whole or in part in addition or as an alternative to fine lines of metal or other conductive material.", "Although this disclosure describes particular tracks made of particular materials with particular widths, this disclosure contemplates any suitable tracks made of any suitable materials with any suitable widths.", "In addition to tracks 14, touch sensor 10 may include one or more ground lines terminating at a ground connector (which may be a connection pad 16) at an edge of the substrate of touch sensor 10 (similar to tracks 14).", "Connection pads 16 may be located along one or more edges of the substrate, outside the touch-sensitive area(s) of touch sensor 10.As described above, touch-sensor controller 12 may be on an FPC.", "Connection pads 16 may be made of the same material as tracks 14 and may be bonded to the FPC using an anisotropic conductive film (ACF).", "Connection 18 may include conductive lines on the FPC coupling touch-sensor controller 12 to connection pads 16, in turn coupling touch-sensor controller 12 to tracks 14 and to the drive or sense electrodes of touch sensor 10.This disclosure contemplates any suitable connection 18 between touch-sensor controller 12 and touch sensor 10.FIG.", "2 illustrates a profile view of a portion of an example touch screen in which a pixel layer provides a pixel-drive signal to a display layer of a LCD, and a reference voltage layer provides the display layer of the LCD with a reference voltage and provides an integrated touch sensor with a drive signal.", "Touch screen 200 includes a stack of layers that provide both an image, via a display portion, and touch sensing, via an integrated touch sensor.", "The display portion of touch screen 200 is configured to provide images through a two-dimensional array of pixels.", "The touch sensor is configured to determine a relative location of a touch input within touch screen 200.The depicted layers of touch screen 200 are display layer(s) 210, reference voltage layer 220, sensor substrate 230, sense electrodes 240, and pixel layer 250.Additional layers of touch screen 200 are not depicted.", "For example, touch screen 300 may include one or more layers, materials, and/or components above sense electrodes 240, below pixel layer 250, and/or in-between any of the other depicted layers of touch screen 200.Display layer(s) 210 may include pixels which provide images for touch screen 200.Display layer(s) 210 may include any suitable number of layers of touch screen 200.For example, display layer(s) 210 may include a single display layer or more than one display layer.", "In some embodiments, display layer(s) 210 may be a liquid crystal layer that adjusts a polarization of light passing through the layer.", "In some embodiments, display layer(s) 210 may be the liquid crystal layer and any combination of one or more glass substrate layers with electrodes and or one or more polarizing filter layers.", "In some embodiments, display layer(s) 210 may include VCOM layer(s) and/or pixel layer(s).", "The color of the pixels of display layer(s) 210 may be determined, in part, based on an electrical potential between a pixel layer 250 and reference voltage layer 220 The reference voltage may be referred to as a common voltage or VCOM.", "In addition to providing a reference voltage for display layer(s) 210, reference voltage layer 220 may also provide the drive signal for a touch sensor.", "For example, in the embodiment depicted in FIG.", "2, the touch sensor portion of touch screen 200 may include sense electrodes 240, sensor substrate 230, and reference voltage layer 220.In such an embodiment, reference voltage layer 220 may act as the drive electrodes of a touch sensor.", "This may allow the same layer, reference voltage layer 220, to provide both a reference voltage for display layer(s) 210 and a drive signal for a touch sensor.", "Reference voltage layer 220 may he electrically conductive so as to provide both the reference voltage and the drive signal.", "In certain embodiments, the reference voltage layer 220 may comprise ITO.", "In some embodiments, reference voltage layer 220 may include fine lines of metal.", "The fine lines of metal may be used to provide both the reference voltage for display layer(s) 210 as well as the drive signals for the touch sensor.", "In some embodiments, the fine lines of metal may be arranged in a mesh configuration.", "In some embodiments, the fine lines of metal, may be electrically isolated drive lines that are all pulsed simultaneously to provide the reference voltage for display layer(s) 210.In some embodiments, the fine lines of metal may be electrically isolated drive lines that are each pulsed one at a time to provide drive signals to sense electrodes 240.In some embodiments, instead of pulsing each of the electrically isolated drive lines one at a time to provide drive signals to sense electrodes 240, two or more of the electrically isolated drive lines (such as, for example, two of the electrically isolated drive lines, three of the electrically isolated drive lines, or any other number of the electrically isolated drive lines) may be pulsed simultaneously to provide drive signals to sense electrodes 240.In the depicted embodiment, sensor substrate 230 is located between sense electrodes 240 and reference voltage layer 220.In some embodiments, sensor substrate 230 may comprise an additional layer that would not be fund in a traditional non-touch sensitive LCD display stack.", "In some such embodiments, sensor substrate 230 may comprise non-birefringent material.", "The use of a non-birefringent material may avoid undesirable twisting of the light passing through the material.", "In some embodiments, sensor substrate 230 may comprise an existing layer that would be found in a traditional non-touch sensitive LCD display stack.", "For example, sensor substrate 230 may be a color filter layer of an LCD display stack.", "In some embodiments, sensor substrate 230 may comprise multiple layers, Pixel layer 250 may be configured to change the characteristics of the crystals within display layer(s) 210 (e.g., to change the image to be displayed by touch screen 200), In particular embodiments, pixel layer 250 may comprise a two-dimensional array of pixel electrodes.", "The size of the two-dimensional array of pixel electrodes may correspond to the number of display pixels of touch screen 200 (e.g., each pixel to be displayed may have its own respective pixel electrode(s)).", "In some embodiments, each pixel electrode may he individually controlled to generate an image.", "Although the depicted embodiment includes an LCD display stack, other embodiments may comprise other types of display stacks (e.g., any display stack that includes a reference voltage layer).", "For example, in some embodiments, an organic light emitting diode (OLED) display stack may be used for touch screen 200.FIG.", "3 illustrates a profile view of a portion of an example touch screen in which a pixel-drive layer provides a pixel-drive signal to a display layer of a LCD and a drive signal to an integrated touch sensor, and a reference voltage layer provides a reference voltage for the display layer of the LCD and provides a sense signal to a touch screen controller.", "Similar to touch screen 200, touch screen 300 provides both an image and touch sensitivity.", "In FIG.", "3, touch screen 300 may include several layers.", "The depicted layers of touch screen 300 include voltage layer 340, display layer(s) 310, and pixel-drive layer 330.Additional layers of touch screen 300 are not depicted.", "For example, touch screen 300 may include one or more layers, materials, and/or components above voltage layer 340, below pixel-drive layer 330, and/or in-between any of the other depicted layers of touch screen 300.In the embodiment depicted in FIG.", "3, the drive and sense electrodes of a touch sensor are implemented through pixel-drive layer 330 and reference voltage layer 340, respectively.", "These layers also provide their traditional functionality for display layer(s) 310.For example, pixel-drive layer 330 may be configured to change the characteristics of the crystals within display layer(s) 310 (e.g., to change the image to be displayed by touch screen 300) and may be configured to provide a drive signal for a touch sensor; and reference voltage layer 340 may be configured to provide a reference voltage for display layer(s) 310 and may be configured to provide sense signals to a touch screen controller (i.e., where the sense signals are provided by the reference voltage layer 340 as a result of the drive signals provided to the reference voltage layer 340 by pixel-drive layer 330).", "In addition, in the depicted embodiment, display layer(s) 310 may also act as the sensor substrate for the touch sensor.", "In particular embodiments, pixel-drive layer 330 may comprise a two-dimensional array of pixel-drive electrodes, The size of the two-dimensional array of pixel-drive electrodes may correspond to the number of display pixels of touch screen 300 (e.g., each pixel to be displayed may have its own respective pixel-drive electrode).", "While the pixel-drive electrodes may be individually controlled to generate an image, in some embodiments they may be grouped together to provide drive signals for the touch sensor.", "For example, one or more rows of pixel-drive electrodes may be used collectively as a single drive electrode (e.g., the same drive signal may be sent to all the pixel-drive electrodes within one or more rows pixel drive electrodes).", "In some embodiments, one or both of pixel-drive layer 330 and reference voltage layer 340 may comprise fine lines of metal, in particular embodiments, the fine lines of metal for pixel-drive layer 330 and/or reference voltage layer 340 may be arranged in a mesh fashion.", "In some embodiments, fine lines of metal may be connected between the pixel-drive electrodes and a touch screen controller.", "Although the depicted embodiment includes an LCD display stack, other embodiments may comprise other types of display stacks (e.g., any display stack that includes a reference voltage layer).", "For example, in some embodiments, an organic light emitting diode (OLED) display stack may be used for touch screen 300.FIG.", "4 illustrates an overhead view of an example touch screen in which pixel-drive electrodes provide a display portion of a touch screen with a pixel-drive signal and provide an integrated touch sensor of the touch screen with a drive signal.", "In the depicted embodiment, touch screen 400 comprises a four-by-four display with an integrated two-by-two touch sensor, The four-by-four display comprises the individual pixels of display layer(s) (not depicted).", "Each pixel of the display has its own associated pixel-drive electrode 430.These pixel-drive electrodes 430 are grouped into subsets of pixel-drive electrodes 430 to form drive electrodes 480.The two-by-two touch sensor comprises sense electrodes 440 and the two subsets of pixel-drive electrodes 430 that form drive electrodes 480.In order to form drive electrodes 480, pixel-drive electrodes 430 are arranged into two subsets (drive electrode 480a and drive electrode 480b), each subset comprises a two-by-four array of pixel-drive electrodes 430.Controller 450 is separately connected to each pixel-drive electrode 430 and thus may treat pixel-drive electrodes 430 as separate entities when generating an image and collectively (as subsets) when generating a drive signal to determine a location of a touch input.", "In this embodiment, the sensor substrate (not shown), is located between sense electrodes 440 and drive electrodes 480.In the depicted embodiment, touch screen controller 450 is connected to sense electrodes 440 as well as the individual pixel drive electrodes 430 that form drive electrodes 480.This may allow touch screen controller 450 to both adjust the pixel-drive signal to control the image generated by touch screen 400 and to manage the drive signal for the touch sensor used to determine the relative location of a touch input.", "Because pixel-drive electrodes 430 are used for both the touch sensor functionality and for creating the displayed image, touch screen controller 450 may need to synchronize how and when it sends pixel-drive signals and drive signals.", "While the pixel-drive electrodes have been grouped together in rows in the depicted embodiment, some embodiments may group the pixel-drive electrodes into clusters (e.g., two-by-two clusters) or may not group them together at all.", "For example, sense electrodes 440 may separately detect a touch input based on a change in the charge, capacitance, or electrical potential from each of the individual pixel-drive electrodes.", "FIG.", "5 illustrates an overhead view of an example touch screen in which a reference voltage layer provides a display portion of a touch screen with a reference voltage and provides an integrated touch sensor of the touch screen with a drive signal.", "In FIG.", "5, touch screen 500 includes touch screen controller 550 coupled to drive electrodes 530 and sense electrodes 540.Drive electrodes 530 may he spaced so as to provide a reference voltage for a display layer(s) (not depicted).", "Drive electrodes 530 may also be configured to provide drive signals to a touch sensor, In some embodiments, drive electrodes 530 may be oriented perpendicularly to the orientation of sense electrodes 540.In some embodiments, drive electrodes 530 may be made of fine lines of metal.", "Touch screen controller 550 may use drive electrodes 530 to provide drive signals for a touch sensor and to provide a reference voltage for a display layer(s) (e.g., display layer(s) 210 of an LCD display stack).", "As discussed above with respect to FIG.", "4, touch screen controller 550 may synchronize the reference voltage and the drive signals being sent over drive electrodes 530.Touch screen controller 550 may then use the sense signal provided by sense electrodes 540 to determine a relative location of a touch input.", "Although FIGS.", "1-5 have been described above as including particular components, the systems of FIGS.", "1-5 may include any combination of any of the described components and any of the options or features described herein, as would be understood by one of ordinary skill in the art based upon the teachings of the disclosure.", "For example and not by way of limitation, any of the options or features described herein may be utilized in combination with the illustrated embodiments of FIGS.", "1-5 and/or any number of the other options or features also described herein as would be understood by one of ordinary skill in the art based upon the teachings of the disclosure.", "Herein, reference to a computer-readable non-transitory storage medium may include a semiconductor-based or other integrated circuit (IC), such as for example a field-programmable gate array (FPGA) or an application-specific IC (ASIC), a hard disk, an HUD, a hybrid hard drive (HHD), an optical disc, an optical disc drive (ODD), a magneto-optical disc, a magneto-optical drive, a floppy disk, a floppy disk drive (FDD), magnetic tape, a holographic storage medium, a solid-state drive (SSD), a RAM-drive, a SECURE DIGITAL card, a SECURE DIGITAL drive, another suitable medium, or a suitable combination of these, where appropriate, A computer-readable non-transitory storage medium may be volatile, non-volatile, or a combination of volatile and non-volatile, where appropriate.", "Herein, “or” is inclusive and not exclusive, unless expressly indicated otherwise or indicated otherwise by context.", "Therefore, herein, “A or B” means “A, B, or both,” unless expressly indicated otherwise or indicated otherwise by context.", "Moreover, “and” is both joint and several, unless expressly indicated otherwise or indicated otherwise by context.", "Therefore, herein, “A and B” means “A and B, jointly or severally,” unless expressly indicated otherwise or indicated otherwise by context.", "This disclosure encompasses all changes, substitutions, variations, alterations, and modifications to the example embodiments herein that a person haying ordinary skill in the art would comprehend.", "Moreover, reference in the appended claims to an apparatus or system or a component of an apparatus or system being adapted to, arranged to, capable of, configured to, enabled to, operable to, or operative to perform a particular function encompasses that apparatus, system, component, whether or not it or that particular function is activated, turned on, or unlocked, as long as that apparatus, system, or component is so adapted, arranged, capable, configured, enabled, operable, or operative." ] ]
Patent_15874149
[ [ "SYSTEM AND METHOD FOR ANALYSIS AND CREATION OF MUSIC", "A method and system for analyzing patterns in the relationships of notes of an input piece of music.", "The method comprises generating a set of the most frequently occurring note pitches in ascending pitch order that matches an interval pattern, and detecting out-of-key pitches that lie outside of this internal pattern.", "One or more potential key sequence bifurcations are identified which represent a list of possible key sequences according to forwards and backwards analysis.", "By finding patterns of repetition in the chordal sequences that may be generated according to these key sequence bifurcations, a key sequence that allows the most frequently recurring chord sequences may be chosen.", "Chord sequences may be analyzed by using ghost chords, temporary harmonic structures that are created, updated and finalized over time according to a combination of essential and inessential note fragments.", "The method further comprises identifying non-harmony pitches according to the analyzed chord sequence." ], [ "1.A method for electronically composing music, the method comprising: retrieving, via a processing device, music data blocks from a library of music data blocks, the music data blocks extracted from sequences of abstract music data from music input; generating, via the processing device, key and chord sequences of abstract music data by re-arranging the music data blocks into slots of a set of frames based on key and chord combination rules; selecting, via the processing device, a rhythm sequence from rhythm data extracted from the music input; selecting, via the processing device, a pitch for each note slot in the rhythm sequence based on a set of movement combination rules and the generated key and chord sequences; composing, via the processing device, music data based on the selected pitch for each note slot in the rhythm sequence; and converting, via the processing device, the music data into a music output data format file.", "2.The method of claim 1 wherein the library of music data blocks include sequences of abstract music data from of a plurality of compositional styles.", "3.The method of claim 1 wherein the key and chord combination rules comprise rules that determine whether keys and chords can be connected together.", "4.The method of claim 1 wherein the key and chord combination rules include rules for blocks of chord sequences that can be placed adjacently in a chord block frame in relationship to an underlying key sequence.", "5.The method of claim 1 wherein selecting a pitch for each not slot in the rhythm sequence further comprises: determining, via the processing device, a set of possible pitches for each note slot in the rhythm sequence by populating note slots in the rhythm sequence with the set of possible pitches; and reducing, via the processing device, the set of possible pitches for each note based on the key and chord sequences.", "6.The method of claim 5 further comprising randomly selecting a pitch from the set of possible pitches.", "7.The method of claim 5 further comprising limiting the set of possible pitches to match a limited scale of pitches from the music input.", "8.The method of claim 1 wherein the rhythm sequence is generated from analysis of repeating rhythms within individual musical parts of the music input.", "9.The method of claim 1 wherein the rhythm sequence is associated with a harmony sequence.", "10.The method of claim 9 wherein selecting a pitch for each note slot in the rhythm sequence further comprises: determining the pitch is a harmony note based on the harmony sequence; and selecting the pitch based on a note that corresponds to a key and chord from the key and chord sequences.", "11.The method of claim 9 wherein selecting a pitch for each note slot in the rhythm sequence further comprises: determining the pitch is a non-harmony note based on the harmony sequence; and selecting the pitch based on previous scale number in line, current scale number in line, a next scale number in line, previous chord, current chord, next chord, previous key, current key, next key, and a set of other sounding scalic numbers.", "12.The method of claim 1 wherein the movement combinations rules include rules for full scalic bound movement combination, full semitonal movement combination, full scalic unbound movement combination, part dependent single scalic bound movement combination, part dependent single semitonal movement combination, part dependent single scalic unbound movement combination, single scalic bound movement combination, single semitonal movement combination, and single scalic unbound movement combination.", "13.A system for electronically composing music, the system comprising: a processor; and a memory having executable instructions stored thereon that when executed by the processor cause the processor to: retrieve music data blocks from a library of music data blocks, the music data blocks extracted from sequences of abstract music data from music input; generate key and chord sequences of abstract music data by re-arranging the music data blocks into slots of a set of frames based on key and chord combination rules; select a rhythm sequence from rhythm data extracted from the music input; select a pitch for each note slot in the rhythm sequence based on a set of movement combination rules and the generated key and chord sequences; compose music data based on the selected pitch for each note slot in the rhythm sequence; and convert the music data into a music output data format file.", "14.The system of claim 13 wherein the library of music data blocks include sequences of abstract music data from of a plurality of compositional styles.", "15.The system of claim 13 wherein the key and chord combination rules comprise rules that determine whether keys and chords can be connected together.", "16.The system of claim 13 wherein the processor is further configured to: determine a set of possible pitches for each note slot in the rhythm sequence by populating note slots in the rhythm sequence with the set of possible pitches; and reduce the set of possible pitches for each note based on the key and chord sequences.", "17.Non-transitory computer readable media comprising program code that when executed by a programmable processor causes execution of a method for electronically composing music, the computer readable media comprising: computer program code for retrieving music data blocks from a library of music data blocks, the music data blocks extracted from sequences of abstract music data from music input; computer program code for generating key and chord sequences of abstract music data by re-arranging the music data blocks into slots of a set of frames based on key and chord combination rules; computer program code for selecting a rhythm sequence from rhythm data extracted from the music input; computer program code for selecting a pitch for each note slot in the rhythm sequence based on a set of movement combination rules and the generated key and chord sequences; computer program code for composing music data based on the selected pitch for each note slot in the rhythm sequence; and computer program code for converting the music data into a music output data format file.", "18.The non-transitory computer readable media of claim 17 wherein the library of music data blocks include sequences of abstract music data from of a plurality of compositional styles.", "19.The non-transitory computer readable media of claim 17 wherein the key and chord combination rules comprise rules that determine whether keys and chords can be connected together.", "20.The non-transitory computer readable media of claim 17 further comprising: computer program code for determining a set of possible pitches for each note slot in the rhythm sequence by populating note slots in the rhythm sequence with the set of possible pitches; and computer program code for reducing the set of possible pitches for each note based on the key and chord sequences." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Composing music is the process of putting sounds together in an organized structure.", "Music composition is regarded by some as an elitist, almost mysterious ability that requires years of training.", "Both professional and amateur musicians are often interested in expanding and/or improving their respective capabilities in music composition to thereby produce a unique sound, a unique presentation, and/or a unique instrumentation.", "The accomplishment of this has generally been limited either to a traditional approach employing a musical instrument itself or to utilization of a significantly restricted music-analysis device.", "Prior art devices do not provide a production of music in accord with the high standards and flexibility sought by musicians.", "Existing solutions have remained inadequate, particularly for users who are seeking to produce music in a variety of styles and with a high standard of quality.", "These solutions typically are either too simple or crude to be useful, or do not offer the user adequate input as to how the music should be composed, both generally, and with regard to how the music may vary within a composition.", "Additionally, these solutions are one-dimensional, typically taking musical elements and merely connecting them along a timeline.", "In that sense, there is both a lack of flexibility as to the potential variation within the composed music, as well as a lack of depth in the finished product.", "There is thus a need automatically compose music that accommodates the creation of musical compositions in any style of music." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention provides a method and system or analyzing patterns in the relationships of notes of an input piece of music.", "The method comprises generating a set of the most frequently occurring note pitches in ascending pitch order that matches an interval pattern, and detecting out-of-key pitches that lie outside of this interval pattern.", "One or more potential key sequence bifurcations are identified which represent a list of possible key sequences according to forwards and backwards analysis.", "By finding patterns of repetition in the chordal sequences that may be generated according to these key sequence bifurcations, a key sequence that allows the most frequently recurring chord sequences may be chosen.", "Chord sequences may be analyzed by using ghost chords, temporary harmonic structures that are created, updated and finalized over time according to a combination of essential and inessential note fragments.", "The method further comprises identifying non-harmony pitches according to the analyzed chord sequence.", "The interval pattern represents a scale.", "Detecting one or more out of key pitches may result modulation to flatter or sharper keys.", "In certain embodiments, a flat modulation weight, a sharp modulation weight, a highest change flat, and a highest change sharp for the one or more out of key pitches are determined.", "For a set of out-of-key pitches, the flat modulation weight is the sum of the least number of keys moved in a flat direction from an original key until each new pitch is found for all pitches in the set, the sharp modulation weight is the sum of the least number of keys moved in a sharp direction from an original key until each new pitch is found for all pitches in the set, the highest change flat is the highest of these key movements in the flat direction, and the highest change sharp is the highest of these key movements in the sharp direction.", "The method may further include performing a flat modulation for one or more out of key pitches if the flat modulation weight is less than the sharp modulation weight, wherein the amount of keys to move is equal to the highest change flat when modulating in the flat direction, performing a sharp modulation for one or more out of key pitches if the sharp modulation weight is less than the flat modulation weight, wherein the amount of keys to move is equal to highest change sharp when modulating in the sharp direction, and wherein if the flat modulation weight equals the sharp modulation weight, no modulation is performed.", "A fragment may be a portion of a note that is chosen to be as long as it can be whilst being bounded by harmonic change.", "An essential fragment may be a fragment whose pitch value contributes to chordal analysis via ghost chords and an inessential fragment may be a fragment whose pitch is ignored in chordal analysis.", "An inessential fragment must be bound adjacently to an essential fragment within its line with a pitch difference between the two fragments less than or equal to 2 semitones.", "In some embodiments, ghost chords may be bounded by an arbitrarily chosen analysis interval which may be, for example, a scalic 5th.", "Updating a ghost chord may include adding one or more note pitches to the ghost chord provided that there exists a resultant inversion of pitches within the ghost chord that can lie within the related analysis interval.", "Determining the desired chord sequence may further include employing a fitness function for valuation of various combinations of essential and inessential fragment combinations.", "The fitness function may include at least one or a combination of the following goals: determining a chord sequence that has the lowest triadic chordal numbers possible, determining a chord sequence in which the most note pitches lie, and determining a chord sequence that provides a most tempered harmonic rhythm.", "Identifying one or more non-harmony pitches may further include recording a previous scale number in a given line, a current scale number the given line, a next scale number in the given line, a previous chord, a current chord, a next chord, a previous key, a current key, a next key, and a set of other sounding scalic numbers.", "The system comprises a processor, and a memory having executable instructions stored thereon that when executed by the processor cause the processor to generate a set of most frequently occurring note pitches in ascending pitch order that matches an interval pattern and detect pitches that lie outside of this interval pattern.", "The processor is further configured to identify a plurality of bifurcations from the list of possible key sequences, generate their resultant as well as subsequent chord sequences by detecting essential and inessential note fragments, assign fitness scores to sequences of abstract data according to arbitrary fitness functions and identify non-harmony pitches according to the finalized chord sequence." ], [ "COPYRIGHT NOTICE A portion of the disclosure of this patent document contains material, which is subject to copyright protection.", "The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent files or records, but otherwise reserves all copyright rights whatsoever.", "FIELD OF THE INVENTION The invention described herein generally relates to analysis of music inputs and music creation based on the analysis.", "BACKGROUND OF THE INVENTION Composing music is the process of putting sounds together in an organized structure.", "Music composition is regarded by some as an elitist, almost mysterious ability that requires years of training.", "Both professional and amateur musicians are often interested in expanding and/or improving their respective capabilities in music composition to thereby produce a unique sound, a unique presentation, and/or a unique instrumentation.", "The accomplishment of this has generally been limited either to a traditional approach employing a musical instrument itself or to utilization of a significantly restricted music-analysis device.", "Prior art devices do not provide a production of music in accord with the high standards and flexibility sought by musicians.", "Existing solutions have remained inadequate, particularly for users who are seeking to produce music in a variety of styles and with a high standard of quality.", "These solutions typically are either too simple or crude to be useful, or do not offer the user adequate input as to how the music should be composed, both generally, and with regard to how the music may vary within a composition.", "Additionally, these solutions are one-dimensional, typically taking musical elements and merely connecting them along a timeline.", "In that sense, there is both a lack of flexibility as to the potential variation within the composed music, as well as a lack of depth in the finished product.", "There is thus a need automatically compose music that accommodates the creation of musical compositions in any style of music.", "SUMMARY OF THE INVENTION The present invention provides a method and system or analyzing patterns in the relationships of notes of an input piece of music.", "The method comprises generating a set of the most frequently occurring note pitches in ascending pitch order that matches an interval pattern, and detecting out-of-key pitches that lie outside of this interval pattern.", "One or more potential key sequence bifurcations are identified which represent a list of possible key sequences according to forwards and backwards analysis.", "By finding patterns of repetition in the chordal sequences that may be generated according to these key sequence bifurcations, a key sequence that allows the most frequently recurring chord sequences may be chosen.", "Chord sequences may be analyzed by using ghost chords, temporary harmonic structures that are created, updated and finalized over time according to a combination of essential and inessential note fragments.", "The method further comprises identifying non-harmony pitches according to the analyzed chord sequence.", "The interval pattern represents a scale.", "Detecting one or more out of key pitches may result modulation to flatter or sharper keys.", "In certain embodiments, a flat modulation weight, a sharp modulation weight, a highest change flat, and a highest change sharp for the one or more out of key pitches are determined.", "For a set of out-of-key pitches, the flat modulation weight is the sum of the least number of keys moved in a flat direction from an original key until each new pitch is found for all pitches in the set, the sharp modulation weight is the sum of the least number of keys moved in a sharp direction from an original key until each new pitch is found for all pitches in the set, the highest change flat is the highest of these key movements in the flat direction, and the highest change sharp is the highest of these key movements in the sharp direction.", "The method may further include performing a flat modulation for one or more out of key pitches if the flat modulation weight is less than the sharp modulation weight, wherein the amount of keys to move is equal to the highest change flat when modulating in the flat direction, performing a sharp modulation for one or more out of key pitches if the sharp modulation weight is less than the flat modulation weight, wherein the amount of keys to move is equal to highest change sharp when modulating in the sharp direction, and wherein if the flat modulation weight equals the sharp modulation weight, no modulation is performed.", "A fragment may be a portion of a note that is chosen to be as long as it can be whilst being bounded by harmonic change.", "An essential fragment may be a fragment whose pitch value contributes to chordal analysis via ghost chords and an inessential fragment may be a fragment whose pitch is ignored in chordal analysis.", "An inessential fragment must be bound adjacently to an essential fragment within its line with a pitch difference between the two fragments less than or equal to 2 semitones.", "In some embodiments, ghost chords may be bounded by an arbitrarily chosen analysis interval which may be, for example, a scalic 5th.", "Updating a ghost chord may include adding one or more note pitches to the ghost chord provided that there exists a resultant inversion of pitches within the ghost chord that can lie within the related analysis interval.", "Determining the desired chord sequence may further include employing a fitness function for valuation of various combinations of essential and inessential fragment combinations.", "The fitness function may include at least one or a combination of the following goals: determining a chord sequence that has the lowest triadic chordal numbers possible, determining a chord sequence in which the most note pitches lie, and determining a chord sequence that provides a most tempered harmonic rhythm.", "Identifying one or more non-harmony pitches may further include recording a previous scale number in a given line, a current scale number the given line, a next scale number in the given line, a previous chord, a current chord, a next chord, a previous key, a current key, a next key, and a set of other sounding scalic numbers.", "The system comprises a processor, and a memory having executable instructions stored thereon that when executed by the processor cause the processor to generate a set of most frequently occurring note pitches in ascending pitch order that matches an interval pattern and detect pitches that lie outside of this interval pattern.", "The processor is further configured to identify a plurality of bifurcations from the list of possible key sequences, generate their resultant as well as subsequent chord sequences by detecting essential and inessential note fragments, assign fitness scores to sequences of abstract data according to arbitrary fitness functions and identify non-harmony pitches according to the finalized chord sequence.", "BRIEF DESCRIPTION OF THE DRAWINGS The invention is illustrated in the figures of the accompanying drawings which are meant to be exemplary and not limiting, in which like references are intended to refer to like or corresponding parts, and in which: FIG.", "1 illustrates a computing system according to an embodiment of the present invention; FIG.", "2 illustrates a flowchart of a method for analysis and creation of music according to an embodiment of the present invention; FIG.", "3 illustrates a diagrammatical representation of a piece of music according to an embodiment of the present invention; FIG.", "4 illustrates a hierarchy of vertical components of music according to an embodiment of the present invention; FIG.", "5 illustrates a diagram for key modulation according to an embodiment of the present invention; FIG.", "6 illustrates an exemplary modulation table of semitones according to an embodiment of the present invention; FIG.", "7A and FIG.", "7B illustrate exemplary musical pieces used for performing chordal analysis according to an embodiment of the present invention; FIG.", "8 illustrates a musical example referred to in a discussion of movement patterns according to an embodiment of the present invention; FIG.", "9 illustrates a musical example referred to in a discussion of analyzing full movement combinations according to an embodiment of the present invention; FIG.", "10 illustrates a musical example referred to in a discussion of analyzing single movement combinations according to an embodiment of the present invention; FIG.", "11 and FIG.", "12 illustrate key and chord sequences according to an embodiment of the present invention; FIG.", "13 illustrates a representation of a key sequence and chord frame according to an embodiment of the present invention; FIG.", "14 through FIG.", "18 illustrate diagrammatical representations of a part dependent frames for generating a movement pattern sequence according to an embodiment of the present invention; FIG.", "19 illustrates a pitch-empty rhythm structure of a new music piece according to an embodiment of the present invention; FIG.", "20 illustrates a rhythm structure storing a list of possible pitches according to an embodiment of the present invention; FIG.", "21 through FIG.", "26 illustrate chord and harmony reduction of possible pitches within a rhythm structure according to an embodiment of the present invention, FIG.", "27 and FIG.", "28 illustrate movement pattern reduction of possible pitches within a rhythm structure according to an embodiment of the present invention; FIG.", "29 illustrates a diagram of using movement combination information to select pitches from possible pitches within a rhythm structure for a full movement combination.", "FIG.", "30 illustrates a diagram of using movement combination information to select pitches from possible pitches within a rhythm structure for a series of single movement combinations.", "DETAILED DESCRIPTION OF THE INVENTION Subject matter will now be described snore fully hereinafter reference to the accompanying drawings, which form a part hereof, and which show, by way of illustration, exemplary embodiments in which the invention may be practiced.", "Subject matter may, however, be embodied in a variety of different forms and, therefore, covered or claimed subject matter is intended to be construed as not being limited to any example embodiments set forth herein; example embodiments are provided merely to be illustrative.", "It is to be understood that other embodiments may be utilized and structural changes may be made without departing from he scope of the present invention.", "Likewise, a reasonably broad scope for claimed or covered subject matter is intended.", "Among other things, for example, subject matter may be embodied as methods, devices, components, or systems.", "Accordingly, embodiments may, for example, take the form of hardware, software, firmware or any combination thereof (other than software per se).", "The following detailed description is, therefore, not intended to be taken in a limiting sense.", "Throughout the specification and claims, terms may have nuanced meanings suggested or implied in context beyond an explicitly stated meaning.", "Likewise, the phrase “in one embodiment” as used herein does not necessarily refer to the same embodiment and the phrase “in another embodiment” as used herein does not necessarily refer to a different embodiment.", "It is intended, for example, that claimed subject matter include combinations of example embodiments in whole or in part.", "FIG.", "1 illustrates one embodiment of a system 100 for analyzing and creating music that includes music input device 102, user interface 104, video interface 106, storage device 108, CPU 110, communications interface 112, network 114, database 116, music builder 118, and bus 128.System 100 may comprise a general purpose computing device (e.g., personal computers, mobile devices, terminals, laptops, personal digital assistants (PDA), cell phone tablet computers, or any computing device having a central processing unit and memory unit capable of connecting to a network.", "Music input device 102 may include any music equipment, computer, or any other device operable to communicate text, Musical Instrument Digital Interface (MIDI), audio, or any other representation of music to system 100 as musical input.", "The music input device 102 is communicatively coupled to user interface 104.User interface 104 may include protocols, digital interfaces and connectors to allow for communication between music input devices 102 and system 100 via bus 128.Bus 128 provides a subsystem that transfers data between the various components connected to bus 128 within system 100.Video interface 106 may also comprise a graphical user interface (GUI) or a browser application provided on a display (e.g., monitor screen, LCD or LED display, projector, etc.).", "Storage device 108 may store the musical input received from music input device 102, information elated to the musical input, analysis data from music builder 118, and one or more application programs executed by CPU 110.CPU 110 executes various processing operations such as those associated with music builder 118.Music builder 118 is configured to analyze musical input from music files on storage device 108 and composes new or original music based on the musical input.", "According to other embodiments music builder 118 may also be configured to analyze musical input received from music input device 102 as well as music files stored on a database 116.The music builder 118 includes component analysis module 120, frame analysis module 122, abstract data recreation module 124, and music generator 126.Analysis module 120 may prepare music for analysis, and perform various analyses such as vertical analysis, horizontal analysis, and other analyses, which are later described herein in greater detail.", "Frame analysis module 122 may perform additional analysis in the context of music frames and blocks (“frame analysis”).", "A frame is a term that may be used to describe the framework of repetition of a particular musical structure.", "The term “block” may be used to describe a portion of a sequence of abstract data that can be arranged in a musical structure frame.", "Some examples of abstract data used are keys, chords, rhythm, movement patterns and harmony.", "Recreation module 124 may create new sequences of abstract data from the frame analysis, which are used by music generator 126 to compose new music.", "Abstract data may refer to data representative of keys, chords, etc.", "The music builder may analyze each aspect of one or more musical input, and create frames and blocks of musical data that can be stored in database 116.Communications interface 112 may include circuitry (e.g., a network adapter) configured to allow communications and transfer of data between system 100 and database 116 via network 114.Network 114 may be any suitable type of network allowing transport of data communications across thereof.", "In one embodiment, the network may be the Internet, following known Internet protocols for data communication, or any other communication network, e.g., any local area network (LAN), or wide area network (WAN) connection.", "Database 116 may comprise a collection of data or a store of information associated with data blocks produced by music builder 118.Database 116 may also store the original input pieces as well as any new music that has been generated by music builder 118.Musical input analyzed by music builder 118 can be used to develop a musical style of composition for a given user.", "Compositional styles are able to be mixed and matched, and due to the many different aspects of musical analysis, one or more factors may be changed.", "For example, a user of the system may choose to keep some elements of a “renaissance” style but use “baroque” chord blocks or a “rock” structure with “baroque” linear movement patterns.", "Imagining two extremes of the spectrum of musical composition, at one end a random selection of notes may occur based on no experience or organized structure and at the other end, an exact repetition of a previously encountered piece may be present.", "In much the same way as a real composer would use experience of hearing many pieces to intuitively write commonly occurring aspects of music, the music builder 118 can be used to find a middle ground in this spectrum, using experience based in repetition to guide it to its final output.", "FIG.", "2 presents a flowchart of a method for analysis and creation of music according to an embodiment of the present invention.", "The method of FIG.", "2 may be executed in the system of FIG.", "1 or any other suitable processing environment.", "Music input is received, step 202.The music input may be in any format such as text, midi, or audio.", "Namely, musical notes are analyzed as opposed to sound waves.", "However, audio file formats such as MP3's may be received and parsed into notes.", "As such, the step of receiving music input may also include extracting musical notes from the music input.", "In a next step 204, the music input is prepared for analysis.", "Music input pieces (whether from text, MIDI, or audio, etc.)", "are prepared in a standardized format before performing analysis.", "The first input preparation performed may be a standardization for time.", "The MIDI approach to rhythm is a system using ticks and tempo.", "Typically a note's length may comprise many thousands of ticks, sharply contrasting with text input in which very few note lengths are greater than 10.Therefore, a standardized system of dealing with time for analysis is desirable.", "An ordered list containing the start and end times of all notes may be created.", "Let the elements of this list be numbered {x1, x2 .", ".", ".", "x(n−1), xn}.", "Then the set of lengths between these events will be {(x2x−x1), (x3−x2) .", ".", ".", "(x(n)−x(n−1)).", "The highest common factor of all lengths between events is used to divide all note lengths producing a standardized rhythmic framework for analysis.", "The second input preparation performed may be the splitting of exactly repeating segments of the input piece of music.", "Many times in music, one can observe pieces or songs with whole sections that repeat.", "This is very commonplace in pop music where a verse-chorus-verse-chorus structure pattern appears in which the verses and the choruses are exactly the same.", "The music builder may be able to identify these patterns to analyze and create single sections of music which can then be “glued” together in the correct structure of repetition when preparing for output.", "To analyze such patterns, exactly repeating subsequences of notes in the input piece are identified.", "In order to find such subsequences, the notes from the input piece of music are firstly arranged in an order such that the notes with earlier start times are listed before notes with later start times in a given sequence.", "If two notes have equal start times, notes with lower (higher by pitch) part numbers may be listed before notes with higher part numbers in the sequence.", "A list of all possible subsequences may then be derived from the ordered sequence of notes.", "For example, let a numerical representation of an ordered sequence of integers be 1, 2, 3, 4.A set of subsequences generated from this ordered sequence may be: {1} {1,2} {1,2,3} {1,2,3,4} {2} {2,3} {2,3,4} {3} {3,4} {4} From the full set of subsequences of notes, start and end times of notes suitable to be segment boundaries are determined.", "Consider the diagrammatical representation of a piece of music in FIG.", "3.It can be seen that no notes are sounding at t1 and t3.Therefore, these would be suitable times for segment boundaries.", "However, at t2, there is a sounding note held over t2, and as such, this is not a suitable segment boundary.", "Any subsequence of notes whose start or end times do not lie on suitable boundary times are removed from the list, leaving only subsequences with suitable boundary times.", "Again referring to FIG.", "3 as an example, any subsequences of notes with start or end times at t2 would be removed from the set of all subsequences.", "The remaining subsequences may then be compared for repetition.", "This involves finding a fitness measure for each repeating subsequences which may be given by a formula such as (fitness=number of repetitions of subsequence*(sum of all note lengths in subsequence)).", "This method is described in more detail in the section of this document that details blocks and frames which work in a very similar way to note subsequences and segments but concern abstract data rather than “solid” notes.", "Once the fittest subsequences of notes have been found, these form the segments of music which are passed through to the analysis module for separate analysis and recreation.", "The recreated segments will then be glued back together in the output preparation section according to the same structure by which they were input.", "The third input preparation performed may be the splitting of tracks with simultaneously sounding notes into separate lines.", "This may be performed by finding a delta calculation between the pitch movements and splitting either by finding the minimum movements per each change of notes or by a total minimum change which can be calculated recursively across the piece.", "Abstract data is extracted from the prepared music input, step 206.The abstract data may include patterns between the components of musical notes that are extracted from the music input.", "Examples include scale, keys, chords, rhythm, movement patterns and harmony.", "Extracting abstract data may include vertical and horizontal analysis of the input music.", "Vertical analysis may comprise scale, key, chord, and harmony analysis of the abstract data.", "Horizontal analysis may comprise rhythm, movement patterns, range, movement combinations, and key and chord combinations.", "These analyses are further described in the following sections below.", "Data blocks are extracted from sequences of the abstract data, step 208.A set of data blocks may be derived from the original music input piece.", "The blocks may be comprised of sections of the abstract data.", "For example, the abstract data may comprise a key sequence and the blocks derived from the key sequence may include a portion or a subsequence of the key sequence.", "The blocks generated from the abstract data may either be saved or used to create new/original music, step 210.Data blocks created from the abstract data may be saved in step 212.Blocks may be saved and stored in a database which can then be used at a future time by the music builder to create more diversity in new output pieces.", "Alternatively, in step 214, frames are extracted from the music piece.", "Blocks created from the music input may serve as building blocks for creating the frames.", "Frames may be extracted from the input piece by detecting repetitions of abstract data therein.", "In step 216, data blocks are prepared for recreation.", "Blocks of abstract data may be retrieved or selected to recreate new abstract data sequences.", "New sequences of abstract data are created in step 218.Creating new sequences of abstract data may include generating new sequences of abstract data such as key sequences and chord sequences from “old” abstract data blocks (e.g., subsequences of key and chord sequences extracted from music input or from a storage medium such as a database).", "Blocks of abstract data can be joined in frames according to one or more rules based on previous analyses, for example, key and chord combination rules created from horizontal analysis to create the ne sequences of abstract data.", "From the new abstract data, new music piece(s) are generated, step 220.Generating new music may include determining possible pitches for notes comprising the new music piece(s).", "The new music may be composed by selecting pitches for the notes of the new music piece(s) based on reduction methods and movement combination rules (which are described in further detail in the sections below).", "In a next step 222, the new music is prepared for output.", "This process may involve line splicing (reversing the line splitting performed in the music input preparation described in step 204), segment splicing (reversing the segmentation of the music input), reversal of the time refactoring of the music input, and converting from internal data format to desired output data format (e.g., a MIDI file).", "When the new music has completed preparation, the new music piece is output, step 224.Vertical Analysis Including Scales, Keys and Chords/Harmony Vertical analysis (pertaining to multiple lines) refers to the analysis of music harmonically.", "The various stages of vertical analysis according to one embodiment rely on a system of hierarchy as shown in FIG.", "4.Scale 402 is used as a basis of the vertical analysis.", "According to traditional music theory, the scale represents a set of musical pitches that dictate the base of a musical piece.", "For example, “Symphony in G major.” The concept of key 404 represents modulations that occur within a piece in relation to its underlying scale, for example, “C Major Section of Symphony in G Major.” Chord 406 represents a framework for pitches that can sound simultaneously and harmonically together within a given key, for example, “Chord F Major in C Major Section of Symphony in G Major.” Harmony 408 determines if currently sounding note pitches lie within the current chord or not, for example “Non-Harmony passing note ‘G’ over Chord F Major in C Major Section of Symphony in G Major.” It should be noted that apart from harmony (which relies on chord), all of these concepts can exist independently of each other.", "However, for the purposes of analysis it is extremely beneficial to treat them as interdependent as this provides several layers of abstraction which can be used to detect the desired patterns within the piece of input music.", "For example, knowing that a chord of G Major repeats is unlikely to help much if the contexts that it appears in are very different.", "However, if it is known that chord 5 repeats, this gives a much better indication of how the music is constructed.", "Scale Traditionally the scale that a piece is based on is either a tonal key (i.e.", "G major, E minor etc) or a mode, However, neither of these is appropriate for analysis by a computer.", "The reason is that Major and Minor scales and modes are not mutually exclusive in terms of the scales they encompass.", "For example, listed below are a Major Scale, a Minor Scale and a mode: C major—C,D,E,F,G,A,B A minor—A,B,C,D,E,F,G D dorian—D,E,F,G,A,B,C As one can see, the above actually consist of the same notes in different orders.", "Now, bearing in mind that a standardized framework for analysis is desired, it is clear that one cannot simply use these different scalic frameworks as a basis.", "For example if a chord sequence of I, IV, V was analyzed in the C Major scale as shown above, this would lead to a chord sequence of CMaj, FMaj, GMaj.", "The same numerical sequence in the dorian mode would lead to a chord sequence of DMin, GMaj, AMin.", "Not only are these different chords but they are also different types of chords.", "This approach does not work.", "If one tries just using the chords themselves (i.e.", "CMaj, FMaj, GMaj) and then analyze a chord sequence of I, IV, V from any other Major key apart from C Major, then a match would not occur.", "However, a solution may be to analyze everything according to just one mode, the major scale and then to allow the chord sequence rather than the scale basis to express the nature of the mode.", "For example, the key of A Minor would be recorded and analyzed in the key of C Major with the starting and ending chords likely to be chord 6.A goal is to find the key that has the most note pitches in the piece lying within it.", "Therefore, a group of the most frequently occurring 7 notes that lie consecutively by pitch with separation of an interval pattern based on a scale is determined.", "For example, the following interval is used: 2,2,1,2,2,2,1 (TTSTTTS=major, where “S” means a semitone and “T” means a whole ton(two semitones)).", "A method according to one embodiment for finding a scale base is described.", "All note pitches in the piece are put into a range of one octave to eliminate any octave duplication in order to count their frequency.", "The frequency of occurrence of each of these new pitches are counted and a list of them is made in descending frequency where the most commonly occurring note pitch is at the first position of the list.", "The most frequently occurring seven note pitches which can ascend by pitch with an interval pattern of (2,2,1,2,2,2,1) (Major Scale) or any of its inversions are determined.", "A list of all possible combinations of 7 note pitches (ordered by descending total frequency) in the “octave pitch” is made.", "For example, if the note pitches obtained are 1,2,3,4,5,6,7,8, the following list of 7-note pitch combinations may be generated: 1,2,3,4,5,6,7 1,2,3,4,5,6,8 1,2,3,4,5,7,8 1,2,3,4,6,7,8 etc.", "Now that a list of all groups of 7 note pitches in descending order of total frequency of occurrence have been generated, 7-note pitch combinations that fit a given interval pattern (or an inversion of it) may be determined.", "Each of the 7-note pitch combinations may be organized in ascending order of pitch.", "For each group (in ascending order) of 7 note pitches on the list, a difference is taken between consecutive notes and is used to match an interval pattern.", "This step may be repeated through a plurality of inversions of the 7 note pitches.", "The 7 note pitches are treated as a “circle” where the difference is taken between the first note and the seventh.", "As all note pitches are lying within one octave, the first note pitch is shifted up an octave to accomplish this.", "In terms of semitones, this is an addition of 12 (e.g., operations on the semitonal pitches are cyclic mod 12).", "Thus here if n1 is the first note pitch in the sequence and n7 is the seventh, results in an interval difference between the first and seventh pitches of (n1+12)−n7.As an example, let the 7 note pitches be 0,2,3,5,7,8,10.Now taking the difference between each consecutive element, (n2−1),(n3−n2) .", ".", ".", "((n1−0)+(12−n7)) is: 2,1,2,2,1,2,2.This result is used to determine a match with the interval pattern of 2,2,1,2,2,2,1.Since the difference between each consecutive element does not match the interval pattern, the process may cycle through a next inversion of the 7 note pitches by putting the lowest pitch up an octave.", "Therefore, the next inversion will be: 2,3,5,7,8,10,12.Now taking the difference between each consecutive element is: 1,2,2,1,2,2,2.The difference is again compared with 2,2,1,2,2,2,1, and is not a match.", "The next inversion produces: 3,5,7,8,10,12,14.Again, taking the difference between each consecutive element is: 2,2,1,2,2,2,1.In this iteration, the resulting difference between each consecutive element matches with the 2,2,1,2,2,2,1 interval pattern.", "Therefore the base note of the scale of 3 is determined as the scale base.", "There are situations where musical pieces may not have a full 7 pitches with the right intervals needed to create a full scale.", "For determining a scale base for in situations such as this, the pitches may be lined up against the Major Scale set above of intervals in all inversions in order to determine the scalic pitch values of these semitonal pitches and then used to calculate the highest “in-keyness” where the descending order of in-keyness by scalic pitch is the following: 1 (4 or 5) (2 or 7) (3 or 6) The inversion that has the highest “in-keyness” may be chosen as the scale base.", "The remaining scale pitches can then be calculated and filled in to complete the scale.", "For example, let {0,5,7} be the full set of semitonal pitches derived from the piece.", "Then assuming that the tonic or root note of the scale is in the first position in the framework (e.g., in any inversion, at least one of the pitches must be in the first slot), and using our “Major” set of semitonal intervals [2,2,1,2,2,2,1] as a framework, this set of semitones can be aligned in the following two ways: [0,x,x,5,7,x,x] [5,7,x,x,12(0),x,x] The slots correspond to scalic numbers.", "Now in the first array, pitches are placed in the first, fourth and fifth slots.", "In the second, pitches are placed in the first, second and fifth slots.", "Now by the hierarchy, described above, scalic pitch 4 takes precedence over scalic pitch 2.Therefore the scale base chosen is as described in the first array.", "That is to say, 0 is the scale base pitch.", "Key A traditional cycle or circle of fifths, as shown in FIG.", "5, shows a circle of modulation, for flattening and sharpening keys.", "The boxes outside the circle denote pitch.", "This is shown firstly by letter in relation to the starting note followed by a number in rounded brackets (in this case C(0)).", "The number in rounded brackets (counted in semitones) denotes the pitch by a number which has been found by first taking the actual pitch and reducing it to a number between ‘0’ and ‘11’ by subtracting/adding by multiples of 12.Musically, this means all the theoretical pitches have all been moved into the range of one octave.", "Lastly, in square brackets indicates the actual pitch.", "The boxes inside the circle denote the number of sharps or flats that a key contains.", "Flats are represented by negative numbers while sharps are represented by positive numbers.", "Each key can only contain sharps or flats but not both (i.e., a number cannot be both positive and negative).", "Any key can contain any integer number of flats/sharps ranging from −∞ to ∞.", "All keys represented are denoted by their major root (tonic).", "As the theoretical modulation occurs, any notes at a particular position on the circle will sound the same as any other note at the same position in the circle.", "For example, A[21] at position “3 o'clock” of diagram 2, sounds the same as Bbb[−63] which would also lie at “3 o'clock” if continued to show the modulation circle in the flat direction.", "A modulation in the sharp direction adds one flat (or decreases one sharp) and adds seven theoretical upwards semitones (theoretical because due to the cyclic nature of octaves, when considering octave-independent aspects of music such as key, any pitch can remain unchanged by adding/subtracting multiples of 12).", "Meanwhile, a modulation in the flat direction subtracts one flat and adds seven theoretical downwards semitones.", "Any key taken “out of theoretical context” can be expressed by using no more than 6 sharps or flats.", "Any modulation can be expressed as both a flat modulation and a sharp modulation.", "This can be represented visually as moving both ways around the circle of fifths.", "As it happens, the sum of the moduli of these 2 directions adds up to 12.For example, looking at the circle in FIG.", "5, modulating from C to G can either occur by moving 1 step clockwise, or 11 steps anticlockwise (1+|−11|=12).", "A modulation algorithm according to one embodiment, will handle this kind of “enharmonic modulation” by choosing the modulation that requires the least movement around the circle.", "From the above discussion of how keys are related, modulation may be detected by finding out-of-scale note pitches.", "For example, given the scalic base list of intervals, (2,2,1,2,2,2,1), one can detect that a modulation has occurred when a pitch that does not fit in with this framework is encountered.", "Let the scalic base pitch here be 0.Then by the semitonal interval framework (2,2,1,2,2,2,1) and considering only one octave, semitones (0,2,4,5,7,9,11) will all be in-key.", "Semitones (1,3,6,8,10) will be out-of-key and will signify that a modulation has occurred.", "These out-of-key semitonal pitches each have a “degree of sharpness or flatness” that can be counted.", "When detection of a modulation has occurred, this modulation may be found by finding the key that requires the least movement around the circle in FIG.", "6 to accommodate all of the out-of-key pitches.", "To aid in finding this key, a table can be created for the degrees of sharpness and flatness by going through this process for each single out-of-key pitch within the range of one octave.", "For example, a table of semitones 1, 3, 6, 8, 10 is illustrated in FIG.", "6.For any “out-of-key” pitch, let fN equal the least number of keys moved in a flat direction from the original key until the new pitch is found (the number of flats that need to be added to the original key to get to the first new key that the “out-of-key” pitch is denoting via the flat direction).", "For any “out-of-key” pitch, let sN equal the least number of keys moved in a sharp direction from the original key until the new pitch is found (the number of sharps that need to be added to the original key to get to the first new key that the “out-of-key” pitch is denoting via the sharp direction).", "For a group of “out-of-key” pitches, the flat modulation weight is the sum of all fN and the sharp modulation weight is the sum of all sN.", "The Highest Change Flat is the highest fN and the Highest Change Sharp is the highest sN.", "For example, a C major has two out-of-key pitches, one lying 3 semitones above C and one lying 6 semitones above C. Pitch 3 is first examined.", "Looking at the table above, 2 keys can be traveled around on the circle in a flat direction until a new pitch is found.", "Therefore, fN=2.In the sharp direction, 4 keys around the circle can be traveled in the sharp direction until the new pitch is found.", "Therefore, sN=4.Looking at pitch 6, 5 keys around the circle can be traveled in a flat direction until the new pitch is found.", "Therefore fN=5.Traveling 1 key around the circle in a sharp direction can be performed to find the new pitch.", "Therefore sN=1.The flat modulation weight in this case is 2+5=7 while the sharp modulation weight is 4+1=5.The Highest Change Flat is the greater number of {2,5} =5 and the Highest Change Sharp is the greater number of {4,1}=4.The concept of out-of-key pitches themselves having a degree of sharpness and flatness can be used to determine which way around the circle of fifths to modulate.", "According to an embodiment, a group of pitches including out-of-key pitches may be analyzed for modulation.", "Notes that are separated from other notes in the group by multiples of octaves (12 semitones) should be removed to maintain only one note for each particular pitch name in each group.", "Information about this group of pitches including the modulation weight, the sharp modulation weight, the highest change flat, and the highest change sharp, as described above, are determined.", "As mentioned above, the least amount of movement possible by which all “out-of-key” notes can be found in a new key are desired.", "If the flat modulation weight is less than the sharp modulation weight, a flat modulation is performed.", "If the sharp modulation weight is less than the flat modulation weight, a sharp modulation is performed.", "If the flat modulation weight equals the sharp modulation weight, no modulation is needed.", "When modulating in the flat direction, the amount of keys to move is equal to the highest change flat.", "When modulating in the sharp direction, the amount of keys to move is equal to highest change sharp.", "From the earlier example of a group of out-of-key pitches to be 3 and 6 semitones above our starting key base note, the following values have been determined: flat modulation weight=7 sharp modulation weight=5 highest change flat=5 highest change sharp=4.The sharp modulation weight is less than the flat modulation weight, and as such, a modulation in the sharp direction may be performed.", "A move of 4 places around the circle of fifths in the sharp direction may be performed to find the new key (or adding 4 sharps to the current key signature).", "The flat modulation weight is equal to the sum of how far to travel to get to Bb Major (1st key containing Eb in flat direction) and how far to travel to get to Db Major (1st key containing pitch Gb).", "The sharp modulation weight is equal to the sum of how far to travel to get to E Major (1st key containing D# in sharp direction) and how far to travel to get to G Major (1st key containing F#).", "The Highest Change Flat is the number of flats that have to be added to C Major to get to Db Major.", "The Highest Change Sharp is the number of sharps that have to be added to C Major to get to E Major.", "According to an embodiment of the present invention a combination of forward and backwards analysis techniques are used for the key analysis of a musical piece.", "Forward analysis is a technique, according to one embodiment of the present invention, used to analyze and process a key sequence by scanning through a musical piece chronologically and, when out-of-key pitches are found, the modulation method described above is used to determine a key change.", "The analysis may begin in the key of the base scale note at time 0.When notes with out-of-key pitch(es) are identified, modulation is performed and the key of the musical piece is set to a new key according to the modulation found.", "This process may be performed for the entirety of a musical piece.", "For example, reference is made to the following string of note information: [0,4,0] [4,8,7] [8,10,6] [10,14,9] [14,16,7] [16,20,5] [20,22,4] [22,24,2] [24,28,0].", "The first number in the square brackets denotes the starting time of the note.", "The second number in the brackets denotes the ending time of the note.", "The third number in the brackets denotes the pitch relative to 0.This example starts off in key 0 (C major).", "At time 8, a semitonal pitch 6 is detected which is out-of-key.", "A modulation of 1 key sharp is determined and identifies a new key of 7.In musical terms, C major is the starting key and at time 8, an F# is encountered so modulation to G major is performed.", "At time 16, a note with pitch 5 is detected which is out-of-key in comparison to key 7.A modulation of 1 key flat is determined and identifies the key is once again 0.In musical terms, at time 16, an F natural is encountered and modulation back to C major is performed.", "It may be determined that no out-of-key notes occur again in relation to 0 for this string of note information.", "Thus, by forwards analysis, the resulting key sequence may be as follows where the first number in the brackets denotes the start times of the keys and the second number in the brackets is the semitonal key base pitch: [0,0] [8,7] [16,0] Backwards analysis refers to the process of analyzing a key sequence similar to the forward analysis described above but in reverse-chronological order.", "In other words, the analysis is performed in the same manner as the forwards analysis but instead progresses from end time to start time rather than from start time to end time.", "Progressing backwards, it is the end times of the notes rather than the start times which will provide the “start times” of the new keys.", "From the forward analysis example, the string of note information was, [0,4,0] [4,8,7] [8,10,6] [10,14,9] [14,16,7] [16,20,5] [20,22,4] [22,24,2] [24,28,0].", "Reversing this sequence, produces: [24,28,0] [22,24,2] [20,22,4] [16,20,5] [14,16,7] [10,14,9] [8,10,6] [4,8,7] [0,4,0].", "With a scale base of C major (0), analysis begins at 0.Traversing through the reversed list, at time 10, a semitone 6 which is out-of-key in comparison to 0 is detected.", "Therefore at time 10, the piece modulates to a key with semitone 7 as the base note.", "In musical terms, at time 10, an F# is detected and the key modulates to G Major.", "After time 10, moving chronologically backwards, it is determined that no additional out-of-key notes occur in relation to the key with key base note 7.Analyzing backwards, the piece ends in C Major.", "From time 10 until time 0, there is no note pitch that is out-of-key for G Major and therefore the piece stays in G Major until the end of the note string.", "Therefore, by backwards analysis, the resulting key sequence may be as follows where the first number in the brackets denotes the start times of the keys when moving in a reverse chronological order from the end of the piece to the start and the second number in the brackets is the semitonal key base pitch: [28,0] [10,7].", "Once this key sequence is determined, it may then be reversed to obtain a backwards-analyzed key sequence in chronological order for key analysis of a musical piece.", "Taking the example sequence [28,0] [10,7], this can be reversed to obtain a backwards-analyzed key sequence n chronological order of [0,7] [10,0].", "This method of forward and backward analysis allows analyzing both the gradual kind of modulation that is seen in many genres of classical music as well as the more sudden kind of modulation that is seen in a lot of rock and pop music.", "At the start of these modulations, the music often actually exists in two keys at once so and as such, the overlying chord sequence repetitions are analyzed in order to detect the most likely key sequence.", "The key analysis may generate a list of all the chord sequence numbers according to the modulations detected by each of the forward and backward analyses.", "During this stage, chordal analysis (discussed in further detail below) may be performed in order to determine the most suitable key sequence as derived from the forwards and backwards analysis.", "Chord sequences may be generated from the key sequences of a musical piece after forward and backwards analyses.", "As discussed above, a chord represents a framework for pitches that can sound harmonically together in a given key.", "The following is an exemplary chord sequence associated with a key sequence after forward analysis: 1,6,3,7,4,6,3,7,5,3,7,7,4,6,3,7.Analyzing the same musical piece using backwards analysis, the following chronologically-reversed chord sequence may be produced: 7,3,6,1,7,3,6,1,6,6,6,1,7,3,6,1.Inverting the above chord sequence back to chronological order produces the following backwards-analyzed chord sequence: 1,6,3,7,1,6,6,6,1,6,3,7,1,6,3,7.Once the forward and backwards-analyzed chord sequences are obtained, the places in which the chord sequence generated from the forward analysis bifurcates (is in two keys at once) from the inverted chord sequence of the backwards analysis are determined.", "From these two chord sequences, the following illustrates how it can be seen where chord sequences bifurcate.", "4, 3,7,5,3,7, 4, 1,6,3,7, 6, 7, 6,3,7.1, 6,6,1,6,3, 1, Using the example above, a comparison of the two chord sequences result bifurcations consisting of an “upper” bifurcation (from the forward analysis) and a “lower” bifurcation (from the inverse backward analysis).", "The upper bifurcation includes [4], [3,7,5,3,7], [4] and the lower bifurcation includes [1], [6,6,1,6,3], [1].", "In a next step, all possible full chord sequences are enumerated across all bifurcation combinations.", "Each “fork” is analyzed to find the most frequently occurring chordal repetitions.", "The forks of the above bifurcation are UUU→1,6,3,7,4,6,3,7,5,3,7,7,4,6,3,7 UUD→1,6,3,7,4,6,3,7,5,3,7,7,1,6,3,7 UDU→1,6,3,7,4,6,6,6,1,6,3,7,4,6,3,7 UDD→1,6,3,7,4,6,6,6,1,6,3,7,1,6,3,7 DUU→1,6,3,7,1,6,3,7,5,3,7,7,4,6,3,7 DUD→1,6,3,7,1,6,3,7,5,3,7,7,1,6,3,7 DDU→1,6,3,7,1,6,6,6,1,6,3,7,4,6,3,7 DDD→1,6,3,7,1,6,6,6,1,6,3,7,1,6,3,7.The ‘U’ denotes the upper bifurcation and the ‘D’ denotes the lower bifurcation.", "Each fork may then be analyzed and the most frequently occurring chordal repetitions or sub-sequences (e.g., 1,6,3,7) are identified.", "The most frequently occurring sub-sequences are calculated to determine which “side” of the bifurcation is the most likely one to contain a key sub-sequence with the best “fitness.” For all possible chord sub-sequences within these full chord sequences, fitness values are calculated where fitness=sub-sequence length*frequency.", "That is, the fitness score is equal to a given sub-sequence length multiplied by its frequency of occurrence.", "Each chord sub-sequence may be weighted equally.", "For example, a sub-sequence that is not in a bifurcated area should have a reduced “weight” in the analysis as it is being analyzed multiple tunes (the 1,6,3,7 that begins all sequences should not be counted 8 times).", "The fitness value may be multiplied by 2m/2n to get a weighted fitness value, where ‘m’ is the number of bifurcations in a given sub-sequence and ‘n’ is the total number of bifurcations.", "In the current example, n=3.The beginning chords 1,6,3,7 includes no forked sub-sequences which results in m=0.On the other hand, a sub-sequence including the first 5 chords, 1,6,3,7,4 has a chord from one fork and therefore, m=1.A chord sub-sequence with the highest weighted fitness value is determined.", "If there is more than one sub-sequence with the same fitness, one of those chord sub-sequences may be chosen randomly.", "In this instance, it may be determined from calculating the weighted fitness values the sub-sequence 1,6,3,7 is the most frequently occurring chord sub-sequence of length 4.In addition, the sub-sequence length of 4 allows creating 4 consecutive instances the sub-sequence, which would entirely fill the whole 16 chord sequence.", "In order to accommodate this chord sequence, the choice of key sequence bifurcations (the bifurcation “route”) is D, U-D, D, where in the middle bifurcation, the key changes from the upper fork to the lower one at the time of the start of the third chord in the bifurcation.", "Going back to the bifurcation representation, 4, 3,7,5,3,7, 4, 1,6,3,7, 6, 7, 6,3,7, 1, 6,6,1,6,3, 1, the following chord sequence may be created from the key analysis using the 1,6,3,7 sub-sequence: 1,6,3,7,1,6,3,7,16,3,7,1,6,3,7.The analyzed key sequence may be set according to the above chord sequence.", "The key sequence is set to ensure that the bifurcation route fully accommodates all instances of the new chord sequence.", "In other words, the key sequence must be such that this chord sequence can exist in all its instances.", "The produced key sequence may be standardized to start with a key of 0 (if necessary).", "This allows it to be stored and used in combination with other standardized key sequences.", "To do this, the first key of the sequence may be transposed to 0 and the rest of the keys are transposed accordingly by the same transposition of the first key.", "A note can then be made of the transpositional difference so that it can be re-transposed at output if required.", "This will enable the original keys to be preserved.", "A large amount of mid-Baroque music may lie in keys with 0-3 accidentals, whereas 20th Century pieces may contain more keys with more accidentals.", "Key sequences may be analyzed starting in a key with no accidentals (C major/A minor/Aeolian etc.", "), however, the re-transposing can preserve this stylistic approach to using the different keys.", "Chord A next step of vertical analysis focuses on chord sequences in relation to each key.", "According to one embodiment, chord analysis may take place “inside” the key analysis.", "During the key analysis stage, chord analysis may be performed in order to determine the best/fittest key sequence refine the key sequences from the key analysis stage).", "For example, key analysis may produce several possible key sequences.", "For each of these, chord analysis may be performed in order to aid in determining the best/fittest key sequence.", "Chord analysis may also take place after the key sequence is finalized, in which case a more accurate but less efficient algorithm may be employed in order to determine more accurate results.", "Chordal analysis may be employed to write chord sequence blocks to the music builder's database and use them along with chord frames to create new chord sequences.", "According to an embodiment, chordal analysis may include traversing through a piece of music chronologically, creating, updating, and saving “ghost chords” to generate new chord sequences.", "Ghost chords are temporary chords that are updated throughout a particular chordal analysis until they become finalized, at which point the chord is “saved” to an output sequence.", "A ghost chord may initially include a dynamic and/or non-definite harmony that may change across time and become a definite chord when analysis of a sequence of notes for the ghost chord has finished.", "Chordal analysis may include examining sets of notes chronologically, creating, updating and finalizing ghost chords while following certain rules and accounting for “essential fragments” and “inessential fragments.” An essential fragment is a note or part of a note that adds its pitch value to a ghost chord.", "Inessential fragments are notes or parts of a note whose pitch is ignored in the chordal analysis (covering the non-harmony parts of traditional non-harmony structures such as passing, suspension, pedal, etc.).", "An inessential fragment may be defined as a note or a section of a note that does not add to the harmony.", "It may also encompass all different traditional non-harmony notes.", "Identification of inessential fragments are subject to the following requirement: the fragment of the note in question is flanked on at least one side by an essential fragment with a pitch difference between the two notes less than or equal to 2 semitones.", "Inessential notes may characterize non-harmony notes such as “passing notes” and “suspensions,” where their pitches do not affect overall harmony.", "The chordal analysis is contributed to by the pitches of any note fragments that do not qualify as inessential fragments.", "As an inessential fragment should be connected to at least one essential fragment, it can be deduced that for any adjacent three note fragments in a single line (or part), at least one of there must be essential and contributing to the chordal structure.", "A ghost chord is finalized once it contains pitches that fill a predetermined chordal analysis interval.", "Examples of suitable choices for this interval are a scalic 5th or 7th.", "Once a ghost chord is finalized it may not be further updated.", "Any subsequent essential fragment pitches must lie on the triadic intervals within the finalized ghost chord, otherwise, a new ghost chord is created.", "By the process described above, many areas of a musical piece will have a definite chordal definition.", "However, there are instances (more commonly when fewer owes are sounding simultaneously or a higher analysis interval is chosen) in which the chordal definition is ambiguous.", "In this instance, all harmonic possibilities should be evaluated and a fitness function may be employed to guide to a decision for a final result.", "For harmonically ambiguous pitches (one that can either be an inessential fragment or an essential fragment), analysis may need to be “forked” and a fitness function may be applied to all forks generated.", "For example, if there is a passage containing 6 notes that could be described as inessential, 2̂6 different forks of analysis may be created in order to accommodate all possible combinations.", "however, this may be reduced by noting that an inessential fragment must be tied to an essential fragment within its line.", "Therefore, for example, forks of analysis which contain 3 or more consecutive inessential fragments within a line may be eliminated.", "When attempting to update a ghost chord with a pitch whose inclusion results in there being no existence of an inversion of pitches whose highest number of the resultant chord lies within the designated analysis interval, then a transgression of the ghost chord will be caused.", "For example, if the designated analysis interval was a 5th and the pitches contained in the ghost chord were (0(C), 7(G)), then if (11(B)) were added, all of the pitches cannot be contained within an interval of a fifth, and a transgression will be caused.", "A note pitch added to a current ghost chord that causes a transgression may instead be added to a new ghost chord.", "As such, the current ghost chord may be finalized and added to the chord sequence, and a new ghost chord is created for the new note pitch.", "To begin chordal analysis, all notes may be placed into a range of one octave for each line of notes.", "Then any adjacent notes which share the same pitch may be joined together to become a single note.", "An analysis interval may be determined for the ghost chords (this may be determined by user input or an initial heuristic scan).", "A fitness function is determined for evaluation of essential/inessential fragment combinations (this also may be determined by user input or an initial heuristic scan).", "Fitness functions may include either one or a combination of the following goals: to find a chord sequence that has the lowest triadic chordal numbers possible (e.g., standard chords based on triads are preferred to 7th chords which in turn are preferred to 9th chords etc.", "), to find a chord sequence in which the most note pitches (to have as few inessential fragments as possible), and to find a chord sequence that provides the most tempered harmonic rhythm for the piece.", "Chordal analysis includes chronologically iterating through all note start times.", "For each start time, any notes that are held may be temporarily “cut.” This allows deducing note fragments that may be created if a harmonic change is detected at the start time.", "A set of pitches that will sound at each start time is created and the following analysis steps are taken: 1) IF there exists a current ghost chord and all pitches in S can fit within it, filling the analysis interval, OR if all note pitches in S already lie in the ghost chord, then update the current ghost chord with these pitches and continue the iteration, 2) ELSE IF all pitches in S can exist within a new ghost chord, filling the designated analysis interval, then write the current ghost chord (if exists), create a new ghost chord and update it with all pitches in S and continue the chronological iteration, 3) ELSE IF any pitches in S can be described as inessential fragments, analyze all possible combinations of these and apply the fitness function to find the best result (i.e.", "which combination of inessential and essential fragments lead to the fittest chord sequence).", "It may be necessary to “temporarily” analyze further into the piece recursively in order to achieve this.", "Once the optimal combination of inessential/essential fragments has been determined, then write, create and update ghost chords appropriately, 4) ELSE, IF the pitches in S can fit within the current ghost chord, update it.", "ELSE, write the current ghost chord (if one exists), and then create a new ghost chord and update it by all pitches in S (this may push the ghost chord past its designated analysis interval and allows extended chords even in the case of a low analysis interval).", "The following is an exemplary process for performing chordal analysis with reference to the musical piece by as shown in FIG.", "7A.", "The musical piece is analyzed in chronological order (left to right) beginning with the first note using the following parameters: Analysis Interval=5th Fitness Function=Lowest triadic chordal numbers preferred.", "If possibilities with equal lowest triadic chordal numbers are encountered, aim to choose the chord sequence with the most essential fragments contributing to it.", "If possibilities with equal lowest triadic chordal numbers and an equal number of essential fragments are encountered, aim for as tempered harmonic rhythm as possible.", "Ghost chords take the format m[n1, n2 .", ".", ".", "nx] where in is the current overall value of the ghost chord and the n values denote pitches that contribute to the ghost chord.", "Let this be counted in 4 beats per bar with 3 divisions per beat.", "Bar 0, beat 4,3—Has Bb.", "ANALYSIS 1: No ghost chord exists.", "ANALYSIS 2: This cannot fill a new ghost chord with an interval of a 5th.", "ANALYSIS 3: This cannot be an inessential fragment as it is not flanked on either side by a note of pitch difference 2 semitones.", "ANALYSIS 4: The pitch must contribute to the harmony.", "No ghost chord exists so a new one is created and is updated with the pitch.", "The result is Bb[Bb].", "Bar 1, beat 1.1—Has {Eb, G}.", "ANALYSIS 1: This can fill the currently existing ghost chord to the designated analysis interval (5th).", "The result is Eb[Eb, G, Bb].", "Bar 1, beat 1.2—Has {Eb, G, Eb, G}.", "ANALYSIS 1: All of these pitches already lie within the current ghost chord.", "The ghost chord remains as Eb[Eb, G, Bb].", "Bar 1, beat 1.3—Has {Eb, Bb, Eb, G, G}.", "ANALYSIS 1: All of these pitches already he within the current ghost chord.", "The ghost chord remains as Eb[Eb, G, Bb].", "Bar 1, beat 2.1—Has {Eb, Eb, G} ANALYSIS 1: All of these pitches already lie within the current ghost chord.", "The ghost chord remains as Eb[Eb, G, Bb].", "Bar 1, beat 2.2—Has {Eb, Ab, D, F}.", "ANALYSIS 1: This set of pitches cannot update and fill the current ghost chord to the required interval.", "ANALYSIS 2: This set of pitches cannot fill an empty ghost chord to the required interval of a 5th.", "ANALYSIS 3: The Eb, D and all have flanking fragments that are separated by pitch<=2 semitones.", "Therefore all of these pitches at this stage have the possibility of being inessential fragments.", "It cannot be determined how the analysis will develop at this point and will need to create a forked analysis here.", "As there are three pitches here that could or could not be inessential fragments, a combination of 2̂3=8 paths are generated to explore at the next step.", "The following analysis takes place within recursive loops.", "Each instance of this analysis at each time step will have definite values of ghost chords and how they are being updated.", "However, for simplicity, each set of instances per time will now be treated generically and therefore fork-specific ghost chords will not be considered.", "ANALYSIS 4: Dependent on fork of analysis.", "Bar 1, beat 2.3—Has {Eb, B, D, Ab, G} (Cb will have been analyzed previously in the key analysis as a B natural).", "ANALYSIS 1: Regardless of the currently existing ghost chord in this analysis loop, the current notes cannot lie on triadic chordal pitches within the interval of a fifth.", "ANALYSIS 2: This cannot fill a new ghost chord with an interval of a 5th.", "ANALYSIS 3: The Eb, D and G all have flanking fragments that are separated by pitch<=2 semitones.", "Therefore these pitches at this stage have the possibility of being inessential fragments.", "Again, forked branches of analysis are created in order to determine how these possibilities may develop.", "ANALYSIS 4: Dependent on fork of analysis.", "Bar 1, beat 3.1—Has {Eb, F}.", "ANALYSIS 1: These pitches cannot fit into any currently existing ghost chord.", "ANALYSIS 2: They cannot fit into a new ghost chord with an analysis interval of a 5th.", "ANALYSIS 3: Both of these pitches could be classed as inessential fragments.", "Further forks are created in the analysis.", "ANALYSIS 4: Dependent on fork of analysis.", "Bar 1, beat 3.2—Has {Eb, G, Eb, F}.", "ANALYSIS 1: These pitches cannot fit into any currently existing ghost chord ANALYSIS 2: They cannot fit into a new ghost chord with an analysis interval of a 5th.", "ANALYSIS 3: All pitches except for the G could be classed as inessential fragments.", "Therefore, further forks are created in the analysis.", "ANALYSIS 4: Dependent on fork of analysis.", "Bar 1, beat 3,3—Has {Eb, Bb, Eb, G, F}.", "ANALYSIS 1: These pitches cannot fit into any currently existing ghost chord.", "ANALYSIS 2: They cannot fit into a new ghost chord with an analysis interval of a 5th.", "ANALYSIS 3: All pitches except for the Bb and G could be classed as inessential fragments.", "Therefore, further forks are created in the analysis.", "ANALYSIS 4: Dependent on fork of analysis.", "Bar 1, beat 4.1—Has {D, Eb} ANALYSIS 1: These pitches cannot fit into any currently existing ghost chord.", "ANALYSIS 2: They cannot fit into a new ghost chord with an analysis interval of a 5th.", "ANALYSIS 3: Both of these pitches could be classed as inessential fragments.", "Further forks are created in the analysis.", "ANALYSIS 4: Dependent on fork of analysis.", "Bar 1, beat 4.2—Has {D, G, Eb, Eb}.", "ANALYSIS 1: These pitches cannot fit into any currently existing ghost chord.", "ANALYSIS 2: They cannot lit into a new ghost chord with an analysis interval of a 5th.", "ANALYSIS 3: Both of the Eb pitches could be classed as inessential fragments.", "Therefore, further forks are created in the analysis.", "ANALYSIS 4: Dependent on fork of analysis.", "Bar 1, beat 4.3—Has {D, Bb, Eb, G, Bb}.", "ANALYSIS 1: These pitches cannot fit into any currently existing ghost chord.", "ANALYSIS 2: They cannot fit into a new ghost chord with an analysis interval of a 5th.", "ANALYSIS 3: The D and Eb pitches could be classed as inessential fragments.", "Therefore, further forks are created in the analysis.", "ANALYSIS 4: Dependent on fork of analysis.", "Bar 2, beat 1.1—Has {C, G}.", "ANALYSIS 1: This is dependent on a given fork (although by observation, this is not going to be possible in any currently existing fork).", "ANALYSIS 2: They can fit into a new ghost chord with an analysis interval of a 5th.", "Therefore, at Bar 2, beat 1.1, a definite harmony is found.", "This serves as an “anchor” for the harmonic analysis and the recursive forked analysis comes to a close.", "In this passage, 20 pitches have been identified which may or may not be inessential fragments.", "To find all combinations of these, 2̂20 forks of analysis are created, which may then apply the fitness function to in order to determine the correct chord sequence.", "However, this can be reduced.", "As mentioned above, no three inessential fragments can exist next to each other in a line.", "By similar logic, the ties in the left hand manual (organ terminology) cannot both be inessential fragments (as each must be adjoined to an essential fragment).", "Therefore, at points in the recursive analysis in which illegal forks are detected, these forks may be discarded.", "Using the fitness function above which aims to find the lowest chordal triadic numbers, least amount of inessential fragments and most tempered harmonic rhythm, in that order of priority, the following final chord sequence may be produced: Bar 0, beat 4.3−>Bar 1 beat 2.1—Eb (Major), Bar 1, beat 2.2—D (Diminished), Bar 1, beat 2.3—B7 (Diminished), Bar 1, beat 3.1—Bar 2, beat 1.1 Eb (Major).", "On beat 2.2, it may seem that the chord could equally have been Ab (Major) by the “lowest triadic chordal number” criterion, but D (Diminished) was chosen by the “least inessential fragments” criteria as well as the fact that the ‘G,F,G’ in the upper part would all have had to have been inessential fragments to accommodate this.", "On beat 3.1, the chord could equally have been B7 Diminished by the “lowest triadic chordal number” and “least inessential fragments” criteria of the fitness function but Eb was chosen by the tempered harmonic rhythm criterion.", "This method of analysis has generated non harmony pedals (the Eb in the bass under the diminished.", "D diminished & B7 diminished chords) and passing notes (the G in the upper register of Bar 1, beat 2.3, the F in the upper register of Bar 1, beat 3 and the D in the bass of Bar 1, beat 4).", "This example also shows how this algorithm allows for two consecutive inessential fragments (the G and F in the upper register of Bar 1 beat 2.3−>beat 3).", "If an analysis interval of a 7th is used rather than a 5th, Bar 1, beat 2.2 would also have been analyzed as a B7 Diminished chord (there would have been just one chord shared by beats 2.2 and 2.3).", "The ghost chord generated at beat 2.2 D[D,F,Ab] would have been updated to B7[B, D, F, Ab] on beat 2.3.Additionally, the D in the bass of Bar 1, beat 4 would not have been an inessential fragment but would have updated the Eb chord to an Eb7.The reason for choosing an analysis interval of a 5th here is that in general, taking higher analysis intervals means that less ghost chords are filled and additional recursion and forked analysis may be involved.", "According to an alternative embodiment, it is possible to reduce the functionality of the algorithm to achieve greater efficiency whilst achieving acceptable analysis results in certain situations.", "One example of many ways of restricting the algorithm is the following: inessential fragments should be flanked on both sides by a fragment or note of equal or greater length.", "(here the concept of a note is used in addition to that of a note fragment as for this reduced algorithm will be iterating forwards (no recursive forks are required) and hence unable to determine the size of succeeding note fragments at the time of each analysis).", "Also, let no two inessential fragments exist adjacently within a line.", "For each time pitches are encountered that cannot lie within the analysis interval and can be described as inessential fragments, two values are determined, pNum—the number of transgressions the set of note pitches makes with the currently existing ghost chord, and nNum—the number of transgressions the current set of note pitches makes with the ghost chord generated by the next set of note pitches.", "The following rule is used to determine how the inessential fragment affects the chordal analysis: IF pNum<nNum, do not update the current ghost chord, ELSE use the note pitches that occur at the next time in the sequence to update the ghost chord by using ANALYSIS STEP 4.This is may be seen as “hard-coding” a reduced version of the fitness function criteria whose goal is to find a chord sequence in which the most note pitches lie (to have as few inessential fragments as possible).", "The four steps of analysis mentioned previous may therefore slightly modified to the following: ANALYSIS STEP 1: IF there exists a current ghost chord and all pitches in S can fit within it OR IF all note pitches in S already lie in the ghost chord, then simply update the current ghost chord with these pitches and continue the iteration.", "ANALYSIS STEP 2: ELSE IF the number of pitches in S>1 AND all pitches in S can exist within a new ghost chord, then write the current ghost chord (if exists), create a new ghost chord and update it with all pitches in S and continue the chronological iteration.", "ANALYSIS STEP 3: ELSE IF any pitches in S can be described as inessential fragments, find pNum and nNum.", "IF pNum<nNum, continue the time iteration ELSE use ANALYSIS STEP 4 with (S=the pitches that are sounding at the next time in the iteration).", "ANALYSIS STEP 4: ELSE, IF the pitches in S can fit within the current ghost chord, update it.", "ELSE, write the current ghost chord (if one exists) and then create a new ghost chord and add update it by all pitches in S (this may push the ghost chord past its designated analysis interval and allows extended chords even in the case of a tow analysis interval).", "The following is an exemplary process for performing a “reduced” chordal analysis with reference to the musical piece by as shown in FIG.", "7B.", "Bar 1, beat 1—Has {F#}.", "ANALYSIS 4: A new ghost chord, F#[F#] is set up.", "Bar 1, beat 3—Has {B}.", "ANALYSIS 4: The current ghost chord is updated to B[B, F#].", "Bar1 beat 4—Has (B}.", "ANALYSIS 1: ‘B’ already exists in the ghost chord.", "Bar 2, beat 1—Has {A}.", "ANALYSIS 4: The old ghost chord is written and a new one, A[A] is set up.", "Bar 2, beat 2—Has {G}.", "ANALYSIS 3: This can be described as an inessential fragment.", "Here G when compared to the ghost chord A[A]=1.If looking ahead to the next time there is a temporary ghost chord F#[F#].", "Now G when compared with ghost chord F#[F#]=1.Therefore, ANALYSIS STEP 4 is used with the set of pitches {F#}.", "The ghost chord is now updated to [F#A].", "Bar 2, beat 2.5—Has {F#}.", "ANALYSIS 1: This pitch already exists in the current ghost chord.", "Bar 2, beat 3—Has {G}.", "ANALYSIS 4: The old ghost chord is written and set up a new one G[G].", "Bar 3, beat 1—Has {F#}.", "ANALYSIS 3: This can be described as an inessential fragment.", "Here pNum (F#, when compared to the current ghost chord)=1.nNum (F# when compared to the chord generated by the pitches at the next time in the sequence)=0.Therefore, the old ghost chord is written and set up the new ghost chord F#[F#].", "Bar 3, beat 1.5—Has {F#}.", "ANALYSIS 1: This pitch already exists in the current ghost chord.", "Bar 3, beat 3—Has {E, G#}.", "ANALYSIS 2: The old ghost chord is written and a new ghost chord E[E, G#] is set up.", "Bar 3, beat 4.5—Has [A#, E].", "ANALYSIS 2: The old ghost chord is written and set up the new ghost chord A#[A#E].", "Bar 4, beat 1—Has [B, D].", "ANALYSIS 2: The old ghost chord is written and set up the new ghost chord [B,D].", "Bar 4, beat 1.5—Has [F#].", "ANALYSIS 1: This updates the current ghost chord to B[B,D,F#].", "Bar 4, beat 2—Has [B].", "ANALYSIS 1: This already exists in the current ghost chord.", "Bar 4, beat 3—Has [F#,B, C#].", "The start time contains pitches (B and C#) which could be classed as inessential (the B minimum is “cut” here into two crotchets for analysis so this does satisfy the length rule).", "ANALYSIS 3: Here pNum ({F#, B, C#} when compared to the current ghost chord)=1 (i.e.", "1 pitch (C#) conflicts with the current ghost harmony B[B,D,F#].", "Here nNum (F# when compared to the chord generated by the pitches at the next time in the sequence F#[F#,A#,C#]=1 (the ‘B’ conflicts).", "Therefore, the current chord is written and a new chord F#[F#,C#] is set up.", "Bar 4, beat 4—Has [F#, A#, C#].", "ANALYSIS 1: The current ghost chord is updated to #[F#, A#, C#].", "The remaining passage is omitted for brevity.", "The final chord sequence produced may be the following: Bar 1, beat 1−>Bar 2, beat 1—Bminor, Bar 2, beat 1−>Bar 2, beat 3—F#minor, Bar 2, beat 3−>Bar 3, beat 1—Gmajor, Bar 3, beat 1−>Bar 3, beat 3—F#minor, Bar 3, beat 3−>Bar 3, beat 4.5—Emajor, Bar 3, beat 4.5−>Bar 4, beat 1—A#Diminished, Bar 4, beat 1−>Bar 4, beat 3—Bminor, Bar 4, beat 3−>Bar 5, beat 1—F#Major.", "This shows that although the functionality here is greatly reduced (pedals are not detected, and also chronologically consecutive combinations of inessential fragments are not supported), analysis results may be achieved with a simplified algorithm that runs in polynomial time.", "Harmony Analysis From the new chord sequences created from chordal analysis, a determination may be made as to which pitches lie within a given chordal harmony and which do not.", "Pitches that do are recorded as harmony pitches and those that do not are recorded as non-harmony pitches.", "For non-harmony pitches, information such as the previous scale number in the line (unlimited, not cyclic), the current scale number in the line (unlimited, not cyclic), the next scale number in the line (unlimited, not cyclic), the previous chord, the current chord, the next chord, the previous key, the current key, the next key, and the set of other sounding scalic numbers may be recorded and used to determine new possible pitches in the creation of new music.", "Previous, current and next refer to the boundaries of the inessential fragments analyzed during chordal analysis.", "This information may be used to determine which kinds of non-harmony pitches are stylistically allowed from the input and a set of criteria for allowed non-harmony pitches for use during the recreation stage, which is described in further detail below.", "This particular set of information may be the least amount of required information that can satisfactorily preserve the “flavour” of the non-harmony pitch that can then be reproduced when producing new music.", "For example, with values of PrevKey=D, Current Key=D, Next Key=D, PrevChord=Bmin, CurrentChord=F#, Next Chord=F#, PrevScalicNumber=6, CurrentScalicNumber=6, NextScalicNumber=5#, Other Sounding Scalic Numbers =[3,7].", "Therefore, there is no key change and this is a 4-3 suspension (as traditionally expressed by scalic number within chord rather than key) in the chord of F# having come from the chord of B Minor.", "Also, at the time of the suspension, chordal pitches 1 and 5 are also sounding.", "Horizontal Analysis—Movement Patterns and Movement Combinations Whereas vertical analysis pertains to the relationships between multiple simultaneously sounding notes, horizontal analysis pertains to the patterns within a series of notes that do not sound simultaneously.", "This may be the analysis of patterns that exist within one musical “part” or played by a solo instrument.", "It is worth noting that if the input “part” had multiple simultaneously sounding notes (e.g., a piano or double-stopping violin), these would have been split into “lines” of independently sounding voices at the stage of input preparation.", "A comparison of the analysis of these individual musical parts may also be made.", "For example, rhythms that are repeating across all parts may be identified.", "Rhythm Rhythm analysis includes the analysis of repeating rhythms within the individual musical parts.", "The rhythm may be stored as a sequence of integers that represent the note lengths of the rhythm.", "For example, each note may be examined for each separate line (part) of music.", "If an examined note is the first note in the line, a new rhythm sequence is created and the note's length is added.", "If it is not the first note in the line, check if the preceding note in the line has an end time that is equal to the current note's start time.", "If this is the case, the current note's length is added to the current rhythm sequence.", "Otherwise, a new rhythm sequence is created and the current note is added to it.", "A new rhythm sequence provides a framework of pitch empty notes that can be used in the “population” stage of music recreation, which is described in further detail below.", "Movement Patterns Movement patterns may be a term used to describe the way that a musical part moves upwards and downwards, and is important for the successful writing of imitative music.", "The basic idea of a movement pattern is that it describes the “shape” of a musical motif in terns of upwards, downwards and non-changing movements.", "Considering a musical example illustrated in FIG.", "8 it can be seen that the first note is higher than the second.", "The third note is as high as the first note and is therefore higher than the second.", "The fourth note is lower than three preceding notes etc.", "The music builder can record this kind of movement pattern a sequence of positive integers with the lowest note denoted as 1.Looking at the first bar of the example, the lowest note is the fourth note, D. With “x” denoting pitches to be completed, the following is produced: x,x,x,1,x,x,x.", "Next, a F sharp is at the second note.", "The pattern is now x,2,x1,x,x,x,x The next highest pitch , a G which occurs at places 1, 3 and 8.The pattern is now 3,2,3,1,x,x,x,3 The A at position 6 updates the pattern to 3,2,3,1,x,4,x,3 Then the B flat at position 7 updates the pattern to 2,3,1,x,4,5,3 Finally, the highest note, the top D completes the pattern 3,2,3,1,6,4,5,3 Using the same system of analysis on the first seven notes of bar 2, produces: 3,2,3,1,6,4,5 (which matches that of the first bar).", "Range Range dictates the lowest and highest notes for each of the individual musical parts (for example, in a choir, the soprano part will have a generally higher range than the bass which will have a low range).", "The range describes the upper and lower bounds for the possible pitches of each musical part or voice.", "For example, a keyboard instrument that is input as a MIDI track may have many different simultaneously sounding notes but overall, the instrument as a whole has a definite range.", "Range analysis includes identifying the lowest pitch and the highest pitch for each track.", "The recorded inclusive interval between them is the range of the part.", "Range analysis can be used in the “population” stage of music recreation.", "The population step may start with a new “pitch empty” rhythm sequence.", "For each note, the note may be fully populated with pitches bounded by the range of the line in which the note lies.", "Movement Combination Rules Movement combinations may be used by the music builder for “part writing.” This is the way in which pitches are chosen that are consistent vertically with the underlying chordal structures of the notes as well as acceptable horizontally, both within their own lines (to be smooth) as well as in their relationships with the other simultaneous horizontal movements (e.g., to avoid genre-specific part writing problems such as parallel 5ths).", "There are nine types of movement combinations that the music builder may analyze.", "These can be divided into three subgroups.", "The nine types and their respective subgroups are listed below.", "FULL Full Semitonal Full Scalic Unbound Full Scalic Bound SINGLE Single Semitonal Single Scalic Unbound Single Scalic Bound PART DEPENDENT SINGLE Part Dependent Single Semitonal Part Dependent Single Scalic Unbound Part Dependent Single Scalic Bound A “full” is used to describe a movement combination that takes the movements of all currently changing notes into account.", "An example is shown with reference to FIG.", "9.The diagram above shows three full movement combinations.", "The first takes place immediately preceding the 2nd beat of the bar.", "Here, an E goes to another E in the top line and a C goes to a C in the middle line.", "The bottom e does not contribute to the movement combination as there is no movement at that time.", "The second takes place immediately preceding the 3rd beat of the bar.", "Here, an E goes to a D in the top line, a C goes to a B in the middle line and a C goes to a G in the bottom line.", "The third takes place immediately preceding the 4.5th beat of the bar.", "Here a D goes to a C in the upper part, a B goes to a C in the middle part and a G goes to a C in the bottom part.", "A “single” is used to describe a movement combination that only takes into account one linear movement at each time change.", "It describes the movement only within one line.", "The diagram in FIG.", "10 shows eight single movement combinations.", "The first movement combination here takes place in the top line immediately preceding the 2nd beat.", "Here an E goes to another E. The second movement combination here takes place in the top line immediately preceding the 3rd beat.", "Here an E goes to a D. The third movement combination here takes place in the top line immediately preceding the 4.5th beat.", "Here a D goes to a C. The fourth movement combination here takes place in the middle line immediately preceding the 2nd beat.", "Here a C goes to another C. The fifth movement combination here takes place in the middle line immediately preceding the 3rd beat.", "Here a C goes to a B.", "The sixth movement combination here takes place in the middle line immediately preceding the 4.5th beat.", "Here a B goes to a C. The seventh movement combination here takes place in the bottom line immediately preceding the 3rd beat.", "Here a C goes to a G. The eighth movement combination here takes place in the bottom line immediately preceding the 4.5th beat.", "Here a G goes to a C. A “part dependent single” is used to describe a movement combination that only takes into account one specific linear movement at each time change.", "It describes the movement only within one specified line.", "It differs from the single movement combination in that the line is specified.", "For example, a part dependent single movement combination analyzed in a soprano part cannot be used in the bass part in the recreation process.", "Again referring to FIG.", "10, a part dependent single similar to the same eight movement combinations as described in the single movement combination section above.", "However, they will now all be part dependent.", "Semitonal is used to describe an analysis of a movement combination that takes place on a semitonal rather than scalic basis.", "Using the single movement combination as shown above with reference to FIG.", "10 as an example, the first movement combination listed above in the top line from E→E has a semitonal difference of 0.The second movement combination listed above in the top line from E→D has a semitonal difference of −2.The third movement combination listed above in the top line from D→C has a semitonal difference of −2.The fourth movement combination listed above in the middle line from C→C has a semitonal difference of 0.The fifth movement combination listed above in the middle line from C→B has a semitonal difference of −1.The sixth movement combination listed above in the middle line from B−>C has a semitonal difference of +1.The seventh movement combination listed above in the bottom line from C G has a semitonal difference of −5.The eighth movement combination listed above in the bottom line from G→C has a semitonal difference of +5.Now removing duplicates, for this passage, six single semitonal movement combinations with pitch differences −5, −1, 0, +1 and +5 are identified.", "Scalic unbound is used to describe analysis of a movement combination that takes place on a scalic basis rather than a semitonal one and also that the scale degree is not preserved.", "Again, the single movement combination as shown above with reference to FIG.", "10 is used as an example.", "As described in previous sections, the music builder may only use the Major Scale with interval separations (2,2,1,2,2,2,1) as its scalic basis.", "Therefore, this fragment of music will be analyzed with scale base=7 or in traditional musical terms, in G Major.", "The first movement combination listed above in the top line is from E→E.", "In scalic terms relating to G Major, this is scale degree 6→6.The scalic difference is 0.The second movement combination listed above in the top line is from E→D.", "In scalic teens relating to G Major, this is scale degree 6→5.The scalic difference is −1.The third movement combination listed above in the top line is from D→C.", "In scalic terms relating to G Major, this is scale degree 5→4.The scalic difference is −1.The fourth movement combination listed above in the middle line is from C→C.", "In scalic terms relating to G Major, this is scale degree 4→4.The scalic difference is 0.The fifth movement combination listed above in the middle line is from C→B.", "In scalic terms relating to G Major, this is scale degree 4→3.The scalic difference is −1.The sixth movement combination listed above in the middle line is from B→C.", "In scalic terms relating to G Major, this is scale degree 3→4.The scalic difference is +1.The seventh movement C combination listed above in the bottom line is from C→G.", "In scalic terms relating to G Major, this is scale degree 4→1.The scalic difference is −3.The eighth movement combination listed above in the bottom line is from G→C.", "In scalic terms relating to G Major, this is scale degree 1→4.The scalic difference is +3.Now removing duplicates, for this passage, five single scalic unbound movement combinations with pitch differences −3, −1, 0, +1 and +3 are identified.", "Scalic bound is used to describe the analysis of a movement combination that takes place on a scalic basis rather than a semitonal one and also that the scale degree is preserved.", "It differs from scalic unbound in that the actual scale degrees on either side of the note change are preserved, not only the difference between them.", "Again using the single movement combination with reference to FIG.", "10, here a scale base=7 or G Major is used.", "The first movement combination listed above in the top line is from E→E.", "In scalic terms relating to G Major, this is scale degree 6→6.So the information required for this movement combination is explicitly (6 (0)) where the second number in the brackets denotes the scalic movement from the beginning scalic pitch.", "The second movement combination listed above in the top line is from E→D.", "In scalic terms relating to G Major, this is scale degree 6→5.So the information required for this movement combination is explicitly (6 (−1)) where the second number in the brackets denotes the scalic movement from the beginning scalic pitch.", "The third movement combination listed above in the top line is from D→C.", "In scalic terms relating to G Major, this is scale degree 5→4.So the information required for this movement combination is explicitly (5 (−1)) where the second number in the brackets denotes the scalic movement from the beginning scalic pitch.", "The fourth movement combination listed above in the middle line is from C→C.", "In scalic terms relating to G Major, this is scale degree 4→4.So the information required for this movement combination is explicitly (4(0)) where the second number in the brackets denotes the scalic movement from the beginning sale pitch.", "The fifth movement combination listed above in the middle line is from C→B.", "In scalic terms relating to G Major, this is scale degree 4→3.So the information required for this movement combination is explicitly (4(−1)) where the second number in the brackets denotes the scalic movement from the beginning scalic pitch.", "The sixth movement combination listed above in the middle line is from B→C.", "In scalic terms relating to G Major, this is scale degree 3→4.So the information required for this movement combination is explicitly (3(+1)) where the second number in the brackets denotes the scalic movement from the beginning scalic pitch.", "The seventh movement combination listed above in the bottom line is from C→G.", "In scalic terms relating to G Major, this is scale degree 4→1.So the information required for this movement combination is explicitly (4(−3)) where the second number in the brackets denotes the scalic movement from the beginning scalic pitch.", "The eighth movement combination listed above in the bottom line is from G→C.", "In scalic terms relating to G Major, this is scale degree 1→4.So the information required for this movement combination is explicitly (1(+3)) where the second number in the brackets denotes the scalic movement from the beginning scalic pitch.", "There are no duplicates here therefore, for this passage eight single scalic bound movement combinations with scalic movement information (6(0)), (6(−1)), (5(−1)), (4(0)), (4(−1)), (3(+1)), (4(−3)) and (1(+3)) are identified.", "Key and Chord Combination Rules Further additional analysis may be performed to determine which chords can be connected together when generating new music.", "This analysis may be used to select which blocks of chord sequences may be placed adjacently in a chord block frame and in relationship to the underlying key sequence.", "According to one embodiment, a method for analyzing key and chord combinations includes examining a given key and chord sequence from music input (e.g., after vertical analysis) and for each chord, the available chords that can follow the chord and a difference in key at the time of the chord change are identified.", "A set of key and chord combination rules may be established from the examination of the given key and chord sequence.", "A key and chord sequence listed in the diagram of FIG.", "11 produces a traditional chord sequence of: C Major, G Major, D Minor, A Minor, C Major, G Major, A Minor, and G Major.", "Chord combination objects in the format of [(X){a .", ".", ".", "z}(1 .", ".", ".", "9)] may be created for each chord where (X) represents the master chord, {a .", ".", ".", "z} is a list of possible following chords and (1 .", ".", ".", "9) is the respective key difference per following chord.", "In this example, as the chord number is 1, an initial chord combination of [(null){1}(null)] may be.", "Next, starting on the first chord moving to the next chord, a chord change of 1→5 is identified, where the key does not change.", "A chord combination object of [(1){5}(0)] is created.", "Next, the chord changes from 5→2.where the key does not change, creating a chord combination object of [(5){2}(0)].", "A next chord change of 2→6 where the key does not change is identified and a chord combination object of [(2){6}(0)] is created.", "The next chord change of 6→1 where the key does not change produces [(6){1}(0)].", "Next a chord change of 1→5 where the key does not change is identified.", "An existing chord combination object has already been created to reflect this change and hence does not need to be created.", "A next chord change of 5→2 is identified where the key changes from 0→7.The previous chord combination created with master chord=5 is updated to [(5){2,2}(0,+7)].", "This indicates that chord 5 can be followed by chord 2 within the same key or chord 2 in a key +7 semitones higher.", "Next, a chord change 2→1 where the key does not change is identified.", "The chord combination with master chord=2 is updated to [(2){6,1}(0,0)], which indicates that chord 2 can be followed by either chord 6 or chord 1 within the same key.", "Finally, at the end of the sequence, it needs to be shown that chord 1 can lead to the end of the piece.", "The chord combination with master chord=1 is updated to [(1){5,null}(0,null)].", "Therefore, the full set of chord combinations from analysis of this example is: [(null){1}(null)] [(5){2,2}(0,+7)] [(2){6,1}(0,0)] [(6){1}(0)] [(1){5,null}(0,null)] Frame Analysis Blocks Blocks are subsequences of abstract data that can be used to find frames of repetition.", "They can also be manipulated within frames of repetition in order to create new sequences of abstract data.", "A list of all possible subsequences of the initial sequence (where the elements of the subsequence must be adjacent elements of the initial sequence) may be made.", "If the list is too large, the sequence can be split in a random or chosen place and then derive all possible subsequences from the resulting two separate lists.", "For example, let an initial sequence be the numerical string, 1,2,3,4,5 Then taking all possible subsequences of this sequence produces the following: (1), (1,2) (1,2,3) (1,2,3,4) (1,2,3,4,5) (2), (2,3) (2,3,4) (2,3,4,5) (3) (3,4) (3,4,5) (4)(4,5) (5) Now for optimization purposes, in some situations the full initial sequence may have to be broken into smaller sequences for frame analysis.", "To demonstrate this, a split in the sequence is placed between numbers 3 and 4.This is presented by the following subsequences of the two new sequences: (1) (1,2) (1,2,3) (2) (2,3) (3) (4) (4,5) (5) Frames Frames may be generated from the set of blocks to provide a framework in which different blocks may be substituted to create new sequences of abstract data.", "Generating frames includes finding a repetition of blocks with the greatest “fitness” from a set of blocks derived from an ordered sequence of abstract data as analyzed from a music input.", "For example, blocks of possible subsequences may be created from an input data sequence of integers, [1,2,3,4,5,4,5,1,2,3].", "In some embodiments, a “minimum block size” criterion may be desired for excluding blocks of lower sizes.", "In this example, a minimum block size of 2 is configured.", "The full set of blocks with size greater than or equal to the minimum block size will be: {1,2} {1,2,3} {1,2,3,4} {1,2,3,4,5} {1,2,3,4,5,4} {1,2,3,4,5,4,5} {1,2,3,4,5,4,5,1} {1,2,3,4,5,4,5,1,2} {1,2,3,4,5,4,5,1,2,3} {2,3} {2,3,4} {2,3,4,5} {2,3,4,5,4} {2,3,4,5,4,5}) {2,3,4,5,4,5,1} {2,3,4,5,4,5,1,2} {2,3,4,5,4,5,1,2,3} {3,4} {3,4,5} {3,4,5,4} {3,4,5,4,5} {3,4,5,4,5,1} {3,4,5,4,5,1,2} {3,4,5,4,5,1,2,3} {4,5} {4,5,4} {4,5,4,5} {4,5,4,5,1} {4,5,4,5,1,2} {4,5,4,5,1,2,3} {5,4} {5,4,5} {5,4,5,1} {5,4,5,1,2} {5,4,5,1,2,3} {4,5} {4,5,1} {4,5,1,2} {4,5,1,2,3} {5,1} {5,1,2} {5,1,2,3} {1,2} {1,2,3} {2,3} Given the set of blocks, blocks with the highest fitness values are determined.", "According to one embodiment, a fitness score for a given block may be calculated by multiplying the number of times a block repeats in the set of blocks by the number of elements in the block (fitness=number of repetitions of the block*number of elements in the block).", "Alternatively, if the nature of the elements within the block is concerning notes, the fitness score may be calculated by the number of times a block repeats within a music piece, multiplied by the sum of lengths of all notes in the block.", "Another criterion to consider may be a minimum number of repetitions of a block.", "A block that represents the whole sequence may have the highest fitness score, according to the fitness formula, but does not repeat.", "Therefore, blocks with the highest fitness values that do not have the minimum number of repetitions may be disqualified.", "The length of an input sequence may be used as a basis for generating the frame.", "Given the input sequence of 1,2,3,4,5,4,5,1,2,3 is composed of 10 elements, an initial sequence of 10 empty element slots, X,X,X,X,X,X,X,X,X,X may serve as the basis of a frame.", "From the full set of blocks generated from the input sequence, an initial block of highest fitness, {1,2,3} with a fitness score of 6 (the block repeating twice (2) multiplied by the 3 elements in the block) may be selected.", "A common identifier, e.g., “A” may be associated with the elements of the initial block.", "The identifier may be assigned and populated to positions in the frame corresponding to the positions of the elements in the initial block in the original input sequence.", "In this example, the frame will become {A,A,A}X,X,X,X{A,A,A}.", "Additional blocks of highest fitness may continue to be selected if it is determined that the frame allows for further repetitions in the remaining slots of the frame.", "Remaining (unassigned) slots may be populated with blocks until all slots of size greater than the minimum block size have been assigned or are unable to be assigned.", "In the current example, the frame allows for further block repetition.", "No blocks that overlap with already assigned time slots may be selected.", "Any blocks that overlap with already assigned slots are excluded.", "The available blocks for analysis are reduced to: {4,5} {4,5,4} {4,5,4,5} {5,4} {5,4,5} {4,5} As only blocks that repeat at least once are considered, from the reduced set of blocks, the block of highest fitness is {4,5} with a fitness of 4 as there are two instances of it and the size of the block is 2.Therefore, the final frame generated by the analysis will be: {A,A,A} {B,B} {B,B} {A,A,A} In the examples above, all the elements of the sequence are shown as having equal units of time, however, actual data sequences may include time dependent elements of varying lengths.", "Each of the elements in block A and block B may not be the same length as those in subsequent repeated blocks.", "Forked Analysis Suppose an input sequence is 1,2,3,1,2,3,4,3,4,1,2,3.In performing frame analysis according to the steps described above, the block with the highest fitness will be {1,2,3} with a fitness of (3*3)=9.Using this block will produce a final frame of {A,A,A} {A,A,A}X,X,X{A,A,A}.", "However, for example, if block {1,2} with the next highest fitness (2*3=6) was instead chosen as the initial block, then an initial frame of {A,A}X{A,A}X,X,X,X{A,A}X would be produced.", "The remitting empty frame spaces allows for another block of {3,4} to be populated in the empty spaces, producing a final frame of {A,A}X{A,A}{B,B}{B,B}{A,A}X.", "One can see here that the final frame generated using a block with the second highest fitness would actually result in more empty spaces in the frame being assigned.", "Similarly, in situations when multiple highest fitness exists for more than one block, selecting one randomly will not always ensure that the empty frame will be filled to its full potential.", "Therefore, additional frames of varying block fitness scores may be analyzed to generate fuller frames.", "According to one embodiment, multiple frames may be created using blocks of different fitness scores and then compared to determine frames that have been filled to their full potential.", "In the example given above, with sequence 1,2,3,1,2,3,4,3,4,1,2,3, at each step, all frames within an allowed fitness deviation of −3 from the highest fitness score may be generated.", "In addition to the block {1,2,3} with the highest fitness of 9, frames for blocks {1,2} and {2,3} with fitness of 6 may also be generated.", "The following three frames are generated: {A,A}X{A,A}X,X,X,X{A,A}X generated by {1,2} X{A,A}X{A,A},X,X,X,X{A,A} generated by {2,3} {A,A,A}{A,A,A}X,X,X{A,A,A} generated by {1,2,3} After a second iteration of populating the frames with blocks, the following final frames are produced: {A,A}X{A,A}{B,B}{B,B}{A,A}X generated by {1,2} and {3,4} X{A,A}X{A,A}X,X,X,X{A,A} generated by {2,3} {A,A,A}{A,A,A}X,X,X{A,A,A} generated by {1,2,3} After the final frames are determined, a comparison of their full fitness can be determined by counting the number of assigned elements (or empty frame spaces) the sequence.", "In this example, the three frames have full fitness scores of 10, 6 and 9 for the first, second and third frames, respectively.", "From the full fitness scores, it is determined that the first frame has been filled out to the greatest potential of the three.", "Generating Sequences of Abstract Data using Frames and Blocks In the previous sections, analyzing sequences of abstract data (e.g., keys, chords, rhythm, movement patterns, harmony) from input music have been described.", "Methods to find blocks (subsequences) and frames of repetition from these sequences of abstract data have also been described.", "This section now describes how new sequences of abstract data may be recreated using these frames and blocks.", "Alternate subsequences or blocks of musical data can be substituted into the slots and joined together according to rules derived from the order in which the original subsequences were arranged (e.g., combination rules) to create a new sequence of musical data.", "In one embodiment, block combination rules (e.g., key and chord combination rules) may be used to find suitably matching subsequences to put together.", "For example, a plurality of various blocks may be created and a combination of the various blocks which produces the least transgressions when combined together according to the block combination rules may be selected to generate the new sequence of abstract data.", "Finding arrangements of blocks in frames that have minimum transgression of combination rules may be very computationally expensive.", "According to one embodiment, the music builder may use multi-objective genetic algorithms to aid in finding optimal arrangements of blocks within the frames.", "The new sequences of abstract data created may then be used in the process of composing new music.", "Using Part Independent Frames Part independent frames provide a framework of repetition for abstract data structures that are not dependent on the arrangement of musical parts within the piece.", "Examples are key and chord sequences.", "An example of a part independent frame is {[AA][13BB][AA]}.", "This describes that a block of size 2 is placed twice into the sequence and a block of size 3 is placed once into the sequence.", "The following blocks of integer sequences is given.", "{1,2} {2,1} {3,1} {4,5,5} {1,2,4} These may be analogous to part independent abstract data types e.g., key and chord sequences.", "A block of size 2 may be selected at random.", "For example, block {2,1} is selected and is inserted into the ‘A’ slots in the frame.", "The updated frame is now {[2,1][B,B,B][2,1]}.", "Then a block of size 3 is selected at random.", "Block {4,5,5,} may be selected.", "The updated frame may then become {[2,1,][4,5,5][2,1]}.", "As such, a new sequence of {2,1,4,5,5,2,1} may be generated using this process.", "Combination rules can be applied at the “joints” between the blocks to test for fitness.", "The joints of {1−>4} and {5−>2} may be tested.", "This process is analogous to generating a new sequence of part independent abstract data using a part independent frame and blocks derived from the previous analysis.", "Part Independent Key and Chord Blocks and Frames The above discussion of blocks and frames is applied to key and chord sequences.", "According to one embodiment, key sequences may be generated as described in the discussion above.", "However, generating blocks from a chord sequence includes generating blocks of chords within the boundaries of a corresponding key sequence.", "A full set of chord blocks may be generated within the boundaries of the underlying keys.", "For example, a full set of chord frames may be generated from sequences bounded by the keys in a manner as shown by the line between keys 0 and 7 in FIG.", "12.The resulting full set of blocks derived from the key and chord sequence of FIG.", "12 according to the boundary set between the keys may be: {1} {1,5} {1,5,4} {1,5,4,5} {1,5,4,5,1} {5} {5,4} {5,4,5} {5,4,5,1} {4} {4,5} {4,5,1} {5} {5,1} {1} {5} {5,4} {5,4,5} {4} {4,5} {5} Chord sequences should exist independently of the keys that lie beneath them.", "This prevents the chord sequence from being bound to the key of a piece.", "A representation of a chord sequence frame from the chord and key sequence pair example above is shown in FIG.", "13, where the repetitions of the blocks in the frames are generated independent of the underlying keys.", "Key and chord sequences may be generated using frames and blocks, ensuring that adjacently placed blocks cause as few transgressions of the key and chord combination rules as possible.", "These combination rules described earlier in this document and describe which keys and chordal movements are allowable due to the information gained from the analysis of the original input piece.", "Using Part Dependent Frames Part dependent frames may also be used to create sequences of abstract data.", "Examples of data structures that require part dependent frames are rhythm, movement pattern and harmony.", "Part dependent frames allow preservation and creation of contrapuntal patterns in music for musical interplay between different musical parts.", "Part dependent frames for harmony, movement pattern, and rhythm are all generated in a similar manner.", "An example of a diagrammatical representation of a time dependent, part independent frame for a movement pattern sequence is illustrated in FIG.", "14, where the letters denote assigned blocks and the “X”s denote unassigned elements.", "Suppose the following blocks are generated for the movement pattern: {1} {1,2} {2,1} {1,2,3} {1,3,2} {2,1,3} {2,3,1} {3,1,2} {3,2,1} The illustrated movement pattern frame includes three parts (or lines) and is assigned varying time dependent slots.", "For slot A, a two element block may be randomly selected to be {2,1} and the frame representation is shown in FIG.", "15.Due to the nature of a movement pattern, the numbers have meaning when in context with the other movement pattern numbers of their block.", "For slot B, a block which contains three elements is needed.", "The block {3,1,2} may be chosen and updates the frame as shown by FIG.", "16.For slot C, a two-element movement pattern block of {1,2} may be selected, FIG.", "17.Finally, the X slots are filled.", "As the movement pattern only has one one-element block, {1} is selected, and the final movement pattern sequence is shown in FIG.", "18.Harmony Combination Rules With Part Dependent Frames and Blocks In creating new harmony sequences, some rules may be applied when concerning the harmony structure to ensure that non-harmony elements are not placed adjacently within the same lines as this would contravene the rules in chordal analysis.", "For example, according to the chord analysis algorithm, an inessential fragment must lie adjacent to an essential fragment within its line.", "Therefore, harmony combination rules may be employed to ensure that this is always the case in the newly generated harmony sequence.", "Generating Music Using Possible Pitch Reduction and Pitch Locking The new sequences of abstract data that have been generated may now be used to compose new music.", "As a starting point, the rhythm sequence that was generated in the part dependent section of the abstract data generation is selected.", "Population Composing new music may include determining suitable possible pitches for each note in a new rhythm sequence.", "A pitch-empty rhythm structure of a new music piece with two parts consisting of two notes in the lower part (bass) and three notes in the upper part (soprano) is illustrated in FIG.", "19.Each note slot in the rhythm sequence may initially be populated with a full semitonal set of possible pitches.", "The set of possible pitches may include a set of every semitone that lies between the lower and upper bounds of the range of the parts (or lines) within which the note lies, inclusive.", "For example, the range of notes for the soprano part may be 48-60, corresponding to the alphabetic notation of {C,C#,D,D#,E,F,F#,G,G#,A,A#,B,C}, and the part for the bass may range from notes 24-36, corresponding to {C,C#,D,D#,E,F,F#,G,G#,A,A#,B,C}.", "The full list of possible pitches for the two parts may be stored in the rhythm structure as shown in FIG.", "20.Chord and Harmony Reduction The full set of possible pitches for each note may be reduced by discarding pitches that do not conform to the corresponding new generated key and chord sequence.", "According to one embodiment, a chord and harmony reduction may be performed on the possible pitches.", "Each note in the exemplary rhythm sequence may have associated harmony values from its corresponding generated harmony sequence of either harmony (H) or non-harmony (NH) note fragments.", "FIG.", "21 presents harmony values dictated by a harmony sequence associated with the above rhythm sequence.", "The pitches in the rhythm sequence structure may be reduced based on the harmony values from the harmony sequence.", "In addition, FIG.", "22 shows an exemplary key and chord sequence corresponding to the rhythm structure.", "A highest chordal number of a fifth may be selected for the chords in this particular example (7th or 9th chords etc.", "are not considered).", "The chord harmony scalic pitches (or triad) of {1,3,5}, representing the first, third, and fifth notes, may be established as pitches that are located on a chord that are used as a basis in pitch reduction.", "For example, the C Major scale consists of the notes C, D, E, F, G, A, B, and a triad of the C Major chord consists of the C, E, and G notes.", "The possible pitches for harmony notes or notes with an H in the rhythm sequence structure of FIG.", "21 may be reduced by the chord in which they lie.", "A slot in the harmony sequence for the soprano part from t=0 to t=1 is a harmony note.", "The value of H indicates that the note lies within the assigned chord.", "The note corresponds to a key of 0 and a chord of 1 from the key and chord sequence.", "In this example, chord 1 in the key of 0 (C Major) is C Major.", "As discussed above, the triad for the chord of C Major includes the notes of C, E, and G. Possible pitches that do not lie in the triad of C Major may be discarded.", "Therefore, the pitches in the soprano part between t=0 and t=1 may be reduced to 48 (C), 52 (E), 55 (G), and 60 (C) as shown in FIG.", "23.Similarly, the next harmony note from t=3/2 to t=2 in the soprano part has a key of 0 and a chord of 5.A chord of 5 in the key of 0 (C Major) indicates that pitches that do not lie within the triad of G Major may be discarded.", "As such, the possible pitches for the soprano part from t=3/2 to t=2 are reduced to 50(D), 55(G), and 59(B).", "The bottom (bass) part of the same rhythm sequence of FIG.", "21 between t=0 and t=1 is associated with a key of 0, chord of 1, and is a harmony note.", "The chord indicates that the possible pitches lie within the chord of C Major and the possible bass pitches are updated to 24(C), 28(E), 31(G), and 36(C), illustrated in FIG.", "24.The next bass note from t=1 to t=2 has a key of 0, chord of 5 and is a harmony note.", "Therefore, the possible pitches lie within the chord of G Major and the reduction of the possible pitches is updated to 26(D), 31(G), and 35(B).", "The note in the soprano part between t=1 to t=3/2 is a non-harmony note and may be reduced by analyzing non-harmony information and rules discussed above in the harmony analysis section.", "From the previous discussion, the process of harmony analysis may establish certain criteria for allowed non-harmony movements including the previous scale number in the line, the current scale number in the line, the next scale number in the line, the previous chord, the current chord, the next chord, the previous key, the current key, the next key, and the set of other sounding scalic numbers.", "The above information in the criteria is determined for each of the possible pitches in the non-harmony note (e.g., t=1 to t=3/2 in the soprano part) and is compared with a set of allowed non harmony criteria.", "Each possible pitch that does not match all or at least a portion of the allowed non-harmony criteria may be discarded from the list of possible notes for the non-harmony note.", "For example, from harmony analysis, the following information is derived which can then be used as a guideline to find an acceptable non-harmony pitch in the non-harmony note of the soprano part between t=1 to t=3/2: Previous scale number=1.The current scale number in the line=1.The next scale number in the line=7 (falling from 1).", "The previous chord=1.The current chord=5.The next chord=5.The previous key=0.The current key=0.The next key=0.The set of other sounding scalic numbers=5.In this example, the scale numbers are listed in cyclic form without preserving octave information for ease of the explanation of the core concepts.", "However, actual practice allows for octave information to be preserved within the non harmony structure whilst allowing the structure as whole to be transposed to different octaves.", "For this example, assume that the pitch of the previous scale number (1) is equal to the pitch of the current scale number in the line (1) which is one semitone higher than the next scale number in the line (7) and not any other octave multiple.", "The list of possible pitches for the non-harmony note is examined to determine which of the possible pitches can meet these non harmony criteria.", "It may be determined that the 60(C) note has the following information: Previous scale number=1.The current scale number in the line=1.The next scale number in the line=7.The previous chord=1.The current chord=5.The next chord=5.The previous key=0.The current key=0.The next key=0.The set of other sounding scalic numbers={2,5,7}.", "{2,5,7} contains 5 so this criteria is passed.", "Therefore, 60(C) can be a possible non-harmony pitch.", "However, it may be determined that this is the only pitch that is possible for the rhythm sequence.", "Pitches between 49 and 59 fail as none of these semitones are equal to scalic pitch 1 in C Major (i.e.", "‘C’) Pitch 48 fails on the “next scale number in the line condition” as the current scale number (1) will need to fall one semitone to the next scale number (7).", "However, there is no pitch 47 available in the next harmony note in the rhythm sequence and therefore, this criteria is not met.", "Therefore, in this example, 60(C) is the only possible pitch.", "The possible pitches reduced by chord and harmony reduction are illustrated in FIG.", "25.In this example, the possible non-harmony pitch has been chosen based on the assumptions that the previous scale number was 1, the pitch 60 will fall to the successive 59 in the soprano part, and the simultaneously sounding bass note is scalic pitch 5.In a final reduction, the possible pitches of these related notes may be respectively further reduced to ensure that they do not transgress the non-harmony information listed above.", "The final set of chord and harmony reduced possible pitches is illustrated in FIG.", "26.Movement Pattern Reduction Pitches may have to be limited to fit in line with the newly generated sequence of movement pattern information as described in the part dependent, abstract data generation section.", "This brings into question another remaining theoretical problem which is the balancing of rule transgressions of various components in the recreation stage.", "Accordingly, one or more non-harmony rules may be transgressed in movement pattern reduction.", "It may be the case that after chord and harmony reduction, as in this example, all the soprano pitches would already be definite (finally reduced such that there is only one possible pitch to select for each note), leaving no further notes for movement pattern reduction.", "As such, an alternative embodiment may include the introduction of a higher level, multi-objective balancing that can control the various possible pitch reduction modules to ensure that best combinations of reduction may be chosen at each stage.", "Alternatively, in cases such that the possible pitches are pitchlocked (described in a later section) and can work harmoniously with each other (e.g., when using a pentatonic scale base), chord and harmony pitch reduction may be bypassed.", "For the purposes of describing movement pattern reduction, FIG.", "27 is an alternative visual representation of the rhythm sequence structure in FIG.", "25.The pitches here represent the possible pitches of the notes in their states before the final reduction by the chord and harmony reduction module.", "In this example, suppose an allowed movement pattern from a recorded soprano part is {3,1,2}.", "The movement pattern may specify that he pitch of the first note must be lower than the pitch of the third note which, in turn, must be lower than the pitch of the second note.", "The only possible pitch which currently explicitly transgresses this rule is the 60(C) in the first note between t=0 and t=1, as it is not lower than any possible pitches in the second or third notes.", "Therefore, the 60(C) pitch is removed from the first note of the soprano and the movement pattern reduces the possible pitches for the soprano part, as shown in FIG.", "28.The bass part may consider a recorded movement pattern of {2, 1}.", "The movement pattern specifies that the first note must have a lower pitch than the second note.", "The only pitch that explicitly transgresses this rule is the 36(C) of the first note in the bass part (t=0 to t=1) as there are no possible pitches higher than it in the second note.", "As such, the movement pattern reduced bass possible pitches are illustrated in FIG.", "28.Selecting Pitches After reducing the possible pitches for each note, the movement combination rules described earlier in the horizontal analysis section may be used to guide the decision in choosing these pitches for music composition.", "For each start time of a note or notes, the possible pitches in the relevant notes are analyzed according to the following hierarchy of movement combinations, stopping when one of these combinations is satisfied by the available possible pitches.", "The hierarchy is as follows: Full Scalic Bound Movement Combination Full Semitonal Movement Combination Full Scalic Unbound Movement Combination Part Dependent Single Scalic Bound Movement Combination Part Dependent Single Semitonal Movement Combination Part Dependent Single Scalic Unbound Movement Combination Single Scalic Bound Movement Combination Single Semitonal Movement Combination Single Scalic Unbound Movement Combination Exit Clause 1: Where a pitch is selected randomly from the possible pitches when no suitable movement combination is found.", "Exit Clause 2: Generate a chordal pitch when there are no possible pitches for one or more notes.", "FIG.", "29 presents a diagram of using movement combination information to select pitches from a reduced set of possible pitches in a rhythm structure for using full movement combinations.", "In the exemplary diagram of FIG.", "29, possible pitches in their state of having been reduced by movement pattern rules.", "The arrows in FIG.", "29 represent possible movement combinations resulting from analysis.", "Two note start times, t=1 and t=1.5 are examined in this example.", "At t=1, the first full movement combination dictates that the soprano and bass move upwards in the fashion shown by the arrows from t=0 to t=1.Using this movement combination from the analysis, pitches 55 and 60 may be selected in the soprano part and pitches 24 and 31 may be selected in the bass part on either side of the time divide.", "If the movement combination is full scalic bound, it would dictate a movement from scalic pitch 5 to scalic pitch 1 in the relevant direction in the soprano part and a movement from scalic pitch 1 to scalic pitch 5 in the relevant direction in the bass part.", "If the movement combination is full semitonal, it would dictate a movement of +5 semitones in the soprano part and +7 semitones in the bass part.", "If the movement combination is full scalic unbound, it would dictate a movement of +3 scalic pitches in the soprano part and +4 scalic pitches in the bass part.", "In all of these full movement combinations, the bass pitches would be a definite number of semitones or scalic pitches lower than the pitches in the soprano part.", "If any of these movement combinations are available, then the possible pitches would fit into the rules dictated and allows selection of these pitches on either side of the time divide as definite.", "In the next examined time of t=1.5, the second fun movement combination in the example dictates that the soprano pitch falls as shown and that there is an unmoving held pitch (not just two notes with the same pitch but one note whose length crosses the time divide).", "If a movement combination of this nature is identified from analysis, then the pitches in the soprano part on either side of the t=1.5 time divide may be set as 60(C) and 59(B).", "If the movement combination is full scalic bound, it would dictate a movement from scalic pitch 1 to scalic pitch 7 in the relevant direction of the soprano part and would dictate a held note on scalic pitch=5 at the relevant octave difference.", "If the movement combination is full semitonal, it would dictate a movement of −1 in the soprano part and a held set pitch in the bass part, 29 semitones lower than the soprano pitch of 60(C) at t=1.If the movement combination is full scalic unbound, it would dictate a movement of −1 in the soprano part and a held pitch.", "Again, in all of these full movement combinations, the bass pitches would be a definite number of semitones or scalic pitches lower than the pitches in the soprano part.", "If any of these movement combinations are available, then the possible pitches would fit into the rules dictated and these pitches on either side of the time divide may be selected as definite.", "FIG.", "30 presents a diagram of using movement combination information to select pitches from a reduced set of pitches in a rhythm structure for a series of single movement combinations.", "In this example, the first arrow in the soprano part represents a movement combination that is a part dependent, single movement combination for these possible pitches.", "As such, this movement combination had come from part 1 of 2 in the analysis.", "Again, times t=1 and t=1.5 are examined in this example.", "At t=1, the movement combination in the soprano part dictates that the pitch moves upwards as the first arrow in the soprano part shows.", "If a movement combination of this nature is identified from analysis then pitches 48 and 60 from either side of the time divide for the soprano part may be selected.", "If the movement combination is scalic bound, it would dictate a movement from scalic pitch 1 to scalic pitch 1 with the difference of an octave in an upwards direction.", "If the movement combination is semitonal, it would dictate a movement of +12 semitones.", "If the movement combination is scalic unbound, it would dictate a movement of +7 scalic pitches.", "The movement combination in the bass part dictates a downward pitch movement.", "If a movement combination of this nature is identified from analysis, then the pitches 28 and 26 on either side of the time divide for the bass part may be selected.", "If the movement combination is scalic bound, it would dictate a movement from scalic pitch 3 to scalic pitch 2 with the scalic interval difference of −1 in a downwards direction.", "If the movement combination is semitonal, it would dictate a movement of −2 semitones.", "If the movement combination is scalic unbound, it would dictate a movement of −1 scalic pitches.", "In the next examined time of t=1.5, the movement combination in the soprano part dictates that the pitch moves downwards as the arrow shows.", "If a movement combination of this nature is identified from analysis, then the pitches 60 and 59 from either side of the time divide for the soprano part may be selected.", "If the movement combination is scalic bound, it would dictate a movement from scalic pitch 1−>scalic pitch 7 with the scalic inter al difference of in a downwards direction.", "If the movement combination is semitonal, it would dictate a movement in a downwards direction of −1 semitones.", "If the movement combination is scalic bound, it would dictate a downwards movement of −1 scalic pitches.", "Exit clause 1 may be used when no movement combination is available to guide the part g for a particular time.", "In this case, a random selection from the possible pitches may be made for all notes sounding at this particular time.", "There may also be situations where there are no available possible pitches for a note after pitch reduction (e.g., due to over-aggressive pitch reduction).", "In this situation, exit clause 2 may be employed and a chordal pitch may be generated regardless of whether the note is a harmony note of a non-harmony note.", "The chordal pitch may be determined based on the chord in which the note lies.", "In conjunction with this process, an arbitrary movement combination may also be selected to help guide the music builder to a pitch.", "When all the pitches have been chosen using the above movement combination hierarchy, the resulting notes selected may produce a new music composition.", "Determining Fitness of Composition The movement combination hierarchy listed above may also be used to assess the fitness of the final notes of a new composition.", "The order of hierarchy of the combination movement rules may correspond to the degree of fitness of the new music composition.", "For example, start times with notes whose pitches can be generated by movement combination rules higher up on the hierarchy may generally have higher fitness as they will be more closely related to the style of the original music input piece(s).", "If the pitches of a new composition are entirely dictated by a Full Scalic Bound movement combination, it is highly likely that the part writing would be very similar to the original music input piece(s).", "However, if Exit Clause 1 was used to generate the majority of the pitches of a music composition, it is likely that the part writing of the output piece would be much less similar to that of its music input counterpart(s).", "Another area in which one can measure the fitness of the composition is in the number of transgressions of combination rules that occurred during the creation of sequences of abstract data earlier in the process.", "For example, a chord sequence that is constructed of chord blocks (subsequences) being arranged in a way which gives rise to chords placed adjacently in a manner that was not described in the original input piece(s) is likely to have a lesser fitness than one in which the chord blocks are arranged in such a way that all adjacent chordal movements have been described in original input piece(s).", "Pitch Locking There are some scalic “modes” that are arguably not actually modes in themselves but are rather just a subset of another mode.", "An example of this is the penatatonic scale.", "This can be formed by simply removing some pitches of a major scale.", "To allow for scalic modes such as this, the possible pitches of the population stage are locked or bounded to the scalic mode required.", "For example, the music builder may use only the semitonal or scalic pitches of the music input pieces in the output.", "The music builder may either detect or receive a user selection to operate in a limited scalic mode to limit the pitches available in the population stage to match the limited scale.", "FIGS.", "1 through 30 are conceptual illustrations allowing for an explanation of the present invention.", "It should be understood that various aspects of the embodiments of the present invention could be implemented in hardware, firmware, software, or combinations thereof.", "In such embodiments, the various components and/or steps would be implemented in hardware, firmware, and/or software to perform the functions of the present invention.", "That is, the e piece of hardware, firmware, or module of software could perform one or more of the illustrated blocks (e.g., components or steps).", "In software implementations, computer software (e.g., programs or other instructions) and/or data is stored on a machine readable medium as part of a computer program product, and is loaded into a computer system or other device or machine via a removable storage drive, hard drive, or communications interface.", "Computer programs (also called computer control logic or computer readable program code) are stored in a main and/or secondary memory, and executed by one or more processors (controllers, or the like) to cause the one or ore processors to perform the functions of the invention as described herein.", "In this document, the terms “machine readable medium,” “computer program medium” and “computer usable medium” are used to generally refer to media such as a random access memory (RAM); a read only memory (ROM); a removable storage unit (e.g., a magnetic or optical disc, flash memory device, or the like); a hard disk; or the like.", "Notably, the figures and examples above are not meant to limit the scope of present invention to a single embodiment, as other embodiments are possible by way of interchange of some or all of the described or illustrated elements.", "Moreover, where certain elements of the present invention can be partially or fully implemented using known components, only those portions of such known components that are necessary for an understanding of the present invention are described, and detailed descriptions of other portions of such known components are omitted so as not to obscure the invention.", "In the present specification, an embodiment showing a singular component should not necessarily be limited to other embodiments including a plurality of the same component, and vice-versa, unless explicitly stated otherwise herein.", "Moreover, applicants do not intend for any term in the specification or claims to be ascribed an uncommon or special meaning unless explicitly set forth as such.", "Further, the present invention encompasses present and future known equivalents to the known components referred to herein by way of illustration.", "The foregoing description of the specific embodiments will so fully reveal the general nature of the invention that others can, by applying knowledge within the skill of the relevant art(s) (including the contents of the documents cited and incorporated by reference herein), readily modify and/or adapt for various applications such specific embodiments, without undue experimentation, without departing from the general concept of the present invention.", "Such adaptations and modifications are therefore intended to be within the meaning and range of equivalents of the disclosed embodiments, based on the teaching and guidance presented herein.", "It is to be understood that the phraseology or terminology herein is for the purpose of description and not of limitation, such that the terminology or phraseology of the present specification is to be interpreted by the skilled artisan in light of the teachings and guidance presented herein, in combination with the knowledge of one skilled in the relevant art(s).", "While various embodiments of the present invention have been described above, it should be understood that they have been presented by way of example, and not limitation.", "It would be apparent to one skilled in the relevant art(s) that various changes in form and detail could be made therein without departing from the spirit and scope of the invention.", "Thus, the present invention should not be limited by any of the above-described exemplary embodiments, but should be defined only in accordance with the following claims and their equivalents." ] ]
Patent_15874161
[ [ "IDENTIFYING UNUSED CAPACITY IN WIRELESS NETWORKS", "A method may include determining a capacity metric for sectors in a network, estimating a usage metric for each of the sectors for periods of time and determining a number of user devices that can access data services based on the capacity metric and the usage metric.", "The method may also include storing information identifying the determined number of user devices, receiving a request from a first user device for access to data services during a first period of time and accessing the stored information to determine whether the number of user devices that can access data services for the first period of time is greater than zero.", "The method may further include providing access via the wireless network to the first user device during the first period of time, in response to determining that the number of user devices that can access data services is greater than zero." ], [ "1.A computer-implemented method, comprising: estimating unused data capacity on a wireless network associated with at least on e carrier in each of a plurality of sectors for each of a plurality of periods of time; storing information identifying the estimated unused data capacity for each of the at least one carrier in each of the plurality of sectors for each of the plurality of periods of time; receiving a request from a first user device for access to data services during a first one of the plurality of periods of time, wherein the first user device is associated with a first carrier and a first sector of the plurality of sectors; accessing the stored information to determine whether the unused data capacity via the first carrier in the first sector for the first period of time is available; and providing access to data services via the wireless network to the first user device during the first period of time, in response to determining that the unused data capacity via the first carrier in the first sector for the first period of time is available.", "2.The computer-implemented method of claim 1, wherein the estimating unused data capacity comprises: determining at least one capacity metric for each of the at least one carrier associated with each of the plurality of sectors in the wireless network, estimating at least one usage metric for each of the at least one carrier associated with each of the plurality of sectors for each of the plurality of periods of time, and determining a number of user devices that can access data services via each of the at least one carrier in each of the plurality of sectors for each of the plurality of periods of time, based on the at least one capacity metric and the at least one usage metric.", "3.The computer-implemented method of claim 1, wherein the estimating unused data capacity comprises: determining an active user capacity value identifying a maximum number of user devices that can simultaneously access data services for each of the at least one carrier associated with each of the plurality of sectors in the wireless network, determining an active user usage value identifying an estimated number of active user devices that are expected to simultaneously access data services for each of the at least one carrier associated with each of the plurality of sectors in the wireless network, and determining, based on the active user capacity value and the active user usage value, a number of user devices that can access data services via each of the at least one carrier in each of the plurality of sectors for each of the plurality of periods of time.", "4.The computer-implemented method of claim 1, wherein the storing information identifying the estimated unused data capacity comprises storing the information in a mapping table, the method further comprising: updating the mapping table at predetermined times based on actual usage information for the wireless network; and decrementing, in the mapping table, the unused data capacity for the first carrier in the first sector for a time window corresponding to the first period of time in response to providing access to data services to the first user device during the first period oft e. 5.The computer-implemented method of claim 1, wherein the first user device is associated with a first customer having a data plan, the method further comprising: excluding data usage by the first user device during the first, period of time from being applied against a data limit associated with the data plan.", "6.The computer-implemented method of claim 1, further comprising: receiving a second request from a second user device for access to data services during a second period of time, wherein the second user device is associated with a second carrier in a second sector of the wireless network; accessing the stored information to determine whether the unused data capacity via the second carrier in each of the second sector and at least one sector that is located geographically adjacent to the second sector is available; and providing access to data services to the second user device during the second period of time in response to determining that the unused data capacity via the second carrier in each of the second sector and the at least one geographically adjacent sector for the second period of time is available.", "7.The computer-implemented method of claim 1, further comprising: receiving a second request from a second user device and a third request from a third user device for access to data services during a second period of time, wherein each of the second user device and the third user device is associated with a. second sector in the wireless network; and favoring or providing priority to one of the first user device or the second user device with respect to granting either the second request or the third request based on at least one of power measurements associated with.", "signals received via the'first user device and the second user device or class of service associated with the second request and the third request 8.The computer-implemented method of claim 1, wherein the storing information identifying the estimated unused data capacity comprises: storing information in a mapping table, wherein the mapping table identifies a number of user devices in each of the plurality of sectors, for each of the plurality of periods of tune, that are expected to be available for use based on historical data usage information.", "9.The computer-implemented method of claim 1, further comprising: identifying data usage patterns associated with a second user device, wherein the second user device is associated with a customer of a service provider associated with the wireless network; sending, to the second user device and based on the identified data usage patterns, an offer for unlimited data usage via the wireless network during a second one of the plurality of periods of time; receiving; from the second user device, an acceptance of the offer; and excluding data usage by the second user device during the second period of time from being applied against a data limit associated with a data plan of the customer.", "10.The computer-implemented method of claim 9, further comprising: sending, to the second user device, a message indicating that the second period of time is ending in a predetermined period of time and querying whether a user associated with the second user device would like to continue receiving unlimited data usage for a third period of time.", "11.The computer-implemented method of claim 1, further comprising: providing, to the first user device, an offer for data services for a period of time other than the first period of time, in response to determining that unused data capacity via the first carrier in the first sector for the first period of time is not available.", "12.A system, comprising: a memory; and at least one device configured to: estimate unused data capacity on a wireless network associated with at east one carrier in each of a plurality of sectors for each of a plurality of periods of time, store information identifying the estimated unused data capacity for each of the at least one carrier in each of the plurality of sectors for each of the plurality of periods of time, receive a request from a first user device for access to data services during a first one of the plurality of periods of time, wherein the first user device is associated with a first carrier and a first sector of the plurality of sectors, access the stored information to determine whether the unused data capacity via the first carrier in the first sector for the first period of time is available, and provide access to data services via the wireless network to the first user device during the first period of time, in response to determining that the unused data capacity via the first carrier in the first sector for the first period of time is available.", "13.The system of claim 12, wherein when estimating unused data capacity, the at least one device is configured to: determine at least one capacity metric for each of the at least one carrier associated with each of the plurality of sectors in the wireless network, estimate at least one usage metric for each of the at least one carrier associated with each of the plurality of sectors for each of the plurality of periods of time, and determine a number of user devices that can access data services via each of the at least one carrier in each of the plurality of sectors for each of the plurality of periods of time, based on the at least one capacity metric and the at least one usage metric.", "14.The system of claim 12, wherein when estimating unused data capacity, the at least one device is configured to: determine an active user capacity value identifying a maximum number of user devices that can simultaneously access data services for each of the at least one carrier associated with each of the plurality of sectors in the wireless network, determine an active user usage value identifying an estimated number of active user devices that are expected to simultaneously access data services for each of the at least one carrier associated with each of the plurality of sectors in the wireless network, and determine, based o the active user capacity value and the active user usage value, a number of user devices that can access data services via each of the at least one carrier in each of the plurality of sectors for each of the plurality of periods of time.", "15.The system of claim 12, wherein the first user device is associated with a first customer having a data plan, and wherein the at least one device is further configured to: exclude data usage by the first user device during the first period of time from being applied against a data limit associated with the data plan.", "16.The system of claim 12, wherein the at least one device is further configured to: identify data usage patterns associated'with a second user device, wherein the second user device is associated with a customer of a service provider associated with the wireless network, and send, to the second user device and based on the identified data usage patterns, an offer for unlimited data usage via the wireless network during a second one of the plurality of periods of time.", "17.The system of claim 12, wherein the at least one device is further configured to: provide, to the first user device, an offer for data services for a period of time other than the first period of time, in response to determining that unused data capacity via the first carrier in the first sector for the first period of time is not available.", "18.A non-transitory computer-readable medium having stored thereon sequences of instructions which, when executed by at least one processor, cause the at least one processor to: estimate unused data capacity on a wireless network associated with at least one carrier in each of a plurality of sectors for each of a plurality of periods of time; store information identifying the estimated unused data capacity for each of the at least one carrier in each of the plurality of sectors for each of the plurality of periods of time; receive a request from a first user device for access to data services during a first one of the plurality of periods of time, wherein the first user device is associated with a first carrier and a first sector of the plurality of sectors; access the stored information to determine whether the unused data capacity via the first carrier in the first sector for the first period of time is available; and provide access to data services via the wireless network to the first user device during the first period of time, in response to determining that the unused data capacity via the first carrier in the first sector for the first period of time is available.", "19.The non-transitory computer-readable medium of claim 18, wherein the first user device is associated with a first customer having a data plan, and>wherein the instructions further cause the at least one processor to exclude data usage by the first user device during the first period of time from being applied against a data limit associated with the data plan.", "20.The non-transitory computer-readable medium of 18, wherein the instructions further cause the at least one processor to: identify data usage patterns associated with a second user device, wherein the second user device is associated with a customer of a service provider associated with the wireless network; and send, to the second user device and based on the identified data usage patterns, an offer for unlimited data usage via the wireless network during a second one of the plurality of periods of time." ], [ "<SOH> BACKGROUND INFORMATION <EOH>Wireless broadband network service providers typically provide a customer with a predetermined amount of data usage over a period of time, such as one month, based on the customer's data plan.", "If the customer exceeds the predetermined amount of data usage associated with his/her plan, the service provider will charge the customer a fee for the additional amount of data usage above the plan limit, based on parameters established by the customer's particular data plan.", "Such data service plans typically make a customer cautious in using high bandwidth applications (e.g., data streaming applications) to avoid exceeding his/her data plan limit." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 illustrates an exemplary environment in which systems and methods described herein may be implemented; FIG.", "2 illustrates an exemplary configuration of components implemented in a portion of the network of FIG.", "1 ; FIG.", "3 illustrates an exemplary configuration of logic components included in one or more of the devices of FIG.", "1 ; FIG.", "4 illustrates an exemplary configuration of logic components implemented by one of the devices of FIG.", "1 ; FIG.", "5 illustrates an exemplary configuration of logic components implemented in another one of the devices of FIG.", "1 ; FIG.", "6 is a flow diagram illustrating processing by various components illustrated in FIG.", "1 in accordance with an exemplary implementation; FIG.", "7 illustrates a mapping table generated in accordance with the processing of FIG.", "6 ; FIG.", "8 is a flow diagram associated with requesting data services in accordance with an exemplary implementation; and FIGS.", "9A and 9B illustrate information displayed by the user device of FIG.", "1 in accordance with an exemplary implementation.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "RELATED APPLICATION The present application is a continuation of U.S. application Ser.", "No.", "15/245,910 filed Aug. 24, 2016, the contents of which are hereby incorporated herein by reference in their entirety.", "BACKGROUND INFORMATION Wireless broadband network service providers typically provide a customer with a predetermined amount of data usage over a period of time, such as one month, based on the customer's data plan.", "If the customer exceeds the predetermined amount of data usage associated with his/her plan, the service provider will charge the customer a fee for the additional amount of data usage above the plan limit, based on parameters established by the customer's particular data plan.", "Such data service plans typically make a customer cautious in using high bandwidth applications (e.g., data streaming applications) to avoid exceeding his/her data plan limit.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates an exemplary environment in which systems and methods described herein may be implemented; FIG.", "2 illustrates an exemplary configuration of components implemented in a portion of the network of FIG.", "1; FIG.", "3 illustrates an exemplary configuration of logic components included in one or more of the devices of FIG.", "1; FIG.", "4 illustrates an exemplary configuration of logic components implemented by one of the devices of FIG.", "1; FIG.", "5 illustrates an exemplary configuration of logic components implemented in another one of the devices of FIG.", "1; FIG.", "6 is a flow diagram illustrating processing by various components illustrated in FIG.", "1 in accordance with an exemplary implementation; FIG.", "7 illustrates a mapping table generated in accordance with the processing of FIG.", "6; FIG.", "8 is a flow diagram associated with requesting data services in accordance with an exemplary implementation; and FIGS.", "9A and 9B illustrate information displayed by the user device of FIG.", "1 in accordance with an exemplary implementation.", "DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS The following detailed description refers to the accompanying drawings.", "The same reference numbers in different drawings may identify the same or similar elements.", "Also, the following detailed description does not limit the invention.", "Implementations described herein relate to estimating network utilization during various periods of time based on historic and/or expected network usage.", "In one exemplary implementation, a service provider dynamically estimates future network usage and determines an expected excess network capacity during various future periods of time.", "The service provider may determine the expected excess network capacity on a per sector, cell or other level.", "The service provider may then offer slots of time for using the wireless service when excess network capacity is expected to exist.", "For example, the service provider may offer a certain number of users access to data service during time slots that otherwise would be unused.", "In some instances, the service provider may offer unlimited data access during the time slots that are available for free as a part of a bundled plan or for a per-slot charge, with the data usage during these time slots not counting against the customer's monthly plan limit.", "When customers use the wireless service during time slots that would otherwise be unused, overall network utilization increases as a result of the increase in efficiency of the resource usage.", "For example, use of cell capacity and network capacity may be increased resulting in optimized cell and network capacity and bandwidth usage.", "In addition, having a more fully loaded or utilized network allows the service provider to more accurately determine full network capacity under actual conditions.", "For example, loading the network to full or near full capacity by using otherwise unused time slots may allow the service provider to determine how much data capacity/load the wireless network can actually handle, as opposed to a theoretical maximum load.", "In addition, monitoring the wireless network under fully or nearly fully loaded conditions may allow the service provider to identify locations where additional network resources are needed to ensure and/or improve network availability and reliability.", "FIG.", "1 is a block diagram of an exemplary environment 100 in which systems and methods described herein may be implemented.", "Environment 100 may include user devices 110-1 through 110-N, network support system (NSS) 120, service provider 130 and network 150.User devices 110-1 through 110-N (individually referred to as user device 110-x or 110 and collectively as user devices 110) may include a mobile device, such as wireless or cellular telephone device (e.g., a conventional cell phone with data processing capabilities), a smart phone, a personal digital assistant (PDA) that can include a radiotelephone, etc.", "In another implementation, user devices 110 may include any type of mobile computer device or system, such as a personal computer (PC), a laptop, a tablet computer, a notebook, a netbook, a wearable computer (e.g., a wrist watch, eyeglasses, etc.", "), a game playing device, a music playing device, a home appliance device, a home monitoring device, etc., that may include communication functionality.", "User devices 110 may connect to network 150 and other devices in environment 100 (e.g., NSS 120, service provider 130, etc.)", "via any conventional technique, such as wired, wireless, optical connections or a combination of these techniques.", "User device 110 and the person associated with user device 110 (e.g., the party holding or using user device 110) may be referred to collectively as user device 110 in the description below.", "NSS 120 may include one or more computing devices or systems used to estimate utilization of network 150.For example, NSS 120 may communicate with base stations, eNodeBs, gateways, specialized data monitoring devices, etc., to determine loading conditions on network 150.NSS 120 may also access historical data usage associated with network 150 during various times of day to estimate future network load conditions, such as whether excess capacity will be available during various time periods, as described in more detail below.", "Service provider 130 may include one or more computer devices and systems associated with providing wireless services via network 150.For example, service provider 130 may store information regarding service plans for a large number of subscribers (also referred to herein as customers) and track data usage for each subscriber over a period of time (e.g., one month).", "Service provider 130 may communicate with NSS 120 to identify future time periods that may be offered to subscribers for data service, as described in more detail below.", "Network 150 may include one or more wired, wireless and/or optical networks that are capable of receiving and transmitting data, voice and/or video signals.", "For example, network 150 may include one or more public switched telephone networks (PSTNs) or other type of switched network.", "Network 150 may also include one or more wireless networks and may include a number of transmission towers for receiving wireless signals and forwarding the wireless signals toward the intended destinations.", "Network 150 may further include one or more satellite networks, one or more packet switched networks, such as an Internet protocol (IP) based network, a local area network (LAN), a wide area network (WAN), a personal area network (PAN), a long term evolution (LTE) network, a WiFi network, a Bluetooth network, an intranet, the Internet, or another type of network that is capable of transmitting data.", "Network 150 provides wireless packet-switched services and wireless Internet protocol (IP) connectivity to user devices 110 to provide, for example, data, voice, and/or multimedia services.", "The exemplary configuration illustrated in FIG.", "1 is provided for simplicity.", "It should be understood that a typical network may include more or fewer devices than illustrated in FIG.", "1.For example, environment 100 may include a large number (e.g., thousands or more) of user devices 110 and multiple NSSs 120.In addition, network 150 may include additional elements, such as eNodeBs, base stations, switches, gateways, routers, monitoring devices, etc., that aid in routing data and collecting information regarding network conditions.", "In addition, various functions are described below as being performed by particular components in environment 100.In other implementations, various functions described as being performed by one device may be performed by another device or multiple other devices, and/or various functions described as being performed by multiple devices may be combined and performed by a single device.", "FIG.", "2 is an exemplary block diagram illustrating a portion of network 150.In the implementation depicted in FIG.", "2, network 150 is a long term evolution (LTE) network.", "It should be understood, however, that embodiments described herein may operate in other types of wireless networks, such as networks operating with other networking standards, such Global System for Mobile Communications (GSM), Universal Mobile Telecommunications System (UMTS), IS-2000, etc.", "Network 150 may include an evolved packet core (ePC) that includes an evolved Node B (eNodeB) 220, mobile management entity (MME) 230, serving gateway (SGW) 240, packet gateway (PGW) 250, home subscriber server (HSS) 260 and policy and charging rules function (PCRF) 270.EnodeB 220 may be part of an evolved Universal Mobile Telecommunications System (UMTS) Terrestrial Radio Access Network (eUTRAN).", "eNodeB 220 may include one or more devices and other components having functionality that allow user devices 110 to wirelessly connect to network 150.eNodeB 220 may be associated with one or more cells/sectors.", "For example, each cell or sector in network 150 may include one or more radio frequency (RF) transceivers pointed in a particular direction.", "In one implementation, some of the eNodeBs 220 may be associated with multiple sectors (e.g., 2, 3 or more) of network 150.In such an implementation, an eNodeB 220 may include multiple RF transceivers pointed in different directions to service different geographic areas.", "The term “sector” as used herein shall be broadly construed as any geographic area associated with an eNodeB, base station or other element of a radio network, and may be used interchangeably with the term “cell.” Each sector in network 150 may also be associated with multiple carriers.", "For example, an eNodeB 220 may include multiple radios that operate at different frequencies or different frequency bands in the same sector.", "eNodeB 220 may interface with MME 230.MME 230 may include one or more devices that implement control plane processing for network 150.For example, MME 230 may implement tracking and paging procedures for user devices 110, may activate and deactivate bearers for user devices 110, may authenticate respective users of user devices 110, and may interface with non-LTE radio access networks.", "A bearer may represent a logical channel with particular quality of service (QoS) requirements, and can be used in some embodiments to control packet flows as described herein.", "MME 230 may also select a particular SGW 240 for a particular user device 110.MME 230 may interface with other MME devices (not shown) in network 150 and may send and receive information associated with user devices 110, which may allow one MME 230 to take over control plane processing of user devices 110 serviced by another MME 230, if the other MME 230 becomes unavailable.", "SGW 240 may provide an access point to and from user devices 110, may handle forwarding of data packets for user devices 110, and may act as a local anchor point during handover procedures between eNodeBs 220.SGW 240 may interface with PGW 250.PGW 250 may function as a gateway to a core network, such as a wide area network (WAN) (not shown) that allows delivery of Internet protocol (IP) services to user devices 110.HSS 260 may store information associated with user devices 110 and/or information associated with users of user devices 110.For example, HSS 260 may store user profiles that include authentication and access authorization information.", "Each user/subscription profile may include a list of user devices 110 associated with the subscriptions as well as an indication of which user devices 110 are active (e.g., authorized to connect to network 150).", "PCRF 270 may implement policy charging and rule functions, such as providing quality of service (QoS) requirements, bandwidth and/or charges for a particular service for user devices 110.PCRF 270 may determine how a certain service data flow will be treated, and may ensure that user plane traffic mapping and treatment is in accordance with a user's subscription profile.", "Although FIG.", "2 shows exemplary components of network 150, in other implementations, network 150 may include fewer components, different components, differently arranged components, or additional components than depicted in FIG.", "2.For example, network 150 may include a large number of eNodeBs 220, MMES 230, SGWs 240, PGWs 250 HSSs 260 and PCRFs 270.Additionally, or alternatively, one or more components of network 150 may perform functions described as being performed by one or more other components.", "FIG.", "3 illustrates an exemplary configuration of NSS 120.Other devices in environment 100, such as user device 110 and service provider 130 may be configured in a similar manner.", "Referring to FIG.", "3, NSS 120 may include bus 310, processor 320, memory 330, input device 340, output device 350 and communication interface 360.Bus 310 may include a path that permits communication among the elements of NSS 120.Processor 320 may include one or more processors, microprocessors, or processing logic that may interpret and execute instructions.", "Memory 330 may include a random access memory (RAM) or another type of dynamic storage device that may store information and instructions for execution by processor 320.Memory 330 may also include a read only memory (ROM) device or another type of static storage device that may store static information and instructions for use by processor 320.Memory 330 may further include a solid state drive (SDD).", "Memory 330 may also include a magnetic and/or optical recording medium (e.g., a hard disk) and its corresponding drive.", "Input device 340 may include a mechanism that permits a user to input information to NSS 120, such as a keyboard, a keypad, a mouse, a pen, a microphone, a touch screen, voice recognition and/or biometric mechanisms, etc.", "Output device 350 may include a mechanism that outputs information to the user, including a display (e.g., a liquid crystal display (LCD)), a printer, a speaker, etc.", "In some implementations, a touch screen display may act as both an input device and an output device.", "Communication interface 360 may include one or more transceivers that NSS 120 (or user device 110 or service provider 130) uses to communicate with other devices via wired, wireless or optical mechanisms.", "For example, communication interface 360 may include one or more radio frequency (RF) transmitters, receivers and/or transceivers and one or more antennas for transmitting and receiving RF data via network 150.Communication interface 360 may also include a modem or an Ethernet interface to a LAN or other mechanisms for communicating with elements in a network, such as network 150 or another network.", "The exemplary configuration illustrated in FIG.", "3 is provided for simplicity.", "It should be understood that NSS 120 (or user device 110 or service provider 130) may include more or fewer devices than illustrated in FIG.", "3.In an exemplary implementation, NSS 120 (or user device 110 or service provider 130) perform operations in response to processor 320 executing sequences of instructions contained in a computer-readable medium, such as memory 330.A computer-readable medium may be defined as a physical or logical memory device.", "The software instructions may be read into memory 330 from another computer-readable medium (e.g., a hard disk drive (HDD), SSD, etc.", "), or from another device via communication interface 360.Alternatively, hard-wired circuitry may be used in place of or in combination with software instructions to implement processes consistent with the implementations described herein.", "Thus, implementations described herein are not limited to any specific combination of hardware circuitry and software.", "FIG.", "4 is an exemplary functional block diagram of components implemented in NSS 120.In an exemplary implementation, all or some of the components illustrated in FIG.", "4 may be implemented by processor 320 executing software instructions stored in memory 330.NSS 120 may include network monitoring logic 410, data capacity logic 420, database 430, time slot management logic 440 and communication logic 450.In alternative implementations, these components or a portion of these components may be located externally with respect to NSS 120.Network monitoring logic 410 may include logic to identify data usage on network 150 during actual loading conditions in real time or near real time.", "In one implementation, network monitoring logic 410 may communicate with various gateways, eNodeBs and network monitoring devices located throughout network 150 to identify data usage on network 150.In addition, network monitoring logic 410 may identify total data traffic on a per sector basis.", "For example, network monitoring logic 410 may gather radio performance measurements from each sector site in network 150 over various periods of time.", "Network monitoring logic 410 may store this information in database 430.Data capacity logic 420 may include logic to identify the capacity of each sector in network 150.In some instances, the capacity may vary over time.", "For example, based on addition of new equipment in a particular cell, the capacity may increase.", "Alternatively, if equipment is being serviced in a particular sector, the network capacity for that cell may decrease.", "The data capacity for a particular sector may also incorporate various metrics, such as cell bandwidth, spectral efficiency, propagation characteristics, etc.", "Data capacity logic 420 may store current capacity information in database 430.Database 430 may includes one or more data storage devices that store one or more databases of information associated with network 150.For example, as described above, network monitoring logic 410 may store data usage information on a per sector level granularity in database 430.In addition, data capacity logic 420 may store data capacity information for network 150 on a per sector level granularity in database 430.Time slot management logic 440 may include logic to determine the current or expected unused capacity of network 150 on a per sector basis at any given time or over a period of time.", "For example, time slot management logic 440 may estimate an amount of data capacity in each sector that is expected to be unused for each of a number of different future periods of times (also referred to herein as time slots).", "Time slot management logic 440 may determine if excess data capacity can and should be provisioned or offered to various customers, as described in more detail below.", "Communication logic 450 may include logic to communicate with elements in environment 100 directly or via network 150.For example, communication logic 450 may provide alerts to customers or subscribers associated with service provider 130.For example, communication logic 450 may signal customers that time slots for data usage (e.g., streaming downloads) are available at particular periods of the time, as described in more detail below.", "Communication logic 450 may also provide information to service provider 130 regarding customers' usage of data.", "Although FIG.", "4 shows exemplary components of NSS 120, in other implementations, NSS 120 may include fewer components, different components, differently arranged components, or additional components than depicted in FIG.", "4.In addition, functions described as being performed by one of the components in FIG.", "4 may alternatively be performed by another one or more of the components of NSS 120.FIG.", "5 is an exemplary functional block diagram of components implemented in user device 110 of FIG.", "1.Referring to FIG.", "5, wireless data program 500 and its various logic components are shown in FIG.", "5 as being included in user device 110.For example, wireless data program 500 may be stored in memory 330 of user device 110.In alternative implementations, these components or a portion of these components may be located externally with respect to user device 110.Wireless data program 500 may be an application program associated with the user's data plan provided by service provider 130.Wireless data program 500 may include software instructions executed by processor 320 that allows a user associated with user device 110 to request data usage during particular periods of time, or receive alerts from NSS 120 and/or service provider 130 indicating that “unlimited” data is available during particular periods of time.", "In some implementations, service provider 130 may not track or count the additional data usage against the user's data plan limits and may allow for unlimited data usage during particular periods of time, as described in more detail below.", "Wireless data program 500 may include user interface logic 510, communication logic 520 and display logic 530.User interface logic 510 may include logic to facilitate requesting or accepting use of data services via network 150.For example, user interface logic 510 may include a graphical user interface (GUI) that allows a user to input information requesting or accepting a particular time slot for network access and use.", "In addition, the GUI of user interface logic 510 may allow a user to input information responding to an offer for data usage, as described in detail below.", "Communication logic 520 may include logic for communicating with other devices in environment 100.For example, communication logic 520 may transmit and/or receive information from NSS 120 and service provider 130 via network 150.As an example, communication logic 520 may allow user device 110 to request use of an available time slot for a data streaming session.", "As another example, communication logic 520 may allow user device 110 to receive offers from NSS 120 and/or service provider 130 regarding use of excess network capacity.", "Display logic 530 may include logic to display information received from, for example, NSS 120 and service provider 130.In one exemplary implementation, display logic 530 may output information to output device 350 of user device 110, such as an LCD or another type of display.", "As an example, display logic 530 may display a message from NSS 120 or service provider 130 indicating that unlimited data usage is available for a current or future time period.", "In some implementations, display logic 530 may also display how much time is remaining in a current unlimited data usage session, as described in more detail below.", "FIG.", "6 is a flow diagram illustrating exemplary processing associated with determining available excess capacity in a wireless network, such as network 150.Processing may begin with NSS 120 estimating data volume (DV) capacity for sectors in network 150 (block 610).", "For example, data capacity logic 420 may determine the capacity of each sector in network 150 in megabytes per hour (MB/hour), megabits per second (Mb/s) or some other value.", "In some implementations, as described above, some of the eNodeBs 220 in network 150 may include multiple RF carriers per sector.", "In such implementations, data capacity logic 420 may determine the capacity for each carrier in each sector (referred to herein as a sector carrier).", "In addition, when estimating DV capacity in network 150, data capacity logic 420 may take into consideration underlying metrics associated with network 150, such as cell bandwidth, spectral efficiency, data propagation characteristics, etc.", "Data capacity logic 420 may store this information in database 430 (block 610).", "NSS 120 may also estimate DV usage for each sector (block 620).", "For example, network monitoring logic 410 may estimate DV usage based on the actual usage of each sector and/or sector carrier in each sector over a predetermined number of time periods.", "In one implementation, network monitoring logic 410 may calculate DV usage as a percentage (e.g., 85%) of the actual usage on each sector carrier over the last N number of days in 15 minute time aggregation intervals, wherein N is any integer number (e.g., 1 day, 5 days, 7 days, etc.).", "It should also be understood that other time intervals may be used (e.g., 30 minute intervals, 60 minute intervals, etc.).", "In each case, network monitoring logic 410 estimates DV usage to capture local demand profile information for relatively short time intervals.", "Different systems may use different values for the aggregation intervals.", "Network monitoring logic 410 may store this information in database 430 (block 620).", "NSS 120 may also calculate data throughput (TP) for each sector (block 630).", "For example, network monitoring logic 410 may calculate data TP for each sector carrier in each sector over each selected time interval (e.g., 15 minute intervals).", "Calculating TP accounts for typical cell load that is observed in the particular sector carrier in the particular time interval.", "In some implementations, target throughput may also be estimated based on usage for different types of data, such as a high definition (HD) video stream.", "The target TP may be useful when the available capacity on a sector exceeds what is required to support applications, such as HD video streaming.", "NSS 120 may further estimate active user (AU) capacity for each sector (block 640).", "For example, data capacity logic 420 may determine the number of users that can be active for each sector carrier of network 150 during each selected period of time, also referred to herein as transmission time interval (TTI) or time window.", "When estimating AU capacity in network 150, data capacity logic 420 may take into consideration underlying metrics associated with network 150, such as cell bandwidth, spectral efficiency, data propagation characteristics, etc.", "NSS 120 may also calculate an average active user usage (AUUsg) value for each sector (block 640).", "For example, network monitoring logic 410 may estimate the average active user usage based on a percentage of the actual usage of each sector carrier over the last N days in each T minute time window.", "In one implementation, network monitoring logic 410 may estimate the average active user usage as about 85% of the actual active user usage for each sector carrier over the last N days in each T minute time window.", "Estimation of active user usage captures usage profile and demand that is observed in the particular sector carrier in the particular time interval.", "In alternative implementations, other percentages may be used (e.g., average plus one standard deviation, average plus two standard deviations, etc.).", "NSS 120 may then calculate the number of additional user devices that can be supported in each sector in each time window (block 650).", "For example, the additional number of user devices Z, where Z is an integer value, may correspond to the number of user devices that can access a particular sector/carrier above the number of user devices that are expected to use that sector/carrier in network 150 during a particular period of time.", "In other words, the number Z may correspond to additional time slots of data usage that are expected to be unused based on historical data usage.", "In one implementation, time slot management logic 440 may calculate Z using equation 1 below.", "Z=Max [0, Floor (MIN ((DV capacity−DV usage)/(C*TP), AUl capacity−AU usage))] Equation 1 That is, time slot management logic 440 may calculate a number of users Z that can be supported by each sector carrier as the maximum of zero and a variable “Floor” in equation 1, corresponding to the minimum of the value calculated by subtracting DV usage from DV capacity and dividing the result by a constant “C” multiplied by the throughput (TP), and the value calculated by subtracting AU usage from AU capacity.", "In one implementation, the constant C in equation 1 is a value associated with converting Megabits per second into Megabytes per hours and is equal to the value 450.For example, C in equation 1 (which is multiplied by TP in the denominator of the first value from which the minimum value (i.e., NIN) is selected) may correspond to converting Megabits/second into Megabytes/hour and in one implementation is equal to 3600 seconds/hour divided by 8 bits/byte, which is equal to 450.Time slot management logic 440 may then take the maximum of zero and the minimum of the two values calculated for the variable “Floor” in equation 1.Time slot management logic 440 may repeat this calculation for each sector carrier for each period of time.", "NSS 120 uses the calculated Z values to populate a mapping table that identifies the number of slots for each interval of time that are available for use in each sector (block 660).", "FIG.", "7 illustrates mapping table 700, which includes eNodeB field 710, sector field 720, carrier field 730 and time window field 740.Mapping table 700 may be stored in database 430.eNodeB field 710 identifies various eNodeBs 220 in network 150.Sector field 720 identifies various sectors served by the corresponding eNodeBs 220.Each eNodeB 220 may service more than one sector (e.g., three or more sectors) in network 150, as illustrated in FIG.", "7.For example eNodeB 210001 services the sectors, designated as sectors 1, 2 and 3.Carrier field 730 identifies a particular RF carrier associated with an eNodeB 220.For example, as described above, each eNodeB 220 may include multiple radios that operate at different frequencies or different frequency bands within the same sector.", "For example, eNodeB 210002 in sector 1 includes two sector carriers, designated as carriers 1 and 2.Time window field 740 (also referred to herein as time slots field 740) includes a number of 15 minute intervals of time throughout the day (a portion of which are illustrated in table 700).", "The values in the entries in time window field 740 correspond to the Z values calculated in accordance with Equation 1 above, and identify the number of available time slots which are expected to be unused and available for customers' use within each time window 740.For example, in entry 702-1, which corresponds to eNodeB 210001, sector 1, carrier 1, there is one time window available for the time period 1:00-1:15, three time windows available for the time period 1:15-1:30, five time windows available for the time period 1:30-1:45, etc., as indicated in time window field 740 for entry 702-1.Time slots granted to user devices 110 may encompass multiple consecutive time windows, subject to availability in successive time windows.", "Service provider 130 may make the identified time slots available to customers.", "For example, in one implementation, customers may request time slots via wireless data program 500.In some instances, a user may request a time slot and NSS 120 may process the request on a first come, first served basis.", "In other instances, NSS 120 and/or service provider 130 may advertise the availability of the time slots to customers based on the customers' historic usage patterns and/or geographic locations.", "For example, NSS 120 and/or service provider 130 may access historic data usage indicating that a particular customer uses large amounts of data at a particular location and/or at a particular time of day (e.g., at home between 8:00 PM and 9:00 PM).", "In this case, NSS 120 may send an offer to user device 110 associated with that particular customer indicating that unlimited data usage is available for that period of time at that particular customer's geographic location.", "As described above, in some implementations, data usage during the time slots illustrated in mapping table 700 may correspond to an unlimited amount of data usage during that period of time.", "In addition, service provider 130 may not count or track usage corresponding to the requested time slots against the customers' data plan limits.", "For example, in one implementation, if a customer associated with user device 110-1 requests a time slot serviced by eNodeB, sector 1 at 1:15-1:30 and NSS 120 grants the request, service provider 130 will not count data usage during this time slot against the customer's monthly allotment.", "In some instances, service provider 130 may make an offer to the customer for the unlimited data usage during the time slot.", "In some instances, service provider 130 may charge the customer a relatively low fee for the unlimited data usage during the requested time slot (e.g., $1 or less for a one hour data session).", "In another instance, service provider 130 may offer the customer an option to view or evaluate certain content in exchange for the unlimited data usage during the requested time slot.", "This allows service provider 130 to more fully and efficiently utilize network capacity.", "As a result, overall network utilization increases.", "In addition, having a more fully loaded or utilized network allows service provider 130 to more accurately determine full network capacity under actual conditions, as opposed to a theoretical maximum capacity.", "In addition, monitoring network 150 under fully or nearly fully loaded conditions may allow service provider 130 to identify locations where additional network resources (e.g., eNodeBs, gateways, routers, etc.,) are needed to ensure or increase network availability and reliability.", "NSS 120 may refresh mapping table at predetermined periods of time (block 670).", "For example, NSS 120 may update mapping table daily, weekly, monthly, etc.", "In each case, mapping table 700 stores information identifying time periods in which excess network capacity is expected to exist.", "In addition, mapping table 700 may be regenerated to account for updated historical usage information.", "However, the refreshing or updating of mapping table 700 may exclude traffic volume changes associated with usage attributed to excess capacity in the time slots associated with mapping table 700 during the previous period of time.", "FIG.", "8 is a flow diagram illustrating processing associated with requesting time slots in network 150.Processing may begin with a user associated with user device 110 launching or accessing wireless data program 500.The user of user device 110 may then provide input requesting a time slot of a certain duration beginning at a certain time (block 810).", "For example, the user, via a GUI provided by user interface logic 510, may request a particular time slot for streaming data (e.g., watch a live sporting event, download a movie, listen to music, etc.).", "Communication logic 520 may forward the request to NSS 120.The request from user device 110 may include a cell ID identifying the cell to which user device 110 is currently connected.", "The request from user device 110 may also include the duration of the request (e.g., 30 minutes, 40 minutes, etc.).", "In alternative implementations, after wireless data program 500 is launched, communication logic 520 may signal NSS 120 requesting information identifying available time slots for accessing network 150.In response, communication logic 450 of NSS 120 may forward information to user device 110 indicating the available time slots.", "Assume that user device 110 has transmitted a request for a time slot of a certain duration to NSS 120.NSS 120 receives the request and may store the request in a first in, first out (FIFO) queue for incoming requests.", "NSS 120 may pull each request from the FIFO queue in sequence and process the request.", "NSS 120 may identify cell information from the request, such as the cell/sector identifier (ID) and a sector carrier on which the request was received, and also identify the duration of the request (block 820).", "NSS 120 then queries table 700 using the sector ID, sector carrier and the duration of the request to determine if the requested time slot duration is available (block 830).", "That is, NSS 120 compares the requested duration to the maximum consecutive 15 minutes slots that are available in the particular sector and carrier.", "If an adequate number of time slots in the appropriate sector with the appropriate carrier are available to fulfill the request, NSS 120 provisions the time slot to user device 110 (block 840).", "For example, assume that a user device 110 attached to eNodeB 210002, sector 1 and communicating via sector carrier 2, requests a 45 minutes time slot at 1:05.Referring to table 700, time window field 740 for time period 1:30-1:45 in entry 702-5 indicates that zero time slots are available from 1:30-1:45 (i.e., no time slot is available).", "In some implementations, NSS 120 may grant user device 110 a partial time slot, such as a time slot from only 1:05-1:30, since no time slots are available from 1:30-1:45 (block 850).", "In other implementations, if the full time period is not available (block 830—no), time slot management logic 440 may identify an alternative time slot in which the full time period is available (block 850).", "For example, time slot management logic 440 may identify time slots from 1:45 through 2:30 as being available since each of those time periods has values greater than zero.", "Time slot management logic 440 may offer those time slots to the user.", "In other implementations, NSS 120 may signal user device 110 that the requested time slot is not available.", "Assume that the time slot, a partial time slot or an alternative time slot was granted to user device 110.NSS 120 may send user device 110 a message indicating that the time slot has been granted for unlimited data usage during the granted time slot.", "User device 110 may receive the message from NSS 120 and display logic 530 of wireless data program 500 may output the message.", "For example, referring to FIG.", "9A, user device 110, corresponding to a smart phone device in this example, may display message 910 via an output screen of user device 110.The message may indicate “unlimited data session available for 25 minutes,” as illustrated in FIG.", "9A.", "In this scenario, after provisioning the 1:05-1:30 time slot, NSS 120 subtracts one time slot from each of the entries for the 1:00-1:15 time window and the 1:15-1:30 time window in entry 702-5 shown in mapping table 700 to ensure that mapping table 700 includes an accurate count of available time slots.", "As another example, assume that a user attached to eNodeB 210055, sector 3 via carrier 1 requests a 30 minute time slot at 1:30.NSS 120 checks table 700 and determines that time slots in entry 702-12 (corresponding to eNodeB 210055, sector 3, carrier 1) are available from 1:30 through 2:30.In this case, NSS 120 may offer additional time slots beyond the requested 30 minute time slot at an incremental cost.", "For example, NSS 120 may provision the 30 minute time slot from 1:30-2:00 and offer the user the time slot between 2:00 and 2:30 for an additional small fee or in exchange for the customer agreeing to receive content from service provider 130.In either case, when NSS 120 provisions the 30 minute time slot, time slot management logic 440 subtracts one from each appropriate time slot (i.e., time slot 1:30-1:45 and 1:45-2:00) in entry 702-12.If, however, the user chooses the additional 30 minute time slot (i.e., from 2:00-2:30), time slot management logic 440 subtracts one from each additional time slot (i.e., 2:00-2:15 and 2:15-2:30) in entry 702-12.In some implementations, NSS 120 may identify that a time slot associated with a granted user session is coming to an end (block 860).", "In this case, NSS 120 may send a message to user device 110 indicating that a current session is coming to an end (block 860).", "For example, in some instances NSS 120 may send a message to user device 110 a short period of time (e.g., 5 minutes) prior to the ending of a data session.", "User device 110 may receive the message and output the message to the user, as illustrated in FIG.", "9B.", "Referring to FIG.", "9B, user device 110 may display message 920 indicating that “unlimited data session is ending in 5 minutes,” and query whether the user would like to continue the unlimited data session.", "For example, the message may be “do you want to continue the unlimited data session for another 30 minutes?” In this manner, NSS 120 may provide the user with additional opportunities to access unlimited data usage via network 150.As described above, NSS 120 may provision requests from user devices 110 on a first come, first served in basis.", "In other implementations, NSS 120 may account for user mobility in granting slots.", "For example, in some implementations, NSS 120 may check mapping table 700 for the availability of time slots in the sector to which a user device is currently attached and to sectors within a predetermined radius (e.g., 5 miles, 10 miles, 30 miles, etc.)", "of the user's current sector.", "That is, NSS 120 may check mapping table for available time slots within a distance or radius of the current sector in case the user moves to a new location outside the original sector.", "In this case, NSS 120 checks for availability in geographically adjacent sectors within the predetermined distance or radius.", "In some implementations, NSS 120 may make sure that time slots are available in the geographically adjacent sectors prior to determining whether to grant a customer's request for an unlimited data session.", "In some implementations, NSS 120 may also check whether time slots associated with particular carrier frequencies are available in neighboring sectors prior to granting a time slot.", "This also accounts for user mobility over time.", "Still further, in some implementations, features such as carrier aggregation may be disabled when accessing available time slots.", "For example, carrier aggregation may aggregate multiple bands on a user device 110 simultaneously, such that a user device 110 can use, for example, a 700 Megahertz (MHz) band and another advanced wireless services (AWS) band simultaneously for downloads.", "In this case, granting time slots to such a user device 110 may have more impact on network 150 than if carrier aggregation is not used.", "To mitigate such impact, carrier aggregation may be turned off/disabled when accessing time slots identified in mapping table 700.In another alternative implementation, if a device is known to be carrier aggregation capable, then the number of slots for both carriers can be reduced by one when a request/session is granted.", "In addition, in some implementations, NSS 120 and/or service provider 130 may account for time and/or location restrictions in allotting time slots via mapping table 700.For example, NSS 120 may exclude certain areas in a city (e.g., a busy downtown business district) during working hours (e.g., 9:00 AM to 5:00 PM), or a sports stadium during a sporting event from mapping table 700.That is, time slot management logic 440 may reduce the number of available time slots (e.g., to a small number or zero) in an area that is expected to be crowded with user devices 110 that are expected to fully load network 150 during those time periods.", "Advance information from various systems, such as sports/concert ticketing systems, provided through application programming interfaces (APIs) may be used to determine the expected number of users at a particular location during a period of time.", "As described above, time slot management logic 440 may process requests from user devices 110 on a first come, first served basis.", "In other implementations, NSS 120 may grant time slots to user devices that would cause less impact on overall processing throughput.", "For example, NSS 120 may make radio frequency (RF) power measurements, such as received signal received power (RSRP) measurements, to determine an approximate location of user device 110 based on the RSRP associated with a request.", "In this case, time slot management logic 440 may favor a user device 110 that has a greater RSRP value, indicating that the user is closer to the center of the sector.", "As a result, such a user is expected to have less impact on spectrum resources per megabyte volume than a user located on an edge portion or outer area of a sector.", "In this implementation, NSS 120 gives preferences to user device 110 that has less impact on overall network efficiency.", "In addition, in some implementations, network 150 may support multiple scheduler classes of service.", "That is, traffic can be assigned to different quality of service (QoS) classes.", "In this case, NSS 120 may favor classes of service that will have less impact on network 150, thereby mitigating impact on other types of expected traffic.", "Implementations described herein provide for estimating unused capacity on a network.", "The unused capacity may then be offered to customers during relatively short intervals of time.", "In some instances, the unused capacity may be offered as unlimited data usage over the granted periods of time and the amount of data usage during these time periods will not count against a customer's monthly data plan allotment.", "In some instances, the “extra” data usage will be charged to the customer at a relatively low rate, as compared to the customer's charges for data usage via the customer's regular data plan.", "In other instances, the extra data may be provided in exchange for the user agreeing to receive, view and/or rank content provided by the service provider or another third party.", "The foregoing description of exemplary implementations provides illustration and description, but is not intended to be exhaustive or to limit the embodiments to the precise form disclosed.", "Modifications and variations are possible in light of the above teachings or may be acquired from practice of the embodiments.", "For example, features have been described above with respect to estimating a capacity metric and a usage metric to identify the number of available time slots.", "In other implementations, other metrics that account for the number of connections on an eNodeB, the physical resource block utilization (PRBU) or the transmission time interval utilization (TTIU) may be used to identify available unused capacity.", "In each case, historical data usage and estimated capacity may be used to estimate unused capacity for future periods of time.", "The unused capacity may then be offered to customers, resulting in a more fully loaded network.", "In addition, offering unused to capacity to customers for unlimited usage during various periods of time may increase the utilization of network 150 during traditionally off-peak hours.", "This off-peak usage may result in a less congested network during typical peak times, thereby resulting in increased data throughput on network 150 and increased customer satisfaction.", "In addition, implementations described above refer to estimating data capacity associated with eNodeBs that support multiple sectors and multiple sector carriers.", "It should be understood that implementations described herein can be used with a network in which eNodeBs or cell sites support one sector and/or one carrier.", "Still further, implementations have been described herein as measuring data capacity and usage on a sector carrier level granularity.", "In other implementations, data capacity and usage could be measured/estimated on a higher or lower granularity (e.g., a sector level, a sub-carrier level, etc.).", "Further, while series of acts have been described with respect to FIGS.", "6 and 8, the order of the acts may be different in other implementations.", "Moreover, non-dependent acts may be implemented in parallel.", "It will be apparent that various features described above may be implemented in many different forms of software, firmware, and hardware in the implementations illustrated in the figures.", "The actual software code or specialized control hardware used to implement the various features is not limiting.", "Thus, the operation and behavior of the features were described without reference to the specific software code—it being understood that one of ordinary skill in the art would be able to design software and control hardware to implement the various features based on the description herein.", "Further, certain portions of the invention may be implemented as “logic” that performs one or more functions.", "This logic may include hardware, such as one or more processors, microprocessor, application specific integrated circuits, field programmable gate arrays or other processing logic, software, or a combination of hardware and software.", "In the preceding specification, various preferred embodiments have been described with reference to the accompanying drawings.", "It will, however, be evident that various modifications and changes may be made thereto, and additional embodiments may be implemented, without departing from the broader scope of the invention as set forth in the claims that follow.", "The specification and drawings are accordingly to be regarded in an illustrative rather than restrictive sense.", "No element, act, or instruction used in the description of the present application should be construed as critical or essential to the invention unless explicitly described as such.", "Also, as used herein, the article “a” is intended to include one or more items.", "Further, the phrase “based on” is intended to mean “based, at least in part, on” unless explicitly stated otherwise." ] ]
Patent_15874162
[ [ "DYNAMICALLY PROVISIONING SUBSCRIBERS TO MANAGE NETWORK TRAFFIC", "A system comprising: one or more server devices to: set a first network threshold level for determining network congestion in a network; set rate limiting criteria for determining when one or more subscribers will be rate limited; detect an increase in network congestion at a base station above the first network threshold level; identify one or more subscribers meeting one or more of the rate limiting criteria; rate limit network traffic associated with the one or more subscribers; detect a decrease in network congestion at the base station below a second network threshold level; and remove the rate limiting of the network traffic associated with the one or more subscribers." ], [ "1.A method comprising: setting a first network threshold level for determining network congestion in a network; detecting an increase in network congestion at a base station above the first network threshold level; selecting one or more subscribers accessing the network via the base station, wherein the one or more subscribers are selected based on usage categories associated with the one or more subscribers, wherein the usage categories correspond to whether network usage, associated with each subscriber of the one or more subscribers, exceeds a subscriber threshold level, wherein the subscriber threshold level is based on policy information associated with each subscriber, and wherein the policy information is based on a minimum amount of bandwidth reserved for each subscriber during a previous period of network usage associated with each subscriber; rate limiting, by the one or more servers, network traffic associated with the one or more subscribers, wherein the rate limiting includes sending a message to a network device indicating that the network traffic associated with the one or more subscribers is to be rate limited; detecting a decrease in network congestion at the base station below a second network threshold level; and removing the rate limiting on the one or more subscribers accessing the network via the base station in response to detecting the decrease.", "2.The method of claim 1, where setting the first network threshold level comprises: configuring policy information based at least one of: historic or current usage of the network by the one or more subscribers, reserving bandwidth for one or more other subscribers during particular times of the day, or reserving bandwidth for one or more other subscribers during times of particular levels of network congestion, and compiling the policy information to set the first network threshold level.", "3.The method of claim 1, wherein rate limiting network traffic associated with the one or more subscribers comprises: changing a quality of service (QoS) classification identifier (QCI) for data associated with the one or more subscribers; and instructing the network device to rate limit the network traffic based on the changed QCI.", "4.The method of claim 1, wherein selecting the one or more subscribers comprises: detecting the one or more subscribers when the one or more subscribers are associated with usage categories that correspond to network traffic that exceeds the subscriber threshold level.", "5.The method of claim 4, wherein detecting the one or more subscribers comprises: detecting historic usage data from a particular previous time period for the one or more subscribers; and detecting the one or more subscribers when the historic usage data exceeds the subscriber threshold level.", "6.The method of claim 4, wherein detecting the one or more subscribers comprises: detecting current usage data from a current time period for the one or more subscribers; and detecting the one or more subscribers when the current usage data exceeds the subscriber threshold level.", "7.The method of claim 4, further comprising: detecting one or more other subscribers associated with network traffic that does not exceed the subscriber threshold level; and rate increasing the network traffic associated with the one or more other subscribers.", "8.A system comprising: one or more devices configured to: set a first network threshold level to determine network congestion in a network; set rate limiting criteria to determine when subscribers will be rate limited, wherein the rate limiting criteria is based on usage categories associated with the subscribers, wherein the usage categories are based on whether network usage, associated with each of the subscribers, exceeds a subscriber threshold level associated with each of the subscribers, wherein the subscriber threshold level is based on policy information associated with each of the subscribers, and wherein the policy information is based on a minimum amount of bandwidth reserved for each of the subscribers during a previous period of network usage associated with each subscriber; detect an increase in network congestion at a base station above the first network threshold level; identify one or more subscribers meeting one or more of the rate limiting criteria; rate limit network traffic associated with the one or more subscribers by sending a message to a network device indicating that the network traffic associated with the one or more subscribers it to be rate limited; detect a decrease in network congestion at the base station below a second network threshold level; and remove the rate limiting of the network traffic associated with the one or more subscribers in response to detecting the decrease.", "9.The system of claim 8, wherein the one or more server devices set the first network threshold level by: configuring policy information based on at least one of: historic or current usage of the network by the one or more subscribers, reserving bandwidth for one or more other subscribers during particular times of the day, or reserving bandwidth for one or more other subscribers during times of particular levels of network congestion, and compiling the policy information to set the first network threshold level.", "10.The system of claim 8, wherein, when rate limiting the network traffic associated with the one or more subscribers, the one or more devices are further configured to rate limit the network traffic associated with the one or more subscribers by: changing a quality of service (QoS) classification identifier (QCI) for data associated with the one or more subscribers, and instructing the network device to rate limit the network traffic based on the changed QCI.", "11.The system of claim 8, wherein, when identifying the one or more subscribers meeting one or more of the rate limiting criteria, the one or more devices are further configured to: detect historic usage data from a particular previous time period for the one or more subscribers; and compare the historic usage data to the rate limiting criteria, where the rate limiting criteria includes a threshold amount of data for the particular previous time period for the one or more subscribers, and wherein the one or more subscribers meet the one or more rate limiting criteria when the historic usage data exceeds the threshold amount of data.", "12.The system of claim 8, wherein, when identifying the one or more subscribers meeting one or more of the rate limiting criteria, the one or more devices are further configured to: detect current usage data from a current time period for the one or more subscribers; and compare the current usage data to the rate limiting criteria, where the rate limiting criteria includes a threshold amount of data for the current time period for the one or more subscribers, and wherein the one or more subscribers meet the one or more rate limiting criteria when the current usage data exceeds the threshold amount of data.", "13.The system of claim 8, wherein the one or more devices comprise: a policy charging and rules function (PCRF) device configured to: receive load information to detect the increase in network congestion; change a quality of service (QoS) classification identifier (QCI), for the one or more subscribers, from a first value to a second value to rate limit the one or more subscribers; receive load information to detect the decrease in network congestion; and return the QCI from the second value to the first value to remove the rate limit in response to detecting the decrease.", "14.A non-transitory computer-readable medium comprising: one or more instructions that, when executed by at least one processor, cause the at least one processor to: set a first network threshold level for determining network congestion in a network; set rate limiting criteria for determining when subscribers will be rate limited, wherein the rate limiting criteria is based on usage categories associated with the subscribers, wherein the usage categories correspond to whether network usage, associated with each of the subscribers, exceeds a subscriber threshold level, wherein the subscriber threshold level is based on policy information associated with each of the subscribers, and wherein the policy information is based on a minimum amount of bandwidth reserved for each subscriber during a time of network usage associated with each subscriber; detect an increase in network congestion at a base station above the first network threshold level; identify one or more subscribers meeting one or more of the rate limiting criteria; rate limit network traffic associated with the one or more subscribers by sending a message to a network device indicating that the network traffic associated with the one or more subscribers is to be rate limited; detect a decrease in network congestion at the base station below a second network threshold level; and remove the rate limiting of the network traffic associated with the one or more subscribers in response to detecting the decrease.", "15.The computer-readable medium of claim 14, further comprising: one or more instructions that, when executed by at least one processor, cause the at least one processor to configure policy information based on at least one of: historic or current usage of the network by the one or more subscribers, reserving bandwidth for one or more other subscribers during particular times of the day, or reserving bandwidth for one or more other subscribers during times of particular levels of network congestion, and compile the policy information to set the first network threshold level.", "16.The computer-readable medium of claim 14, wherein the one or more instructions that cause the at least one processor to rate limit network traffic associated with the one or more subscribers comprise one or more instructions that, when executed by at least one processor, cause the at least one processor to rate limit network traffic associated with the one or more subscribers by: changing a quality of service (QoS) classification identifier (QCI) for data associated with the one or more subscribers; and instructing the network device to rate limit the network traffic based on the changed QCI.", "17.The computer-readable medium of claim 14, wherein the one or more instructions that cause the at least one processor to rate limit the network traffic associated with the one or more subscribers comprise one or more instructions that, when executed by at least one processor, cause the at least one processor to rate limit the network traffic by: detecting the one or more subscribers using amounts of data above the subscriber threshold level; and rate limiting the network traffic associated with the one or more subscribers using amounts of data above the subscriber threshold level.", "18.The computer-readable medium of claim 14, wherein the one or more instructions that cause the at least one processor to identify the one or more subscribers meeting the one or more of the rate limiting criteria further comprise one or more instructions that cause the at least one processor to: detect historic usage data from a particular previous time period for the one or more subscribers; and compare the historic usage data to the rate limiting criteria, wherein the rate limiting criteria includes a threshold amount of data for the particular previous time period for the one or more subscribers, and wherein the one or more subscribers meet the one or more rate limiting criteria when the historic usage data exceeds the threshold amount of data.", "19.The computer-readable medium of claim 14, wherein the one or more instructions that cause the at least one processor to identify the one or more subscribers meeting the one or more of the rate limiting criteria further comprise one or more instructions that cause the at least one processor to: detect current usage data from a current time period for the one or more subscribers; and compare the current usage data to the rate limiting criteria, wherein the rate limiting criteria includes a threshold amount of data for the current time period for the one or more subscribers, and wherein the one or more subscribers meet the one or more rate limiting criteria when the current usage data exceeds the threshold amount of data.", "20.The computer-readable medium of claim 14, further comprising: one or more instructions that, when executed by at least one processor, cause the at least one processor to: receive load information to detect the increase in network congestion; change a quality of service (QoS) classification identifier (QCI), for the one or more subscribers, from a first value to a second value to rate limit the one or more subscribers; receive load information to detect the decrease in network congestion; and return the QCI from the second value to the first value to remove the rate limit in response to detecting the decrease." ], [ "<SOH> BACKGROUND <EOH>A fourth generation (4G) wireless network is an Internet protocol (IP) wireless access network in which different advanced multimedia application services (e.g., voice over IP (VoIP) content, video content, etc.)", "are delivered over IP.", "As wireless network data rates improve using 4G technologies, more and more bandwidth-intensive applications and devices are being developed.", "For example, some mobile devices, such as smart mobile devices like iPhone and Android devices, may receive high bit rates of 10-50 megabits per second (Mbps) or more, which is significantly more data than a typical cellular phone.", "In a multiple access network, these different devices and multimedia application services compete for the same air interface and transport network resources.", "Quality of Service (QoS) refers to a measure of network performance.", "QoS issues may arise due to network problems, such as network congestion, latency, or jitter.", "Other QoS issues may arise due to faults or miscommunications with hardware (e.g., server devices, customer equipment, etc.).", "QoS problems can be exasperated when one or more subscribers utilize a disproportionately high amount of network bandwidth during times of otherwise high network congestion, which in turn can leave other subscribers with a disproportionately low amount of available network resources." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIGS.", "1A and 1B are diagrams illustrating an example environment in which systems and/or methods, described herein, may be implemented; FIG.", "2 is a diagram of example components of one or more of the devices of FIGS.", "1A and 1B ; FIG.", "3 is a diagram illustrating an example of a data structure that may be maintained by a traffic monitor according to an implementation described herein; FIG.", "4 is a diagram illustrating example communication paths between components of FIG.", "1B according to an implementation described herein; and FIG.", "5 is a flow chart of an example process for dynamically provisioning subscribers according to an implementation described herein.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/165,112, filed on May 26, 2016, which is a continuation of U.S. patent application Ser.", "No.", "13/407,031 filed on Feb. 28, 2012, now U.S. Pat.", "No.", "9,374,289, issued Jun.", "21, 2016, the contents of which are hereby incorporated herein by reference in their entirety.", "BACKGROUND A fourth generation (4G) wireless network is an Internet protocol (IP) wireless access network in which different advanced multimedia application services (e.g., voice over IP (VoIP) content, video content, etc.)", "are delivered over IP.", "As wireless network data rates improve using 4G technologies, more and more bandwidth-intensive applications and devices are being developed.", "For example, some mobile devices, such as smart mobile devices like iPhone and Android devices, may receive high bit rates of 10-50 megabits per second (Mbps) or more, which is significantly more data than a typical cellular phone.", "In a multiple access network, these different devices and multimedia application services compete for the same air interface and transport network resources.", "Quality of Service (QoS) refers to a measure of network performance.", "QoS issues may arise due to network problems, such as network congestion, latency, or jitter.", "Other QoS issues may arise due to faults or miscommunications with hardware (e.g., server devices, customer equipment, etc.).", "QoS problems can be exasperated when one or more subscribers utilize a disproportionately high amount of network bandwidth during times of otherwise high network congestion, which in turn can leave other subscribers with a disproportionately low amount of available network resources.", "BRIEF DESCRIPTION OF THE DRAWINGS FIGS.", "1A and 1B are diagrams illustrating an example environment in which systems and/or methods, described herein, may be implemented; FIG.", "2 is a diagram of example components of one or more of the devices of FIGS.", "1A and 1B; FIG.", "3 is a diagram illustrating an example of a data structure that may be maintained by a traffic monitor according to an implementation described herein; FIG.", "4 is a diagram illustrating example communication paths between components of FIG.", "1B according to an implementation described herein; and FIG.", "5 is a flow chart of an example process for dynamically provisioning subscribers according to an implementation described herein.", "DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS The following detailed description refers to the accompanying drawings.", "The same reference numbers in different drawings may identify the same or similar elements.", "A system and/or method, described herein, may dynamically provision network subscribers to manage network traffic.", "In an implementation described herein, an example system is provided that can dynamically provision network subscribers by throttling or rate limiting one or more subscribers during periods of high network congestion to alleviate network congestion.", "Dynamic provisioning can be based on subscriber usage, current or historic, in combination with current network conditions.", "For example, during periods of high network congestion, subscribers who use more than a threshold amount of data (e.g., heavy use subscribers) can be rate limited or throttled, such that their access to the network has lower priority than other subscribers who use less than the threshold amount of data (e.g., light use subscribers).", "By rate limiting heavy use subscribers, the additional congestion caused by their heavy use can be reduced, which can disproportionately alleviate network congestion compared to rate limiting light use subscribers.", "Alternatively, all subscribers can be subjected to rate limiting beyond a threshold level to allow for each subscriber to access a minimum amount of data even during periods of high network congestion, such that each subscriber can have a minimum guaranteed QoS.", "Subscribers can be dynamically provisioned by throttling or rate limiting one or more subscribers.", "In one implementation, one or more subscribers can be throttled or rate limited by one of several methods, such as adjusting priorities of network access or bit rates (e.g., changing the priority of the subscriber's packet forwarding), discarding packets (e.g., policing), delaying packets in transit (e.g., queuing), manipulating congestion mechanisms (e.g., congestion control), setting or changing transfer rate limits, etc.", "As used herein, the terms throttling and rate limiting are used interchangeably to describe throttling or rate limiting by any available mechanism including those listed above.", "One method of dynamic provisioning listed above can include adjusting priorities of network access or bit rates.", "In one implementation, heavy use subscribers can be rate limited by adjusting priorities on their packet forwarding priority (e.g., priority of forwarding their packets containing data and content requests over other subscribers' packets containing data and content requests).", "Priority assignments can be used to access base station 120-specific parameters that control packet forwarding priority.", "Based on priority assignments, the forwarding priority of packets can be pre-configured to send some packets with a higher priority than other packets.", "Depending on the wireless technology used, priority can be set in different ways.", "For example, dynamic provisioning can change a particular forwarding priority class to rate limit particular packets.", "For example, the forwarding priority class can be lowered for heavy use subscribers, thus rate limiting particular packets for the heavy use subscribers by lowering the forwarding priority for packets of the heavy use subscribers.", "Dynamic provisioning can also be done by any other method of rate limiting available.", "For example, in order to conserve bandwidth, bandwidth can be limited to all or some subscribers.", "Thus, if a subscriber attempts to utilize more than their allotted bandwidth, the subscriber would be rate limited to their allotted bandwidth.", "FIG.", "1A is a diagram illustrating an example environment 100 in which systems and/or methods, described herein, may be implemented.", "As shown in FIG.", "1A, example environment 100 can include a mobile device 110, a base station 120, a network 130, and a policy charging and rules function (PCRF) server 140.In one implementation, PCRF server 140 can be used to dynamically provision subscribers to manage network traffic.", "A single mobile device 110, base station 120, network 130, and PCRF server 140 have been illustrated in FIG.", "1A for simplicity.", "In practice, there may be additional mobile devices 110, base stations 120, networks 130, and/or PCRF servers 140.Mobile device 110 may include any device capable of communicating via a network.", "For example, mobile device 110 may correspond to a mobile communication device (e.g., a mobile phone, a smart phone, a personal digital assistant (PDA), or a wireline telephone), a computer device (e.g., a laptop computer, a tablet computer, or a personal computer), a gaming device, a set top box, or another type of communication or computation device.", "Base station 120 may include one or more computation and/or communication devices that receive voice and/or data and transmit that voice and/or data to mobile device 110.Base station 120 may also receive voice and/or data transmitted from mobile device 110.In one implementation, base station 120 may utilize LTE standards operating in a 700 MHz frequency band (e.g., base station 120 may be a base station in an LTE network).", "In the context of an LTE network, base station 120 may also be referred to as an eNodeB or eNB.", "Base station 120 may provide a radio interface for network 130.Base station 120 may be associated with one or more geographical service areas surrounding base station 120.The service areas may be referred to as wireless sectors that are defined by the radio range of base station 120.A single sector, corresponding to base stations 120, is shown as sector 190 in FIG.", "1B.", "Network 130 may include a network that provides connectivity to base station 120.Network 130 may include a local area network (LAN), a wide area network (WAN), a metropolitan area network (MAN), other types of networks, or a combination of networks.", "In one implementation, network 130 may take the form of an LTE network.", "In another implementation, other networks, such as a network that provides a wireless (radio) interface to mobile devices 110 using the 3rd generation (3G) mobile telecommunications standards, other 4th generation (4G) mobile telecommunications standards different from an LTE network, or future networks, such as a 5th generation (5G) network, may be used.", "4G networks can include, in addition to or as alternative to an LTE network, other radio access networks, such as an enhanced high rate packet data (eHRPD) network, and/or a wireless core network (e.g., referred to as an evolved packet core (EPC) network).", "An LTE network, such as network 130, is often called an evolved universal terrestrial radio access network (E-UTRAN).", "An EPC network can be an all-internet protocol (IP) packet-switched core network that supports high-speed wireless and wireline broadband access technologies.", "An evolved packet system (EPS) is defined to include an LTE (or eHRPD) network and an EPC network.", "PCRF server 140 may be a server that may access subscriber databases and other resources to make policy decisions relating to subscribers (e.g., users of mobile device 110).", "The policy decisions may relate to, for example, QoS decisions and charging rules.", "In one implementation, PCRF server 140 can be used to raise or lower bandwidths (e.g., maximum bit rate or average maximum bit rate) of subscribers, charge subscribers based on their volume of network data usage, charge subscribers for QoS guarantees, and/or limit application usage for certain events (e.g., time of day, load conditions, etc.).", "PCRF server 140 can decide to adjust bit rates or network priorities based on a number of factors, such as time of day, load conditions, subscriber information, policy information, etc.", "For example, during periods of heavy load conditions, PCRF server 140 can lower bit rates (e.g., throttle bit rates) or network priorities for heavy use subscribers to conserve bandwidth for the network.", "As another example, during periods of light load conditions, PCRF server 140 can raise bit rates or raise network priorities of subscribers including heavy use subscribers.", "PCRF server 140 can change network priorities by changing a QoS classification identifier (QCI) assigned to one or more subscribers.", "A QoS policy may include one or more forwarding classifications (e.g., QCI values) that correspond to one or more types of traffic and/or services (e.g., streaming video, streaming audio, Internet traffic, gaming, data, etc.)", "being transported via a network.", "Each type of traffic and/or service may be associated with a respective QCI value (e.g., 1, 2, 3, etc.)", "that corresponds to a respective forwarding priority, data rate, bandwidth, probability of packet loss, etc.", "for each type of traffic and/or service.", "QCI values control packet forwarding treatment (e.g., scheduling weights, admission thresholds, queue management thresholds, etc.).", "QCI can be pre-configured and can be used to determine packet forwarding by assigning a QCI value to a packet, and treating the packet according the QCI value and the corresponding packet forwarding treatment.", "For example, a QCI value of 1-9 can have a network priority of 1-9 for LTE networks.", "Based on the network priority, packets with lower QCI priority can have priority over other packets with higher QCI priority.", "For example, a packet with a QCI priority of 8 would have a higher QCI priority than a packet with a QCI priority of 9.A QCI priority can also be changed based on loading for selected subscribers to dynamically provision subscribers and manage network traffic.", "PCRF server 140 can increase or decrease the QCI priorities assigned to one or more subscribers to increase or decrease the packet priority and, thus, the level of service available to the one or more subscribers.", "In one implementation, the QCI can be lowered for heavy use subscribers during peak network congestion to increase the availability of bandwidth during the peak network congestion.", "For example, during times of high network congestion, the QCI priority can be decreased for heavy application subscribers.", "By lowering the QCI priority, the forwarding priority, data rate, bandwidth, probability of packet loss, etc.", "for each type of traffic and/or service can be reduced and can allow higher QCI traffic and/or service to experience increased QoS for all subscribers except the heavy use subscribers.", "For example, during times of heavy load, heavy use subscribers using a QCI with a priority of 8, can be changed to a QCI with a priority of 9 to lower the network priority for the heavy use subscribers to below light use subscribers, who could still be using a QCI with a priority of 8 (e.g., a higher priority than heavy use subscribers).", "Alternatively, the QCI can be changed based on loading for all subscribers to dynamically provision subscribers and manage network traffic.", "In one implementation, the QCI can be lowered for all subscribers such that each subscriber's QCI is a minimum level.", "For example, the QCI can be set for each subscriber to a minimum QoS during peak network congestion.", "Additionally, or alternatively, PCRF server 140 can move or offload heavy use subscribers to other technologies.", "For example, PCRF server 140 can move heavy use subscribers from an LTE network to a 3G network.", "Subscribers can be identified or classified by their usage, such as threshold amounts and/or usage within specific time periods.", "In one implementation, a threshold can be set at a fixed amount of bandwidth or a percentage of the bandwidth (e.g., during high, medium, and/or low network congestion periods).", "For example, a subscriber can also be identified as a heavy use subscriber if the subscriber exceeds 10% of the bandwidth for a base station 120.In another implementation, the type of subscriber can be taken into account for identification and classification.", "For example, premium subscribers can be differentiated from regular subscribers and heavy use premium subscribers can be exempted from having their bandwidth throttled.", "In one implementation, usage within specific time periods can be set based upon usage over a set amount of time (e.g., the past week, a previous billing cycle, the past year, etc.)", "or within a moving window (e.g., current usage, or the past 20 minutes, 60 minutes, 2 hours, etc.", "of usage).", "For example, a subscriber can be identified as a heavy use subscriber if the subscriber uses a high amount of data over the past week or within the last 20 minutes.", "In another implementation, a heavy use subscriber can be identified based on a weighting of historic usage and current usage in base station 120.For example, a heavy use subscriber can be identified by heavy usage over the past month in combination with moderate current usage.", "While implementations herein are described primarily in the context of broadband services via LTE, other wireless protocols may be used.", "For example, components conforming to LTE standards described herein may be replaced by components conforming to other network protocols (e.g., Global System for Mobile Communications (GSM), wideband code division multiple access (WCDMA), Ultra Mobile Broadband (UMB), Universal Mobile Telecommunications System (UMTS), Code Division Multiple Access 2000 (CDMA2000), High-Speed Packet Access (HSPA), Worldwide Interoperability for Microwave Access (WiMax), etc.).", "FIG.", "1B is a diagram illustrating an example environment 100 in which systems and/or methods, described herein, may be implemented.", "As shown in FIG.", "1B, example environment 100 can include mobile devices 110, base stations (eNodeB or eNB) 120, network 130, PCRF server 140, packet network 150, and content server 160.Network 130 may provide wireless broadband services to a number of mobile devices 110.The components of network 130 may include base stations (eNBs) 120 with sectors 190, a packet data network gateway (PGW) 170, and a traffic monitor 180.In general, a number of other networks devices, which are not shown herein for clarity, may also be used in the implementation of network 130.Network 130 may also connect to other networks, such as an external packet network 150.In some implementations, in addition to serving mobile devices 110, network 130 may also provide wireless service to stationary internet devices, such as wireless hubs, that can connect a home computer or router to a wireless network.", "Packet network 150 may include, for example, a public packet-based network, such as the Internet.", "One or more servers, such as content server 160, may be connected to or located within packet network 150.Content server 160 may include devices designed to provide content to mobile device 110.The provided content may include, for examples, movies, television shows, or other multimedia content, that is delivered to mobile device 110 in response to a request from mobile device 110.The video may be delivered, for instance, as IP unicast traffic.", "Although content server 160 is shown as part of packet network 150, in an alternative implementation, content server 160 may be part of another network, such as network 130 and/or an LTE network.", "PGW 170 may include one or more devices that may be connected to packet network 150 and connected to or located within network 130.PGW 170 may provide connectivity to external networks, such as packet network 150.Mobile device 110 may have simultaneous connectivity with more than one PGW 170 to multiple additional networks.", "PGW 170 may perform, for example, policy enforcement, packet filtering for each subscriber, charging support, lawful interception, and/or packet screening.", "Traffic monitor 180 may include one or more devices that monitor traffic at base stations 120.In one implementation, traffic monitor 180 may keep track of the radio interfaces of base stations 120.For example, traffic monitor 180 may track the total number of connected subscribers in each of sectors 190, the total bandwidth being used in sectors 190, the amount of free bandwidth in each of sectors 190, and/or some other metric relating to a current congestion or load level at base station 120.Traffic monitor 180 may receive information relating to the load/congestion of a sector 190 from base stations 120 and/or from PGW 170.Traffic monitor 180 and PCRF server 140 (along with other components in environment 100) can work together to monitor QoS for one or more subscribers in a sector 190, and to adjust the QCI for one or more subscribers based upon the monitored QoS to dynamically provision bandwidths for subscribers to manage network traffic.", "Although FIG.", "1B illustrates components in a portion of environment 100, in other implementations, the portion of environment 100 may include additional components, fewer components, different components, or differently arranged components than those illustrated in FIGS.", "1A and 1B, and described herein.", "Alternatively, or additionally, one or more components of the portion of environment 100 may perform one or more tasks described as being performed by one or more other components of the portion of environment 100.FIG.", "2 is a diagram of example components of a device 200 that may correspond to one of the components of mobile device 110, base station 120, network 130, or packet network 150 (e.g., content server 160, PGW 170, PCRF server 140, traffic monitor 180, etc.).", "As illustrated, device 200 may include a bus 210, a processing unit 220, a memory 230, an input component 240, an output component 250, and a communication interface 260.Bus 210 may permit communication among the components of device 200.Processing unit 220 may include one or more processors or microprocessors that interpret and execute instructions.", "Additionally or alternatively, processing unit 220 may be implemented as or include one or more application specific integrated circuits (ASICs), field programmable gate arrays (FPGAs), or the like.", "Memory 230 may include a random access memory (RAM) or another type of dynamic storage device that stores information and instructions for execution by processing unit 220, a read only memory (ROM) or another type of static storage device that stores static information and instructions for the processing unit 220, and/or some other type of magnetic or optical recording medium and its corresponding drive for storing information and/or instructions.", "Input component 240 may include a device that permits an operator to input information to device 200, such as a button, a switch, a keyboard, a keypad, a mouse, or the like.", "Output component 250 may include a device that outputs information to the operator, such as a display, a speaker, a light emitting diode (LED), etc.", "Communication interface 260 may include any transceiver-like mechanism that enables device 200 to communicate with other devices and/or systems.", "For example, communication interface 260 may include receiver and/or transmitter components for communicating with other devices.", "As described herein, device 200 may perform certain operations in response to processing unit 220 executing software instructions contained in a computer-readable medium, such as memory 230.A computer-readable medium may be defined as a non-transitory memory device.", "A memory device may include space within a single physical memory device or spread across multiple physical memory devices.", "The software instructions may be read into memory 230 from another computer-readable medium or from another device via communication interface 260.The software instructions contained in memory 230 may cause processing unit 220 to perform processes described herein.", "Alternatively, hardwired circuitry may be used in place of or in combination with software instructions to implement processes described herein.", "Thus, implementations described herein are not limited to any specific combination of hardware circuitry and software.", "Although FIG.", "2 shows example components of device 200, in other implementations, device 200 may contain fewer components, different components, differently arranged components, or additional components than depicted in FIG.", "2.Alternatively, or additionally, one or more components of device 200 may perform one or more tasks described as being performed by one or more other components of device 200.FIG.", "3 is a diagram illustrating an example of a data structure 300 that may be maintained by traffic monitor 180 according to an LTE implementation described herein.", "Data structure 300 may include LTE base station (LTE BS) field 310 and load field 320.LTE base station field 310 may store, for each entry in data structure 300, a value identifying a particular base station 120.LTE base station field 310 may include, for example, a character sequence that uniquely identifies a particular base station 120 in network 130.In an alternative implementation, instead of identifying base stations 120, LTE base station field 310 may identify particular sectors maintained by base stations 120.Load field 320 may store an indication of the traffic load that is being experienced by the corresponding base station 120.In various implementations, the traffic load for base station 120 may be expressed in a number of ways, such as an average traffic load of base station 120 over a predetermined time period, the peak load in the sector over a predetermined time period, a number of subscribers connected to base station 120, etc.", "In the example of FIG.", "3, load field 320 may be expressed as the aggregate average load for base station 120 over a certain period, such as the previous 10 minutes.", "Thus, for the base station 120 labeled “bs1,” the average load over the last 10 minutes is illustrated as 100 Mbps (mega bits per second), and for base station 120 labeled “bs2,” the average load over the last 10 minutes is illustrated as 200 Mbps.", "The fields shown for data structure 300 are examples of possible fields that may be maintained by traffic monitor 180.In alternative implementations, different fields, additional fields, or fewer fields may be used in data structure 300.FIG.", "4 is a diagram illustrating example communication paths between components of FIG.", "1B according to an implementation described herein.", "As illustrated in FIG.", "4, base stations 120 can connect via traffic monitor 180 to PCRF server 140 and PGW 170.Sector load information 410 may be periodically or occasionally received, by traffic monitor 180, from base stations 120 and/or from PGW 170.Sector load information 410 may include the average traffic load of a sector and/or base station 120 over a predetermined time period, the peak load in the sector and/or base station 120 over the predetermined time period, etc.", "Sector load information 410 can indicate whether network congestion or QoS problems may be occurring at base station 120.Traffic monitor 180 may maintain and may provide network load information 420 to PCRF server 140 based on sector load information 410 for various sectors 190 of network 130.Network load information 420 may be provided to PCRF server 140 at certain intervals or on request from PCRF server 140.For example, PCRF server 140 may send a request to traffic monitor 180 for the current network load information 420 associated with a particular base station 120 or sector 190.In response, traffic monitor 180 may find the network load information 420 and transmit the network load information 420 to PCRF server 140.A number of communication paths are illustrated in FIG.", "4.Additional, different, or fewer communication paths may, in some implementations, be used in network 130.FIG.", "5 is a flow chart of an example process 500 for dynamically provisioning subscribers according to an implementation described herein.", "Process 500 may allow for dynamic provisioning of subscribers into a load priority queue or to regulate QCI and network traffic in a network.", "Process 500 may include configuring subscriber information (block 510).", "The configuring may be performed by one or more server devices, such as PCRF server 140.The subscriber information can be used to adjust policies for specific subscribers based upon their subscriptions to standard and premium services (e.g., QoS guarantees, higher network usage packages, etc.)", "or other factors that may be subscriber specific (e.g., long term customer, network administration, special customer status, etc.).", "In one implementation, subscriber information can be configured based on information regarding a specific subscriber.", "For example, subscriber information can be configured to include information from subscriber databases, such as a subscriber billing database, which can indicate whether a subscriber opts to purchase QoS guarantees, has a history of heavy network usage over a particular threshold of use over a time period, such as a billing cycle, is currently using network data above a particular threshold in a particular base station 120, etc.", "Additionally, the subscriber information can be configured based on weighting certain factors more heavily than other factors.", "For example, opting to purchase QoS guarantees and current network usage can be given more weight to configuring subscriber information than historical network usage.", "The subscriber information may define threshold information for a load value at which a subscriber's network access may be throttled down (e.g., the subscriber will have slower or reduced priority access to the network).", "The threshold information may be, for example, statically programmed by an administrator.", "Alternatively, the threshold information may be dynamically determined based on, for example, the total capacity of a particular base station 120 or based on other information.", "In some implementations, a threshold value may be set for all base stations 120.Alternatively, the threshold values may be set on a per-base station 120 basis.", "In other words, the threshold value for one base station 120 may differ from the threshold value for another base station 120.Process 500 may include configuring policy information (block 520).", "The configuring may be performed by one or more server devices, such as PCRF server 140.The policy information can be used to determine which policies should be applied to one or more specific subscribers based upon policies set for particular categories of subscribers.", "For example, policy information can include lowering QCI for specific subscribers based upon their subscriber information matching with particular policies (e.g., QoS guarantees for specific subscribers being enforced according to policy information).", "In one implementation, policy information can be configured based on information regarding the network and policies set by the network administration.", "For example, policy information may be configured to throttle usage of heavy subscribers based on their subscriber information, reserve network bandwidth for subscribers who pay for QoS guarantees, reserve a minimal amount of bandwidth for each subscriber during their historic times of use (e.g., if a subscriber primarily accesses the network from 6-7 am, the policy can be configured to reserve a particular amount of bandwidth for that subscriber from 6-7 am), etc.", "Process 500 may include monitoring load level and/or QoS of base stations 120 (block 520).", "Monitoring load level and/or QoS of base stations 120 can be performed by one or more server devices, such as traffic monitor 180.Monitoring load level and/or QoS of base stations 120 can be performed to identify QoS degradation and to identify any specific subscribers that may experience the identified QoS degradation.", "In one implementation, traffic monitor 180 can monitor one or more base stations 120 to monitor the condition of load level and/or QoS of base stations 120 for QoS degradation (e.g., network congestion, latency, or jitter).", "Process 500 may include classifying subscribers into usage categories (block 540).", "Classifying subscribers into usage categories can be performed by one or more server devices, such as PCRF server 140.Subscribers can be classified into any identifiable category, such as heavy users, light users, prime time users, off time users, etc., and can be used to dynamically provision subscribers into a load priority queue based upon whether each subscriber exceeds one or more threshold levels.", "One or more threshold levels can be determined by the subscriber information and/or the policy information that apply to each specific subscriber or a category of subscribers.", "For example, a subscriber (or category of subscribers) can have a higher threshold level if the subscriber (or category of subscribers) pays for higher QoS guarantees, or a lower threshold level if they do not pay for QoS guarantees.", "In one implementation, subscribers can be classified into usage categories, such as heavy subscribers if their network usage, historically or currently, exceed their threshold level(s).", "For example, a subscriber can be classified as a heavy user if the subscriber's current or historic usage exceeds the subscriber's threshold historically, during specific times, during particular events, etc.", "Likewise, a subscriber can be classified as a light user if the subscriber's current or historic usage did not exceed the subscriber's threshold historically, during specific times, during particular events, etc.", "Process 500 may include rate limiting select subscribers (block 550).", "Rate limiting select subscribers can be performed by one or more server devices, such as PCRF server 140 possibly in combination with base stations 120 and PGW 170.Rate limiting select subscribers can be based on the policy information, classifications of the select subscribers (including subscriber information), such as usage category classifications (e.g., heavy use subscribers, average use subscribers, light use subscribers), network congestion, and/or the access sought by the select subscribers.", "In one implementation, rate limiting can be done by PCRF server 140 to select subscribers that meet a particular classification according to policy and subscriber information along with network information.", "Rate limiting can occur by identifying network packets with particular QCI (that can be marked by PGW 170) and enforcing the particular QCI by base stations 120 for packet control.", "For example, QCI for network packets can be changed to different QCI for select subscribers, as identified by one or more usage categories, to rate limit the select subscribers.", "Additionally, rate limiting can be applied on a per base station 120 basis.", "In one implementation, rate limiting can be applied to base stations 120 that have high network congestion causing QoS problems, but not applied to base stations 120 that have low network congestion and are not suffering from network congestion causing QoS problems.", "For example, load level and/or QoS can be monitored and network congestion can be found on a specific base station 120.This specific base station 120 can have rate limiting occur for select subscribers to alleviate network congestion on this specific base station 120, while other non-network congested base stations 120 can continue without triggering rate limitations on similarly categorized subscribers.", "Process 500 may include withdrawing rate limitations (block 560).", "Withdrawing rate limitations can be performed by one or more server devices, such as PCRF server 140 possibly in combination with base stations 120 and PGW 170.Withdrawing rate limitations can be based on the policy information, classifications of the select subscribers (including subscriber information), network congestion, and/or the access sought by the select subscribers.", "In one implementation, withdrawing rate limitations can be done when the period of high network congestion ends.", "For example, PCRF server 140 can remove rate limitation when the network congestion at base station 120 returns to a non-congested state.", "In one implementation, a first threshold can be used to determine that network congestion exists when the network traffic exceeds the first threshold, and a second threshold can be used to determine that network congestion no longer exists when the network traffic does not exceed the second threshold.", "Additionally, the first threshold can be the same or different from the second threshold.", "For example, the first threshold can be a value higher than the second threshold to allow for a delay in rate limiting, but still allow for network congestion alleviation until the network congestion period ends.", "A system and/or a method described herein may provide dynamic provisioning of subscribers to manage network traffic.", "Dynamic provisioning can be provided by monitoring load conditions, and dynamically adjusting priority settings for accessing the network by rate limiting select subscribers during times of heavy network congestion and removing the limitations for these select subscribers during times of light network congestion.", "Dynamic provisioning may also account for subscription by subscribers to premium services, which can allow premium subscribers to not be limited during times of heavy network congestion, or to have accessed to increased bandwidth during all times.", "The foregoing description provides illustration and description, but is not intended to be exhaustive or to limit the implementations to the precise form disclosed.", "Modifications and variations are possible in light of the above disclosure or may be acquired from practice of the implementations.", "While a series of blocks has been described with regard to FIG.", "5, the order of the blocks may be modified in other implementations.", "Further, non-dependent blocks may be performed in parallel.", "It will be apparent that systems and/or methods, as described above, may be implemented in many different forms of software, firmware, and hardware in the implementations illustrated in the figures.", "The actual software code or specialized control hardware used to implement these systems and methods is not limiting of the embodiments.", "Thus, the operation and behavior of the systems and methods were described without reference to the specific software code--it being understood that software and control hardware can be designed to implement the systems and methods based on the description herein.", "Further, certain portions, described above, may be implemented as a component that performs one or more functions.", "A component, as used herein, may include hardware, such as a processor, an ASIC, or a FPGA, or a combination of hardware and software (e.g., a processor and executing software).", "It should be emphasized that the terms “comprises”/“comprising” when used in this specification are taken to specify the presence of stated features, integers, steps or components but does not preclude the presence or addition of one or more other features, integers, steps, components or groups thereof.", "Even though particular combinations of features are recited in the claims and/or disclosed in the specification, these combinations are not intended to limit the disclosure of the embodiments.", "In fact, many of these features may be combined in ways not specifically recited in the claims and/or disclosed in the specification.", "Although each dependent claim listed below may directly depend on only one other claim, the disclosure of the embodiments includes each dependent claim in combination with every other claim in the claim set.", "No element, act, or instruction used in the present application should be construed as critical or essential to the embodiments unless explicitly described as such.", "Also, as used herein, the article “a” is intended to include one or more items.", "Where only one item is intended, the term “one” or similar language is used.", "Further, the phrase “based on” is intended to mean “based, at least in part, on” unless explicitly stated otherwise." ] ]
Patent_15874164
[ [ "MEMORY INTERFACE INITIALIZATION WITH PRECESSOR IN RESET", "A device comprises control circuitry including a processor, a memory interface, memory interface initialization circuitry, and non-volatile storage storing initialization parameters for initializing the memory interface.", "The control circuitry is configured to, while the processor is held in reset, initialize the memory interface using the initialization parameters and the memory interface initialization circuitry, after the memory interface has been initialized, receive instructions from a non-volatile memory module over the memory interface, and, after the processor has been released from reset, execute the instructions using the processor." ], [ "1.A device comprising: control circuitry comprising: a processor; a memory interface; memory interface initialization circuitry; and non-volatile storage storing initialization parameters for initializing the memory interface; wherein the control circuitry is configured to: while the processor is held in reset, initialize the memory interface using the initialization parameters and the memory interface initialization circuitry; after the memory interface has been initialized, receive instructions from a non-volatile memory module over the memory interface; and after the processor has been released from reset, execute the instructions using the processor.", "2.The device of claim 1, wherein the control circuitry is further configured to, while the processor is held in reset, train the memory interface using the initialization parameters and the memory interface initialization circuitry.", "3.The device of claim 1, wherein the memory interface initialization circuitry comprises state machine circuitry.", "4.The device of claim 1, wherein the non-volatile storage comprises one-time programmable data storage.", "5.The device of claim 4, wherein the one-time programmable data storage comprises a plurality of hardware registers.", "6.The device of claim 1, wherein the control circuitry comprises an application-specific integrated circuit (ASIC).", "7.The device of claim 1, wherein the memory interface initialization circuitry comprises a field-programmable gate array.", "8.The device of claim 1, wherein the initialization parameters indicate characteristics of a data transmission path that couples the memory interface initialization circuitry to the non-volatile memory module.", "9.The device of claim 8, wherein the data transmission path is associated with a printed circuit board on which the control circuitry and the non-volatile memory module are mounted.", "10.The device of claim 1, wherein the initialization parameters indicate characteristics of the non-volatile memory module.", "11.The device of claim 1, wherein: the control circuitry is further configured to, while the processor is held in reset, read bootstrap option data; and said initializing the memory interface is based at least in part on the bootstrap option data.", "12.A method of executing instructions in a device, the method comprising: while a processor of a device is held in reset: accessing initialization parameters stored in non-volatile storage of the device; providing the initialization parameters to memory interface initialization circuitry; and initializing a memory interface of the device using the initialization parameters and the memory interface initialization circuitry; after the memory interface has been initialized, receiving instructions from a non-volatile memory module over the memory interface; and after the processor has been released from reset, executing the instructions using the processor.", "13.The method of claim 12, wherein the memory interface is a double data rate (DDR) interface.", "14.The method of claim 12, wherein the non-volatile storage comprises one or more hardware registers.", "15.The method of claim 14, wherein the one or more hardware registers comprise one or more fuses burned during a manufacturing process.", "16.The method of claim 12, further comprising, while the processor is held in reset, reading bootstrap option data, wherein said initializing the memory interface is based at least in part on the bootstrap option data.", "17.The method of claim 12, further comprising, while the processor is held in reset, training the memory interface using the initialization parameters and the memory interface initialization circuitry.", "18.The method of claim 12, wherein the memory interface initialization circuitry comprises state machine circuitry.", "19.The method of claim 12, wherein: the initialization parameters indicate characteristics of a data transmission path that couples the memory interface initialization circuitry to the non-volatile memory module; and the data transmission path is associated with a board on which the memory interface is mounted.", "20.A data storage device comprising: a non-volatile memory module; and control circuitry comprising: a processor; a memory interface; memory interface initialization circuitry; and non-volatile storage storing initialization parameters for initializing the memory interface; wherein the control circuitry is configured to: while the processor is held in reset, initialize the memory interface using the initialization parameters and the memory interface initialization circuitry; after the memory interface has been initialized, receive instructions from the non-volatile memory module over the memory interface; and after the processor has been released from reset, execute the instructions using the processor." ], [ "<SOH> BACKGROUND <EOH>In computing devices and/or systems, firmware may be copied to a memory module for execution therefrom by one or more processors.", "Communication between processors and memory modules may require initialization of a communication interface configured to facilitate such communication." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Various embodiments are depicted in the accompanying drawings for illustrative purposes, and should in no way be interpreted as limiting the scope of this disclosure.", "In addition, various features of different disclosed embodiments can be combined to form additional embodiments, which are part of this disclosure.", "FIG.", "1 is a block diagram of an electronic device according to an embodiment.", "FIG.", "2 is a block diagram of a computing or electronic device according to an embodiment.", "FIG.", "3 is a block diagram of a computing or electronic device according to an embodiment.", "FIG.", "4 is a flow diagram illustrating a process for executing firmware in a computing or electronic device according to an embodiment.", "FIG.", "5 is a flow diagram illustrating a process for executing firmware in a computing or electronic device according to an embodiment.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "RELATED APPLICATION This application is a continuation of U.S. patent application Ser.", "No.", "14/675,531, filed on Mar.", "31, 2015, entitled COMMUNICATION INTERFACE INITIALIZATION, the disclosure of which is hereby incorporated by reference in its entirety.", "BACKGROUND In computing devices and/or systems, firmware may be copied to a memory module for execution therefrom by one or more processors.", "Communication between processors and memory modules may require initialization of a communication interface configured to facilitate such communication.", "BRIEF DESCRIPTION OF THE DRAWINGS Various embodiments are depicted in the accompanying drawings for illustrative purposes, and should in no way be interpreted as limiting the scope of this disclosure.", "In addition, various features of different disclosed embodiments can be combined to form additional embodiments, which are part of this disclosure.", "FIG.", "1 is a block diagram of an electronic device according to an embodiment.", "FIG.", "2 is a block diagram of a computing or electronic device according to an embodiment.", "FIG.", "3 is a block diagram of a computing or electronic device according to an embodiment.", "FIG.", "4 is a flow diagram illustrating a process for executing firmware in a computing or electronic device according to an embodiment.", "FIG.", "5 is a flow diagram illustrating a process for executing firmware in a computing or electronic device according to an embodiment.", "DETAILED DESCRIPTION While certain embodiments are described, these embodiments are presented by way of example only, and are not intended to limit the scope of protection.", "Indeed, the novel methods and systems described herein may be embodied in a variety of other forms.", "Furthermore, various omissions, substitutions and changes in the form of the methods and systems described herein may be made without departing from the scope of protection.", "The headings provided herein are for convenience only and do not necessarily affect the scope or meaning of the claims.", "Disclosed herein are example configurations and embodiments relating to direct execution of firmware from an interface-connected non-volatile memory module.", "Overview In electronic devices, initial boot-up processes may cause one or more processors to execute boot loader code from, for example, an internal non-volatile memory (e.g., read only memory (ROM)).", "Boot-up processes may further involve transitioning to a vector directed at least in part by external bootstrap options and further reading from a specific boot device (e.g., serial peripheral interface (SPI) flash) to load additional boot loader code and/or device firmware.", "The external code provided by the boot device may include certain initialization parameters for “training” a communication interface (e.g., double data rate (DDR) interface) allowing the controller of the device to communicate with one or more additional peripheral/external memory modules (e.g., volatile DDR memory).", "Booting and initialization from a specific boot device (e.g., SPI flash) may therefore require a boot interface and boot flash chip in addition to memory to build a system, which can introduce cost and/or design issues.", "With the advent of non-volatile memory (NVM) that utilizes DDR interfaces, it may be desirable in certain systems/devices to boot a processor directly from a device attached to a DDR interface or other interface for communicating with non-volatile memory external to the device controller (e.g., SoC).", "Generally, a DDR interface may need to be trained according to implementation-specific initialization parameters in order to allow for proper functioning.", "As disclosed in detail herein, adding non-volatile parameter storage in addition to a particularly-configured hardware training state machine to a device controller can allow the hardware to train the DDR interface without requiring initialization parameters and/or code to be fetched from a peripheral device.", "Once the DDR interface is trained, the processor(s) may be able to boot from the non-volatile memory module attached to the DDR interface, rather than requiring code to be fetched from an internal boot ROM or external serial flash device, for example.", "According to certain embodiments, initialization parameters and/or boot code that would otherwise be stored in an external specific boot device may be maintained in non-volatile hardware devices of the device controller.", "The controller may further include a hardware state machine that is configured to read the parameters and perform interface training based thereon; the parameters may be used to seed the interface (e.g., DDR) to enable training of the interface.", "Certain embodiments disclosed herein, by providing for booting directly from a non-volatile DDR module, may allow for elimination of one or more devices or components that may otherwise be required for booting and/or interface initialization, thereby potentially providing substantial cost savings, as well as reduced size/area requirements.", "Furthermore, embodiments disclosed herein may provide for initialization/training of communication interface(s) without requiring execution of any code by device/system processor(s).", "In certain embodiments, the first code that is executed by processor(s) in connection with booting of a computing device is from a DDR-attached module/device pre-loaded with the necessary code.", "System Overview FIG.", "1 is a block diagram illustrating an electronic device 100 according to one or more embodiments disclosed herein.", "The electronic device 100 may be a computing device or any other electronic device.", "For example, in certain embodiments, the electronic device 100 may be a data storage device configured to provide data storage services to a host system (not shown).", "The electronic device 100 includes a plurality of components, some of which are illustrated in the diagram of FIG.", "1.In certain embodiments, one or more of the illustrated components may be mounted to, or otherwise associated with, one or more controller boards 105, which may be, for example, printed circuit boards (PCBs).", "In such a configuration, the controller board(s) 105 and the one or more components mounted thereto or associated therewith may be referred to herein as a printed circuit board assembly (PCBA).", "The controller 130 may be a single chip or module, such as a system on a chip (SoC).", "In certain embodiments, the controller 130 includes one or more processors 132.For example, the one or more processors 132 may be microprocessors.", "In certain embodiments, the controller 130 may further comprise one or more hardware registers 134, which may be configured to store data.", "The controller 130 may be configured to communicate with one or more other components of the controller board 105 and/or electronic device 100.To facilitate such communication, the controller 130 may comprise one or more communication interfaces.", "For example, the controller 130 may include a memory interface 136 for communicating with a memory module, such as the volatile memory module 150.In certain embodiments, volatile memory module 150 may be configured to communicate over a double data rate (DDR) interface.", "The volatile memory module 150 may comprise one or more volatile memory chips 155, such as random access memory (RAM) chips.", "The volatile memory module 150 may further comprise a serial presence detect (SPD) chip configured to store one or more parameters 153 associated with the volatile memory module 150.For example, the parameters 153 may define one or more attributes of the memory chip(s) 155, such as timing, physical layout, chip number and/or configuration, trace length, tolerances, or the like.", "In certain embodiments, the volatile memory module 150 is not connected through a connector slot, but is hardwired to the controller board.", "Furthermore, in certain embodiments, the controller 130 is preprogrammed with the necessary parameters of the volatile memory module 150, such that no retrieval of parameters from the volatile memory module 150 is necessary.", "In order for the controller 130 to communicate with the volatile memory module 150 over the interface 136, it may be necessary for the interface to be first initialized and/or trained.", "Therefore, in order to communicate with the volatile memory module 150, the controller 130 may access or otherwise acquire initialization parameters associated with the interface 136 and perform initialization/training using such parameters.", "In certain embodiments, the controller 130 may acquire the initialization parameters for initializing the interface 136 from one or more non-volatile memory modules, such as the non-volatile memory 160, which may be, for example, a serial peripheral interface (SPI) flash memory module, wherein the memory 160 stores boot code for booting the electronic device and/or firmware for execution by the controller in operating the electronic device 100.The controller 130 may be further configured to communicate with hardware strap circuitry 140, which may provide certain system configuration data.", "The hardware strap circuitry 140 may comprise one or more pins that may be strapped up or down via a hardware resistor or the like, wherein the controller 130 is configured to read the pins and configure functionality based thereon.", "The hardware strap data may be read prior to execution of firmware controlled mechanisms.", "With respect to the electronic device 100, there may be various methods for code booting the processor(s) 132 selected by bootstrap options.", "For example, booting may be implemented from a parallel bus NOR flash device with a chip select, from a serial flash device via an SPI interface, or from an external device.", "With the advent of non-volatile memories incorporating DDR interfaces for speed, the opportunity arises to also boot from such external non-volatile DDR devices.", "However, in order to boot from an external DDR memory, it may be necessary for the controller 130 to first initialize the peripheral interface associated with the memory.", "Certain embodiments disclosed herein provide for the inclusion of a set of programmable non-volatile registers, or other internal hardware non-volatile memory, for storing the DDR training parameters, as well as a state machine (not shown) that may be used to perform the training.", "Such a configuration may obviate the need to fetch any code from external memory in order to initialize the interface.", "Therefore, the processor(s) 132 may be able to boot from a non-volatile memory module attached to the DDR interface.", "Furthermore, maintaining the initialization parameters within a separate non-volatile register array may allow for custom programming for a specific design or layout.", "Thus, with these parameters separate from the controller's internal boot loader memory chip, the device may be programmable to various different DDR layouts.", "It should be understood that the initialization parameters for initialization of the memory interface 136, as described herein, may be separate from the SPD parameters 153 shown.", "As described, the use of a non-volatile DDR memory for booting may eliminate the need for a separate boot interface and boot device.", "Furthermore, the non-volatile DDR memory may also replace the need for a separate volatile DDR memory for use as main memory (e.g., DRAM), thereby providing a system having minimal circuitry/components.", "FIG.", "2 is a more detailed block diagram of a computing or electronic device, and may correspond in certain respects to the electronic device 100 shown in FIG.", "1 and described above.", "The device of FIG.", "2 includes a controller 230 which comprises one or more processors 232, such as microprocessors or the like.", "The controller 230 may further include one or more internal non-volatile memory modules 231 and/or internal volatile memory modules 233.For example, the internal non-volatile memory 231 may comprise a read only memory (ROM) configured to store certain boot code or other code that is desirable to be maintained by the controller in a persistent manner.", "The controller may be configured to fetch boot code from the internal non-volatile memory 231, as well as additional boot code from the non-volatile memory 260.By retrieving code from the internal memory 231 and/or the external memory 260, the controller 130 may be able to implement hardware initialization under firmware control.", "For example, the controller 130 may implement initialization and/or training of the memory interface 236 under firmware control.", "The internal volatile memory 231 may be, for example, SRAM, or other type of volatile memory.", "In certain embodiments, the internal volatile memory 233 may be utilized by the controller 230 for the purpose of caching code and/or data utilized by the one or more processors 232.The memory interface 236 may comprise a physical communication interface for communicating with one or more memory modules external to the controller 230, such as the volatile memory module 250.The volatile memory module 250 may be, for example, DDR DRAM, and may be used as main memory by the controller 230.The volatile memory module 250 may comprise one or more volatile memory chips.", "The controller 230 may be configured to communicate with hardware strap circuitry 240, and obtain therefrom certain configuration data for initializing/configuring the controller 230 and/or one or more components thereof.", "The hardware strap circuitry 240 may comprise straps/pins that are sensed by the controller 230 and latched into data storage registers of the controller.", "The device hardware may use the information in the registers to configure itself, such as by enabling/disabling communication ports, or the like.", "The device of FIG.", "2 may further comprise one or more reset lines 280, which may be communicatively coupled to the one or more processors 232, and allow the system to hold one or more of the processor(s) 232 in reset.", "In certain embodiments, the processor(s) 232 are held in reset until the reset line 280 is released.", "The non-volatile memory 260 may be coupled to the controller 230 over an interface 239, such as a serial peripheral interface bus (SPI) interface.", "In certain embodiments, the non-volatile memory is a NOR boot flash, and may be an 8-pin chip, for example, having both power and data pins.", "On startup, as mentioned above, the controller 230 may first reference data provided by the hardware strap circuitry 240.The controller 230 may then load and execute boot code stored in the internal non-volatile memory 231.In order to execute the code, the processor(s) may be released from reset and enter an active state.", "The controller 230 may then load and execute boot code stored in the internal non-volatile memory 231.Once the boot code has caused the hardware to be initialized in a known state, the controller 230 may be able to communicate with the memory interface 236.For example, the processor(s) 232 may be utilized to initialize the memory interface 239 for communicating with the non-volatile memory 260.The boot code from the internal non-volatile memory 231 may be used to configure the interface 239 (e.g., SPI) for communicating with the non-volatile memory 260.The boot code stored in the internal non-volatile memory 231 may be considered first stage boot loader code.", "According to the boot code loaded from the internal non-volatile memory 231, the controller may be directed to load certain information from the non-volatile memory 260, such as second stage boot loader code and/or initialization parameters for initializing a memory interface 236 of the controller 230.As an alternative, in certain embodiments, all of the boot loader code may be maintained in the internal non-volatile memory 231, as well as the firmware image, such that the non-volatile memory 260 may not be necessary for such purpose.", "The initialization parameters stored in the non-volatile memory 260 may be copied to the internal volatile memory (e.g., SRAM) 233 by the controller 230 and executed therefrom.", "The initialization parameters may provide information for initializing and/or training the memory interface 236 by the processor(s) 232.Once memory interface 236 has been initialized and/or trained, the controller 230 may be configured to load firmware from the non-volatile memory 260, such as a firmware image, to the volatile memory module 250, wherein the volatile memory module 250 provides main memory, or system memory, for the device or system.", "That is, the controller 230 may be configured to execute the firmware stored in volatile memory module 250 in operating the system and/or device.", "Direct Execution of Firmware from External Non-Volatile Memory The various components of the system of FIG.", "2 may individually and/or collectively introduce cost and/or space/design complexity.", "Therefore, it may be desirable to eliminate one or more components from the system to advantageously save cost and/or space.", "Certain embodiments disclosed herein provide a computing or electronic device including a single memory device for both booting and execution.", "Such a solution may allow for the elimination of a specific boot interface, which may save pin count and/or reduce the package size of the controller 230 or other component(s).", "In addition, solutions disclosed herein may allow for reduced hardware and/or software system complexity.", "Furthermore, certain embodiments maintain the programmable interface initialization parameters separate from the boot loader code, which may allow the device to be tailored to the environment for which it is intended.", "FIG.", "3 illustrates a block diagram of a device providing for direct loading and/or execution of firmware and/or boot code from a non-volatile memory module 350 coupled to a controller 330 over a memory interface 336 that requires initialization and/or training for communication therewith.", "The device includes a controller 330 having one or more processors 332 and a memory interface 336 for communicating with a non-volatile memory module 350.Unlike the device of FIG.", "2, in which the controller 230 is coupled to an external volatile memory module 250 over the memory interface 236, the memory module 350 of FIG.", "3 is a non-volatile memory.", "However, similarly to embodiments described above, the non-volatile memory module 350 may comprise DDR memory, and therefore may provide relatively high speed access to data stored therein.", "The non-volatile memory module 350 stores the data in a persistent, rather than a volatile, manner, which may provide certain benefits as described herein.", "The non-volatile memory module 350 may further serve as main memory for the device, which may advantageously result in the device benefitting from non-volatile system memory.", "In certain embodiments, the non-volatile memory module 350 is a direct-attached module mounted (e.g., soldered) to a PCB to which the controller 330 is likewise mounted.", "In certain embodiments, the controller 330 is configured to boot from the non-volatile memory module 350, which is pre-loaded with boot code and firmware for execution by the controller 330; that is, after a power cycle, the first instructions executed by the processor(s) 332 may be from the non-volatile memory 350 (e.g., DDR-attached device).", "The processor(s) 332 may effectively be idle until the memory interface 336 is trained according to one or more methods disclosed herein.", "Once the memory interface 336 is trained, it may be possible for the controller 330 to fetch the first instructions from the non-volatile memory device coupled to the controller 330 over the interface 336.In order to be able to train the memory interface 336 without utilizing the processor(s), it may be necessary for the system to include additional hardware configured to execute said training.", "The device of FIG.", "3 may include hardware strap circuitry 340 and/or reset circuitry 380, as described above in relation to FIG.", "2.Furthermore, the controller 330 of FIG.", "3, may include (1) one or more non-volatile hardware registers 334, which may be configured to store initialization parameter data associated with the memory interface 336, as well as (2) hardware state machine logic 335 configured to read the registers 334 and initialize/train the memory interface 336 using the data stored therein.", "For example, the NVM registers 334 may be programmed with initialization parameters used to initialize/train the memory interface 336, wherein the initialization parameters are loaded into the interface state machine 335.The NVM registers 334 may comprise one or more fuses, which may be used in certain embodiments for the dual purpose of storing the aforementioned initialization parameters data and security signatures for encryption, or other data.", "The registers 334 (e.g., fuses) may advantageously be burned during a manufacturing process.", "In certain embodiments, the registers 334 are one-time programmable devices.", "The registers 334 may therefore have the initialization parameter data and/or other data (e.g., security data) hardcoded therein.", "The NVM registers 334 may further include redundancy copies of at least some of the data stored therein.", "The controller 330 may be configured to read the initialization parameters from the NVM registers 334 while the processor(s) are held in reset.", "Although the registers 334 are described herein as comprising hardware registers, it should be understood that other types of non-volatile storage may be used within the scope of embodiments disclosed herein.", "Because the device hardware substantially autonomously implements the initialization/training of the memory interface 336, it may be unnecessary for the boot code stored in the non-volatile memory module 350 to include memory interface initialization/training code for such purpose.", "On start-up, the hardware strap circuitry 340 may direct the controller 330 to read the initialization parameters from NVM registers 334 into the state machine 335 and use the parameters to perform the training operations.", "The hardware strap data and/or data stored in the NVM registers 334 may further direct the controller to release the processor(s) 332 from reset and jump to the boot code and/or firmware in the non-volatile memory module 350 over the newly-operable memory interface post training (e.g., DDR).", "As shown, the system of FIG.", "3 may leave absent a separate boot flash external to the controller 330, including one or more associated pins.", "Since booting is performed only from the internal hardware and the attached non-volatile memory 350, the boot up process may require fewer stages than other systems, thereby potentially speeding up boot time.", "The state machine circuitry 335 is designed and/or configured to initialize and/or train the memory interface using the initialization parameter data, which may be provided thereto from the one or more NVM registers 334.Therefore, rather than using coded algorithm(s), the controller 330 utilizes a hardware state machine to implement interface initialization/training logic.", "Firmware Execution Processes FIG.", "4 illustrates a process 400 for executing firmware in a computing or electronic device according to one or more embodiments.", "As shown, the process 400 may be executed after a power cycle.", "In one embodiment the process 400 involves first reading bootstrap options at block 402.For example, a state machine in hardware of a computing device may read bootstrap options prior to the relevant processor(s) being released from reset.", "The bootstrap data may direct the controller as to which chip selects are to be activated.", "At block 404, the process 400 involves releasing one or more processors in order to execute initialization/boot code using the processor(s).", "The one or more processors (e.g., microprocessors) may be components of a controller (e.g., SoC).", "The processor(s) may be released at least in part by releasing one or more reset lines coupled to the controller/processor(s).", "In certain embodiments, the process 400 further involves initializing an interface associated with an external boot device (e.g., SPI interface).", "At block 406, the process 400 involves retrieving initialization parameters from non-volatile memory, such as a boot flash module coupled to a controller over a communication interface.", "The processor(s) may determine where to fetch the initialization parameters and/or boot code based on the bootstraps read at block 402.In certain embodiments, the initialization parameters, as well as possibly second stage boot code, are retrieved from an external boot device, such as a SPI flash chip.", "The second stage boot loader image may include the initialization parameters as well as the firmware image for the device.", "The process 400 further involves communicating with a volatile memory module coupled to the controller over a memory interface (e.g., DDR).", "However, in order to communicate with the volatile memory module, it may first be necessary to initialize and/or train the associated memory interface.", "At block 408, the one or more released processors may be used to initialize the interface using the previously-retrieved initialization parameters.", "The interface may further be trained at block 410.Whereas the initialization process may be based on pre-defined configuration starting point data, subsequent training may provide further fine tuning for configuration of the interface.", "The initialization/training blocks (collectively 409) may be performed at least in part by the processor(s), which were previously released from reset.", "For example, such processes may be directed by code stored in internal volatile SRAM memory of the controller.", "Once the interface has been initialized and trained, the process 400 may involve copying firmware from the external non-volatile memory to the volatile memory module at block 412.For example, the firmware may be copied from a NOR flash chip to a DDR memory coupled to the controller through the initialized interface.", "At block 414, the copied firmware may then be executed from the volatile memory module, after which the system or device may be configured to operate under normal operation.", "For example, the processor(s) may jump to the copied firmware in attached DDR memory and execute the code, after which the device may be substantially operational.", "FIG.", "5 provides an illustration of a process 500 for executing firmware in a computing or electronic device according to one or more embodiments, wherein firmware may be executed directly from a non-volatile memory module coupled to a device controller over an interface without the need to first retrieve initialization parameters or data from an external non-volatile memory chip.", "As shown, the process 500 may be executed after a power cycle.", "At block 502, bootstrap option data may be read from bootstrap hardware by hardware of a controller of a computing device, such as a data storage device.", "At block 504, the process 500 involves loading initialization parameters from non-volatile registers of the controller into an interface state machine.", "The interface state machine may comprise hardware configured to execute initialization and/or training operations for initializing and/or training an interface for communication between the controller and a non-volatile memory module coupled to the controller over the interface.", "The bootstrap option data may direct the controller to perform said loading, which may comprise transferring hardware fuse values into the state machine.", "For example, one or more strap options may enable required system interfaces.", "At block 506, the process 500 involves initializing the interface using the initialization parameters and the interface state machine.", "While certain systems and devices may implement interface initialization according to an algorithm run by the system processor(s), in certain embodiments, the interface initialization/training blocks 505 of the process 500 are performed while the system processor(s) are held in reset, and therefore unavailable for such purposes.", "Therefore, in certain embodiments, the steps 505 are implemented at least in part using hardware logic and/or data storage registers of the controller.", "The state machine logic that implements at least part of the blocks 505 may be embedded in the hardware.", "This may require an augmentation to standard controller hardware design to accommodate such functionality.", "Therefore, the communication interface, together with the state machine, may be considered a self-training hardware state machine.", "With further reference to FIG.", "5, as mentioned above, the block 508 involves training the interface.", "In certain embodiments, at least a portion of the operations described with reference to block 504, 506, 508 may be performed without executing firmware by processors of the controller.", "That is, such operations may be performed strictly using hardware devices.", "The interface initialization parameters may be maintained in one or more non-volatile hardware registers of the controller and executed by the state machine.", "Training of the interface may involve any suitable or desirable process.", "For example, training may involve placing certain hardware parameters into appropriate positions within the communication interface.", "In certain embodiments, the process 500 includes a multi-stage training process.", "When a first step of training is completed successfully, as may be indicated by a status update, the process may move on to a next step.", "At block 510, the process 500 may involve releasing the one or more processors of the controller only after the interface has been initialized and/or trained.", "With the one or more processors active, the process 500 may involve executing firmware stored in non-volatile memory connected to the controller over the interface.", "Therefore, according to the process 500 as implemented in a DDR-attached memory solution, state machine logic may provide capability to perform DDR interface training without the need for code execution.", "With the ability to store custom DDR training parameters in the controller hardware, and with hardware state machine logic to perform initialization/training, the first data fetched by the processor(s) after a power cycle may be from a memory device attached to the DDR interface.", "It may be unnecessary to copy code to a DDR-attached memory that is non-volatile and stores code persistently.", "This provides substantial benefit since such copying can take a substantial amount of time in certain systems due to the relatively slow interface commonly associated with external boot devices.", "The inclusion of one-time programmable subset of hardware registers that is used to program the DDR interface may allow for a single non-volatile memory device connected to the external DDR interface of the controller.", "That is, no serial NOR boot flash may need to be present to assist in the boot process.", "Additional Embodiments Those skilled in the art will appreciate that in some embodiments, other types of firmware execution systems can be implemented while remaining within the scope of the present disclosure.", "In addition, the actual steps taken in the processes discussed herein may differ from those described or shown in the figures.", "Depending on the embodiment, certain of the steps described above may be removed, and/or others may be added.", "While certain embodiments have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of protection.", "Indeed, the novel methods and systems described herein may be embodied in a variety of other forms.", "Furthermore, various omissions, substitutions and changes in the form of the methods and systems described herein may be made.", "The accompanying claims and their equivalents are intended to cover such forms or modifications as would fall within the scope and spirit of the protection.", "For example, the various components illustrated in the figures may be implemented as software and/or firmware on a processor, application-specific integrated circuit (ASIC), field-programmable gate array (FPGA), or dedicated hardware.", "Also, the features and attributes of the specific embodiments disclosed above may be combined in different ways to form additional embodiments, all of which fall within the scope of the present disclosure.", "Although the present disclosure provides certain preferred embodiments and applications, other embodiments that are apparent to those of ordinary skill in the art, including embodiments which do not provide all of the features and advantages set forth herein, are also within the scope of this disclosure.", "Accordingly, the scope of the present disclosure is intended to be defined only by reference to the appended claims.", "All of the processes described above may be embodied in, and fully automated via, software code modules executed by one or more general purpose or special purpose computers or processors.", "The code modules may be stored on any type of computer-readable medium or other computer storage device or collection of storage devices.", "Some or all of the methods may alternatively be embodied in specialized computer hardware." ] ]
Patent_15874165
[ [ "BARE FLOOR CLEANER", "A bare floor cleaner has a base and a handle pivotally connected to the base.", "A fluid delivery system of the bare floor cleaner includes a source of cleaning fluid and a fluid distributor in fluid communication with the source of cleaning fluid for dispensing cleaning fluid onto a surface to be cleaned.", "A plurality of support glides are provided on the base to reduce the surface area contact between the base and the surface to be cleaned" ], [ "1.A bare floor cleaner, comprising: a base having a plurality of support glides to reduce the surface area contact between the base and a surface to be cleaned; a handle assembly pivotally connected to the base; a recovery system for collecting dirt; a fluid delivery system comprising a source of cleaning fluid and a fluid distributor in fluid communication with the source of cleaning fluid for dispensing cleaning fluid onto a surface to be cleaned; and a cleaning pad mounted to the base, between the support glides and the surface to be cleaned.", "2.The bare floor cleaner from claim 1, wherein the support glides include a plurality of bristles.", "3.The bare floor cleaner from claim 1, wherein the support glides comprise a retaining portion secured to the base and a support surface that protrudes beneath the base.", "4.The bare floor cleaner from claim 1 and further comprising a plurality of attachment devices located on the base, where in the cleaning pad is wrapped over the support glides and secured to the base via the plurality of pad attachment devices.", "5.The bare floor cleaner from claim 1 and further comprising a plurality of non-skid pads secured to the base, wherein the non-skid pads comprise a support portion that protrudes beneath the base.", "6.A bare floor cleaner, comprising: a base having a plurality of support glides protruding from an underside of the base; a handle assembly pivotally connected to the base; a recovery system comprising a suction nozzle on the base and a motor/fan assembly mounted to one of the handle assembly and the base; a fluid delivery system comprising a source of cleaning fluid and a fluid distributor in fluid communication with the source of cleaning fluid for dispensing cleaning fluid onto a surface to be cleaned; and a cleaning pad mounted to the base and covering the plurality of support glides; wherein the plurality of support glides are indirectly in contact with the surface to be cleaned through the cleaning pad.", "7.The bare floor cleaner from claim 6, wherein the recovery system further comprises a dirt bin assembly.", "8.The bare floor cleaner from claim 7, wherein the dirt bin assembly is removably mounted to the handle assembly.", "9.The bare floor cleaner from claim 6, wherein the suction nozzle is positioned on one side of the base and the fluid distributor is positioned on a different side of the base.", "10.The bare floor cleaner from claim 6, wherein the support glides include a plurality of bristles.", "11.The bare floor cleaner from claim 6, wherein the base comprises a top enclosure mounted to a base platform.", "12.The bare floor cleaner from claim 11, wherein the support glides are secured to the base platform.", "13.The bare floor cleaner from claim 11 and further comprising a plurality of lower pad attachment devices located on a bottom surface of the base platform and a plurality of upper pad attachment devices located on a top surface of the top enclosure, where in the cleaning pad is wrapped over the support glides and secured to the base via the pad attachment devices.", "14.The bare floor cleaner from claim 6, wherein the support glides comprise a retaining portion secured to the base and a support surface that protrudes beneath the base.", "15.The bare floor cleaner from claim 14, wherein the support surface comprises a plurality of support bristles.", "16.The bare floor cleaner from claim 14, wherein the support glides further comprise a deformable retaining wall snaps fit to the base.", "17.The bare floor cleaner from claim 6 and further comprising a plurality of attachment devices located on the base, where in the cleaning pad is wrapped over the support glides and secured to the base via the plurality of pad attachment devices.", "18.The bare floor cleaner from claim 6 and further comprising a plurality of non-skid pads secured to the base, wherein the non-skid pads comprise a support portion that protrudes beneath the base.", "19.The bare floor cleaner from claim 18, wherein the non-skid pads are made of a rubber or elastomeric material.", "20.The bare floor cleaner from claim 6 wherein the source of cleaning fluid comprises a tank mounted to the handle assembly and the fluid distributor is in fluid communication with the tank." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>According to one aspect of the invention, a bare floor cleaner includes a base having a plurality of support glides, a handle assembly pivotally connected to the base, a recovery system, a fluid delivery system comprising a source of cleaning fluid and a fluid distributor in fluid communication with the source of cleaning fluid for dispensing cleaning fluid onto a surface to be cleaned, and a cleaning pad mounted to the base over the support glides." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/843,035, filed Sep. 2, 2015, which is a division of U.S. patent application Ser.", "No.", "11/683,538, filed Mar.", "8, 2007, now U.S. Pat.", "No.", "9,125,540, issued Sep. 8, 2015, which claims the benefit of U.S.", "Provisional Application No.", "60/743,457, filed Mar.", "10, 2006, all of which are incorporated herein by reference in their entirety.", "BACKGROUND OF THE INVENTION Field of the Invention The invention relates to cleaning bare floor surfaces.", "In one aspect, the invention relates to a bare floor cleaner that selectively performs dry vacuuming and wet mopping.", "In another aspect, the invention relates to a bare floor cleaner wherein a dry vacuuming motor is shut off when cleaning solution is deposited on the surface to be cleaned.", "Description of the Related Art The common procedure of cleaning a bare floor surface, such as tile, linoleum, and hardwood floors, involves several steps.", "First, dry or loose dust, dirt, and debris are removed, and then liquid cleaning solution is applied to the surface either directly or by means of an agitator.", "Motion of the agitator with respect to the bare surface acts to loosen the remaining dirt.", "The agitator can be a stationary brush or cloth that is moved by the user, or a motor-driven brush that is moved with respect to a base support by a motor.", "If the agitator is absorbent, it will remove the dirt and collect a portion of the soiled cleaning solution from the floor.", "Cleaning a bare floor commonly requires multiple cleaning tools.", "For example, the first step of removing dry debris most often employs a conventional broom and dustpan.", "A user sweeps dry debris into a pile and then transfers the pile to the dustpan for disposal.", "However, the broom and dustpan are not ideal for removing dry particles because it is difficult to transfer the entire debris pile into the dustpan.", "Additionally, the user typically bends over to hold the dustpan in place while collecting the debris pile.", "Such motion can be inconvenient, difficult, and even painful for some users.", "Dust cloths can also be used, but large dirt particles do not sufficiently adhere thereto.", "Another option is vacuuming the dry debris, but most homes are equipped with vacuum cleaners that are designed for use on carpets and can damage bare surfaces.", "Tools for applying and/or agitating cleaning solution have similar deficiencies.", "The most common cleaning implement for these steps is the traditional sponge or rag mop.", "Mops are capable of loosening dirt from the floor and have excellent absorbency; however, when the mop requires more cleaning solution, it is placed in a bucket to soak up warm cleaning solution and returned to the floor.", "Each time more cleaning solution is required, the mop is usually placed in the same bucket, and after several repetitions the cleaning solution becomes dirty and cold.", "As a result, dirty cleaning solution is used to remove dirt from the bare surface.", "Furthermore, movement of the mop requires physical exertion, and the mop head wears with use and must be replaced periodically.", "Textured cloths can be used as an agitator, but they also require physical exertion and regular replacement.", "Additionally, cloths are not as absorbent as mops and, therefore, can leave more soiled cleaning solution on the floor.", "Some household cleaning devices have been developed to eliminate the need for multiple cleaning implements for cleaning a bare floor and alleviate some of the problems described above that are associated with the individual tools.", "Such cleaning devices are usually adapted for vacuuming or sweeping dry dirt and dust prior to application of cleaning solution, applying and agitating the cleaning solution, and, subsequently, vacuuming the soiled cleaning solution, thereby leaving only a small amount of cleaning solution on the bare surface.", "Common agitators are rotating brushes, rotating mop cloths, and stationary or vibrating sponge mops.", "A good portion of the multifunctional cleaning devices utilize an accessory that is attached to the cleaning device to convert between dry and wet cleaning modes.", "Others are capable of performing all functions without accessories, but have complex designs and features that can be difficult and confusing to operate.", "An example of a dry suctioning and wet mopping floor cleaner is disclosed in U.S. Patent Application Publication No.", "2004/0139572 to Kisela, incorporated herein by reference in its entirety, which discloses a dry suctioning and wet mopping device wherein a solution distributor is affixed to a dry suction nozzle that is rotatable relative to a foot assembly of the device so that the dry suction nozzle can be placed in contact with or away from the surface to be cleaned at the user's discretion.", "Examples of multifunctional bare floor cleaners are disclosed in U.S. Pat.", "Nos.", "2,622,254 and 6,101,668 and in U.S. Patent Application Publication Nos.", "2003/0051301, 2003/0051306, 2003/0051308, 2003/0051309, and 2003/0051310, which are incorporated herein by reference in their entirety.", "The '254 patent discloses an apparatus for cleaning bare and carpeted floors and comprises several independently adjustable cleaning implements, such as a squeegee attached to a suction pipe, a scrubbing roll, and a sweeping roll.", "The apparatus can accomplish wet pickup through the suction pipe, wet scrubbing by means of the scrubbing roll, and dry pickup with a dust collecting nozzle disposed adjacent the sweeping roll.", "The publications listed in the above paragraph are a family of patent applications that disclose a bare floor cleaner having independently adjustable nozzle and brush assemblies.", "The nozzle assembly comprises a single nozzle opening that is surrounded by an overmolded squeegee and through which both wet and dry debris can enter.", "The cleaner operates in a wet pickup mode with the nozzle assembly in contact with the surface to be cleaned.", "The nozzle assembly is raised to a position above the surface to be cleaned for operation in a dry pickup mode.", "The '668 patent is an example of a cleaner that can accomplish all the steps required to clean a bare floor with the assistance of an attachment.", "The cleaner has a cleaning head equipped with a nozzle having squeegees on the front and rear sides thereof and a vertically adjustable scrubbing pad through which cleaning solution can be dispensed.", "When a cover is attached to the bottom of the cleaning head, the entire cleaning head, including the squeegees, nozzle, and scrubbing pad, are raised from the floor to permit dry pickup.", "SUMMARY OF THE INVENTION According to one aspect of the invention, a bare floor cleaner includes a base having a plurality of support glides, a handle assembly pivotally connected to the base, a recovery system, a fluid delivery system comprising a source of cleaning fluid and a fluid distributor in fluid communication with the source of cleaning fluid for dispensing cleaning fluid onto a surface to be cleaned, and a cleaning pad mounted to the base over the support glides.", "BRIEF DESCRIPTION OF THE DRAWINGS In the drawings: FIG.", "1 is a perspective view of a bare floor cleaner according to the invention, comprising a foot assembly and a handle assembly.", "FIG.", "2 is an exploded perspective view of the bare floor cleaner handle assembly shown in FIG.", "1.FIG.", "3 is a partial front view of a lower portion of the handle assembly of the bare floor cleaner shown in FIG.", "1 with a front enclosure removed for clarity.", "FIG.", "4 is a side view of the lower portion of the handle assembly shown in FIG.", "3.FIG.", "5 is an exploded view of a switch assembly of the base floor cleaner.", "FIG.", "6 is a schematic diagram of a solution delivery system of the bare floor cleaner shown in FIG.", "1.FIG.", "7 is an exploded view of the foot assembly of the bare floor cleaner shown in FIG.", "1.FIG.", "8 is a perspective view of a fluid distributor shown in FIG.", "7.FIG.", "9A is a sectional view of a support glide shown in FIG.", "7.FIG.", "9B is a sectional view of an optional pad for the foot assembly.", "FIG.", "10 is a partial view of the handle assembly of the bare floor cleaner of FIG.", "1, illustrated in a dry suction mode configuration.", "FIG.", "11 is a sectional view of the foot assembly of the bare floor cleaner of FIG.", "1, illustrated in the dry suction mode configuration.", "FIG.", "12 is a partial view of the handle assembly of the bare floor cleaner of FIG.", "1, illustrated in a wet mop mode configuration.", "FIG.", "13 is a sectional view of the foot assembly of the bare floor cleaner of FIG.", "1, illustrated in the wet mop mode configuration.", "DESCRIPTION OF THE PREFERRED EMBODIMENT Referring to the drawings and to FIGS.", "1 and 2 in particular, a bare floor cleaner 10 according to the invention comprises a handle assembly 12 pivotally mounted to a base or foot assembly 14.The handle assembly 12 can pivot from an upright or vertical position, where the handle assembly 12 is substantially vertical relative to a surface to be cleaned, to either a first or second lowered position, whereby the handle assembly 12 is respectively moved in an forward or rearward direction relative to the foot assembly 14 and is angled relative to the surface to be cleaned.", "The handle assembly 12 comprises an upper handle assembly 16 and a lower handle assembly 18.The upper handle assembly 16 comprises a hollow handle tube 20 having a grip assembly 22 fixedly attached to a first end of the handle tube 20 and the lower handle assembly 18 fixedly attached to a second end of the handle tube 20 via screws or other suitable commonly known fasteners.", "The grip assembly 22 is essentially an elongated handle shaft that is gripped by the user by wrapping one hand around the shaft; however, it is within the scope of the invention to utilize other grips commonly found on other machines, such as closed-loop grips having circular or triangular shapes.", "The grip assembly 22 comprises a right handle half 21 that mates with a left handle half 23 and provides a user interface to manipulate the bare floor cleaner 10.Additionally, the mating handle halves 21, 23 form a cavity 26 therebetween.", "Referring to FIG.", "2, wherein the right handle half 21 of the grip assembly 22 is removed for illustrative purposes, a trigger 24 is partially mounted within the cavity 26, with a portion of the trigger 24 projecting outwardly from the grip assembly 22 where it is accessible to the user.", "The remainder of the trigger 24 resides in the cavity 26 formed by the handle halves 21, 23 and communicates with a push rod 25 that is positioned within the hollow interior of the handle tube 20.The trigger 24 is pivotally mounted to the handle halves 21, 23 so that the trigger 24 can rotate relative to the grip assembly 22 in a conventional manner.", "The lower handle 18 comprises a generally elongated rear enclosure 28 that provides structural support for components of the bare floor cleaner 10 contained therein.", "A front enclosure 29 mates with the rear enclosure 28 to form a central cavity 36 therebetween.", "A first recess 32 is formed above the rear enclosure 28 and a second recess 34 is formed below the front enclosure 29.A lower end of the lower handle assembly 18 comprises a generally rectangular conduit 31 that defines a working air inlet to the handle assembly 12 and is in fluid communication with the foot assembly 14.A dirt bin assembly 50 is removably mounted in the second recess 34.The dirt bin assembly is preferably constructed, at least partially, of a translucent material.", "A suitable dirt bin assembly is more fully described in PCT Application No.", "PCT/US2004/026952, which is incorporated herein by reference in its entirety.", "The dirt bin assembly 50 is in fluid communication with the conduit 31 when it is mounted in the second recess 34 such that working air from the foot assembly 14 is drawn through the dirt bin assembly 50 by a motor/fan assembly 33.Dry debris entrained in the working air will be separated and collected by the dirt bin assembly 50.The motor/fan assembly 33 is mounted in the cavity 36, and is vertically located between the first recess 32 and the second recess 34.The motor/fan assembly 33 creates airflow in a conventional manner, which moves debris from the surface being cleaned into the cleaner 10.The motor/fan assembly 33 is powered by a commonly known rechargeable battery pack 37 that is also located within the cavity 36.The battery pack 37 is selectively connected to the motor/fan assembly 33 through an electrical on/off switch 38 operable through a switch aperture 39 in the front enclosure 29 via a switch button 41.Alternatively, the motor/fan assembly 33 can be mounted to the foot assembly 14 in a commonly known fashion.", "Referring to FIGS.", "3 and 4, the lower handle assembly 18 further comprises a transfer rod 52 that is slidably secured therein via a pair of cutouts 54 surrounding corresponding screw bosses that partially secure the rear enclosure 28 to the front enclosure 29.A solution valve assembly 56 is fixedly mounted in spaced relation to a valve assembly engagement surface 58 on one end of the transfer rod 52.A trigger stop pivot 60, located adjacent to the cutouts 54, extends from a side surface of the transfer rod 52 and pivotally mounts a trigger stop 62 on a pin 63 extending therefrom.", "A mechanical stop 64 is located on the trigger stop pivot 60 to limit rotational movement of the trigger stop 62.A stop rib 66 is integrally formed on the rear enclosure 28 in close proximity to one end of the trigger stop 62.A resilient spring arm 72 protrudes from a side surface of the transfer rod 52, and the free end of the spring arm 72 engages with a corresponding spring support 74 integrally formed in the rear enclosure 28.The spring support 74 can further be a screw boss used to secure the rear enclosure 28 to the front enclosure 29.The trigger stop 62 further comprises a bearing surface 68 that rotates about the pin 63 as well as a stop rib engagement surface 70 that makes selective contact with the stop rib 66 depending upon the orientation of the handle assembly 12 relative to foot assembly 14 as will be discussed in more detailed herein.", "Referring to FIGS.", "4 and 5, a rigid switch interface arm 76 extends orthogonally from a front face of the transfer rod 52 and selectively engages an upper surface of the switch button 41.The switch button 41 further comprises a pair of switch button bosses 80 to which the on/off switch 38 is attached by a pair of screws 81.Specifically, the on/off switch 38 comprises a commonly known switch body 85 containing a slideable switch actuator 84 that can be moved by the user to open or close the electrical circuit.", "The switch body 85 is fixedly attached to the bosses 80 of the switch button 41 for movement therewith.", "This configuration holds the switch actuator 84 stationary while the switch body 85 is moved.", "The switch button 41 therefore controls the position of the switch actuator 84 since the switch button 41 is directly coupled to the switch body 85.The switch interface arm 76 is dimensioned so that a portion overlaps the upper switch button boss 80.A switch bridge 82 is rigidly attached to an inside surface of the front enclosure 29 via a pair of screws 83A received in screw bosses 83B.", "The switch bridge 82 further comprises a generally central aperture 96 that receives the switch actuator 84.Referring to FIGS.", "2 and 6, a solution tank assembly 40 is removably mounted to the lower handle 18 such that it partially rests on the rear enclosure 28 and is partially received by the first recess 32.The solution tank assembly 40 comprises a tank to hold a predetermined amount of cleaning solution which comprises a liquid, such as water, cleaning detergent, or a mixture thereof.", "As shown schematically in FIG.", "6, when the solution tank assembly 40 is mounted to the lower handle 18, it is in fluid communication with a commonly known receiver 43.A first solution conduit 42 fluidly communicates between the receiver 43 and a solution valve assembly 56.A second solution conduit 35 fluidly communicates between an outlet of the solution valve assembly 56 and a solution tee 44 located in the foot assembly 14 as will be described in more detail below.", "Each of a pair of distribution conduits 67 fluidly communicates between the solution tee 44 and a corresponding pair of solution distributors 112.Optionally, a heating element 90 can be provided between the solution valve assembly 56 and the fluid distributors 112 to heat the cleaning solution prior to distribution onto the surface to be cleaned as is more fully disclosed in U.S. Pat.", "No.", "6,131,237 which is incorporated herein by reference in its entirety.", "The heating element 90 can be powered through the battery pack 37 in a commonly known manner.", "A suitable solution tank assembly and fluid distribution system is more fully described in the above referenced '952 PCT application.", "Referring to FIG.", "7, the foot assembly 14 comprises a top enclosure 86 mounted to a base platform 88 to define therebetween a cavity that houses several components of the foot assembly 14.The base platform 88 provides structural support for several of the foot assembly components, including a handle pivot 98, the solution distributors 112, solution conduits 67, solution tee 44, a plurality of support glides 46, a plurality of lower pad attachment devices 47, and a pair of upper pad attachment devices 48.The base platform 88 also forms an integral dry suction nozzle 92 near one edge thereof.", "The handle pivot 98 pivotally mounts the handle assembly 12 to the foot assembly 14 and comprises a barrel 100 with a longitudinal inlet aperture 102 formed in a sidewall thereof to create a working air path from the dry suction nozzle 92 to the dirt bin assembly 50 through a conduit 104 that is integrally formed with the barrel 100.The conduit 104 is in fluid communication with conduit 31 and can be at least partially received within conduit 31.A suitable handle pivot is more fully described in the above referenced '952 PCT application.", "A working air passage 106 is substantially integrally formed between the dry suction nozzle 92 and the handle pivot 98.However, to simplify the manufacturing process, the base platform 88 can also accept individual pieces such as a working air cap 110 to complete the working air passage 106.One advantage of incorporating removable parts into the working air path is that access can be gained to the air path for cleaning out occasional clogs.", "Referring to FIG.", "8, the solution distributors 112 each comprise a hollow body 114 mated to an outlet manifold 116.The hollow body 114 further comprises a conduit barb 118 to fluidly communicate with the aforementioned solution conduits 67.The outlet manifold 116 further comprises a plurality of orifices 122 to deliver solution to the surface to be cleaned.", "The orifices 122 can be angled relative to each other so that fluid distribution can be spread in any desired pattern, such as a fan-shaped pattern.", "A solution conduit 67 is attached to the conduit barb 118 on one end.", "The other end of the solution conduit 67 is attached to a conduit barb on the solution tee 44, placing the solution distributors 112 and the solution tee 44 in fluid communication.", "The solution distributors 112 are securely positioned in corresponding recesses 113 in the base platform 88 by a mounting feature 120 that extends from the hollow body 114, and are oriented on a side of the foot assembly 14 opposite the dry suction nozzle 92.Referring to FIG.", "9A, the support glides 46 are secured to the base platform 88 and comprise a retaining portion 124, a retaining wall 126, and a support surface 128.The support surface 128 can comprise a plurality of support bristles.", "The retaining portion 124 is secured to the base platform 88 by pushing the retaining portion 124 through a corresponding aperture in the base platform 88 so that the retaining wall 126 deforms as it passes through the aperture and snaps into place.", "The support surface 128 protrudes beneath the base platform 88 so that the weight of the bare floor cleaner 10 is supported solely through the support glides 46.This minimizes the surface area contact between the bare floor cleaner 10 and the surface to be cleaned, resulting in lower frictional forces and easing the push force required to be supplied by the user as the foot assembly 14 is moved across the surface to be cleaned.", "Referring to FIG.", "7, the lower pad attachment devices 47 are located on a bottom surface of the base platform 88 and the upper pad attachment devices 48 are located on a top surface of the top enclosure 86.The attachment devices 47, 48 are preferably made of the hook portion of a commonly known hook and loop fastener material, such as Velcro®, and are secured to the base platform 88 and top enclosure 86 with adhesive.", "A mop cloth 130 is wrapped over the support glides 46 (FIG.", "9) and secured to the foot assembly 14 via the pad attachment devices 47, 48.Referring to FIG.", "9B, optional non-skid pads 132 can be secured to the base platform 88 in place of or in addition to the support glides 46 to achieve a different result.", "The pads 132 comprise a retaining portion 134 and a support portion 136.The retaining portion 134 has a retaining wall 138 and is secured to the base platform 88 by pushing the retaining portion 134 through a corresponding aperture in the base platform 88 so that the retaining wall 138 deforms as it passes through the aperture and snaps into place.", "The support portion 136 protrudes beneath the base platform 88 so that the weight of the bare floor cleaner 10 is supported solely through the non-skid pads 132.The non-skid pads 132 are typically made of a rubber or elastomeric material that has a high coefficient of friction and provide a high friction surface area contact between the bare floor cleaner 10 and the surface to be cleaned, increasing the push force required to be supplied by the user as the foot assembly 14 is moved across the surface to be cleaned.", "The non-skid pads 132 discourage use of the bare floor cleaner 10 when no mop cloth 130 is present, thus minimizing the possibility of the bare foot assembly 14 causing damage to the surface to be cleaned.", "The bare floor cleaner 10 can be selectively operated in a dry suction mode, in which dry dirt and debris from the surface to be cleaned is collected in the dirt bin assembly 50 via the dry suction nozzle 92, or a wet mopping mode, in which solution is distributed onto the surface to be cleaned from the solution distributors 112 and scrubbed using the mop cloth 130.Referring to FIGS.", "10 and 11, the dry suction mode is described wherein the handle assembly 12 is in a first lowered position, in which the handle assembly 12 is generally oriented over the solution distributors 112 such that the dry nozzle assembly 92 is positioned ahead of the handle assembly 12 relative to the solution distributors 112.In this position, the trigger 24 is oriented on an upper portion of the grip assembly 22 and out of convenient reach of the user.", "The inlet aperture 102 of the handle pivot 98 is aligned with an aperture 109 in a pivot cradle 108 formed in the base platform 88.As a result, a working air path extends from the dry nozzle assembly 92, through space 115 between the base platform 88 and the working air cap 110, through the conduit 104 that projects from the pivot barrel 100, and through conduit 31 to an inlet of the dirt bin assembly 50.A suitable air path is more fully described in the above referenced '952 PCT application The motor/fan assembly 33 can be activated and de-activated by the user via the switch button 41.The switch button 41 position, and hence whether the motor/fan assembly 33 is activated or deactivated, can be changed by the user regardless of the handle orientation.", "No solution is intended to be distributed during dry suction mode.", "As previously mentioned, the trigger 24 is out of convenient reach of the user to minimize activation.", "Furthermore, with the handle assembly 12 in the first lowered position, the trigger stop 62 rotates about the pin 63 under force of gravity and comes to rest on the inside wall of the rear enclosure 28 in close proximity to the trigger stop rib 66.Therefore, even if the trigger 24 is inadvertently engaged by the user, the trigger stop 62 prevents the transfer rod 52 from moving.", "Referring now to FIGS.", "12 and 13, a wet mop mode is described wherein the handle assembly 12 is in a second lowered position, in which the handle assembly is generally oriented over the dry nozzle assembly 92 such that the solution distributors 112 are positioned ahead of the dry nozzle assembly 92 relative to the handle assembly 12.When the handle assembly 12 is in the second lowered position, the barrel 100 blocks the aperture 109 and no air is drawn into the dirt bin assembly 50.When the handle assembly 12 is in second lowered position, the trigger 24 is on an underside of the grip assembly 22 and within convenient reach of the user.", "Referring to FIG.", "12 and the schematic in FIG.", "6, cleaning solution can be selectively dispensed from the solution tank assembly 40 via depression of the trigger 24, which engages the push rod 25.As the push rod 25 moves, an engagement surface 77 on one end of the push rod 25 contacts a push rod engagement surface 78 on the transfer rod 52.Since the handle assembly 12 is inclined, the trigger stop 62 falls, under the force of gravity, away from the stop rib 66 and comes to rest on the mechanical stop 64 on the transfer rod 52.With the trigger stop 62 in this position, the transfer rod 52 can move in response to the force from the push rod 25, whereby the solution valve assembly engagement surface 58 contacts a transfer rod engagement surface 71 on the solution valve assembly 56, thus opening the solution valve assembly 56.Subsequently, cleaning solution flows by gravitational feed from the solution tank assembly 40 sequentially through the receiver 43, through the solution conduit 42, through the now open solution valve assembly 56, through the second solution conduit 35, through the solution tee 44, through the distribution conduits 67, and finally to the fluid distributors 112, where cleaning solution is dispensed in the desired pattern onto the surface to be cleaned.", "Referring to FIGS.", "5, 12, and 13, movement of the transfer rod 52 further causes the spring arm 72 to deflect against the spring support 74, creating an opposing force to the trigger 24 and tending to return the transfer rod 52 to an at rest position.", "Additionally, as the transfer rod 52 moves, the switch interface arm 76 contacts the upper switch button boss 80 forcing the switch button 41 and switch body 85 down.", "As the switch body 85 moves down, the switch actuator 84 is held stationary by the switch bridge 82, thus moving the on/off switch from an “on” position to an “off” position.", "Therefore, with the cleaner 10 in the wet mop mode, cleaning solution can be applied to the surface to be cleaned and the motor/fan assembly 33 is automatically turned off.", "It is desirable to turn off the motor/fan assembly 33 during the wet mode because the dirt bin assembly 50 of the cleaner 10 is not designed to perform wet extraction and the battery life of the cleaner 10 can be extended.", "When the trigger 24 is released, the spring arm 72 biases the transfer rod 52 back to the normal position, a spring 94 on the solution valve assembly 56 closes the solution valve assembly 56 and the flow of cleaning solution from the solution tank assembly 40 is stopped.", "The user can then move the foot assembly 14 over the dispensed cleaning solution and use the mop cloth 130 to agitate debris on the surface and absorb excess cleaning solution.", "The motor/fan assembly 33 remains deactivated and will remain so until the user manually actuates the switch button 41.Since the weight of the bare floor cleaner 10 is fully supported by the support glides 46, surface contact between the bare floor cleaner 10 and the surface to be cleaned is minimized and friction is reduced, resulting in a low push force required to manipulate the bare floor cleaner 10.Since the support glides 46 are always indirectly in contact with the surface to be cleaned through the mop cloth 130, lower push forces are encountered in both the wet mop and dry suction modes.", "While the invention has been specifically described in connection with certain specific embodiments thereof, it is to be understood that this is by way of illustration and not of limitation.", "Reasonable variation and combination are possible with the scope of the foregoing disclosure without departing from the spirit of the invention, which is defined in the appended claims." ] ]
Patent_15874166
[ [ "Cellulosic Arabinoxylan fiber (CAF) and Methods of Preparing", "Processes for the preparation of cellulosic arabinoxylan fiber.", "Cellulosic arabinoxylan fiber prepared by the processes.", "Edible formulations, containing the cellulose arabinoxylan fiber, wherein the cellulosic arabinoxylan fiber function as bulking agents in the edible formulation.", "Methods of stabilizing an emulsion, involving mixing an effective stabilizing amount of the cellulosic arabinoxylan fiber with an emulsion to stabilize said emulsion.", "Methods of increasing the water holding capacity of a composition, involving mixing an effective water holding increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the water holding capacity of said composition.", "Method of increasing the bulk of a composition, involving mixing an effective bulk increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the water holding capacity of said composition.", "Methods of increasing the viscosity of a composition, involving mixing an effective viscosity increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the viscosity of said composition." ], [ "1.A process for the preparation of cellulosic arabinoxylan fiber comprising: (a) mixing ground agricultural materials in water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension, (b) adjusting the pH of said suspension to about 11.5, (c) subjecting said suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (d) mixing said solid residue with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension.", "(e) subjecting said suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (f) mixing said solid residue from (e) with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, (g) subjecting said suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (h) mixing said solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (i) subjecting said suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (j) mixing said solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension and subjecting said suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, and (k) repeating step (j) until a clear supernatant is obtained-and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried cellulosic arabinoxylan fiber.", "2.The process according to claim 1, comprising: (a) mixing ground agricultural materials in water at about 85° C. to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension and stirring about 1 hour, (b) adjusting the pH of said suspension to about 11.5 and stirring said suspension for about 30 minutes, (c) subjecting said suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (d) mixing said solid residue with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (e) subjecting said suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (f) mixing said solid residue from (e) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (g) subjecting said suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (h) mixing said solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (i) subjecting said suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (j) mixing said solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension and subjecting said suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, and (k) repeating step (j) until a clear supernatant is obtained and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried cellulosic arabinoxylan fiber.", "3.The method according to claim 1, wherein said drying in (k) is spray drying or drum drying.", "4.Dried alkali-insoluble cellulosic arabinoxylan fiber prepared by a process comprising: (a) mixing ground agricultural materials in water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension, (b) adjusting the pH of said suspension to about 11.5, (c) subjecting said suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (d) mixing said solid residue with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, (e) subjecting said suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (f) mixing said solid residue from (e) with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, (g) subjecting said suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (h) mixing said solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (i) subjecting said suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (j) mixing said solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension and subjecting said suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, and (k) repeating step (j) until a clear supernatant is obtained and separating said supernatant from said solid residue and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried alkali-insoluble cellulosic arabinoxylan fiber; wherein said process does not involve the use of hydrogen peroxide.", "5.An edible formulation, comprising the cellulosic arabinoxylan fiber prepared by claim 1, wherein said cellulosic arabinoxylan fiber functions as bulking agents in the edible formulation.", "6.A method of stabilizing an emulsion, comprising mixing an effective stabilizing amount of the cellulosic arabinoxylan fiber produced by the process according to claim 1 with an emulsion to stabilize said emulsion.", "7.A method of increasing the water holding capacity of a composition, comprising mixing an effective water holding increasing amount of the cellulosic arabinoxylan fiber produced by the process according to claim 1 with a composition to increase the water holding capacity of said composition.", "8.A method of increasing the bulk of a composition, comprising mixing an effective bulk increasing amount of the cellulosic arabinoxylan fiber produced by the process according to claim 1 with a composition to increase the water holding capacity of said composition.", "9.A method of increasing the viscosity of a composition, comprising mixing an effective viscosity increasing amount of the cellulosic arabinoxylan fiber produced by the process according to claim 1 with a composition to increase the viscosity of said composition.", "10.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said process comprises: (a) mixing ground agricultural materials in water at about 85° C. to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension and stirring about 1 hour, (b) adjusting the pH of said suspension to about 11.5 and stirring said suspension for about 30 minutes, (c) subjecting said suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (d) mixing said solid residue with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (e) subjecting said suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (f) mixing said solid residue from (e) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (g) subjecting said suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (h) mixing said solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (i) subjecting said suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (j) mixing said solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension and subjecting said suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, and (k) repeating step (j) until a clear supernatant is obtained and separating said supernatant from said solid residue and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried alkali-insoluble cellulosic arabinoxylan fiber; wherein said process does not involve the use of hydrogen peroxide.", "11.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said ground agricultural materials is corn bran and wherein said dried alkali-insoluble cellulosic arabinoxylan fiber has a water holding capacity of at least 31.795 grams per gram of said dried alkali-insoluble cellulosic arabinoxylan fiber.", "12.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said ground agricultural materials is com bran and wherein said dried alkali-insoluble cellulosic arabinoxylan fiber has a oxygen radical absorbance capacity of at least 868 μmole Trolox/100 grams of said dried alkali-insoluble cellulosic arabinoxylan fiber.", "13.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said process consists essentially of: (a) mixing ground agricultural materials in water at about 85° C. to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension and stirring about 1 hour, (b) adjusting the pH of said suspension to about 11.5 and stirring said suspension for about 30 minutes, (c) subjecting said suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant, from said solid residue, (d) mixing said solid residue with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (e) subjecting said suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (f) mixing said solid residue from (e) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (g) subjecting said suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (h) mixing said solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (i) subjecting said suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (j) mixing said solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension and subjecting said suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, and (k) repeating step (j) until a clear supernatant is obtained and separating said supernatant from said solid residue and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried alkali-insoluble cellulosic arabinoxylan fiber; wherein said process does not involve the use of hydrogen peroxide.", "14.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said process consists of: (a) mixing ground agricultural materials in water at about 85° C. to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension and stirring about 1 hour, (h) adjusting the pH of said suspension to about 11.5 and stirring said suspension for about 30 minutes, (c) subjecting said suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue and separating said supernatant from said solid residue, (d) mixing said solid residue with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (e) subjecting said suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (f) mixing said solid residue from (e) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (g) subjecting said suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (h) mixing said solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (i) subjecting said suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (j) mixing said solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension and subjecting said suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, and (k) repeating step (j) until a clear supernatant is obtained and separating said supernatant from said solid residue and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried alkali-insoluble cellulosic arabinoxylan fiber; wherein said process does not involve the use of hydrogen peroxide.", "15.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said process does not involve the use of an oxidizing agent.", "16.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said dried alkali-insoluble cellulosic arabinoxylan fiber contains at least 11.69 wt % xylose.", "17.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said dried alkali-insoluble cellulosic arabinoxylan fiber contains at least 1.70 wt % arabinose.", "18.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said dried alkali-insoluble cellulosic arabinoxylan fiber contains xylose and arabinose in the form of branched, arabinoxylan with a β-1,4 linked xylan backbone.", "19.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said dried alkali-insoluble cellulosic arabinoxylan fiber is an antioxidant and has an oxygen radical absorbance capacity value of at least 326 μmole Trolox/100 g dried alkali-insoluble cellulosic arabinoxylan fiber.", "20.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said ground agricultural materials are corn bran, wherein said dried alkali-insoluble cellulosic arabinoxylan fiber is an antioxidant and has an oxygen radical absorbance capacity value of at least 868 μmole Trolox/100 g dried alkali-insoluble cellulosic arabinoxylan fiber.", "21.The dried alkali-insoluble cellulosic arabinoxylan fiber of claim 4, wherein said ground agricultural materials is corn bran and wherein said dried alkali-insoluble cellulosic arabinoxylan fiber in water has a viscosity of at least 10.45 Pa.s.", "22.An alkali-insoluble dietary fiber comprising glucose, xylose and arabinose, wherein said xylose and arabinose are present in the form of branched arabinoxylan with a β-1,4 linked xylan backbone.", "23.The substantially alkali-insoluble dietary fiber of claim 22 devoid of alkali-soluble dietary fiber.", "24.The alkali-insoluble dietary fiber of claim 22 in a spray-dried form.", "25.The alkali-insoluble dietary fiber of claim 22 having an antioxidant capacity.", "26.The alkali-insoluble dietary fiber of claim 22 having an antioxidant capacity due to the presence of phenolic compounds.", "27.The alkali-insoluble dietary fiber of claim 22 haying an antioxidant capacity, wherein said alkali-insoluble dietary fiber has an oxygen radical absorbance capacity value of at least 326 μmole Trolox/100 g substantially insoluble dietary fiber.", "28.The alkali-insoluble dietary fiber of claim 22 prepared by a process comprising: (a) mixing ground agricultural materials in water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension, (b) adjusting the pH of said suspension to about 11.5, (c) subjecting said suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (d) mixing said solid residue with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, (e) subjecting said suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (f) mixing said solid residue from (e) with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, (g) subjecting said suspension, from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (h) mixing said solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (i) subjecting said suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, (j) mixing said solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stilling for about 5 minutes to form a suspension and subjecting said suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue and separating said supernatant from said solid residue, and (k) repeating step (j) until a clear supernatant is obtained and separating said supernatant from said solid residue and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried alkali-insoluble cellulosic arabinoxylan fiber; wherein said process does not involve the use of hydrogen peroxide.", "29.The alkali-insoluble dietary fiber of claim 28 wherein said ground agricultural materials are corn bran, wherein said dried alkali-insoluble cellulosic arabinoxylan fiber is an antioxidant and has an oxygen radical absorbance capacity value of at least 868 μmole Trolox/100 g dried alkali-insoluble cellulosic arabinoxylan fiber." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Processes for the preparation of cellulosic arabinoxylan fiber involving: (a) mixing ground agricultural materials in water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension, (b) adjusting the pH of the suspension to about 11.5, (c) subjecting the suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (d) mixing the solid residue with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension.", "(e) subjecting the suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue.", "(f) mixing the solid residue from (e) with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, (g) subjecting the suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling the suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (h) mixing the solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes 10 form a suspension, (i) subjecting the suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting the suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (j) mixing the solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension and subjecting the suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting the suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling the suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, and (k) repeating step (j) until a clear supernatant is obtained and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried cellulosic arabinoxylan fiber.", "Agricultural processing byproducts (e.g., sorghum bran, corn bran, corn fiber, rice fiber, rice hulls, pea fiber, barley hulls, oat hulls, soybean bulls, sugar cane bagasse, sugar-beet bagasse, carrot pomace etc.)", "contain numerous components that could be valuable co-products if they could be economically isolated.", "Agricultural residues (e.g., corn stover, wheat straw, rice straw, barley straw etc.,) and energy crops (e.g., sorghum bagasse, biomass sorghum, switchgrass, Miscanthus, etc.)", "may also be abundant and inexpensive sources for many valuable coproducts.", "Such Lignocellulosic materials rich in lignocellulose are abundant and renewable biological resources.", "These lignocellulosic materials are natural composites consisting of three main polymeric components: cellulose, hemicellulose, and lignin, as well as other minor components such as extractives (e.g., phenolics, lipids, etc.", "), pectin, or protein (Zhang, Y.-H. P., and L. R. Lynd, Biotechnol.", "Bioeng., 88; 797-824 (2004); Fengel, D., and G. Wegener, Wood: Chemistry, Ultrastructure, Reactions; Walter de Gruyter & Co., Berlin, 1984).", "Lignocellulosic byproducts are the source of many valuable bio-based products, which can be used in several industries.", "Fibers from lignocellulosic sources have various applications, such as building materials, particle board, human food, animal feed, cosmetics, medicine and many others (Reddy, N., and Y. Yang, Trends in Biotechnology, 23: 22-27 (2005)).", "It is becoming important to develop consumer products from the above mentioned renewable resources.", "The isolation of cellulose suitable for human consumption from agricultural processing byproducts (e.g., soy hulls, sugar beet pulps, pea hulls, corn bran, etc.)", "has been reported (U.S. Pat.", "No.", "4,486,459; U.S. Pat.", "No.", "5,057,334).", "Corn fiber/bran, a renewable resource available in huge quantities, can be a good source of valuable consumer products.", "Corn fiber makes up about 5 to 10 wt.", "% portion of the total weight of corn kernel.", "It is made up of a number of valuable components, which if extracted economically can be commercially valuable.", "Corn fiber consists primarily of residual starch (10 to 20 wt.", "%), hemicelluloses (40 to 50 wt.", "%), cellulose (15 to 25 wt.", "%), phenolic compounds (3 to 5 wt.", "%), protein (5 to 10 wt %), and some oils (Wolf, M. J., et al., Cereal Chemistry, 30, 451-470 (1953); Chanliaud, E., et al., J. Cereal Science, 21:195-203 (1995)).", "The variations in the fiber composition are believed to be due to corn plant variety and growth conditions as well as isolation methods used.", "After removing the commercially valuable component “hemicelluloses” from, for example, corn fiber, the insoluble residue can be isolated, purified and its functionalities can be tested for commercial uses.", "Based on our studies, this residue, called “cellulosic arabinoxylan fiber” (CAF), has a unique water holding capacity and could be used, for example, as a food bulking agent and thickener." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Processes for the preparation of cellulosic arabinoxylan fiber involving (a) mixing ground agricultural materials in water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension; (b) adjusting the pH of the suspension to about 11.5; (c) subjecting the suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue; (d) mixing the solid residue with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension; (e) subjecting the suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue; (f) mixing the solid residue from (e) with water at temperatures in the range of about 75°C.", "to about 100° C. to form a suspension; (g) subjecting the suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling the suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue; (h) mixing the solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension; (i) subjecting the suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting the suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue; (j) mixing the solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension and subjecting the suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting the suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling the suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue; and (k) repeating step (j) until a clear supernatant is obtained and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried cellulosic arabinoxylan fiber.", "Cellulosic arabinoxylan fiber prepared by the processes.", "Edible formulations, containing the cellulosic arabinoxylan fiber, wherein the cellulosic arabinoxylan fiber functions as bulking agents in the edible formulation.", "Methods of stabilizing an emulsion, involving mixing an effective stabilizing amount of the cellulosic arabinoxylan fiber with an emulsion to stabilize said emulsion.", "Methods of increasing the water holding capacity of a composition, involving mixing an effective water holding increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the water holding capacity of said composition.", "Method of increasing the bulk of a composition, involving mixing an effective bulk increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the water holding capacity of said composition.", "Methods of increasing the viscosity of a composition, involving mixing an effective viscosity increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the viscosity of said composition.", "This summary is provided to introduce a selection of concepts in a simplified form that are further described below in the detailed description.", "This summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended as an aid in determining the scope of the claimed subject matter." ], [ "REFERENCE TO RELATED APPLICATION This application claims the benefit of U.S.", "Provisional Application No.", "62/016,224, filed 24 Jun.", "2014, which is incorporated herein by reference in its entirety.", "BACKGROUND OF THE INVENTION Processes for the preparation of cellulosic arabinoxylan fiber involving: (a) mixing ground agricultural materials in water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension, (b) adjusting the pH of the suspension to about 11.5, (c) subjecting the suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (d) mixing the solid residue with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension.", "(e) subjecting the suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue.", "(f) mixing the solid residue from (e) with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, (g) subjecting the suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling the suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (h) mixing the solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes 10 form a suspension, (i) subjecting the suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting the suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (j) mixing the solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension and subjecting the suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting the suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling the suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, and (k) repeating step (j) until a clear supernatant is obtained and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried cellulosic arabinoxylan fiber.", "Agricultural processing byproducts (e.g., sorghum bran, corn bran, corn fiber, rice fiber, rice hulls, pea fiber, barley hulls, oat hulls, soybean bulls, sugar cane bagasse, sugar-beet bagasse, carrot pomace etc.)", "contain numerous components that could be valuable co-products if they could be economically isolated.", "Agricultural residues (e.g., corn stover, wheat straw, rice straw, barley straw etc.,) and energy crops (e.g., sorghum bagasse, biomass sorghum, switchgrass, Miscanthus, etc.)", "may also be abundant and inexpensive sources for many valuable coproducts.", "Such Lignocellulosic materials rich in lignocellulose are abundant and renewable biological resources.", "These lignocellulosic materials are natural composites consisting of three main polymeric components: cellulose, hemicellulose, and lignin, as well as other minor components such as extractives (e.g., phenolics, lipids, etc.", "), pectin, or protein (Zhang, Y.-H. P., and L. R. Lynd, Biotechnol.", "Bioeng., 88; 797-824 (2004); Fengel, D., and G. Wegener, Wood: Chemistry, Ultrastructure, Reactions; Walter de Gruyter & Co., Berlin, 1984).", "Lignocellulosic byproducts are the source of many valuable bio-based products, which can be used in several industries.", "Fibers from lignocellulosic sources have various applications, such as building materials, particle board, human food, animal feed, cosmetics, medicine and many others (Reddy, N., and Y. Yang, Trends in Biotechnology, 23: 22-27 (2005)).", "It is becoming important to develop consumer products from the above mentioned renewable resources.", "The isolation of cellulose suitable for human consumption from agricultural processing byproducts (e.g., soy hulls, sugar beet pulps, pea hulls, corn bran, etc.)", "has been reported (U.S. Pat.", "No.", "4,486,459; U.S. Pat.", "No.", "5,057,334).", "Corn fiber/bran, a renewable resource available in huge quantities, can be a good source of valuable consumer products.", "Corn fiber makes up about 5 to 10 wt.", "% portion of the total weight of corn kernel.", "It is made up of a number of valuable components, which if extracted economically can be commercially valuable.", "Corn fiber consists primarily of residual starch (10 to 20 wt.", "%), hemicelluloses (40 to 50 wt.", "%), cellulose (15 to 25 wt.", "%), phenolic compounds (3 to 5 wt.", "%), protein (5 to 10 wt %), and some oils (Wolf, M. J., et al., Cereal Chemistry, 30, 451-470 (1953); Chanliaud, E., et al., J. Cereal Science, 21:195-203 (1995)).", "The variations in the fiber composition are believed to be due to corn plant variety and growth conditions as well as isolation methods used.", "After removing the commercially valuable component “hemicelluloses” from, for example, corn fiber, the insoluble residue can be isolated, purified and its functionalities can be tested for commercial uses.", "Based on our studies, this residue, called “cellulosic arabinoxylan fiber” (CAF), has a unique water holding capacity and could be used, for example, as a food bulking agent and thickener.", "SUMMARY OF THE INVENTION Processes for the preparation of cellulosic arabinoxylan fiber involving (a) mixing ground agricultural materials in water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension; (b) adjusting the pH of the suspension to about 11.5; (c) subjecting the suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue; (d) mixing the solid residue with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension; (e) subjecting the suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue; (f) mixing the solid residue from (e) with water at temperatures in the range of about 75°C.", "to about 100° C. to form a suspension; (g) subjecting the suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling the suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue; (h) mixing the solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension; (i) subjecting the suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting the suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue; (j) mixing the solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension and subjecting the suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting the suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling the suspension to about room temperature and centrifuging the suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue; and (k) repeating step (j) until a clear supernatant is obtained and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried cellulosic arabinoxylan fiber.", "Cellulosic arabinoxylan fiber prepared by the processes.", "Edible formulations, containing the cellulosic arabinoxylan fiber, wherein the cellulosic arabinoxylan fiber functions as bulking agents in the edible formulation.", "Methods of stabilizing an emulsion, involving mixing an effective stabilizing amount of the cellulosic arabinoxylan fiber with an emulsion to stabilize said emulsion.", "Methods of increasing the water holding capacity of a composition, involving mixing an effective water holding increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the water holding capacity of said composition.", "Method of increasing the bulk of a composition, involving mixing an effective bulk increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the water holding capacity of said composition.", "Methods of increasing the viscosity of a composition, involving mixing an effective viscosity increasing amount of the cellulosic arabinoxylan fiber with a composition to increase the viscosity of said composition.", "This summary is provided to introduce a selection of concepts in a simplified form that are further described below in the detailed description.", "This summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended as an aid in determining the scope of the claimed subject matter.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 shows a generic scheme for the preparation of cellulosic arabinoxylan fiber (CAF) as described below.", "FIG.", "2 shows the effects of shearing time on viscosity of 4% suspension of corn CAF sheared using a rotor-stator homogenizer at 15000 rpm as described below.", "FIG.", "3 shows the effect of multiple passes through a milk homogenizer at 4000 psi on the viscosity of a 1% suspension of corn CAF as described below.", "FIG.", "4 shows the effects of drying technique and shearing on corn CAF viscosity: Comparison of drum dried (DD) and spray dried (SD) CAF suspensions prepared with and without shear as described below.", "FIG.", "5 shows the effects of drying technique and shearing on sorghum CAF viscosity: Comparison of drum dried (DD) and spray dried (SD) CAF suspensions prepared with and without shear as described below.", "DETAILED DESCRIPTION OF THE INVENTION Disclosed are processes for producing novel “cellulosic arabinoxylan fiber” (CAF) and mixtures using agricultural products and/or lignocellulosic agricultural by-products (e.g., corn bran/fiber or other bran/fiber samples such as oat bran, wheal bran, barley straw and hull, sugarcane bagasse, sugar-beet bagasse, corn stover, wheat straw, sorghum bran) and/or lignocellulosic energy crops (e.g., switchgrass and Miscanthus).", "The term “agricultural materials” is defined herein as including agricultural products, lignocellulosic agricultural by-products, and lignocellulosic energy crops, individually or as mixtures.", "Cellulosic arabinoxylan fiber (CAF) can generally be prepared as follows: ground plant material (e.g., agricultural processing byproducts such as sorghum bran, corn bran, wheat bran, rice fiber, bailey bulls, sugar cane bagasse, sugar-beet bagasse, carrot pomace; agricultural residues such as cons stover, wheat straw, barley straw) and energy crops such as switchgrass, Miscanthus) was added to mechanically stirred hot water (85° C.).", "The pH of the suspended material was adjusted, generally to about 5.2 to 6.8 (e.g., 5.2 to 6.8; preferably 5.8) by adding 50% sodium hydroxide solution, and α-amylase (Novozymes, Inc. Davis, Calif.) was added and stirred for about 1 hour to hydrolyze starch.", "The pH of the slurry was raised to about 11.5 by adding 50% sodium hydroxide and stirred using a mechanical stirrer at about 85° C. for about an additional 30 minutes to completely deconstruct the material.", "During the reaction, the pH was kept at 11.5 by adding more 50% NaOH and the reaction volume was maintained the same by adding water as needed to compensate for water loss due to evaporation.", "The slurry of the deconstructed material was transferred into a container and immediately sheared, while it was still hot, for example using a high speed mixer/homogenizer Polytron (PT 10/35 GT) equipped with 12 mm probe (Brinkman Instruments) at about 10,000 rpm for about 1 hour.", "The solid residue was separated from the reaction mixture by centrifugation at about 14,000×g for about 10 minutes, and then suspended in boiling water and stirred using a mechanical stirrer for about 5 minutes.", "The hot suspension was transferred into a container and sheared at about 10,000 rpm for about 5 minutes.", "The sheared material was allowed to cool to room temperature and centrifuged at about 14,000×g for about 10 minutes to separate the solid.", "The separated solid was further suspended into boiling water in a container and boiled for about 5 minutes with stirring using a mechanical stirrer.", "The hot suspension was again transferred into a container, sheared at about 10,000 rpm for about 5 minutes and centrifuged at about 14,000×g for about 10 minutes to collect the solid residue.", "The solid residue was divided into two halves (since it was hard to process all material in one batch, so it was divided into two halves and each half was processed separately in the same way, and the final product from two halves were combined to calculate the final yield) and each half was processed to get a dry CAF as follows: One half of the solid material was suspended into boiling water, boiled for about 5 minutes with mechanical stirring, transferred into a container and sheared at about 20,000 rpm for about 5 minutes.", "Additional boiled water was added to this processed material and sheared again at about 20,000 rpm for about 1 minute.", "The solid was separated by centrifugation at about 14,000×g for about 10 minutes after cooling the hot sheared material to room temperature.", "The suspension of the solid material in hot water and its heating and shearing as above were repeated till a clear supernatant was seen.", "For most of the materials used, two repetitions (total three washings) were needed to obtain a clear supernatant.", "The final solid residue was collected, suspended into water to make slurry, and dried (e.g., drum or spray drying).", "As noted above, after removing the commercially valuable component “hemicelluloses” from, for example, corn fiber, the insoluble residue can be isolated, purified and its functionalities can be tested for commercial uses.", "Based on our studies, this residue, called “cellulosic arabinoxylan fiber” (CAF), had a unique water holding capacity and could be used, for example, as a food bulking agent and thickener.", "The CAF obtained during hemicellulose isolation from agricultural residues, agricultural processing byproducts and energy crops (such as sweet sorghum bagasse, biomass sorghum, switchgrass, miscanthus, etc.)", "had a similar water binding capacity leading to its application in the food industry as an insoluble dietary fiber and/or as a bulking agent.", "Such water-holding behavior of polymers is important for their functional roles in foods.", "Water holding capacity was closely linked to the nature of the gel network and its homogeneity, and there was much variation when comparing these cellulosic arabinoxylan materials from various sources of biomass.", "Such polymers have a significant market in food industries for making food gels.", "The term water-holding capacity is used to mean the amount of water retained by food materials in such a way that its exudation is prevented.", "The ability of fiber to hold water provides bulk and, when consumed, may cause a feeling of satiety without providing excessive calories.", "Thus in treating obesity, high fiber diets are recommended.", "Dietary fiber has also been shown to slow down gastric emptying and nutrient absorption may take place over a longer period.", "The water-holding capacity of dietary fiber has been proposed to be valuable in the diet to alter stool bulking (Gray, H., and M. L. Tainter, Am.", "J.", "Dig.", "Dis.", "8: 130-139 (1941)).", "Increased stool weight can cause shorter gut transit times limiting the exposure of the gut to toxins (Faivre, J., et al., Eur.", "J.", "Cancer Prevent., 1: 83-89 (1991); Reddy, B. S., et al., Cancer Res., 49: 4629-4635 (1989)).", "The compounds considered dietary fiber are generally split into two groups: water soluble and water insoluble.", "Gums, pectins, mucilages and hemicelluloses fall into the category of soluble fiber.", "Cellulose and lignin are considered insoluble.", "Fiber ingredients come from a number of sources and typically contain a mixture of soluble and insoluble fiber.", "Most fiber ingredients, especially insoluble forms, are derived from plants: grains like corn, wheat, soy and oats; legumes; fruit; and even trees.", "Purified cellulose fibers derived from a variety of sources are commonly used in bulking and calorie-reduction applications, but other types of fibers may provide different functional or physiological benefits.", "It is common to combine different sources of fiber to get the finished product characteristics we need.", "One of the main reasons is mouthfeel.", "Excess levels of one kind of fiber may produce an unacceptable “mouth feel” A bulking agent is an additive that contributes solids to provide texture/palatability and it increases the bulk of a food without affecting its nutritional value.", "Bulking agents are non-caloric additives used to impart volume and mass to a food.", "Water soluble dietary fibers (e.g., guar gum, xanthan gum, gum Arabic, carboxymethyl cellulose, other cellulose derivatives, etc.)", "are common forms of bulking agents.", "Gum arabic has been used in dietetic foods as a noncaloric bulking agent in special-purpose foods for diabetics.", "A mixture of gum arabic and xanthan gum has been used in the preparation of reduced-fat products such as butter, margarine, toppings, spreads, and frozen desserts.", "Bulking agents can be used to partially or completely replace high-caloric ingredients, such as sugar and/or flour, so as to prepare an edible formulation with a reduction in calories.", "Bulking agents are also useful as a source of soluble and/or insoluble fiber to be incorporated into foods and, unlike sucrose, are non-cariogenic, thus preventing tooth decay (U.S. Pat.", "No.", "5,811,148; Voragen, A. G. J., Trends Food Sci.", "Technol., 9:328-335 (1998)).", "CAF is a bulking agent due to its high water holding capacity, it increases the volume of the product in which it is added but it does not provide calories.", "The CAF produced by our processes was made without using hydrogen peroxide and by using high shear (e.g., about 10,000-20,000 rpm).", "The CAF was amide from multiple feedstocks.", "The CAF had high water binding properties, different rheologies, and different antioxidative capacities.", "This invention relates to substantially non-digestible bulking agents (i.e., CAF) for use in edible formulations and processes for preparing these agents.", "Bulking agents can be used to partially or completely replace high-caloric ingredients, such as sugar and/or flour so as to prepare an edible formulation with a reduction in calories.", "Also, the bulking agents are useful as a source of soluble fiber to be incorporated into foods and, unlike sucrose, are non-cariogenic.", "Among the edible formulations which may include the bulking agents are baked goods; puddings, creams and custards; jams and jellies; confections; soft drinks and other sweetened beverages, in liquid or dry form; sauces and salad dressings; ice cream and frozen desserts; foods which are sweetened; tabletop sweeteners and pharmaceuticals.", "The bulking agents herein may be employed alone, or as mixtures, in any edible formulation.", "The nature of the edible formulation will direct the selection of an appropriate bulking agent from those disclosed herein.", "The edible formulation may be liquid or dry, may be heat processed or frozen or refrigerated, and may contain appropriate high potency sweeteners.", "The bulking agents are stable to the temperature, oxygen content, enzymatic activity and pH conditions normally observed in the manufacture and storage of foods, pharmaceuticals and other edible formulations.", "Physical properties of CAF: CAF was characterized by surprisingly high water holding capacity, holding several grams of water per gram material (Table 3).", "For instance, CAF from corn bran held nearly 35 g of water per gram, while CAF prepared from barley straws held 21 g of water per gram.", "CAF suspensions surprisingly showed very high viscosity even at low concentrations.", "They also surprisingly showed shear thinning behavior (Table 5), which contributes to ease of processing since the material shows low viscosity during pumping in spite of the high viscosity at rest and at low shear rates.", "It is noteworthy that pumping itself did not cause the suspension to lose any viscosity, and the suspension was also stable over a wide range of temperature and pH values.", "The uniquely high water bedding capacity and viscosity enables numerous food applications of CAF, such as in sauces, dressings, baked products, meat products, dairy products, etc.", "(Tables 8-15).", "In these and other food systems, CAF can help to build viscosity, replace fat, control moisture migration and impart freeze-thaw stability.", "CAF suspensions have a smooth, non-gritty texture, which makes them excellent fat replacers, helping in the development of reduced or zero calorie formulations that maintain the body and texture of the original product.", "CAF can also function as a good emulsion stabilizer in food systems such as meat products as well as non-food systems such as oil drilling fluids.", "The spray dried CAF surprisingly hydrated very easily, yielding very high viscosity without any shearing during suspension.", "Shearing this suspension increased the viscosity further.", "Thus spray dried CAF is surprisingly a shear-optional viscosity modifier which gives high ease of use in food and non-food systems.", "Chemical properties of CAF: CAF was rich in non-digestible carbohydrates, with very low starch content (Table 2).", "This makes it a rich source of insoluble dietary fiber, enabling its potential use as a dietary fiber in food applications.", "The carbohydrate in CAF mainly consisted of glucose, xylose and arabinose.", "The xylose and arabinose were present in the form of a highly branched arabinoxylan, with a β-1,4 linked xylan backbone.", "The gluose polymer was mainly β-1,4 linked, indicating a cellulose-like polymer.", "However, there was a surprising amount of branching present in the glucose polymer in corn bran CAF (Table 7a).", "Without being bound by theory, this implies that this polymer may be partly responsible for the high water holding capacity of the CAF since it would decrease polymer crystallinity and afford more sites for water binding than cellulose.", "CAF also had antioxidant capacity, as evidence by the ORAC value (Table 4), which ranges from 326 μmole Trolox/100 g for CAF from barley straws to 1560 μmole Trolox/100 g for CAF from corn bran.", "This implies that CAF can offer significant health benefits as a source of antioxidants.", "Since CAF is prepared from natural lignocellulosic materials with no chemical modification of its constituent polymers, it is a natural, clean label additive.", "Thus, the unique physical and chemical properties of CAF enable them to be used in a wide variety of food and non-food applications requiring wide-ranging functionalities, while also offering ease of use, consistency and clean labels for food products.", "Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention belongs.", "As used herein, the term “about” refers to a quantity, level, value or amount that varies by as much as 30%, preferably by as much as 20%, and more preferably by as much as 10% to a reference quantity, level, value or amount.", "Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are now described.", "The following examples are intended only to further illustrate the invention and are not intended to limit the scope of the invention as defined by the claims.", "EXAMPLES Preparation of cellulosic arabinoxylan fiber (CAF): 200 g of ground plant material (e.g., agricultural processing byproducts such as sorghum bran, corn bran, wheat bran, rice fiber, barley hulls, sugar cane bagasse, sugar-beet bagasse, carrot pomace; agricultural residues such as corn stover, wheat straw, barley straw) and energy crops such as switchgrass, miscanthus) was added to mechanically stirred 1150 mL hot water (85° C.) in a 4 L beaker.", "The pH of the suspended material was adjusted, generally to about 5.2 to 6.8 (e.g., 5.2 to 6.8; preferably 5.8) by adding 50% sodium hydroxide solution, and 2 g of α-amylase (Novozymes, Inc. Davis, Calif.) was added and stirred for 1 hour to hydrolyze starch.", "The pH of the slurry was raised to 11.5 by adding 31.4 mL of 50% sodium hydroxide and stirred using a mechanical stirrer at 85° C. for an additional 30 minutes to completely deconstruct the material.", "During the reaction, the pH was kept at 11.5 by adding more 50% NaOH and the reaction volume was maintained the same by adding water as needed to compensate for water loss due to evaporation.", "The slurry of the deconstructed material was transferred into a 4 L plastic beaker and immediately sheared, while it was still hot, using a high speed mixer/homogenizer Polytron (PT 10/35 GT) equipped with 12 mm probe (Brinkman Instruments) at 10,000 rpm for 1 hour.", "The solid residue was separated from the reaction mixture by centrifugation at 14,000×g for 10 minutes, and then suspended in 2 L boiling water and stirred using a mechanical stirrer for 5 minutes.", "The hot suspension was transferred into a 4 L plastic beaker and sheared at 10,000 rpm for 5 minutes.", "The sheared material was allowed to cool to room temperature and centrifuged at 14,000×g for 10 minutes to separate the solid.", "The separated solid was further suspended into 2 L boiling water in a 4 L glass beaker and boiled for 5 minutes with stirring using a mechanical stirrer.", "The hot suspension was again transferred into 4 L plastic beaker, sheared at 10,000 rpm for 5 minutes and centrifuged at 14,000×g for 10 minutes to collect the solid residue.", "The total solid residue was divided into two halves (since it was hard to process all material in one batch, so it was divided into two halves and each half was processed separately in the same way, and the finale product from two halves were combined to calculate the yield) and each half was processed to get a dry CAF as follows: One half of the solid material was suspended into 2 L boiling water, boiled for 5 minutes with mechanical stirring, transferred into a plastic beaker and sheared at 20,000 rpm for 5 minutes.", "Additional 2 L boiled water was added to this processed material and sheared again at 20,000 rpm for 1 minute.", "The solid was separated by centrifugation at 14,000×g for 10 minutes after cooling the hot sheared material to room temperature The suspension of the solid material in hot water and its heating and shearing as above were repeated till a clear supernatant was seen.", "For most of the materials used, two repetitions (total three washings) were needed to obtain a clear supernatant.", "The final solid residue was collected, suspended into wafer to make slurry, and dried (e.g., drum or spray drying).", "Carbohydrate composition and linkage: The sugar composition of CAF samples was determined by following NREL Method (Laboratory Analytical Procedure 2008, Determination of Structural Carbohydrates and Lignin in Biomass).", "In brief, 0.3 g sample was suspended in 3 mL 72% (w/w) sulfuric acid in a test tube, mixed and incubated at 30° C. for 1 h with stirring at every 5 to 10 minutes.", "The sample suspension was transferred into a 100 mL Pyrex® glass bottle by using 84 mL water, which also diluted the acid to 2.48%.", "At this time standard sugar solutions were prepared by taking 0.1 g of each sugar in a Pyrex® bottle and adding 10 mL water and 348 uL 72% sulfuric acid to it, which made the final acid concentration 2.42%.", "The bottles containing samples and standard sugars were capped and placed in an autoclave at 121° C. for 1 h. After cooling to room temperature, an aliquot of 5 ml was taken from each autoclaved sample; its pH was adjusted between 5 and 7 by adding calcium carbonate and centrifuged (using a table top centrifuge at 13,000 rpm for 3.5 minutes) to remove the precipitated calcium sulfate.", "The supernatant was filtered by using Acrodisc LC 13 mm syringe filter (0.2 μm to remove any remaining solids and the filtrate was analyzed for sugars by Agilent 1200 HPLC that included a BioRad Aminex HPX-87H column at 60° C. and an Refractive Index (RI) detector.", "The mobile phase consisted of isocratic 5 mM H2SO4 eluant for 25 minutes, followed by a 5 min purge with the same eluant to clean RI detector to avoid base line drift prior to the next injection, at a flow rate of 0.6 ml/min.", "Sugars were quantified by using a calibration curve of standard sugars prepared with the same conditions.", "The glycosyl linkage composition was determined by gas chromatography-mass spectrometry (GC-MS) method.", "For this analysis, the sample was permethylated, depolymerized, reduced and acetylated.", "The resulting partially methylated alditol acetate (PMAAs) was analyzed by GC-MS as described by York et al., Methods Enzymol., 118: 3-40 (1986).", "Water holding capacity: The water holding capacity of CAF was determined according to AACC method 88-04 (AACC, 1995) with some modification.", "Briefly, 0.5 g CAF sample was weighed in a polypropylene centrifuge tube with screw cap.", "To each tube, 24.5 mL distilled water were added and the sample was sheared using a high speed Polytron at 10,000 rpm for 2 minutes and at 15,000 rpm for 1 minute.", "The tubes were placed on a shaker at room temperature and shaken at a moderate speed (e.g., about 160 rpm) for about 24 hours.", "Then they were centrifuged at 1,500×g for 15 minutes or 14,000×g for 1 h, excess water was decanted, and tubes were inverted to completely decant any residual water.", "Each tube was weighed.", "The amount of water held was calculated by subtracting the weight before water treatment and reported as gram of water adsorbed per gram of sample.", "Antioxidant activity: Highly reactive molecules like free radicals and reactive oxygen species are generated by normal cellular processes in the body, UV irradiation, and environmental stresses.", "These reactive molecules react with cellular components damaging DNA, carbohydrates, proteins, and lipids, causing injury to cells and tissues.", "Excess production or such reactive species can cause several diseases including cancer, diabetes, and atherosclerosis, etc.", "Most mammals have antioxidant systems to protect themselves from oxidative stress; however, an excess of free radical and/or reactive oxygen species can cause severe damage.", "One way to measure the antioxidant power of compositions, foods, and plant phytochemicals is to determine the Oxygen Radical Absorbance Capacity (ORAC) value of the composition.", "The ORAC antioxidant assay measures the loss of fluorescein over time due to peroxyl-radical formation by the breakdown of 2,2-azobis-2-methyl-propanimidamide, dihydrochloride (AAPH).", "Trolox, which is a water soluble vitamin E analog, serves as a positive control inhibiting fluorescein decay in a dose dependent manner.", "The ORAC assay is a kinetic assay measuring fluorescein decay and antioxidant protection over time.", "The antioxidant activity can be normalized to equivalent Trolox units to quantify the composite antioxidant activity present.", "This assay measures the material's antioxidant activity by hydrogen atom transfer.", "The higher ORAC score of a material is an indication of its, greater antioxidant capacity.", "The antioxidant activity was tested by measuring an ORAC values by a commercial laboratory using the following published procedures with some modification: Huang, D., et al., J. Agric.", "Food Chem., 50: 1815-1821 (2002); and Ou, B., et al., J. Agric.", "Food Chem., 50: 3122-3128 (2002).", "FIG.", "1 shows the generic scheme for the isolation, purification and drying of CAF.", "FIG.", "2 illustrates the effect of shearing time on the viscosity of a 4% corn bran CAF suspension.", "The sample used for this experiment had been drum dried and did not show high viscosity with no shear.", "However, as the suspension was sheared using a rotor-stator homogenizer at 15000 rpm for longer time, its viscosity surprisingly increased significantly.", "Without being bound by theory, this may be a result of particle size reduction and greater swelling of the particles due to shearing, leading to more water binding and an increase in the volume occupied by the CAF particles.", "A similar effect was observed by using a milk homogenizer at a pressure 4000 psi in lieu of the rotor-stator homogenizer.", "In this case, as shown in FIG.", "3, the viscosity of a 1% suspension of corn CA surprisingly increaes significantly with increasing number of passes through the homogenizer.", "The use of a milk homogenizer for increasing the viscosity of the CAF suspension offers the major advantage of scalability.", "In situ heat generation during the processing also helps to sterilize the product and prevent microbial growth.", "The fact that viscosity increased after each additional pass through the homogenizer or with increasing shearing time with the rotor-stator was quite surprising and illustrates the uniqueness of the CAF product.", "Most other viscosifying materials tend to be thixotropic in nature, and show a decrease in viscosity on being exposed to such high shear, due to loss of particle structure.", "Thus, this surprising increase in viscosity of CAF upon greater shearing is a unique characteristic of this product.", "FIGS.", "4 and 5 show comparisons of the flow behavior of 4% suspensions of drum dried and spray dried CAF from corn bran and Burgundy sorghum bran, prepared with and without shearing at 15000 and 10000 rpm.", "The viscosity was measured at shear rates between 0.13 and 130 s−1.It is clear that, in both cases, the drum dried CAF did not show high viscosity when prepared without any shearing (empty squares).", "When these samples were sheared for 3 minutes at 15000 rpm followed by 2 minutes at 10000 rpm, the viscosity surprisingly increased significantly (filled squares).", "The spray dried CAF from both sources surprisingly showed high viscosity (equivalent to drum dried samples with shear) even without shearing (empty triangles).", "It must be noted that all samples were allowed to hydrate for at least 3 hours before measurement of viscosity.", "When the spray dried samples were sheared, the viscosity surprisingly increased even further (filled triangles).", "Thus it is clear that the drum dried CAF samples requiring shearing along with hydration in order to give high viscosity.", "Spray dried samples, on the other hand, surprisingly showed high viscosity even with no shearing if they were allowed to hydrate sufficiently.", "Shearing these samples surprisingly leads to even higher viscosities which cannot be obtained with drum dried samples at this level of shearing.", "Table 1 shows the amount of CAF isolated from different plant materials, following the scheme given in FIG.", "1, varied from 14.30 to 59.90%.", "There was a significant range of yields of CAF from these plant materials.", "The rice fiber had the highest percent of CAF but had been previously treated by its manufacturer, which may have resulted in the high level of CAF.", "Corn stover, wheat straw, Miscanthus, sugarcane bagasse, and barley straw have more than 40% CAF and so they were all promising feedstocks for commercial scale production.", "The remaining plant materials had less than 20% yield, but could be used for CAF production if they are readily available.", "Table 2 shows the ash content of CAF isolated from all sources was less than 3% except corn stover (7.29%) and sugarcane bagasse (9.00%).", "Their protein content varied from 0.56 to 2.20 except CAP from sorghum, which was rich in protein (5.37 to 23.82%).", "CAF from sorghum bran had 0.91 to 5.42% residual starch but from all other sources the starch content was less than 0.36%.", "They all had either zero or very small amounts (less than 0.5%) of crude fat.", "As named (cellulose rich arabinoxylan fiber), they were very rich in neutral detergent fiber (95.50 to 99.75%) except from sorghum due to some residual starch present in it.", "More than 90% of the fiber present was insoluble dietary Fiber (except from Black and Sumac Sorghum bran).", "CAF from corn bran, corn stover, sorghum bran (black milled), sorghum bran (burgundy milled), barley hulls/straws and carrot pomace showed some soluble dietary fiber which can be due to presence of some water soluble carbohydrate.", "It is quite clear from this table that CAF isolated from all these plant materials ware almost pure dietary fiber, will be non-caloric in human diets, and will be very useful for making non-caloric food products.", "Table 3 shows the term water holding capacity (WHC), which was used to indicate the amount of water that the dietary fiber or any food material can retain.", "This property varied in the fibers isolated from different sources depending upon its carbohydrate composition, branching and molecular structure.", "The WHC in dietary fiber is considered to be valuable for many useful applications.", "The ability of fiber to hold water provided bulk and may cause feeling of satiety without providing calories Such property of fiber has been proposed to be valuable in the diet to alter stool bulking causing shorter gut transit times limiting exposure of the gut to bile acids and toxins.", "A fiber with a high WHC makes it an ideal ingredient to add in many food products to increase its volume without changing its texture and reducing calories per serving.", "As shown in Table 3, there was a remarkable variation in the WHC of CAF depending upon it source and also the process of drying from its slurry into solid form.", "The usual way to study the water holding behavior of fiber is to dissolve it in water mix overnight and centrifuge at about 1000×g for a short time (about 15 minutes).", "But these samples were also tested by centrifuging at a very high speed (14,000×g) for a loner period of time (1 h) to study their capacity to hold water even in very strong conditions for separating water from fiber.", "The WHC of these fibers varied from 6.374 to a surprising 34.81 g/g (water/fiber) by centrifugating them at 1,000×g for 15 minutes and from 4.971 to 15.397 g/g (water/fiber) by centrifugating at a higher speed (14,000×g) for 1 hour.", "In both conditions, the WHC of CAF from corn bran was surprisingly higher than the CAF from all other sources, suggesting a dramatic difference in their structures and branching.", "The drying process to make CAF also had a surprising effect on its WHC as seen in drum and spray dried material form corn bran.", "The WHC of spray dried CAF from corn bran was higher (34.81 and 15.397 at lower and higher centrifugation speed respectively) than the drum dried product (32.767 and 13.922 at lower and higher centrifugation speed respectively) showing a remarkable effect of the drying method used.", "At low speed and shorter centrifugation time, the WHC of CAF from both rice fiber and rice bran was low (6.374 and 5.036 respectively).", "But the WHC of CAF from other plant materials was higher, falling in the range of 13.845 to 34.81.Antioxidants terminate oxidation reactions in a food matrix or cell by donating hydrogen atoms or electrons, which are called reduction reactions.", "Phenolic compounds are a common antioxidant coming from the diet that breaks free radical chain reactions.", "In this study, the antioxidant activity was measured by ORAC assay, which is presented in Table 4.The ORAC assay was based on the principle that antioxidant compounds will prevent the production of peroxyl radicals.", "ORAC value is a measure of a compound's ability to delay the loss of fluorescence intensity over time.", "CAF isolated from all plant materials retained a considerable amount of phenolic compounds showing the ORAC antioxidant activity in the range of 326 to 1560 μmole Trolox/100 gram sample.", "The sugar composition, linkages and structural features of polysaccharides may also influence their antioxidant properties (Lo et al., Carbohydrate Polymers, 86: 320-327 (2010); Chattopadhyay, et al., Food Chemistry, 118: 823-829 (2010); Rao, et al., Phytochemistry, 67: 91-09 (2006)).", "Thus arabinose in the side chain and unsubstituted and/or monosubstituted xylose might have antioxidant activities.", "The drum dried CAF from corn bran had the highest ORAC value of 1560 Trolox/100 gram.", "Surprisingly, drum dried corn bran's CAF had comparatively higher ORAC value than the spray dried material from the same source, showing the effect of drying method on ORAC value.", "The reason for this is unknown but may be related to the retention or accessibility of phenolic compounds on the fiber.", "CAF from wheat bran, sorghum brans, switchgrass, barley hulls and rice fiber also had ORAC value above 600 μmole Trolox/100 gram.", "The ORAC value in the CAF from the remaining materials was less than 500 μmole Trolox/100 gram, which was still a high amount from the nutracetuicai point of view.", "Thus the product of this munition (CAF) has the ability to provide antioxidant activity m the diet as well as health-promoting dietary fiber.", "Such properties in foods are believed to play a role in preventing the development of chronic diseases such as cancer, heart disease, stroke, Alzheimer's disease, Rheumatoid arthritis, and cataracts.", "Table 5 summarizes the rheological properties of CAF from different biomasses.", "All the samples showed shear thinning behavior, with viscosity (at shear rate of 1 s−1) between 400-29000 times that of water.", "Spray dried corn bran CAF showed the highest viscosity, followed by CAF from sugar-beet bagasse and carrot pomace.", "Rice fiber and barley hull CAF showed the lowest viscosity, in agreement with their relatively low water holding capacity, as seen in Table 4.The Power Law model of rheological behavior was used to fit the flow behavior data.", "The model describes the flow behavior of the material in terms of the equations below, where σ represents the shear stress, {dot over (γ)} is the shear rate, η is the apparent viscosity and k and n are parameters.", "σ = k   γ .", "n η = σ γ .", "= k   γ .", "n γ .", "= k   γ .", "n - 1 The parameters of the Power Law model, calculated by fitting the apparent viscosity versus shear rate data, are good indicators of flow behavior of the material.", "The parameter ‘k’, which is called the flow consistency index, is a measure of the viscosity of the material at low shear rates, while ‘n’, which is the flow behavior index indicates how the viscosity changes as shear rate is increased.", "High values of k indicate that the material is thicker and more viscous at very low shear rates.", "Flow behavior index (n) value greater than 1 indicate that viscosity increases with shear rate, while values less than 1 indicate shear thinning behavior.", "The flow behavior data for each CAF was fitted using the Power Law model, and values of flow consistency index (K) and flow behavior index (n) were calculated (Table 5).", "Spray dried corn bran CAF showed the highest K value, which is in line with its high apparent viscosity at 1 s−1, as discussed before.", "Also as expected from the apparent viscosity data, barley hull CAF showed the lowest flow consistency index value.", "For all the CAF samples, n values are less than 1, indicating shear-thinning behavior.", "The differences between actual values were illustrative of the extent of shear thinning.", "Spray dried corn bran CAF showed the lowest n value of 0.25 (and thus greatest decrease in viscosity with increase in shear rate), while the drum dried corn bran CAF showed the highest n value (0.50).", "This data implies that, while all the different CAFs were capable of providing very high viscosity at low shear rates, the viscosity decreased significantly when the materials encountered very high shear rates, such as during pumping which could be a valuable property during manufacturing and packaging.", "Table 6 shows that the sugars present in CAF from all plant materials were glucose, xylose and arabinose, showing a typical cellulosic arabinoxylan structure.", "This was surprising since previous alkali-treated, insoluble products derived from com bran and biomass sources were assumed to be purified cellulose, and contained primarily glucose with little to no arabinose and xylose.", "Also, the rigorous purification process used (FIG.", "1) would he expected to remove all soluble arabinoxylan from the insoluble cellulosic materials.", "Table 6 shows, however, they contained about 34.78-73.87% glucose, 11.69-31.97% xylose, and 2.04-13.17% arabinose with total carbohydrate content varying from 70.85 to 96.83%.", "Thus, even with this level of extreme purification, measurable amounts of arabinose and xylose were present and under no circumstances were a pure “cellulose” prepared by these methods.", "The true structure of this Cellulosic Arabinoxylan Fiber is not known at this time.", "It could possibly be composed of sections of pure cellulose that entraps sections of pure arabinoxylan.", "Alternatively, it is not known whether cellulose and arabinoxylan polymers may be very strongly associated or covalently linked but together they make this fibrous material.", "A third possibility is that the CAF is made up of unique polysaccharides that contain both linear glucan regions and branched arabinoxylan regions.", "Regardless of the case, these materials represented novel fibrous materials not previously described.", "Table 7(a) shows glycosyl linkage analysis results for CAF from com bran, which demonstrated that it contained about 55.5 of (1→4)-linked glucose residues.", "This finding clearly showed that the major portion of this carbohydrate polymer was cellulose.", "It also clarified that it was not 100% cellulose but also contained xylose, arabinose and galactose.", "It looked like most of Xylp is present as (1→4)-linked backbone, which was highly branched on its 2, 3 position.", "The total percent of unbranched and branched (1→4) linked Xylp was 17.4% but only 5.2% of Xylp was present in the terminal position.", "A presence of high percent of arabinose, xylose, galactose and glucose (5.1, 5.2, 2.1 and 6.1% respectively) in the terminal position was a very good indication that it had a very highly branched structure.", "From these data, it is still not clear that whether (1→4)-linked Xylp backbone is covalently linked to (1→4)-linked glucose or it is very strongly associated due to its highly branched structure.", "But it was obvious that CAF contained a mixture of glucose- and xylose polymers, which were very branched and some other sugars were present in their side chains and terminal positions.", "Table 7 (b, c, d and e) show the glycosyl linkage analysis results for CAF from rice fiber, wheat straw, Miscanthus and sugarcane bagasse.", "The results demonstrated that they contained about 53.3 to 66.8% of (1-43 4)-linked glucose residue and about 23.7 to 32.8% of (1→4) linked Xylp residue as the major sugars.", "This finding clearly showed that as in CAF from corn bran (7a), the major portion of this carbohydrate polymer in all these CAF samples had cellulose like sugar backbone.", "It also demonstrated very clearly that though it had a cellulose link sugar backbone, it did not have a fully cellulose like structure.", "It also contained a high percentage (23.7 to 32.8%) of xylan in addition to glucose and a few percent of arabinose.", "Unlike CAF from corn bran, the Xylp present as (1→4)-linked backbone in CAF from all these four sources were not highly branched as indicated by their low percent of terminal arabinose, xylose and glucose.", "The percent of sugars linked at 2, 3, or 6 position in all of these four samples were lower than CAF from corn bran (FIG.", "7a), which further confirmed that they did not have a very highly branched structure.", "From these results, it is still not clear, whether the maintain two carbohydrate polymers [(1→4)-linked Xylp and (1→4)-linked glucose were covalently linked to each other or if they were just very strongly associated.", "Table 7(f) shows the glycosyl linkage analysis results for CAF from carrot pomace, which differs from the glycosyl linkages of CAF isolated not only from corn fiber (Table 7a) but also from rice fiber, wheat straw, Miscanthus and sugarcane bagasse (Table 7b, c, d and e).", "It contained a high percentage of (1→4)-linked glucose residues (67.8%) link CAF from other biomasses mentioned above.", "But its (1→4)-linked Xylp content (51%) was lower than CAF from other sources.", "As CAF from rice fiber wheat straw, Miscanthus and sugarcane bagasse, it had low percent of terminal sugars and less sugars linked at 2, 3 and 6 positions showing a ess branched structure than CAF from corn bran.", "Table 8, Benefits: Ease of use, no need to be prehydrated; high water holding capacity: equates to moisture control, reduces staling and cost reduction; cost neutral/cost savings due to additional water that is able to be bound; suitable for fresh baked, frozen par baked and fully baked products; reduces fat and calorie content with equal batter viscosity, height and cell structure compared to control; strengthen and add flexibility to fragile baked goods or snacks; provide clean and natural label as corn fiber or oat fiber.", "Table 9, benefits: high water holding capacity; equates to increase increased yield, control syneresis and act as a thickener; cost neutral/cost saving due to additional water that is able to be bound; replaces oils to reduce cost, improves nutritional values and mimics the mouth feel of fat; shear stable and so does not break down or lose viscosity through pumping, adds body and creaminess; stabilizes emulsions and suspends particulates; tolerant to heat stable and freeze/thaw stable; clean and natural label as corn fiber.", "Table 10, benefits: ease of use, no need to be prehydrated; controls moisture, reduces shrinkage and improves yield; freeze/thaw stable, retains emulsion of fat and water during freezing and cooking for a better eating qualities; cost effective extender and binder that increases yield in meat applications; improves texture and mouthfeel, no gel like or undesirable textures; fat deflection in breaded fried foods; clean and natural label as corn bran isolated ingredient.", "Table 11, benefits: ease of use, no need to be prehydrated; high water holding capacity, equates to texture control and act as a thickener; cost neutral/cost saving due to additional water that is able to be bound; replaces oils to reduce cost, improves nutritional values and mimics the mouth feel of fat; shear stable and so does not break down or lose viscosity through pumping, adds body and creaminess; stabilizes emulsions, suspends particulates and improves clink; tolerant to low pH, heat stable and freeze/thaw stable; clean and natural label as corn fiber.", "The cellulosic Arabinoxylan fiber was produced from multiple biomass feedstocks and without hydrogen peroxide, and spray drying gave a more functional product.", "Products made using CAF had higher water binding properties.", "Products made using CAF had different rheology compared to products prepared by U.S. Pat.", "No.", "5,766,662.Products using CAF had antioxidative capacity.", "All of the references cited herein, including U.S.", "Patents, are incorporated by reference in their entirety.", "Also incorporated by reference in its entirety is U.S. Pat.", "No.", "5,811,148.Thus, in view of the above, there is described (in part) the following: A process for the preparation of cellulosic arabinoxylan fiber comprising (or consisting essentially of or consisting of): (a) mixing ground agricultural materials in water at temperatures in the range of about 75° C. to about 100° C.", "(e.g., about 85° C.) to form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension, (b) adjusting the pH of said suspension to about 11.5, (c) subjecting said suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (d) mixing said solid residue with water at temperatures in the range of about 73° C. to about 100° C. to form a suspension, (e) subjecting said suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension, at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (f) mixing said solid residue from (e) with water at temperatures in the range of about 75° C. to about 100° C. to form a suspension, (g) subjecting said suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (h) mixing said solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (i) subjecting said suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (j) mixing said solid residue from (i) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension and subjecting said suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, and (k) repeating step (j) until a clear supernatant is obtained and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried cellulosic arabinoxylan fiber.", "The above process, comprising (or consisting essentially of or consisting of): (a) mixing ground agricultural materials in water at about 85° C. form a suspension, adjusting the pH of said suspension from about 5.2 to about 6.8, and adding thermostable α-amylase to said suspension and stirring about 1 hour.", "(b) adjusting the pH of said suspension to about 11.5 and stirring said suspension for about 30 minutes, (c) subjecting said suspension to shearing at about 10,000 rpm for about 1 hour and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (d) mixing said solid residue with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (e) subjecting said suspension from (d) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (f) mixing said solid residue from (e) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension, (g) subjecting said suspension from (f) to shearing at about 10,000 rpm for about 5 minutes, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (h) mixing said solid residue from (g) with water at temperatures in the range of about 75° C. to about 100° C. and stirring for about 5 minutes to form a suspension.", "(i) subjecting said suspension from (h) to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, (j) mixing said solid residue from (i) with water at temperatures in the range of about 75° C. to 100° C. and stirring for about 5 minutes to form a suspension and subjecting said suspension to a first shearing at about 20,000 rpm for about 5 minutes and subjecting said suspension to a second shearing at about 20,000 rpm for about 1 minute, cooling said suspension to about room temperature and centrifuging said suspension at about 14,000×g for about 10 minutes to form a supernatant and a solid residue, and (k) repeating step (j) until a clear supernatant is obtained and drying the final solid residue containing cellulosic arabinoxylan fiber to form dried cellulosic arabinoxylan fiber.", "The above process, wherein said drying in (k) is spray drying or drum drying.", "Cellulosic arabinoxylan fiber prepared by the above process.", "An edible formulation, comprising the cellulosic arabinoxylan fiber prepared by the above process, wherein said cellulosic arabinoxylan fiber functions as bulking agents in the edible formulation.", "A method of stabilizing (preventing oil droplets from colliding with each other (coalescence) to form larger droplets and separate from the solution making oily layer at the top) an emulsion, comprising (or consisting essentially of or consisting of) mixing an effective stabilizing amount of the cellulosic arabinoxylan fiber produced by the above process with an emulsion to stabilize said emulsion.", "A method of increasing the water holding capacity of a composition, comprising (or consisting essentially of or consisting of) mixing an effective water holding increasing amount of the cellulosic arabinoxylan fiber produced by the above process with a composition to increase the water holding capacity of said composition.", "A method of increasing the bulk of a composition, comprising (or consisting essentially of or consisting of) mixing an effective bulk increasing amount of the cellulosic arabinoxylan fiber produced by the above process with a composition to increase the water holding capacity of said composition.", "A method of increasing the viscosity of a composition, comprising (or consisting essentially of or consisting of) mixing an effective viscosity increasing amount of the cellulosic arabinoxylan fiber produced by the above process with a composition to increase the viscosity of said composition.", "Other embodiments of the invention will be apparent to those skilled in the art from a consideration of this specification or practice of the invention disclosed herein.", "It is intended that the speculation and examples be considered as exemplary only, with the true scope and spirit of the invention being indicated by the following claims.", "TABLE 1 Isolation of CAF from Plant Materials (% Yield, dry weight basis)a CAF Sources % Yield Corn bran 20.05 Corn stover 40.20 Rice fiber 59.90 Wheat bran 14.30 Wheat straw 53.10 Switchgrass 32.70 Miscanthus 56.70 Sugarcane bagasse 52.00 Sorghum bran (Black milled) 25.84 Sorghum bran (Sumac milled) 38.50 Sorghum bran (Burgundy milled) 19.32 Barley hulls 26.85 Barley straws 49.75 Carrot pomace 14.80 aWeight percent based on de-starched biomass TABLE 2 Proximate Composition and Dietary Fiber Content of CAF Isolated from Plant Materials (d.w.b.)", "CAF Sources Ash Protein Starch NDF Crude Fat ISD SDF TDF Corn bran 1.54 0.56 ± 0.00 0.26 ± 0.01 92.58 ± 0.35 0.21 92.44 4.09 96.54 Corn stover 7.29 1.29 ± 0.00 0.16 ± 0.08 96.92 ± 0.10 0.10 95.30 0.89 96.20 Rice fiber 2.25 0.91 ± 0.05 0.21 ± 0.04 95.11 ± 0.72 0.04 98.63 0.00 98.63 Wheat bran 1.05 1.72 ± 0.08 0.36 ± 0.03 90.48 ± 0.41 0.00 92.03 0.00 92.03 Wheat straw 2.27 1.75 ± 0.00 0.05 ± 0.03 99.75 ± 0.21 0.36 97.55 0.00 97.55 Switchgrass 1.35 1.90 ± 0.04 0.09 ± 0.02 98.22 ± 0.31 0.48 99.45 0.00 99.45 Miscanthus 1.08 0.56 ± 0.05 0.16 ± 0.03 98.71 ± 0.15 0.14 99.61 0.00 99.61 Sugarcane 9.90 1.91 ± 0.00 0.06 0.04 98.55 ± 0.41 0.25 90.82 0.00 90.82 bagasse Sorghum bran 1.76 16.49 ± 0.09 2.51 ± 0.05 87.06 ± 0.14 0.40 77.88 1.98 79.86 (Black milled) Sorghum bran 1.07 23.82 ± 0.23 5.42 ± 0.24 70.04 ± 0.85 0.28 77.62 0.00 77.25 (Sumac milled) Sorghum bran 1.63 5.37 ± 0.06 0.91 ± 0.09 94.70 ± 0.18 0.28 91.80 9.44 101.89 (Burgundy milled) Barley hulls 1.00 0.89 ± 0.04 0.09 ± 0.08 96.54 ± 0.29 0.15 98.51 4.15 102.65 Barley straws 1.04 0.66 ± 0.03 0.11 ± 0.04 99.34 ± 0.39 0.44 97.57 6.84 104.41 Carrot pomace 1.79 2.20 ± 0.07 0.22 95.50 ± 0.59 0.70 94.7 ± 1.4 1.4 96.2 TABLE 3 Water Holding Capacity of CAF Isolated from Plant Materials Water Held/ Water Held/ Sample (g/g) Sample(g/g) (Centrifugation, (Centrifugation, CAF Sources 14K, 1 h) 1K, 15 min.)", "Corn bran (Drum Dried CAF) 13.922 ± 0.434 32.767 ± 0.972 Corn bran (Spray Dried CAF) 15.397 ± 0.513 34.807 ± 0.378 Corn stover 7.159 ± 0.105 17.71 ± 1.33 Rice fiber 4.971 ± 0.099 6.374 ± 0.422 Wheat bran 6.782 ± 0.188 13.940 ± 0.479 Wheat straw 7.103 ± 0.452 23.748 ± 0.410 Switchgrass 6.768 ± 0.085 19.782 ± 0.714 Miscanthus 6.681 ± 0.188 16.847 ± 0.555 Sugarcane bagasse 7.082 ± 0.419 17.28 ± 0.73 Sorghum bran (Black milled) 5.538 ± 0.406 20.053 ± 0.746 Sorghum bran (Sumac milled) 5.190 ± 0.201 20.127 ± 0.189 Sorghum bran (Burgundy 7.525 ± 0.580 32.807 ± 1.045 milled) Barley hulls 6.167 ± 0.258 13.845 ± 0.259 Barley straws 7.622 ± 0.290 21.387 ± 0.590 Carrot pomace ND 22.91 ± 1.94 CAF prepared at Z Trim Holdings, Inc. Plant Corn bran (Drum dried CAF) 9.257 ± 0.294 32.658 ± 0.619 Corn bran (Spray dried CAF) 10.763 ± 0.760 34.807 ± 0.378 Rice fiber 5.036 ± 0.158 7.950 ± 0.274 TABLE 4 ORAC Value of CAF Isolated from Plant Materials ORAC Value CAF Sources (μmole Trolox/100 gram) Corn bran (Drum Dried CAF) 1560 Corn bran (Spray Dried CAF) 868 Corn stover 362 Rice fiber 414 Wheat bran 954 Wheat straw 493 Switchgrass 649 Miscanthus 392 Sugarcane bagasse 427 Sorghum bran (Black milled) 633 Sorghum bran (Sumac milled) 792 Sorghum bran (Burgundy milled) 938 Barley hulls 679 Barley straws 326 Carrot pomace 352 CAF prepared at Z Trim Holdings, Inc. Plant Corn bran (Drum dried CAF) 1560 Corn bran (Spray dried CAF) 868 Rite fiber 942 TABLE 5 Rheological properties of 4% suspensions of CAF Isolated from Plant Materials: Apparent viscosity and Power Law parameters Apparent viscosity at Flow Flow shear rate consistency behavior of 1 s−1 index “K” index (cP) (Pa · sn) (n) Corn bran (Drum 8500 10.45 0.50 Dried CAF) Corn bran (Spray 29100 36.45 0.25 Dried CAF) Corn stover 1900 2.72 0.36 Rice fiber 418 1.04 0.41 Wheat bran 639 0.78 0.41 Wheat straw 7770 11.11 0.26 Miscanthus 1760 2.43 0.36 Sugarcane bagasse 5730 6.97 0.27 Sorghum bran (Black 1030 1.49 0.46 milled) Sorghum bran 7250 9.35 0.45 (Sumac milled) Sorghum bran 4750 6.36 0.43 (Burgundy milled) Barley hulls 540 0.727 0.38 Barley straws 3450 4.93 0.32 Carrot pomace 8620 13.32 0.26 Sugar-beet bagasse 11700 18.31 0.32 TABLE 6 Carbohydrate Composition of CAF Isolated from Plant Materials Sugar Content (Wt.", "%) Glucose Xylose Arabinose Total Corn bran (Drum 52.18 31.56 12.29 96.03 Dried CAF) Corn bran (Spray 51.60 31.08 12.00 94.68 Dried CAF) Corn stover 66.87 21.9 2.23 91.00 Rice fiber 64.67 20.47 2.04 87.18 Wheat bran 34.78 31.97 13.17 79.92 Wheat straw 60.72 23.30 2.69 86.71 Switchgrass 59.65 24.02 2.81 86.48 Miscanthus 60.74 21.39 2.33 84.46 Sugarcane bagasse 57.99 23.33 2.31 83.63 Sorghum bran 46.34 14.03 10.48 70.85 (Black milled) Sorghum bran 54.79 11.69 7.87 74.35 (Sumac milled) Sorghum bran 59.34 17.10 11.49 87.93 (Burgundy milled) Barley hulls 52.89 31.66 5.74 90.29 Barley straws 66.70 21.74 2.52 90.96 Carrot pomace 73.87 14.46 2.38 90.71 CAF prepared at Z Trim Holdings, Inc. Plant Corn bran (Drum 55.88 28.40 10.92 95.20 dried CAF) Corn bran (Spray 62.14 24.92 9.77 96.83 dried CAF) Rice fiber 70.63 20.05 1.70 92.38 TABLE 7(a) Glycosyl-linkage composition of CAF isolated from corn bran Relative peak Glycosyl residue linkage area (%) t-Araf (terminally linked arabinofuronosyl residue) 5.1 t-Xylp (terminally linked xylopyranosyl residue) 5.2 2-Araf (2-linked arabinofuranosyl residue) 2.1 t-Glc (terminally linked glucopyranosyl residue) 6.1 3-Araf (3-linked arabinofuranosyl residue) 2.0 t-Gal (terminally linked galactopyranose residue) 2.9 3-Xylp & 4-Arap or 5-Araf (3-linked xylopyranose 0.8 residue & 4-linked arabinopyranose residue or a 5-linked arabinofuranose residue.)", "4-Xylp (4-linked xylopyranosyl residue) 5.9 3-Glc (3-linked glucopyranosyl residue) 0.7 3-Gal (3-linked galactopyranose residue) 0.3 4-Man (4-linked mannopyranosyl residue) 0.7 2-Gal (2-linked galactopyranose residue) 0.0 6-Glc (6-linked glucopyranosyl residue) 0.1 4-Glc (4-linked glucopyranosyl residue) 55.5 3,4-Xylp (3,4-linked xylopyranosyl residue) 7.7 3,4-Glc (3,4-linked glucopyranosyl residue) 0.8 2,4-Glc (3,4-linked glucopyranosyl residue) 0.4 4,6-Glc (4,6-linked glucopyranosyl residue) & 3.8 2,3,4-Xylp (2,3,4-linked xylopyranosyl residue) Total 100.0 TABLE 7(b) Glycosyl-linkage composition of CAF isolated from rice fiber Relative peak Glycosyl residue linkage area (%) Terminal Arabinofuranosyl residue (t-Araf) 1.2 Terminal Xylopyranosyl residue (t-Xyl) 0.9 2 linked Arabinofuranosyl residue (2-Araf) 0.2 Terminal Glucopyranosyl residue (t-Glc) 2.0 3 linked Arabinofuranosyl residue (3-Araf) 0.1 Terminal Galactopyranosyl residue (t-Gal) 0.2 4 linked Arabinopyranosyl residue or 5 linked 0.1 Arabinofuranosyl residue (4-Arap or 5-Araf) 4 linked Xylopyranosyl residue (4-Xyl) 23.7 4 linked Mannopyranosyl residue (4-Man) 0.1 4 linked Glucopyranosyl residue (4-Glc) 66.8 2,4 linked Xylopyranosyl residue (2,4-Xyl) 0.5 3,4 linked Xylopyranosyl residue (3,4-Xyl) 1.7 3,4 linked Glucopyranosyl residue (3,4-Glc) 0.8 2,4 linked Glucopyranosyl residue (2,4-Glc) 0.7 4,6 linked Glucopyranosyl residue (4,6-Glc) 1.2 Total 100 TABLE 7(c) Glycosyl-linkage composition of CAF isolated from wheat straw Relative peak Glycosyl residue linkage area (%) Terminal Arabinofuranosyl residue (t-Araf) 2.4 Terminal Xylopyranosyl residue (t-Xyl) 1.1 2 linked Arabinofuranosyl residue (2-Araf) 0.1 Terminal Glucopyranosyl residue (t-Glc) 1.5 3 linked Arabinofuranosyl residue (3-Araf) 0.1 Terminal Galactopyranosyl residue (t-Gal) 0.2 4 linked Arabinopyranosyl residue or 5 linked 0.2 Arabinofuranosyl residue (4-Arap or 5-Araf) 4 linked Xylopyranosyl residue (4-Xyl) 26.1 3 linked Glucopyranosyl residue (3-Glc) 0.7 3 linked Galactopyranosyl residue (Gal) 0.1 6 linked Glucopyranosyl residue (6-Glc) 0.1 4 linked Glucopyranosyl residue (4-Glc) 60.3 2,4 linked Xylopyranosyl residue (2,4-Xyl) 0.8 3,4 linked Xylopyranosyl residue (3,4-Xyl) 2.9 3,4 linked Glucopyranosyl residue (3,4-Glc) 0.9 2,4 linked Glucopyranosyl residue (2,4-Glc) 0.9 4,6 linked Glucopyranosyl residue (4,6-Glc) 1.6 Total 100 TABLE 7(d) Glycosyl-linkage composition of CAF isolated from miscanthus Relative peak Glycosyl residue linkage area (%) Terminal Arabinofuranosyl residue (t-Araf) 1.8 Terminal Xylopyranosyl residue (t-Xyl) 0.8 2 linked Arabinofuranosyl residue (2-Araf) 0.1 Terminal Glucopyranosyl residue (t-Glc) 1.8 3 linked Arabinofuranosyl residue (3-Araf) 0.1 Terminal Galactopyranosyl residue (t-Gal) 0.1 4 linked Arabinopyranosyl residue or 5 linked 0.2 Arabinofuranosyl residue (4-Arap or 5-Araf) 4 linked Xylopyranosyl residue (4-Xyl) 24.3 3 linked Glucopyranosyl residue (3-Glc) 0.4 4 linked Mannopyranosyl residue (4-Man) 0.2 4 linked Galactopyranosyl residue (4-Gal) 0.1 4 linked Glucopyranosyl residue (4-Glc) 65.2 2,4 linked Xylopyranosyl residue (2,4-Xyl) 0.6 3,4 linked Xylopyranosyl residue (3,4-Xyl) 2.3 3,4 linked Glucopyranosyl residue (3,4-Glc) 0.6 2,4 linked Glucopyranosyl residue (2,4-Glc) 0.5 4,6 linked Glucopyranosyl residue (4,6-Glc) 1.1 Total 100 TABLE 7(e) Glycosyl-linkage composition of CAF isolated from sugarcane bagasse Relative peak Glycosyl residue linkage area (%) Terminal Arabinofuranosyl residue (t-Araf) 1.7 Terminal Xylopyranosyl residue (t-Xyl) 0.8 2 linked Arabinofuranosyl residue (2-Araf) 0.1 Terminal Glucopyranosyl residue (t-Glc) 0.8 3 linked Arabinofuranosyl residue (3-Araf) 0.1 Terminal Galactopyranosyl residue (t-Gal) 0.1 4 linked Arabinopyranosyl residue or 5 linked 0.2 Arabinofuranosyl residue (4-Arap or 5-Araf) 4 linked Xylopyranosyl residue (4-Xyl) 32.8 3 linked Glucopyranosyl residue (3-Glc) 1.0 4 linked Mannopyranosyl residue (4-Man) 0.2 6 linked Glucopyranosyl residue (6-Glc) 0.1 4 linked Galactopyranosyl residue (4-Gal) 0.1 4 linked Glucopyranosyl residue (4-Glc) 53.3 2,4 linked Xylopyranosyl residue (2,4-Xyl) 1.1 3,4 linked Xylopyranosyl residue (3,4-Xyl) 3.3 3,4 linked Glucopyranosyl residue (3,4-Glc) 1.0 2,4 linked Glucopyranosyl residue (2,4-Glc) 1.1 4,6 linked Glucopyranosyl residue (4,6-Glc) 2.1 Total 100 TABLE 7(f) Glycosyl-linkage composition of CAF isolated from carrot pomace Relative peak Glycosyl residue linkage area (%) Terminal Arabinofuranosyl residue (t-Araf) 1.4 Terminal Fucopyranosyl residue (t-Fuc) 0.2 Terminal Arabinopyranosyl residue (t-Ara) 0.1 Terminal Xylopyranosyl residue (t-Xyl) 0.7 2 linked Rhamnopyranosyl residue (2-Rha) 0.2 Terminal Mannopyranosyl residue (t-Man) 0.9 Terminal Glucopyranosyl residue (t-Glc) 2.5 3 linked Arabinofuranosyl residue (3-Araf) 0.1 Terminal Galactopyranosyl residue (t-Gal) 1.1 4 linked Arabinopyranosyl residue or 5 0.5 linked Arabinofuranosyl residue (4-Arap or 5-Araf) 4 linked Xylopyranosyl residue (4-Xyl) 5.1 2,4 linked Rhamnopyranosyl residue (2,4-Rha) 0.5 2 linked Glucopyranosyl residue (2-Glc) 0.1 4 linked Mannopyranosyl residue (4-Man) 7.7 2 linked Galactopyranosyl residue (2-Gal) 0.3 3,4 linked Arabinopyranosyl residue or 3,5 0.3 linked Arabinofuranosyl residue (3,4-Arap or 3,5-Araf) 4 linked Galactopyranosyl residue (4-Gal) 3.3 4 linked Glucopyranosyl residue (4-Glc) 67.8 2,4 linked Xylopyranosyl residue (2,4-Xyl) 0.4 3,4 linked Glucopyranosyl residue (3,4-Glc) 1.3 2,4 linked Mannopyranosyl residue (2,4-Man) 0.1 2,4 linked Glucopyranosyl residue (2,4-Glc) 2.3 4,6 linked Mannopyranosyl residue (4,6-Man) 0.2 4,6 linked Glucopyranosyl residue (4,6-Glc) 2.9 2,3,4 linked Glucopyranosyl residue (2,3,4-Glc) 0.2 Total 100 TABLE 8 Use of Corn and Oat CAF in Bakery Products for Different Functionalities (Suggested Amount) Corn CAF Oat CAF Products (Wt.", "%) (Wt.", "%) Functions Biscuits 0.25-0.75 1.0-1.5 Moisture retention, slow staling and fat reduction Buns and Rolls 0.30-0.75 0.30-0.75 Moisture retention and fat reduction Muffins and 0.50-1.0 1.0-2.0 Trans and saturated Sweet Breads fat reduction) Cakes and Bakery 0.30-0.50 0.50-1.00 Volume increase, Mixes structure improvement and fat reduction Cookies and 0.20-0.50 0.20-0.50 Moisture retention Brownies and fat reduction Pie Dough, Pizza 0.50-1.0 0.75-1.5 Breakage reduction, Dough and Pita fat reduction and Bread improvement in moisture migration Pie Filling 0.30-1.0 Corn ZTrim Syneresis reduction, recommended fat reduction and cost reduction Tortillas 0.20-0.50 0.50-1.0 Fat reduction, structure improvement, cost reduction Crackers and 0.25-0.50 0.50-1.0 Breakage and Snack Foods checking reduction Enrobed 0.25-1.0 0.50-1.0 Moisture retention Microwave Dough Batter and 0.50-2.0 0.50-2.5 Fat uptake Breading reduction and crispiness improvement Gluten Free 0.30-0.50 0.50-1.0 Volume Products increase and structure improvement Note: Actual usuage will vary depending applications.", "TABLE 9 Use of Corn CAF in Bakery Products for Different Functional (Suggested Amount) Corn CAF Products (Wt.", "%) Functions Cream Cheese 0.50-2.0 Improves yield and reduces fat and cost Ricotta Cheese 0.50-1.0 Improves yield and reduces fat and cost Processed Cheese 0.25-1.0 Improves yield and and Cheese Sauces reduces fat and cost Sour Cream and Dip 0.50-3.0 Improves yield and reduces fat and cost.", "Also thickener and viscosity builder Ice Cream, 1.25-1.25 Improves mouth feel, Ice Milk and controls ice crystal Frozen formation and thaw Novelties stabilization Pudding and 0.50-3.0 Improves yield and Custards reduces fat and cost.", "Also thickener and viscosity builder Whipped 0.30-0.75 Stabilizes foam Toppings and reduces cost Yogurt, Yogurt 0.10-0.50 Stabilizer, thickener/ Drinks and viscosity builder Smoothies and control syneresis Note: Actual usage will vary depending upon application.", "TABLE 10 Use of Corn CAF in Meat Products for Different Functionalities (Suggested Amount) Corn Products CAF (%) Functions Ground Beef 0.25-1.0 Reduces cost and Patty improves yield and texture Ground Turkey and 0.50-1.0 Reduces cost and Chicken Patty improves yield and texture Sausage and 0.50-1.0 Binder and reduces Hot Dogs cost and improves yield Meat Fillings 0.25-075 Emulsification and syneresis control Coating and 0.50-2.0 Improves adhesion Breading and reduces fat in for Meats fried food Note: Actual usage will vary depending upon application.", "TABLE 11 Use of Corn CAF in Dressing, Sauces, Mayo and Dips for Different Functionalities (Suggested Amounts) Corn CAF Products (Wt.", "%) Functions Mayo Spread 0.50-3.0 Reduces cost and fat Spoonable 0.50-3.0 Reduces cost Salad Dressings and fat Pourable Salad 0.50-2.0 Reduces cost Dressings and fat Dips 0.50-3.0 Reduces cost and fat Sauces 0.50-2.0 Reduces cost and fat Salsa 0.25-0.50 Reduces cost and controls syneresis Barbecue and 0.25-1.0 Thickener, Tomato Sauces viscosity builder and control syneresis Note: Actual usage will vary depending upon application.", "TABLE 12 Formulations of stable free flowing (A) fat powder (B) gravy, and (C) soup using corn CAF (A) Fat powder (Wt, g) Wt.", "% Corn BFG 47.00 47.00 Coconut Oil 26.00 26.00 Shortening 24.00 24.00 Salt 0.50 0.50 Trisodium Phosphate 0.50 0.50 Disodium Phosphate 1.00 1.00 Corn CAF 1.00 1.00 Total 100 100 (Wt., g) Wt.", "% (B) Dry Gravy Mix Corn CAF 5.40 22.50 Chicken Bouillion 6.00 25.00 Black Pepper 34 mesh 0.20 0.83 Corn BFG and fat blend 12.40 51.67 24 100 Add 1 part gravy mix to 9 parts of bot-water (C) Chicken Cream Soup Dry Mix Nonfat dry powdered milk 50.00 54.82 Dried onion flakes 4.00 4.39 Chicken Bouillion 10.00 10.96 Dried basil 0.20 0.22 Dried thyme 0.40 0.44 Black pepper 34 mesh 0.50 0.55 Corn CAF 8.10 8.88 Corn BFG and fat blend 18.00 19.74 91.20 100 Add 1 part soup to part of hot water Note: The free flowing fat powder can be incorporated in formulation of stable dry mixes of gravy, chicken cream soup, and many other products of similar attributes.", "CAF is used to stabilize the fat in powder form and for ease of use.", "TABLE 13 Formulations of bars and nutritional drinks with corn CAF in combination with corn BFG for fiber fortification up to more 5% or 2.75 gram per serving.", "Item Quantity (g) Percentage (A) CAF Nutritional Bar with 5 grams of Fiber/Serving, 3:1 Corn BFG:CAF Apple Juice Concentrate 28.18 15.76 Corn CAF 3.50 1.96 Corn BFG 10.50 5.87 Salt 1.25 0.70 Chocolate Baking Chips Semi-Sweet 30.00 16.78 Texturized Protein (Toasted) 6.56 3.67 TVP 6.56 3.67 Soybean Oil 12.50 6.99 Flax Seed 6.00 3.36 Vanilla Extract 1.25 0.70 Brown Sugar 15.00 8.39 Honey 19.38 10.84 Molasses 1.88 1.05 Soy Protein Isolate 13.75 7.69 Rolled Oats 5.00 2.80 Puffed Rice 17.50 9.79 Totals 178.81 100.00 Procedures: 1.Hydrate CAF with the Apple Juice Concentrate.", "2.Mix all other liquids in with CAF Gel/ Slurry.", "3.Add all remaining powders.", "4.Incorporate all other pieces until All coated with liquid mixture.", "5.Form into bars and bake at 250° F. Until dried approx.", "20 minutes (B) CAF Nutritional Drink with 12 grams Fiber/Serving.", "10:1 Corn BFG:CAF Water 396.00 76.36 Corn CAF 2.00 0.39 Corn BFG 20.50 3.95 Sugar 35.00 6.75 Non Fat Dry Milk 25.00 4.82 Cocoa Powder 10.00 1.93 Dark Chocolate Flavor-Flavor Chem.", "1.33 0.26 Vanilla-Tahiti-Neilson Massey 0.65 0.13 Soybean Oil 10.00 1.93 HFCS-Chicago Sweeteners 15.00 2.89 Xanthan Gum 1.00 0.19 Soy Protein Isolate 2.00 0.39 Chocolate Flavor-Flavor Chem.", "0.15 0.03 Totals 518.63 100.00 Procedures: 1.Mix Water and CAF To form a gel slurry.", "2.Add the NFDM.", "Continue to mix.", "3.Add the Sugar, HFCS, Cocoa Powder, Soy Protein Isolate, continue to mix.", "4.Add Soybean Oil, corn BFG, and Xanthan Gum.", "Add Flavors.", "5.Add Flavors.", "6.Run Mix through shear to assure Smooth silky texture.", "NOTES: % Moisture 14.0% approx.", "CAF is used to modify viscosity, manage moisture, lower water activity to extend shelf-life, allow for pliability during extrusion to minimize breakage, remove glycerin and to replace caloric viscosity modifiers.", "NOTES: Viscosity: Spindle #3 @ 12 rpm's = 1650-1700 cps; CAF is used to modify the viscosity, keep solids suspended functionalize flavors by VSiell distributing them throug,imt the system, r(rmove or viscosity modifiers, remove calorie contributing ViSCOSity modifiers, ultra high shear and temperature.", "TABLE 14 Formulations of food emulsions such as Alfredo sauce, Macroni and Cheese sauce, and shelf-stable ranch dressing with corn CAF and corn BFG blends Ingredients Quantity (g) Percentage (A) Cheese sauce for Macaroni and Cheese Water 238.88 60.01 Soybean Oil 5.66 1.42 Whey Powder-Sweet 21.72 5.46 Mac and Cheese Blend 8.80 2.21 NFDM 12.92 3.25 Supernatural Cheese Blend 10.96 2.75 *Sartori-intensa cheddar 82.32 20.68 Corn BFG 10.72 2.69 Corn CAF 3.04 0.76 Butterbuds-Aged cheddar 1.19 0.30 Butterbuds-Buttermilk 0.66 0.17 Butterbuds-High 0.97 0.24 Concentration Xanthum Gum 0.20 0.05 Total 398.04 100.00 (B) Corn CAF Alfredo sauce Water 290.36 51.49 Milk (skim) 129.00 22.87 Nonfat Dy Milk 10.00 1.77 Corn CAF 6.90 1.22 Cream Powder 3.00 0.53 Corn BFG 3.50 0.62 Soybean Oil 48.21 8.55 Swiss Cheese 54.34 9.64 Butterbuds, high concentrate 5.47 0.97 Cheesebuds, Parmesan 3.10 0.55 Cheesebuds, Emmenthal 2.49 0.44 Salt 5.20 0.92 Koji Aji 1.10 0.20 Garlic Powder 0.40 0.07 Black pepper (34 msh) 0.39 0.07 Black pepper (20 msh) 0.25 0.04 White pepper 0.10 0.02 Nutmeg 0.15 0.03 563.96 100.00 (C) Shelf Stable Dressing Ingredients Percentage Quantity (g) Water 66.2732 730.5360 Extra heavy duty mayo 19.5045 215.0000 Vinegar, 120 GR.", "3.0010 33.0800 HFCS 2.9937 33.0000 Corn CAF 2.0003 22.0500 Salt 1.8020 19.8640 Egg Yolks 0.9979 11.0000 MSG 0.6006 6.6200 Buttermilk Powder 0.4999 5.5100 Granulated Garlic 0.4999 5.5100 Corn BFG 0.3003 3.3100 Autolyzed Yeast 0.3003 3.3100 Lactic Acid 0.3003 3.3100 Lemon Concentrate 0.2005 2.2100 Granulated Onion 0.1197 1.3200 Potassium Sorbate 0.0998 1.1000 Sodium Benzoate 0.0998 1.1000 Starter Distillate 0.0998 1.1000 Citric Acid 0.0998 1.1000 Lemon Flavor, Weber 0.0798 0.8800 Black pepper 34 mesh 0.0499 0.5500 Dill weed, whole 0.0336 0.3700 Parsley granules 0.0336 0.3700 Nisin preservative 0.0100 0.1100 100.0000 1102.3100 NOTES: 1.Combine water, corn CAF and corn BFG.", "Shear for 3 min using an emulsion blender.", "2.Add soybean oil to xanthum gum, mix well and add to mixture.", "Shear for another minute.", "3.Add all dry ingredients and supernatural cheese blend then shear.", "4.Heat in double boiler to 190° F. 5.Remove from heat and add Sartori cheese and mix until melted.", "*used Sartori-Intensa Cheese Product becauce no other American Cheese was Provided.", "6.Add to Elbo Macaroni and toss.", "CAF allows for excellent microwaveability by well distributing and managing water, reduce saturated fat, reduce calories, allows for emulsification stability, and also allows for excellent freeze/thaw.", "NOTES: 1.Combine water and corn CAF.", "Shear for 3 min using an emulsion blender.", "2.Add soybean oil to xanthum gum, mix well and add to mixture.", "Shear for another minute.", "3.Add all dry ingredients and shear.", "4.Add Swiss cheese to mixture and heat in a sauce pan until cheese is melted.", "About 150° F. 5.Remove from heat.", "6.Shear with the emulsion blender for about 2 minutes.", "CAF eliminates syneresis, eliminates emulsion breakage and oil separation, reduce saturated fats, allows for excellent freeze/thaw, contributes to calorie reduction Ph: avg.", "3.81 Salt: avg.", "2.42 % TA avg.", "0.85 Allows for emulsions stability under ambient storage, contributes to lowering calories by lowering the fat content, keeps solids well distributed and suspended.", "TABLE 15 Formulation of chocolate pudding and pita chips with corn CAF and corn BFG (A) Z Trim Chocolate Pudding Quantity Item (Grams) Percentage Evaporated Milk 2% 389.14 37.585 Corn CAF 25.77 2.489 Skim Milk 357.86 34.564 Sugar 175.27 16.928 NFDM 20.94 2.022 Semi Sweet Chocolate pieces 57.75 5.578 Vanilla extract 4.73 0.457 Corn BFG 2.00 0.193 Salt 1.00 0.097 Guar Gum 0.50 0.048 Flavor Chem.", "Dark Chocolate Flavor 0.40 0.039 1035.36 100.000 Procedures: 1.Mix the corn CAF and the corn BFG with the evaporated milk until smooth.", "2.Add NFDM, Skim Milk, Salt, and sugar.", "3.Add Guar Gum, Mix with high Speed mixer (food processor).", "4.Heat to 150° F. slowly; adding the Chocolate with the continuous stirring.", "5.Add remaining flavors.", "(B) Pita Chips Quantity Item (g) Percentage Yeast 7.09 0.50 Water, Warm 226.80 15.96 Sugar 4.40 0.31 Bread Flour 569.00 40.05 Whole Wheat Flour 300.00 21.12 Corn CAF 8.50 0.60 Corn BFG 24.00 1.69 Salt 6.50 0.46 Sugar 4.00 0.28 Water 215.00 15.13 Olive Oil 55.32 3.89 1420.61 100.00 After Bake Baste: Olive Oil 227.00 Black Pepper 2.00 Garlic 4.00 Basil 0.50 NOTES: Bake: Disk 450° F. 3 Minutes/Side Dry Baking 250° F. 50 Minutes CAF is used to improve structure, reduce breakage and to manage moisture through processing.", "TABLE 16 The product formulation by mixing corn CAF and corn BFC as shown in above tables defines functional blends of the two that can seamlessly displace either hydrocolloids and provide for clean label.", "The compositions are summarized below as they constitute technical basis for production and sale of commercial blends.", "Corn BFG and corn Percent Consumer CAF Ratio Product Ratio of Example (g/g) Blends Nutrition Bar 5.87/1.97 74.68/24.94 Pita Chip 73.80/26.20 73.80/26.20 Nutrition Drink 3.95/0.39 91.01/8.99 Cheese Sauce 2.69/0.76 77.97/22.03 Alfredo Sauce 0.62/1.22 37.70/66.30 Ranch Dressing 0.3003/2.003 11.03/86.97 Chocolate Pudding 0.193/2.489 7.20/92.80" ] ]
Patent_15874167
[ [ "Providing a Downlink Control Structure in a First Carrier to Indicate Information in a Second Different Carrier", "A mobile station receives a downlink control structure in a first carrier, where the downlink control structure indicates that control information for the mobile station is on a second, different carrier.", "The mobile station decodes the control information in the second carrier, where the control information specifies resource allocation of a wireless link for the mobile station.", "More specifically, according to some implementations, the control channel in the first carrier specifies the resource allocation for an extended control channel in the second carrier, where the extended control channel specifies the resource allocation for traffic data of a wireless link for the mobile station." ], [ "1.-20.", "(canceled) 21.A base station, comprising: wireless communication circuitry, configured to perform wireless communication with at least a mobile station; and processing hardware coupled to the wireless communication circuitry, wherein the processing hardware is configured to operate with the wireless communication circuitry to: transmit, to a mobile station, control information in resource blocks (RBs) of a physical downlink shared channel region on a first component carrier among a plurality of component carriers, wherein the plurality of component carriers comprises the first component carrier and a second component carrier, wherein the physical downlink shared channel region is located within orthogonal frequency division multiplexing (OFDM) symbols following the physical downlink control channel region in a subframe, wherein the second component carrier is different than the first component carrier, wherein the control information indicates a resource assignment for the mobile station on the second component carrier, and wherein the second carrier is identified in the control information of the first component carrier by a component carrier number; and communicate with the mobile station using the control information of the first component carrier and the resource assignment on the second component carrier.", "22.The base station of claim 21, wherein the processing hardware is further configured to operate with the wireless communication circuitry to: transmit, to the mobile station, higher layer signaling indicating information for locating control information on at least the first component carrier among the plurality of component carriers.", "23.The base station of claim 21, wherein each component carrier among the plurality of component carriers appears as a Long-Term Evolution (LTE) carrier.", "24.The base station of claim 21, wherein each component carrier among the plurality of component carriers has a separate physical downlink control channel (PDCCH), physical control format indicator channel (PCFICH), and physical hybrid automatic repeat request indicator channel (PHICH).", "25.The base station of claim 21, wherein to communicate with the mobile station, the processing hardware is further configured to operate with the wireless communication circuitry to: transmit data to the mobile station using both the first carrier and the second carrier.", "26.The base station of claim 21, wherein the processing hardware is further configured to operate with the wireless communication circuitry to: communicate with the wireless station to establish carrier aggregation of the plurality of carriers for the mobile station.", "27.The base station of claim 21, wherein the first and second carriers are non-contiguous.", "28.The base station of claim 21, wherein the RBs are divided into resource element groups (REGs) and control channel elements (CCEs) that are configured for signaling to a plurality of mobile stations.", "29.The base station of claim 21, wherein the processing hardware is further configured to operate with the wireless communication circuitry to transmit a downlink control structure to the mobile station that indicates that the control information is on the first carrier; wherein transmitting the control information is based on the downlink control structure.", "30.A non-transitory, computer accessible memory medium storing program instructions executable by a processor of a base station to: generate instructions to transmit, to a mobile station, control information in resource blocks (RBs) of a physical downlink shared channel region on a first component carrier among a plurality of component carriers, wherein the plurality of component carriers comprises the first component carrier and a second component carrier, wherein the physical downlink shared channel region is located within orthogonal frequency division multiplexing (OFDM) symbols following the physical downlink control channel region in a subframe, wherein the second component carrier is different than the first component carrier, wherein the control information indicates a resource assignment for the mobile station on the second component carrier, and wherein the second carrier is identified in the control information of the first component carrier by a component carrier number; and communicate with the mobile station using the control information of the first component carrier and the resource assignment on the second component carrier.", "31.The non-transitory, computer accessible memory medium of claim 30, wherein the program instructions are further executable to generate instructions to: transmit, to the mobile station, higher layer signaling indicating information for locating control information on at least the first component carrier among the plurality of component carriers.", "32.The non-transitory, computer accessible memory medium of claim 30, wherein each component carrier among the plurality of component carriers appears as a Long-Term Evolution (LTE) carrier.", "33.The non-transitory, computer accessible memory medium of claim 30, wherein each component carrier among the plurality of component carriers has a separate physical downlink control channel (PDCCH), physical control format indicator channel (PCFICH), and physical hybrid automatic repeat request indicator channel (PHICH).", "34.The non-transitory, computer accessible memory medium of claim 30, wherein to communicate with the mobile station, the program instructions are further executable to: generate instructions to transmit data to the mobile station using both the first carrier and the second carrier.", "35.The non-transitory, computer accessible memory medium of claim 30, wherein the program instructions are further executable to: communicate with the mobile station to establish carrier aggregation of the plurality of carriers for the mobile station.", "36.A method for wireless communication, comprising: a base station, transmitting, to a mobile station, control information in resource blocks (RBs) of a physical downlink shared channel region on a first component carrier among a plurality of component carriers, wherein the plurality of component carriers comprises the first component carrier and a second component carrier, wherein the physical downlink shared channel region is located within orthogonal frequency division multiplexing (OFDM) symbols following the physical downlink control channel region in a subframe, wherein the second component carrier is different than the first component carrier, wherein the control information indicates a resource assignment for the mobile station on the second component carrier, and wherein the second carrier is identified in the control information of the first component carrier by a component carrier number; and performing communication with the mobile station using the control information of the first component carrier and the resource assignment on the second component carrier.", "37.The method of claim 36, further comprising: the base station, transmitting, to the mobile station, higher layer signaling indicating information for locating control information on at least the first component carrier among the plurality of component carriers.", "38.The method of claim 36, wherein each component carrier among the plurality of component carriers appears as a Long-Term Evolution (LTE) carrier.", "39.The method of claim 36, wherein each component carrier among the plurality of component carriers has a separate physical downlink control channel (PDCCH), physical control format indicator channel (PCFICH), and physical hybrid automatic repeat request indicator channel (PHICH).", "40.The method of claim 36, wherein the RBs are divided into resource element groups (REGs) and control channel elements (CCEs) that are configured for signaling to a plurality mobile stations." ], [ "<SOH> BACKGROUND <EOH>Various wireless access technologies have been proposed or implemented to enable mobile stations to perform communications with other mobile stations or with wired terminals coupled to wired networks.", "Examples of wireless access technologies include GSM (Global System for Mobile communications) and UMTS (Universal Mobile Telecommunications System) technologies, defined by the Third Generation Partnership Project (3GPP); and CDMA 2000 (Code Division Multiple Access 2000) technologies, defined by 3GPP2.As part of the continuing evolution of wireless access technologies to improve spectral efficiency, to improve services, to lower costs, and so forth, new standards have been proposed.", "One such new standard is the Long Term Evolution (LTE) standard from 3GPP, which seeks to enhance the UMTS technology.", "The LTE standard is also referred to as the EUTRA (Evolved Universal Terrestrial Radio Access) standard.", "More recent developments of LTE have proposed the use of multiple component carriers to increase the available bandwidth of wireless communications.", "Each component carrier can have a frequency bandwidth of up to 20 megahertz (MHz).", "Multiple component carriers are aggregated together to increase the overall bandwidth available to user equipment.", "Each component carrier appears as an LTE carrier to a mobile station.", "An issue associated with using multiple component carriers is that a mobile station may have to perform blind decoding of PDCCH (physical downlink control channel) in multiple component carriers to find relevant control information for the mobile station.", "Such blind decoding may cause wasteful power consumption at the mobile station." ], [ "<SOH> SUMMARY <EOH>In general, according to an embodiment, a method for wireless communication comprises receiving, by a mobile station, a downlink control structure in a first carrier, where the downlink control structure indicates that control information for the mobile station is on a second, different carrier.", "The mobile station decodes the control information on the second carrier, where the control information specifies resource allocation of a wireless link for the mobile station.", "Other or alternative features will become apparent from the following description, from the drawings, and from the claims." ], [ "BACKGROUND Various wireless access technologies have been proposed or implemented to enable mobile stations to perform communications with other mobile stations or with wired terminals coupled to wired networks.", "Examples of wireless access technologies include GSM (Global System for Mobile communications) and UMTS (Universal Mobile Telecommunications System) technologies, defined by the Third Generation Partnership Project (3GPP); and CDMA 2000 (Code Division Multiple Access 2000) technologies, defined by 3GPP2.As part of the continuing evolution of wireless access technologies to improve spectral efficiency, to improve services, to lower costs, and so forth, new standards have been proposed.", "One such new standard is the Long Term Evolution (LTE) standard from 3GPP, which seeks to enhance the UMTS technology.", "The LTE standard is also referred to as the EUTRA (Evolved Universal Terrestrial Radio Access) standard.", "More recent developments of LTE have proposed the use of multiple component carriers to increase the available bandwidth of wireless communications.", "Each component carrier can have a frequency bandwidth of up to 20 megahertz (MHz).", "Multiple component carriers are aggregated together to increase the overall bandwidth available to user equipment.", "Each component carrier appears as an LTE carrier to a mobile station.", "An issue associated with using multiple component carriers is that a mobile station may have to perform blind decoding of PDCCH (physical downlink control channel) in multiple component carriers to find relevant control information for the mobile station.", "Such blind decoding may cause wasteful power consumption at the mobile station.", "SUMMARY In general, according to an embodiment, a method for wireless communication comprises receiving, by a mobile station, a downlink control structure in a first carrier, where the downlink control structure indicates that control information for the mobile station is on a second, different carrier.", "The mobile station decodes the control information on the second carrier, where the control information specifies resource allocation of a wireless link for the mobile station.", "Other or alternative features will become apparent from the following description, from the drawings, and from the claims.", "BRIEF DESCRIPTION OF THE DRAWINGS Some embodiments of the invention are described with respect to the following figures: FIG.", "1 is a block diagram of an example communications network that incorporates an embodiment of the invention; FIG.", "2 illustrates an example frame structure that incorporates a legacy physical downlink control channel (PDCCH) and an extended PDCCH (E-PDCCH), according to an embodiment; FIG.", "3 illustrates an example in which a PDCCH in one carrier points to multiple E-PDCCHs in multiple carriers, in accordance with an embodiment; FIG.", "4 illustrates a PDCCH in one carrier that points to a single E-PDCCH in another carrier, according to another embodiment; FIG.", "5 illustrates an arrangement in which a carrier pointer message in one carrier points to control information in multiple carriers, according to a further embodiment; and FIG.", "6 is a flow diagram of the process of obtaining control information by a mobile station, according to an embodiment.", "DETAILED DESCRIPTION In accordance with some preferred embodiments, a technique or mechanism is provided in which a downlink control structure is provided in a first carrier, where the downlink control structure indicates that control information for a mobile station is on a second, different carrier.", "The downlink control structure can identify a location of the control information on the second carrier, and the downlink control structure can also specify the size of the control information on the second carrier.", "Multiple different carriers, including the first and second carriers, are aggregated to provide an overall bandwidth for wireless communications that is larger than the bandwidth provided by any of the individual carriers.", "The mobile station decodes the control information on the second carrier, where the control information specifies resource allocation (and other control-related aspects) of a wireless link for the mobile station.", "In accordance with some embodiments, the wireless communications technology that is used is according to the Long Term Evolution (LTE) or EUTRA (Evolved Universal Terrestrial Radio Access) standard from 3GPP (Third Generation Partnership Project), which is an enhancement of the UMTS (Universal Mobile Telecommunications System) wireless technology.", "Reference to an LTE (or EUTRA) wireless communications network refers to the wireless communications network that conforms to the requirements of the LTE (or EUTRA) standard developed by 3GPP, as that standard currently exists or as the standard evolves over time.", "Note that LTE (or EUTRA) can refer to the current LTE (or EUTRA) standard, or to modifications of the LTE (or EUTRA) standard that are made over time.", "It is expected that in the future a standard that has evolved from LTE (or EUTRA) may be referred to by another name.", "It is contemplated that the term “LTE” or “EUTRA” as used herein is intended to cover such future standards as well.", "In alternative embodiments, wireless communications technologies according to other standards can be employed.", "In the LTE context, the downlink control structure in a first carrier that points to control information in at least a second carrier is in a portion of a legacy PDCCH (physical downlink control channel) region.", "The legacy PDCCH region could be the first few OFDM (orthogonal frequency division multiplex) symbols of an LTE Release 8 subframe that are used for transmission of PDCCHs.", "In some embodiments, the portion of the legacy PDCCH region containing the downlink control structure has a predefined compact DCI (downlink control information) format.", "The control information in the second carrier can be in the form of an extended PDCCH (E-PDCCH).", "The mobile station decodes the E-PDCCH to obtain resource allocations (and other control information) for the mobile station.", "The downlink control structure in the legacy PDCCH region is also referred to as the primary PDCCH, and the primary PDCCH is carried in an anchor carrier that a given mobile station monitors for obtaining control information.", "Based on detecting the primary PDCCH, the mobile station can easily identify another carrier that contains the E-PDCCH, which the mobile station can then decode to obtain additional control information, including resource allocation, information indicating a modulation and coding scheme (MCS) (to specify the modulation and coding to apply to traffic data), information relating to a HARQ (hybrid automatic repeat request) process (which specifies the addition of error correction information to a message for error detection and correction), information relating to a redundancy version (RV) (which is an HARQ parameter used with incremental redundancy to inform which retransmission version is used), power control information, and/or other control information.", "Legacy PDCCH can also be carried by other carriers to support legacy mobile stations.", "FIG.", "1 shows an example wireless network in which some embodiments of the invention can be provided.", "The wireless network includes a base station 100 that includes an antenna array or other antenna assembly 102 for sending wireless signals into a cell sector 108.A cell sector is one section of a cell of a cellular network.", "In alternative implementations, element 108 can represent an entire cell.", "More generally, a “cell segment” refers to either a cell or a cell sector.", "Although just one base station is depicted in FIG.", "1, it is noted that a wireless network would typically include multiple base stations.", "In some embodiments, the wireless network is an LTE wireless network.", "In an LTE wireless network, the base station 100 is an enhanced node B (“eNode B”), which includes a base transceiver station that includes the antenna array 102.The base station 100 may also include a radio network controller that cooperates with the enhanced node B.", "The radio network controller and/or enhanced node B can perform one or more of the following tasks: radio resource management, mobility management for managing mobility of mobile stations, routing of traffic, and so forth.", "Note that one radio network controller can access multiple eNode Bs, or alternatively, an eNode B can be accessed by more than one radio access controller.", "More generally, the term “base station” can refer to a cellular network base station, an access point used in any type of wireless network, or any type of wireless transmitter to communicate with mobile stations.", "As depicted in FIG.", "1, the base station 100 includes one or more central processing units (CPUs) 122, which is (are) connected to storage 124.Moreover, the base station 100 includes software 126 that is executable on the CPU(s) 122 to perform tasks of the base station 100.The mobile station 110 of FIG.", "1 also includes one or more CPUs 130 that are connected to storage 132.The mobile station 110 also includes software 134 that is executable on the CPU(s) 130 to perform tasks of the mobile station 110.In addition, the mobile station 110 includes an interface 131 to communicate wirelessly with the base station 100.The base station 100 is connected to a serving and/or packet data network (PDN) gateway 112, which terminates the user plane interface toward the enhanced node B and assumes the responsibility for packet routing and transfer towards an external network 114, which can be a packet data network such as the Internet or other type of network.", "The arrangement depicted in FIG.", "1 is provided for purposes of example.", "In other implementations, other wireless network arrangements are used.", "As noted above, an advanced version of the LTE standard has proposed performing carrier aggregation to provide a larger bandwidth.", "Typically, an LTE component carrier (or more simply “carrier”) supports bandwidth up to 20 megahertz (MHz).", "However, by aggregating multiple carriers together, a larger overall bandwidth can be provided for wireless communications with mobile stations by a base station.", "The aggregated carriers can be contiguous carriers, or alternatively, the aggregated carriers do not have to be contiguous.", "Note that LTE-advanced mobile stations are able to employ aggregated carriers for performing wireless communications with base stations.", "Legacy LTE mobile stations are only able to employ one carrier.", "FIG.", "2 shows a frame structure 200 on a particular LTE carrier.", "The horizontal axis of the frame structure 200 represents the time dimension (time slots), while the vertical axis of the frame structure 200 represents the frequency dimension (subcarriers of different frequencies).", "The frame structure 200 includes a first region 202 that contains various control information, including the legacy (primary) PDCCH.", "In addition to legacy PDCCHs, the region 202 could include one or multiple primary PDCCHs.", "Each primary PDCCH provides the control information for one mobile station or a group of mobile stations.", "In addition, in the example of FIG.", "2, the region 202 also includes a physical control format indicator channel (PCFICH) and a physical hybrid automatic repeat request indicator channel (PHICH).", "In other implementations, the region 202 can include other types of control channels.", "In accordance with some embodiments, the frame structure 200 also includes another region 204 that includes the E-PDCCH that contains additional control information.", "The region 204 may include one or multiple E-PDCCHs.", "Each E-PDCCH is to provide additional control information for one mobile station or a group of mobile stations.", "A primary PDCCH on another carrier can identify the location and size of the E-PDCCH in the region 204 of the frame structure 200.Similarly, the primary PDCCH in the region 202 of the frame structure 200 can identify the location and size of an E-PDCCH on another carrier.", "Since the primary PDCCH informs the mobile station the location and size of the E-PDCCH on another carrier, the mobile station is able to decode the E-PDCCH without blind decoding.", "The primary PDCCH could also be used to indicate the E-PDCCH on the same carrier.", "FIGS.", "3 and 4 depict two alternative embodiments of implementing the primary PDCCH and E-PDCCH.", "In the FIG.", "3 embodiment, a particular primary PDCCH (e.g., primary PDCCH 302 in a frame structure 200B) on a first carrier can refer to multiple E-PDCCHs 306A, 306B, 306C, in respective E-PDCCH regions 304A, 304B, and 304C of respective frame structures 200A, 200B, 200C that are carried in corresponding carriers.", "Specifically, the primary PDCCH 302 can identify the location and size of the E-PDCCH 306A, identify the location and size of the second E-PDCCH 306B, and identify the location and size of the E-PDCCH 306C.", "Each of the E-PDCCHs 306A, 306B, and 306C is identified by a carrier number, location information, and size information.", "In one example, the primary PDCCH can have the following format: {Carrier #1, E-PDCCH location and size in E-PDCCH region; Carrier #2, E-PDCCH location and size in E-PDCCH region; .", ".", ".", "Carrier #M, E-PDCCH location and size in E-PDCCH region}; where M is the number of carriers supported by the system, or the number of carriers supported/configured by the base station.", "With this option, a separate E-PDCCH is provided per component carrier, such that each E-PDCCH indicates the resource assignment on the corresponding individual carrier.", "FIG.", "4 shows another option, in which the primary PDCCH 302 on one carrier (carrying frame structure 200B) points to only one E-PDCCH 306C in another (or the same) carrier.", "The format of the primary PDCCH in this example is as follows: {Carrier ID, E-PDCCH location and size in E-PDCCH region} In this example, the primary PDDCH points the mobile station to the E-PDCCH in just one carrier.", "The E-PDCCH on this carrier indicates the resource assignment across all carriers (i.e., one joint E-PDCCH for all carriers).", "To save the mobile power consumption, the mobile station typically monitors an anchor carrier.", "When the mobile station detects the primary PDCCH on the anchor carrier, the mobile station turns on its transceivers on non-anchor carriers and further detects the E-PDCCHs on multiple carriers.", "To accommodate the transition time for the mobile station to turn on the transceivers, the E-PDCCHs could be in a subframe which is a few subframes later than the subframe containing the primary PDCCH.", "To allow for the mobile station to know the resource allocation (location and size) of an E-PDCCH region, one of several options can be used.", "In a first option, the location of the starting resource block (RB) and the number of RBs of the E-PDCCH region is indicated.", "In the case where distributed virtual RB (DVRB) is used, in which case the RBs that are allocated are not contiguous, then a gap value can also be specified.", "In a second option, the number of RBs of the E-PDCCH region can be specified; however, the starting RB is not explicitly specified.", "The mobile station finds the starting RB location of the E-PDCCH region using a predefined frequency hopping pattern that can be a function of a cell identifier and a subframe index.", "An LTE subframe is a portion of an LTE frame, where an LTE frame has a predefined overall time length that is divided into a predefined number of time slots.", "An LTE frame is made up of multiple subframes, where an LTE subframe can include some predefined number of the time slots (e.g., two slots) of the LTE frame.", "The subframe index identifies the particular subframe within the overall frame.", "For the base station 100 (FIG.", "1) to signal to the mobile station the resource allocation of the E-PDCCH region, several options can be used.", "In a first option, a predefined DCI format is defined to indicate the resource allocation of the E-PDCCH region on each component carrier.", "This predefined DCI format is provided in the legacy PDCCH region.", "Also, the CRC (cyclic redundancy check) of the predefined DCI format can be scrambled using a predefined RNTI (radio network temporary identifier) such that only LTE-advanced mobile stations with LTE-advanced multi-carrier capability are able to decode the predefined DCI format.", "In some implementations, this predefined RNTI is referred to as LTE-A-RNTI.", "In other implementations, other scrambling schemes or coding schemes can be applied to specify the predefined DCI format such that only LTE-advanced mobile stations that have multi-carrier capability can decode the predefined DCI format.", "Note that a legacy LTE mobile station that does not support multiple carriers would not be able to decode this predefined DCI format.", "In a different option, the base station 100 can use higher layer signaling, such as RRC (radio resource control) signaling, SIB (system information block) signaling, and so forth, to carry the resource allocation of the E-PDCCH region on each component carrier.", "FIG.", "5 illustrates an embodiment different from the FIG.", "3 and FIG.", "4 embodiments, in which a carrier pointer message 502 is provided in a legacy PDCCH region that is on the anchor carrier 504 for the mobile station 110.The carrier pointer message in the anchor carrier 504 indicates to the mobile station 110 the non-anchor carrier (e.g., carrier 506) that the mobile station needs to monitor the PDCCH.", "Usually, the mobile station would monitor its anchor carrier only.", "When there are resource allocations on non-anchor carrier(s), the base station 100 sends a carrier pointer message (such as the carrier pointer message 502 on the PDCCH of the anchor carrier 504), which is decoded by the mobile station such that the mobile station can monitor the PDCCH of the non-anchor carrier(s), such as non-anchor carrier 506, in the next subframe.", "The carrier pointer message can also be used to indicate the mobile station to monitor the PDCCHs on both anchor and non-anchor carriers.", "Although FIG.", "5 shows a one subframe delay between the carrier pointer message 502 and decoding of PDCCH on a non-anchor carrier, a different embodiment may allow the mobile station 110 to decode the PDCCH on the non-anchor carrier in the same subframe.", "Some benefits may be provided by some embodiments of the invention.", "The downlink control structure can be used for both contiguous and non-contiguous spectrum aggregation.", "To save power, the mobile station monitors the downlink control structure of its anchor carrier only, and turns on other component carriers as necessary.", "There is limited blind decoding by a mobile station, and no blind decoding for E-PDCCH due to explicit signaling of location and size of E-PDCCH.", "With E-PDCCH, it is convenient to support new DCI formats for LTE-advanced features of relatively large payload size.", "Also, the new compact DCI format of the primary PDCCH used to indicate the E-PDCCH is not expected to have a large payload size, such that it should not overload the legacy PDCCH region.", "The E-PDCCH may achieve better performance than legacy PDCCH, since inter-cell interference can be better controlled on E-PDCCH as it is easier to avoid E-PDCCH collision from neighboring cells.", "The E-PDCCH provides control information over the physical downlink shared channel (PDSCH), which is a downlink traffic channel from the base station to the mobile station.", "The information format of the E-PDCCH can be as follows.", "The E-PDCCH can include a component carrier number (to identify the associated carrier), resource allocation for data, MCS information, HARQ process information, uplink power control information, and other control information.", "The reserved resource blocks (RBs) of the E-PDCCH can be divided into resource element groups (REGs) and control channel elements (CCEs) that can be used for signaling to different mobile stations.", "The compact DCI format of the primary PDCCH carries information on the REGs and/or CCEs to be used by mobile stations.", "An index to the starting REG and the length of the allocated REGs are specified.", "The index can be a physical REG index or a logical REG index.", "In the case of the logical REG index, the mapping of logical to physical REGs can be determined through a random permutation that can be a function of the cell identifier.", "FIG.", "6 is a flow diagram of a process of wireless communications according to an embodiment.", "The tasks of FIG.", "6 can be performed by a mobile station.", "The mobile station receives (at 602) a downlink control structure in a primary control channel in the legacy PDCCH region in a first carrier.", "The downlink control structure identifies the location and size of extended control information on at least a second different carrier.", "The mobile station decodes (at 604) the downlink control structure to find the extended control information, such as the E-PDCCH.", "The extended control information on the second carrier is decoded (at 606) by the mobile station, such that the mobile station is able to retrieve the control information to be used by the mobile station for performing wireless communications.", "Instructions of software described above (including software 126 and 134 of FIG.", "1) are loaded for execution on a processor (such as one or more CPUs 122 and 130 in FIG.", "1).", "The processor includes microprocessors, microcontrollers, processor modules or subsystems (including one or more microprocessors or microcontrollers), or other control or computing devices.", "As used here, a “processor” can refer to a single component or to plural components (e.g., one CPU or multiple CPUs).", "Data and instructions (of the software) are stored in respective storage devices, which are implemented as one or more computer-readable or computer-usable storage media.", "The storage media include different forms of memory including semiconductor memory devices such as dynamic or static random access memories (DRAMs or SRAMs), erasable and programmable read-only memories (EPROMs), electrically erasable and programmable read-only memories (EEPROMs) and flash memories; magnetic disks such as fixed, floppy and removable disks; other magnetic media including tape; and optical media such as compact disks (CDs) or digital video disks (DVDs).", "Note that the instructions of the software discussed above can be provided on one computer-readable or computer-usable storage medium, or alternatively, can be provided on multiple computer-readable or computer-usable storage media distributed in a large system having possibly plural nodes.", "Such computer-readable or computer-usable storage medium or media is (are) considered to be part of an article (or article of manufacture).", "An article or article of manufacture can refer to any manufactured single component or multiple components.", "In the foregoing description, numerous details are set forth to provide an understanding of the present invention.", "However, it will be understood by those skilled in the art that the present invention may be practiced without these details.", "While the invention has been disclosed with respect to a limited number of embodiments, those skilled in the art will appreciate numerous modifications and variations therefrom.", "It is intended that the appended claims cover such modifications and variations as fall within the true spirit and scope of the invention." ] ]
Patent_15874176
[ [ "RETROACTIVE MESSAGING FOR HANDLING MISSED SYNCHRONIZATION EVENTS", "Various arrangements for handling delayed status update are presented.", "A network-enabled sensor unit may be used to measure an environmental condition.", "The sensor unit may determine, based on measuring the environmental condition, an environmental condition status has changed state.", "A network connection may be established that permits communication with a remote notification service system.", "This notification service system may maintain a remote status intended to be synchronized with the environmental condition status of the sensor unit.", "The sensor unit may determine that the environmental condition status has changed prior to communicating the environmental condition status to the notification service system.", "A historical status array may be transmitted to the notification service system in response to determining the environmental condition status has reverted to the first state prior to communicating the environmental condition status.", "The historical status array can indicate previous states of the environmental condition status of the sensor unit." ], [ "1.A method for providing a missed notification, the method comprising: maintaining, by a notification service server system, remote environmental condition status information for a plurality of network-enabled environmental sensor units; receiving, by the notification service server system, a historical status array from a network-enabled environmental sensor unit of the plurality of the network-enabled environmental sensor units, wherein the historical status array indicates one or more previous states of an environmental condition status of the network-enabled sensor unit; analyzing, by the notification service server system, the received historical status array; determining, by the notification service server system, that a missed notification is to be output, wherein the missed notification is indicative of: 1) a current condition status being detected by the network-enabled environmental sensor unit, and 2) that a second condition status was previously detected by the network-enabled environmental sensor; and transmitting, by the notification service server system, to a remote user device, the missed notification.", "2.The method for providing the missed notification of claim 1, wherein analyzing the received historical status array comprises: determining that the most recent state indicated in the historical status array is a standby state; and determining that one or more previous states indicated in the historical status array have not yet been synchronized with the notification service server system.", "3.The method for providing the missed notification of claim 1, wherein the missed notification is transmitted to the remote user device as a push notification.", "4.The method for providing the missed notification of claim 1, further comprising: presenting, by the remote user device, the missed notification.", "5.The method for providing the missed notification of claim 1, wherein determining that the missed notification is to be output is performed is based on an outcome of analyzing the received historical status array.", "6.The method for providing the missed notification of claim 1, further comprising: measuring, by the network-enabled sensor unit, an environmental condition; determining, by the network-enabled sensor unit, based on measuring the environmental condition, the environmental condition status has changed from a first state to a second state; and establishing a network connection that permits communication with the notification service server system in response to determining the environmental condition status has changed.", "7.The method for providing the missed notification of claim 6, further comprising: determining, by the network-enabled sensor unit, the environmental condition status has reverted to the first state prior to communicating the environmental condition status to the notification service server system via the established network connection.", "8.The method for providing the missed notification of claim 7, further comprising: transmitting, by the network-enabled sensor unit, the historical status array to the notification service server system via the established network connection in response to determining the environmental condition status has reverted to the first state prior to communicating the environmental condition status to the notification service server system.", "9.A system for providing a missed notification, the system comprising: a notification service server system, comprising: one or more processors; and a memory communicatively coupled with and readable by the one or more processors and having stored therein processor-readable instructions which, when executed by the one or more processors, cause the one or more processors to: maintain remote environmental condition status information for a plurality of network-enabled environmental sensor units; receive a historical status array from a network-enabled environmental sensor unit of the plurality of the network-enabled environmental sensor units, wherein the historical status array indicates one or more previous states of an environmental condition status of the network-enabled sensor unit; analyze the received historical status array from the network-enabled environmental sensor unit; determine that a missed notification is to be output, wherein the missed notification is indicative of: 1) a current condition status being detected by the network-enabled sensor unit, and 2) that a second condition status was previously detected; and cause the missed notification to be transmitted to a user device.", "10.The system for providing the missed notification of claim 9, wherein analyzing the received historical status array comprises processor-readable instructions which, when executed, cause the one or more processors to: determine that the most recent state indicated in the historical status array is a standby state; and determine that one or more previous states indicated in the historical status array have not yet been synchronized with the notification service server system.", "11.The system for providing the missed notification of claim 9, wherein the missed notification is transmitted by the notification service server system to the user device as a push notification.", "12.The system for providing the missed notification of claim 9, wherein the system further comprises the network-enabled environmental sensor unit, comprising: a network interface; one or more environmental sensors; one or more processors; and a memory communicatively coupled with and readable by the one or more processors and having stored therein processor-readable instructions which, when executed by the one or more processors, cause the one or more processors to: determine an environmental condition using the one or more environmental sensors; determine, based on measuring the environmental condition, the environmental condition status has changed from a first state to a second state; and establish a network connection that permits communication with the notification service server system in response to determining the environmental condition status has changed.", "13.The system for providing the missed notification of claim 12, wherein the processor-readable instructions of the network-enabled sensor unit, when executed, further cause the one or more processors of the network-enabled sensor unit to: determine that the environmental condition status has reverted to the first state prior to communicating the environmental condition status to the notification service server system via the established network connection.", "14.The system for providing the missed notification of claim 13, wherein the processor-readable instructions of the network-enabled sensor unit, when executed, further cause the one or more processors of the network-enabled sensor unit to: cause the historical status array to be transmitted to the notification service server system via the established network connection in response to determining the environmental condition status has reverted to the first state prior to communicating the environmental condition status to the notification service server system.", "15.A method for handling a delayed status update, the method comprising: measuring, by a network-enabled sensor unit, a condition; determining, by the network-enabled sensor unit, based on measuring the condition, a condition status has changed from a first state to a second state; establishing a network connection that permits communication with a notification service server system in response to determining the condition status has changed; determining, by the network-enabled sensor unit, the condition status has reverted to the first state prior to communicating the condition status to the notification service server system via the established network connection; and transmitting, by the network-enabled sensor unit, historical status data to the notification service server system via the established network connection in response to determining the condition status has reverted to the first state prior to communicating the condition status to the notification service server system, wherein: the historical status data indicates one or more previous states of the condition status determined by the network-enabled sensor unit.", "16.The method for handling the delayed status update of claim 15, further comprising: determining, by the network-enabled sensor unit, an amount of time that has elapsed between determining the condition status has changed from the first state to the second state and the network connection being established; and comparing, by the network-enabled sensor unit, the determined amount of time with a stored threshold amount of time; wherein: transmitting the historical status data to the notification service server system is contingent on comparing the determined amount of time to the stored threshold amount of time.", "17.The method for handling the delayed status update of claim 16, further comprising parsing, by the notification service server system, the transmitted historical status data to analyze the one or more previous states of the condition status of the network-enabled sensor unit.", "18.The method for handling the delayed status update of claim 17, further comprising: determining, by the notification service server system, based on parsing the historical status data, to transmit a user notification indicative of the condition; accessing, by the notification service server system, a database that links a user device with the network-enabled sensor unit; and causing, by the notification service server system, a notification to be transmitted to the user device indicative of the condition.", "19.The method for handling the delayed status update of claim 18, wherein the notification is a push notification and the user device is a cellular telephone, the push notification being transmitted to the user device without a request having been sent from the user device to the notification service server system.", "20.The method for handling the delayed status update of claim 15, wherein the condition measured is selected from the group consisting of: an amount of carbon monoxide; and an amount of smoke.", "21.A system for handling a delayed status update, the system comprising: a network-enabled sensor unit, comprising: a wireless network interface; one or more processors; and a memory communicatively coupled with and readable by the one or more processors and having stored therein processor-readable instructions which, when executed by the one or more processors, cause the one or more processors to: determine a condition; determine, based on the condition, a condition status has changed from a first state to a second state; establish a network connection that permits communication with a notification service server system in response to determining the condition status has changed; determine the condition status has reverted to the first state prior to communicating the condition status to the notification service server system via the established network connection; and transmit historical status data to the notification service server system via the established network connection in response to determining the condition status has reverted to the first state prior to communicating the condition status to the notification service server system, wherein: the historical status data indicates one or more previous states of the condition status determined by the network-enabled sensor unit.", "22.The system for handling the delayed status update of claim 21, wherein the processor-readable instructions, when executed, further cause the one or more processors to: determine an amount of time that has elapsed between determining the condition status has changed from the first state to the second state and the network connection being established; and compare the determined amount of time with a stored threshold amount of time; wherein: transmitting the historical status data to the notification service server system is contingent on comparing the determined amount of time to the stored threshold amount of time.", "23.The system for handling the delayed status update of claim 22, wherein the system further comprises the notification service server system, the notification service server system being configured to analyze the one or more previous states of the condition status of the network-enabled sensor unit indicated in the historical status data.", "24.The system for handling the delayed status update of claim 23, wherein the notification service server system is further configured to: determine based on parsing the historical status data, to transmit a user notification indicative of the condition; access a database that links a user device with the network-enabled sensor unit; and cause a notification to be transmitted to the user device indicative of the condition.", "25.The system for handling the delayed status update of claim 24, wherein the notification is a push notification.", "26.The system for handling the delayed status update claim 21, wherein the condition measured is selected from the group consisting of: an amount of carbon monoxide; and an amount of smoke." ], [ "<SOH> BACKGROUND <EOH>Smart devices, including sensor devices, that communicate over network connections are becoming commonplace.", "With such smart devices, a user can receive information from and about the smart device on a separate user device via a network connection.", "For instance, while a user is away from home, the user may receive information collected by a smart device located at the user's home via his cellular phone.", "While smart devices can provide a user with useful information, smart devices are typically dependent on a network connection being present to enable communication between the smart device, a server system, and/or a user device.", "If the network connection is not available, it may not be possible for information to be sent from the smart device to a server system which can then relay information to the user device.", "As such, in some circumstances, a user may expect to receive information from a smart device, but such information may never be delivered due to a period of time when the network connection was not available to the smart device." ], [ "<SOH> SUMMARY <EOH>Various arrangements for handing a delayed status update are detailed herein.", "In some embodiments, a method for handling a delayed status update is presented.", "The method may include measuring, by a network-enabled sensor unit, an environmental condition.", "The method may include determining, by the network-enabled sensor unit, based on measuring the environmental condition, an environmental condition status has changed from a first state to a second state.", "The method may include establishing a network connection that permits communication with a notification service system in response to determining the environmental condition status has changed.", "The notification service system may maintain a remote environmental condition status to be synchronized with the environmental condition status of the network-enabled sensor unit.", "The method may include determining, by the network-enabled sensor unit, the environmental condition status has reverted to the first state prior to communicating the environmental condition status to the notification service system via the established network connection.", "The method may include transmitting, by the network-enabled sensor unit, a historical status array to the notification service system via the established network connection in response to determining the environmental condition status has reverted to the first state prior to communicating the environmental condition status to the notification service system.", "The historical status array may indicate one or more previous states of the environmental condition status of the network-enabled sensor unit.", "The remote environmental condition status may remain unchanged at the notification service system.", "Embodiments of such a method may include one or more of the following features: The method may include determining, by the network-enabled sensor unit, an amount of time that has elapsed between determining the environmental condition status has changed from the first state to the second state and the network connection being established.", "The method may include comparing, by the network-enabled sensor unit, the determined amount of time with a stored threshold amount of time.", "Transmitting the historical status array to the notification service system may be contingent on the determined amount of time not exceeding the stored threshold amount of time.", "The method may include parsing, by the notification service system, the transmitted historical status array to analyze the one or more previous states of the environmental condition status of the network-enabled sensor unit.", "The method may include determining, by the notification service system, based on parsing the historical status array, to transmit a user notification indicative of the environmental condition.", "The method may include accessing, by the notification service system, a database that links a user device with the network-enabled sensor unit.", "The method may include causing, by the notification service system, a notification to be transmitted to the user device indicative of the environmental condition.", "The notification may be a push notification and the user device is a cellular telephone, the push notification being transmitted to the user device without a request having been sent from the user device to the notification service system.", "The method may include broadcasting, by the network-enabled sensor unit, a message indicative of the second state via a local wireless communication protocol distinct from a protocol used for the network connection.", "The method may include receiving, by the notification service system, a suppression message from a user device associated with the network-enabled sensor unit.", "The method may include, in response to the suppression message, suppressing transmission of a notification to the user device based on parsing of the historical status array.", "The environmental condition that is measured may be an amount of smoke or an amount of carbon monoxide.", "The network-enabled sensor unit may be exclusively battery powered.", "The method may include periodically establishing, by the network-enabled sensor unit, the network connection that permits communication with the notification service system absent the environmental condition status changing.", "In some embodiments, a system for handling a delayed status update is presented.", "The system may include a network-enabled wireless unit that includes a wireless network interface, one or more processors, and a memory.", "The memory may be communicatively coupled with and readable by the one or more processors.", "The memory may have stored therein processor-readable instructions which, when executed by the one or more processors, cause the one or more processors to determine a local status has changed from a first state to a second state, wherein the local status is maintained at the network-enabled wireless unit.", "The instructions may cause the one or more processors to establish a network connection that permits communication with a notification service system in response to determining the local status has changed.", "The notification service system may maintain a remote status to be synchronized with the local status of the network-enabled wireless unit.", "The instructions may cause the one or more processors to determine the local status has changed prior to synchronization with the notification service system via the established network connection.", "The instructions may cause the one or more processors to transfer, via the wireless network interface and the established network connection, a historical status array to the notification service system in response to determining the local status has changed prior to synchronization.", "The historical status array may indicate one or more previous states of the local status of the network-enabled wireless unit.", "The remote status may remain unchanged at the notification service system.", "Embodiments of such a system may include one or more of the following features: The system may include the notification service system accessible by the network-enabled wireless unit via the network connection.", "The notification service may be configured to determine, based on parsing the historical status array, to transmit a user notification indicative of the second state.", "The notification service may be configured to access a database that links a user device with the network-enabled wireless unit.", "The notification service may be configured to transmit a notification to the user device indicative of the second state.", "The notification service may be configured to process a received suppression message from a user device associated with the network-enabled wireless unit.", "The notification service may be configured to, in response to the received suppression message, suppress transmission of a notification to the user device based on an analysis of the historical status array.", "The network-enabled wireless unit may include a local direct wireless communication interface distinct from the wireless network interface.", "The notification service may be configured to broadcast, via the local direct wireless communication interface, a message indicative of the second state.", "The system may include a mobile device.", "The mobile device may be configured to receive and process the broadcast message indicative of the second state, the broadcast message being received directly from the network-enabled wireless unit.", "The mobile device may be configured to, in response to the processed broadcast message, present an indication of the second state.", "The mobile device may be configured to, in response to the processed broadcast message, transmit a suppression message to the notification service system, wherein the suppression message instructs the notification service system to suppress notification to the user device.", "The network-enabled wireless unit may include an environmental sensor that measures an environmental condition and the local status is based on measurements made by the environmental sensor and the environmental condition is an amount of smoke or carbon monoxide.", "The network-enabled wireless unit may include a power supply, the power supply providing power to components of the network-enabled wireless unit exclusively from one or more batteries.", "The wireless device may be further configured to determine an amount of time that has elapsed between determining the local status has changed from the first state to the second state and the network connection being established.", "The wireless device may be further configured to compare the determined amount of time with a stored threshold amount of time.", "Transmitting the historical status array to the notification service system may be contingent on the determined amount of time not exceeding the stored threshold amount of time.", "In some embodiments, a non-transitory processor-readable medium is presented.", "The medium may include instructions that cause one or more processors to determine a local status has changed from a first state to a second state based on measurements from one or more environmental sensors.", "The medium may include instructions that cause one or more processors to establish a network connection that permits communication with a notification service system in response to determining the local status has changed, wherein the notification service system maintains a remote status to be synchronized with the local status.", "The medium may include instructions that cause one or more processors to determine the local status has reverted to the first state following the network connection being established but prior to synchronization with the notification service system.", "The medium may include instructions that cause one or more processors to transfer, via a wireless network interface, a historical status array to the notification service system in response to determining the local status has reverted to the first state prior to synchronization, wherein the remote status remains unchanged at the notification service system due to the local status having reverted to the first state prior to synchronization.", "In some embodiments, the medium may include instructions that cause one or more processors to determine an amount of time that has elapsed between determining the local status has changed from the first state to the second state and the network connection being established.", "The medium may include instructions that cause one or more processors to compare the determined amount of time with a stored threshold amount of time.", "Transmitting the historical status array to the notification service system may be contingent on the determined amount of time not exceeding the stored threshold amount of time." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. Non-Provisional patent application Ser.", "No.", "15/171,259, filed Jun.", "2, 2016, entitled “Retroactive Messaging for Handling Missed Synchronization Events.” The above-identified patent application is hereby incorporated by reference herein in its entirety for all purposes.", "BACKGROUND Smart devices, including sensor devices, that communicate over network connections are becoming commonplace.", "With such smart devices, a user can receive information from and about the smart device on a separate user device via a network connection.", "For instance, while a user is away from home, the user may receive information collected by a smart device located at the user's home via his cellular phone.", "While smart devices can provide a user with useful information, smart devices are typically dependent on a network connection being present to enable communication between the smart device, a server system, and/or a user device.", "If the network connection is not available, it may not be possible for information to be sent from the smart device to a server system which can then relay information to the user device.", "As such, in some circumstances, a user may expect to receive information from a smart device, but such information may never be delivered due to a period of time when the network connection was not available to the smart device.", "SUMMARY Various arrangements for handing a delayed status update are detailed herein.", "In some embodiments, a method for handling a delayed status update is presented.", "The method may include measuring, by a network-enabled sensor unit, an environmental condition.", "The method may include determining, by the network-enabled sensor unit, based on measuring the environmental condition, an environmental condition status has changed from a first state to a second state.", "The method may include establishing a network connection that permits communication with a notification service system in response to determining the environmental condition status has changed.", "The notification service system may maintain a remote environmental condition status to be synchronized with the environmental condition status of the network-enabled sensor unit.", "The method may include determining, by the network-enabled sensor unit, the environmental condition status has reverted to the first state prior to communicating the environmental condition status to the notification service system via the established network connection.", "The method may include transmitting, by the network-enabled sensor unit, a historical status array to the notification service system via the established network connection in response to determining the environmental condition status has reverted to the first state prior to communicating the environmental condition status to the notification service system.", "The historical status array may indicate one or more previous states of the environmental condition status of the network-enabled sensor unit.", "The remote environmental condition status may remain unchanged at the notification service system.", "Embodiments of such a method may include one or more of the following features: The method may include determining, by the network-enabled sensor unit, an amount of time that has elapsed between determining the environmental condition status has changed from the first state to the second state and the network connection being established.", "The method may include comparing, by the network-enabled sensor unit, the determined amount of time with a stored threshold amount of time.", "Transmitting the historical status array to the notification service system may be contingent on the determined amount of time not exceeding the stored threshold amount of time.", "The method may include parsing, by the notification service system, the transmitted historical status array to analyze the one or more previous states of the environmental condition status of the network-enabled sensor unit.", "The method may include determining, by the notification service system, based on parsing the historical status array, to transmit a user notification indicative of the environmental condition.", "The method may include accessing, by the notification service system, a database that links a user device with the network-enabled sensor unit.", "The method may include causing, by the notification service system, a notification to be transmitted to the user device indicative of the environmental condition.", "The notification may be a push notification and the user device is a cellular telephone, the push notification being transmitted to the user device without a request having been sent from the user device to the notification service system.", "The method may include broadcasting, by the network-enabled sensor unit, a message indicative of the second state via a local wireless communication protocol distinct from a protocol used for the network connection.", "The method may include receiving, by the notification service system, a suppression message from a user device associated with the network-enabled sensor unit.", "The method may include, in response to the suppression message, suppressing transmission of a notification to the user device based on parsing of the historical status array.", "The environmental condition that is measured may be an amount of smoke or an amount of carbon monoxide.", "The network-enabled sensor unit may be exclusively battery powered.", "The method may include periodically establishing, by the network-enabled sensor unit, the network connection that permits communication with the notification service system absent the environmental condition status changing.", "In some embodiments, a system for handling a delayed status update is presented.", "The system may include a network-enabled wireless unit that includes a wireless network interface, one or more processors, and a memory.", "The memory may be communicatively coupled with and readable by the one or more processors.", "The memory may have stored therein processor-readable instructions which, when executed by the one or more processors, cause the one or more processors to determine a local status has changed from a first state to a second state, wherein the local status is maintained at the network-enabled wireless unit.", "The instructions may cause the one or more processors to establish a network connection that permits communication with a notification service system in response to determining the local status has changed.", "The notification service system may maintain a remote status to be synchronized with the local status of the network-enabled wireless unit.", "The instructions may cause the one or more processors to determine the local status has changed prior to synchronization with the notification service system via the established network connection.", "The instructions may cause the one or more processors to transfer, via the wireless network interface and the established network connection, a historical status array to the notification service system in response to determining the local status has changed prior to synchronization.", "The historical status array may indicate one or more previous states of the local status of the network-enabled wireless unit.", "The remote status may remain unchanged at the notification service system.", "Embodiments of such a system may include one or more of the following features: The system may include the notification service system accessible by the network-enabled wireless unit via the network connection.", "The notification service may be configured to determine, based on parsing the historical status array, to transmit a user notification indicative of the second state.", "The notification service may be configured to access a database that links a user device with the network-enabled wireless unit.", "The notification service may be configured to transmit a notification to the user device indicative of the second state.", "The notification service may be configured to process a received suppression message from a user device associated with the network-enabled wireless unit.", "The notification service may be configured to, in response to the received suppression message, suppress transmission of a notification to the user device based on an analysis of the historical status array.", "The network-enabled wireless unit may include a local direct wireless communication interface distinct from the wireless network interface.", "The notification service may be configured to broadcast, via the local direct wireless communication interface, a message indicative of the second state.", "The system may include a mobile device.", "The mobile device may be configured to receive and process the broadcast message indicative of the second state, the broadcast message being received directly from the network-enabled wireless unit.", "The mobile device may be configured to, in response to the processed broadcast message, present an indication of the second state.", "The mobile device may be configured to, in response to the processed broadcast message, transmit a suppression message to the notification service system, wherein the suppression message instructs the notification service system to suppress notification to the user device.", "The network-enabled wireless unit may include an environmental sensor that measures an environmental condition and the local status is based on measurements made by the environmental sensor and the environmental condition is an amount of smoke or carbon monoxide.", "The network-enabled wireless unit may include a power supply, the power supply providing power to components of the network-enabled wireless unit exclusively from one or more batteries.", "The wireless device may be further configured to determine an amount of time that has elapsed between determining the local status has changed from the first state to the second state and the network connection being established.", "The wireless device may be further configured to compare the determined amount of time with a stored threshold amount of time.", "Transmitting the historical status array to the notification service system may be contingent on the determined amount of time not exceeding the stored threshold amount of time.", "In some embodiments, a non-transitory processor-readable medium is presented.", "The medium may include instructions that cause one or more processors to determine a local status has changed from a first state to a second state based on measurements from one or more environmental sensors.", "The medium may include instructions that cause one or more processors to establish a network connection that permits communication with a notification service system in response to determining the local status has changed, wherein the notification service system maintains a remote status to be synchronized with the local status.", "The medium may include instructions that cause one or more processors to determine the local status has reverted to the first state following the network connection being established but prior to synchronization with the notification service system.", "The medium may include instructions that cause one or more processors to transfer, via a wireless network interface, a historical status array to the notification service system in response to determining the local status has reverted to the first state prior to synchronization, wherein the remote status remains unchanged at the notification service system due to the local status having reverted to the first state prior to synchronization.", "In some embodiments, the medium may include instructions that cause one or more processors to determine an amount of time that has elapsed between determining the local status has changed from the first state to the second state and the network connection being established.", "The medium may include instructions that cause one or more processors to compare the determined amount of time with a stored threshold amount of time.", "Transmitting the historical status array to the notification service system may be contingent on the determined amount of time not exceeding the stored threshold amount of time.", "BRIEF DESCRIPTION OF THE DRAWINGS A further understanding of the nature and advantages of various embodiments may be realized by reference to the following figures.", "In the appended figures, similar components or features may have the same reference label.", "Further, various components of the same type may be distinguished by following the reference label by a dash and a second label that distinguishes among the similar components.", "If only the first reference label is used in the specification, the description is applicable to any one of the similar components having the same first reference label irrespective of the second reference label.", "FIG.", "1 illustrates a block diagram of a system for handling delayed status updates.", "FIG.", "2 illustrates a block diagram of an environmental monitoring system for handling delayed status updates.", "FIG.", "3A illustrates an embodiment of a historical status array that can be transmitted in the event of a delayed status update.", "FIG.", "3B illustrates an embodiment of a remote data array that can be maintained by a notification service system about a wireless sensor unit.", "FIG.", "4 illustrates an embodiment of a complex in-home wireless environment in which wireless devices can be configured for handling delayed status updates.", "FIG.", "5 illustrates an embodiment of a method for handling a delayed status update.", "FIG.", "6 illustrates another embodiment of a method for handling a delayed status update.", "FIGS.", "7A and 7B illustrates another embodiment of a method for handling a delayed status update.", "FIG.", "8 illustrates an embodiment of a method for suppressing delayed status updates in response to a direct-to-mobile notification being delivered.", "FIG.", "9 illustrates an embodiment of a push notification which can be received in response to a retroactive messaging event.", "FIG.", "10 illustrates an embodiment of a computer system that can be incorporated as part of the network-enabled devices and notification service system.", "DETAILED DESCRIPTION “Smart devices” typically refer to computerized network-enabled devices.", "Some of such devices can be installed in a home or another type of structure and can include smoke and carbon monoxide (CO) detectors.", "Smoke and CO detectors can be individual devices or incorporated as part of a single device (collectively referred to as hazard detectors).", "A smart hazard detector may have the ability to alert a user via a network connection when a hazard, such as smoke or carbon monoxide, is detected in the environment of the hazard detector.", "For instance, regardless of whether the user is at home or another remote location, a user device possessed by the user that has been associated with the hazard detector may receive a notification that the hazard has been detected.", "Ideally, when a hazard is detected by a smart hazard detector, a user device may present a notification in real time (that is, as close to immediately as possible, such as within a few seconds).", "However, such smart hazard detectors may not be continuously connected with a network that allows for such a notification to be sent immediately.", "Such hazard detectors may be “low power” devices that rely on one or more batteries for power.", "For such devices, a continuous connection to a wireless network may drain the batteries at a significant rate, rendering the ability to stay continuously connected with the network impractical.", "Further, even if the hazard detector is not a low-power device that is only intermittently connected with a wireless network, when a hazard is detected, there is no guarantee that the network itself will be immediately available.", "For example, the power may be out and/or wireless traffic or interference may prevent immediate connection with the wireless network.", "Once a hazard detector successfully establishes a network connection, status information about the hazard detector may be transmitted to a remote server system.", "This remote server system may then send one or more notifications (e.g., push notifications) to one or more user devices based on the status information (e.g., informing one or more users of a detected hazardous condition).", "However, a delay between when a smart hazard detector detects the hazardous condition and when the hazard detector is able to communicate with a network may result in a hazard event being “missed.” In such a missed situation, by the time that the hazard detector provides status information to the remote server system, the status of the hazard detector has returned to a normal or standby state.", "In such a missed situation, the remote server may receive current status information indicating that the hazard detector is in a normal or standby state (indicative of no significant amount of hazard being measured in the hazard detector's ambient environment).", "As an example of such a situation, a person burning toast, resulting in a few wisps of smoke, may briefly trigger the hazard detector to register a hazardous condition and change a state of a status of the hazard detector from standby to smoke detected or some equivalent.", "By the time the hazard detector connects with the remote server to report the state change, the smoke may have sufficiently dissipated such that the hazard detector returns to a standby state.", "While the hazard detector may have briefly sounded and/or provided a visual alert, the one or more users associated with a user account of the hazard detector may not receive a notification via their user devices because the status of the hazard detector returned to the standby state prior to the hazard detector updating its status with the remote server system.", "Such an arrangement can cause a loss of confidence in the hazard detector (and/or a user's home automation system) because the one or more users did not receive an expected notification.", "To remedy such an occurrence and possibly help prevent any loss of confidence in the hazard detector (and/or home automation system), the hazard detector and remote server system may be configured to provide notifications indicative of the hazard in certain situations even if the hazardous condition is no longer detected by the hazard detector.", "Such notifications, which refer to an event that has already concluded, can be understood as “retroactive messages.” If, by the time the hazard detector is able to effectively communicate with the remote server system via a network connection, the hazard is no longer detected, a historical status array may be provided to the remote server system instead of or in addition to the detector's current status.", "This historical status array, which can be in the form of a table, may only be provided to the server system if less than a threshold amount of time has elapsed since the detector has transitioned back to the standby state.", "The historical status array may be analyzed by the remote server system according to rules that are maintained on the server to determine if a notification should be sent to the one or more user devices and, if so, what the content of the notification should be.", "If the analysis of the array results in a determination that a notification should be sent, the one or more user devices may receive push notifications that indicate the hazard event indicated to the remote server system in the historical status array.", "While the above description is focused on smoke and/or carbon monoxide hazard detectors, it should be understood that the principles detailed throughout this document can be extended to other types of hazard detectors and, more generally, sensor units, such as humidity sensor units, temperature sensor units (e.g., thermostats), ammonia sensor units, alarm systems (e.g., home security systems), water leak sensor units, etc.", "Further, such use of a historical array for out-of-date state information can have applications in devices other than sensor units that periodically lose connectivity with a remote server system, such as mobile or non-mobile cellular devices, wireless devices, and wireless equipment.", "Additionally, while the embodiments detailed herein are focused on devices that communicate wirelessly, it should be understood that the principles detailed herein can be applied to wired network arrangements.", "FIG.", "1 illustrates a block diagram of a system 100 for handling delayed status updates.", "System 100 may include wireless device 110, notification service system 120, user device 130 (which can also be referred to as a mobile device), and network 140.Wireless device 110 may be a power-limited device: meaning a device at which power consumption is a significant concern.", "An example of a power-limited device is a battery-powered device.", "Since it may be undesirable for batteries to be changed frequently, the amount of wireless communication conducted by wireless device 110 may be limited, such as by only having wireless device 110 intermittently connected with network 140.Various examples of wireless device 110 can include: smoke detectors, carbon monoxide detectors, thermostats, and alarm systems.", "Such devices may be exclusively battery powered.", "Alternatively, or additionally, such devices may receive power from a wired power source.", "For example, a smoke and/or CO detector may use a hard-wired power source that is connected with a structure's power circuit.", "Wireless device 110 can represent a device that is only intermittently connected with network 140.This intermittent connection is represented by dotted line 111.Wireless device 110 may only connect with network 140 in certain circumstances, such as based on: 1) a state change of wireless device 110; and 2) a periodic or scheduled check-in with notification service system 120 (e.g., once every hour, two hours, eight hours, day, week, etc.).", "When wireless device 110 attempts to connect with network 140, the connection may not be immediately available.", "For instance, depending on the protocol used and the amount of wireless traffic, it could take several seconds or even minutes for wireless device 110 to connect with network 140.Further, network 140 may not be immediately available.", "The amount of time for wireless device 110 to successfully connect with network 140 may be contingent on whether a portion of network 140 is available.", "For example, a power outage could affect whether network 140 is available for a connection with wireless device 110.Network 140 can represent one or more connected networks that allow wireless device 110 and other computerized devices to communicate with each other.", "Typically, network 140 may include the Internet, and internet service provider's network, and a local wireless network.", "The wireless network may be restricted to the vicinity of wireless device 110, such as a wireless local area network (WLAN) that operates according to an IEEE 802.11 protocol.", "Such a WLAN may be hosted by a router located at the structure at which wireless device 110 is located.", "Other types of wireless communication with network 140 may also be possible, such as via wireless communication according to the IEEE 802.15.4 protocol, Bluetooth®, Wi-Fi Direct® or another wireless communication protocol.", "Network 140 is in communication with notification service system 120.Notification service system 120 may be one or more computer systems that may be geographically distributed that provide services, including notification services.", "Notification service system 120 may intermittently receive data from wireless device 110.Receipt of such data can be dependent on wireless device 110 being able to properly establish a communication connection with notification service system 120 via network 140.Therefore, if one or more components of network 140 are unavailable (e.g., router, cable modem, DSL modem, fiber optic link, Internet Service Provider (ISP) system, etc.)", "it may not be possible for notification service system 120 to receive status information from wireless device 110.When network 140 is functioning and wireless device 110 is able to communicate with network 140 (and notification service system 120 is able to communicate with network 140), notification service system 120 can receive periodic check-in messages from wireless device 110 and/or notifications of state changes at wireless device 110.Notification service system 120 may analyze state data received from wireless device 110 and determine if a notification should be transmitted.", "If notification service system 120 determines that a notification should be transmitted based on data received from wireless device 110, notification service system 120 may identify one or more user devices, such as user device 130, associated with wireless device 110.For example, based on an identifier received with data from wireless device 110, notification service system 120 may determine that user device 130 is linked with wireless device 110.A notification indicative of the information received by notification service system 120 may be provided to user device 130.The notification sent by notification service system 120 to user device 130 may be a push notification.", "Such a push notification may not require information sent by notification service system 120 to user device 130 to be in response to a request originating from the user device.", "User device 130 may be any form of computerized device which can communicate with network 140.User device 130 may use a WLAN, LAN, cellular network, and/or the Internet to communicate with notification service system 120.Examples of user device 130 can include: smartphones, cellular phones, tablet computers, laptop and desktop computers, Internet-enabled televisions, and other network-enabled computing devices.", "User device 130 may receive the push notification and present information indicative of the notification, such as via a pop-up message, a banner message, a message within an application installed on or otherwise accessible through user device 130, and/or text message.", "While FIG.", "1 illustrates a single wireless device and user device, it should be understood that notification service system 120 may manage notification for a large number of wireless devices, such as tens or hundreds of thousands of wireless devices.", "For each wireless device which communicates with notification service system 120, notification service system 120 may maintain a status array indicative of one or more states of the corresponding wireless device.", "For example, in association with an identifier of wireless device 110, the following fields may be stored by notification service system 120: an indication of a first status, an indication of a second status, a history of the first status, and a history of the second status.", "In this example, while wireless device 110 has two distinct statuses, it should be understood that in other embodiments, wireless device 110 may have a single status or more than two.", "When wireless device 110 establishes a network connection with notification service system 120 in response to a state change of a first status at wireless device 110, it may write the state of the first status to the corresponding field maintained by notification service system 120.However, if by the time wireless device 110 has successfully established a communication link with notification service system 120, the first status of wireless device 110 has reverted to a previous state (e.g., a standby state), the status written to notification service system 120 may not change (or, alternatively, wireless device 110 may not perform the write since the value stored by notification service system 120 already reflects the current status).", "For example, the first status of wireless device 110 may have two (or more) possible values, such as “standby” and “alarm.” Notification service system 120 can have one or more fields that store remote indications of these statuses.", "A transition from standby to alarm at wireless device 110 may trigger wireless device 110 to establish a communication link via network 140 with notification service system 120.By the time that wireless device 110 is able to update the first status at notification service system 120, the first status may have reverted back to standby at wireless device 110.As such, regardless of whether or not wireless device 110 writes the now-active standby status to the associated field of notification service system 120, the remote status value stored by notification service system 120 remains unchanged from its previous value (assuming that the remote status value was set to standby prior to the communication link being established).", "Since the standby value is unchanged at notification service system 120, notification service system 120 may not be triggered to take any notification action based on the stored remote status value.", "Since the first remote status was not changed by wireless device 110, it may provide a historical array indicative of previous states of the first status to notification service system 120.This historical array may include multiple previous states of the first status and associated timestamp indications.", "Notification service system 120 may then parse or otherwise analyze this array to determine if a notification should be transmitted to user device 130, and, if so, possibly determine the content of the notification.", "FIG.", "2 illustrates a block diagram of an environmental monitoring system 200 for handling delayed status updates.", "Environmental monitoring system 200 can represent a more detailed embodiment of system 100 of FIG.", "1.System 200 can include: wireless sensor unit 210, notification service system 220, network 240, router/access point (AP) 245, user device 130 and push notification service 250.It should be understood that wireless sensor unit 210 can represent an embodiment of wireless device 110, notification service system 220 can represent notification service system 120, and network 240 can represent an embodiment of network 140.Wireless sensor unit 210 may be a device that includes one or more on-board sensors, such as environmental sensors, that measures one or more ambient environmental conditions.", "For example, wireless sensor unit 210 may be a smoke detector and/or CO detector.", "In other embodiments, wireless sensor unit 210 may be an alarm system or some other type of sensor unit or wireless unit.", "Wireless sensor unit 210 may include: environmental sensor 211, status update engine 212, historical status array 213, and communication interface 214.Environmental sensor 211 may represent a sensor that outputs measurements of an ambient environmental condition, such as smoke or CO.", "Such measurements may be quantified and provided to status update engine 212.Status update engine 212 may represent a process that is executed by one or more general- or special-purpose processors or controllers.", "It should be understood that wireless sensor unit 210 is a computerized device having an embodiment of computer system 1000 integrated on-board as part of the unit.", "Status update engine 212 may monitor measurements made by environmental sensor 211 to determine a state to which a status of wireless sensor unit 210 should be set.", "The status may have two or more possible states.", "In some embodiments, the status has three or four states.", "For example, the states may be: “standby,” “heads-up,” and “alarm.” The “standby” state may be indicative of less than a first threshold amount of an environmental condition (e.g., an environmental hazard) being sensed by environmental sensor 211.The “heads-up” state may be indicative of less than a second threshold amount of the environmental condition being sensed by environmental sensor 211, but greater than the first threshold amount.", "This amount of the environmental condition can be generally understood as significant enough for it to be worthwhile to inform a user of its presence, but not significant enough to sound an alarm.", "The “alarm” state may be indicative of greater than a second threshold amount of the environmental condition being sensed by environmental sensor 211.This alarm state may cause an auditory and/or visual alarm to be output locally by wireless sensor unit 210.For example, if wireless sensor unit 210 is a combination smoke and CO detector, if a large amount of smoke is detected, the alarm state may be entered by status update engine 212 and a loud alarm may be sounded.", "Status update engine 212 may at least: 1) periodically (e.g., once per hour, day, etc.)", "send a status update to notification service system 220; and 2) send a status update to notification service system 220 when a status change occurs at wireless sensor unit 210.Status update engine 212 may maintain a local status table similar to Table 1 that indicates a smoke status, a CO status, and an indication of whether a synchronization of the status has been performed.", "TABLE 1 Smoke Status CO Status Synchronized Value Standby Alarm N Additionally, status update engine 212 may write an indication of the status change to historical status array 213.Historical status array 213 can represent multiple arrays for each status of the wireless sensor unit or can be a single array for the one or more statuses of wireless sensor unit 210.For example, referring to Table 1, a separate historical status array may be maintained for the smoke status and the CO status.", "When a status transitions from standby to a state other than standby, the historical status array may be cleared and the new status may be written to historical status array 213.Mobile device 130 may communicate with notification service system 220 via router/access point 245 and/or directly via network 240 (e.g., via a cellular network).", "Additionally, in some embodiments, communication between wireless sensor unit 210 and mobile device 130 may be performed directly.", "Therefore, if communication with router/access point 245, network 240, and/or notification service system 220 is not available, wireless sensor unit 210 may be able to communicate directly with mobile device 130.For example, direct communication 247 may be established using Bluetooth®, Bluetooth Low Energy® (BLE), WiFi Direct®, or some other protocol that allows for local device-to-device communication.", "Direct communication 247 may be performed by a wireless communication interface distinct from the wireless communication interface used to communicate with router/access point 245.In some embodiments, when a state change occurs to a status at wireless sensor unit 210, in addition to writing the state change to historical status array 213 and attempting to communicate with notification service system 220, wireless sensor unit 210 may broadcast, such as via Bluetooth, an indication of the state change.", "If within communication range of wireless sensor unit 210, mobile device 130 may receive the broadcast.", "In some embodiments, mobile device 130 may only process the broadcast if an application 131 associated with wireless sensor unit 210, is being executed.", "For example, if a user has application 131 active on mobile device 130 and wireless sensor unit 210 is within communication range for direct communication 247 and wireless sensor unit 210 changes state, an indication of the state change may be presented to the user of mobile device 130 based on the received broadcast, such as “Smoke levels are rising in the Office.” Since the direct communication may be sent as a broadcast, wireless sensor unit 210 may be unware whether or not a notification has been presented to a user via mobile device 130.Thus, to prevent a future notification from being sent to the mobile device based on the notification service system 220 parsing the historical array, mobile device 130 may transmit a message to notification service system 220 to suppress notifications for a period of time.", "For example, in response to presenting a notification in response to receiving a broadcast from wireless sensor unit 210, application 131 may cause mobile device 130 to send a message to notification service system 220 that suppresses notification from being sent to mobile device 130 (and possibly other mobile devices).", "This may involve a flag or field associated with wireless sensor unit 210 being set within sensor unit status database 224.This flag or field may be cleared by notification service system 220 after a defined period of time (e.g., five minutes) and/or may be cleared based on a subsequent message transmitted from mobile device 130.In order for notification engine 223 to transmit a notification to mobile device 130 and/or for historical array parsing engine 222 to parse a received historical status array 213, it may be required that the field or field associated with a direct notification stored by sensor unit status database 224 indicate that a notification as a result of direct communication has not been output by mobile device 130.FIG.", "3A illustrates a sample historical status array 300A that can be stored as historical status array 213 and which may be transmitted in the event of a delayed status update.", "For example, historical status array 300A may be for a smoke or CO status of wireless sensor unit 210.Historical status array 300A may be stored in the form of a table and may include historical state values for a particular status (which can be represented by a numeric value indicative of the state), an indication of whether the state has already been synchronized with notification service system 220, and a timestamp, which can be stored in the form of UTC (Coordinated Universal Time) seconds.", "Historical status array 300A may have a maximum number of stored historical entries, such as two, three, four, five, or some greater number.", "In some embodiments, the previous four entries are stored.", "In such embodiments, if more than four entries are written to historical status array 300A prior to historical status array 300A being cleared, the oldest entry may be dropped.", "As such, historical status array 300A may maintain the most recent four entries.", "Historical status array 300A is illustrated as having a state for a single status (such as smoke status or CO status).", "It should be understood that separate historical status arrays may be maintained for smoke, CO, and/or any other environmental condition that is monitored by wireless sensor unit 210, or a single historical status array 300A can be maintained that has fields for multiple statuses (or states of the multiple statuses can be combined into a single field).", "FIG.", "3B illustrates an embodiment of a remote data array 300B that can be maintained by a notification service system about a wireless sensor unit or other form of wireless unit.", "Remote data array 300B, which can be in the form of a table, can maintain information about many wireless sensor units, such as including wireless sensor unit 210.Remote data array 300B can include: a unique identifier of a wireless sensor unit field (which can be used as the database key), a state field, a synchronized field, a timestamp field, a CO status history, and a smoke status history.", "When the wireless sensor unit transmits data to the notification service system, the data transmitted may be used to update the fields associated with the identifier of the wireless sensor unit.", "The state field may be a field that is indicative of one or more states, such as states related to CO and smoke.", "(In other embodiments, separate fields may be stored by the notification service system that indicate different statuses, such as a smoke state and a CO state.)", "This state field can be understood as a remote state field, as it ideally represents the current state(s) of one or more statuses of the wireless sensor unit, but this is not always possible to the latency of the wireless sensor unit establishing a communication link with the notification service system.", "The timestamp field may indicate a (UTC) time when the last time the status field was updated.", "CO status history and smoke status history fields may store arrays of data.", "When a historical status array, such as 300A, is to be used in sending a notification to the user, the historical status array may be uploaded or otherwise transmitted to the corresponding data array field depending on the type of environmental condition.", "That is, a CO historical status array would be uploaded to the CO status history array; and a smoke historical status array would be uploaded to the smoke status history array.", "A write to either of these arrays stored by the notification service system can trigger parsing of the arrays by a process of the notification service system to determine if a notification should be sent.", "In response to a status as presented in table 1 being changed by status update engine 212 based on measurements from environmental sensor 211, communication interface 214 may be activated to establish a communication path with notification service system 220.In some embodiments, communication interface 214 communicates via a wireless communication protocol with router/access point 245.Wireless link 244 may be established by communication interface 214 to communicate with router/access point 245.Further, based on the status changing, it may be necessary for status update engine 212 to wake wireless sensor unit 210 from a sleep state.", "Such a wake sequence may take a significant amount of time, such as greater than 15 seconds (e.g., 17.5 seconds).", "Further, to establish a link with router/access point 245, it may take a substantial amount of time, such as up to a minute, or in some cases, greater than a minute.", "For wireless sensor unit 210 to successfully communicate with notification service system 220, it may also be necessary for router/access point 245 to have an active connection with network 240.Router/access point 245 may include a router, modem, and/or other equipment that allows wireless sensor unit 210 to communicate with network 240.Router/access point 245 may use communication link 246 to communicate with an ISP through which wireless sensor unit 210 can communicate with computer systems in communication with the Internet.", "The ability of wireless sensor unit 210 to communicate with notification service system 220 may be contingent on communication link 246 being available.", "As such, if communication link 246 is temporarily not available, the amount of time for wireless sensor unit 210 to provide status update information to notification service system 220 may be increased.", "This is additionally true for the communication link 248 between network 240 and notification service system 220.Notification service system 220 may include: remote status update engine 221, historical array parsing engine 222, notification engine 223, and sensor unit status database 224.It should be understood that notification service system 220 is a computerized device, such as one or more computer servers, that can include an embodiment of computer system 1000 of FIG.", "10.Notification service system 220 may store an array of data for each wireless sensor unit, including wireless sensor unit 210, which is registered with notification service system 220 in sensor unit status database 224.When remote status update engine 221 determines that a state for one or more statuses of a wireless sensor unit 210 has been changed, in response, a notification may be sent by notification engine 223 to a user device associated with the wireless device.", "However, if the state of a status is not changed by a wireless sensor unit in the wireless sensor unit's associated data array, notification engine 223 may not be triggered by remote status update engine 221 to send a notification to an associated user device.", "Status update engine 212 may first attempt to provide current status information of wireless sensor unit 210 to remote status update engine 221.If, by the time a communication link is established between communication interface 214 and notification service system 220, the current one or more statuses of wireless sensor unit 210 have reverted to standby states and/or the reversion of the status at wireless sensor unit 210 has caused the status information that was to be provided to match status information already stored by remote status update engine 221 for wireless sensor unit 210, status update engine 212 may, additionally or alternatively, provide historical status information to notification service system 220 from historical status array 213.If, by the time communication interface 214 has established a communication link with notification service system 220, the one or more statuses of wireless sensor unit 210 have reverted to a standby state, status update engine 212 may evaluate whether it is appropriate to send data from stored historical status array 213.Status update engine 212 may evaluate if less than a predefined, stored amount of time has elapsed between when the state of the wireless sensor unit reverted to standby and when the communication link was successfully established with notification service system 220.In some embodiments, the predefined amount of time is five minutes; however, it may be greater or smaller in other embodiments, such as 1, 2, 3, 4, 10, 15, or 60 minutes.", "If the predefined time period has not been exceeded, historical status array 213 may be sent to notification service system 220 for storage in association with the data stored by sensor unit status database 224 associated with wireless sensor unit 210 (such as in FIG.", "3B).", "In some embodiments, a flag may be toggled or set in the remote data array stored by sensor unit status database 224 that indicates that historical status array 213 has been provided to and stored by sensor unit status database 224.In other embodiments, based on a write of a historical status array to notification service system 220 being performed, historical array parsing engine 222 may be triggered to analyze the newly uploaded historical status array.", "Historical array parsing engine 222 may analyze the received historical status array now stored by sensor unit status database 224 to determine if: 1) a push notification should be sent to an associated user device by notification engine 223; and 2) what message the notification should include.", "Historical array parsing engine 222 may use various locally-stored rules to determine if a notification is appropriate to send based on parsing of the received historical status array.", "For example, historical array parsing engine 222 may assess whether: 1) the most recent state for a status in the historical status array is standby; and 2) the previous states of the status in the historical status array have not been synchronized (as indicated in the synchronized field of historical status array 300A).", "These two conditions can be indicative of a “completely missed” event (such as smoke or CO being detected and then dissipating) for which no notification has yet been sent to a user device.", "If historical array parsing engine 222 determines that a notification should be sent to the associated device, notification engine 223 may determine an appropriate user device to which the message should be sent by accessing sensor unit status database 224 (or some other database) which stores information that links wireless sensor units with user contact data (e.g., email addresses, application instances, phone numbers, etc.).", "Notification engine 223 may send a notification based on the analysis performed by historical array parsing engine 222.Notification engine 223 may assign an appropriate message from a database or table of messages that are correlated to various outcomes of analysis performed by historical array parsing engine 222.For example, such responses can be understood as retroactive that include messages indicative of a past condition that is no longer present: “The smoke has cleared.”; “There was smoke, but now it has cleared.”; “Smoke was briefly detected in your home.", "It cleared quickly.”; “Carbon monoxide has cleared.”; “There was carbon monoxide, but now it has cleared.”; and “Carbon Monoxide was briefly detected in your home.", "It cleared quickly.” represent a handful of examples.", "The content of the message sent would, of course, vary based on the type of environmental condition sensed.", "As an example of how such a notification may be presented to an end user, FIG.", "9 illustrates an embodiment of a push notification 900 being presented on a user device.", "Such a notification can be understood as a retroactive message since the condition the user is being notified of has already concluded.", "Depending on the type of user device, push notification may be controlled by a particular entity.", "Push notification service 250 may handle all push notifications being sent to a particular brand of device or device operating a particular operating system (e.g., Android®, iOS®).", "As such, notification engine 223 may transmit the desired push notification to push notification service 250 along with an identifier of the user device, such as user device 130, to which the notification is to be pushed.", "Push notification service 250 may be operated by a third-party operator.", "Push notification service 250 may then cause the notification to be sent to the associated user device.", "In other embodiments, notification engine 223 may be able to push notifications directly to user devices without a separate or third party push notification service being used.", "Wireless sensor units, as detailed in relation to FIG.", "2, can operate in complicated wireless environments, such as in homes or other forms of structures, that have multiple smart devices.", "FIG.", "4 illustrates an example of a smart-home environment 400 within which one or more of the devices, methods, systems, services, and/or computer program products described further herein can be applicable.", "The depicted smart-home environment 400 can include a structure 450, which can include, e.g., a house, office building, garage, or mobile home.", "It will be appreciated that devices can also be integrated into a smart-home environment 400 that does not include an entire structure 450, such as an apartment, condominium, or office space.", "Further, the smart home environment can control and/or be coupled to devices outside of the actual structure 450.Indeed, several devices in the smart home environment need not physically be within the structure 450 at all.", "For example, irrigation monitor 416 can be located outside of the structure 450.The depicted structure 450 includes a plurality of rooms 452, separated at least partly from each other via walls 454.The walls 454 can include interior walls or exterior walls.", "Each room can further include a floor 456 and a ceiling 458.Devices can be mounted on, integrated with and/or supported by a wall 454, floor 456 or ceiling 458.In some embodiments, the smart-home environment 400 of FIG.", "4 includes a plurality of devices, including intelligent, multi-sensing, network-connected devices, that can integrate seamlessly with each other and/or with a central server or a cloud-computing system to provide any of a variety of useful smart-home objectives.", "The smart-home environment 400 may include one or more intelligent, multi-sensing, network-connected thermostats 402 (hereinafter referred to as smart thermostats 402, which can function as wireless sensor unit 210), one or more intelligent, network-connected, hazard detectors 404, which can also function as wireless sensor unit 210, and one or more intelligent, multi-sensing, network-connected entryway interface devices 406 (hereinafter referred to as “smart doorbells 406”), which can function as wireless sensor unit 210 (e.g., to detect the presence of a person and/or a doorbell press).", "According to embodiments, the smart thermostat 402 detects ambient climate characteristics (e.g., temperature and/or humidity) and controls a HVAC system 403, accordingly.", "The hazard detector 404 may detect the presence of a hazardous substance or a substance indicative of a hazardous substance (e.g., smoke, fire, or carbon monoxide).", "Entryway interface device 406 may detect a person's approach to, or departure from, a location (e.g., an outer door), control doorbell functionality, announce a person's approach or departure via audio or visual means, or control settings on a security system (e.g., to activate or deactivate the security system when occupants go and come).", "In some embodiments, the smart-home environment 400 of FIG.", "4 further includes one or more intelligent, multi-sensing, network-connected wall switches 408 (hereinafter referred to as “smart wall switches 408”), along with one or more intelligent, multi-sensing, network-connected wall plug interfaces 410 (hereinafter referred to as “smart wall plugs 410”).", "The smart wall switches 408 may detect ambient lighting conditions, detect room-occupancy states, and control a power and/or dim state of one or more lights.", "In some instances, smart wall switches 408 may also control a power state or speed of a fan, such as a ceiling fan.", "The smart wall plugs 410 may detect occupancy of a room or enclosure and control the supply of power to one or more wall plugs (e.g., such that power is not supplied to the plug if nobody is at home).", "Again, such devices may be used as wireless sensor unit 210.Still further, in some embodiments, the smart-home environment 400 of FIG.", "4 includes a plurality of intelligent, multi-sensing, network-connected appliances 412 (hereinafter referred to as “smart appliances 412”), such as refrigerators, stoves and/or ovens, televisions, washers, dryers, lights, stereos, intercom systems, garage-door openers, floor fans, ceiling fans, wall air conditioners, pool heaters, irrigation systems, security systems, and so forth.", "Such devices may be used as wireless device 110 or wireless sensor unit 210, which may report status information other than environmental conditions, such as device statuses.", "According to embodiments, the smart thermostats 402, the hazard detectors 404, the entryway interface devices 406, the smart wall switches 408, the smart wall plugs 410, and other devices of the smart-home environment 400 are modular and can be incorporated into older and new houses.", "For example, the devices are designed around a modular platform consisting of two basic components: a head unit and a back plate, which is also referred to as a docking station.", "Multiple configurations of the docking station are provided so as to be compatible with any home, such as older and newer homes.", "However, all of the docking stations include a standard head-connection arrangement, such that any head unit can be removably attached to any docking station.", "Thus, in some embodiments, the docking stations are interfaces that serve as physical connections to the structure and the voltage wiring of the homes, and the interchangeable head units contain all of the sensors, processors, user interfaces, the batteries, and other functional components of the devices.", "The smart-home environment 400 may also include communication with devices outside of the physical home, but within a proximate geographical range of the home.", "For example, the smart-home environment 400 may include an irrigation monitor 416 that communicates information regarding irrigation systems within the smart-home environment 400 and/or receives control information for controlling such irrigation systems.", "Again, such a component may function as wireless sensor unit 210 of FIG.", "2.By virtue of network connectivity, one or more of the smart-home devices of FIG.", "4 can further allow a user (such as users 497 and 498) to interact with the device even if the users are not proximate to the device and receive notification messages as detailed in relation to FIG.", "2.For example, a user can communicate with a device using a computer (e.g., a desktop computer, laptop computer, or tablet) or other portable electronic device (e.g., a smartphone) 466.A webpage or app can be configured to receive communications from the user and control the device based on the communications and/or to present information about the device's operation to the user.", "For example, the user can view a current setpoint temperature for a device and adjust it, using a computer.", "The user can be in the structure during this remote communication (such as user 497) or outside the structure (such as user 498).", "As discussed, users can control and interact with the smart thermostat, hazard detectors 404, and other smart devices in the smart-home environment 400 using a network-connected computer or portable electronic device 466.In some examples, some or all of the occupants (e.g., individuals who live in the home) can register their device 466 with the smart-home environment 400.Such registration can be made at cloud-computing system 464, which can include notification service system 220 of FIG.", "2, to authenticate the occupant and/or the device as being associated with the home and to give permission to the occupant to use the device to control the smart devices in the home.", "An occupant can use his registered device 466 to remotely control the smart devices of the home, such as when the occupant is at work or on vacation and receive notifications (e.g., push notifications).", "The occupant may also use his registered device to control the smart devices when the occupant is actually located inside the home, such as when the occupant is sitting on a couch inside the home.", "It should be appreciated that, instead of, or in addition to, registering devices 466, the smart-home environment 400 makes inferences about which individuals live in the home and are therefore occupants and which devices 466 are associated with those individuals.", "As such, the smart-home environment “learns” who is an occupant and permits the devices 466 associated with those individuals to control the smart devices of the home.", "According to embodiments, all or some of the smart devices can serve as wireless or wired repeaters.", "For example, a first one of the smart devices can communicate with a second one of the smart devices via a wireless router 460.The smart devices can further communicate with each other via a connection to a network, such as the Internet 499.Through the Internet 499, the smart devices can communicate with a cloud-computing system 464, which can include one or more centralized or distributed server systems.", "According to embodiments, the smart devices combine to create a mesh network of spokesman and low-power nodes in the smart-home environment 400, where some of the smart devices are “spokesman” nodes and others are “low-powered” nodes.", "The establishment of such mesh networks may increase an amount of time which takes a unit, such as wireless sensor unit 210 of FIG.", "2, to be able to communicate with notification service system 220, due to the extra devices involved.", "Some of the smart devices in the smart-home environment 400 are battery powered, while others have a regular and reliable power source, such as by connecting to wiring (e.g., to 110 V line voltage wires) behind the walls 454 of the smart-home environment.", "Devices that are battery powered are referred to as “low-power” nodes.", "These nodes tend to be smaller than spokesman nodes and can only communicate using wireless protocols that require very little power, such as Zigbee, 6LoWPAN, etc.", "An example of a low-power node is a smart nightlight 470.In addition to housing a light source, the smart nightlight 470 houses an occupancy sensor, such as an ultrasonic or passive IR sensor, and an ambient light sensor, such as a photodiode, photo resistor, phototransistor, or a single-pixel sensor that measures light in the room.", "Smart nightlight 470 can function as wireless sensor unit 210.In some embodiments, the smart nightlight 470 is configured to activate the light source when its ambient light sensor detects that the room is dark and when its occupancy sensor detects that someone is in the room.", "In other embodiments, the smart nightlight 470 is simply configured to activate the light source when its ambient light sensor detects that the room is dark.", "Further, according to embodiments, the smart nightlight 470 includes a low-power wireless communication chip (e.g., ZigBee chip) that regularly sends out messages regarding the occupancy of the room and the amount of light in the room, including instantaneous messages coincident with the occupancy sensor detecting the presence of a person in the room.", "As mentioned above, these messages may be sent wirelessly, using the mesh network, from node to node (i.e., smart device to smart device) within the smart-home environment 400 as well as over the Internet 499 to cloud-computing system 464.Other examples of low-powered nodes include battery-operated versions of the hazard detectors 404.These hazard detectors 404 are often located in an area without access to constant and reliable (e.g., structural) power and, as discussed in detail below, may include any number and type of sensors, such as smoke/fire/heat sensors, carbon monoxide/dioxide sensors, occupancy/motion sensors, ambient light sensors, flame detectors, air quality sensors (e.g., for VOCs, particulate matter (e.g., PM 2.5), allergens, and other unhealthy contaminants such as NOx), temperature sensors, humidity sensors, and the like.", "Furthermore, hazard detectors 404 can send messages that correspond to each of the respective sensors to the other devices and cloud-computing system 464, such as by using the mesh network as described above.", "Various methods may be performed using the systems and environments detailed in relation to FIGS.", "1, 2, and 4.FIG.", "5 illustrates an embodiment of a method 500 for handling a delayed status update.", "Each step of method 500 may be performed by an embodiment of a wireless device (e.g., wireless device 110 of FIG.", "1 or wireless sensor unit 210 of FIG.", "2).", "At block 510, the wireless device may determine that a status has changed from the first state to a second state.", "This state change from the first state to the second state may be triggered based on one or more measurements that are taken by one or more sensors that are part of the wireless device.", "In some embodiments, the status is changed based on smoke, carbon monoxide, and/or occupancy measurements.", "Alternatively, in some embodiments, the status may change from the first state to the second state based on a condition occurring other than one or more measurements being performed using a sensor.", "At block 520, in response to determining the status has changed from the first state to the second state at block 510, a network connection may be established with a remote server system.", "Referring to FIG.", "1, the network connection may be established by wireless device 110 through network 140 with notification service system 120.Referring to FIG.", "2, wireless sensor unit 210 may establish a communication link with notification service system 220 through router/access point 245 and network 240.Establishment of block 520 of the network connection may take a substantial amount of time.", "For example, it may take tens of seconds for the wireless device or wireless sensor unit itself to wake up from a low-power mode.", "Once awake, the wireless device or wireless sensor unit may take a significant amount of time to connect with a local wireless network, such as router/access point 245.For example, it may be possible that up to a minute or longer may elapse for wireless sensor unit 210 to successfully establish a wireless communication link with router/access point 245.Additional time may be required still for a successful communication link to be established between wireless sensor unit 210 and a cloud-based computing system, such as notification service system 220, that is accessible via the Internet.", "At block 530, in response to the network connection having been successfully established and the wireless device or wireless sensor unit being able to successfully communicate with the remote notification service system, the wireless device may determine if the status has reverted to the first state.", "That is, since a significant amount of time may have elapsed since block 510 was performed, it may be possible that the second state has already reverted to the first state.", "This first state may be a “standby” state.", "This standby state may be indicative of normal operating conditions and may not be informative, in and of itself, for an indication of such to be provided to a user.", "For example, the standby state may indicate that smoke and/or carbon monoxide is not being detected by the wireless device.", "Alternatively, rather than reverting to the first state, at block 540 the wireless device may determine that it has changed to a third state.", "While block 530 may be contingent on the network connection being established in some embodiments, in other embodiments the determination of block 530 may be performed following some other criteria.", "As an example of such a criteria, a fixed, predefined period of time may elapse as block 520 before block 530 is performed.", "As another example, user input or data from a computerized device may be required to be received at block 520 prior to block 530 being performed.", "As another example, a power source may be required to charge or an alarm sound at block 520 prior to block 530 being performed.", "Other criteria are also possible.", "At block 540, in response to determining that the status has reverted to the first state (or changed to a third state) at block 530 prior to the second state having been synchronized with the remote server system, a historical status array, such as the historical status array detailed in relation to FIG.", "3, may be transferred to the remote server system via the network connection.", "Accordingly, at block 540, since the current state of the wireless device has returned to standby and may match a stored remote status maintained by the remote server system, the historical status array is transmitted to the remote server system.", "Such a historical status array may only be transmitted in response to the state of the status having reverted to the first state.", "FIG.", "6 illustrates an embodiment of a method 600 for handling a delayed status update.", "Blocks of method 600 may be performed by an embodiment of wireless device (e.g., wireless device 110 of FIG.", "1 or wireless sensor unit 210 of FIG.", "2) or notification service system (e.g., notification service system 120 and 220 of FIGS.", "1 and 2, respectively).", "Method 600 can represent a more detailed embodiment of method 500 of FIG.", "5.At block 610, measurements of one or more environmental conditions may be performed using one or more environmental sensors of the wireless device or wireless sensor unit.", "In some embodiments, the environmental conditions measured include smoke and CO. At block 620, the wireless device may determine that a status has changed from a first state (e.g., a standby state) to a second state (e.g., heads-up, warning, or alarm).", "This state change from the first state to the second state may be triggered based on one or more measurements that are taken by one or more sensors that are part of the wireless device exceeding a defined threshold and, possibly, exceeding the threshold for at least a period of time.", "In some embodiments, the status is changed based on smoke, carbon monoxide, and/or occupancy measurements.", "Alternatively, in some embodiments, the status may change from the first state to the second state based on a condition occurring other than one or more measurements being performed using a sensor.", "At block 630, in response to determining the status has changed from the first state to the second state at block 620, a network connection may be established with the notification service system.", "Referring to FIG.", "2, wireless sensor unit 210 may establish a communication link with notification service system 220 through router/access point 245 and network 240 (which includes, at least, the Internet).", "Establishment at block 630 of the network connection may take a substantial amount of time as detailed in relation to block 520.At block 640, after the network connection has been established with the notification service system at block 630, the wireless sensor unit may determine whether the environmental condition status determined to have changed has reverted to the first state.", "As such, the determination made at block 640 is indicative of the environmental condition status having reverted to the first state prior to the wireless device being able to update a remote status stored by the notification service system.", "Between block 620 and block 640, zero or more than one state change may have occurred.", "Common state change sequences can include: standby to heads-up (or warning) and back to standby; standby to heads-up; standby to alarm; and stand-by to heads-up to alarm and back to standby.", "It should be understood that the names of such states may vary by embodiment and that “stand-by,” “heads-up,” and “alarm” are merely examples.", "Alternatively, rather than determining that the environmental condition status has reverted to the first state, at block 640 the wireless sensor unit may determine that the environmental condition status has changed to a third status.", "As detailed in relation to block 530, it may also be possible for performance of block 640 to be dependent on other criteria occurring.", "If, at block 640, it is determined that the environmental condition status has reverted to the first state of standby (or, possibly, changed to a third state), method 600 may proceed to block 650.At block 650, in response to determining that the status has reverted to the first status at block 640 (or, possibly, changed to a third state) prior to the second state having been synchronized with the remote server system, a historical status array, such as the historical status array detailed in relation to FIG.", "3A, may be transferred to the notification service system via the network connection.", "At block 660, the historical status array may be analyzed by the notification service system.", "The notification service system may be triggered to analyze the historical status array based on: the historical status array having been written to the notification service system or a flag or toggle bit having been set by the wireless sensor unit at the notification service system to inform the notification service system that the historical status array has been uploaded and is up-to-date.", "That is, the notification service system may store a historical status array for each wireless device for which it provides notifications, and may require that an indication be provided when such an associated historical status array should be parsed or otherwise analyzed.", "The analysis at block 660 may determine: whether the most recent status set at the wireless sensor unit, based on a timestamp, is a standby state, and if one or more previous states are listed in the array that have not previously been synchronized with the notification service system.", "As illustrated in FIG.", "6, the historical status array is not transferred to the notification service system unless the environmental condition status has reverted to the first state or, possibly, transitioned to some other third state.", "In some embodiments, the historical status array may be transmitted to the notification service system regardless of whether the status has reverted or changed.", "Rather, based on the notification service system's analysis of the historical array at block 660, a determination may be made by the historical status array that a retroactive notification is or is not necessary based on the content of the historical status array.", "For example, a rule may be enforced by the notification service system that if a notification is to be sent that indicates a the status being set to a third state, a retroactive notification about an earlier reversion to the first state is not necessary.", "At block 670, a notification may be transmitted to one or more user devices associated with the wireless sensor unit.", "The notification that is transmitted may be based on the analysis of the historical status array performed at block 660.The notification may also be indicative of the type of environmental condition that triggered the notification, such as smoke or CO.", "The user devices to which the notification is transmitted may be based upon a database entry that indicates user devices associated with the wireless sensor device from which the historical status array was received.", "If, at block 680, it is determined that the environmental condition status has not reverted to the first state of standby, method 600 may proceed to block 680.At block 680, state data indicative of the current status of the wireless sensor unit may be transferred via the network connection to the notification service system.", "Block 680 may explicitly exclude transmission of the historical status array from being transmitted to the notification service system.", "That is, if the “no” path is followed from block 640, the historical status array may not be transmitted from the wireless sensor device to the notification service system.", "FIGS.", "7A and 7B illustrates an embodiment of a method 700 for handling a delayed status update.", "Blocks of method 700 may be performed by an embodiment of wireless device (e.g., wireless device 110 of FIG.", "1 or wireless sensor unit 210 of FIG.", "2) or notification service system (e.g., notification service system 120 and 220 of FIGS.", "1 and 2, respectively).", "Method 700 can represent a more detailed embodiment of method 600 of FIG.", "6.At block 705, measurements of one or more environmental conditions may be performed using one or more environmental sensors of the wireless sensor unit.", "In some embodiments, the environmental conditions measured include smoke and/or CO. At block 710, the wireless sensor unit may determine that a status has changed from a first state (e.g., a standby state) to a second state (e.g., heads-up, warning, or alarm).", "This state change from the first state to the second state may be triggered based on one or more measurements that are taken by one or more sensors that are part of the wireless device exceeding a defined threshold and, possibly, exceeding the threshold for at least a period of time.", "In some embodiments, the status is changed based on smoke, carbon monoxide, and/or occupancy measurements.", "Alternatively, in some embodiments, the status may change from the first state to the second state based on a condition occurring other than one or more measurements being performed using a sensor.", "In response to determining that the environmental condition has changed from the first state to a second state, a historical status array stored by the wireless sensor unit may first be cleared; then an entry may be written to the historical status array at block 715 indicative of the state change of the status, a timestamp at which the state change occurred, and an indication of whether the state has been synchronized to the notification service system.", "The historical status array may resemble the table of FIG.", "3A.", "Any further changes that occur to the state of the status may be written to the historical status array as additional entries.", "The array, which may be in the form of a table, may store a maximum number of entries, such as four.", "At block 720, in response to determining the status has changed from the first state to the second state at block 710, a network connection may be established with the notification service system.", "Referring to FIG.", "2, wireless sensor unit 210 may establish a communication link with notification service system 220 through router/access point 245 and network 240 (which includes, at least, the Internet).", "Establishment at block 720 of the network connection may take a substantial amount of time as detailed in relation to block 520.At block 725, after the network connection has been established with the notification service system at block 720, the wireless sensor unit may determine whether the environmental condition status determined to have changed has reverted to the first state.", "As such, the determination made at block 725 is indicative of the environmental condition status having reverted to the first state prior to the wireless sensor unit being able to update a remote status stored by the notification service system.", "This condition may be determined at the wireless sensor unit by the historical status array having entries that precede a transition back to the first state that have yet to be synchronized with the notification service system.", "Between block 710 and block 725, zero or more than one state change (in addition to the state change of block 710) may have occurred.", "Alternatively, rather than determining that the environmental condition status has reverted to the first state, at block 725 the wireless sensor unit may determine that the environmental condition status has changed to a third status.", "Method 700 may proceed to block 730 if the wireless sensor unit determines that the environmental condition status has reverted to the first state (or, possibly, transitioned to a third state) prior to being able to communicate with the notification services system and provide a current status that is other than the first state (e.g., standby).", "At block 730, a comparison between an amount of time that has elapsed since the wireless sensor unit's status transitioned back to standby (or another first or third state) and a predefined threshold time period is performed.", "The predefined threshold time period may be stored locally by the wireless sensor device or may be retrieved from a field stored by the notification service system.", "The predefined threshold time period may vary based on the type of status.", "For example, different time periods may be set, either at the wireless sensor unit or at the notification service system, for smoke, CO, and/or another environmental condition that is monitored by the wireless sensor unit.", "If, at block 730, the comparison indicates that the elapsed amount of time that has elapsed since the reversion to the first state is greater than the predefined threshold time duration (the elapsed time exceeds the threshold), method 700 may revert to block 705.As such, since the time period was exceeded, no notification is sent to the user, and the wireless sensor unit continues to monitor the one or more environmental conditions.", "As such, a user may never be made aware that the wireless sensor unit changed from the first state to another state unless the user was in the vicinity of the wireless sensor unit during the transition and a visual and/or auditory indication was output by the wireless sensor unit.", "It should be understood that throughout method 700, the wireless sensor unit can continue to monitor the one or more environmental conditions regardless of the interactions with the notification service system, as one of the primary functions of the wireless sensor unit may be to output a local visual and/or auditory alarm if smoke, CO, and/or some other environmental condition reaches a dangerous level.", "If, at block 730, the comparison indicates that the elapsed amount of time that has elapsed since the reversion to the first state is less than the predefined threshold time duration (the elapsed time is below the threshold), method 700 may continue to block 740 on FIG.", "7B.", "At block 740, the historical status array, which would contain at least two entries (a transition away from the first state and a transition back to the first state), is transferred to the notification service system via the network connection.", "Additional transitions may also be present, such as if the sensor unit transitioned from the first to a second state, the second to a third state, then the third to the first state.", "The notification service system may store this data in relation to an array of remotely stored data for the wireless sensor unit.", "In addition, at block 740, the wireless sensor unit may provide an indication to the notification service system that the historical status array has been provided; for example, in the array of remotely stored data, the wireless sensor unit may toggle a bit or set a flag that corresponds to the historical status array.", "Alternatively, the notification service system may be able to detect the historical status array based on the wireless sensor unit performing a write function to the variable that stores the historical status array at the notification service system.", "At block 745, the historical status array may be analyzed by the notification service system.", "The notification service system may be triggered to analyze the historical status array based on: the historical status array having been transferred to the notification service system or a flag or toggle bit having been set by the wireless sensor unit at the notification service system to inform the notification service system that the historical status array has been uploaded and is up-to-date.", "That is, the notification service system may store a historical status array for each wireless device for which it provides notifications, and may require that an indication be provided when such an associated historical status array should be parsed or otherwise analyzed.", "The analysis at block 745 may determine, at least: 1) whether the most recent status set at the wireless sensor unit, based on a timestamp, is a standby state, and; 2) if one or more previous states are listed in the array that have not previously been synchronized with the notification service system.", "Based on the analysis of block 745, at block 750 a determination may be made as to whether a notification should be transmitted to a user via a user device that is indicative of the environmental condition that led to the transitions away from (and, possibly, reverting to) the first state.", "If, based on the analysis of claim block 750, the determination is no, no further action by the notification service system may be taken.", "If, based on the analysis of claim block 750, the determination is that yes, a notification should be transmitted, method 700 may proceed to block 755.At block 755, a database may be accessed to determine one or more users and/or user devices that should receive the notification.", "The wireless sensor unit may have provided an identifier that is unique from identifiers of other wireless sensor units, thus allowing the notification service system to determine the particular wireless sensor unit from which data was received.", "Such an identifier may have been provided to the notification service system at block 740.Using this identifier, the notification service system may look up an address, email address, or other identifier that can be used as an address to which the notification is to be sent.", "At block 760, the notification may be transmitted to one or more user devices associated with the wireless sensor unit.", "The content of the notification that is transmitted may be based on the analysis of the historical status array performed at block 745.The notification may also be indicative of the type of environmental condition that triggered the notification, such as smoke or CO.", "In some embodiments, the notification is sent to one or more user devices based on the database look-up of block 755 associated with the user as a push notification.", "This push notification may cause a message to be presented as a pop-up or banner on the user device.", "If, at block 725 of FIG.", "7A, it is determined that the environmental condition status has not reverted to the first state of standby, method 700 may proceed to block 765 on FIG.", "7B.", "At block 765, state data indicative of the current status of the wireless sensor unit may be transferred via the network connection to the notification service system.", "Block 765 can be in lieu of transmission of the historical status array from being transmitted to the notification service system.", "That is, if the “no” path is followed from block 725, the historical status array may not be transmitted from the wireless sensor device to the notification service system and may be eventually deleted or otherwise discarded by the wireless sensor unit such as when the wireless sensor unit transitions from the first state to another state at some time in the future.", "Following block 725, method 700 may proceed to block 755 and block 760, at which a notification indicative of the current state of the wireless sensor unit may be sent to one or more user devices associated with the wireless sensor unit.", "Since the notification is indicative of a current status and not a retroactive status, the notification can make clear that the state of the wireless sensor unit is current, such as by a message stating: “Smoke is present in the kitchen.” or “A carbon monoxide alarm is present in the basement.” FIG.", "8 illustrates an embodiment of a method 800 for suppressing delayed status updates in response to a direct-to-mobile notification being delivered by the wireless sensor unit.", "Method 800 may be performed using system 200 of FIG.", "2.Method 800 may be performed in conjunction with methods 500, 600, and 700.Therefore, blocks of method 800 may be performed interspersed with blocks or method 500,600, and 700.As previously detailed, at block 810, measurements of one or more environmental conditions may be performed using one or more environmental sensors of the wireless sensor unit.", "In some embodiments, the environmental conditions measured include smoke and CO. At block 820, the wireless sensor unit may determine that a status has changed from a first state (e.g., a standby state) to a second state (e.g., heads-up, warning, or alarm) based on the measurements of block 805.This state change from the first state to the second state may be triggered based on one or more measurements that are taken by one or more sensors that are part of the wireless device exceeding a defined threshold and, possibly, exceeding the threshold for at least a period of time.", "In some embodiments, the status is changed based on smoke, carbon monoxide, and/or occupancy measurements.", "Alternatively, in some embodiments, the status may change from the first state to the second state based on a condition occurring other than one or more measurements being performed using a sensor.", "In response to block 810, the wireless sensor unit may broadcast or otherwise transmit a message indicative of the second state.", "If broadcast, the wireless sensor unit may not be able to determine whether or not the broadcast was received a mobile device of the user and, as such, may be unable to assess whether a notification to the user via the mobile should be routed through a notification service system.", "In some embodiments, Bluetooth® or Bluetooth Low Energy® (BLE) is used to broadcast the state of the wireless sensor unit.", "At block 820, a mobile device of the user may receive the broadcast.", "The mobile device may only analyze or otherwise process the broadcast of block 815 if the mobile device is executing an application that is configured to monitor for such wireless broadcasts.", "In other embodiments, the mobile device may be configured to monitor for such broadcasts even if an application associated with the wireless sensor unit is not being executed by the mobile device.", "At block 825, if the application is being executed and the broadcast is successfully received and processed, a notification indicative of the state change from block 810 may be presented or otherwise output by the mobile device.", "The application or mobile device may store an indication that the notification has been output by the mobile device and/or that a user has acknowledged the notification based on dismissing or otherwise clearing the notification.", "At block 830, in response to the notification being analyzed at block 820, the notification being output at block 825, and/or the notification being dismissed or otherwise cleared by a user at the mobile device, the mobile device may transmit a message to the notification service system that suppresses the notification service system from transmitting notifications to the mobile device, such as for a period of time.", "The mobile device may use any available communication path to communicate with the notification service system, such as via a local router/access point or a cellular network.", "In response to receiving the suppression message at block 830, the notification service system may store an indication of the suppression message in conjunction with a database entry corresponding to the wireless sensor unit at block 835.The presence of an active suppression for the wireless sensor unit may prevent the notification service system from sending a notification based on an analysis of the historical status array.", "Referring to block 750 of FIG.", "7B, if a flag or field for a received suppression message associated with the historical status array is active, the determination of block 750 may be that no notification should be sent, regardless of the content of the historical status array.", "In other embodiments, referring to block 745, if a flag or field for a received suppression message associated with the historical status array is active, the historical status array may not be analyzed and method 700 may proceed to the “no” determination associated with block 750.As previously noted, method 800 may also be performed in conjunction with methods 500 and 600.After a period of time the mobile device may transmit a subsequent message to the notification service system that enables delayed notifications or, the flag or field set at the notification service system may time out and be reset by the notification service system (without a subsequent message from the mobile device) after a defined period of time.", "FIG.", "10 illustrates an embodiment of a computer system 1000 that can be incorporated as part of the wireless devices, wireless sensor units, user devices, notification service systems, and push notification services detailed in relation to FIGS.", "1-7B.", "FIG.", "10 provides a schematic illustration of one embodiment of a computer system 1000 that can perform various steps of the methods provided by various embodiments.", "It should be noted that FIG.", "10 is meant only to provide a generalized illustration of various components, any or all of which may be utilized as appropriate.", "FIG.", "10, therefore, broadly illustrates how individual system elements may be implemented in a relatively separated or relatively more integrated manner.", "The computer system 1000 is shown comprising hardware elements that can be electrically coupled via a bus 1005 (or may otherwise be in communication).", "The hardware elements may include one or more processors 1010, including without limitation one or more general-purpose processors and/or one or more special-purpose processors (such as digital signal processing chips, graphics acceleration processors, video decoders, and/or the like); one or more input devices 1015, which can include without limitation a mouse, a touchscreen, keyboard, remote control, and/or the like; and one or more output devices 1020, which can include without limitation a display device, a printer, etc.", "The computer system 1000 may further include (and/or be in communication with) one or more non-transitory storage devices 1025, which can comprise, without limitation, local and/or network accessible storage, and/or can include, without limitation, a disk drive, a drive array, an optical storage device, a solid-state storage device, such as a solid state drive (“SSD”), random access memory (“RAM”), and/or a read-only memory (“ROM”), which can be programmable, flash-updateable and/or the like.", "Such storage devices may be configured to implement any appropriate data stores, including without limitation, various file systems, database structures, and/or the like.", "The computer system 1000 might also include a communications subsystem 1030, which can include without limitation a modem, a network card (wireless or wired), an infrared communication device, a wireless communication device, and/or a chipset (such as a Bluetooth™ device, BLE, an 802.11 device, an 802.15.4 device, a WiFi device, a WiMax device, cellular communication device, etc.", "), and/or the like.", "The communications subsystem 1030 may permit data to be exchanged with a network (such as the network described below, to name one example), other computer systems, and/or any other devices described herein.", "In many embodiments, the computer system 1000 will further comprise a working memory 1035, which can include a RAM or ROM device, as described above.", "The computer system 1000 also can comprise software elements, shown as being currently located within the working memory 1035, including an operating system 1040, device drivers, executable libraries, and/or other code, such as one or more application programs 1045, which may comprise computer programs provided by various embodiments, and/or may be designed to implement methods, and/or configure systems, provided by other embodiments, as described herein.", "Merely by way of example, one or more procedures described with respect to the method(s) discussed above might be implemented as code and/or instructions executable by a computer (and/or a processor within a computer); in an aspect, then, such code and/or instructions can be used to configure and/or adapt a general purpose computer (or other device) to perform one or more operations in accordance with the described methods.", "A set of these instructions and/or code might be stored on a non-transitory computer-readable storage medium, such as the non-transitory storage device(s) 1025 described above.", "In some cases, the storage medium might be incorporated within a computer system, such as computer system 1000.In other embodiments, the storage medium might be separate from a computer system (e.g., a removable medium, such as a compact disc), and/or provided in an installation package, such that the storage medium can be used to program, configure, and/or adapt a general purpose computer with the instructions/code stored thereon.", "These instructions might take the form of executable code, which is executable by the computer system 1000 and/or might take the form of source and/or installable code, which, upon compilation and/or installation on the computer system 1000 (e.g., using any of a variety of generally available compilers, installation programs, compression/decompression utilities, etc.", "), then takes the form of executable code.", "It will be apparent to those skilled in the art that substantial variations may be made in accordance with specific requirements.", "For example, customized hardware might also be used, and/or particular elements might be implemented in hardware, software (including portable software, such as applets, etc.", "), or both.", "Further, connection to other computing devices such as network input/output devices may be employed.", "As mentioned above, in one aspect, some embodiments may employ a computer system (such as the computer system 1000) to perform methods in accordance with various embodiments.", "According to a set of embodiments, some or all of the procedures of such methods are performed by the computer system 1000 in response to processor 1010 executing one or more sequences of one or more instructions (which might be incorporated into the operating system 1040 and/or other code, such as an application program 1045) contained in the working memory 1035.Such instructions may be read into the working memory 1035 from another computer-readable medium, such as one or more of the non-transitory storage device(s) 1025.Merely by way of example, execution of the sequences of instructions contained in the working memory 1035 might cause the processor(s) 1010 to perform one or more procedures of the methods described herein.", "The terms “machine-readable medium,” “computer-readable storage medium” and “computer-readable medium,” as used herein, refer to any medium that participates in providing data that causes a machine to operate in a specific fashion.", "These mediums may be non-transitory.", "In an embodiment implemented using the computer system 1000, various computer-readable media might be involved in providing instructions/code to processor(s) 1010 for execution and/or might be used to store and/or carry such instructions/code.", "In many implementations, a computer-readable medium is a physical and/or tangible storage medium.", "Such a medium may take the form of a non-volatile media or volatile media.", "Non-volatile media include, for example, optical and/or magnetic disks, such as the non-transitory storage device(s) 1025.Volatile media include, without limitation, dynamic memory, such as the working memory 1035.Common forms of physical and/or tangible computer-readable media include, for example, a floppy disk, a flexible disk, hard disk, magnetic tape, or any other magnetic medium, a CD-ROM, any other optical medium, any other physical medium with patterns of marks, a RAM, a PROM, EPROM, a FLASH-EPROM, any other memory chip or cartridge, or any other medium from which a computer can read instructions and/or code.", "Various forms of computer-readable media may be involved in carrying one or more sequences of one or more instructions to the processor(s) 1010 for execution.", "Merely by way of example, the instructions may initially be carried on a magnetic disk and/or optical disc of a remote computer.", "A remote computer might load the instructions into its dynamic memory and send the instructions as signals over a transmission medium to be received and/or executed by the computer system 1000.The communications subsystem 1030 (and/or components thereof) generally will receive signals, and the bus 1005 then might carry the signals (and/or the data, instructions, etc.", "carried by the signals) to the working memory 1035, from which the processor(s) 1010 retrieves and executes the instructions.", "The instructions received by the working memory 1035 may optionally be stored on a non-transitory storage device 1025 either before or after execution by the processor(s) 1010.It should further be understood that the components of computer system 1000 can be distributed across a network.", "For example, some processing may be performed in one location using a first processor while other processing may be performed by another processor remote from the first processor.", "Other components of computer system 1000 may be similarly distributed.", "As such, computer system 1000 may be interpreted as a distributed computing system that performs processing in multiple locations.", "In some instances, computer system 1000 may be interpreted as a single computing device, such as a distinct laptop, desktop computer, or the like, depending on the context.", "The methods, systems, and devices discussed above are examples.", "Various configurations may omit, substitute, or add various procedures or components as appropriate.", "For instance, in alternative configurations, the methods may be performed in an order different from that described, and/or various stages may be added, omitted, and/or combined.", "Also, features described with respect to certain configurations may be combined in various other configurations.", "Different aspects and elements of the configurations may be combined in a similar manner.", "Also, technology evolves and, thus, many of the elements are examples and do not limit the scope of the disclosure or claims.", "Specific details are given in the description to provide a thorough understanding of example configurations (including implementations).", "However, configurations may be practiced without these specific details.", "For example, well-known circuits, processes, algorithms, structures, and techniques have been shown without unnecessary detail in order to avoid obscuring the configurations.", "This description provides example configurations only, and does not limit the scope, applicability, or configurations of the claims.", "Rather, the preceding description of the configurations will provide those skilled in the art with an enabling description for implementing described techniques.", "Various changes may be made in the function and arrangement of elements without departing from the spirit or scope of the disclosure.", "Also, configurations may be described as a process which is depicted as a flow diagram or block diagram.", "Although each may describe the operations as a sequential process, many of the operations can be performed in parallel or concurrently.", "In addition, the order of the operations may be rearranged.", "A process may have additional steps not included in the figure.", "Furthermore, examples of the methods may be implemented by hardware, software, firmware, middleware, microcode, hardware description languages, or any combination thereof.", "When implemented in software, firmware, middleware, or microcode, the program code or code segments to perform the necessary tasks may be stored in a non-transitory computer-readable medium such as a storage medium.", "Processors may perform the described tasks.", "Having described several example configurations, various modifications, alternative constructions, and equivalents may be used without departing from the spirit of the disclosure.", "For example, the above elements may be components of a larger system, wherein other rules may take precedence over or otherwise modify the application of the embodiments.", "Also, a number of steps may be undertaken before, during, or after the above elements are considered." ] ]
Patent_15874180
[ [ "POWER TOOL AND METHOD FOR WIRELESS COMMUNICATION", "A power tool having multiple wireless communication states and a method of wirelessly communicating by a power tool.", "The power tool includes a motor, a battery pack interface that selectively receives a battery pack, a backup power source, and a wireless communication controller coupled to the backup power source and the battery pack interface.", "The wireless communication controller operates in a connectable state when coupled to a battery pack and transmits tool operational data to the external device and receives tool configuration data from the external device.", "The wireless communication controller operates in an advertisement state when the wireless communication controller is coupled to and powered by the backup power source.", "In the advertisement state, the wireless communication controller is configured to transmit the unique tool identifier.", "The external device may also display an indication of the communication state of the power tool." ], [ "1.A power tool comprising: a battery pack interface that selectively receives a battery pack; a wireless communication controller coupled to the battery pack interface and including a wireless transceiver and a processor, wherein the wireless communication controller is configured to determine that the battery pack interface is disconnected from the battery pack; enter an advertisement state for wireless communication based on determining that the battery pack interface is disconnected from the battery pack; and transmit an advertisement message including a unique tool identifier of the power tool when in the advertisement state.", "2.The power tool of claim 1, wherein the wireless communication controller is further configured to: determine that the battery pack interface is connected to the battery pack; form a wireless communication link with an external device; and communicate, over the wireless communication link, to one or more of transmit tool operational data and receive tool configuration data from the external device.", "3.The power tool of claim 1, further comprising: a real-time clock configured to maintain a current time and receive power from a backup power source; wherein the wireless communication controller receives a lock out time from an external device and the power tool is configured to lock upon the current time exceeding the lock out time.", "4.The power tool of claim 1, further comprising: a motor; a backup power source; a real-time clock coupled to the backup power source and configured to maintain a current time; a switching network coupled between the motor and the battery pack interface; an actuator; a controller coupled to the actuator and the switching network, the controller configured to control the switching network to apply power from the battery pack to drive the motor based on activation of the actuator, wherein the controller is unpowered when the battery pack is disconnected from the battery pack interface; wherein the wireless communication controller is configured to receive a lock out time; wherein the controller is configured to receive the lock out time from the wireless communication controller and the current time, and further configured to lock the power tool upon determining that the current time exceeds the lock out time.", "5.The power tool of claim 4, wherein the wireless communication controller receives the lock out time while the battery pack is coupled to the battery pack interface; wherein the battery pack is decoupled from the battery pack interface after the wireless communication controller receives the lock out time and prior to the current time exceeding the lock out time; wherein at least one of the battery pack and a second battery pack is coupled to the battery pack interface after the current time exceeds the lock out time; wherein the controller is configured to lock the power tool upon determining that the at least one of the battery pack and the second battery pack is coupled to the battery pack interface and that the current time exceeds the lock out time.", "6.The power tool of claim 1, further comprising: a backup battery receptacle configured to receive a backup power source; wherein the backup battery receptacle is blocked when the battery pack is connected to the battery pack interface and accessible when the battery pack is disconnected from the battery pack interface.", "7.The power tool of claim 1, further comprising: a housing having an upper main body, a handle, and a battery pack receiving portion including the battery pack interface and a backup battery receptacle, wherein the upper main body includes a motor and the handle is connected to the upper main body and to the battery pack receiving portion; and a backup power source located in the backup battery receptacle.", "8.The power tool of claim 1, wherein the wireless communication controller is further configured to enter a connectable state for wireless communication by: forming a wireless communication link with an external device; and communicating over the wireless communication link to one or more of transmit tool operational data to the external device and receive tool configuration data from the external device; wherein a user interface of the external device displays an icon that indicates that the wireless communication controller is in the connectable state.", "9.A power tool comprising: a battery pack interface that selectively receives a battery pack; a backup power source; and a wireless communication controller coupled to the backup power source and the battery pack interface, the wireless communication controller including a wireless transceiver and a processor, the wireless communication controller configured to operate in an advertisement state when the wireless communication controller is coupled to and powered by the backup power source, wherein, in the advertisement state, the wireless communication controller is configured to transmit an advertisement message including a charge level of the backup power source, wherein transmitting of the advertisement message in the advertisement state includes periodic broadcasting of the advertisement message.", "10.The power tool of claim 9, wherein the advertisement message further includes a unique tool identifier of the power tool.", "11.The power tool of claim 9, wherein the wireless communication controller is further configured to: determine that the battery pack interface is connected to the battery pack; form a wireless communication link with an external device; and communicate, over the wireless communication link, to one or more of transmit tool operational data and receive tool configuration data from the external device.", "12.The power tool of claim 9, further comprising: a real-time clock configured to maintain a current time and receive power from the backup power source; wherein the wireless communication controller receives a lock out time from an external device and the power tool is configured to lock upon the current time exceeding the lock out time.", "13.The power tool of claim 9, further comprising: a motor; a real-time clock coupled to the backup power source and configured to maintain a current time; a switching network coupled between the motor and the battery pack interface; an actuator; a controller coupled to the actuator and the switching network, the controller configured to control the switching network to apply power from the battery pack to drive the motor based on activation of the actuator, wherein the controller is unpowered when the battery pack is disconnected from the battery pack interface; wherein the wireless communication controller is configured to receive a lock out time; wherein the controller is configured to receive the lock out time from the wireless communication controller and the current time, and further configured to lock the power tool upon determining that the current time exceeds the lock out time.", "14.The power tool of claim 9, further comprising: a backup battery receptacle configured to receive the backup power source; wherein the backup battery receptacle is blocked when the battery pack is connected to the battery pack interface and accessible when the battery pack is disconnected from the battery pack interface.", "15.The power tool of claim 9, further comprising: a housing having an upper main body, a handle, and a battery pack receiving portion including the battery pack interface and a backup battery receptacle, wherein the upper main body includes a motor and the handle is connected to the upper main body and to the battery pack receiving portion; wherein the backup power source is located in the backup battery receptacle.", "16.The power tool of claim 9, wherein the wireless communication controller is further configured to enter a connectable state for wireless communication by: forming a wireless communication link with an external device; and communicating over the wireless communication link to one or more of transmit tool operational data to the external device and receive tool configuration data from the external device; wherein a user interface of the external device displays an icon that indicates that the wireless communication controller is in the connectable state.", "17.A power tool comprising: a housing having an upper main body, a handle, and a battery pack receiving portion; wherein the upper main body includes a motor and the handle is connected to the upper main body and to the battery pack receiving portion; wherein the battery pack receiving portion includes a battery pack interface that selectively receives a battery pack, and a backup battery receptacle; a backup power source located in the backup battery receptacle; and a wireless communication controller coupled to the backup power source, the wireless communication controller including a wireless transceiver, a processor, and a unique tool identifier, the wireless communication controller configured to operate in an advertisement state when the wireless communication controller is coupled to and powered by the backup power source.", "18.The power tool of claim 17, wherein, in the advertisement state, the wireless communication controller is configured to transmit an advertisement message including the unique tool identifier; wherein the wireless communication controller is configured to receive power from the battery pack when the battery pack is coupled to the battery pack interface.", "19.The power tool of claim 17, wherein the backup battery receptacle is blocked when the battery pack is connected to the battery pack interface and accessible when the battery pack is disconnected from the battery pack interface.", "20.The power tool of claim 17, further comprising: a real-time clock configured to maintain a current time and receive power from the backup power source; wherein the wireless communication controller is located in the backup battery receptacle and receives a lock out time from an external device; wherein the power tool is configured to lock upon the current time exceeding the lock out time.", "21.The power tool of claim 17, wherein the wireless communication controller is located in the battery pack receiving portion." ], [ "<SOH> FIELD OF THE INVENTION <EOH>The present invention relates to power tools that communicate wirelessly with an external device." ], [ "<SOH> SUMMARY <EOH>In one embodiment, a power tool is provided having multiple wireless communication states.", "The power tool includes a motor, a battery pack interface that selectively receives a battery pack, and a backup power source.", "The power tool further includes a wireless communication controller coupled to the backup power source and the battery pack interface.", "The wireless communication controller includes a wireless transceiver, a processor, and a unique tool identifier.", "Additionally, the wireless communication controller is configured to operate in a connectable state when the wireless communication controller is coupled to and powered by the battery pack.", "In the connectable state, the wireless communication controller is configured to form a wireless communication link with an external device and to one or more of transmit tool operational data to the external device and receive tool configuration data from the external device.", "The wireless communication controller is further configured to operate in an advertisement state when the wireless communication controller is coupled to and powered by the backup power source.", "In the advertisement state, the wireless communication controller is configured to transmit an advertisement message including the unique tool identifier.", "In another embodiment, a method of wirelessly communicating by a power tool is provided.", "The method includes, the method determining, by a wireless communication controller of the power tool, that the battery pack interface is connected to a battery pack.", "The wireless communication controller enters a connectable state for wireless communication based on determining that the battery pack interface is connected to the battery pack.", "The method further includes forming a wireless communication link with an external device in the connectable state, and communicating, over the wireless communication link, to one or more of transmit tool operational data and receive tool configuration data from the external device.", "The method also includes determining, by the wireless communication controller, that a battery pack interface is disconnected from the battery pack.", "The wireless communication controller enters an advertisement state for wireless communication based on determining that the battery pack interface is disconnected from the battery pack.", "The wireless communication controller further transmits an advertisement message including a unique tool identifier of the power tool when in the advertisement state.", "In another embodiment, a power tool having multiple wireless communication states is provided.", "The power tool includes a motor, a battery pack interface that selectively receives a battery pack and a backup power source.", "The power tool further includes a real-time clock, a wireless communication controller, and a controller.", "The real-time clock is coupled to the backup power source and configured to maintain a current time.", "The wireless communication controller is coupled to the backup power source and the battery pack interface; includes a wireless transceiver, a processor, and a unique tool identifier; and is configured to receive a lock out time.", "The controller is configured to receive the lock out time from the wireless communication controller and the current time.", "The controller is further configured to lock the power tool upon determining that the current time exceeds the lock out time.", "In one embodiment, the invention provides a cordless power tool including a drive device, a handle portion, a motor portion (e.g., an upper main body of a housing), a backup battery, and a real time clock.", "The handle portion of the power tool includes a foot of the power tool.", "The power tool is configured to receive a removable battery pack.", "The backup battery powers the real time clock even when the removable battery pack is detached from the tool.", "In some embodiments, the backup battery is positioned adjacent a Bluetooth module, and the Bluetooth module is positioned at the foot of the tool.", "In some embodiments, the backup battery is positioned within a pocket inside the power tool and is easily accessible for backup battery replacement when applicable.", "The pocket does not interfere with the attachable power tool battery pack and does not interfere with additional accessories (e.g., belt clip tool holder and bit holder).", "The pocket is positioned in an area of the power tool such that the backup battery is not damaged when the tool is dropped and impacts onto a hard surface.", "In another embodiment, the invention provides a method for identifying when different power tools are within a particular area (e.g., a general vicinity), and what tools, specifically, are present.", "The method further includes identifying to the user whether the power tool is in a connectable state or in an inaccessible state based on whether a battery pack is currently attached to the power tool.", "In one embodiment, the invention provides a power tool including a drive device for performing a task, a motor coupled to the drive device and configured to drive the drive device, a wireless communication controller having a real-time clock, a backup power source, a receiving portion configured to receive a main power source, and a controller.", "The controller is coupled to the motor, the wireless communication controller, and the main power source.", "The controller is configured to control the operation of the motor.", "Other aspects of the invention will become apparent by consideration of the detailed description and accompanying drawings." ], [ "RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/668,488, filed Aug. 3, 2017, which is a continuation of U.S. patent application Ser.", "No.", "15/146,535, filed May 4, 2016, now U.S. Pat.", "No.", "9,756,402, which claims priority to U.S.", "Provisional Patent Application No.", "62/190,295, filed on Jul 9, 2015, and U.S.", "Provisional Patent Application No.", "62/156,856, filed on May 4, 2015, the entire contents of which are hereby incorporated by reference.", "FIELD OF THE INVENTION The present invention relates to power tools that communicate wirelessly with an external device.", "SUMMARY In one embodiment, a power tool is provided having multiple wireless communication states.", "The power tool includes a motor, a battery pack interface that selectively receives a battery pack, and a backup power source.", "The power tool further includes a wireless communication controller coupled to the backup power source and the battery pack interface.", "The wireless communication controller includes a wireless transceiver, a processor, and a unique tool identifier.", "Additionally, the wireless communication controller is configured to operate in a connectable state when the wireless communication controller is coupled to and powered by the battery pack.", "In the connectable state, the wireless communication controller is configured to form a wireless communication link with an external device and to one or more of transmit tool operational data to the external device and receive tool configuration data from the external device.", "The wireless communication controller is further configured to operate in an advertisement state when the wireless communication controller is coupled to and powered by the backup power source.", "In the advertisement state, the wireless communication controller is configured to transmit an advertisement message including the unique tool identifier.", "In another embodiment, a method of wirelessly communicating by a power tool is provided.", "The method includes, the method determining, by a wireless communication controller of the power tool, that the battery pack interface is connected to a battery pack.", "The wireless communication controller enters a connectable state for wireless communication based on determining that the battery pack interface is connected to the battery pack.", "The method further includes forming a wireless communication link with an external device in the connectable state, and communicating, over the wireless communication link, to one or more of transmit tool operational data and receive tool configuration data from the external device.", "The method also includes determining, by the wireless communication controller, that a battery pack interface is disconnected from the battery pack.", "The wireless communication controller enters an advertisement state for wireless communication based on determining that the battery pack interface is disconnected from the battery pack.", "The wireless communication controller further transmits an advertisement message including a unique tool identifier of the power tool when in the advertisement state.", "In another embodiment, a power tool having multiple wireless communication states is provided.", "The power tool includes a motor, a battery pack interface that selectively receives a battery pack and a backup power source.", "The power tool further includes a real-time clock, a wireless communication controller, and a controller.", "The real-time clock is coupled to the backup power source and configured to maintain a current time.", "The wireless communication controller is coupled to the backup power source and the battery pack interface; includes a wireless transceiver, a processor, and a unique tool identifier; and is configured to receive a lock out time.", "The controller is configured to receive the lock out time from the wireless communication controller and the current time.", "The controller is further configured to lock the power tool upon determining that the current time exceeds the lock out time.", "In one embodiment, the invention provides a cordless power tool including a drive device, a handle portion, a motor portion (e.g., an upper main body of a housing), a backup battery, and a real time clock.", "The handle portion of the power tool includes a foot of the power tool.", "The power tool is configured to receive a removable battery pack.", "The backup battery powers the real time clock even when the removable battery pack is detached from the tool.", "In some embodiments, the backup battery is positioned adjacent a Bluetooth module, and the Bluetooth module is positioned at the foot of the tool.", "In some embodiments, the backup battery is positioned within a pocket inside the power tool and is easily accessible for backup battery replacement when applicable.", "The pocket does not interfere with the attachable power tool battery pack and does not interfere with additional accessories (e.g., belt clip tool holder and bit holder).", "The pocket is positioned in an area of the power tool such that the backup battery is not damaged when the tool is dropped and impacts onto a hard surface.", "In another embodiment, the invention provides a method for identifying when different power tools are within a particular area (e.g., a general vicinity), and what tools, specifically, are present.", "The method further includes identifying to the user whether the power tool is in a connectable state or in an inaccessible state based on whether a battery pack is currently attached to the power tool.", "In one embodiment, the invention provides a power tool including a drive device for performing a task, a motor coupled to the drive device and configured to drive the drive device, a wireless communication controller having a real-time clock, a backup power source, a receiving portion configured to receive a main power source, and a controller.", "The controller is coupled to the motor, the wireless communication controller, and the main power source.", "The controller is configured to control the operation of the motor.", "Other aspects of the invention will become apparent by consideration of the detailed description and accompanying drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a communication system according to one embodiment of the invention.", "FIG.", "2 illustrates an external device of the communication system.", "FIG.", "3 illustrates a power tool of the communication system.", "FIG.", "4 illustrates selection switches of the power tool.", "FIG.", "5 illustrates a battery pack receiving portion of the power tool.", "FIGS.", "6A-B illustrate a schematic diagram of the power tool.", "FIG.", "7 is a flowchart illustrating a method of changing settings associated with a security feature.", "FIG.", "8 illustrates an exemplary screenshot of a user interface of an external device of the communication system.", "FIG.", "9 illustrates an exemplary home screen for a power tool.", "FIGS.", "10A-D illustrate exemplary security screens for the power tool.", "FIG.", "11 illustrates an exemplary scheduled lock screen for the power tool.", "FIGS.", "12A-E illustrate a backup power source of the power tool.", "FIG.", "13 illustrates a schematic diagram of alternative locations for the backup power source.", "FIG.", "14 illustrates a method of operating the power tool.", "FIG.", "15 illustrates a method of wirelessly communicating by the power tool DETAILED DESCRIPTION Before any embodiments of the invention are explained in detail, it is to be understood that the invention is not limited in its application to the details of construction and the arrangement of components set forth in the following description or illustrated in the following drawings.", "The invention is capable of other embodiments and of being practiced or of being carried out in various ways.", "Also, it is to be understood that the phraseology and terminology used herein is for the purpose of description and should not be regarded as limited.", "The use of “including,” “comprising” or “having” and variations thereof herein is meant to encompass the items listed thereafter and equivalents thereof as well as additional items.", "The terms “mounted,” “connected” and “coupled” are used broadly and encompass both direct and indirect mounting, connecting and coupling.", "Further, “connected” and “coupled” are not restricted to physical or mechanical connections or couplings, and can include electrical connections or couplings, whether direct or indirect.", "It should be noted that a plurality of hardware and software based devices, as well as a plurality of different structural components may be utilized to implement the invention.", "Furthermore, and as described in subsequent paragraphs, the specific configurations illustrated in the drawings are intended to exemplify embodiments of the invention and that other alternative configurations are possible.", "The terms “processor” “central processing unit” and “CPU” are interchangeable unless otherwise stated.", "Where the terms “processor” or “central processing unit” or “CPU” are used as identifying a unit performing specific functions, it should be understood that, unless otherwise stated, those functions can be carried out by a single processor, or multiple processors arranged in any form, including parallel processors, serial processors, tandem processors or cloud processing/cloud computing configurations.", "FIG.", "1 illustrates a communication system 100.The communication system 100 includes power tool devices 104a, 104b, and 104c, each generically referred to as the power tool 104, and an external device 108.The power tool 104 and the external device 108 can communicate wirelessly while they are within a communication range of each other.", "The power tool 104 may communicate power tool status, power tool operation statistics, power tool identification, stored power tool usage information, power tool maintenance data, and the like.", "Therefore, using the external device 108, a user can access stored power tool usage or power tool maintenance data.", "With this tool data, a user can determine how the power tool 104 has been used, whether maintenance is recommended or has been performed in the past, and identify malfunctioning components or other reasons for certain performance issues.", "The external device 108 can also transmit data to the power tool 104 for power tool configuration, firmware updates, or to send commands (e.g., turn on a work light, lock power tool 104, and the like).", "The external device 108 also allows a user to set operational parameters, safety parameters, select tool modes, and the like for the power tool 104.The external device 108 may be, for example, a laptop computer, a tablet computer, a smartphone, a cellphone, or another electronic device capable of communicating wirelessly with the power tool 104 and providing a user interface.", "The external device 108 provides the user interface and allows a user to access and interact with tool information.", "The external device 108 can receive user inputs to determine operational parameters, enable or disable features, and the like.", "The user interface of the external device 108 provides an easy-to-use interface for the user to control and customize operation of the power tool 104.As shown in FIG.", "2, the external device 108 includes an external device processor 114, a short-range transceiver 118, a network communication interface 122, a touch display 126, and a memory 130.The external device processor 114 is coupled to the short-range transceiver 118, the network communication interface 122, the touch display 126, and the memory 130.The short-range transceiver 118, which may include or is coupled to an antenna (not shown), is configured to communicate with a compatible transceiver within the power tool 104.The short-range transceiver 118 can also communicate with other electronic devices.", "The network communication interface 122 communicates with a network to enable communication with the remote server 112.The network communication interface 122 may include circuitry that enables the external device 108 to communicate with the network.", "In some embodiments, the network may be an Internet network, a cellular network, another network, or a combination thereof.", "The memory 130 of the external device 108 also stores core application software 134.The external device processor 114 accesses and executes the core application software 134 in memory 130 to launch a control application.", "After the external device 108 launches the control application, the external device 108 receives inputs from the user (e.g., via the touch display 126).", "In response to the inputs, the external device 108 communicates with the power tool 104 to update software in the power tool 104.Through these updates, a user is able to define the operation of the power tool 104.In some embodiments, the external device 108 also communicates with the remote server 112 to provide information regarding the operation of the power tool 104 and the like.", "The external device 108 includes the short-range transceiver 118, which is compatible with a wireless communication interface or module of the power tool 104.The communication interface of the external device 108 may include a wireless communication controller (e.g., a Bluetooth® module), or a similar component.", "The external device 108, therefore, grants the user access to data related to the power tool 104, and provides a user interface such that the user can interact with the controller of the power tool 104.In addition, the external device 108 can also share the information obtained from the power tool 104 with the remote server 112.The remote server 112 may be used to store the data obtained from the external device 108, provide additional functionality and services to the user, or a combination thereof.", "In one embodiment, storing the information on the remote server 112 allows a user to access the information from a plurality of different devices and locations (e.g., a remotely located desktop computer).", "In another embodiment, the remote server 112 may collect information from various users regarding their power tool devices and provide statistics or statistical measures to the user based on information obtained from the different power tools.", "For example, the remote server 112 may provide statistics regarding the experienced efficiency of the power tool 104, typical usage of the power tool 104, and other relevant characteristics and/or measures of the power tool 104.In some embodiments, the power tool 104 may be configured to communicate directly with the server 112 through an additional wireless interface or with the same wireless interface that the power tool 104 uses to communicate with the external device 108.The power tool 104 is configured to perform one or more specific tasks (e.g., drilling, cutting, fastening, pressing, lubricant application, sanding, heating, grinding, bending, forming, impacting, polishing, lighting, etc.).", "For example, an impact wrench is associated with the task of generating a rotational output (e.g., to drive a bit), while a reciprocating saw is associated with the task of generating a reciprocating output motion (e.g., for pushing and pulling a saw blade).", "The task(s) associated with a particular tool may also be referred to as the primary function(s) of the tool.", "Although the power tool 104 illustrated and described herein is an impact wrench, embodiments of the invention similarly apply to and can be used in conjunction with a variety of power tools (e.g., a power drill, a hammer drill, a pipe cutter, a sander, a nailer, a grease gun, etc.).", "As shown in FIG.", "3, the power tool 104 includes an upper main body 202, a handle 204, a battery pack receiving portion 206, selection switch 208, an output drive device or mechanism 210, and a trigger 212 (or other actuator).", "The housing of the power tool 104 (e.g., the main body 202 and the handle 204) are composed of a durable and light-weight plastic material.", "The drive device 210 is composed of a metal (e.g., steel).", "The drive device 210 on the power tool 104 is a socket.", "However, each power tool 104 may have a different drive device 210 specifically designed for the task associated with the power tool 104.For example, the drive device 210 for a power drill may include a bit driver, while the drive device 210 for a pipe cutter may include a blade.", "The selection switch 208 is configured to select the speed and/or torque mode for the power tool 104.For instance, different modes stored on the power tool 104 may have different speed or torque levels, and pressing the selection switch 208 cycles between the different modes of the power tool 104.For embodiments in which the power tool 104 is different than the impact wrench 104, the different modes may be related to settings for other parameters such as, for example, crimping pressures for crimpers.", "FIG.", "4 illustrates a more detailed view of the selection switch 208.FIG.", "5 illustrates the battery pack receiving portion 206.The battery pack receiving portion 206 is configured to receive and couple to a battery pack 215 (for example, power tool device 104b illustrated in FIG.", "1) that provides power to the power tool 104.The battery pack 215 may also be referred to as a main power source 215.The battery pack receiving portion 206 includes a connecting structure to engage a mechanism that secures the battery pack 215 and a terminal block 270 to electrically connect the battery pack 215 to the power tool 104.In the illustrated embodiment, the connecting structure includes guides 207 and notches 209 (see FIGS.", "12B and 12C) to secure the battery pack to the power tool 104.The terminal block 270 includes terminals 275 that make contact with terminals of the battery pack 215 when the battery pack 215 is coupled to the battery pack receiving portion 206.Such contact allows for the power tool 104 to be electrically connected to the battery pack 215.FIG.", "6A illustrates a block diagram of some embodiments of the power tool 104, such as those with motors (e.g., the impact driver 104a of FIG.", "1).", "As shown in FIG.", "6A, the power tool 104 also includes a motor 214.The motor 214 actuates the drive device 210 and allows the drive device 210 to perform the particular task.", "The primary power source (e.g., the battery pack) 215 couples to the power tool 104 and provides electrical power to energize the motor 214.The motor 214 is energized based on the position of the trigger 212.When the trigger 212 is depressed the motor 214 is energized, and when the trigger 212 is released, the motor 214 is de-energized.", "In the illustrated embodiment, the trigger 212 extends partially down a length of the handle 204; however, in other embodiments the trigger 212 extends down the entire length of the handle 204 or may be positioned elsewhere on the power tool 104.The trigger 212 is moveably coupled to the handle 204 such that the trigger 212 moves with respect to the tool housing.", "The trigger 212 is coupled to a push rod, which is engageable with a trigger switch 213 (see FIG.", "6A).", "The trigger 212 moves in a first direction towards the handle 204 when the trigger 212 is depressed by the user.", "The trigger 212 is biased (e.g., with a spring) such that it moves in a second direction away from the handle 204, when the trigger 212 is released by the user.", "When the trigger 212 is depressed by the user, the push rod activates the trigger switch 213, and when the trigger 212 is released by the user, the trigger switch 213 is deactivated.", "In other embodiments, the trigger switch 213 is an electrical trigger switch 213, and the trigger 212 is coupled to the electrical trigger switch 213.In such embodiments, the trigger switch 213 may include, for example, a transistor.", "Additionally, for such electronic embodiments, the trigger 212 may not include a push rod to activate the mechanical switch.", "Rather, the electrical trigger switch 213 may be activated by, for example, a position sensor (e.g., a Hall-Effect sensor) that relays information about the relative position of the trigger 212 to the electrical trigger switch 213.As shown in FIG.", "6A, the power tool 104 also includes a switching network 216, sensors 218, indicators 220, a battery pack interface 222, a power input unit 224, a controller 226, a wireless communication controller 250, a backup power source 252, and a real-time clock (RTC) 260.In some embodiments, the RTC 260 is part of the wireless communication controller 250 as shown in FIG.", "6B.", "Additionally, in some embodiments, the wireless communication controller 250 may be combined to be a component of the controller 226.The battery pack interface 222 is coupled to the controller 226 and couples to the battery pack 215.The battery pack interface 222 includes a combination of mechanical (e.g., the battery pack receiving portion 206) and electrical components configured to and operable for interfacing (e.g., mechanically, electrically, and communicatively connecting) the power tool 104 with a battery pack 215.The battery pack interface 222 is coupled to the power input unit 224.The battery pack interface 222 transmits the power received from the battery pack 215 to the power input unit 224.The power input unit 224 includes combinations of active and passive components (e.g., voltage step-down controllers, voltage converters, rectifiers, filters, etc.)", "to regulate or control the power received through the battery pack interface 222 and provided to the wireless communication controller 250 and controller 226.The switching network 216 enables the controller 226 to control the operation of the motor 214.Generally, when the trigger 212 is depressed (i.e., the trigger switch 213 is closed), electrical current is supplied from the battery pack interface 222 to the motor 214, via the switching network 216.When the trigger 212 is not depressed, electrical current is not supplied from the battery pack interface 222 to the motor 214.In some embodiments, the trigger switch 213 may include sensors to detect the amount of trigger pull (e.g., released, 20% pull, 50% pull, 75% pull, or fully depressed).", "In some embodiments, the amount of trigger pull detected by the trigger switch 213 is related to or corresponds to a desired speed of rotation of the motor 214.In other embodiments, the amount of trigger pull detected by the trigger switch 213 is related to or corresponds to a desired torque.", "In response to the controller 226 receiving the activation signal from the trigger switch 213, the controller 226 activates the switching network 216 to provide power to the motor 214.The switching network 216 controls the amount of current available to the motor 214 and thereby controls the speed and torque output of the motor 214.The switching network 216 may include numerous field effect transistors (FETs), bipolar transistors, or other types of electrical switches.", "The sensors 218 are coupled to the controller 226 and communicate to the controller 226 various signals indicative of different parameters of the power tool 104 or the motor 214.The sensors 218 include, for example, one or more current sensors, one or more voltage sensors, one or more temperature sensors, one or more speed sensors, one or more Hall Effect sensors, etc.", "For example, the speed of the motor 214 can be determined using a plurality of Hall Effect sensors to sense the rotational position of the motor 214.In some embodiments, the controller 226 controls the switching network 216 in response to signals received from the sensors 218.For example, if the controller 226 determines that the speed of the motor 214 is increasing too rapidly based on information received from the sensors 218, the controller 226 may adapt or modify the active switches or switching sequence within the switching network 216 to reduce the speed of the motor 214.Data obtained via the sensors 218 may be saved in the controller 226 as tool usage data.", "The indicators 220 are also coupled to the controller 226 and receive control signals from the controller 226 to turn on and off or otherwise convey information based on different states of the power tool 104.The indicators 220 include, for example, one or more light-emitting diodes (“LED”), or a display screen.", "The indicators 220 can be configured to display conditions of, or information associated with, the power tool 104.For example, the indicators 220 are configured to indicate measured electrical characteristics of the power tool 104, the status of the power tool 104, etc.", "The indicators 220 may also include elements to convey information to a user through audible or tactile outputs.", "As described above, the controller 226 is electrically and/or communicatively connected to a variety of modules or components of the power tool 104.In some embodiments, the controller 226 includes a plurality of electrical and electronic components that provide power, operational control, and protection to the components and modules within the controller 226 and/or power tool 104.For example, the controller 226 includes, among other things, a processing unit 230 (e.g., a microprocessor, a microcontroller, or another suitable programmable device), a memory 232, input units 234, and output units 236.The processing unit 230 includes, among other things, a control unit 240, an arithmetic logic unit (“ALU”) 242, and a plurality of registers 244 (shown as a group of registers in FIG.", "6A).", "In some embodiments, the controller 226 is implemented partially or entirely on a semiconductor (e.g., a field-programmable gate array [“FPGA”] semiconductor) chip, such as a chip developed through a register transfer level (“RTL”) design process.", "The memory 232 includes, for example, a program storage area 233a and a data storage area 233b.", "The program storage area 233a and the data storage area 233b can include combinations of different types of memory, such as read-only memory (“ROM”), random access memory (“RAM”) (e.g., dynamic RAM [“DRAM”], synchronous DRAM [“SDRAM”], etc.", "), electrically erasable programmable read-only memory (“EEPROM”), flash memory, a hard disk, an SD card, or other suitable magnetic, optical, physical, or electronic memory devices.", "The processing unit 230 is connected to the memory 232 and executes software instructions that are capable of being stored in a RAM of the memory 232 (e.g., during execution), a ROM of the memory 232 (e.g., on a generally permanent basis), or another non-transitory computer readable medium such as another memory or a disc.", "Software included in the implementation of the power tool 104 can be stored in the memory 232 of the controller 226.The software includes, for example, firmware, one or more applications, program data, filters, rules, one or more program modules, and other executable instructions.", "The controller 226 is configured to retrieve from memory and execute, among other things, instructions related to the control processes and methods described herein.", "The controller 226 is also configured to store power tool information on the memory 232.The power tool information stored on the memory 232 may include power tool identification information (e.g., including a unique identifier of the power tool 104) and also power tool operational information including information regarding the usage of the power tool 104, information regarding the maintenance of the power tool 104, power tool trigger event information, and other information relevant to operating or maintaining the power tool 104.Such power tool information may then be accessed by a user with the external device 108.In other constructions, the controller 226 includes additional, fewer, or different components.", "The wireless communication controller 250 is coupled to the controller 226.In the illustrated embodiment, the wireless communication controller 250 is located near the foot of the power tool 104 (see FIG.", "3) to save space and ensure that the magnetic activity of the motor 214 does not affect the wireless communication between the power tool 104 and the external device 108.As a particular example, in some embodiments, the wireless communication controller 250 is positioned under the user interface 261 on the foot of the power tool 104, which includes the mode selection switch 208 and an example of the indicators 220 (in the form of a mode indicator) in a recess spanning a dividing line of the power tool's clam shell housing.", "As shown in FIG.", "6B, the wireless communication controller 250 includes an antenna and radio transceiver 254, a memory 256, a processor 258, and a real-time clock (RTC) 260.The antenna and radio transceiver 254 operate together to send and receive wireless messages to and from an external device 108 and the processor 258.The memory 256 can store instructions to be implemented by the processor 258 and/or may store data related to communications between the power tool 104 and the external communication device 108 or the like.", "The processor 258 for the wireless communication controller 250 controls wireless communications between the power tool 104 and the external device 108.For example, the processor 258 associated with the wireless communication controller 250 buffers incoming and/or outgoing data, communicates with the controller 226, and determines the communication protocol and/or settings to use in wireless communications.", "In the illustrated embodiment, the wireless communication controller 250 is a Bluetooth® controller.", "The Bluetooth® controller communicates with the external device 108 employing the Bluetooth® protocol.", "Therefore, in the illustrated embodiment, the external device 108 and the power tool 104 are within a communication range (i.e., in proximity) of each other while they exchange data.", "In other embodiments, the wireless communication controller 250 communicates using other protocols (e.g., Wi-Fi, cellular protocols, etc.)", "over a different type of wireless network.", "For example, the wireless communication controller 250 may be configured to communicate via Wi-Fi through a wide area network such as the Internet or a local area network, or to communicate through a piconet (e.g., using infrared or NFC communications).", "The communication via the wireless communication controller 250 may be encrypted to protect the data exchanged between the power tool 104 and the external device 108 (or network) from third parties.", "In the illustrated embodiment, the wireless communication controller 250 is configured to periodically broadcast an identification signal, also referred to as identification information or identification data.", "The identification signal includes identification information for the power tool 104, such as a unique identifier.", "The external device 108 identifies the power tool 104 via the identification signal.", "Additionally or alternatively, the wireless communication controller 250 may be configured to respond to a ping signal from the external device 108.In other words, the wireless communication controller 250 may not periodically broadcast the identification signal, but rather the wireless communication controller 250 may wait for a ping signal from the external device 108 to send the identification signal.", "The wireless communication controller 250 is configured to receive data from the power tool controller 226 and relay the information to the external device 108 via the antenna and transceiver 254.In a similar manner, the wireless communication controller 250 is configured to receive information (e.g., configuration and programming information) from the external device 108 via the antenna and transceiver 254 and relay the information to the power tool controller 226.The RTC 260 increments and keeps time independently of the other power tool components.", "In the illustrated embodiment, the RTC 260 is powered through the wireless communication controller 250 when the wireless communication controller 250 is powered.", "In some embodiments, however, the RTC 260 is a separate component from the wireless communication controller 250.In such embodiments, the RTC 260 receives power from the battery pack 215 (e.g., a main or primary power source) when the battery pack 215 is connected to the power tool 104.The RTC 260 receives power from the backup power source 252 (e.g., a coin cell battery, another type of battery cell, a capacitor, or another energy storage device) when the battery pack 215 is not connected to the power tool 104.Therefore, the RTC 260 keeps track of time regardless of whether the power tool 104 is in operation, and regardless of whether the battery pack 215 is connected to the power tool 104.When no power source is present (i.e., the battery pack 215 is detached from the power tool 104 and the backup power source 252 is removed or depleted), the RTC 260 stores the last valid time.", "When a power source is replaced (i.e., the battery pack 215 is attached to the power tool 104 and/or the backup power source 252 is replaced), the RTC 260 uses the stored time as a starting point to resume keeping time.", "The starting time for the RTC 260 is set to current Greenwich mean time (GMT) time at the factory at time of manufacture.", "The time is updated or synchronized whenever the wireless communication controller 250 communicates with the external device 108.Because GMT time is independent of calendar, seasons, or time schemas, using GMT time allows the power tool 104 or the external device 108 to convert from time indicated by the RTC 260 to localized time for display to the user.", "Because the RTC 260 is able to maintain accurate time whether or not the battery pack 215 is attached to the power tool 104, the RTC 260 is configured to time-stamp (i.e., associate a specific time with) the operational data of the power tool 104.For example, the controller 226 can store the operational data when, for example, the power tool 104 is fastening a group of fasteners.", "The controller 226 then receives an indication of time (e.g., a GMT time) from the RTC 260 or from the processor 258 associated with the wireless communication controller 250.The controller 226 proceeds to store the operational data (e.g., the torque output by the power tool 104, the speed of the motor 214, the number of trigger pulls, etc.)", "with a time-stamp provided based on the received time from the RTC 260.The RTC 260 can continuously or periodically provide an indication of time to the controller 226.In other embodiments, the controller 226 requests a time signal from the processor 258 of the wireless communication controller 250 and waits for the time signal from the RTC 260.The RTC 260 also allows the controller 226 to keep track of maintenance and/or service schedules.", "For example, maintenance for a particular tool may be scheduled once every year.", "The maintenance time or date can be stored in the memory 232 or 256 and the controller 226 or 250 periodically compares the time from the RTC 260 to the stored maintenance time or date and generates an alert when the date/time is reached.", "The alert can be sent to the external device 108 and/or be signaled via indicators 220.The RTC 260 also enables the power tool 104 to implement a time-based lock-out feature.", "In the time-based lock-out feature, the memory 232 or 256 may also store a security date and time information or a timer amount.", "The controller 226 monitors the time received from the RTC 260 and compares the current time from the RTC 260 to the user-specified lock-out time stored in the memory 232 or 256.When the current time from the RTC 260 exceeds the user-specified lock-out time, the controller 226 locks the power tool 104 (e.g., the power tool 104 is disabled such that driving the motor 214 is prevented).", "The power tool 104, therefore, becomes inoperable.", "Since the RTC 260 keeps time independent of other components in the power tool 104 and independent of the operation of the power tool 104, the controller 226 can more accurately track when maintenance or service for a particular tool or a particular part is due and/or when a specified time for a security feature is approaching.", "The processor 258 of the wireless communication controller 250 switches between operating in a connectable (e.g., full power) state and operating in an advertisement state.", "The wireless communication controller 250 operates in the connectable state when the battery pack 215 is attached to the power tool 104 and contains sufficient charge to power the wireless communication controller 250 and the controller 226, and to support substantive electronic data communication between the power tool 104 and the external device 108.When the wireless communication controller 250 operates in the connectable state, wireless communication between the power tool 104 and the external device 108 is enabled.", "In the connectable state, the wireless communication controller 250 obtains and exports tool operational data including tool usage data, maintenance data, mode information, drive device information, and the like from the power tool 104.The exported operational data is received by the external device 108 and can be used by tool users or owners to log operational data related to a particular power tool 104 or to specific job activities.", "The exported and logged operational data can indicate when work was accomplished and that work was accomplished to specification.", "The logged operational data can also provide a chronological record of work that was performed, track duration of tool usage, and the like.", "In the connectable state, the wireless communication controller 250 also imports (i.e., receives) configuration data from the external device 108 into the power tool 104 such as, for example, operation thresholds, maintenance thresholds, mode configurations, programming for the power tool 104, feature information, and the like.", "The configuration data is provided by the wireless communication controller 250 to the controller 226 over communication channel 262, and the processing unit 230 stores the configuration data in the memory 232.The processing unit 230 further accesses the configuration data stored in the memory 232 and controls driving of the motor 214 in accordance with the configuration data.", "For example, the processing unit 230 may drive the motor 214 at a particular speed or until a particular torque is reached (e.g., as detected by the sensors 218), where the particular speed or torque is provided as part of the configuration data.", "If the battery pack 215 is not connected to the wireless communication controller 250 or if the battery pack 215 is depleted, the wireless communication controller 250 operates in the advertisement state.", "While in the advertisement state, the wireless communication controller 250 receives power from the backup power source 252 (e.g., a coin cell battery, another type of battery cell, a capacitor, or another energy storage device).", "The backup power source 252 provides sufficient power for the wireless communication controller 250 to periodically broadcast an advertisement message, but may not provide sufficient power to allow the wireless communication controller 250 to engage in further data exchange with the external device 108, or, such further data exchange would deplete the backup power source 252 more rapidly than desired.", "In other words, the communication capabilities of the power tool 104 are limited or restricted when the wireless communication controller 250 is in the advertisement state.", "In some embodiments, when the wireless communication controller 250 operates in the connectable state, the backup power source 252 does not provide power to the wireless communication controller 250 and battery life of the backup power source 252 is therefore extended.", "The external device 108 can enable a security feature of the power tool 104.In such embodiments, a user enables the security feature through the control application executed by the external device 108.The external device 108 then communicates with the wireless communication controller 250 to indicate to the power tool 104 that the user has enabled the security feature.", "FIG.", "7 illustrates an exemplary method 700 for enabling and implementing the security feature.", "The control application receives user instructions to search for the power tools 104 (or power tool devices) that are within the communication range of the external device 108 (at block 264).", "The control application determines which power tools 104 are within the communication range based on the advertisement messages broadcasted by the power tools 104 and received by the external device 108.The external device 108 identifies to the user which power tools 104 are within the communication range by displaying a tool icon 268 for each power tool within the communication range, as shown in FIG.", "8 (at block 272).", "The tool icon 268 includes an icon image and accompanying identification text data for each power tool (e.g., Steve's Drill).", "The icon image may be a photograph obtained from, for example, the manufacturer that represents the selected power tool 104, and/or the icon image may be a photograph obtained from the user that represents the power tool 104.The external device 108 also identifies to the user whether the power tool 104 is in the connectable state or in the advertisement state (i.e., the status of the power tool 104).", "This identification by the external device 108 indicates to the user the identity of power tools 104 that are within the communication range of the external device 108, the state of each power tool 104 that is within communication range, and whether substantive data exchange can occur between each of the power tools 104 and the external device 108.In some embodiments, the icon 268 representing the power tool 104 on the graphical user interface of the external device 108 changes based on the mode of the power tool 104.For example, in the some embodiments, the icon 268 for the power tool 104 is white on blue when the power tool 104 is in the connectable state, and gray on white when the power tool 104 is in the advertisement state.", "Stated another way, the text or icons corresponding to power tools 104 in the advertisement state may be displayed in a grayed-out or faded manner (see, e.g., symbol 269a) relative to power tools in the connectable state (see, e.g., symbol 269b).", "In other embodiments, the specific icons 268 corresponding to the connectable state and to the advertisement state may be different (e.g., in shape, symbol, or text), rather than merely in color, and the icon 268 corresponding to the connectable state is distinguishable from the icon corresponding to the advertisement state.", "The icons 268 can have different tool colors, background colors, symbols, letters, and the like depending on the state of the power tool 104 (e.g., connectable state or advertisement state).", "The icons 268 can flash, not flash, or flash at different frequency depending on whether the power tool 104 is in the connectable state or the advertisement state.", "Additionally, in some embodiments, the external device 108 also displays different icons 268 for other states of the power tool 104.For example, if the power tool 104 is in operation (i.e., the motor 214 is running or has been run recently), the external device 108 displays a first icon.", "If the power tool 104 is in the connectable state but not in operation, the external device 108 displays a second icon.", "If the power tool 104 is in the advertisement state and the backup power source 252 holds sufficient power, the external device 108 displays a third icon.", "The external device 108 may display a fourth icon if the backup power source 252 is low, and a fifth icon if the tool 104 experiences intermittent communication.", "Additionally, the icon 268 may change corresponding to how many seconds have passed since the advertisement or communication was last received from the power tool 104.The external device 108 determines the state of the power tool 104 based on the information it receives from the power tool 104.For example, in some embodiments, when the power tool 104 is in operation, the wireless communication controller 250 sends a corresponding signal to the external device 108 indicating that the motor 214 is currently operating.", "As another example, when the power tool 104 is in the advertisement state (i.e., the battery pack 215 is detached from the power tool 104), the wireless communication controller 250 sends a corresponding advertisement message to the external device 108.The external device 108 determines the state of the power tool 104 based on the received signal and changes the icons 268 according to the determined state of the power tool 104.When the wireless communication controller 250 operates in the advertisement state, the power tool 104 identifies itself to the external device 108, but data exchange between the power tool 104 and the external device 108 is limited to select information.", "In other words, in the advertisement state, the wireless communication controller 250 outputs an advertisement message to the external device 108.The advertisement message includes one or more of identification information regarding the tool identity (e.g., a serial number or other unique tool identifier), remaining capacity of the backup power source 252, and other limited amount of power tool information (e.g., configuration information used by third-party smartphone applications).", "The advertisement message also identifies the product as being from a particular manufacturer or brand via a global unique identification (GUID) that includes the power tool's specific make, model, and serial number.", "Even when operating in the advertisement state, the external device 108 can identify the power tool 104 and determine that the power tool 104 is within a communication range of the external device 108 (e.g., locate the power tool 104) based on the advertisement message, but further data between the external device 108 and the power tool 104 is not exchanged.", "The tool identification also allows for specific identification of power tools to differentiate between different power tools of the same module.", "Based on the displayed list of power tools 104, the user selects a particular tool 104 to enable the security feature.", "Returning to FIG.", "7, the control application running on the external device 108 receives the user's selection of the particular power tool 104 (at block 274).", "In response to receiving the user's selection of the particular power tool 104, the control application running on the external device 108 displays a home screen 276 particular to the selected power tool 104, as shown in FIG.", "9 (at block 278).", "The home screen 276 for the selected power tool 104 allows the user to control different aspects of the power tool 104.For example, in the illustrated embodiment, the control application enables the user to view, assign, and adjust tool settings to different power tool modes.", "The control application also enables the user to customize, assign, and share tool profiles.", "The control application also enables the user to enable and customize lock-out settings for the power tool 104.In particular, a user can select to expand the menu associated with the security feature (e.g., “SECURITY FEATURES”) to change and/or update the settings associated with the lock-out feature.", "Returning to FIG.", "7, the control application receives the user selection of the “SECURITY FEATURES” option (i.e., the security menu) (at block 280).", "In response to receiving the user selection of the security menu, the control application displays a security screen 282, as shown in FIG.", "10A-10D (at block 283).", "As shown in FIGS.", "10A-B, the security screen 282 includes an on/off indicator 284, a current status indicator 286, and a scheduled lock option 288.The on/off indicator 284 indicates the general setting for the security feature.", "The on/off indicator 284 is movable between an ON position and an OFF position.", "As shown in FIG.", "10A, when the on/off indicator 284 is in the OFF position, the lock-out feature is disabled and the power tool 104 can operate openly without restrictions from the security feature.", "When the security feature is disabled, the current status indicator 286 and the scheduled lock option 288 are grayed out and disabled.", "In other words, the control application disables the user's ability to change the current security status of the power tool 104 and/or set a scheduled lock when the security feature is disabled.", "In FIG.", "10A, to indicate that the current status indicator 286 and the scheduled lock option 288 are disabled, these items are shown in hollowed blocked letters.", "If, on the other hand, the on/off indicator 284 is in the ON position, as shown in FIG.", "10B, the lock-out feature is enabled and the user can specify different settings of the security feature.", "The security screen 282 indicates the current security status of the power tool 104 using a current status indicator 286.The security feature enables two types of security control.", "The first security control is a direct control of the power tool operation regulated by a current status selector 287.The second security control is regulated by the scheduled lock options 288.The current status selector 287 allows the user to change the current security status of the power tool 104.For example, the external device 108 may receive a user selection via the current status selector 287 to switch the current status of the power tool 104 between unlocked and locked.", "The current status selector 287 shows the opposite option as the current status of the power tool 104.For example, when the current status of the power tool 104 is “locked,” the current status selector 287 shows an option to “unlock” the power tool 104.In contrast, when the current status of the power tool 104 is “unlocked,” the current status selector 287 shows an option to “lock” the power tool 104.The current status selector 287 provides a binary option for switching the power tool 104 between an operable state and a locked-out state.", "In the illustrated example of FIG.", "10B, the current status of the power tool 104 is “locked.” Therefore, the power tool 104 is restricted in its operation and is currently under lock-out (e.g., not enabled to operate).", "In some embodiments, the power tool 104 may be under lock-out by providing minimal power to the motor 214 of the power tool 104.In other embodiments, the power tool 104 may be under lock-out by inhibiting electrical power from reaching the motor 214 of the power tool 104, thereby rendering the power tool 104 inoperable.", "While the current status of the power tool 104 is “locked,” the scheduled lock option 288 is grayed out and unavailable for user selection.", "In FIG.", "10B, to indicate that the scheduled lock option 288 is not available for selection, it is shown in hollowed blocked letters.", "On the other hand, the current status selector 287 is shown in solid letters to indicate that it is enabled and available for selection.", "Returning to FIG.", "7, when implementing the security feature, the control application determines whether the user changed the current status of the power tool 104 (at block 302) using the current status selector 287.If the control application determines that the current status of the power tool 104 has changed, the control application proceeds to block 303 and forwards the updated security settings (e.g., lock or unlock) to the power tool 104.The control application then proceeds to determine whether the user has changed settings associated with the scheduled lock (at blocks 304-316).", "If the control application determines that the current status of the power tool 104 has not changed in block 302, the control application proceeds to determine whether the user has changed settings associated with the scheduled lock (at blocks 304-316).", "For example, as shown in FIG.", "10C, the current status of the power tool 104 is “unlocked,” as indicated by the current status indicator 286.Therefore, the power tool 104 is operable.", "When the current status of the power tool 104 is “unlocked,” the scheduled lock option 288 is available for user selection.", "In FIG.", "10C, to indicate that the scheduled lock option 288 is available for selection, it is shown in solid letters similar to the current status indicator 286.As shown in FIGS.", "10C and 10D, the scheduled lock option 288 includes a schedule lock on/off selector 292, a future lock-out indication 294, and an edit option 296.The schedule lock on/off selector 292 enables and disables the scheduled lock option 288 accordingly.", "When the scheduled lock is disabled (i.e., the on/off selector 292 is in the OFF position as shown in FIG.", "10C), the power tool 104 operates according to the current status selector 287.When the schedule lock is enabled, however, (i.e., the on/off selector 292 is in the ON position as shown in FIG.", "10D) the control application displays the future lock-out indication 294.The future lock-out indication 294 indicates to the user a current time 298 and an indication 300 of the remaining time before the power tool 104 is under lock-out.", "In some embodiments, instead of the current time 298, the control application displays the defined lock-out time and the remaining time before the power tool 104 becomes inoperable.", "Returning to FIG.", "7, at block 304, the control application determines whether the scheduled lock is enabled (at block 304).", "If the scheduled lock is disabled (e.g., the on/off selector 292 is in the OFF position), the control application waits for additional user input (e.g., pressing of a back or cancel key) and responds accordingly (at block 305).", "For example, the control application may return to a previous block of the method 700 based on the additional user input.", "On the other hand, if the scheduled lock is enabled, the control application determines whether the edit option 296 has been selected (at block 306).", "If the control application determines that the edit option 296 is not selected, the control application proceeds to block 320 and forwards updated settings to the power tool 104.In some instances (e.g., when the user does not change any security settings), the control application bypasses block 320 and proceeds back to block 283.If the control application receives an indication that the user selected the edit option 296, the control application displays a scheduled lock edit screen 308, as shown in FIG.", "11 (at block 312).", "The edit option 296 and the edit screen 308 allow the user to change the specified time before the power tool 104 becomes inoperable due to the security feature.", "As shown in FIG.", "11, the edit screen 308 includes editable lock fields 309a-h. Each editable lock field 309a-h displays a current setting value and can be changed by the user.", "For instance, selecting field 309a causes a drop down calendar to be displayed through which the control application can receive a user's date selection.", "The other lock fields 309b-h are similarly updateable through user selection and/or direct text entry.", "As shown on the edit screen 308, the user specifies a period of time (e.g., three hours or 30 days), and/or an end (e.g., disable) date (e.g., Jun.", "15, 2015), such that when the period of time has expired or the specified end date has passed based on the date/time indicated by the RTC 260, the power tool 104 locks out and becomes disabled (i.e., the power tool 104 is rendered inoperable even if a new battery pack 215 is attached).", "When the user enables the security feature and enters the edit screen 308, the user indicates a period of time or a disable time.", "As shown in FIG.", "11, the user can select whether to edit the “lock-out time” or the “remaining time.” In the illustrated embodiment, when the user changes one of the lock-out time or the remaining time, the other option automatically updates to correspond to the same lock-out time.", "For example, if the user enters a new lock-out time (e.g., Jun.", "15, 2015 at 5:30 P.M.), the control application automatically updates the remaining time.", "In the illustrated embodiment, the current time is Jun.", "13, 2015 1:58 P.M. and, thus, the remaining time shows two days, three hours, and 32 minutes.", "A user can alternatively specify a period of time instead of a specific disable time, by adjusting the remaining time options.", "Being able to change the units of the time period also allows a user to have more flexibility in scheduling.", "The control application then calculates the disable date based on the current date and the user specified period of time.", "In the illustrated example, the user can identify the remaining time to be two days, three hours, and 32 minutes.", "The control application then calculates that the disable time would be Jun.", "15, 2015 at 5:30 P.M., and updates the displayed lock out time in lock fields 309a and 309b accordingly.", "Although the remaining time options in the illustrated embodiment only include days, hours, and minutes, the units for each digit may be changed.", "For example, the user may change the first label from days to weeks.", "In such an instance, the lock-out time would be later than Jun.", "15, 2015.Returning to FIG.", "7, once the user has made the desired changes to the scheduled lock settings, the control application receives and saves the updated settings (at block 316).", "The external device 108 then communicates with the power tool 104 to forward the updated settings for the scheduled lock and/or for the direct lock (at block 320).", "In particular, the external device 108 communicates to the power tool 104 whether the power tool 104 is to change from the lock state to the unlock state, from the unlock state to the lock state, and/or whether a scheduled lock has been established for the power tool 104 along with the scheduled lock settings.", "When the wireless communication controller 250 receives data indicating that the user enabled the security feature and the specified disable date, the wireless communication controller 250 (e.g., the processor 258) forwards the information to the controller 226 as previously described with respect to other tool data.", "The controller 226 updates stored data to indicate that the security feature has been enabled and the indicated current state and the disable date (e.g., lock-out time).", "The controller 226 compares the current day/time from the RTC 260 to the disable data periodically or upon each trigger pull.", "Once the controller 226 determines that the disable date has been reached, the controller 226 ceases to drive the motor 214.The power tool 104 remains enabled when the security feature is disabled.", "Therefore, wireless communication between the power tool 104 and the external device 108 enables tool owners to limit tool usage based on a time.", "In other embodiments, the security features may disable the power tool 104 based on other parameters such as, for example, number of trigger pulls, number of completed tasks, number of power on/off switches, and the like.", "For example, the security control screen 282 includes additional fields to receive user input specifying these other parameters.", "Additionally, in some embodiments, the power tool 104 may shut down permanently when it has not communicated with an external device 108 for a predetermined period of time or after a predetermined number of unsuccessful attempts to communicate with an external device 108.For example, in such embodiments, the external device 108 may provide an acknowledgement message to the power tool 104 to indicate that the external device 108 received a message (e.g., an identification signal, an advertisement message, or the like) from the power tool 104.When the power tool 104 does not receive such an acknowledgement message from the external device 108 after a predetermined period of time or after a predetermined number of unsuccessful attempts, the wireless communication controller 250 may control the power tool 104 to enter the locked state (i.e., disable operation of the motor 214).", "The power tool 104 may remain permanently locked or semi-permanently locked.", "To exit a semi-permanent lock sate, the power tool 104 may need to be returned to an authorized dealer or the manufacturer for unlocking (e.g., via providing to the power tool 104 a particular authorization code recognizable by the controller 226).", "In some embodiments, the power tool 104 exits the semi-permanent lock state upon establishing a communication link with the external device 108.In the illustrated embodiment, the security feature is disabled by default (e.g., from the factory) and is then enabled by the user at a later time.", "When no power source is available (i.e., the battery pack 215 and the backup power source 252 are disconnected from the power tool 104 or are depleted), the RTC 260 cannot keep time.", "Therefore, the RTC time is not incremented and the period of time specified by the user will be extended because the tool 104 will require a longer time period to reach the disable time.", "To operate the power tool 104 again, the battery pack 215 must be connected to the power tool 104.When a charged battery pack 215 is connected to the power tool 104, the RTC 260 increments time again, the disable time is reached, and the power tool 104 is disabled.", "Therefore, even if the backup power source 252 is depleted, the security feature is not disabled.", "Accordingly, the power tool 104 provides a way to manage and limit the use of the power tool 104 and provides a level of tool lock-out and security that can be enabled by the tool owner to decrease or deter theft of power tools.", "The backup power source 252 (e.g., a coin cell battery, another type of battery cell, a capacitor, or another energy storage device) includes an independent assembly within the power tool 104 that includes its own unique printed circuit board (PCB) 323 (see FIGS.", "12A-E).", "The backup power source 252 provides power to the wireless communication controller 250 to enable the wireless communication controller 250 to operate in the advertisement state.", "The backup power source 252 also provides power to the RTC 260 to enable continuous tracking of time.", "The backup power source 252 does not provide power to energize the motor 214, drive the drive device 210, or power the controller 226, and generally only powers the wireless communication controller 250 and the RTC 260 (e.g., in embodiments in which the RTC 260 is separate from the wireless communication controller 250) when the battery pack 215 is not attached to the power tool 104.In other embodiments, the backup power source 252 also provides power to low-power elements such as, for example, LEDs, and the like.", "In some embodiments, the wireless communication controller 250 includes a voltage sensor 265 (see FIG.", "6B) coupled to the backup power source 252.The wireless communication controller 250 uses the voltage sensor 265 to determine the state of charge of the backup power source 252.The wireless communication controller 250 may include the state of charge of the backup power source 252 in the advertisement message to the external device 108.The user can then be alerted when the state of charge of the backup power source 252 is low.", "In other embodiments, the wireless communication controller 250 only includes the state of charge of the backup power source 252 in the advertisement message when the state-of charge is below a low power threshold.", "Accordingly, the user can be alerted to charge or replace the backup power source 252.As shown in FIGS.", "12A-D, the backup power source 252 includes a coin cell battery 324 located on the PCB 323.The coin cell battery 324 is merely exemplary.", "In some embodiments, the backup power source 252 may be another type of battery cell, a capacitor, or another energy storage device.", "The coin cell battery 324 is positioned proximate (e.g., near) the wireless communication controller 250 to minimize wiring within the power tool 104.The coin cell battery 324 provides sufficient power to allow the wireless communication controller 250 to operate in the advertisement state and broadcast minimal identification information.", "In the illustrated embodiment, the coin cell battery 324 can run for several years by allowing the power tool 104 to only “broadcast” or “advertise” once every few seconds when operating the advertisement state.", "In the illustrated embodiment, the coin cell battery 324 is a primary (i.e., non-rechargeable) backup battery.", "In other embodiments, the backup power source 252 includes a secondary (rechargeable) backup battery cell or a capacitor.", "In such embodiments, the battery pack 215 provides charging power to recharge the secondary backup battery cell or the capacitor.", "For example, the power input unit 224 may include charging circuitry to charge the backup power source 252.The rechargeable cell and capacitor may be sized to provide power for several days or weeks before needing to recharge.", "The backup power source 252 is inserted as a separate assembly inside the handle 204 of the power tool 104.As shown in FIGS.", "12A-E, the battery pack receiving portion 206 also includes a coin cell slot 328.The coin cell slot 328 is positioned adjacent the connecting structure that receives the battery pack 215 and is a separate compartment of the tool housing.", "The foot of the power tool 104 (i.e., the battery pack receiving portion 206) defines a foot print perimeter of the power tool 104.The perimeter is defined by the edges A, B, C, D (see FIG.", "5) of the battery pack receiving portion 206.As shown more clearly on FIG.", "5, the coin cell slot 328 is positioned on a lateral side (i.e., side B or D) of the battery pack receiving portion 206.As shown in FIG.", "5 and FIG.", "12E, the backup power source 252 is secured in place by a removable plastic cover 332.The removable plastic cover 332 is attached to the power tool housing by two screws 333.The screws can be removed when replacement of the battery is needed (e.g., when the voltage of the coin cell battery 324 depletes).", "In some embodiments, the coin cell slot 328 is accessible via a sliding or hinged door.", "Although in the illustrated embodiment, the coin cell slot 328 is positioned within the battery pack receiving portion 206, in other embodiments, the coin cell slot 328 is positioned elsewhere on the power tool 104.For example, FIG.", "13 schematically illustrates various other positions E, F, G for the coin cell slot 328.For example, position E shows the coin cell slot 328 being positioned below the selection switch 208 at the foot of the power tool 104.Position F shows the coin cell slot 328 at or near a location where the handle 204 and the foot of the power tool 104 meet.", "Position G shows the coin cell slot 328 in the handle 204, and, in particular, in a bottom portion of the housing of the handle 204.Positioning the coin cell slot 328 in the battery pack receiving portion 206 has several advantages.", "For example, because the coin cell slot 328 is positioned in the battery pack receiving portion 206, the battery pack 215 is removed before the coin cell battery 324 is replaced, thereby ensuring that the power tool 104 is not in operation while the coin cell battery 324 is replaced.", "Additionally, including the coin cell slot 328 in the battery pack receiving portion 206 avoids having the slot 328 straddle the interface of the power tool's right and left clam shell housing portion, which could weaken the structural integrity of the housing.", "Furthermore, by positioning the coin cell slot 328 in the battery pack receiving portion 206, the manufacturing of the housing remains mostly the same.", "In other words, since the position of the coin cell slot 328 is within an already existing portion of the housing, most of the portions manufactured to make the housing can remain the same and a limited number of changes to the housing design have to be made.", "For example, as shown more clearly in FIGS.", "12B-C, both sides of the housing have the same profile.", "By placing the coin cell battery 324 in the battery pack receiving portion 206, the coin cell battery 324 utilizes space not previously utilized, keeping the power tool 104 compact and efficient.", "The position of the coin cell battery 324 also does not interfere with any of the foot accessories of the power tool 104.For example, on the same side of the foot that houses the coin cell slot 328, a belt hook mount 336 is provided having three recesses 338a, 338b, and 338c (FIG.", "12D) for attachment of a belt hook 340 (see FIG.", "13).", "Additionally, a lanyard is attachable to the belt hook mount 336.In the illustrated embodiment, the power tool 104 includes the belt hook mount 336 on both lateral sides, including the lateral side having the coin cell slot 328, yet the coin cell slot 328 does not interfere with the attachment of the belt hook 340.Each of the belt hook mounts 336 is a protrusion from one of the lateral sides of the power tool 104.The belt hook 340 including an attachment end with a throughole 341 and two bosses not shown.", "The throughole 341 aligns with the (threaded) recess 338a, which includes a threaded insert, and the each of the bosses aligns with one of the (alignment) recesses 338b and 338c.", "To secure the belt hook 340 to the belt hook mount 336, a screw is inserted through the throughole 341 and into the threaded recess 338a where the screw is rotated to fasten the belt hook 340.The recesses 338a, 338b, and 338c of the belt hook mount 336 stop short of, and do not extend into the, the coin cell slot 328.In some embodiments, the wireless communication controller 250 resides with the backup power source 252 in the coin cell slot 328.For example, the PCB 323 may include both terminals for receipt of a power source, such as coin cell battery 324, and the wireless communication controller 250.In such embodiments, the communication channel 262 may be in the form of a selectively connectable ribbon cable or other connector that couples the PCB 323 (and the components thereon) with the controller 226.Accordingly, the PCB 323, including the backup power source 252 and the wireless communication controller 250, may be part of a modular unit that is selectively inserted into (or removed from) the power tool 104 to selectively provide wireless communication capabilities for the power tool 104.In such embodiments, the wireless communication controller 250 may be coupled to the power input 224, as shown in FIG.", "6A, through the same ribbon cable that provides the communication channel 262.Accordingly, the wireless communication controller 250 may be powered by a battery pack coupled to the battery pack interface 222, if present, or the backup power source 252.A switch on the PCB 323 may be controlled to select between power sources based on the presence or absence of power available from the power input 224.FIG.", "14 illustrates a method 1400 of general operation of the power tool 104.First, the power tool 104 (e.g., controller 226 or 250) determines whether there is a power source present (at block 342).", "If there is a power source present (e.g., the battery pack 215 is connected to the power tool 104 or the backup power source 252 is available), the RTC 260 increments time (at block 344) and saves the latest RTC time (at block 348) in case the power source becomes disconnected and/or depleted.", "Stated another way, at block 348, the controller 226 obtains the RTC time.", "The controller 226 then determines whether the user is attempting to operate the power tool 104 (at block 352).", "For example, the controller 226 may monitor the trigger switch 213 to determine whether the user is attempting to operate the power tool 104.If the user is not attempting to use the power tool 104, the power tool 104 remains idle and the method 1400 proceeds back to block 342.However, if the user is attempting to utilize the power tool 104, the controller 226 then determines whether the security feature is enabled (at block 356).", "If the security feature is not enabled, the power tool 104 operates normally (at block 360).", "From block 360, the method 1400 may proceed back to block 342 to repeat the method 1400.At block 356, if the security feature is enabled, the controller 226 determines whether the current status of the power tool 104 is set to “unlock” (at block 364).", "If the current status of the power tool 104 is not set to “unlock” (e.g., the status is set to “lock”), the power tool 104 remains idle and the controller 226 disables normal operation of the power tool 104 (at block 368).", "From block 368, the method 1400 may proceed back to block 342 to repeat the method 1400.At block 364, if the current status of the power tool 104 is set to “unlock,” the controller 226 then determines whether the scheduled lock is enabled (at block 372).", "If the scheduled lock is disabled, the power tool 104 operates normally (at block 360).", "If the scheduled lock is enabled, the controller 226 determines whether the current RTC time exceeds the disable time (at block 376).", "If the current RTC time has not exceeded the disable time (i.e., the lock-out time), the power tool 104 operates normally (at block 360).", "On the other hand, if the RTC time meets or exceeds the disable time, the power tool 104 is becomes idle and the controller 226 disables normal operation of the power tool 104 (at block 368).", "The power tool 104 remains disabled until the security feature is disabled or the disable time is updated to a future time on the external device 108.As indicated in FIG.", "14, from both of blocks 360 and 368, the method 1400 may proceed back to block 342 to repeat the method 1400.Repetition of the method 1400 allows the power tool 104 to receive updated security features from the external device 108 that allow the power tool 104 to adjust its security settings and operation settings.", "In some embodiments, blocks 342 and 344 occur independently (i.e., separate from) the method 1400.In some embodiments, the method 1400 further includes a block of obtaining security settings (e.g., in advance of obtaining the RTC time in block 348).", "Obtaining security settings may occur through receipt, by the controller 226, of security settings from the external device 108 as provided in blocks 303 and 320 of FIG.", "7.FIG.", "15 illustrates a method 1500 of wirelessly communicating by a power tool, such as the power tool 104.In block 1505, the wireless communication controller 250 determines whether the battery pack interface 222 is connected to a battery pack, such as the battery pack 104b (FIG.", "1).", "For example, the processor 258 of the wireless communication controller 250 (FIG.", "6B) may monitor an input pin coupled to the power input unit 224 (FIG.", "6A) to determine whether power is being received from the power input unit 224.Returning to FIG.", "15, when the wireless communication controller 250 determines that a battery pack is coupled to the battery pack interface 222, the wireless communication controller enters the connectable state (block 1510).", "In block 1515, the wireless communication controller 250 forms a wireless communication link with the external device 108.As noted above, the wireless communication link may be the Bluetooth® link or another wireless protocol link.", "The communication link may be particularly formed between the processor 258 of the wireless communication controller 250 and the processor 114 of the external device 108 via the antenna and transceiver 254 and the short-range transceiver 118.In block 1520, the wireless communication controller 250 communicates, over the wireless communication link, to one or more of transmit tool operational data and receive tool configuration data from the external device 108.For example, in some instances, the wireless communication controller 250 transmits tool operational data, such as tool usage data, maintenance data, mode information, drive device information, and the like from the power tool 104.Further, in some instances, the wireless communication controller 250 receives tool configuration data, such as operation thresholds (e.g., speed and torque levels), maintenance thresholds, mode configurations, programming for the power tool 104, feature information, and the like.", "After communicating in block 1520, the wireless communication controller 250 returns to block 1505 to determine whether a battery pack is connected to the battery pack interface 222.When the wireless communication controller 250 determines that no battery pack is connected to the battery pack interface 222 (e.g., the previously connected battery pack has been disconnected from the battery pack interface 222), the wireless communication controller 250 proceeds to enter the advertisement state (block 1525).", "In the advertisement state, the wireless communication controller 250 receives power from and is powered by the backup power source 252.In block 1530, the wireless communication controller 250 transmits an advertisement message including a unique tool identifier.", "For example, the wireless communication controller 250 may periodically broadcast identification information when in the advertisement state.", "In some embodiments, the wireless communication controller 250 may respond to requests (e.g., pings) for identification information.", "In some embodiments, the advertisement message includes additional information, such as a charge level of the backup power source 252.In some embodiments, the method 1500 further includes detecting activation of an actuator, such as by the controller 226 detecting depression of the trigger 212.In response, in the connectable state, the controller 226 controls the switching network 216 to apply power from the battery pack coupled to the battery pack interface 222 to drive the motor 214 based on the actuator activation.", "In some embodiments, the method 1500 further includes the controller 226 obtaining tool usage data from one or more of the sensors 218 while in the connectable state.", "Further, the wireless communication controller 250 receives the tool usage data from a memory of the power tool (e.g., over the communication channel 262).", "The wireless communication controller 250 transmits the tool usage data to the external device as part of the tool operational data.", "In some embodiments, the method 1500 further includes the controller 226, while in the connectable state, storing tool configuration data received from the external device 108 to the memory 232 (e.g., over the communication channel 262).", "Further, the controller 226 controlling drives the motor 214 of the power tool based on the tool configuration data.", "For example, the controller 226 may drive the motor 214 at a speed specified in the tool configuration data, or until a torque level specified in the configuration data is reached.", "In some embodiments, the controller 226 drives the motor 214 when the wireless communication controller 250 is in the connectable state; but the controller 226 is maintained unpowered when the wireless communication controller 250 is in the advertisement state.", "For example, as noted, in the advertisement state, the battery pack interface 222 is not connected to a battery pack.", "Accordingly, the controller 226 does not receive power from the battery pack interface 222 or power input unit 224.Further, the backup power source 252 is not coupled to the controller 226 and does not provide power to the controller 226 in the advertisement state.", "Accordingly, the controller 226 remains unpowered when the wireless communication controller 250 is in the advertisement state.", "In some embodiments, the method 1500 further includes the coin cell slot 328 (a backup battery receptacle of the power tool) receiving the backup power source 252.Further, a battery pack, when connected to the battery pack interface 222, blocks the coin cell slot 328 and, when disconnected, provides access to the coin cell slot 328.For example, as shown in FIG.", "5, the coin cell slot 328 is located in the battery pack receiving portion 206.When a battery pack (e.g., the battery pack 104b) is coupled to the battery pack receiving portion 206 (and, thereby, the battery pack interface 222), the coin cell slot 328 is inaccessible.", "However, when the battery pack is disconnected from the battery pack receiving portion 206, the coin cell slot 328 is again In some embodiments, the method 1500 further includes powering the wireless communication controller 250 with power from the backup power source 252 in the advertisement state; and powering the wireless communication controller with power from the backup pack in the connectable state.", "In some embodiments, the method 1500, or a method of displaying a communication state of a power tool, includes receiving, by the external device 108, data transmitted by the wireless communication controller 250.The received data may that which is transmitted in block 1520 and block 1530 (e.g., one or more of unique tool identifier, an advertisement message, and operational data).", "The external device 108 determines a communication state of the wireless communication controller.", "For example, the external device 108 determines whether the wireless communication controller 250 is in the advertisement state or the connectable state.", "The determination may be made based on, for example, a format of the data received from the wireless communication controller 250 or based on state information explicitly included within the data received.", "Upon determining the state of the wireless communication controller 250, the external device 108 displays an indication of the determined state along with an identity of the power tool, which also may be determined based on the received data (e.g., based on a received unique tool identifier).", "For example, with reference to FIG.", "8, the external device 108 may display an indication of the tool identity based on the received data (e.g., based on a unique tool identifier) along with a wireless symbol in a first style that is grayed out or lighter when in the advertisement state and in a second style that is darker or bolder when in the connectable state.", "Although the flow charts of FIGS.", "7, 14, and 15 are illustrated and described as blocks performed in a serial manner, one or more blocks of the methods 700, 1400, and 1500 may be executed in parallel or in a different order than described.", "In some embodiments, the wireless communication controller 250 remains in the connectable state even after removal of a battery pack from the battery pack interface 222.For example, the backup power source 252 may power the wireless communication controller 250 and the controller 226, enabling both retrieval of tool operational data from the memory 232 for export to the external device 108 and updating of tool configuration data residing in the memory 232 based on data received from the external device 108.When the wireless communication controller 250 is in a connectable state and is powered by the backup power source 252, and a battery pack is not coupled to the battery pack interface 222, the power tool 104 may be referred to as being in a low-power connectable state.", "In the low-power connectable state, the power tool 104 is operable to communicate with the external device 104, as is usual in the connectable state, but the motor 214 is in a non-drivable state because the power source for the motor 214 has been removed (i.e., insufficient power is available for supply to the switching network 216).", "The low-power connectable state may also be referred to as a non-driving connectable state, as the motor 214 is not driven, yet full communication capabilities are present (i.e., the communications are not limited or restricted as in the advertisement state).", "In these embodiments, when a battery pack is coupled to the battery pack interface 222, the power tool 104 enters the previously described, full-power connectable state, such as described with respect to blocks 1510, 1515, and 1520 in FIG.", "15.This connectable state may also referred to as a driving connectable state because the motor 214 may be driven and full communication capabilities are present.", "Thus, the invention provides, among other things, a power tool that can identify itself to an external device even when a battery pack is not attached to the power tool, and a power tool that can enable a time-based security feature.", "Various features and advantages of the invention are set forth in the following claims." ] ]
Patent_15874185
[ [ "POWER TOOL ELECTRONICS", "A battery waking circuit and a battery leakage circuit are provided.", "The battery waking circuit includes a first battery pack and a second battery pack connected in series and a first switch connected to the first battery pack along a first current path.", "An electronic controller coupled to and controlling the first switch is configured to close the first switch based on detecting a trigger actuation to draw a wake-up current on the first current path from the first battery pack.", "The electronic controller is also configured to control a motor to draw a load current along a second current path after the first battery pack is woken up.", "The battery leakage circuit also includes a switch connected in series with the capacitor and a trigger switch controlling the switch such that the switch prevents a flow of leakage current through the capacitor when the trigger is not actuated." ], [ "1.A method of preventing leakage current in a power tool, the method comprising: controlling, by a trigger, a leakage switch to close based on actuation of the trigger; permitting a flow of leakage current through a capacitor based on closing the leakage switch, the capacitor coupled to a power supply of the power tool; controlling, by the trigger, the leakage switch to open based on de-actuation of the trigger; preventing the flow of leakage current through the capacitor and the leakage switch based on opening the leakage switch; and controlling, via an electronic controller, a switch bridge to selectively supply power to stator coils of a motor of the power tool to drive the motor using load current from the power supply.", "2.The method of claim 1, further comprising: closing a trigger switch based on actuation of the trigger; and opening the trigger switch based on de-actuation of the trigger, wherein the trigger switch controls the leakage switch to open and close.", "3.The method of claim 2, wherein controlling the leakage switch to close based on the closing of the trigger switch includes coupling a control input of the leakage switch to a battery pack of the power supply via the trigger switch, wherein the trigger switch is positioned along a control path between the battery pack and the control input of the leakage switch.", "4.The method of claim 1, wherein the power tool includes a motor control circuit, which further includes the switch bridge and a motor electronic processor of the electronic controller.", "5.The method of claim 1, wherein the power tool includes a circuit board assembly, which further includes a handle circuit board and a motor control board.", "6.The method of claim 5, wherein the handle circuit board includes a handle electronic processor, a wakeup circuit, and a trigger assembly, and the motor control board includes a motor electronic processor, the leakage switch, and the switch bridge, and wherein the electronic controller includes the handle electronic processor and the motor electronic processor.", "7.The method of claim 1, wherein the power tool is one selected from the group of a miter saw, a drill/driver, a hammer drill/driver, an impact drill driver, a circular saw, a reciprocating saw, and a table saw.", "8.The method of claim 1, wherein the power tool include a first battery pack and a second battery pack coupled in series.", "9.A power tool comprising: a power supply having a positive terminal and a negative terminal; a capacitor coupled across the positive terminal and the negative terminal of the power supply; a leakage switch connected between the capacitor and the negative terminal; a motor coupled across the capacitor and the leakage switch; and a trigger controlling the leakage switch such that the leakage switch permits a flow of leakage current through the capacitor when the trigger is actuated and prevents the flow of leakage current through the capacitor when the trigger is de-actuated.", "10.The power tool of claim 9, further comprising a trigger switch coupled to the leakage switch, wherein the trigger switch is closed when the trigger is actuated and opened when the trigger is de-actuated.", "11.The power tool of claim 10, wherein the power tool includes a first battery pack and a second battery pack coupled in series, and the trigger switch is coupled to a negative terminal of the first battery pack and a positive terminal of the second battery pack.", "12.The power tool of claim 9, wherein the power tool includes a switch bridge and an electronic controller, the electronic controller configured to: control the switch bridge to selectively supply power to stator coils of a motor of the power tool to drive the motor using load current from the power supply.", "13.The power tool of claim 9, wherein a motor control circuit includes a switch bridge and a motor electronic processor of the electronic controller.", "14.The power tool of claim 9, wherein the power tool includes a circuit board assembly, which further includes a handle circuit board and a motor control board.", "15.The power tool of claim 14, wherein the handle circuit board includes a handle electronic processor, a battery wakeup circuit, and a trigger assembly including the trigger, and the motor control board includes a motor electronic processor, the leakage switch, and a switch bridge.", "16.The method of claim 9, wherein the power tool is one selected from the group of a miter saw, a drill/driver, a hammer drill/driver, an impact drill driver, a circular saw, a reciprocating saw, and a table saw." ], [ "<SOH> FIELD OF THE INVENTION <EOH>This application relates to electronics of power tools.", "More specifically, the application relates to battery leakage circuits and battery waking circuits of power tools." ], [ "<SOH> BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS <EOH>FIG.", "1 is a perspective view of a miter saw in accordance with some embodiments.", "FIG.", "2 is a block diagram of the miter saw of FIG.", "1 in accordance with some embodiments.", "FIG.", "3 is a circuit diagram of a battery pack that may be used with the miter saw of FIG.", "1 in accordance with some embodiments.", "FIG.", "4 is a circuit diagram of a battery waking circuit in accordance with some embodiments.", "FIG.", "5 is a circuit diagram of a battery waking circuit in accordance with some embodiments.", "FIG.", "6 is a flowchart of a method of waking up a power tool power source in accordance with some embodiments.", "FIG.", "7 is a circuit diagram of a battery leakage circuit in accordance with some embodiments.", "FIG.", "8 is a flowchart of a method of preventing leakage current in a power tool in accordance with some embodiments.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "RELATED APPLICATIONS This application is a continuation of and claims priority benefit to U.S. Non-Provisional application Ser.", "No.", "15/223,400, filed Jul.", "29, 2016, the entire contents of which are hereby incorporated by reference.", "FIELD OF THE INVENTION This application relates to electronics of power tools.", "More specifically, the application relates to battery leakage circuits and battery waking circuits of power tools.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS FIG.", "1 is a perspective view of a miter saw in accordance with some embodiments.", "FIG.", "2 is a block diagram of the miter saw of FIG.", "1 in accordance with some embodiments.", "FIG.", "3 is a circuit diagram of a battery pack that may be used with the miter saw of FIG.", "1 in accordance with some embodiments.", "FIG.", "4 is a circuit diagram of a battery waking circuit in accordance with some embodiments.", "FIG.", "5 is a circuit diagram of a battery waking circuit in accordance with some embodiments.", "FIG.", "6 is a flowchart of a method of waking up a power tool power source in accordance with some embodiments.", "FIG.", "7 is a circuit diagram of a battery leakage circuit in accordance with some embodiments.", "FIG.", "8 is a flowchart of a method of preventing leakage current in a power tool in accordance with some embodiments.", "DETAILED DESCRIPTION OF THE INVENTION Before any embodiments of the invention are explained in detail, it is to be understood that the invention is not limited in its application to the details of construction and the arrangement of components set forth in the following description or illustrated in the following drawings.", "The invention is capable of other embodiments and of being practiced or of being carried out in various ways.", "One embodiment discloses a method of waking up a power tool power source including a first battery pack and a second battery pack.", "The method includes detecting, using an electronic controller, a trigger actuation and controlling, using the electronic controller, a first switch to close based on detecting the trigger actuation.", "The method also includes drawing a wake-up current from the first battery pack upon closing the first switch and controlling a motor to draw a load current after the first battery pack is woken-up by the wake-up current.", "Another embodiment provides a power tool including a first battery pack and a second battery pack connected in series, a first switch connected to the first battery pack along a first current path, and an electronic controller coupled to and controlling the first switch.", "The electronic controller is configured to detect a trigger actuation and close the first switch based on detecting the trigger actuation to draw a wake-up current on the first current path from the first battery pack.", "The electronic controller is also configured to control the motor to draw a load current after the first battery pack is woken up.", "Another embodiment provides a method of preventing leakage current in a power tool.", "The method includes controlling, by a trigger, a leakage switch to close based on actuation the trigger and permitting a flow of leakage current through a capacitor based on closing the leakage switch, the capacitor coupled to a power supply of the power tool.", "The method also includes controlling, by the trigger, the leakage switch to open based on de-actuation of the trigger and preventing the flow of leakage current through the capacitor and the leakage switch based on opening the leakage switch.", "Another embodiment provides a power tool including a power supply having a positive terminal and a negative terminal and a capacitor coupled across the positive terminal and the negative terminal of the power supply.", "The power tool also includes a leakage switch connected between the capacitor and the negative terminal and a motor coupled across the capacitor and the leakage switch.", "The power tool further includes a trigger controlling the leakage switch such that the leakage switch permits a flow of leakage current through the capacitor when the trigger is actuated and prevents the flow of leakage current through the capacitor when the trigger is de-actuated.", "FIG.", "1 illustrates a miter saw 100 operable to perform cuts (for example, a miter cut or a bevel cut) on a work piece (for example, lumber).", "In the illustrated example, the miter saw includes a turntable 110 that rotates relative to a base 120.The base 120 and the turntable define a support surface for the work piece to be cut.", "A saw unit 130 is coupled to the turntable 110 for movement with the turntable 110 and includes a saw arm 132 and a saw blade 134.A power supply unit 140 including a first battery pack 142 and a second battery pack 144 powers a motor of the saw unit 130 to rotate the saw blade 134.The saw arm 132 includes a trigger 150 that, when actuated, operates the saw unit 130.The saw arm 132 further includes a housing 152 in which various electronics of the miter saw 100 reside and on which are battery receptacles to receive the first battery pack 142 and the second battery pack 144.FIG.", "2 is a block diagram of the miter saw 100 of FIG.", "1.The miter saw 100 includes the power supply 140, a handle circuit board 210, a motor control board 220, a motor 230, and an output unit 240 (for example, the saw blade 134).", "The power supply 140 provides power for operation of the miter saw 100.The power supply 140 includes the first battery pack 142 and the second battery pack 144.The handle circuit board 210 is located in the saw arm 132 and includes a trigger assembly 212 that is coupled to the trigger 150.Accordingly, the handle circuit board 210 is connected to the trigger 150 that is used to operate the miter saw 100.When a user actuates the trigger 150, generally, the handle circuit board 210 connects the power supply 140 to the electronics of the miter saw 100.The handle circuit board 210 includes a handle electronic processor 214 to control the operations of the handle electronics.", "Handle electronics may include a laser or light emitting diodes (LEDs) to be turned on during the operation of the miter saw to illuminate a work piece, illuminate a cutline on the work piece, or both.", "The handle circuit board 210 also includes a battery waking circuit 250 to wake-up the first battery pack 142 before the operation of the motor 230 of the miter saw 100.The trigger assembly 212, the handle electronic processor 214, and the battery waking circuit 250 communicate over one or more control and/or data buses (for example, a communication bus 215).", "The handle circuit board 210 is connected via a line 216 (e.g., a conductive wire) to the positive terminal of the second battery pack 144 and to the negative terminal of the first battery pack 142.The handle circuit board receives operating power over the line 216.The motor control board 220 includes a motor electronic processor 222 and a switch bridge 224 to control an operation of the motor 230.The motor control board 220 also includes a battery leakage circuit 260 to prevent leakage current from the power supply 140 during a non-operating state of the miter saw 100.The motor electronic processor 222, the switch bridge 224 and the battery leakage circuit communicate over one or more control and/or data buses (for example, a communication bus 225).", "The motor control board 220 is connected to the positive terminal of the first battery pack 142 and the negative terminal of the second battery pack 144 over lines 226 and 227, respectively.", "The motor control board 220 receives load current for operation of the motor 230 over the lines 226 and 227.The motor control board 220 provides load current for operation of the motor 230 through the switch bridge 224.The motor electronic processor 222 provides control signals to the switch bridge 224 to selectively supply power to stator coils of the motor 230 to operate the motor 230.The handle circuit board 210 and the motor control board 220 are connected by four lines 217, 218, 228, and 229.The handle circuit board 210 provides operating power for the electronics of the motor control board 220 over the line 217.That is, the handle circuit board 210 provides the power received from the second battery pack 144 over the line 216 to the motor control board 220 over the line 217.The handle circuit board 210 provides information regarding trigger actuation over the line 218.For example, the handle circuit board 210 may send a high signal when the trigger 150 is actuated and a low signal when the trigger 150 is de-actuated.", "The motor electronic processor 222 uses the signal received over the line 218 to control the switch bridge 224.The motor control board 220 provides positive power supply from the positive terminal of the first battery pack 142 over the line 228 and the negative supply or ground from the negative terminal of the second battery pack 144 over the line 229.That is, the motor control board 220 provides the power received from the power supply 140 over the lines 226 and 227 to the handle circuit board 210 over the lines 228 and 229.For example, the motor controller 220 includes a positive supply node connecting the line 226 and the line 228, and a negative supply node connecting the line 227 and the line 229.In some embodiments, each of the handle controller board 210 and the motor control board 220 may be directly coupled to the power supply 140 via each of the lines 216, 226, and 227, rather than having indirect connections via the other of the motor control board 220 or hall control board 210.The handle circuit board 210, the motor control board 220, and the motor 230 are located within the housing 152 (see FIG.", "1) FIG.", "3 shows a circuit diagram of an example battery pack 300.In some embodiments, the battery pack 300 is implemented as the first battery pack 142 and the second battery pack 144.In the example illustrated, the battery pack includes five cells CL1 to CL5.In some embodiments, the cells have a lithium-ion based chemistry and each provide approximately 3.6 Volts nominal voltage.", "In other embodiments, the cells have different chemistry, voltage output, or both.", "In some embodiments, ten, fifteen or another number of cells are provided in the battery pack 300.The cells CL1 to CL5 are connected in series with each other.", "Positive terminal of the cell CL5 is connected to battery electronics (for example, the by-pass diode 340 and the battery controller 350).", "Negative terminal of cell CL1 is connected in series with a current sense resistor 310, a discharge MOSFET 320, and charge MOSFET 330.A bypass diode 340 is connected across the cells CL1 to CL5, the current sense resistor 310, the discharge MOSFET 320, and the charge MOSFET 330.The battery pack 300 also includes a battery controller 350 to control the battery electronics and a battery wake-up circuit 360.The battery controller 350 is connected to the positive terminal of each cell CL1 to CL5 to monitor the voltage for each cell CL1 to CL5.The battery controller 350 is also coupled to and receives an input from the battery wake-up circuit 360.The battery controller 350 is also coupled to and provides an output to each of the discharge MOSFET 320, the charge MOSFET 330, and the battery wake-up circuit 360.The battery wake-up circuit 360 alerts the battery controller 350 of a charge, discharge, or idle state of the battery pack 330 in order for the battery controller 350 to activate or deactivate the appropriate MOSFET.", "An input of the battery wake-up circuit 360 is coupled to the drain of the discharge MOSFET 320 and the drain of the charge MOSFET 330.An output of the battery wake-up circuit 360 is connected to an input of the battery controller 350 as described above.", "When the battery wake-up circuit 360 detects that the battery pack 300 is connected to a power tool (for example, the miter saw 100), the battery wake-up circuit 360 provides an output indicating the connection to the battery controller 350.In some embodiments, instead of detecting and alerting a connection to a power tool, the battery wake-up circuit 360 may detect and alert a trigger actuation of the power tool.", "The battery wake-up circuit 360 detects that the battery pack 300 is connected to a power tool or that a trigger is actuated when the battery wake-up circuit 360 receives a current on the drain line connecting the drains of the MOSFETS 320, 300 to the battery wake-up circuit 360.The battery controller 350, upon receiving the input signal indicating a connection to a power tool or a trigger pull, closes the discharge MOSFET 320 to allow the battery pack 300 to provide power to the power tool (for example, the miter saw 100).", "Similarly, when the battery wake-up circuit 360 detects a charger, the battery wake-up circuit 360 alerts the battery controller 350 and the battery controller 350 closes the charger MOSFET 330.Returning to FIG.", "2, during operation, when the trigger 150 is actuated, the handle circuit board 210 draws small amount of current from the second battery pack 144 over the line 216 for the operation of the handle circuit board 210 electronics (for example, to power an LED).", "In the second battery pack 144, the current initially flows through the by-pass diode 340 (of the second battery pack 144) until the battery controller 350 turns on the discharge MOSFET 320, thereby, waking up the second battery pack 144.However, because no such initial current flows through the first battery pack 142, the first battery pack 142 remains idle.", "The battery waking circuit 250 draws small amounts of waking current (as opposed to load current) from the first battery pack 142 to wake-up the electronics of the first battery pack 142 before the operation of the motor 230.If the first battery pack 142 was idle and the second battery pack 144 was awake when operation of the motor 230 began, the first battery pack 142 may be subjected to the load current for the operation of the motor 230 before the battery controller 350 (of the first battery pack 142) turns on the discharge MOSFET 320.This load current before the discharge MOSFET 320 is turned on may result in failure of the by-pass diode 340, and thereby, failure of the first battery pack 142.FIG.", "4 shows a circuit diagram 400 of the power tool 100 with an example of the battery waking circuit 260 in further detail.", "In the example illustrated, the battery waking circuit 260 is connected across the first battery pack 142 of the power supply 140.The power tool 100 includes a first positive terminal 402 and a first negative terminal 404 to connect to a positive and negative terminal respectively of the first battery pack 142.The power supply 140 also includes the second battery pack 144.The power tool 100 also includes a second positive terminal 406 and a second negative terminal 408 to connect to a positive and negative terminal, respectively, of the second battery pack 144.The first negative terminal 404 is connected to the second positive terminal 406.The first positive terminal 402 is connected to the motor control board 220 over the line 226 and the second negative terminal 408 is connected to the motor control board 220 over the line 227.The power supply 140 is connected to the motor control board 220 to provide power for operation of the motor 230, as described above.", "The battery waking circuit 250 includes a switching element 410 connected to the positive power supply through a first resistor R1 over the line 228.In other words, the line 228 is coupled to the first positive terminal 402 via the motor control board 220 and the line 226.The switching element 410 is connected to the first negative terminal 404 and the second positive terminal 406 over the line 216 through a second resistor R2.The switching element 410 receives control signals from the handle electronic processor 214 over the line 420.The switching element 410 may include a relay, a NPN bi-polar junction transistor, a junction field effect transistor (JFET), a metal-oxide-semiconductor field effect transistor (MOSFET), an optocoupler, a TRIAC, a silicon-controlled rectifier (SCR), and the like or a combination thereof.", "In one example embodiment, the switching element 410 is an optocoupler or a relay.", "During operation, the handle electronic processor 214 detects an actuation of the trigger 150 with the trigger assembly 212 (see FIG.", "2).", "Upon detecting the actuation of the trigger 150, the handle electronic processor 214 turns the switching element ON by providing a control signal over the line 420.The switching element 420 draws small amounts of current (for example, waking current) from the first battery pack 142.Once the first battery pack 142 is woken-up with the discharge MOSFET 320 of the first battery pack turned on, the handle electronic processor 214 turns the switching element 410 OFF by providing a control signal over the line 420.FIG.", "5 illustrates the circuit diagram 400 having a particular example embodiment of the switching element 410.In the example illustrated, the switching element 410 includes a first switch 510, a second switch 520, and resistors R3 and R4.The first switch 510 is connected to the first positive terminal 402 through the first resistor R1, the line 228, the motor control board 220, and the line 226.The first switch 510 is connected to the first negative terminal 404 through a second resistor R2.The first switch 510 is controlled by a second switch 520.In the example illustrated, the first switch 510 is a PNP bi-polar junction transistor (BJT).", "The emitter of the first switch 510 is connected to the first positive terminal 402 through the first resistor R1 over the line 228.The collector of the first switch 410 is connected to the first negative terminal 404 through the second resistor R2 over the line 216.The base of the first switch is connected to the second switch 520.In other embodiments, the first switch 410 may be a relay, a NPN bi-polar junction transistor, a junction field effect transistor (JFET), a metal-oxide-semiconductor field effect transistor (MOSFET), an optocoupler, a TRIAC, a silicon-controlled rectifier (SCR), and the like.", "The second switch 520 is connected to the base of the first switch 510 through a third resistor R3.The second switch 520 is connected to the first positive terminal 402 through a fourth resistor R4 and the first resistor R1.The second switch 520 is controlled by the handle electronic processor 214 via the line 420.In the example illustrated, the second switch 520 is an N-channel field effect transistor (FET).", "The drain of the second switch 520 is connected to the base of the first switch 510 through the third resistor R3 and to the first positive terminal 402 through the fourth resistor R4 and the first resistor R1.The source of the second switch 520 is connected to ground and the gate of the second switch 520 is connected to the handle electronic processor 214.In other embodiments, the second switch 520 may be a relay, a bi-polar junction transistor, a metal-oxide-semiconductor field effect transistor, an optocoupler, a TRIAC, a silicon-controlled rectifier (SCR), and the like.", "In some embodiments, the resistor R1 of FIGS.", "4 and 5 is coupled directly to the first positive terminal 402 via line 226, rather than indirectly via the motor control board 220.Similarly, in some embodiments, the switching element 410 of FIGS.", "4 and 5 is coupled directly to the second negative terminal 408, rather than indirectly via the motor control board 220.Further, the trigger assembly 212 of the handle circuit board 210 (see FIG.", "2) is not shown in FIGS.", "4 and 5 to simplify the illustration.", "FIG.", "6 is a flowchart illustrating one example method 600 of waking up a power tool power source.", "As illustrated in FIG.", "6, the method 600 includes a handle electronic processor 214 detecting that the trigger 150 is actuated (at step 610).", "For example, as described above, in response to actuation of the trigger 150, the trigger assembly 212 provides a trigger signal to the handle electronic processor 214.When the handle electronic processor 214 detects that the trigger 150 is actuated, the handle electronic processor 214 provides a signal to close the second switch 520 (at step 620).", "The second switch 520, when closed, provides a path to ground to the first battery pack 142 via the resistors R1 and R4, which draws a current from the first battery pack 142.Additionally, when the second switch 520 is closed, the second switch 430 also draws a current from the base of the first switch 510, thereby closing the first switch 510 (at step 630).", "As such, the battery waking circuit 250 draws a small amount of current (i.e., a wake-up current) to wake up the electronics within the first battery pack 142 (at step 640).", "The wake-up current initially flows through a first path including the first positive terminal 402, the first resistor R1, the fourth resistor R4, and the second switch 520 to ground.", "When the first switch 510 is closed, the wake-up current flows through the first path which now also includes the first switch 510 and the second resistor R2 to the first negative terminal 404.The wake-up current also flows through the resistor R3 to keep the first switch 510 closed.", "Upon drawing wake-up current from the first battery pack 142, as described above with respect to FIG.", "3, the battery wake-up circuit 360 of the first battery pack 142 provides an input to the battery controller 350 to close the discharge MOSFET 320.The battery controller 350 closes the discharge MOSFET 320 to exit the idle state and to allow a load current to flow to the miter saw 100.The load current flows through a second path including the motor control board 220 to the second negative terminal 408.As illustrated, the first current path for the wake-up current does not include motor control board 220, while the second current path (that is, for the load current) includes the motor control board 220 and the motor 230.Thereafter, the motor control board 220 controls the switch bridge 224 to drive the motor 230 (at step 650).", "In some embodiments, the motor control board 220 delays driving the switch bridge 224 for a predetermined amount of time after closing the second switch 520 to ensure that the first battery pack 142 is awake before power is supplied to the motor 230.Drawing current by the motor 230 before the battery packs 142, 144 are awake can cause excess current to be drawn by certain electronics of the battery pack 142, 144, such as by the by-pass diode 340.The wake-up current may be selected to be significantly less than the load current.", "The wake-up current may be selected to be in a range of values that is less than an amount of current that could cause damage to components of the battery pack, when the battery pack is not awake (i.e., in the idle state).", "For example, the wake-up current level may be selected, through the selection of the resistors R1 through R4, to prevent damage to the by-pass diode 340.For instance, the by-pass diode 340 may have a maximum current rating, and the wake-up current level is selected to be below that rating.", "In some embodiments, the wake-up current may be 9 milli-Amperes.", "In other embodiments, the wake-up current is in the range of 5 to 15 milli-Amperes, between 15 and 30 milli-Amperes, or another value less than an average level load current drawn from the power source during an operation of the power tool 100.After the first battery pack 142 is woken up, the handle electronic processor 214 opens the second switch 520 to open the battery waking circuit 250 and stop drawing the wake-up current.", "In some embodiments, the battery waking circuit 250 may be closed for a predetermined amount of time.", "For example, the battery waking circuit 250 may be closed for 10 milliseconds (ms) or more, for 100 milliseconds or more, for 1 second or more, or the like.", "In other embodiments, the battery waking circuit 250 may be opened when the trigger 150 is released.", "In yet other embodiments, the battery waking circuit 250 may be opened when the handle electronic processor 214 determines that the first battery pack 142 is awake or when the handle electronic processor 214 determines that the motor 230 has started.", "In some embodiments, steps 620 and 630 may be referred to as a step of controlling the switching element 410 to close.", "As noted above, the switching element 410 may take various forms, such as the form illustrated in FIG.", "5 or a form including an optocoupler, relay, or other switching device or combination.", "FIG.", "7 shows a circuit diagram 700 of the power tool 100 with an example of the battery leakage circuit 260.In the example illustrated, the battery leakage circuit 260 is connected across the first battery pack 142 and the second battery pack 144.The first positive terminal 402 is connected to positive terminals of three capacitors C1, C2, and C3.The capacitors C1, C2, and C3 may be, for example, electrolytic capacitors that provide a smoothing function to the power supplied to the switch bridge 224.While three capacitors C1, C2, and C3 are illustrated, in some embodiments, one, two, or another number of capacitors are used.", "The battery leakage circuit is connected to the negative terminals of the capacitors C1, C2, and C3.The switch bridge 224 is connected to the capacitors to receive operating power from the lines 226 and 227.The switch bridge 224 provides the operating power to the motor 230.A trigger switch 710 of the trigger assembly 212 (see FIG.", "2) is connected between the line 216 that receives operating power from the second battery pack 144 and the line 217 that provides operating power to the motor control board 220.The trigger 150 and the trigger switch 710 may form an electro-mechanical switch such that, when the trigger 150 is pressed, the trigger switch 710 is closed.", "The handle electronic processor 214 and the motor electronic processor 222 (see FIG.", "2) are not illustrated in FIGS.", "4 and 5 to simplify the illustration.", "The battery leakage circuit 260 includes a leakage switch 720.The leakage switch 720 is connected between the negative terminal of the capacitors C1, C2, and C3 and the second negative terminal 408 via line 227.The leakage switch 720 is controlled by the trigger switch 710.In the example illustrated, the leakage switch 720 is an N-channel field effect transistor.", "The drain of the leakage switch 720 is connected to the negative terminals of the capacitors C1, C2, and C3.The source of the leakage switch 720 is connected to the second negative terminal 408.The gate of the leakage switch 720 is connected to an output terminal of the trigger switch 710 through a fifth resistor R5.Gate and source of the third switch 720 are connected by a sixth resistor R6.The capacitors C1, C2, and C3 may have leakage currents (for example, about 50 micro Amperes).", "The battery packs 142 and 144 will remain awake when a certain amount (for example, about 2 micro Amperes) of current is being drawn from the battery packs 142 and 144 (see above discussion of the wake-up circuit 260 of FIG.", "3).", "Accordingly, if the leakage circuit is allowed to flow from the capacitors C1, C2, and C3, the battery packs 142, 144 may remain awake and drain power, rather than reverting back to the idle state when the trigger 150 is released.", "The leakage switch 620, is controlled to create an open circuit between the capacitors C1, C2, and C3 and the battery packs 142 and 144 to prevent the battery packs 142 and 144 from leaking current during idle modes and enabling the battery packs 142 and 144 to enter the idle state (that is, where the discharge MOSFETs 320 of the battery packs are turned OFF).", "FIG.", "8 is a flowchart of an example method 800 of preventing leakage current through a power tool.", "As illustrated in FIG.", "8, the method 800 includes controlling the leakage switch 720 to close based on actuation of the trigger 150 (at step 810).", "In some embodiments, when the trigger 150 is actuated, the trigger 150 closes the trigger switch 710.As such, a voltage difference is applied between the gate and source of the leakage switch 720, thereby, closing the leakage switch 720.In other embodiments, the motor electronic processor 222 or the handle electronic processor 214 may close the leakage switch 720 upon detecting that the trigger 150 is actuated.", "When the leakage switch 720 is closed, current flows normally to the capacitors C1, C2, and C3, and load current is provided to the switch bridge 224 to drive the motor 230.Further, because the leakage switch 720 is closed a flow of leakage current is permitted to flow through the capacitors C1, C2, and C3 (at step 820).", "The method 800 also includes controlling the leakage switch 720 to open based on de-actuation of the trigger 150 (at step 830).", "In some embodiments, when the trigger 150 is de-actuated, that is, when the trigger 150 is released, the trigger switch 710 controlled by the trigger 150 is opened.", "As such, the gate and source of the leakage switch 720 are at the same voltage, thereby, opening the leakage switch 720.In other embodiments, the motor electronic processor 222 or the handle electronic processor 214 may open the leakage switch 720 upon detecting that the trigger 150 is de-actuated.", "When the leakage switch 720 is open, the leakage switch 720 creates an open circuit between the battery packs and the capacitors C1, C2, and C3.As such, the leakage switch 720 prevents the flow of leakage current through the capacitors C1, C2, and C3 (at step 840).", "Accordingly, the battery packs 142, 144 return to an idle state and control the discharging MOSFET 320 (of the respective battery packs) to open.", "In the above description, several switches such as bi-polar junction transistors, field effect transistors, relays and the like are described as being closed and opened.", "When a switch is closed, the switch enables a current flow through the switch.", "That is, the switch is turned on or enabled.", "Similarly, when the switch is opened, the switch prevents a current flow through the switch.", "That is, the switch is turned off or disabled.", "In the foregoing specification, embodiments of the waking circuit and the leakage circuit are described with respect to a miter saw as a way of an example.", "However, the waking circuit and the leakage circuit may be implemented in other power tools such as a drill/driver, hammer drill/driver, an impact drill driver, a circular saw, a reciprocating saw, a table saw, and the like.", "The various power tools, including the miter saw, may include one, two, or more battery packs 300.The handle electronic processor 214 and the motor electronic processor 222 may be implemented as microprocessors with separate memory.", "In other embodiments, the handle electronic processor 214 and the motor electronic processor 222 may be implemented as a microcontroller (with memory on the same chip).", "The handle electronic processor 214 and the motor electronic processor 222 may be implemented partially or entirely as, for example, a field-programmable gate array (FPGA), an application specific integrated circuit (ASIC), and the like.", "The handle electronic processor 214 and the motor electronic processor 222 may be referred to collectively as an electronic controller.", "In some embodiments, the electronic controller includes the handle electronic processor 214 and the motor electronic processor 222 combined into a single processor residing on one of the handle control board 210 and the motor control board 220.In other embodiments, as illustrated in FIG.", "2, the electronic controller includes the handle electronic processor 214 and the motor electronic processor 222 as separate processors.", "Thus, the invention provides, among other things, a battery waking circuit and a battery leakage circuit for a power tool.", "Various features and advantages of the invention re set forth in the following claims." ] ]
Patent_15874188
[ [ "AUTONOMOUS MOBILE PICKING", "An order-picking method includes autonomously routing a plurality of mobile robotic units in an order fulfillment facility and picking articles to or putting articles from the robotic units in the order fulfillment facility.", "A material-handling robotic unit that is adapted for use in an order fulfillment facility includes an autonomous mobile vehicle base and a plurality of article receptacles positioned on the base.", "A visual indicator associated with the receptacle facilitates picking articles to or putting articles from the robotic unit." ], [ "1.An order-fulfillment picking method adapted for use in an order fulfillment facility to fulfill orders placed by individuals on-line or from a catalogue, said method comprising: autonomously routing a plurality of autonomous mobile robotic units, wherein said autonomous mobile robotic units are capable of self-navigating without special infrastructure; wherein at least one of said autonomous mobile robotic units comprises a robotic arm and at least one other of said autonomous mobile robotic units comprises a receptacle support; wherein said at least one other of said autonomous mobile robotic units is separate and independent from said at least one of said autonomous mobile robotic units; and transferring articles with said robotic arm of said at least one of said embodiments mobile robotic units to or from a receptacle supported by said receptacle support of said at least one other of said autonomous mobile robotic units.", "2.The method as claimed in claim 1 wherein said autonomous mobile robotic units are adapted to alter planned path of movement in order to function in the presence of persons, wherein said method is performed in the presence of persons.", "3.The method as claimed in claim 1 wherein said receptacle support of said at least one other of said autonomous mobile robotic units comprises a plurality of receptacle supports and wherein said transferring including transferring articles with said robotic arm of said at least one of said autonomous mobile robotic units to or from receptacles at said receptacle supports of said at least one other of said autonomous mobile robotic units.", "4.The method as claimed in claim 3 including an indicator system said indicator system indicating which of the receptacles at said receptacle supports to transfer an article to or from.", "5.The method as claimed in claim 4 wherein said indicator system comprises a plurality of visual indicators each associated with one of said receptacle supports.", "6.The method as claimed in claim 1 wherein at least two of said autonomous mobile robotic units are coupled to travel as a pair of autonomous mobile robotic units.", "7.The method as claimed in claim 6 wherein said at least one of said autonomous mobile robotic units is attachedly coupled to said at least one other of said at least one autonomous mobile robotic units to comprise said pair of autonomous mobile robotic units.", "8.The method as claimed in claim 1 wherein said material-handling facility has a stationary automated order-picking station and including docking some of said autonomous mobile robotic units to said stationary automated order-picking station and receiving articles with said stationary order-picking station from said some of said autonomous mobile robotic units.", "9.The method as claimed in claim 8 wherein said stationary automated order-picking station picks articles directly from said some of said autonomous mobile robotic vehicles.", "10.The method as claimed in claim 1 wherein said at least one other of said autonomous mobile robotic units comprises a plurality of said autonomous mobile robotic units that are attachedly coupled in a train of autonomous mobile robotic units.", "11.The method as claimed in claim 10 wherein said at least one of said other of said autonomous mobile robotic units in said train of autonomous mobile robotic units is a tow vehicle that propels the rest of the other of said autonomous mobile robotic units in said train of autonomous mobile robotic units.", "12.The method as claimed in claim 1 adapted for use in an order fulfillment facility that includes an article storage station, said method including picking articles to said autonomous mobile robotic units from said article storage station and putting articles from said autonomous robotic units to said article storage station wherein said article storage station includes at least one chosen from a manual station, an automated storage and retrieval system, a shuttle-based automated three-dimensional warehouse and a mini-load station.", "13.An order-fulfillment picking method adapted for use in an order fulfillment facility to fulfill orders placed by individuals on-line or from a catalogue, said method comprising: autonomously routing a plurality of autonomous mobile robotic units, wherein said autonomous mobile robotic units are capable of self-navigating without special infrastructure; wherein at least one of said autonomous mobile robotic units comprises a robotic arm and at least one other of said autonomous mobile robotic units comprises a receptacle support; wherein said at least one other of said autonomous mobile robotic units is separate and independent from said at least one of said autonomous mobile robotic units; transferring articles with said robotic arm of said at least one of said autonomous mobile robotic units to or from a receptacle supported by said receptacle support of said at least one other of said autonomous mobile robotic units; and wherein said material-handling facility includes at least one pick station and wherein said transferring articles includes transferring articles with said robotic arm between a receptacle supported by said receptacle support of said at least one other of said autonomous mobile robotic units and said at least one pick station.", "14.The method as claimed in claim 13 wherein said transferring articles includes putting articles to said at least one pick station in order to replenish said at least one pick station.", "15.The method as claimed in claim 13 wherein said transferring articles includes putting articles to said at least one pick station in order to replace articles returned by a customer.", "16.The method as claimed in claim 13 wherein said receptacle support of said at least one other of said autonomous mobile robotic units comprises a plurality of receptacle supports and wherein said transferring articles including picking articles from the pick station with said robotic arm of said at least one of said autonomous mobile robotic units to receptacles at said receptacle supports of said at least one other of said autonomous mobile robotic units or putting articles from receptacles at said receptacle supports with said robotic arm of said at least one of said autonomous mobile robotic to the pick station.", "17.An order fulfillment facility that is adapted to fulfill orders placed by individuals on-line or from a catalogue, said facility comprising: a pick station having items to fulfill orders placed by individuals on-line or from a catalogue; a plurality of autonomous mobile robotic units that are adapted to be autonomously routed in the order fulfillment facility, wherein said autonomous mobile robotic units are capable of self-navigating without special infrastructure; wherein at least one of said robotic units comprises a robotic arm and at least one other of said robotic mobile robotic units comprises a receptacle support; wherein said at least one other of said autonomous mobile robotic units is separate and independent from said at least one of said autonomous mobile robotic units; and wherein said at least one of said robotic units is adapted to transferring articles with said robotic arm between a receptacle supported by said receptacle support of said at least one other of said autonomous mobile robotic units and said pick station.", "18.An order fulfillment facility that is adapted to fulfill orders placed by individuals on-line or from a catalogue, said facility comprising: a pick station having items to fulfill orders placed by individuals on-line or from a catalogue; a plurality of autonomous mobile robotic units that are adapted to be autonomously routed in the order fulfillment facility, wherein said autonomous mobile robotic units are capable of self-navigating without special infrastructure; wherein at least one of said robotic units comprises a robotic arm and at least one other of said robotic mobile robotic units comprises a receptacle support; wherein said at least one other of said autonomous mobile robotic units is separate and independent from said at least one of said autonomous mobile robotic units; and wherein said at least one of said robotic units is adapted to pick articles with said robotic arm from said pick station to a receptacle supported by said receptacle support of said at least one other of said autonomous mobile robotic units to fulfill orders or is adapted to put articles with said robotic arm from a receptacle supported by said receptacle support of said at least one other of said autonomous mobile robotic units to said pick station in order to replenish said pick station.", "19.The order fulfillment facility as claimed in claim 18 wherein said at least one of said autonomous mobile robotic units is both adapted to pick articles with said robotic arm from said pick station to a receptacle supported by said receptacle support of said at least one other of said autonomous mobile robotic units to fulfill orders and is adapted to put articles with said robotic arm from a receptacle supported by said receptacle support of said at least one other of said autonomous mobile robotic units to said pick station in order to replenish said pick station.", "20.A robotic system adapted for use in order fulfillment facility that is adapted to fulfill orders placed by individuals on-line or from a catalogue, the order fulfillment facility having a pick station having items to fulfill orders placed by individuals on-line or from a catalogue; said robotic system comprising: a plurality of autonomous mobile robotic units that are adapted to be autonomously routed in the order fulfillment facility, wherein said autonomous mobile robotic units are capable of self-navigating without special infrastructure; wherein at least one of said robotic units comprises a robotic arm and at least one other of said robotic mobile robotic units comprises a receptacle support; wherein said at least one other of said autonomous mobile robotic units is separate and independent from said at least one of said autonomous mobile robotic units; and wherein said at least one of said robotic units is adapted to transferring articles with said robotic arm between a receptacle supported by said receptacle support of said at least one other of said autonomous mobile robotic units and the pick station." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>The present invention is directed to a method of order picking and an apparatus for use with such method.", "The invention can be used for e-commerce, mail order or phone-in order fulfillment or for split-case picking in a distribution warehouse, or the like.", "Picking of items in a warehouse is typically a labor-intensive activity.", "A number of pickers are provided instructions, using visual displays, voice commands, or the like, that directs the pickers to retrieve a certain number of items from a particular location at a picking shelf or bin.", "The pickers pick the items to receptacles which are then conveyed to order assembly stations, such as a put-station where individual orders are collected and packaged by yet more persons.", "Also, replenishment of the items stocked at the picking facility requires facilities to convey the goods from a decant area where the goods are received in larger containers, such as cases and/or pallets." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention is directed to an order-picking method and material-handling robotic unit that is adapted for use in an order fulfillment facility that is capable of autonomous mobile picking yet is capable of augmentation with humans.", "In this manner, labor costs can be reduced while the installed capital equipment can be sized for a base-line level of orders and capacity added by adding additional humans.", "An order-picking method, according to an aspect of the invention, includes autonomously routing a plurality of mobile robotic units in an order fulfillment facility and picking articles to or putting articles from the robotic units in the order fulfillment facility.", "The picking articles to or putting articles from the robotic units may include manually picking product to or putting product from pick stations in said facility.", "The robotic units may be adapted to alter the planned path of movement in order to function in the presence of the persons, wherein said robotic units and the persons can function together in said order fulfillment facility.", "The robotic unit(s) may include a plurality of receptacle supports, and the method may include picking articles to receptacles at the supports and/or putting articles from the receptacles.", "The indicator system may indicate which of the receptacles to pick an article to or put an article from.", "The indicator system may include a plurality of visual indicators, each associated with one of said receptacles.", "At least one of the robotic units may include a robotic arm and the method include picking articles or putting articles with the robotic arm.", "The method may include picking articles to or putting articles with the robotic arm from another of the robotic units.", "At least one of the robotic units may be coupled to travel with the another of the robotic units as a pair of robotic units.", "The material-handling facility may include at least one pick station and the picking articles may include picking articles from the at least one pick station.", "The putting articles may include putting articles to the at least one pick station in order to replenish the at least one pick station.", "The putting articles may include putting articles to the pick station(s) in order to replace articles returned by a consumer.", "The material-handling facility may have a stationary automated order-picking station and the putting of articles includes docking the robotic units to the order-picking station wherein the order-picking station pick receives articles put from said robotic units.", "The automated order-picking station may pick articles directly from said robotic vehicles.", "A plurality of the robotic units may be coupled in a train of robotic units.", "At least one of the robotic units in the train of robotic units may be a tow vehicle that propels the other of said robotic units in the train of robotic units.", "At least one of the robotic units may be configured to carry at least one pallet and the method may include transporting pallets in the facility with one of the mobile robotic units.", "The facility may include at least one decanting station and picking stations and the method may include picking items to the mobile robotic units at the decanting station and putting items from the mobile robotic units to the picking stations for replenishment of the picking stations.", "The facility may include an article storage station and the method may include picking articles to the mobile robotic units from the storage station and putting articles from the robotic units to the storage station.", "The article storage station may include a manual station, an automated storage and retrieval system, a shuttle-based automated three-dimensional warehouse and/or a mini-load station.", "The method may include picking documents to and putting documents from the mobile robotic units.", "The order fulfilment facility may include a stationary robotic system conducting order fulfilment and/or inventory replenishment operations.", "The stationary robotic system may include a stationary robot and vision equipment to store with the robot to an assignment location product that is retrieved from a receptacle with the robot, or vice versa.", "Receptacles may be supplied to the mobile robotic unit with a conveyor system and a human operator may transfer inventory receptacles between the conveyor system and the mobile robotic unit.", "A human operator may transfer receptacles between the mobile robotic unit and the stationary robotic system.", "The vision equipment may locate the position of the product in two-dimensional (2D) coordinates and using the 2D coordinates as a common reference frame for the vision equipment and the robot and create a three-dimensional (3D) point cloud of product with the vision equipment.", "The vision equipment may use a blob algorithm to identify connected surfaces to identify product.", "A human operator or the stationary robot may retrieve an empty receptacle from the stationary robotic system and move the empty receptacle to or from the assignment location.", "A human operator may load an empty receptacle from the assignment location as directed by an indicator system to complete the order.", "A rail-supported vehicle may remove a completed receptacle from the pick or put operation.", "A material-handling robotic unit that is adapted for use in an order fulfillment facility, according to an aspect of the invention, includes an autonomous mobile vehicle base and a plurality of article receptacles positioned on the base.", "A visual indicator associated with the receptacle facilitates picking articles to or putting articles from the robotic unit.", "These and other objects, advantages and features of this invention will become apparent upon review of the following specification in conjunction with the drawings." ], [ "CROSS REFERENCE TO RELATED APPLICATION The present application is a continuation of U.S. patent application Ser.", "No.", "15/372,636, filed on Dec. 8, 2016, which is a division of U.S. patent application Ser.", "No.", "14/479,908, filed on Sep. 8, 2014, now U.S. Pat.", "No.", "9,550,624, issued Jan. 24, 2017, which claims priority from U.S. patent application Ser.", "No.", "61/875,341, filed on Sep. 9, 2013, the disclosure of which is hereby incorporated herein by reference.", "BACKGROUND OF THE INVENTION The present invention is directed to a method of order picking and an apparatus for use with such method.", "The invention can be used for e-commerce, mail order or phone-in order fulfillment or for split-case picking in a distribution warehouse, or the like.", "Picking of items in a warehouse is typically a labor-intensive activity.", "A number of pickers are provided instructions, using visual displays, voice commands, or the like, that directs the pickers to retrieve a certain number of items from a particular location at a picking shelf or bin.", "The pickers pick the items to receptacles which are then conveyed to order assembly stations, such as a put-station where individual orders are collected and packaged by yet more persons.", "Also, replenishment of the items stocked at the picking facility requires facilities to convey the goods from a decant area where the goods are received in larger containers, such as cases and/or pallets.", "SUMMARY OF THE INVENTION The present invention is directed to an order-picking method and material-handling robotic unit that is adapted for use in an order fulfillment facility that is capable of autonomous mobile picking yet is capable of augmentation with humans.", "In this manner, labor costs can be reduced while the installed capital equipment can be sized for a base-line level of orders and capacity added by adding additional humans.", "An order-picking method, according to an aspect of the invention, includes autonomously routing a plurality of mobile robotic units in an order fulfillment facility and picking articles to or putting articles from the robotic units in the order fulfillment facility.", "The picking articles to or putting articles from the robotic units may include manually picking product to or putting product from pick stations in said facility.", "The robotic units may be adapted to alter the planned path of movement in order to function in the presence of the persons, wherein said robotic units and the persons can function together in said order fulfillment facility.", "The robotic unit(s) may include a plurality of receptacle supports, and the method may include picking articles to receptacles at the supports and/or putting articles from the receptacles.", "The indicator system may indicate which of the receptacles to pick an article to or put an article from.", "The indicator system may include a plurality of visual indicators, each associated with one of said receptacles.", "At least one of the robotic units may include a robotic arm and the method include picking articles or putting articles with the robotic arm.", "The method may include picking articles to or putting articles with the robotic arm from another of the robotic units.", "At least one of the robotic units may be coupled to travel with the another of the robotic units as a pair of robotic units.", "The material-handling facility may include at least one pick station and the picking articles may include picking articles from the at least one pick station.", "The putting articles may include putting articles to the at least one pick station in order to replenish the at least one pick station.", "The putting articles may include putting articles to the pick station(s) in order to replace articles returned by a consumer.", "The material-handling facility may have a stationary automated order-picking station and the putting of articles includes docking the robotic units to the order-picking station wherein the order-picking station pick receives articles put from said robotic units.", "The automated order-picking station may pick articles directly from said robotic vehicles.", "A plurality of the robotic units may be coupled in a train of robotic units.", "At least one of the robotic units in the train of robotic units may be a tow vehicle that propels the other of said robotic units in the train of robotic units.", "At least one of the robotic units may be configured to carry at least one pallet and the method may include transporting pallets in the facility with one of the mobile robotic units.", "The facility may include at least one decanting station and picking stations and the method may include picking items to the mobile robotic units at the decanting station and putting items from the mobile robotic units to the picking stations for replenishment of the picking stations.", "The facility may include an article storage station and the method may include picking articles to the mobile robotic units from the storage station and putting articles from the robotic units to the storage station.", "The article storage station may include a manual station, an automated storage and retrieval system, a shuttle-based automated three-dimensional warehouse and/or a mini-load station.", "The method may include picking documents to and putting documents from the mobile robotic units.", "The order fulfilment facility may include a stationary robotic system conducting order fulfilment and/or inventory replenishment operations.", "The stationary robotic system may include a stationary robot and vision equipment to store with the robot to an assignment location product that is retrieved from a receptacle with the robot, or vice versa.", "Receptacles may be supplied to the mobile robotic unit with a conveyor system and a human operator may transfer inventory receptacles between the conveyor system and the mobile robotic unit.", "A human operator may transfer receptacles between the mobile robotic unit and the stationary robotic system.", "The vision equipment may locate the position of the product in two-dimensional (2D) coordinates and using the 2D coordinates as a common reference frame for the vision equipment and the robot and create a three-dimensional (3D) point cloud of product with the vision equipment.", "The vision equipment may use a blob algorithm to identify connected surfaces to identify product.", "A human operator or the stationary robot may retrieve an empty receptacle from the stationary robotic system and move the empty receptacle to or from the assignment location.", "A human operator may load an empty receptacle from the assignment location as directed by an indicator system to complete the order.", "A rail-supported vehicle may remove a completed receptacle from the pick or put operation.", "A material-handling robotic unit that is adapted for use in an order fulfillment facility, according to an aspect of the invention, includes an autonomous mobile vehicle base and a plurality of article receptacles positioned on the base.", "A visual indicator associated with the receptacle facilitates picking articles to or putting articles from the robotic unit.", "These and other objects, advantages and features of this invention will become apparent upon review of the following specification in conjunction with the drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a perspective view of an order-picking method according to an embodiment of the invention; FIG.", "2 is the same view as FIG.", "1 of an alternative embodiment thereof; FIG.", "3 is the same view as FIG.", "1 of another alternative embodiment thereof; FIG.", "4 is a perspective view of a material-handling robotic unit; FIG.", "5 is the same view as FIG.", "4 taken from an opposite direction; FIG.", "6 is a diagram illustrating split case and item level picking functions; FIG.", "7 is a diagram illustrating split case and item level picking functions in combination with full case picking function; FIG.", "8 is a diagram illustrating decanting and de-trashing functions; FIG.", "9 is a perspective view of an automated order-picking station useful with the method; FIG.", "10 is a perspective view of an automated order-picking or replenishment station; and FIG.", "11 is a top plan view of the station in FIG.", "10.DESCRIPTION OF THE PREFERRED EMBODIMENT Referring now to the drawings and the illustrative embodiments depicted therein, an order-picking method 10 is carried out in an order fulfillment facility 12 using a plurality of mobile robotic units 14 operating autonomously or semi-autonomously in order fulfillment facility 12.The term “order fulfillment facility” is intended to be used in a broad sense of the term to include fulfillment of orders placed by individuals, which typically involve one or more individual items ordered on-line or through a catalog, as well as full case and split case orders that are bound for individual stores of a chain of retail establishments, or the like.", "Robotic units 14 are especially configured to facilitate picking articles to the robotic unit.", "It may also be used for putting articles from the robotic units in the order fulfillment facility.", "Method 10 may include manually picking product to or putting product from receptacles in facility 12 using humans illustrated at 16.This is feasible because robotic units 14 are adapted to alter planned path of movement in the presence of the humans.", "In this manner, robotic units 14 and humans 16 can function together in said order fulfillment facility.", "In the illustrated embodiment, robotic units 14 include an autonomous vehicle base 17 that is marketed by Adept Technology, Inc. under the Lynx brand, although other autonomous vehicles may be used.", "Autonomous vehicle base 17 is capable of self-navigation from any starting point in fulfillment facility 12 to any utilization point without special infrastructure, such as magnets, stationary lasers, or the like.", "Also, autonomous vehicle base 17 is capable of sensing humans and unanticipated obstructions and modifying its path plan to avoid the human/obstruction without any further intervention.", "Robotic units 14 include a plurality of receptacle supports 18 that may be positioned on one or both sides of the vehicle.", "Articles may be picked to receptacles, such as totes or cartons placed on supports 18, such as part of a pick function.", "For example, split case and item level pick functions 32 may be carried out.", "Articles may also be taken from receptacles on supports 18, such as part of a put function.", "For example, articles may be taken from receptacles on supports 18 and combined as customer orders in a put operation, such as at a conventional put wall, goods-to-person station, or the like.", "Moreover, supports 18 can be at a horizontal position thereby allowing the receptacles supported thereon to be horizontal.", "This allows the receptacles to interface with other material-handling equipment, such as conveyors, vehicles, or the like.", "In order to facilitate such pick and put function, robotic units 14 may include an indicator system 20.Indicator system 20 indicates which of receptacles on supports 18 to pick an article to or which of receptacles on supports 18 to take, or put, an article from.", "In the illustrated embodiment, indicator system 20 includes a series of visual indicators, such as lamps, each associated with one of supports 18 to inform an operator which receptacle to put item(s) to or retrieve item(s) from.", "In addition, or alternatively, robotic units 14 include an interface unit 23 that may be used to display to an operator information, such as a number of each item to be picked.", "It may also receive operator input, such as confirmation of the number of units picked, or the like.", "In the illustrated embodiment, interface unit 23 is a portable digital device, such as a computer table of the type known in the art and marketed by various companies, such as the Apple iPad, and the like.", "Additionally, instructions to a pick/put operator may be supplied using voice picking as is known in the art.", "Method 10 may include robotic units 114 that include a robotic arm 24.Robotic arm 24 is capable of picking articles to a robotic unit 14 or putting articles from a robotic unit 14.Robotic arm is a 6-axis articulated robot, such as marketed by various manufactures, such as Adept Technologies, Inc. under a Viper mark.", "However, 4-axis robots can be used for some applications.", "Robotic arm 24 uses machine vision to identify the position of an item to pick up and/or to identify the item to be picked.", "A robotic unit 114 having an arm 24 may be coupled with a robotic unit 14 and operated as a combined unit with arm 24 picking to or putting from receptacles on supports 18 on robotic unit 14, as best illustrated in FIG.", "2.FIG.", "2 illustrates robotic arm 24 picking articles from a pick station 25.Thus, the entire pick and/or put function can be carried out automatically without human intervention.", "However, for peak flow periods, humans 16 may be added to method 10 and used along side the robotic units.", "Method 10 may further includes a plurality of trains 26 made up of slave robotic units 30 that are coupled in a train of robotic units with a master robotic unit 28.In this fashion, master robotic unit 28 functions as a tow vehicle to propel slave units 30.Other variations of robotic units are deemed to be comprehended herein.", "For example, at least one of the robotic units may be configured to carry at least one pallet and the method including transporting pallets in facility 10.A split case/item level pick function 32 is illustrated in FIG.", "6.In such function, the robotic units are used in a pick tunnel 31 with or without humans to pick from pick stations 25.Other mobile robotic units are used in replenishment aisles 33 in order to replenish at least one pick stations 25.Function 32 is useful for picking discrete sort orders where each receptacle represents a store destination.", "It may also be used to batch pick to a tote or carton whether the tote/carton is destined to a put wall or a goods-to-person station for multi-line order consolidation.", "It was also to be used to batch pick to a tote or carton for single line orders where the tote or carton is destined to a packing and shipping function.", "Higher levels of warehouse management software may be used to establish priority level of control of method 10 for managing overall material flow and order fulfillment.", "A full case pick function 34 can be added as seen in FIG.", "7.Function 34 includes a full case pick station 125 that utilizes the mobile robotic units to carry a pallet to pick locations 125.This function may be used for discrete store orders where a tote or carton represents a store destination or where the pallet is built in a store or aisle-ready format.", "Replenishment of pick locations 125 can take place by mobile robotic vehicles in a replenishment aisle 133.As can be seen in FIG.", "8, replenishment function 36 involves items being placed in a receptacle 18, such as a tote or carton, and routed to pick station 25 or to a storage area 125.A decant and de-trash function 38 may be provided.", "The mobile robotic units can also be used with an automated pick station 40, as illustrated in FIG.", "9.Pick station 40 includes a stationary picking arm 42 for use in picking items from a supply tote or carton and placing the items in order totes or cartons.", "A mobile robotic unit 14 (not shown in FIG.", "9) can be docked along side of pick station 40 with picking arm 42 picking directly from receptacles 18 and placing the picked items directly to an order tote, or the like.", "Other functions are possible.", "For example, method 10 may include picking of documents to a robotic unit 14 and putting documents from the robotic units to a destination.", "The mobile robotic units can also be used with an order picking method 210 having a stationary robotic system 240 with a stationary robot, such as stationary picking arm 242 that is used for conducting order fulfilment and/or inventory replenishment operations (FIGS.", "10 and 11).", "Stationary robotic system 240 includes vision equipment, or system, 244 to identify items to be picked from a receptacle 218 and to instruct arm 242 to pick the item and move the item to an assignment location 246 in a put wall 250.While the embodiment is illustrated as moving items from a receptacle to a put wall 250, the opposite could be provided, wherein items are identified in assignment locations 246, retrieved by the robot arm and placed into receptacles 218.In the illustrated embodiment, receptacles 218 are received from conveyor system 248, such as from a batch picking operation in which pickers pick all or a portion of items for a customer order, thereby making receptacles 218 “dirty pick” receptacles, meaning that they contain a number of heterogeneous items that are destined for more than one customer order and may contain only portions of a number of orders.", "Receptacles 218 are moved by a human operator from conveyor system 248 to mobile robotic unit 214 that has the same general characteristics as mobile robotic unit 14.Mobile robotic unit 214 transports receptacles to a conveyor system 254 where the receptacles are unloaded for conveying, such as past vision system 244.Conveyor system 254 may utilize a variety of conveying techniques, such as segmented belts, powered roller and/or a right angle transfer 258.The transfer from mobile robotic unit 214 can be by a human operator or by a robot (not shown).", "Conveyor system 254 transports the receptacles past vision system 244 where the items in the receptacle are identified and picked by robot 242.Robot 242 places the items in assignment locations 246, which are open on opposite sides to be accessible on one side by robot 242 and the opposite side by a human.", "A warehouse management system (not shown) instructs robot 242 which assignment location 246 to place the item picked from the receptacle.", "When all of the items are removed from a receptacle in this manner, the empty receptacle is then transported to a conveyor system 256 where an operator can use the empty receptacle to unload a completed order from an assignment location 246.Interlocks, such as proximity detectors, light curtains, or the like, prevent robot arm 242 from entering an assignment location 246 that has is being accessed by an operator.", "Similarly, a warning system, such as a light on put wall 250, informs the operator when the robot is placing an item in an assignment location so that the operator does not try to retrieve items from any assignment location while the robot arm is entering any assignment location.", "Other lights or a display may be used to inform the operator when a group of items, such as an order, is complete and ready to be loaded from its assignment location 246 to an empty receptacle.", "The processed receptacle is then transported by conveyor system 254 to a rail-supported vehicle 252 to be transported, such as to a pack-out station, automated storage or to replenish items in a pick-to-light fulfillment system.", "In the illustrated embodiment, rail supported vehicle 252 is a belt-shuttle as disclosed in International Patent Application Publication No.", "WO 2012/044734 A1, the disclosure of which is hereby incorporated herein by reference.", "Vision system 244 locates the position of an item in two-dimensional (2D) coordinates and uses the 2D coordinates as a common reference frame for the vision equipment and the robot.", "The vision system creates a three-dimensional (3D) point cloud of items and uses a blob algorithm to identify connected surfaces in order to identify individual items.", "An end-of-arm tool, such as a vacuum-operated device, is used by stationary picking arm 242 to pick up the desired item.", "The vacuum is relieved in order to deposit the item in the selected assignment location 246.Vision system 244 and robot 142 are commercially available from several suppliers and may be provided as an integral unit in order to facilitate the coordinated operation.", "It should be understood that certain functions described as performed with mobile robotic unit 214 could be carried out by a human and certain functions described as performed with a human could be performed with a robotic unit.", "While the foregoing description describes several embodiments of the present invention, it will be understood by those skilled in the art that variations and modifications to these embodiments may be made without departing from the spirit and scope of the invention, as defined in the claims below.", "The present invention encompasses all combinations of various embodiments or aspects of the invention described herein.", "It is understood that any and all embodiments of the present invention may be taken in conjunction with any other embodiment to describe additional embodiments of the present invention.", "Furthermore, any elements of an embodiment may be combined with any and all other elements of any of the embodiments to describe additional embodiments." ] ]
Patent_15874194
[ [ "TERMINAL DEVICE, BASE STATION DEVICE, AND COMMUNICATION METHOD", "A terminal device is equipped with: a sequence determination unit that determines a sequence number with a different pattern than the assignment pattern for the sequence number assigned to the cell in which the host device resides; a reference signal generation unit that generates a reference signal for a sequence group corresponding to the sequence number that has been determined; and a wireless transmission unit that transmits the reference signal that has been generated to a base station.", "The sequence determination unit employs a configuration whereby, with the sequence number assigned to the cell in which the host device resides as a cell-specific sequence number, a dynamic offset which periodically changes over time and for which the same value is not consecutive is added to the cell-specific sequence number, thereby determining a sequence number which never overlaps with the cell-specific sequence number." ], [ "1.A radio communication terminal comprising: a controller, which, in response to receiving signaling specific to the radio communication terminal, determines a base sequence group based on the received signaling; and in response to not receiving signaling specific to the radio communication terminal, determines a base sequence group which is allocated to a cell that contains the radio communication terminal; wherein the controller, in operation, generates a sounding reference signal (SRS) using the determined base sequence group; and a transmitter, which is coupled to the controller and which, in operation, transmits the generated SRS.", "2.The radio communication terminal according to claim 1, wherein the signaling specific to the radio communication terminal is received before the transmitter transmits the generated SRS.", "3.The radio communication terminal according to claim 1, wherein the controller, in response to receiving new signaling specific to the radio communication terminal, updates the determined base sequence group based on the new signaling and generates another SRS using the updated base sequence group.", "4.The radio communication terminal according to claim 1, wherein a first range of the base sequence group determined based on the signaling specific to the radio communication terminal is different from a second range of the base sequence group allocated to the cell that contains the radio communication terminal.", "5.The radio communication terminal according to claim 4, wherein the first range and the second range do not overlap.", "6.The radio communication terminal according to claim 1, wherein the base sequence group determined based on the signaling specific to the radio communication terminal does not overlap with the base sequence group allocated to the cell that contains the radio communication terminal.", "7.The radio communication terminal according to claim 1, wherein the base sequence group determined based on the signaling specific to the radio communication terminal is different from the base sequence group allocated to the cell that contains the radio communication terminal.", "8.The radio communication terminal according to claim 1, wherein the base sequence group determined based on the signaling specific to the radio communication terminal has a hopping pattern different from that of a base sequence group allocated to a cell belonging to another cell cluster, which is different from a cell cluster including the cell that contains the radio communication terminal.", "9.The radio communication terminal according to claim 1, wherein the signaling specific to the radio communication terminal includes 9 bits of a cell ID.", "10.A radio communication terminal comprising: a receiver, which, in operation, receives an instruction specifically signaled to the radio communication terminal by a Radio Resource Control (RRC) layer, the instruction including a parameter of a sequence number; a controller, which is coupled to the receiver and which, in operation, configures a sequence number based on the received instruction, ignoring a sequence number allocated to a cell that contains the radio communication terminal, and generates a Sounding Reference Signal (SRS) of a sequence group corresponding to the configured sequence number; and a transmitter, which is coupled to the controller and which, in operation, transmits the generated SRS.", "11.The radio communication terminal according to claim 10, wherein the instruction includes a sequence number hopping pattern different from that of another cell cluster, which is different from a cell cluster including the radio communication terminal, and wherein a number of times sequence numbers respectively allocated to neighboring cells overlap with the configured sequence number of the radio communication terminal in one cycle period of cyclically repeated sequence number allocation is not concentrated in any one of the neighboring cells.", "12.The radio communication terminal according to claim 11, wherein a difference among the numbers of times sequence numbers respectively allocated to neighboring cells overlap with the configured sequence number of the radio communication terminal in one cycle period is at most three.", "13.A method performed by a radio communication terminal, the method comprising: in response to receiving signaling specific to the radio communication terminal, determining a base sequence group based on the received signaling; in response to not receiving signaling specific to the radio communication terminal, determining a base sequence group which is allocated to a cell that contains the radio communication terminal; generating a sounding reference signal (SRS) using the determined base sequence group; and transmitting the generated SRS.", "14.The method according to claim 13, wherein the signaling specific to the radio communication terminal is received before the generated SRS is transmitted.", "15.The method according to claim 13, comprising: in response to receiving new signaling specific to the radio communication terminal, updating the determined base sequence group based on the new signaling and generating another SRS using the updated base sequence group.", "16.The method according to claim 13, wherein a first range of the base sequence group determined based on the signaling specific to the radio communication terminal is different from a second range of the base sequence group allocated to the cell that contains the radio communication terminal.", "17.The method according to claim 16, wherein the first range and the second range do not overlap.", "18.The method according to claim 13, wherein the base sequence group determined based on the signaling specific to the radio communication terminal does not overlap with the base sequence group allocated to the cell that contains the radio communication terminal.", "19.The method according to claim 13, wherein the base sequence group determined based on the signaling specific to the radio communication terminal is different from the base sequence group allocated to the cell that contains the radio communication terminal.", "20.The method according to 13, wherein the base sequence group determined based on the signaling specific to the radio communication terminal has a hopping pattern different from that of a base sequence group allocated to a cell belonging to another cell cluster, which is different from a cell cluster including the cell that contains the radio communication terminal.", "21.The method according to claim 13, wherein the signaling specific to the radio communication terminal includes 9 bits of a cell ID.", "22.A method performed by a radio communication terminal, the method comprising: receiving an instruction specifically signaled to the radio communication terminal by a Radio Resource Control (RRC) layer, the instruction including a parameter of a sequence number; configuring a sequence number based on the received instruction, ignoring a sequence number allocated to a cell that contains the radio communication terminal; generating a Sounding Reference Signal (SRS) of a sequence group corresponding to the configured sequence number; and transmitting the generated SRS.", "23.The method according to claim 22, wherein the instruction includes a sequence number hopping pattern different from that of another cell cluster, which is different from a cell cluster including the radio communication terminal, and wherein a number of times sequence numbers respectively allocated to neighboring cells overlap with the configured sequence number of the radio communication terminal in one cycle period of cyclically repeated sequence number allocation is not concentrated in any one of the neighboring cells.", "24.The method according to claim 23, wherein a difference among the numbers of times sequence numbers respectively allocated to neighboring cells overlap with the configured sequence number of the radio communication terminal in one cycle period is at most three." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> BRIEF SUMMARY <EOH>" ], [ "BACKGROUND Technical Field The present invention relates to a terminal apparatus, a base station apparatus, and a communication method each used for transmitting a reference signal.", "Description of the Related Art LTE (Long Term Evolution) Rel.", "8 (Release 8) developed in 3GPP (3rd Generation Partnership Project Radio Access Network) employs SC-FDMA (single-carrier frequency-division multiple-access) involving a low PAPR (peak-to-average power ratio) and high electric-power use efficiency of a terminal apparatus (also referred to as UE) as an uplink communication scheme (refer to Non-Patent Literatures (hereinafter, abbreviated as NPLs) 1, 2, and 3).", "In the uplink of LTE, both a data signal of PUSCH (Physical Uplink Shared Channel) and a control signal of a PUCCH (Physical Uplink Control Channel) are transmitted on a per-subframe basis (refer to NPL 1).", "Each subframe includes two time slots.", "In each time slot, a plurality of SC-FDMA symbols and a DMRS (demodulation reference signal, also abbreviated as DRS) as one of the reference signals are time-multiplexed.", "FIG.", "1 illustrates an example of a subframe configuration of a PUSCH to which normal cyclic prefix is applied.", "Upon reception of a data signal on the PUSCH, the base station performs channel estimation using a DMRS.", "The result of channel estimation result is used to demodulate and decode an SC-FDMA symbol.", "In addition, in LTE-A (LTE-Advanced) Rel.", "10 (Release 10), DFTS-OFDM (discrete-Fourier-transform spread orthogonal frequency division multiplexing), which is an extended version of SC-FDMA, has also become available.", "This is a method of dividing into two spectra the data signals of the PUSCH obtained as illustrated in FIG.", "1, and mapping the divided signals to different frequencies, and thereby expanding the flexibility of scheduling without any change in the configuration of the PUSCH from that of SC-FDMA.", "On the other hand, the control signal of PUCCH has a plurality of formats each having a subframe configuration different from that of PUSCH (refer to NPL 1).", "Any one of the formats involves a subframe consisting of two slots, and each slot includes a plurality of SC-FDMA symbols and a plurality of DMRSs.", "The control signal of PUCCH is demodulated on the basis of a channel estimation result using the DMRS similarly to the data signal of PUSCH.", "In order to correctly decode information transmitted on the PUSCH and PUCCH, highly precise channel estimation by the DMRS is indispensable.", "In Rel.", "10 of LTE-A, the DMRSs of different UEs connected to the single cell are transmitted while different cyclic shifts (CSs, equivalent to phase rotations) or orthogonal codes (also referred to as orthogonal cover codes (OCCs)) are allocated to the DMRSs.", "Accordingly, these DMRSs can be orthogonally multiplexed and orthogonally demultiplexed.", "On the other hand, the DMRSs transmitted by different UEs connected to different cells cannot be demultiplexed.", "Therefore, in order to suppress inter-cell interference and to perform highly precise channel estimation, it is necessary to use different signal sequences having a small correlation between different cells.", "Consequently, in Rel.", "8-10 of LTE-A, 30 different base sequence groups mutually having low correlations are defined and are respectively allocated to cells.", "Moreover, in order to avoid causing uneven magnitude of interference, sequence group hopping that changes the sequence group used for every time slot is introduced.", "The base sequence group refers to a group including a plurality of base sequences having a plurality of sequence lengths.", "Moreover, the sequence group refers to a group obtained by gathering a plurality of signal sequences obtained by cyclically shifting all the respective base sequences in one base sequence group.", "Therefore, allocating a base sequence group to a cell means the same as allocating a sequence group corresponding to the base sequence group to the cell.", "FIG.", "2 illustrates the feature of a sequence group allocated to each cell.", "For example, when Ncell ID represents a cell-specific identifier ID (cell ID number), a sequence group corresponding to a number given by the following expression is allocated in an ns-th slot in the cell.", "[1] u=(fgh(ns)+fss)mod 30,ns=0˜19 (Expression 1) In expression 1, fgh(ns) is a hopping pattern represented with a sequence group determined by a PN (pseudo-random) sequence having an initial value equal to an integer value obtained by truncating Ncell ID/30 after the decimal point, and Ncell ID is given by an integer of 0 to 503.Offset fss is an integer determined by the following expression, and is provided to each cell.", "[ 2 ] f ss = { N cell   ID  mod   30 for   PUCCH N cell   ID + Δ ss  mod   30 for   PUSCH ( Expression   2 ) In expression 2, Δss is one of the integers of 0 to 29 and is indicated to a UE as a cell-specific parameter.", "The sequence group hopping can also be disabled (that is, setting fgh(ns)=0) on a per-cell basis or on a per-UE basis.", "The following is found from the above.", "1.In many cells included in a system, according to 504 pieces of different Ncell ID, 30 sequence groups are repeatedly used in different cells.", "2.A sequence hopping pattern (fgh(ns)) is the same among 30 cells having continuous Ncell ID, and the hopping patterns of sequence groups are different between the cells having an interval of Ncell ID equal to or more than 30.A cell group with the same hopping pattern (fgh(ns)) constitutes a cell cluster.", "3.In one cell cluster, offset fss varies from cell to cell in principle.", "In other words, this is equal to using patterns obtained by applying cell-specific sequence offset fss to a common sequence group hopping pattern.", "FIG.", "3 illustrates an example of sequence group hopping.", "FIG.", "3 illustrates hopping patterns of a sequence group used in a cell cluster including Ncell ID=0 to 29.For the sake of simplicity, it is assumed that Δss=0 in all cells.", "As illustrated in FIG.", "3, a hopping pattern is common in one cell cluster, but a different sequence offset is given according to the value of Ncell ID.", "Therefore, in a cell cluster, a different sequence group is always used in a different cell.", "Moreover, hopping patterns themselves differ in different cell clusters.", "Therefore, in cells in different cell clusters, even if sequence groups overlap, causing an increase in interference, the interference does not continue over a plurality of slots.", "The base sequence group allocated to each cell in this way is used, for example, for an uplink SRS (sounding reference signal) that is one of the reference signals and modulation of a PUCCH in addition to the DMRS.", "CITATION LIST Non-Patent Literatures NPL 1 3GPP TS 36.211 V10.4.0, “Physical Channels and Modulation (Release 10),” December 2011 NPL 2 3GPP TS 36.212 V10.4.0, “Multiplexing and channel coding (Release 10),” December 2011 NPL 3 3GPP TS 36.213 V10.4.0, “Physical layer procedures (Release 10),” December 2011 BRIEF SUMMARY Technical Problem CoMP reception (coordinated multipoint reception) has been discussed in Rel.", "11 (Release 11) of LTE-A.", "The CoMP reception is a scheme that causes a plurality of base stations (also referred to as reception points (RPs)) to receive a PUSCH data signal and a PUCCH control signal from a UE and to combine these signals, thereby improving the throughput.", "In particular, the CoMP reception is effective in a heterogeneous network (HetNet) environment where a pico cell or RRH (remote radio head) having a smaller coverage is placed in a macro cell.", "This is because large interference caused between a macro cell and a pico cell and considered as a problem in HetNet can be combined as a desired signal when the CoMP reception is performed.", "As uplink CoMP in HetNet, an operation giving different Ncell ID to macro cells and pico cells (CoMP scenario 3) and an operation giving the same Ncell ID (CoMP scenario 4) are discussed.", "In the case of CoMP scenario 3, as illustrated in FIG.", "4, UEs use different sequence groups according to the connected macro cell and pico cell.", "At this time, if cells connected to a plurality of UEs to be simultaneously subjected to CoMP reception are different, and different sequence groups are used for DMRSs of the UEs, the DMRSs cannot be orthogonally demultiplexed, which results in deterioration of channel estimation accuracy due to interference.", "On the other hand, in the case of CoMP scenario 4, as illustrated in FIG.", "5, all UEs in a macro area use the same sequence group.", "Therefore, unlike CoMP scenario 3, different UEs use signal sequences obtained by cyclically shifting one base sequence using different shift amounts, thereby enabling orthogonal demultiplexing of DMRSs of the different UEs.", "However, only one sequence group can be used in a macro area, and therefore the number of usable signal sequences may be insufficient if the number of UEs increases.", "In order to solve such problems described above, enabling allocation of another base sequence to the UEs is discussed.", "FIG.", "6 explains an example in which some of the UEs use a base sequence not included in a base sequence group allocated to the cell under the HetNet environment.", "FIG.", "6 does not illustrate UEs using a base sequence group allocated to the cell but illustrates only UEs using a base sequence not allocated thereto.", "However, such a favorable method of allocating a base sequence has not been found yet.", "It is an object of the present invention to provide a terminal apparatus, a base station apparatus, and a communication method that can secure a large number of signal sequences that can be used by UEs in one cell without increasing deterioration of the process accuracy (deterioration of channel estimation accuracy in case of DMRSs and deterioration of estimation accuracy of channel quality in case of SRSs) due to interference to the reference signals.", "Solution to Problem A terminal apparatus according to an aspect of the present invention is configured to communicate with a base station in a communication system in which a plurality of reference signals of a plurality of sequence groups are beforehand determined in association with a plurality of sequence numbers, the sequence numbers each having an offset added thereto are allocated to cells, the offset temporally varies depending on a hopping pattern that is common in one cell cluster and that is different among a plurality of cell clusters, and the offset is different from those of other cells belonging to the same cell cluster, the apparatus comprising: a sequence determination section that determines the sequence number using a pattern that is different from an allocation pattern of the sequence number allocated to the cell which contains the terminal apparatus; a reference signal generation section that generates a reference signal of the sequence group corresponding to the determined sequence number; and a radio transmission section that transmits the generated reference signal to the base station, wherein the sequence determination section determines the sequence number that does not overlap with a cell-specific sequence number always, by adding a variable offset that regularly varies depending on time and that does not have the same value continuously, wherein the cell-specific sequence number is the sequence number allocated to the cell which contains the terminal apparatus.", "A base station apparatus according to an aspect of the present invention is an apparatus in a communication system in which a plurality of reference signals of a plurality of sequence groups are beforehand determined in association with a plurality of sequence numbers, the sequence numbers each having an offset added thereto are allocated to cells, the offset temporally varies depending on a hopping pattern that is common in one cell cluster and that is different among a plurality of cell clusters, and the offset is different from those of other cells belonging to the same cell cluster, the apparatus comprising: a reception section that receives a radio signal from a terminal apparatus; and a signal extraction section that extracts the reference signal from the received radio signal, wherein the reference signal extracted by the signal extraction section includes the reference signal transmitted from the terminal apparatus in association with the sequence number which is determined by adding a cell-specific sequence number to a variable offset that regularly varies depending on time and that does not have the same value continuously, the determined sequence number not overlapping with the cell-specific sequence number always, wherein the cell-specific sequence number is the sequence number allocated to the cell which contains the terminal apparatus.", "A communication method according to an aspect of the present invention is a method used in a communication system in which a plurality of reference signal of a plurality of sequence groups are beforehand determined in association with a plurality of sequence numbers, the sequence numbers each having an offset added thereto are allocated to cells, the offset temporally varies depending on a hopping pattern that is common in one cell cluster and that is different among a plurality of cell clusters, and the offset is different from those of other cells belonging to the same cell cluster, the method comprising: determining the sequence number that does not overlap with a cell-specific sequence number always, by adding a variable offset that regularly varies depending on time and that does not have the same value continuously to the cell-specific sequence number by a terminal apparatus, wherein the cell-specific sequence number is the sequence number allocated to the cell which contains the terminal apparatus; generating the reference signal of the sequence group corresponding to the determined sequence number by the terminal apparatus; transmitting the generated reference signal to a base station by the terminal apparatus; and receiving the transmitted reference signal by the base station.", "Advantageous Effects of Invention The present invention can secure a large number of signal sequences that can be used by UEs in one cell without increasing deterioration of channel estimation accuracy or estimation accuracy of channel quality due to interference in reference signals.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a subframe configuration of a PUSCH to which a normal cyclic prefix is applied; FIG.", "2 illustrates the feature of a sequence group allocated to each cell; FIG.", "3 illustrates an example of sequence group hopping; FIG.", "4 is an explanatory diagram illustrating an example operation of CoMP scenario 3; FIG.", "5 is an explanatory diagram illustrating an example operation of CoMP scenario 4; FIG.", "6 explains an example in which some UEs use a base sequence not included in a base sequence group allocated to the cell under the HetNet environment; FIG.", "7 is a functional block diagram illustrating a main part of an RP according to an embodiment of the present invention; FIG.", "8 is a block diagram illustrating the details of the RP according to the embodiment of the present invention; FIG.", "9 is a functional block diagram illustrating a main part of a terminal apparatus according to an embodiment of the present invention; FIG.", "10 is a block diagram illustrating the details of the terminal apparatus according to the embodiment of the present invention; FIG.", "11 illustrates the situation of interference between a sequence group allocated by signaling for an individual terminal and a sequence group allocated to the cell in Embodiment 1; FIG.", "12 explains the relationship between a first example of a sequence group allocated by signaling for an individual terminal and a sequence group allocated to the cell in Embodiment 2; FIG.", "13 explains a second example of a sequence group allocated by signaling for an individual terminal in Embodiment 2; FIG.", "14 explains a third example of a sequence group allocated by signaling for an individual terminal in Embodiment 2; FIG.", "15 illustrates a sequence group allocated by signaling for an individual terminal in Embodiment 3; FIG.", "16 illustrates a sequence group allocated by signaling for an individual terminal in Embodiment 6; and FIG.", "17 illustrates a sequence group allocated by signaling for an individual terminal in Embodiment 7.DETAILED DESCRIPTION Each embodiment of the present invention will be explained below in detail with reference to the accompanying drawings.", "Embodiment 1 [Outline of Communication System] A communication system according to the present embodiment includes a plurality of RPs 10 distributed at many points and a plurality of terminal apparatuses 20 moving freely around the respective points.", "The plurality of RPs 10 are placed at many points so that each macro cell can cover the almost entire moving ranges of the UEs.", "Each macro cell is supplied with 504 kinds of cell IDs (Ncell ID=0 to 503), and a plurality of cell clusters are configured by grouping the macro cells into 30 continuous macro cells.", "The present embodiment can also be applied to the case of CoMP scenario 3 allocating different cell IDs respectively to placed RPs 10 in addition to macro cells, in the completely same way.", "If focusing on only a region around one terminal apparatus 20, the communication system according to the present embodiment includes one or more RPs 10 and terminal apparatus 20 in the macro cell.", "Here, when the plurality of RPs 10 are provided, the plurality of RPs 10 are connected through interfaces, such as optical fibers, having a low delay and a large capacity.", "RP 10 may be a macro base station covering the range of a macro cell and may be a pico base station covering the range of a pico cell.", "Alternatively, RP 10 may be a receiver that is connected to a network and used for uplink reception.", "Terminal apparatus 20 and RP 10 transmitting and receiving the PUSCH are mutually determined by a prior hand-over process and a prior control process.", "[Configuration of RP 10 (Base Station)] FIG.", "7 is a functional block diagram illustrating a main part of RP 10 according to the embodiment of the present invention.", "As illustrated in FIG.", "7, RP 10 according to the present embodiment includes antenna 101, radio reception section 104 receiving a radio signal through antenna 101, reference signal extraction section 12 extracting a DMRS from the received signal, and reception signal processing section 13 removing received data from a data signal using the extracted DMRS.", "RP 10 includes transmission processing section 11 converting transmission data into a signal for radio transmission and radio-transmitting the signal through antenna 101.When terminal apparatus 20 transmits the DMRS of a sequence group allocated to the cell, reference signal extraction section 12 extracts the DMRS of this signal sequence from the radio signal.", "Moreover, when terminal apparatus 20 transmits the DMRS of a sequence group different from that allocated to the cell, reference signal extraction section 12 extracts the DMRS according to this other sequence group from the radio signal.", "How to allocate the other sequence group will be explained below in detail.", "Reception signal processing section 13 performs channel estimation from the extracted DMRS and removes received data from the signal received from terminal apparatus 20 using this channel estimation result.", "FIG.", "8 is a block diagram illustrating the details of RP 10 according to the embodiment of the present invention.", "As illustrated in FIG.", "8, RP 10 specifically includes antenna 101, radio transmission section 102, scheduling information generation section 103, radio reception section 104, CP removal section 105, FFT section 106, demapping section 107, demultiplexing section 108, equalization section 109, inter-RP IF (inter-RP interface) 110, channel estimation section 111, control section 112, IDFT section 113, demodulation section 114, descrambling section 115, decoding section 116, determination section 117, and retransmission control section 118.RP 10 receives a PUSCH data signal transmitted from the terminal and a PUCCH control signal.", "In these sections, CP removal section 105, FFT section 106, demapping section 107, and demultiplexing section 108 function as reference signal extraction section 12 in FIG.", "7.CP removal section 105, FFT section 106, demapping section 107, demultiplexing section 108, equalization section 109, inter-RP IF 110, channel estimation section 111, control section 112, IDFT section 113, demodulation section 114, descrambling section 115, decoding section 116, determination section 117, and retransmission control section 118 function as reception signal processing section 13 in FIG.", "7.Scheduling information generation section 103 and radio transmission section 102 function as transmission processing section 11 in FIG.", "7.Hereinafter, the details of each section will be explained.", "Control section 112 sends information on a base sequence used for a DMRS and information on a scrambling sequence used for scrambling data to channel estimation section 111 and descrambling section 115, respectively.", "Specifically, control section 112 performs the following processes.", "Control section 112 generates a base sequence used for a DMRS multiplexed into the PUSCH data signal transmitted by terminal apparatus 20, and sends the base sequence to channel estimation section 111.Whether a base sequence to be used by terminal apparatus 20 is allocated to a cell or allocated by signaling for an individual terminal is beforehand determined in the network and is indicated to terminal apparatus 20.The network refers to a whole network in which all RPs 10 and a plurality of control apparatuses controlling a communication system are wired-connected.", "This indication may be sent by correspondent RP 10 or may be sent by another RP 10 connected to the network.", "Moreover, this indication may be sent as RRC (Radio Resource Control) control information for an individual terminal, and may be indicated by being included in a MAC (Media Access Control) header.", "Alternatively, this indication may be sent by a control signal transmitted through a downlink (PDCCH).", "In addition, this indication is sent to terminal apparatus 20 only when a base sequence is allocated individually, and the base sequence allocated to the cell may be used when this indication is not sent.", "When the base sequence allocated by signaling for an individual terminal is a sequence determined and indicated by correspondent RP 10, correspondent RP 10 indicates this information to another RP 10 through inter-RP IF 110.On the other hand, when the sequence is determined and indicated by another RP 10, correspondent RP 10 receives this information from the other RP 10 through inter-RP IF 110.Therefore, control section 112 can know the base sequence used by terminal apparatus 20.Control section 112 also generates a scrambling sequence used for scrambling data and sends the scrambling sequence to the descrambling section.", "Whether a scrambling sequence to be used is allocated to a cell or allocated by signaling for an individual terminal is beforehand determined in the network and is indicated to terminal apparatus 20.These determination and indication may be performed by correspondent RP 10 and may be performed by another RP 10 connected to the network.", "Moreover, this indication may be sent as RRC (Radio Resource Control) control information for an individual terminal, and may be included in a MAC header.", "Alternatively, this indication may be sent by a control signal transmitted through a downlink (PDCCH).", "When this indication is not sent particularly, terminal apparatus 20 uses the scrambling sequence allocated to the cell.", "When the scrambling sequence subject to signaling for an individual terminal is a sequence determined and indicated by correspondent RP 10 for terminal apparatus 20, correspondent RP 10 indicates the information to another RP 10 through inter-RP IF 110.On the other hand, when the scrambling sequences is determined and indicated by another RP 10 for terminal apparatus 20, correspondent RP 10 receives the information from the other RP 10 through inter-RP IF 110.Therefore, control section 112 can know the scrambling sequence used for scrambling on data.", "Scheduling information generation section 103 indicates the bandwidth and the frequency position of a PUSCH included in a control signal (PDCCH) to terminal apparatus 20, through radio transmission section 102 and antenna 101.The determination of the bandwidth and the frequency position is called frequency mapping.", "An instruction on frequency mapping may be issued by correspondent RP 10 or may be issued by another RP 10 connected to the network.", "When information on frequency mapping is information determined and indicated by correspondent RP 10 for terminal apparatus 20, scheduling information generation section 103 indicates the information to another RP 10 through inter-RP IF 110.On the other hand, when the information is determined and indicated by another RP 10 for terminal apparatus 20, scheduling information generation section 103 receives the information from the other RP 10 through inter-RP IF 110.Scheduling information generation section 103 sends the above-described information on frequency mapping to demapping section 107.Radio reception section 104 receives a PUSCH data signal transmitted from the terminal, through the antenna, and performs a reception process such as down conversion and A/D conversion.", "CP removal section 105 removes a CP (Cyclic Prefix) added to the DMRS and the data signal of the PUSCH and sends the signal after the elimination to FFT section 106.FFT section 106 applies FFT (Fast Fourier Transform) to the DMRS and the data signal of the PUSCH to convert the signals into frequency domain signals, and then sends the converted signals to demapping section 107.Demapping section 107 demaps the inputted frequency domain PUSCH according to scheduling information.", "Demultiplexing section 108 demultiplexes the DMRS and the data signal, which are time-multiplexed, from the PUSCH signal inputted from demapping section 107, and sends these signals to channel estimation section 111 and equalization section 109, respectively.", "Channel estimation section 111 performs channel estimation using base sequence information inputted from control section 112 and a received DMRS inputted from demultiplexing section 108.Channel estimation section 111 sends a channel estimation result to equalization section 109.Equalization section 109 performs the following processes.", "Specifically, equalization section 109 equalizes the data signal inputted from demultiplexing section 108 using the channel estimation result inputted from channel estimation section 111.This process may be performed independently by each RP 10 participating in the reception.", "Alternatively, this process may be performed by single RP 10 among RPs 10 participating in the reception, by transmitting and receiving the channel estimation results and the data signals, which are acquired by the plurality of RPs 10, through inter-RP IF 110.When each RP 10 participating in the reception performs the equalization independently, equalization section 109 transmits and receives the output of demultiplexing section 108 through inter-RP IF 110, and aggregates the results in one of RPs 10 participating in the reception.", "On the other hand, when single RP 10 among RPs 10 participating in the reception performs the equalization by transmitting and receiving the channel estimation results and the data signals, which are acquired by the plurality of RPs 10, through inter-RP IF 110, equalization section 109 performs the equalization using the plurality of aggregated channel estimation results and the plurality of received data signals.", "In both of the above cases, the equalization output is obtained by equalization section 109 of single RP 10 among RPs 10 participating in the reception.", "Equalization section 109 outputs the signal that has been equalized and outputted, to IDFT section 113.IDFT section 113 converts the equalized frequency domain data signal into a data symbol sequence in a time domain and sends this data symbol sequence to demodulation section 114.Demodulation section 114 performs data demodulation on the input signal, acquires a bit sequence, and outputs the bit sequence to descrambling section 115.Descrambling section 115 descrambles the bit sequence received from demodulation section 114, on the basis of information on a scrambling sequence received from control section 112.The bit sequence after the descrambling process is then outputted to decoding section 116.Decoding section 116 performs error correction decoding on the input bit sequence and outputs the bit sequence after the decoding process to determination section 117.Determination section 117 performs error detection on the inputted bit sequence.", "The error detection is performed using CRC bits added to the bit sequence.", "If the determination result based on the CRC bits has no error, determination section 117 removes received data and indicates ACK (Acknowledgement) to retransmission control section 118.On the other hand, if the determination result based on the CRC bits has an error, determination section 117 indicates NACK (Negative Acknowledgement) to retransmission control section 118.Retransmission control section 118 performs retransmission control on the data signal of the bit sequence including the detected error.", "[Configuration of Terminal Apparatus 20] FIG.", "9 is a functional block diagram illustrating a main part of terminal apparatus 20 according to the embodiment of the present invention.", "As illustrated in FIG.", "9, terminal apparatus 20 according to the present embodiment includes antenna 201, sequence determination section 22 determining a sequence group used for generation of a DMRS, DMRS generation section 203 generating the DMRS using the determined sequence group, and transmission processing section 23 performing radio transmission by generating a signal for radio transmission from transmission data and the generated DMRS.", "Terminal apparatus 20 also includes reception processing section 24 receiving radio signal sent from RP 10 and extracting received data.", "When an instruction to use the sequence group allocated to the cell is issued, sequence determination section 22 determines this sequence group as a sequence group for generating the DMRS.", "On the other hand, when an instruction to use a sequence group which is different from that allocated to the cell is issued, sequence determination section 22 determines this different sequence group as a sequence group for generating the DMRS.", "Hereinafter, a determination method for this different sequence group and an instruction indicating which sequence group to use will be explained in detail.", "DMRS generation section 203 generates a DMRS of a sequence group determined in sequence determination section 22, and sends the DMRS to transmission processing section 23.Transmission processing section 23 maps transmission data and the generated DMRS into a resource block to generate a transmission signal, and transmits this transmission signal by radio through antenna 201.FIG.", "10 is a block diagram illustrating the details of terminal apparatus 20 according to the embodiment of the present invention.", "Specifically, as illustrated in FIG.", "10, terminal apparatus 20 includes antenna 201, control section 202, DMRS generation section 203, encoding section 204, scrambling section 205, modulation section 206, multiplexing section 207, DFT section 208, mapping section 209, IFFT section 210, CP addition section 211, radio transmission section 212, radio reception section 213, and scheduling information extraction section 214.Terminal apparatus 20 transmits a PUSCH data signal and a PUCCH control signal to RP 10.In these sections, control section 202 functions as sequence determination section 22 in FIG.", "9.Control section 202 also includes a functional section (corresponding to a standard sequence determination section) determining a signal sequence to be used for a DMRS from the sequence group allocated to the cell.", "Encoding section 204, scrambling section 205, modulation section 206, multiplexing section 207, DFT section 208, mapping section 209, IFFT section 210, CP addition section 211, and radio transmission section 212 function as transmission processing section 23 in FIG.", "9.Radio reception section 213 and scheduling information extraction section 214 function as reception processing section 24 in FIG.", "9.Next, the details of each section will be explained.", "Control section 202 outputs information on a base sequence used for a DMRS and information on a scrambling sequence used for scrambling on data, to DMRS generation section 203 and scrambling section 205, respectively.", "Specifically, control section 202 performs the following processes.", "Control section 202 outputs a base sequence used for a DMRS to be multiplexed on a PUSCH, to DMRS generation section 203.Whether the base sequence to be used is allocated to the cell or allocated by signaling for an individual terminal is beforehand indicated from the network to terminal apparatus 20.When this indication is not especially sent, terminal apparatus 20 may use the base sequence allocated to the cell.", "Control section 202 generates a scrambling sequence to be used for scrambling on data and outputs the generated scrambling sequence to scrambling section 205.Whether the base sequence to be used is allocated to the cell or allocates by signaling for an individual terminal is beforehand indicated from the network to terminal apparatus 20.In the case of no indication, control section 202 generates the scrambling sequence allocated to the cell.", "Encoding section 204 adds CRC bits to the bit sequence of transmission data inputted from a high layer configuration, performs error correcting coding, and outputs a codeword bit sequence to scrambling section 205.Scrambling section 205 scrambles the code word bit sequence using the scrambling sequence inputted from control section 202.Scrambling section 205 then sends the result from the scrambling to modulation section 206.Modulation section 206 performs data modulation on the inputted bit sequence and sends a data signal after the modulation to multiplexing section 207.Scheduling information extraction section 214 first receives a downlink control signal (PDCCH) through antenna 201 and radio reception section 213, and obtains the bandwidth and the frequency position of a PUSCH indicated from the network.", "The bandwidth and the frequency position are called frequency mapping information.", "Scheduling information extraction section 214 then sends the acquired frequency mapping information to mapping section 209 and DMRS generation section 203.DMRS generation section 203 generates a DMRS having a sequence length corresponding to the bandwidth of the PUSCH inputted from scheduling information extraction section 214 using the base sequence inputted from control section 202, and inputs the generated DMRS to multiplexing section 207.Multiplexing section 207 configures a subframe while time-multiplexing the data signal inputted from modulation section 206 and the DMRS inputted from the DMRS generation section and sends the signal of this subframe to DFT section 208.DFT section 208 applies DFT (Discrete Fourier Transform) to the input signal and acquires a frequency domain signal.", "DFT section 208 sends this frequency domain signal to mapping section 209.Mapping section 209 maps the inputted frequency domain signal according to the frequency mapping information inputted from scheduling information extraction section 214, and sends the mapped signal to IFFT section 210.IFFT section 210 applies IFFT (Inverse Fast Fourier Transform) to the input signal and acquires a time-domain signal, and outputs the acquired time-domain signal to CP addition section 211.CP addition section 211 adds a CP (Cyclic Prefix) to the inputted data signal and DMRS and outputs the resultant signal to radio transmission section 212.Radio transmission section 212 performs transmitting processes such as D/A conversion and up-conversion, and transmits a PUSCH signal to RP 10 through antenna 201.", "[DMRS Transmission-Related Operations] Next, the process flow relating to transmission of a DMRS will be explained with reference to Steps 1 to 5.", "(Step 1) Before transmission and reception of a PUSCH, the network indicates whether a base sequence to be used for a DMRS is allocated to the cell or allocated by signaling for an individual terminal, to terminal apparatus 20.This indication is delivered to control section 202.", "(Step 2) Upon receipt of an instruction to use the base sequence group allocated, control section 202 determines employment of a base sequence group given by expression 1.DMRS generation section 203 then generates the DMRS of this sequence group in response to an instruction from control section 202.When no instruction is particularly issued from the network, a DMRS is generated using the base sequence group given by expression 1.On the other hand, when use of the base sequence allocated by signaling for an individual terminal is indicated, control section 202 determines employment of the base sequence group given by expression 3 described below.", "DMRS generation section 203 then generates the DMRS of this sequence group in response to an instruction from control section 202.", "[3] ũ=(fgh(ns)+{tilde over (f)}ss(ns))mod 30 (Expression 3) In expression 3, fss˜(ns) is a sequence offset amount varying depending on the value of ns (0 to 19) and has the following features.", "[ 4 ] f ~ ss  ( n s ) = ( f ss + F  ( n s ) )  mod   30  { F  ( n s )  mod   30 ≠ 0 Pr  [ F  ( n s ) = x ] ≈ 1 X ( Expression   4 ) X is the total number of elements of a set of the values that can be taken by variable x, and Pr represents the probability to satisfy an expression in the brackets.", "In expression 4, ns represents each time slot in one cycle period (ns=0 to 19) in which sequence groups are allocated repeatedly.", "Hereinafter, the variables and functions with a tilde symbol in expressions are indicated by attaching “˜” to the side of the alphabet symbols.", "Here, F(ns) represents the time variable component of a sequence offset (corresponding to the variable offset).", "Sequence number u˜ to be allocated by signaling for an individual terminal is a value obtained by adding time variable component F(ns) of the variable offset to sequence number u to be allocated to the cell modulo 30 (refer to expression (1) and (3)).", "Therefore, a cell in which sequence number u allocated to the cell overlaps with sequence number u˜ allocated by signaling for an individual terminal is determined by the value of F(ns).", "The first expression of the simultaneous expressions of expression 4 represents a condition on which F(ns) is not equal to zero modulo 30.In other words, this expression represents a condition on which sequence number u˜ allocated by signaling for an individual terminal always does not overlap with sequence number u allocated to the cell including terminal apparatus 20.The second expression of the simultaneous expressions of expression 4 represents that if time variable component F(ns) of the sequence offset takes X different values x (=x1, x2, x3 .", ".", ". )", "during one cycle period (ns=0 to 19), a probability that F(ns) is equal to each value is equal to 1/X.", "In other words, this expression represents a condition that each value (x=x1, x2, x3 .", ".", ". )", "appears equally as the value of F(ns).", "If value x of F(ns) does not take the same value continuously, the same value may be taken around two or three times.", "In other words, in one cell, sequence number u allocated to the cell may discontinuously overlap with sequence number u˜ allocated to terminal apparatus 20 around two or three times during one cycle period.", "This condition can be represented as Pr[F(ns)=x]≤3/X.", "Moreover, it is significantly favorable that time variable component F(ns) of the sequence offset takes values different from one another in one cycle period (ns=0 to 19).", "In other words, it is significantly favorable that sequence number u allocated to each cell in the same cell cluster overlaps with sequence number u˜ allocated by signaling for an individual terminal, and that the cell differs in all time slots ns.", "In this case, the element number of a set of values which x can take is equal to X=20.In addition, it is sufficient that cells corresponding to sequence numbers u and u˜ that overlap with each other are distributed to such a degree that the cells differ at about 50 or more percent in one cycle period (ns=0 to 19).", "This condition can be represented as X≥0.5×20.FIG.", "11 illustrates the situation of interference between the base sequence group given by expressions 3 and 4 and the sequence group allocated to the cell.", "In FIG.", "11, six macro cells having Ncell ID=0 to 5 exist, and a base sequence group given by expressions 3 and 4 is used in a macro cell having Ncell ID=0.In the example of FIG.", "11, the value of Δss in expression 2 is set to 0 in any cell, but may be set to any value.", "These macro cells belong to the same cell cluster and use a common pattern of sequence group hopping.", "In FIG.", "11, an arrow extending from point Pu using a base sequence group given by expressions 3 and 4 indicates that this base sequence group overlaps a base sequence group allocated to a cell (referred to as a cell-specific base sequence group) indicated by the arrow.", "For example, in time slot ns=0, the base sequence group given by expressions 3 and 4 overlaps with the cell-specific base sequence group of the macro cell having Ncell ID=3.Therefore, the influence of interference with a DMRS transmitted and received in this macro cell increases.", "However, in time slot ns=1, the value of sequence offset fss˜(ns) varies, and the base sequence group given by expressions 3 and 4 overlaps with the base sequence group allocated to the macro cell having Ncell ID=1.This base sequence group is different from that of the macro cell having Ncell ID=3 involving the previous overlapping.", "This reduces interference with a DMRS transmitted and received in the macro cell having Ncell ID=3.Similarly, each time slot ns varies as 2, 3, .", ".", ".", ", a cell involving the overlapping changes as the macro cell having Ncell ID=4, the macro cell of Ncell ID=2, .", ".", ".", ".", "(Step 3) Terminal apparatus 20 configures a subframe while time-multiplexing the generated DMRS and data signal generated independently, and maps a PUSCH signal according to frequency mapping information indicated from RP 10.Then, this signal is transmitted to RP 10.", "(Step 4) RP 10 demultiplexes the DMRS and the data signal from the received PUSCH signal.", "Then, RP 10 performs channel estimation using the DMRS.", "(Step 5) RP 10 equalizes a data signal on the basis of the channel estimation result.", "Methods for this equalization include a method of independently performing equalization in the plurality of RPs 10 participating in the reception, and a method of collectively performing equalization by aggregating received signals from the plurality of RPs 10 participating in the reception.", "When each RP 10 independently performing equalization, the equalization result is aggregated in one of RPs 10, and RP 10 involving the aggregation performs demodulation and decode processes on the received data.", "On the other hand, when equalization is performed in an aggregated manner in the plurality of RPs 10 participating in the reception, the channel estimation result and the reception data signal are aggregated in one of RPs 10, and RP 10 involving the aggregation performs equalization and synthesis.", "Then, this RP 10 performs demodulation and decode on the received data.", "As described above, according to the communication system, terminal apparatus 20, and RP 10 in Embodiment 1, terminal apparatus 20 is enabled to use a sequence group different from a sequence group allocated to the cell.", "This can secure many sequence groups that can be used by terminal apparatus 20 in one macro cell.", "Furthermore, a sequence group allocated by signaling for an individual terminal always differs from a sequence group allocated to the macro cell including terminal apparatus 20.Therefore, a DMRS does not interfere with another terminal apparatus 20 using the cell-specific sequence group in the same macro cell.", "Furthermore, a sequence group allocated by signaling for an individual terminal overlaps a sequence group allocated to another macro cell, but this overlapping does not continuously occur in the same macro cell.", "Furthermore, macro cells involving the overlapping are distributed in each time slot in the same cell cluster.", "Therefore, in relatively nearby cells, interference in DMRSs does not occur continuously.", "Therefore, in RPs 10 of each cell, the accuracy of channel estimation does not significantly deteriorate due to interference in DMRSs.", "Furthermore, Embodiment 1 adds offset component F(ns) varying with time to the expression of a sequence group allocated specifically to a cell, and determines a sequence group allocated by individual signaling for terminal apparatus 20.Therefore, if this F(ns) is regular, the hopping pattern of a sequence group used by terminal apparatus 20 is not the same as or similar to the hopping pattern of another cell cluster.", "Therefore, in respective cells of another relatively distant cell clusters, any one cell does not tend to have overlapping sequence groups.", "That is, in cells of the other cell cluster, even if a cell has sequence groups overlapping continuously, such overlapping does not occur for a long period.", "Therefore, also in each RP 10 of the other cell cluster, the accuracy of channel estimation does not significantly deteriorate due to interference in DMRSs.", "Moreover, existing base sequence group can be reused in order to secure many sequence groups that can be used by terminal apparatus 20 in one macro cell in Embodiment 1, and it is not necessary to define a new base sequence group or a new hopping pattern.", "Moreover, a sequence group allocated by signaling for an individual terminal can be determined only by adding one parameter F(ns) to the determination expression of a sequence group allocated specifically to a cell.", "Therefore, the circuit size for determining these sequence groups does not increase.", "Embodiment 2 In a communication system according to Embodiment 2, only the allocation pattern of the base sequence group performed by signaling for an individual terminal differs from Embodiment 1.Therefore, only different points will be explained in detail.", "A base sequence group allocated by signaling for an individual terminal in Embodiment 2 is characterized by sequence offset fss˜(ns) of expression 5 described below.", "Number u˜ of the base sequence group allocated by signaling for an individual terminal is determined by expression 3.", "[5] {tilde over (f)}ss(ns)=(fss+λ·ns+z)mod 30 (Expression 5) In expression 5, λ and z are integers that are not equal to 0.FIG.", "12 illustrates allocation patterns of base sequence groups in λ=1 and z=1.In this example, similarly to the case of FIG.", "11, assuming that some terminal apparatuses 20 in the macro cell having Ncell ID=0 use a base sequence group determined by expression 5.In this case, a base sequence group allocated to these terminal apparatuses 20 overlaps with a base sequence group allocated to the macro cell having Ncell ID=1 in time slot ns=0.The base sequence group overlaps with a base sequence group allocated to the macro cell having Ncell ID=2 in time slot ns=1.Similarly, base sequence groups allocated to the terminal apparatus 20 in time slots ns=2 to 19 sequentially overlap with each of the base sequence groups allocated to the macro cells having Ncell ID=3 to 20 once.", "On the other hand, base sequence groups allocated to terminal apparatus 20 do not overlap with base sequence groups allocated to the cells having Ncell ID=0 and Ncell ID=21 to 29 once.", "Attention is focused on the case where a base sequence group is allocated to terminal apparatus 20 in the macro cell having Ncell ID=1 on the basis of expression 5.In this case, the sequence group overlaps with a base sequence group allocated to the cell having Ncell ID=2 in time slot ns=0, and overlaps with a base sequence group allocated to the cell having Ncell ID=3 in time slot ns=1.Subsequent overlapping of the sequence group similarly occurs in each of the plurality of cells until ns=19 once.", "Here, sequence groups allocated by signaling for an individual terminal are compared between the macro cell having Ncell ID=0 and the macro cell having Ncell ID=1.As a result, these sequence groups are always different from each other in each time slot ns.", "As described above, it is found that overlapping always does not occur between base sequence groups individually allocated to respective terminal apparatuses 20 connected to different cells belonging to the same cell cluster.", "FIG.", "13 illustrates allocation patterns of base sequence groups in the case of varying parameter z.", "FIG.", "14 illustrates allocation patterns of base sequence groups in the case of varying parameter λ. FIGS.", "13 and 14 illustrate that a base sequence group of each cell overlapping with an arrow line overlaps with a base sequence group allocated by signaling for an individual terminal in each time slot.", "As illustrated in FIGS.", "13 and 14, variations in parameters λ and z cause variations in allocation patterns of base sequence groups by signaling for an individual terminal.", "As illustrated in FIG.", "13, a variation in parameter z cause variations in the allocation patterns so that a cell and time slot ns which involve overlapping of base sequence groups may be shifted by a number proportional to parameter z.", "As illustrated in FIG.", "14, a variation in parameter λ may also cause, for example, such a variation that base sequence groups overlap twice in a cell.", "As described above, according to the communication system, terminal apparatus 20, and RP 10 in Embodiment 2, the same advantageous effects as Embodiment 1 can be acquired only by adding a time variable component of a simple linear function to a sequence offset.", "Furthermore, according to Embodiment 2, parameter z and parameter λ are suitably selected to thereby enable constant prevention of overlapping between respective sequence groups allocated by signaling for an individual terminal in a plurality of cells belonging to the same cell cluster.", "Therefore, interference in DMRSs does not occur between the plurality of terminal apparatuses 20 included in each of a plurality of cells subject to this allocation.", "Moreover, suitable selection of parameter z and parameter λ for each cell also enables such configuration that the above-described sequence groups overlap only at a predetermined ratio.", "Embodiment 2 has been described using an example configuration based on adding a linear function of time slot ns to sequence offset fss.", "However, as long as the conditions of expression 4 is satisfied, Embodiment 2 may be provided by applying a configuration based on adding a polynomial, such as a quadratic function of time slot ns, or various functions to sequence offset fss.", "Moreover, Embodiment 2 has been described using an example configuration based on finding sequence offset fss˜(ns) including a time variable component through a calculation process.", "However, an alternative configuration may also be employed in which such sequence offset fss˜(ns) is stored in a storing section, for example, as a data table, and then control section 202 reads and finds the sequence offset from the storing section.", "An example of a data table storing sequence offset fss˜(ns) will be illustrated below.", "TABLE 1 ns {tilde over (f)}ss (ns) 0 fss + 10 1 fss + 5 2 fss + 8 3 fss + 2 4 fss + 9 5 fss + 1 .", ".", ".", ".", ".", ".", "19 fss + 6 The configuration in which to store sequence offset fss˜(ns) including a time variable component can be employed as described above to thereby represent even a sequence offset including a time variable component that cannot be represented by a simple function easily.", "Moreover, sequence offsets do not need to be found through calculation, and therefore a necessary calculation circuit can be reduced.", "Embodiment 3 In a communication system according to Embodiment 3, the allocation pattern of a base sequence group by signaling for an individual terminal is applicable to an OCC multiplex transmission scheme for a DMRS, and the configuration other than that is the same as that of Embodiment 1.Therefore, only different points will be explained in detail.", "In a PUSCH, two DMRSs located in a subframe are multiplied by [+1, +1] or [+1, −1] as an orthogonal cover code (OCC) to thereby enable two different terminal apparatuses 20 to code-multiplex and transmit the DMRSs of the same sequence.", "However, in this transmission scheme, each terminal apparatus 20 needs to use a DMRS of the same sequence in two time slots of a subframe.", "Incidentally, Rel.", "10 of LTE-A includes a mechanism for stopping the hopping of a base sequence group by a terminal-specific RRC control signal, and can stop the hopping to thereby employ DMRS transmission using OCC multiplex.", "FIG.", "15 is an explanatory diagram illustrating sequence groups allocated by signaling for an individual terminal in Embodiment 3.As illustrated in FIG.", "15, sequence groups allocated by signaling for an individual terminal in Embodiment 3 employ configurations in which a base sequence group is allocated by adding sequence offsets of expressions different between an odd time slot (ns mod 2=1) and an even time slot (ns mod 2=0).", "Consequently, Embodiment 3 allocates the same sequence number to an odd time slot (ns mod 2=1) and an even time slot (ns mod 2=0).", "Specifically, such allocation can be implemented as follows.", "That is, a configuration adding sequence offsets of expression 6 described below in an odd time slot and an even time slot and obtaining sequence numbers can be employed.", "[6] In a time slot satisfying (ns mod 2)=0, {tilde over (f)}ss(ns)=(fss+λ·ns/2+z)mod 30 In a time slot satisfying (ns mod 2)=1, {tilde over (f)}ss(ns)={tilde over (f)}ss(ns−1) (Expression 6) As a specific example of this, FIG.", "15 illustrates base sequence group hopping patterns in λ=1 and z=1.As illustrated in FIG.", "15, it is found that base sequence groups are the same in two time slots in a subframe.", "According to the communication system of Embodiment 3, base sequence groups allocated by signaling for an individual terminal can be used for transmission of DMRSs using an OCC multiplex in two terminal apparatuses 20.Moreover, a base sequence group allocated to the cell has a sequence varying in units of slots.", "Therefore, a sequence group allocated by signaling for an individual terminal does not continuously overlap with a sequence group allocated to the cell in the same macro cell.", "Therefore, a method for allocating a base sequence group in Embodiment 3 can also reduce interference from a DMRS of terminal apparatus 20 having a sequence group allocated by signaling for an individual terminal with a DMRS of terminal apparatus 20 to which a cell-specific sequence group is applied, similarly to Embodiment 1 and Embodiment 2.In Embodiment 3, an alternative configuration can also be employed in which sequence offset fss˜(ns) including a time variable component is stored in a storing section as a data table and then is read and found from the storing section.", "An example of a data table storing sequence offset fss˜(ns) in Embodiment 3 will be illustrated below.", "TABLE 2 ns {tilde over (f)}ss (ns) 0 fss + 10 1 fss + 10 2 fss + 2 3 fss + 2 4 fss + 4 5 fss + 4 .", ".", ".", ".", ".", ".", "19 fss + 6 The configuration in which to store sequence offset fss˜(ns) including a time variable component can be employed as described above to thereby represent the same sequence offsets in two continuous time slots easily.", "Furthermore, the configuration can easily represent even a sequence offset including a time variable component that cannot be represented by a simple function.", "Moreover, sequence offsets do not need to be found through calculation, and therefore a necessary calculation circuit can be reduced.", "In addition, Embodiment 3 may switch whether hopping of a base sequence group allocated for an individual terminal has a pattern varying for each time slot or a pattern varying for each subframe, according to a next control parameter.", "In Rel.", "10 of LTE-A, signaling of the high-order layer aiming at performing DMRS multiplex by an OCC has already been regulated.", "This signaling is performed using control parameters of “dmrs-WithOCC-Activated” or “groupHoppingDisabled” indicated for an individual terminal by RRC control information.", "Therefore, when a base sequence group is allocated by terminal-specific signaling in Embodiment 3, one of the control parameters, i.e., “dmrs-WithOCC-Activated” and “groupHoppingDisabled” can be used.", "When one of the control parameters, i.e., “dmrs-WithOCC-Activated” and “groupHoppingDisabled” is “True”, terminal apparatus 20 employs a hopping pattern varying for each subframe using a sequence offset from expression 6 or Table 1, and generates a DMRS subject to OCC multiplex.", "On the other hand, when one of the control parameters, i.e., “dmrs-WithOCC-Activated” and “groupHoppingDisabled” is “False”, terminal apparatus 20 employs a hopping pattern varying for each time slot using a sequence offset described in Embodiment 2, and generates a DMRS.", "Such a configuration can transmit a DMRS subject to OCC multiplex between terminals using base sequence groups allocated by terminal-specific signaling without adding new signaling.", "Embodiment 4 In configurations of a communication system, terminal apparatus 20, and RP 10 according to Embodiment 4, a network determines the allocation pattern of a base sequence group performed by signaling for an individual terminal, and indicates the allocation pattern to terminal apparatus 20.The configurations other than that are the same as those of Embodiment 2.Hereinafter, different points will be explained in detail.", "[Outline of Communication System] The communication system in Embodiment 4 includes including one or more RPs 10 in a macro cell and terminal apparatus 20 similarly to Embodiment 1.In the communication system of Embodiment 4, the network beforehand determines parameters “λ, z” in Expression 5 or 6 representing a base sequence group allocated by signaling for an individual terminal.", "[Configuration of RP 10] Control section 112 of RP 10 outputs parameters “λ, z” to channel estimation section 111.Parameters “λ, z” are beforehand determined in the network and are indicated to RP 10 through inter-RP IF 110.Correspondent RP 10 may determine parameters “λ, z.” When correspondent RP 10 determines the parameters, the information is indicated to another RP 10 through inter-RP IF 110.On the other hand, when another RP 10 determines the parameters, correspondent RP 10 receives the information from the other RP 10 through inter-RP IF 110.", "[Configuration of Terminal Apparatus 20] Control section 202 of terminal apparatus 20 inputs parameters “λ, z” into DMRS generation section 203.Parameters “λ, z” are beforehand determined in the network and are indicated to terminal apparatus 20.This indication may be sent as RRC control information for an individual terminal and may be included in a MAC header.", "Alternatively, this indication may be sent by a control signal transmitted through a downlink (PDCCH).", "When this indication is not especially sent, both parameters “λ, z” are set to “0” (equivalent to using the base sequence group allocated to the cell).", "[DMRS Transmission-Related Operations] In the communication system of Embodiment 4, when new parameters “λ, z” are indicated from the network to terminal apparatus 20, control section 202 of terminal apparatus 20 overwrites parameter “λ, z” in expression 5 (or expression 6).", "Moreover, when indicating new parameters “λ, z” to terminal apparatus 20, the network indicates parameters “λ, z” to control section 112 of each RP 10 participating in the reception, and control section 112 of RP 10 overwrites parameters “λ, z” in expression 5 (or expression 6).", "Other process flows relating to transmission of DMRSs performed by RP 10 and terminal apparatus 20 are the same as those in Embodiment 1.According to the communication system, RP 10, and terminal apparatus 20 in Embodiment 4, the network can appropriately select parameters “λ, z” according to the placement of the cells to thereby set sequence groups suitable for the placement of the cells.", "Specifically, the network enable a control so as to determine a sequence group allocated by signaling for an individual terminal in terminal apparatus 20 so that overlapping of sequence groups does not occur in other nearby cells tending to involve large influence of interference.", "Instead of a configuration indication parameter information that can represent all the values and combination that can be taken as parameters “λ, z,” the network or RP 10 may also have a configuration indication parameter information that has a small bit length and can represent only some of the combinations of parameters “λ, z.” This configuration can reduce the number of transmission bits required for the indication of parameters “λ, z”.", "Alternatively, a configuration may be used in which a region of nine or more bits of established control data is defined as an indication region for terminal-specific signaling, and the information on this indication region is used to determine a base sequence group used for generation of a DMRS by terminal apparatus 20.Specifically, when a value (for example, 0 to 503 in the case of nine bits) representing a cell ID is indicated in the indication region, terminal apparatus 20 generates a DMRS using a base sequence group obtained by rewriting Ncell ID in expressions 1 and 2 with a value corresponding to the information in the indication region.", "Moreover, when a value not representing a cell ID is indicated in the indication region, a DMRS is generated using a base sequence group given by expression 3 (for example, expressions 5 and 6).", "This configuration may also be used.", "Also in such a configuration, when information in the indication region is not indicated, terminal apparatus 20 can generate a DMRS using a base sequence group allocated to the cell.", "This configuration can select a base sequence group used for generation of a DMRS by terminal apparatus 20, according to the value of the indication information.", "That is, a base sequence group to be used can be selected from a base sequence group allocated a connected cell, a base sequence group allocated to an unconnected cell, and a base sequence group allocated for an individual terminal.", "Furthermore, a configuration may be employed in which parameters “λ, z” are associated with values representing information other than a cell ID in the indication region, and are indicated to terminal apparatus 20 using the value representing information other than a cell ID.", "Specifically, values representing information other than a cell ID (for example, 504 to 511 in the case of nine bits) in the indication region are associated with eight combinations of parameters “λ, z,” and when this value is indicated, control section 202 of terminal apparatus 20 overwrites parameters “λ, z” in expression 5 (or Expression 6).", "Terminal apparatus 20 then generates and transmits a DMRS using a sequence group determined by expression 5 (or expression 6) after the overwriting.", "This configuration enable the network to select parameters “λ, z” suitable for the cell placement and to indicate the parameters to terminal apparatus 20, without adding a new indication bit.", "The indication region has nine or more bits in the above explanation of the configuration, but can also have less than nine bits.", "When a cell-specific base sequence group of another cell is allocated as a base sequence group allocated by signaling for an individual terminal, allocating the same base sequence group as that of a nearby cell should be avoided in order to suppress influence of the interference.", "Especially, influence of the interference may be increased by allocating a base sequence group of another cell in the same cell cluster for an individual terminal.", "Therefore, the number of base sequence groups allocated to other cells that can be used as terminal-specific base sequence groups in reality is smaller than the number of all the cell IDs of “504.” Therefore, the cell ID of a cell-specific base sequence group that can be allocated can be indicated with the number of indication bits smaller than nine.", "For example, the offset for the cell ID of a connected cell can be indicated with the number of indication bits smaller than nine, and the cell ID of another cell can be indicated.", "This configuration can reduce the number of bits of indication information.", "Embodiment 5 Hereinafter, other examples will be explained on a determination method for a base sequence group allocated by signaling for an individual terminal.", "In Embodiments 1 to 4, sequence offset fss˜ is represented by a function of time slot ns.", "In contrast to this, in Embodiment 5, sequence offset fss is a fixed value, and PN hopping pattern fgh˜ is represented as a function of time slot ns.", "Specifically, Embodiment 5 determines sequence number u˜ using expression 7.", "[7] ũ=({tilde over (f)}gh(ns)+fss)mod 30 (Expression 7) In expression 7, {tilde over (f)}gh(ns) is a sequence group hopping pattern determined by a PN sequence having an initial value equal to └Ncell ID/30┘+G(ns), and G(ns) is a function satisfying a condition of Expression 8 described below.", "A symbol └ ┘ refers to truncation after the decimal point.", "[ 8 ] { G  ( n s )  mod   30 ≠ 0 Pr  [ G  ( n s ) = y ] ≈ 1 Y ( Expression   8 ) Here, Y is the total number of values that can be taken by variable y.", "When sequence number u˜ overlaps with a base sequence group allocated to the connected cell in expression 7, a different value is substituted into sequence number u˜.", "Alternatively, fgh˜(ns) may be given as values stored as a data table in a storing section instead of a function.", "According to this determination method for a base sequence group, hopping of the sequence group is enabled using new hopping pattern different from all cell clusters, without significantly changing the determination expression for a base sequence group given by expressions 1 and 2.Alternatively, sequence offset fss˜(ns) including a time variable component described in Embodiments 1 to 4 may be added to hopping pattern fgh˜(ns) given by the above-described function of time slot ns to thereby determine sequence number u˜.", "Moreover, both the PN hopping pattern and the sequence offset represented by functions of time slot ns may also be provided as a data table.", "Embodiment 6 Embodiment 6 solves a problem of securing a large number of base sequence groups that can be used by terminal apparatus 20 in a connected cell when the influence of interference with another cell is not significantly large.", "FIG.", "16 illustrates a sequence group allocated by signaling for an individual terminal in Embodiment 6.In Embodiment 6, expressions 1 and 2 determining a cell-specific base sequence group are used to change the value of Ncell ID in the expressions into the value (constant value) of new parameter K and to determine a sequence group allocated by signaling for an individual terminal.", "The value of new parameter K is set as Ncell ID of a cell other than the connected cell in the same cell cluster.", "FIG.", "16 illustrates an example case where new parameter K is set as the value “K=3” of the cell ID of another cell (Ncell ID=3) in the same cell cluster when terminal apparatus 20 is located in the connected cell (Ncell ID=0).", "In this case, a base sequence group allocated by signaling for an individual terminal is the same as a cell-specific base sequence group of other cell (Ncell ID=3), but does not overlap with a cell-specific base sequence group of any other cell in the same cell cluster once.", "According to the communication system of Embodiment 6, a large number of base sequence groups that can be used in one cell can be secured by allocating a base sequence group by signaling for an individual terminal using new parameter K. This configuration is useful when the influence of interference with another cell is not large, for example, when a few other terminal apparatuses 20 are connected to another cell (Ncell ID=3).", "In addition, new parameter K may also be determined in a network and may be indicated from RP 10 to terminal apparatus 20.Embodiment 7 Embodiment 7 solves a problem of securing a large number of base sequence groups that can be used by terminal apparatus 20 in a connected cell when the influence of interference with a cell in another cell cluster is not significantly large.", "FIG.", "17 illustrates a sequence group allocated by signaling for an individual terminal in Embodiment 7.In Embodiment 7, expressions 1 and 2 determining a cell-specific base sequence group are used to change the value of Ncell ID in the expressions into the value (constant value) of new parameter K and to determine a sequence group allocated by signaling for an individual terminal.", "The value of new parameter K is set as Ncell ID of a cell in another cell cluster.", "FIG.", "17 illustrates an example case where new parameter K is set as the value “K=30” of the cell ID of a cell (Ncell ID=30) in another cell cluster when terminal apparatus 20 is located in the connected cell (Ncell ID=0).", "In this case, a base sequence group allocated by signaling for an individual terminal always overlaps with a cell-specific base sequence group of one cell in the other cell cluster, but randomly overlaps with a cell-specific base sequence group of each cell in the same cell cluster.", "According to the communication system of Embodiment 7, a large number of base sequence groups that can be used in one cell can be secured by allocating a base sequence group by signaling for an individual terminal using new parameter K. This configuration is useful when it is known that the influence of interference with a specific cell in another cell cluster hardly occurs, for example, when a specific cell in another cell cluster is significantly distant.", "In addition, new parameter K may also be determined in a network and may be indicated from RP 10 to terminal apparatus 20.In the above, each embodiment of the present invention has been explained.", "In each above-described embodiment, a specific example of a base sequence group allocated by signaling for an individual terminal has been explained.", "However, the present invention is not limited to the expressions or the data tables illustrated in each embodiment.", "The present invention includes all allocation patterns of sequence groups satisfying the following conditions 1 to 3.1.The base sequence group is always different from a base sequence group allocated to a connected cell of a terminal apparatus.", "2.The sequence group has a hopping pattern different from that of a base sequence group allocated to a cell belonging to another cell cluster.", "3.Overlapping with a base sequence group allocated to another cell in the same cell cluster does not concentrate in a single cell.", "Although the above-described embodiments have been explained using a DMRS as a target reference signal, an SRS or other reference signals can also be used as a target reference signal.", "Moreover, the antenna explained in the above-described embodiments can be replaced with an antenna port.", "Although each above-described embodiment has been explained using a case where the present invention is implemented with hardware, as an example, the present invention can be implemented with software in cooperation with hardware.", "Furthermore, each function block employed in the explanation of each above-described embodiment may typically be implemented as an LSI constituted by an integrated circuit.", "These function blocks may be individual chips or partially or totally contained on a single chip.", "The term “LSI” is adopted herein but this may also be referred to as “IC,” “system LSI,” “super LSI,” or “ultra LSI,” depending on the differing extents of integration.", "The method of implementing integrated circuit is not limited to LSI, and implementation by means of dedicated circuitry or a general-purpose processor may also be possible.", "After LSI manufacture, utilization of a field programmable gate array (FPGA) or a reconfigurable processor where connections and settings of circuit cells in an LSI can be reconfigured is also possible.", "If a new integrated circuit implementation technology replacing LSI is introduced because of advancement in semiconductor technology or a different technology derived therefrom, the function blocks may of course be integrated using that technology.", "For example, application of biotechnology is possible.", "The disclosure of Japanese Patent Application No.", "2012-016414, filed on Jan. 30, 2012, including the specification, drawings and abstract, is incorporated herein by reference in its entirety.", "INDUSTRIAL APPLICABILITY The present invention is applicable to a cellular portable telephone, a base station therefor, and a communication method therefor.", "The various embodiments described above can be combined to provide further embodiments.", "All of the U.S. patents, U.S. patent application publications, U.S. patent applications, foreign patents, foreign patent applications and non-patent publications referred to in this specification and/or listed in the Application Data Sheet are incorporated herein by reference, in their entirety.", "Aspects of the embodiments can be modified, if necessary to employ concepts of the various patents, applications and publications to provide yet further embodiments.", "These and other changes can be made to the embodiments in light of the above-detailed description.", "In general, in the following claims, the terms used should not be construed to limit the claims to the specific embodiments disclosed in the specification and the claims, but should be construed to include all possible embodiments along with the full scope of equivalents to which such claims are entitled.", "Accordingly, the claims are not limited by the disclosure.", "REFERENCE SIGNS LIST 10 RP (Base station) 11 Transmission processing section 12 Reference signal extraction section 13 Reception signal processing section 101 Antenna 102 Radio transmission section 104 Radio reception section 111 Channel estimation section 112 Control section 20 Terminal apparatus 22 Sequence determination section 23 Transmission processing section 24 Reception processing section 201 Antenna 202 Control section 203 DMRS generation section 212 Radio transmission section 213 Radio reception section" ] ]
Patent_15874201
[ [ "CUT-RESISTANT FABRIC, ARTICLES", "Provided among other things is a cut-resistant article comprising: a cut-resistant synthetic fabric; and adherent to the fabric a layer of polyurethane polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 16, wherein the article has a cut resistance by ISO 13997:1999 of 2 or higher." ], [ "1.A cut-resistant article comprising: a fabric; and adherent to the fabric a layer of polyurethane polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 16, wherein the article has a cut resistance by EN388 of 2 or higher.", "2.The cut-resistant article of claim 1, wherein the particles have average D mass weighted from about 5 to about 23 micron.", "3.The cut-resistant article of claim 2, wherein the particles have average L mass weighted from about 100 to about 210 micron.", "4.The cut-resistant article of claim 2, wherein the particles have average L mass weighted from about 100 to about 170 micron.", "5.The cut-resistant article of claim 2, wherein the particles have hardness of about 5 Mohs or higher.", "6.The cut-resistant article of claim 1, wherein the particles have hardness of about 5 Mohs or higher.", "7.The cut-resistant article of claim 1, wherein the fabric is a cut-resistant synthetic fabric.", "8.A cut-resistant article comprising: a cut-resistant synthetic fabric that is a 70% or more polyamide; and adherent to the fabric a layer of polyurethane polymer comprising about 5% or more polyurethane and about 60% or more nitrile in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27, wherein the article has a cut resistance by EN388 of 2 or higher, and wherein the polymer is adhered to the fabric by coagulation-mediated dip coating onto the fabric, and subsequent curing.", "9.The cut-resistant article of claim 8, wherein the particles have average D mass weighted from about 5 to about 23 micron.", "10.The cut-resistant article of claim 9, wherein the particles have average L mass weighted from about 100 to about 210 micron.", "11.The cut-resistant article of claim 9, wherein the particles have average L mass weighted from about 100 to about 170 micron.", "12.The cut-resistant article of claim 9, wherein the particles have hardness of about 5 Mohs or higher.", "13.The cut-resistant article of claim 8, wherein the particles have hardness of about 5 Mohs or higher.", "14.A method of forming a cut-resistant article comprising: applying a coagulant to a fabric; coagulating on the fabric a layer of polyurethane polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27; curing the coagulated polymer; and obtaining the article, which has a cut resistance by EN388 of 2 or higher.", "15.The method of claim 14, wherein the particles have average D mass weighted from about 5 to about 23 micron.", "16.The method of claim 14, wherein the particles have average L mass weighted from about 100 to about 210 micron.", "17.The method of claim 16, wherein the particles have hardness of about 5 Mohs or higher.", "18.The method of claim 14, wherein the fabric is a cut-resistant synthetic fabric.", "19.A cut-resistant article comprising: a fabric; and adherent to the fabric a layer of polyurethane polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27, wherein the article has a cut resistance by EN388 of 2 or higher, wherein the article has one or more features indicative of layer of polymer being applied by a process wherein coagulant is applied to the cut-resistant synthetic fabric to coagulate a coagulation-sensitive dispersion of polymer to form the layer of polymer.", "20.The cut-resistant article of claim 19, wherein the particles have average D mass weighted from about 5 to about 23 micron." ], [ "<SOH> SUMMARY <EOH>Provided in one embodiment is a cut-resistant article comprising: a fabric (including a cut-resistant fabric or a non-cut-resistant fabric); and adherent to the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 16, wherein the article has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher, or 5 or higher.", "The fabric can be of synthetic, semi-synthetic (e.g., polycotton), or natural fiber.", "The fabric can be shaped as an article, such as a glove, and as an article can be seamless or seamed.", "Provided in a further embodiment is a cut-resistant article comprising: a synthetic cut-resistant fabric (including a semi-synthetic fabric); and adherent to the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 16, wherein the article has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher, or 5 or higher.", "The fabric can be of synthetic, semi-synthetic, or natural fiber.", "Provided in another embodiment is a cut-resistant article comprising: (a) a cut-resistant synthetic fabric that is a 70% or more polyamide; and (b) adherent to the fabric a layer of polymer comprising about 5% or more polyurethane and about 60% or more nitrile in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27, wherein the article has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, 4 or higher, and wherein the polymer is adhered to the fabric by coagulation-mediated dip coating onto the fabric, and subsequent curing.", "Provided in a further embodiment is a method of forming a cut-resistant article comprising: (1) applying a coagulant to a fabric; (2) coagulating on the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27; (3) curing the coagulated polymer; and (4) obtaining the article, which has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher.", "Provided in a further embodiment is a method of forming a cut-resistant article comprising: (1) applying a coagulant to a cut-resistant synthetic fabric; (2) coagulating on the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27; (3) curing the coagulated polymer; and (4) obtaining the article, which has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher.", "Provided in another embodiment is a cut-resistant article comprising: (A) a fabric; and (B) adherent to the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27, wherein the article has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher, or 5 or higher, wherein the article has one or more features indicative of layer of polymer being applied by a process wherein coagulant is applied to the fabric to coagulate a coagulation-sensitive dispersion of polymer to form the layer of polymer.", "Provided in another embodiment is a cut-resistant article comprising: (A) a cut-resistant synthetic fabric; and (B) adherent to the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27, wherein the article has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher, or 5 or higher, wherein the article has one or more features indicative of layer of polymer being applied by a process wherein coagulant is applied to the cut-resistant synthetic fabric to coagulate a coagulation-sensitive dispersion of polymer to form the layer of polymer." ], [ "The present application relates generally to cut-resistant polymer-coated fabrics that incorporate mineral fibers in the polymer coating.", "The current application is a continuation-in-part of U.S. Ser.", "No.", "14/933,122, filed Nov. 5, 2015, and claims benefit of U.S. Ser.", "No.", "62/131,315, filed Mar.", "11, 2015, U.S. Ser.", "No.", "62/083,636, filed Nov. 24, 2014, and U.S. Ser.", "No.", "62/075,597, filed Nov. 5, 2014, the contents of each of which are incorporated herein in their entireties.", "Henssen et al., U.S. Pat.", "Publ.", "2013/0125283, describes articles having mineral fibers in a polymer coating where the fibers are said to have a range of L/D ratios.", "The Hessen application however only experimentally illustrates these articles with mineral fibers having an L/D ratio of 25.6.Nothing in Henssen discloses or suggests that using an L/D ratio of 5 to 16 (by the L/D measurement method set forth in Example 1 of Henssen) would have remarkably greater cut resistance than using a similar mineral fiber with L/D ratio of 17.9.Neither does Henssen disclose or suggest that polyurethane/nitrile coated cut resistant polyamide fabric would have the cut resistance described herein.", "SUMMARY Provided in one embodiment is a cut-resistant article comprising: a fabric (including a cut-resistant fabric or a non-cut-resistant fabric); and adherent to the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 16, wherein the article has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher, or 5 or higher.", "The fabric can be of synthetic, semi-synthetic (e.g., polycotton), or natural fiber.", "The fabric can be shaped as an article, such as a glove, and as an article can be seamless or seamed.", "Provided in a further embodiment is a cut-resistant article comprising: a synthetic cut-resistant fabric (including a semi-synthetic fabric); and adherent to the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 16, wherein the article has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher, or 5 or higher.", "The fabric can be of synthetic, semi-synthetic, or natural fiber.", "Provided in another embodiment is a cut-resistant article comprising: (a) a cut-resistant synthetic fabric that is a 70% or more polyamide; and (b) adherent to the fabric a layer of polymer comprising about 5% or more polyurethane and about 60% or more nitrile in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27, wherein the article has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, 4 or higher, and wherein the polymer is adhered to the fabric by coagulation-mediated dip coating onto the fabric, and subsequent curing.", "Provided in a further embodiment is a method of forming a cut-resistant article comprising: (1) applying a coagulant to a fabric; (2) coagulating on the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27; (3) curing the coagulated polymer; and (4) obtaining the article, which has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher.", "Provided in a further embodiment is a method of forming a cut-resistant article comprising: (1) applying a coagulant to a cut-resistant synthetic fabric; (2) coagulating on the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27; (3) curing the coagulated polymer; and (4) obtaining the article, which has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher.", "Provided in another embodiment is a cut-resistant article comprising: (A) a fabric; and (B) adherent to the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27, wherein the article has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher, or 5 or higher, wherein the article has one or more features indicative of layer of polymer being applied by a process wherein coagulant is applied to the fabric to coagulate a coagulation-sensitive dispersion of polymer to form the layer of polymer.", "Provided in another embodiment is a cut-resistant article comprising: (A) a cut-resistant synthetic fabric; and (B) adherent to the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27, wherein the article has a cut resistance by ISO 13997:1999 (or EN388) of 2 or higher, or 3 or higher, or 4 or higher, or 5 or higher, wherein the article has one or more features indicative of layer of polymer being applied by a process wherein coagulant is applied to the cut-resistant synthetic fabric to coagulate a coagulation-sensitive dispersion of polymer to form the layer of polymer.", "DESCRIPTION OF THE DRAWINGS So that the manner in which the above recited features of the present invention can be understood in detail, a more particular description of the invention, briefly summarized above, may be had by reference to embodiments, some of which are illustrated in the appended drawings.", "It is to be noted, however, that the appended drawings illustrate only illustrative embodiments of this invention and are therefore not to be considered limiting of its scope, for the invention may admit to other equally effective embodiments.", "FIG.", "1 depicts schematically a portion of an article of the invention in cross-section; FIG.", "2 is an illustrative manufacturing procedure; FIG.", "3 shows the cut-resistance results for a number of articles according to the invention; and FIGS.", "4A and 4B show the cut-resistance results for an article according to the invention.", "To facilitate understanding, identical reference numerals have been used, where possible, to designate comparable elements that are common to the figures.", "The figures are not drawn to scale and may be simplified for clarity.", "It is contemplated that elements and features of one embodiment may be beneficially incorporated in other embodiments without further recitation.", "DETAILED DESCRIPTION FIG.", "1 depicts schematically a fabric 10 coated with a polymer layer 20 in which are dispersed fibers 22.The cut-resistant articles of the invention are formed on fabric supports, such as fabric glove liners.", "The fabric can be, for example, knitted, woven or non-woven, and/or seamless or cut and sewn.", "The fabric can comprise for example about 70, 80 or 85% or more cut-resistant yarns (by wt).", "Cut resistant yarns comprise, for example, ultra high molecular weight polyethylene (UHMWPE), such as DYNEEMA®, TSUNOOGA®, a meta-aramid, such as NOMEX®, or a para-aramid, such as KEVLAR® or TWARON® (meta and para-aramids being cut-resistant polyamides).", "Elastic yarns, such as LYCRA®, SPANDEX®, or ELASTANE® may be used to impart flexibility.", "In embodiments, the fabric includes (e.g., about 70, 80 or 85% or more by wt) polycarbonate or glass fibers (including without limitation glass fiber yarn fabric).", "In embodiments, the fabric comprises about 70, 80 or 85% or more of a polyamide cut-resistant yarn.", "In embodiments, the fabric is about 98% or more, or about 100% cut-resistant yarn, such as cut-resistant polyamide yarn.", "In other embodiments, the fabric is cotton, polycotton, polyester, polypropylene, or the like, or mixtures thereof.", "To produce the article, typically the fabric is fitted on a former, namely a solid support shaped to support the contours of the final shape of the article.", "The fitting can be such that the fabric is stretched somewhat over the final sizing.", "Typically, the article is dipped into or has applied to it a coagulant composition, such as one containing calcium nitrate, calcium sulfate, acetic acid or another coagulant.", "Typically, the coagulant composition on the fabric is dried to remove solvent.", "Then, the fabric on the former is dipped into, or otherwise has applied to it, an elastomer composition formulated to coagulate on contact with the coagulant.", "Additional coatings may be applied, with or without intervening coagulant applications.", "In one embodiment, the first elastomer coating includes dispersed therein the fibers discussed herein.", "In embodiments, the fiber-containing elastomer is the only elastomer (latex) layer applied.", "In embodiments, the elastomer layer is leached, typically in aqueous fluid, prior to heat curing.", "After heat curing, the elastomer surface can be, in embodiments, chlorinated, followed in embodiments by contacting with a neutralization formulation.", "An illustrative manufacturing process is shown in FIG.", "2.In step 202, the fabric is loaded onto a former.", "In step 204, coagulant is applied to the fabric.", "This step, as with all steps marked with an asterisk (*) is optional.", "In step 206, the coagulant is dried.", "In step 208, elastomer is applied to the fabric.", "In step 210, excess elastomer is allowed to drip off.", "In step 212, the elastomer is air dried.", "In a further option, the former is re-oriented so that the article with its coating primarily faces up.", "Step 214 indicates that steps 204 to 212 or 208 to 212 can be repeated once or more.", "In step 216, texture is applied to the elastomer surface.", "In step 218, the article is leached or rinsed.", "In step 220, the article is cured, typically with heat, to crosslink the elastomer.", "In embodiments, such as those using a substantially polyamide cut-resistant fabric, the mineral fibers used in the invention have a L/D ratio of between about 8 (8:1) and about 27 (27:1).", "In embodiments, the mineral fibers used in the invention have a L/D ratio of between about 9 and about 21.In embodiments, the mineral fibers used in the invention have a L/D ratio of between about 8 or 9 and about 16.The L/D ratio is taken based on the mass weighted average value for length, L, and on the mass weighted average value for diameter, D. (Applicant understands that Lapinus Fibres (Netherlands) measures L as the mass weighted average.", "If that understanding is incorrect, then L is as measured by Lapinus Fibres for fibers of the type described herein.)", "In embodiments, the diameter D for the fibers (mass weighted ay.)", "is from about 5 to about 23 micron, or from about 5 to about 12 or 15 micron.", "In embodiments, the length, L, for the fibers (mass weighted ay.)", "is from about 100 to about 210 micron (100×10−6 m to 210×10−6 m), or from about 100 to about 170 micron.", "In embodiments, the mineral fibers used in the invention have a hardness of about 4 Mohs or higher.", "In embodiments, the mineral fibers have a hardness of about 5 Mohs or higher, or about 6 Mohs.", "The fibers can be, for example, uniformly distributed in the polymer layer.", "In embodiments, the fiber content in the elastomer suspension (prior to coagulation and curing) is about 4% to about 18% w/w, such as about 8 to about 16%, or about 8.5% to about 15.5%, or about 10% to about 14%.", "In embodiments, the fiber content in the elastomer suspension (prior to coagulation and curing) is about 4% to about 10% w/w, such as about 5 to about 7%.", "In embodiments, the fiber content in the elastomer suspension (prior to coagulation and curing) is about 7% to about 13% w/w, such as about 8 to about 12%.", "Illustrative fibers include, from Lapinus Fibres (Netherlands), Rockbrake RB215 (L=150, D=9, L/D=17), Rockforce MS603 (L=125, D=9, L/D=14), and Coatforce CF10 (L=125, D=7, L/D=18), and from NYCO Minerals NYAD MG (L=207, D=23, L/D=9).", "In embodiments, the thickness of the polymer coating with mineral fiber is from about 0.07 to about 0.15 mm, or from about 0.5 mm to about 1.4 mm, such as about 0.7 mm to about 1.1 mm.", "The layer thickness can be measured by microscopic examination of a representative cross-section.", "The inner surface of the elastomer layer can be expected to include a number of penetrations into the fabric.", "These penetrations can be ignored, with the thickness being an average of a representative number of locations away from such penetrations.", "In embodiments, the thickness of the fabric is from about 0.7 to about 4 mm, or about 0.91 to about 1.05 mm.", "The elastomeric layers may be natural rubber latex (including Guayule latex), synthetic rubber latex, or the like, and combinations thereof.", "The synthetic rubber latex may be selected, for example, from the group comprised of polychloroprene, acrylonitrile butadiene copolymer (NBR or “nitrile”) (such as carboxylated acrylonitrile butadiene copolymer), polyisoprene, polyurethane, styrene-butadiene, butyl, and combinations thereof.", "Other polymer coating techniques, such as water or solvent-based resin coatings can be used.", "For example, a polyurethane (such as one having hydrophilic groups) can be applied as a suspension in N-methyl pyrrolidone (NMP), dimethylacetamide (DMAC), or dimethyl sulfoxide (DMSO), with the addition of fiber.", "In embodiments, the elastomeric layer with dispersed mineral fiber is about 5% or more polyurethane and about 60% or more nitrile (wt).", "The article of the invention has a cut-resistance, measured with a cutting implement addressed to the polymer with dispersed mineral fiber coated side of the article, with the measurement pursuant to International ISO 13997:1999.In embodiments, the cut-resistance is 2.1600 grams or higher.", "In embodiments, the article has a cut-resistance of 4 or higher.", "An embodiment with a particularly high cut-resistance of say 9.1600 grams (20 mm) can be directly measured by the standard of International ISO 13997:1999, by adjusting loads as needed and retesting to collect five data points in the 5 to 20 mm cut-through length range.", "This value was compared with a control reference, without mineral fibers.", "In embodiments, the cut-resistance of this sample was 300 grams (20 mm).", "Furthermore, the distance until cut can be normalized to a load of 1000 grams, by fitting the appropriate normalization function to the results at various higher loads, the embodiment with cut-resistance of 9.1600 grams by ISO 13997:1999 is expected to have a cut-resistance of about 191.09 mm (1000 grams).", "Articles according to the invention can include glove, clothing for endeavors with a high risk of cutting (such as motorcycle riding), jackets, sweaters, pants, gators, chaps, wrist covers, forearm covers, arm covers, facemasks, balaclavas, and the like.", "It will be recognized that in some embodiments selected high risk surfaces on the article will be coated with the polymer with dispersed mineral fiber.", "All ranges recited herein include ranges therebetween, and can be inclusive or exclusive of the endpoints.", "Optional included ranges are from integer values therebetween (or inclusive of one original endpoint), at the order of magnitude recited or the next smaller order of magnitude.", "For example, if the lower range value is 0.2, optional included endpoints can be 0.3, 0.4, .", ".", ".", "1.1, 1.2, and the like, as well as 1, 2, 3 and the like; if the higher range is 8, optional included endpoints can be 7, 6, and the like, as well as 7.9, 7.8, and the like.", "One-sided boundaries, such as 3 or more, similarly include consistent boundaries (or ranges) starting at integer values at the recited order of magnitude or one lower.", "For example, 3 or more includes 4 or more, or 3.1 or more.", "In embodiments, the article has one or more features indicative of layer of polymer being applied by a process wherein coagulant is applied to the cut-resistant synthetic fabric to coagulate a coagulation-sensitive dispersion of polymer to form the layer of polymer.", "Such an indicator can include for example the presence of a detectable coagulating salt used for coagulation in an amount greater than would be expected but for the recited coagulation method.", "Such an indicator can include for example the lack of “break-through” in an amount that would be expected given the fabric (e.g., material, weave density, or the like) in the absence of applying coagulant to the fabric (which tends to create dams at the fabric interstices, limiting break-through).", "Break-through is where polymer is formed on the interior of a fabric liner.", "Specific embodiments according to the methods of the present invention will now be described in the following examples.", "The examples are illustrative only, and are not intended to limit the remainder of the disclosure in any way.", "EXAMPLE 1 Gloves made with 85% polyamide yarn were coated with a blend of polyurethane/nitrile formulation, by dipping the glove into a coagulant.", "The coagulant is dried and the glove was then dipped into the elastomer formulation.", "The gloves were vulcanized for around 40 minutes, and 120° C. These gloves were used as control reference (0% fibers).", "The same process was studied for formulations containing different percentages of mineral fibers (as showed in FIG.", "3).", "The results are shown in FIG.", "3, in which 12% and 18% Rockforce MS603 achieved a Level 4 cut-resistance (according with ISO 13997:1999), with the 18% sample measured at 9.15.7 N (or 1600 grams/20 mm).", "18% CoatForce—CF10 also achieved a Level 4 cut-resistance (14.4 N according with ISO 13997:1999).", "In FIG.", "3, the cut-resistances achieved with Rockforce MS603 are shown with filed diamonds (♦); and those achieved with CoatForce CF10 are shown with filled squares (▪).", "A cut level ≥4 is indicated in the Figure by a horizontal line.", "EXAMPLE 2 Gloves made with cotton (cut and sewn) were coated with a blend of polyurethane/nitrile formulation, by dipping the glove into a coagulant.", "The coagulant is dried and the glove was then dipped into the elastomer formulation.", "The gloves were vulcanized for around 40 minutes, and 120° C. These gloves were used as control reference (0% fibers).", "The same process was studied for formulations containing different percentages of mineral fibers (as showed in FIG.", "4A).", "The results are shown in FIG.", "4A, in which 6% Rockforce MS603 achieved a Level 3 cut-resistance (according with EN388).", "By ANSI/ISEA, and 6% achieved Level 3 cut-resistance (<1000 grams) (FIG.", "4B.)", "The invention can be further described with reference to the following numbered embodiments: Embodiment 1 A cut-resistant article comprising: a fabric; and adherent to the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 16, wherein the article has a cut resistance by ISO 13997:1999 (or EN388)(ANSI/ISEA) of 2 or higher, or 3 or higher, or 4 or higher, or 5 or higher.", "Embodiment 2 The cut-resistant article of embodiment 1, wherein the particles have average D mass weighted from about 5 to about 23 micron, or another average D recited herein with respect to any embodiment.", "Embodiment 3 The cut-resistant article of one of embodiments 1 or 2, wherein the particles have average L mass weighted from about 100 to about 210 micron, or another average L recited herein with respect to any embodiment.", "Embodiment 4 The cut-resistant article of one of embodiments 1-3, wherein the particles have hardness of about 5 Mohs or higher, or another hardness recited herein with respect to any embodiment.", "Embodiment 5 The cut-resistant article of one of embodiments 1-4, wherein the fabric is a cut-resistant synthetic fabric.", "Embodiment 6 A cut-resistant article comprising: a cut-resistant synthetic fabric that is a 70% or more polyamide; and adherent to the fabric a layer of polymer comprising about 5% or more polyurethane and about 60% or more nitrile in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27, wherein the article has a cut resistance by ISO 13997:1999 (or EN388)(ANSI/ISEA) of 2 or higher, or 3 or higher, or 4 or higher, and wherein the polymer is adhered to the fabric by coagulation-mediated dip coating onto the fabric, and subsequent curing.", "Embodiment 7 The cut-resistant article of embodiment 6, wherein the particles have average D mass weighted from about 5 to about 23 micron, or another average D recited herein with respect to any embodiment.", "Embodiment 8 The cut-resistant article of one of embodiments 6 or 7, wherein the particles have average L mass weighted from about 100 to about 210 micron, or another average L recited herein with respect to any embodiment.", "Embodiment 9 The cut-resistant article of one of embodiments 6-8, wherein the particles have hardness of about 5 Mohs or higher, or another hardness recited herein with respect to any embodiment.", "Embodiment 10 A method of forming a cut-resistant article comprising: applying a coagulant to a fabric; coagulating on the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27; curing the coagulated polymer; and obtaining the article, which has a cut resistance by ISO 13997:1999 (or EN388)(ANSI/ISEA) of 2 or higher, or 3 or higher, or 4 or higher.", "Embodiment 11 The method of embodiment 10, wherein the particles have average D mass weighted from about 5 to about 23 micron, or another average D recited herein with respect to any embodiment.", "Embodiment 12 The method of one of embodiments 10 or 11, wherein the particles have average L mass weighted from about 100 to about 210 micron, or another average L recited herein with respect to any embodiment.", "Embodiment 13 The method of one of embodiments 10-12, wherein the particles have hardness of about 5 Mohs or higher, or another hardness recited herein with respect to any embodiment.", "Embodiment 14 The method of one of embodiments 10-13, wherein the fabric is a cut-resistant synthetic fabric.", "Embodiment 15 A cut-resistant article comprising: a fabric; and adherent to the fabric a layer of polymer in which is dispersed mineral fibers of hardness about 4 Mohs or higher and having L/D ratio between about 8 and about 27, wherein the article has a cut resistance by ISO 13997:1999 (or EN388)(ANSI/ISEA) of 2 or higher, or 3 or higher, or 4 or higher, or 5 or higher, wherein the article has one or more features indicative of layer of polymer being applied by a process wherein coagulant is applied to the cut-resistant synthetic fabric to coagulate a coagulation-sensitive dispersion of polymer to form the layer of polymer.", "Embodiment 16 The cut-resistant article of embodiment 15, wherein the particles have average D mass weighted from about 5 to about 23 micron, or another average D recited herein with respect to any embodiment.", "Embodiment 17 The cut-resistant article of one of embodiments 15 or 16, wherein the particles have average L mass weighted from about 100 to about 210 micron, or another average L recited herein with respect to any embodiment.", "Embodiment 18 The cut-resistant article of one of embodiments 15-17, wherein the particles have hardness of about 5 Mohs or higher, or another hardness recited herein with respect to any embodiment.", "Embodiment 19 The method of one of embodiments 15-18, wherein the fabric is a cut-resistant synthetic fabric.", "This invention described herein is of a breach or contamination indicating elastomeric article and methods of forming the same.", "Although some embodiments have been discussed above, other implementations and applications are also within the scope of the following claims.", "Although the invention herein has been described with reference to particular embodiments, it is to be understood that these embodiments are merely illustrative of the principles and applications of the present invention.", "It is therefore to be understood that numerous modifications may be made to the illustrative embodiments and that other arrangements may be devised without departing from the spirit and scope of the present invention as defined by the following claims.", "Publications and references, including but not limited to patents and patent applications, cited in this specification are herein incorporated by reference in their entirety in the entire portion cited as if each individual publication or reference were specifically and individually indicated to be incorporated by reference herein as being fully set forth.", "Any patent application to which this application claims priority is also incorporated by reference herein in the manner described above for publications and references." ] ]
Patent_15874206
[ [ "III-V FIN Generation By Lateral Growth On Silicon Sidewall", "A method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate; causing a nucleation of a III-V material in a sidewall of the structure defined by the silicon material; adjusting a growth condition to facilitate a first growth rate of the III-V material in directions along a surface of the sidewall and a second growth rate of the III-V material in a direction laterally from the surface of the sidewall, wherein the second growth rate is less than the first growth rate; and processing the silicon material and the III-V material to form a fin." ], [ "1.A method, comprising: providing a structure defined by a silicon material on a buried oxide layer of a substrate, the structure having at least one sidewall perpendicular to a surface of the buried oxide layer and a top surface parallel to the surface of the buried-oxide layer; disposing a discontinuous oxide mask on the at least one sidewall of the structure to define at least one seed area at at least one discontinuity in the oxide mask; causing a nucleation of a III-V material in the at least one seed area; adjusting a growth condition to facilitate a first growth rate of the III-V material along the sidewall and a second growth rate of the III-V material lateral to the sidewall, wherein the second growth rate is less than the first growth rate; processing the silicon material and the III-V material to form a fin; and disposing a gate over the formed fin.", "2.The method of claim 1, wherein providing a structure defined by a silicon material on a buried oxide layer of a substrate comprises forming a mandrel by a facet-selective wet etch of the silicon material.", "3.The method of claim 2, further comprising forming the buried oxide layer by ion implantation.", "4.The method of claim 1, wherein causing a nucleation of a III-V material in the at least one seed area comprises depositing the III-V material on the seed area at a preselected temperature and pressure to initiate growth of III-V material.", "5.The method of claim 1, further comprising forming a source region and a drain region in the buried oxide layer proximate opposing ends of the gate.", "6.The method of claim 5, wherein forming a source region and a drain region in the buried oxide layer comprises forming n+ source and drain regions via epitaxially grown n+ III-V material and/or by ion implantation into the III-V material.", "7.The method of claim 1, wherein processing the silicon material and the III-V material to form a fin comprises disposing a field oxide layer over the silicon material and the III-V material and planarizing the field oxide layer and the III-V material down to a stop layer of a silicon nitride on the top surface of the sidewall of the structure.", "8.The method of claim 7, further comprising using a wet-etch technique to remove the field oxide layer.", "9.The method of claim 1, further comprising removing the structure defined by the silicon material after disposing the gate over the formed fin.", "10.The method of claim 9, wherein removing the structure defined by the silicon material comprises etching the structure.", "11.The method of claim 10, wherein etching the structure comprises using a selective wet-etch technique.", "12.The method of claim 11, wherein the wet-etch technique comprises using one or more of TMAH, KOH, and ammonium hydroxide.", "13.The method of claim 10, wherein etching the structure comprises using a selective dry-etch technique.", "14.The method of claim 13, wherein the dry-etch technique comprises using XeF2.15.The method of claim 1, wherein the silicon material is either a (110) silicon material or a (112) silicon material.", "16.The method of claim 1, wherein the III-V material comprises a material selected from the group consisting of gallium arsenide (GaAs), aluminum arsenide (AlAs), indium gallium arsenide (InGaAs), indium phosphide (InP), gallium phosphide (GaP), gallium nitride (GaN), gallium arsenide phosphide (GaAsP), gallium indium arsenide antimony phosphide (GaInAsSbP), aluminum gallium arsenide (AlGaAs), aluminum gallium indium arsenide (AlGaInAs), indium arsenide (InAs), indium gallium phosphide (InGaP), indium arsenide antimony phosphide (InAsSbP), indium gallium aluminum phosphide (InGaAlP), and combinations of the foregoing." ], [ "<SOH> BACKGROUND <EOH>The exemplary embodiments of this invention relate generally to semiconductor devices and techniques for the fabrication thereof and, more specifically, to the fabrication of fin-type transistor devices having channels of III-V materials.", "Semiconductors and integrated circuit chips have become widely used in many products due to their decreasing cost and size.", "In the microelectronics industry there is a continued desire to reduce the size of structural features and microelectronic devices in order to provide a greater amount of circuitry on a given chip.", "Doing so generally allows for increased performance (more processing per clock cycle and less heat generated) at lower power levels and lower cost.", "However, the present technology is at or approaching atomic level scaling of certain micro-devices.", "One type of microelectronic device that is continually being reduced in size is a field effect transistor (FET), which is generally defined by a source, a gate, and a drain.", "The action of the FET depends on the flow of majority carriers along a channel that runs past the gate and between the source and drain.", "Current through the channel between the source and drain may be controlled by a transverse electric field under the gate.", "The size of a FET can be reduced by forming the channel in the shape of a fin.", "A FET employing such a channel structure may be referred to as a finFET.", "The fin-shaped channels (or “fins”) may be fabricated of, for example, germanium or III-V materials.", "Such fins may be fabricated on silicon substrates.", "The fabrication of defect-free III-V fins on a silicon substrate, however, may be difficult.", "Current III-V heterogeneous epitaxy techniques (such as aspect ratio trapping and graded buffer growth) and other deposition techniques generally utilize relatively thick buffers of III-V materials (e.g., more than several hundreds of nanometers) and tend to result in the fabricated fins having large numbers of defects." ], [ "<SOH> BRIEF SUMMARY <EOH>In one exemplary aspect, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate; causing a nucleation of a III-V material in a sidewall of the structure defined by the silicon material; adjusting a growth condition to facilitate a first growth rate of the III-V material in directions along a surface of the sidewall and a second growth rate of the III-V material in a direction laterally from the surface of the sidewall, wherein the second growth rate is less than the first growth rate; and processing the silicon material and the III-V material to form a fin.", "In another exemplary aspect, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate, the structure having at least one sidewall perpendicular to a surface of the buried oxide layer and a top surface parallel to the surface of the buried oxide layer; disposing a discontinuous oxide mask on the at least one sidewall of the structure to define at least one seed area at at least one discontinuity in the oxide mask; causing a nucleation of a III-V material in the at least one seed area; adjusting a growth condition to facilitate a first growth rate of the III-V material along the sidewall and a second growth rate of the III-V material lateral to the sidewall, wherein the second growth rate is less than the first growth rate; processing the silicon material and the III-V material to form a fin; and disposing a gate over the formed fin.", "In another exemplary aspect, a method comprises forming a mandrel on a buried oxide layer on a silicon substrate, the forming of the mandrel being by a facet-selective wet etch of a ( 110 ) silicon material, the mandrel having at least one sidewall perpendicular to a surface of the buried oxide layer, the sidewall having a top surface extending in a < 110 > direction orthogonal to the surface of the buried oxide layer and a side surface extending in a < 111 > direction parallel to a surface of the buried oxide layer; disposing an oxide mask on the at least one sidewall of the mandrel in the < 111 > direction to define at least one seed area; causing a growth of a III-V material on the at least one sidewall of the mandrel from the at least one seed area in the < 110 > and < 112 > directions and in the < 111 > direction; adjusting a growth condition to facilitate a faster growth rate of the III-V material in the < 110 > and < 112 > directions and a slower growth rate in the < 111 > direction; processing the ( 110 ) silicon material and the III-V material to form a fin; and disposing a gate stack over the formed fin." ], [ "CROSS REFERENCE TO RELATED APPLICATION This patent application is a divisional application of copending U.S. patent application Ser.", "No.", "14/876,986, filed on Oct. 7, 2015, the disclosure of which is incorporated by reference herein in its entirety.", "BACKGROUND The exemplary embodiments of this invention relate generally to semiconductor devices and techniques for the fabrication thereof and, more specifically, to the fabrication of fin-type transistor devices having channels of III-V materials.", "Semiconductors and integrated circuit chips have become widely used in many products due to their decreasing cost and size.", "In the microelectronics industry there is a continued desire to reduce the size of structural features and microelectronic devices in order to provide a greater amount of circuitry on a given chip.", "Doing so generally allows for increased performance (more processing per clock cycle and less heat generated) at lower power levels and lower cost.", "However, the present technology is at or approaching atomic level scaling of certain micro-devices.", "One type of microelectronic device that is continually being reduced in size is a field effect transistor (FET), which is generally defined by a source, a gate, and a drain.", "The action of the FET depends on the flow of majority carriers along a channel that runs past the gate and between the source and drain.", "Current through the channel between the source and drain may be controlled by a transverse electric field under the gate.", "The size of a FET can be reduced by forming the channel in the shape of a fin.", "A FET employing such a channel structure may be referred to as a finFET.", "The fin-shaped channels (or “fins”) may be fabricated of, for example, germanium or III-V materials.", "Such fins may be fabricated on silicon substrates.", "The fabrication of defect-free III-V fins on a silicon substrate, however, may be difficult.", "Current III-V heterogeneous epitaxy techniques (such as aspect ratio trapping and graded buffer growth) and other deposition techniques generally utilize relatively thick buffers of III-V materials (e.g., more than several hundreds of nanometers) and tend to result in the fabricated fins having large numbers of defects.", "BRIEF SUMMARY In one exemplary aspect, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate; causing a nucleation of a III-V material in a sidewall of the structure defined by the silicon material; adjusting a growth condition to facilitate a first growth rate of the III-V material in directions along a surface of the sidewall and a second growth rate of the III-V material in a direction laterally from the surface of the sidewall, wherein the second growth rate is less than the first growth rate; and processing the silicon material and the III-V material to form a fin.", "In another exemplary aspect, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate, the structure having at least one sidewall perpendicular to a surface of the buried oxide layer and a top surface parallel to the surface of the buried oxide layer; disposing a discontinuous oxide mask on the at least one sidewall of the structure to define at least one seed area at at least one discontinuity in the oxide mask; causing a nucleation of a III-V material in the at least one seed area; adjusting a growth condition to facilitate a first growth rate of the III-V material along the sidewall and a second growth rate of the III-V material lateral to the sidewall, wherein the second growth rate is less than the first growth rate; processing the silicon material and the III-V material to form a fin; and disposing a gate over the formed fin.", "In another exemplary aspect, a method comprises forming a mandrel on a buried oxide layer on a silicon substrate, the forming of the mandrel being by a facet-selective wet etch of a (110) silicon material, the mandrel having at least one sidewall perpendicular to a surface of the buried oxide layer, the sidewall having a top surface extending in a <110> direction orthogonal to the surface of the buried oxide layer and a side surface extending in a <111> direction parallel to a surface of the buried oxide layer; disposing an oxide mask on the at least one sidewall of the mandrel in the <111> direction to define at least one seed area; causing a growth of a III-V material on the at least one sidewall of the mandrel from the at least one seed area in the <110> and <112> directions and in the <111> direction; adjusting a growth condition to facilitate a faster growth rate of the III-V material in the <110> and <112> directions and a slower growth rate in the <111> direction; processing the (110) silicon material and the III-V material to form a fin; and disposing a gate stack over the formed fin.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS The foregoing and other aspects of exemplary embodiments are made more evident in the following Detailed Description, when read in conjunction with the attached Drawing Figures, wherein: FIG.", "1 is a perspective schematic representation of a portion of a silicon mandrel on which fins may be grown; FIG.", "2 is a perspective schematic representation of the silicon mandrel of FIG.", "1 disposed on a handle wafer comprising an insulating base substrate and an overlying buried oxide layer; FIG.", "3 is a top view of the schematic representation of FIG.", "2; FIGS.", "4 and 5 are perspective schematic representations of another exemplary embodiment of a silicon mandrel disposed on a handle substrate; FIGS.", "6-9 are perspective schematic representations of other exemplary embodiments of a silicon mandrel disposed on a handle substrate; FIG.", "10 is perspective schematic representation of the silicon mandrel of FIG.", "2 having fins laterally grown on opposing sidewalls; FIG.", "11 is a top view of the schematic representation of FIG.", "10; FIG.", "12 is a perspective schematic representation of the mandrel and fins of FIG.", "10 covered by a field oxide layer; FIG.", "13 is a perspective schematic representation of the mandrel, fins, and field oxide layer of FIG.", "12 polished down to an upper surface of a stop layer on the mandrel; FIG.", "14 is a perspective schematic representation of a mandrel/fin arrangement having gate stacks disposed thereon; FIG.", "15 is a top view of the schematic representation of FIG.", "14; FIG.", "16 is a perspective schematic representation of the mandrel/fin arrangement and gate stacks of FIG.", "14 having source/drain regions disposed thereon; FIG.", "17 is a top view of the schematic representation of FIG.", "16; FIG.", "18 is a perspective schematic representation of an exemplary embodiment of fins and gate stacks without a mandrel; FIG.", "19 is a top view of the schematic representation of FIG.", "18; FIG.", "20 is a top view of the schematic representation of FIG.", "18 having source/drain regions disposed on the fins; FIG.", "21 is a block diagram of various electronic devices and apparatuses that may be suitable for use in forming the structures described herein; and FIG.", "22 is a logic flow diagram that illustrates the operation of an exemplary method, and a result of execution of computer program instructions embodied on a computer readable memory, in accordance with an exemplary embodiment of the manufacture of structures described herein.", "DETAILED DESCRIPTION The word “exemplary” is used herein to mean “serving as an example, instance, or illustration.” Any embodiment described herein as “exemplary” is not necessarily to be construed as preferred or advantageous over other embodiments.", "All of the embodiments described in this Detailed Description are exemplary embodiments provided to enable persons skilled in the art to make or use the invention and not to limit the scope of the invention which is defined by the claims.", "As used herein, the term “III-V” refers to inorganic crystalline compound semiconductors having at least one Group III element and at least one Group V element.", "Exemplary III-V materials for use in the structures and methods described herein include, but are not limited to, gallium arsenide (GaAs), aluminum arsenide (AlAs), gallium phosphide (GaP), gallium nitride (GaN), gallium arsenide phosphide (GaAsP), gallium indium arsenide antimony phosphide (GaInAsSbP), aluminum gallium arsenide (AlGaAs), aluminum gallium indium arsenide (AlGaInAs), indium arsenide (InAs), indium gallium phosphide (InGaP), indium gallium arsenide (InGaAs), indium arsenide antimony phosphide (InAsSbP), indium gallium aluminum phosphide (InGaAlP), and combinations of the foregoing.", "As shown in FIG.", "1, one exemplary embodiment of a structure for use in fabricating a finFET or a fin-type transistor device having active areas (such as channels) formed by III-V material(s) is designated generally by the reference number 100.The structure comprises a mandrel and is hereinafter referred to as “mandrel 100.” The mandrel 100 can comprise silicon or other insulative material.", "In some embodiments illustrated herein, the mandrel 100 is a silicon substrate of silicon-on-insulator (SOI) material or bulk material having a (110) crystal configuration.", "Because of the (110) configuration of the silicon forming the mandrel 100, the silicon of the mandrel 100 would have a top surface 105 having crystal orientations of {110} and sidewalls 110 having crystal orientations of {111}.", "Referring to FIGS.", "2-22, exemplary embodiments of methods of fabricating a finFET or a fin-type device having one or more fins using the mandrel and comprising a III-V material are shown.", "As shown in FIGS.", "2 and 3, the mandrel 100 may be disposed on a handle wafer 115 comprising an insulating silicon base substrate 120 having an overlying buried oxide (BOX) layer 125, with the mandrel 100 being disposed directly on the BOX layer 125.The mandrel 100 may comprise the silicon having the (110) configuration with a silicon etch mask/chemical mechanical polish (CMP) stop layer 130 (hereinafter “stop layer 130”) disposed on the top surface 105 (in the <110> direction) and one or more sidewall oxide masks 135 (or a discontinuous sidewall oxide mask 135) disposed on portions of the opposing sidewalls in the <111> directions.", "The stop layer 130 can comprise a silicon nitride (SiNx) such as, for example, SiN, Si3N4, or the like, or SiO2, or Al2O3.The sidewall oxide masks 135 can comprise any suitable oxide such as, for example, SiO2, as well as other materials such as silicon nitrides, and are deposited on the sidewall by any suitable deposition technique or by thermal oxidation.", "The mandrel 100 may be formed by facet-selective wet etch on a (110) crystalline configuration of the SOI material or the bulk material such that the opposing sidewalls of the mandrel 100 are <111> faceted sidewalls that are perpendicular to an upper surface 140 of the BOX layer 125.The BOX layer 125 may be formed by implantation of oxide ions.", "A seed area 145 is defined on each sidewall of the mandrel 100 by a gap, break, or discontinuity between sidewall oxide masks 135.If only one sidewall oxide mask 135 is employed, the seed area 145 may be defined by an opening in the sidewall oxide mask 135 or a through hole extending through the material of the sidewall oxide mask 135 down to the sidewall of the mandrel 100.The seed area 145 allows for the generation of nucleations in the III-V material forming the fin in a controlled manner (and without a buffer region between the III-V material and the material of the mandrel 100).", "In another exemplary embodiment, as shown in FIGS.", "4 and 5, a (112) oriented silicon surface wafer can be used to form the <111> direction sidewall.", "As shown in FIG.", "4, the insulating silicon base substrate 120 having the BOX layer 125 may be provided with an overlying layer of (112) silicon 127 on the BOX layer 125 to form the mandrel 100 of (112) silicon.", "The stop layer 130 may be disposed on the overlying layer of (112) silicon 127.The stop layer 130 can comprise a silicon nitride (SiNx) such as, for example, SiN, Si3N4, or the like, or SiO2, or Al2O3.The overlying layer of (112) silicon 127 may be patterned and masked.", "As shown in FIG.", "5, mandrels 100 that are parallel to the <112> direction may be formed by a dry-etch technique (e.g., XeF2) or an anisotropic wet-etching of the silicon using tetramethylammonium hydroxide (TMAH) or potassium hydroxide (KOH).", "In such an embodiment, the silicon mandrel 100 is formed with a vertical sidewall that is normal to the <111> direction and that has an atomically flat surface due to the nature of facet-selective etching.", "Another exemplary embodiment is shown in FIGS.", "6-9.As shown in FIG.", "6, the mandrel 100 may be formed using (110) or (112) silicon directly on the silicon base substrate 120 using any suitable anisotropic wet-etch technique (e.g., using TMAH or KOH).", "As shown in FIG.", "7, SiO2 is deposited around the mandrel 100 to form a bottom oxide layer 131a and over the mandrel 100 and the bottom oxide layer 131a to form a top oxide layer 131b.", "As shown in FIG.", "8, the top oxide layer 131b is planarized down to the stop layer 130 and the bottom oxide layer 131a.", "As shown in FIG.", "9, the bottom oxide layer 131a below the stop layer 130 is etched to expose the sidewalls of the mandrel 100.Sidewall oxide masks 135 may be disposed on the sidewalls to form the seed areas 145.Referring now to FIGS.", "10 and 11, the III-V material is laterally grown from the seed areas 145 on the sides of the mandrel 100 to form the active areas.", "Although the III-V material may be grown from any of the seed areas 145 described above, FIGS.", "10 and 11 are depicted to show lateral growth from the seed areas 145 of the mandrel 100 and handle wafer 115 of FIG.", "2.Since only a small portion of the silicon of the sidewall of the mandrel 100 is exposed to the III-V material in the seed area 145, growth of the III-V material can be from a single nucleus of III-V material deposited on the (110) configuration of the SOI material or the bulk material at a preselected temperature and pressure to initiate the growth, thereby allowing for high quality growth to be achieved due to the substantial absence of defects that can be generated when two growth fronts merge.", "Conditions (e.g., temperature, pressure, and the like) are selected and adjusted such that a growth rate of the III-V material in the <110> direction is faster than a growth rate in the <111> direction, which results in a structure on each side of the mandrel 100 to define fins 150, such fins 150 having a height h (FIG.", "10) that is substantially greater than a thickness t (FIG.", "11).", "As shown in FIG.", "12, upon growth of the fins 150, a field oxide layer 155 (or equivalent material for CMP) can be disposed on the BOX layer 125 and over the fins 150 and mandrels 100.The field oxide layer 155 can comprise any suitable oxide material (e.g., silicon dioxide, spin-on-glass, or any dielectric material that can be selectively polished to the dielectric on the mandrels 100) for passivating and protecting the surfaces of the BOX layer 125, the fins 150, and the mandrels 100.As shown in FIG.", "13, a CMP process can be carried out on the field oxide layer 155 to planarize the field oxide and the fins 150 down to the surface of the stop layer 130 on the mandrel 100.As shown in FIGS.", "14 and 15, the portions of the field oxide layer 155 disposed on the BOX layer 125 and below the stop layer 130 (and not removed by the CMP process) can be removed by a wet-etch technique such as acid wash with hydrofluoric acid (HF).", "Also, portions of the sidewall oxide mask 135 may be also removed.", "After removal of the field oxide layer 155, one or more gate stacks 160 are formed over the fins 150 and the mandrel 100.In embodiments in which the gate stack 160 is formed as a replacement metal gate (RMG), a dummy gate structure is formed from hardmask material and sacrificial gate material, the dummy gate structure being used as a placeholder which is subsequently removed (e.g., by reactive ion etching) and replaced with a metal gate structure (e.g., using any suitable metal deposition process).", "In embodiments in which the gate stack 160 is formed for gate-first flow, both metal gate material and polysilicon gate material may be deposited, and the polysilicon gate material and portions of the metal gate material are subtractively etched.", "In either embodiment of formation of the gate stack 160, the gate stack 160 is aligned with the laterally grown III-V material of the fins 150.The gate stack 160 may be deposited over the III-V material defining the fins 150 on the sides of the mandrel 100 as well as over the top surface of the planarized stop layer 130 such that the gate stack 160 is defined by lower gate portions 162 extending from the sides of the fins 150 as well as an upper gate portion 164 extending from upper surfaces of the lower gate portions 162 and across the III-V material and the stop layer 130 on the mandrel 100.As shown in FIGS.", "16 and 17, n+ source and drain regions 170 may be formed on the sides of the III-V material of the fins 150.The source and drain regions 170 may be formed via epitaxially grown n-type doped III-V material or doping from ion implantation into the III-V material.", "As can be seen in FIG.", "17, the III-V material may be continuous in the <112> direction along the sides of the mandrel 100, whereas the source and drain regions 170 may be discontinuous in the <112> directions along the sides of the III-V material of the fins 150 and separated by the lower gate portions 162.As shown in FIGS.", "18 and 19, in another exemplary embodiment, the mandrel 100 can be removed prior to the formation of the gate stack 160 over the fins 150.In such an embodiment, the mandrel 100 may be removed by subjecting the mandrel 100 to an anisotropic selective wet-etch technique (e.g., TMAH, KOH, ammonium hydroxide (NH4OH), or the like) or a dry-etch technique (e.g., XeF2 or the like).", "Upon removal of the mandrel 100, the gate stack 160 is formed laterally over and between the parallel fins 150 previously formed on each opposing side of the mandrel 100.In this embodiment, lower gate portions 162 are not only formed to extend outward from the fins 150, but also between the fins 150.Also, the upper gate portion 164 may be comprised of two portions.", "As shown in FIG.", "20, n+ source and drain regions 170 may be formed on both sides of the III-V material of the fins 150.The source and drain regions 170 may be formed via an epitaxy process or by ion implantation.", "As can be seen in FIG.", "20, the III-V material may be continuous in the <112> direction under the upper gate portions 164, whereas the source and drain regions 170 may be discontinuous in the <112> directions along the sides of the III-V material of the fins 150 and separated by the lower gate portions 162.Referring now to FIG.", "21, a simplified block diagram of various electronic devices and apparatuses that are suitable for use in practicing the exemplary embodiments described herein is shown.", "For example, a computer 1510 may be used to control one or more of the processes as described above.", "The computer 1510 includes a controller, such as a computer or a data processor (DP) 1514 and a computer-readable memory medium embodied as a memory (MEM) 1516 that stores a program of computer instructions (PROG) 1518.The PROG 1518 includes program instructions that, when executed by the associated DP 1514, enable the various electronic devices and apparatuses to operate in accordance with exemplary embodiments.", "That is, various exemplary embodiments may be implemented at least in part by computer software executable by the DP 1514 of the computer 1510, or by hardware, or by a combination of software and hardware (and firmware).", "The computer 1510 may also include dedicated processors, for example a processor 1515 that controls the conditions for growth of the III-V material from the seed areas 145.The computer readable MEM 1516 may be of any type suitable to the local technical environment and may be implemented using any suitable data storage technology, such as semiconductor based memory devices, flash memory, magnetic memory devices and systems, optical memory devices and systems, fixed memory, and removable memory.", "The DP 1514 may be of any type suitable to the local technical environment, and may include one or more of general purpose computers, special purpose computers, microprocessors, digital signal processors (DSPs), and processors based on a multicore processor architecture, as non-limiting examples.", "The exemplary embodiments, as discussed herein and as particularly described with respect to exemplary methods, may be implemented in conjunction with a program storage device (e.g., at least one memory) readable by a machine, tangibly embodying a program of instructions (e.g., a program or computer program) executable by the machine for performing operations.", "The operations comprise utilizing the exemplary embodiments of the method.", "Based on the foregoing, it should be apparent that various exemplary embodiments provide methods to generate fins by substantially lateral growth on a silicon sidewall.", "FIG.", "22 is a logic flow diagram that illustrates the operation of one exemplary embodiment of a method 1600 (and a result of an execution of computer program instructions (such as PROG 1518)), in accordance with the exemplary embodiments.", "In accordance with these exemplary embodiments, at block 1610, a mandrel of (110) silicon is disposed on a handle wafer.", "At block 1620, a stop layer of SiNx is disposed on the silicon of the top of the mandrel (in the <110> direction), and an oxide mask is disposed on portions of the sidewalls of the mandrel (in the <111> directions).", "At block 1630, III-V material is grown from portions of the sidewalls not covered by the oxide mask, the grown material forming fins.", "Growth of the fins occurs in both the <110> and <111> directions from nucleation sites.", "At block 1640, the fins and the mandrel are covered with a field oxide layer.", "Processing of the field oxide layer using CMP is carried out at block 1650 to planarize the field oxide layer and the fins down to the stop layer.", "At block 1660, the remaining field oxide layer and portions of the sidewall oxide mask are removed.", "At 1665, a decision is made as to whether the mandrel is desired in the final finFET or fin-type device.", "If the mandrel is not desired, the mandrel is removed at block 1670, and control passes to block 1680 to form a gate stack over the fins.", "If the mandrel is desired at 1665, control passes directly to block 1680.At block 1690, source/drain regions are formed adjacent to the fins.", "The various blocks shown in FIG.", "16 may be viewed as method steps, and/or as operations that result from operation of computer program code, and/or as a plurality of coupled logic circuit elements constructed to carry out the associated function(s).", "In one exemplary embodiment, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate; causing a nucleation of a III-V material in a sidewall of the structure defined by the silicon material; adjusting a growth condition to facilitate a first growth rate of the III-V material in directions along a surface of the sidewall and a second growth rate of the III-V material in a direction laterally from the surface of the sidewall, wherein the second growth rate is less than the first growth rate; and processing the silicon material and the III-V material to form a fin.", "The method may further comprise forming a source region and a drain region on opposing sides of the fin and forming a gate extending across the fin between the source region and the drain region.", "Forming a source region and a drain region may comprise doping using one or more of an epitaxy process and an ion implantation process.", "Processing the silicon material and the III-V material to form a fin may comprise disposing an oxide layer over the structure defined by a silicon material and the buried oxide layer, planarizing the oxide layer and the fin, and removing excess oxide layer using a wet-etch technique (e.g., an acid wash).", "The method may further comprise removing the structure defined by a silicon material.", "The silicon material may be either a (110) silicon material or a (112) silicon material.", "In another exemplary embodiment, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate, the structure having at least one sidewall perpendicular to a surface of the buried oxide layer and a top surface parallel to the surface of the buried oxide layer; disposing a discontinuous oxide mask on the at least one sidewall of the structure to define at least one seed area at at least one discontinuity in the oxide mask; causing a nucleation of a III-V material in the at least one seed area; adjusting a growth condition to facilitate a first growth rate of the III-V material along the sidewall and a second growth rate of the III-V material lateral to the sidewall, wherein the second growth rate is less than the first growth rate; processing the silicon material and the III-V material to form a fin; and disposing a gate over the formed fin.", "Providing a structure defined by a silicon material on a buried oxide layer of a substrate may comprise forming a mandrel by a facet-selective wet etch of the silicon material.", "The method may further comprise forming the buried oxide layer by ion implantation.", "Causing a nucleation of a III-V material in the at least one seed area may comprise depositing the III-V material on the seed area at a preselected temperature and pressure to initiate growth of III-V material.", "The method may further comprise forming a source region and a drain region in the buried oxide layer proximate opposing ends of the gate.", "Forming a source region and a drain region in the buried oxide layer may comprise forming n+ source and drain regions via epitaxially grown n+ III-V material and/or by ion implantation into the III-V material.", "Processing the silicon material and the III-V material to form a fin may comprise disposing a field oxide layer over the silicon material and the III-V material and planarizing the field oxide layer and the III-V material down to a stop layer of a silicon nitride on the top surface of the sidewall of the structure.", "The method may further comprise removing the structure defined by the silicon material after forming the gate over the formed fin.", "The silicon material may be either a (110) silicon material or a (112) silicon material.", "In another exemplary embodiment, a method comprises forming a mandrel on a buried oxide layer on a silicon substrate, the forming of the mandrel being by a facet-selective wet etch of a (110) silicon material, the mandrel having at least one sidewall perpendicular to a surface of the buried oxide layer, the sidewall having a top surface extending in a <110> direction orthogonal to the surface of the buried oxide layer and a side surface extending in a <111> direction parallel to a surface of the buried oxide layer; disposing an oxide mask on the at least one sidewall of the mandrel in the <111> direction to define at least one seed area; causing a growth of a III-V material on the at least one sidewall of the mandrel from the at least one seed area in the <110> and <112> directions and in the <111> direction; adjusting a growth condition to facilitate a faster growth rate of the material in the <110> and <112> directions and a slower growth rate-in the <111> direction; processing the (110) silicon material and the III-V material to form a fin; and disposing a gate stack over the formed fin.", "Causing a growth of a III-V material on the at least one sidewall of the mandrel from the at least one seed area in the <110> direction and in the <111> direction may comprise depositing the III-V material on the at least one seed area at a preselected temperature and pressure.", "After growth of the III-V material on the at least one sidewall of the mandrel, the III-V may be substantially defect-free.", "The method may further comprise removing the mandrel after disposing the gate stack over the formed fin, the removing of the mandrel being by subjecting the mandrel to a selective wet-etch or dry-etch technique.", "The III-V material may comprise a material selected from the group consisting of gallium arsenide (GaAs), aluminum arsenide (AlAs), indium gallium arsenide (InGaAs), indium phosphide (InP), gallium phosphide (GaP), gallium nitride (GaN), gallium arsenide phosphide (GaAsP), gallium indium arsenide antimony phosphide (GaInAsSbP), aluminum gallium arsenide (AlGaAs), aluminum gallium indium arsenide (AlGaInAs), indium arsenide (InAs), indium gallium phosphide (InGaP), indium arsenide antimony phosphide (InAsSbP), indium gallium aluminum phosphide (InGaAlP), and combinations of the foregoing.", "The foregoing description has provided by way of exemplary and non-limiting examples a full and informative description of the best method and apparatus presently contemplated by the inventors for carrying out various exemplary embodiments.", "However, various modifications and adaptations may become apparent to those skilled in the relevant arts in view of the foregoing description, when read in conjunction with the accompanying drawings and the appended claims.", "However, all such and similar modifications will still fall within the scope of the teachings of the exemplary embodiments.", "Furthermore, some of the features of the preferred embodiments could be used to advantage without the corresponding use of other features.", "As such, the foregoing description should be considered as merely illustrative of the principles, and not in limitation thereof." ] ]
Patent_15874208
[ [ "PHOTONICS CHIP", "The present disclosure relates to semiconductor structures and, more particularly, to photonics chips and methods of manufacture.", "A structure includes: a photonics chip having a grated optical coupler; an interposer attached to the photonics chip, the interposer having a grated optical coupler; an optical epoxy material provided between the grated optical coupler of the photonics chip and the grated optical coupler of the interposer; and epoxy underfill material provided at interstitial regions between the photonics chip and the interposer which lie outside of an area of the grated optical couplers of the photonics chip and the interposer." ], [ "1.A structure comprising: a photonics chip having a grated optical coupler; an interposer attached to the photonics chip, the interposer having a grated optical coupler; an optical epoxy material provided between the grated optical coupler of the photonics chip and the grated optical coupler of the interposer; and epoxy underfill material provided at interstitial regions between the photonics chip and the interposer which lie outside of an area of the grated optical couplers of the photonics chip and the interposer.", "2.The structure of claim 1, wherein the optical epoxy material is provided within a cavity formed between the grated optical couplers of the photonics chip and the interposer.", "3.The structure of claim 2, further comprising a barrier material which is structured to form the cavity and to maintain the optical epoxy material within the cavity.", "4.The structure of claim 3, wherein the barrier material is a cured underfill material.", "5.The structure of claim 4, wherein the optical epoxy material is a low viscosity optical epoxy material, compared to the cured underfill material.", "6.The structure of claim 1, wherein the epoxy underfill material is a polymer material with a coefficient of thermal expansion (CTE) that substantially matches the CTE of the photonics chip and the interposer.", "7.The structure of claim 1, wherein the optical epoxy material is localized within an optical transmission region of the grated optical couplers of the photonics chip and the interposer.", "8.The structure of claim 1, wherein the optical epoxy material and the epoxy underfill material are flowable materials.", "9.A structure, comprising: a photonics chip mounted to an interposer with a plurality of solder connections; at least one cavity formed between the photonics chip and the interposer; grated optical couplers provided on opposing sides of the at least one cavity; at least one waveguide structure providing an optical transmission to the grated optical couplers; an optical fiber coupled to the waveguide structure; an optical epoxy material provided within the at least one cavity between the grated optical couplers; and epoxy underfill material provided at interstitial regions between the plurality of solder connections.", "10.The structure of claim 9, wherein the at least one cavity is at least partly surrounded by a barrier material.", "11.The structure of claim 10, wherein the barrier material is a no or low flow underfill material.", "12.The structure of claim 11, wherein the no or low flow underfill material is a polymer material.", "13.The structure of claim 12, wherein the polymer material is a cured material which prevents the optical epoxy material from exiting from the at least one cavity.", "14.The structure of claim 13, wherein the optical epoxy material is a low viscosity optical epoxy material, compared to the cured underfill material.", "15.The structure of claim 9, wherein the optical epoxy material is localized within an optical transmission region of the grated optical couplers of the photonics chip and the interposer.", "16.The structure of claim 9, wherein the optical epoxy material and the epoxy underfill material are flowable materials.", "17.A method comprising: connecting a photonics chip to an interposer with a plurality of solder connections; filling a space between grated optical couples of the photonics chip and the interposer with optical epoxy material; and filling interstitial spaces between the photonics chip and the interposer with underfill material which is different than the optical epoxy material.", "18.The method of claim 17, wherein the optical epoxy is applied in local areas, followed by attaching the photonics chip to the interposer, followed by applying the underfill material using capillary flow underfill processes.", "19.The method of claim 17, wherein the optical epoxy is applied in local areas of optical transmission, followed by applying the underfill material and attaching the photonics chip to the interposer.", "20.The method of claim 17, wherein the photonics chip is attached to the interposer followed by applying the optical epoxy in local areas of optical transmission and the underfill material in the interstitial spaces." ], [ "<SOH> BACKGROUND <EOH>Silicon photonics chips are being developed for high speed interconnects between dies.", "Waveguides can be built on SOI wafers and can be integrated with CMOS devices.", "In these structures, though, a connection must be made between an “off-chip” optical fiber and the waveguide.", "Out-of-plane coupling uses an optical grating to couple light from the fiber to the waveguide, but this limits the optical signal to one wavelength.", "In-plane coupling, on the other hand, allows broadband transmission (e.g., multiple wavelengths) and hence higher bandwidth." ], [ "<SOH> SUMMARY <EOH>In an aspect of the disclosure, a structure comprises: a photonics chip having a grated optical coupler; an interposer attached to the photonics chip, the interposer having a grated optical coupler; an optical epoxy material provided between the grated optical coupler of the photonics chip and the grated optical coupler of the interposer; and epoxy underfill material provided at interstitial regions between the photonics chip and the interposer which lie outside of an area of the grated optical couplers of the photonics chip and the interposer.", "In an aspect of the disclosure, a structure comprises: a photonics chip mounted to an interposer with a plurality of solder connections; at least one cavity formed between the photonics chip and the interposer; grated optical couplers provided on opposing sides of the at least one cavity; at least one waveguide structure providing an optical transmission to the grated optical couplers; an optical fiber coupled to the waveguide structure; an optical epoxy material provided within the at least one cavity between the grated optical couplers; and epoxy underfill material provided at interstitial regions between the plurality of solder connections.", "In an aspect of the disclosure, a method comprises: connecting a photonics chip to an interposer with a plurality of solder connections; filling a space between grated optical couples of the photonics chip and the interposer with optical epoxy material; and filling interstitial spaces between the photonics chip and the interposer with underfill material which is different than the optical epoxy material." ], [ "FIELD OF THE INVENTION The present disclosure relates to semiconductor structures and, more particularly, to photonics chips and methods of manufacture.", "BACKGROUND Silicon photonics chips are being developed for high speed interconnects between dies.", "Waveguides can be built on SOI wafers and can be integrated with CMOS devices.", "In these structures, though, a connection must be made between an “off-chip” optical fiber and the waveguide.", "Out-of-plane coupling uses an optical grating to couple light from the fiber to the waveguide, but this limits the optical signal to one wavelength.", "In-plane coupling, on the other hand, allows broadband transmission (e.g., multiple wavelengths) and hence higher bandwidth.", "SUMMARY In an aspect of the disclosure, a structure comprises: a photonics chip having a grated optical coupler; an interposer attached to the photonics chip, the interposer having a grated optical coupler; an optical epoxy material provided between the grated optical coupler of the photonics chip and the grated optical coupler of the interposer; and epoxy underfill material provided at interstitial regions between the photonics chip and the interposer which lie outside of an area of the grated optical couplers of the photonics chip and the interposer.", "In an aspect of the disclosure, a structure comprises: a photonics chip mounted to an interposer with a plurality of solder connections; at least one cavity formed between the photonics chip and the interposer; grated optical couplers provided on opposing sides of the at least one cavity; at least one waveguide structure providing an optical transmission to the grated optical couplers; an optical fiber coupled to the waveguide structure; an optical epoxy material provided within the at least one cavity between the grated optical couplers; and epoxy underfill material provided at interstitial regions between the plurality of solder connections.", "In an aspect of the disclosure, a method comprises: connecting a photonics chip to an interposer with a plurality of solder connections; filling a space between grated optical couples of the photonics chip and the interposer with optical epoxy material; and filling interstitial spaces between the photonics chip and the interposer with underfill material which is different than the optical epoxy material.", "BRIEF DESCRIPTION OF THE DRAWINGS The present disclosure is described in the detailed description which follows, in reference to the noted plurality of drawings by way of non-limiting examples of exemplary embodiments of the present disclosure.", "FIG.", "1 shows a top view of a photonics chip positioned on an interposer with optical fibers in accordance with aspects of the present disclosure.", "FIG.", "2 shows a top view of a photonics chip positioned on an interposer with optical fibers in accordance with additional aspects of the present disclosure.", "FIG.", "3 shows a cross-sectional view of the photonics chip positioned on an interposer with optical fibers in accordance with aspects of the present disclosure.", "FIG.", "4 shows cross-sectional view of the photonics chip positioned on an interposer with optical fibers in accordance with additional aspects of the present disclosure.", "DETAILED DESCRIPTION The present disclosure relates to semiconductor structures and, more particularly, to photonics chips and methods of manufacture.", "In more specific embodiments, the photonics chips comprise dual underfill material.", "The dual underfill material includes, e.g., an optical epoxy and conventional underfill material.", "In embodiments, the optical epoxy is provided in localized regions of the die and interposer where optical transmission is required, with the conventional underfill material provided in remaining regions (i.e., where optical transmission is not required).", "In more specific embodiments, the optical epoxy is provided at the interface of grated optical couplers of the photonics chip and interposer, whereas, the conventional underfill material is filled in interstitial regions outside of the grated optical couplers, providing mechanical and structural integrity to the joined interposer and die (e.g., photonics chip).", "Advantageously, the optical epoxy provides an improved optical pathway between an optical fiber and the grated optical couplers of the photonics chip.", "The conventional underfill is typically applied between the photonics chip and the interposer to provide mechanical support for solder bump connections.", "Although conventional underfill materials have preferred coefficient of thermal efficient matching with other structures of the photonics chip, they are known to exhibit poor optical qualities.", "That is, conventional underfill materials degrade optical transmission because the index of refraction is not optimized.", "Optical epoxies, on the other hand, provide high optical transmission, but these materials have high coefficient of thermal expansion (CTE), and therefore will result in high stress and possible mechanical failure during assembly.", "Hence, the photonics chip described herein optimizes both optical transmission and low CTE underfill materials to provide an improved photonics chip with high yields.", "The photonics chips of the present disclosure can be manufactured in a number of ways using a number of different tools.", "In general, though, the methodologies and tools are used to form structures with dimensions in the micrometer and nanometer scale.", "The methodologies, i.e., technologies, employed to manufacture the photonics chip of the present disclosure have been adopted from integrated circuit (IC) technology.", "For example, the structures are built on wafers and are realized in films of material patterned by photolithographic processes on the top of a wafer.", "In particular, the fabrication of the photonics chips uses three basic building blocks: (i) deposition of thin films of material on a substrate, (ii) applying a patterned mask on top of the films by photolithographic imaging, and (iii) etching the films selectively to the mask.", "FIG.", "1 shows a top view of a photonics chip positioned on an interposer with optical fibers in accordance with aspects of the present disclosure.", "More specifically, the structure 5 includes a substrate 10 (e.g., photonics chip) mounted on an interposer 15.In embodiments, the photonics chip 10 includes a waveguide structure (see, e.g., FIGS.", "3 and 4) and a plurality of connections 20.In embodiments, the plurality of connections 20 are composed of a ball grid array and, more specifically, a plurality of solder balls.", "In embodiments, the solder balls can be, e.g., controlled collapse chip connections (C4 connections).", "As one of skill in the art would understand, C4 connections is a process for interconnecting semiconductor devices, such as integrated circuit chips to external circuitry with solder bumps that have been deposited onto chip pads.", "The solder bumps are deposited on the chip pads on the top side of the wafer during the final wafer processing step.", "In order to mount the chip to external circuitry (e.g., a circuit board or another chip or wafer), it is flipped over so that its top side faces down, and aligned so that its pads align with matching pads on the external circuit, and then the solder is reflowed to complete the interconnect.", "This is in contrast to wire bonding, in which the chip is mounted upright and wires are used to interconnect the chip pads to external circuitry.", "Still referring to FIG.", "1, the photonics chip 10 can be mounted onto polymer spacers 25, which are positioned between the photonics chip 10 and the interposer 15.The interposer 15 can be, for example, a glass interposer or SOI substrate as examples.", "One or more optical fibers 30 are optically coupled to the photonics chip 10 and more specifically to the waveguide structure.", "In more specific embodiments, the optical fibers 30 are coupled to a Si waveguide structure.", "An optical cavity/transmission critical area represented by reference numeral 35 is formed between the interposer 15 and photonics chip 10.In embodiments, the optical cavity/transmission critical area includes an optical grating above and below the cavity 35 in order to transmit light between waveguide structures.", "The optical gratings are represented by reference numerals 80, 110 and are more clearly shown in FIG.", "4, for example.", "In embodiments, the cavity 35 is surrounded or enclosed using, at least in part, a barrier structure 40.As should be understood, the interposer 15 can include a vertical coupling using optical grating within a critical transmission area, as shown more clearly in FIG.", "4.As described herein, the barrier structure 40 is composed of a low or no-flow underfill material, e.g., polymer material, in any of the aspects described herein.", "In embodiments, the underfill material 40 is a high viscous polymer material that has minimal or does not flow during attachment of the interposer 15 to the photonics chip 10.Accordingly, the underfill material 40 can be applied to the surface of either the interposer 15 or the photonics chip 10 prior to the joining process.", "Once the underfill material 40 is applied, the interposer 15 can be joined to the photonics chip 10 by a press fitting process.", "In embodiments, the underfill material 40 will have a CTE that substantially matches to the CTE of both the interposer 15 and/or the photonics chip 10.After the joining process, the underfill material 40 can be cured at a low temperature, e.g., 150° C. for about 1 hour to 2 hours.", "A UV curing is also contemplated herein.", "For example, optical epoxy based UVs have a cationic curing reaction.", "This kind of system can exhibit a lower shrinkage (1-2%) and higher temperature resistance.", "In embodiments, this cure process will attach the interposer 15 to the photonics chip 10 and will also result in the formation of the cavity 35 surrounding the optical transmission area, e.g., optical grating of the photonics chip 10 and interposer 15.Following the cure or after other processes, the solder 20 can be reflowed to complete the attachment of the interposer 15 to the photonics chip 10.In embodiments, the optical fibers 30 can be coupled to the waveguide structure, followed by the cavity 35 being filled with a low viscosity optical epoxy material 45 by capillary flow techniques, e.g., injection or jet dispensing of the optical epoxy material 45 into the cavity 35.In contemplated embodiments, the optical epoxy material 45 can include materials manufactured by, e.g., Polytec PT.", "More specifically, the low viscosity optical epoxy material 45 can be dispensed next to the cavity 35, spreading with capillary force caused by a narrow gap between the photonics chip 10 and the interposer 15.Advantageously, in embodiments, the underfill material 40 will provide a boundary for maintaining the optical epoxy material 45 within the confined area of the optical transmission region (e.g., optical grating couplers) during this capillary flow process.", "The remaining spaces, e.g., interstitial areas between the solder balls 20, can then be filled with conventional underfill material 47, through similar injection or jet dispensing methods, to provide mechanical stability to the die (photonics chip) 10 mounted on the interposer 15.The underfill material 47 should preferably have a coefficient of the al expansion (CTE) approximately equal to the solder upon curing and/or the photonics chip 10 and the interposer 15, and serves to distribute the stresses that d otherwise be concentrated on localized regions of the solder connections 20.The underfill material 47 and the optical epoxy material 45 can be cured using conventional processes known to those of skill in the art.", "By way of more specific example and still referring to FIG.", "1, the cavity 35 surrounds the optical transmission area, e.g., localized to the optical gratings, and can include dimensions based on the structural dimensions (e.g., width, height and length) of the optical gratings, as well as other design and engineering criteria.", "For example, the cavity 35 can be dimensioned to accommodate any type of waveguide structure or optical gratings used in photonics chip packaging.", "Specifically, the underfill material 40 can be about 200 microns to about 300 microns wide, surrounding the optical transmission area, e.g., forming cavity 35.The height of the underfill material 40 can be about 85 microns to about 90 microns, in one illustrative non-limiting example.", "Moreover, although it is preferred that the underfill material 40 surrounds the entirety of the cavity 35, in aspects provided herein the underfill material 40 need only be dimensioned and structured to prevent the low viscosity optical epoxy material 45 from diffusing out of the cavity 35, potentially degrading the structural integrity of the photonics chip due to CTE mismatch with the photonics chip 10 and/or the interposer 15.In further embodiments, the height of the underfill material 40 can extend completely between the facing surfaces of the photonics chip 10 and the interposer 15.In alternative aspects, the height of the underfill material 40 can extend partially between the facing surfaces of the photonics chip 10 and the interposer 15, leaving a space between the underfill material 40 and the interposer 15.In this embodiment, the reflow of the solder 45 will provide the initial connection between the interposer 15 and the photonics chip 10, while the space can be dimensioned to prevent the low viscosity optical epoxy material 45 from diffusing out of the cavity 35, as based on the viscosity of the optical epoxy material 45.For example, the dimensions of the space will have such a height as to prevent the optical epoxy material 45 from expanding beyond the cavity 35 and/or degrading structural integrating of the waveguide structure.", "FIG.", "2 shows a top view of a photonics chip positioned on an interposer with optical fibers in accordance with additional aspects of the present disclosure.", "Specifically, in the structure 5′ of FIG.", "2, the optical epoxy material 45′ can be applied in the localized area 35′, prior to the joining of the interposer 15 to the photonics chip 10.In this aspect, the optical epoxy material 45′ will exhibit low or no-flow characteristics, e.g., exhibit high viscosity characteristics such that the optical epoxy material 45′ will remain in the local area 35′, e.g., area of the optical transmission, during the joining process.", "Also, in this aspect, due to the flow characteristics of the optical epoxy material 45′, the use of the underfill material 40 shown in FIG.", "1 can be eliminated.", "In contemplated embodiments, the optical epoxy material 45′ can include materials manufactured by, e.g., Polytec PT.", "In embodiments shown in FIG.", "2, the optical epoxy material 45′ is applied to the surface of either the interposer 15 or the photonics chip 10, which can then be joined together by a press fitting process.", "Once joined together or after other processes, the solder 20 can be reflowed to complete the attachment of the interposer 15 to the photonics chip 10.The remaining spaces, e.g., interstitial areas between the solder balls 20, can then be filled with conventional underfill material 47, as described herein, to provide mechanical stability to the photonics chip 10 mounted on the interposer 15.The underfill material 47 and the optical epoxy material 45′ can be cured using conventional processes known to those of skill in the art.", "In alternative embodiments, the underfill material 47 can be applied prior to the joining of the interposer 15 to the photonics chip 10, by applying the underfill material 47 to surface of either the interposer 15 or the photonics chip 10.Once the underfill material 47 and the optical epoxy material 45′ are applied to the surface of either the interposer 15 or the photonics chip 10, the interposer 15 can be attached to the photonics chip 10 by a press fitting operation followed by a reflow process of the solder connections 20.In alternative embodiments as also represented by FIG.", "2, the optical epoxy material 45′ can be a low viscosity epoxy material applied by a capillary flow process, e.g., injection or jet dispensing processes, after the interposer 15 is attached to the photonics chip 10 by a reflow processes of the solder 45.In this aspect, the optical epoxy material 45′ will be injected into the local area 35′, e.g., area of the optical transmission; whereas, the remaining spaces, e.g., interstitial areas between the solder balls 20, can then be filled with conventional underfill material 47.As to the latter point, following the injection of the optical epoxy material 45′, the interstitial areas between the solder balls 20 can be filled with conventional underfill material 47 to provide mechanical stability to the photonics chip 10 mounted on the interposer 15.In this aspect, the optical epoxy material 45′ will be injected at the local area 35; whereas, the conventional underfill material 47 can be injected from an opposing side of the structure 5′ (as designated by the arrow labeled “X”).", "Also, the conventional underfill material 47 will be applied by a measured timing in order to ensure that the conventional underfill material 47 does not creep into the localized optical area 35′.", "The underfill material 47 and the optical epoxy material 45′ can be cured using conventional processes known to those of skill in the art as described already herein.", "FIG.", "3 shows a cross-sectional view of the photonics chip package in accordance with aspects of the present disclosure.", "As shown in FIG.", "3, the photonics chip 10 is mounted on the interposer 15, with the optical fibers 30 providing optical transmission into separate cavities 35 (e.g., optical cavity) formed between the photonics chip 10 and interposer 15.In embodiments, the cavity 35 is surrounded by the underfill material 40.For illustrative purposes, the cavity 35 is not filled with the optical epoxy material.", "In embodiments, the photonics chip 10 can include several layers including a semiconductor substrate 10a, an insulator layer 10b (buried oxide layer (BOX)) and back end of the line (BEOL) metal fill layers 10c with guardring structures 10d formed therein.", "The photonics chip 10 further includes the plurality of solder connections represented at reference numeral 20.The interposer 15 can include several layers including, e.g., a passivation layer 15a, a polymer layer 15b, a glass interposer layer 15c, a polymer layer 15d, a copper layer 15e and a passivation layer 15f.", "The interposer 15 can further include a conductive (metal) via connection 15g as should be understood by those of skill in the art.", "It should be understood by those of skill in the art that the photonics chip 10 and interposer 15 can include other layers depending on the design and engineering considerations for the particular application as described herein.", "FIG.", "4 shows a cross-sectional view of an alternative photonics chip and interposer with optical fibers in accordance with aspects of the present disclosure.", "In this embodiment, the interposer 15 includes a vertical coupling using optical grating within a transmission area, e.g., cavity 35, surrounded by the underfill material 40.As shown in FIG.", "4, the photonics chip 10 is mounted on the interposer 15, with the optical fibers 30 coupled to a Si waveguide structure 50.In more specific embodiments, the photonics structure (e.g., photonics chip) 10 is a silicon photonics chip.", "The silicon photonics chip 10 includes a substrate assembly (e.g., silicon-on-insulator (SOI) (handle wafer)) comprising a plurality of CMOS devices 65 formed on the substrate 70, and a silicon waveguide 75 disposed/formed on the substrate 70.A grated optical coupler 80 optically couples the silicon waveguide 75 to an optical signal (e.g., optical fiber).", "More specifically, as should be understood by those of skill in the art, the grated optical coupler 80 is used to redirect light in a waveguide into an optical detector external to the waveguide.", "In embodiments, the grated optical coupler 80 can redirect light into the grated optical coupler 110 of the interposer, or vice versa.", "Light that has been traveling transversely through the waveguide by reflecting off the waveguide's inner surface at shallow angles may be redirected so that it strikes the inner surface of the waveguide at a sharper angle that is greater than the critical angle of incidence, thus allowing the light to escape through the surface.", "After escaping, the light may impinge upon a detector (e.g., CMOS devices 65).", "The detected light may then be used for various purposes, such as to receive an encoded communications signal that was transmitted through the waveguide.", "A buried oxide layer (BOX) 72 is formed on the substrate 70 and electrically insulates the silicon waveguide 75.A plurality of patterned electrical interconnects 85 are provided to make electrical connections to BEOL structures (CMOS devices) 65, and a dielectric layer 90 underlying the BOX layer 65 insulates the plurality of electrical interconnects 85 and CMOS devices 65.A plurality of solder structures (C4 balls) 20 are formed in electrical contact with the CMOS devices 65 and other structures, e.g., waveguide structures.", "Still referring to FIG.", "4, a second substrate assembly, e.g., interposer 15, is coupled to the plurality of solder structures 20, which includes a silicon interposer 100, a BOX layer 105 underlying silicon interposer 100, a silicon waveguide structure 50 formed on the BOX layer 105 and a plurality of BEOL structures generally represented at reference numeral 115.A grated optical coupler 110 overlies the waveguide structure 50 to couple the optical signal, e.g., couples the optical transmission with the grated optical coupler 80.The interposer 15 further includes a plurality of electrical contacts 120 connecting photonics chip 10 and the interposer 15.An optical epoxy 45 is deposited in the cavity 35 formed between the substrates, e.g., photonics chip 10 and interposer 15, directly overlying the grated optical coupler 80 and directly underlying the grated optical coupler 110.As further shown in this view, the underfill material 40 extends fully between facing surfaces of the photonics chip 10 and the interposer 15, and surrounding the cavity 35.That is, the underfill material 40 contacts the facing surface of both the photonics chip 10 and the interposer 15.In alternative embodiments, the underfill material 40 can also include a space as represented by dashed line 200.As should now be understood by those of skill in the art, in embodiments, the optical epoxy material 45 (or 45′) is provided in a localized area to span a gap (cavity 35) between the grated optical couplers 80, 110.The conventional underfill material can then fill remaining regions, outside of the optical region.", "In embodiments, the optical epoxy material 45 (or 45′) can be applied in different processes during different steps of fabrication according to aspects described herein.", "For example, the optical epoxy material 45 (or 45′) is first applied in the localized regions, followed by attachment of the die (photonics chip) 10 and interposer 15 followed by conventional capillary flow underfill material being applied.", "In alternative embodiments, the optical epoxy material 45 (or 45′) is applied in localized regions with the conventional underfill material being applied to other regions, followed by attachment of the photonics chip 10 and interposer 15.In yet additional embodiments, the photonics chip 10 and interposer 15 can be attached by solder reflow processes, followed by capillary flow of the optical epoxy material 45 in the localized regions, e.g., regions of the optical transmission, with capillary flow of the conventional underfill material in remaining regions.", "The method(s) as described above is used in the fabrication of integrated circuit chips.", "The resulting integrated circuit chips can be distributed by the fabricator in raw wafer form (that is, as a single wafer that has multiple unpackaged chips), as a bare die, or in a packaged form.", "In the latter case the chip is mounted in a single chip package (such as a plastic carrier, with leads that are affixed to a motherboard or other higher level carrier) or in a multichip package (such as a ceramic carrier that has either or both surface interconnections or buried interconnections).", "In any case the chip is then integrated with other chips, discrete circuit elements, and/or other signal processing devices as part of either (a) an intermediate product, such as a motherboard, or (b) an end product.", "The end product can be any product that includes integrated circuit chips, ranging from toys and other low-end applications to advanced computer products having a display, a keyboard or other input device, and a central processor.", "The descriptions of the various embodiments of the present disclosure have been presented for purposes of illustration, but are not intended to be exhaustive or limited to the embodiments disclosed.", "Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments.", "The terminology used herein was chosen to best explain the principles of the embodiments, the practical application or technical improvement over technologies found in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein." ] ]
Patent_15874210
[ [ "SEED CRYSTAL HOLDER, CRYSTAL GROWING DEVICE, AND CRYSTAL GROWING METHOD", "A seed crystal holder according to the present invention for growing a crystal by a solution method, and that includes a seed crystal made of silicon carbide; a holding member above the seed crystal; a bonding agent configured to fix the seed crystal and the holding member; and a sheet member made of carbon which is interposed in the bonding agent in a thickness direction, and which has an outer periphery smaller than an outer periphery of the seed crystal in a plan view." ], [ "1.A seed crystal holder for growing a crystal by a solution method, comprising: a seed crystal made of silicon carbide; a holding member above the seed crystal; a bonding agent configured to fix the seed crystal and the holding member; and a sheet member made of carbon which is interposed in the bonding agent in a thickness direction, wherein the sheet member comprises a through hole in the thickness direction, and an inside of the through hole is filled with a part of the bonding agent.", "2.The seed crystal holder according to claim 1, wherein the sheet member has an outer periphery larger than an outer periphery of the holding member in a plan view.", "3.The seed crystal holder according to claim 1, wherein the bonding agent comprises a cavity constituted with the seed crystal.", "4.The seed crystal holder according to claim 3, wherein the bonding agent further comprises a pore thereinside, and the cavity is larger than the pore, the pore being located between the sheet member and the holding member.", "5.The seed crystal holder according to claim 1, wherein the sheet member further comprises a plurality of through holes, and the number of the plurality of through holes increases as going to a center of the sheet member from an outer circumference.", "6.The seed crystal holder according to claim 1, wherein a part of the bonding agent covers a side surface of the sheet member.", "7.The seed crystal holder according to claim 1, wherein the sheet member includes carbon particles and silicon as a component.", "8.The seed crystal holder according to claim 1, wherein the sheet member includes silicon in a state of silicon carbide.", "9.The seed crystal holder according to claim 1, wherein the bonding agent includes silicon as a component.", "10.The seed crystal holder according to claim 9, wherein the silicon included in the part of the bonding agent between the sheet member and the holding member is more than the silicon included in the part of the bonding agent between the sheet member and the seed crystal.", "11.A crystal growing device, comprising: a melting crucible that keeps a solution for growing a crystal; and the seed crystal holder according to claim 1.12.A crystal growing method, comprising: a first preparation step of preparing a melting crucible and a solution of silicon including carbon which is kept in the melting crucible; a second preparation step of preparing the seed crystal holder according to claim 1; and a growing step of bringing a lower surface of the seed crystal in contact with the solution kept in the melting crucible, and then raising a holding member upwardly, so as to grow a silicon carbide crystal from the solution on the lower surface of the seed crystal.", "13.The crystal growing method according to claim 12, wherein the second preparation step is a step of preparing the seed crystal holder using a bonding agent including carbon particles as the bonding agent, and further comprising a step of immersing a part of the bonding agent together with the seed crystal in the solution kept in the melting crucible between the second preparation step and the growing step.", "14.The crystal growing method according to claim 13, further comprising a step of immersing the sheet member together with the seed crystal in the solution kept in the melting crucible between the second preparation step and the growing step." ], [ "<SOH> BACKGROUND ART <EOH>As a crystal which currently attracts attention, there is silicon carbide (SiC) which is a compound of carbon and silicon.", "The silicon carbide has an advantage of, for example, a good voltage endurance characteristic, or the like.", "In a method of growing the silicon carbide crystal, there are, for example, a sublimation method, a solution method, and the like.", "The method of growing the silicon carbide crystal by the solution method is disclosed, for example, in Japanese Unexamined Patent Application Publication No.", "2000-264790." ], [ "<SOH> SUMMARY OF INVENTION <EOH>In research and development for growing a crystal made of silicon carbide, it is difficult to fix a seed crystal and a crystal grown on a lower surface of the seed crystal to a holding member.", "An object of the present invention is suggested in view of the circumstances described above, and is suggested to provide a seed crystal holder that can stably fix the seed crystal to the holding member, and a crystal growing device and a crystal growing method using the seed crystal holder.", "A seed crystal holder according to the present invention is used for growing a crystal by a solution method, and includes a seed crystal made of silicon carbide; a holding member above the seed crystal; a bonding agent fixing the seed crystal and the holding member; and a sheet member made of carbon which is interposed in the bonding agent in a thickness direction, and which has an outer periphery smaller than an outer periphery of the seed crystal in a plan view.", "A crystal growing device according to the present invention includes a melting crucible that keeps a solution for growing a crystal; and the seed crystal holder described above.", "A crystal growing method according to the present invention includes a first preparation step of preparing a melting crucible and a solution of silicon including carbon which is kept in the melting crucible; a second preparation step of preparing the seed crystal holder described above; and a growing step of bringing a lower surface of the seed crystal in contact with the solution kept in the melting crucible, raising a holding member upwardly, and growing a silicon carbide crystal from the solution on the lower surface of the seed crystal.", "In the seed crystal holder according to the present invention, since the sheet member is interposed in the bonding agent, it is possible to alleviate stress inherent in the bonding agent.", "Therefore, the bonding agent is not easily peeled off from the seed crystal or the holding member.", "Further, in the crystal growing device according to the present invention, since the seed crystal holder described above is used, it is possible to cause the seed crystal not to be easily peeled off from the bonding agent.", "Therefore, the seed crystal is not easily dropped while the crystal is grown, so that the crystal on the lower surface of the seed crystal can grow for a long time.", "As a result, it is possible to cause the crystal to be grown on the lower surface of the seed crystal to be large.", "In addition, in the crystal growing method according to the present invention, it is possible to cause the seed crystal not to be easily peeled off from the bonding agent by using the seed crystal holder described above.", "Therefore, it is possible to grow the crystal on the lower surface of the seed crystal to be long (large) in the thickness direction." ], [ "The present application is a continuation of U.S. application Ser.", "No.", "14/375,783 filed on Jul.", "30, 2014 which is a National Phase entry of International Application No.", "PCT/JP2013/052091, filed on Jan. 30, 2013, which claims the benefit of Japanese Application No.", "2012-016382, filed on Jan. 30, 2012.The contents of the above applications are incorporated by reference herein in their entirety.", "TECHNICAL FIELD The present invention relates to a seed crystal holder in which a seed crystal is joined to a holding member, a crystal growing device using the seed crystal holder, and a crystal growing method of growing a crystal by using the seed crystal holder.", "BACKGROUND ART As a crystal which currently attracts attention, there is silicon carbide (SiC) which is a compound of carbon and silicon.", "The silicon carbide has an advantage of, for example, a good voltage endurance characteristic, or the like.", "In a method of growing the silicon carbide crystal, there are, for example, a sublimation method, a solution method, and the like.", "The method of growing the silicon carbide crystal by the solution method is disclosed, for example, in Japanese Unexamined Patent Application Publication No.", "2000-264790.SUMMARY OF INVENTION In research and development for growing a crystal made of silicon carbide, it is difficult to fix a seed crystal and a crystal grown on a lower surface of the seed crystal to a holding member.", "An object of the present invention is suggested in view of the circumstances described above, and is suggested to provide a seed crystal holder that can stably fix the seed crystal to the holding member, and a crystal growing device and a crystal growing method using the seed crystal holder.", "A seed crystal holder according to the present invention is used for growing a crystal by a solution method, and includes a seed crystal made of silicon carbide; a holding member above the seed crystal; a bonding agent fixing the seed crystal and the holding member; and a sheet member made of carbon which is interposed in the bonding agent in a thickness direction, and which has an outer periphery smaller than an outer periphery of the seed crystal in a plan view.", "A crystal growing device according to the present invention includes a melting crucible that keeps a solution for growing a crystal; and the seed crystal holder described above.", "A crystal growing method according to the present invention includes a first preparation step of preparing a melting crucible and a solution of silicon including carbon which is kept in the melting crucible; a second preparation step of preparing the seed crystal holder described above; and a growing step of bringing a lower surface of the seed crystal in contact with the solution kept in the melting crucible, raising a holding member upwardly, and growing a silicon carbide crystal from the solution on the lower surface of the seed crystal.", "In the seed crystal holder according to the present invention, since the sheet member is interposed in the bonding agent, it is possible to alleviate stress inherent in the bonding agent.", "Therefore, the bonding agent is not easily peeled off from the seed crystal or the holding member.", "Further, in the crystal growing device according to the present invention, since the seed crystal holder described above is used, it is possible to cause the seed crystal not to be easily peeled off from the bonding agent.", "Therefore, the seed crystal is not easily dropped while the crystal is grown, so that the crystal on the lower surface of the seed crystal can grow for a long time.", "As a result, it is possible to cause the crystal to be grown on the lower surface of the seed crystal to be large.", "In addition, in the crystal growing method according to the present invention, it is possible to cause the seed crystal not to be easily peeled off from the bonding agent by using the seed crystal holder described above.", "Therefore, it is possible to grow the crystal on the lower surface of the seed crystal to be long (large) in the thickness direction.", "BRIEF DESCRIPTION OF DRAWINGS FIG.", "1 is a cross-sectional view illustrating an exemplary embodiment of a crystal growing device according to an embodiment of the present invention; FIGS.", "2A and 2B are diagrams illustrating a seed crystal holder according to the embodiment of the present invention, wherein FIG.", "2A is a cross-sectional view in which a part of the seed crystal holder is enlarged, and FIG.", "2B is a plan view illustrating the seed crystal holder viewed from above in a see-through manner; FIG.", "3 is a diagram illustrating a seed crystal holder according to the related art, and is an enlarged cross-sectional view illustrating an enlarged part of the seed crystal holder; FIG.", "4 is a diagram illustrating the seed crystal holder of FIGS.", "2A and 2B, and is an enlarged cross-sectional view illustrating the enlarged seed crystal holder; FIGS.", "5A and 5B are diagrams illustrating a modification of the seed crystal holder of FIGS.", "2A and 2B, wherein FIG.", "5A is a cross-sectional view in which a part of the seed crystal holder is enlarged, and FIG.", "5B is a plan view illustrating the seed crystal holder viewed from above in a see-through manner; FIG.", "6 is a cross-sectional view illustrating an enlarged part of the seed crystal holder of FIGS.", "5A and 5B; FIG.", "7 is a diagram illustrating a modification of the seed crystal holder of FIGS.", "2A and 2B, and is a plan view illustrating the modification viewed from above in a see-through manner; FIG.", "8 is a diagram illustrating a modification of the seed crystal holder of FIGS.", "2A and 2B, and is a cross-sectional view illustrating an enlarged part of the modification; FIG.", "9 is a diagram illustrating a modification of the seed crystal holder of FIGS.", "2A and 2B, and is a cross-sectional view illustrating an enlarged part of the modification; FIG.", "10 is a diagram illustrating a modification of the seed crystal holder of FIGS.", "2A and 2B, and is a cross-sectional view illustrating an enlarged part of the modification; FIG.", "11 is a diagram illustrating a modification of the seed crystal holder of FIGS.", "2A and 2B, and is a cross-sectional view illustrating an enlarged part of the modification; FIG.", "12 is a diagram illustrating a modification of the seed crystal holder of FIGS.", "2A and 2B, and is a cross-sectional view illustrating an enlarged part of the modification; FIG.", "13 is a diagram illustrating a sheet member used in the modification of the seed crystal holder of FIGS.", "2A and 2B, and is a plan view illustrating the sheet member viewed from above in a plan view; FIG.", "14 is a diagram illustrating a modification of the seed crystal holder of FIGS.", "2A and 2B, and is a cross-sectional view illustrating an enlarged part of a seed crystal holding member formed by using the sheet member illustrated in FIG.", "11; and FIG.", "15 is a diagram illustrating a modification of the seed crystal holder of FIGS.", "2A and 2B, and is a cross-sectional view illustrating an enlarged part of the modification.", "DESCRIPTION OF EMBODIMENTS Embodiments of a seed crystal holder, a crystal growing device, and a crystal growing method according to the present invention are described with reference to the drawings.", "A seed crystal holder 1 includes a seed crystal 2, a sheet member 3, a bonding agent 4, and a holding member 5.The seed crystal holder 1 is used in a crystal growing device 6 as illustrated in FIG.", "1.First, the crystal growing device 6 is described.", "<Crystal Growing Device> A melting crucible 7 is disposed in a melting crucible container 8.The melting crucible container 8 keeps the melting crucible 7.A lagging material 9 is disposed between the melting crucible container 8 and the melting crucible 7.The lagging material 9 encloses the circumference of the melting crucible 7.The lagging material 9 suppresses the heat radiation from the melting crucible 7, and contributes the temperature of the melting crucible 7 to be stably maintained.", "The melting crucible 7 functions as a container that causes raw materials of silicon carbide single crystal to be grown to be melted inside.", "According to the present embodiment, in the melting crucible 7, melted silicon is used as a solvent, and carbon is dissolved in the solvent to be accumulated as a solution 10.According to the present embodiment, a solution method is used, and a crystal is grown by causing the inside of the melting crucible 7 to be close to the thermal equilibrium.", "The melting crucible 7 is heated by a heating mechanism 11.The heating mechanism 11 according to the present embodiment uses an induction heating scheme of heating the melting crucible 7 by electromagnetic induction.", "The heating mechanism 11 includes coils 12 and an AC power supply 13.The melting crucible 7 is configured with a material having, for example, carbon (graphite) as a main component.", "The solution 10 is kept in the melting crucible 7.The solution 10 is obtained by dissolving carbon that configures the silicon carbide crystal to be grown on a lower surface 2B of the seed crystal 2 in the solution of silicon that configures silicon carbide crystal as well.", "The solubility of an element to be a solute increases as the temperature of the element to be a solvent becomes high.", "Therefore, the temperature of the solution 10 that causes many solutes to be dissolved in the solvent under the high temperature decreases near the seed crystal 2 by decreasing the temperature of the lower surface 2B of the seed crystal 2 to be slightly lower than the temperature of the solution 10, and the solutes are precipitated on the basis of the thermal equilibrium.", "The silicon carbide crystal can be grown on the lower surface 2B of the seed crystal 2 by using the precipitation due to the thermal equilibrium.", "The coils 12 are formed with conductors, and are wound to enclose the circumference of the melting crucible 7.The AC power supply 13 causes alternating currents to flow to the coils 12.The heating time of a set temperature can be adjusted by adjusting the amount of the alternating currents that flow to the coils 12.According to the present embodiment, the melting crucible 7 is heated by the induction heating scheme.", "Further, the solution 10 may generate heat by causing the induced current to flow to the solution 10 itself by the electromagnetic field.", "When heat is generated in the solution 10 itself in this manner, the melting crucible 7 itself may not be caused to generate heat.", "The seed crystal 2 is brought into contact with the solution 10 by a conveyance mechanism 14.The conveyance mechanism 14 also can transfer out the crystal grown on the lower surface 2B of the seed crystal 2.The conveyance mechanism 14 includes the holding member 5 and a power source 15.The seed crystal 2 and the crystal grown on the lower surface 2B of the seed crystal 2 are transferred in and out through the holding member 5.The seed crystal 2 is provided on a lower end surface 5A of the holding member 5, and movement of the holding member 5 is controlled by the power source 15 in upper and lower directions (directions D1 and D2).", "According to the present embodiment, the direction D1 means the lower direction in the physical space, and the direction D2 means the upper direction in the physical space.", "In the crystal growing device 6, the AC power supply 13 of the heating mechanism 11 and the power source 15 of the conveyance mechanism 14 are connected to a control unit 16 to be controlled.", "That is, the crystal growing device 6 is controlled by interlocking the heating and the temperature control of the solution 10 and the transfer of the seed crystal 2, by the control unit 16.The control unit 16 includes a central processing unit and a storage unit such as a memory, and is configured with, for example, a well-known computer.", "The holding member 5 of the seed crystal holder 1 is provided in the conveyance mechanism 14 of the crystal growing device 6 according to the present embodiment, as described below.", "Then, the lower surface 2B of the seed crystal 2 which is fixed on the lower end surface 5A of the holding member 5 is brought into contact with the solution 10, so that the crystal can be grown on the lower surface 2B.", "The crystal growing device 6 according to the present embodiment grows the crystal by providing the seed crystal holder 1 in the conveyance mechanism 14 to be described below.", "The seed crystal holder 1 causes the bonding agent 4 not to be easily peeled off from the seed crystal 2 or the holding member 4.Therefore, it is possible to cause the seed crystal 2 not to be easily dropped while the crystal is grown, so that the crystal on the lower surface 2B of the seed crystal 2 can stably grow for a long time.", "Therefore, the crystal growing device 6 can cause the crystal to be grown on the lower surface 2B of the seed crystal 2 to be large in the thickness direction.", "<Seed Crystal Holder> Next, the seed crystal holder 1 according to the present embodiment of the present invention is described in detail as follows.", "The seed crystal holder 1 according to the present embodiment is the seed crystal holder 1 used for growing a crystal by the solution method, and includes the seed crystal 2 made of silicon carbide, the holding member 5 on the seed crystal 2, the bonding agent 4 that fixes the seed crystal 2 and the holding member 5, and the sheet member 3 made of carbon which is interposed in the bonding agent 4 in the thickness direction and has an outer periphery smaller than the outer periphery of the seed crystal 2 in the plan view.", "The seed crystal 2 is configured with the silicon carbide crystal.", "The silicon carbide crystal of the seed crystal 2 can use, for example, the silicon carbide single crystal.", "The thickness of the seed crystal 2 can be set to be, for example, from 0.1 mm to 10 mm.", "The seed crystal 2 can be provided so that the external form in the plan view has, for example, a polygonal shape or a circular shape.", "The horizontal width dimension of the seed crystal 2 can be set to be, for example, from 5 mm to 20 cm.", "The lower end surface 5A of the holding member 5 is fixed to an upper surface 2A of the seed crystal 2 through the bonding agent 4, as illustrated in FIG.", "2A.", "That is, the holding member 5 is positioned above the seed crystal 2 with the bonding agent 4 interposed therebetween.", "Here, FIG.", "2A is a cross-sectional view illustrating an enlarged part of the seed crystal holder 1 including the seed crystal 2, the bonding agent 4, and the holding member 5.The holding member 5 may include the lower end surface 5A.", "The lower end surface 5A has a plan view of, for example, a polygonal shape such as a square, or a circular shape.", "The holding member 5 has a cubic shape of, for example, a polygonal column shape, a rod shape such as a cylindrical shape, or a rectangular parallelepiped shape.", "It is possible to appropriately select a material for the holding member 5, and the holding member 5 may be configured with a material including, for example, an oxide represented by zirconium oxide or magnesium oxide, or carbon, as a main component.", "The holding member 5 can use, for example, a polycrystalline substance of carbon, or a burned substance obtained by firing carbon.", "If the holding member 5 is configured with the polycrystalline substance or the sintered substance of carbon, it is possible to increase the porosity in the holding member 5.When the porosity of the holding member 5 is increased, it is possible to release gas generated in the bonding agent 4 from the holding member 5, and to maintain the bonding strength with the bonding agent 4 by suppressing bubbles or the like generated in the bonding agent 4.The area of the lower end surface 5A of the holding member 5 may be greater than that of the upper surface 2A of the seed crystal 2, may be identical to that of the upper surface 2A of the seed crystal 2 in size, and may be smaller than that of the upper surface 2A of the seed crystal 2.According to the present embodiment, the area of the lower end surface 5A of the holding member 5 is smaller than that of the upper surface 2A of the seed crystal 2.Further, when the area of the lower end surface 5A of the holding member 5 is equal to or greater than that of the upper surface 2A of the seed crystal 2, it is possible to cause the heat of the seed crystal 2 to be easily radiated from the holding member 5 throughout the entire upper surface 2A of the seed crystal 2.The bonding agent 4 fixes the seed crystal 2 and the holding member 5.The bonding agent 4 is disposed to be interposed between the upper surface 2A of the seed crystal 2 and the lower end surface 5A of the holding member 5.A material for the bonding agent 4 can be appropriately set according to the material of the seed crystal 2 and the material of the holding member 5.It is possible to use, for example, a ceramic bonding agent including aluminum oxide, magnesium oxide, zirconium oxide, or the like or a carbon bonding agent made from carbon, as the bonding agent 4.The bonding agents 4 interpose the sheet member 3 in the thickness direction.", "Here, in the description below, among the bonding agent 4, a part between the sheet member 3 and the holding member 5 may be called the bonding agent 4a, and a part between the sheet member 3 and the seed crystal 2 may be called the bonding agent 4b, in particular.", "The sheet member 3 may be fixed to the lower end surface 5A of the holding member 5 through the bonding agent 4a, and also may be fixed to the upper surface 2A of the seed crystal 2 through the bonding agent 4b.", "The sheet member 3 has an outer periphery smaller than that of the seed crystal 2 in the plan view.", "The sheet member 3 may be slightly smaller than the outer periphery of the seed crystal 2.Specifically, the sheet member 3 is provided so that the outer periphery is smaller than the outer periphery of the seed crystal 2, for example, in the range from 1 μm to 1 cm in the plan view.", "The sheet member 3 can be provided so that the external form in the plan view has, for example, a polygonal shape or a circular shape.", "Further, the size of the sheet member 3 may be appropriately set, but, for example, the size can be set to be equal to or greater than the area of the lower end surface 5A of the holding member 5, and to be equal to or less than the area of the upper surface 2A of the seed crystal 2.Further, there is no problem if the size of the sheet member 3 is smaller than the area of the lower end surface 5A of the holding member 5.The material of the sheet member 3 can be appropriately set according to the material of the bonding agent 4.When stress is applied to the bonding agent 4, the sheet member 3 may use a material that can alleviate the stress.", "For example, the material may be set in consideration of an elastic modulus or the like appropriate for the material of the bonding agent 4.Specifically, a sheet-shaped member obtained by compressing graphite can be used as the sheet member 3.The sheet member 3 may be provided so that the thickness thereof is, for example, from 0.1 μm to 5 mm.", "According to the configuration described above, the seed crystal holder 1 is configured.", "Here, if the seed crystal holder 1 is used for growing the crystal by the solution method, the coefficient of thermal expansion of the bonding agent 4 is different from those of the seed crystal 2 and the holding member 5.Therefore, thermal stress is inherent in the bonding agent 4.The seed crystal holder according to the present embodiment includes the sheet member 3 interposed in the bonding agent 4 fixing the seed crystal 2 and the holding member 5 in the thickness direction.", "Therefore, since the sheet member 3 is elastically deformed according to the thermal stress inherent in the bonding agent 4, it is possible to decrease the thermal stress between the bonding agent 4 and the holding member 5 or between the bonding agent 4 and the seed crystal 2.As a result, the bonding agent 4 is easily peeled off from the seed crystal 2 or the holding member 5.Since the deformation of the seed crystal 2 in a surface direction is suppressed in this manner, it is possible to maintain the flatness of the lower surface 2B of the seed crystal 2.As a result, it is possible to suppress the generation of the dislocation or micropipe in the crystal to be grown on the lower surface 2B of the seed crystal 2.In addition, the sheet member 3 has the outer periphery smaller than the outer periphery of the seed crystal 2 in the plan view.", "Therefore, for example, when a bonding material in a step before the bonding agent 4 is solidified is coated, it is possible to cause the bonding material to easily enclose the side surfaces of the sheet member 3, and the bonding material is not easily adhered to the side surfaces of the seed crystal 2.As a result, it is possible to improve the quality of the crystal to be grown on the lower surface 2B of the seed crystal 2.Meanwhile, if the outer periphery of the sheet member is caused to be greater than that of the seed crystal, the bonding material is easily adhered to the side surfaces of the seed crystal.", "Therefore, when the silicon carbide crystal that causes the seed crystal to be brought into contact with the solution is grown, miscellaneous crystals are easily grown from a starting point of the bonding material adhered to the side surface of the seed crystal.", "As a result, the miscellaneous crystals disturb the crystal from growing so that, for example, it may not be possible to increase the size of the crystal.", "(Modification 1 of Seed Crystal Holder) When the carbon bonding agent is used as the bonding agent 4, it is possible to alleviate the thermal stress generated by the difference in the coefficients of thermal expansion of the bonding agent 4 and the sheet member 3.Therefore, the bonding agent 4 and the sheet member 3 are not easily peeled off from each other.", "Further, in the description below, the bonding agent 4 made with the carbon bonding agent may be simply called the carbon bonding agent 4′.", "A member made of carbon may be used as the holding member 5.When the holding member 5 made of carbon is used, the carbon bonding agent 4′ contains carbon.", "Therefore, the coefficient of thermal expansion of the holding member 5 can be close to that of the carbon bonding agent 4′.", "Accordingly, it is possible to cause the carbon bonding agent 4′ not to be easily peeled off from the holding member 5.As illustrated in FIG.", "3, a seed crystal holder 17 according to the related art fixes a seed crystal 18 to a holding member 20 through a carbon bonding agent 19.Therefore, since the carbon bonding agent 19 and the seed crystal 18 are different materials, the coefficients of thermal expansion thereof are different from each other.", "Accordingly, a thermal stress 21 is easily generated near the border between the carbon bonding agent 19 and the seed crystal 18.Therefore, a second thermal stress 22 caused by the thermal stress 21 generated near the seed crystal 18 is inherent in the bonding agent 19 in the thickness direction.", "As a result, bonding strength decreases on the border between the seed crystal 18 and the bonding agent 19, and the seed crystal 18 is easily peeled off.", "Therefore, it may not be possible to increase the size of the crystal to be grown on a lower surface 18B of the seed crystal 18.Meanwhile, as illustrated in FIG.", "4, with respect to the seed crystal holder 1 according to the modification, the sheet member 3 functions as a layer that alleviates the thermal stress generated between the bonding agent 4b and the bonding agent 4a.", "That is, since it is possible to alleviate the thermal stress in the bonding agent 4 by elastically deforming the sheet member 3, it is possible to decrease a thermal stress 23 to be smaller than the thermal stress 21 in the seed crystal holder 17 according to the related art, and it is possible to cause the seed crystal 2 not to be easily peeled off from the bonding agent 4.", "(Modification 2 of Seed Crystal Holder) As illustrated in FIGS.", "5A, 5B and 6, the sheet member 3 may include through holes 3a in the thickness direction.", "The through holes 3a can be set to have, for example, a polygonal shape such as a polygonal shape or a circular shape.", "The through holes 3a may penetrate in the thickness direction, or may be partially bent along the thickness direction.", "The sizes of the through holes 3a may be appropriately set according to the material of the bonding agent 4, the thickness of the sheet member 3, or the material of the holding member 5, but the sizes can be set to be, for example, from 0.5 mm to 1.5 cm.", "Further, the through holes 3a may be disposed to be overlapped with the holding member 5 in the plan view.", "The insides of the through holes 3a are filled with the bonding agent 4.The bonding agent 4 in the through holes 3a may be disposed so that the bonding agent 4a and the bonding agent 4b are connected to each other.", "That is, it is not required that the insides of the through holes 3a are fully filled with the bonding agent 4.When the crystal is grown by the solution method, as described above, it is possible to cause the crystal to be easily grown on a lower surface 2A of the seed crystal 2 by causing the temperature of the seed crystal 2 to be slightly lower than that of the solution 10.Therefore, when the heat of the seed crystal 2 is radiated from the holding member 5, the sheet member 3 has the through holes 3a, and it is possible to cause the heat to be easily conducted by the bonding agent 4 disposed in the through holes 3a.", "According to this, the temperature of the seed crystal 2 is effectively decreased.", "As a result, the seed crystal 2 is not easily peeled off from the bonding agent 4, and it is possible to cause the crystal to be easily grown on the lower surface 2B of the seed crystal 2 by improving the thermal conduction.", "Further, since the bonding agent 4 easily conducts heat, it is possible to alleviate the thermal stress generated in the bonding agent 4.According to the present modification, it is described that the sheet member 3 has the plurality of through holes 3a, but the sheet member 3 may have only one through hole 3a.", "When the sheet member 3 has only one through hole 3a, it is possible to adjust the thermal conduction of the bonding agent 4 by adjusting the size (diameter) and the plan view shape of the through hole 3a.", "Further, when the sheet member 3 has the plurality of through holes 3a, it is possible to adjust the thermal conduction of the bonding agent 4 from the seed crystal 2 to the holding member 5 by adjusting the sizes (diameters) of the through holes 3a, for example, to be small.", "(Modification 3 of Seed Crystal Holding Member) The sheet member 3 has the plurality of through holes 3a, and the number of through holes 3a may increase as it goes from the outer circumference to the center of the sheet member 3.The seed crystal holder 1 of the present modification is illustrated in FIG.", "7.Here, the outer circumference of the sheet member 3 refers to the outer circumference when the sheet member 3 is viewed in the planar manner, and the center refers to the center of the shape of the sheet member 3 when the sheet member 3 is viewed in the planar manner.", "The number of through holes 3a may increase as it goes from the outer circumference to the center of the sheet member 3.Specifically, a straight line is drawn from the outer circumference to the center, gaps between the neighboring through holes 3a among the through holes 3a through the straight line passes may decrease as it goes from the outer circumference to the center.", "In the sheet member 3, the through holes 3 disposed in this manner may be provided throughout the entire body, or only a part may be provided in this manner.", "According to the present modification, the description has been made with respect to the case in which the through holes 3a are disposed in this manner in a region in which the sheet member 3 is overlapped with the holding member 5 in the plan view, but the configuration is not limited to this.", "In the region in which the bonding agent 4 is overlapped with the holding member 5 in the plan view, since the distance from the external air increases as it goes toward the center, the temperature of the bonding agent 4 increases as it goes toward the center.", "Therefore, it is possible to increase the thermal conduction near the center by disposing more through holes 3a as it goes from the outer circumference to the center as described in the present modification.", "As a result, it is possible to suppress the generation of the thermal stress near the center of the bonding agent 4, and the seed crystal 2 is not easily peeled off from the bonding agent 4.", "(Modification 4 of Seed Crystal Holder) The bonding agent 4 may have cavities 4c between the bonding agent 4 and the seed crystal 2 as illustrated in FIG.", "8.Depending on size, the cavities 4c may be disposed between the sheet member 3 and the seed crystal 2.The cavities 4c may be set so that the width is, for example, from 1 μm to 2 mm.", "Since the materials of the seed crystal 2 and the bonding agent 4 are different from each other, the thermal stress is easily generated therebetween.", "Therefore, it is possible to alleviate the thermal stress by providing the cavities 4c constituted with the seed crystal 2.As a result, since it is possible to decrease the stress applied to the upper surface 2A of the seed crystal 2, it is possible to suppress the deformation of the crystal grown on the lower surface 2B of the seed crystal 2.Further, the bonding agent 4 has pores 4d inside as illustrated in FIG.", "9, and the cavities 4c are larger than the pores 4d present between the sheet member 3 and the holding member 5.That is, the cavities 4c are larger than the pores 4d present in the bonding agent 4a.", "Since the pores 4d are provided in the bonding agent 4, it is possible, for example, to decrease internal stress.", "Further, since the cavities 4c are larger than the pores 4d present in the bonding agent 4a, it is possible to maintain the bonding stress between the holding member 5 and the bonding agent 4d, and decrease the thermal stress applied on the upper surface 2A of the seed crystal 2.Further, some of the cavities 4c may exist in the sheet member 3 as illustrated in FIG.", "9.", "(Modification 5 of Seed Crystal Holder) The bonding agent 4 may be disposed so that a part thereof covers a side surface 3C of the sheet member 3 as illustrated in FIG.", "10.Specifically, the bonding agent 4b is disposed so that a part of the bonding agent 4b covers the side surface 3C of the sheet member 3.A part of the bonding agent 4b may cover only a part of the side surface 3C of the sheet member 3, or may cover the entire side surface 3C.", "When the bonding agent 4b is disposed so that a part of the bonding agent 4b covers the side surface 3C of the sheet member 3 in this manner, it is possible to fix a lower surface 3B of the sheet member 3 to the bonding agent 4 in the different surface direction.", "Therefore, it is possible to cause the bonding agent 4 not to be easily peeled off from the sheet member 3.Further, the bonding agent 4 may be provided to cover the side surface 3C of the sheet member 3 and extend to an upper surface 3A as illustrated in FIG.", "11.It is possible to further cause the bonding agent 4 not to be easily peeled off from the sheet member 3 by providing the bonding agent 4 so as to extend to the upper surface 3A of the sheet member 3 in this manner.", "(Modification 6 of Seed Crystal Holder) The sheet member 3 may include carbon particles and silicon as a component.", "Since the sheet member 3 includes silicon as a component, the thermal conductivity (149 [W·m−1·K−1]) of silicon is higher than the thermal conductivity (5 [w·m−1·K−1]) of carbon which is the component configuring the sheet member 3 in the thickness direction.", "Therefore, it is possible to improve the thermal conductivity of the sheet member 3.According to this, it is possible to improve the thermal conduction of the bonding agent 4.Further, the component of silicon in the sheet member 3 may include the state of silicon carbide.", "Since the thermal conductivity of the silicon carbide is from 150 [W·m−1·K−1] to 350 [W·m−1·K−1], it is possible to further improve the thermal conduction of the bonding agent 4.Further, it is possible to further improve the thermal conduction of the bonding agent 4 by combining the configuration of the present Modification 5 with Modification 2 and Modification 3.Further, silicon may be included as a component in the bonding agent 4.It is possible to improve the thermal conductivity of the bonding agent 4 by causing silicon to be included as a component in the bonding agent 4 in this manner.", "According to this, it is possible to improve the thermal conduction of the bonding agent 4.Further, with respect to the amount of the silicon component included in the bonding agent 4, as illustrated in FIG.", "12, the amount in the bonding agent 4a between the sheet member 3 and the holding member 5 may be different from that in the bonding agent 4b between the sheet member 3 and the seed crystal 2.Specifically, the bonding agent 4 may be set so that the amount of the silicon component in the bonding agent 4b is greater than that in the bonding agent 4a.", "In this manner, it is possible to decrease the difference of the bonding agent 4b in the coefficient of thermal expansion from the seed crystal 2 made of silicon carbide and to suppress the difference of the bonding agent 4a from the holding member 5 made of carbon in the coefficient of thermal expansion from increasing by causing the amount of silicon included in the bonding agent 4b to be greater than that in the bonding agent 4a.", "According to this, it is possible to cause the seed crystal 2 not to be easily peeled off from the bonding agent 4b, and to cause the holding member 5 not to be easily peeled off from the bonding agent 4a.", "When the carbon bonding agent 4′ is used as the bonding agent 4, it is possible to cause the aforementioned silicon to be included in the carbon bonding agent 4′ in a state of silicon carbide and to further decrease the difference of the carbon bonding agent 4′ from the seed crystal 2 in the coefficient of thermal expansion by causing silicon to be included in the carbon bonding agent 4′ as a component.", "Further, it is possible to favorably fix the holding member 5 to the seed crystal 2 by causing the amount of the silicon as a component included in the carbon bonding agent 4′a to be less than that in the carbon bonding agent 4′b.", "(Modification 7 of Seed Crystal Holder) As illustrated in FIG.", "13, the plurality of through holes 3a may be included throughout the entire sheet member 3, and some of the plurality of through holes 3a may be disposed in the region not overlapped with the holding member 5 in the plan view.", "Since the sheet member 3 has the through holes 3a in a region not overlapped with the holding member 5, it is possible to cause a part of the bonding agent 4b to extend to the upper surface 3A of the sheet member 3 as illustrated in FIG.", "14.Since the seed crystal holder 1 having bonding parts 4ab extending to the upper surface 3A of the sheet member 3 may be fixed by the bonding parts 4ab, it is possible to cause the bonding agent 4 not to be easily peeled off from the sheet member 3.The seed crystal holder 1 using the sheet member 3 having the bonding parts 4ab in this manner may be manufactured as follows.", "When the sheet member 3 is configured as illustrated in FIG.", "13, the bonding agent 4b is coated on the upper surface 2A of the seed crystal 2, the sheet member 3 is mounted on the bonding agent 4b, the bonding agent 4a is then coated on a part of the upper surface 3A of the sheet member 3, and the holding member 5 is placed thereon.", "Subsequently, while the holding member 5 is pressed to the sheet member 3, the bonding agent 4 is heated so that the seed crystal 2 and the holding member 5 are fixed.", "When the holding member 5 is pressed in this manner, it is possible to form the bonding parts 4ab in which the bonding agent 4b passes through the through holes 3a of the sheet member 3 in a region not overlapped with the holding member 5 in the plan view and goes around to the upper surface 3A of the sheet member 3.In the above description, it is described that the holding member 5 is smaller than the seed crystal 2, but the holding member 5 may be larger than the seed crystal 2 as illustrated in FIG.", "15.In this case, the sheet member 3 is smaller than the external forms of the seed crystal 2 and the holding member 5 in the plan view.", "Even in this case, since it is possible to alleviate the stress in the bonding agent 4 by the sheet member 3, it is possible to suppress the seed crystal 2 from being peeled off from the bonding agent 4.<Seed Crystal Growing Method> Next, the crystal growing method according to the present invention is described.", "The crystal growing method according to the present invention has a first preparation step, a second preparation step, and a growing step.", "(First Preparation Step and Second Preparation Step) In the first preparation step, the melting crucible 7 and the silicon solution 10 including carbon kept in the melting crucible 7 are prepared.", "Subsequently, in the second preparation step, the aforementioned seed crystal holder 1 is prepared.", "(Growing Step) Next, in the crystal growing device 6 as illustrated in FIG.", "1, the lower surface 2B of the seed crystal 2 is brought into contact with the silicon solution 10 including carbonization in the melting crucible 7.The contact of the seed crystal 2 with the solution 10 may be achieved by bringing a part of the lower surface 2B into contact with the solution 10.Further, the seed crystal 2 may be introduced in the solution 10, for example, to a degree in which the upper surface 2A of the seed crystal 2 is immersed in the solution 10.Thereafter, it is possible to grow the silicon carbide crystal from the solution 10 on the lower surface 2B of the seed crystal 2 by raising the holding member 5 upwardly (direction D2).", "The raising speed of the holding member 5 may be set, for example, according to the growing speed of the crystal grown on the lower surface 2B of the seed crystal 2.In the crystal growing method according to the present embodiment, since the crystal is grown on the lower surface 2B of the seed crystal 2 by using the seed crystal holder 1, even if the crystal grown on the lower surface 2B becomes large, the seed crystal 2 is caused not to be easily peeled off from the lower end surface 5A of the holding member 5.As a result, it is possible to improve the productivity of the crystal to be grown.", "(Modification of Crystal Growing Method) A step of immersing a part of the bonding agent 4 together with the seed crystal 2 in the solution 10 kept in the melting crucible 7 may be included between the second preparation step and the growing step.", "Since it is possible to include silicon as a component in the part of the bonding agent 4 by immersing the part of the bonding agent 4 together with the seed crystal 2 in the solution 10, it is possible to improve the thermal conductivity of the bonding agent 4.In this manner, it is possible to cause the seed crystal 2 not to be easily peeled off from the bonding agent 4.Therefore, even if the silicon carbide crystal is grown to be large on the lower surface 2B of the seed crystal 2, it is possible to cause the seed crystal 2 not to be easily peeled off from the bonding agent 4, and to cause the crystal to be grown to be large.", "In addition, the seed crystal 2, a part of the bonding agent 4, and the sheet member 3 may be immersed in the solution 10.In this case, since it is possible to cause the silicon as the component to be included in the sheet member 3, it is possible to improve the thermal conductivity of the bonding agent 4 and to improve the thermal conductivity of the sheet member 3.If the solution 10 has temperature distribution in the depth direction, when the bonding agent 4 is immersed in the solution 10, the seed crystal 2 may be immersed to the position in which the temperature is high.", "For example, the solution 10 is set to have the temperature distribution in the depth direction, for example, by performing setting so that the temperature increases as it goes deeper from a solution surface.", "Here, for example, with respect to the temperature of the solution surface, it is possible to set the temperature distribution to be in the range of equal to or lower than 50° C. In this case, it is possible to immerse the seed crystal 2 to come close to the vicinity of the base of the melting crucible 7.It is possible to dissolve miscellaneous crystals grown on the lower surface 2B of the seed crystal 2 by disposing the seed crystal 2 at a position of the high temperature.", "According to this, it is possible to further suppress the miscellaneous crystals from growing on the seed crystal 2.Further, when the seed crystal 2 is disposed at the position of the high temperature, the crystal grown on the lower surface 2B of the seed crystal 2 may be caused to be in contact with the base of the melting crucible 7.According to this, it is possible to surely dissolve the miscellaneous crystals and also to easily peel off the miscellaneous crystals physically." ] ]
Patent_15874212
[ [ "DUSTPROOF DEVICE FOR BALL SCREW", "A dustproof device is provided for use with a ball screw which includes a screw rod and a nut mounted around the screw rod.", "The dustproof device includes an annular body and an elastic valve plate.", "The annular body is disposed inside the nut and penetrated by the screw rod and has an outer annular surface provided with a debris exit.", "The debris exit has one end in communication with a spiral passage formed between the screw rod and the nut.", "The elastic valve plate, which is provided at the opposite end of the debris exit of the annular body, can be pushed open by a fluid and thus opens the debris exit, allowing the debris generated by the ball screw to be discharged through the debris exit along with the fluid, thereby contributing to extending the service life of the ball screw." ], [ "1.A dustproof device for a ball screw, wherein the ball screw comprises a screw rod and a nut mounted around the screw rod, the screw rod has a periphery provided with an external spiral groove, the nut has an inner periphery provided with an internal spiral groove, and the external spiral groove of the screw rod and the internal spiral groove of the nut correspond to each other and jointly form a spiral passage, the dustproof device comprising: an annular body disposed inside the nut and penetrated by the screw rod, the annular body having an inner annular surface provided with a dustproof lip abutting against the periphery of the screw rod, an outer annular surface provided with at least one debris exit, a first lateral surface, and a second lateral surface, the at least one debris exit being communicated with the first lateral surface to form a first opening and communicated with the second lateral surface to form a second opening, the at least one debris exit being communicated with the spiral passage via the first opening; and at least one elastic valve plate, which is connected to the annular body and blocks over the second opening.", "2.The dustproof device of claim 1, wherein the inner periphery of the nut has at least one valve plate groove in which the at least one elastic valve plate is located, and the at least one elastic valve plate is connected to the outer annular surface of the annular body.", "3.The dustproof device of claim 1, wherein the at least one elastic valve pate has an end connected to the inner annular surface of the annular body, and an opposite end extending in a direction away from the dustproof lip and abutting against the nut.", "4.A dustproof device for a ball screw, wherein the ball screw comprises a screw rod and a nut mounted around the screw rod, the screw rod has a periphery provided with an external spiral groove, the nut has an inner periphery provided with an internal spiral groove, and the external spiral groove of the screw rod and the internal spiral groove of the nut correspond to each other and jointly form a spiral passage, the dustproof device being provided at an end of the nut and penetrated by the screw rod, the dustproof device comprising: an annular body disposed inside the nut and penetrated by the screw rod, the annular body having an inner annular surface provided with a dustproof lip abutting against the periphery of the screw rod, an outer annular surface, a first lateral surface, and a second lateral surface provided with at least one debris exit communicated with the spiral passage via at least one pore that penetrates through the first lateral surface.", "5.The dustproof device of claim 4, wherein the pore has a circular cross-section.", "6.The dustproof device of claim 4, wherein the pore has a cross-shaped cross-section.", "7.The dustproof device of claim 4, wherein the at least debris exit is communicated with the spiral passage via at least three said pores radially arranged.", "8.The dustproof device of claim 4, wherein the annular body comprises a plate member provided with the debris exit, and a block member provided with the pore and coupled with the plate member inside the debris exit.", "9.The dustproof device of claim 8, wherein the plate member is made of a first material and the block member is made of a second material different from the first material." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The primary objective of the present invention is to provide a dustproof device applicable to a ball screw and featuring structural simplicity, a good sealing effect, and effectiveness in removing the debris between the nut and the screw rod of a ball screw so as to extend the service life of the ball screw.", "To achieve the above objective, a first dustproof device provided by the present invention includes an annular body and an elastic valve plate.", "The annular body is disposed inside a nut and penetrated by a screw rod.", "The annular body has an inner annular surface provided with a dustproof lip abutting against the periphery of the screw rod.", "The annular body further has an outer annular surface provided with at least one debris exit, a first lateral surface, and a second lateral surface.", "The debris exit is communicated with the first lateral surface to form a first opening and communicated with the second lateral surface to from a second opening.", "The debris exit is communicated with a spiral passage formed between the nut and the screw rod via the first opening.", "The elastic valve plate is connected to the annular body and blocks over the second opening.", "When subjected to the pressure of a fluid, the elastic valve plate opens the debris exit, allowing debris to flow out with the fluid through the debris exit.", "Once the pressure of the fluid is removed, the elastic valve plate closes the debris exit thanks to the elastic restoring force of the elastic valve plate itself.", "A second dustproof device provided by the present invention has an annular body disposed inside the nut and penetrated by the screw rod.", "The annular body has an inner annular surface provided with a dustproof lip abutting against the periphery of the screw rod, an outer annular surface, a first lateral surface, and a second lateral surface provided with a debris exit communicated with the spiral passage via a pore that penetrates through the first lateral surface.", "When a fluid reaches the dustproof device via the spiral passage, the pressure of the fluid pushes and expands the pore so that debris can flow out of the debris exit through the pore along with the fluid.", "As soon as the pressure of the fluid is removed, the pore restores its original diameter or shape." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation-in-part of U.S. patent application Ser.", "No.", "15/074,727, filed Mar.", "18, 2016.BACKGROUND OF THE INVENTION 1.Technical Field The present invention relates to ball screws and more particularly to a dustproof device for a ball screw.", "2.Description of Related Art When a ball screw is in operation, the rolling contact between the screw rod, the nut, and the balls causes abrasion and hence the generation of debris, or dust.", "If the debris remaining in the gap between the screw rod and the nut is not removed, the precision of transmission and the smoothness of operation of the ball screw will be compromised, and the service life of the ball screw will be shortened as a result.", "U.S. Pat.", "No.", "5,231,888 discloses sucking internally generated debris with a suction device, and yet the suction device adds to the complexity of the entire structure and to the installation cost.", "Japanese Patent No.", "4967809 uses a magnet to increase the closeness between the lip of a dustproof device and a screw rod, but debris tends to be attracted into and subsequently accumulate in the spiral groove of the screw rod.", "That is to say, the magnet, though contributing to an enhanced sealing effect, indirectly increases the operating resistance of the whole structure.", "SUMMARY OF THE INVENTION The primary objective of the present invention is to provide a dustproof device applicable to a ball screw and featuring structural simplicity, a good sealing effect, and effectiveness in removing the debris between the nut and the screw rod of a ball screw so as to extend the service life of the ball screw.", "To achieve the above objective, a first dustproof device provided by the present invention includes an annular body and an elastic valve plate.", "The annular body is disposed inside a nut and penetrated by a screw rod.", "The annular body has an inner annular surface provided with a dustproof lip abutting against the periphery of the screw rod.", "The annular body further has an outer annular surface provided with at least one debris exit, a first lateral surface, and a second lateral surface.", "The debris exit is communicated with the first lateral surface to form a first opening and communicated with the second lateral surface to from a second opening.", "The debris exit is communicated with a spiral passage formed between the nut and the screw rod via the first opening.", "The elastic valve plate is connected to the annular body and blocks over the second opening.", "When subjected to the pressure of a fluid, the elastic valve plate opens the debris exit, allowing debris to flow out with the fluid through the debris exit.", "Once the pressure of the fluid is removed, the elastic valve plate closes the debris exit thanks to the elastic restoring force of the elastic valve plate itself.", "A second dustproof device provided by the present invention has an annular body disposed inside the nut and penetrated by the screw rod.", "The annular body has an inner annular surface provided with a dustproof lip abutting against the periphery of the screw rod, an outer annular surface, a first lateral surface, and a second lateral surface provided with a debris exit communicated with the spiral passage via a pore that penetrates through the first lateral surface.", "When a fluid reaches the dustproof device via the spiral passage, the pressure of the fluid pushes and expands the pore so that debris can flow out of the debris exit through the pore along with the fluid.", "As soon as the pressure of the fluid is removed, the pore restores its original diameter or shape.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS FIG.", "1 is a perspective view of the first embodiment of the present invention; FIG.", "2 is a perspective view of the first embodiment of the present invention applied to a ball screw; FIG.", "3 is a sectional view of the first embodiment of the present invention applied to a ball screw, showing in particular the debris exit in the closed state; FIG.", "4 is a sectional view of the first embodiment of the present invention applied to a ball screw, showing in particular the debris exit in the open state; FIG.", "5 is a perspective view of the second embodiment of the present invention; FIG.", "6 is a perspective view of the second embodiment of the present invention applied to a nut; FIG.", "7 is a sectional view of the second embodiment of the present invention applied to a nut, showing in particular the debris exit in the open state; FIG.", "8 is a sectional view of the second embodiment of the present invention applied to a nut, showing in particular the debris exit in the closed state; FIG.", "9 is a perspective view of the third embodiment of the present invention; FIG.", "10 is a front view of the third embodiment of the present invention; FIG.", "11 is a sectional view of the third embodiment of the present invention applied to a ball screw; FIG.", "12 is a perspective view of the fourth embodiment of the present invention; FIG.", "13 is a front view of the fourth embodiment of the present invention; and FIG.", "14 is a sectional view of the fourth embodiment of the present invention applied to a ball screw.", "DETAILED DESCRIPTION OF THE INVENTION Referring to FIG.", "2 and FIG.", "3, the ball screw 10 in the drawings includes a screw rod 12, a nut 14 mounted around the screw rod 12, and a plurality of balls (not shown) provided between the screw rod 12 and the nut 14.The screw rod 12 is peripherally provided with an external spiral groove 122.The nut 14 has an inner periphery provided with an internal spiral groove 142.The external spiral groove 122 of the screw rod 12 and the internal spiral groove 142 of the nut 14 correspond to each other and jointly form a spiral passage 16 in and along which the balls can circulate.", "Referring to FIG.", "1, the dustproof device 18 of the present invention includes an annular body 20 and three elastic valve plates 30.The annular body 20 has an inner annular surface 201, an outer annular surface 202, a first lateral surface 203, a second lateral 204, two corresponding positioning flanges 21 on the outer annular surface 202, and two corresponding dustproof lips 22 on the inner annular surface 201.To assemble, the screw rod 12 is inserted through the annular body 20 until the positioning flanges 21 are engaged in the positioning groove 144 in the inner periphery of the nut 14.After assembly, the dustproof lips 22 of the annular body 20 abut against the periphery of the screw rod 12 to produce a sealing effect, preventing foreign matters from entering the gap between the screw rod 12 and the nut 14.In addition, three debris exits 23 are arranged along the outer annular surface 202 of the annular body 20.Each debris exit 23 is communicated with the first lateral surface 203 to form a first opening 205 and communicated with the second lateral surface 204 to form a second opening 206.Each debris exit 23 is communicated with the spiral passage 16 via the first opening 205.Each elastic valve plate 30 is connected with the annular body 20 and blocks over the second opening 206 of a respective debris exit 23.In this embodiment, the inner periphery of the nut 14 has three valve plate grooves 146 adjacent to the positioning groove 144.After assembly, the elastic valve plates 30, each having an end connected to the outer annular surface 202 of the annular body 20, are located in the valve plate grooves 146 of the nut 14 respectively and block over the debris exits 23 respectively.", "According to the above, a fluid (e.g., grease) injected into the nut 14 can carry debris along the spiral passage 16 to the debris exits 23, where the fluid applies an outward pushing force to the elastic valve plates 30.The pressure of the fluid pushes the elastic valve plates 30 to swing outwardly so as to open the second openings 206 of the debris exits 23, as shown in FIG.", "4, such that the debris is discharged together with the fluid through the second openings 206 of the debris exits 23.Once injection of the fluid is stopped, the pushing force applied by the fluid to the elastic valve plates 30 is removed, and the elastic valve plates 30 are driven by their inherent elastic restoring force to return to their initial positions so as to close the second openings 206 of the debris exits 23 respectively, as shown in FIG.", "3.Referring to FIG.", "5, a dustproof device 40 according to a second embodiment of the present invention comprises an annular body 42 and three elastic valve plates 44.The annular body 42 has an inner annular surface 421, an outer annular surface 422, a first lateral surface 423, and a second lateral 424.Further, the annular body 42 is provided at the outer annular surface 422 thereof with three debris exits 48, each of which is communicated with the first lateral surface 423 to form a first opening 425 and communicated with the second lateral surface 424 to form a second opening 426.Each debris exit 48 is in communication with the spiral passage 16 via the first opening 425.The second embodiment is different from the first embodiment in that each elastic valve plate 44 has one end connected to the inner annular surface 421 of the annular body 42 and an opposite end extending in a direction away from the dustproof lip 46 and abutting against an end surface of the nut 14.Thus, referring to FIGS.", "6-8, the elastic valve plates 44 open the debris exits 48 respectively when subjected to the pressure of a fluid and pushed away from the second openings 426, allowing debris to flow out of the debris exits 48 along with the fluid.", "When the pressure of the fluid is removed, the elastic valve plates 44 block over the second openings 426 to close the debris exits 48 respectively as a result of the elastic restoring force of the elastic valve plates 44.It is worth mentioning that the elastic valve plates are not essential to the dustproof device.", "Referring to FIG.", "9 and FIG.", "10 for a third embodiment of the present invention, the dustproof device 50 comprises an annular body 51 made of an elastic material such as rubber.", "The annular body 51 has an inner annular surface 511, an outer annular surface 512, a first lateral surface 513, and a second lateral 514 on which four debris exits 52 are equiangularly provided.", "Each debris exit 52 is in communication with the spiral passage 16 through four circular pores 54 penetrating through the first lateral surface 513.Referring to FIG.", "11, when a fluid flowing along the spiral passage 16 reaches the dustproof device 50, the pressure of the fluid can push and expand all the circular pores 54, allowing debris to flow out of the debris exits 52 with the fluid through the circular pores 54, whose diameters are now increased.", "Once the fluid pressure is removed, the walls of the circular pores 54 contract due to the elasticity of the material of the dustproof device 50 and thereby restore the circular pores 54 to their original diameters.", "As shown in FIG.", "10, the circular pores 54 that are communicated with one debris exit 52 of the dustproof device 50 are radially arranged.", "However, the present invention is not limited to this design.", "For example, referring to FIG.", "12 to FIG.", "14, each debris exit 62 of the dustproof device 60 is communicated with one cross-shaped pore 64.The cross-shaped pores 64 can be pushed and expanded by the pressure of a fluid to enable discharge of debris through the debris exits 62.When the pressure of the fluid is removed, the cross-shaped pores 64 resume their original shapes.", "It is worth mentioning that as shown in FIGS.", "9-11, the annular body 51 is composed of a plate member 515 formed with the four debris exits 52, and four block members 516 each provided with the circular pores 54 and coupled with the plate member 515 inside the debris exits 52 of the plate member 515.With this design, when the circular pores 54 of one or more block members 516 are damaged, the annular body 51 can be repaired by replacing the damaged block members 516 with new ones.", "Further, the plate member 515 can be made of a first material and the block members 516 can be made of a second material different from the first material so as to fulfill different use requirements.", "According to the above, the dustproof device of the present invention not only provides a good sealing effect, but also features a simpler structure and can discharge the debris in the gap between the screw rod and the nut of a ball screw more effectively than its prior art counterparts to extend the service life of the ball screw." ] ]
Patent_15874218
[ [ "SHEET PROCESSING APPARATUS AND IMAGE FORMING APPARATUS", "A sheet processing apparatus in which a sheet bundle including a plurality of sheets discharged onto an intermediate processing tray is received in a receiving portion of a stapler and bound with use of a staple, and a sheet bundle including a plurality of sheets discharged onto the intermediate processing tray is received in a receiving portion of a staple-less binding unit having a gap in the thickness direction of the sheets smaller than that of the receiving portion of the stapler and bound without using a staple, wherein when the stapler performs the binding process, the staple-less binding unit is arranged in a position shifted in a width direction orthogonal to a sheet discharge direction from a region on the intermediate processing tray, through which the sheets discharged by a sheet discharging portion pass." ], [ "1-18.", "(canceled) 19.A sheet processing apparatus, comprising: a support surface on which a sheet is supported; a first aligning member configured to contact a first edge on one side, in a sheet width direction, of the sheet supported on the support surface; a second aligning member configured to contact a second edge on the other side, in the sheet width direction, of the sheet supported on the support surface; an abutment portion configured to contact a third edge, parallel to the sheet width direction, of the sheet supported on the support surface; a first binding unit configured to bind first sheets, which are positioned by the abutment portion, the first aligning member, and the second aligning member, with a staple; and a second binding unit configured to bind second sheets, which are positioned by the abutment portion, the first aligning member, and the second aligning member, without using a staple, wherein the first binding unit is movable in the sheet width direction to a plurality of positions, the first binding unit binding the first sheets at a selected position among the plurality of positions, the plurality of positions including a position at which the first binding unit is located when the first binding unit binds a first part in a corner portion, on the one side in the sheet width direction and on a side of the third edge contacting the abutment portion, of the first sheets positioned by the abutment portion, the first aligning member, and the second aligning member, wherein the second binding unit is configured to bind a second part in a corner portion, on the one side in the sheet width direction and on the side of the third edge contacting the abutment portion, of the second sheets positioned by the abutment portion, the first aligning member, and the second aligning member, and wherein at least a part of the first binding unit and at least a part of the second binding unit overlap each other in a direction along the support surface and perpendicular to the sheet width direction as viewed along the sheet width direction at a time when the first binding unit binds the first part in the corner portion, on the one side in the sheet width direction and on the side of the third edge contacting the abutment portion, of the first sheets positioned by the abutment portion, the first aligning member, and the second aligning member.", "20.A sheet processing apparatus, comprising: a support surface on which a sheet is supported; a first aligning member configured to contact a first edge on one side, in a sheet width direction, of the sheet supported on the support surface; a second aligning member configured to contact a second edge on the other side, in the sheet width direction, of the sheet supported on the support surface; an abutment portion configured to contact a third edge, parallel to the sheet width direction, of the sheet supported on the support surface; a first binding unit configured to bind first sheets, in a state positioned by the abutment portion, the first aligning member, and the second aligning member, with a staple; and a second binding unit configured to bind second sheets, in the state positioned by the abutment portion, the first aligning member, and the second aligning member, without using a staple, wherein the first binding unit is movable in the sheet width direction to a plurality of positions, the first binding unit binding the first sheets at a selected position among the plurality of positions, the plurality of positions including a position at which the first binding unit is located when the first binding unit binds a first part in a corner portion, on the one side in the sheet width direction and on a side of the third edge contacting the abutment portion, of the first sheets positioned by the abutment portion, the first aligning member, and the second aligning member, wherein the second binding unit is configured to bind a second part in a corner portion, on the one side in the sheet width direction and on the side of the third edge contacting the abutment portion, of the second sheets positioned by the abutment portion, the first aligning member, and the second aligning member, and wherein a home position of the first binding unit is closer to the other side in the sheet width direction than the second binding unit is.", "21.A sheet processing apparatus according to claim 19, wherein the first edge on the one side, in the sheet width direction, of the sheet is positioned closer to the other side than the second binding unit is, at the time when the first binding unit binds the first part in the corner portion, on the one side in the sheet width direction and on the side of the third edge contacting the abutment portion, of the first sheets positioned by the abutment portion, the first aligning member, and the second aligning member.", "22.A sheet processing apparatus according to claim 19, wherein at least a part of the first binding unit and at least a part of the second binding unit overlap each other in the direction along the support surface and perpendicular to the sheet width direction as viewed along the sheet width direction at a time when the second binding unit binds the second part in the corner portion, on the one side in the sheet width direction and on the side of the third edge contacting the abutment portion, of the second sheets positioned by the abutment portion, the first aligning member, and the second aligning member.", "23.A sheet processing apparatus according to claim 19, wherein the second part to be bound by the second binding unit in the corner portion, on the one side in the sheet width direction and on the side of the third edge contacting the abutment portion, of the second sheets positioned by the abutment portion, the first aligning member, and the second aligning member is, in the sheet width direction, closer to the one side than a position of the second sheets contacting the abutment portion is and is, in a direction along the first edge, closer to the side of the third edge than a position of the second sheets contacting the first aligning member is.", "24.A sheet processing apparatus according to claim 19, wherein the second binding unit seizes the second sheets with a pair of members having concave and convex portions and pressurizes the second sheets to bind the second sheets.", "25.A sheet processing apparatus according to claim 19, wherein the second binding unit forms a half-blanking shape in the second part of the second sheets to bind the second sheets.", "26.A sheet processing apparatus according to claim 19, wherein a home position of the first binding unit is closer to the other side in the sheet width direction than a position of the first binding unit, at the time when the first binding unit binds the first part in the corner portion, on the one side in the sheet width direction and on the side of the third edge contacting the abutment portion, of the first sheets positioned by the abutment portion, the first aligning member, and the second aligning member, is.", "27.A sheet processing apparatus according to claim 19, wherein a home position of the first binding unit is closer to the other side in the sheet width direction than the second edge on the other side of the sheet supported on the support surface is.", "28.A sheet processing apparatus according to claim 19, further comprising: a conveyance path through which a sheet is conveyed; and a discharge portion configured to discharge the sheet passing through the conveyance path to the support surface.", "29.A sheet processing apparatus according to claim 28, further comprising a conveyance unit configured to contact a topmost sheet of a sheet bundle discharged by the discharge portion and supported on the support surface to convey the topmost sheet toward the abutment portion with the third edge being a downstream edge in a conveyance direction.", "30.A sheet processing apparatus according to claim 19, further comprising a stacking portion on which a sheet bundle after binding is stacked, wherein a sheet bundle bound by the first binding unit does not pass through the second binding unit while being moved so as to be stacked on the stacking portion.", "31.A sheet processing apparatus according to claim 19, further comprising a controller configured to control an operation of the first aligning member, an operation of the second aligning member, an operation of the first binding unit, and an operation of the second binding unit.", "32.An image forming apparatus comprising: an image forming portion configured to form an image on a sheet; a support surface on which the sheet, on which the image is formed by the image forming portion, is supported; a first aligning member configured to contact a first edge on one side, in a sheet width direction, of the sheet supported on the support surface; a second aligning member configured to contact a second edge on the other side, in the sheet width direction, of the sheet supported on the support surface; an abutment portion configured to contact a third edge, parallel to the sheet width direction, of the sheet supported on the support surface; a first binding unit configured to bind first sheets, which are positioned by the abutment portion, the first aligning member, and the second aligning member, with a staple; and a second binding unit configured to bind second sheets, which are positioned by the abutment portion, the first aligning member, and the second aligning member, without using a staple, wherein the first binding unit is movable in the sheet width direction to a plurality of positions, the first binding unit binding the first sheets at a selected position among the plurality of positions, the plurality of positions including a position at which the first binding unit is located when the first binding unit binds a first part in a corner portion, on the one side in the sheet width direction and on a side of the third edge contacting the abutment portion, of the first sheets positioned by the abutment portion, the first aligning member, and the second aligning member, wherein the second binding unit is configured to bind a second part in a corner portion, on the one side in the sheet width direction and on the side of the third edge contacting the abutment portion, of the second sheets positioned by the abutment portion, the first aligning member, and the second aligning member, and wherein at least a part of the first binding unit and at least a part of the second binding unit overlap each other in a direction along the support surface and perpendicular to the sheet width direction as viewed along the sheet width direction at a time when the first binding unit binds the first part in the corner portion, on the one side in the sheet width direction and on the side of the third edge contacting the abutment portion, of the first sheets positioned by the abutment portion, the first aligning member, and the second aligning member." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Field of the Invention The present invention relates to a sheet processing apparatus and an image forming apparatus, and more particularly, to a sheet processing apparatus and an image forming apparatus which are configured to bind sheets with use of a binding unit of different types.", "Description of the Related Art Hitherto, in image forming apparatus such as copying machines, laser beam printers, fax machines and multifunctional peripherals have included a sheet processing apparatus configured to bind sheets.", "In such a sheet processing apparatus, a sheet bundle, including a plurality of sheets, is bound using a metal staple.", "Such a stapling process can reliably bind a plurality of output sheets at a position specified by a user, and hence this process is adopted in many sheet processing apparatus.", "Further, in conventional sheet processing apparatus, there has been proposed an apparatus including, in addition to the binding unit using a staple, a binding unit configured to simply bind the sheets without using a staple, on the presumption that “unbinding” of the sheet bundle is to be performed after the binding (see Japanese Patent Application Laid-Open No.", "2000-318918).", "This apparatus includes, in addition to the staple binding unit configured to fasten a maximum of 50 sheets by a staple, a binding unit, as an example of staple-less binding unit, configured to perform simple binding of up to about 10 sheets by forming a half-blanking shaped fastening portion in a sheet bundle.", "When binding is to be performed in such a sheet processing apparatus, a selective moving mechanism selectively moves each of the binding unit arranged to be movable forward and backward to a binding position of the sheet bundle.", "Such a conventional sheet processing apparatus includes the selective moving mechanism for selectively moving each binding unit to the binding position, and hence the configuration of the apparatus becomes complicated.", "In order to prevent this, the following configurations may be considered.", "For example, at least the staple-less binding unit is fixed to eliminate the selective moving mechanism.", "By the way, when the maximum number of bindable sheets differs between the respective binding units as described above, generally, the height (width in an up-down direction) of a sheet receiving portion (hereinafter referred to as “opening”) opened in the thickness direction of the sheet bundle also differs depending on the maximum number of bindable sheets.", "Therefore, depending on the fixing positions at which the respective binding units are fixed and depending on the thickness of the sheet bundle when the binding is performed with, for example, the staple binding unit having a larger opening height (a larger maximum number of bindable sheets), the sheet bundle interferes with the staple-less binding unit having a smaller opening height (a smaller maximum number of bindable sheets)." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention has been made in view of such an actual situation, and has an object to provide a sheet processing apparatus and an image forming apparatus which are capable of performing a binding process without requiring the upsizing of the apparatus and the lowering of the binding process efficiency, even when binding units are used that differ in receiving portion height.", "According to one embodiment of the present invention, there is provided a sheet processing apparatus, including: a sheet stacking portion arranged to receive sheets; a sheet discharging portion configured to discharge the sheets onto the sheet stacking portion; a first binding unit including a first receiving portion having a gap in a thickness direction of the sheets and being configured to receive the sheets discharged onto the sheet stacking portion by the sheet discharging portion, the first binding unit being arranged to perform a binding process, using a staple, on a sheet bundle including a plurality of the sheets received in the gap of the first receiving portion; a second binding unit including a second receiving portion having a gap in a thickness direction of the sheets, the gap being smaller than the gap of the first receiving portion, the second binding unit being arranged to perform a binding process, without using a staple, on a sheet bundle including a plurality of the sheets received in the gap of the second receiving portion; and a moving unit configured to move a sheet, discharged onto the sheet stacking portion, wherein, in the case that a sheet is moved into the first receiving portion, the second binding unit is arranged in a position in which the sheets moved into the first receiving portion by the moving unit do not enter the second receiving portion.", "As in the one embodiment of the present invention, by arranging the second binding unit in the position at which the sheets, moved into the first receiving portion of the first binding unit, do not enter the second receiving portion of the second binding unit, even when the binding unit which differ in height of the receiving portion are used, the binding process may be performed without upsizing the apparatus and lowering the binding process efficiency.", "Further features of the present invention will become apparent from the following description of exemplary embodiments with reference to the attached drawings." ], [ "BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to a sheet processing apparatus and an image forming apparatus, and more particularly, to a sheet processing apparatus and an image forming apparatus which are configured to bind sheets with use of a binding unit of different types.", "Description of the Related Art Hitherto, in image forming apparatus such as copying machines, laser beam printers, fax machines and multifunctional peripherals have included a sheet processing apparatus configured to bind sheets.", "In such a sheet processing apparatus, a sheet bundle, including a plurality of sheets, is bound using a metal staple.", "Such a stapling process can reliably bind a plurality of output sheets at a position specified by a user, and hence this process is adopted in many sheet processing apparatus.", "Further, in conventional sheet processing apparatus, there has been proposed an apparatus including, in addition to the binding unit using a staple, a binding unit configured to simply bind the sheets without using a staple, on the presumption that “unbinding” of the sheet bundle is to be performed after the binding (see Japanese Patent Application Laid-Open No.", "2000-318918).", "This apparatus includes, in addition to the staple binding unit configured to fasten a maximum of 50 sheets by a staple, a binding unit, as an example of staple-less binding unit, configured to perform simple binding of up to about 10 sheets by forming a half-blanking shaped fastening portion in a sheet bundle.", "When binding is to be performed in such a sheet processing apparatus, a selective moving mechanism selectively moves each of the binding unit arranged to be movable forward and backward to a binding position of the sheet bundle.", "Such a conventional sheet processing apparatus includes the selective moving mechanism for selectively moving each binding unit to the binding position, and hence the configuration of the apparatus becomes complicated.", "In order to prevent this, the following configurations may be considered.", "For example, at least the staple-less binding unit is fixed to eliminate the selective moving mechanism.", "By the way, when the maximum number of bindable sheets differs between the respective binding units as described above, generally, the height (width in an up-down direction) of a sheet receiving portion (hereinafter referred to as “opening”) opened in the thickness direction of the sheet bundle also differs depending on the maximum number of bindable sheets.", "Therefore, depending on the fixing positions at which the respective binding units are fixed and depending on the thickness of the sheet bundle when the binding is performed with, for example, the staple binding unit having a larger opening height (a larger maximum number of bindable sheets), the sheet bundle interferes with the staple-less binding unit having a smaller opening height (a smaller maximum number of bindable sheets).", "SUMMARY OF THE INVENTION The present invention has been made in view of such an actual situation, and has an object to provide a sheet processing apparatus and an image forming apparatus which are capable of performing a binding process without requiring the upsizing of the apparatus and the lowering of the binding process efficiency, even when binding units are used that differ in receiving portion height.", "According to one embodiment of the present invention, there is provided a sheet processing apparatus, including: a sheet stacking portion arranged to receive sheets; a sheet discharging portion configured to discharge the sheets onto the sheet stacking portion; a first binding unit including a first receiving portion having a gap in a thickness direction of the sheets and being configured to receive the sheets discharged onto the sheet stacking portion by the sheet discharging portion, the first binding unit being arranged to perform a binding process, using a staple, on a sheet bundle including a plurality of the sheets received in the gap of the first receiving portion; a second binding unit including a second receiving portion having a gap in a thickness direction of the sheets, the gap being smaller than the gap of the first receiving portion, the second binding unit being arranged to perform a binding process, without using a staple, on a sheet bundle including a plurality of the sheets received in the gap of the second receiving portion; and a moving unit configured to move a sheet, discharged onto the sheet stacking portion, wherein, in the case that a sheet is moved into the first receiving portion, the second binding unit is arranged in a position in which the sheets moved into the first receiving portion by the moving unit do not enter the second receiving portion.", "As in the one embodiment of the present invention, by arranging the second binding unit in the position at which the sheets, moved into the first receiving portion of the first binding unit, do not enter the second receiving portion of the second binding unit, even when the binding unit which differ in height of the receiving portion are used, the binding process may be performed without upsizing the apparatus and lowering the binding process efficiency.", "Further features of the present invention will become apparent from the following description of exemplary embodiments with reference to the attached drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a view illustrating a configuration of an image forming apparatus including a sheet processing apparatus according to a first embodiment of the present invention.", "FIGS.", "2A and 2B are explanatory views illustrating a finisher serving as the sheet processing apparatus.", "FIG.", "3 is an explanatory view illustrating a configuration of a binding portion provided in the finisher.", "FIG.", "4 is an explanatory view illustrating a configuration of a stapler provided in the binding portion.", "FIGS.", "5A and 5B are explanatory views illustrating a configuration of a staple-less binding unit provided in the binding portion.", "FIGS.", "6A and 6B are explanatory views illustrating an operation of the staple-less binding unit provided in the binding portion.", "FIG.", "7 is an explanatory view illustrating the configuration of the staple-less binding unit provided in the binding portion.", "FIG.", "8 is a control block diagram of the image forming apparatus.", "FIG.", "9 is a control block diagram of the finisher.", "FIG.", "10 is a sectional view illustrating a state of sheets subjected to staple-less binding by the staple-less binding unit.", "FIGS.", "11A, 11B, and 11C are explanatory views illustrating an operation of a sheet binding process of the finisher.", "FIGS.", "12A, 12B, and 12C are explanatory views illustrating a binding process performed by the stapler provided in the finisher.", "FIG.", "13 is an explanatory view illustrating a binding process performed by the staple-less binding unit.", "FIG.", "14 is an explanatory view illustrating a configuration of a binding portion provided in a finisher serving as a sheet processing apparatus according to a second embodiment of the present invention.", "FIGS.", "15A and 15B are explanatory views illustrating an operation of a stapler provided in the binding portion before staple-less binding is performed.", "FIG.", "16 is a flow chart illustrating a binding operation of the finisher.", "FIGS.", "17A and 17B are explanatory views illustrating a binding operation of a finisher serving as a sheet processing apparatus according to a third embodiment of the present invention.", "FIG.", "18 is an explanatory view illustrating the binding operation of the finisher.", "FIG.", "19 is a flow chart illustrating the binding operation of the finisher.", "FIG.", "20 is a view illustrating a half-blanking shape formed by the staple-less binding unit.", "DESCRIPTION OF THE EMBODIMENTS Now, embodiments of the present invention will be described in detail with reference to the drawings.", "Each of the embodiments of the present invention described below can be implemented solely or as a combination of a plurality of the embodiments or features thereof where necessary or where the combination of elements or features from individual embodiments in a single embodiment is beneficial.", "FIG.", "1 is a view illustrating a configuration of an image forming apparatus including a sheet processing apparatus according to a first embodiment of the present invention.", "In FIG.", "1, an image forming apparatus 900 includes an image forming apparatus main body (hereinafter referred to as “apparatus main body”) 900A and an image forming portion 900B configured to form an image on a sheet.", "On the upper portion of the apparatus main body 900A, an image reading apparatus 950 including a document feeder 950A is provided, and a finisher 100 serving as a sheet processing apparatus is arranged between the upper side of the apparatus main body 900A and the image reading apparatus 950.In this case, the image forming portion 900B includes photosensitive drums “a” to “d” configured to form toner images of four colors of yellow, magenta, cyan, and black, and an exposure device 906 configured to form electrostatic latent images on the photosensitive drums by emitting laser beams based on image information.", "Note that, the photosensitive drums “a” to “d” are respectively driven by motors (not shown), and are respectively provided with primary charging devices (not shown), developing devices (not shown), and transfer charging devices 902a to 902d arranged so as to surround the respective photosensitive drums.", "Those members are incorporated into process cartridges 901a to 901d as units.", "An intermediate transfer belt 902 is driven to rotate in a direction indicated by an arrow.", "By the transfer charging devices 902a applying transfer biases to 902d to the intermediate transfer belt 902, the toner images of respective colors, which are formed on the photosensitive drums, are sequentially transferred on the intermediate transfer belt 902 in a multilayered manner.", "With this, a full color image is formed on the intermediate transfer belt.", "A secondary transfer portion 903 transfers the full color image sequentially formed on the intermediate transfer belt 902 onto a sheet P. The secondary transfer portion 903 includes a secondary transfer opposing roller 903b configured to support the intermediate transfer belt 902, and a secondary transfer roller 903a which abuts against the secondary transfer opposing roller 903b across the intermediate transfer belt 902.Further, there are provided registration rollers 909, a sheet feeding cassette 904, and a pick-up roller 908 configure to feed the sheet P received in the sheet feeding cassette 904.A CPU circuit portion 200 serving as a control portion controls the apparatus main body 900A and the finisher 100.Next, an image forming operation of the image forming apparatus 900 configured as described above will be described.", "When the image forming operation is started, first, the exposure device 906 emits laser light based on the image information from a personal computer (not shown) or the like, to thereby sequentially expose the surfaces of the photosensitive drums “a” to “d”, which have been uniformly charged at a predetermined polarity and potential.", "Thus, electrostatic latent images are formed on the photosensitive drums “a” to “d”.", "After that, the electrostatic latent images are developed with toner to be visualized.", "For example, first, the photosensitive drum “a” is irradiated with laser light via a polygon mirror and the like of the exposure device 906 based on the image signal for yellow component color of the document, to thereby form an electrostatic latent image for yellow on the photosensitive drum “a”.", "Then, the electrostatic latent image for yellow is developed with yellow toner supplied from the developing device to be visualized as a yellow toner image.", "After that, along with the rotation of the photosensitive drum “a”, the toner image arrives at a primary transfer portion at which the photosensitive drum “a” and the intermediate transfer belt 902 abut against each other.", "In this case, when the toner image arrives at the primary transfer portion as described above, due to a primary transfer bias applied to the transfer charging device 902a, the yellow toner image on the photosensitive drum “a” is transferred onto the intermediate transfer belt 902 (primary transfer).", "Next, when a part of the intermediate transfer belt 902 bearing the yellow toner image moves, a magenta toner image which has been formed by this time on the photosensitive drum “b” by a method similar to the above is transferred onto the intermediate transfer belt 902 from above the yellow toner image.", "Similarly, as the intermediate transfer belt 902 moves, a cyan toner image and a black toner image are transferred onto the yellow toner image and the magenta toner image in an overlapped manner at the respective primary transfer portions.", "With this, a full color toner image is formed on the intermediate transfer belt 902.Further, in parallel with the toner image forming operation, the sheets P contained in the sheet feeding cassette 904 are sent one by one by the pick-up roller 908.Then, the sheet P arrives at the registration rollers 909, and after the timing is adjusted by the registration rollers 909, the sheet P is conveyed to the secondary transfer portion 903.After that, at the secondary transfer portion 903, due to a secondary transfer bias to be applied to the secondary transfer roller 903a serving as a transfer portion, the toner images of four colors, which are formed on the intermediate transfer belt 902, are collectively transferred onto the sheet P (secondary transfer).", "Next, the sheet P having the toner images transferred thereon is guided by a conveyance guide 920 from the secondary transfer portion 903 to be conveyed to a fixing portion 905.When the sheet P passes through the fixing portion 905, the sheet P receives heat and pressure so that the toner image is fixed to the sheet P. After that, the sheet P having the image fixed thereto as described above passes through a discharge path 921 provided on the downstream of the fixing portion 905.Then, the sheet P is discharged by a discharge roller pair 918, and conveyed to the finisher 100.In this case, the finisher 100 performs a process of sequentially taking in the sheets discharged from the apparatus main body 900A and aligning the plurality of sheets thus taken-in to bundle the plurality of sheets into one sheet bundle.", "In addition, the finisher 100 performs a binding process of binding an end of the sheet bundle on upstream in the sheet discharge direction (hereinafter referred to as “trailing end”).", "As illustrated in FIGS.", "2A and 2B, the finisher 100 includes a processing portion 139 configured to perform the binding process as necessary, and discharging and stacking the sheets on a stacking tray 114.Note that, the processing portion 139 includes an intermediate processing tray 107 serving as a sheet stacking portion on which the sheets to be subjected to the binding process are stacked, and a binding portion 100A configured to bind the sheets stacked on the intermediate processing tray 107.Further, the intermediate processing tray 107 is provided with a near side aligning plate 109a and a far side aligning plate 109b which are illustrated in FIG.", "3 referred to later, configured to restrict (align) the positions of both side edges in a width direction (lateral direction) of a sheet which has been conveyed to the intermediate processing tray 107 in a direction orthogonal to the lateral direction of the apparatus main body 900A.", "Note that, the near side aligning plate 109a and the far side aligning plate 109b serving as a side edge aligning portion configured to align positions of side edges in the width direction of the sheets stacked on the intermediate processing tray 107 move in the width direction by being driven by an aligning motor M253 illustrated in FIG.", "9 referred to later.", "Further, the near side aligning plate 109a and the far side aligning plate 109b are generally moved by the aligning motor M253 driven based on a detection signal of an aligning HP sensor (not shown) to a receiving position at which the sheets are received.", "Then, when the positions of both the side edges of the sheets stacked on the intermediate processing tray 107 are to be restricted, the aligning motor M253 is driven to move the near side aligning plate 109a and the far side aligning plate 109b in the width direction so that the near side aligning plate 109a and the far side aligning plate 109b abut against both the side edges of the sheets stacked on the intermediate processing tray.", "Further, as illustrated in FIGS.", "2A and 2B, a pull-in paddle 106 is arranged above the intermediate processing tray 107 on downstream in the sheet conveyance direction.", "In this case, before the sheet enters the processing portion 139, a paddle raising and lowering motor M252 is driven based on detection information from a paddle HP sensor S243 illustrated in FIG.", "9 referred to later so that the pull-in paddle 106 is set to a wait state at an upper position so as not to interfere with the sheet to be discharged.", "Further, after the sheets are discharged onto the intermediate processing tray 107, the pull-in paddle 106 is moved downward due to the reverse drive of the paddle raising and lowering motor M252, and is rotated in a counterclockwise direction at an appropriate timing by a paddle motor (not shown).", "With this rotation, the pull-in paddle 106 pulls in the sheets so that trailing edges of the sheets are hit against a trailing edge stopper 108.In this embodiment, the pull-in paddle 106, the trailing edge stopper 108, the near side aligning plate 109a, and the far side aligning plate 109b constitute an aligning portion 130 configured to align the sheets stacked on the intermediate processing tray 107.Note that, for example, when the intermediate processing tray 107 is steep, the sheets can abut against the trailing edge stopper 108 without using the pull-in paddle 106 or a knurled belt 117 to be described later.", "Note that, in FIGS.", "2A and 2B, a trailing edge assist 112 is illustrated.", "The trailing edge assist 112 is moved from such a position that the trailing edge assist 112 does not inhibit the movement of a stapler to be described later to a receiving position configured to receive the sheets by an assist motor M254 which is driven based on a detection signal of an assist HP sensor S244 illustrated in FIG.", "9 referred to later.", "Then, after the sheet bundle is subjected to the binding process as described later, the trailing edge assist 112 discharges the sheet bundle onto the stacking tray 114.Further, the finisher 100 includes an inlet roller pair 101 configured to introduce the sheets inside the apparatus, and delivery rollers 103.The sheets discharged from the apparatus main body 900A are passed to the inlet roller pair 101.Note that, at this time, the passing timing of the sheet is simultaneously detected by an inlet sensor S240.Then, the sheets passed to the inlet roller pair 101 are sequentially discharged onto the intermediate processing tray 107 by the delivery rollers 103 serving as a sheet discharging portion.", "After that, by a moving unit such as the pull-in paddle 106 and the knurled belt 117, the sheets are hit against the trailing edge stopper 108.With this, the sheets are aligned in the sheet conveyance direction, and the sheet bundle that has undergone the aligning process is formed.", "Note that, a trailing end dropper 105 is pushed upward by the sheet passing through the delivery rollers 103 as illustrated in FIG.", "2A.", "Then, after the sheet P passes through the delivery rollers 103, the trailing end dropper 105 drops by its own weight as illustrated in FIG.", "2B to push down the trailing end of the sheet P from above.", "Further, a static charge eliminator 104 and a sheet bundle presser 115 are provided.", "The sheet bundle presser 115 is rotated by a sheet bundle presser motor M255 illustrated in FIG.", "9 referred to later, to thereby press the sheet bundle stacked on the stacking tray 114.Further, a tray lower limit sensor S242, a sheet bundle presser home position (HP) sensor S245, and a tray home position (HP) sensor S241 are provided.", "When the sheet bundle shields the tray HP sensor S241 from light, a tray raising and lowering motor M251 illustrated in FIG.", "9 lowers the stacking tray 114 until the tray HP sensor S241 becomes a transmissive state to determine the sheet surface position.", "Further, as illustrated in FIG.", "3, the binding portion 100A includes a stapler 110 serving as a staple binding portion, and a staple-less binding unit 102 serving as a staple-less binding portion.", "Note that, FIG.", "3 illustrates a state in which the stapler 110 is located at a home position (HP).", "In this case, the stapler 110 serving as a first binding unit configured to subject the sheets to the binding process with a staple is mounted on a staple support 150.Note that, the staple support 150 is moved by a STP moving motor M258 illustrated in FIG.", "9 referred to later under a state in which guides 1112 and 1113 of the staple support 150 are guided by grooves of a moving guide 1111 provided in a staple moving base 111.With this, the stapler 110 moves on the staple moving base while changing its orientation with respect to the sheet.", "Note that, in FIG.", "3, a staple (STP) HP sensor S247 configured to detect the home position (HP) of the movable stapler 110 is illustrated.", "In this embodiment, the HP of the stapler 110 is set on the near side with respect to the intermediate processing tray 107 in the lateral direction of the apparatus main body 900A (hereinafter referred to as “near side of the apparatus main body”).", "By setting the home position of the stapler 110 on the near side of the apparatus main body 900A, the U-shaped staple can be easily replaced.", "In this case, as illustrated in FIG.", "4, the stapler 110 serving as the staple binding portion includes a driving portion 1101 configured to drive the staple, an anvil portion 1102 configured to bend the driven staple, and a jaw portion 1103 which connects the driving portion 1101 and the anvil portion 1102 to each other.", "The stapler 110 drives the staple from the driving portion 1101 by a STP motor M256 illustrated in FIG.", "9 referred to later in a direction from the back surface to the front surface of the sheet bundle on the intermediate processing tray 107.Then, the anvil portion 1102 bends the leading end part of the driven staple by 90° to perform staple binding.", "Further, when the sheet bundle to be subjected to staple binding is received, in other words, when a driving operation is not performed, the driving portion 1101 and the anvil portion 1102 wait while maintaining a gap L1 therebetween so as to enable entrance of sheets between the driving portion 1101 and the anvil portion 1102.As an example of the size of the gap L1, when the number of sheets to be subjected to binding is 50, the gap L1 is set to 20 mm to enable the reception of the sheets.", "This is set considering air layers or the like formed between the sheets when the sheets are stacked, while the thickness of a sheet bundle of 50 sheets each being 64 g/m2 is about 5 mm.", "In other words, in this embodiment, the stapler 110 has an opening 140 serving as a first receiving portion whose width (gap) in a thickness direction for receiving the sheet bundle discharged onto the intermediate processing tray 107 is 20 mm.", "As illustrated in FIG.", "3, the staple-less binding unit 102 serving as a second binding unit configured to subject the sheets to the binding process without using a staple is provided on the far side with respect to the intermediate processing tray 107 in the lateral direction of the apparatus main body 900A (hereinafter referred to as “far side of the apparatus main body”).", "Further, as illustrated in FIG.", "5A, the staple-less binding unit 102 includes a staple-less binding motor M257, a gear 1021 which is rotated by the staple-less binding motor M257, and stepped gears 1022 to 1024 which are rotated by the gear 1021.The staple-less binding unit 102 further includes a gear 1025 which is rotated by the stepped gears 1022 to 1024.The staple-less binding unit 102 further includes a lower arm 10212 fixed to a frame 10213, and an upper arm 1029 provided to the lower arm 10212 so as to be swingable about a shaft 10211.The upper arm 1029 is biased toward the lower arm by a biasing member (not shown).", "In this case, the gear 1025 is mounted to a rotational shaft 1026.As illustrated in FIG.", "5B, a cam 1027 is mounted to the rotational shaft 1026, and the cam 1027 is provided between the upper arm 1029 and the lower arm 10212.With this, when the staple-less binding motor M257 is rotated, the rotation of the staple-less binding motor M257 is transmitted via the gear 1021, the stepped gears 1022 to 1024, and the gear 1025 to the rotational shaft 1026 so that the cam 1027 is rotated.", "When the cam 1027 is rotated as described above, a cam-side end portion of the upper arm 1029 which has been brought into pressure-contact with the cam 1027 by the biasing member (not shown) via a roller 1028 by then as illustrated in FIG.", "6A is raised as illustrates in FIG.", "6B.", "In this case, an upper tooth 10210 is mounted to a lower end of an end portion of the upper arm 1029 on a side opposite to the cam 1027, and a lower tooth 10214 is mounted to an upper end of an end portion of the lower arm 10212 on the side opposite to the cam 1027.Note that, FIG.", "7 is a view seen from the direction indicated by an arrow of FIG.", "6B.", "Each of the lower tooth 10214 and the upper tooth 10210 has a concave and convex portion.", "With this, when the cam-side end portion of the upper arm 1029 is raised, the end portion of the upper arm 1029 on the side opposite to the cam 1027 is lowered.", "Accordingly, the upper tooth 10210 is lowered to mesh with the lower tooth 10214, to thereby pressurize the sheets.", "When the sheets are pressurized as described above, the sheets P are stretched so that the fibers on the surfaces are exposed.", "With further pressurization, the fibers of the sheets tangle with each other, and thus the sheets are fastened.", "In other words, when the sheets are subjected to the binding process, the upper arm 1029 is swung, and thus the upper tooth 10210 of the upper arm 1029 and the lower tooth 10214 of the lower arm 10212 mesh with each other to pressurize the sheets.", "In this manner, the sheets are fastened.", "FIG.", "8 is a control block diagram of the image forming apparatus 900.In FIG.", "8, the CPU circuit portion 200 is illustrated, which is arranged at a predetermined position of the apparatus main body 900A as illustrated in FIG.", "1.The CPU circuit portion 200 includes a CPU 201, a ROM 202 having a control program or the like stored thereon, and a RAM 203 used as a region for temporarily storing control data or as an operation region for calculation performed along control.", "Further, in FIG.", "8, an external interface 209 for the image forming apparatus 900 and an external PC (computer) 208 is illustrated.", "When the external interface 209 receives print data from the external PC 208, the external interface 209 develops the data to a bitmap image, and outputs the bitmap image as image data to an image signal control portion 206.Then, the image signal control portion 206 outputs the data to a printer control portion 207, and the printer control portion 207 outputs the data from the image signal control portion 206 to an exposure control portion (not shown).", "Note that, image data of a document read by an image sensor (not shown) provided in the image reading apparatus 950 is output from an image reader control portion 205 to the image signal control portion 206, and the image signal control portion 206 outputs the image data to the printer control portion 207.Further, an operating portion 210 includes a display portion configured to display the setting state and a plurality of keys configured to set various functions relating to image formation.", "The operating portion 210 outputs, to the CPU circuit portion 200, a key signal corresponding to the operation of each key performed by a user, and displays, on the display portion, corresponding information based on the signal from the CPU circuit portion 200.The CPU circuit portion 200 controls the image signal control portion 206 in accordance with the control program stored in the ROM 202 and the setting obtained through the operating portion 210, and controls the document feeder 950A (see FIG.", "1) via a document feeder (DF) control portion 204.Further, the CPU circuit portion 200 controls the image reading apparatus 950 (see FIG.", "1) via the image reader control portion 205, controls the image forming portion 900B (see FIG.", "1) via the printer control portion 207, and controls the finisher 100 via a finisher control portion 220.Note that, in this embodiment, the finisher control portion 220 is mounted to the finisher 100, and performs control to drive the finisher 100 by exchanging information with the CPU circuit portion 200.Alternatively, the finisher control portion 220 may be provided integrally with the CPU circuit portion 200 on the apparatus main body side, to thereby control the finisher 100 directly from the apparatus main body side.", "FIG.", "9 is a control block diagram of the finisher 100 according to this embodiment.", "The finisher control portion 220 includes a CPU (microcomputer) 221, a ROM 222, and a RAM 223.The finisher control portion 220 communicates with the CPU circuit portion 200 via a communication IC 224 to exchange data, and executes various programs stored in the ROM 222 based on the instruction from the CPU circuit portion 200 to control the drive of the finisher 100.Further, the finisher control portion 220 drives, via a driver 225, a conveyance motor M250, the tray raising and lowering motor M251, the paddle raising and lowering motor M252, the aligning motor M253, the assist motor M254, and the sheet bundle presser motor M255.Further, the finisher control portion 220 drives, via the driver 225, the STP motor M256, the staple-less binding motor M257, and the like.", "Further, the finisher control portion is connected to the inlet sensor S240, a sheet discharge sensor S246, the tray HP sensor S241, the tray lower limit sensor S242, the paddle HP sensor S243, and the assist HP sensor S244.Further, the finisher control portion 220 is connected to the sheet bundle presser HP sensor S245 and the STP HP sensor S247.The finisher control portion 220 drives the aligning motor M253, the STP moving motor M258, the staple-less binding motor M257, and the like based on the detection signals from the respective sensors.", "By the way, when the sheets are subjected to staple-less binding, the finisher control portion 220 configured to control such an operation of the staple-less binding unit 102 first detects the cam position by a sensor (not shown).", "Then, at the time of reception of the sheets before the staple-less binding, the finisher control portion 220 controls the rotation of the staple-less binding motor M257 so that the cam 1027 is located at a bottom dead center as illustrated in FIG.", "6A.", "Note that, when the cam 1027 is located at the bottom dead center, a gap L2 is generated between the upper tooth 10210 and the lower tooth 10214, to thereby allow entrance of a plurality of sheets to be subjected to staple-less binding.", "At this time, the gap L2 between the upper tooth 10210 and the lower tooth 10214 is provided to be slightly wider than the number of sheets to be fastened.", "As an example, when the number of sheets to be fastened is 5, the gap L2 between the upper tooth 10210 and the lower tooth 10214 is 3 mm, which allows the entrance of the sheets.", "This is set considering air layers or the like formed between the sheets when the sheets are stacked, while the thickness of a sheet bundle of 5 sheets each being 64 g/m2 is about 0.5 mm.", "In other words, in this embodiment, as illustrated in FIG.", "6A referred to later, the staple-less binding unit 102 has an opening 141 as a second receiving portion whose width (gap) in a thickness direction for receiving the sheet bundle discharged onto the intermediate processing tray 107 is 3 mm.", "Further, during the binding operation, the staple-less binding motor M257 is rotated, and the upper arm 1029 is swung by the cam 1027 clockwise about the shaft 10211.Then, when the cam 1027 is located at a top dead center as illustrated in FIG.", "6B, the upper tooth 10210 of the upper arm 1029 and the lower tooth 10214 of the lower arm 10212 mesh with each other.", "With this, the sheets are fastened.", "Note that, when the cam 1027 is further rotated after the cam 1027 is located at the top dead center, a flexure portion 1029a provided in the upper arm 1029 may warp so that the roller 1028 can climb over the top dead center of the cam 1027.Further, after that, when the cam 1027 is further rotated to arrive at the bottom dead center again, a sensor (not shown) detects the cam 1027, and thus the finisher control portion 220 stops the rotation of the staple-less binding motor M257.FIG.", "10 is a view illustrating a state of a sheet bundle of 5 sheets P which has undergone staple-less binding by the staple-less binding unit 102.The sheets are pressurized to have a concave and convex shape by the upper tooth 10210 and the lower tooth 10214.In this manner, the fibers of the sheets P tangle with each other to fasten the sheets P. Next, a sheet binding process operation of the finisher 100 according to the embodiment will be described.", "As illustrated in FIG.", "2A referred to above, the sheets P discharged from the image forming apparatus 900 are passed to the inlet roller pair 101 which is driven by the conveyance motor M250.At this time, the leading edge of the sheet P is detected by the inlet sensor S240 to simultaneously detect the passing timing of the sheet.", "Next, the sheet P passed to the inlet roller pair 101 is passed from the inlet roller pair 101 to the delivery rollers 103.The sheet P is conveyed while the leading edge of the sheet P raises the trailing end dropper 105, and simultaneously, the static charge is eliminated by the static charge eliminator 104.In this state, the sheet P is discharged onto the intermediate processing tray 107.The sheet P discharged onto the intermediate processing tray 107 by the delivery rollers 103 is pressed from above by the trailing end dropper 105 with its own weight.", "In this manner, the time for dropping the trailing end of the sheet P onto the intermediate processing tray 107 is reduced.", "Next, based on the signal of a trailing edge of the sheet P detected by the sheet discharge sensor S246, the finisher control portion 220 performs control in the intermediate processing tray 107.That is, as illustrated in FIG.", "2B referred to above, the paddle raising and lowering motor M252 lowers the pull-in paddle 106 toward the intermediate processing tray 107 so that the pull-in paddle 106 comes into contact with the sheet P. At this time, the pull-in paddle 106 is rotated in a counterclockwise direction by the conveyance motor M250, and hence the sheet P is conveyed toward the trailing edge stopper 108 in the right direction in FIG.", "2B by the pull-in paddle 106.After that, the trailing edge of the sheet P is passed to the knurled belt 117.Note that, when the trailing edge of the sheet P is passed to the knurled belt 117, the paddle raising and lowering motor M252 is driven in a raising direction.", "When the paddle HP sensor S243 detects that the paddle 106 has arrived at the HP, the finisher control portion 220 stops the driving of the paddle raising and lowering motor M252.The knurled belt 117, served as a moving unit, conveys the sheet P which has been conveyed by the pull-in paddle 106 to the trailing edge stopper 108, and then rotates while slipping with respect to the sheet P, to thereby constantly bias the sheet P against the trailing edge stopper 108.With this slipping rotation, the sheet P can be hit against the trailing edge stopper 108, and thus the skew of the sheet P can be corrected.", "Next, after the sheet P abuts against the trailing edge stopper 108 as described above, the finisher control portion 220 drives the aligning motor M253 to move the aligning plates 109 in the width direction orthogonal to the sheet discharge direction, to thereby align the sheet P in the width direction.", "This series of operations is repeated with respect to a predetermined number of sheets to be subjected to the binding process.", "In this manner, as illustrated in FIG.", "11A, a sheet bundle PA aligned on the intermediate processing tray 107 is formed in a state of the sheets entering the opening 140 of the stapler 110.Next, after such an aligning operation is performed, when a binding mode is selected, the binding portion performs the binding process.", "After that, as illustrated in FIG.", "11B, the trailing edge assist 112 and a discharge claw 113 which are driven by the same assist motor M254 and serve as the sheet discharging portion push the trailing edge of the sheet bundle PA.", "Thus, the sheet bundle PA on the intermediate processing tray 107 is discharged onto the stacking tray 114 in a bundle state.", "Note that, after that, as illustrated in FIG.", "11C, in order to prevent the sheet bundle PA stacked on the stacking tray 114 from being pushed out in the sheet conveyance direction by a sheet bundle to be subsequently discharged, the sheet bundle presser 115 is rotated counterclockwise to press the trailing end of the sheet bundle PA. Then, after the sheet bundle presser 115 completes the sheet bundle pressing operation, when the sheet bundle PA shields the tray HP sensor S241 from light, the tray raising and lowering motor M251 lowers the stacking tray 114 until the tray HP sensor S241 becomes a transmissive state, to thereby determine the sheet surface position.", "The series of operations is repeated, and thus a necessary number of sets of the sheet bundle PA can be discharged onto the stacking tray 114.Note that, during operation, when the stacking tray 114 is lowered to shield the tray lower limit sensor S242 from light, a full stacking state of the stacking tray 114 is noted from the finisher control portion 220 to the CPU circuit portion 200 of the image forming apparatus 900, to thereby suspend the image formation.", "After the sheaves of sheets on the stacking tray 114 are removed, the stacking tray 114 is raised until the stacking tray 114 shields the tray HP sensor S241 from light.", "Then, the stacking tray 114 is lowered so that the tray HP sensor S241 becomes a transmissive state to determine the position of the surface of the stacking tray 114 again.", "With this, the image formation of the image forming apparatus 900 is restarted.", "By the way, in this embodiment, as described above and illustrated in FIG.", "3, the binding portion 100A includes the stapler 110 and the staple-less binding unit 102.Then, when the binding mode is selected, the user selects one of a staple job for binding the sheets with the staple, and a staple-less binding job for binding the sheets by staple-less binding.", "Then, for example, when the user selects the staple job, the finisher control portion 220 drives the STP moving motor M258 to move the stapler 110 from the HP illustrated in FIG.", "3 referred to above to a near side binding position with respect to the sheet P illustrated in FIG.", "12A.", "The sheet discharged by the delivery rollers 103 under this state is applied with a force by the pull-in paddle 106 in a direction opposite to the sheet conveyance direction so that the trailing edge of the sheet P returns back to the trailing edge stopper 108.After the trailing edge of the sheet P is returned back to the trailing edge stopper 108, the near side aligning plate 109a and the far side aligning plate 109b correct the sheet P in the width direction.", "After that, the knurled belt 117 performs returning in the sheet conveyance direction.", "This aligning operation is performed correspondingly to the number of sheets to be subjected to the binding process, and then the stapler 110 performs the binding process with a staple with respect to a staple position 1104 of the sheets P. After that, the sheet bundle subjected to the binding process on the intermediate processing tray 107 is discharged onto the stacking tray 114 by the trailing edge assist 112.Note that, in this embodiment, the case where the sheet P is subjected to near side binding will be described, but when the stapler 110 is caused to wait on the far side of the apparatus main body as illustrated in FIG.", "12B, far side binding becomes possible.", "Further, in a case of two-position binding, the stapler 110 is first caused to wait at the staple position on one side as illustrated in FIG.", "12C, and then the sheet bundle is subjected to the staple process.", "Next, the stapler 110 is moved by the STP moving motor M258 to another binding position indicated by the broken lines to subject the sheet bundle to the staple process.", "In this manner, the two-position binding can be performed.", "In other words, in this embodiment, the stapler 110 is movable along the sheet bundle PA, and capable of performing a binding process at a plurality of binding positions corresponding to each binding mode.", "On the other hand, when the user selects the staple-less binding job, first, the far side aligning plate 109b serving as a first aligning plate moves from an initial position illustrated in FIG.", "3 referred to above to wait at a position at which the staple-less binding unit 102 on the far side (the side of the second binding unit) of the apparatus main body illustrated in FIG.", "13 can perform staple-less binding.", "Under this state, the sheet P discharged onto the intermediate processing tray 107 is applied with a force by the pull-in paddle 106 in a direction opposite to the sheet conveyance direction.", "Further, with the conveyance by the knurled belt 117, the sheet trailing edge is returned back to the trailing edge stopper 108.Next, after the sheet trailing edge is returned back to the trailing edge stopper 108 as described above, the near side aligning plate 109a serving as a second aligning plate is moved in the width direction so that the sheet is hit against the far side aligning plate 109b.", "In this manner, the sheet is subjected to the aligning operation in the width direction.", "With this, at the time of the staple-less binding job, the sheet bundle can be aligned at an alignment position (second alignment position) on the staple-less binding unit side with respect to an alignment position (first alignment position) when the stapler 110 performs the binding process illustrated in FIGS.", "12A, 12B, and 12C referred to above.", "After that, the knurled belt 117 performs returning in the sheet conveyance direction.", "Then, the aligning operation is performed with respect to a predetermined number of sheets to be subjected to the binding process.", "After that, the staple-less binding unit 102 performs the binding operation to the sheet bundle, and thus the staple-less binding process is performed at a predetermined binding position 102a.", "As described above, in this embodiment, the second alignment position is set as the binding process position for the staple-less binding unit 102.The staple-less binding unit 102 is arranged outside a moving region of the stapler 110 (a region in which sheets having the maximum width are to be stacked).", "By the way, in this embodiment, as illustrated in FIG.", "3 referred to above, the staple-less binding unit 102 is arranged on upstream with respect to the stapler 110 in a moving direction in which the sheet moved by the pull-in paddle 106 and the knurled belt 117 as a moving unit.", "Further, as described above, the opening 141 of the staple-less binding unit 102 has a gap in a sheet thickness direction, which is smaller than that of the opening 140 of the stapler 110.Therefore, when the staple-less binding unit 102 is arranged on upstream with respect to the stapler 110 in the sheet moving direction, depending on the arrangement position, in a case of binding the sheet bundle by the stapler 110, the staple-less binding unit 102 may interfere with the sheet bundle to be bound.", "Therefore, in this embodiment, the staple-less binding unit 102 is arranged outside a region in which sheets having the maximum width, which are to be subjected to the binding process by the stapler 110, are to be stacked (see FIGS.", "12A to 12C).", "In other words, in this embodiment, when the stapler 110 performs the binding process, the staple-less binding unit 102 is arranged at a position shifted in the width direction from a region on the intermediate processing tray (a sheet stacking portion), through which the sheets discharged by the delivery rollers 103 pass.", "In other words, the staple-less binding unit 102 is arranged in a position at which the sheets moved into the opening 140 do not enter the opening 141 of the staple-less binding unit 102.With this, when the stapler 110 performs the binding of the sheet bundle, it is possible to prevent the staple-less binding unit 102 having the opening 141 with a gap in the sheet thickness direction, which is smaller than that of the opening 140 of the stapler 110, from interfering with the sheet bundle to be bound by the stapler 110.As a result, even when the stapler 110 and the staple-less binding unit 102 which differ in opening height are used, the finisher 100 can perform the binding process without using a selective moving mechanism and without limiting the number of sheets to be bound to be smaller than the ability of the binding unit.", "In other words, the finisher 100 can perform the binding process without upsizing the apparatus and lowering the binding process efficiency.", "By the way, in the description above, the HP of the stapler 110 is set on the near side of the apparatus main body 900A, but the present invention is not limited thereto.", "The HP of the stapler 110 may be set on the far side of the apparatus main body 900A.", "Next, a second embodiment of the present invention will be described, in which the HP of the stapler 110 is set on the far side of the apparatus main body 900A.", "FIG.", "14 is a view illustrating a configuration of a binding portion provided in a finisher serving as a sheet processing apparatus according to this embodiment.", "Note that, in FIG.", "14, the same or corresponding parts are denoted by the same reference symbols as those in FIG.", "3 referred to above.", "In FIG.", "14, a staple (STP) HP sensor S247A detects the home position (HP) of the movable stapler 110.The STP HP sensor S247A is provided on the far side of the apparatus main body 900A.", "Then, when user selects the staple job, the finisher control portion 220 drives the STP moving motor M258 to move the stapler 110 from the HP illustrated in FIG.", "14 to the near side binding position with respect to the sheet P illustrated in FIG.", "12A referred to above.", "Further, in the case of the far side binding, the stapler 110 is caused to wait at the HP on the far side of the apparatus main body as illustrated in FIG.", "12B referred to above.", "Further, in a case of two-position binding, the stapler 110 is first caused to wait at the staple position on one side indicated by the broken lines as illustrated in FIG.", "12C referred to above, and then the sheet bundle is subjected to the staple process.", "Next, the stapler 110 is moved by the STP moving motor M258 to another binding position to subject the sheet bundle to the staple process.", "In this manner, the two-position binding can be performed.", "On the other hand, when the user selects the staple-less binding job, first, the far side aligning plate 109b moves from the initial position illustrated in FIG.", "3 referred to above to wait at a position at which the staple-less binding unit 102 on the far side (the side of the second binding unit) of the apparatus main body illustrated in FIG.", "15A can perform staple-less binding.", "Under this state, the sheet P discharged onto the intermediate processing tray 107 is applied with a force by the pull-in paddle 106 in a direction opposite to the sheet conveyance direction.", "Further, with the conveyance by the knurled belt 117, the sheet trailing edge is returned back to the trailing edge stopper 108.Next, after the sheet trailing edge is returned back to the trailing edge stopper 108 as described above, the near side aligning plate 109a is moved in the width direction so that the sheet is hit against the far side aligning plate 109b.", "In this manner, the sheet is subjected to the aligning operation in the width direction.", "After that, the knurled belt 117 performs returning in the sheet conveyance direction.", "Then, the aligning operation is performed with respect to a predetermined number of sheets to be subjected to the binding process.", "After that, the staple-less binding unit 102 performs the binding operation to the sheet bundle, and thus the staple-less binding process is performed at a predetermined binding position.", "Note that, also in this embodiment, the staple-less binding unit 102 is arranged outside a region in which sheets having the maximum width, which are to be subjected to the binding process by the stapler 110, are to be stacked.", "When the staple-less binding unit 102 is arranged at such a position, it is possible to prevent the sheet bundle to be bound by the stapler 110 from entering the opening of the staple-less binding unit 102.By the way, in the case where the stapler 110 is located at the HP in the vicinity of the staple-less binding unit 102 as in this embodiment, when the staple-less binding is performed, the jaw portion 1103 of the stapler 110 interferes with the sheets to be subjected to the staple-less binding, and hence the sheets cannot be aligned.", "Therefore, when the staple-less binding is performed, the stapler 110 is moved to a position at which the jaw portion 1103 does not interfere with the sheets to be subjected to the staple-less binding.", "Specifically, when the staple-less binding is performed, before the sheets are conveyed, the stapler 110 is moved from the HP illustrated in FIG.", "15A to a position for near side binding (solid line) or a position for two-position binding (broken lines) illustrated in FIG.", "15B.", "Then, when the staple-less binding is performed, by moving the stapler 110 to positions described above, the staple-less binding unit 102 can align the sheets without being interfered with the stapler 110.Note that, the retracting position of the stapler 110 is not limited to such positions, and may be any position as long as the jaw portion 1103 does not interfere with the sheets to be subjected to the staple-less binding, in other words, the binding process of the staple-less binding unit 102 is not inhibited.", "Note that, FIG.", "16 is a flow chart illustrating the binding operation of such a finisher 100 according to this embodiment.", "When the job is started, the CPU circuit portion 200 of the image forming apparatus 900 sends, to the finisher control portion 220, information on any one of a job of performing binding of sheets with the staple and a job of performing binding of sheets by staple-less binding.", "In this case, when the job is a staple job (YES in Step S200), the stapler 110 is moved by the STP moving motor M258 to the near side binding position, the far side binding position, or the two-binding position illustrated in FIGS.", "12A, 12B, and 12C referred to above, and caused to wait at the corresponding position.", "Next, after the stapler 110 is moved to the waiting position as described above (Step S201), at the processing portion 139, a predetermined number of sheets to be subjected to the binding process are stacked and aligned (Step S202).", "Then, after the alignment of the last sheet as the final sheet is completed (YES in Step S203), the stapler 110 performs the staple operation (Step S204).", "With this, the sheet bundle is subjected to the staple process.", "Note that, after that, it is determined whether or not the job has been completed with this process (Step S205), and until the job is completed (NO in Step S205), Steps S200 to S204 are repeated.", "When the job is completed (YES in Step S205), the binding operation is ended.", "On the other hand, when the job is an eco staple, that is, when the job is the staple-less binding job (NO in Step S200), the stapler 110 is moved from the HP illustrated in FIG.", "14 to the near side binding position illustrated in FIG.", "15B (Step S209).", "After that, the far side aligning plate 109b is caused to wait at the waiting position on the far side of the apparatus main body, and the near side aligning plate 109a is moved in the width direction.", "With this, at the processing portion 139, a predetermined number of sheets to be subjected to the binding process are stacked and aligned (Step S210).", "Then, after the alignment of the last sheet as the final sheet is completed (YES in Step S211), the staple-less binding unit 102 performs the eco staple operation (Step S212).", "With this, the sheet bundle is subjected to the staple-less binding process.", "Then, it is determined whether or not the job has been completed with this process (Step S205), and until the job is completed (NO in Step S205), Steps S200 and S209 to S212 are repeated.", "When the job is completed (YES in Step S205), the binding operation is ended.", "In the case where the HP of the stapler 110 is set on the far side of the apparatus main body 900A as described above, when the staple-less binding job is performed, the stapler 110 is moved to a position at which the stapler 110 does not interfere with the sheets to be subjected to staple-less binding.", "In other words, in the case of the staple-less binding job, the stapler 110 is moved to such a position in which the stapler 110 does not inhibit the staple-less binding of the staple-less binding unit 102.With this, even when the stapler 110 and the staple-less binding unit 102 which differ in opening height are used, the finisher 100 can perform the binding process without upsizing the apparatus and lowering the binding process efficiency.", "Note that, in the above, there is described a case in which, when the job is the eco staple, the near side aligning plate 109a is moved for each sheet so that the sheet abuts against the far side aligning plate 109b to form the sheet bundle, and the binding is performed at the position at which the sheet bundle is formed.", "However, the present invention is not limited thereto.", "For example, the sheet bundle may be formed at a position in which the sheet bundle does not enter the opening 141 in the eco staple, and then the near side aligning plate 109a and the far side aligning plate 109b may be moved while maintaining a gap of a sheet width, to thereby introduce the sheets into the opening 141.Next, a third embodiment of the present invention will be described with reference to FIGS.", "17A, 17B, and 18 and a flow chart illustrated in FIG.", "19.Note that, in FIGS.", "17A, 17B, and 18, the same or corresponding parts are denoted by the same reference symbols as those in FIGS.", "12A to 12C and 14 referred to above.", "When the job is started, the CPU circuit portion 200 of the image forming apparatus 900 sends, to the finisher control portion 220, information on any one of a job of performing binding of sheets with the staple and a job of performing binding of sheets by staple-less binding.", "In this case, when the job is a staple job (YES in Step S300), the stapler 110 is moved by the STP moving motor M258 to the near side binding position, the far side binding position, or the two-binding position illustrated in FIGS.", "12A, 12B, and 12C referred to above, and caused to wait at the corresponding position.", "Next, after the stapler 110 is moved to the waiting position as described above (Step S301), at the processing portion 139, a predetermined number of sheets to be subjected to the binding process are stacked and aligned (Step S302).", "Then, after the alignment of the last sheet as the final sheet is completed (YES in Step S303), the stapler 110 performs the staple operation (Step S304).", "With this, the sheet bundle is subjected to the staple process.", "Note that, after that, it is determined whether or not the job has been completed with this process (Step S305), and until the job is completed (NO in Step S305), Steps S300 to S304 are repeated.", "When the job is completed (YES in Step S305), the binding operation is ended.", "On the other hand, when the job is an eco staple, that is, when the job is the staple-less binding job (NO in Step S300), the stapler 110 is moved from the HP illustrated in FIG.", "14 to the near side binding position illustrated in FIG.", "17A (Step S309).", "After that, the near side aligning plate 109a and the far side aligning plate 109b are caused to wait at positions (separate positions) separated by a predetermined amount from the end portions of the discharged sheet P. After that, the aligning plates 109a and 109b approach to positions abutting against the end portions of the sheet P illustrated in FIG.", "17B (abutment positions).", "Thus, the sheets are aligned.", "This operation is performed every time the sheet P is discharged.", "Thus, at the processing portion 139, a predetermined number of sheets to be subjected to binding process are stacked and aligned (Step S310).", "Then, after the alignment of the last sheet as the final sheet is completed (YES in Step S311), as illustrated in FIG.", "18, the near side aligning plate 109a and the far side aligning plate 109b move toward the staple-less binding unit 102 while bilaterally constraining both ends of the sheet bundle PA. After the sheet bundle PA is moved by the movement of the near side aligning plate 109a and the far side aligning plate 109b as described above (Step S312), the staple-less binding unit 102 performs the eco staple operation (Step S313).", "With this, the sheet bundle is subjected to the staple-less binding process.", "Then, it is determined whether or not the job has been completed with this process (Step S305), and until the job is completed (NO in Step S305), Steps S300 and S309 to S313 are repeated.", "When the job is completed (YES in Step S305), the binding operation is ended.", "Note that, in the above, there is described a case in which the staple-less binding unit 102 has a tooth shape to form irregularities in the sheet, but the present invention is not limited thereto.", "For example, as long as the staple-less binding unit has an opening with a gap in the sheet thickness direction, which is smaller than that of the opening of the stapler, the staple-less binding unit may form a half-blanking shape in the sheets P as illustrated in FIG.", "20.While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments.", "The scope of the following claims is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures and functions.", "This application claims the benefit of Japanese Patent Application No.", "2012-207101, filed Sep. 20, 2012, and Japanese Patent Application No.", "2013-165554, filed Aug. 8, 2013, which are hereby incorporated by reference herein in their entirety." ] ]
Patent_15874219
[ [ "ALTERNATIVE PLACEMENT OF THERMAL SENSORS ON BIPOLAR ELECTRODE", "A medical device for tissue ablation may include a catheter shaft, an expandable member disposed on or coupled to the catheter shaft, and a plurality of elongate electrode assemblies each constructed as a flexible circuit.", "The expandable member may be configured to shift between an unexpanded configuration and an expanded configuration.", "The plurality of electrode assemblies may be disposed on an outer surface of the expandable member.", "Each of the plurality of electrode assemblies may include a temperature sensor aligned with two or more electrodes." ], [ "1.A medical device for tissue ablation, comprising: a catheter shaft; an expandable member coupled to the catheter shaft, the expandable member being capable of shifting between an unexpanded configuration and an expanded configuration; and a plurality of elongate electrode assemblies each constructed as a flexible circuit, the plurality of elongate electrode assemblies disposed on an outer surface of the expandable member; wherein each of the plurality of elongate electrode assemblies includes one or more temperature sensors and a plurality of pairs of electrodes; and wherein the one or more temperature sensors is positioned between the plurality of pairs of electrodes.", "2.The medical device of claim 1, wherein the one or more temperature sensors positioned between the plurality of pairs of electrodes is positioned on a plurality of electrode pads.", "3.The medical device of claim 1, wherein the one or more temperature sensors positioned between the plurality of pairs of electrodes is positioned on the outer surface of the expandable member.", "4.The medical device of claim 1, wherein each of the plurality of elongate electrode assemblies is formed from a multiple-layer structure comprising a first laminated sheet including a first polymer layer laminated to a first conductive layer and a second laminated sheet including a second polymer layer laminated to a second conductive layer.", "5.The medical device of claim 4, wherein the first and second laminated sheets are arranged with the first conductive layer of the first laminated sheet attached to the second polymer layer of the second laminated sheet.", "6.The medical device of claim 4, wherein the one or more temperature sensors are attached to the second conductive layer of the second laminated sheet and are positioned at a lower surface of the multiple-layer structure facing radially toward the expandable member.", "7.The medical device of claim 4, wherein the plurality of pairs of electrodes are formed in the first polymer layer of the first laminated sheet and are positioned at an upper surface of the multiple-layer structure facing radially away from the expandable member.", "8.The medical device of claim 4, wherein a via connects the first and second conductive layers.", "9.The medical device of claim 4, wherein the first and second conductive layers are copper layers.", "10.The medical device of claim 1, wherein each pair of the plurality of pairs of electrodes includes an active electrode and ground electrode, and wherein each of the plurality of elongate electrode assemblies includes a plurality of the active electrodes, a plurality of the ground electrodes, and a plurality of the one or more temperature sensors.", "11.The medical device of claim 1, wherein each pair of the plurality of pairs of electrodes includes an active electrode and a ground electrode, and wherein each of the plurality of elongate electrode assemblies includes a plurality of active electrodes aligned linearly, a plurality of the ground electrodes aligned linearly and spaced apart from the plurality of the active electrodes, and a plurality of the one or more of the temperature sensors positioned at least partially under the plurality of the ground electrodes.", "12.A medical device for tissue ablation, comprising: an expandable member configured to be coupled to a catheter shaft; and a plurality of elongate electrode assemblies each constructed as a flexible circuit, the plurality of elongate electrode assemblies disposed on an outer surface of the expandable member; wherein each of the plurality of elongate electrode assemblies includes one or more temperature sensors and a plurality of pairs of electrodes; wherein the one or more temperature sensors is positioned between the plurality of pairs of electrodes; wherein each pair of the plurality of pairs of electrodes comprises an active electrode and a ground electrode; and wherein at least one of the one or more temperature sensors is positioned between the active electrode and the ground electrode of at least one pair of the plurality of pairs of electrodes.", "13.The medical device of claim 12, wherein the plurality of the one or more temperature sensors positioned between the plurality of pairs of electrodes is positioned on a plurality of electrode pads.", "14.The medical device of claim 12, wherein the plurality of the one or more temperature sensors positioned between the plurality of pairs of electrodes is positioned on the outer surface of the expandable member.", "15.The medical device of claim 12, wherein each of the plurality of elongate electrode assemblies is formed from a multiple-layer structure comprising a first laminated sheet including a first polymer layer laminated to a first conductive layer and a second laminated sheet including a second polymer layer laminated to a second conductive layer.", "16.The medical device of claim 12, wherein each of the plurality of elongate electrode assemblies includes a plurality of the active electrodes, a plurality of the ground electrodes, and a plurality of the one or more temperature sensors, wherein each of the plurality of the one or more temperature sensors is positioned at least partially under one of the ground electrodes.", "17.The medical device of claim 12, wherein each of the plurality of elongate electrode assemblies includes a plurality of the active electrodes aligned linearly, a plurality of the ground electrodes aligned linearly and spaced apart from the plurality of the active electrodes, and a plurality of the one or more temperature sensors positioned at least partially under the plurality of the ground electrodes.", "18.A method of applying thermal energy to tissue, comprising: inserting an expandable member having a plurality of pairs of electrodes within a patient; expanding the expandable member to an expanded state; activating the plurality of electrode pairs; and monitoring the temperature between the pairs of electrodes by measuring a temperature from each of one or more thermistors disposed between the pairs of electrodes.", "19.The method of claim 18, wherein at least one of the one or more thermistors is disposed between each pair of the plurality of pairs of electrodes, and further comprising monitoring the temperature within each pair of electrodes by measuring a temperature from at least one of the one or more thermistors disposed therebetween.", "20.The method of claim 18, wherein the pairs of electrodes are arranged side-by-side and longitudinally along the expandable member, and inserting the expandable member is performed in an unexpanded state with the expandable member folded at least between the pairs of electrodes." ], [ "<SOH> BACKGROUND <EOH>A wide variety of intracorporeal medical devices have been developed for medical use, for example, intravascular use.", "Some of these devices include guidewires, catheters, and the like.", "These devices are manufactured by any one of a variety of different manufacturing methods and may be used according to any one of a variety of methods.", "Of the known medical devices and methods, each has certain advantages and disadvantages.", "There is an ongoing need to provide alternative medical devices as well as alternative methods for manufacturing and using medical devices." ], [ "<SOH> BRIEF SUMMARY <EOH>A medical device for tissue ablation may include a catheter shaft, an expandable balloon disposed on the catheter shaft, where the balloon may be capable of shifting between an unexpanded configuration and an expanded configuration.", "The medical device may include a plurality of elongate electrode assemblies each constructed as a flexible circuit, the plurality of electrode assemblies may each include a plurality of electrodes in at least first and second spaced apart arrays, the plurality of electrode assemblies may be disposed on an outer surface of the balloon.", "Each of the plurality of electrode assemblies may include one or more temperature sensor aligned with two or more electrodes within an array.", "A medical device for tissue ablation may include a catheter shaft, an expandable member coupled to the catheter shaft, and a plurality of elongate electrode assemblies each constructed as a flexible circuit.", "The expandable member may be capable of shifting between an unexpanded configuration and an expanded configuration.", "The plurality of electrode assemblies may be disposed on an outer surface of the expandable member, and each of the plurality of electrode assemblies may include at least one temperature sensor positioned under at least one electrode.", "A medical device for tissue ablation within a body passageway may include a catheter shaft having a longitudinal axis, an expandable member coupled to the catheter shaft, and a plurality of elongate electrode assemblies each constructed as a flexible circuit.", "The expandable member may be capable of shifting between an unexpanded configuration and an expanded configuration, and the plurality of electrode assemblies may be bonded to an outer surface of the expandable member.", "Each of the plurality of electrode assemblies may include a plurality of active electrodes, a plurality of ground electrodes, and one or more temperature sensor.", "The temperature sensor may be linearly aligned with the plurality of ground electrodes.", "The above summary of some embodiments is not intended to describe each disclosed embodiment or every implementation of the present disclosure.", "The Figures, and Detailed Description, which follow, more particularly exemplify these embodiments." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This is a continuation application of U.S. application Ser.", "No.", "14,611,755, filed on Feb. 2, 2015, which claims priority under 35 U.S.C.", "§ 119 to U.S.", "Provisional Application Ser.", "No.", "61/935,685, filed Feb. 4, 2014, the entirety of which is incorporated herein by reference.", "TECHNICAL FIELD The present disclosure pertains to medical devices, and methods for manufacturing medical devices.", "More particularly, the present disclosure pertains to medical devices for tissue ablation.", "BACKGROUND A wide variety of intracorporeal medical devices have been developed for medical use, for example, intravascular use.", "Some of these devices include guidewires, catheters, and the like.", "These devices are manufactured by any one of a variety of different manufacturing methods and may be used according to any one of a variety of methods.", "Of the known medical devices and methods, each has certain advantages and disadvantages.", "There is an ongoing need to provide alternative medical devices as well as alternative methods for manufacturing and using medical devices.", "BRIEF SUMMARY A medical device for tissue ablation may include a catheter shaft, an expandable balloon disposed on the catheter shaft, where the balloon may be capable of shifting between an unexpanded configuration and an expanded configuration.", "The medical device may include a plurality of elongate electrode assemblies each constructed as a flexible circuit, the plurality of electrode assemblies may each include a plurality of electrodes in at least first and second spaced apart arrays, the plurality of electrode assemblies may be disposed on an outer surface of the balloon.", "Each of the plurality of electrode assemblies may include one or more temperature sensor aligned with two or more electrodes within an array.", "A medical device for tissue ablation may include a catheter shaft, an expandable member coupled to the catheter shaft, and a plurality of elongate electrode assemblies each constructed as a flexible circuit.", "The expandable member may be capable of shifting between an unexpanded configuration and an expanded configuration.", "The plurality of electrode assemblies may be disposed on an outer surface of the expandable member, and each of the plurality of electrode assemblies may include at least one temperature sensor positioned under at least one electrode.", "A medical device for tissue ablation within a body passageway may include a catheter shaft having a longitudinal axis, an expandable member coupled to the catheter shaft, and a plurality of elongate electrode assemblies each constructed as a flexible circuit.", "The expandable member may be capable of shifting between an unexpanded configuration and an expanded configuration, and the plurality of electrode assemblies may be bonded to an outer surface of the expandable member.", "Each of the plurality of electrode assemblies may include a plurality of active electrodes, a plurality of ground electrodes, and one or more temperature sensor.", "The temperature sensor may be linearly aligned with the plurality of ground electrodes.", "The above summary of some embodiments is not intended to describe each disclosed embodiment or every implementation of the present disclosure.", "The Figures, and Detailed Description, which follow, more particularly exemplify these embodiments.", "BRIEF DESCRIPTION OF THE DRAWINGS The disclosure may be more completely understood in consideration of the following detailed description in connection with the accompanying drawings, in which: FIG.", "1 is a schematic view of an example tissue ablation device; FIGS.", "2A, 2B, and 3 are partial top views of prior art electrode assemblies; FIG.", "4 is a partial top view of an exemplary electrode assembly; FIG.", "5 is a partial top view of an exemplary electrode assembly; FIGS.", "6A and 6B are top views of exemplary electrode assemblies; FIG.", "7 is a perspective view of an exemplary expandable member of a tissue ablation device; FIG.", "8 is a top view of a portion of an exemplary electrode assembly; FIG.", "9 is a partial cross-sectional view of FIG.", "8; FIGS.", "10A, 10B, 11, 12, and 13 are partial top views of exemplary electrode assemblies; FIG.", "14 is a partial cross-sectional view of an exemplary electrode assembly; FIGS.", "15A, 15B, and 15C are temperature profiles taken through cross-sections A-A, B-B-, and C-C, respectively, of the assembly of FIG.", "14; and FIG.", "16 is a graphical representation of the temperature profile at varying distances from the center of an exemplary electrode.", "While the disclosure is amenable to various modifications and alternative forms, specifics thereof have been shown by way of example in the drawings and will be described in detail.", "It should be understood, however, that the intention is not to limit the invention to the particular embodiments described.", "On the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the disclosure.", "DETAILED DESCRIPTION The following description should be read with reference to the drawings, which are not necessarily to scale, wherein like reference numerals indicate like elements throughout the several views.", "The detailed description and drawings are intended to illustrate but not limit the claimed invention.", "Those skilled in the art will recognize that the various elements described and/or shown may be arranged in various combinations and configurations without departing from the scope of the disclosure.", "The detailed description and drawings illustrate example embodiments of the claimed invention.", "For the following defined terms, these definitions shall be applied, unless a different definition is given in the claims or elsewhere in this specification.", "All numeric values are herein assumed to be modified by the term “about,” whether or not explicitly indicated.", "The term “about”, in the context of numeric values, generally refers to a range of numbers that one of skill in the art would consider equivalent to the recited value (i.e., having the same function or result).", "In many instances, the term “about” may include numbers that are rounded to the nearest significant figure.", "Other uses of the term “about” (i.e., in a context other than numeric values) may be assumed to have their ordinary and customary definition(s), as understood from and consistent with the context of the specification, unless otherwise specified.", "The recitation of numerical ranges by endpoints includes all numbers within that range, including the endpoints (e.g.", "1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, and 5).", "As used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include plural referents unless the content clearly dictates otherwise.", "As used in this specification and the appended claims, the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.", "It is noted that references in the specification to “an embodiment”, “some embodiments”, “other embodiments”, etc., indicate that the embodiment(s) described may include a particular feature, structure, or characteristic, but every embodiment may not necessarily include the particular feature, structure, or characteristic.", "Moreover, such phrases are not necessarily referring to the same embodiment.", "Further, when a particular feature, structure, or characteristic is described in connection with an embodiment, it would be within the knowledge of one skilled in the art to effect such feature, structure, or characteristic in connection with other embodiments, whether or not explicitly described, unless clearly stated to the contrary.", "That is, the various individual elements described below, even if not explicitly shown in a particular combination, are nevertheless contemplated as being combinable or arrangable with each other to form other additional embodiments or to complement and/or enrich the described embodiment(s), as would be understood by one of ordinary skill in the art.", "Certain treatments are aimed at tissue ablation.", "In some examples, tissue ablation may include the temporary or permanent interruption or modification of select nerve function.", "In some embodiments, the nerves may be sympathetic nerves.", "One example treatment is renal nerve ablation, which is sometimes used to treat conditions such as or related to hypertension, congestive heart failure, diabetes, or other conditions impacted by high blood pressure or salt retention.", "The kidneys produce a sympathetic response, which may increase the undesired retention of water and/or sodium.", "The result of the sympathetic response, for example, may be an increase in blood pressure.", "Ablating some of the nerves running to the kidneys (e.g., disposed adjacent to or otherwise along the renal arteries) may reduce or eliminate this sympathetic response, which may provide a corresponding reduction in the associated undesired symptoms (e.g., a reduction in blood pressure).", "Some embodiments of the present disclosure relate to a power generating and control apparatus, often for the treatment of targeted tissue in order to achieve a therapeutic effect.", "In some embodiments, the target tissue is tissue containing or proximate to nerves.", "In other embodiments, the target tissue is sympathetic nerves, including, for example, sympathetic nerves disposed adjacent to blood vessels.", "In still other embodiments the target tissue is luminal tissue, which may further comprise diseased tissue such as that found in arterial disease.", "In some embodiments of the present disclosure, the ability to deliver energy in a targeted dosage may be used for nerve tissue in order to achieve beneficial biologic responses.", "For example, chronic pain, urologic dysfunction, hypertension, and a wide variety of other persistent conditions are known to be affected through the operation of nervous tissue.", "For example, it is known that chronic hypertension that may not be responsive to medication may be improved or eliminated by disabling excessive nerve activity proximate to the renal arteries.", "It is also known that nervous tissue does not naturally possess regenerative characteristics.", "Therefore it may be possible to beneficially affect excessive nerve activity by disrupting the conductive pathway of the nervous tissue.", "When disrupting nerve conductive pathways, it is particularly advantageous to avoid damage to neighboring nerves or organ tissue.", "The ability to direct and control energy dosage is well-suited to the treatment of nerve tissue.", "Whether in a heating or ablating energy dosage, the precise control of energy delivery as described and disclosed herein may be directed to the nerve tissue.", "Moreover, directed application of energy may suffice to target a nerve without the need to be in exact contact, as would be required when using a typical ablation probe.", "For example, eccentric heating may be applied at a temperature high enough to denature nerve tissue without causing ablation and without requiring the piercing of luminal tissue.", "However, it may also be desirable to configure the energy delivery surface of the present disclosure to pierce tissue and deliver ablating energy similar to an ablation probe with the exact energy dosage being controlled by a power control and generation apparatus.", "In some embodiments, efficacy of the denervation treatment can be assessed by measurement before, during, and/or after the treatment to tailor one or more parameters of the treatment to the particular patient or to identify the need for additional treatments.", "For instance, a denervation system may include functionality for assessing whether a treatment has caused or is causing a reduction in neural activity in a target or proximate tissue, which may provide feedback for adjusting parameters of the treatment or indicate the necessity for additional treatments.", "Many of the devices and methods described herein are discussed relative to renal nerve ablation and/or modulation.", "However, it is contemplated that the devices and methods may be used in other treatment locations and/or applications where sympathetic nerve modulation and/or other tissue modulation including heating, activation, blocking, disrupting, or ablation are desired, such as, but not limited to: blood vessels, urinary vessels, or in other tissues via trocar and cannula access.", "For example, the devices and methods described herein can be applied to hyperplastic tissue ablation, cardiac ablation, pain management, pulmonary vein isolation, pulmonary vein ablation, tumor ablation, benign prostatic hyperplasia therapy, nerve excitation or blocking or ablation, modulation of muscle activity, hyperthermia or other warming of tissues, etc.", "The disclosed methods and apparatus can be applied to any relevant medical procedure, involving both human and non-human subjects.", "The term modulation refers to ablation and other techniques that may alter the function of affected nerves and other tissue.", "FIG.", "1 is a schematic view of an example sympathetic nerve ablation system 100.System 100 may include a sympathetic nerve ablation device 120.Sympathetic nerve ablation device 120 may be used to ablate nerves (e.g., renal nerves) disposed adjacent to the kidney K (e.g., renal nerves disposed about a renal artery RA).", "In use, sympathetic nerve ablation device 120 may be advanced through a blood vessel such as the aorta A to a position within the renal artery RA.", "This may include advancing sympathetic nerve ablation device 120 through a guide sheath or catheter 14.When positioned as desired, sympathetic nerve ablation device 120 may be activated to activate one or more electrodes (not shown).", "This may include operatively coupling sympathetic nerve ablation device 120 to a control unit 110, which may include an RF generator, so as to supply the desired activation energy to the electrodes.", "For example, sympathetic nerve ablation device 120 may include a wire or conductive member 18 with a first connector 20 that can be connected to a second connector 22 on the control unit 110 and/or a wire 24 coupled to the control unit 110.In at least some embodiments, the control unit 110 may also be utilized to supply/receive the appropriate electrical energy and/or signal to activate one or more sensors disposed at or near a distal end of sympathetic nerve ablation device 120.When suitably activated, the one or more electrodes may be capable of ablating tissue (e.g., sympathetic nerves) as described below and the one or more sensors may be used to detect desired physical and/or biological parameters.", "The sympathetic nerve ablation device 120 may include an elongate tubular member or catheter shaft 122.In some embodiments, the elongate tubular member or catheter shaft 122 may be configured to be slidingly advanced over a guidewire or other elongate medical device to a target site.", "In some embodiments, the elongate tubular member or catheter shaft 122 may be configured to be slidingly advanced within a guide sheath or catheter 14 to a target site.", "In some embodiments, the elongate tubular member or catheter shaft 122 may be configured to be advanced to a target site over a guidewire, within a guide sheath or catheter 14, or a combination thereof.", "An expandable member 130 may be disposed at, on, about, or near a distal region of the elongate tubular member or catheter shaft 122.In some embodiments, the expandable member 130 may be a compliant or a non-compliant balloon.", "In some embodiments, the expandable member 130 may be capable of shifting between an unexpanded configuration and an expanded configuration.", "The use of medical devices that include a balloon with one or more electrode assemblies coupled thereto, for example as described herein, may be desirable.", "In some instances, however, the electrode assemblies may include relatively stiff and/or bulky materials or elements.", "Accordingly, when the balloon is deflated following a treatment procedure, the electrode assembly may tend to flatten and/or widen out.", "When so configured, the one or more electrode assemblies, and/or components or edges thereof, might catch on the edge of a guide catheter when proximally retracting the medical device (e.g., including the affixed electrode assemblies) into the guide catheter.", "Disclosed herein are medical devices that include structural features that may reduce the size of an electrode assembly and the likelihood of an electrode assembly or other structures of the medical device “catching” on the end of a guide catheter (or other device) when being retracted, for example, into the guide catheter, thus resulting in reduced withdrawal forces.", "The electrode assemblies may be arranged on the expandable member and each assembly may include one or more of each of a ground electrode 10, a positive electrode 12, and a temperature sensor or thermistor 26.Some prior art electrode pair designs consisted of an electrode pad 70 having a plurality of ground electrodes 10 spaced a few millimeters apart from a plurality of positive electrodes 12, with a thermistor 26 placed in between the electrodes, as shown in FIG.", "2A.", "This allows for accurate temperature sensing when individual electrodes are activated, creating consistent lesions.", "Each individual electrode pair may be activated individually, resulting in staggered treatment around the vessel.", "When the electrode assemblies are placed on a balloon catheter, they may be wired to individually activate around each thermistor, as shown in FIG.", "2B.", "In other applications, more complete and circumferential treatment may be desired.", "In such applications, the electrode pairs may be arranged to fire within pairs, indicated by arrows 50, and in between pairs, indicated by arrows 60.See FIG.", "3.In this scenario, the in between pairs of electrodes do not have thermistors to monitor temperature during activation.", "In order to monitor the temperature of the in-between electrode pairs, additional thermistors 26 may be placed between the electrode pads 70, as shown in FIG.", "4.However, this arrangement requires doubling the number of thermistors, which requires additional surface area on the balloon, may increase the stiffness and profile of the balloon, and requires additional electrical connections to complete the circuit for the additional thermistors.", "The thermistor may be the largest component of the electrode assembly.", "For example, a thermistor may be 0.02 inches (0.0508 centimeter) by 0.04 inches (0.1016 centimeter) and 0.006 inches (0.01524 centimeter) thick.", "When placed between the electrodes, the thermistor may increase the circuit profile and circuit area/mass.", "This structure may also make the expandable member difficult to fold, requiring a larger catheter or sheath.", "In some embodiments, an off-center placement of the temperature sensor on a bipolar electrode structure may reduce the flexible circuit profile and improve balloon foldability, allowing the balloon to pass through a smaller sheath or catheter.", "Moving the temperature sensor off center, or in line with the electrodes may allow the expandable member to fold along the center of the two rows of electrodes without breaking the temperature sensors.", "During retraction of the balloon, the temperature sensor may be pulled back with the spine of the flexible circuit where the electrodes are disposed.", "The middle part between the two rows of electrodes is easier to fold.", "This structure may allow the device to be inserted and withdrawn through a smaller sheath or catheter.", "An example temperature sensor placement is shown in FIG.", "5, which provides full temperature monitoring for both within pair and in-between pair electrode activation without increasing the number of temperature sensors.", "The temperature sensor 226, such as a thermistor, is placed under the ground electrode 210, as shown in FIG.", "5.A layer of insulation material, such as polyimide, may be placed between the ground electrode 210 and the temperature sensor 226.In this arrangement, each temperature sensor 226 may monitor the temperature of within pair electrode activation 50 and in-between pair electrode activation 60, as shown in FIG.", "6A.", "The firing frequency and sequence may be controlled by the generator hardware and software, which may optimize temperature accuracy and may reduce the amount of cross-talk during electrode activation and temperature sensing.", "In some embodiments, longer balloons may be desired.", "The electrode assemblies 140 may be lengthened and additional electrodes 222, including both ground electrodes 210 and active positive electrodes 212, and temperature sensors 226 may be added in arrays extending along the length of the electrode to monitor the temperature across the entire length.", "See FIG.", "6B.", "The electrode arrays may be oriented parallel to each other or at an angle to each other, and may be spaced apart.", "In some embodiments, the area 145 of the electrode assembly between the arrays of electrodes 210, 212 is devoid of circuitry.", "This area 145 devoid of circuitry may aid in folding the electrode assemblies.", "Each electrode assembly 140 may include a plurality of discrete conductive traces layered on top of a base layer 202.The plurality of discrete conductive traces may include a ground electrode trace 210, an active or positive electrode trace 212, and a temperature sensor trace 214.The ground electrode trace 210 may include an elongated ground electrode support 216, and the active electrode trace 212 may include an elongated active electrode support 217.The electrode supports 216, 217 may taper down in width at their proximal ends to provide a desired amount of flexibility, however, this is not required.", "Generally, the curvature of the traces where necking is shown may be optimized to reduce balloon recapture forces and to reduce the potential for any snagging that sharper contours may present.", "The shape and position of the traces may also be optimized to provide dimensional stability to the electrode assembly 140 as a whole, so as to prevent distortion during deployment and use.", "As shown in FIG.", "6B, the ground electrode trace 210 and active electrode trace 212 may each include a plurality of electrodes 222.In some embodiments, at least one electrode may be provided for each electrode trace, however, more or less may be used.", "For example, in some embodiments, three electrodes may be provided for each electrode trace.", "See FIGS.", "11-13.In other embodiments, up to 35 or more electrodes may be provided for each electrode trace, as shown in FIGS.", "7 and 8.The plurality of electrodes 222 may protrude above and/or extend through the insulating layer 206.In some embodiments, the plurality of electrodes 222 may include at least one active electrode and at least one ground electrode attached and/or electrically connected to the elongated active electrode support 217 and the elongated ground electrode support 216, respectively.", "In some embodiments, a plurality of electrodes 222 may be attached and/or electrically connected to the elongated ground electrode support 216, thereby defining a plurality of ground electrodes, and/or the elongated active electrode support 217, thereby defining a plurality of active electrodes.", "In some embodiments, the plurality of electrodes 222 may be from about 0.030 mm thick to about 0.070 mm thick.", "In some embodiments, the plurality of electrodes 222 may be about 0.051 mm thick.", "In some embodiments, the plurality of electrodes 222 may extend about 0.020 mm to about 0.050 mm above the insulating layer 206.In some embodiments, the plurality of electrodes 222 may extend about 0.038 mm above the insulating layer 206.Additionally, each electrode may have radiused corners to reduce tendency to snag on other devices and/or tissue.", "Although the above description of the plurality of electrodes and the traces associated with them has been described in the context of a bi-polar electrode assembly, those of skill in the art will recognize that the same electrode assembly may function in a monopolar mode as well.", "For instance, as one non-limiting example, the plurality of electrodes associated with active electrode trace 212 may be used as monopolar electrodes, with ground electrode trace 210 disconnected during energization of those electrodes.", "In some embodiments, the temperature sensor 226 may have a length of about 0.100 mm to about 2.000 mm, and a width of about 0.100 mm to about 0.800 mm.", "In some embodiments, the temperature sensor 226 may have a length of about 1.000 mm and a width of about 0.500 mm.", "In another embodiment, the temperature sensor may have a length of about 0.2 mm and a width of 0.01 mm.", "Other sizes and/or dimensions are contemplated.", "In some embodiments the electrodes may be canted around the balloon at a slight angle to form a helical configuration around the balloon, which may aid in retraction of the balloon after treatment.", "For example, as shown in FIG.", "7, a plurality of electrode assemblies 140 may be positioned at an angle on the expandable member 130, shown in an expanded state.", "The electrode assemblies 140 may be configured such that energy applied by the electrode assemblies create treatments that may or may not overlap.", "Treatments applied by the electrode assemblies 140 may be circumferentially continuous or non-continuous along longitudinal axis L-L.", "The energy applied by the electrode assemblies, such as the electrode assemblies 140 shown in FIG.", "7, may overlap, longitudinally, circumferentially, and/or in other ways, to at least some extent.", "The electrode assembly 140 shown in FIGS.", "7 and 8 may include a base layer 202 in a rectangular shape.", "This is not intended to be limiting.", "Other shapes are contemplated.", "Additionally, the electrode assembly 140 may include a plurality of openings extending therethrough to provide for added flexibility, and the portions of the assemblies may include rounded or curved corners, transitions and other portions.", "In some instances, the openings and rounded/curved features may enhance the assembly's resistance to delamination from the expandable member 130, as may occur, in some instances, when the expandable member 130 is repeatedly expanded and collapsed (which may also entail deployment from and withdrawal into a protective sheath), such as may be needed when multiple sites are treated during a procedure.", "One example electrode assembly 140 is illustrated in FIG.", "8.As shown in FIG.", "8, each electrode assembly 140 may include one or more temperature sensor 226 on a sensor trace 214, a plurality of electrodes 222, some disposed on a ground array or trace 210 and some disposed on an active or positive array or trace 212.The sensor trace 214 may be centrally located on the electrode assembly 140.In other examples, the sensor trace 214 may be located adjacent one of the arrays or traces 210, 212.Each electrode assembly 140 includes a proximal tail 180 which may include a narrowed region extending off the proximal end of the expandable member 130 and along the catheter shaft 122 to a proximal end of the catheter shaft 122.In some embodiments, the temperature sensor 226 may be a thermistor.", "As shown in FIG.", "9, the temperature sensor 226 may be disposed on a non-tissue contacting side (i.e., bottom side) of the electrode assembly 140.Accordingly, the temperature sensor 226 may be captured between the electrode assembly 140 and the expandable member 130 when incorporated into an ablation device 120.This may be advantageous since surface-mounted electrical components, like thermistors, may typically have sharp edges and corners, which may get caught on tissue and possibly cause problems in balloon deployment and/or retraction.", "This arrangement may also keep soldered connections from making contact with blood, since solder is typically non-biocompatible.", "The size and/or thickness of the electrode assembly 140 at the temperature sensor 226 may create a protrusion extending outward from the outer surface of the expandable member 130.Following a treatment procedure, the expandable member 130 may be collapsed to a collapsed delivery configuration, as discussed further herein, and the ablation device 120 may be retracted within the guide sheath or catheter 14.Significant protrusion(s) may make retraction into the guide sheath or catheter 14 more difficult and/or require a larger diameter guide sheath or catheter 14 than would otherwise be desired.", "Additionally, the protrusion(s) may negatively impact the foldability characteristics of the expandable member 130, both for delivery and for withdrawal.", "FIG.", "9 shows a partial top view of an example electrode assembly 140 and a cross section thereof.", "In the cross-sectional view of FIG.", "9, the bottom of the figure is the portion of the electrode assembly 140 that may face, may be in contact with, and/or may be attached and/or bonded directly to an outer surface of the expandable member 130.In some embodiments, a base layer 202 of insulation which may provide a foundation for the electrode assembly 140.The base layer 202 may be constructed from a polymer such as polyimide, although other materials are contemplated.", "In some embodiments, the base layer 202 may be about 0.010 mm to about 0.020 mm thick.", "In some embodiments, the base layer 202 may be about 0.015 mm thick.", "Other suitable thicknesses are also contemplated.", "For reference, the base layer 202 may form the majority of the bottom side of the electrode assembly 140 that may face, may be in contact with, and/or may be attached and/or bonded directly to the outer surface of the expandable member 130.A first conductive layer 204 may include a plurality of discrete conductive traces layered on the base layer 202.In some embodiments, the plurality of discrete conductive traces may be separated laterally by a non-conductive material.", "The plurality of discrete conductive traces of the conductive layer 204 may include, for example, a layer of electrodeposited copper or rolled-annealed copper.", "Other suitable conductive materials are also contemplated.", "In some embodiments, the conductive layer 204 and/or the plurality of discrete conductive traces may be about 0.010 mm to about 0.030 mm thick.", "In some embodiments, the conductive layer 204 and/or the plurality of discrete conductive traces may be about 0.018 mm thick.", "Other suitable thicknesses are also contemplated.", "The first conductive layer 204 may be etched to form the positive and ground connection for the temperature sensor 226, which may be placed over the first conductive layer.", "A second conductive layer 304 may be disposed over the base layer 202, and an insulating layer 206 may be discretely or continuously layered on top of the second conductive layer 304, such that the second conductive layer 304 may be fluidly sealed between the base layer 202 and the insulating layer 206.In other words, the insulating layer 206 may form a top side or surface of the electrode assembly 140 that may face away from the outer surface of the expandable member 130.The relationship between the base layer 202, the first conductive layer 204, the second conductive layer 304, and the insulating layer 206 is illustrative, and other constructions are contemplated.", "Like the base layer 202, the insulating layer 206 may be constructed from a polymer such as polyimide, although other materials are contemplated.", "In some embodiments, the insulating layer 206 may be from about 0.010 mm thick to about 0.020 mm thick.", "In some embodiments, the insulating layer 206 may be about 0.013 mm thick.", "Other suitable thicknesses are also contemplated.", "In some embodiments, the insulating layer 206 may be a complete or partial polymer coating, such as PTFE or silicone.", "Other materials are also contemplated.", "The electrode assembly 140 may be constructed as a flexible circuit having a plurality of layers.", "Such layers may be continuous or non-contiguous (i.e., made up of discrete portions).", "The electrode assembly 140 may be a multiple layer structure with an electrode 222 on an upper surface (away from the expandable member) and a temperature sensor such as a temperature sensor 226 on a lower surface (against the expandable member).", "The electrode assembly 140 may include one or more layers of polymer and one or more layers of a conductive material.", "As shown in cross-section in FIG.", "9, the electrode assembly 140 may include two polymer layers 202, 206, two conductive layers 204, 304, a temperature sensor 226, and an electrode 222.The polymer and conductive layers may be laminated sheets of a polymer layer 202, 206 adhesively bonded to a conductive layer 204, 304.In some embodiments, two such sheets may be bonded together with an adhesive layer 205.As shown in FIG.", "9, two polymer/conductive sheets may be bonded together with a polymer side against a conductive side, resulting in an alternating polymer 206-conductive 304-adhesive 205-polymer 202-conductive 204 structure, when a cross-section is taken starting with the upper surface (away from the expandable member).", "The second conductive layer 304 may be etched to form traces for the ground and positive electrode 222 pairs.", "A via 204v may be created to connect the electrode ground trace of the second conductive layer 304 to the temperature sensor 226 and ground trace of the first conductive layer 204.The temperature sensor 226 may be soldered onto the first conductive layer 204.The insulation layer 206 may be skived to form a recess 208 to allow for gold plating to form gold electrodes 222.In other embodiments, shown in FIG.", "10A, one of the ground electrode recesses may be removed and the temperature sensor 226 may be positioned in the region where the recess would have been.", "The recess 208 may be oriented in any direction.", "The first conductive layer 204 may be designed to share the ground trace 210 with the temperature sensor 226 while a new trace may be formed for the positive connection of the temperature sensor.", "For longer electrodes that may require more temperature sensors, the temperature sensors may be positioned along the ground trace 210 and may be wired in parallel with each other as shown in FIG.", "10B.", "Alternatively, when multiple temperature sensors are used, they may be wired separately (not shown).", "In some embodiments, the electrode assembly(s) 140 may be disposed along or otherwise define pre-determined fold lines along which the expandable member 130 may fold after deflation.", "In some embodiments, the pre-determined fold lines may aid in re-folding of the expandable member 130.In some embodiments, the electrode assembly(s) 140 may be substantially linear, extending along or at an angle to the longitudinal axis L-L along the entire length of the expandable member 130.In some embodiments, the electrode assemblies may extend parallel to the longitudinal axis in a proximal region, and then be bent into an angled orientation in a distal region (not shown).", "The electrode assembly(s) 140 may cause the balloon to fold along the lines of the electrode assembly(s) 140, reducing the withdrawal force needed to withdraw the ablation device 120 into the guide sheath or catheter 14, and allowing the use of a smaller diameter guide sheath.", "For example, a 6 Fr or 7 Fr guide catheter 14 may be used, providing advantages in certain procedures, (e.g., renal procedures), where 8 Fr guide catheters have been previously used.", "The electrode assembly(s) 140 may also reduce shear force or improve balloon refold profile efficiency, thereby reducing delamination of the electrode assembly(s) 140 from the expandable member 130.In some embodiments, the electrode assemblies 140 include a single row or array of positive electrodes 212 and a single row or array of ground electrodes 210, as shown in FIG.", "8.In other embodiments, the electrode assemblies 340, 440 may include longitudinally spaced apart electrode pads 308, 336 and 408, 436, as shown in FIGS.", "11A and 11B.", "Moving proximally from the distal electrode pad 308, 408, the combined base layer 202, conductive layer 304, and insulating layer 206 may reduce in lateral width to an intermediate tail 328, 428.Continuing to move proximally from the intermediate tail 328, 428, the combined base layer 202, conductive layer 304, and insulating layer 206 may increase in lateral width to form a proximal electrode pad 336, 436.The proximal electrode pad 336, 436 may be constructed similarly to the distal electrode pad 308, 408.However, as shown, the proximal electrode pad 336, 436 may be laterally offset from the distal electrode pad 308, 408 with respect to a central longitudinal axis extending along the electrode assembly 340, 440.From the proximal electrode pad 336, 436, the combined base layer 202, conductive layer 304, and insulating layer 206 may reduce in lateral width to form a proximal tail 338, 438.The proximal tail 338, 438 may include connectors (not shown) to enable coupling to one or more sub-wiring harnesses and/or connectors and ultimately to control unit 110.Each of these lines may be extended along parallel respective axes with respect to the central axis of the electrode assembly 340, 440.The electrode assembly 340, 440 may have a symmetric or an asymmetric arrangement of the distal electrode pad 308, 408 and proximal electrode pad 336, 436, about the central axis of the electrode assembly 340, 440.Further, the ground electrodes 210 of both electrode pads may be substantially aligned along the central axis, along with the ground lines.", "It has been found that this arrangement may present certain advantages.", "For example, by essentially sharing the same ground trace, the width of the proximal tail may be only about one and a half times that of the intermediate tail, rather than being approximately twice as wide if each electrode pad had independent ground lines.", "Thus, the proximal tail 338, 438 may be narrower than two intermediate tails 328, 428 positioned side-by-side.", "FIG.", "11A illustrates an electrode assembly 340 with linear rows of positive electrodes 212 and ground electrodes 210, where substrate material, including a base layer 202, extends between the rows.", "FIG.", "11B illustrates a similar electrode assembly 440 with the substrate material cut out between the linear rows of electrodes 212, 210.The removal of substrate material between the rows of electrodes reduces the mass of the circuit that must be folded.", "When disposed on a balloon, the electrode assembly 440 may provide enhanced foldability as compared to electrode assembly 340 because lack of substrate between the linear rows of electrodes may allow for easier folding between the electrode rows, with the temperature sensor 226 being folded with the ground electrodes 210.This structure may allow the device to be inserted and withdrawn through a smaller sheath or catheter.", "However, even with the base layer 202 present between the rows of electrodes, as shown in FIG.", "11A, moving the temperature sensor 226 away from the center and onto a row of electrodes provides enhanced foldability over the prior art electrode assemblies shown in FIGS.", "2A and 2B.", "The electrode assemblies 340, 440 shown in FIGS.", "11A and 11B also show a temperature sensor 226 placed in line with and proximal of the most proximal ground electrode 210.This configuration provides the electrodes and temperature sensors in two linear rows, which may aid in folding the electrode assembly along a line between the rows of electrodes.", "In some embodiments, the temperature sensor 226 may be a sputtered thermocouple (for example, Type T configuration: Copper/Constantan).", "In the embodiment illustrated in FIGS.", "12A and 12B, the temperature sensor is a thermocouple 426 with a junction close to the middle electrode on the ground trace 210.The middle electrode may have less variation due to apposition of the balloon and may have better correlation or error to the prior art center position.", "In some embodiments, the thermocouple may include separate layers of copper and constantan.", "The thermocouple can be formed by a through hole between the two layers and may be filled with solder, which makes the through hole the thermocouple junction.", "As in FIGS.", "11A and 11B, FIG.", "12A shows an electrode assembly 440 with substrate or base layer 402 disposed between the ground trace 210 and the positive trace 212, while FIG.", "12B shows an electrode assembly 540 with the substrate removed between the rows of positive and negative electrodes.", "The thermocouple junction may be placed on or near a proximal ground electrode, as shown in FIGS.", "13A and 13B.", "The thermal junction may be made of copper and constantan (T-type), instead of gold and constantan.", "However, the junction is close to the copper layer so it can measure the exact temperature of the heating element.", "A thermocouple may generate a voltage differential at the junction of two dissimilar metals based upon the temperature at the junction, as is known in the art.", "In some embodiments, an isothermal junction may be formed at a proximal end of the electrode assembly 140, spaced apart from and thermally isolated from the electrode pad(s) and/or the plurality of electrodes.", "In some embodiments, the temperature sensor 226 may be formed as a discrete trace of electrodeposited copper within the conductive layer 204.In some embodiments, the distal end portion of the sensor trace 214, and in some cases the entire sensor trace 214 may be formed from, for example, constantan (i.e., copper-nickel alloy), nickel-chromium, or other suitable conductive material.", "FIG.", "13A shows another embodiment of electrode assembly 640 having parallel rows of ground electrodes 210 and positive electrodes 212 on a substrate or base layer 502.The temperature sensor 526 may be a thermocouple with a junction at the proximal end of the proximal-most ground electrode 210.FIG.", "13B shows a similar electrode assembly 740 with a portion of the base layer 502 removed between the rows of ground electrodes 210 and positive electrodes 212.Exemplary devices have a very uniform temperature profile on the balloon and inside tissue during RF delivery due to their balloon structure and bipolar energy delivery.", "FIG.", "14 is a cross-sectional view of a simplified model electrode assembly 840 with electrodes 822, conductive layer 804, and base layer or substrate 802.FIGS.", "15A-15C show thermal profiles of various surfaces at 30 seconds of heating.", "FIG.", "15A shows the surface of polyimide base layer 802, through section A-A in FIG.", "14.FIG.", "15B shows the interface between a copper conductive layer 804 and the polyimide base layer 802, through section B-B in FIG.", "14.FIG.", "15C shows the balloon outer diameter at section C-C in FIG.", "14.As can be seen when comparing FIGS.", "15A-15C, the temperature profile is essentially constant across the cross-section of the electrode assembly 840.The temperature at the center of the balloon 1501 is close to the temperature at the electrodes 1502.Because of this consistency, the temperature at the center of the balloon 1501 is also close to and well correlated with the temperature at the edge of the electrode assembly 1502.FIG.", "16 illustrates the temperature at the center of an electrode pair 1601 and at various distances from the center.", "As can be seen, the temperature is essentially constant from the center of the electrode pair to the edge of the row of electrodes.", "A temperature measurement near an electrode has been found to be suitable for temperature control instead of a center temperature measurement, while maintaining lesion consistency.", "In use, the ablation device 120 may be advanced through a blood vessel or body passageway to a position adjacent to a target tissue (e.g., within a renal artery), in some cases with the aid of a delivery sheath or catheter 14.In some embodiments, the target tissue may be one or more sympathetic nerves disposed about the blood vessel.", "In some embodiments, the control unit 110 may be operationally coupled to the ablation device 120, which may be inserted into a blood vessel or body passageway such that an expandable member 130 (having a plurality of electrode assemblies 300) may be placed adjacent to the target tissue where therapy is required.", "Placement of the ablation device 120 adjacent the target tissue where therapy is required may be performed according to conventional methods, (e.g., over a guidewire under fluoroscopic guidance).", "When suitably positioned, the expandable member 130 may be expanded from a collapsed delivery configuration to an expanded configuration, for example by pressurizing fluid from about 2-10 atm in the case of a balloon.", "This may place/urge the plurality of electrodes against the wall of the blood vessel.", "The plurality of active electrodes may be activated.", "Ablation energy may be transmitted from the plurality of active electrodes through the target tissue (where sympathetic nerves may be ablated, modulated, or otherwise impacted), and back through the plurality of ground electrodes, in a bipolar configuration, or back through the common ground electrode, in a monopolar configuration.", "Following treatment, the expandable member 130 may be collapsed to the collapsed delivery configuration for retraction into the guide sheath or catheter 14 and subsequent withdrawal from the blood vessel or body passageway.", "The materials that can be used for the various components of the ablation device 120 (and/or other devices disclosed herein) may include those commonly associated with medical devices.", "For simplicity purposes, the following discussion makes reference to the ablation device 120.However, this is not intended to limit the devices and methods described herein, as the discussion may be applied to other similar tubular members and/or expandable members and/or components of tubular members and/or expandable members disclosed herein.", "The ablation device 120 and the various components thereof may be made from a metal, metal alloy, polymer (some examples of which are disclosed below), a metal-polymer composite, ceramics, combinations thereof, and the like, or other suitable material.", "Some examples of suitable polymers may include polytetrafluoroethylene (PTFE), ethylene tetrafluoroethylene (ETFE), fluorinated ethylene propylene (FEP), polyoxymethylene (POM, for example, DELRIN® available from DuPont), polyether block ester, polyurethane (for example, Polyurethane 85A), polypropylene (PP), polyvinylchloride (PVC), polyether-ester (for example, ARNITEL® available from DSM Engineering Plastics), ether or ester based copolymers (for example, butylene/poly(alkylene ether) phthalate and/or other polyester elastomers such as HYTREL® available from DuPont), polyamide (for example, DURETHAN® available from Bayer or CRISTAMID® available from Elf Atochem), elastomeric polyamides, block polyamide/ethers, polyether block amide (PEBA, for example available under the trade name PEBAX®), ethylene vinyl acetate copolymers (EVA), silicones, polyethylene (PE), Marlex high-density polyethylene, Marlex low-density polyethylene, linear low density polyethylene (for example REXELL®), polyester, polybutylene terephthalate (PBT), polyethylene terephthalate (PET), polytrimethylene terephthalate, polyethylene naphthalate (PEN), polyetheretherketone (PEEK), polyimide (PI), polyetherimide (PEI), polyphenylene sulfide (PPS), polyphenylene oxide (PPO), poly paraphenylene terephthalamide (for example, KEVLAR®), polysulfone, nylon, nylon-12 (such as GRILAMID® available from EMS American Grilon), perfluoro(propyl vinyl ether) (PFA), ethylene vinyl alcohol, polyolefin, polystyrene, epoxy, polyvinylidene chloride (PVdC), poly(styrene-b-isobutylene-b-styrene) (for example, SIBS and/or SIBS 50A), polycarbonates, ionomers, biocompatible polymers, other suitable materials, or mixtures, combinations, copolymers thereof, polymer/metal composites, and the like.", "In some embodiments the sheath can be blended with a liquid crystal polymer (LCP).", "For example, the mixture can contain up to about 6 percent LCP.", "Some examples of suitable metals and metal alloys include stainless steel, such as 304V, 304 L, and 316 LV stainless steel; mild steel; nickel-titanium alloy such as linear-elastic and/or super-elastic nitinol; other nickel alloys such as nickel-chromium-molybdenum alloys (e.g., UNS: N06625 such as INCONEL® 625, UNS: N06022 such as HASTELLOY® C-22®, UNS: N10276 such as HASTELLOY® C276®, other HASTELLOY® alloys, and the like), nickel-copper alloys (e.g., UNS: N04400 such as MONEL® 400, NICKELVAC® 400, NICORROS® 400, and the like), nickel-cobalt-chromium-molybdenum alloys (e.g., UNS: R30035 such as MP35-N® and the like), nickel-molybdenum alloys (e.g., UNS: N10665 such as HASTELLOY® ALLOY B2®), other nickel-chromium alloys, other nickel-molybdenum alloys, other nickel-cobalt alloys, other nickel-iron alloys, other nickel-copper alloys, other nickel-tungsten or tungsten alloys, and the like; cobalt-chromium alloys; cobalt-chromium-molybdenum alloys (e.g., UNS: R30003 such as ELGILOY®, PHYNOX®, and the like); platinum enriched stainless steel; titanium; combinations thereof; and the like; or any other suitable material.", "As alluded to herein, within the family of commercially available nickel-titanium or nitinol alloys, is a category designated “linear elastic” or “non-super-elastic” which, although may be similar in chemistry to conventional shape memory and super elastic varieties, may exhibit distinct and useful mechanical properties.", "Linear elastic and/or non-super-elastic nitinol may be distinguished from super elastic nitinol in that the linear elastic and/or non-super-elastic nitinol does not display a substantial “superelastic plateau” or “flag region” in its stress/strain curve like super elastic nitinol does.", "Instead, in the linear elastic and/or non-super-elastic nitinol, as recoverable strain increases, the stress continues to increase in a substantially linear, or a somewhat, but not necessarily entirely linear relationship until plastic deformation begins or at least in a relationship that is more linear that the super elastic plateau and/or flag region that may be seen with super elastic nitinol.", "Thus, for the purposes of this disclosure linear elastic and/or non-super-elastic nitinol may also be termed “substantially” linear elastic and/or non-super-elastic nitinol.", "In some cases, linear elastic and/or non-super-elastic nitinol may also be distinguishable from super elastic nitinol in that linear elastic and/or non-super-elastic nitinol may accept up to about 2-5% strain while remaining substantially elastic (e.g., before plastically deforming) whereas super elastic nitinol may accept up to about 8% strain before plastically deforming.", "Both of these materials can be distinguished from other linear elastic materials such as stainless steel (that can also can be distinguished based on its composition), which may accept only about 0.2 to 0.44 percent strain before plastically deforming.", "In some embodiments, the linear elastic and/or non-super-elastic nickel-titanium alloy is an alloy that does not show any martensite/austenite phase changes that are detectable by differential scanning calorimetry (DSC) and dynamic metal thermal analysis (DMTA) analysis over a large temperature range.", "For example, in some embodiments, there may be no martensite/austenite phase changes detectable by DSC and DMTA analysis in the range of about −60 degrees Celsius (° C.) to about 120° C. in the linear elastic and/or non-super-elastic nickel-titanium alloy.", "The mechanical bending properties of such material may therefore be generally inert to the effect of temperature over this very broad range of temperature.", "In some embodiments, the mechanical bending properties of the linear elastic and/or non-super-elastic nickel-titanium alloy at ambient or room temperature are substantially the same as the mechanical properties at body temperature, for example, in that they do not display a super-elastic plateau and/or flag region.", "In other words, across a broad temperature range, the linear elastic and/or non-super-elastic nickel-titanium alloy maintains its linear elastic and/or non-super-elastic characteristics and/or properties.", "In some embodiments, the linear elastic and/or non-super-elastic nickel-titanium alloy may be in the range of about 50 to about 60 weight percent nickel, with the remainder being essentially titanium.", "In some embodiments, the composition is in the range of about 54 to about 57 weight percent nickel.", "One example of a suitable nickel-titanium alloy is FHP-NT alloy commercially available from Furukawa Techno Material Co. of Kanagawa, Japan.", "Some examples of nickel titanium alloys are disclosed in U.S. Pat.", "Nos.", "5,238,004 and 6,508,803, which are incorporated herein by reference.", "Other suitable materials may include ULTANIUM™ (available from Neo-Metrics) and GUM METAL™ (available from Toyota).", "In some other embodiments, a superelastic alloy, for example a superelastic nitinol can be used to achieve desired properties.", "In at least some embodiments, portions of the ablation device 120 may also be doped with, made of, or otherwise include a radiopaque material.", "Radiopaque materials are understood to be materials capable of producing a relatively bright image on a fluoroscopy screen or another imaging technique during a medical procedure.", "This relatively bright image aids the user of the ablation device 120 in determining its location.", "Some examples of radiopaque materials can include, but are not limited to, gold, platinum, palladium, tantalum, tungsten alloy, polymer material loaded with a radiopaque filler, and the like.", "Additionally, other radiopaque marker bands and/or coils may also be incorporated into the design of the ablation device 120 to achieve the same result.", "In some embodiments, a degree of Magnetic Resonance Imaging (MRI) compatibility may be imparted into the ablation device 120.For example, portions of device, may be made of a material that does not substantially distort the image and create substantial artifacts (i.e., gaps in the image).", "Certain ferromagnetic materials, for example, may not be suitable because they may create artifacts in an MRI image.", "In some of these and in other embodiments, portions of the ablation device 120 may also be made from a material that the MRI machine can image.", "Some materials that exhibit these characteristics include, for example, tungsten, cobalt-chromium-molybdenum alloys (e.g., UNS: R30003 such as ELGILOY®, PHYNOX®, and the like), nickel-cobalt-chromium-molybdenum alloys (e.g., UNS: R30035 such as MP35-N® and the like), nitinol, and the like, and others.", "U.S. patent application Ser.", "No.", "13/750,879, filed on Jan. 25, 2013, now U.S. Patent Publication No.", "US20130165926A1 is herein incorporated by reference.", "It should be understood that this disclosure is, in many respects, only illustrative.", "Changes may be made in details, particularly in matters of shape, size, and arrangement of steps without exceeding the scope of the disclosure.", "This may include, to the extent that it is appropriate, the use of any of the features of one example embodiment being used in other embodiments.", "The invention's scope is, of course, defined in the language in which the appended claims are expressed." ] ]
Patent_15874223
[ [ "SEMICONDUCTOR DEVICE", "In a transistor including an oxide semiconductor film, movement of hydrogen and nitrogen to the oxide semiconductor film is suppressed.", "Further, in a semiconductor device using a transistor including an oxide semiconductor film, a change in electrical characteristics is suppressed and reliability is improved.", "A transistor including an oxide semiconductor film and a nitride insulating film provided over the transistor are included, and an amount of hydrogen molecules released from the nitride insulating film by thermal desorption spectroscopy is less than 5×1021 molecules/cm3, preferably less than or equal to 3×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3, and an amount of ammonia molecules released from the nitride insulating film by thermal desorption spectroscopy is less than 1×1022 molecules/cm3, preferably less than or equal to 5×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3." ], [ "1.", "(canceled) 2.A method for manufacturing a semiconductor device comprising the steps of: forming a first gate electrode; forming a gate insulating film over the first gate electrode; forming an oxide semiconductor film over the gate insulating film, the oxide semiconductor film overlapping with the first gate electrode; forming a pair of electrodes in contact with the oxide semiconductor film; and forming a nitride insulating film over the oxide semiconductor film by a plasma CVD method using a source gas containing nitrogen and ammonia, wherein in the step of forming the nitride insulating film, a flow ratio of the nitrogen to the ammonia is greater than or equal to 5 and less than or equal to 50.3.The method for manufacturing a semiconductor device according to claim 2, wherein the flow ratio of the nitrogen to the ammonia is greater than or equal to 10 and less than or equal to 50.4.The method for manufacturing a semiconductor device according to claim 2, further comprising the step of: forming an oxide insulating film over the oxide semiconductor film before the step of forming the nitride insulating film, wherein the oxide insulating film is in contact with part of the oxide semiconductor film.", "5.The method for manufacturing a semiconductor device according to claim 2, wherein in the case where the nitride insulating film is analyzed by thermal desorption spectroscopy, hydrogen molecules less than 5×1021 molecules/cm3 and ammonia molecules less than 1×1022 molecules/cm3 are released.", "6.The method for manufacturing a semiconductor device according to claim 2, further comprising a step of: performing a heat treatment on the oxide semiconductor film in an atmosphere containing nitrogen and oxygen.", "7.The method for manufacturing a semiconductor device according to claim 2, wherein the source gas further contains a deposition gas containing silicon.", "8.The method for manufacturing a semiconductor device according to claim 2, further comprising the step of: forming a second gate electrode over the nitride insulating film, the second gate electrode overlapping with the first gate electrode.", "9.A method for manufacturing a semiconductor device comprising the steps of: forming an insulating film; forming an oxide semiconductor film over the insulating film; forming a pair of electrodes in contact with the oxide semiconductor film; forming a gate insulating film comprising a nitride insulating film over the oxide semiconductor film; and forming a gate electrode over the gate insulating film, wherein the nitride insulating film is formed by a plasma CVD method using a source gas containing nitrogen and ammonia, and wherein in the step of forming the nitride insulating film, a flow ratio of the nitrogen to the ammonia is greater than or equal to 5 and less than or equal to 50.10.The method for manufacturing a semiconductor device according to claim 9, wherein the insulating film comprises an oxide insulating film, and wherein oxygen is added to the oxide insulating film before the step of forming the oxide semiconductor film.", "11.The method for manufacturing a semiconductor device according to claim 9, wherein the flow ratio of the nitrogen to the ammonia is greater than or equal to 10 and less than or equal to 50.12.The method for manufacturing a semiconductor device according to claim 9, wherein the gate insulating film further comprises an oxide insulating film, and wherein the oxide insulating film is between the oxide semiconductor film and the nitride insulating film.", "13.The method for manufacturing a semiconductor device according to claim 9, wherein in the case where the nitride insulating film is analyzed by thermal desorption spectroscopy, hydrogen molecules less than 5×1021 molecules/cm3 and ammonia molecules less than 1×1022 molecules/cm3 are released.", "14.The method for manufacturing a semiconductor device according to claim 9, further comprising the step of: performing a heat treatment on the oxide semiconductor film in an atmosphere containing nitrogen and oxygen.", "15.The method for manufacturing a semiconductor device according to claim 9, wherein the source gas further contains a deposition gas containing silicon.", "16.A method for manufacturing a semiconductor device comprising the steps of: forming a first gate electrode; forming a gate insulating film comprising a first nitride insulating film over the first gate electrode; forming an oxide semiconductor film over the gate insulating film, the oxide semiconductor film overlapping with the first gate electrode; forming a pair of electrodes electrically connected to the oxide semiconductor film; and forming a second nitride insulating film over the oxide semiconductor film, wherein the first nitride insulating film and the second nitride insulating film are each formed by a plasma CVD method using a source gas containing nitrogen and ammonia, and wherein in each of the step of forming the first nitride insulating film and the step of forming the second nitride insulating film, a flow ratio of the nitrogen to the ammonia is greater than or equal to 5 and less than or equal to 50.17.The method for manufacturing a semiconductor device according to claim 16, wherein the flow ratio of the nitrogen to the ammonia is greater than or equal to 10 and less than or equal to 50.18.The method for manufacturing a semiconductor device according to claim 16, further comprising the step of: forming an oxide insulating film over the oxide semiconductor film before the step of forming the second nitride insulating film, wherein the oxide insulating film is in contact with part of the oxide semiconductor film.", "19.The method for manufacturing a semiconductor device according to claim 16, wherein in the case where each of the first nitride insulating film and the second nitride insulating film are analyzed by thermal desorption spectroscopy, hydrogen molecules less than 5×1021 molecules/cm3 and ammonia molecules less than 1×1022 molecules/cm3 are released.", "20.The method for manufacturing a semiconductor device according to claim 16, further comprising a step of: performing a heat treatment on the oxide semiconductor film in an atmosphere containing nitrogen and oxygen.", "21.The method for manufacturing a semiconductor device according to claim 16, wherein the source gas further contains a deposition gas containing silicon.", "22.The method for manufacturing a semiconductor device according to claim 16, further comprising the step of: forming a second gate electrode over the second nitride insulating film, the second gate electrode overlapping with the first gate electrode." ], [ "<SOH> BACKGROUND ART <EOH>Transistors used for most flat panel displays typified by a liquid crystal display device and a light-emitting display device are formed using silicon semiconductors such as amorphous silicon, single crystal silicon, and polycrystalline silicon provided over glass substrates.", "Further, transistors formed using the silicon semiconductors are used in integrated circuits (ICs) and the like.", "In recent years, a technique in which, instead of a silicon semiconductor, a metal oxide exhibiting semiconductor characteristics is used for transistors has attracted attention.", "Note that in this specification, a metal oxide exhibiting semiconductor characteristics is referred to as an oxide semiconductor.", "For example, a technique is disclosed in which a transistor is manufactured using zinc oxide or an In—Ga—Zn-based oxide as an oxide semiconductor and the transistor is used as a switching element or the like of a pixel of a display device (see Patent Documents 1 and 2).", "Meanwhile, it has been pointed out that hydrogen is a source for supplying carriers particularly in an oxide semiconductor.", "Therefore, some measures need to be taken to prevent hydrogen from entering the oxide semiconductor at the time of forming the oxide semiconductor.", "Further, variation in a threshold voltage is suppressed by reducing the amount of hydrogen contained in the oxide semiconductor film or a gate insulating film in contact with the oxide semiconductor (see Patent Document 3).", "Further, water is a source for supplying hydrogen.", "Therefore, by providing a silicon nitride film having a property of blocking water over a transistor including an oxide semiconductor film, entry of water from the outside to the oxide semiconductor film can be prevented." ], [ "<SOH> BRIEF DESCRIPTION OF DRAWINGS <EOH>In the accompanying drawings: FIGS.", "1A and 1B are diagrams illustrating one embodiment of a transistor; FIGS.", "2A to 2D are cross-sectional views illustrating one embodiment of a method for manufacturing a transistor; FIGS.", "3A and 3B are diagrams illustrating one embodiment of a transistor; FIGS.", "4A to 4D are cross-sectional views illustrating one embodiment of a method for manufacturing a transistor; FIG.", "5 is a cross-sectional view illustrating one embodiment of a transistor; FIGS.", "6A and 6B are diagrams illustrating one embodiment of a transistor; FIGS.", "7A and 7B are diagrams illustrating one embodiment of a transistor; FIGS.", "8A to 8C are top views illustrating one embodiment of a display device; FIGS.", "9A and 9B are cross-sectional views illustrating one embodiment of a display device; FIG.", "10 is a cross-sectional view illustrating one embodiment of a display device; FIGS.", "11A to 11C are cross-sectional views and a top view illustrating one embodiment of a display device; FIGS.", "12A and 12B illustrate one embodiment of a semiconductor device; FIGS.", "13A to 13C each illustrate an electronic device; FIGS.", "14A to 14C illustrate an electronic device; FIGS.", "15A and 15B each illustrate a structure of a sample; FIGS.", "16A to 16C show results of TDS analysis; FIGS.", "17A and 17B show results of TDS analysis; FIGS.", "18A and 18B show results of TDS analysis; FIGS.", "19A and 19B show results of TDS analysis; FIGS.", "20A to 20C each show Vg-Id characteristics of a transistor; FIGS.", "21A to 21C each show Vg-Id characteristics of a transistor; FIGS.", "22A to 22C each show Vg-Id characteristics of a transistor; and FIG.", "23 shows an amount of released hydrogen molecules and an amount of released ammonia molecules from a silicon nitride film, and Vg-Id characteristics of a transistor.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "TECHNICAL FIELD The present invention relates to a semiconductor device including a field-effect transistor and a method for manufacturing the semiconductor device.", "BACKGROUND ART Transistors used for most flat panel displays typified by a liquid crystal display device and a light-emitting display device are formed using silicon semiconductors such as amorphous silicon, single crystal silicon, and polycrystalline silicon provided over glass substrates.", "Further, transistors formed using the silicon semiconductors are used in integrated circuits (ICs) and the like.", "In recent years, a technique in which, instead of a silicon semiconductor, a metal oxide exhibiting semiconductor characteristics is used for transistors has attracted attention.", "Note that in this specification, a metal oxide exhibiting semiconductor characteristics is referred to as an oxide semiconductor.", "For example, a technique is disclosed in which a transistor is manufactured using zinc oxide or an In—Ga—Zn-based oxide as an oxide semiconductor and the transistor is used as a switching element or the like of a pixel of a display device (see Patent Documents 1 and 2).", "Meanwhile, it has been pointed out that hydrogen is a source for supplying carriers particularly in an oxide semiconductor.", "Therefore, some measures need to be taken to prevent hydrogen from entering the oxide semiconductor at the time of forming the oxide semiconductor.", "Further, variation in a threshold voltage is suppressed by reducing the amount of hydrogen contained in the oxide semiconductor film or a gate insulating film in contact with the oxide semiconductor (see Patent Document 3).", "Further, water is a source for supplying hydrogen.", "Therefore, by providing a silicon nitride film having a property of blocking water over a transistor including an oxide semiconductor film, entry of water from the outside to the oxide semiconductor film can be prevented.", "REFERENCE Patent Document [Patent Document 1] Japanese Published Patent Application No.", "2007-123861 [Patent Document 2] Japanese Published Patent Application No.", "2007-096055 [Patent Document 3] Japanese Published Patent Application No.", "2009-224479 DISCLOSURE OF INVENTION However, nitrogen becomes a source for supplying carriers in a similar manner to hydrogen.", "Thus, when nitrogen contained in a silicon nitride film enters an oxide semiconductor film, a change in electrical characteristics in a transistor including an oxide semiconductor film, typically, a shift of the threshold voltage in the negative direction occurs.", "Further, there is a problem in that electrical characteristics vary among transistors.", "Thus, an object of one embodiment of the present invention is to suppress movement of hydrogen and nitrogen to an oxide semiconductor film in a transistor including an oxide semiconductor film.", "It is another object of one embodiment of the present invention to suppress a change in electrical characteristics and to improve reliability in a semiconductor device using a transistor including an oxide semiconductor.", "One embodiment of the present invention includes a transistor including an oxide semiconductor film and a nitride insulating film provided over the transistor, and an amount of hydrogen molecules released from the nitride insulating film by heating is smaller than 5×1021 molecules/cm3, preferably smaller than or equal to 3×1021 molecules/cm3, more preferably smaller than or equal to 1×1021 molecules/cm3, and an amount of ammonia molecules released from the nitride insulating film by heating is smaller than 1×1022 molecules/cm3, preferably smaller than or equal to 5×1021 molecules/cm3, more preferably smaller than or equal to 1×1021 molecules/cm3.Another embodiment of the present invention includes a gate electrode, an oxide semiconductor film overlapping with a part of the gate electrode with a gate insulating film provided therebetween, a pair of electrodes in contact with the oxide semiconductor film, and a nitride insulating film provided over the oxide semiconductor film.", "An amount of hydrogen molecules released from the nitride insulating film by heating is smaller than 5×1021 molecules/cm3, preferably smaller than or equal to 3×1021 molecules/cm3, more preferably smaller than or equal to 1×1021 molecules/cm3, and an amount of ammonia molecules released from the nitride insulating film by heating is smaller than 1×1022 molecules/cm3, preferably smaller than or equal to 5×1021 molecules/cm3, more preferably smaller than or equal to 1×1021 molecules/cm3.Another embodiment of the present invention includes a nitride insulating film as a gate insulating film in a transistor including an oxide semiconductor film.", "An amount of hydrogen molecules released from the nitride insulating film by heating is smaller than 5×1021 molecules/cm3, preferably smaller than or equal to 3×1021 molecules/cm3, more preferably smaller than or equal to 1×1021 molecules/cm3, and an amount of ammonia molecules released from the nitride insulating film by heating is smaller than 1×1022 molecules/cm3, preferably smaller than or equal to 5×1021 molecules/cm3, more preferably smaller than or equal to 1×1021 molecules/cm3.Another embodiment of the present invention includes an oxide semiconductor film, a pair of electrodes in contact with the oxide semiconductor film, a gate insulating film provided over at least the oxide semiconductor film, and a gate electrode overlapping with a part of the oxide semiconductor film with the gate insulating film provided therebetween.", "The gate insulating film includes a nitride insulating film.", "An amount of hydrogen molecules released from the nitride insulating film by heating is smaller than 5×1021 molecules/cm3, preferably smaller than or equal to 3×1021 molecules/cm3, more preferably smaller than or equal to 1×1021 molecules/cm3, and an amount of ammonia molecules released from the nitride insulating film by heating is smaller than 1×1022 molecules/cm3, preferably smaller than or equal to 5×1021 molecules/cm3, more preferably smaller than or equal to 1×1021 molecules/cm3.A nitride insulating film which releases hydrogen molecules less than 5×1021 molecules/cm3, preferably less than or equal to 3×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3, and ammonia molecules less than 1×1022 molecules/cm3, preferably less than or equal to 5×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3 by heating is provided over a transistor including an oxide semiconductor film, whereby the amount of hydrogen and nitrogen which are moved from the nitride insulating film to the oxide semiconductor film can be reduced.", "Further, entry of hydrogen contained in water to the oxide semiconductor film from the outside can be suppressed.", "Further, as a gate insulating film of a transistor including an oxide semiconductor film, a nitride insulating film which releases hydrogen molecules less than 5×1021 molecules/cm3, preferably less than or equal to 3×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3, and ammonia molecules less than 1×1022 molecules/cm3, preferably less than or equal to 5×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3 by heating is provided, whereby the amount of hydrogen and nitrogen which are moved from the nitride insulating film to the oxide semiconductor film can be reduced.", "Further, entry of hydrogen contained in water to the oxide semiconductor film from the outside can be suppressed.", "With one embodiment of the present invention, a change in electrical characteristics of a transistor including an oxide semiconductor film is suppressed and reliability can be improved.", "BRIEF DESCRIPTION OF DRAWINGS In the accompanying drawings: FIGS.", "1A and 1B are diagrams illustrating one embodiment of a transistor; FIGS.", "2A to 2D are cross-sectional views illustrating one embodiment of a method for manufacturing a transistor; FIGS.", "3A and 3B are diagrams illustrating one embodiment of a transistor; FIGS.", "4A to 4D are cross-sectional views illustrating one embodiment of a method for manufacturing a transistor; FIG.", "5 is a cross-sectional view illustrating one embodiment of a transistor; FIGS.", "6A and 6B are diagrams illustrating one embodiment of a transistor; FIGS.", "7A and 7B are diagrams illustrating one embodiment of a transistor; FIGS.", "8A to 8C are top views illustrating one embodiment of a display device; FIGS.", "9A and 9B are cross-sectional views illustrating one embodiment of a display device; FIG.", "10 is a cross-sectional view illustrating one embodiment of a display device; FIGS.", "11A to 11C are cross-sectional views and a top view illustrating one embodiment of a display device; FIGS.", "12A and 12B illustrate one embodiment of a semiconductor device; FIGS.", "13A to 13C each illustrate an electronic device; FIGS.", "14A to 14C illustrate an electronic device; FIGS.", "15A and 15B each illustrate a structure of a sample; FIGS.", "16A to 16C show results of TDS analysis; FIGS.", "17A and 17B show results of TDS analysis; FIGS.", "18A and 18B show results of TDS analysis; FIGS.", "19A and 19B show results of TDS analysis; FIGS.", "20A to 20C each show Vg-Id characteristics of a transistor; FIGS.", "21A to 21C each show Vg-Id characteristics of a transistor; FIGS.", "22A to 22C each show Vg-Id characteristics of a transistor; and FIG.", "23 shows an amount of released hydrogen molecules and an amount of released ammonia molecules from a silicon nitride film, and Vg-Id characteristics of a transistor.", "BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.", "However, the present invention is not limited to the following description and it is easily understood by those skilled in the art that the mode and details can be variously changed without departing from the scope and spirit of the present invention.", "Therefore, the present invention should not be construed as being limited to the description in the following embodiments and examples.", "In addition, in the following embodiments and examples, the same portions or portions having similar functions are denoted by the same reference numerals or the same hatching patterns in different drawings, and description thereof will not be repeated.", "Note that in each drawing described in this specification, the size, the film thickness, or the region of each component is exaggerated for clarity in some cases.", "Therefore, embodiments of the present invention are not limited to such scales.", "Note that terms such as “first”, “second”, and “third” in this specification are used in order to avoid confusion among components, and the terms do not limit the components numerically.", "Therefore, for example, the term “first” can be replaced with the term “second”, “third”, or the like as appropriate.", "Functions of a “source” and a “drain” are sometimes replaced with each other when the direction of current flow is changed in circuit operation, for example.", "Therefore, the terms “source” and “drain” can be used to denote the drain and the source, respectively, in this specification.", "Note that a voltage refers to a difference between potentials of two points, and a potential refers to electrostatic energy (electric potential energy) of a unit charge at a given point in an electrostatic field.", "Note that in general, a difference between potential of one point and reference potential (e.g., ground potential) is merely called potential or voltage, and potential and voltage are used as synonymous words in many cases.", "Thus, in this specification, a potential may be rephrased as a voltage and a voltage may be rephrased as a potential unless otherwise specified.", "Note that a transistor including an oxide semiconductor film is an n-channel transistor; therefore, in this specification, a transistor which can be regarded as having no drain current flowing therein when a gate voltage is 0 V is defined as a transistor having normally-off characteristics.", "In contrast, a transistor which can be regarded as having a drain current flowing therein when a gate voltage is 0 V is defined as a transistor having normally-on characteristics.", "Embodiment 1 In this embodiment, a semiconductor device of one embodiment of the present invention and a method for manufacturing the semiconductor device is described with reference to drawings.", "FIGS.", "1A and 1B are a top view and a cross-sectional view of a transistor 1 included in a semiconductor device.", "FIG.", "1A is a top view of the transistor 1 and FIG.", "1B is a cross-sectional view taken along dashed-dotted line A-B in FIG.", "1A.", "Note that in FIG.", "1A, a substrate 11, some components of the transistor 1 (e.g., a gate insulating film 18), an insulating film 23, a nitride insulating film 25, and the like are omitted for simplicity.", "The transistor 1 illustrated in FIGS.", "1A and 1B includes a gate electrode 15 provided over the substrate 11, the gate insulating film 18 formed over the substrate 11 and the gate electrode 15, an oxide semiconductor film 19 overlapping with the gate electrode 15 with the gate insulating film 18 provided therebetween, and a pair of electrodes 21 in contact with the oxide semiconductor film 19.A protective film 26 including the insulating film 23 and the nitride insulating film 25 is formed over the gate insulating film 18, the oxide semiconductor film 19, and the pair of electrodes 21.The nitride insulating film 25 provided over the transistor 1 in this embodiment releases hydrogen molecules less than 5×1021 molecules/cm3, preferably less than or equal to 3×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3, and ammonia molecules less than 1×1022 molecules/cm3, preferably less than or equal to 5×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3 by thermal desorption spectroscopy (TDS).", "The number of hydrogen molecules and the number of ammonia molecules which are sources for supplying nitrogen, which are released from the nitride insulating film 25, are small; thus, the amount of hydrogen and nitrogen which are moved to the oxide semiconductor film 19 in the transistor 1 is small.", "Hydrogen contained in the oxide semiconductor film 19 reacts with oxygen bonded to a metal atom to produce water, and a defect is formed in a lattice from which oxygen is released (or a portion from which oxygen is released).", "In addition, part of hydrogen reacts with oxygen, which causes generation of electrons serving as carriers.", "Further, nitrogen contained in the oxide semiconductor film 19 reacts with a metal element or oxygen, which causes generation of electrons serving as carriers.", "As a result, a transistor including the oxide semiconductor film 19 tends to be normally on.", "Therefore, hydrogen and nitrogen in the oxide semiconductor film 19 are reduced as much as possible, whereby a shift of the threshold voltage in the negative direction can be suppressed and variation in electrical characteristics can be reduced.", "Further, leakage current between a source and a drain of the transistor, typically off-state current, can be reduced.", "A nitride insulating film which releases hydrogen molecules less than 5×1021 molecules/cm3, preferably less than or equal to 3×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3, and ammonia molecules less than 1×1022 molecules/cm3, preferably less than or equal to 5×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3 by thermal desorption spectroscopy is provided over the transistor 1, whereby the amount of hydrogen and ammonia which are moved from the nitride insulating film to the oxide semiconductor film 19 can be small and concentration of hydrogen and nitrogen in the oxide semiconductor film 19 can be reduced.", "Further, the nitride insulating film 25 is provided over the transistor 1; therefore, entry of water from the outside to the oxide semiconductor film 19 can be suppressed.", "In other words, entry of hydrogen contained in water to the oxide semiconductor film 19 can be suppressed.", "As a result, a shift of the threshold voltage in the negative direction can be suppressed and variation in electrical characteristics can be reduced.", "Further, leakage current between a source and a drain of the transistor, typically off-state current, can be reduced.", "As the nitride insulating film 25, silicon nitride, silicon nitride oxide, aluminum nitride, aluminum nitride oxide, or the like with a thickness greater than or equal to 50 nm and less than or equal to 200 nm can be used.", "Note that in this specification, a “silicon oxynitride film” refers to a film that contains more oxygen than nitrogen, and a “silicon nitride oxide film” refers to a film that contains more nitrogen than oxygen.", "Further, an “aluminum oxynitride film” refers to a film that contains more oxygen than nitrogen, and an “aluminum nitride oxide film” refers to a film that contains more nitrogen than oxygen.", "Here, a method to measure the number of released hydrogen molecules and released ammonia molecules using thermal desorption spectroscopy (hereinafter, referred to as TDS analysis) is described below.", "The amount of released gas in the TDS analysis is proportional to an integral value of spectrum.", "Therefore, the amount of released gas can be calculated from the ratio between the integral value of a spectrum of an insulating film and the reference value of a standard sample.", "The reference value of a standard sample refers to the ratio of the density of a predetermined atom contained in a sample to the integral value of a spectrum.", "For example, the number of the released hydrogen molecules (NH2) from an insulating film can be calculated according to Formula 1 using the TDS analysis results of a silicon wafer containing hydrogen at a predetermined density, which is the standard sample, and the TDS analysis results of the insulating film.", "Here, all spectra having a mass number of 2 which are obtained by the TDS analysis are assumed to originate from an hydrogen molecule.", "Further, an isotope of a hydrogen atom having a mass number other than 1 is not taken into consideration because the proportion of such a molecule in the natural world is minimal [ FORMULA   1 ]  N H   2 = N H   2  ( S ) S H   2  ( S ) × S H   2 × α ( 1 ) NH2 is the number of the released hydrogen molecules.", "NH2(S) is the value obtained by conversion of the number of hydrogen molecules desorbed from the standard sample into densities.", "SH2(S) is the integral value of a spectrum when the standard sample is subjected to TDS analysis.", "Here, the reference value of the standard sample is set to NH2(S)/SH2(S).", "SH2 is the integral value of a spectrum when the insulating film is subjected to TDS analysis.", "α is a coefficient affecting the intensity of the spectrum in the TDS analysis.", "Refer to Japanese Published Patent Application No.", "H6-275697 for details of Formula 1.Note that the number of released hydrogen molecules from the above insulating film is measured with a thermal desorption spectroscopy apparatus produced by ESCO Ltd., EMD-WA1000S/W using a silicon wafer containing hydrogen atoms at 1×1016 atoms/cm3 as the standard sample.", "Further, in Formula 1, an integral value of spectrum when the number of released ammonia molecules from an insulating film is measured by the TDS analysis is substituted into SH2, whereby the number of released ammonia molecules can be obtained.", "Other details of the transistor 1 are described below.", "There is no particular limitation on the property of a material and the like of the substrate 11 as long as the material has heat resistance enough to withstand at least later heat treatment.", "For example, a glass substrate, a ceramic substrate, a quartz substrate, a sapphire substrate, or the like may be used as the substrate 11.Alternatively, a single crystal semiconductor substrate or a polycrystalline semiconductor substrate made of silicon, silicon carbide, or the like, a compound semiconductor substrate made of silicon germanium or the like, an SOI (silicon on insulator) substrate, or the like may be used as the substrate 11.Furthermore, any of these substrates further provided with a semiconductor element may be used as the substrate 11.Still alternatively, a flexible substrate may be used as the substrate 11, and the transistor 1 may be provided directly on the flexible substrate.", "Alternatively, a separation layer may be provided between the substrate 11 and the transistor 1.The separation layer can be used when part or the whole of a semiconductor device formed over the separation layer is separated from the substrate 11 and transferred onto another substrate.", "In such a case, the transistor 1 can move to a substrate having low heat resistance or a flexible substrate as well.", "The base insulating film may be provided between the substrate 11 and the gate electrode 15.As the base insulating film, a silicon oxide film, a silicon oxynitride film, a silicon nitride film, a silicon nitride oxide film, a gallium oxide film, a hafnium oxide film, an yttrium oxide film, an aluminum oxide film, an aluminum oxynitride film, and the like can be given as examples.", "Note that when a silicon nitride film, a gallium oxide film, a hafnium oxide film, an yttrium oxide film, an aluminum oxide film, or the like is used as the base insulating film, it is possible to suppress diffusion of impurities, typically, an alkali metal, water, hydrogen, and the like, into the oxide semiconductor film 19 from the substrate 11.The gate electrode 15 can be formed using a metal element selected from aluminum, chromium, copper, tantalum, titanium, molybdenum, and tungsten; an alloy containing any of these metal elements as a component; an alloy containing these metal elements in combination; or the like.", "Further, one or more metal elements selected from manganese and zirconium may be used.", "Further, the gate electrode 15 may have a single-layer structure or a stacked-layer structure of two or more layers.", "A single-layer structure of an aluminum film containing silicon; a two-layer structure in which a titanium film is stacked over an aluminum film; a two-layer structure in which a titanium film is stacked over a titanium nitride film; a two-layer structure in which a tungsten film is stacked over a titanium nitride film; a two-layer structure in which a tungsten film is stacked over a tantalum nitride film or a tungsten nitride film; and a three-layer structure in which a titanium film, an aluminum film, and a titanium film are stacked in this order can be given as examples.", "Alternatively, a film, an alloy film, or a nitride film which contains aluminum and one or more elements selected from titanium, tantalum, tungsten, molybdenum, chromium, neodymium, and scandium may be used.", "The gate electrode 15 can also be formed using a light-transmitting conductive material such as indium tin oxide, indium oxide containing tungsten oxide, indium zinc oxide containing tungsten oxide, indium oxide containing titanium oxide, indium tin oxide containing titanium oxide, indium zinc oxide, or indium tin oxide including silicon oxide.", "It is also possible to have a stacked-layer structure formed using the above light-transmitting conductive material and the above metal element.", "Further, an In—Ga—Zn-based oxynitride semiconductor film, an In—Sn-based oxynitride semiconductor film, an In—Ga-based oxynitride semiconductor film, an In—Zn-based oxynitride semiconductor film, a Sn-based oxynitride semiconductor film, an In-based oxynitride semiconductor film, a metal nitride film (such as an InN film or a ZnN film), or the like may be provided between the gate electrode 15 and the gate insulating film 18.These films each have a work function higher than or equal to 5 eV, preferably higher than or equal to 5.5 eV, which is higher than the electron affinity of an oxide semiconductor; thus, the threshold voltage of a transistor including the oxide semiconductor can be shifted in the positive direction.", "Accordingly, a switching element having what is called normally-off characteristics can be obtained.", "For example, in the case of using an In—Ga—Zn-based oxynitride semiconductor film, an In—Ga—Zn-based oxynitride semiconductor film having a higher nitrogen concentration than at least the oxide semiconductor film 19, specifically, an In—Ga—Zn-based oxynitride semiconductor film having a nitrogen concentration higher than or equal to 7 at.", "%, is used.", "The gate insulating film 18 can be formed to have a single-layer structure or a stacked-layer structure using, for example, one or more of a silicon oxide film, a silicon oxynitride film, a silicon nitride oxide film, a silicon nitride film, an aluminum oxide film, a hafnium oxide film, a gallium oxide film, and a Ga—Zn-based metal oxide film.", "Note that in order to improve the characteristics of the interface between the gate insulating film 18 and the oxide semiconductor film 19, a region in the gate insulating film 18 which is in contact with at least the oxide semiconductor film 19 is preferably formed using an oxide insulating film.", "It is possible to prevent outward diffusion of oxygen from the oxide semiconductor film 19 and entry of hydrogen, water, or the like into the oxide semiconductor film 19 from the outside by providing an insulating film having a blocking effect against oxygen, hydrogen, water, and the like for the gate insulating film 18.As for the insulating film having a blocking effect against oxygen, hydrogen, water, and the like, an aluminum oxide film, an aluminum oxynitride film, a gallium oxide film, a gallium oxynitride film, an yttrium oxide film, an yttrium oxynitride film, a hafnium oxide film, and a hafnium oxynitride film can be given as examples.", "Further, the gate insulating film 18 has a stacked structure in which a first silicon nitride film is formed using a silicon nitride film having fewer defects, a second silicon nitride film using a silicon nitride film which releases the small number of hydrogen molecules and ammonia molecules as the nitride insulating film 25 is formed over the first silicon nitride film, and an oxide insulating film is formed over the second silicon nitride film, whereby the gate insulating film 18 can be formed using a gate insulating film which has fewer defects and releases the small number of hydrogen molecules and ammonia molecules.", "As a result, movement of hydrogen and nitrogen contained in the gate insulating film 18 to the oxide semiconductor film 19 can be suppressed.", "By using a silicon nitride film as the gate insulating film 18, the following effect can be obtained.", "The silicon nitride film has a higher relative permittivity than a silicon oxide film and needs a larger thickness for an equivalent capacitance.", "Thus, the physical thickness of the gate insulating film can be increased.", "This makes it possible to suppress a decrease in withstand voltage of the transistor 1 and furthermore improve the withstand voltage, thereby suppressing electrostatic discharge damage to a semiconductor device.", "Further, in the case where copper is used for the gate electrode 15 and a silicon nitride film is used as the gate insulating film 18 in contact with the gate electrode 15, as the gate insulating film 18, a silicon nitride film releasing ammonia molecules by heating, which are reduced as much as possible, is preferably used.", "Thus, as the silicon nitride film, a silicon nitride film which can be used as the nitride insulating film 25 can be used.", "As a result, reaction between copper and ammonia molecules can be suppressed.", "In the case where the trap level (also referred to as interface level) is present at the interface between an oxide semiconductor film and a gate insulating film or in the gate insulating film in a transistor using an oxide semiconductor, a shift of the threshold voltage of the transistor, typically, a shift of the threshold voltage in the negative direction, and an increase in the subthreshold swing (S value) showing a gate voltage needed for changing the drain current by one digit when the transistor is turned on are caused.", "As a result, there is a problem in that electrical characteristics vary among transistors.", "Therefore, by using a silicon nitride film having fewer defects is used as a gate insulating film, a shift of the threshold voltage in the negative direction and variation in electrical characteristics of the transistor can be reduced.", "The gate insulating film 18 may be formed using a high-k material such as hafnium silicate (HfSiOx), hafnium silicate to which nitrogen is added (HfSixOyNz), hafnium aluminate to which nitrogen is added (HfAlxOyNz), hafnium oxide, or yttrium oxide, so that gate leakage current of the transistor can be reduced.", "The thickness of the gate insulating film 18 is preferably greater than or equal to 5 nm and less than or equal to 400 nm, more preferably greater than or equal to 10 nm and less than or equal to 300 nm, still more preferably greater than or equal to 50 nm and less than or equal to 250 nm.", "The oxide semiconductor film 19 preferably contains at least indium (In) or zinc (Zn).", "Alternatively, the oxide semiconductor film 19 preferably contains both In and Zn.", "In order to reduce variation in electrical characteristics of the transistors including the oxide semiconductor film 19, the oxide semiconductor film 19 preferably contains one or more of stabilizers in addition to In or Zn.", "As for stabilizers, gallium (Ga), tin (Sn), hafnium (Hf), aluminum (Al), zirconium (Zr), and the like can be given.", "As another stabilizer, lanthanoids such as lanthanum (La), cerium (Ce), praseodymium (Pr), neodymium (Nd), samarium (Sm), europium (Eu), gadolinium (Gd), terbium (Tb), dysprosium (Dy), holmium (Ho), erbium (Er), thulium (Tm), ytterbium (Yb), lutetium (Lu), and the like can be given.", "As the oxide semiconductor, for example, the following can be used: indium oxide, tin oxide; zinc oxide; a two-component metal oxide such as an In—Zn-based metal oxide, a Sn—Zn-based metal oxide, an Al—Zn-based metal oxide, a Zn—Mg-based metal oxide, a Sn—Mg-based metal oxide, an In—Mg-based metal oxide, an In—Ga-based metal oxide, or an In—W-based metal oxide; a three-component metal oxide such as an In—Ga—Zn-based metal oxide (also referred to as an IGZO), an In—Al—Zn-based metal oxide, an In—Sn—Zn-based metal oxide, a Sn—Ga—Zn-based metal oxide, an Al—Ga—Zn-based metal oxide, a Sn—Al—Zn-based metal oxide, an In—Hf—Zn-based metal oxide, an In—La—Zn-based metal oxide, an In—Ce—Zn-based metal oxide, an In—Pr—Zn-based metal oxide, an In—Nd—Zn-based metal oxide, an In—Sm—Zn-based metal oxide, an In—Eu—Zn-based metal oxide, an In—Gd—Zn-based metal oxide, an In—Tb—Zn-based metal oxide, an In—Dy—Zn-based metal oxide, an In—Ho—Zn-based metal oxide, an In—Er—Zn-based metal oxide, an In—Tm—Zn-based metal oxide, an In—Yb—Zn-based metal oxide, or an In—Lu—Zn-based metal oxide; or a four-component metal oxide such as an In—Sn—Ga—Zn-based metal oxide, an In—Hf—Ga—Zn-based metal oxide, an In—Al—Ga—Zn-based metal oxide, an In—Sn—Al—Zn-based metal oxide, an In—Sn—Hf—Zn-based metal oxide, or an In—Hf—Al—Zn-based metal oxide.", "Note that, for example, an In—Ga—Zn-based metal oxide means an oxide containing In, Ga, and Zn as its main components and there is no particular limitation on the ratio of In, Ga, and Zn.", "The In—Ga—Zn-based metal oxide may contain a metal element other than In, Ga, and Zn.", "Alternatively, a material represented by InMO3(ZnO)m (m>0 is satisfied, and m is not an integer) may be used as the oxide semiconductor.", "Note that M represents one or more metal elements selected from Ga, Fe, Mn, and Co. Alternatively, as the oxide semiconductor, a material represented by In2SnO5(ZnO)n (n>0 is satisfied, n is an integer) may be used.", "For example, it is possible to use an In—Ga—Zn-based metal oxide containing In, Ga, and Zn at an atomic ratio of 1:1:1 (=⅓:⅓:⅓), 2:2:1 (=⅖:⅖:⅕), or 3:1:2 (=½:⅙:⅓), or any of oxides whose composition is in the neighborhood of the above compositions.", "Alternatively, an In—Sn—Zn-based metal oxide containing In, Sn, and Zn at an atomic ratio of 1:1:1 (=⅓:⅓:⅓), 2:1:3 (=⅓:⅙:½), or 2:1:5 (=¼:⅛:⅝) may be used.", "Note that a proportion of each atom in the atomic ratio of the metal oxide varies within a range of ±20% as an error.", "However, the composition is not limited to those described above, and a material having the appropriate composition may be used depending on needed semiconductor characteristics and electrical characteristics (e.g., field-effect mobility, threshold voltage, and variation).", "In order to obtain needed semiconductor characteristics, it is preferable that the carrier density, the impurity concentration, the defect density, the atomic ratio of a metal element and oxygen, the interatomic distance, the density, and the like be set to be appropriate.", "For example, a high mobility can be obtained relatively easily in the case where the In—Sn—Zn-based metal oxide is used.", "However, the mobility can be increased by reducing the defect density in the bulk also in the case where the In—Ga—Zn-based metal oxide is used.", "Note that the energy gap of a metal oxide that can form the oxide semiconductor film 19 is 2 eV or more, preferably 2.5 eV or more, further preferably 3 eV or more.", "In this manner, the off-state current of a transistor can be reduced by using an oxide semiconductor having a wide energy gap.", "Note that the oxide semiconductor film 19 may have an amorphous structure, a single crystal structure, or a polycrystalline structure.", "As the oxide semiconductor film 19, a c-axis aligned crystalline oxide semiconductor film (also referred to as a CAAC-OS film) having crystal parts may be used.", "The CAAC-OS film is one of oxide semiconductor films including a plurality of crystal parts, and most of each crystal part fits inside a cube whose one side is less than 100 nm.", "Thus, there is a case where a crystal part included in the CAAC-OS film fits a cube whose one side is less than 10 nm, less than 5 nm, or less than 3 nm.", "The density of defect states of the CAAC-OS film is lower than that of the microcrystalline oxide semiconductor film.", "The CAAC-OS film is described in detail below.", "In a transmission electron microscope (TEM) image of the CAAC-OS film, a boundary between crystal parts, that is, a grain boundary is not clearly observed.", "Thus, in the CAAC-OS film, a reduction in electron mobility due to the grain boundary is less likely to occur.", "According to the TEM image of the CAAC-OS film observed in a direction substantially parallel to a sample surface (cross-sectional TEM image), metal atoms are arranged in a layered manner in the crystal parts.", "Each metal atom layer has a morphology reflected by a surface over which the CAAC-OS film is formed (hereinafter, a surface over which the CAAC-OS film is formed is referred to as a formation surface) or a top surface of the CAAC-OS film, and is arranged in parallel to the formation surface or the top surface of the CAAC-OS film.", "On the other hand, according to the TEM image of the CAAC-OS film observed in a direction substantially perpendicular to the sample surface (plan TEM image), metal atoms are arranged in a triangular or hexagonal configuration in the crystal parts.", "However, there is no regularity of arrangement of metal atoms between different crystal parts.", "From the results of the cross-sectional TEM image and the plan TEM image, alignment is found in the crystal parts in the CAAC-OS film.", "A CAAC-OS film is subjected to structural analysis with an X-ray diffraction (XRD) apparatus.", "For example, when the CAAC-OS film including an InGaZnO4 crystal is analyzed by an out-of-plane method, a peak appears frequently when the diffraction angle (2θ) is around 31°.", "This peak is derived from the (009) plane of the InGaZnO4 crystal, which indicates that crystals in the CAAC-OS film have c-axis alignment, and that the c-axes are aligned in a direction substantially perpendicular to the formation surface or the top surface of the CAAC-OS film.", "On the other hand, when the CAAC-OS film is analyzed by an in-plane method in which an X-ray enters a sample in a direction perpendicular to the c-axis, a peak appears frequently when 2θ is around 56°.", "This peak is derived from the (110) plane of the InGaZnO4 crystal.", "Here, analysis (ϕ scan) is performed under conditions where the sample is rotated around a normal vector of a sample surface as an axis (ϕ axis) with 2θ fixed at around 56°.", "In the case where the sample is a single-crystal oxide semiconductor film of InGaZnO4, six peaks appear.", "The six peaks are derived from crystal planes equivalent to the (110) plane.", "On the other hand, in the case of a CAAC-OS film, a peak is not clearly observed even when ϕ scan is performed with 2θ fixed at around 56°.", "According to the above results, in the CAAC-OS film having c-axis alignment, while the directions of a-axes and b-axes are different between crystal parts, the c-axes are aligned in a direction parallel to a normal vector of a formation surface or a normal vector of a top surface.", "Thus, each metal atom layer arranged in a layered manner observed in the cross-sectional TEM image corresponds to a plane parallel to the a-b plane of the crystal.", "Note that the crystal part is formed concurrently with deposition of the CAAC-OS film or is formed through crystallization treatment such as heat treatment.", "As described above, the c-axis of the crystal is aligned with a direction parallel to a normal vector of a formation surface or a normal vector of a top surface of the CAAC-OS film.", "Thus, for example, in the case where a shape of the CAAC-OS film is changed by etching or the like, the c-axis might not be necessarily parallel to the normal vector of the formation surface or the normal vector of the top surface of the CAAC-OS film.", "Further, the degree of crystallinity in the CAAC-OS film is not necessarily uniform.", "For example, in the case where crystal growth leading to the CAAC-OS film occurs from the vicinity of the top surface of the film, the degree of the crystallinity in the vicinity of the top surface is higher than that in the vicinity of the formation surface in some cases.", "Further, when an impurity is added to the CAAC-OS film, the crystallinity in a region to which the impurity is added is changed, and the degree of crystallinity in the CAAC-OS film varies depending on regions.", "Note that when the CAAC-OS film with an InGaZnO4 crystal is analyzed by an out-of-plane method, a peak of 2θ may also be observed at around 36°, in addition to the peak of 2θ at around 31°.", "The peak of 2θ at around 36° indicates that a crystal having no c-axis alignment is included in part of the CAAC-OS film.", "It is preferable that in the CAAC-OS film, a peak of 2θ appear at around 31° and a peak of 2θ do not appear at around 36°.", "In a transistor using the CAAC-OS film, a change in electrical characteristics due to irradiation with visible light or ultraviolet light is small.", "Thus, the transistor has high reliability.", "Alternatively, the oxide semiconductor film 19 may have a stacked-layer structure of a plurality of oxide semiconductor films.", "For example, the oxide semiconductor film 19 may have a stacked-layer structure of a first oxide semiconductor film and a second oxide semiconductor film which are formed using metal oxides with different compositions.", "Alternatively, for example, the first oxide semiconductor film may be formed using any of a two-component metal oxide, a three-component metal oxide, and a four-component metal oxide, and the second oxide semiconductor film may be formed using any of these which is different from the oxide for the first oxide semiconductor film.", "Further, the constituent elements of the first oxide semiconductor film and the second oxide semiconductor film may be made the same and the composition of the constituent elements of the first oxide semiconductor film and the second oxide semiconductor film may be made different.", "For example, the first oxide semiconductor film may contain In, Ga, and Zn at an atomic ratio of 3:1:2, and the second oxide semiconductor film may contain In, Ga, and Zn at an atomic ratio of 1:1:1.Alternatively, the first oxide semiconductor film may contain In, Ga, and Zn at an atomic ratio of 2:1:3, and the second oxide semiconductor film may contain In, Ga, and Zn at an atomic ratio of 1:3:2.Note that a proportion of each atom in the atomic ratio of the oxide semiconductor varies within a range of ±20% as an error.", "At this time, one of the first oxide semiconductor film and the second oxide semiconductor film, which is closer to the gate electrode (on the channel side), preferably contains In and Ga at a proportion of In>Ga.", "The other oxide semiconductor film, which is farther from the gate electrode (on the back channel side) preferably contains In and Ga at a proportion of In≤Ga.", "Further, the oxide semiconductor film 19 may have a three-layer structure of a first oxide semiconductor film, a second oxide semiconductor film, and a third oxide semiconductor film, in which the constituent elements thereof is made the same and the composition of the constituent elements of the first oxide semiconductor film, the second oxide semiconductor film, and the third oxide semiconductor film is made different.", "For example, the first oxide semiconductor film may contain In, Ga, and Zn at an atomic ratio of 1:3:2, the second oxide semiconductor film may contain In, Ga, and Zn at an atomic ratio of 3:1:2, and the third oxide semiconductor film may contain In, Ga, and Zn at an atomic ratio of 1:1:1.As compared to an oxide semiconductor film containing more In than Ga and Zn at an atomic ratio, typically, the second oxide semiconductor film, and an oxide semiconductor film containing Ga, Zn, and In at the same atomic ratio, typically, the third oxide semiconductor film, an oxide semiconductor film which contains less In than Ga and Zn at an atomic ratio, typically, the first oxide semiconductor film containing In, Ga, and Zn at an atomic ratio of 1:3:2, has few oxygen vacancies, and thus can suppress an increase in carrier density.", "Further, when the first oxide semiconductor film containing In, Ga, and Zn at an atomic ratio of 1:3:2 has an amorphous structure, the second oxide semiconductor film is likely to be a CAAC-OS film.", "Since the constituent elements of the first oxide semiconductor film, the second oxide semiconductor film, and the third oxide semiconductor film are the same, the first oxide semiconductor film has fewer trap levels at the interface with the second oxide semiconductor film.", "Therefore, when the oxide semiconductor film 19 has the above structure, the amount of change in threshold voltage of the transistor due to a change over time or a BT photostress test can be reduced.", "In an oxide semiconductor, the s orbital of heavy metal mainly contributes to carrier transfer, and when the In content in the oxide semiconductor is increased, overlap of the s orbitals is likely to be increased.", "Therefore, an oxide containing In and Ga at a proportion of In>Ga has higher carrier mobility than an oxide containing In and Ga at a proportion of In≤Ga.", "Further, in Ga, the formation energy of an oxygen vacancy is larger and thus an oxygen vacancy is less likely to occur, than in In; therefore, the oxide containing In and Ga at a proportion of In≤Ga has more stable characteristics than the oxide containing In and Ga at a proportion of In>Ga.", "An oxide semiconductor containing In and Ga at a proportion of In>Ga is used on the channel side, and an oxide semiconductor containing In and Ga at a proportion of In≤Ga is used on the back channel side, so that the field-effect mobility and the reliability of the transistor can be further improved.", "Further, the first oxide semiconductor film, the second oxide semiconductor film, and the third oxide semiconductor film may be formed using oxide semiconductors having different crystallinity.", "That is, these oxide semiconductor films may be formed using any of a single crystal oxide semiconductor, a polycrystalline oxide semiconductor, an amorphous oxide semiconductor, and a CAAC-OS, as appropriate.", "When an amorphous oxide semiconductor is used for either the first oxide semiconductor film or the second oxide semiconductor film, internal stress or external stress of the oxide semiconductor film 19 is relieved, variation in characteristics of the transistor is reduced, and the reliability of the transistor can be further improved.", "The thickness of the oxide semiconductor film 19 is preferably greater than or equal to 1 nm and less than or equal to 100 nm, more preferably greater than or equal to 1 nm and less than or equal to 30 nm, still more preferably greater than or equal to 1 nm and less than or equal to 50 nm, further preferably greater than or equal to 3 nm and less than or equal to 20 nm.", "The concentration of alkali metals or alkaline earth metals in the oxide semiconductor film 19, which is obtained by secondary ion mass spectrometry (SIMS), is preferably lower than or equal to 1×1018 atoms/cm3, more preferably lower than or equal to 2×1016 atoms/cm3.This is because, when alkali metals or alkaline earth metals are bonded to an oxide semiconductor, some of the alkali metals or the alkaline earth metals generate carriers and cause an increase in the off-state current of the transistor.", "In the oxide semiconductor film 19, the hydrogen concentration obtained by secondary ion mass spectrometry is preferably smaller than 5×1018 atoms/cm3, further preferably smaller than or equal to 1×1018 atoms/cm3, still further preferably smaller than or equal to 5×1017 atoms/cm3, yet still further preferably smaller than or equal to 1×1016 atoms/cm3.Hydrogen contained in the oxide semiconductor film 19 reacts with oxygen bonded to a metal atom to produce water, and a defect is formed in a lattice from which oxygen is released (or a portion from which oxygen is removed).", "In addition, a bond of part of hydrogen and oxygen causes generation of electrons serving as a carrier.", "Thus, the impurities containing hydrogen are reduced as much as possible in the step of forming the oxide semiconductor film, whereby the hydrogen concentration in the oxide semiconductor film can be reduced.", "Therefore, an oxide semiconductor film in which hydrogen is removed as much as possible is used in a channel formation region, whereby a shift of the threshold voltage in the negative direction can be suppressed and variation in electrical characteristics can be reduced.", "Further, leakage current between a source and a drain of the transistor, typically off-state current, can be reduced.", "In addition, the nitrogen concentration in the oxide semiconductor film 19 is set to be lower than or equal to 5×1018 atoms/cm3, whereby a shift of the threshold voltage in the negative direction can be suppressed and variation in electrical characteristics can be reduced.", "Various experiments can prove low off-state current of a transistor including a highly-purified oxide semiconductor film from which hydrogen is removed as much as possible as a channel formation region.", "For example, even when an element has a channel width of 1×106 μm and a channel length of 10 μm, off-state current can be less than or equal to the measurement limit of a semiconductor parameter analyzer, i.e., less than or equal to 1×10−13 A, at voltage (drain voltage) between the source electrode and the drain electrode of from 1 V to 10 V. In this case, it can be seen that the off-state current is 100 zA/μm or lower.", "Further, the off-state current was measured with the use of a circuit in which a capacitor and a transistor are connected to each other and charge that flows in or out from the capacitor is controlled by the transistor.", "In the measurement, a purified oxide semiconductor film has been used for a channel formation region of the transistor, and the off-state current of the transistor has been measured from a change in the amount of charge of the capacitor per unit time.", "As a result, it is found that in the case where the voltage between the source electrode and the drain electrode of the transistor is 3 V, lower off-state current of several tens of yoctoamperes per micrometer (yA/μm) can be obtained.", "Consequently, the transistor including the highly purified oxide semiconductor film as the channel formation region has extremely small off-state current.", "The pair of electrodes 21 is formed to have a single-layer structure or a stacked-layer structure including, as a conductive material, any of metals such as aluminum, titanium, chromium, nickel, copper, yttrium, zirconium, molybdenum, silver, tantalum, and tungsten or an alloy containing any of these metals as its main component.", "A single-layer structure of an aluminum film containing silicon; a two-layer structure in which a titanium film is stacked over an aluminum film; a two-layer structure in which a titanium film is stacked over a tungsten film; a two-layer structure in which a copper film is formed over a copper-magnesium-aluminum alloy film; a three-layer structure in which a titanium film or a titanium nitride film, an aluminum film or a copper film, and a titanium film or a titanium nitride film are stacked in this order; and a three-layer structure in which a molybdenum film or a molybdenum nitride film, an aluminum film or a copper film, and a molybdenum film or a molybdenum nitride film are stacked in this order can be given as examples.", "Note that a transparent conductive material containing indium oxide, tin oxide, or zinc oxide may be used.", "Although the pair of electrodes 21 is provided between the oxide semiconductor film 19 and the insulating film 23 in this embodiment, the pair of electrodes 21 may be provided between the gate insulating film 18 and the oxide semiconductor film 19.In order to improve the characteristics of the interface between the insulating film 23 and the oxide semiconductor film 19, an oxide insulating film is preferably used as the insulating film 23.As the insulating film 23, silicon oxide, silicon oxynitride, aluminum oxide, hafnium oxide, gallium oxide, Ga—Zn-based metal oxide, or the like with a thickness more than or equal to 150 nm and less than or equal to 400 nm can be used.", "Next, a method for manufacturing the transistor 1 illustrated in FIGS.", "1A and 1B is described with reference to FIGS.", "2A to 2D.", "As illustrated in FIG.", "2A, the gate electrode 15 is formed over the substrate 11, and the gate insulating film 18 is formed over the gate electrode 15.A formation method of the gate electrode 15 is described below.", "First, a conductive film is formed by a sputtering method, a CVD method, an evaporation method, or the like and then a mask is formed over the conductive film by a photolithography process.", "Then, part of the conductive film is etched using the mask to form the gate electrode 15.After that, the mask is removed.", "Note that instead of the above formation method, the gate electrode 15 may be formed by an electrolytic plating method, a printing method, an ink-jet method, or the like.", "Here, a 100-nm-thick tungsten film is formed by a sputtering method.", "Then, a mask is formed by a photolithography process and the tungsten film is dry-etched using the mask to form the gate electrode 15.The gate insulating film 18 is formed by a sputtering method, a CVD method, an evaporation method, or the like.", "In the case where the gate insulating film 18 is formed using a silicon oxide film or a silicon oxynitride film, a deposition gas containing silicon and an oxidizing gas are preferably used as a source gas.", "As typical examples of the deposition gas containing silicon, silane, disilane, trisilane, and silane fluoride can be given.", "As the oxidizing gas, oxygen, ozone, dinitrogen monoxide, nitrogen dioxide, and the like can be given as examples.", "Further, in the case where a stacked structure of a silicon nitride film and an oxide insulating film is formed as the gate insulating film 18, the silicon nitride film is preferably stacked by a two-step formation method.", "First, a first silicon nitride film with few defects is formed by a plasma CVD method in which a mixed gas of silane, nitrogen, and ammonia is used as a source gas.", "Then, by using a source gas at a flow rate ratio which is similar to that of a source gas used for the nitride insulating film 25 described later, a silicon nitride film which releases the small number of hydrogen molecules and ammonia molecules can be formed as the second silicon nitride film.", "With such a formation method, a silicon nitride film which has few defects and releases the small number of hydrogen molecules and ammonia molecules can be formed as the gate insulating film 18.Moreover, in the case where a gallium oxide film is formed as the gate insulating film 18, a metal organic chemical vapor deposition (MOCVD) method can be used.", "Here, by a plasma CVD method, the gate insulating film 18 in which the first silicon nitride film with a thickness of 300 nm, the second silicon nitride film with a thickness of 50 nm, and the silicon oxynitride film with a thickness of 50 nm are stacked is formed.", "Next, as illustrated in FIG.", "2B, an oxide semiconductor film 19 is formed over the gate insulating film 18.A formation method of the oxide semiconductor film 19 is described below.", "An oxide semiconductor film is formed over the gate insulating film 18 by a sputtering method, a coating method, a pulsed laser deposition method, a laser ablation method, or the like.", "Then, after a mask is formed over the oxide semiconductor film by a photolithography process, the oxide semiconductor film is partly etched using the mask.", "Accordingly, the oxide semiconductor film 19 which is over the gate insulating film 18 and subjected to element isolation so as to partly overlap with the gate electrode 15 is formed as illustrated in FIG.", "2B.", "After that, the mask is removed.", "Alternatively, by using a printing method for forming the oxide semiconductor film 19, the oxide semiconductor film 19 subjected to element isolation can be formed directly.", "In the case where the oxide semiconductor film is formed by a sputtering method, a power supply device for generating plasma can be an RF power supply device, an AC power supply device, a DC power supply device, or the like as appropriate.", "As a sputtering gas, a rare gas (typically argon), an oxygen gas, or a mixed gas of a rare gas and oxygen is used as appropriate.", "In the case of using the mixed gas of a rare gas and oxygen, the proportion of oxygen is preferably higher than that of a rare gas.", "Further, a target may be appropriately selected in accordance with the composition of the oxide semiconductor film to be formed.", "For example, in the case where the oxide semiconductor film is formed by a sputtering method at a substrate temperature higher than or equal to 150° C. and lower than or equal to 750° C., preferably higher than or equal to 150° C. and lower than or equal to 450° C., more preferably higher than or equal to 200° C. and lower than or equal to 350° C., the oxide semiconductor film can be a CAAC-OS film.", "A CAAC-OS film is formed by, for example, a sputtering method using a polycrystalline oxide semiconductor sputtering target.", "When ions collide with the sputtering target, a crystal region included in the sputtering target might be separated from the target along an a-b plane; in other words, a sputtered particle having a plane parallel to an a-b plane (flat-plate-like sputtered particle or pellet-like sputtered particle) might be separated from the sputtering target.", "In that case, the flat-plate-like sputtered particle reaches a substrate while maintaining their crystal state, whereby the CAAC-OS film can be deposited.", "For the deposition of the CAAC-OS film, the following conditions are preferably used.", "By suppressing the number of impurities entering the CAAC-OS film during the deposition, the crystal state can be prevented from being broken by the impurities.", "For example, reducing the concentration of impurities (e.g., hydrogen, water, carbon dioxide, and nitrogen) which exist in the deposition chamber is favorable.", "Furthermore, the concentration of impurities in a deposition gas can be reduced.", "Specifically, a deposition gas whose dew point is lower than or equal to −80° C., preferably lower than or equal to −100° C., can be used.", "By increasing the substrate heating temperature during the deposition, migration of a sputtered particle is likely to occur after the sputtered particle reaches a substrate surface.", "Specifically, the substrate heating temperature during the deposition is higher than or equal to 100° C. and lower than the strain point of the substrate, preferably higher than or equal to 200° C. and lower than or equal to 500° C. By increasing the substrate heating temperature during the deposition, when the flat-plate-like sputtered particle reaches the substrate, migration occurs on the substrate surface, so that a flat plane of the flat-plate-like sputtered particle is attached to the substrate.", "Furthermore, it is preferable that the proportion of oxygen in the deposition gas be increased and the power be optimized in order to reduce plasma damage at the deposition.", "The proportion of oxygen in the deposition gas is higher than or equal to 30 vol %, preferably 100 vol %.", "As an example of the sputtering target, an In—Ga—Zn-based metal oxide target is described below.", "The In—Ga—Zn-based metal oxide target, which is polycrystalline, is made by mixing InOX powder, GaOY powder, and ZnOZ powder in a predetermined molar ratio, applying pressure, and performing heat treatment at a temperature higher than or equal to 1000° C. and lower than or equal to 1500° C. Note that X, Y, and Z are each a given positive number.", "Here, the predetermined molar ratio of InOX powder to GaOY powder and ZnOZ powder is, for example, 2:2:1, 8:4:3, 3:1:1, 1:1:1, 4:2:3, or 3:1:2.The kinds of powder and the molar ratio for mixing powder may be determined as appropriate depending on the desired sputtering target.", "Further, after the oxide semiconductor film is formed, heat treatment may be performed so that the oxide semiconductor film is subjected to dehydrogenation or dehydration.", "The heating temperature is typically higher than or equal to 150° C. and lower than the strain point of the substrate, preferably higher than or equal to 250° C. and lower than or equal to 450° C., more preferably higher than or equal to 300° C. and lower than or equal to 450° C. The heat treatment is performed under an inert gas atmosphere containing nitrogen or a rare gas such as helium, neon, argon, xenon, or krypton.", "Alternatively, the heat treatment may be performed under an inert gas atmosphere first, and then under an oxygen atmosphere.", "It is preferable that the above inert gas atmosphere and the above oxygen atmosphere do not contain hydrogen, water, and the like.", "The treatment time is 3 minutes to 24 hours.", "An electric furnace, an RTA apparatus, or the like can be used for the heat treatment.", "With the use of an RTA apparatus, the heat treatment can be performed at a temperature of higher than or equal to the strain point of the substrate if the heating time is short.", "Therefore, the heat treatment time can be shortened.", "By performing heat treatment after the oxide semiconductor film is formed, in the oxide semiconductor film, the concentration of hydrogen can be smaller than 5×1018 atoms/cm3, preferably smaller than or equal to 1×1018 atoms/cm3, further preferably smaller than or equal to 5×1017 atoms/cm3, still further preferably smaller than or equal to 1×1016 atoms/cm3.Here, a 35-nm-thick oxide semiconductor film is formed by a sputtering method, a mask is formed over the oxide semiconductor film, and then part of the oxide semiconductor film is selectively etched.", "Next, after the mask is removed, heat treatment is performed in an atmosphere of nitrogen and oxygen, so that the oxide semiconductor film 19 is formed.", "Next, as illustrated in FIG.", "2C, the pair of electrodes 21 is formed.", "A formation method of the pair of electrodes 21 is described below.", "First, a conductive film is formed by a sputtering method, a CVD method, an evaporation method, or the like.", "Then, a mask is formed over the conductive film by a photolithography process.", "After that, the conductive film is etched using the mask to form the pair of electrodes 21.Then, the mask is removed.", "Here, a 50-nm-thick tungsten film, a 400-nm-thick aluminum film, and a 100-nm-thick titanium film are sequentially stacked by a sputtering method.", "Then, a mask is formed over the titanium film by a photolithography process and the tungsten film, the aluminum film, and the titanium film are dry-etched using the mask to form the pair of electrodes 21.Note that heat treatment may be performed after the pair of electrodes 21 is formed.", "This heat treatment can be performed in a manner similar to that of the heat treatment performed after the oxide semiconductor film 19 is formed.", "After the pair of electrodes 21 is formed, cleaning treatment is preferably performed to remove an etching residue.", "A short circuit of the pair of electrodes 21 can be suppressed by this cleaning treatment.", "The cleaning treatment can be performed using an alkaline solution such as a tetramethylammonium hydroxide (TMAH) solution; an acidic solution such as a hydrofluoric acid solution or an oxalic acid solution; or water.", "Next, the insulating film 23 is formed over the oxide semiconductor film 19 and the pair of electrodes 21.The insulating film 23 can be formed by a sputtering method, a CVD method, an evaporation method, or the like.", "Here, as the insulating film 23, a silicon oxide film or a silicon oxynitride film is formed by a plasma CVD method.", "Next, heat treatment may be performed.", "The temperature of the heat treatment is typically higher than or equal to 150° C. and lower than the strain point of the substrate, preferably higher than or equal to 200° C. and lower than or equal to 450° C., more preferably higher than or equal to 300° C. and lower than or equal to 450° C. By the heat treatment, water, hydrogen, and the like contained in the insulating film 23 can be released.", "Here, the heat treatment is performed at 350° C. for one hour in an atmosphere of nitrogen and oxygen.", "Next, the nitride insulating film 25 is formed over the insulating film 23.The nitride insulating film 25 can be formed by a sputtering method, a CVD method, or the like.", "In the case where a silicon nitride film is formed by the plasma CVD method as the nitride insulating film 25, a deposition gas containing silicon, nitrogen, and ammonia is used as the source gas.", "As the source gas, a small amount of ammonia compared to the amount of nitrogen is used, whereby ammonia is dissociated in the plasma and activated species are generated.", "The activated species cleave a bond between silicon and hydrogen which are contained in a deposition gas containing silicon and a triple bond between nitrogen molecules.", "As a result, a dense silicon nitride film having few defects, in which a bond between silicon and nitrogen is promoted and a bond between silicon and hydrogen is few can be formed.", "On the other hand, when the amount of ammonia with respect to nitrogen is large in a source gas, cleavage of a deposition gas containing silicon and cleavage of nitrogen are not promoted, so that a sparse silicon nitride film in which a bond between silicon and hydrogen remains and defects are increased is formed.", "Therefore, in a source gas, a flow ratio of the nitrogen to the ammonia is set to be greater than or equal to 5 and less than or equal to 50, preferably greater than or equal to 10 and less than or equal to 50.Here, in a reaction chamber of a plasma CVD apparatus, the 50-nm-thick silicon nitride film is formed by a plasma CVD method under the following conditions: silane with a flow rate of 50 sccm, nitrogen with a flow rate of 5000 sccm, and ammonia with a flow rate of 100 sccm are used as a source gas, the pressure in the treatment chamber is 200 Pa, the substrate temperature is 220° C., and high-frequency power of 1000 W is supplied to parallel-plate electrodes with a high-frequency power supply of 27.12 MHz.", "Note that the plasma CVD apparatus is a parallel-plate plasma CVD apparatus in which the electrode area is 6000 cm2, and the power per unit area (power density) into which the supplied power is converted is 1.7×10−1 W/cm2.Through the above steps, a protective film 26 including the insulating film 23 and the nitride insulating film 25 which releases the small number of hydrogen molecules and ammonia molecules can be formed.", "Next, heat treatment may be performed.", "The temperature of the heat treatment is typically higher than or equal to 150° C. and lower than the strain point of the substrate, preferably higher than or equal to 200° C. and lower than or equal to 450° C., more preferably higher than or equal to 300° C. and lower than or equal to 450° C. Through the above steps, a nitride insulating film which releases the small amount of hydrogen molecules and ammonia molecules can be formed over a transistor including an oxide semiconductor film.", "Further, a transistor with the improved reliability, in which a change in electrical characteristics is suppressed, can be manufactured.", "Note that the structures, methods, and the like described in this embodiment can be used as appropriate in combination with any of the structures, methods, and the like described in the other embodiments and examples.", "Embodiment 2 In this embodiment, a transistor having a structure different from that of Embodiment 1 will be described with reference to FIGS.", "3A and 3B.", "A transistor 3 shown in this embodiment is a top-gate transistor, which is different from the transistors in Embodiment 1.FIGS.", "3A and 3B are a top view and a cross-sectional view of the transistor 3.FIG.", "3A is a top view of the transistor 3, and FIG.", "3B is a cross-sectional view taken along dashed-dotted line A-B in FIG.", "3A.", "Note that in FIG.", "3A, a substrate 31, a base insulating film 33, some components of the transistor 3 (e.g., an insulating film 37 and a nitride insulating film 39), and the like are omitted for simplicity.", "The transistor 3 illustrated in FIGS.", "3A and 3B includes an oxide semiconductor film 34 over the base insulating film 33, a pair of electrodes 35 in contact with the oxide semiconductor film 34, a gate insulating film 40 in contact with the base insulating film 33, the oxide semiconductor film 34, and the pair of electrodes 35, and a gate electrode 41 overlapping with the oxide semiconductor film 34 with the gate insulating film 40 provided therebetween.", "The gate insulating film 40 provided in the transistor 3 in this embodiment includes an insulating film 37 and a nitride insulating film 39.As the insulating film 37, the oxide insulating film used as the gate insulating film 18 in Embodiment 1 is used as appropriate, whereby the interface state between the oxide semiconductor film 34 and the gate insulating film 40 can be reduced.", "As the nitride insulating film 39, a nitride insulating film like the nitride insulating film 25 in Embodiment 1 can be used, which releases hydrogen molecules less than 5×1021 molecules/cm3, preferably less than or equal to 3×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3, and ammonia molecules less than 1×1022 molecules/cm3, preferably less than or equal to 5×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3 by thermal desorption spectroscopy.", "The number of hydrogen molecules and the number of ammonia molecules which are released from the nitride insulating film 39 are small; thus, the amount of hydrogen and nitrogen which are moved to the oxide semiconductor film 34 in the transistor 3 is small.", "As a result, in the transistor 3, the amount of hydrogen and nitrogen which are moved from the gate insulating film 40 to the oxide semiconductor film 34 is small and the concentration of hydrogen and nitrogen in the oxide semiconductor film 34 can be reduced.", "Further, the nitride insulating film 39 is included in the gate insulating film in the transistor 3, whereby entry of water from the outside to the oxide semiconductor film 34 can be suppressed.", "In other words, entry of hydrogen contained in water to the oxide semiconductor film 34 can be suppressed.", "As a result, a shift of the threshold voltage in the negative direction can be suppressed and variation in electrical characteristics can be reduced.", "Further, leakage current between a source and a drain of the transistor, typically off-state current, can be reduced.", "Hereinafter, other details of the transistor 3 will be described.", "As the substrate 31, a substrate which is given as an example of the substrate 11 in Embodiment 1 can be used as appropriate.", "As the base insulating film 33, an oxide insulating film whose oxygen content is in excess of that in the stoichiometric composition is preferably used.", "The oxide insulating film whose oxygen content is in excess of that in the stoichiometric composition can diffuse oxygen into an oxide semiconductor film by heat treatment.", "Typical examples of the base insulating film 33 are films of silicon oxide, silicon oxynitride, silicon nitride oxide, gallium oxide, hafnium oxide, yttrium oxide, aluminum oxide, aluminum oxynitride, and the like.", "The thickness of the base insulating film 33 is greater than or equal to 50 nm, preferably greater than or equal to 200 nm and less than or equal to 3000 nm, more preferably greater than or equal to 300 nm and less than or equal to 1000 nm.", "With use of the thick base insulating film 33, the number of oxygen molecules released from the base insulating film 33 can be increased, and the interface state density at the interface between the base insulating film 33 and an oxide semiconductor film formed later can be reduced.", "Here, “to release part of oxygen by heating” means that the amount of released oxygen by conversion into oxygen atoms is greater than or equal to 1×1018 atoms/cm3, preferably greater than or equal to 3×1020 atoms/cm3 in TDS analysis.", "The oxide semiconductor film 34 can be formed in a manner similar to that of the oxide semiconductor film 19 in Embodiment 1.The pair of electrodes 35 can be formed in a manner similar to that of the pair of electrodes 21 shown in Embodiment 1.Note that the length of the pair of electrodes 35 in the channel width direction is larger than that of the oxide semiconductor film 34, and seen in the cross section in the channel length direction, the pair of electrodes 35 covers end portions of the oxide semiconductor film 34.With such a structure, the area of contact between the pair of electrodes 35 and the oxide semiconductor film 34 is increased.", "Thus, the contact resistance between the oxide semiconductor film 34 and the pair of electrodes 35 can be reduced, and the on-state current of the transistor can be increased.", "In this embodiment, the pair of electrodes 35 is provided between the oxide semiconductor film 34 and the insulating film 37; however, the pair of electrodes 35 may be provided between the base insulating film 33 and the oxide semiconductor film 34.Further, the insulating film 23 and the nitride insulating film 25 are provided over the gate insulating film 40 and the gate electrode 41 in the same manner as in Embodiment 1, whereby entry of water from the outside to the transistor 3 including the oxide semiconductor film can be further suppressed.", "The gate electrode 41 can be formed in a manner similar to that of the gate electrode 15 in Embodiment 1.Next, a method for manufacturing the transistor illustrated in FIGS.", "3A and 3B will be described with reference to FIGS.", "4A to 4D.", "As illustrated in FIG.", "4A, the base insulating film 33 is formed over the substrate 31.Next, the oxide semiconductor film 34 is formed over the base insulating film 33.The base insulating film 33 is formed by a sputtering method, a CVD method or the like.", "When the oxide insulating film from which part of oxygen is released by heating is formed by a sputtering method as the base insulating film 33, the amount of oxygen in a deposition gas is preferably large, and oxygen, a mixed gas of oxygen and a rare gas, or the like can be used.", "Typically, the oxygen concentration of a deposition gas is preferably from 6% to 100%.", "In the case where an oxide insulating film is formed by a CVD method as the base insulating film 33, hydrogen or water derived from a source gas is sometimes mixed in the oxide insulating film.", "Thus, after the oxide insulating film is formed by a CVD method, heat treatment is preferably performed as dehydrogenation or dehydration.", "In the case of adding oxygen to the oxide insulating film formed by a CVD method, the amount of oxygen released by heating can be increased.", "As the method for adding oxygen to the oxide insulating film, an ion implantation method, an ion doping method, a plasma immersion ion implantation method, plasma treatment, or the like is used.", "The oxide semiconductor film 34 can be formed as appropriate by a formation method similar to that of the oxide semiconductor film 19 described in Embodiment 1.In order to improve the orientation of the crystal parts in the CAAC-OS film, planarity of the surface of the base insulating film 33 serving as a base insulating film of the oxide semiconductor film is preferably improved.", "Typically, the base insulating film 33 can be made to have an average surface roughness (Ra) of 1 nm or less, 0.3 nm or less, or 0.1 nm or less.", "Note that Ra is obtained by expanding, into three dimensions, the arithmetic mean surface roughness defined by JIS B 0601 so that it can be applied to a curved surface, and Ra can be expressed as an “average value of the absolute values of deviations from a reference surface to a specific surface” and is defined by Formula 2.", "[ FORMULA   2 ]  Ra = 1 S 0  ∫ y   1 y   2  ∫ x   1 x   2   f  ( x , y ) - Z 0   dxdy  ( 2 ) Here, the specific surface is a surface which is a target of roughness measurement, and is a quadrilateral region which is specified by four points represented by the coordinates (x1, y1, f(x1, y1)), (x1, y2, f(x1, y2)), (x2, y1, y1)), and (x2, y2, f(x2, y2)).", "S0 represents the area of a rectangle which is obtained by projecting the specific surface on the xy plane, and Z0 represents the height of the reference surface (the average height of the specific surface).", "Ra can be measured using an atomic force microscope (AFM).", "As planarization treatment for improving planarity of the surface of the base insulating film 33, one or more can be selected from chemical mechanical polishing (CMP) treatment, dry etching treatment, plasma treatment (reverse sputtering), and the like.", "The plasma treatment is the one in which minute unevenness of the surface is reduced by introducing an inert gas such as an argon gas into a vacuum chamber and applying an electric field so that a surface to be processed serves as a cathode.", "Next, heat treatment is preferably performed.", "By this heat treatment, part of oxygen contained in the base insulating film 33 can be diffused to the vicinity of the interface between the base insulating film 33 and the oxide semiconductor film 34.As a result, the interface state in the vicinity of the interface between the base insulating film 33 and the oxide semiconductor film 34 can be reduced.", "The temperature of the heat treatment is typically higher than or equal to 150° C. and lower than the strain point of the substrate, preferably higher than or equal to 250° C. and lower than or equal to 450° C., more preferably higher than or equal to 300° C. and lower than or equal to 450° C. The heat treatment is performed under an inert gas atmosphere containing nitrogen or a rare gas such as helium, neon, argon, xenon, or krypton.", "Alternatively, the heat treatment may be performed under an inert gas atmosphere first, and then under an oxygen atmosphere.", "It is preferable that the above inert gas atmosphere and the above oxygen atmosphere do not contain hydrogen, water, and the like.", "The treatment time is 3 minutes to 24 hours.", "Next, as illustrated in FIG.", "4B, the pair of electrodes 35 is formed.", "The pair of electrodes 35 can be formed as appropriate by a formation method similar to that of the pair of electrodes 21 described in Embodiment 1.Alternatively, the pair of electrodes 35 can be formed by a printing method or an inkjet method.", "Next, as illustrated in FIG.", "4C, the insulating film 37 and the nitride insulating film 39 included in the gate insulating film 40 are formed.", "The insulating film 37 is formed by a sputtering method, a CVD method, an evaporation method, or the like.", "As the nitride insulating film 39, in a similar manner to the nitride insulating film 25 in Embodiment 1, a nitride insulating film which releases hydrogen molecules less than 5×1021 molecules/cm3, preferably less than or equal to 3×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3, and ammonia molecules less than 1×1022 molecules/cm3, preferably less than or equal to 5×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3 by thermal desorption spectroscopy can be formed.", "Next, as illustrated in FIG.", "4D, the gate electrode 41 is formed over the gate insulating film 40.The gate electrode 41 can be formed as appropriate by a formation method similar to that of the gate electrode 15 in Embodiment 1.Next, in a manner similar to that in Embodiment 1, heat treatment may be performed.", "The temperature of the heat treatment is typically higher than or equal to 150° C. and lower than the strain point of the substrate, preferably higher than or equal to 250° C. and lower than or equal to 450° C., more preferably higher than or equal to 300° C. and lower than or equal to 450° C. Through the above steps, a transistor with the improved reliability, in which a change in electrical characteristics is suppressed, can be manufactured.", "Note that the structures, methods, and the like described in this embodiment can be used as appropriate in combination with any of the structures, methods, and the like described in the other embodiments and examples.", "Embodiment 3 In this embodiment, a transistor having a different structure from the transistors in Embodiment 1 and Embodiment 2 will be described with reference to FIG.", "5.A transistor 5 of this embodiment includes a plurality of gate electrodes facing each other with an oxide semiconductor film provided therebetween.", "The transistor 5 illustrated in FIG.", "5 includes the gate electrode 15 provided over the substrate 11, the gate insulating film 18 formed over the substrate 11 and the gate electrode 15, the oxide semiconductor film 19 overlapping with the gate electrode 15 with the gate insulating film 18 provided therebetween, and the pair of electrodes 21 in contact with the oxide semiconductor film 19.The protective film 26 including the insulating film 23 and the nitride insulating film 25 is formed over the gate insulating film 18, the oxide semiconductor film 19, and the pair of electrodes 21.Further, a gate electrode 61 overlapping with the oxide semiconductor film 19 with the protective film 26 provided therebetween is included.", "The gate electrode 61 can be formed in a manner similar to that of the gate electrode 15 in Embodiment 1.The transistor 5 of this embodiment has the gate electrode 15 and the gate electrode 61 facing each other with the oxide semiconductor film 19 provided therebetween.", "By application of different potentials to the gate electrode 15 and the gate electrode 61, the threshold voltage of the transistor 5 can be controlled.", "Alternatively, when the same potential is applied to the gate electrode 15 and the gate electrode 61, the on-state current of the transistor 5 can be increased.", "A nitride insulating film which releases hydrogen molecules less than 5×1021 molecules/cm3, preferably less than or equal to 3×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3, and ammonia molecules less than 1×1022 molecules/cm3, preferably less than or equal to 5×1021 molecules/cm3, more preferably less than or equal to 1×1021 molecules/cm3 by thermal desorption spectroscopy is provided between the oxide semiconductor film 19 and the gate electrode 61, whereby the amount of hydrogen and ammonia which are moved from the nitride insulating film to the oxide semiconductor film 19 can be small and concentration of hydrogen and nitrogen in the oxide semiconductor film 19 can be reduced.", "Further, the nitride insulating film 25 is provided between the oxide semiconductor film 19 and the gate electrode 61; therefore, entry of water from the outside to the oxide semiconductor film 19 can be suppressed.", "In other words, entry of hydrogen contained in water to the oxide semiconductor film 19 can be suppressed.", "As a result, a shift of the threshold voltage in the negative direction can be suppressed and variation in electrical characteristics can be reduced.", "Embodiment 4 In this embodiment, a structure of a transistor and a protective film in which movement of hydrogen and nitrogen to an oxide semiconductor film is suppressed and oxygen vacancies in the oxide semiconductor film can be reduced will be described with reference to FIGS.", "6A and 6B.", "Note that the description about the same structures as those in Embodiment 1 will be omitted.", "In a transistor using an oxide semiconductor, oxygen vacancies in an oxide semiconductor film cause defects of electrical characteristics of the transistor.", "For example, the threshold voltage of a transistor using an oxide semiconductor film with oxygen vacancies easily shifts in the negative direction, and such a transistor tends to be normally-on.", "This is because electric charges are generated owing to oxygen vacancies in the oxide semiconductor, and the resistance is reduced.", "Further, when the oxide semiconductor film includes an oxygen vacancy, as a problem, the amount of change in electrical characteristics, typically, the threshold voltage of the transistor is increased due to a change over time or a bias-temperature stress test (hereinafter also referred to as a BT stress test).", "In this embodiment, a transistor with excellent electrical characteristics in which a shift of the threshold voltage in the negative direction is suppressed and a manufacturing method thereof are described.", "In addition, a highly reliable transistor in which variation in electrical characteristics due to a change over time or a BT photostress test is small and a manufacturing method thereof are described.", "FIGS.", "6A and 6B are a top view and a cross-sectional view of a transistor 7 included in a semiconductor device.", "FIG.", "6A is a top view of the transistor 7, and FIG.", "6B is a cross-sectional view taken along dashed line A-B in FIG.", "6A.", "Note that in FIG.", "6A, the substrate 11, some components of the transistor 7 (e.g., the gate insulating film 18), an insulating film 24a, an insulating film 24b, the nitride insulating film 25, a planarization film 27, and the like are omitted for simplicity.", "The transistor 7 illustrated in FIGS.", "6A and 6B includes the gate electrode 15 provided over the substrate 11, the gate insulating film 18 formed over the substrate 11 and the gate electrode 15, an oxide semiconductor film 19 overlapping with the gate electrode 15 with the gate insulating film 18 provided therebetween, and a pair of electrodes 21 in contact with the oxide semiconductor film 19.A protective film 28 including the insulating film 24a, the insulating film 24b, and the nitride insulating film 25 is formed over the gate insulating film 18, the oxide semiconductor film 19, and the pair of electrodes 21.In addition, the planarization film 27 may be provided over the protective film 28.Moreover, in an opening 30 formed in the protective film 28 and the planarization film 27, a conductive film 29 connected to one of the pair of electrodes 21 may be provided.", "In the transistor 7 shown in this embodiment, the insulating film 24a is formed in contact with the oxide semiconductor film 19.The insulating film 24a is an oxide insulating film which transmits oxygen.", "Note that the insulating film 24a also functions as a film which relieves damage to the oxide semiconductor film 19 at the time of forming the insulating film 24b later.", "As the oxide insulating film which transmits oxygen, a silicon oxide film, a silicon oxynitride film, or the like having a thickness greater than or equal to 5 nm and less than or equal to 150 nm, preferably greater than or equal to 5 nm and less than or equal to 50 nm, more preferably greater than or equal to 10 nm and less than or equal to 30 nm can be used.", "Further, it is preferable that the number of defects be small in the insulating film 24a, and typically, the spin density of a signal at g=2.001 which is due to dangling bonds of silicon by ESR measurement be lower than or equal to 3×1017 spins/cm3, further preferably lower than or equal to 5×1016 spins/cm3.This is because, when defect density in the insulating film 24a is high, oxygen may be bonded to the defect and the transmittance of oxygen in the insulating film 24a is decreased.", "Further, it is preferable that the number of defects be small at an interface between the insulating film 24a and the oxide semiconductor film 19, and typically, the spin density of a signal at g=1.93 which is due to oxygen vacancies in the oxide semiconductor film by ESR measurement in which a magnetic field is applied in parallel to the surface of the film be lower than or equal to 1×1017 spins/cm3, further preferably lower than or equal to a lower limit of the detection.", "The spin density due to oxygen vacancies in the oxide semiconductor film 19 is lower than or equal to the above-described spin density, whereby in Vg-Id characteristics in the transistor including the oxide semiconductor film, variation in the gate voltage at which the transistor is turned on in the case where there is different drain voltages can be reduced.", "Note that all oxygen atoms entering the insulating film 24a from the outside are not moved to the outside of the insulating film 24a and some oxygen remains in the insulating film 24a in some cases.", "Further, oxygen enters the insulating film 24a and oxygen contained in the insulating film 24a is moved to the outside of the insulating film 24a, whereby movement of oxygen in the insulating film 24a occurs in some cases.", "By forming the oxide insulating film which transmits oxygen as the insulating film 24a, oxygen released from the oxide insulating film provided over the insulating film 24a, whose oxygen content is in excess of that in the stoichiometric composition, can be moved to the oxide semiconductor film 19 through the insulating film 24a.", "The insulating film 24b is formed to be in contact with the insulating film 24a.", "The insulating film 24b is formed using an oxide insulating film whose oxygen content is in excess of that in the stoichiometric composition.", "Such an oxide insulating film whose oxygen content is in excess of that in the stoichiometric composition is an oxide insulating film from which part of oxygen is released by heating.", "The oxide insulating film whose oxygen content is in excess of that in the stoichiometric composition is, similarly to the base insulating film 33 in Embodiment 2, an oxide insulating film in which the amount of released oxygen by conversion into oxygen atoms is greater than or equal to 1×1018 atoms/cm3, preferably greater than or equal to 3×1020 atoms/cm3 in TDS analysis.", "As the insulating film 24a, a silicon oxide film or a silicon oxynitride film can be formed under the following conditions: the substrate placed in a treatment chamber of the plasma CVD apparatus, which is vacuum-evacuated, is held at a temperature higher than or equal to 180° C. and lower than or equal to 400° C., preferably higher than or equal to 200° C. and lower than or equal to 370° C., the pressure in the treatment chamber is greater than or equal to 30 Pa and less than or equal to 250 Pa, preferably greater than or equal to 40 Pa and less than or equal to 200 Pa with introduction of a source gas into the treatment chamber, and high-frequency power is supplied to an electrode provided in the treatment chamber.", "Note that when the ratio of the amount of the oxidizing gas to the amount of the deposition gas containing silicon is 100 or higher, the hydrogen content in the insulating film 24a can be reduced.", "Consequently, the amount of hydrogen entering the insulating film 24a can be reduced; thus, the shift of the threshold voltage of the transistor in the negative direction can be suppressed.", "As the insulating film 24b, a silicon oxide film, a silicon oxynitride film, or the like having a thickness greater than or equal to 30 nm and less than or equal to 500 nm, preferably greater than or equal to 50 nm and less than or equal to 400 nm can be used.", "Further, it is preferable that the insulating film 24b have a few defects, and typically, the spin density of a signal at g=2.001 which is due to dangling bonds of silicon by ESR measurement be lower than or equal to 1×1018 spins/cm3.Note that the insulating film 24b is provided more apart from the oxide semiconductor film 19 than the insulating film 24a is; thus, the insulating film 24b may have more defect density than the insulating film 24a.", "As the insulating film 24b, a silicon oxide film or a silicon oxynitride film is formed under the following conditions: the substrate placed in a treatment chamber of the plasma CVD apparatus, which is vacuum-evacuated, is held at a temperature higher than or equal to 180° C. and lower than or equal to 260° C., preferably higher than or equal to 180° C. and lower than or equal to 240° C., the pressure is greater than or equal to 100 Pa and less than or equal to 250 Pa, preferably greater than or equal to 100 Pa and less than or equal to 200 Pa with introduction of a source gas into the treatment chamber, and high-frequency power higher than or equal to 0.17 W/cm2 and lower than or equal to 0.5 W/cm2, preferably higher than or equal to 0.25 W/cm2 and lower than or equal to 0.35 W/cm2 is supplied to an electrode provided in the treatment chamber.", "As the film formation conditions of the insulating film 24b, the high-frequency power having the above power density is supplied to the treatment chamber having the above pressure, whereby the degradation efficiency of the source gas in plasma is increased, oxygen radicals are increased, and oxidation of the source gas is promoted; therefore, the oxygen content of the insulating film 24b becomes higher than that in the stoichiometric composition.", "On the other hand, in the film formed at a substrate temperature within the above temperature range, the bonding strength between silicon and oxygen is weak, and accordingly, part of oxygen in the film is released by heating in the later step.", "Thus, it is possible to form an oxide insulating film whose oxygen content is in excess of that in the stoichiometric composition and from which part of oxygen is released by heating.", "Moreover, the insulating film 24a is provided over the oxide semiconductor film 19.In the formation step of the insulating film 24b, the insulating film 24a functions as a film which relieves damage to the oxide semiconductor film 19.Consequently, the insulating film 24b can be formed using the high-frequency power having a high power density while damage to the oxide semiconductor film 19 is reduced.", "When the insulating film 24b is formed over the insulating film 24a during heat treatment, oxygen is moved to the oxide semiconductor film 19 and oxygen vacancies in the oxide semiconductor film 19 can be compensated.", "Alternatively, when the insulating film 24b is formed over the insulating film 24a and is then subjected to heat treatment, oxygen is moved to the oxide semiconductor film 19 and oxygen vacancies in the oxide semiconductor film 19 can be compensated.", "Consequently, the amount of oxygen vacancies in the oxide semiconductor film can be reduced.", "When the oxide insulating film whose oxygen content is in excess of that in the stoichiometric composition is provided over a back channel of the oxide semiconductor film 19 (a surface of the oxide semiconductor film 19, which is opposite to a surface facing the gate electrode 15) with the oxide insulating film which transmits oxygen provided therebetween, oxygen can be moved to the back channel side of the oxide semiconductor film 19, and oxygen vacancies on the back channel side can be reduced.", "In the formation step of the insulating film 24b, in the case where the oxide semiconductor film 19 is not damaged, the insulating film 24a is not necessarily provided and only the insulating film 24b which is an oxide insulating film whose oxygen content is in excess of that in the stoichiometric composition may be provided as a protective film.", "The nitride insulating film 25 is formed over the insulating film 24b.", "By providing the nitride insulating film 25, the amount of hydrogen and ammonia which are moved from the nitride insulating film to the oxide semiconductor film 19 is small and the concentration of hydrogen and nitrogen in the oxide semiconductor film 19 can be reduced.", "Further, the nitride insulating film 25 is provided over the transistor 7, whereby entry of water from the outside to the oxide semiconductor film 19 can be suppressed.", "In other words, entry of hydrogen contained in water to the oxide semiconductor film 19 can be suppressed.", "It is preferable that a blocking property of the nitride insulating film 25 against oxygen be high because the movement of oxygen contained in the insulating film 24b to the outside can be suppressed and oxygen contained in the insulating film 24b can be moved to the oxide semiconductor film 19.As a result, a shift of the threshold voltage in the negative direction can be suppressed and variation in electrical characteristics can be reduced.", "Further, leakage current between a source and a drain of the transistor, typically off-state current, can be reduced.", "In addition, a change in electrical characteristics due to a change over time or a BT photostress test can be suppressed.", "For the planarization film 27, an organic material, such as acrylic resin, epoxy resin, benzocyclobutene resin, polyimide, polyamide, or the like can be used.", "Other than such organic materials, it is possible to use a silicone resin or the like.", "Note that the planarization film may be formed by stacking a plurality of insulating films formed using these materials.", "The organic material used for the planarization film 27 contains much water or gas than an inorganic insulating film, and the water and the gas are moved to the oxide semiconductor film by heat treatment in some cases.", "Further, the organic material easily transmits water from the outside.", "Therefore the planarization film 27 is formed, whereby electrical characteristics in a transistor including the oxide semiconductor film are changed by the water or gas, and the reliability of the transistor may be decreased.", "Thus, like the transistor 7 in FIGS.", "6A and 6B, the nitride insulating film 25 which has a function of suppressing entry of water is preferably provided between the transistor 7 and the planarization film 27.Further, the nitride insulating film 25 is preferably provided between the insulating film 24b and the planarization film 27 because the adhesion between the nitride insulating film 25 and the planarization film 27 is improved.", "For the conductive film 29, the material used for the pair of electrodes 21 can be used as appropriate.", "As the conductive film 29, a conductive material having a light-transmitting property can be used, such as indium oxide which includes tungsten oxide, indium zinc oxide which includes tungsten oxide, indium oxide which includes titanium oxide, indium tin oxide which includes titanium oxide, indium tin oxide (hereinafter referred to as ITO), indium zinc oxide, or indium tin oxide which includes silicon oxide.", "As the gate insulating film 18, an oxide insulating film whose oxygen content is in excess of that in the stoichiometric composition may be used.", "An oxide insulating film whose oxygen content is in excess of that in the stoichiometric composition is used as the gate insulating film 18, whereby the interface state between the oxide semiconductor film 19 and the gate insulating film 18 can be reduced, a shift of the threshold voltage in the negative direction can be suppressed, and variation in electrical characteristics of the transistor can be reduced.", "After the formation step of the pair of electrodes 21 over the oxide semiconductor film 19 illustrated in FIG.", "2C of Embodiment 1, an oxide semiconductor film having few oxygen vacancies may be formed by exposing the oxide semiconductor film 19 to plasma generated in an oxygen atmosphere and supplying oxygen to the oxide semiconductor film 19.Atmospheres of oxygen, ozone, dinitrogen monoxide, nitrogen dioxide, and the like can be given as examples of oxygen atmospheres.", "Further, in the plasma treatment, the oxide semiconductor film 19 is preferred to be exposed to plasma generated with no bias applied to the substrate 11 side.", "Consequently, the oxide semiconductor film 19 can be supplied with oxygen without being damaged; accordingly, the amount of oxygen vacancies in the oxide semiconductor film 19 can be reduced.", "Moreover, impurities remaining on the surface of the oxide semiconductor film 19 due to the etching treatment for forming the pair of electrodes 21, for example, a halogen such as fluorine or chlorine can be removed.", "Through the above-described steps, a transistor with the improved reliability, in which a change in electrical characteristics is suppressed, can be manufactured.", "Further, a transistor in which a change in electrical characteristics due to a change over time or a BT photostress test is small can be manufactured.", "Typically a transistor with the high reliability, in which variation in threshold voltage is small, can be manufactured.", "Note that the structures, methods, and the like described in this embodiment can be used as appropriate in combination with any of the structures, methods, and the like described in the other embodiments and examples.", "Embodiment 5 In this embodiment, a structure of a gate insulating film which is different from that in Embodiment 2 will be described with reference to FIGS.", "7A and 7B.", "FIGS.", "7A and 7B are a top view and a cross-sectional view of a transistor 9 included in a semiconductor device.", "FIG.", "7A is a top view of the transistor 9, and FIG.", "7B is a cross-sectional view taken along dashed line A-B in FIG.", "7A.", "Note that in FIG.", "7A, the substrate 31, the base insulating film 33, some components of the transistor 9 (e.g., an insulating film 38a, an insulating film 38b, and the nitride insulating film 39), a planarization film 43, and the like are omitted for simplicity.", "The transistor 9 illustrated in FIGS.", "7A and 7B includes the oxide semiconductor film 34 formed over the base insulating film 33 and the pair of electrodes 35 in contact with the oxide semiconductor film 34.Further, the transistor 9 includes a gate insulating film 42 including the insulating film 38a, the insulating film 38b, and the nitride insulating film 39, and a gate electrode 41 overlapping with the oxide semiconductor film 34 with the gate insulating film 42 provided therebetween.", "A planarization film 43 covering the gate insulating film 42 and the gate electrode 41 may be included.", "Moreover, a conductive film 45, which is in contact with one of the pair of electrodes 35 through an opening 47 provided in the gate insulating film 42 and the planarization film 43, may be included.", "In the transistor 9 shown in this embodiment, the insulating film 38a is formed in contact with the oxide semiconductor film 34.The insulating film 38a is an oxide insulating film which transmits oxygen.", "As the insulating film 38a, the insulating film 24a in Embodiment 4 can be used as appropriate.", "By forming the oxide insulating film which transmits oxygen as the insulating film 38a, oxygen released from the oxide insulating film provided over the insulating film 38a, whose oxygen content is in excess of that in the stoichiometric composition, can be moved to the oxide semiconductor film 34 through the insulating film 38a.", "The insulating film 38b is formed to be in contact with the insulating film 38a.", "The insulating film 38b is an oxide insulating film whose oxygen content is in excess of that in the stoichiometric composition.", "As the insulating film 38b, the insulating film 24b in Embodiment 4 can be used as appropriate.", "When the insulating film 38b is formed over the insulating film 38a during heat treatment, oxygen is moved to the oxide semiconductor film 34 and oxygen vacancies in the oxide semiconductor film 34 can be compensated.", "Alternatively, when the insulating film 38b is formed over the insulating film 38a and is then subjected to heat treatment, oxygen is moved to the oxide semiconductor film 34 and oxygen vacancies in the oxide semiconductor film 34 can be compensated.", "Consequently, the amount of oxygen vacancies in the oxide semiconductor film can be reduced.", "As the gate insulating film, an insulating film having few defects is used, whereby a shift of the threshold voltage in the negative direction can be suppressed and variation in electrical characteristics of the transistor can be reduced.", "In the formation step of the insulating film 38b, in the case where the oxide semiconductor film 34 is not damaged, the insulating film 38a is not necessarily provided and only the insulating film 38b which is an oxide insulating film from which part of oxygen is released by heating may be provided.", "The nitride insulating film 39 is formed over the insulating film 38b.", "By providing the nitride insulating film 39, the amount of hydrogen and ammonia which are moved from the nitride insulating film to the oxide semiconductor film 34 is small and the concentration of hydrogen and nitrogen in the oxide semiconductor film 34 can be reduced.", "Further, the nitride insulating film 39 is provided over the transistor 9, whereby entry of water from the outside to the oxide semiconductor film 34 can be suppressed.", "In other words, entry of hydrogen contained in water to the oxide semiconductor film 34 can be suppressed.", "It is preferable that a blocking property of the nitride insulating film 39 against oxygen be high because the movement of oxygen contained in the insulating film 38b to the outside can be suppressed and oxygen contained in the insulating film 38b can be moved to the oxide semiconductor film 34.As a result, a shift of the threshold voltage in the negative direction can be suppressed and variation in electrical characteristics can be reduced.", "Further, leakage current between a source and a drain of the transistor, typically off-state current, can be reduced.", "In addition, a change in electrical characteristics due to a change over time or a BT photostress test can be suppressed.", "The planarization film 43 can be formed using the material of the planarization film 27, which is described in Embodiment 4, as appropriate.", "Note that the nitride insulating film 39 is preferably provided between the insulating film 38b and the planarization film 43 because the adhesion between the nitride insulating film 39 and the planarization film 43 is improved.", "For the conductive film 45, the material of the conductive film 29, which is described in Embodiment 4, can be used as appropriate.", "As in Embodiment 4, in this embodiment, after the formation step of the pair of electrodes 35 over the oxide semiconductor film 34 illustrated in FIG.", "4B of Embodiment 2, an oxide semiconductor film having few oxygen vacancies may be formed by exposing the oxide semiconductor film 34 to plasma generated in an oxygen atmosphere and supplying oxygen to the oxide semiconductor film 34.Consequently, the oxide semiconductor film 34 can be supplied with oxygen without being damaged; accordingly, the amount of oxygen vacancies in the oxide semiconductor film 34 can be reduced.", "Through the above-described steps, a transistor with the improved reliability, in which a change in electrical characteristics is suppressed, can be manufactured.", "Further, a transistor in which a change in electrical characteristics due to a change over time or a BT photostress test is small can be manufactured.", "Typically a transistor with the high reliability, in which variation in threshold voltage is small, can be manufactured.", "Note that the structures, methods, and the like described in this embodiment can be used as appropriate in combination with any of the structures, methods, and the like described in the other embodiments and examples.", "Embodiment 6 A semiconductor device (also referred to as a display device) having a display function can be manufactured using the transistor examples of which are shown in the above embodiments.", "Moreover, some or all of the driver circuits which include the transistor can be formed over a substrate where the pixel portion is formed, whereby a system-on-panel can be obtained.", "In this embodiment, an example of a display device using the transistor examples of which are shown in the above embodiments is described with reference to FIGS.", "8A to 8C, FIGS.", "9A and 9B, FIG.", "10, and FIGS.", "11A to 11C.", "FIGS.", "9A, 9B, and FIG.", "10 are cross-sectional views illustrating cross-sectional structures taken along chain line M-N in FIG.", "8B.", "In FIG.", "8A, a sealant 905 is provided so as to surround a pixel portion 902 provided over a first substrate 901, and the pixel portion 902 is sealed with a second substrate 906.In FIG.", "8A, a signal line driver circuit 903 and a scan line driver circuit 904 each are formed using a single crystal semiconductor or a polycrystalline semiconductor over a substrate prepared separately, and mounted in a region different from the region surrounded by the sealant 905 over the first substrate 901.Further, various signals and potentials are supplied to the signal line driver circuit 903, the scan line driver circuit 904, and the pixel portion 902 from flexible printed circuits (FPCs) 918a and 918b.", "In FIGS.", "8B and 8C, the sealant 905 is provided so as to surround the pixel portion 902 and the scan line driver circuit 904 which are provided over the first substrate 901.The second substrate 906 is provided over the pixel portion 902 and the scan line driver circuit 904.Thus, the pixel portion 902 and the scan line driver circuit 904 are sealed together with a display element by the first substrate 901, the sealant 905, and the second substrate 906.In FIGS.", "8B and 8C, a signal line driver circuit 903 which is formed using a single crystal semiconductor or a polycrystalline semiconductor over a substrate separately prepared is mounted in a region different from the region surrounded by the sealant 905 over the first substrate 901.In FIGS.", "8B and 8C, various signals and potentials are supplied to the signal line driver circuit 903, the scan line driver circuit 904, and the pixel portion 902 from an FPC 918.Although FIGS.", "8B and 8C each show an example in which the signal line driver circuit 903 is formed separately and mounted on the first substrate 901, one embodiment of the present invention is not limited to this structure.", "The scan line driver circuit may be separately formed and then mounted, or only part of the signal line driver circuit or part of the scan line driver circuit may be separately formed and then mounted.", "Note that a connection method of a separately formed driver circuit is not particularly limited, and a chip on glass (COG) method, a wire bonding method, a tape automated bonding (TAB) method, or the like can be used.", "FIG.", "8A shows an example in which the signal line driver circuit 903 and the scan line driver circuit 904 are mounted by a COG method.", "FIG.", "8B shows an example in which the signal line driver circuit 903 is mounted by a COG method.", "FIG.", "8C shows an example in which the signal line driver circuit 903 is mounted by a TAB method.", "The display device includes in its category a panel in which a display element is sealed and a module in which an IC including a controller or the like is mounted on the panel.", "A display device in this specification refers to an image display device, a display device, or a light source (including a lighting device).", "Further, the display device also includes the following modules in its category: a module to which a connector such as an FPC or a TCP is attached; a module having a TCP at the tip of which a printed wiring board is provided; and a module in which an integrated circuit (IC) is directly mounted on a display element by a COG method.", "The pixel portion and the scan line driver circuit provided over the first substrate include a plurality of transistors and any of the transistors which are described in the above embodiments can be used.", "As the display element provided in the display device, a liquid crystal element (also referred to as a liquid crystal display element) or a light-emitting element (also referred to as a light-emitting display element) can be used.", "A light emitting element includes, in its scope, an element whose luminance is controlled by current or voltage, and specifically includes an inorganic electroluminescent (EL) element, an organic EL element, and the like.", "Further, a display medium whose contrast is changed by an electric effect, such as electronic ink, can be used.", "A light-emitting device shown in FIG.", "9A includes a connection terminal electrode 915 and a terminal electrode 916.The connection terminal electrode 915 and the terminal electrode 916 are electrically connected to a terminal included in the FPC 918 through an anisotropic conductive agent 919.The connection terminal electrode 915 is formed using the same conductive film as a first electrode 930, and the terminal electrode 916 is formed using the same conductive film as a pair of electrodes in each of a transistor 910 and a transistor 911.A light-emitting device shown in FIG.", "9B includes a connection terminal electrodes 915a, 915b, and a terminal electrode 916.The connection terminal electrodes 915a, 915b, and the terminal electrode 916 are electrically connected to a terminal included in the FPC 918 through an anisotropic conductive agent 919.The connection terminal electrode 915a is formed using the same conductive film as a first electrode 930, the connection terminal electrode 915b is formed using the same conductive film as a second electrode 941, and the terminal electrode 916 is formed using the same conductive film as a pair of electrodes in each of a transistor 910 and a transistor 911.Further, as illustrated in FIG.", "10, the semiconductor device includes a connection terminal electrode 955 and a terminal electrode 916.The connection terminal electrode 955 and the terminal electrode 916 are electrically connected to a terminal included in the FPC 918 through an anisotropic conductive agent 919.The connection terminal electrode 955 is formed using the same conductive film as a second electrode 951, and the terminal electrode 916 is formed using the same conductive film as a pair of electrodes in each of a transistor 910 and a transistor 911.Each of the pixel portion 902 and the scan line driver circuit 904 which are provided over the first substrate 901 includes a plurality of transistors.", "FIGS.", "9A, 9B, and FIG.", "10 illustrate the transistor 910 included in the pixel portion 902 and the transistor 911 included in the scan line driver circuit 904.In FIG.", "9A, the protective film 26 described in Embodiment 1 or an insulating film 924 corresponding to the protective film 28 in Embodiment 4 is provided over the transistor 910 and the transistor 911.In FIG.", "9B, a planarization film 921 is further provided over the insulating film 924.Note that an insulating film 923 serves as a base film.", "In this embodiment, any of the transistors described in the above embodiments can be used as the transistor 910 and the transistor 911.Moreover, FIG.", "10 shows an example in which a conductive film 917 is provided over the insulating film 924 so as to overlap with a channel formation region of the oxide semiconductor film of the transistor 911 for the driver circuit.", "In this embodiment, the conductive film 917 is formed using the same conductive film as the first electrode 930.By providing the conductive film 917 so as to overlap with the channel formation region of the oxide semiconductor film, the amount of change in the threshold voltage of the transistor 911 between before and after a BT stress test can be further reduced.", "The conductive film 917 may have the same potential as or a potential different from that of the gate electrode of the transistor 911, and the conductive film 917 can serve as a second gate electrode.", "The potential of the conductive film 917 may be GND, 0 V or in a floating state.", "In addition, the conductive film 917 has a function of blocking an external electric field.", "In other words, the conductive film 917 has a function of preventing an external electric field (particularly, a function of preventing static electricity) from affecting the inside (a circuit portion including the transistor).", "Such a blocking function of the conductive film 917 can prevent a change in electrical characteristics of the transistor due to the influence of an external electric field such as static electricity.", "The conductive film 917 can be used for any of the transistors described in the above embodiments.", "In the display panel, the transistor 910 included in the pixel portion 902 is electrically connected to a display element.", "There is no particular limitation on the kind of the display element as long as display can be performed, and various kinds of display elements can be used.", "The first electrode and the second electrode (each of which may be called a pixel electrode, a common electrode, a counter electrode, or the like) for applying voltage to the display element may have light-transmitting properties or light-reflecting properties, which depends on the direction in which light is extracted, the position where the electrode is provided, and the pattern structure of the electrode.", "The first electrode 930, the second electrode 931, and the second electrode 941 can be formed using a light-transmitting conductive material such as indium oxide including tungsten oxide, indium zinc oxide including tungsten oxide, indium oxide including titanium oxide, indium tin oxide including titanium oxide, indium tin oxide (hereinafter referred to as ITO), indium zinc oxide, or indium tin oxide to which silicon oxide is added.", "Alternatively, the first electrode 930, the second electrode 931, and the second electrode 941 can be formed using one or more materials selected from metals such as tungsten (W), molybdenum (Mo), zirconium (Zr), hafnium (Hf), vanadium (V), niobium (Nb), tantalum (Ta), chromium (Cr), cobalt (Co), nickel (Ni), titanium (Ti), platinum (Pt), aluminum (Al), copper (Cu), and silver (Ag); an alloy of any of these metals; and a nitride of any of these metals.", "The first electrode 930, the second electrode 931, and the second electrode 941 can be formed using a conductive composition including a conductive macromolecule (also referred to as a conductive polymer).", "As the conductive high molecule, what is called a π-electron conjugated conductive polymer can be used.", "For example, polyaniline or a derivative thereof, polypyrrole or a derivative thereof, polythiophene or a derivative thereof, a copolymer of two or more of aniline, pyrrole, and thiophene or a derivative thereof, and the like can be given.", "An example of a liquid crystal display device using a liquid crystal element as a display element is illustrated in FIGS.", "9A and 9B.", "FIG.", "9A illustrates an example in which a vertical electric field method is employed.", "In FIG.", "9A, a liquid crystal element 913 which is a display element includes the first electrode 930, a second electrode 931, and a liquid crystal layer 908.Note that an insulating film 932 and an insulating film 933 which serve as alignment films are provided so that the liquid crystal layer 908 is provided therebetween.", "The second electrode 931 is provided on the second substrate 906 side.", "The second electrode 931 overlaps with the first electrode 930 with the liquid crystal layer 908 provided therebetween.", "FIG.", "9B illustrates an example in which a fringe field switching (FFS) mode, which is one of horizontal electric field modes, is employed.", "In FIG.", "9B, a liquid crystal element 943 which is a display element includes the first electrode 930, the second electrode 941, and the liquid crystal layer 908 which are formed over the planarization film 921.The second electrode 941 functions as the common electrode.", "An insulating film 944 is provided between the first electrode 930 and the second electrode 941.The insulating film 944 is formed using a silicon nitride film.", "An insulating film 932 and an insulating film 933 which serve as alignment films are provided so that the liquid crystal layer 908 is interposed therebetween.", "A spacer 935 is a columnar spacer obtained by selective etching of an insulating film and is provided in order to control the distance between the first electrode 930 and the second electrode 931 (a cell gap).", "Alternatively, a spherical spacer may be used.", "In the case where a liquid crystal element is used as the display element, a thermotropic liquid crystal, a low-molecular liquid crystal, a high-molecular liquid crystal, a polymer-dispersed liquid crystal, a ferroelectric liquid crystal, an anti-ferroelectric liquid crystal, or the like can be used.", "Such a liquid crystal material exhibits a cholesteric phase, a smectic phase, a cubic phase, a chiral nematic phase, an isotropic phase, or the like depending on a condition.", "Alternatively, a liquid crystal exhibiting a blue phase for which an alignment film is unnecessary may be used.", "A blue phase is one of liquid crystal phases, which is generated just before a cholesteric phase changes into an isotropic phase while temperature of cholesteric liquid crystal is raised.", "Since the blue phase appears only in a narrow temperature range, a liquid crystal composition in which a chiral material is mixed is used for the liquid crystal layer in order to improve the temperature range.", "The liquid crystal composition which includes a liquid crystal showing a blue phase and a chiral agent has a short response time of 1 msec or less, and has optical isotropy, which makes the alignment process unneeded and viewing angle dependence small.", "In addition, since an alignment film does not need to be provided and rubbing treatment is unnecessary, electrostatic discharge damage caused by the rubbing treatment can be prevented and defects and damage of the liquid crystal display device in the manufacturing process can be reduced.", "Thus, the productivity of the liquid crystal display device can be increased.", "The first substrate 901 and the second substrate 906 are fixed in place by the sealant 925.As the sealant 925, an organic resin such as a thermosetting resin or a photocurable resin can be used.", "In the liquid crystal display device in FIG.", "9A, the sealant 925 is in contact with a gate insulating film 922, and the planarization film 921 is provided on an inner side than the sealant 925.Note that the gate insulating film 922 is formed by stacking a silicon nitride film and a silicon oxynitride film.", "Further, when the insulating film 924 is selectively etched, it is preferable that the silicon nitride film be exposed by etching the silicon oxynitride film in the upper layer of the gate insulating film 922.As a result, the sealant 925 is in contact with the silicon nitride film formed in the gate insulating film 922, and entry of water from the outside into the sealant 925 can be suppressed.", "In the liquid crystal display device in FIG.", "9B, the sealant 925 is in contact with the insulating film 924.The planarization film 921 is provided on an inner side than the sealant 925 and the sealant 925 is in contact with the silicon nitride film on the surface of the insulating film 924; thus, entry of water from the outside into the sealant 925 can be suppressed.", "The size of storage capacitor formed in the liquid crystal display device is set considering the leakage current of the transistor provided in the pixel portion or the like so that charge can be held for a predetermined period.", "By using the transistor including the highly-purified oxide semiconductor film, it is enough to provide a storage capacitor having a capacitance that is ⅓ or less, preferably ⅕ or less of a liquid crystal capacitance of each pixel; therefore, the aperture ratio of a pixel can be increased.", "In the display device, a black matrix (a light-blocking film), an optical member (an optical substrate) such as a polarizing member, a retardation member, or an anti-reflection member, and the like are provided as appropriate.", "For example, circular polarization may be obtained by using a polarizing substrate and a retardation substrate.", "In addition, a backlight, a side light, or the like may be used as a light source.", "As a display method in the pixel portion, a progressive method, an interlace method, or the like can be used.", "Further, color elements controlled in a pixel at the time of color display are not limited to three colors: R, G, and B (R, G, and B correspond to red, green, and blue, respectively).", "For example, R, G, B, and W (W corresponds to white), or R, G, B, and one or more of yellow, cyan, magenta, and the like can be used.", "Further, the sizes of display regions may be different between respective dots of color elements.", "The present invention is not limited to the application to a display device for color display but can also be applied to a display device for monochrome display.", "FIGS.", "11A to 11C illustrate an example of the display device in FIG.", "9A in which a common connection portion (pad portion) for electrically connecting to the second electrode 931 provided on the second substrate 906 is formed over the first substrate 901.Note that the contact hole in the pixel portion and the openings in the common connection portion are distinctively described because their sizes differ considerably.", "In FIGS.", "9A and 9B and FIGS.", "11A to 11C, the pixel portion 902 and the common connection portion are not illustrated on the same scale.", "For example, the length of the chain line I-J in the common connection portion is about 500 μm, whereas the size of the transistor of the pixel portion 902 is less than 50 μm; thus, the area of the common connection portion is ten times or more as large as that of the transistor.", "However, the scales of the pixel portion 902 and the common connection portion are changed in FIGS.", "9A and 9B and FIGS.", "11A to 11C for simplification.", "The common connection portion is provided in a position that overlaps with the sealant for bonding the first substrate 901 and the second substrate 906, and is electrically connected to the second electrode 931 through conductive particles contained in the sealant.", "Alternatively, the common connection portion is provided in a position that does not overlap with the sealant (except for the pixel portion) and a paste containing conductive particles is provided separately from the sealant so as to overlap with the common connection portion, whereby the common connection portion is electrically connected to the second electrode 931.FIG.", "11A is a cross-sectional view of the common connection portion taken along a line I-J in the top view in FIG.", "11B.", "A common potential line 975 is provided over the gate insulating film 922 and is formed using the same material and through the same steps as the source electrode 971 or the drain electrode 973 of the transistor 910 illustrated in FIGS.", "9A and 9B.", "Further, the common potential line 975 is covered with the insulating film 924 and the planarization film 921, and a plurality of openings is included in the insulating film 924 and the planarization film 921 at a position overlapping with the common potential line 975.These openings are formed through the same steps as a contact hole which connects the first electrode 930 and one of the source electrode 971 and the drain electrode 973 of the transistor 910.Further, the common potential line 975 is connected to the common electrode 977 through the opening.", "The common electrode 977 is provided over the planarization film 921 and formed using the same material and through the same steps as the connection terminal electrode 915 and the first electrode 930 in the pixel portion.", "In this manner, the common connection portion can be manufactured in the same process as the switching element in the pixel portion 902.The common electrode 977 is an electrode in contact with the conductive particles contained in the sealant, and is electrically connected to the second electrode 931 of the second substrate 906.Alternatively, as illustrated in FIG.", "11C, a common potential line 985 may be formed using the same material and through the same steps as the gate electrode of the transistor 910.In the common connection portion in FIG.", "11C, the common potential line 985 is provided under the gate insulating film 922, the insulating film 924, and the planarization film 921, and a plurality of openings is included in the gate insulating film 922, the insulating film 924, and the planarization film 921 at a position overlapping with the common potential line 985.These openings are formed by etching the insulating film 924 and the planarization film 921 and further selectively etching the gate insulating film 922, which are the same steps as a contact hole which connects the first electrode 930 and one of the source electrode 971 and the drain electrode 973 of the transistor 910.Further, the common potential line 985 is connected to the common electrode 987 in the opening portion.", "The common electrode 987 is provided over the planarization film 921 and formed using the same material and through the same steps as the connection terminal electrode 915 and the first electrode 930 in the pixel portion.", "Note that in the liquid crystal display device of an FFS mode in FIG.", "9B, the common electrodes 977 and 987 are each connected to the second electrode 941.Next, as the display element included in the display device, a light-emitting element utilizing electroluminescence can be used.", "Light-emitting elements utilizing electroluminescence are classified according to whether a light-emitting material is an organic compound or an inorganic compound.", "In general, the former is referred to as an organic EL element, and the latter is referred to as an inorganic EL element.", "In the organic EL element, by application of voltage to a light-emitting element, electrons and holes are separately injected from a pair of electrodes into a layer containing a light-emitting organic compound, and current flows.", "The carriers (electrons and holes) are recombined, and thus, the light-emitting organic compound is excited.", "The light-emitting organic compound returns to a ground state from the excited state, thereby emitting light.", "Owing to such a mechanism, this light-emitting element is referred to as a current-excitation light-emitting element.", "The inorganic EL elements are classified according to their element structures into a dispersion-type inorganic EL element and a thin-film inorganic EL element.", "The dispersion-type inorganic EL element has a light-emitting layer where particles of a light-emitting material are dispersed in a binder, and its light emission mechanism is donor-acceptor recombination type light emission that utilizes a donor level and an acceptor level.", "The thin-film inorganic EL element has a structure where a light-emitting layer is sandwiched between dielectric layers, which are further sandwiched between electrodes, and its light emission mechanism is localized type light emission that utilizes inner-shell electron transition of metal ions.", "Note that an example of an organic EL element as a light-emitting element is described here.", "In order to extract light emitted from the light-emitting element, it is acceptable as long as at least one of a pair of electrodes is transparent.", "A transistor and a light-emitting element are formed over a substrate.", "The light-emitting element can have a top emission structure in which light emission is extracted through the surface opposite to the substrate; a bottom emission structure in which light emission is extracted through the surface on the substrate side; or a dual emission structure in which light emission is extracted through the surface opposite to the substrate and the surface on the substrate side, and a light-emitting element having any of these emission structures can be used.", "An example of a light-emitting device using a light-emitting element as the display element is shown in FIG.", "10.A light-emitting element 963 which is a display element is electrically connected to the transistor 910 provided in the pixel portion 902.Note that although the structure of the light-emitting element 963 is a stacked-layer structure of the first electrode 930, a light-emitting layer 961, and the second electrode 931, the structure is not limited thereto.", "The structure of the light-emitting element 963 can be changed as appropriate depending on the direction in which light is extracted from the light-emitting element 963, or the like.", "A silicon nitride film 950 is provided between the planarization film 921 and the first electrode 930.The silicon nitride film 950 is in contact with side surfaces of the planarization film 921 and the insulating film 924.A partition wall 960 is provided over end portions of the silicon nitride film 950 and the first electrode 930.A partition wall 960 can be formed using an organic insulating material or an inorganic insulating material.", "It is particularly preferred that the partition wall 960 be formed using a photosensitive resin material to have an opening over the first electrode 930 so that a sidewall of the opening has an inclined surface with a continuous curvature.", "The light-emitting layer 961 may be formed to have a single-layer structure or a stacked-layer structure including a plurality of layers.", "A protective layer may be formed over the second electrode 931 and the partition wall 960 in order to prevent oxygen, hydrogen, moisture, carbon dioxide, or the like from entering the light-emitting element 963.As the protective layer, a silicon nitride film, a silicon nitride oxide film, an aluminum oxide film, an aluminum nitride film, an aluminum oxynitride film, an aluminum nitride oxide film, a DLC film, or the like can be formed.", "In addition, in a space which is sealed with the first substrate 901, the second substrate 906, and a sealant 936, a filler 964 is provided and sealed.", "It is preferred that, in this manner, the light-emitting element be packaged (sealed) with a protective film (such as a laminate film or an ultraviolet curable resin film) or a cover material with high air-tightness and little degasification so that the panel is not exposed to the outside air.", "As the sealant 936, an organic resin such as a thermosetting resin or a photocurable resin, fitted glass including low-melting glass, or the like can be used.", "The fritted glass is preferred because of its high barrier property against impurities such as water and oxygen.", "Further, in the case where the fritted glass is used as the sealant 936, as illustrated in FIG.", "10, the fitted glass is provided over the silicon nitride film 950, whereby adhesion of the silicon nitride film 950 to the fritted glass becomes high and entry of water from the outside into the sealant 936 can be prevented.", "As the filler 964, as well as an inert gas such as nitrogen or argon, an ultraviolet curable resin or a thermosetting resin can be used: polyvinyl chloride (PVC), an acrylic resin, polyimide, an epoxy resin, a silicone resin, polyvinyl butyral (PVB), ethylene vinyl acetate (EVA), or the like can be used.", "For example, nitrogen is used for the filler.", "If necessary, an optical film such as a polarizing plate, a circularly polarizing plate (including an elliptically polarizing plate), a retardation plate (a quarter-wave plate or a half-wave plate), or a color filter may be provided as appropriate for a light-emitting surface of the light-emitting element.", "Further, a polarizing plate or a circularly polarizing plate may be provided with an anti-reflection film.", "For example, anti-glare treatment by which reflected light can be diffused by projections and depressions on the surface so as to reduce the glare can be performed.", "Further, an electronic paper in which electronic ink is driven can be provided as the display device.", "The electronic paper is also referred to as an electrophoretic display device (an electrophoretic display) and is advantageous in that it has the same level of readability as plain paper, it has lower power consumption than other display devices, and it can be made thin and lightweight.", "Since the transistor is easily broken owing to static electricity or the like, a protective circuit for protecting the driver circuit is preferred to be provided.", "The protection circuit is preferred to be formed using a nonlinear element.", "As described above, by using any of the transistors described in the above embodiments, a highly reliable semiconductor device having a display function can be provided.", "This embodiment can be implemented in appropriate combination with the structures described in the other embodiments.", "Embodiment 7 A semiconductor device having an image sensor function for reading data of an object can be formed with the use of the transistor described in any of Embodiments 1 to 6.An example of a semiconductor device having an image sensor function is illustrated in FIG.", "12A.", "FIG.", "12A illustrates an equivalent circuit of a photo sensor, and FIG.", "12B is a cross-sectional view illustrating part of the photo sensor.", "In a photodiode 602, one electrode is electrically connected to a photodiode reset signal line 658, and the other electrode is electrically connected to a gate of a transistor 640.One of a source and a drain of the transistor 640 is electrically connected to a photo sensor reference signal line 672, and the other of the source and the drain thereof is electrically connected to one of a source and a drain of a transistor 656.A gate of the transistor 656 is electrically connected to a gate signal line 659, and the other of the source and the drain thereof is electrically connected to a photo sensor output signal line 671.Note that in circuit diagrams in this specification, a transistor including an oxide semiconductor film is denoted by a symbol “OS” so that it can be identified as a transistor including an oxide semiconductor film.", "In FIG.", "12A, the transistor 640 and the transistor 656 are each a transistor including an oxide semiconductor film, to which the transistor described in any of Embodiments 1 to 6 can be applied.", "In this embodiment, an example in which a transistor having a structure similar to that of the transistor 7 described in Embodiment 4 is applied is described.", "FIG.", "12B is a cross-sectional view of the photodiode 602 and the transistor 640 in the photosensor.", "The transistor 640 and the photodiode 602 functioning as a sensor are provided over a substrate 601 (an element substrate) having an insulating surface.", "A substrate 613 is provided over the photodiode 602 and the transistor 640 with an adhesive layer 608 interposed therebetween.", "An insulating film 632, a planarization film 633, and a planarization film 634 are provided over the transistor 640.The photodiode 602 includes an electrode 641b formed over the planarization film 633; a first semiconductor film 606a, a second semiconductor film 606b, and a third semiconductor film 606c over the electrode 641b in this order; an electrode 642 which is provided over the planarization film 634 and electrically connected to the electrode 641b through the first to third semiconductor films; and an electrode 641a which is provided in the same layer as the electrode 641b and electrically connected to the electrode 642.The electrode 641b is electrically connected to a conductive layer 643 formed over the planarization film 634, and the electrode 642 is electrically connected to a conductive film 645 through the electrode 641a.", "The conductive film 645 is electrically connected to a gate electrode of the transistor 640, and thus the photodiode 602 is electrically connected to the transistor 640.Here, a pin photodiode in which a semiconductor film having p-type conductivity type as the first semiconductor film 606a, a high-resistance semiconductor film (i-type semiconductor film) as the second semiconductor film 606b, and a semiconductor film having n-type conductivity type as the third semiconductor film 606c are stacked is illustrated as an example.", "The first semiconductor film 606a is a p-type semiconductor film and can be formed using an amorphous silicon film containing an impurity element imparting p-type conductivity.", "The first semiconductor film 606a is formed by a plasma CVD method with the use of a semiconductor source gas containing an impurity element belonging to Group 13 (e.g., boron (B)).", "As the semiconductor material gas, silane (SiH4) may be used.", "Alternatively, Si2H6, SiH2Cl2, SiHCl3, SiCl4, SiF4, or the like may be used.", "Further alternatively, an amorphous silicon film which does not contain an impurity element may be formed, and then, an impurity element may be introduced to the amorphous silicon film with use of a diffusion method or an ion injecting method.", "Heating or the like may be conducted after introducing the impurity element by an ion implantation method or the like in order to diffuse the impurity element.", "In that case, as a method of forming the amorphous silicon film, an LPCVD method, a chemical vapor deposition method, a sputtering method, or the like may be used.", "The first semiconductor film 606a is preferably formed to a thickness greater than or equal to 10 nm and less than or equal to 50 nm.", "The second semiconductor film 606b is an i-type semiconductor film (intrinsic semiconductor film) and is formed using an amorphous silicon film.", "As for formation of the second semiconductor film 606b, an amorphous silicon film is formed by a plasma CVD method with the use of a semiconductor source gas.", "As the semiconductor material gas, silane (SiH4) may be used.", "Alternatively, Si2H6, SiH2Cl2, SiHCl3, SiCl4, SiF4, or the like may be used.", "The second semiconductor film 606b may be formed by an LPCVD method, a vapor deposition method, a sputtering method, or the like.", "The second semiconductor film 606b is preferably formed to have a thickness greater than or equal to 200 nm and less than or equal to 1000 nm.", "The third semiconductor film 606c is an n-type semiconductor film and is formed using an amorphous silicon film containing an impurity element imparting n-type conductivity.", "The third semiconductor film 606c is formed by a plasma CVD method with the use of a semiconductor source gas containing an impurity element belonging to Group 15 (e.g., phosphorus (P)).", "As the semiconductor material gas, silane (SiH4) may be used.", "Alternatively, Si2H6, SiH2Cl2, SiHCl3, SiCl4, SiF4, or the like may be used.", "Further alternatively, an amorphous silicon film which does not contain an impurity element may be formed, and then, an impurity element may be introduced to the amorphous silicon film with use of a diffusion method or an ion injecting method.", "Heating or the like may be conducted after introducing the impurity element by an ion implantation method or the like in order to diffuse the impurity element.", "In that case, as a method of forming the amorphous silicon film, an LPCVD method, a chemical vapor deposition method, a sputtering method, or the like may be used.", "The third semiconductor film 606c is preferably formed to have a thickness greater than or equal to 20 nm and less than or equal to 200 nm.", "The first semiconductor film 606a, the second semiconductor film 606b, and the third semiconductor film 606c are not necessarily formed using an amorphous semiconductor, and may be formed using a polycrystalline semiconductor or a microcrystalline semiconductor (semi-amorphous semiconductor: SAS).", "In addition, the mobility of holes generated by the photoelectric effect is lower than the mobility of electrons.", "Therefore, a PIN photodiode has better characteristics when a surface on the p-type semiconductor film side is used as a light-receiving plane.", "Here, an example in which light received by the photodiode 602 from a surface of the substrate 601, over which the pin photodiode is formed, is converted into electric signals is described.", "Light from the semiconductor film having a conductivity type opposite to that of the semiconductor film on the light-receiving plane is disturbance light; therefore, the electrode is preferably formed using a light-blocking conductive film.", "Note that the n-type semiconductor film side may alternatively be a light-receiving plane.", "The insulating film 632, the planarization film 633, and the planarization film 634 can be formed using an insulating material by a sputtering method, a plasma CVD method, spin coating, dipping, spray coating, a droplet discharge method (such as an inkjet method), screen printing, offset printing, or the like depending on the material.", "For the planarization films 633 and 634, for example, an organic insulating material having heat resistance, such as polyimide, acrylic resin, a benzocyclobutene-based resin, polyamide, or epoxy resin, can be used.", "Other than such organic insulating materials, it is possible to use a single layer or stacked layers of a low-dielectric constant material (a low-k material), a siloxane-based resin, phosphosilicate glass (PSG), borophosphosilicate glass (BPSG), or the like.", "With detection of light that enters the photodiode 602, data on an object to be detected can be read.", "Note that a light source such as a backlight can be used at the time of reading information on an object.", "The structure, method, and the like described in this embodiment can be used in combination with structures, methods, and the like described in other embodiments and examples, as appropriate.", "Embodiment 8 A semiconductor device disclosed in this specification can be applied to a variety of electronic devices (including game machines).", "Examples of electronic devices include a television set (also referred to as a television or a television receiver), a monitor of a computer or the like, cameras such as a digital camera and a digital video camera, a digital photo frame, a mobile phone, a portable game machine, a portable information terminal, an audio reproducing device, a game machine (e.g., a pachinko machine or a slot machine), a game console, and the like.", "Specific examples of these electronic devices are illustrated in FIGS.", "13A to 13C.", "FIG.", "13A illustrates a table 9000 having a display portion.", "In the table 9000, a display portion 9003 is incorporated in a housing 9001 and an image can be displayed on the display portion 9003.Note that the housing 9001 is supported by four leg portions 9002.Further, a power cord 9005 for supplying power is provided for the housing 9001.The semiconductor device described in any of the above embodiments can be used for the display portion 9003, so that the electronic device can have high reliability.", "The display portion 9003 has a touch-input function.", "When a user touches displayed buttons 9004 which are displayed on the display portion 9003 of the table 9000 with his/her finger or the like, the user can carry out operation of the screen and input of information.", "Further, when the table may be made to communicate with home appliances or control the home appliances, the table 9000 may function as a control device which controls the home appliances by operation on the screen.", "For example, with use of the semiconductor device having an image sensor described in Embodiment 7, the display portion 9003 can function as a touch panel.", "Further, the screen of the display portion 9003 can be placed perpendicular to a floor with a hinge provided for the housing 9001; thus, the table 9000 can also be used as a television device.", "When a television device having a large screen is set in a small room, an open space is reduced; however, when a display portion is incorporated in a table, a space in the room can be efficiently used.", "FIG.", "13B illustrates a television set 9100.In the television set 9100, a display portion 9103 is incorporated in a housing 9101 and an image can be displayed on the display portion 9103.Note that the housing 9101 is supported by a stand 9105 here.", "The television set 9100 can be operated with an operation switch of the housing 9101 or a separate remote controller 9110.Channels and volume can be controlled with an operation key 9109 of the remote controller 9110 so that an image displayed on the display portion 9103 can be controlled.", "Furthermore, the remote controller 9110 may be provided with a display portion 9107 for displaying data output from the remote controller 9110.The television set 9100 illustrated in FIG.", "13B is provided with a receiver, a modem, and the like.", "With the use of the receiver, the television set 9100 can receive general TV broadcasts.", "Moreover, when the television set 9100 is connected to a communication network with or without wires via the modem, one-way (from a sender to a receiver) or two-way (between a sender and a receiver or between receivers) information communication can be performed.", "The semiconductor device described in any of the above embodiments can be used in the display portions 9103 and 9107, so that the television set and the remote controller can have high reliability.", "FIG.", "13C illustrates a computer, which includes a main body 9201, a housing 9202, a display portion 9203, a keyboard 9204, an external connection port 9205, a pointing device 9206, and the like.", "The semiconductor device described in any of the above embodiments can be used for the display portion 9203, so that the computer can have high reliability.", "FIGS.", "14A and 14B illustrate a tablet terminal that can be folded.", "In FIG.", "14A, the tablet terminal is opened, and includes a housing 9630, a display portion 9631a, a display portion 9631b, a display-mode switching button 9034, a power button 9035, a power-saving-mode switching button 9036, a clip 9033, and an operation button 9038.The semiconductor device described in any of the above embodiments can be used for the display portion 9631a and the display portion 9631b, so that the tablet terminal can have high reliability.", "Part of the display portion 9631a can be a touch panel region 9632a, and data can be input by touching operation keys 9638 that are displayed.", "Although a structure in which a half region in the display portion 9631a has only a display function and the other half region also has a touch panel function is shown as an example, the display portion 9631a is not limited to the structure.", "However, the structure of the display portion 9631a is not limited to this, and all the area of the display portion 9631a may have a touch panel function.", "For example, all the area of the display portion 9631a can display keyboard buttons and serve as a touch panel while the display portion 9631b can be used as a display screen.", "In the display portion 9631b, as in the display portion 9631a, part of the display portion 9631b can be a touch panel region 9632b.", "When a finger, a stylus, or the like touches the place where a button 9639 for switching to keyboard display is displayed in the touch panel, keyboard buttons can be displayed on the display portion 9631b.", "Touch input can be performed concurrently on the touch panel regions 9632a and 9632b.", "The display-mode switching button 9034 allows switching between a landscape mode and a portrait mode, color display and black-and-white display, and the like.", "With the power-saving-mode switching button 9036 for switching to power-saving mode, the luminance of display can be optimized in accordance with the amount of external light at the time when the tablet is in use, which is detected with an optical sensor incorporated in the tablet.", "The tablet terminal may include another detection device such as a sensor for detecting orientation (e.g., a gyroscope or an acceleration sensor) in addition to the optical sensor.", "Although the display portion 9631a and the display portion 9631b have the same display area in FIG.", "14A, one embodiment of the present invention is not limited to this example.", "The display portion 9631a and the display portion 9631b may have different areas or different display quality.", "For example, one of them may be a display panel that can display higher-definition images than the other.", "FIG.", "14B illustrates the tablet terminal folded, which includes the housing 9630, a solar battery 9633, and a charge and discharge control circuit 9634.Note that FIG.", "14B shows an example in which the charge and discharge control circuit 9634 includes a battery 9635 and a DCDC converter 9636.Since the tablet terminal can be folded in two, the housing 9630 can be closed when the tablet terminal is not in use.", "Thus, the display portions 9631a and 9631b can be protected, thereby providing a tablet terminal with high endurance and high reliability for long-term use.", "The tablet terminal illustrated in FIGS.", "14A and 14B can also have a function of displaying various kinds of data (e.g., a still image, a moving image, and a text image), a function of displaying a calendar, a date, the time, or the like on the display portion, a touch-input function of operating or editing data displayed on the display portion by touch input, a function of controlling processing by various kinds of software (programs), and the like.", "The solar battery 9633, which is attached on the surface of the tablet terminal, supplies electric power to a touch panel, a display portion, an image signal processor, and the like.", "Note that the solar battery 9633 can be provided on one or two surfaces of the housing 9630, so that the battery 9635 can be charged efficiently.", "When a lithium ion battery is used as the battery 9635, there is an advantage of downsizing or the like.", "The structure and operation of the charge and discharge control circuit 9634 illustrated in FIG.", "14B are described with reference to a block diagram of FIG.", "14C.", "The solar battery 9633, the battery 9635, the DCDC converter 9636, a converter 9637, switches SW1 to SW3, and the display portion 9631 are illustrated in FIG.", "14C, and the battery 9635, the DCDC converter 9636, the converter 9637, and the switches SW1 to SW3 correspond to the charge and discharge control circuit 9634 illustrated in FIG.", "14B.", "First, an example of operation in the case where power is generated by the solar battery 9633 using external light is described.", "The voltage of power generated by the solar battery 9633 is raised or lowered by the DCDC converter 9636 so that a voltage for charging the battery 9635 is obtained.", "When the display portion 9631 is operated with the power from the solar battery 9633, the switch SW1 is turned on and the voltage of the power is raised or lowered by the converter 9637 to a voltage needed for operating the display portion 9631.In addition, when display on the display portion 9631 is not performed, the switch SW1 is turned off and a switch SW2 is turned on so that charge of the battery 9635 may be performed.", "Here, the solar battery 9633 is shown as an example of a power generation means; however, there is no particular limitation on a way of charging the battery 9635, and the battery 9635 may be charged with another power generation means such as a piezoelectric element or a thermoelectric conversion element (Peltier element).", "For example, the battery 9635 may be charged with a non-contact power transmission module which is capable of charging by transmitting and receiving power by wireless (without contact), or another charging means may be used in combination.", "The structure, method, and the like described in this embodiment can be used in combination with structures, methods, and the like described in other embodiments, as appropriate.", "Example 1 In this example, results of evaluating a nitride insulating film which can be used for the transistor of one embodiment of the present invention are described.", "In detail, results of evaluating the number of hydrogen molecules, ammonia molecules, and water molecules which are released by heating are described.", "First, a method for forming the evaluated samples is described.", "The formed samples each have a structure 1 or a structure 2.A silicon nitride film 993 was formed over a silicon wafer 991 by a plasma CVD method using formation conditions which can be used for the nitride insulating film 25 described in Embodiment 1 (see FIG.", "1B), so that the sample having the structure 1 was formed (see FIG.", "15A).", "The silicon nitride film 993 was formed using three conditions which are a condition 1, a condition 2, and a condition 3.The sample formed using the condition 1 is referred to as a sample A1.The sample formed using the condition 2 is referred to as a sample A2.The sample formed using condition 3 is referred to as a sample A3.The samples A1 to A3 each have the silicon nitride film 993 with a thickness of 50 nm.", "The condition 1 was as follows: the temperature of the silicon wafer 991 was 220° C.; the source gas was silane, nitrogen, and ammonia with a flow rate of 50 sccm, 5000 sccm, and 100 sccm, respectively; the pressure of the treatment chamber was 200 Pa; and the high-frequency power supplied to parallel plate electrodes was 27.12 MHz and 1000 W (the power density was 1.6×10−1 W/cm2).", "The flow ratio of nitrogen to ammonia was 50.The condition 2 was the same as the condition 1 except that the high-frequency power supplied to parallel plate electrodes was 150 W (the power density was 2.5×10−2 W/cm2).", "The condition 3 was as follows: the temperature of the silicon wafer 991 was 220° C.; the source gas was silane, nitrogen, and ammonia with a flow rate of 30 sccm, 1500 sccm, and 1500 sccm, respectively; the pressure of the treatment chamber was 200 Pa; and the high-frequency power supplied to parallel plate electrodes was 27.12 MHz and 150 W (the power density was 2.5×10−2 W/cm2).", "The flow ratio of nitrogen to ammonia was 1.TDS analyses were performed on the samples A1 to A3.In each of the samples, the silicon wafer 991 was heated at 65° C. or higher and 610° C. or lower.", "The peaks of the curves shown in the results obtained from TDS appear due to release of atoms or molecules contained in the analyzed samples (in this example, the samples A1 to A3) to the outside.", "The total number of the atoms or molecules released to the outside corresponds to the integral value of the peak.", "Thus, with the degree of the peak intensity, the number of the atoms or molecules contained in the silicon nitride film can be evaluated.", "FIGS.", "16A to 16C and FIGS.", "17A and 17B show the results of the TDS analyses on the samples A1 to A3.FIG.", "16A is a graph of the amount of a released gas which has a M/z of 2, typically hydrogen molecules, against the substrate temperature.", "FIG.", "16B is a graph of the amount of a released gas which has a M/z of 18, typically water molecules, against the substrate temperature.", "FIG.", "16C is a graph of an amount of released hydrogen molecules calculated from an integral value of a peak of a curve in FIG.", "16A.", "FIG.", "17A is a graph of the amount of a released gas which has a M/z of 17, typically ammonia molecules, against the substrate temperature.", "FIG.", "17B is a graph of an amount of released ammonia molecules calculated from an integral value of a peak of a curve in FIG.", "17A.", "In these TDS analyses, the lower limit of detection of hydrogen molecules was 1×1021 molecules/cm3, and, the lower limit of detection of ammonia molecules was 2×1020 molecules/cm3.As shown in FIG.", "16A, the TDS intensity of hydrogen molecules of the sample A2 is higher than that of the sample A1 and that of the sample A3.As shown in FIG.", "16C, the amount of released hydrogen molecules of the sample A2 against the substrate temperature is approximately five times that of the sample A1 and the sample A3.As shown in FIG.", "16B, in the samples A1 to A3, a peak indicating the release of water molecules is seen when the temperature of each substrate was in the range from higher than or equal to 100° C. to lower than or equal to 200° C. Note that only in the sample A3, a sharp peak was detected in the range.", "In contrast, as shown in FIG.", "17A, the TDS intensity of ammonia molecules of the sample A3 is higher than that of the sample A1 and the sample A2.As shown in FIG.", "17B, the amount of released ammonia molecules of the sample A3 against the substrate temperature is at least approximately greater than or equal to 16 times that of the sample A1 and the sample A2.The amount of released ammonia molecules of the sample A2 is less than or equal to the lower limit of detection.", "Next, the structure 2 which was employed to some of the formed samples is described.", "A silicon oxynitride film 995 was formed over the silicon wafer 991 by a plasma CVD method using formation conditions which can be used for the insulating film 24b described in Embodiment 4 (see FIG.", "6B), and the silicon nitride film 993 was formed over the silicon oxynitride film 995 in a manner similar to the structure 1, so that the sample having the structure 2 was formed (see FIG.", "15B).", "In each of the samples having the structure 2, in order to evaluate an effect of suppressing movement of water in the silicon nitride film 993, the silicon oxynitride film 995 is a silicon oxynitride film whose oxygen content is in excess of that in the stoichiometric composition.", "FIGS.", "19A and 19B show the results of TDS analyses on samples in each of which only the silicon oxynitride film 995 having a thickness of 400 nm was formed over a silicon wafer.", "In each of the samples, the silicon wafer 991 was heated at 70° C. or higher and 570° C. or lower.", "FIG.", "19A is a graph of the amount of a released gas which has a M/z of 32, typically oxygen molecules, against the substrate temperature.", "FIG.", "19B is a graph of the amount of a released gas which has a M/z of 18, typically water molecules, against the substrate temperature.", "The silicon oxynitride film whose oxygen content is in excess of that in the stoichiometric composition contains not only oxygen (see FIG.", "19A) but also water (see FIG.", "19B); thus, by evaluating an amount of released water molecules against the substrate temperature of the samples A4 to A6 having the structure 2, whether or not the silicon nitride film 993 has an effect of suppressing movement of water can be evaluated.", "The formation conditions of the silicon oxynitride film 995 was as follows: the temperature of the silicon wafer 991 was 220° C.; the source gas was silane and nitrogen monoxide with a flow rate of 160 sccm and 4000 sccm, respectively; the pressure of the treatment chamber was 200 Pa; and the high-frequency power supplied to parallel plate electrodes was 27.12 MHz and 1500 W (the power density was 2.5×10−1 W/cm2).", "The thickness of the silicon oxynitride film 995 was 400 nm.", "In the samples having the structure 2, the silicon nitride film 993 was formed using the three conditions, which are the condition 1, the condition 2, and the condition 3.The sample which has the structure 2 and is formed using the condition 1 is referred to as a sample A4.The sample which has the structure 2 and is formed using the condition 2 is referred to as a sample A5.The sample which has the structure 2 and is formed using the condition 3 is referred to as a sample A6.The samples A4 to A6 each have the silicon nitride film 993 with a thickness of 50 nm.", "The details of the conditions 1 to 3 are the same as those of the structure 1.TDS analyses were performed on the samples A4 to A6 in order to evaluate an effect of suppressing movement of water.", "In each of the samples, the silicon wafer 991 was heated at 70° C. or higher and 580° C. or lower.", "FIGS.", "18A and 18B show the results of the TDS analyses on the samples A4 to A6 having the structure 2.FIG.", "18A is a graph of an amount of released hydrogen molecules against the substrate temperature.", "FIG.", "18B is a graph of an amount of released water molecules against the substrate temperature.", "As shown in FIG.", "18A, the TDS intensity of hydrogen molecules of the sample A5 is higher than that of the sample A4 and that of the sample A6.As shown in FIG.", "18B, a minor peak is seen in the TDS intensity of water molecules; however, large difference is not seen among the samples A4 to A6.The samples A4 to A6 having the structure 2 each have a very low intensity of a peak indicating the release of water molecules despite the presence of the silicon oxynitride film 995 containing water.", "Thus, with the formation conditions of the samples A4 to A6, an insulating film which can suppress movement of water.", "However, the sample A2 including a silicon nitride film using a condition similar to that of the sample A5 has a large number of released hydrogen molecules, and the sample A3 has a large number of released ammonia molecules.", "In a transistor including an oxide semiconductor, when hydrogen and nitrogen are contained in an oxide semiconductor film, electrons serving as carriers are generated in the oxide semiconductor film and the transistor becomes normally on.", "Thus, hydrogen molecules and ammonia molecules which are sources for supplying nitrogen are both impurities which change electrical characteristics of a transistor.", "For example, in the sample A3, the amount of released ammonia molecules is large, which means that there are many nitrogen sources, and by forming such an insulating film over a transistor or in a gate insulating film of a transistor, the transistor becomes normally on.", "Thus, the nitride insulating film which releases a small number of hydrogen molecules and ammonia molecules, such as the silicon nitride film formed under the condition 1 used in the sample A1 and the sample A4 is provided over a transistor including an oxide semiconductor film.", "As a result, a transistor in which a change in electrical characteristics is suppressed or a transistor whose reliability is improved can be manufactured.", "Further, as a gate insulating film of the transistor including the oxide semiconductor film, a nitride insulating film which releases a small number of released hydrogen molecules and released ammonia molecules, such as a silicon nitride film formed under the condition 1 using in the samples A1 and A4, is provided, whereby a transistor in which variation in electrical characteristics is suppressed or a transistor with improved reliability can be manufactured.", "Next, transistors including silicon nitride films formed under the conditions 1 to 3 were manufactured and the Vg-Id characteristics were measured.", "A manufacturing process of a transistor included in each of a sample B1, a sample B2, and a sample B3 is described.", "In this example, the process is described with reference to FIGS.", "2A to 2D.", "First, as illustrated in FIG.", "2A, a glass substrate was used as the substrate 11, and the gate electrode 15 was formed over the substrate 11.A 100 nm-thick tungsten film was formed by a sputtering method, a mask was formed over the tungsten film by a photolithography process, and part of the tungsten film was etched with the use of the mask, so that the gate electrode 15 was formed.", "Next, the gate insulating film 18 was formed over the gate electrode 15.As the gate insulating film 18, a stacked layer including a 50-nm-thick silicon nitride film and a 200-nm-thick silicon oxynitride film were stacked.", "The silicon nitride film was formed in the following conditions: silane and nitrogen were supplied at 50 sccm and 5000 sccm, respectively, into a treatment chamber of a plasma CVD apparatus; the pressure of the treatment chamber was adjusted to 60 Pa; and power of 150 W was supplied with the use of a 27.12 MHz high-frequency power source.", "The silicon oxynitride film was formed in the following conditions: silane and dinitrogen monoxide were supplied at 20 sccm and 3000 sccm, respectively, into the treatment chamber of the plasma CVD apparatus; the pressure of the treatment chamber was adjusted to 40 Pa; and power of 100 W was supplied with the use of a 27.12 MHz high-frequency power source.", "Note that each of the silicon nitride film and the silicon oxynitride film was formed at a substrate temperature of 350° C. Next, the oxide semiconductor film 19 overlapping with the gate electrode 15 with the gate insulating film 18 provided therebetween was formed.", "Here, an IGZO film which was a CAAC-OS film was formed over the gate insulating film 18 by a sputtering method, a mask is formed over the IGZO film by a photolithography process, and the IGZO film was partly etched using the mask.", "Then, the etched IGZO film was subjected to heat treatment, so that the oxide semiconductor film 19 was formed.", "Note that the IGZO film formed in this example has a thickness of 35 nm.", "The IGZO film was formed in such a manner that a sputtering target where In:Ga:Zn=1:1:1 (atomic ratio) was used, argon and oxygen were supplied as a sputtering gas into a treatment chamber of a sputtering apparatus at a flow rate of 50 sccm for each, the pressure in the treatment chamber was controlled to be 0.6 Pa, and direct-current power of 5 kW was supplied.", "Note that the IGZO film was formed at a substrate temperature of 170° C. Next, water, hydrogen, and the like contained in the oxide semiconductor film were released by heat treatment.", "Here, heat treatment at 450° C. for one hour in a nitrogen atmosphere was performed, and then heat treatment at 450° C. for one hour in an atmosphere of nitrogen and oxygen was performed.", "For the structure obtained through the steps up to here, FIG.", "2B can be referred to.", "Next, after the gate electrode was exposed by etching a part of the gate insulating film 18 (not illustrated), the pair of electrodes 21 in contact with the oxide semiconductor film 19 was formed as illustrated in FIG.", "2C.", "A conductive film was formed over the gate insulating film 18 and the oxide semiconductor film 19, a mask was formed over the conductive film by a photolithography process, and the conductive film was partly etched using the mask, so that the pair of electrodes 21 was formed.", "Note that as the conductive film, a 400-nm-thick aluminum film was formed over a 50-nm-thick tungsten film, and a 100-nm-thick titanium film was formed over the aluminum film.", "Next, after the substrate was moved to a treatment chamber under reduced pressure and heated at 220° C., the substrate was moved to a treatment chamber filled with dinitrogen monoxide.", "Then, the oxide semiconductor film 19 was exposed to oxygen plasma which was generated in such a manner that an upper electrode provided in the treatment chamber was supplied with high-frequency power of 150 W with the use of a 27.12 MHz high-frequency power source.", "Next, the insulating film 23 was formed in succession over the oxide semiconductor film 19 and the pair of electrodes 21 without exposure to the atmosphere after the above plasma treatment.", "A 50-nm-thick first silicon oxynitride film and a 400-nm-thick second silicon oxynitride film were stacked.", "The first silicon oxynitride film was formed by a plasma CVD method under the following conditions: silane with a flow rate of 30 sccm and dinitrogen monoxide with a flow rate of 4000 sccm were used as a source gas, the pressure in a treatment chamber was 40 Pa, the substrate temperature was 220° C., and high-frequency power of 150 W was supplied to parallel-plate electrodes.", "The second silicon oxynitride film was formed by a plasma CVD method under the following conditions: silane with a flow rate of 160 sccm and dinitrogen monoxide with a flow rate of 4000 sccm were used as a source gas, the pressure in the treatment chamber was 200 Pa, the substrate temperature was 220° C., and high-frequency power of 1500 W was supplied to the parallel-plate electrodes.", "Under the above conditions, it is possible to form a silicon oxynitride film whose oxygen content is in excess of that in the stoichiometric composition and from which part of oxygen is released by heating.", "Next, water, hydrogen, and the like were released from the insulating film 23 by heat treatment.", "Here, the heat treatment was performed in an atmosphere of nitrogen and oxygen at 350° C. for one hour.", "Next, as illustrated in FIG.", "2D, the nitride insulating film 25 was formed over the insulating film 23.In the sample B1, as the nitride insulating film 25, the silicon nitride film was formed under the condition 1 of the sample A1.In the sample B2, as the nitride insulating film 25, the silicon nitride film was formed under the condition 2 of the sample A2.In the sample B3, as the nitride insulating film 25, the silicon nitride film was formed under the condition 3 of the sample A3.Next, although not illustrated, parts of the insulating film 23 and the nitride insulating film 25 were etched, and openings which expose part of the pair of electrodes were formed.", "Next, a planarization film (not illustrated) was formed over the nitride insulating film 25.Here, the nitride insulating film 25 was coated with a composition, and exposure and development were performed, so that a planarization film having an opening through which the pair of electrodes is partly exposed was formed.", "Note that as the planarization film, a 1.5-μm-thick acrylic resin was formed.", "Then, heat treatment was performed.", "The heat treatment was performed at a temperature of 250° C. in a nitrogen atmosphere for one hour.", "Next, a conductive film connected to part of the pair of electrodes is formed (not illustrated).", "Here, a 100-nm-thick ITO film containing silicon oxide was formed by a sputtering method.", "Through these steps, transistors in the samples B1 to B3 were manufactured.", "Next, Vg-Id characteristics of the transistors in the samples B1 to B3 were measured.", "Next, a pressure cooker test (PCT) was performed as the accelerated life test to evaluate moisture resistance.", "In the PCT in this example, the samples B1 to B3 were held for 15 hours under the following conditions: the temperature was 130° C., the humidity was 85%, and the pressure was 0.23 MPa.", "FIGS.", "20A to 20C, FIGS.", "21A to 21C, and FIGS.", "22A to 22C show Vg-Id initial characteristics of the transistors included in the samples B1 to B3 and Vg-Id characteristics of the transistors included in the samples B1 to B3 after the pressure cooker test.", "Note that in each of the samples, Vg-Id characteristics of a transistor 1 whose channel length (L) is 2 μm and channel width (W) is 50 μm and a transistor 2 whose channel length (L) is 6 μm and channel width (W) is 50 μm were measured.", "The initial characteristics of the transistors 1 in the samples B1 to B3 are shown in FIG.", "20A, FIG.", "21A, and FIG.", "22A, the initial characteristics of the transistors 2 in the samples B1 to B3 are shown in FIG.", "20B, FIG.", "21B, and FIG.", "22B, and the Vg-Id characteristics of the transistors 2 in the samples B1 to B3 after the pressure cooker test are shown in FIG.", "20C, FIG.", "21C, and FIG.", "22C.", "Further, in each of the samples, 24 transistors having the same structure were manufactured on the substrate.", "According to the Vg-Id characteristics shown in FIG.", "21A, the transistors do not have switching characteristics.", "Further, according to the Vg-Id characteristics shown in FIG.", "22A, variation in threshold voltage of the transistors is large.", "However, according to the Vg-Id characteristics shown in FIG.", "20A, it is found that the transistors has favorable switching characteristics and variation in threshold voltage of the transistors is small.", "It is found that variation in threshold voltage of the transistor in the initial characteristics of the Vg-Id characteristics shown in FIG.", "20B and FIG.", "22B is smaller than that in the initial characteristics of the Vg-Id characteristics shown in FIG.", "21B.", "The Vg-Id characteristics shown in FIG.", "20C have more favorable switching characteristics than the Vg-Id characteristics after the pressure cooker test shown in FIG.", "21C and FIG.", "22C.", "For the above reasons, a nitride insulating film which releases a small number of hydrogen molecules and ammonia molecules is formed over a transistor, whereby a shift of threshold voltage in the negative direction can be reduced and the reliability of the transistor can be improved.", "Next, a plurality of samples was manufactured by forming the nitride insulating film 25 through the same process as the samples B1 to B3 in this example and under a condition other than the conditions 1 to 3.In each of the samples, 24 transistors having the same structure were formed on the substrate, and the Vg-Id initial characteristics of the transistors were compared to one another.", "Note that in each of the transistors, the channel length (L) is 2 μm and the channel width (W) is 50 μm.", "FIG.", "23 shows a relation between an amount of released hydrogen molecules and an amount of released ammonia molecules from the nitride insulating film 25 and the Vg-Id initial characteristics of the transistors in the plurality of samples in which the nitride insulating film 25 is formed under a condition of the samples B1 to B3 or a condition other than the conditions 1 to 3.In FIG.", "23, the horizontal axis indicates the amount of hydrogen molecules released from the nitride insulating film 25 and the vertical axis indicates the amount of ammonia molecules released from the nitride insulating film 25.Further, in FIG.", "23, circles indicate that the difference between the maximum threshold voltage and the minimum threshold voltage (Vth_max−Vth_min) in the 24 transistors on the substrate is less than or equal to 1 V. Further, triangles indicate that Vth_max−Vth_min is greater than 1 V and less than or equal to 3 V. Further, crosses indicate that Vth_max−Vth_min is greater than 3 V. In FIG.", "23, crosses are not plotted in the region where the amount of released hydrogen molecules from the nitride insulating film 25 is smaller than 5×1021 molecules/cm3 and the amount of released ammonia molecules from the nitride insulating film 25 is smaller than 1×1022 molecules/cm3.Accordingly, it is found that a nitride insulating film which releases hydrogen molecules less than 5×1021 molecules/cm3 and ammonia molecules less than 1×1022 molecules/cm3 is provided over a transistor, whereby variation in threshold voltage of the transistor can be reduced.", "Moreover, a shift of the threshold voltage in the negative direction can be suppressed.", "REFERENCE NUMERALS 1: transistor, 3: transistor, 5: transistor, 7: transistor, 9: transistor, 11: substrate, 15: gate electrode, 18: gate insulating film, 19: oxide semiconductor film, 21: electrode, 23: insulating film, 24a: insulating film, 24b: insulating film, 25: nitride insulating film, 26: protective film, 27: planarization film, 28: protective film, 29: conductive film, 30: opening, 31: substrate, 33: base insulating film, 34: oxide semiconductor film, 35: electrode, 37: insulating film, 38a: insulating film, 38b: insulating film, 39: nitride insulating film, 40: gate insulating film, 41: gate electrode, 42: gate insulating film, 43: planarization film, 45: conductive film, 47: opening, 61: gate electrode, 601: substrate, 602: photodiode, 606a: semiconductor film, 606b: semiconductor film, 606c: semiconductor film, 608: adhesive layer, 613: substrate, 632: insulating film, 633: planarization film, 634: planarization film, 640: transistor, 641a: electrode, 641b: electrode, 642: electrode, 643: conductive film, 645: conductive film, 656: transistor, 658: photodiode reset signal line, 659: gate signal line, 671: photo sensor output signal line, 672: photo sensor reference signal line, 901: substrate, 902: pixel portion, 903: signal line driver circuit, 904: scan line driver circuit, 905: sealant, 906: substrate, 908: liquid crystal layer, 910: transistor, 911: transistor, 913: liquid crystal element, 915: connection terminal electrode, 915a: connection terminal electrode, 915b: connection terminal electrode, 916: terminal electrode, 917: conductive film, 918: FPC, 918b: FPC, 919: anisotropic conductive agent, 921: planarization film, 922: gate insulating film, 923: insulating film, 924: insulating film, 925: sealant, 930: electrode, 931: electrode, 932: insulating film, 933: insulating film, 935: spacer, 936: sealant, 941: electrode, 943: liquid crystal element, 944: insulating film, 950: silicon nitride film, 951: electrode, 955: connection terminal electrode, 960: partition wall, 961: light-emitting layer, 963: light-emitting element, 964: filler, 971: source electrode, 973: drain electrode, 975: common potential line, 977: common electrode, 985: common potential line, 987: common electrode, 991: silicon wafer, 993: silicon nitride film, 995: silicon oxynitride film, 9000: table, 9001: housing, 9002: leg portion, 9003: display portion, 9004: displayed button, 9005: power cord, 9033: clip, 9034: switching button, 9035: power button, 9036: switching button, 9038: operation button, 9100: television set, 9101: housing, 9103: display portion, 9105: stand, 9107: display portion, 9109: operation key, 9110: remote controller, 9201: main body, 9202: housing, 9203: display portion, 9204: keyboard, 9205: external connection port, 9206: pointing device, 9630: housing, 9631: display portion, 9631a: display portion, 9631b: display portion, 9632a: region, 9632b: region, 9633: solar battery, 9634: charge and discharge control circuit, 9635: battery, 9636: DCDC converter, 9637: converter, 9638: operation key, 9639: button.", "This application is based on Japanese Patent Application serial no.", "2012-147703 filed with Japan Patent Office on Jun.", "29, 2012, the entire contents of which are hereby incorporated by reference." ] ]
Patent_15874227
[ [ "PRIORITY-BASED ENERGY MANAGEMENT", "A system for controlling operation of a plurality of appliances includes first and second appliances.", "The first appliance is configured to report a power consumption via a network.", "A second appliance is configured to operate dependent on the power consumption reported by the first appliance." ], [ "1.A system for controlling operation of a plurality of appliances, comprising: a first appliance configured to report a power consumption; a second appliance configured to operate based on the power consumption reported by the first appliance; and a load controller configured to: determine for the first and second appliances, respective first and second operating priorities; utilize a cost function to determine cost of power received during different time periods and lower the operating priorities during peak pricing periods to reduce cost of operating the system; and control the operation of the first and second appliances based on the operating priorities.", "2.The system of claim 1, wherein the determining is being based on an integral of historical or future priority functions associated with each of the first and second appliances and allows the load controller to estimate future operating priorities for the first and second appliances.", "3.The system of claim 1, wherein at least one of the first and second appliances is a heating, ventilating and air conditioning system component.", "4.The system of claim 1, wherein at least one of the first and second appliances is a resistive load.", "5.The system of claim 1, wherein the load controller determines the first or second priority based on a predicted outside air temperature.", "6.The system of claim 1, wherein the load controller is further configured to: determine an efficiency map that characterizes a total power consumption of the first and second appliances; and control the operation of the first and second appliances based on the efficiency map.", "7.The system of claim 1, wherein the load controller is further configured to communicate with the first and second appliances, the communication allowing dynamic optimization of interrelated operation of the first and second appliances for greater efficiency.", "8.The system of claim 1, wherein the first or second operating priority determined to prevent the first and second appliances from exceeding a maximum aggregate power consumption.", "9.A method of manufacturing a network of appliances, comprising: configuring a first appliance to report a power consumption; configuring a second appliance to operate dependent on the power consumption reported by the first appliance; and configuring a load controller to: determine for the first and second appliances, respective first and second operating priorities; utilize a cost function to determine cost of power received during different time periods and lowering the operating priorities during peak pricing periods to reduce cost of operation; and control the operation of the first and second appliances based on the operating priorities.", "10.The method of claim 9, wherein the determining is based on an integral of historical or future priority functions associated with each of the first and second appliances and allows the load controller to estimate future operating priorities for the first and second appliances.", "11.The method of claim 9, wherein at least one of the first and second appliances is a heating, ventilating and air conditioning system component.", "12.The method of claim 9, wherein at least one of the first and second appliances is a resistive load.", "13.The method of claim 9, wherein the first or second operating priority is determined to prevent the first and second appliances from exceeding a maximum aggregate power consumption.", "14.A load controller for controlling a networked plurality of appliances, comprising: a processor configured to execute program instructions stored by a program memory; a priority calculation module defined by the program instructions that is configured to: calculate operating priorities of first and second networked appliances; utilize a cost function to determine cost of power received during different time periods and lower the operating priorities during peak pricing periods to reduce cost of operation; and the processor being further configured to control the operation of the first and second networked appliances based on the operating priorities.", "15.The load controller of claim 14, wherein the calculation of operating priorities is based on an integral of historical or future priority functions, wherein the priority functions are associated with each of the first and second appliances, wherein the calculation allows the load controller to estimate future operating priorities for the first and second appliances.", "16.The load controller of claim 14, wherein at least one of the first and second appliances is a heating, ventilating and air conditioning system component.", "17.The load controller of claim 14, wherein at least one of the first and second appliances is a resistive load.", "18.The load controller of claim 14, wherein the priority calculation module determines the first or second operating priority based on a predicted outside air temperature.", "19.The load controller of claim 17, wherein the operating priorities are determined to prevent the first and second appliances from exceeding a maximum aggregate power consumption.", "20.The load controller of claim 17, wherein the load controller is configured to limit an operating power of a variable speed motor to a nonzero power that is less than a maximum operating power." ], [ "<SOH> BACKGROUND <EOH>Power generation and distribution infrastructure are finite resources.", "Often, sufficient power generating capacity is made available to a power distribution grid to meet peak power demand requirements within the grid.", "When the power demand is less than the peak demand, some of the excess power generating capacity may be idled.", "In some cases, such as when power generation capacity is needed to meet a peak seasonal load, such excess capacity may be idled for several months of the year.", "The capital cost associated with the idled excess capacity is spread among the power consumers on the grid throughout the year, increasing the overall cost of power delivery.", "New methods and systems are needed to reduce the peak power demands on a power grid, and to otherwise reduce variation e.g.", "seasonal variation, of power demand to reduce the cost of providing excess capacity to meet peak demand requirements." ], [ "<SOH> SUMMARY <EOH>One embodiment provides a system for controlling operation of a plurality of networked appliances.", "The system includes first and second appliances.", "The first appliance is configured to report a power consumption via a network.", "A second appliance is configured to operate dependent on the power consumption reported by the first appliance.", "Another embodiment provides a method of manufacturing a network of appliances.", "The method includes configuring a first appliance report a power consumption via a communication path.", "The method further includes configuring a second appliance to operate dependent on the power consumption reported by the first appliance.", "Yet another embodiment provides a load controller for controlling a networked plurality of appliances.", "The load controller includes a processor configured to execute program instructions stored by a program memory.", "The memory includes instructions for executing a priority calculation module.", "The priority calculation module operates to calculate operating priorities of first and second networked appliances.", "The processor is further configured to control operation of the first and second networked appliances based on the operating priorities." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application claims the benefit of U.S.", "Provisional Application Ser.", "No.", "61/423,754, filed by Wojciech Grohman on Dec. 16, 2010, entitled “Priority-Based Energy Management,” commonly assigned with this application and incorporated herein by reference.", "TECHNICAL FIELD This application is directed, in general, to systems and methods for managing power-consuming devices connected to an electric utility grid.", "BACKGROUND Power generation and distribution infrastructure are finite resources.", "Often, sufficient power generating capacity is made available to a power distribution grid to meet peak power demand requirements within the grid.", "When the power demand is less than the peak demand, some of the excess power generating capacity may be idled.", "In some cases, such as when power generation capacity is needed to meet a peak seasonal load, such excess capacity may be idled for several months of the year.", "The capital cost associated with the idled excess capacity is spread among the power consumers on the grid throughout the year, increasing the overall cost of power delivery.", "New methods and systems are needed to reduce the peak power demands on a power grid, and to otherwise reduce variation e.g.", "seasonal variation, of power demand to reduce the cost of providing excess capacity to meet peak demand requirements.", "SUMMARY One embodiment provides a system for controlling operation of a plurality of networked appliances.", "The system includes first and second appliances.", "The first appliance is configured to report a power consumption via a network.", "A second appliance is configured to operate dependent on the power consumption reported by the first appliance.", "Another embodiment provides a method of manufacturing a network of appliances.", "The method includes configuring a first appliance report a power consumption via a communication path.", "The method further includes configuring a second appliance to operate dependent on the power consumption reported by the first appliance.", "Yet another embodiment provides a load controller for controlling a networked plurality of appliances.", "The load controller includes a processor configured to execute program instructions stored by a program memory.", "The memory includes instructions for executing a priority calculation module.", "The priority calculation module operates to calculate operating priorities of first and second networked appliances.", "The processor is further configured to control operation of the first and second networked appliances based on the operating priorities.", "BRIEF DESCRIPTION Reference is now made to the following descriptions taken in conjunction with the accompanying drawings, in which: FIG.", "1 illustrates a system An one illustrative and nonlimiting embodiment, in which various appliances, or loads, operate within a structure, wherein the operation is managed, e.g.", "according to an operating priority of each load to achieve desired aggregate power consumption characteristics within the structure; FIG.", "2 presents a functional block diagram of a controller, e.g.", "a load manager of FIG.", "1; FIGS.", "3A-3D illustrate examples of priority functions that may be used by various loads within the system of FIG.", "1; FIG.", "4 illustrates without limitation example priority functions of three appliances having different sensitivities to deviations from an operating setpoint; FIG.", "5 illustrates priority functions of several generalized including historical and estimated priorities; FIG.", "6 illustrates aspects of an embodiment in which power is allocated, e.g.", "based on a prediction of cooling load on an HVAC system; FIGS.", "7A and 6B illustrate an illustrative and nonlimiting embodiment in which a forecast of operating priority and operating power is used to allocate power among various loads, e.g.", "to reduce the peak load demand within the structure of FIG.", "1; FIG.", "8 illustrates an efficiency map of an appliance of FIG.", "1 in one nonlimiting embodiment; and FIG.", "9 presents a method of the disclosure, e.g.", "for manufacturing the system of FIG.", "1.DETAILED DESCRIPTION This disclosure benefits from the recognition by the inventor that emerging technologies that provide communication between electrical loads within a residential or commercial structure may be beneficially applied to manage the operation of the loads.", "Load management may include algorithms that by dynamically adjusting priorities can restrict the simultaneous operation of multiple loads to enforce an aggregate power budget of the loads.", "Moreover, the impact of the load operation on a grid supplying power to the loads, and the cost of operating the loads, may be reduced relative to unrestricted operation.", "Such management offers the potential to reduce the need for peak power generation capacity and to lower the maximum peak power for which a power distribution grid is designed to operate.", "FIG.", "1 illustrates an embodiment of a system 100 of the disclosure in which a load manager coordinates the operation of a number of electrical loads, generally referred to as appliances.", "Herein an appliance is a device that operates using AC power locally generated or delivered via an electric utility grid, wherein the device provides a service, such as heating or performing work.", "For example, the appliance may be a motor that drives a compressor, a fan, a blower or a pump, or may be a heat generating device such as a heating coil of a furnace, oven stove or dryer.", "The appliances draw power from a power source that supplies electrical power to a structure 105, e.g.", "a residential structure.", "In various embodiments the power source is a power grid, but the principles described herein may be applied to other sources such as a local generator, renewable power source, or other energy delivery types, such as DC voltage systems.", "As described further below, the coordination includes prioritization of operation of the appliances to meet at least one power consumption objective.", "Examples of power consumption objectives include minimizing variation of an aggregate power consumption, or load, of the system 100, reducing a peak power consumption of the aggregate of all loads within the system 100, and reducing an overall cost of operation of the appliances within the system 100.The system 100 is illustrated without limitation as being contained within a residential structure 105.1t will be immediately apparent to those skilled in the pertinent art that the principles of the disclosure may be applied to other aggregates of power loads, such as commercial buildings and manufacturing facilities.", "An outdoor HVAC unit 110 (hereinafter “outdoor unit 110”) includes a compressor motor 115a and a fan motor 115b.", "Similarly, an outdoor HVAC unit 120 (hereinafter “outdoor unit 120”) includes a compressor motor 115c and a fan motor 115d.", "One or both of the HVAC units 110, 120 may be a heat pump system.", "The outdoor unit 110 operates with an associated indoor unit 130 that includes a blower motor 115e and a heating coil or furnace 115f.", "The outdoor unit 120 operates with an associated indoor unit 140 that includes a blower motor 115g and a heating coil or furnace 115h.", "The structure 105 may also include appliances other than those providing HVAC services, exemplified by a sump pump motor 115i, an attic fan motor 115j, a refrigerator 170 including a compressor 115k, and an oven/range 175 having heating elements 115l.", "Various ones of the appliances are primarily inductive loads, e.g.", "the aforementioned motors.", "Other ones of the appliances are primarily resistive loads, e.g.", "the heating coils 115f, 115h and the heating coils 115l.", "The various motors and heating elements are referred to collectively as appliances 115.Some of the illustrated appliances are configured to provide HVAC services to first and second conditioned spaces 190 and 195.For example, the outside unit 110 and the inside unit 130 provide heating and/or cooling to the first conditioned space 190, and the outside unit 120 and the inside unit 140 provide heating and/or cooling to the second conditioned space 195.Those skilled in the pertinent art will appreciate that the illustrated configuration of the appliances 115 is illustrative and does not limit embodiments of the invention to any particular configuration.", "The structure 105 also includes a communication network, or path, 180.The communication network 180 interconnects the various appliances within the structure 105.The communication network 180 may be implemented by any conventional or novel wired or wireless communication protocol any combination of thereof.", "For the purpose of illustration without limitation, the protocol may include any revision of the following: a universal serial bus (USB), IEEE 1394 (Firewire™), Thunderbolt™, RS-232, IEEE 802.3 or the Ethernet, any of the IEEE 802.15.4-based.", "protocols, such as Zigbee, Z-wave, 802.11a/b/g/n, the suite of communication standards commonly referred to as the “internet”, wired or wireless LAN, Power Line Carrier (PLC) technology, such as in the emerging standards IEEE 1901-2010, IEEE P1901.2, IEEE P1905, or a serial bus conforming to the TIA/EIA-485 standard or the Bosch CAN (controller area network) standard.", "Without limitation, one embodiment of such a network is provided in U.S. patent application Ser.", "No.", "12/603,526 to Grohman, et al., incorporated herein by reference.", "Load managers 183, 186 operate on the communication network 180 to coordinate operation of the various appliances 115.Each of the appliances includes the capability to communicate with one or both of the load mangers 183, 186 via the communication network 180.In one aspect one or both of the load managers 183, 186 provides typical HVAC functions, such as providing a means to select a temperature setpoint of the respective conditioned spaces 190, 195.In some cases one or both load managers 183, 186 may communicate outside the structure 105, such as to report various aspects of operation within the structure 105 to an outside entity, or to receive communications that may include a power consumption objective, such as a maximum permitted aggregate power usage within the structure 105.In some embodiments the load managers 183, 186 are configured to provide similar functionality within the system, 100, and may be multiple instances of nominally identical units.", "For brevity the remaining discussion may describe certain features of one or both load managers 183, 186 by referring to only one of the units.", "In such cases, it is understood that such features may also be provided by the other of the units.", "It is understood that the number of load managers is not limited and can be substantially higher than two in any given residential, industrial or commercial location.", "It is also understood that the load managers can be physically separated from any HVAC equipment and only connected to the equipment via a communication network, such as the network 180.The load managers 183, 186 may include a processing capability, e.g.", "a memory and a processor.", "In some embodiments one or both load managers 183, 186 coordinate the operation of the several appliances in addition to those appliances providing HVAC services.", "In other embodiments one or more of the appliances includes a distributed control capability, such as by a local load manager (LLM) 151 associated with the sump pump motor 115i.", "In some embodiments each of the appliances 115 includes an instance of the LLM 151.Such local controllers may include the ability to control the operation of other appliances 115 within the system 100, but typically do not include aspects of HVAC operation such as temperature setpoint entry and display.", "Features of the load managers 183 and 186 described herein may be present in the LLM 151 unless otherwise stated.", "The load managers 183, 186 and/or 151 may include any combination of hardware, such as microcontrollers, volatile and nonvolatile memory, sensors and communications interfaces necessary to execute the predictive and control functions.", "Configuration may include software in any form stored in memory, including machine-level coding and higher level coding languages such as C, C++, C# and Java.", "Some embodiments are described by, e.g.", "U.S. patent application Ser.", "No.", "12/857,685 to Grohman (hereinafter the '685 application), incorporated herein by reference in its entirety.", "Another embodiment is described in FIG.", "2, below.", "FIG.", "2 illustrates a load manager 200 configured to provide the described control of the system 100 according to various embodiments of the disclosure.", "The load manager may describe aspects of each of the load managers 183, 186 and 151.The load manager 200 includes a processor 210, a memory 220, and a network interface 240.It may optionally also include a comfort sensor (CS) interface 230.Those skilled in the art will appreciate the division of functionality between these modules may be allocated in a different manner than described herein and remain within the scope of the invention.", "The processor 210 may be any type of electronic controller, e.g.", "a general microprocessor or microcontroller, digital signal processor (DSP), an ASIC device configured to implement controller functions, a state machine, etc.", "Similarly the memory 220 may be any type or memory, e.g.", "static random access memory (SRAM), dynamic random access memory (DRAM), programmable read-only memory (PROM), flash memory, magnetic memory, and the like.", "The optional CS interface 230 may be any configuration of electronic devices configured to communicate with a temperature sensor and/or a humidity sensor to provide feedback for HVAC temperature and humidity conditioning.", "Similarly, the network interface 240 may be any configuration of electronic devices configured to communicate with the other entities in the system 100, either by wired or wireless networking as previously described.", "The memory 220 provides program instructions 250 to the processor 210 that guide overall operation of the system 100, including various conventional functions.", "More specifically, the instructions 250 provide instructions to implement a priority calculation module 260 that operates according to various embodiments described herein below to calculate, e.g.", "operating priorities of appliances 115, power consumption metrics of the system 100 and/or an efficiency map that characterizes a total power consumption of the system 100 based on the calculated operating priorities.", "The memory 220 may also include a performance history portion 270 that stores historical performance data to support calculations of the various power consumption characteristics and the efficiency maps as described herein.", "The load managers 183, 186 and/or local load managers such as the LLM 151, collectively referred to as load managers, are configured to perform various predictive and control tasks described herein.", "Only one load manager is required within the system 100 to perform such tasks.", "When multiple load managers are present, such as the illustrated embodiment, the load managers may negotiate to select a master load manager, e.g.", "as described in U.S. patent application Ser.", "No.", "12/603,526 to Grohman, et al.", "(the '526 application), incorporated herein by reference in its entirety.", "In some embodiments described below the load controller 183 operates as a master load manager.", "In the discussion below reference to a load manager assumes it is a master load manager unless otherwise stated.", "Each appliance may report at least its instantaneous power consumption to the master load manager, e.g.", "the load manager 183.The reported power consumption may be an estimated value, such as a preset parameter retained by the reporting appliance.", "For example, the blower motor 115e may report nominal or expected power consumption under current working conditions, e.g.", "500 W. Alternatively or in combination, each appliance may report an actual current or voltage and current, to the master load manager.", "In various embodiments the (master) load manager 183 coordinates the operation of the various appliances.", "More specifically, the load manager 183 prioritizes the operation of the appliances 115 to meet a power consumption objective.", "In various embodiments the prioritization supports the objectives of 1) reducing peak power consumption of the various appliances within the structure 105, and 2) reducing variation of the total power consumed within the structure 105, as viewed from the power source.", "The total power consumed may be equivalently referred to herein and in the claims as aggregate power consumption.", "The priority of each appliance is dynamic, meaning the priority of each appliance 115 may change over time, for example, to reflect a change of its local environment, and hence that appliance's need to respond thereto.", "For example, outside air temperature (OAT) may increase, placing a greater cooling load appliances 115 associated with HVAC functions.", "The priority of one appliance 115 relative to the priority of another appliance 115 may also change dynamically as each appliance adjusts its priority.", "In some cases the priority of a particular appliance 115 is determined and/or stored locally by that appliance 115.For example, the LLM 151 may be configured to store a priority of the sump pump motor 115i, and may report the priority to other appliances via the communication network 180.The LLM 151 may further be configured to modify the priority of the sump pump motor 115i to reflect conditions of the sump pump motor 115i that are detected locally but not necessarily reported over the communication network 180.For example, as discussed further below the priority of the sump pump motor 115i may increase as a water level in a sump drained by the sump pump motor 115i increases.", "In another example priority of HVAC appliances may increase as a departure of an indoor air temperature (IAT) from a setpoint temperature increases.", "FIGS.", "3A-3D illustrate embodiments of priority functions that may be used by an appliance 115 of the disclosure.", "These functions are representative of prioritization functions that may be used by any of the appliances 115 in the system 100, and represent different design choices reflecting the role of the particular appliance 115.In these figures, the vertical axis represents the dynamic priority of the appliance 115.The horizontal axis represents a deviation from a desired operating setpoint, wherein a dashed vertical line represents a reference at which the appliance 115 is operating at a desired operating setpoint.", "Increasing distance to the right of the reference line indicates greater positive deviation ΔT from the operating setpoint, while deviation to the left indicates increasing negative deviation ΔT from the operating setpoint.", "It will be immediately apparent to one skilled in the pertinent art that the prioritization functions may be configured to increase a priority when the deviation from a setpoint is negative.", "The prioritization functions are illustrative and not exclusive of other prioritization functions within the scope of the disclosure.", "The shape of the functions can change significantly over time as a result of change of conditions, either external or internal to the device, and may be viewed as temporary (or instantaneous) snapshots of the prioritization functions at any given time.", "FIG.", "3A illustrates, e.g.", "an IAT setpoint SP associated with the conditioned space 190 at a particular instant of time when the HVAC system is cooling the space.", "The SP represents a temperature at a given time, as defined by the cooling schedule for the space, above which the outside unit 110 should operate to cool the conditioned space 190.A positive deviation of the priority occurs when the IAT is greater than the SP, and a negative deviation occurs when the IAT is less than the SP.", "In this example the priority is linearly related to the temperature deviation ΔT.", "FIG.", "3B illustrates a prioritization function ƒ1(ΔT) in which the priority increases linearly in proportion to the deviation ΔT of the IAT from the SP, up to a maximum priority, e.g.", "100%.", "For instance, if the temperature within the conditioned space 190 were to increase above the temperature setpoint for that zone, the priority of the outdoor unit 120 for allocation of power may increase in proportion to the deviation of the temperature from the setpoint.", "However, below the setpoint the priority remains constant.", "FIG.", "3C illustrates a prioritization function ƒ2(T) that increases linearly above SP until the temperature deviation reaches a critical value, e.g.", "a critical temperature difference ΔTc.", "Above ΔTc the priority is a maximum value, e.g.", "100%.", "The slope of the prioritization function, ƒ2′(T), is discontinuous at ΔTc.", "For example, the function ƒ2(T) may be used by the compressor 115k, for which ΔTc represents a temperature above which food within the refrigerator 170 spoils.", "Thus, immediate allocation of power to the refrigerator 170 may be required to avoid such spoilage.", "FIG.", "3D illustrates a prioritization function ƒ3(T) that increases nonlinearly above SP.", "The function ƒ3(T) is representative of embodiments in which an appliance 115 may respond “intelligently” to a deviation from a setpoint.", "In the current example, the function ƒ3(T) may reflect a nonlinear or subjective discomfort experienced by a person within the conditioned space 190.For instance if the temperature and the humidity within the conditioned space 190 increase simultaneously, the temperature perceived by an occupant may be nonlinear.", "The function ƒ3(T) may also reflect a temperature prediction received by the load manager 183 as discussed further below.", "The slope of the function ƒ3(T) is discontinuous at ΔTc.", "Each of the appliances 115 in the system 100 may be subject to a prioritization function such as those exemplified in FIG.", "3A-3D.", "The prioritization function may be physically embodied anywhere within the system 100.For instance, in some embodiments the load manager 183 may include control algorithms that include the prioritization function for any one or more of the appliances 115 in the system 100.In a more specific example, the oven/range 175, may report a local parameter such as a temperature setpoint and a current temperature to the load manager 183 from which the load manager 183 computes the priority of the oven/range 175.In another embodiment the temperature setpoint associated with an appliance 115, such as HVAC-related appliances, is entered at the load manager 183.The load manager 183 may compute the priority of such appliances from the entered values.", "In some embodiments, the prioritization function is physically embodied at the appliance 115 with which the prioritization function is associated.", "Thus, for example, the LLM 151 may include functionality to determine its priority level from a locally reported parameter such as water level.", "The LLM 151 may then report its priority to an arbitrator such as the load manager 183.FIG.", "4 illustrates an embodiment in which three appliances A1, A2, A3 each have an associated priority function.", "The appliance A1 has a priority P1=C1ΔT, where C1 is a coefficient that determines the sensitivity (slope) of the priority function.", "The second appliance A2 has a priority P2=C2ΔT.", "In the illustrated example C1>C2, such that the priority of A1 is more sensitive to ΔT than is the priority of A2.The sensitivity of the priority function need not be constant.", "The appliance A3 has a priority P3=C3ΔT when ΔT<9° F. (5° C.) and P3=100% when ΔT≥9°.", "C3 is less than both C1 and C2, indicating that A3 is less sensitive to ΔT until ΔT=9°.", "When ΔT>9°, C3 is greater than both C1 and C2 indicating that A3 is more sensitive to ΔT in this temperature difference range.", "However since the combined slope C3 is less than the slope of C1, appliance A1 actually reaches the maximum priority at a lower temperature drift than appliance A3 which underlines the complexity of different permutations possible.", "FIG.", "5 illustrates priority functions for each of a set of appliances A1, A2, A3, A4 in the time domain.", "Corresponding functions P1, P2, P3 and P4 describe historical priority up to current time T0.Corresponding functions P1*, P2*, P3* and P4* describe predicted priority after T0.A solid line segment denotes historical priority data, and a long-dash dotted line segment indicates the predicted priority.", "The value of each priority function is the instantaneous priority of the corresponding appliance at T0.Each appliance of the set may have an independent and unique operating setpoint.", "The operating setpoint may be, e.g., with respect to temperature, humidity, water level or time of day.", "Each appliance A1, A2, A3, A4 may have a different priority function, but embodiments are not so limited.", "For example, the appliances A1 and A2 may have a same priority function that results in a different instantaneous priority for these appliances because the appliances A1 and A2 operate under different conditions.", "Prioritization, or priority order, is the order of appliance priorities at a particular instant in time.", "The illustrated example shows several possible outcomes of prioritization of the set of appliances.", "At a time T−3 the priority order is P2>P1>P4>P3.At a time T−2, P1>P2>P4>P3, and at a time T−1, P2>P1>P3>P4.As seen in this example, the priority of a particular appliance is dynamic with respect to both its own priority and with respect to that appliance relative to the priority of the other appliances.", "Prioritization may be predicted prioritization when determined from predicted priority functions.", "For example, at a time T1 the predicted priority order is P2>P3>P1>P4.The priority P4 of the appliance A4 also illustrates an example of a feature referred to herein as intelligent prioritization.", "(See also FIG.", "3D and related discussion, supra.)", "The form of P4, illustratively a curve for which P4″ (the second derivative with respect to time) increases with increasing time, may reflect various computations the appliance A4 performs to determine its priority.", "As described further below, in some embodiments the appliance A4 may employ predictive load and/or cost models to compute its priority.", "In some embodiments the load manager 183 may determine the priority for each appliance in the system 100, including determining the priority of the appliance A4 to meet a system-level constraint such as maintaining an aggregate power load less than a maximum assigned to the system 100 by a supplying utility, or to take into account peak-period power pricing.", "Such predictive prioritization will in general yield a priority function with an arbitrary form.", "In an embodiment, an appliance may report its requested priority to the load manager 183 by a piecewise-linear function.", "For example, the priority function P4 may be reported by the appliance A4 as a piecewise-linear function 510, illustrated as short-dashed line segments.", "The function 510 may be communicated with fewer data points, thereby reducing the bandwidth on the communication network 180 used for such purposes.", "In various embodiments the appliances estimate their future priority function and report the estimate to the load manager 183.The load manager 183 may then determine a predicted priority order.", "In some cases one or more appliances may report a local environmental condition such as OAT and/or local IAT to the load manager 183 to support an estimate determined by the load manager 183.For example, the load manager 183 may predict a required load on an HVAC component based on the IAT and/or OAT, and determine the prioritization based on the priority function and predicted load of that component.", "The load manager 183 may arbitrate among various appliances to allocate power thereto given the level of criticality determined for each appliance from its associated prioritization function and, in some embodiments, the total power budget available.", "The load manager 183 is configured in various embodiments to allocate power to the appliances based on the current priority and current power consumption of each appliance.", "Allocation may be by way of an operating command configured to fully or partially enable or disable operation of the appliance.", "For example, at time T−3 in FIG.", "5, the load manager prioritizes operation of the appliances in the order A2, A1, A4, A3.In some cases the prioritization will have no effect on the operation the appliances.", "For example, when the aggregate power required to operate the appliances is less than a maximum permissible aggregate power assigned to the system 100, all the appliances may operate normally.", "On the other hand, if the aggregate power to fully operate all the appliances (A1 .", ".", ".", "A4 if the current example) exceeds the assigned power maximum, the load manager 183 may completely disable operation of the appliance A3.If the available power exceeds the power required to operate the remaining appliances, these appliances may operate normally.", "If the available power is insufficient, then the load manager may fully or partially disable operation of the appliance A4.In some embodiments the load manager 183 allocates power to the appliances 115 based on estimated future priority.", "For example, when an estimated future priority predicts the power requirement of a particular appliance will decline, the load manager 183 may allocate power to another appliance 115 earlier than would otherwise be the case.", "Conversely, if the estimated priority indicates the power requirement of the estimating appliance 115 will increase, the load manager 183 may defer allocating power to other appliances 115.In some embodiments the load manager 183 allocates power to the appliances 115 based on an integral of the historical or estimated priority functions.", "For example, the appliances 115 may have a priority ranking based on total power consumption over a past or future time range.", "The load manager 183 may rank the appliances 115 by past or future integrated power consumption.", "The ranked integrals of the estimated priority functions may result in a different ranking of the appliances 115 than would be the case for priority based on the instantaneous power consumption.", "The different ranking may be indicative of a future change of ranking based on instantaneous power consumption by the appliances 115.The load manager may anticipate this change by allocating power to the appliances 115 based on the integrated estimated priority functions.", "The integration period is not limited to any particular value, but at least a 5 minute period is expected to provide the desired benefit.", "In some embodiments the integration period may be about one hour to provide longer range power consumption average, while in other embodiments the integration period may be 12 or 24 hours to provide a time average reflective of significant portions of a day.", "In various embodiments, the load manager 183 considers all, or a selected subset of all possible combinations of the efficiency maps associated with concurrently operating appliances.", "The load manager 183 may determine a value that aggregates the priorities of the selected set of efficiency maps, and may select a combination efficiency maps that provides a minimum aggregated value.", "The aggregate value may be, e.g.", "a simple average of the priority values, or a weighted average to reflect any desired weighting.", "The aggregate value may be used as a proxy for the power consumed by the system 100 operating the appliances associated with the selected combination of efficiency maps.", "The minimum aggregate value may be determined over any desired time frame, e.g.", "1, 2, 12 or 24 hours.", "The load manager 183 may select the combination of appliances that corresponds to the selected set of efficiency maps that results in the minimum aggregate value.", "The power allocation provided by the load manager 183 may be partial or complete.", "For example, the load manager 183 may select full power operation for some appliances, partial power operation for another group of appliances, and zero power (e.g.", "appliances completely disabled) for yet another group of appliances.", "In an embodiment the load manager 183 limits the operating power of a variable speed stage motor to a nonzero value less than a maximum operating power of the motor.", "For example, the motor may drive a multi-stage compressor of an HVAC outdoor unit.", "By limiting the maximum power of the compressor, the load manager 183 may allow the HVAC system to continue to provide service, e.g.", "cooling, while limiting the instantaneous power consumed by the HVAC system.", "In other nonlimiting examples, the speed of a fan motor or a pump motor may be limited while allowing that motor to continue to provide the associated service.", "Such embodiments may be particularly useful to limit the aggregated power consumption of the system 100 while allowing services to remain active.", "In this manner the load manager 183 may operate the system 100 to achieve a targeted total power consumption over the selected time period.", "The target value may be imposed, e.g.", "by a homeowner to achieve energy economy, or by a utility to manage overall power consumption of a large number of power subscribers.", "In various embodiments the load manager 183 looks ahead to predicted conditions to determine the relative priorities of appliances 115.In an illustrative case, FIG.", "6 illustrates predicted OAT and a desired IAT for the conditioned space 190.The predicted outside air temperature may be obtained by the load manager 183, e.g.", "from a server via a wired or wireless internet connection.", "The desired IAT includes three segments.", "A segment 610 at 82° F. (˜28° C.) covers a period prior to T1.A segment 620 at 78° F. (˜26° C.) covers a period after T2.A segment 630 covers a transition period between T1 and T2 during which the load manager 183 may be programmed to reduce the IAT from 82° to 78°.", "The OAT is illustrated as increasing over the illustrated time period to a maximum value at about 100° F. (˜38° C.) and then falling.", "This profile may be representative of, e.g.", "the rise and fall of the OAT on a hot summer day.", "At any particular instant, the OAT curve represents a predicted OAT for a time range following that instant.", "The load manager 183 may use the predicted OAT to weight the priority of the HVAC-related appliances when determining anticipated power loading by the system 100.In some embodiments the load manager 183 may take into account the cost of energy in determining a priority weighting.", "For example a temperature segment 640 may reflect an IAT rise due to a setback program running on the load manager 183.The load manager 183 may project a rise of the IAT based on a predicted OAT.", "For example, the load manager 183 may be programmed to provide a setback temperature while the structure 105 is unoccupied.", "The load manager 183 may be prepared to allow the IAT to rise to 85° F. (˜29° C.) during a setback period.", "The load manager may be further configured to attain an IAT setpoint of 78° F. (˜26° C.) at time T2.Operating conventionally the load manager 183 might allow the IAT to follow a path described by the segment 640, in which the load manager 183 begins to reduce the IAT to a lower value beginning at T1.In contrast to conventional operation, in various embodiments the load manager 183 may take into account a cost function 650 when controlling the system 100.According to the cost function 650, the cost of the power received by the system 100 increases between T1 and T2.The load manager 183 may determine that the cost of reducing the IAT to 78° F. is lower if the load manager 183 limits the setback temperature to less than 85° F., begins reducing the IAT before T1, or both.", "In an illustrative example, a segment 660 shows the IAT for such an embodiment.", "(In this case it is possible that the total power consumed by the system 100 is greater following the segment 660 than by following the segment 640, though the cost to the energy subscriber may be lower.)", "The load manager may control the system 100 to follow the segment 660 by, e.g.", "elevating the priority of the appliances 115 associated with the HVAC functions of the system 100.This prioritization may include reducing the priority of another appliance to stay within a power budget.", "For example, the operation of the refrigerator 170 may be deferred as long as the temperature within the refrigerator does not rise excessively.", "The load manager 183 may effectively lower the priority of such optional appliances 115 during the peak pricing period to reduce the aggregate cost of operating the system 100.In some embodiments dynamic priority adjustment may include consideration of an estimated power associated with an estimated future priority.", "FIGS.", "7A and 7B illustrate an example of related priority and power consumption.", "FIG.", "7A illustrates a priority function 710, and FIG.", "7B illustrates a corresponding power function 720.In one aspect the power function 720 may be viewed as an estimate of the power required by the corresponding appliance to meet the demand implied by the priority function 710.Thus, for example, an appliance 115 or the load manager 183 may determine that the priority function 710 is associated with the power function 720, e.g.", "by a stored parameter or historical performance data.", "The appliance 115 or the load manager 183 may determine a piecewise linear approximation of one or both the functions 710 and 720m as exemplified by a function 730.The piecewise linear approximation may be used as previously described to reduce communication and/or storage resources.", "(See FIG.", "5.)", "In various embodiments the future priority and/or the future power requirement of an appliance may be determined by extrapolation from a number of the most recent data points of actual priority and/or power consumption associated with that appliance.", "Without limitation the number of previous data points may be five, but embodiments are not limited thereto.", "The extrapolation may be updated regularly, e.g.", "every 5-10 minutes in some embodiments.", "Extrapolation may be by well-known techniques of fitting a polynomial curve, e.g.", "a second order polynomial, to the historical data.", "In some cases the resulting fit will yield an approximately linear extrapolation, while in other cases the fit may have significant curvature.", "The load manager 183 may be configured to truncate the extrapolation when the predicted values do not reflect physically realistic operating conditions.", "In some embodiments one or more of the appliances 115 or load managers 183, 186 is configured to build a profile history.", "A profile history may include historical information regarding aspects of the performance of that or another device (e.g.", "an appliance or load manager) over a preceding period of time.", "For example, a profile history may include performance data for one week prior to the present time of operation.", "Performance data may include time of operation, power consumed by operation, zone of operation, cost of operations, and external data such as outside air temperature and humidity over the historical period.", "In an embodiment one or more of the appliances 115 or load managers 183, 186 is configured to select a combination of performance factors based on a historical weather record.", "For example, the weather of a current day of operation may be similar to the weather of a recent day of operation.", "Similarity may include temperature, humidity, time of highest temperature, or energy pricing at one or more times of the day.", "Thus, the system 100 may benefit from performance optimization determined under similar conditions of the earlier period.", "Performance optimization may include modifying the operating priority of one or more appliance from the value that appliance or those appliances would otherwise have absent consideration of the weather history.", "Such use of historical data does not preclude the further optimization of performance in the current operation.", "Performance optimization may include integration of a function that describes a performance characteristic.", "For example, a function may be determined that describes efficiency of operation over a range of temperatures.", "The load manager 183, e.g., may determine a figure of merit describing operation of the system 100 by integrating the function that describes the efficiency of operation of one or more appliances 115 in the temperature conditions of operation.", "The integration limits may define a particular time period of operation.", "Efficiency of operation may be expressed as an efficiency map.", "FIG.", "8 illustrates an example of an efficiency map 800, simplified for ease of visualization.", "In various embodiments the load manager 183 computes the efficiency map 800 for a plurality of appliances 115, and in some cases all of the appliances 115, in the system 100.The computation may take into account the various factors discussed herein that influence the power consumption associated with the operation of the appliances.", "A characteristic 810 describes a power metric, e.g.", "predicted power over the next 24 hours, as a function of a parameter space that includes, e.g.", "the predicted priorities of the appliance over the computation time window.", "The power characteristic 810 is expected to have a local minimum at some combination of performance variables.", "Efficiency may be with respect to, e.g., instantaneous power use or monetary cost of operation or average power use or monetary cost over any time period.", "Any of the appliances or load managers 183 may produce and/or locally store an efficiency map in local volatile or nonvolatile memory.", "An efficiency map may express efficiency in terms of one or more variables to which the efficiency is responsive.", "When only one variable is used, the efficiency map may be expressed as a plot of the efficiency vs. the one variable in an X-Y plot.", "When two variables are used, the efficiency map may appear as a response surface of the efficiency as a function of the two variables.", "The efficiency may be expressed as three or more variables as well, though visualization is typically more difficult.", "A forecast efficiency may be determined for a combination of variables as determined by the specific variable space of the model.", "A different efficiency map may pertain to each appliance, to each of the conditioned spaces 190, 195, or to a constellation of appliances 115.A constellation is a group of appliances configured to operate together as a cohesive unit, such as the compressor motor 115a, fan motor 115b and blower motor 115e operating as an HVAC system.", "In various embodiments, the load manager 183 considers all, or a selected subset of all possible combinations of the efficiency maps associated with concurrently operating appliances 115.The load manager 183 may determine a value that aggregates the priorities of the selected set of efficiency naps, and select a combination of efficiency maps that provides a minimum aggregated value.", "The aggregate value may be, e.g.", "a simple average of the priority values, or a weighted average to reflect any desired weighting.", "The aggregate value may be used as a proxy for the power consumed by the system 100 operating the appliances 115 associated with the selected combination of efficiency maps.", "The minimum aggregate value may be determined over any desired time frame, e.g.", "1, 2, 12 or 24 hours.", "The load manager 183 may select the combination of appliances 115 that corresponds to the selected set of efficiency maps that results in the minimum aggregate value.", "The power allocation provided by the load manager 183 may be partial or complete.", "For example, the load manager 183 may select full power operation for some appliances 115, partial power operation for another group of appliances 115, and zero power (e.g.", "appliances 115 completely disabled) for yet another group of appliances 115.In this manner the load manager 183 may operate the system 100 to achieve a targeted total power consumption over the selected time period.", "The target value may be imposed, e.g.", "by a homeowner to achieve energy economy, or by a utility to manage overall power consumption of a large number of power subscribers.", "In an embodiment, one or more of the appliances 115 may determine (e.g.", "via an instance of the local load manager 151) if that appliance 115 is competitive with the operation of another appliance 115 for efficiency of operation.", "For example, if the unit 110 is a heat pump system, the compressor motor 115a may obtain an efficiency map from the furnace 115f and compare the two maps.", "If the compressor motor 115a determines that the overall efficiency of the system 100 would be greater if the compressor 115a operates to heat the structure 105, instead of the furnace 115f, then the compressor motor 115a may reduce its own priority level below that of the furnace 115f to allow the furnace 115f to operate.", "Each of the appliances 115 may be configured to engage in such a prioritization dialog, in which the appliances 115 share efficiency information in the form of the efficiency maps to modify their priority levels to cooperatively increase the efficiency of the system 100.This cooperative negotiation may include operation of the load managers 183, 186 and/or one or more instances of the local load manager 151.For example the load managers 183, 186 may perform the efficiency map comparisons and assign priorities to the appliances 115 in the system 100, or mediate the communication of the appliances 115 to effect a negotiation dialog between the appliances 115.Each appliance 115 may employ one or more forecasts when modifying or evaluating its associated efficiency map.", "For example, a particular appliance 115 may receive a forecast of temperature, humidity or energy cost.", "The forecast may be for any future time, but the forecast over the time period of the efficiency managed by the appliance 115 may be most relevant.", "In some embodiments an appliance 115 is configured to respond to a query from another appliance 115 or one of the load managers 183, 186 by returning an efficiency map that reflects a predicted efficiency.", "For example, the load manager 183 may be programmed to change a control setpoint of the system 100 at a particular time of day, e.g.", "5:00 PM.", "At a time before 5:00 PM the load manager 183 may issue to each of the compressor motors 115a and 115c a request to return an efficiency map that describes the predicted efficiency of each compressor motors 115a and 115c at 5:00 PM.", "The compressor motors 115a and 115c may then obtain a forecast of temperature and humidity at 5:00 PM, update each respective efficiency map, and return the efficiency maps to the load manager 183.The load manager 183 may then prioritize operation of the compressor motors 115a and 115c, taking into consideration the efficiency maps returned by the compressor motors 115a and 115c.", "In some embodiments the efficiency map reflects a time range, such as a setback period or an evening period during which the structure 105 is occupied.", "In various embodiments described herein, it is an objective to manage the operation of the various appliances to reduce energy cost or total power consumed by the system 100 while maintaining a comfortable environment within the structure 105.The sharing of predictive efficiency maps among the various appliances and the load managers 183, 186 provides for dynamic optimization of the interrelated operation of the appliances 115 to achieve the objective of greater efficiency.", "In another example, the load manager 183 may iteratively determine a power allocation solution.", "The load manager 183 may acquire the predicted efficiency maps from at least some and preferably all of the appliances 115 and calculate a load balance of the appliances 115 based on predicted loads and efficiencies.", "The load manager then distributes to each appliance 115 a power allotment over time.", "Each appliance 115 may recalculate its efficiency map for its allocated power condition.", "The load manager 183 may then acquire the new efficiency maps, recalculate the power allotments and again distribute the power allotments to the appliances 115.This cycle may repeat until the difference of calculated aggregate load of the system 100 between successive iterations is minimized and falls below a predefined threshold.", "Such iterative operation may be a background process so that the load manager 183 constantly employs updated information, e.g.", "weather, energy cost, and demand patterns, to actively seek a minimum power consumption, or cost, while providing desired and essential services to the structure 100.Turning now to FIG.", "9, a method 900 of the disclosure presented, e.g.", "for manufacturing a network of appliances such as the system.", "100.The method 900 is described without limitation in terms of the previously described features, e.g.", "in FIGS.", "1-8.The steps of the method 900 may be performed in an order other than the illustrated order.", "In a step 910 a first appliance is configured to report a power consumption via a communication path.", "In a step 920 a second appliance is configured to operate dependent on the power consumption reported by the first appliance.", "The above embodiment may include a step 930.In the step 930 a load controller is configured to determine for the first and second appliances respective first and second operating priorities.", "The determining is based on the power consumption.", "The load controller is further configured to control the operation of the first and second appliances based on the operating priorities.", "In the above embodiment the load controller may determine the first or second priority based on a predicted outside air temperature.", "Some of the above embodiments may include a step 940 in which the load controller is further configured to 1) determine an efficiency map that characterizes a total power consumption of the first and second appliances; and 2) control the operation of the first and second appliances based on the efficiency map.", "In some of the above embodiments the load controller may consider a cost of the power in determining the operating priorities.", "In any of the above embodiments the first or second operating priority may be is determined to prevent the first and second appliances from exceeding a maximum aggregate power consumption.", "In any of the above embodiments at least one of the first and second appliances may be a heating, ventilating and air conditioning system component.", "In any of the above embodiments at least one of the first and second appliances may be a resistive load.", "Those skilled in the art to which this application relates will appreciate that other and further additions, deletions, substitutions and modifications may be made to the described embodiments." ] ]
Patent_15874228
[ [ "System and Method for Sterilization of Medical Instruments within a Hydrogen Peroxide Sterilization Process", "A system and method of sterilization for medical instruments within a hydrogen peroxide sterilization process is provided.", "A medical instrument is housed in a sterilization tray, wherein the sterilization tray is formed from polypropylene and a glass material.", "The medical instrument and sterilization tray are subjected to a hydrogen peroxide sterilant." ], [ "1.A method of manufacturing and using a sterilization tray comprising: combining a quantity of polypropylene with a glass material; injecting the combined quantity of polypropylene with glass material into a sheet form; thermoforming the sheet form of the combined quantity of polypropylene with glass material into a tray form, thereby providing a sterilization tray; and subjecting the sterilization tray to a hydrogen peroxide sterilant.", "2.The method of claim 1, further comprising: premixing the polypropylene and the glass material into a resin without the addition of copolymers prior to the injection molding.", "3.The method of claim 1, wherein the sterilization tray is formed from polypropylene and the glass material by injection molding the polypropylene and the glass material into a tray form.", "4.The method of claim 1, wherein the glass material further comprises glass spheres.", "5.The method of claim 1, wherein the sterilization tray includes up to 30% glass material.", "6.The method of claim 1, further comprising: subjecting the medical instrument and sterilization tray to a steam sterilization.", "7.The method of claim 1, wherein the glass material further comprises glass fibers.", "8.The method of claim 1, further comprising the step of subjecting the sterilization tray to an ethylene oxide sterilant." ], [ "<SOH> BACKGROUND OF THE DISCLOSURE <EOH>The sterilization of medical instruments and tools before, after, and sometimes during medical procedures is a foundation of modern health care, as it is imperative in preventing the spread of harmful contaminants.", "Commonly, medical instruments are held within sterilization trays which are then processed through a sterilization operation.", "The sterilization operation can include sterilization within an autoclave, which is a pressure chamber that subjects the medical instruments to high pressure saturated steam at approximately 250° F.-270° F. for a period of time.", "Other sterilization processes include the use of chemical sterilant or light-based sterilizing devices.", "Sterilization trays used within the medical industry are commonly manufactured from polyphenylsulfone (PPSU) often known by the brand name RADEL®.", "The PPSU utilizes an extrusion process combined with a thermoforming process or is injection molded from resin.", "These PPSU have proven successful in many types of sterilization processes, such as within the steam autoclave, but they have points of failure in low temperature sterilization processes.", "For example, low-temperature chemical sterilizing using hydrogen peroxide has become more commonplace when sterilizing medical instruments that cannot tolerate steam sterilization.", "When the PPSU is subjected to hydrogen peroxide sterilization, however, the hydrogen peroxide is absorbed and causes the PPSU to discolor and become brittle over time, which leads to tray failure, or worse, ineffective sterilization due to a drop in the concentration level of hydrogen peroxide in the sterilization chamber.", "Thus, a heretofore unaddressed need exists in the industry to address the aforementioned deficiencies and inadequacies." ], [ "<SOH> SUMMARY OF THE DISCLOSURE <EOH>Embodiments of the present disclosure provide a system and method for sterilization of medical instruments within a hydrogen peroxide sterilization process.", "Briefly described, in architecture, one embodiment of the method, among others, can be broadly summarized by the following steps: housing a medical instrument on a sterilization tray, wherein the sterilization tray is formed from polypropylene and a glass material; and subjecting the medical instrument and sterilization tray to a hydrogen peroxide sterilant.", "The sterilization tray may be formed from polypropylene and the glass material by first injection molding the polypropylene and the glass material into a sheet form and then thermoforming the sheet form of the polypropylene and the glass material into a tray form.", "In one of many alternatives, the sterilization tray may be formed from polypropylene and the glass material by injection molding the polypropylene and the glass material into a tray form.", "The present disclosure can also be viewed as providing methods of manufacturing and using a sterilization tray.", "In this regard, one embodiment of such a method, among others, can be broadly summarized by the following steps: combining a quantity of polypropylene with a glass material; injecting the combined quantity of polypropylene with glass material into a sheet form; thermoforming the sheet form of the combined quantity of polypropylene with glass material into a tray form, thereby providing a sterilization tray; and subjecting the sterilization tray to a hydrogen peroxide sterilant.", "Other systems, methods, features, and advantages of the present disclosure will be or become apparent to one with skill in the art upon examination of the following drawings and detailed description.", "It is intended that all such additional systems, methods, features, and advantages be included within this description, be within the scope of the present disclosure, and be protected by the accompanying claims." ], [ "CROSS REFERENCE TO RELATED APPLICATION This application is a divisional of U.S. patent application Ser.", "No.", "15/080,992, entitled, “System and Method for Sterilization of Medical Instruments within a Hydrogen Peroxide Sterilization Process” filed Mar.", "25, 2016, which itself claims benefit of U.S.", "Provisional Application Ser.", "No.", "62/149,032, entitled, “System and Method for Sterilization of Medical Instruments Within a Hydrogen Peroxide Sterilization Process” filed Apr.", "17, 2015 and U.S.", "Provisional Application Ser.", "No.", "62/166,994, entitled, “System and Method for Sterilization of Medical Instruments Within a Hydrogen Peroxide Sterilization Process” filed May 27, 2015, the entire disclosure of which is incorporated herein by reference.", "FIELD OF THE DISCLOSURE The present disclosure is generally related to sterilization of medical instruments and more particularly is related to a system and method for sterilization of medical instruments within a hydrogen peroxide sterilization process.", "BACKGROUND OF THE DISCLOSURE The sterilization of medical instruments and tools before, after, and sometimes during medical procedures is a foundation of modern health care, as it is imperative in preventing the spread of harmful contaminants.", "Commonly, medical instruments are held within sterilization trays which are then processed through a sterilization operation.", "The sterilization operation can include sterilization within an autoclave, which is a pressure chamber that subjects the medical instruments to high pressure saturated steam at approximately 250° F.-270° F. for a period of time.", "Other sterilization processes include the use of chemical sterilant or light-based sterilizing devices.", "Sterilization trays used within the medical industry are commonly manufactured from polyphenylsulfone (PPSU) often known by the brand name RADEL®.", "The PPSU utilizes an extrusion process combined with a thermoforming process or is injection molded from resin.", "These PPSU have proven successful in many types of sterilization processes, such as within the steam autoclave, but they have points of failure in low temperature sterilization processes.", "For example, low-temperature chemical sterilizing using hydrogen peroxide has become more commonplace when sterilizing medical instruments that cannot tolerate steam sterilization.", "When the PPSU is subjected to hydrogen peroxide sterilization, however, the hydrogen peroxide is absorbed and causes the PPSU to discolor and become brittle over time, which leads to tray failure, or worse, ineffective sterilization due to a drop in the concentration level of hydrogen peroxide in the sterilization chamber.", "Thus, a heretofore unaddressed need exists in the industry to address the aforementioned deficiencies and inadequacies.", "SUMMARY OF THE DISCLOSURE Embodiments of the present disclosure provide a system and method for sterilization of medical instruments within a hydrogen peroxide sterilization process.", "Briefly described, in architecture, one embodiment of the method, among others, can be broadly summarized by the following steps: housing a medical instrument on a sterilization tray, wherein the sterilization tray is formed from polypropylene and a glass material; and subjecting the medical instrument and sterilization tray to a hydrogen peroxide sterilant.", "The sterilization tray may be formed from polypropylene and the glass material by first injection molding the polypropylene and the glass material into a sheet form and then thermoforming the sheet form of the polypropylene and the glass material into a tray form.", "In one of many alternatives, the sterilization tray may be formed from polypropylene and the glass material by injection molding the polypropylene and the glass material into a tray form.", "The present disclosure can also be viewed as providing methods of manufacturing and using a sterilization tray.", "In this regard, one embodiment of such a method, among others, can be broadly summarized by the following steps: combining a quantity of polypropylene with a glass material; injecting the combined quantity of polypropylene with glass material into a sheet form; thermoforming the sheet form of the combined quantity of polypropylene with glass material into a tray form, thereby providing a sterilization tray; and subjecting the sterilization tray to a hydrogen peroxide sterilant.", "Other systems, methods, features, and advantages of the present disclosure will be or become apparent to one with skill in the art upon examination of the following drawings and detailed description.", "It is intended that all such additional systems, methods, features, and advantages be included within this description, be within the scope of the present disclosure, and be protected by the accompanying claims.", "BRIEF DESCRIPTION OF THE DRAWINGS Many aspects of the disclosure can be better understood with reference to the following drawings.", "The components in the drawings are not necessarily to scale, emphasis instead being placed upon clearly illustrating the principles of the present disclosure.", "Moreover, in the drawings, like reference numerals designate corresponding parts throughout the several views.", "FIG.", "1 is a schematic illustration of a method of sterilizing medical instruments within a hydrogen peroxide sterilization process, in accordance with a first exemplary embodiment of the present disclosure.", "FIG.", "2 is a schematic illustration of a method of manufacturing and using a sterilization tray, in accordance with a second exemplary embodiment of the present disclosure.", "FIG.", "3 is a schematic illustration of a method of manufacturing and using a sterilization tray, in accordance with the second exemplary embodiment of the present disclosure.", "DETAILED DESCRIPTION FIG.", "1 is a schematic illustration of a method of sterilizing medical instruments within a hydrogen peroxide sterilization process 10, in accordance with a first exemplary embodiment of the present disclosure.", "The method of sterilizing medical instruments within a hydrogen peroxide sterilization process 10, which may be referred to herein simply as ‘method 10’ includes housing a medical instrument 20 in a sterilization tray 30, wherein the sterilization tray is formed from polypropylene and a glass material.", "The medical instrument 20 and sterilization tray 30 are subjected to a hydrogen peroxide sterilant 40 within a hydrogen peroxide sterilization process 50.Unlike a hydrogen peroxide sterilization process used with conventional PPSU sterilization trays, which are prone to degrading after being subjected to hydrogen peroxide, it has been found that trays formed from polypropylene (PP) and a glass material, such as glass fibers, glass spheres, or a combination thereof, can prove to be successful in hydrogen peroxide sterilization.", "The combination of PP and the glass material resists penetration of the hydrogen peroxide into the surface of the tray, since the PP and glass material provide for a less porous surface than conventional PPSU and glass trays.", "Thus, while PPSU absorbs hydrogen peroxide in low-temperature, PP with glass does not.", "Accordingly, PP and glass material formed trays may be capable of long term, successful use with hydrogen peroxide sterilization.", "Further, the process described herein may, in some situations, be used with ethylene oxide or other chemical sterilants.", "FIG.", "2 is a schematic illustration of a method of manufacturing and using a sterilization tray 110, in accordance with a second exemplary embodiment of the present disclosure.", "The method of manufacturing and using a sterilization tray 110, which may be referred to herein simply as ‘method 110’ includes forming the medical sterilization tray 130 by injection molding a polypropylene (PP) 120 and a glass material 122 into a tray form.", "The PP 120 and the glass material 122 may be provided to an inlet 162 of an injection molding device 160.The PP 120 and glass material 122 may be pre-mixed into a resin 126, without the addition of copolymers, prior to being fed into the inlet 162 of the injection molding device 160.Inside the injection molding device 160, the combined resin may be injected into a mold having a tray-form shape, which may include any type of shape to house medical instruments.", "The resulting tray 130 may then be used to sterilize medical instruments within a low-temperature hydrogen peroxide sterilization device 150.The sterilization device 150 receives an input of hydrogen peroxide 140 which is applied to the tray 130 and the medical instruments thereon, and effectively sterilizes the instruments, as is known in the art.", "Alternatively, or in addition, the sterilization device 150 may receive an input of steam 144 for use in sterilization, and/or the sterilization device may receive an input of a chemical sterilant including, but not limited to an ethylene-oxide based sterilant 142.In comparison to PPSU which is commonly used in medical sterilization trays, PP has a higher melt flow rate than PPSU and therefore PP is often more successfully used in injection molding.", "It is noted that the glass material 122 may include a variety of types of glass fillers and other materials.", "Commonly, glass fibers, glass spheres, or a combination of glass fibers and spheres may be used with the PP.", "The glass filling material 122 may provide rigidity to the eventual tray 130, such that it can support medical instruments properly.", "Up to 30% of the sterilization tray material may be glass fiber and/or glass spheres.", "While other materials and fillers may be included, the use of EVAL®, EVOH resin and film (ethylene vinyl alcohol copolymer) may be restricted or fully omitted from the combined resin and the resulting tray 130.FIG.", "3 is a schematic illustration of a method of manufacturing and using a sterilization tray 110, in accordance with the second exemplary embodiment of the present disclosure.", "Similar to FIG.", "2, the method 110 includes forming the medical sterilization tray 130 by injection molding a PP 120 and a glass material 122.However, the method of FIG.", "3 includes further injection molding the PP 120 and the glass material 122 into a sheet form 124, first, and then thermoforming the sheet form 124 of the PP 120 and the glass material 122 into a tray form.", "In this process, the PP 120 and the glass material 122 may be provided to an inlet 162 of an injection molding device 160.The PP 120 and glass material 122 may be pre-mixed into a resin, without the addition of copolymers, prior to being fed into the inlet 162 of the injection molding device 160.Inside the injection molding device 160, the combined resin may be injected into a mold having a sheet form, e.g., a substantially planar sheet that is sized for thermoforming.", "Once cooled fully, the sheet form of the combined resin may be placed in a thermoforming device 180.Within the thermoforming device 180, the sheet form of the combined resin is heated to a pliable forming temperature and formed to a tray-shape in a mold, which may include any type of shape to house medical instruments.", "The tray-shape is trimmed to create a final medical sterilization tray 130, which may then be used to sterilize medical instruments within a low-temperature hydrogen peroxide sterilization device 150.The sterilization device 150 receives an input of hydrogen peroxide 140 which is applied to the tray 130 and the medical instruments thereon, and effectively sterilizes the instruments, as is known in the art.", "It has been found that thermoforming PP materials alone may result in non-usable products, since the PP is often incapable of withstanding the thermoforming process.", "The glass filling materials 122 may be used to properly thermoform the sheet-form of the combined resin by helping the sheet-form of the combined resin maintain uniformity in shape.", "In one example, it has been found that the combined use of glass fibers and glass spheres may provide substantial benefits in maintaining uniformity during the cool down process after thermoforming.", "It should be noted that any process descriptions or blocks in flow charts should be understood as representing modules, segments, or steps that include one or more instructions for implementing specific logical functions in the process, and alternate implementations are included within the scope of the present disclosure in which functions may be executed out of order from that shown or discussed, including substantially concurrently or in reverse order, depending on the functionality involved, as would be understood by those reasonably skilled in the art of the present disclosure.", "It should be emphasized that the above-described embodiments of the present disclosure, particularly, any “preferred” embodiments, are merely possible examples of implementations, merely set forth for a clear understanding of the principles of the disclosure.", "Many variations and modifications may be made to the above-described embodiment(s) of the disclosure without departing substantially from the spirit and principles of the disclosure.", "All such modifications and variations are intended to be included herein within the scope of this disclosure and the present disclosure and protected by the following claims." ] ]
Patent_15874230
[ [ "Double Paddle Mechanism for Pool Cleaner", "A pool cleaner including a paddle wheel mechanism positioned within a fluid path of the pool cleaner.", "The paddle wheel mechanism includes a housing that directs fluid from the fluid path into a first flow path through a first inlet and a second flow path through a second inlet, where the first flow path and the second flow path pass separately through the housing and recombine before an outlet portion.", "A paddle wheel shaft is supported by the housing, and a first paddle wheel and a second paddle wheel are supported by the paddle wheel shaft.", "The first paddle wheel is configured to rotate the paddle wheel shaft responsive to fluid directed across the first paddle wheel through the first flow path.", "The second paddle wheel is configured to rotate the paddle wheel shaft responsive to fluid directed across the second paddle wheel trough the second flow path." ], [ "1.A pool cleaner comprising: a paddle wheel mechanism positioned within a fluid path of the pool cleaner and including a housing with a first inlet, a second inlet, and an outlet portion, the housing directing fluid from the fluid path into a first flow path through the first inlet and a second flow path through the second inlet, the first flow path and the second flow path passing separately through the housing and recombining before the outlet portion; a paddle wheel shaft supported by the housing; a first paddle wheel supported by the paddle wheel shaft and positioned within the housing along the first flow path, the first paddle wheel configured to rotate the paddle wheel shaft responsive to fluid directed across the first paddle wheel through the first flow path; and a second paddle wheel supported by the paddle wheel shaft and positioned within the housing along the second flow path, the second paddle wheel configured to rotate the paddle wheel shaft responsive to fluid directed across the second paddle wheel through the second flow path.", "2.The pool cleaner of claim 1, wherein the first paddle wheel includes a different configuration than the second paddle wheel.", "3.The pool cleaner of claim 1, wherein the first paddle wheel includes a first plurality of paddle wheel blades and the second paddle wheel includes a second plurality of paddle wheel blades.", "4.The pool cleaner of claim 3, wherein the first plurality of paddle wheel blades and the second plurality of paddle wheel blades each include one or more curved paddle wheel blades.", "5.The pool cleaner of claim 3, wherein the second plurality of paddle wheel blades have a different geometry than the first plurality of paddle wheel blades.", "6.The pool cleaner of claim 3, wherein the first plurality of paddle wheel blades define a first radial clearance between one or more distal tips of the first plurality of paddle wheel blades and a first internal surface of the housing, and the second plurality of paddle wheel blades define a second radial clearance between one or more distal tips of the second plurality of paddle wheel blades and a second internal surface of the housing, the second radial clearance being larger than the first radial clearance.", "7.The pool cleaner of claim 3, wherein a first blade width for the first plurality of paddle wheel blades is smaller than a second blade width for the second plurality of paddle wheel blades.", "8.The pool cleaner of claim 3, wherein the first plurality of paddle wheel blades includes six paddle wheel blades and the second plurality of paddle wheel blades includes four paddle wheel blades.", "9.The pool cleaner of claim 1, further comprising a strainer positioned within the first flow path.", "10.The pool cleaner of claim 1, wherein the second flow path includes a larger cross-sectional flow area than the first flow path.", "11.The pool cleaner of claim 1, wherein the housing includes an upper housing coupled to a lower housing, wherein the upper housing includes the outlet portion and the lower housing includes the first inlet and the second inlet.", "12.The pool cleaner of claim 11, wherein the housing defines the first inlet offset from the second inlet.", "13.The pool cleaner of claim 1, wherein the second inlet is substantially aligned with the outlet.", "14.The pool cleaner of claim 1, wherein the first paddle wheel and the second paddle wheel power at least one component of the pool cleaner by kinetic energy harvested through rotation of the paddle wheel shaft.", "15.The pool cleaner of claim 1 and further comprising a pool cleaner housing, the paddle wheel mechanism being sized to fit within the pool cleaner housing.", "16.A method of operating a pool cleaner including a paddle wheel mechanism with a first inlet, a second inlet, and an outlet portion, a paddle wheel shaft, and a first paddle wheel and.", "a second paddle wheel each supported b the paddle wheel shaft, the method comprising: drawing fluid through a fluid path of the pool cleaner; directing debris-free fluid from the fluid path through the first inlet into a first flow path and across the first paddle wheel to rotate the paddle wheel shaft; directing debris-laden fluid from the fluid path through the second inlet into a second flow path and across the second paddle wheel to rotate the paddle wheel shaft; and recombining the first flow path and the second flow path before the outlet portion.", "17.The method of claim 16, wherein directing debris-free fluid includes straining fluid from the fluid path via a strainer at the first inlet.", "18.The method of claim 16 and further comprising providing a first clearance between distal tips of the second paddle wheel and an internal surface of the paddle wheel mechanism and a second clearance between distal tips of the first paddle wheel and the internal surface of the paddle wheel mechanism, the first clearance being larger than the second clearance to permit debris traveling along the second flow path to pass across the second paddle wheel.", "19.The method of claim 16 and further comprising driving at least one component of the pool cleaner using kinetic energy harvested by rotation of the paddle wheel shaft.", "20.The method of claim 16, wherein drawing fluid through the fluid path of the pool cleaner includes drawing fluid from a pool cleaner inlet, through the fluid path, to a pool cleaner outlet." ], [ "<SOH> BACKGROUND <EOH>Mechanical pool cleaners are typically classified as pressure-side cleaners or suction-side cleaners based on their connection to a pool pump.", "More specifically, suction-side pool cleaners are connected to a suction or inlet port of the pump, while pressure-side pool cleaners are connected to a pressure or outlet port of the pump.", "In both types, water is drawn or forced through the cleaner and mechanisms are provided to attempt to harvest energy from water movement through the cleaner in order to operate one or more functions of the cleaner (e.g., vacuuming, steering, etc.).", "With respect to suction-side pool cleaners, a turbine or paddle wheel may be provided within a water flow passage to harvest energy from the water flow.", "Generally, design aspects of the paddle wheel and related components are based on a tradeoff between performance and efficiency.", "For example, reducing the clearances between blades of the paddle wheel and the walls of the associated flow passage may increase efficiency by allowing the paddle wheel to harness more kinetic energy from the fluid flow.", "However, reduced clearance may detrimentally affect paddle wheel performance because debris may not be allowed to pass through the water flow passage, and/or may impede rotation of the paddle wheel.", "On the other hand, increasing the clearances may improve performance by allowing debris to pass through the passage without impeding the paddle wheel.", "In this instance, however, more fluid may flow through the larger clearances without providing kinetic energy to the paddle wheel, which may result in reduced efficiency/ One pool cleaning system includes a pool cleaner with a primary turbine and two secondary turbines/ The primary turbine is mounted to a primary shaft and is fed by a primary fluid inlet.", "Fluid flow from the primary fluid inlet causes the primary turbine to rotate, thereby causing movement of the pool cleaner via walking pods.", "The secondary turbines are separately mounted to secondary shafts that are distinct from the primary shaft, and are fed by a secondary fluid inlet.", "Fluid flow from the secondary fluid inlet causes the secondary turbines to rotate in order to provide torque to a suction hose.", "Among other drawbacks, the use of separate turbines on separate shafts may not appropriately address the handling of debris to optimize performance and efficiency.", "Another pool cleaning system includes a first turbine receiving fluid flow from an external flow generator to drive rotation of a drive shaft.", "Rotation of the drive shaft drives rotation of a second turbine, which acts as an internal flow generator to expel water from the system.", "A further pool cleaning system includes two distinct vortex chambers for generating a swirling pattern of fluid flow within the chambers.", "Two turbines of the same type (i.e., of the same shape and size) are provided, with one turbine being oriented in each chamber at a location that is removed from the direct flow of fluid through the chamber.", "Fluid flow from an inlet is equally divided between the two chambers, with the swirling flow pattern within the chambers driving rotation of the turbines.", "The turbines are supported by independent shafts, with one of the turbines providing motive power to a first drive wheel of the system and the other turbine providing motive power to a second drive wheel of the system.", "Among other drawbacks, removal of turbines from the direct flow path of a fluid flow may result in reduced system efficiency.", "Further, the use of two turbines of the same type may not assist in the handling of debris to optimize performance and efficiency." ], [ "<SOH> SUMMARY <EOH>Some embodiments provide a pool cleaner including a paddle wheel mechanism positioned within a fluid path of the pool cleaner.", "The paddle wheel mechanism includes a housing with a first inlet, a second inlet, and an outlet portion.", "The housing directs fluid from the fluid path into a first flow path through the first inlet and a second flow path through the second inlet, where the first flow path and the second flow path pass separately through the housing and recombine before the outlet portion.", "The pool cleaner also includes a paddle wheel shaft supported by the housing, a first paddle wheel supported by the paddle wheel shaft, and a second paddle wheel supported by the paddle wheel shaft.", "The first paddle wheel is positioned within the housing along the first flow path and is configured to rotate the paddle wheel shaft responsive to fluid directed across the first paddle wheel through the first flow path.", "The second paddle wheel is positioned within the housing along the second flow path and is configured to rotate the paddle wheel shaft responsive to fluid directed across the second paddle wheel through the second flow path.", "Other embodiments provide a method of operating a pool cleaner including a paddle wheel mechanism with a first inlet, a second inlet, and an outlet portion, a paddle wheel shaft, and a first paddle wheel and a second paddle wheel each supported by the paddle wheel shaft.", "The method includes drawing, fluid through a fluid path of the pool cleaner, directing debris-free fluid from the fluid path through the first inlet into a first flow path and across the first paddle wheel to rotate the paddle wheel shaft, and directing debris-laden fluid from the fluid path through the second inlet into a second flow path and across the second paddle wheel to rotate the paddle wheel shaft.", "The method also includes recombining the first flow path and the second flow path before the outlet portion." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "14/209,789 filed on Mar.", "13, 2014, which claims the benefit of U.S.s Provisional Patent Application No.", "61/780,558 filed on Mar.", "13, 2013, the entire contents of which are incorporated herein by reference.", "BACKGROUND Mechanical pool cleaners are typically classified as pressure-side cleaners or suction-side cleaners based on their connection to a pool pump.", "More specifically, suction-side pool cleaners are connected to a suction or inlet port of the pump, while pressure-side pool cleaners are connected to a pressure or outlet port of the pump.", "In both types, water is drawn or forced through the cleaner and mechanisms are provided to attempt to harvest energy from water movement through the cleaner in order to operate one or more functions of the cleaner (e.g., vacuuming, steering, etc.).", "With respect to suction-side pool cleaners, a turbine or paddle wheel may be provided within a water flow passage to harvest energy from the water flow.", "Generally, design aspects of the paddle wheel and related components are based on a tradeoff between performance and efficiency.", "For example, reducing the clearances between blades of the paddle wheel and the walls of the associated flow passage may increase efficiency by allowing the paddle wheel to harness more kinetic energy from the fluid flow.", "However, reduced clearance may detrimentally affect paddle wheel performance because debris may not be allowed to pass through the water flow passage, and/or may impede rotation of the paddle wheel.", "On the other hand, increasing the clearances may improve performance by allowing debris to pass through the passage without impeding the paddle wheel.", "In this instance, however, more fluid may flow through the larger clearances without providing kinetic energy to the paddle wheel, which may result in reduced efficiency/ One pool cleaning system includes a pool cleaner with a primary turbine and two secondary turbines/ The primary turbine is mounted to a primary shaft and is fed by a primary fluid inlet.", "Fluid flow from the primary fluid inlet causes the primary turbine to rotate, thereby causing movement of the pool cleaner via walking pods.", "The secondary turbines are separately mounted to secondary shafts that are distinct from the primary shaft, and are fed by a secondary fluid inlet.", "Fluid flow from the secondary fluid inlet causes the secondary turbines to rotate in order to provide torque to a suction hose.", "Among other drawbacks, the use of separate turbines on separate shafts may not appropriately address the handling of debris to optimize performance and efficiency.", "Another pool cleaning system includes a first turbine receiving fluid flow from an external flow generator to drive rotation of a drive shaft.", "Rotation of the drive shaft drives rotation of a second turbine, which acts as an internal flow generator to expel water from the system.", "A further pool cleaning system includes two distinct vortex chambers for generating a swirling pattern of fluid flow within the chambers.", "Two turbines of the same type (i.e., of the same shape and size) are provided, with one turbine being oriented in each chamber at a location that is removed from the direct flow of fluid through the chamber.", "Fluid flow from an inlet is equally divided between the two chambers, with the swirling flow pattern within the chambers driving rotation of the turbines.", "The turbines are supported by independent shafts, with one of the turbines providing motive power to a first drive wheel of the system and the other turbine providing motive power to a second drive wheel of the system.", "Among other drawbacks, removal of turbines from the direct flow path of a fluid flow may result in reduced system efficiency.", "Further, the use of two turbines of the same type may not assist in the handling of debris to optimize performance and efficiency.", "SUMMARY Some embodiments provide a pool cleaner including a paddle wheel mechanism positioned within a fluid path of the pool cleaner.", "The paddle wheel mechanism includes a housing with a first inlet, a second inlet, and an outlet portion.", "The housing directs fluid from the fluid path into a first flow path through the first inlet and a second flow path through the second inlet, where the first flow path and the second flow path pass separately through the housing and recombine before the outlet portion.", "The pool cleaner also includes a paddle wheel shaft supported by the housing, a first paddle wheel supported by the paddle wheel shaft, and a second paddle wheel supported by the paddle wheel shaft.", "The first paddle wheel is positioned within the housing along the first flow path and is configured to rotate the paddle wheel shaft responsive to fluid directed across the first paddle wheel through the first flow path.", "The second paddle wheel is positioned within the housing along the second flow path and is configured to rotate the paddle wheel shaft responsive to fluid directed across the second paddle wheel through the second flow path.", "Other embodiments provide a method of operating a pool cleaner including a paddle wheel mechanism with a first inlet, a second inlet, and an outlet portion, a paddle wheel shaft, and a first paddle wheel and a second paddle wheel each supported by the paddle wheel shaft.", "The method includes drawing, fluid through a fluid path of the pool cleaner, directing debris-free fluid from the fluid path through the first inlet into a first flow path and across the first paddle wheel to rotate the paddle wheel shaft, and directing debris-laden fluid from the fluid path through the second inlet into a second flow path and across the second paddle wheel to rotate the paddle wheel shaft.", "The method also includes recombining the first flow path and the second flow path before the outlet portion.", "DESCRIPTION OF THE DRAWINGS FIGS.", "1A and 1B are isometric views of a pool cleaner for use with a paddle wheel mechanism described herein; FIG.", "2 is an isometric view of a paddle wheel mechanism including a housing; FIG.", "3 is an isometric view of the paddle wheel mechanism of FIG.", "2 with an upper portion of the housing removed to show a paddle wheel shaft, a first paddle wheel, and a second paddle wheel; FIG.", "4 is an isometric view of the paddle wheel shaft, and the first and second paddle wheels of FIG.", "3 removed from the housing for clarity; and FIG.", "5 is an exploded view of the paddle wheel mechanism of FIG.", "2 depicting example fluid flow paths through the housing.", "DETAILED DESCRIPTION Before any embodiments of the invention are explained in detail, it is to be understood that the invention is not limited in its application to the details of construction and the arrangement of components set forth in the following description or illustrated in the following drawings.", "The invention is capable of other embodiments and of being practiced or of being carried out in various ways.", "Also, it is to be understood that the phraseology and terminology used herein is for the purpose of description and should not be regarded as limiting.", "The use of “including,” “comprising,” or “having” and variations thereof herein is meant to encompass the items listed thereafter and equivalents thereof as well as additional items.", "Unless specified or otherwise, the terms “mounted,” “connected,” “supported,” and “coupled” and variations thereof are used broadly and encompass both direct and indirect mountings, connections, supports, and couplings.", "Further, “connected” and “coupled” are not restricted to physical or mechanical connections or couplings.", "It will be understood that terms such as “upper,” “lower,” “top,” “bottom,” and the like may be used with respect to an orientation depicted in a particular figure and are not intended to limit the disclosure to a particular orientation.", "The following discussion is presented to enable a person skilled in the art to make and use embodiments of the invention.", "Various modifications to the illustrated embodiments will be readily apparent to those skilled in the art, and the generic principles herein can be applied to other embodiments and applications without departing from embodiments of the invention.", "Thus, embodiments of the invention are not intended to be limited to embodiments shown, but are to be accorded the widest scope consistent with the principles and features disclosed herein.", "The following detailed description is to be read with reference to the figures, in which like elements in different figures have like reference numerals.", "The figures, which are not necessarily to scale, depict selected embodiments and are not intended to limit the scope of embodiments of the invention.", "Skilled artisans will recognize the examples provided herein have many useful alternatives and fall within the scope of embodiments of the invention.", "Various types of suction-side (or other) swimming pool cleaners are operated using energy harvested from the flow of fluid drawn through them.", "More specifically, suction-side pool cleaners are connected to a suction side of a pool pump that causes fluid to be drawn along a fluid path within the pool cleaner.", "A paddle wheel mechanism positioned within the fluid path may accordingly be utilized to harvest energy from the fluid flow along the fluid path.", "As noted above, it may be useful to provide a paddle wheel mechanism for a pool cleaner that balances concerns of efficiency with other performance considerations.", "For example, it may be useful to provide a paddle wheel mechanism that harnesses kinetic energy with relatively high efficiency from a fluid flow, while also preventing debris from excessively interfering with performance of the system.", "In certain embodiments, such a paddle wheel mechanism may include a housing that directs fluid from a fluid path of the pool cleaner into two distinct flow paths.", "A first of the fluid flow paths may include a strainer or other device associated with the flow path to remove debris, while a second of the fluid flow paths may be defined by an opening sized to receive a relatively large amount of debris.", "A single paddle wheel shaft may support a first paddle wheel disposed within the first flow path, and also may support a second paddle wheel disposed within the second flow path.", "The first paddle wheel may rotate in response to fluid flow along the first flow path, and the second paddle wheel may rotate in response to fluid flow along the second flow path, with both the first and the second paddle wheel thereby providing rotational power to the paddle wheel shaft.", "The first paddle wheel may be configured to operate with relatively high efficiency within a relatively debris-free first fluid path, while the second paddle wheel may be configured to operate with relatively high performance in the second fluid path that is designed to accommodate a substantial amount of debris.", "In certain embodiments, the first paddle wheel may include a first plurality of blades with a different configuration than a second plurality of blades included on the second paddle wheel.", "For example, the first plurality of blades may include a greater (or lesser) number blades or exhibit a different geometry than the second plurality of blades.", "In certain embodiments, a clearance between a portion of the first plurality of blades and the housing may be different from a clearance between a portion the second plurality of blades and the housing.", "For example, the radial clearance between distal tips of the first plurality of blades and the housing may be smaller than the radial clearance between distal tips of the second plurality of blades and the housing.", "This sizing may allow the first plurality of blades to harness kinetic energy with relatively high efficiency, while also allowing debris to pass between the second plurality of blades and the housing in order to ensure a high level of system performance.", "Referring now to FIG.", "1, an example pool cleaner 10 is depicted, which may utilize a paddle wheel mechanism 12 (see, e.g., FIG.", "2) to harvest kinetic energy of fluid moving through the pool cleaner 10.The pool cleaner 10 may be configured as a suction-side pool cleaner, or as various other types of pool cleaners (e.g., a pressure-side pool cleaner) known in the art.", "The pool cleaner 10 generally includes a housing 14, which is designed to retain the paddle wheel mechanism 12, and opposing wheels 16, 18 associated with the housing 14.The pool cleaner 10 further includes in an inlet (not shown) disposed on a lower surface of the pool cleaner 10 that allows for fluid and/or debris to enter into and/or travel through the pool cleaner 10.The pool cleaner 10 also includes an outlet 20 provided in the form of a cylindrical connection extending from an upper portion of the housing 14, which is designed to interact with a hose (not shown) that transports debris and/or water to a pool filtering mechanism and/or collection device.", "In certain embodiments, rotation of the paddle wheel mechanism 12 may provide kinetic energy for driving wheels 16 and 18, and/or for various other features or components vacuuming).", "Referring to FIGS.", "2-4, the paddle wheel mechanism 12 is depicted, which is designed for handling debris and harvesting energy within the swimming pool cleaner 10.Referring in particular to FIG.", "2, the paddle wheel mechanism 12 generally includes a paddle wheel housing 30, and a paddle wheel assembly defined by a first paddle wheel 84 and a second paddle wheel 86.The paddle wheel housing 30 is defined by an upper housing portion 32 and a lower housing portion 34.The housing 30 is configured to be disposed inside of the pool cleaner housing 14 and to be disposed within a fluid path 50 of the pool cleaner 10.In one embodiment, the paddle wheel mechanism 12 is sized to fit within the housing 14 of the pool cleaner 10.In another embodiment, some portions of the housing 30 of the paddle wheel mechanism .12 are integral with portions of the housing 14 of the pool cleaner 10.In a further embodiment, portions of the housing 30 may be omitted.", "As depicted, the upper housing portion 32 is secured to the lower housing portion 34 by one or more screw-mount bodies 38, although various other attachment mechanisms may be utilized, including hinges, clasps, latches and the like.", "The upper housing portion 32 and lower housing portion 34 may be releasably joined to each other to provide access to internal components of the paddle wheel mechanism 12 during, for example, cleaning or maintenance.", "As shown in FIGS.", "2 and 3, the housing 30 includes shaft supports 76 on opposing sides thereof, each of which supports ends of a single paddle wheel shaft 78, described in more detail below.", "The upper housing portion 32 is defined by a substantially semi-circular lower section 32a that is integral with a conical member 32b that terminates at a cylindrical outlet portion 36.The conical member 32b is sized in a substantially similar manner to the lower section 32a adjacent thereto and continuously tapers inwardly until joining the cylindrical outlet portion 36.The conical member 32b is designed to accommodate a larger volume of fluid author debris than the cylindrical outlet portion 36.The cylindrical outlet portion 36 defines a substantially circular opening that is in communication with the outlet 20 of the pool cleaner 10.The upper housing portion 32 defines an exit flow path for fluid and/or debris that is traveling through the housing 30 to the outlet 20.The lower housing portion 34 is defined by a substantially semi-circular base 34a that includes a first inlet 52 and a second inlet 54 extending therefrom.", "The lower section 32a of the upper housing portion 32 and the base 34a of the lower housing portion 34 collectively define a compartment to hold the first and second paddle wheels 84, 86.The first inlet 52 is configured as an extended rectilinear duct defining a first inlet opening 56 and a first cross-sectional flow area.", "The second inlet 54 is configured as an extended rectilinear duct providing a second inlet opening 58 and a second, larger cross-sectional flow area, as compared to the first cross-sectional flow area of the first inlet 52.The first inlet 52 is generally configured to accept fluid, whereas the second inlet 54 is generally configured to accept debris and a portion of fluid.", "More specifically, fluid may enter both the first inlet 52 and the second inlet 54, but the second inlet 54 is designed to accept: relatively large amounts of debris, including debris sized larger than the first cross-sectional flow area of the first inlet 52.The first inlet 52 and the second inlet 54 protrude outwardly from the semi-circular base 34a of the lower housing portion 34 at substantially different orientations.", "In the embodiment depicted, the second inlet 54 protrudes outwardly from the semi-circular base 34a of the lower housing portion 34 along a direction that is substantially parallel to the cylindrical outlet portion 36 (e.g., along the same axis).", "The first inlet 52 protrudes outwardly from the semi-circular base 34a along a direction that is different from the orientation of the second inlet 54.In one embodiment, the first inlet 52 protrudes outwardly at art angle that is offset, or deviates by about 30 degrees from the direction of the second inlet 54.It will be understood that other configurations may be possible, including configurations in which the second inlet 54 protrudes in a direction that is not substantially parallel with the cylindrical outlet portion 36, configurations in which the first inlet 52 protrudes in a direction that deviates by greater or less than 30 degrees from the direction of the second inlet 54, and configurations in which the first inlet 52 and the second inlet 54 extend outwardly in approximately parallel directions with respect to each other.", "In certain embodiments, a strainer 66 provided in the form of a filter, a mesh, or another device configured to block the passage of debris, may be associated with the first inlet 52.As depicted, the strainer 66 is mounted at an end of the first inlet 52 to substantially cover the first inlet opening 56, which may be useful to allow for periodic cleaning or replacement of the strainer 66.In certain embodiments, however, the strainer 66 may be provided at one or more different locations within the first inlet 52.In other embodiments, a strainer 66 may not be employed and the inlet opening 56 may be otherwise protected or constrained to limit the passage of debris therein.", "The size of the inlet opening 56 in conjunction with the strainer 66 limit the amount and size of debris that is capable of entering the first inlet 52.More particularly, the strainer 66 and/or sizing of the inlet opening 56 are designed to provide a relatively debris-free stream of fluid across the first paddle wheel 84.For example, the inlet opening 56 may be configured to be small enough that debris of a particular size cannot pass through the inlet opening 56, or the inlet opening 56 may be oriented to receive fluid from a compartment or cavity (not shown) that is protected from debris.", "The first inlet 52 and the second inlet 54 are designed to receive a portion of fluid and/or debris defined by the fluid flow path 50 More specifically, the housing 30 may direct fluid from the fluid path 50, via the first and second inlets 52 and 54 into a first flow path 60 and a second flow path 62 within the housing 30.The flow paths 60 and 62 may pass separately through various portions of the housing 30 (as discussed in greater detail below), and may recombine into a single outlet flow path 64 through the outlet portion 36.Referring to FIG.", "3, the housing 30 further defines a first paddle wheel compartment 70 and a second paddle wheel compartment 72 designed to hold the first paddle wheel 84 and the second paddle wheel 86, respectively.", "The two compartments 70 and 72 extend into and between the lower housing portion 34 and the upper housing portion 32 (see, e.g., FIG.", "2), and are separated by an internal divider 74.The internal divider 74 may be configured as a plate (or plates) bounding the first paddle wheel compartment 70 at a surface 74a and bounding the second paddle wheel compartment 72 at an opposing surface 74b.", "By separating the two paddle wheel compartments 70 and 72, the internal divider 74 also serves to separate the first flow path 60 from the second flow path 62 within the housing 30.The first paddle wheel compartment 70 of the housing, 30 is defined, at least in part, by a curved interior surface 92, which may be designed to generally provide relatively small clearances for rotation of the first paddle wheel 84.For example, the interior surface 92 may be generally curved to follow the path traced by the radially outermost portions of the first paddle wheel 84, as discussed in greater detail below, with the interior surface 92 generally defining a relatively small clearance between outermost portions of the first paddle wheel 84 and the interior surface 92.The first paddle wheel compartment 70 is also defined by an internal surface 96 (e.g., a side wall) and the surface 74a of the divider 74, each of which may be designed to provide relatively small clearances for lateral features of the first paddle wheel 84.Similarly, the second paddle wheel compartment 72 of the housing 30 is defined, at least in part, by a curved interior surface 94, which may be designed to generally provide relatively small clearances for rotation of the second paddle wheel 86.For example, the interior surface 94 may be generally curved to follow the path traced by the radially outermost (or other) portions of the paddle wheel 86, as discussed in greater detail below, with the interior surface 94 generally defining a clearance between the outermost portions of the second paddle wheel 86 and the surface 94.The second paddle wheel compartment 72 is also defined by internal surface 98 (e.g., a side wall) and the surface 74b of the divider 74, each of which may be designed to provide relatively small clearances for lateral features of the paddle wheel 86.The first and second paddle wheel compartments 70, 72 are designed to receive the first and second paddle wheels 84 and 86, respectively, which are supported by a paddle wheel shaft 78.The paddle wheel shaft 78 is depicted as a single cylindrical shaft that extends through the first and second paddle wheels 84, 86 and interacts with the shaft supports 76, which allows the paddle wheel shaft 78 to turn freely within the housing 30.In the embodiment depicted, an interior end 80 of the paddle wheel shaft 78 is fully enclosed by the housing 30 and an exterior end 82 of the paddle wheel shaft 78 extends outside of the housing 30.In this way, through connection of various devices or mechanisms to the exterior end 82 of the shaft 78, rotation of the paddle wheel shaft 78 may be utilized to provide power to a drive mechanism or steering mechanism (not shown) of the pool cleaner 10.It will be understood that, in other embodiments, the paddle wheel shaft 78 may be mounted within the housing 30 for rotation in a variety of other known ways.", "For example, the shaft supports 76 may support one or more bearings (not shown), which in turn support the paddle wheel shaft 78, or the end 82 of the paddle wheel shaft 78 may not extend outside of the housing 30.Similarly, the paddle wheel shaft 78 may be a single-body shaft, may include two co-axial half-shafts, or may take a variety of other configurations.", "Further, in certain embodiments, the interior end 80 of the paddle wheel shaft 78 may also extend outside of the housing 30.As shown in FIGS.", "3 and 4, the paddle wheel shaft 78 supports both the first paddle wheel 84 and the second paddle wheel 86, with the first paddle wheel 84 rotating within the first paddle wheel compartment 70 and, the second paddle wheel 86 rotating within the second paddle wheel compartment 72.The first paddle wheel 84 includes a plurality of blades 88 that extend radially away from a base 110 and are mounted to (or integrally formed with) the paddle wheel shaft 78.The blades 88 are each defined by a curved member that is bounded by an exterior lateral edge 114, an interior lateral edge 116, and a distal tip 122.Likewise, the second paddle wheel 86 includes a plurality of blades 90 that extend radially away from a base 112 and are mounted to (or integrally formed with) the paddle wheel shaft 78.The blades 90 are each defined by a curved member that is bounded by an exterior lateral edge 118, an interior lateral edge 120, and a distal tip 124.In certain embodiments, the bases 110 and 112 are non-rotatably attached to the paddle wheel shaft 78, such that the rotation of each of paddle wheels 84 and 86 provides rotational power to the paddle wheel shaft 78.In the embodiment depicted, the paddle wheel blades 88 and 90 include a generally curved profile over the majority of their extension away from the paddle wheel shaft 78, in order to effectively harvest kinetic energy from passing fluid.", "It will be understood, however, that other configurations are possible, including those in which the blades 88 and/or 90 have straight profiles.", "As depicted in FIG.", "4, a width dimension W1 of the first paddle wheel blades 88 may be generally smaller than a width dimension W2 of the second paddle wheel blades 90.It will be understood, however, that other configurations are possible, including those in which the first-blade width dimension W1 is equal to or greater than the second-blade width dimension W2 In the embodiment depicted, the first paddle wheel 84 includes six blades 88 (some of which are hidden from view in the various figures), and the second paddle wheel 86 includes four blades 90.It will be understood, however, that in other embodiments the first paddle wheel 84 may include the same number of blades as the second paddle wheel 86 (e.g., in a configuration with six blades 88 and six blades 90, or with four blades 88 and four blades 90) or may include fewer blades than the second paddle wheel 86 (e.g., in a configuration with four blades 88 and six blades 90).", "Portions of the blades 88 and 90 may be separable, respectively, from the paddle wheel bases 110 and 112 at, respectively, joints 126 and 128.This may be useful, for example, in order to allow for relatively easy cleaning or maintenance of the first and second paddle wheels 84, 86, as well as to allow for customizability of the paddle wheels 84 and 86.For example, if a particular radial clearance is desired for blades 88 and a different radial clearance is desired for blades 90, a particular set of blades 88 may be selected and attached to the base 110 at the joint 126, and a particular set of blades 90 may be selected and attached to the base 112 at the joint 128.Similarly, the number of the blades 88 and 90, or various other aspects of the paddle wheels 84 and 86 may be similarly varied through selective attachment of particular blades 88 and 90 at, respectively, the joints 126 and 128.As noted above, various internal surfaces of the first and second paddle wheel compartments 70, 72 provide particular clearances with respect to various features of the first and second paddle wheels 84, 86.For example, the surfaces 96 and 74a within the first paddle wheel compartment 70 may provide a relatively small clearance, respectively, for the exterior lateral edges 114 and the interior lateral edges 116 of the paddle wheel blades 88 of the first paddle wheel 84.Similarly, the surfaces 98 and 74b within the second paddle wheel compartment 72 may provide a relatively small clearance, respectively, for the exterior lateral edges 118 and the interior lateral edges 120 of paddle wheel blades 90 of the second paddle wheel 86.In certain embodiments, different clearances may be provided for various features of the blades 88 of the first paddle wheel 84 than for various features of the blades 90 of the second paddle wheel 86.For example, a radial clearance between one or more distal tips 122 of the blades 88 and the interior surface 92 of the first paddle wheel compartment 70 may be somewhat smaller than a radial clearance between one or more distal tips 124 of the blades 90 and the interior surface 94 of the second paddle wheel compartment 72.Among other benefits, a larger gap may be provided between the blades 90 and the housing 30 for easier passage of debris past the second paddle wheel 86 and through the second paddle wheel compartment 72.This configuration may be useful, for example, in order to allow debris to be gathered by the pool cleaner 10 in a cleaning operation.", "As such, a particular radial clearance (or clearances) for the blades 90 may be selected based upon the type and size of debris expected to pass through the housing 30.Referring now to FIG.", "5, various aspects of the operation of the paddle wheel mechanism 12 are depicted.", "Fluid flowing along the fluid path 50 is directed by the housing 30 into the first and second flow paths 60, 62.A portion of the fluid from fluid flow path 50 is split into, the first flow path 60 and passes through the first inlet opening 56 and the strainer 66 such that debris is removed from the first flow path 60 before reaching the first paddle wheel compartment 70.As a result, fluid flowing along the first flow path 60 across the first paddle wheel 84 within the first compartment 70 may be relatively debris-free.", "Accordingly, relatively small clearances may be provided between the paddle wheel blades 88 and the interior surfaces of the first paddle wheel compartment 70 (i.e., because there is little to no debris flowing along the first flow path 60) and the first paddle wheel 84 may operate with relatively high efficiency.", "For example, the paddle wheel blades 88 may be configured such that the distal tips 122 of the blades 88 pass very closely along, or adjacent to, the interior surface 92 of the housing 30.Accordingly, when the fluid moving along the first flow path 60 causes the first paddle wheel 84 to rotate, the first paddle wheel 84 harvests a relatively high proportion of the kinetic energy of the fluid.", "In certain embodiments, a large number of blades 88 (e.g., six of the blades 88) may be provided in order to efficiently harvest the kinetic energy of the flow path 60.A portion of the fluid from fluid flow path 50 is split into the second flow path 62 and passes through the second inlet opening 58 to reach the second paddle wheel compartment 72.In contrast with the first flow path 60, fluid flowing along the second flow path 62 may not travel through a strainer or other similar mechanism, so fluid flowing along the second flow path 62 and through the second paddle wheel compartment 72 may include a relatively large amount of debris.", "Passage of debris through the housing 30 via the second flow path 62 may facilitate various cleaning operations by the pool cleaner 10, and, as noted above, a relatively large flow area may be provided along the second flow path 62 to accommodate the debris.", "To allow the debris-laden flow to pass across the second paddle wheel 86, however, without excessively detrimental effect on system performance, relatively large clearances may be provided between the paddle wheel blades 90 of the second paddle wheel 86 and the interior surfaces of the second paddle wheel compartment 72.For example, the paddle wheel blades 90 may be configured such that the distal tips 124 of the blades 90 trace a path that is substantially spaced from, or removed from, the interior surface 94 of housing 30.Accordingly, when the fluid moving along the second flow path 62 causes the second paddle wheel 86 to rotate, debris traveling along the second flow path 62 may pass between, the distal tips 124 and the interior surface 94 of the housing 30 without excessively impeding the rotation of the second paddle wheel 86.In certain embodiments, a small number of the blades 90 (e.g., four of the blades 90) may be provided, in order to further prevent the debris in the second flow path 62 from adversely affecting rotation of the second paddle wheel 86.Accordingly, in various configurations, the first paddle wheel 84 may be designed to provide a high level of efficiency and the second paddle wheel 86 may be designed to provide a high level of performance, even in a debris-laden flow.", "As such, the first paddle wheel 84 may serve as a primary power source for pool cleaner operation, and the second paddle wheel 86 may allow debris to pass through the housing 30 while also providing a secondary source of additional power.", "Both of the first and second paddle wheels 84, 86 may together provide rotational power to other components of the pool cleaner 10 due to rotation on a common shaft 78.Further, either of the first or second paddle wheels 84, 86 may assist the rotation of the other, as needed.", "For example, in the event that rotation of the second paddle wheel 86 is hindered by accumulating debris, the high efficiency rotation of the first paddle wheel 84 may provide additional power to rotate the second paddle wheel 86 in order to dislodge the accumulated debris and return the second paddle wheel 86 to a higher performance operation.", "It will be understood that certain embodiments may differ from the example configurations noted above.", "For example, in certain embodiments, the lower housing portion 34 may include a single inlet opening (not shown), with various internal features of the lower housing portion 34 directing fluid from single inlet into the first and second flow paths 60 and 62.Similarly, in certain embodiments, the upper housing portion 32 may include two outlet openings (not shown), with a first of the outlet openings providing an outlet for fluid from the first flow path 60 and a second of the outlet openings providing an outlet for fluid from the second flow path 62.In certain embodiments, one or both of the first and second inlets 52, 54 may include non-rectangular geometry, including circular, ovular, or other cross-sectional geometry.", "Likewise, one or both of the first and second inlets 52, 54 may include constant (e.g., FIG.", "2) or variable cross-sectional geometry.", "In certain embodiments, the flow area of the first inlet 52 may be equal to the flow area of the second inlet 54, or the flow area of the first inlet 52 may be larger than die flow area of the second inlet 54.In additional embodiments, two separate housings (not shown) may be provided.", "For example, a first of two housings may enclose the first paddle wheel 84, a second of the two housings may enclose the second paddle wheel 86, and a common shaft 78 for both paddle wheels 84 and 86 may extend between the two housings.", "In some embodiments, the blades 88 of the first paddle wheel 84 may extend a similar radial distance away from the paddle wheel shaft 78 (or the paddle wheel base 110) as the blades 90 of the second paddle wheel 86 extend away from the paddle wheel shaft 78 (or the paddle wheel base 112), but a different radial clearance may still be provided between internal surfaces of the housing 30 and, respectively, the distal tips 122 and 124 of the blades 88 and 90.For example, a wall of the housing 30 that includes the interior surface 92 may be thicker than a wall of the housing 30 that includes the interior surface 94.Accordingly, the interior surface 92 may be generally closer to the paddle wheel shaft 78 than is the interior surface 94, such that a smaller radial clearance is provided for the blades 88 of the first paddle wheel 84 than for the blades 90 of the second paddle wheel 86 even though the blades 88 and 90 may extend the same radial distance away from the shaft 78.It will be appreciated by those skilled in the art that while the invention has been described above in connection with particular embodiments and examples, the invention is not necessarily so limited, and that numerous other embodiments, examples, uses, modifications and departures from the embodiments, examples and uses are intended to be encompassed by the claims attached hereto.", "The entire disclosure of each patent and publication cited herein is incorporated by reference, as if each such patent or publication were individually incorporated by reference herein.", "Various features and advantages of the invention are set forth in the following claims." ] ]
Patent_15874231
[ [ "INTEGRATED VISUAL NOTIFICATION SYSTEM IN AN ACCESSORY DEVICE", "The described embodiments relate generally to an accessory device for a tablet device.", "The accessory device takes the form of a flexible screen protector that can be disposed over a display portion of the tablet device.", "Because the flexible screen protector covers the display of the tablet there is no visual way for the tablet to provide notifications to the user while the screen protector overlays it.", "By providing a data and power connection between the tablet and the accessory device, the processor of the tablet device can command illumination elements disposed in the accessory device to be illuminated in any of a number of illumination states.", "Each of the illumination states can be associated with an operating state of the tablet device thereby allowing the tablet device to visually communicate operating state information while the display is covered." ], [ "1.An accessory device for an electronic device that includes a display, the accessory device comprising: a body having a size and shape to cover the display, the body having an opaque portion and a transparent portion connected to the opaque portion, wherein the body covering the display causes the display to present visual information at a location corresponding to the transparent portion.", "2.The accessory device of claim 1, further comprising illumination elements embedded in the cover.", "3.The accessory device of claim 2, further comprising a window formed in the cover, wherein the illumination elements provide a notification of visual element presented on the display at a location corresponding to the window.", "4.The accessory device of claim 3, further comprising a transparent material that fills the window.", "5.The accessory device of claim 1, further comprising: a least a first segment that defines the opaque portion; and a second segment that defines the transparent portion, wherein the second segment defines an outer edge of the body.", "6.The accessory device of claim 1, further comprising a hinge that connects the body with the electronic device.", "7.The accessory device of claim 1, further comprising an electroluminescent panel carried by the cover, the electroluminescent panel having a shape in accordance with a notification, wherein a control signal from the electronic device to the body causes the electroluminescent panel to illuminate and provide the notification.", "8.An accessory device for an electronic device that includes a display, the accessory device comprising: a transparent body having a size and shape to cover the display, the transparent body having an opening that leads to the electronic device; and a hinge connected to the transparent body, wherein when the hinge is coupled with the electronic device, the hinge allows rotation of the transparent body with respect to the electronic device.", "9.The accessory device of claim 8, wherein the transparent body allow an input to be received by a touch sensor of the display.", "10.The accessory device of claim 8, further comprising an illumination panel embedded in the transparent body, the illumination panel capable of illuminating when a control signal generated by the electronic device is received by the transparent body.", "11.The accessory device of claim 10, wherein the illumination panel illuminates to define an illumination that defines a user notification.", "12.The accessory device of claim 8, wherein the transparent body comprises: a first segment; and a second segment; and a foldable region between the first segment and the second segment, wherein the foldable region allows the first segment to pivot relative to the second segment, and vice versa.", "13.The accessory device of claim 12, wherein the transparent body further comprises: a third segment; and a second foldable region between the second segment and the third segment, wherein the foldable region and the second foldable region allow the first segment, the second segment, and the third segment to form a triangular support structure.", "14.The accessory device of claim 8, wherein the hinge comprises a magnet capable of magnetically coupled with the electronic device.", "15.An accessory device for an electronic device that includes a display, the accessory device comprising: a cover having a size and shape to cover the display; and an electroluminescent panel carried by the cover, the electroluminescent panel having a shape in accordance with a notification, wherein a control signal from the electronic device to the cover causes the electroluminescent panel to illuminate and provide the notification.", "16.The accessory device of claim 15, further comprising illumination elements embedded in the cover, the illumination elements capable of illuminating when a control signal generated by the electronic device is received by the cover.", "17.The accessory device of claim 15, wherein the cover comprises an opening, and wherein when the cover overlays the display, the display present visual information in a location corresponding to the opening.", "18.The accessory device of claim 17, further comprising: a first segment that includes the opening; and a second segment that includes the electroluminescent panel, the second segment different from the first segment.", "19.The accessory device of claim 18, further comprising a third segment different from the first segment and the second segments, the third segment comprising illumination elements embedded in the third segment, the illumination elements capable of illuminating to form at least of a notification or a word.", "20.The accessory device of claim 15, wherein the shape includes at least one of an email notification, a calendar notification, or an application related notification." ], [ "<SOH> BACKGROUND <EOH>Recent advances in portable computing include the introduction of hand held electronic devices and computing platforms known generically as tablet devices.", "These devices can be used for any number of tasks including word processing, social media networking, video conferencing, and gaming.", "These tablet devices also generally include a large screen that can be susceptible to damage.", "Consequently many users choose to cover the display of tablet devices with some form of screen protector.", "Because the screen protector tends to mask information displayed on the screen it becomes difficult to present visual alerts or updates to a user on the status of any number of tasks or events without removing the screen protector.", "A user must generally wait until the protective cover is remove to receive any updates on events that have transpired since the device was last used.", "Therefore, what is desired is a way to alert a user of an event or change in status associated with the tablet device while the screen protector is covering the tablet screen." ], [ "<SOH> SUMMARY <EOH>This paper describes various embodiments that relate to an apparatus and method for providing a visual indication of an operating state of a tablet device to a user.", "In a first embodiment an accessory device is disclosed.", "The accessory device is configured to be detachably coupled to a host device having a display.", "The accessory device includes at least the following: (1) a flexible flap having a size and shape in accordance with the display of the host device, the flexible flap having both a first and second surface; (2) a number of illumination elements disposed across the flap in a first pattern; and (3) a connector configured to receive electrical power from an electrical distribution system of the host device and a control signal from a processor of the host device.", "The received control signal directs selected ones of the illumination elements to coordinate with each other to provide an illumination state.", "In another embodiment a method is disclosed.", "The method provides a visual notification to a user of a tablet device while a display of the tablet device is covered by an accessory device.", "The method includes at least the following steps: (1) receiving a control signal at the accessory device from a processor disposed within the tablet device through a communication channel between the tablet device and the accessory device, the accessory device having a flexible flap with a size and shape in accordance with the display of the tablet device; and (2) providing the visual notification corresponding to an operating state of the tablet device by directing selected ones of a number of illumination elements disposed across the flexible flap to coordinate with each other to provide an illumination state in accordance with the received control signal.", "In yet another embodiment an accessory device is disclosed.", "The accessory device includes at least the following: (1) a flexible flap having both a first and second surface; (2) a number of illumination elements disposed across the flap in a first pattern; and (3) a connector configured to receive electrical power and a control signal.", "The received control signal directs selected ones of the illumination elements to coordinate with each other to provide an illumination state.", "Other aspects and advantages of the invention will become apparent from the following detailed description taken in conjunction with the accompanying drawings which illustrate, by way of example, the principles of the described embodiments." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "15/275,259, filed Sep. 23, 2016, entitled “INTEGRATED VISUAL NOTIFICATION SYSTEM IN AN ACCESSORY DEVICE”, which is a continuation of U.S. application Ser.", "No.", "15/262,504, filed Sep. 12, 2016, entitled “INTEGRATED VISUAL NOTIFICATION SYSTEM IN AN ACCESSORY DEVICE”, issued Sep. 5, 2017 as U.S. Pat.", "No.", "9,754,463, which is a continuation of U.S. application Ser.", "No.", "14/694,977, filed Apr.", "23, 2015, entitled “INTEGRATED VISUAL NOTIFICATION SYSTEM IN AN ACCESSORY DEVICE”, issued Nov. 1, 2016 as U.S. Pat.", "No.", "9,483,921, which is continuation of U.S. application Ser.", "No.", "13/708,833, filed Dec. 7, 2012, entitled “INTEGRATED VISUAL NOTIFICATION SYSTEM IN AN ACCESSORY DEVICE”, issued Aug. 11, 2015 as U.S. Pat.", "No.", "9,104,371, the contents of which are incorporated herein by reference in its entirety for all purposes.", "FIELD The described embodiments relate generally to accessory devices for portable electronic devices.", "In particular methods for displaying status information of a portable device through an accessory is disclosed.", "BACKGROUND Recent advances in portable computing include the introduction of hand held electronic devices and computing platforms known generically as tablet devices.", "These devices can be used for any number of tasks including word processing, social media networking, video conferencing, and gaming.", "These tablet devices also generally include a large screen that can be susceptible to damage.", "Consequently many users choose to cover the display of tablet devices with some form of screen protector.", "Because the screen protector tends to mask information displayed on the screen it becomes difficult to present visual alerts or updates to a user on the status of any number of tasks or events without removing the screen protector.", "A user must generally wait until the protective cover is remove to receive any updates on events that have transpired since the device was last used.", "Therefore, what is desired is a way to alert a user of an event or change in status associated with the tablet device while the screen protector is covering the tablet screen.", "SUMMARY This paper describes various embodiments that relate to an apparatus and method for providing a visual indication of an operating state of a tablet device to a user.", "In a first embodiment an accessory device is disclosed.", "The accessory device is configured to be detachably coupled to a host device having a display.", "The accessory device includes at least the following: (1) a flexible flap having a size and shape in accordance with the display of the host device, the flexible flap having both a first and second surface; (2) a number of illumination elements disposed across the flap in a first pattern; and (3) a connector configured to receive electrical power from an electrical distribution system of the host device and a control signal from a processor of the host device.", "The received control signal directs selected ones of the illumination elements to coordinate with each other to provide an illumination state.", "In another embodiment a method is disclosed.", "The method provides a visual notification to a user of a tablet device while a display of the tablet device is covered by an accessory device.", "The method includes at least the following steps: (1) receiving a control signal at the accessory device from a processor disposed within the tablet device through a communication channel between the tablet device and the accessory device, the accessory device having a flexible flap with a size and shape in accordance with the display of the tablet device; and (2) providing the visual notification corresponding to an operating state of the tablet device by directing selected ones of a number of illumination elements disposed across the flexible flap to coordinate with each other to provide an illumination state in accordance with the received control signal.", "In yet another embodiment an accessory device is disclosed.", "The accessory device includes at least the following: (1) a flexible flap having both a first and second surface; (2) a number of illumination elements disposed across the flap in a first pattern; and (3) a connector configured to receive electrical power and a control signal.", "The received control signal directs selected ones of the illumination elements to coordinate with each other to provide an illumination state.", "Other aspects and advantages of the invention will become apparent from the following detailed description taken in conjunction with the accompanying drawings which illustrate, by way of example, the principles of the described embodiments.", "BRIEF DESCRIPTION OF THE DRAWINGS The embodiments will be readily understood by the following detailed description in conjunction with the accompanying drawings, wherein like reference numerals designate like structural elements, and in which: FIG.", "1A shows a perspective view of a tablet device with a wired connector implemented between the tablet device and an accessory device; FIG.", "1B shows perspective views of a tablet device with a flexible attached accessory device; FIG.", "2A shows a top perspective view of a tablet accessory device having a number of electroluminescent panels arranged across it; FIG.", "2B shows a perspective view of a tablet in an operational state having an accessory device with illumination elements augmenting a particular application; FIG.", "3A shows a top perspective view of a tablet accessory device having an array of light emitting diodes arranged across it; FIG.", "3B shows an alternate embodiment of the tablet accessory device depicted in FIG.", "3A; FIG.", "4 shows a top perspective view of a tablet accessory device having translucent portions; FIG.", "5 shows a perspective view of an accessory device having a combination of different types of lighting elements; FIG.", "6 shows a perspective view of a narrower accessory device including only three segments; and FIG.", "7 shows a block diagram describing a process for alerting a user through an accessory device of an operating state of a host device.", "DETAILED DESCRIPTION Representative applications of methods and apparatus according to the present application are described in this section.", "These examples are being provided solely to add context and aid in the understanding of the described embodiments.", "It will thus be apparent to one skilled in the art that the described embodiments may be practiced without some or all of these specific details.", "In other instances, well known process steps have not been described in detail in order to avoid unnecessarily obscuring the described embodiments.", "Other applications are possible, such that the following examples should not be taken as limiting.", "In the following detailed description, references are made to the accompanying drawings, which form a part of the description and in which are shown, by way of illustration, specific embodiments in accordance with the described embodiments.", "Although these embodiments are described in sufficient detail to enable one skilled in the art to practice the described embodiments, it is understood that these examples are not limiting; such that other embodiments may be used, and changes may be made without departing from the spirit and scope of the described embodiments.", "Accessories for tablet devices have become quite common.", "Today typical tablet accessories are passive in nature, the majority of which simply function to protect the screen, or perhaps support the tablet in some specific orientation.", "Although some devices such as Bluetooth headsets and keyboards do have limited interactive capability the majority of accessories are limited to more basic, generally passive tasks.", "These accessories can be improved by including at least some of the following features: (1) a power source; and (2) a communications protocol.", "An active communication protocol between an accessory and a tablet device can be accomplished either wirelessly or through a wired data connection.", "For example, a wireless data connection utilizing the 5 GHz 802.11n protocol can provide sufficient data transmission bandwidth to transmit a high quality video stream along the lines of NTSC 1080p 30 fps video.", "The accessory can alternatively or additionally be electrically connected to the tablet device using any number of established standards such as DisplayPort™, mini DisplayPort™, DVI, and Thunderbolt™.", "A custom wireless or wired protocol is also certainly possible.", "In one specific embodiment an accessory device taking the form of a flexible flap can be configured with a number of illumination elements.", "The flexible flap is operable to inform a user of a tablet device of changes in operating states when the display of the tablet device is covered.", "The flexible flap itself can cover the display acting as a protective layer when the tablet device is not in active use by a user.", "The illumination elements can be any low power lighting elements thin enough to fit within the flexible flap, such as for example light emitting diodes or electroluminescent panels.", "A processor located within the tablet device can be configured to control the illumination elements.", "The processor of the tablet device can be in communication with the flexible flap by way of a connector element that electrically couples the two devices.", "That same connector element can be used to transfer power from the tablet device to the flexible flap.", "The tablet device only needs to provide power to the flexible flap when the processor through a control signal commands illumination of at least one of the illumination elements.", "The illumination of select ones of the illumination elements constitutes an illumination state of the cover alerting the user to any of a number of pre-defined operating states of the tablet device.", "In some cases the illumination states can be human readable.", "For example, the illumination elements can form recognizable words or symbols.", "In other cases a series of lights can be understood by a user to signify a specific operating state.", "In another embodiment an accessory device taking the form of a flexible flap can be configured with translucent portions allowing light provided by a display of a host device to shine through the flexible flap.", "In one specific embodiment the host device can be a tablet device having the display take up a substantial portion of one surface of the tablet device.", "Since the display of the tablet device performs all of the illuminating in this particular embodiment a data and power connection / link need not be configured between the accessory device and the host device.", "Translucent portions of the flexible flap can take on different shapes and be disposed in different portions of the flexible flap, such that illumination of each different portion can signify a different meaning.", "Discrete portions of the display can be illuminated with different shapes and colors corresponding to the translucent portions of the flexible flap.", "In some cases the discrete displayed portions can include words.", "Since the display of the tablet device can generally produce any of a wide number of colors and symbols a single transparent portion of the accessory device allows a user to view detailed information from the display of the tablet device representing any of a number of different operating states.", "Each different color and/or shape/symbol can correspond to different operating states of the tablet device.", "It should be noted that the opacity of the translucent portions can vary widely in accordance with the lighting effect desired by a designer of the accessory device.", "Various embodiments of an accessory device suitable for use with a host device are discussed below with reference to FIGS.", "1A-7.However, those skilled in the art will readily appreciate that the detailed description given herein with respect to these figures is for explanatory purposes as the full extent of the embodiments goes beyond these limited descriptions.", "In one embodiment a customized connector that passes both data and power can allow for a simple connection between two devices.", "For example a connector similar to the MagSafe® connector can be integrated with an auxiliary connector which passes data to an accessory device.", "FIG.", "1A shows arrangement 100 in accordance with an embodiment showing connector 102 that can be used to connect tablet device 104 and accessory device 106.Connector 102 can be configured as shown in close up view 108 with a number of separate channels, allowing the power and data transfer lines to traverse separate channels.", "It should be noted that many different types of connectors can be used to put the two devices in communication and the depicted connector should not be construed as limiting.", "A physical connector 102 would eliminate the need for a wireless data transmitter in the cover and would simplify electrical and data connections between the two devices.", "A wired data connection also removes security concerns associated with wireless communication protocols.", "However, it should be noted that in some embodiments there is no connector 102.In other embodiments a connection can be established by way of a power and/or data cable in lieu of the magnetic coupling depicted.", "Data transfer between accessory device 106 and tablet device 104 can also be accomplished by a wireless communication protocol.", "In some embodiments described later in this application no data or power connection needs to be made at all.", "Now that the electrical and data connection solutions have been discussed the following representative embodiments will include power and data connections between the accessory device and tablet as required.", "Magnetic attraction areas 110 can be used to magnetically attach accessory device 106 and tablet device 104.In a specific embodiment, magnetic attachment areas 110 can magnetically attach to magnetic elements (not shown) within hinge 112.Hinge 112 can be pivotally connected to accessory 106.In this way, accessory 106 can be configured in either an open or closed configuration with respect to tablet device 104.The magnetic attraction between magnetic attachment areas 110 and the magnetic elements in hinge 112 can be such that electronic device 104 and accessory device 106 attach to each other in a preferred alignment.", "For example, the preferred alignment can assure that connector 102 aligns and mates with a corresponding receptor (not shown) on hinge 112.In this way, the user of tablet device 104 can simply place accessory 106 and tablet device 104 within proximity distance dmag to each other such that the magnetic attraction between magnetic attachment area 110 and the magnetic elements in hinge 112 cause tablet device 104 and accessory device 106 to attach to each other with a high degree of confidence such that a proper mechanical and electrical connection can be made.", "In addition to transmitting power and information from the tablet device to the accessory device, in some embodiments the accessory device can be configured to transfer data from the accessory device to the tablet device.", "In some embodiments information transmitted to the tablet device can include information about what features that particular accessory device includes, allowing the tablet to know what types of commands can be received and how those commands will be interpreted.", "This information can for example allow applications to provide additional functionality corresponding to the features available in the attached accessory device.", "In other embodiments data transmission can be only from the tablet device to the accessory device in which case a user can enter accessory identification information through a graphical user interface provided by the tablet device.", "In this way the tablet device can be configured to have uni-directional communication with the accessory device, providing a control signal to the accessory device that in some embodiments dictates which features of the accessory device should be actuated at a given time.", "FIG.", "1B shows a perspective view of tablet device 104 with an attached accessory device 106.In the described embodiment, accessory device 106 can be used to both protect as well as provide functional support features for tablet device 104.Accessory device 106 can bend and flex as depicted allowing it to assume a convenient shape for a user of tablet device 104 to which it is attached.", "FIG.", "2A shows a top perspective view of tablet accessory device 200 having a number of electroluminescent (EL) panels arranged across it.", "In some embodiments the EL panels can be built from for example active matrix electroluminescence (AMEL) technology allowing for low power usage, and relatively lightweight.", "Alternatively, thin film electroluminescent (TFEL) display panels can also be used.", "A tablet device can be configured to supply both power and control signals to the accessory device as described in conjunction with FIG.", "1 for controlling and powering the EL panels of the accessory device.", "In one embodiment the tablet device can direct the tablet to illuminate EL panel 202 of accessory device 200.In some embodiments EL panel 202 can be configured to display any of a number of different colors.", "The control signal passed from the tablet device to the accessory device directing illumination of EL panel 202 can also include a call for a particular color that the EL panel should assume.", "In some embodiments illumination of a particular number or configuration of EL panels can be used to alert a user of the tablet device of the status of a certain event or application.", "For example, EL panels 202-214 can be configured to each light up red when the processor of the tablet device detects an event with a high enough priority.", "In some embodiments EL panels 202-214 can be disposed on the surface of accessory device 200 while in other embodiments EL panels 202-214 can be disposed within accessory device 200.In such a case accessory device 200 can have a translucent portion overlaying the EL panels or in other embodiments the EL panels can shine through a thin layer of fabric or plastic, giving the accessory device more of a soft glowing look.", "In some embodiments a brief animation can be configured across EL panels 202-214.For example, EL panel 202 can be illuminated first followed by EL panel 206 then followed sequentially by EL panels 210 and 214.In some cases the EL panels can be configured to turn on and off.", "While a few specific examples have been given, many other combinations and permutations of lighting of the illustrated EL panels are certainly possible and within the scope of the described embodiments.", "EL panels 202-214 are depicted as being arranged across a segment 216 of accessory device 200, with each EL panel sharing a common rectangular shape.", "However, it should be noted that EL panels 202-214 can be spread across any of segments 216-222 and take on any number of varying shapes and sizes.", "For example, in some embodiments additional undepicted EL panels can be associated with accessory device 200 which can take the shape of letters that more specifically alert a user to what kind of alert or change in status has occurred or is occurring.", "In other embodiments the location of an illuminated EL panel can correspond to the type of application generating the alert.", "For example, an illuminated EL panel arranged on segment 218 can signify receipt of an email or text message, while an illuminated EL panel arranged on segment 220 can represent status changes in a turn-based video game application.", "In other embodiments the location of illuminated EL panels can correspond to priority of the status change or alert.", "For example, an illuminated EL panel disposed on segment 222 can have much lower priority than an illuminated panel disposed on segment 218.It should be noted that in some embodiments an associated tablet device can be configured with a sensor, for example a Hall Effect sensor to determine when accessory device 200 is covering the display of the tablet device.", "In some cases the tablet device can send the accessory device a signal by way of a control signal to disable all accessory device lighting when the tablet device no longer detects the presence of the accessory device across the display of the tablet device.", "For example, the accessory device can have a magnet embedded within it that can be sensed by the Hall Effect sensor of the tablet device only when the accessory device covers the tablet device.", "In this way the lighting can be disabled after uncovering the display of the tablet.", "It should also be noted that in some cases as will be discussed below, lighting can still be desirable while actively operating the tablet device.", "FIG.", "2B shows accessory device 200 configured to support tablet device 250 in a comfortable typing or viewing position.", "In this embodiment segment 222 has EL panels 224-232 arranged across it.", "In the depicted embodiment EL panels 224-232 can be visible from both an inner surface of accessory device 200 and an outer surface of accessory device 200.This can be accomplished by embedding EL panels 224-232 within accessory device 200, thereby allowing light to shine out from both the inner and outer surfaces.", "Opacity of the overlaying accessory device material can be varied in accordance with what type of look is desired.", "In some embodiments overlying material of the accessory device can be completely transparent while in other embodiments the overlying material can be substantially opaque allowing only a faint glow to shine through either of the surfaces of accessory device 200.When EL panels 224-232 are visible as depicted in FIG.", "2B EL panels 224-232 can be used in conjunction with an application configured to utilize the panels.", "In one embodiment EL panels 224-232 can be configured as a countdown timer.", "All of EL panels 224-232 can be configured to be illuminated at the start of the timer and then sequentially turned off as the countdown timer approaches zero.", "Any number of possible illumination element combinations is possible and can be implemented by either first or even third party application developers to augment performance or an overall experience associated with the application running on the tablet device.", "FIG.", "3A shows a top perspective view of tablet accessory device 300 having a number of light emitting diodes (LED) arranged across it.", "Tablet accessory device 300 can have a number of segments 302-308.Segments 302-308 can be rigid and can bend and flex with respect to one another across flexible portions 310-314 of accessory device 300.Each of segments 302 can have a number of LEDs 316 arranged across it.", "As depicted the LEDs are arranged in a regular array configuration, but it should be noted that any geometric configuration of the LEDs is possible.", "Each LED 316 can be either a single color LED or can be configured as an RGB LED, the RGB LEDs allowing almost any color to be displayed by each of the LEDs.", "By illuminating select LEDs 316 messages can be displayed across an outer surface of accessory device 300, the messages in some embodiments telling a user the exact nature of the alert or status update.", "As a density of LEDs 316 increases so does the ability of accessory device 300 to provide higher resolution information to a user of the tablet device while the tablet device display is covered.", "An exterior button disposed on either a surface of the tablet device or on the accessory device itself can be used to acknowledge or clear messages displayed by the accessory device, thereby minimizing power usage of the accessory device.", "For example, the iPad® designed by Apple Inc. of Cupertino, Calif. has a volume button that can in one embodiment be configured to clear the notification or in some embodiments to scroll through a number of different notifications displayable across tablet accessory device 300.In one specific embodiment actuation of the up portion of the volume button can dismiss a notification while actuation of the down portion of the volume button can allow a user to scroll through previously posted notifications representing specific operating states of the tablet device.", "As discussed previously with regards to the EL panels, LEDs 316 can be disposed either on a surface portion of accessory device 300 or laminated within segments 302-308, thereby providing additional protection for the embedded LEDs 316 and in some embodiments partially obscuring LEDs 316.In some embodiments LEDs 316 can be substantially invisible until being placed into an illuminated state at which point light emanating from LEDs 316 can shine through one or both surfaces of accessory device 300.In addition to displaying messages LEDs 316 can be illuminated in a manner that forms human readable symbols, such as for example an envelope image signifying receipt of an email, or even a thundercloud signifying approach of an imminent storm.", "FIG.", "3B shows a top perspective view of tablet accessory device 350.Tablet accessory device 350 has three segments, segments 352-356.Segment 352 has an alternative arrangement of light emitting diodes (LEDs) 358.LEDs 358 disposed on segment 352 are offset from one another providing an alternative arrangement capable of presenting different patterns than would be otherwise possible with a grid pattern of the same LED 358 density.", "Segment 354 has a much lower density of LEDs 358 than segment 352, allowing presentation of illumination states including diagonal stripes.", "Segment 356 includes yet another layout of LEDs 358 where the LEDs are arranged in cross patterns.", "Such a configuration allows the display or a cross or rectangle corners or even a series of diagonal stripes that can be configured to complement diagonal stripes displayed on segment 354 in some illumination states.", "It should be noted that while accessory devices having 3 and 4 segments have been illustrated, other numbers of segments are certainly possible, allowing in one embodiment a user a more flexible cover with greater segments or in another embodiment a less flexible cover with fewer segments.", "Either can be desirable depending on a contemplated use of the accessory device.", "FIG.", "4 shows a top perspective view of tablet accessory device 400 having a segment 402 with at least one region of transparency 404.Region 404 of accessory device 400 can be at least partially transparent, allowing an underlying display associated with the tablet device to shine messages or alerts through accessory device 400.In this way accessory device 400 itself can be completely passive removing any need for accessory device 400 to be provided with power or electrical commands.", "Transparency region 404 can be configured to have widely varying opacity.", "In the depicted embodiment when the underlying display of the tablet device lights up region 406 of transparency region 404, the emitted light can pass through region 406 of transparency region 404.It will be appreciate than one or more of regions 408, 410, 412, 414, 416, and 418 may be illuminated via region the tablet device in a manner similar to that of region 406.When that overlying portion only allows light to penetrate the accessory device in a specific locations the emitted light can be in the form of an illuminated picture or words.", "Coloring of the emitted light can be influenced by materials embedded within the accessory device and/or an original hue of the light emitted from the tablet's display.", "In other embodiments where transparency region 404 is completely or least substantially transparent, region 406 of the display of the tablet device can simply show text or images clearly explaining the nature of the notification.", "It should be noted that in configurations where accessory device 400 is not in communication with an associated tablet device, the tablet device can be configured to receive a user input detailing features of the accessory device.", "In one embodiment this can be as simple as entering a serial number associated with the accessory device into the tablet device thereby alerting the tablet device to any and all features associated with a specific model of accessory device.", "For example, a line of accessory devices with a wide variety of translucent region locations can be developed.", "By entering the serial number the tablet device can be aware of the location, shape, opacity, and orientation of all transparent regions arranged on the accessory device.", "It should be noted that the embodiments of FIG.", "4 can be combined with the embodiments of FIGS.", "2 and/or 3 to provide a cover providing both translucent regions with lighting provided by the cover and active illumination elements made up of LEDs and/or EL panels as will be discussed in relation to FIG.", "5.FIG.", "5 shows accessory device 500 having a combination of different types of lighting elements.", "In this particular embodiment instead of EL panel blocks as were depicted in FIG.", "2A and 2B specific phrases can be spelled out.", "For example lighting element 502 can be illuminated when an email is received.", "Lighting element 504 can be illuminated when an application related event has been detected and lighting element 506 can be illuminated when a calendar notification is received.", "The letters can be formed by shaping the EL panels to conform with a geometric pattern forming the letters or in some embodiments a masking pattern can be placed over larger EL panels to form corresponding letters.", "While only 3 words formed from EL panels are depicted it should be noted that any number of words can be disposed on the accessory device to provide a wide variety of detailed information to a user.", "Also depicted is segment 508 with a transparent window 510.Transparent window 510 can take on many different embodiments.", "For example, transparent window 510 can have the same thickness as the rest of accessory segment 508 allowing a user to clearly see through that specific portion of the accessory device while still providing a consistent surface of accessory device 500.In this depiction calendar icon 512 is displayed along an upper portion of transparent window 510 signifying that the displayed information relates to the calendar application.", "In other embodiments different icons such as an email icon or phone icon can be displayed signifying that the displayed information relates directly to an application associated with that particular icon.", "Display items 514 can include information about specific alerts.", "For example, each of display items 514 can include information about a calendar event.", "In still other embodiments a number of different icons 512 can be displayed concurrently with a numeric indicator associated with each displayed icon informing a user of a number of events or notifications that are pending for each displayed icon.", "In other embodiments the nature of transparent window 510 can be different.", "In one particular embodiment transparent window 510 can be a thin protective sheet.", "In this embodiment a user can interact with touch sensors disposed on an underlying tablet display screen, thereby allowing a certain number of inputs to be received by the tablet through the accessory device.", "Also pictured proximate transparent window 510 are illumination elements 516.In one embodiment illumination elements 516 can be RGB LEDs allowing multiple colors to be displayed by each of illumination elements 516.In the depicted embodiment illumination elements 516 can be useful for drawing a user's attention to transparent window 510 when information is being displayed through it.", "In this way a user is more likely to be alerted to the displayed notification.", "The color of illuminated illumination elements 516 can also be indicative of an urgency of the displayed message.", "In this way a user can ignore notifications of lower priority when that user is busy working on a higher priority task.", "Segment 518 has yet another means of visually informing a user of an event or change in operating state of an associated tablet device.", "In the depicted embodiment a number of illumination element groups 520 are disposed on segment 518.Each of illumination element groups 520 are configured to display a character.", "In the depicted embodiment the word “ALERT” is spelled out.", "It should be noted that additional illumination element groups 520 can be added to provide room for additional characters.", "Furthermore, a character animation can be displayed where a message is displayed by a scrolling animation revealing one character or in some embodiments one word at a time.", "In this way a large volume of information can be communicated to a user without the need to remove accessory device 500 from the associated tablet device.", "FIG.", "6 shows a narrower accessory device 600 including three segments 602-606.Similarly to FIG.", "5 this embodiment includes EL panels, a transparent window, and LEDs for providing visual lighting cues to a user of the accessory device.", "Although this has only three panels as opposed to the four shown in FIG.", "5 it should evident that a number of illumination means are still possible.", "A narrow accessory device as shown can be configured to match an electronic device with a narrower display screen.", "In this depiction accessory device 600 has transparent window 608 within segment 606.Such an embodiment is possible when an underlying display of an electronic device extends substantially towards an edge portion of the electronic device thereby allowing transparent window 608 to have a portion of display screen visible under all portions of it.", "It should be noted that in some embodiments transparent window can instead by partially opaque, only allowing a limited amount of light to penetrate the window.", "In this type of embodiment the display of the electronic device can be used to light up shapes or patterns instead of providing detailed information as the partially opaque nature of the display might not allow a user to easily read underlying text.", "Other lighting elements displayed in FIG.", "6 operate much the same as described in conjunction with FIG.", "5.FIG.", "7 shows a block diagram describing a process 700 for alerting a user of changes in an operating state of a host device coupled to an accessory device.", "In step 702 a control signal is received from the host device.", "The control signal can be received from any of a number of different types of host devices including for example a tablet device.", "In one embodiment the control signal can be transmitted via a physical connection between the accessory device and the host device, while in another embodiment the control signal can be delivered wirelessly over a wireless protocol such as Bluetooth or Wi-Fi.", "At step 704 power is received by the accessory device.", "Power can be received through a physical connector electrically coupling the accessory device to the host device.", "In other embodiments power can be inductively transferred from the host device to the accessory device by way of inductive coils arranged in both the accessory device and the host device, where the inductive coils are aligned when the accessory device covers a display of the host device.", "At step 706 the received power and control signal are used to illuminate a select number of illumination elements of the accessory device.", "The elements are illuminated in accordance with the control signal which can direct coordination of any number of the illumination elements to produce an illumination state.", "The illumination state produced is linked directly to an operating state of the host device.", "It should be noted that the term operating state is broadly defined and can include states such as low battery charge level, low/no connectivity, high priority message receipt (such as receipt of a message from a predefined list of individuals), application waiting on user input, or any number of other states a user should be aware of.", "In many embodiments illumination states can be user configurable.", "In one embodiment user configuration of illumination states can be performed on the host device through a graphical user interface disposed on the display of the host device.", "In some embodiments the accessory can have an associated application for customization of all illumination states, while in other embodiments user customization of illumination states can be an option available only when the accessory device is attached to the host device.", "For example, in a low power operating state all illumination states can be configured to operate at a reduced brightness to help conserve power.", "Customization of this operating state can include changing the definition of what percentage of a battery charge constitutes a low power state.", "A user can further customize an illumination state by defining exactly how much brightness is reduced in any given low power state.", "In some embodiments the cover illumination system can be configured to be completely disabled when the battery falls below a pre-defined threshold for power conservation purposes.", "The various aspects, embodiments, implementations or features of the described embodiments can be used separately or in any combination.", "Various aspects of the described embodiments can be implemented by software, hardware or a combination of hardware and software.", "The described embodiments can also be embodied as computer readable code on a computer readable medium for controlling manufacturing operations or as computer readable code on a computer readable medium for controlling a manufacturing line.", "The computer readable medium is any data storage device that can store data, which can thereafter be read by a computer system.", "Examples of the computer readable medium include read-only memory, random-access memory, CD-ROMs, HDDs, DVDs, magnetic tape, and optical data storage devices.", "The computer readable medium can also be distributed over network-coupled computer systems so that the computer readable code is stored and executed in a distributed fashion.", "The foregoing description, for purposes of explanation, used specific nomenclature to provide a thorough understanding of the described embodiments.", "However, it will be apparent to one skilled in the art that the specific details are not required in order to practice the described embodiments.", "Thus, the foregoing descriptions of specific embodiments are presented for purposes of illustration and description.", "They are not intended to be exhaustive or to limit the described embodiments to the precise forms disclosed.", "It will be apparent to one of ordinary skill in the art that many modifications and variations are possible in view of the above teachings." ] ]
Patent_15874232
[ [ "NON-AQUEOUS ELECTROLYTE AND LITHIUM ION BATTERY", "Provided are a non-aqueous electrolyte and a lithium ion battery containing the same.", "The non-aqueous electrolyte includes a lithium salt, a non-aqueous solvent and a first additive, the first additive includes phosphorothionates having a structure shown as formula (1): each R1 and R2 are selected from a group consisting of —(CH2)n-CH3, —(CH2)n-CF3, —NO2 and —SO3, n is an integer of 0 to 4; each R3 to R7 are selected from a group consisting of —CN, —F, —Cl, —Br, —CF3, —NO2 and —H; and at least one of R3 to R7 is selected from —CN, —F, —Cl, —Br, —CF3 and —NO2." ], [ "1.A non-aqueous electrolyte, comprising a lithium salt, a non-aqueous solvent and a first additive, wherein the first additive includes phosphorothionates having a structure shown as formula (1): wherein each R1 and R2 are selected from a group consisting of —(CH2)n-CH3, —(CH2)n-CF3, —NO2 and —SO3, n is an integer of 0 to 4; each R3 to R7 are selected from a group consisting of —CN, —F, —Cl, —Br, —CF3, —NO2 and —H; and at least one of R3 to R7 is selected from —CN, —F, —Cl, —Br, —CF3 and —NO2.2.The non-aqueous electrolyte according to claim 1, wherein R5 is —CN or —NO2, and R3, R4, R6 and R7 are —H.", "3.The non-aqueous electrolyte according to claim 1, wherein both R1 and R2 are methyl or both R1 and R2 are ethyl.", "4.The non-aqueous electrolyte according to claim 1, wherein both R1 and R2 are methyl, R5 is —CN, and R3, R4, R6 and R7 are —H.", "5.The non-aqueous electrolyte according to claim 1, wherein the first additive is of a content of about 0.1% to about 10% based on a total mass of the non-aqueous electrolyte.", "6.The non-aqueous electrolyte according to claim 1, wherein the first additive is of a content of about 0.5% to about 1.5% based on a total mass of the non-aqueous electrolyte.", "7.The non-aqueous electrolyte according to claim 1, further comprising a second additive including LiBOB or vinylene carbonate.", "8.The non-aqueous electrolyte according to claim 7, wherein a mass ratio of the first additive to the second additive is 1:3 to 3:1.9.A lithium ion battery, comprising: a housing, a core accommodated in the housing, wherein the core include an anode comprising an anode active substance, a cathode comprising a cathode active substance, and a separator disposed between the anode and the cathode, and a non-aqueous electrolyte accommodated in the housing, wherein the non-aqueous electrolyte comprises a lithium salt, a non-aqueous solvent and a first additive, wherein the first additive includes phosphorothionates having a structure shown as formula (1): wherein each R1 and R2 are selected from a group consisting of —(CH2)n-CH3, —(CH2)n-CF3, —NO2 and —SO3, n is an integer of 0 to 4; each R3 to R7 are selected from a group consisting of —CN, —F, —Cl, —Br, —CF3, —NO2 and —H; and at least one of R3 to R7 is selected from —CN, —F, —Cl, —Br, —CF3 and —NO2.10.The lithium ion battery according to claim 9, wherein the anode active substance is at least one selected from a group consisting of LiNi0.5Mn1.5O4, LiNi1-xMnxO2, LiNi1-xCoxO2, LiNi1-y-zCoyMnzO2 and LiNi1-y-zCoyAlzO2, wherein 0≤x≤1, y≥0, z≥0, and y+z≤1; and the cathode active substance includes lithium metal.", "11.The lithium ion battery according to claim 9, wherein R5 is —CN or —NO2, and R3, R4, R6 and R7 are —H.", "12.The lithium ion battery according to claim 9, wherein both R1 and R2 are methyl or both R1 and R2 are ethyl.", "13.The lithium ion battery according to claim 9, wherein both R1 and R2 are methyl, R5 is —CN, and R3, R4, R6 and R7 are —H.", "14.The lithium ion battery according to claim 9, wherein the first additive is of a content of about 0.1% to about 10% based on a total mass of the non-aqueous electrolyte.", "15.The lithium ion battery according to claim 9, wherein the first additive is of a content of about 0.5% to about 1.5% based on a total mass of the non-aqueous electrolyte.", "16.The lithium ion battery according to claim 9, further comprising a second additive including LiBOB or vinylene carbonate.", "17.The lithium ion battery according to claim 16, wherein a mass ratio of the first additive to the second additive is 1:3 to 3:1.18.A method for preparing a non-aqueous electrolyte, comprising: dissolving a lithium salt in a non-aqueous solvent inside an argon glove box to obtain a mixture; and adding a first additive to the obtained mixture, wherein the first additive includes phosphorothionates having a structure shown as formula (1): wherein each R1 and R2 are selected from a group consisting of —(CH2)n-CH3, —(CH2)n-CF3, —NO2 and —SO3, n is an integer of 0 to 4; each R3 to R7 are selected from a group consisting of —CN, —F, —Cl, —Br, —CF3, —NO2 and —H; and at least one of R3 to R7 is selected from —CN, —F, —Cl, —Br, —CF3 and —NO2.19.The method according to claim 18, prior to adding the first additive, further comprising: mixing the first additive and a second additive to create a second mixture; and adding the second mixture to the obtained mixture, wherein the second additive includes LiBOB or vinylene carbonate, and a mass ratio of the first additive to the second additive is 1:3 to 3:1.20.The method according to claim 18, wherein both R1 and R2 are methyl or both R1 and R2 are ethyl, R5 is —CN or —NO2, and R3, R4, R6 and R7 are —H." ], [ "<SOH> BACKGROUND <EOH>Recently, secondary lithium ion batteries with high energy density have become focus of people's attention.", "Consequently, people also find some new active materials available for the secondary lithium ion batteries.", "For instance, a high-voltage anode material LiNi 0.5 Mn 1.5 O 4 of which a voltage-platform is about 4.7V was once disclosed in the prior art, the increase of a working voltage thereof directly improves the service power of a battery, and the material is of great practical significance.", "However, at the present stage, most of lithium battery electrolyte systems may be steadily used only under the voltage of 4.5V or less.", "When the working voltage exceeds 4.5V, the electrolyte systems may be oxidatively decomposed, and as a result, the battery couldn't work normally.", "Therefore, existing electrolytes seriously hinder wide application of high-voltage anode materials." ], [ "<SOH> SUMMARY <EOH>In view of the above technical problems, the present disclosure provides in embodiments a novel non-aqueous electrolyte.", "The novel non-aqueous electrolyte includes phosphorothionates having a unique structure in the present disclosure.", "Electrons in a molecule of the unique-structured phosphorothionates can be automatically gathered to a certain end of the molecule, such that the whole molecule is negatively charged.", "When two ends of a battery generate voltages, the molecule will be instantaneously adsorbed to the surface of an anode, and therefore the anode is protected from contacting the electrolyte, thereby isolating a reaction therebetween, and stopping degradation of the electrolyte on the surface of the anode.", "Specifically, the present disclosure provides a non-aqueous electrolyte, including a lithium salt, a non-aqueous solvent and a first additive including phosphorothionates having a structure shown as formula (1): each R 1 and R 2 are selected from a group consisting of —(CH 2 )n-CH 3 , —(CH 2 )n-CF 3 , —NO 2 and —SO 3 ; n is an integer of 0 to 4; each R 3 to R 7 are selected from a group consisting of —CN, —F, —Cl, —Br, —CF 3 , —NO 2 and —H; and at least one of R 3 to R 7 is selected from —CN, —F, —Cl, —Br, —CF 3 and —NO 2 .", "In the present disclosure, the first additive of the present disclosure is added into a non-aqueous electrolyte.", "The first additive includes an organic phosphorothionate molecule having a structure shown as formula (1).", "One end of the molecule is a benzene ring with a strongly polar group, a strong electron withdrawing effect is provided, and therefore the whole molecule will be negatively charged.", "After a voltage is generated between an anode and cathode of a battery, the first additive will be instantaneously adsorbed to the surface of the anode, and the adsorption capacity will be increased along with the increase of the anode voltage.", "After the first additive is adsorbed on the surface of the anode, a contact between the anode and the electrolyte can be cut off, and a reaction therebetween is stopped, thereby preventing degradation of the electrolyte on the surface of the anode, and achieving a function of protecting film forming of the anode.", "The present disclosure further provides in embodiments a lithium ion battery, which includes a housing, a core accommodated in the housing and having an anode, a cathode and a separator disposed between the anode and the cathode, and a non-aqueous electrolyte above-mentioned which is also accommodated in the housing, the anode includes an anode active substance, the cathode includes a cathode active substance.", "The present disclosure can effectively improve, by adding the first additive of the present disclosure such as the phosphorothionates having a structure shown as formula (1) into the non-aqueous electrolyte, the electric potential of oxidative decomposition of the non-aqueous electrolyte.", "The non-aqueous electrolyte of the present disclosure is configured to prepare a lithium ion battery, and the obtained battery not only has higher charge-discharge performance, but also is high in capacity retention ratio after cycle, low in deformation before and after cycle, and long in service life.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATION The application is a continuation application of International Application No.", "PCT/CN2016/097393, filed on Aug. 30, 2016, which is based on and claims priority to and benefits of Chinese Patent Applications No.", "201510548371.8, filed with the State Intellectual Property Office of P. R. China on Aug. 31, 2015.The entire content of the above-identified applications are incorporated herein by reference.", "TECHNICAL FIELD The present disclosure relates to the field of lithium ion batteries, and in particular to a non-aqueous electrolyte and a lithium ion battery containing the same.", "BACKGROUND Recently, secondary lithium ion batteries with high energy density have become focus of people's attention.", "Consequently, people also find some new active materials available for the secondary lithium ion batteries.", "For instance, a high-voltage anode material LiNi0.5Mn1.5O4 of which a voltage-platform is about 4.7V was once disclosed in the prior art, the increase of a working voltage thereof directly improves the service power of a battery, and the material is of great practical significance.", "However, at the present stage, most of lithium battery electrolyte systems may be steadily used only under the voltage of 4.5V or less.", "When the working voltage exceeds 4.5V, the electrolyte systems may be oxidatively decomposed, and as a result, the battery couldn't work normally.", "Therefore, existing electrolytes seriously hinder wide application of high-voltage anode materials.", "SUMMARY In view of the above technical problems, the present disclosure provides in embodiments a novel non-aqueous electrolyte.", "The novel non-aqueous electrolyte includes phosphorothionates having a unique structure in the present disclosure.", "Electrons in a molecule of the unique-structured phosphorothionates can be automatically gathered to a certain end of the molecule, such that the whole molecule is negatively charged.", "When two ends of a battery generate voltages, the molecule will be instantaneously adsorbed to the surface of an anode, and therefore the anode is protected from contacting the electrolyte, thereby isolating a reaction therebetween, and stopping degradation of the electrolyte on the surface of the anode.", "Specifically, the present disclosure provides a non-aqueous electrolyte, including a lithium salt, a non-aqueous solvent and a first additive including phosphorothionates having a structure shown as formula (1): each R1 and R2 are selected from a group consisting of —(CH2)n-CH3, —(CH2)n-CF3, —NO2 and —SO3; n is an integer of 0 to 4; each R3 to R7 are selected from a group consisting of —CN, —F, —Cl, —Br, —CF3, —NO2 and —H; and at least one of R3 to R7 is selected from —CN, —F, —Cl, —Br, —CF3 and —NO2.In the present disclosure, the first additive of the present disclosure is added into a non-aqueous electrolyte.", "The first additive includes an organic phosphorothionate molecule having a structure shown as formula (1).", "One end of the molecule is a benzene ring with a strongly polar group, a strong electron withdrawing effect is provided, and therefore the whole molecule will be negatively charged.", "After a voltage is generated between an anode and cathode of a battery, the first additive will be instantaneously adsorbed to the surface of the anode, and the adsorption capacity will be increased along with the increase of the anode voltage.", "After the first additive is adsorbed on the surface of the anode, a contact between the anode and the electrolyte can be cut off, and a reaction therebetween is stopped, thereby preventing degradation of the electrolyte on the surface of the anode, and achieving a function of protecting film forming of the anode.", "The present disclosure further provides in embodiments a lithium ion battery, which includes a housing, a core accommodated in the housing and having an anode, a cathode and a separator disposed between the anode and the cathode, and a non-aqueous electrolyte above-mentioned which is also accommodated in the housing, the anode includes an anode active substance, the cathode includes a cathode active substance.", "The present disclosure can effectively improve, by adding the first additive of the present disclosure such as the phosphorothionates having a structure shown as formula (1) into the non-aqueous electrolyte, the electric potential of oxidative decomposition of the non-aqueous electrolyte.", "The non-aqueous electrolyte of the present disclosure is configured to prepare a lithium ion battery, and the obtained battery not only has higher charge-discharge performance, but also is high in capacity retention ratio after cycle, low in deformation before and after cycle, and long in service life.", "DETAILED DESCRIPTION Hereinafter, specific embodiments of the present disclosure will be described in detail.", "It is to be understood that the specific embodiments described herein are provided merely for the purpose of illustration and explanation and not intended to limit the scope of the present disclosure.", "The present disclosure provides a non-aqueous electrolyte, including a lithium salt, a non-aqueous solvent and a first additive.", "The first additive includes phosphorothionates having a structure shown as formula (1): each R1 and R2 are selected from a group consisting of —(CH2)n-CH3, —(CH2)n-CF3, —NO2 and —SO3; n is an integer of 0 to 4; each R3 to R7 are selected from a group consisting of —CN, —F, —Cl, —Br, —CF3, —NO2 and —H; and at least one of R3 to R7 is selected from —CN, —F, —Cl, —Br, —CF3 and —NO2.We found that the addition of the phosphorothionates having the structure shown as formula (1) of the present disclosure in the non-aqueous electrolyte can greatly improve the electric potential of oxidative decomposition of the non-aqueous electrolyte.", "The phosphorothionates having the structure shown as formula (1) of the present disclosure can be adsorbed to an anode of a battery in situ.", "When the voltage of the battery is higher, the phosphorothionates can be more firmly adsorbed; and when the voltage drops, desorption occurs.", "This kind of characteristic not only can form a protective film on the anode of the battery to prevent the electrolyte from being oxidized on the surface of the anode of the battery, but also does not have any impact on the performance of the electrolyte.", "In some embodiments, R5 is —CN or —NO3, and R3, R4, R6 and R7 are hydrogen atoms.", "In some embodiments, both R1 and R2 are methyl or both R1 and R2 are ethyl.", "In some embodiments, both R1 and R2 are methyl, R5 is —CN, and R3, R4, R6 and R7 are —H; and in this case, the phosphorothionates having the structure shown as formula (1) of the present disclosure is O-4-cyanophenyl O,O-dimethyl phosphorothionate.", "In some embodiments, in the non-aqueous electrolyte, the first additive is of a content of about 0.1% to 10%, based on the total weight of the non-aqueous electrolyte.", "In some other embodiments, the first additive is of a content of about 0.5% to 1.5%.", "When the content of the first additive is over-high, the charge-discharge capacity of the battery will be affected, and when the content of the first additive is over-low, the electric potential of oxidative decomposition of the non-aqueous electrolyte is not obviously improved.", "In some embodiments, the non-aqueous solvent may be selected from at least one of a carboxylic ester solvent, a carbonic ester solvent, a nitrile solvent or a ketone solvent.", "In some embodiments, the non-aqueous solvent is selected from one or more of ethyl methyl carbonate (EMC), dimethyl carbonate (DMC), diethyl carbonate (DEC), ethylene carbonate (EC), propylene carbonate (PC), butylene carbonate (BC), ethylene sulfite (ES), propylene sulfite (PS), diethyl sulfite (DES), γ-butyrolactone (BL), dimethyl sulfoxide (DMSO), ethyl acetate and methyl acetate.", "In some embodiments, the non-aqueous solvent is selected from one or more of carbonates such as EMC, DMC and DEC.", "In some specific embodiments, the non-aqueous solvent is a mixture of EMC, DMC and DEC, and a mass ratio of EMC to DMC to DEC is about 2:1:3 to 2:3:1.When the content ratio of the first additive to the non-aqueous solvent falls within the above range, the prepared lithium ion battery may have a higher charge-discharge capacity, better cycle performance and longer service life.", "In some embodiments, the lithium salt can be selected from one or more of LiPF6, LiClO4, LiBF4, LiAsF6, LiClO4, LiSiF6, LiAlCl4, LiBOB, LiODFB, LiCl, LiBr, LiI, LiCF3SO3, Li(CF3CO2)2N, Li(CF3SO2)2N or Li(SO2C2F5)2N.", "In some embodiments, the lithium salt is of a weight of about 8.5 wt % to 18.5 wt % of the total weight of the electrolyte.", "In some embodiments, the present disclosure adopts LiPF6 as the lithium salt, the concentration thereof is about 8.5 wt % to 18.5 wt %, and optimally about 10 wt % to 16 wt %.", "In some embodiments, the non-aqueous electrolyte further includes a second additive, and the second additive includes LiBOB or vinylene carbonate.", "Because vinylene carbonate or LiBOB has excellent cathode film forming performance, an excellent SEI film can be formed on the surface of a cathode by using the vinylene carbonate or LiBOB as the second additive, and the cathode is protected from being eroded by the electrolyte.", "The phosphorothionates having a structure shown as formula (1) in the present application, serving as the first additive, is added into the non-aqueous electrolyte to be mainly capable of forming a protective film on the surface of an anode material so as to isolate a side reaction between the anode material and the electrolyte.", "Thus, the cooperative usage of the first additive and the second additive can protect the anode and cathode of the battery simultaneously.", "By applying the non-aqueous electrolyte, to which the first additive and the second additive are added, to a battery, the prepared battery may have high energy density and high charge-discharge capacity.", "Particularly, cooperative application of the non-aqueous electrolyte and a high-voltage electrode material to a high-voltage system may achieve an extremely obvious effect.", "In some embodiments, a mass ratio of the first additive to the second additive is about 1:3 to 3:1.The inventor of the present application found that the prepared battery has, when the mass ratio of the first additive to the second additive is controlled within the above range, optimal cycle performance and charge-discharge performance.", "In some embodiments, all the components including the lithium salt, the non-aqueous solvent and various additives are mixed in argon gloves.", "An exemplary method of the present disclosure includes: dissolving the lithium salt in the non-aqueous solvent inside an argon glove box; and then adding the first additive of the present disclosure or a mixture of the first additive and the second additive so as to obtain a non-aqueous electrolyte.", "The present disclosure also provides a lithium ion battery, which includes a housing, a core accommodated in the housing and having an anode, a cathode and a separator disposed between the anode and the cathode, and a non-aqueous electrolyte mentioned above.", "The anode includes an anode collector and an anode material disposed on the surface of the anode collector.", "The anode material includes an anode active substance, an anode conductive agent and an anode binder.", "The anode active substance, the anode conductive agent and the anode binder may be an anode active substance, an anode conductive agent and an anode binder.", "In some embodiments, the anode active substance is one or more of LiNi0.5Mn1.5O4, LiNi1-xMnxO2, LiNi1-xCoxO2, LiNi1-y-zCoyMnzO2 and LiNi1-y-zCoyAlzO2, where 0≤x≤1, y≥0, z≥0, and y+z≤1.The anode conductive agent is one or more of acetylene black and a carbon nano tube.", "The anode binder is polyvinylidene fluoride.", "The cathode includes a cathode collector and a cathode material disposed on the surface of the cathode collector.", "The cathode material includes a cathode active substance and a cathode binder.", "The cathode material may also selectively include a cathode conductive agent.", "The cathode conductive agent may be identical to or different from the anode conductive agent.", "The cathode active substance and the cathode binder may be a cathode active substance and a cathode binder.", "For instance, the cathode active substance may be a lithium metal, a lithium-aluminum alloy, graphite, modified graphite, hard carbon, modified hard carbon or the like.", "In some embodiments, the cathode active substance is a lithium metal sheet.", "The present disclosure only relates to improvement on an electrolyte of an existing lithium ion battery, and does not specially limit other components and structure of the lithium ion battery.", "A preparation method for a lithium ion battery of the present disclosure includes: providing a separator between a prepared anode and cathode; winding or folding the separator, anode and cathode to form a core; accommodating the core in a battery housing; injecting an electrolyte; and then sealing the battery housing to prepare a lithium ion battery.", "The non-aqueous electrolyte provided by the present disclosure has better high-voltage resistance and higher electric potential of oxidative decomposition.", "Meanwhile, a battery prepared from the non-aqueous electrolyte has a better cycle performance and charge-discharge performance.", "The lithium ion battery provided by the present disclosure has a higher energy density and first charge-discharge performance, and has an excellent storage performance and cycle performance at high temperatures.", "The non-aqueous electrolyte and the lithium ion battery containing the same of the present disclosure will be further illustrated below in conjunction with embodiments.", "Embodiment 1 (1) Preparation of Non-Aqueous Electrolyte: 100 parts by weight of non-aqueous solvents from EC, DEC and DMC in a ratio of 2:1:3 in an argon glove box were prepared, 12 parts by weight of LiPF6 were dissolved into the prepared non-aqueous solvents, and then 1 part by weight of O-4-cyanophenyl O,O-dimethyl phosphorothionates (phosphorothionates having structure shown as formula (1) of the present disclosure was added, both R1 and R2 are —CH3, R5 is —CN, and R3, R4, R6 and R7 are hydrogen atoms), thereby obtaining a non-aqueous electrolyte of the present embodiment, which was recorded as C1; and (2) Preparation of Lithium Ion Battery: An anode active substance (LiNi0.5Mn1.5O4), acetylene black and polyvinylidene fluoride in a ratio of 90:5:5 were uniformly mixed to obtain a mixture, and then the mixture was pressed onto an aluminum foil to obtain an anode sheet; a lithium metal sheet was provided as a cathode sheet; and a PE/PP composite separator was provided as an ion exchange membrane, and a button battery S1 was made from the non-aqueous electrolyte C1 of the present embodiment Embodiment 2 A non-aqueous electrolyte and a button battery were prepared using the steps identical to those in embodiment 1, except that: O-4-cyanophenyl O,O-dimethyl phosphorothionate was replaced with 1 part by weight of O-(2,6-dichloro-4-tolyl)O,O-dimethyl phosphorothionates (phosphorothionates having a structure shown as formula (1) of the present disclosure, all of R1, R2 and R5 are —CH3, both R3 and R7 are —Cl, and both R4 and R6 are —H) in step (1), thereby preparing a non-aqueous electrolyte C2 and a button battery S2.Embodiment 3 A non-aqueous electrolyte and a button battery were prepared using the steps identical to those in embodiment 1, except that: 1 part by weight of vitamin C was further added in step (1), thereby preparing a non-aqueous electrolyte C3 and a button battery S3.Embodiment 4 A non-aqueous electrolyte and a button battery were prepared using the steps identical to those in embodiment 1, except for that: 0.5 parts by weight of vitamin C and 0.5 parts by weight of LiBOB were further added in Step (1), thereby preparing a non-aqueous electrolyte C4 and a button battery S4.Embodiment 5 A non-aqueous electrolyte and a button battery were prepared using the steps identical to those in embodiment 1, except that: 0.5 parts by weight of LiBOB were further added in step (1), thereby preparing a non-aqueous electrolyte C5 and a button battery S5.Embodiment 6 A non-aqueous electrolyte and a button battery were prepared using the steps identical to those in embodiment 1, except for that: in step (2), the anode active substance was replaced with LiNi0.5Mn0.5O2, and the cathode active substance was replaced with a lithium metal sheet, thereby preparing a non-aqueous electrolyte C6 and a button battery S6.Embodiment 7 A non-aqueous electrolyte and a button battery were prepared using the steps identical to those in embodiment 1.Differently, in Step (2), an anode active substance was replaced with LiNi0.5Mn0.5O2, and a cathode active substance was replaced with graphite, thereby preparing a non-aqueous electrolyte C7 and a button battery S7.Comparison Example 1 A non-aqueous electrolyte and a button battery were prepared using the steps identical to those in embodiment 1, except that: in step (1), O-4-cyanophenyl O,O-dimethyl phosphorothionate was replaced with 0.5 parts by weight of p-tolunitrile, thereby preparing a non-aqueous electrolyte DC1 and a button battery DS1.Comparison Example 2 A non-aqueous electrolyte and a button battery were prepared using the steps identical to those in embodiment 1, except that: in step (1), O-4-cyanophenyl O,O-dimethyl phosphorothionate was replaced with 0.8 parts by weight of diethyl(cyanomethyl)phosphonate, thereby preparing a non-aqueous electrolyte DC2 and a button battery DS2.Comparison Example 3 A non-aqueous electrolyte and a button battery were prepared using the steps identical to those in embodiment 1, except that: in step (1), 12 parts by weight of O-4-cyanophenyl O, O-dimethyl phosphorothionate were added, thereby preparing a non-aqueous electrolyte DC3 and a button battery DS3.Comparison Example 4 A non-aqueous electrolyte and a button battery were prepared using the steps identical to those in embodiment 1, except that: in step (1), 0.08 parts by weight of O-4-cyanophenyl O, O-dimethyl phosphorothionate were added, thereby preparing a non-aqueous electrolyte DC4 and a button battery DS4.Performance Test (1) Test on Electric Potential of Oxidative Decomposition of Electrolyte Under High Voltage: The non-aqueous electrolytes C1 to C7 prepared in the embodiments 1 to 7 and the non-aqueous electrolytes DC1 to DC4 prepared in the comparison examples 1 to 4 were placed into a container, using a platinum sheet as a working electrode, lithium sheets as a counter electrode and a reference electrode, tests were performed by using an electrochemical workstation, a linear sweep voltammetry (LSV) program was adopted for performing sweep, an open circuit voltage (OCV) was tested under a sweep interval of 3 to 7V, and a sweep rate of 2 mV, a test result is shown in Table 1.TABLE 1 Electrolyte Oxidative decomposition/V C1 5.8 C2 5.6 C3 5.3 C4 5.2 C5 5.3 C6 5.8 C7 5.7 DC1 4.7 DC2 4.6 DC3 6.0 DC4 4.9 (2) Test on Specific Capacity of Battery Under High Voltage: All experimental batteries S1 to S7 and DS1 to DS4 were charged under a constant current of 0.1 C at a normal temperature until a cutoff voltage reached 4.9V, these batteries were discharged under the same current until the cutoff voltage reached 3.0V, and a charge-discharge capacity was recorded, a result was shown in Table 2.", "(3) Test on Battery Cycle: These batteries S1 to S7 and DS1 to DS4 were installed on a secondary battery performance tester BS-9300.These batteries were charged under a constant current of 1 C and a constant voltage until the cutoff voltage reaches 4.9V, and then was rested for 5 minutes.", "Next, these batteries were discharged under a current of 1 C until the cutoff voltage reached 3.0V, and then were charged under a constant current of 1 C and a constant voltage until the cutoff voltage reached 4.9V.", "These charge and discharge steps were repeated for 100 times.", "After the cycle was finished, the temperature of these batteries returned to the room temperature, then these batteries were fully charged under a current of 1 C, and then discharged under a current of 0.2 C until the cutoff voltage reached 3.0V, thereby obtaining a residual capacity.", "A capacity retention rate was obtained by dividing the residual capacity by a first cycle capacity, and a result was shown in Table 2.TABLE 2 Capacity First First charge- retention rate Battery First charge discharge discharge after cycle for number capacity/mAh capacity/mAh efficiency/% 100 times/% S1 133 148 89.8 85 S2 125 150 83.2 78 S3 126 147 85.7 75 S4 115 148 77.7 70 S5 120 140 85.7 80 S6 124 144 86.1 75 S7 124 146 84.9 70 DS1 70 110 63.6 30 DS2 75 109 68.8 32 DS3 90 140 64.3 30 DS4 85 175 48.6 25 From Table 1 and Table 2, it can be seen that the minimum electric potential of oxidative decomposition of the non-aqueous electrolyte provided by the present disclosure is 5.2V, while the electric potential of oxidative decomposition of the non-aqueous electrolytes, to which p-tolunitrile and diethyl(cyanomethyl)phosphonate are added, in comparison example 1 and comparison example 2 are only 4.6V and 4.7V, and the content of the phosphorothionates having a structure shown as Formula (1) of the present disclosure, added similarly to the comparison example 3 and the comparison example 4, is higher or lower than the content range of the present application.", "Although the electric potential of oxidative decomposition of the non-aqueous electrolyte can be still improved, we found that when the non-aqueous electrolyte is applied to a battery, the cycle performance and charge-discharge performance of the battery are affected.", "Meanwhile, from Table 2, it can also be seen that the maximum capacity retention rate of a battery sample with the electrolyte provided according to the present disclosure after repeating for 100 times is 85%, the minimum capacity retention rate is 70%, and the maximum capacity retention rate of battery samples prepared in the comparison examples after repeating for 100 times is only 32%.", "Thus, it can be seen that the electrolyte provided by the present disclosure has a good high-voltage resistance, and the cycle performance of the battery with the electrolyte provided by the present disclosure is effectively improved.", "While the present disclosure has been described in detail with reference to preferred embodiments hereinbefore, the present disclosure is not limited to particular details in the above-described embodiments.", "Various modifications made to the technical solution of the present disclosure without departing from the scope of the present disclosure fall within the protection scope of the present disclosure.", "It is to be noted that the specific technical features described in the above detailed embodiments may be combined in any suitable manner without contradiction.", "To avoid unnecessary repetition, the various possible combinations are not further described in the present disclosure again.", "In addition, various embodiments of the present disclosure may be combined in any way without departing from the spirit of the present disclosure, and such combinations are also embraced in the protection scope of the present disclosure." ] ]
Patent_15874234
[ [ "DEXTEROUS SURGICAL MANIPULATOR AND METHOD OF USE", "A surgical manipulator includes an internal working end having an internal joint, and an external control interface linked to the internal working end for controlling the internal working end.", "The external control interface includes at least one lever defining a grip volume for a surgeon's hand when gripping and operating the at least one lever, and an external joint linked to the internal joint for controlling the internal joint.", "The external joint is positioned substantially within the grip volume." ], [ "1.A surgical manipulator, comprising: an internal working end having an internal joint; and an external control interface linked to the internal working end for controlling the internal working end, the external control interface including: a first lever and a second lever that together define a grip volume for a surgeon's hand when gripping and operating the first lever and the second lever, wherein at least one of the first lever and the second lever is pivotable about a first pivot axis (J), and an external wrist joint linked to the internal joint for controlling the internal joint; wherein the external wrist joint is positioned at least substantially within the grip volume, wherein the external wrist joint includes a second pivot axis (H) and a third pivot axis (G) that are offset from one another, the second pivot axis (H) being disposed between the first pivot axis (J) and the third pivot axis (G); wherein the first lever, the second lever, and the first pivot axis (J) together are rotatable about the third pivot axis (G).", "2.The surgical manipulator of claim 1, wherein the grip volume is a spherical grip volume that is defined by distal end portions of both the first and second levers.", "3.The surgical manipulator of claim 1, wherein the first lever and the second lever are substantially the same shape and size and mirror one another across a centerline (F) that extends from the first pivot axis toward the internal working end.", "4.The surgical manipulator of claim 1, wherein the grip volume is substantially between the first pivot axis and the internal working end.", "5.The surgical manipulator of claim 1, further comprising a drive cable coupled between the internal working end and the control interface for mechanically linking the internal working end and the control interface.", "6.The surgical manipulator of claim 5, further comprising a cable box in which an end of the drive cable is secured, wherein the first lever is coupled to the cable box by a link.", "7.The surgical manipulator of claim 6, wherein the link includes a first end pivotably connected to the first lever and a second end pivotably connected to the cable box.", "8.The surgical manipulator of claim 5, wherein the external wrist joint includes a pulley about which the drive cable is disposed, the pulley defining the third pivot axis.", "9.The surgical manipulator of claim 1, further comprising: an internal elbow joint having one degree of freedom; and an external elbow joint having one degree of freedom; wherein the external elbow joint is mechanically coupled to the internal elbow joint for mechanically controlling the internal elbow joint.", "10.The surgical manipulator of claim 9, further comprising: a drive cable mechanically coupling the external wrist joint to the internal wrist joint for translation of movement therebetween; and a sleeve disposed about the drive cable and mechanically coupling the external elbow joint to the internal elbow joint for translation of movement therebetween.", "11.The surgical manipulator of claim 1, further comprising a support member to which both the first and second levers are coupled, wherein the first pivot axis extends through the support member.", "12.The surgical manipulator of claim 11, wherein the support member is pivotable about the third pivot axis (G)." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Dexterous surgical manipulators provide a small surgical “hand,” or gripper, which can access hard-to-reach places, such as a throat or a body cavity during laparoscopic surgery.", "The gripper is operable by a user interface, which translates motions performed by a surgeon on the user interface into motions performed by the gripper.", "User interfaces are typically non-intuitive and require practice and experience to use.", "Motions performed by the surgeon on the user interface may be reversed or mirrored when outputted by the gripper, and motions of the surgeon's hand may not correspond intuitively with motions of the gripper." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The surgical manipulator of the present invention provides seven degrees-of-freedom and uses an interface which maps motions of the surgeon's input to the tool's “hands.” This provides the surgeon with an intuitive interface without the need for computer intervention.", "In one aspect, the invention provides a surgical manipulator having an internal working end including an internal joint, and an external control interface linked to the internal working end for controlling the internal working end.", "The external control interface includes at least one lever defining a grip volume for a surgeon's hand when gripping and operating the at least one lever, and an external joint linked to the internal joint for controlling the internal joint.", "The external joint is positioned substantially within the grip volume.", "In another aspect, the invention provides a surgical manipulator having a first end, and a control interface for controlling the first end.", "The control interface includes at least one lever being pivotable about an axis and defining a grip.", "The grip is positioned between the first end and the axis.", "In yet another aspect, the invention provides a surgical manipulator having a first end for performing a dexterous operation, and a second end mechanically coupled to the first end for controlling operation of the first end.", "The first end is controlled manually by the second end.", "The first end includes a pair of gripper fingers each having a degree of freedom and an internal wrist joint having two degrees of freedom.", "The second end includes a pair of levers each having a degree of freedom for each controlling one of the pair of gripper fingers.", "The second end also includes an external wrist joint having two degrees of freedom for controlling the internal wrist joint.", "Movements of the second end are mechanically translated into movements of the first end.", "The surgical manipulator of the present invention may also include the following features: 1.The size of the “hand” can be as small as 4 mm in diameter.", "2.The hand can provide three degrees-of-freedom that can be controlled by a four tension wire interface.", "This includes both the way the hand is driven/achieves three degrees-of-freedom with only four control wires and the way the use inputs are mapped to the four control wires.", "3.The use of an intuitive interface between the operating controls and the seven degrees-of-freedom of the hand provides the surgeon with an easy to learn and use interface.", "4.The use of Nitnol tubes as sleeves for pull cables (similar to bicycle break cables) enables the use of very small pull cable arrangements.", "The surgical manipulator offers surgeons a dexterous hand which can be used in procedures that would normally require the use of rigid laparoscopic or laparoscopic-type tool.", "The surgical manipulator can be suitable for use in laryngoscopic surgery or other surgical procedures, such as NOTES based operations, vaginal operations, and as a reach extension tool for working with obese patients." ], [ "RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "13/460,497, filed Apr.", "30, 2012, and claims priority to U.S.", "Provisional Patent Application No.", "61/481,038, filed on Apr.", "29, 2011, the entire contents of each of which are incorporated herein by reference.", "FIELD OF THE INVENTION The present invention relates to a mechanical dexterous surgical manipulator for use as a tool in surgical procedures.", "BACKGROUND OF THE INVENTION Dexterous surgical manipulators provide a small surgical “hand,” or gripper, which can access hard-to-reach places, such as a throat or a body cavity during laparoscopic surgery.", "The gripper is operable by a user interface, which translates motions performed by a surgeon on the user interface into motions performed by the gripper.", "User interfaces are typically non-intuitive and require practice and experience to use.", "Motions performed by the surgeon on the user interface may be reversed or mirrored when outputted by the gripper, and motions of the surgeon's hand may not correspond intuitively with motions of the gripper.", "SUMMARY OF THE INVENTION The surgical manipulator of the present invention provides seven degrees-of-freedom and uses an interface which maps motions of the surgeon's input to the tool's “hands.” This provides the surgeon with an intuitive interface without the need for computer intervention.", "In one aspect, the invention provides a surgical manipulator having an internal working end including an internal joint, and an external control interface linked to the internal working end for controlling the internal working end.", "The external control interface includes at least one lever defining a grip volume for a surgeon's hand when gripping and operating the at least one lever, and an external joint linked to the internal joint for controlling the internal joint.", "The external joint is positioned substantially within the grip volume.", "In another aspect, the invention provides a surgical manipulator having a first end, and a control interface for controlling the first end.", "The control interface includes at least one lever being pivotable about an axis and defining a grip.", "The grip is positioned between the first end and the axis.", "In yet another aspect, the invention provides a surgical manipulator having a first end for performing a dexterous operation, and a second end mechanically coupled to the first end for controlling operation of the first end.", "The first end is controlled manually by the second end.", "The first end includes a pair of gripper fingers each having a degree of freedom and an internal wrist joint having two degrees of freedom.", "The second end includes a pair of levers each having a degree of freedom for each controlling one of the pair of gripper fingers.", "The second end also includes an external wrist joint having two degrees of freedom for controlling the internal wrist joint.", "Movements of the second end are mechanically translated into movements of the first end.", "The surgical manipulator of the present invention may also include the following features: 1.The size of the “hand” can be as small as 4 mm in diameter.", "2.The hand can provide three degrees-of-freedom that can be controlled by a four tension wire interface.", "This includes both the way the hand is driven/achieves three degrees-of-freedom with only four control wires and the way the use inputs are mapped to the four control wires.", "3.The use of an intuitive interface between the operating controls and the seven degrees-of-freedom of the hand provides the surgeon with an easy to learn and use interface.", "4.The use of Nitnol tubes as sleeves for pull cables (similar to bicycle break cables) enables the use of very small pull cable arrangements.", "The surgical manipulator offers surgeons a dexterous hand which can be used in procedures that would normally require the use of rigid laparoscopic or laparoscopic-type tool.", "The surgical manipulator can be suitable for use in laryngoscopic surgery or other surgical procedures, such as NOTES based operations, vaginal operations, and as a reach extension tool for working with obese patients.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a side view of a surgical manipulator in accordance with the invention.", "FIG.", "2 is a simplified view of the surgical manipulator of FIG.", "1.FIG.", "3 is an enlarged view of a working end of the surgical manipulator of FIG.", "1.FIG.", "4 is an enlarged view of a control interface of the surgical manipulator of FIG.", "1.FIG.", "5 is a side view of the working end of the surgical manipulator of FIG.", "1 in a straightened position and having cables.", "FIG.", "6 is a cross section of the working end of the surgical manipulator of FIG.", "5 taken along line 6-6.FIG.", "7 is another cross section of the working end of the surgical manipulator of FIG.", "5.FIG.", "8 is another view of the control interface of the surgical manipulator of FIG.", "4 shown in a different position.", "FIG.", "9 is an enlarged perspective view of the control interface of the surgical manipulator of FIG.", "1.FIG.", "10 is a cross section of the control interface of FIG.", "9 taken along line 10-10.FIG.", "11 is a cross section of the control interface of FIG.", "9 taken along line 11-11.FIG.", "12 is a cross section of the control interface of FIG.", "9 taken along line 12-12.FIG.", "13 is a rear perspective view of a portion of the surgical manipulator of FIG.", "1.FIG.", "14 is a side view of a second construction of a surgical manipulator in accordance with the invention.", "FIG.", "15 is a cross section view of a portion of the surgical manipulator of FIG.", "14.FIG.", "16 is a side perspective view of a third construction of a surgical manipulator in accordance with the invention.", "FIG.", "17 is a side view of a fourth construction of a surgical manipulator in accordance with the invention.", "FIG.", "18 is an enlarged view of a working end of the surgical manipulator of FIG.", "17.FIG.", "19 is an enlarged view of the working end of the surgical manipulator of FIG.", "17 in a different position.", "FIG.", "20 is a top view of a straight position of the working end of FIG.", "17.FIG.", "21 is another top view of a bent position of the working end of FIG.", "17.FIG.", "22 is a perspective and cross-section view of the working end of FIG.", "18 taken through line 22-22.FIG.", "23 is a perspective view of a portion of a control interface of the surgical manipulator of FIG.", "17.FIG.", "24 is an enlarged view of the a portion of the control interface of FIG.", "23.FIG.", "25 is an enlarged view of a portion of the control interface of the surgical manipulator of FIG.", "17.FIG.", "26 is an enlarged view of another portion of the control interface of the surgical manipulator of FIG.", "17.FIG.", "27 is an enlarged view of another portion of the control interface of the surgical manipulator of FIG.", "17.FIG.", "28 is a perspective view of the surgical manipulator of FIG.", "17 in use for throat surgery.", "FIG.", "29 is an enlarged view of two surgical manipulators in use for throat surgery.", "FIG.", "30 is an illustration of a virtual pivot.", "DETAILED DESCRIPTION Before any embodiments of the invention are explained in detail, it is to be understood that the invention is not limited in its application to the details of construction and the arrangement of components set forth in the following description or illustrated in the following drawings.", "The invention is capable of other embodiments and of being practiced or of being carried out in various ways.", "FIG.", "1 illustrates a dexterous surgical manipulator 10 according to one embodiment of the present invention.", "The manipulator 10 includes an internal working end 12 and an external control interface 14 connected to the internal working end 12 by a main shaft 16.“Internal” generally indicates a portion of the manipulator 10 that enters the human body through an opening while “external” generally indicates a portion of the manipulator 10 that remains outside of the human body.", "A center line F is defined along the surgical manipulator 10, as shown.", "The main shaft 16 is rigid and is formed of a suitable rigid material, such as carbon fiber or stainless steel and has a diameter of approximately 4 mm.", "The internal working end 12 also preferably has a diameter, measured perpendicular to the center line F, of approximately 4 mm.", "In other constructions, the size of the surgical manipulator 10 may be scaled as desired.", "Furthermore, a length of the main shaft 16 may be chosen to suit a particular application, as desired.", "With particular reference to FIG.", "3, the internal working end 12 includes an internal elbow joint 18 adjacent the main shaft 16, an internal forearm 20 adjacent the internal elbow joint 18, an internal wrist 24 positioned adjacent the internal forearm 20, an internal wrist joint 22 positioned between the internal forearm 20 and the internal wrist 24, and a gripper 26 positioned adjacent the internal wrist 24 including a first gripper finger 28 and a second gripper finger 30.With particular reference to FIGS.", "5-7, the first gripper finger 28 includes a first gripper pulley 32 for receiving a first drive cable 36, and the second gripper finger 30 includes a second gripper pulley 34 for receiving a second drive cable 38, as will be described in greater detail below.", "A pulley, as defined herein, is a generally curved or angled surface for receiving a cable thereabout to change the direction of the cable.", "In the illustrated construction, the pulleys 32, 34 are generally circular or semi-circular shaped surfaces having a groove therein for receiving the respective cable 36, 38 thereabout, as shown in FIG.", "7.In other constructions, the pulleys described herein may have other suitable shapes and configurations.", "The first gripper finger 28 includes an aperture 40a for receiving a gripper pivot pin 42, and the second gripper finger 30 includes an aperture 40b for receiving the gripper pivot pin 42.The internal wrist 24 includes a wrist pulley 44 and a pair of ears 46a, 46b.", "The wrist pulley 44 and ears 46a, 46b are connected by a central portion 48.The pair of ears 46a, 46b include an aperture 40c therethrough for receiving the pivot pin 42.The apertures 40a, 40b and 40c are aligned coaxially along a gripper pivot axis A defined by the gripper pivot pin 42, the apertures 40a, 40b and 40c aligning to effectively form a single aperture 40 (FIG.", "7) for receiving the gripper pivot pin 42.The first and second gripper pulleys 32, 34 are centered about the gripper pivot axis A.", "The first and second gripper fingers 28, 30 and the internal wrist 24 are pivotably coupled by the pivot pin 42.The wrist pulley 44 includes an aperture 52a therethrough for receiving a wrist pivot pin 50 defining a wrist pivot axis B.", "The wrist pulley 44 is a generally circular or semi-circular shaped surface having a groove therein for receiving a third drive cable 54 therearound, as shown in FIG.", "6 and which will be described in greater detail below.", "The internal forearm 20, positioned adjacent the wrist pulley 44 at a first axial end, is a generally cylindrical structure including an aperture 52b at one end receiving the wrist pivot pin 50 therethrough.", "The apertures 52a and 52b are aligned coaxially.", "The internal wrist joint 22 is generally defined by the wrist pulley 44 being pivotably connected to the internal forearm 20 by way of the wrist pivot pin 50.The internal forearm 20 includes first cable passages 56 (FIG.", "7) and second cable passages (not shown) for receiving the first and second drive cables 36, 38, respectively, and third cable passages 58 (FIG.", "6) for receiving the third drive cable 54.The second cable passages are generally mirror images of the first cable passages 56 positioned on an opposite side of the internal forearm 20.The cable passages 56, 58 extend generally axially, substantially parallel with the center line F, between a first axial end adjacent the wrist pulley 40 and a second axial end adjacent the internal elbow joint 18.With particular reference to FIG.", "5, the elbow joint 18 includes first, second and third elbow pieces 60a, 60b, 60c, respectively.", "The first elbow piece 60a is pivotably coupled to the second axial end of the internal forearm 20 by a first elbow pivot pin 62 defining a first elbow pivot axis C1.The third elbow piece 60c is pivotably coupled to the second elbow piece 60b by a second elbow pivot pin 64 defining a second elbow pivot axis C2.The first elbow pivot pin 62 is parallel to the second elbow pivot pin 64.Likewise, the first elbow pivot axis C1 is parallel to the second elbow pivot axis C2.Pivot axes C1 and C2 cooperate to define a single degree of freedom of the internal elbow joint 18.The first elbow piece 60a is coupled to the second elbow piece 60b by a third elbow pivot pin 66 defining a third elbow pivot axis E. The third elbow pivot pin 66 is substantially perpendicular to the first and second elbow pivot pins 62, 64.Likewise, the third elbow pivot axis E is substantially perpendicular to the first and second elbow pivot axes C1, C2.Thus, the third elbow pivot axis E defines a second degree of freedom of the internal elbow joint 18.The elbow joint 18 also includes apertures generally axially therethrough, substantially parallel to the center line F, further defining the first, second and third cable passages 56, 58 (the second cable passages not shown) for receiving the first, second and third drive cables 36, 38, 54, respectively.", "With reference to FIG.", "4, the external control interface 14 includes an external elbow 68 coupled to an end of the main shaft 16 opposite the internal working end 12, an external forearm 70 coupled to the external elbow 68, a compensation mechanism 72 coupled to the external forearm 70, a stub link 82 coupled to the compensation mechanism 72, an external wrist 74 coupled to the stub link 82, an external wrist joint 76 between the stub link 82 and the external wrist 74, a user control 80 coupled to the external wrist 74 and a finger control joint 78 between the user control 80 and the external wrist 74.The external elbow 68 includes a middle elbow disc 84 coupled to the main shaft 16 by a first external elbow pin 86 on one side and coupled to the external forearm 70 by a second external elbow pin 88 on another side opposite the first side.", "The first and second external elbow pins 86, 88 are substantially parallel to each other, thus defining a degree of freedom of movement of the external elbow 68.The middle elbow disc 84 is also coupled to the main shaft 16 by a third external elbow pin (not shown) that extends substantially perpendicular to the first external elbow pin 86, forming a first universal joint, and is also coupled to the external forearm 70 by a fourth external elbow pin (not shown) that is substantially perpendicular to the second external elbow pin 88, forming a second universal joint.", "Thus, the external elbow 68 has a first degree of freedom defined by the first and second external elbow pins 86, 88 (i.e., the first universal joint) and a second degree of freedom defined by the third and fourth external elbow pins (i.e., the second universal joint).", "The external elbow 68 includes apertures 90 extending generally axially, substantially parallel with the center line F, further defining the first, second and third cable passages 56, 58.The external forearm 70 also includes apertures (not shown) extending generally axially, substantially parallel with the center line F, further defining the first, second and third cable passages 56, 58.The third cable passage 58 and the third drive cable 54 are twisted 180 degrees inside the external forearm 70.The compensation mechanism 72 is best illustrated in FIG.", "8 and includes a secondary joint 92 positioned between the stub link 82 and the external forearm 70 and a cable 94 connecting the stub link 82 to the external elbow 68 via the secondary joint 92, as shown.", "The cable 94 is mounted a first distance M from the centerline F proximate the secondary joint 92, and is mounted a second distance N from the centerline F proximate the external elbow 68.The second distance N is twice the first distance M. In the illustrated construction, a change in angle of the external elbow 68 causes twice the change in angle of the secondary joint 92.For example, when the external elbow 68 is flexed 10 degrees, the secondary joint flexes twice as much, i.e., 20 degrees.", "Thus, the secondary joint 92 and the external elbow 68 are linked by the cable 94.That is, movement of the external elbow 68 causes movement of the secondary joint 92.More specifically, movement of the external elbow 68 causes twice the movement in the secondary joint 92.In other constructions, other distances may be employed.", "For example, the second distance may be one and a half times the first distance, or three times the first distance, etc.", "This relationship achieves a desired compensation by choosing a ratio of relative movement such that a movement of the external elbow 68 causes a larger movement of the secondary joint 92.The purpose of the compensation mechanism will be explained in further detail below.", "The stub link 82 is coupled to the compensation mechanism 72 at one end and at an opposite end includes an aperture 96 for receiving an external wrist pin 98 defining an external wrist pivot axis G. The external wrist 74 includes an aperture 100 receiving the external wrist pin 98, thus pivotably coupling the stub link 82 to the external wrist 74.The aperture 96 is aligned coaxially with the aperture 100.The external wrist joint 76 is generally defined by the stub link 82 including the aperture 96, the external wrist 74 including the aperture 100 and the external wrist pin 98 passing through the apertures 96, 100.The external wrist 74 includes a pulley 102 and a termination area 104 in which the third drive cable 54 is terminated.", "In the illustrated construction, the pulley 102 receives the drive cable 54 and two free ends of the drive cable 54 are secured and fixed to the termination area 104 of the external wrist 74.The external wrist 74 is pivotably coupled to the stub link 82 at one end and at an opposite end includes an aperture 106 for receiving an external gripper pin 108 defining an external gripper axis H. The external control interface 14 includes a user control 80.The user control 80 includes first and second gripper levers 110, 112, respectively.", "The first and second gripper levers 110, 112 are pivotably coupled to each other and to a support member 114 by a lever pin 116 defining a lever axis J.", "Each of the first and second gripper levers 110, 112 are independently pivotable with respect to the support member 114 and are biased away from the support member 114 to an open position by respective springs 111, 113 disposed between the first and second gripper levers 110, 112 and the support member 114, respectively.", "The support member 114 is coupled to the gripper levers 110, 112 at a first end and is coupled to the external wrist by way of the external wrist pin 98 at a second end opposite the first end.", "The first gripper lever 110 is pivotably connected to a first link 118, which is in turn pivotably connected to a first cable box 120, which is in turn pivotably connected to the external wrist 74 by way of the external wrist pin 98.Likewise, the second gripper lever 112 is pivotably connected to a second link 122, which is in turn pivotably connected to a second cable box 124, which is in turn pivotably connected to the external wrist 74 by way of the external wrist pin 98.Thus, the first and second cable boxes 120, 124 are pivotable about the external wrist pin 98 independently of each other.", "Furthermore, the first and second cables 36, 38 are routed around the wrist joint (FIG.", "12).", "Changes in length of the cables 36, 38 in the area proximate the external wrist pin 98 are a result of articulation of the wrist joint 76.They are mirrored by similar changes at the gripper end of the device, as will be explained in greater detail below.", "Thus, the position of the gripper fingers 28, 30 should be unaffected by articulation of the external wrist joint 76.As best shown in FIG.", "10, the first cable box 120 and the second cable box 124 (not shown in FIG.", "10) include a pulley 126 and a termination area 128.The first and second cable boxes 120, 124 also include optional first and second spring cavities 130, 132 extending parallel to each other and receiving first and second springs 134, 136, respectively.", "The second cable box 124 is substantially the same as the first cable box 120 and is therefore not illustrated in cross-section, although a pulley 138 of the second cable box 124 can be seen in the cross section of FIG.", "12.With further reference to FIG.", "10, the pulley 126 receives the first drive cable 36 thereabout.", "The first drive cable 36 includes two free ends, each of which is secured and fixed in the termination area 128 of the first cable box 120.The free ends of the drive cable 36 are optionally coupled to the first and second springs 134, 136, respectively, for maintaining a level of tension on the drive cable 36.Likewise, the pulley 138 (FIG.", "12) in the second cable box 124 receives the second drive cable 38 thereabout.", "The second drive cable 38 includes two free ends, each of which is secured and fixed in the termination area (not shown) of the second cable box 124 and may optionally be secured to springs, as described above.", "FIG.", "13 illustrates the surgical manipulator 10 having a transparent main shaft 16 for illustration purposes.", "Inside the main shaft 16 is a core spacer 140 which carries the first, second and third drive cables 36, 38, 54 from the internal elbow 18 to the external elbow 68.The core spacer 140 includes a twist of 180 degrees with respect to the centerline F, which causes each of the drive cables 36, 38, 54 to twist 180 degrees with respect to the centerline F between the internal elbow 18 to the external elbow 68.For example, a cable that passes through the internal elbow 18 at the top of the joint will pass through the external elbow 68 at the bottom of the joint.", "Each cable 36, 38, 54 is received inside a respective sleeve pair 142, 144, 146 (FIG.", "5) extending from the internal elbow 18 through the main shaft 16 to the external elbow 68.The sleeves 142, 144, 146 may be made of nickel titanium, or another suitable material.", "Each cable 36, 38, 54 originates at the external control interface end 14, loops around a pulley at the internal working end 12, and returns to the external control interface end 14, thus necessitating a pair of sleeves for each cable 36, 38, 54, one for a portion of the cable on one side of the respective pulley and one for a portion of the cable on the other side of the respective pulley.", "Each sleeve 142, 144, 146 is secured at a first end to the internal forearm 20, as shown in FIG.", "5, and secured at a second end to the external forearm 70.Thus, the sleeves 142, 144, 146 provide a path for the cables 36, 38, 54 to follow that has a constant length, regardless of the orientation of the internal and external elbow joints 18, 68, such that actuation of the cables 36, 38, 54 for driving the first and second gripper fingers 28, 30 and the internal wrist joint 22 is independent from actuation of the internal elbow joint 18.Furthermore, the sleeves 142, 144, 146 themselves act as drive cables to actuate the internal elbow joint 16 in response to movement of the external elbow 68.This provides dual functionality for the sleeves 142, 144, 146: carrying the cables 36, 38, 54 and operably connecting the internal and external elbows 18, 68.The sleeves 142, 144, 146 are twisted 180 degrees with respect to the center line F by the core spacer 140.FIG.", "2 schematically illustrates the angular relationship between linkages of the surgical manipulator 10.An external gripper angle A1 is defined between the user control 80 and the external forearm 70.An external elbow angle A2 is defined between the external forearm 70 and the main shaft 16.An internal elbow angle A3 is defined between the main shaft 16 and the internal forearm 20.An internal gripper angle A4 is defined between the internal forearm 20 and the gripper 26.The design intent is to keep the user control 80 and the gripper 16 parallel.", "In order to keep the user control 80 and the gripper 16 parallel, the following equation must be satisfied: A4=A1−(A3+A2).", "It is known, by design, that the internal and external elbow angles A3 and A2 are equal in magnitude.", "Therefore, in order to keep the user control 80 and the gripper 16 parallel, the mechanics of the surgical manipulator 10, 150 must be such that the gripper angle A4 depends upon, i.e., is controlled by, both the external gripper angle A1 and the and the external elbow angle A2.In other words, the mechanics of the surgical manipulator 10 must be such that the external gripper angle A1 and the external elbow angle A2 are linked or connected in such a way that ensures that the equation is satisfied.", "The compensation mechanism 72 provides the needed relationship.", "In operation, the surgical manipulator 10 is used by a surgeon as a tool during surgery.", "The shaft 16 of the surgical manipulator 10 can be placed to pass from outside of a patient's body to the inside of a patient's body such that the internal working end 12 is positioned inside the patient's body.", "For example, as shown in FIGS.", "28-29, a laryngoscope 162 is placed in a patient's mouth/throat and the shaft 16 is mounted in the laryngoscope 162.An endoscope 164 (FIG.", "29) may also be passed through the laryngoscope 162.The surgeon manipulates the external control interface (shown as a different construction) in order to manipulate the position of the gripper 26 at the end of the internal working end 12 in order to perform a desired operation, such as gripping a needle or performing a stitch.", "The surgical manipulator 10 may similarly be used in laparoscopic surgery.", "The first gripper finger 28 is individually controlled by the first gripper lever 110 and the second gripper finger 30 is individually and independently controlled by the second gripper lever 112.The first drive cable 36 is coupled between the first cable box 120 and the first pulley 32.When the first gripper lever 110 is squeezed towards the support member 114, the first cable box 120 pivots about the external gripper axis H. As both free ends of the first drive cable 36 are terminated and fixed to the first cable box 120 (FIG.", "10), when the first cable box 120 pivots about the external gripper axis H, the first cable box 120 pulls one free end of the first drive cable 36 and feeds the other free end of the first drive cable 36 within the surgical manipulator 10.This causes the first pulley 32 to rotate about the gripper pivot axis A, causing rotation of the entire first gripper finger 28 about the pivot axis A.", "For example, when the surgeon squeezes the first gripper lever 110 towards the support member 114, the first cable box 120 pivots towards the support member 114, which pulls a free end 36a of the first cable 36 shown in light red (top) and feeds a free end of the cable 36b shown in dark red (bottom).", "Since the cable 36 is twisted 180 degrees inside the main shaft 16, the top portion of the cable 36 about the pulley 32 (FIG.", "7) is given slack and the bottom portion of the cable 36 is pulled, thus rotating the first gripper finger 28 towards the second gripper finger 30 towards a closed position.", "The same description applies to the movement of the second gripper finger 30.Thus, squeezing the first and second gripper levers 110, 112 towards each other, i.e., towards the support member 14, causes the gripper 26 to close.", "This mapping of motion is intuitive to the user.", "Furthermore, the lever pivot axis J is positioned at the back of the external control interface 14, behind the first and second gripper levers 110, 112.In other words, the first and second gripper levers 110, 112 are located between the lever pivot axis J and the internal working end 12 in the direction of the center line F. Furthermore, the first and second gripper levers 110, 112 are substantially symmetric about the center line F, both vertically symmetric and left-and-right symmetric.", "This provides an ambidextrous user control 80.The internal elbow joint 18 is controlled by the external elbow 68.To control the internal elbow joint 18, the surgeon flexes the external elbow 68.The internal elbow joint 18 and the external elbow 68 are coupled to each other by the sleeve pairs 142, 144, 146.The sleeve pairs 142, 144, 146 twist 180 degrees inside the main shaft 16 with respect to the center line F. Therefore, when the surgeon flexes the external elbow 68 down, as shown in FIGS.", "1-2, such that the external forearm 70 forms the angle A2 with the main shaft 16, the internal elbow joint A3 also flexes down such that the internal forearm 20 forms the angle A3 with the main shaft 16, the angles A2 and A3 being substantially equal.", "The secondary joint 92 is constrained by the compensation mechanism 72 to flex twice as much as the external elbow 68.Therefore, when the surgeon flexes the external elbow 68, the compensation mechanism 72 also flexes.", "The internal gripper angle A4 is thus controlled by both the external elbow angle A2 and the external gripper angle A1 such that the gripper 26 remains substantially parallel to the user control 80.As the sleeve pairs 142, 144, 146 are coupled between the internal and external forearms 20, 70 and span the entire length of both the internal and external elbow joints 18, 68, the path length of the cables 36, 38 54 is not changed by flexing of the internal and external elbow joints 18, 68.Therefore, elbow joint control is independent from all other control of the internal working end 12 with one exception: because the compensation mechanism 72 links movement of the external elbow 68 with movement of the secondary joint 92 and thus with the angle A1 of the user control 80, the angle A4 of the gripper 26 is dependent, albeit not directly, on the angle A2 of the external elbow 68 as well as the angle A1 of the user control 80.Thus, the compensation mechanism 72 helps the surgical manipulator 10 satisfy the equation to keep the gripper 26 substantially parallel to the user control 80.This mapping is intuitive for the user.", "The internal wrist joint 22 is controlled by the external wrist 74 pivoting about the external wrist pivot axis G. The third drive cable 54 is coupled between the wrist pulley 44 (FIG.", "6) and the external wrist pulley 102 (FIG.", "11).", "Since the third cable 54 is twisted 180 degrees inside the main shaft 16 and subsequently untwisted inside the external forearm 70, the external wrist 74 and internal wrist 24 move in a parallel manner.", "That is, when the external wrist 74 is pivoted counterclockwise about the external wrist pivot axis G, the internal wrist 24 is also pivoted counterclockwise about the wrist pivot axis B such that the internal wrist 24 is substantially parallel with the external wrist 74.As both free ends of the third drive cable 54 are terminated and fixed to the external wrist 74 (FIG.", "11), when the external wrist 74 pivots about the external wrist pivot axis G, the external wrist 74 pulls one free end of the third drive cable 54 and feeds the other free end of the third drive cable 54 within the external wrist 74.This causes the wrist pulley 44 to rotate about the wrist pivot axis B, causing rotation of the internal wrist 24 and the gripper 26 about the wrist pivot axis B.", "For example, when the surgeon pivots the user control 80 and the external wrist 74 about the wrist pivot axis G in a clockwise direction as viewed from the top (or counterclockwise direction as viewed from the bottom, e.g., FIG.", "6), a free end 54a of the third cable 54 shown in dark red is pulled and a free end of the cable 54 shown in light red is fed.", "Therefore, a portion of the cable 54 on one side the pulley 102 (FIG.", "11) is given slack and the other portion of the cable 54 is pulled, rotating the wrist pulley 44.This mapping of motion is intuitive to the user.", "Furthermore, the wrist pivot axis G (and the external wrist joint 76) is positioned within the user control 80 and is therefore positioned inside a grip volume 73 of a surgeon's hand (FIG.", "8) when gripping and operating the user control 80.For example, the surgeon's hand may grip the first and second gripper levers 110, 112.In some constructions, the surgeon's hand may grip a first pivotable lever (e.g., the first gripper lever 110 or the second gripper lever 112) and a second stationary lever (e.g., the other of the first gripper lever 110 and the second gripper lever 112 being configured as non-pivotable), the first pivotable lever pivoting with respect to the second stationary lever.", "As illustrated in FIG.", "8, the external wrist joint 76 can also be defined as being located within a spherical grip volume 75 including the first and second gripper levers 110, 112.As can be seen in FIGS.", "4 and 9-11, the wrist pivot axis G intersects the user control 80, and more specifically intersects at least the first gripper lever 110.Positioning the wrist pivot axis G within the grasp of an operator provides intuitive mapping of motion.", "In other constructions, a sliding mechanism having a virtual pivot 360 could be used, as illustrated in FIG.", "30.The virtual pivot point 362 would also lie within the grip of a user's hand.", "As shown in FIG.", "12, when the wrist joint 24 at axis G is manipulated, the length of the first and second cables 36, 38 (gripper control cables) changes in the area indicated by numeral 166; however, an equal and opposite change in length occurs in each of the gripper control cables 36, 38 at the internal working end 12 of the manipulator 10 because the wrists 24, 74 are parallel.", "Therefore, articulation of the wrist joint 24 at axis G does not affect the position of the gripper fingers 28, 30 with respect to each other.", "Thus, the internal working end 12 of the surgical manipulator 10 has seven degrees of freedom.", "As illustrated in FIG.", "1, a first degree of freedom D1 is a sliding motion of the entire dexterous manipulator 10 in a direction parallel with the main shaft 16 caused by the surgeon pushing or pulling the dexterous manipulator 10 in said direction.", "A second degree of freedom D2 is a rotational motion of the entire dexterous manipulator 10 caused by the surgeon rotating the dexterous manipulator 10 about the centerline F of the main shaft 16.A third degree of freedom D3 is the pivoting of the internal elbow joint 18 about the elbow pivot axes C1 and C2 caused by the surgeon pivoting the external elbow 68 about a parallel axis.", "A fourth degree of freedom D4 is the pivoting of the internal elbow joint 18 about the third elbow pivot axis E, which is substantially perpendicular to the elbow pivot axes C1 and C2, caused by the surgeon pivoting the external elbow 68 about an axis substantially parallel with the third elbow pivot axis E. A fifth degree of freedom is the pivoting of the wrist about the wrist pivot axis B, which is caused by the surgeon pivoting the external wrist 74 about the external wrist pivot axis G. A sixth degree of freedom is the pivoting of the first gripper finger 28 about the gripper pivot axis A, and a seventh degree of freedom is the pivoting of the second gripper finger 30 about the gripper pivot axis A.", "As each gripper finger 28, 30 is controlled independently by a respective gripper lever 110, 112, each has its own degree of freedom.", "FIGS.", "14-15 illustrate an alternate construction of a dexterous surgical manipulator 150.The surgical manipulator 150 includes the same internal working end 12 and main shaft 16 as described above with respect to FIGS.", "1-13.The surgical manipulator 150 includes an external control interface 152 that differs from the external control interface 14 described above with respect to FIGS.", "1-13 in that the compensation mechanism 72, including the secondary joint 92 and the cable 94, and the stub link 82 have been eliminated.", "As such, the external wrist 74 is pivotably coupled to the external forearm 70.The remaining elements of the dexterous surgical manipulator 150 are substantially the same as those described above with respect to FIGS.", "1-13 and need not be described again.", "FIG.", "15 illustrates a compensation mechanism 154 for the surgical manipulator 150.The compensation mechanism 154 provides the needed relationship between the internal gripper angle A4, the external gripper angle A1 and the external elbow angle A2, described above.", "The compensation mechanism 154 is embodied by the sleeves 142, 144, 146 being terminated and secured in the middle elbow disc 84, leaving the cables 36, 38, 54 exposed in a space 148 between the middle elbow disc 84 and the external forearm 70.Thus, the space between the middle elbow disc 84 and external forearm 70 changes with changes in the angle of the external elbow joint 68.As the cables 36, 38, 54 are not housed in sleeves within the space 148, the cable path length changes as the angle of the external elbow joint 68 changes.", "Therefore, the movement of the gripper 26 is at least partially dependent on the angle of the external elbow joint 68, as needed to satisfy the equation described above.", "In operation, the surgical manipulator 150 works similarly to the surgical manipulator 10, described above, and the similar functions will not be described again.", "The surgical manipulator 150 functions differently from the surgical manipulator 10 in that the external elbow 68 is constructed such that the sleeve pairs 142, 144, 146 do not span the entire length of the external elbow joint 68.Rather, the sleeve pairs 142, 144, 146 terminate at the middle elbow disc 84.As a result, the path lengths of the cables 36, 38, 54 are elongated when the external elbow 68 is flexed and shortened when the external elbow 68 is unflexed.", "Therefore, the position of the gripper 26 (the gripper angle A4) is affected when the external elbow 68 is flexed.", "Thus, the internal gripper angle A4 is dependent on the position of the external elbow 68 (external elbow angle A2) and on the angle A1 of the user control 80.Thus, the compensation mechanism 154 helps the surgical manipulator 150 satisfy the equation, described above, to keep the gripper 26 substantially parallel to the user control 80.This mapping is intuitive for the user.", "The gripper control for the gripper 26 of the surgical manipulator 150 is identical to the control described above with respect to the surgical manipulator 10.The wrist control for the internal wrist 24 of the surgical manipulator 150 is identical to the control described above with respect to the surgical manipulator 10.FIG.", "16 illustrates yet another alternate construction of a dexterous surgical manipulator 156.The surgical manipulator 156 includes the same main shaft 16 as described above with respect to FIGS.", "1-13 and includes an internal working end 158 and an external control interface 160.The internal working end 158 is substantially the same as the construction described above with respect to FIGS.", "1-13 except that the internal forearm 20 and the internal elbow joint 18 are eliminated.", "As such, the internal wrist 24 is pivotably coupled to the main shaft 16.The external control interface 160 is substantially the same as the construction described above with respect to FIGS.", "1-13 except that the external elbow, external forearm 70, compensation mechanism 72 and stub link 82 have been eliminated.", "As such, the external wrist 74 is pivotably coupled to the main shaft 16.Remaining elements of the dexterous surgical manipulator 156 are substantially the same as those described above with respect to FIGS.", "1-13 and need not be described again.", "In operation, the surgical manipulator 156 functions substantially the same as the surgical manipulator 10, as described above, except that there is no elbow control and elbow movement.", "Therefore, no compensation mechanism is necessary.", "The gripper control for the gripper 26 of the surgical manipulator 156 is identical to the control described above with respect to the surgical manipulator 10.The wrist control for the internal wrist 24 of the surgical manipulator 156 is identical to the control described above with respect to the surgical manipulator 10.The surgical manipulator 156 may include a pivot ring 168 positioned about the main shaft 16 that allows the surgeon to push and pull the surgical manipulator 156, defining a degree of freedom, and to pivot the surgical manipulator 156 about the pivot ring 168, defining another degree of freedom.", "FIGS.", "17-27 illustrate another construction of a dexterous surgical manipulator 210 including an internal working end 212 and an external control interface 214 connected to the internal working end 212 by a main shaft 216.A center line F′ is defined along the center of the surgical manipulator 10, as shown.", "The main shaft 216 is rigid and is formed of a suitable rigid material, such as carbon fiber or stainless steel and has a diameter of approximately 4 mm.", "The internal working end 212 also preferably has a diameter, measured perpendicular to the center line F′, of approximately 4 mm.", "In other constructions, the size of the surgical manipulator 210 may be scaled as desired.", "Furthermore, a length of the main shaft 216 may be chosen to suit a particular application, as desired.", "With particular reference to FIGS.", "18-22, the internal working end 212 includes an internal elbow joint 218 adjacent the main shaft 216, an internal forearm 220 adjacent the internal elbow joint 218, an internal wrist 224 positioned adjacent the internal forearm 220, an internal wrist joint 222 positioned between the internal forearm 220 and the internal wrist 224, and a gripper 226 positioned adjacent the internal wrist 224 including a first gripper finger 228 and a second gripper finger 230.The first gripper finger 228 includes a first gripper pulley 232 for receiving a first drive cable 236, and the second gripper finger 230 includes a second gripper pulley 234 for receiving a second drive cable 238, as will be described in greater detail below.", "In the illustrated construction, the pulleys 232, 234 are generally circular or semi-circular shaped surfaces having a groove therein for receiving the respective cable 236, 238 thereabout, as shown in FIGS.", "20-22.In other constructions, the pulleys described herein may have other suitable shapes and configurations.", "The first gripper finger 228 is pivotably coupled to the internal wrist 224 by a gripper pivot pin 242, and the second gripper finger 230 is pivotably coupled to the internal wrist 224 by the gripper pivot pin 242, which defines a gripper pivot axis A′ (FIG.", "18).", "An aperture 240 passing through the first and second gripper fingers 228, 230 and the internal wrist 224 receives the gripper pivot pin 242.The first and second gripper pulleys 232, 234 are centered about the gripper pivot axis A′.", "The first and second gripper fingers 228, 230 and the internal wrist 224 are pivotably coupled by the pivot pin 242.The internal forearm 220, positioned adjacent the internal wrist 224 at a first axial end, is a generally cylindrical structure.", "The internal forearm 220 and the internal wrist 224 are pivotably coupled by a wrist pivot pin 250 defining a wrist pivot axis B′.", "The internal wrist joint 222 is generally defined by the internal wrist 224 being pivotably connected to the internal forearm 220 by way of the wrist pivot pin 250.The internal forearm 220 includes first cable passages 256 (FIG.", "19) and second cable passages (not shown) for receiving the first and second drive cables 236, 238, respectively.", "The second cable passages are generally mirror images of the first cable passages 56 positioned on an opposite side of the internal forearm 220.The cable passages 56 axially, substantially parallel with the center line F, between a first axial end adjacent the internal wrist 240 and a second axial end adjacent the internal elbow joint 218.With particular reference to FIG.", "18, the elbow joint 218 includes the main shaft 216 pivotably coupled to the internal forearm 220 by a first elbow pivot pin 262 defining a first elbow pivot axis C′, providing the elbow joint 218 with a first degree of freedom.", "The elbow joint 218 also includes the main shaft 216 pivotably coupled to the internal forearm 220 by a second elbow pivot pin 266 defining a third elbow pivot axis E′, providing the elbow joint 218 with a second degree of freedom.", "The second elbow pivot pin 266 is substantially perpendicular to the first elbow pivot pin 262.Likewise, the second elbow pivot axis E′ is substantially perpendicular to the first elbow pivot axis C′.", "With reference to FIGS.", "23-29, the external control interface 214 includes an external elbow 268 (FIG.", "27) coupled to an end of the main shaft 216 opposite the internal working end 212, an external forearm 270 coupled to the external elbow 268, a compensation mechanism 272 located in the external forearm 270 proximate the external elbow 268, an external wrist 274 coupled to the external forearm 274, a wrist joint 276 between the external forearm 270 and the external wrist 274, a user control 280 coupled to the external wrist 274 and a finger control joint 278 between the user control 280 and the external wrist 274.The external control interface 214 includes a plurality of idler pulleys 356 for directing the first and second cables 236, 238 substantially along the center line F (FIGS.", "25-27).", "With particular reference to FIG.", "27, the external elbow 268 includes an elbow piece 284 fixedly coupled to the main shaft 216.The elbow piece 284 is pivotably coupled to the external forearm 270 by a first external elbow pin 286, thus defining a first degree of freedom of movement of the external elbow 268.The first external elbow pin 286 defines a first external elbow pivot axis K′.", "The elbow piece 284 is also coupled to the external forearm 270 by a second external elbow pin 288 that extends substantially perpendicular to the first external elbow pin 286.The second external elbow pin 288 defines a second external elbow pivot axis L′, which is substantially perpendicular to the first external elbow pivot axis K′.", "Thus, the external elbow 268 has a first degree of freedom defined by the first external elbow pin 286 and a second degree of freedom defined by the second external elbow pin 288.The external elbow 268 includes openings 290 extending generally axially, substantially parallel with the center line F, further defining the first and second cable passages 256, 258.The external forearm 270 also includes passages extending generally axially, substantially parallel with the center line F, further defining the first and second cable passages 256, 258.The compensation mechanism 272 is best illustrated in FIG.", "27 and includes a gimbaled plate 292 supporting pulleys 348, 350 for redirecting the cables 236, 238 from the external elbow 268 to the external forearm 270.The compensation mechanism 272 also includes pull rods 352, 354 coupled to the gimbaled plate 292 and to the main shaft 216.Movement of the external elbow 268 pushes and pulls the rods 352, 354 with respect to the exterior forearm 270, which pivots the gimbaled plate 292 to move the pulleys 348, 350, respectively.", "Moving the pulleys increases or decreases the path length of the respective cables 236, 238, effectively pulling or giving slack to the cables, which adjusts the gripper 226 and internal wrist 224 to compensate for movements in the external elbow 268.With reference to FIG.", "24, the external forearm 270 is pivotably coupled to the external wrist 274 by an external wrist pin 298 defining an external wrist pivot axis G′.", "The wrist joint 276 is generally defined by the external forearm 270 being pivotably coupled to the external wrist 274 by the external wrist pin 298.The external wrist 274 is pivotably coupled to the external forearm 270 at one end and at an opposite end is pivotably coupled to a first gripper lever 310 and a second gripper lever 312 by an external gripper pin 308, defining an external lever pivot axis J′.", "Each of the first and second gripper levers 310, 312 are independently pivotable with respect to the external wrist 274.The first gripper lever 310 includes a pulley 326 for receiving the first drive cable 236 thereabout, and the second gripper lever 312 includes a pulley 338 for receiving the second drive cable 238 thereabout.", "The first gripper lever 310 includes a termination area 328 in which the first drive cable 236 is terminated and secured.", "The second gripper lever 312 includes a termination area 340 in which the second drive cable 238 is terminated and secured.", "When the first gripper lever 310 is pivoted about the lever pivot axis J′, the pulley 326 pulls the first drive cable 236 to actuate the first gripper finger 228.When the second gripper lever 312 is pivoted about the lever pivot axis J′, the pulley 338 pulls the second drive cable 238 to actuate the second gripper finger 230.When the external wrist 274 is pivoted about the axis G′ in a first direction, the first drive cable 236 is pulled and the second drive cable 238 is released, causing the internal wrist joint 222 to rotate in a first direction.", "When the external wrist 274 is pivoted about the axis G′ in a second direction opposite the first direction, the second drive cable 238 is pulled and the first drive cabled 236 is released, causing the internal wrist joint 222 to rotate in a second direction opposite the first direction, as shown in FIG.", "21.In other constructions, an external control interface may be linked to a computer, which receives input signals from the external control interface, translates the input signals into output signals, and transfers the output signals to an internal working end positioned remotely from the external control interface.", "Thus, the external control interface is not mechanically, but electronically, linked to the internal working end.", "Therefore, the term, “linked,” as used herein, can include both mechanical and electrical linkages.", "A surgical manipulator includes an internal working end and an external control interface for controlling the internal working end, the external control interface including first and second levers being pivotable about an axis and defining a grip.", "The surgical manipulator also includes a main shaft coupling the external control interface to the internal working end.", "The external control interface, the main shaft and the internal working end define a centerline.", "The grip is positioned between the axis and the internal working end with respect to the centerline.", "A surgical manipulator includes an internal working end and an external control interface for controlling the internal working end, the external control interface including first and second levers being pivotable about an axis and defining a grip.", "The grip is positioned between the internal working end and the axis.", "A surgical manipulator includes an internal working end having an internal joint and an external control interface linked to the internal working end for controlling the internal working end.", "The external control interface includes first and second levers defining a grip, and an external joint pivotable about an external axis.", "The external joint is linked to the internal joint such that the orientation of the internal joint depends on the orientation of the external joint.", "The external axis intersects the grip.", "Furthermore, the internal joint is pivotable about an internal axis.", "The surgical manipulator also includes a gripper associated with the internal working end for grasping an object, the gripper pivotable about an internal gripper axis.", "The gripper axis is substantially perpendicular to the internal axis.", "The first and second levers are pivotable about an external gripper axis for controlling the position of the gripper, and a main shaft operably and mechanically couples the external control interface to the internal working end.", "A surgical manipulator includes an internal working end having an internal joint, and an external control interface operably coupled to the internal working end for controlling the internal working end.", "The external control interface includes first and second levers defining a spherical grip volume between and including the first and second levers, and an external joint linked to the internal joint for controlling the internal joint.", "The external joint is positioned substantially within the spherical grip volume.", "A surgical manipulator includes an internal working end having an internal joint and a gripper for grasping an object, and an external control interface linked to the internal working end for controlling the internal working end.", "The external control interface includes first and second levers linked to the gripper for controlling the gripper, and an external joint linked to the internal joint for controlling the internal joint.", "The external joint is positioned substantially between the first and second levers.", "A surgical manipulator includes an internal working end having a first joint, an external control end having a second joint, and a drive cable extending between the internal working end and the external control end.", "The surgical manipulator also includes a sleeve housing the drive cable.", "The sleeve is operably coupled between the first and second joints such that movement of the second joint causes movement of the first joint by way of the sleeve.", "A surgical manipulator includes an internal working end having an internal forearm pivotably coupled to a gripper for grasping an object, and an external control interface including an external forearm coupled to a user control for controlling the gripper.", "The surgical manipulator also includes a main shaft coupling the external control interface to the internal working end, the main shaft having a first end and a second end and being pivotably coupled to the internal forearm at the first end and pivotably coupled to the external forearm at the second end.", "The user control is pivotable with respect to the external forearm and defines a first angle with respect to the external forearm.", "The external forearm is pivotable with respect to the main shaft and defines a second angle with respect to the main shaft.", "The internal forearm is pivotable with respect to the main shaft and defines a third angle with respect to the main shaft.", "The gripper is pivotable with respect to the internal forearm and defines a fourth angle with respect to the internal forearm.", "The first and second angles are controllable by a user.", "The external control interface is linked to the internal working end for controlling the internal working end such that the fourth angle is dependent upon both the first and second angles.", "A method of manipulating an object in a patient includes inserting a surgical tool through a lumen in the patient and moving the surgical tool toward the object.", "The surgical tool includes a shaft defining a longitudinal axis and having a first end and a second end, an internal forearm coupled to the first end of the shaft, an external forearm coupled to the second end of the shaft.", "The method also includes moving the internal forearm in a transverse direction with respect to the longitudinal axis forming a first angle having a first magnitude with respect to the longitudinal axis by moving the external forearm in the transverse direction and forming a second angle having substantially the same first magnitude with respect to the longitudinal axis.", "A method of manipulating an object in a patient includes inserting a surgical tool through a lumen in the patient and moving the surgical tool toward the object.", "The surgical tool includes a shaft having a first end and a second end, a first joint coupled to the first end of the shaft, an internal forearm having a first end and a second end, the first end of the internal forearm coupled to the first joint, a second joint coupled to the second end of the internal forearm, an internal wrist having a first end and a second end, the first end of the internal wrist coupled to the second joint, a gripper coupled to the second end of the internal wrist, a third joint coupled to the second end of the shaft, an external forearm having a first end and a second end, the first end of the external forearm coupled to the third joint, a fourth joint coupled to the second end of the external forearm, an external wrist having a first end and a second end, the first end of the external wrist coupled to the fourth joint, a fifth joint coupled to the second end of the external wrist, a sixth joint coupled to the fifth joint, a first lever, and a second lever.", "The method also includes manually moving one of the external forearm, the external wrist, the first lever, and the second lever, determining a magnitude and a direction of the movement of the one of the external forearm, the external wrist, the first lever, and the second lever, and communicating the magnitude and the direction of the movement of the one of the external forearm, the external wrist, the first lever, and the second lever to automated means that automatically translate the magnitude and the direction into movement of one of the internal forearm, the internal wrist, and the gripper.", "A device includes a first end and a second end having a control interface for controlling the first end, the control interface including first and second levers being pivotable about an axis and defining a grip.", "The device also includes a main shaft coupling the control interface to the first end.", "The control interface, the main shaft and the first end define a centerline.", "The grip is positioned between the axis and the first end with respect to the centerline.", "A device includes a first end and a control interface for controlling the first end, the control interface including first and second levers being pivotable about an axis and defining a grip.", "The grip is positioned between the first end and the axis.", "A device includes a first end having a first joint and a control interface linked to the first end for controlling the first end.", "The control interface includes first and second levers defining a grip, and a second joint pivotable about a first axis.", "The second joint is linked to the first joint such that the orientation of the first joint depends on the orientation of the second joint.", "The first axis intersects the grip.", "Thus, the invention provides, among other things, a dexterous surgical manipulator having an intuitive user interface.", "Various features and advantages of the invention are set forth in the following claims." ] ]
Patent_15874239
[ [ "DUAL FUNCTION SOLID STATE CONVERTER SWITCH", "A dual function solid state power converter operable from a three phase AC input current simultaneously provides; an AC or DC output current on an aircraft power cable which extends from a stowed position to provide ground power to a parked aircraft, and a low voltage DC current on a battery charging power cable which extends from a stowed position to charge batteries in nearby service vehicles.", "The power converter includes an AC to DC converter which converts the AC input current to a DC current on an internal DC bus, a DC to AC converter which converts the DC bus current to an AC current at a higher voltage and frequency, or a DC to DC converter which converts the DC bus current to a lower voltage DC, for supplying ground power by means of a connecting cable to a parked aircraft, and a DC to DC converter for converting the DC bus current to a lower voltage battery charging current on the battery charging cable.", "In an airport environment the power converter may be advantageously mounted on a passenger boarding bridge and a motion inhibit circuit may be provided to prevent movement of the boarding bridge when either the aircraft ground power cable or battery charging cable are not in a stowed position.", "The power converter may also be mounted on a wheeled cart for positioning by a tug, or installed in a remote stationary position." ], [ "1.A dual-purpose power converter operable from an applied alternating current supply and providing a primary AC output current and a secondary DC output current for use in a jetway adapted to service an aircraft parked on an associated ramp, comprising: a first cable set for connecting the primary AC output current to the aircraft; a second cable set for connecting the secondary DC output current to a ground service vehicle parked on the ramp; said second cable set having a deployed state enabling said cable to extend to the ramp to connect to said ground service vehicle, and a retracted state depending from the jetway and free and clear of the ramp; said jetway including an electrically-powered positioning system for positioning the jetway on the ramp relative to the aircraft; and a motion inhibit circuit including a switch actuated by said second cable set when said cable set is in said retracted state, for preventing movement of said jetway by said positioning system when said second cable set is not in said retracted state.", "2.A multi-purpose power converter as defined in claim 1 wherein said motion inhibit circuit comprises a switch disposed on said jetway and mechanically actuated by the position of said secondary cable set.", "3.A multi-purpose power converter as defined in claim 2 wherein said switch is actuated by the weight of said secondary cable set." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE DISCLOSURE <EOH>According to one embodiment of the present disclosure, there is provided a dual purpose power converter operable from an applied alternating current supply and providing a primary AC or DC output current for aircraft ground power and a secondary DC output current for battery charging, the power converter being adapted for use in a jetway adapted to service an aircraft parked on an associated ramp.", "The power converter includes a first cable set for connecting the primary AC or DC output current to the aircraft and a second cable set for connecting the secondary DC output current to a ground service vehicle parked on the ramp, whereby the second cable set has a deployed state enabling the cable to extend to the ramp to connect to the ground service vehicle and a retracted state depending from the jetway and free and clear of the ramp.", "The jetway includes an electrically-powered positioning system for positioning the jetway on the ramp relative to the aircraft and a motion inhibit circuit for preventing movement of the jetway when the second cable set is not retracted." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application claims benefit of U.S. Non-Provisional patent application Ser.", "No.", "13/450,562 filed Apr.", "19, 2012 which is hereby incorporated by reference in its entirety herein.", "BACKGROUND OF THE INVENTION I.", "Field of the Invention The present disclosure relates generally to electrical power management in airport environments, and more particularly, to a multi-function solid state converter which simultaneously supplies AC or DC ground power to a parked aircraft and DC battery charging current to one or more electrically-powered ground support vehicles, such as electric aircraft tugs or electric cargo loaders.", "II.", "Description of the Prior Art Ground support equipment, such as aircraft tugs or cargo loaders, has been predominantly powered by internal combustion engines that burn gasoline or diesel fuel.", "With advances in technology related to electrically powered vehicles, electrically powered ground support equipment has become more cost effective to operate and more prevalent at airports, particularly where emissions and noise are critical environmental considerations.", "While the increased use of electrically powered ground support equipment has reduced the demand for petroleum based fuels at airports, the need for charging the batteries of such equipment has imposed capacity requirements on airport electrical power distribution systems.", "Moreover, these power distribution systems often run over considerable distances, and additional electrical distribution centers have to be installed to support battery charging at multiple remote locations.", "This has undesirably added to the expense of introducing more electrically powered ground support equipment at airports.", "One way to mitigate the need for additional electrical power distribution centers at airports is to have ground support equipment battery charging accomplished by equipment that is already installed and used on a low duty cycle basis, such as, for example, the power converters used to supply ground power to parked aircraft.", "These power converters are often installed on the aircraft boarding passenger bridges used at airports to provide a walkway between parked aircraft and a terminal gate for loading unloading passengers, and are typically powered into an extended position following aircraft arrival at the gate and is returned to a retracted position just prior to aircraft departure.", "In accordance with the present disclosure, a dual-function solid-state converter, which may be advantageously mounted on a passenger boarding bridge, is provided to supply ground power to a parked aircraft and battery charging power to nearby electrically powered ground support equipment.", "One problem that may arise with charging ground support equipment from a power converter mounted on an aircraft boarding bridge is that movement of the bridge may damage parked ground support vehicles under charge and the cables supplying battery charging current to these vehicles.", "In further accord with the present disclosure, a dual function converter is provided with an electrical interlock circuit which prevents movement of the passenger bridge when the battery charging function of the converter is in use.", "Accordingly, it is a general object of the present disclosure to provide a dual function solid state power converter which, in addition to supplying ground power to parked aircraft, provides power for efficiently charging the batteries of aircraft ground support vehicles.", "It is a more specific object of the present disclosure to provide a dual function solid state converter for supplying ground power to an aircraft and power for charging batteries, which is mounted on a passenger boarding bridge and includes a circuit for inhibiting motion of the bridge when the battery charging function is in use.", "These and other objects, features and advantages of this disclosure will be more clearly understood through a consideration of the following detailed description.", "SUMMARY OF THE DISCLOSURE According to one embodiment of the present disclosure, there is provided a dual purpose power converter operable from an applied alternating current supply and providing a primary AC or DC output current for aircraft ground power and a secondary DC output current for battery charging, the power converter being adapted for use in a jetway adapted to service an aircraft parked on an associated ramp.", "The power converter includes a first cable set for connecting the primary AC or DC output current to the aircraft and a second cable set for connecting the secondary DC output current to a ground service vehicle parked on the ramp, whereby the second cable set has a deployed state enabling the cable to extend to the ramp to connect to the ground service vehicle and a retracted state depending from the jetway and free and clear of the ramp.", "The jetway includes an electrically-powered positioning system for positioning the jetway on the ramp relative to the aircraft and a motion inhibit circuit for preventing movement of the jetway when the second cable set is not retracted.", "BRIEF DESCRIPTION OF THE DRAWINGS The present disclosure will be more fully understood by reference to the following detailed description of one or more preferred embodiments when read in conjunction with the accompanying drawings, in which like reference characters refer to like parts throughout the views and in which: FIG.", "1 is a perspective view of a passenger boarding bridge having a multiple function solid state power converter mounted thereon, showing the power converter connected to supply ground power to an adjacent parked aircraft.", "FIG.", "2 is a perspective view of the passenger bridge of FIG.", "1 showing the multiple function solid state power converter connected to an electrically powered aircraft tug by means of an associated reel and cable assembly to charge the batteries of the tug.", "FIG.", "3A is a front view of the reel and cable assembly of FIG.", "2 showing the battery charging cable and associated connector in an extended and operational state.", "FIG.", "3B is a frontal view of the reel and cable assembly of FIG.", "2 with the power cable and connector in a stowed and inoperative state.", "FIG.", "4A is a cross-sectional view of reel and cable assembly of FIG.", "2 taken along lines 4A-4A of FIG.", "3A.", "FIG.", "4B is a cross-sectional view of the reel and cable assembly of FIG.", "2 taken along lines 4B-4B of FIG.", "3B.", "FIG.", "5A is a cross-sectional view of the reel and cable assembly of FIG.", "2 taken long lines 5A-5A of FIG.", "3A.", "FIG.", "5B is a cross-sectional view of the reel and cable assembly of FIG.", "2 taken along lines 5B-5B of FIG.", "3B.", "FIG.", "6 is a simplified schematic diagram of control and indicator circuitry contained within the reel and cable assembly of FIG.", "2.FIG.", "7 is a perspective view of a passenger boarding bridge incorporating an alternate embodiment of the dual purpose solid state power converter of the present disclosure wherein the battery charging output cable is suspended from a hanger mounted on the housing of the power converter when not in use.", "FIG.", "8 is a perspective view of the alternate embodiment of FIG.", "7 showing the battery charging cable connected to an adjacent electrically powered aircraft tug.", "FIG.", "9 is a simplified schematic diagram of control and indicator circuitry incorporated in the dual purpose power converter shown in FIGS.", "7 and 8.FIG.", "10 is a simplified functional block diagram of circuitry associated with the dual purpose power converter of FIGS.", "1 and 2 for inhibiting motion of the passenger boarding bridge when the power converter is being utilized to charge ground support equipment.", "FIG.", "11 a simplified functional block diagram of the dual purpose power converter of FIGS.", "1 and 2.FIG.", "12 is a simplified partial schematic and functional block diagram of the dual purpose power converter of FIGS.", "1 and 2.FIG.", "13 is an enlarged perspective view of a dual function power converter constructed in accordance with the disclosure mounted under the cab of a passenger boarding bridge.", "FIG.", "14 is an enlarged perspective view of a dual function power converter constructed in accordance with the disclosure mounted on a wheeled trailer for positioning by a tug.", "FIG.", "15 is a simplified schematic diagram of a dual function power converter constructed in accordance with the disclosure which provides DC ground power to a parked aircraft.", "DESCRIPTION OF THE PREFERRED EMBODIMENTS The following description of the preferred embodiments is merely exemplary in nature and is in no way intended to limit the disclosure, its application or use.", "Referring to the drawings, FIG.", "1 illustrates a passenger boarding bridge 10 of conventional design and construction for boarding an aircraft 12.The passenger boarding bridge 10 provides an enclosed, movable passageway which extends from an airport terminal gate (not shown) to a door 16 of the aircraft, allowing passengers to board and disembark the aircraft without being exposed to weather.", "The aircraft engaging end of the passenger boarding bridge is typically movable; moving up and down, swinging left and right, and extending toward and away from the aircraft.", "Movement of the bridge is accomplished by multiple electric motors which receive power through a power cable (not shown) extending along the bridge to the terminal.", "FIG.", "2 illustrates the passenger boarding bridge 10 of FIG.", "1 in a retracted position and incorporating a dual function solid state power converter 18 of the present disclosure mounted under the cab 14 of the bridge.", "A reel and cable assembly 20 mounted on the wheeled carriage of the bridge enables the power converter to be connected to a parked electrically powered aircraft tug 22 by means of a cable 24 and a cable end connector 26.The power converter 18 receives power from the terminal by means of a cable (not shown) extending along the passenger boarding bridge.", "The power converter supplies ground power to aircraft 12 by means of a power cable 27, and battery charging power to tug 22 by means of a power cable 24.To prevent the boarding bridge from moving while tug 22 is being charged, which could result in physical damage to tug 22 or power cable 24, sensors within reel and cable assembly 20 detect when power cable 24 is not stowed on the reel, and is therefore in use.", "Referring first to FIG.", "3A, a frontal perspective view of the housing 30 of reel and cable assembly 20 is shown with cable 24 unwound from a storage reel 32.In this condition, with power switch 34 in the on position, power available indicator 36 is illuminated and cable stowed indicator 38 is not illuminated.", "Furthermore, the power connector 26 in this condition is not seated within the recess 40 provided on the front panel of housing 30 for stowing the connector.", "In contrast, the frontal perspective view of FIG.", "3B shows the assembly 20 with power connector 26 in a stowed position in recess 40, secured by a clamp 44, and power cable 24 wrapped around storage reel 32.In this condition, indicator 36 is not illuminated, indicator 38 is illuminated, and movement of the passenger boarding bridge is enabled.", "The motion inhibiting function of reel and cable assembly 20 is further shown in FIGS.", "4A, 4B, 5A and 5B.", "Referring to FIG.", "4A, when power cable 24 is unwound from the reel 32, multiple spring-biased pressure switches 46a-46d are unactuated and electrically open.", "Moreover, as shown in FIG.", "5A, when connector 26 is not in recess 40, a spring-biased pressure switch 48 is unactuated and electrically open.", "If any one of switches 46 and 48 is in the open position, the power cable stowed indicator 38 is not illuminated and movement of the passenger bridge is inhibited.", "By contrast, as shown in FIG.", "4B, when power cable 24 is wound around reel 32, the spring-biased pressure switches 46a-46d are actuated to an electrically closed condition.", "Moreover, as shown in FIG.", "5B, when connector 26 is seated in recess 40 and locked in place by latch 44, spring-biased pressure switch 48 is actuated to an electrically closed condition.", "When all of the cable position sensing switches (46a, 46b, 46c, 46d and 48) are in their electrically closed condition, cable stowed indicator 38 illuminates and movement of passenger bridge 10 is enabled.", "Referring to FIG.", "6, pressure actuated switches 46a, 46b, 46c and 46d and 48 are electrically connected in series and through a cable 50 to the cab 14 of passenger boarding bridge 10 to prevent the positioning motors associated with the boarding bridge from being actuated when any of the five switches is not in an electrically closed condition.", "The cable stowed indicator 38 is powered from the boarding bridge control circuitry through cable 30 to indicate to ramp personnel that the passageway is enabled for movement.", "The power control switch 34 provided on the front panel 42 of housing 30 is connected through a cable 52 to the control circuit of the dual function solid state power converter 18 such that the availability of battery charging power on power cable 24 can be controlled by ramp personnel.", "The power available indicator 36 is also powered through cable 52 by the power converter to indicate that battery charging power is available.", "The battery charging power cable 24 is connected to power converter 18 through a separate cable 54.An alternative embodiment of the disclosure, wherein the battery charging cable 24 is suspended directly from power converter 18, is shown in FIGS.", "7-9.Referring to FIG.", "7, when in its stowed position, the battery charging power cable 24 is suspended from a hanger assembly 56 on the side of the housing of power converter 18.When battery charging cable 24 is in use and connected to the electrically powered tug 22, the cable is removed from hanger 56 as shown in FIG.", "8.Referring to FIG.", "9, hanger assembly 56 is mechanically coupled to a spring-biased pressure-actuated switch 58 such that when power cable 24 is hanging from the hanger assembly in a stowed condition, switch 58 is actuated to an electrically closed condition.", "Conversely, when power cable 24 is removed from hanger 58 for use, switch 58 reverts to an electrically open condition and movement of passenger bridge 10 is inhibited.", "A cable 60 provides connections between switch 58 and the passenger bridge control circuits, as well as connections to the cable stowed indicator 38.A cable 62 provides connections between the battery charging control switch 34 and power converter 18, as well as connections between power available indicator 36 and power converter 18.Another cable 64 may be provided to supply battery charging power to cable 24 from power converter 18.It will be appreciated that in practice the sensing, control and indicating circuitry shown in FIG.", "9 may be incorporated directly into the enclosure of power converter 18.Alternatively, a separate enclosure 66 mounted on the outside surface of the power converter enclosure can be provided as shown in FIG.", "9.As previously described, passenger boarding bridge 10 is positioned by means of electric motors such that it allows passengers to step from the end of the bridge into the door 16 of parked aircraft 12.Referring to FIG.", "10, the bridge positioning system is seen to comprise a first electric motor 70 for steering the cab 14 of the bridge left and right.", "A second electric motor 72 is provided for extending and retracting the bridge toward and away from the parked aircraft.", "A third electric motor 74 is provided to raise and lower the bridge to accommodate the height of the aircraft door.", "Together, motors 70, 72 and 74 allow the passenger boarding bridge 10 to accommodate a wide range of aircraft parked at the gate associated with the bridge.", "The three bridge positioning motors, 70, 72 and 74, are controlled by control circuits 76 in response to operator inputs entered by means of an operator control panel 78 in the cab 14 of the bridge 10.In addition, the bridge positioning system may include a position sensor 80 which provides an additional input to control circuits 76 such that small variations in the height of the aircraft are automatically accommodated by the bridge elevation motor 74.As previously described, and in accordance with one aspect of the disclosure, the function of control circuits 76 is inhibited when the battery charging function of the dual purpose solid state converter 18 is in use.", "In particular, when power cable 24 is removed from reel 32 to connect to tug 22 or other electrically powered ground service equipment, a switch is actuated as previously described to provide an inhibit signal to control circuits 76 which prevent the control circuits from supplying power to any of motors 70, 72 and 74, regardless of operator inputs on control panel 78.When the battery charging function is complete and the battery charging power cable 24 is restored to its storage condition on reel 32, or, in the case of the embodiment of FIGS.", "7-9, on hangar 56 to actuate switch 58, the inhibit signal is removed and control circuits 76 are again fully functional to allow positioning of passenger boarding bridge 10.Power available indicator 36 may be powered by control circuits 76 to indicate when the charging function is active and motion of the passenger boarding bridge is inhibited.", "In practice, the bridge positioning motors and associated control circuits are powered by a three phase AC power source which may, or may not, be the same power source that powers the dual purpose solid state power converter 18.Referring to FIG.", "11, the dual purpose solid state power converter 18 includes an input circuit 82 which receives three phase power from power distribution circuits in the airport terminal.", "This input circuit 82 converts the three phase AC signal to a DC signal on a bus 84 which is supplied to an aircraft power circuit 86 and to a battery charging circuit 88.The aircraft power circuit 82 converts the DC power from bus 84 to meet aircraft ground power requirements, in the present embodiment, a three phase 115-200 volt 400 hertz current which is supplied as ground power to a parked aircraft.", "A monitoring circuit 90 may be provided to monitor the current and voltage supplied to the aircraft and to cause a control circuit 92 to interrupt power to the aircraft should predetermined limits be exceeded.", "The battery charger circuit 88 converts the DC power on bus 84 to a lower voltage controlled DC current appropriate for charging batteries in ground service equipment.", "Typically, this voltage will be in the order of 28 volts DC and the current provided will be low, typically in the order of 20 amps or less, depending on battery condition.", "A monitoring circuit 94 monitors the output of battery charger circuit 88 to interrupt operation of the charger circuit in the event predetermined current or voltage limits are exceeded.", "Additionally, voltage and temperature monitoring circuits may be provided in association with the batteries under charge in the ground service equipment to adjust the charging voltage or the charging current as required.", "Control circuit 92 includes connections to a battery charging ramp control panel to signal when the battery charger is in use and to allow ramp personnel to control the charging function.", "Additional connections are provided for ramp personnel to control the application of ground power to the aircraft.", "Referring to FIG.", "12, the dual function power converter 18 may include a thyristor rectifier bridge circuit 100 and DC filter 102 of conventional design and construction which converts a three-phase AC supply current to a direct current on an internal bus 104.This direct current is applied to a three-phase inverter 106 of conventional design and construction which converts the DC to a 400 hertz three-phase 115/200-volt signal.", "This 400-hertz signal is filtered by a conventional filter circuit 108 and applied to the primary windings of a three-phase output transformer 110.The secondary windings of output transformer 110 are connected through a contactor 112 to cable 27 (not shown in FIG.", "12) which connects the power supply to the electrical system of a parked aircraft.", "In accordance with the disclosure, the DC current developed on bus 104 is simultaneously applied to a DC to DC converter 114 of conventional design and construction.", "The lower voltage DC output of this converter, typically 28 volts DC, is connected through a contactor 116 to battery charging current power cable 24 (not shown in FIG.", "12) for charging batteries in electrically-powered aircraft tugs or other electrically-powered ground service equipment.", "The ramp vehicle being thus charged may include a voltage sensor and a temperature sensor which provide signals to inputs 118 and 120, respectively, of the DC to DC converter circuit.", "These sensing signals are utilized by the converter circuit to maintain a charging current and voltage at the vehicle appropriate to the condition of the vehicle's battery.", "The dual function power converter 18 preferably further includes a control circuit 122 which functions to control the operation of thyristor rectifier 100, DC to AC inverter 106, and DC to DC converter 114 in response to control signals applied to the converter at inputs 124 and 126.Control circuit 122 further controls contactors 112 and 116, and provides an external indication at 128 that aircraft supply current is available and at 130 that battery charging current is available.", "Referring to FIG.", "13, dual function power converter 18 is preferably enclosed within an enclosure 132 which provides protection against the weather while providing the internal circuitry of the converter with adequate ventilation and heat dissipation.", "In the case of the converter being utilized in conjunction with a passenger boarding bridge, the converter may be advantageously mounted under the jetway with input power being provided to the converter by a cable extending the length of the bridge.", "The power output cables associated with the converter may be suspended from the bridge, or from the power converter enclosure, in the manner previously described.", "A control panel 134 may be provided on the exterior of the housing to provide for control and monitoring of the converter by ramp personnel.", "It will be appreciated that the power converter 18 can be alternatively mounted on a wheeled cart 136 and towed by a tug to an operating position, as shown in FIG.", "14.Or, the power converter can be installed in a stationary position, such as within an airport terminal, and connected to an aircraft and electrically powered ground support equipment by a power cable of appropriate length.", "It will be further appreciated that the dual function power converter of the disclosure can be provided as a converter 140 to supply parked aircraft with DC power instead of AC ground power.", "In this case, as shown in FIG.", "15, the three phase inverter 106 is replaced by a DC to DC converter 142 which converts DC current available on DC bus 104 to a lower voltage DC current, typically 28 volts DC.", "This lower voltage DC current is supplied through contactor 112 to power cable 27 for application to a parked aircraft.", "In this case, output filter 108 and output transformer 110 are not required.", "The DC to DC converter 114 provided for the battery charging function remains unchanged.", "In all other respects, dual function solid state converter 140 is identical to power converter 18, and may be utilized on a passenger boarding bridge, on a wheeled cart, or a stationary installation.", "The foregoing detailed description has been given for clearness of understanding only and no unnecessary limitations should be understood therefrom.", "Accordingly, while one or more particular embodiments of the disclosure have been shown and described, it will be apparent to those skilled in the art that changes and modifications may be made therein without departing from the invention if its broader aspects, and, therefore, the aim in the appended claims is to cover all such changes and modifications as fall within the true spirit and scope of the present disclosure." ] ]
Patent_15874242
[ [ "VIDEO FRAME PROCESSING METHOD", "A video frame processing method, which comprises: (a) capturing at least one first video flame via a first camera; (b) capturing at least one second video frame via a second camera; and (c) adjusting one candidate second video frame of the second video frames based on one of the first video frame to generate a target single view video frame." ], [ "1.A video frame processing method, comprising: (a) capturing at least one first video frame via a first camera utilizing a first camera parameter; (b) capturing at least one second video frame via a second camera utilizing a second camera parameter, wherein the second camera parameter is different from the first camera parameter; and (c) generating a target single view video frame corresponding to a specific time point according to the at least one first video frame, the first camera parameter and the second camera parameter.", "2.The video frame processing method of claim 1, wherein the step (c) comprises: determining if the first video frame corresponding to the specific time point exists; if yes, selecting the first video frame as the target single view video frame; and if not, interpolating the target single view video frame according to one of the second video frames corresponding to the specific time point and one or more adjacent frames captured by the first camera and/or the second camera.", "3.The video frame processing method of claim 2, wherein the first camera parameter and the second camera parameter are video frame resolutions, wherein the first camera parameter is higher than the second camera parameter, and a video frame rate of the first camera is identical to or lower than a video frame rate of the second camera.", "4.The video frame processing method of claim 2, wherein the first camera parameter and the second camera parameter are video frame rates, wherein the first camera has a video frame rate lower than which of the first cameras.", "5.The video frame processing method of claim 1, wherein the step (c) generates the target single view video frame further according to one of the second video frames.", "6.The video frame processing method of claim 5, wherein the step (c) interpolates the target single view video frame from the first video frame corresponding to the specific time point and the one of the second video frames.", "7.The video frame processing method of claim 5, wherein the first camera parameter and the second camera parameter are video frame capturing parameters, and the step (c) generates the target single view video frame according to, video &aim capturing parameters for the first video frame corresponding to the specific time point and the one of the second video frames.", "8.The video frame processing method of claim 7, wherein the frame capturing parameter comprises at least one of: capturing time, exposure time, depth of field, focus, ISO speed, and white balance.", "9.The video frame processing method of claim 1, wherein the step (c) generates the target single view video frame further according to at least one adjacent frames captured by the first camera and or the second camera.", "10.The video frame processing method of claim 1, wherein the first camera parameter and the second camera parameter are video frame rates, wherein the first camera has a video frame rate higher than which of the second camera.", "11.The video frame processing method of claim 10, wherein the target single view video frame has an image resolution higher than which of the first video frame.", "12.The video frame processing method of claim 1, wherein the first camera parameter and the second camera parameter are a exposure time and/or an ISO speed, wherein the step (c) comprises: determining at least one region to be enhanced in the first video frame corresponding to the specific time point according to the first camera parameter; determining at least one region to be referenced in the second video frame corresponding to the specific time point according to the second camera parameter; and enhancing the at least one region to be enhanced in the first video frame based on the at least one region to be referenced in the second video frame.", "13.The video frame processing method of claim 1, wherein the target single view video frame further corresponds to a viewing perspective of the first video frame, wherein generating the target video frame comprising: selecting the first video frame as the target single view video frame when image quality of the first video frame is better than a quality threshold; and generating the target single view video frame by adjusting the first video frame or the second video frame when the image quality of the first video frame is not better than the quality threshold, including: interpolating the first video frame and another video frame captured via the first camera to generate a third video frame, and adjusting the second video frame based the third frame to generate the target single view video frame." ], [ "<SOH> BACKGROUND <EOH>Conventionally, a camera captures a frame via a camera parameter.", "The camera parameter can have, for example, a frame capturing parameter such as an exposure time or a frame rate.", "Exposure time (or named shutter speed) is the effective length of time a camera's shutter is open.", "Exposure time along with the aperture of the lens (also called f-number) determines the amount of light that reaches the film or an image sensor inside the camera.", "Long exposure time will cause image blur easily.", "On the contrary, short exposure time will cause in dark or noise easily.", "The aperture or camera sensor is always small in a camera phone (or a smartphone).", "When captured video frame resolution increases, the amount of light of each pixel will decrease.", "Therefore, h is hard to set a balanced camera parameter to generate a fine video frame.", "A stereo camera is a type of camera with two or more cameras with a separate image sensor for each camera.", "A stereo camera is always used to generate a multi-view video frame (ex, a 3D video frame) based on the video frames generated from different cameras.", "Also, different camera parameters can be applied to different cameras.", "An electronic device with a stereo camera becomes more popular in recent years (ex.", "a smart phone with a stereo camera), since the user may hope he can capture a stereo image at any time he wants." ], [ "<SOH> SUMMARY <EOH>Therefore, one objective of the present application is to provide a video frame processing method to generate a target single view video frame from the video frames captured by a stereo camera.", "One embodiment of the present application discloses a video frame processing method, which comprises: (a) capturing at least one first video frame via a first camera; (b)capturing at least one second video frame via a second camera; and (c) adjusting one candidate second video frame of the second video frames based on one of the first video frame to generate a target single view video frame.", "Another embodiment of the present application discloses: a video frame processing method, which comprises: (a)capturing at least one first video frame via a first camera utilizing a first camera parameter; (b) capturing at least one second video frame via a second camera utilizing a second camera parameter, wherein the second camera parameter is different from the first camera parameter; and (c) generating a target single view video frame corresponding to a specific time point according to the at least one first video frame, the first camera parameter and the second camera parameter.", "In view of above-mentioned embodiments, the target single view video frames can be generated from video frames with different camera parameters.", "Therefore a better target single view video frame can be acquired.", "These and other objectives of the present invention will no doubt become obvious to those of ordinary skill in the art after reading the following detailed description of the preferred embodiment that is illustrated in the various figures and drawings." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. Ser.", "No.", "14/221,260, filed Mar.", "20, 2014, which is incorporated herein by reference.", "U.S. Ser.", "No.", "14/221,260 claims the benefit of priority under 119(e) of U.S.", "Provisional Application No.", "61/803,881, filed Mar.", "21, 2013, which is incorporated herein by reference.", "BACKGROUND Conventionally, a camera captures a frame via a camera parameter.", "The camera parameter can have, for example, a frame capturing parameter such as an exposure time or a frame rate.", "Exposure time (or named shutter speed) is the effective length of time a camera's shutter is open.", "Exposure time along with the aperture of the lens (also called f-number) determines the amount of light that reaches the film or an image sensor inside the camera.", "Long exposure time will cause image blur easily.", "On the contrary, short exposure time will cause in dark or noise easily.", "The aperture or camera sensor is always small in a camera phone (or a smartphone).", "When captured video frame resolution increases, the amount of light of each pixel will decrease.", "Therefore, h is hard to set a balanced camera parameter to generate a fine video frame.", "A stereo camera is a type of camera with two or more cameras with a separate image sensor for each camera.", "A stereo camera is always used to generate a multi-view video frame (ex, a 3D video frame) based on the video frames generated from different cameras.", "Also, different camera parameters can be applied to different cameras.", "An electronic device with a stereo camera becomes more popular in recent years (ex.", "a smart phone with a stereo camera), since the user may hope he can capture a stereo image at any time he wants.", "SUMMARY Therefore, one objective of the present application is to provide a video frame processing method to generate a target single view video frame from the video frames captured by a stereo camera.", "One embodiment of the present application discloses a video frame processing method, which comprises: (a) capturing at least one first video frame via a first camera; (b)capturing at least one second video frame via a second camera; and (c) adjusting one candidate second video frame of the second video frames based on one of the first video frame to generate a target single view video frame.", "Another embodiment of the present application discloses: a video frame processing method, which comprises: (a)capturing at least one first video frame via a first camera utilizing a first camera parameter; (b) capturing at least one second video frame via a second camera utilizing a second camera parameter, wherein the second camera parameter is different from the first camera parameter; and (c) generating a target single view video frame corresponding to a specific time point according to the at least one first video frame, the first camera parameter and the second camera parameter.", "In view of above-mentioned embodiments, the target single view video frames can be generated from video frames with different camera parameters.", "Therefore a better target single view video frame can be acquired.", "These and other objectives of the present invention will no doubt become obvious to those of ordinary skill in the art after reading the following detailed description of the preferred embodiment that is illustrated in the various figures and drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a schematic diagram illustrating a video processing method according to one embodiment of the present application.", "FIG.", "2 is a flow chart illustrating the steps for the video processing method illustrated in FIG.", "1, according to one embodiment of the present application.", "FIG.", "3 is a flow chart illustrating the steps for the video processing method illustrated in FIG.", "1, according to another embodiment of the present application.", "FIG.", "4 is a schematic diagram illustrating a video processing method according to one embodiment of the present application.", "FIG.", "5 is a flow chart illustrating the steps for the video processing method illustrated in FIG.", "4, according to one embodiment of the present application.", "FIG.", "6 is a schematic diagram illustrating a video processing method according to another embodiment of the present application.", "FIG.", "7 is a flow chart illustrating the steps for the video processing method illustrated in FIG.", "6, according to one embodiment of the present application.", "FIG.", "8 is a flow chart illustrating the steps for the video processing method illustrate (in FIG.", "6 according to another embodiment of the present application.", "FIG.", "9 is a schematic diagram illustrating a video processing method according to another embodiment of the present application.", "FIG.", "10 is a flow chart illustrating the steps for the video processing method illustrated in FIG.", "9, according to one embodiment of the present application.", "FIG.", "11 is a flow chart illustrating the steps for the video processing method illustrated FIG.", "9, according to another embodiment of the present application.", "FIG.", "12 and FIG.", "13 are schematic diagrams illustrating a video processing method according to another embodiment of the present application.", "DETAILED DESCRIPTION In the following embodiment, two cameras are taken for example to explain the concept of the present application.", "However, please note more than two cameras can be applied to this application.", "FIG.", "1 is a schematic diagram illustrating a video processing method according to one embodiment of the present application.", "As shown in FIG.", "1, one or more first video frames FF_1, FF 2 .", ".", ".", "FF 5 are captured by a first camera, and one or more second video frames SF_1, SF_2 .", ".", ".", "SF_5 are captured by a second camera.", "In one embodiment, the first camera captures each first video frame from the perspective of the left eye, the second camera, captures each second video frame from the perspective of the right eye, but is not limited.", "For example, the first camera and the second camera may be two independent cameras comprise independent, buttons and batteries.", "However, the first camera and the second camera are not limited to physically independent cameras.", "In one embodiment, the first camera and the second camera can be provided on a single electronic device, for example, two lenses on a single electronic device such as a camera or a mobile phone, using a single image sensor or independent image sensors.", "The video processing method of the present application is, for example, performed by the processing unit of the single electronic device.", "The target single view video frames TSF_1, TSF 2.TSF_5 are, for example, the video frames to be output to a display for displaying, but not limited.", "Such target single view video frame can be generated based on only the first video frame, or both the first video frame and the second video flame, which will be described later, FIG.", "2 is a flow chart illustrating the steps for the video processing method illustrated in FIG 1, according to one embodiment of the present application.", "As shown in FIG.", "2, the video processing method comprises: Step 201 Capture first video frames and second video frames by the first camera and the second camera, respectively.", "Step 203 Analyze the video quality for one of the first video frames and the video quality for one of the second video frames corresponding to the analyzed first video frame.", "For example, analyze the video quality for the first video frame FF 2 and the second video frame SF 2.A first video frame and a second video frame which are corresponding to each other are, for example, frames captured at the same or similar time point by the first and the second cameras, respectively.", "However, the present application is not limited thereto.", "Many methods can be applied to analyze the video quality.", "For example, the blur level/the sharpness level of each entire video frame and/or the region of interest (e.g., one or combination of the face region, the center region, and the auto-focus region) in each video frame can be computed to analyze the video quality.", "Also, the video frame;can be compared to a reference video frame to analyze the video, quality.", "Besides, at least one of the following parameters of each entire video frame and/or the region of interest can be computed to analyze the video quality: noise, edge, dynamic range, blocking artifact, mean intensity, color temperature, scene composition, people face and/or animal presence, image content that attracts more or less interest, and Spatial I temporal I Frequency masking.", "Step 205 Determine if the video quality of the first video frame is better than a quality threshold.", "If yes, it means the video quality is good, go to step 207, if not, it means the video quality is bad, go to step 209.Step 207 Select the first video frame analyzed in the step 203 as the target single view video frame.", "For example, the first video frame FF 1 is determined to have a video quality better than the quality threshold, therefore the first video frame FF 1 is selected as the target single view video frame TSF 1.Step 209 Determine if the video quality of the second video frame is better than the quality threshold.", "If yes, go to step 213, if not go to step 211.Step 211 Interpolate the target single view video frame from the first video frame and the second video frame analyzed in the step 203.For example, both the first video frame FF 5 and the second video frame SF 5 are determined to have a video quality lower than the quality threshold, therefore the target single view video frame TSF 5 is interpolated from the first video frame FE 5 and the second video frame SF 5.Step 213 Select the second video frame analyzed in the step 203 and warp it.", "For example, the first video frame FF 3 is determined to have a video quality lower than the quality threshold and the second video frame SF 3 is determined to have a video quality better than the quality threshold.", "Therefore, the second video frame SL_3 is warped based on the first video frame FF_3 to generate a warped second video frame.", "To be specific, the warp operation performed on the second video frame is to eliminate the difference between the second video frame and the corresponding first video frame due to the diligent viewing perspectives.", "For the convenience for understanding, the second video frame can be named as a candidate second frame if the second video frame corresponds to the first video frame analyzed in the step 203.For example, if the first video frame FF_4 is analyzed in the step 203, the second video frame SF_4 is named a candidate second video frame, and the first video frame FF 4 is named a candidate first video frame.", "Please note, in one embodiment, the step 203 only analyzes the first video frame.", "In such embodiment, the steps 209, 211 can be removed, such that the step 205 can go to the step 213 if the result of the step 205 is no.", "Step 215 Select the adjustment result generated in the step 213 as the target single view video frame.", "For example, in FIG.", "1, the target single view video frame TSF_3 is generated by warping the second video frame SF 3 based on the first video frame FF 3.The step 213 can be replaced by other steps.", "In one embodiment, the second video frame is warped, and the target single view video frame is generated via synthesizing the warped second video frame and the first video frame corresponding to the warped second video frame.", "For example, in FIG.", "1, the target single view video frame TSF_4 may be generated by warping the second video frame SF_4 based on the first video frame FF_4 firstly, and then synthesizing the, warped second video frame and the first video frame FF 4.In another embodiment, the target single view video frame is generated via interpolating the first video frame and the second video frame.", "For example, in FIG.", "1, the target single view video frame TSF_4 may be a new video frame which is interpolating from the first video frame FF 4 and the second video frame SF 4.Alternatively, the steps 213, 215 can be replaced by: enhancing the first video image based on the second video frame to generate the target single view video frame if the video quality of the first video frame is bad and the video quality of the second video frame is good.", "For example, if the first video frame FF 4 has a bad video quality and the second video frame SF_4 has a good video quality, the first video frame FF 4 is enhanced based on the second video frame SF 4 to generate the target single view video frame TSF_4.Furthermore, the step 211 can be replaced by other steps.", "In one embodiment, the first video frame analyzed in the step 203 is selected as the target single view video frame, since both video qualities of the first and the second video frames analyzed in the step 203 are worse than the quality threshold.", "Alternatively, one of the first and the second video frames analyzed in the step 203 having a better video quality will be selected as the target single view video frame.", "That is, either the first video frame or the second video frame can be selected as the target single view video if both the first video frame or the second video have video qualities worse than the quality threshold, In the embodiment of FIG.", "1, the frame rates of the first camera and the second camera are the same, and corresponding first video frames and second video frames are simultaneously generated (ex, are simultaneously generated, and FF_2/SF_2 are simultaneously generated).", "However, it does not mean to limit the scope of the present application, the two cameras may have different frame rates and the corresponding first video frames and second video frames can be generated at different time points.", "Furthermore, the corresponding first video frames and second video frames may be generated at different time points even the two cameras have the same frame rates.", "For example, the capture of the first video frames and the second video frames is staggered in time, but with an identical frame rate.", "Additionally, the time intervals between the video frames can be different.", "Additionally, in one embodiment the video quality analyzing and determining steps are removed from the flow chart in FIG.", "2, as shown in FIG.", "3.In such embodiment, one candidate second video frame (the second video frame corresponding to the analyzed first video frame, as above-mentioned description) is adjusted based on the first video frame to generate the target single view video frame.", "As shown in steps 313, 315 in FIG.", "3, the target single view video frame is the warped candidate second video frame.", "Alternatively, the target single view video frame may be generated by synthesizing the warped second video frame and the corresponding first video frame.", "FIG.", "4 is a schematic diagram illustrating a video processing method according to one embodiment of the present application.", "As shown in FIG.", "4, the first video frames FF_1, FF_2, FF_3 and the second video frames SF_1, SF 2 are interleavingly captured by the first camera and the second camera, respectively.", "The first camera and the second camera are, for example, reside in a single electronic device.", "In one embodiment, the video frame rate for outputting the target single view video frames to the display is higher than which of the first camera and the second camera.", "In the embodiment of FIG.", "4, the target single view video frames can be generated via following methods: select the first video frame or the second video frame as the target single view video frame without modification (ex.", "FF_1 and TSF_1); warp or interpolate the second video frame as the target single view video frame according to the first video frame prior to or after the second video frame (ex, warp SF_1 according to FF_1 and FF_2); warp the first video frame and the second video frame to the same view to generate the target single view video frame (ex.", "SF_2 and FF_3 are warped to respectively generate TSF_4 and TSF_5); warp or interpolate the first video frame as the target single view video frame according to the second video frame prior to or after the first video frame, and warp or interpolate the second video frame as the target single view video frame according to the first video frame prior to or after the second video frame.", "Please note warp or interpolate described in this application indicates at least one the warp operation and the interpolating operation is performed.", "Please note the video quality analyzing and determining steps can be applied to the embodiment illustrated its FIG.", "4, to determine which method for generating the target single vide video frame should be applied.", "FIG.", "5 is a flow charting the steps for the video processing method illustrated in FIG.", "4, according to one embodiment present application.", "FIG.", "5 comprises the following steps: Step 501 Capture first video frames and second video frames by the camera and the second camera, respectively.", "Step 503 Determine if the video frame captured at a specific time point by a major camera exists.", "In this embodiment, the first camera is set as the major camera.", "In another embodiment, however, the second camera is set as the major camera.", "If yes, go to step 505, if not, go to step 507.Step 505 Select the video frame from the major camera as the target single view video frame.", "For example, assuming that the specific time point is time points T_1, T_3, or T_5, the first video frames FF_1, FF_2 and FF_3 exist, thus the first video frames FF_1, FF_2 and FF_3 are selected as the target single it video frames TSF_1, TSF_3 and TSF_5, without modification.", "In one embodiment, some modifications can be applied to the first video frames FF_1, FF_2 and FF_3.For example, the process of brightness adjustment and/or sharpness enhancement can be performed to the first video frames FF_1, FF_2 and FF_3, and then the modified first video frames are selected as the target single view video frames.", "Step 507 Select a video frame captured by a camera different from the major camera (e.g., the second camera).", "For example, assuming that the specific time point is time points T_2 or T_4, the first video frames do not exist, thus the second video frames SF 1, SF 2 are selected.", "Step 509 Adjust the video frame selected in the step 507 based on one or ore video frames from the major camera captured prior to or after the video frame selected in the step 507.For examples, assuming that one of the second video frames is selected in the step 507, the selected second video frame is warped and/or interpolated according to one or more first video frames prior to or after the selected second frame.", "Please note the interpolate operation in this application is not limited to a video frame directly adjacent to the selected video frame.", "For example, an interpolated video frame corresponding to the time point T_4 may be generated based on the second video frame SF 2 and at least one of the first video frames FF_2 and FF_3.Alternatively, the interpolated video frame corresponding to the time point T_4 may be generated based on the second video frame SF 2 and the first video frame FF 1.Step 511 Select the adjustment result generated in the step 509 as the target single view video frame.", "In this embodiment, the second video frame which is warped and/or interpolated is selected as the target single view video frame.", "In another embodiment, the step 509 in FIG.", "5 can be removed, and the target single view video frame is the second video frame selected in the step 507.For example, at the time points T_2 and T_4, the second video frames SF 1 and SF 2 are selected to be the target single view video frames TSF_2 and TSF_4, without modification.", "Alternatively, the brightness, sharpness and/or other attributes of the second video frames SF_1 and SF_2 may he adjusted before being selected as the target single view video frames TSF_2 and TSF_4.In yet another embodiment, the step 505 in FIG.", "5 can be replaced by other steps.", "For example, the first video frame corresponding to the specific time point is warped and/or interpolated according to one or more second video frames prior to or after, the first video frame, then selected as the target single view video frame for output.", "In still another embodiment, all of the first video frames and the second video frames arc warped to the same specific view, and then selected as the target single view video frames for output.", "For example, in FIG.", "4, the first video frames FF 1 to FF 3 and the second video frames SF_1 and SF_2 are outputted interleavingly after being warped to the same viewing direction.", "In the embodiment of FIG.", "4 the first camera and the second camera have the same video frame rate, and the interval between the first video frames or the second video frames are the same.", "However, the first camera and the second camera may have different video frame rates, and the interval between the first video frames or the second video frames may be different either.", "The embodiments of FIG.", "1 and FIG.", "4 can further comprise: interpolating at least two of the first video flames to generate a new first video frame, and adjusts the candidate second video frame based the new first video frame to generate the target single view video frame.", "Take the second video frame SF_2 in FIG.", "1 for example, if no first video frame FF_2 in FIG.", "1 exists or the quality of first video frame FF_2 is too bad, which is simultaneously captured, a new first video frame is generated based on the first video frames FF 1 and FF_3, and the second video frame SF 2 is adjusted according to the new first video frame.", "The above-mentioned embodiments can he summarized as: A video frame processing method, comprising: (a) capturing at least one first video frame via a first camera; (b) capturing at least one second video frame via a second camera, (c) adjusting one candidate second video frame of the second video frames based on one of the first video frame to generate a target single view video frame.", "FIG.", "6 is a schematic diagram illustrating a video processing method according to another embodiment of the present application.", "In the following embodiments, an A camera and a B camera are provided to respectively capture A video frames and B video frames.", "In FIG.", "6, the A video frames are denoted as AF_1 to AF_3, and so on.", "And, the B video frames are denoted as BF_1 to BF 5, and so on.", "The A video frames and the B video frames are captured via different camera parameters.", "For example, the A camera has frame rate lower than which of the B camera, and the A video frames have video frame resolutions higher than which of the B video frames, as illustrated in FIG.", "6.In one embodiment, the A video frames are in a Full HD format and captured at a frame rate of 15 fps, while the B video frames are in a VGA format and captured at a frame rate of 30 fps.", "The video processing method can be applied to generate and output the target single view video frames in the full HD format at a frame rate of 30 fps.", "That is, a video frame resolution of the target single view video frame is the same as the first video frame, and a frame rate of the target single view video frame is the same as the second video frame.", "In one embodiment, one of the two cameras which can provide the highest video frame resolution will be selected as a major camera (e.g., the A camera), and the target single view video frames can be generated via following method interleavingly selecting an A video frame without modification and an interpolated B video image as the target single view video frame.", "In FIG.", "6, the interpolated B video images are denoted as BFM_1 to BFM_5 and so on.", "In this embodiment, the selection of the A video frame and the interpolated B video image is staggered in time.", "Each interpolated B video image is synthesized according to the B video frame and at least one of the adjacent frames captured by the A camera and/or the B camera.", "For example, the interpolated B video frame BFM 2 is synthesized according to the second video frame BF 2 and at least one of the A video frames AF 1 and AF_2, and the B video frames BF_1 and BF_3.In one embodiment, each interpolated B video frame being synthesized has the same video frame resolution as which of the A video frame.", "By this way, the frame rate of the target single view video frame is larger than which of the first video frames, and the video frame resolution of the target single view video frame is larger than which of the second video frames.", "FIG.", "7 is a flow chart illustrating the steps for the video processing method illustrated in FIG.", "6, according to one embodiment of the present application.", "The flow chart in FIG.", "7 comprises the following steps: Step 701 Capture A video frames and B video frames by the A camera and the B camera, respectively.", "Step 703 Set the camera with a largest video frame resolution as the major camera.", "For example, in the embodiment of FIG.", "6, the A camera, is set as the major camera.", "Step 705 Determine if the video frame captured at a specific time point by the major camera exists.", "If yes, go to step 707, if not, go to step 709.Step 707 Select the video frame from the major camera as the target single view video frame.", "For example, at time points T_1 and T_3, the A video frames AF_1 and AF_2 exist, thus the A video frames AF 1 and AF_2 are selected as the target single view video frames.", "In one embodiment, the A video frames AF_1 and AF_2 can be directly selected as the target single view video frames.", "However, in another embodiment, some modification (ex,sharpness enhancement or brightness adjustment) can be performed to the A video frames first, and then the modified.", "A video frames can be selected as the target single view video frames.", "Step 709 Interpolate a new video frame from the video frame captured at the specific time point by the camera different from the major camera and at least one of the adjacent video frames captured by the A camera and/or the B camera.", "It is assumed that the.", "A camera is the major camera, then a new video frame is interpolated from the B video frame captured at the specific time point and at least one of the adjacent video frames captured by the A camera and/or the B camera, wherein the adjacent video frames are the video frames captured at or near the specific time point.", "Taking the time point T_2 as an example, the adjacent video frames may he one or a combination of the A video frames AF 1 and AF_2, and the B video frames BF 1 and BF 3.Step 711 Select the interpolated video frame as the target single view video frame.", "For example, at the time point T_2, no A video frame exist, thus the target single view video frame is generated from interpolating the B video frame BF_2, and at least one of B video frames BF_1, BF_3, and A video frames AF_1, AF 2.In another embodiment, one of the two cameras which can support the highest video frame rate will be selected as a major camera (e.g., the B camera), and the target single view video frames in FIG.", "6 can be further generated via following method: selecting each, interpolated B video frame as the target single view video frame.", "The interpolated B video image is synthesized according to the corresponding B video frame and at least one of the A video frames captured at or near the time at which the B video frame being captured.", "For example, the interpolated B video frame BFM 1 is synthesized according to the B video frame BF 1 and the A video frames AF 1.In another example, the interpolated B video frame BFM_2 is synthesized according to the B video frame BF 2 and at least one, of the A video frames AF_1, AF 2.In another embodiment, the interpolated B video image is generated according to the corresponding B video frame and at least one adjacent frames captured by the A camera and/or the B camera.", "By this way, the video frame rate of the target single view video frame is the same as which of the A video flames, and the video frame resolution of the target single view video frame is larger than which of the B video frames.", "FIG.", "8 is a flow chart illustrating the steps for the video processing;method illustrated in FIG.", "6, according to another embodiment of the present application.", "The flow chart in FIG.", "8 comprises the following steps: Step 801 Capture A video frames and B video frames by the A camera and the B camera, respectively.", "Step 803 Set the camera with a largest frame rate as the major camera.", "For example, in the embodiment of FIG.", "6 the B camera is set as the major camera.", "Step 805 For each video frame captured by the major camera, interpolate a new video frame from the video frame captured by the major camera and at least one of the corresponding video frames captured by the camera different from the major camera and the adjacent video frames captured by the major camera.", "It is assumed that the B camera is the major camera, then for each B video frame, interpolate a new video frame from the B video frame and at least one of: the corresponding A video frames and the adjacent B video frames.", "In which, the corresponding A video frames are video frames captured at or near (e.g., prior to or after) a time point that the B video frame is captured, and the adjacent B video frames are video frames captured prior to or after the B video frame.", "Taking the B video frame BF 3 in FIG.", "6 as an example, the corresponding A video frames may be the A video frame AF_2, and the adjacent B video frames may be the B video frames BF 2 and The new video frame (i.e., the interpolated B video frame BFM_3) is interpolated from the B video frame BF_3 and at least one of the A video frame AF 2 and the B video frames BF 2 and BF 4.The video frame resolution of the interpolated video frame is larger than which of the B video frame.", "For example, each of the interpolated B video frames BFM_1 to BFM_5 has video frame resolution the same as which of the A video frames AF 1 to AF_3, as shown in FIG.", "6.Step 807 Select the interpolated video frame as the target single view video frame.", "For example, in FIG.", "6, the interpolated B video frames BFM 1 to BFM 5 are selected as the target single view video frames TSF 1 to TSF 5.FIG.", "9 is a schematic diagram illustrating a video processing method according to another embodiment of the present application.", "The embodiment of FIG.", "9 is similar with the embodiment of FIG.", "6, one different between the embodiments of FIG.", "6 and FIG.", "9 is that the A video frames and B video frames have different frame capturing parameters in FIG.", "9 rather the video frame resolutions in FIG.", "6.The frame capturing parameters can comprises at least one of capturing time, exposure time, depth of field, focus, ISO speed, and white balance.", "FIG.", "10 is a flow chart illustrating the steps for the video processing method illustrated in FIG.", "9/ according to one embodiment of the present application.", "The flow chart in FIG.", "10 comprises: Step 1001 Capture A video frames and B video frames by the A camera and the B camera respectively.", "Step 1003 Set the camera with a lowest video frame rate as the major camera.", "For example 1 in the embodiment of FIG.", "9 1 the A camera is set as the major camera.", "Step 1005 Determine if the video frame captured at a specific time point by the major camera exists.", "If yes 1 go to step 1007, if not, go to step 1009.Step 1007 Select the video frame from the major camera as the target single view video frame.", "For example 1 at time points T_1 and T_3 1 the A video frames AF_1 and AF_2 exist 1 thus the A video frames AF 1 and AF_2 are selected as the target single view video frames 1 with or without modification as illustrated in the embodiment of FIG.", "7.Step 1009 Interpolate a new video frame from the video frame captured at the specific time point by the camera different from the major camera and at least one of the adjacent video frames captured by the A camera and/or the B camera.", "It is assumed that the A camera is the major camera 1 then a new video frame is interpolated from the B video frame captured at the specific time point and at least one of the adjacent video frames captured by the A camera and/or the B camera 1 wherein the adjacent video frames are the video frames captured at or near the specific time point.", "Taking the time point T_2 as an example 1 the adjacent video frames may be one or a combination of the A video frames AF 1 and AF_2, and the B video frames BF 1 and BF 3.Step 1011 Select the interpolated video frame as the target single view video frame.", "For example, at the time points T_2, no A video frame exist, thus the target single view video frame is generated from interpolating the B video frame BF_2, and at least one of B video frames BF_1, BF_3, A video frames AF_1, AF 2.FIG.", "11 is a flow chart illustrating the steps for the video processing method illustrated in FIG.", "9, according to another embodiment of the present application.", "The flow chart in FIG.", "11 comprises the following steps: Step 1101 Capture A video frames and B video frames by the A camera and the B camera, respectively.", "Step 1103 Set the camera with a largest frame rate as the major camera.", "For example, in the embodiment of FIG.", "9, the B camera is set as the major camera.", "Step 1105 For each video frame captured by the major camera, interpolate a new video frame from the video frame captured by the major camera and at least one of the corresponding video frames captured by the camera different from the major camera and the adjacent video frames captured by the major camera.", "It is assumed that the B camera is the major camera, then for each B video frame, interpolate a new video frame from the B video frame and at least one of the corresponding A video frames and the adjacent B video frames.", "In which, the corresponding A video frames are video frames captured at or near (e.g., prior to or after) a time point that the B video frame is captured, and the adjacent B video frames are, video frames captured prior to or after the B video frame.", "Taking the B video frame BF 3 in FIG.", "9 as an example, the corresponding A video frames ma be the A video frame AF_2, and the adjacent B video frames may the second video frames BF 2 and BF_4.The new video frame is interpolated from the B video frame BF 3 and at least one of the A video frame AF 2 and the B video frames BF 2 and BF 4.Step 110 Select the interpolated video frame as the target single view video frame.", "In this embodiment, the video frame rate of the target single view video frames is the same as the B video frames.", "Furthermore, the video quality can be enhanced by synthesizing the B video frames with the A video frames.", "For example, when the brightness for some dark regions of the B video frame is too low, it may be compensated based on corresponding region of the A video frame.", "Please note the A video frames and the B video frames of the embodiments in FIG.", "6 and FIG.", "9 can be interleavingly captured, as the embodiment of FIG.", "4.In this embodiment, the video frame rate of the first camera is identical to the video frame rate of the second camera.", "It would be appreciated that the brightness of the video frame is affected by factors such as the exposure time and/or the ISO speed.", "In another embodiment of the present application, the camera parameter of the A camera and the camera parameter of the B camera are the exposure time and/or the ISO speed, and are set differently.", "In this embodiment, assuming that the A camera is selected as the major camera, then the A video frame can be compensated by the corresponding B video frame.", "To be specific, for the A video frame corresponding to each specific time point, at least one region to be enhanced in the A video frame is determined according to the camera parameter of the A camera, and at least one region to be referenced in the B video frame, corresponding to the specific time point is determined according to the camera parameter of the B camera.", "Accordingly, the at least one region to be enhanced in the A video frame can be enhanced based on the at least one region to be referenced in the B video frame.", "For example, assuming that some region in the A video image is overexposed while the brightness of the other region is fine due to the camera parameter of the A camera, and some region in the B video image is over dark while the brightness of the other region is fine due to the camera parameter of the B camera.", "The overexposed region (i.e., the region to be enhanced) in the A video image can be enhanced by the bright parts (i.e., the region to be referenced) in the corresponding B video image.", "For another example, assuming that some region in the A video image is over dark while the brightness of the other region is fine due to the camera parameter of the A camera, and some region in the B video image is overexposed while the brightness of the other region is fine due to the camera parameter of the B camera.", "The over-dark region (i.e., the region to be enhanced) in the A video image can be enhanced by the dark parts (i.e., the region to be referenced) in the corresponding B video image.", "FIG.", "12 is another embodiment of the present application.", "In the embodiment of FIG.", "12, the A video frames and the B video frames are captured via the same video frame rates, but the A video frames have brightness higher than which of the B video frames.", "In such embodiment, the video frame(s) of one camera can be enhanced by the video frame(s) of the other camera.", "For example, assuming that the A camera is selected as the major camera.", "If the A video frame AF 1 is too bright, it can be enhanced based on the B video frame BF 1 to generate a target single view video frame TSF_1, since the B video frame BF_1 has lower brightness.", "In such case the B video frame BF_1 is regarded as the enhancing standard video frame, and the A video frame AF_1 is regarded as a video frame corresponding to the enhancing standard video frame.", "On the contrary, if the B video frame BF_2 is too dark, it can be enhanced and warped based on the A video frame AF 2 to generate a target single view video frame TSF_2, since the A video frame AF 2 has higher brightness.", "In such case the A video frame AF 2 is regarded as the enhancing standard video frame.", "Please note the enhancing here, is not limited to mean enhancing the whole video frame based on another whole video frame.", "The enhancing here can mean enhancing a region of interest for one video frame based on a corresponding region of another video frame.", "For example, if a people face in the A video frame AF_3 is too bright, it is enhanced by the people face in the B video frame.", "FIG.", "13 is an extended embodiment based on FIG.", "12.In the embodiment of FIG.", "12, the brightness of A video frames is all higher than which of the B video frames.", "However, in the embodiment of FIG.", "13, the brightness of some A video frames is higher than which of corresponding B video frames (ex.", "A video frames AF_1, AF_4), but the brightness of some A video frames is lower than which of corresponding B video frames (ex.", "A video frames AF_2, AF_3).", "Therefore, for either the embodiment in FIG.", "12 or the embodiment in FIG.", "13, brightness of the A video frame and the B video frame is, analyzed to determine if anyone has a predetermined brightness, and then the video frame having a brightness closer to the predetermined brightness is determined as the enhancing standard video frame, such that the other video frame is enhanced by the enhancing standard video frame.", "The enhancing standard video frame can be applied to all video frames of a video sequence after it is determined.", "However, if the enhancing standard video frame is captured by the major camera, the video frame enhanced by the enhancing standard video frame has to be warped based on the corresponding video frame captured by the major camera, so as to generate the target single view video frame.", "For example, in one embodiment of FIG.", "12, if the A video frame is determined as the enhanced video frame, all A video frames are enhanced based on video frames for B video frames.", "Alternatively, the enhancing standard video frame can be applied to only some video frames for the video sequence after it is determined, and the enhancing standard video frame can be changed in such case.", "For example, in FIG.", "13, the A video frames AF_2, AF_3 are enhancing standard video frame for the B video frames BF_2, B_3, but the B video frames BF_2, BF 3 are enhancing standard video frame for the A video frames AF_2, AF 3.Such variation should fall in the scope of the present application.", "In view of the embodiments illustrated in FIG.", "6-FIG.", "11, the target single view video frames can be generated by the video frames from the major camera, based on the camera parameter such as video frame rate or video frame capturing parameter such as brightness or blur level.", "Therefore, the embodiments illustrated in FIG.", "6-FIG.", "11 can be summarized as: A video frame processing method comprising: (a) capturing at least one first video frame via a first camera utilizing a first camera parameter; (b) capturing at least one second video frame via a second camera utilizing a first camera parameter, wherein the:second camera parameter is different from the first camera parameter; and (c) generating a target single view video frame corresponding to each specific time point according to at least one first video frame, based on the first camera parameter and the second camera parameter.", "Incase note the first camera and the second camera here only indicate two different cameras, and are not limited to have the same parameters (ex.", "resolution, frame rate) as which the first camera and the second camera.", "Please note the corresponding relations of the first/second cameras and the A/B cameras are not fixed.", "For example, in one embodiment the video frame processing method comprises: determining if the, first video frame corresponding to the specific time point exists; if yes, selecting the first video frame as the target single view video frame; and if not, interpolating a target single view video frame from one of the second video frames corresponding to the specific time point and one or more adjacent frames captured by the first camera and the second camera.", "In such case the first camera indicates the A camera, and the second camera indicates the B camera.", "In another embodiment, the video frame processing method comprises: generating the target single view frame according to one candidate first frame, and at least one of: at least first video frame prior to or after the candidate first video frame, and at least second video frame prior to or after the candidate first video frame.", "In such case the first camera indicates the B camera, and the second camera indicates the A camera.", "In view of above-mentioned embodiments, the target single view video frames can be generated from video frames with different camera parameters and video frame capturing parameters.", "Therefore a better tar get single view video, frame can be acquired, Those skilled in the art will readily observe that numerous modifications and alterations of the device and method may be made while retaining the teachings of the invention.", "Accordingly, the above disclosure should be construed as limited only by the metes and bounds of the appended claims." ] ]
Patent_15874243
[ [ "PREEMPTIVE NOTIFICATIONS FOR ELECTRONIC TRANSMISSIONS", "Embodiments relate to systems and methods for electronically conditioning transmission of communications based on results of a connection assessment.", "An electronic file is executed at an electronic device, which causes a first query and a second query to be presented.", "A first query response and a second query response are identified.", "The first query response is stored in a locked configuration that inhibits the ability to modify the first query response to the first query.", "The second query response is stored but is not stored in the locked configuration.", "Query response data is generated that includes an identifier of the second query, an identifier of the second query response and an identifier of the electronic device.", "A connection variable is determined by assessing one or more network connections available to the electronic device.", "When a transmission condition is satisfied, the query response data is transmitted to another device." ], [ "1.A system for electronically conditioning transmission of communications based on results of a connection assessment, the system comprising: a query response engine that: identifies a first query response corresponding to a first query; stores the first query response in a locked configuration, the locked configuration inhibiting an ability to modify the first query response to the first query; identifies a second query response corresponding to a second query; and stores the second query response, the second query response not being stored in a locked configuration and being stored in a configuration that enables the stored second query response to be modified; generates query response data associated with the first query response or the second query response a connection assessor that: determines a connection variable by assessing one or more network connections available to a query response transmitter; and determines whether a transmission condition is satisfied based on the connection variable, the determination including comparing the connection variable to a threshold, a result of the determination indicating that the transmission condition is satisfied when the connection variable exceeds the threshold; and the query response transmitter that, when it is determined that the transmission condition is satisfied, transmits the query response data from the query response transmitter of the system to another device.", "2.The system for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 1, wherein the query response engine further retrieves, for each of the first query and the second query, configuration data that indicates whether a corresponding query response is to be stored in the locked configuration.", "3.The system for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 1, wherein: the query response engine further: determines, subsequent to the generating of the query response data, that the second query response is to be changed to a different second query response; modifies the stored second query response to be the different second query response; and generates new query response data that includes an identifier of the second query, an identifier of the different second query response and an identifier of an electronic device; the connection assessor that: determines an updated connection variable by assessing one or more network connections available to the electronic device; and determines whether the transmission condition is satisfied based on the updated connection variable; and the query response transmitter further transmits the new query response data when it is determined that the transmission condition is satisfied based on the updated connection variable.", "4.The system for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 1, wherein the query response engine further: determines, subsequent to the generating of the query response data and based on a time, that a configuration of the second query response is to be changed to the locked configuration; and updates the configuration of the second query response to the locked configuration.", "5.The system for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 1, wherein the system further comprises: a file retriever that receives, at an electronic device, one or more electronic files; and an access engine that executes at least one of the one or more electronic files, wherein the execution causes each of the first query and the second query to be presented at the electronic device.", "6.The system for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 5, wherein: the file retriever further receives, at the electronic device, a set of electronic files, the set of electronic files including the one or more electronic files, the one or more electronic files including a first executable file compatible with a first browser, the set of electronic files including a second executable file compatible with a second browser; and the access engine further: identifies that code for the first browser is being executed on the electronic device; and selects the first executable file for execution based on the identification that code for the first browser is being executed, wherein the second executable file is not executed at the electronic device.", "7.The system for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 1, wherein determining that the transmission condition is not satisfied further causes the query response data to be aggregated with other query response data, and wherein the query response transmitter transmits the aggregated query response data and other query response data upon a subsequent determination that the transmission condition is satisfied.", "8.The system for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 1, wherein the connection variable is indicative of a strength of a connection.", "9.A computer-implemented method for electronically conditioning transmission of communications based on results of a connection assessment, the method comprising: identifying, at an electronic device, a first query response corresponding to a first query; storing, at the electronic device, the first query response in a locked configuration, the locked configuration inhibiting an ability to modify the first query response to the first query; identifying, at the electronic device, a second query response corresponding to a second query; storing, at the electronic device, the second query response, the second query response not being stored in a locked configuration and being stored in a configuration that enables the stored second query response to be modified; generating, at the electronic device, query response data associated with the first query response or the second query response; determining, at the electronic device, a connection variable by assessing one or more network connections available to the electronic device; determining, at the electronic device, whether a transmission condition is satisfied based on the connection variable, the determination including comparing the connection variable to a threshold, a result of the determination indicating that the transmission condition is satisfied when the connection variable exceeds the threshold; and when it is determined that the transmission condition is satisfied, transmitting the query response data from the electronic device to another device.", "10.The method for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 9, further comprising: retrieving, for each of the first query and the second query, configuration data that indicates whether a corresponding query response is to be stored in the locked configuration.", "11.The method for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 9, further comprising: determining, subsequent to the generating the query response data, that the second query response is to be changed to a different second query response; modifying the stored second query response to be the different second query response; generating new query response data that includes an identifier of the second query, an identifier of the different second query response and an identifier of the electronic device; determining an updated connection variable by assessing one or more network connections available to the electronic device; determining whether the transmission condition is satisfied based on the updated connection variable; and transmitting the new query response data when it is determined that the transmission condition is satisfied based on the updated connection variable.", "12.The method for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 9, further comprising: determining, subsequent to the generating the query response data and based on a time, that a configuration of the second query response is to be changed to the locked configuration; and updating the configuration of the second query response to the locked configuration.", "13.The method for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 9, further comprising receiving, at an electronic device, one or more electronic files; and executing at least one of the one or more electronic files, wherein the execution causes each of the first query and the second query to be presented at the electronic device.", "14.The method for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 13, further comprising: receiving, at the electronic device, a set of electronic files, the set of electronic files including the one or more electronic files, the one or more electronic files including a first executable file compatible with a first browser, the set of electronic files including a second executable file compatible with a second browser; identifying that code for the first browser is being executed on the electronic device; and selecting the first executable file for execution based on the identification that code for the first browser is being executed, wherein the second executable file is not executed at the electronic device.", "15.The method for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 9, wherein determining that the transmission condition is not satisfied further causes the query response data to be aggregated with other query response data, and wherein the method further comprises: transmitting the aggregated query response data and other query response data upon a subsequent determination that the transmission condition is satisfied.", "16.The method for electronically conditioning transmission of communications based on results of the connection assessment as recited in claim 9, wherein the connection variable is indicative of a strength of a connection.", "17.A computer-program product tangibly embodied in a non-transitory machine-readable storage medium, including instructions configured to cause one or more data processors to perform actions including: identifying a first query response corresponding to a first query; storing the first query response in a locked configuration, the locked configuration inhibiting an ability to modify the first query response to the first query; identifying a second query response corresponding to a second query; storing the second query response, the second query response not being stored in a locked configuration and being stored in a configuration that enables the stored second query response to be modified; generating query response data associated with the first query response or the second query response; determining a connection variable by assessing one or more network connections available to the machine-readable storage medium of an electronic device; determining whether a transmission condition is satisfied based on the connection variable, the determination including comparing the connection variable to a threshold, a result of the determination indicating that the transmission condition is satisfied when the connection variable exceeds the threshold; and when it is determined that the transmission condition is satisfied, facilitating a transmission of the query response data from the electronic device to another device.", "18.The computer-program product as recited in claim 17, wherein the actions further include: retrieving, for each of the first query and the second query, configuration data that indicates whether a corresponding query response is to be stored in the locked configuration.", "19.The computer-program product as recited in claim 17, wherein the actions further include: determining, subsequent to the generating the query response data, that the second query response is to be changed to a different second query response; modifying the stored second query response to be the different second query response; generating new query response data that includes an identifier of the second query, an identifier of the different second query response and an identifier of the electronic device; determining an updated connection variable by assessing one or more network connections available to the electronic device; determining whether the transmission condition is satisfied based on the updated connection variable; and facilitating a transmission of the new query response data when it is determined that the transmission condition is satisfied based on the updated connection variable.", "20.The computer-program product as recited in claim 17, wherein the actions further include: determining, subsequent to the generating the query response data and based on a time, that a configuration of the second query response is to be changed to the locked configuration; and updating the configuration of the second query response to the locked configuration." ], [ "<SOH> BACKGROUND <EOH>Communication exchanges between devices are becoming increasingly frequent and important.", "In some instances, a first communication is received at a device, and one or more second communications are generated that include data responsive to content in the first communication.", "However, circumstances may exist where a reliability at which the second communication(s) can be successfully transmitted is questionable or poor.", "Thus, techniques that identify transmission conditions and transmission characteristics would be advantageous." ], [ "<SOH> SUMMARY <EOH>In some embodiments, a system for electronically conditioning transmission of communications based on results of a connection assessment is provided.", "A file retriever receives, at an electronic device, one or more electronic files.", "An access engine executes at least one of the one or more electronic files, wherein the execution causes each of a first query and a second query to be presented at the electronic device.", "A query response engine identifies a first query response corresponding to the first query and stores the first query response in a locked configuration.", "The locked configuration inhibits the ability to modify the first query response to the first query.", "The query engine also identifies a second query response corresponding to the second query and stores the second query response.", "The second query response is not stored in a locked configuration and is stored in a configuration that enables the stored second query response to be modified.", "The query engine further generates query response data that includes an identifier of each of one or more queries, an identifier of each of one or more query responses, and an identifier of the electronic device, the one or more queries including the second query, and the one or more query responses includes the second query response.", "A connection assessor determines a connection variable by assessing one or more network connections available to the electronic device and determines whether a transmission condition is satisfied based on the connection variable.", "The determination includes comparing the connection variable to a threshold.", "A result of the determination indicates that the transmission condition is satisfied when the connection variable exceeds the threshold.", "A query response transmitter transmits, when it is determined that the transmission condition is satisfied, the query response data from the electronic device to another device.", "In some embodiments, a computer-implemented method for electronically conditioning transmission of communications based on results of a connection assessment is provided.", "At an electronic device, one or more electronic files are executed, which causes each of a first query and a second query to be presented at the electronic device.", "A first query response corresponding to the first query is identified, The first query response is stored in a locked configuration that inhibits the ability to modify the first query response to the first query.", "A second query response corresponding to the second query is identified and stored at the electronic device.", "The second query response is not stored in a locked configuration and is stored in a configuration that enables the stored second query response to be modified.", "Query response data is generated that includes an identifier of each of one or more queries, an identifier of each of one or more query responses, and an identifier of the electronic device.", "The one or more queries include the second query, and the one or more query responses include the second query response.", "A connection variable is determined by assessing one or more network connections available to the electronic device.", "It is determined whether a transmission condition is satisfied based on the connection variable.", "The determination includes comparing the connection variable to a threshold.", "A result of the determination indicates that the transmission condition is satisfied when the connection variable exceeds the threshold.", "When it is determined that the transmission condition is satisfied, the query response data is transmitted from the electronic device to another device.", "A set of electronic files is received that include the one or more electronic files.", "The one or more electronic files includes a first executable file compatible with a first browser.", "The set of electronic files includes a second executable file compatible with a second browser.", "It is identified that code for the first browser is being executed on the electronic device.", "The first executable file for execution is selected based on the identification that code for the first browser is being executed and the second executable file is not executed at the electronic device.", "In some embodiments, a computer-program product tangibly embodied in a non-transitory machine-readable storage medium, including instructions configured to cause one or more data processors to perform one or more actions from one or more processes disclosed herein.", "In some embodiments, a computer program product is provided that is tangibly embodied in a non-transitory machine-readable storage medium.", "The computer program product includes instructions configured to cause one or more data processors to perform actions including part or all of a method disclosed herein.", "Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter.", "It should be understood that the detailed description and specific examples, while indicating various embodiments, are intended for purposes of illustration only and are not intended to necessarily limit the scope of the disclosure." ], [ "CROSS-REFERENCE OF RELATED APPLICATIONS This application is a continuation of U.S. Non-Provisional application Ser.", "No.", "15/842,653, filed on Dec. 14, 2017 and entitled “CONDITIONED TRANSMISSION OF ELECTRONIC COMMUNICATIONS”, which is a continuation of U.S. Non-Provisional application Ser.", "No.", "14/753,858, filed on Jun.", "29, 2015 and entitled “CONDITIONED TRANSMISSION OF QUERY RESPONSES AND CONNECTION ASSESSMENTS”, which is a continuation-in-part of U.S. application Ser.", "No.", "14/222,317, filed on Mar.", "21, 2014 and entitled “SEMI-NETWORK INDEPENDENT EDUCATIONAL ELECTRONIC EXAM ENGINE”, which are herein incorporated by reference in their entirety for all purposes.", "FIELD This disclosure relates in general to methods and systems for executing files and electronically conditioning transmission of communications based on results of a connection assessment.", "BACKGROUND Communication exchanges between devices are becoming increasingly frequent and important.", "In some instances, a first communication is received at a device, and one or more second communications are generated that include data responsive to content in the first communication.", "However, circumstances may exist where a reliability at which the second communication(s) can be successfully transmitted is questionable or poor.", "Thus, techniques that identify transmission conditions and transmission characteristics would be advantageous.", "SUMMARY In some embodiments, a system for electronically conditioning transmission of communications based on results of a connection assessment is provided.", "A file retriever receives, at an electronic device, one or more electronic files.", "An access engine executes at least one of the one or more electronic files, wherein the execution causes each of a first query and a second query to be presented at the electronic device.", "A query response engine identifies a first query response corresponding to the first query and stores the first query response in a locked configuration.", "The locked configuration inhibits the ability to modify the first query response to the first query.", "The query engine also identifies a second query response corresponding to the second query and stores the second query response.", "The second query response is not stored in a locked configuration and is stored in a configuration that enables the stored second query response to be modified.", "The query engine further generates query response data that includes an identifier of each of one or more queries, an identifier of each of one or more query responses, and an identifier of the electronic device, the one or more queries including the second query, and the one or more query responses includes the second query response.", "A connection assessor determines a connection variable by assessing one or more network connections available to the electronic device and determines whether a transmission condition is satisfied based on the connection variable.", "The determination includes comparing the connection variable to a threshold.", "A result of the determination indicates that the transmission condition is satisfied when the connection variable exceeds the threshold.", "A query response transmitter transmits, when it is determined that the transmission condition is satisfied, the query response data from the electronic device to another device.", "In some embodiments, a computer-implemented method for electronically conditioning transmission of communications based on results of a connection assessment is provided.", "At an electronic device, one or more electronic files are executed, which causes each of a first query and a second query to be presented at the electronic device.", "A first query response corresponding to the first query is identified, The first query response is stored in a locked configuration that inhibits the ability to modify the first query response to the first query.", "A second query response corresponding to the second query is identified and stored at the electronic device.", "The second query response is not stored in a locked configuration and is stored in a configuration that enables the stored second query response to be modified.", "Query response data is generated that includes an identifier of each of one or more queries, an identifier of each of one or more query responses, and an identifier of the electronic device.", "The one or more queries include the second query, and the one or more query responses include the second query response.", "A connection variable is determined by assessing one or more network connections available to the electronic device.", "It is determined whether a transmission condition is satisfied based on the connection variable.", "The determination includes comparing the connection variable to a threshold.", "A result of the determination indicates that the transmission condition is satisfied when the connection variable exceeds the threshold.", "When it is determined that the transmission condition is satisfied, the query response data is transmitted from the electronic device to another device.", "A set of electronic files is received that include the one or more electronic files.", "The one or more electronic files includes a first executable file compatible with a first browser.", "The set of electronic files includes a second executable file compatible with a second browser.", "It is identified that code for the first browser is being executed on the electronic device.", "The first executable file for execution is selected based on the identification that code for the first browser is being executed and the second executable file is not executed at the electronic device.", "In some embodiments, a computer-program product tangibly embodied in a non-transitory machine-readable storage medium, including instructions configured to cause one or more data processors to perform one or more actions from one or more processes disclosed herein.", "In some embodiments, a computer program product is provided that is tangibly embodied in a non-transitory machine-readable storage medium.", "The computer program product includes instructions configured to cause one or more data processors to perform actions including part or all of a method disclosed herein.", "Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter.", "It should be understood that the detailed description and specific examples, while indicating various embodiments, are intended for purposes of illustration only and are not intended to necessarily limit the scope of the disclosure.", "BRIEF DESCRIPTION OF THE DRAWINGS The present disclosure is described in conjunction with the appended figures: FIG.", "1 is a block diagram showing illustrating an example of a content distribution network.", "FIG.", "2 is a block diagram illustrating a computer server and computing environment within a content distribution network.", "FIG.", "3 is a block diagram illustrating an embodiment of one or more data store servers within a content distribution network.", "FIG.", "4 is a block diagram illustrating an embodiment of one or more content management servers within a content distribution network.", "FIG.", "5 is a block diagram illustrating the physical and logical components of a special-purpose computer device within a content distribution network.", "FIG.", "6 depicts a block diagram of an embodiment of an query management system; FIG.", "7 illustrates a flowchart of an embodiment of a process for retrieving an power file at an electronic device; FIG.", "8 illustrates a flowchart of an embodiment of a process for identifying and transmitting query responses; FIG.", "9 illustrates a flowchart of an embodiment of a process for conditionally transmitting query responses; FIG.", "10 illustrates a flowchart of an embodiment of a process for caching executable files; FIG.", "11 illustrates a flowchart of an embodiment of a process for caching query responses; FIG.", "12 illustrates a flowchart of an embodiment of a process for electronically executing an executable file; and FIG.", "13 illustrates a flow diagram of an embodiment of a process for updating query response data based on conflict-resolution indications.", "In the appended figures, similar components and/or features can have the same reference label.", "Further, various components of the same type can be distinguished by following the reference label by a dash and a second label that distinguishes among the similar components.", "If only the first reference label is used in the specification, the description is applicable to any one of the similar components having the same first reference label irrespective of the second reference label.", "DETAILED DESCRIPTION The ensuing description provides illustrative embodiment(s) only and is not intended to limit the scope, applicability or configuration of the disclosure.", "Rather, the ensuing description of the illustrative embodiment(s) will provide those skilled in the art with an enabling description for implementing a preferred exemplary embodiment.", "It is understood that various changes can be made in the function and arrangement of elements without departing from the spirit and scope as set forth in the appended claims.", "With reference now to FIG.", "1, a block diagram is shown illustrating various components of a content distribution network (CDN) 100 which implements and supports certain embodiments and features described herein.", "Content distribution network 100 may include one or more content management servers 102.As discussed below in more detail, content management servers 102 may be any desired type of server including, for example, a rack server, a tower server, a miniature server, a blade server, a mini rack server, a mobile server, an ultra-dense server, a super server, or the like, and may include various hardware components, for example, a motherboard, a processing units, memory systems, hard drives, network interfaces, power supplies, etc.", "Content management server 102 may include one or more server farms, clusters, or any other appropriate arrangement and/or combination or computer servers.", "Content management server 102 may act according to stored instructions located in a memory subsystem of the server 102, and may run an operating system, including any commercially available server operating system and/or any other operating systems discussed herein.", "The content distribution network 100 may include one or more data store servers 104, such as database servers and file-based storage systems.", "Data stores 104 may comprise stored data relevant to the functions of the content distribution network 100.Illustrative examples of data stores 104 that may be maintained in certain embodiments of the content distribution network 100 are described below in reference to FIG.", "3.In some embodiments, multiple data stores may reside on a single server 104, either using the same storage components of server 104 or using different physical storage components to assure data security and integrity between data stores.", "In other embodiments, each data store may have a separate dedicated data store server 104.Content distribution network 100 also may include one or more user devices 106 (e.g., electronic user devices) and/or supervisor devices 110 (e.g., electronic supervisor devices).", "User devices 106 and supervisor devices 110 may display content received via the content distribution network 100, and may support various types of user interactions with the content.", "User devices 106 and supervisor devices 110 may include mobile devices such as smartphones, tablet computers, personal digital assistants, and wearable computing devices.", "Such mobile devices may run a variety of mobile operating systems, and may be enabled for Internet, e-mail, short message service (SMS), Bluetooth®, mobile radio-frequency identification (M-RFID), and/or other communication protocols.", "Other user devices 106 and supervisor devices 110 may be general purpose personal computers or special-purpose computing devices including, by way of example, personal computers, laptop computers, workstation computers, projection devices, and interactive room display systems.", "Additionally, user devices 106 and supervisor devices 110 may be any other electronic devices, such as a thin-client computers, an Internet-enabled gaming systems, business or home appliances, and/or a personal messaging devices, capable of communicating over network(s) 120.In different contexts of content distribution networks 100, user devices 106 and supervisor devices 110 may correspond to different types of specialized devices, for example, student devices and teacher devices in an educational network, employee devices and presentation devices in a company network, different gaming devices in a gaming network, etc.", "In some embodiments, user devices 106 and supervisor devices 110 may operate in the same physical location 107, such as a classroom or conference room.", "In such cases, the devices may contain components that support direct communications with other nearby devices, such as a wireless transceivers and wireless communications interfaces, Ethernet sockets or other Local Area Network (LAN) interfaces, etc.", "In other implementations, the user devices 106 and supervisor devices 110 need not be used at the same location 107, but may be used in remote geographic locations in which each user device 106 and supervisor device 110 may use security features and/or specialized hardware (e.g., hardware-accelerated SSL and HTTPS, WS-Security, firewalls, etc.)", "to communicate with the content management server 102 and/or other remotely located user devices 106.Additionally, different user devices 106 and supervisor devices 110 may be assigned different designated roles, such as presenter devices, teacher devices, administrator devices, or the like, and in such cases the different devices may be provided with additional hardware and/or software components to provide content and support user capabilities not available to the other devices.", "The content distribution network 100 also may include a privacy server 108 that maintains private user information at the privacy server 108 while using applications or services hosted on other servers.", "For example, the privacy server 108 may be used to maintain private data of a user within one jurisdiction even though the user is accessing an application hosted on a server (e.g., the content management server 102) located outside the jurisdiction.", "In such cases, the privacy server 108 may intercept communications between a user device 106 or supervisor device 110 and other devices that include private user information.", "The privacy server 108 may create a token or identifier that does not disclose the private information and may use the token or identifier when communicating with the other servers and systems, instead of using the user's private information.", "As illustrated in FIG.", "1, the content management server 102 may be in communication with one or more additional servers, such as a content server 112, a user data server 112, and/or an administrator server 116.Each of these servers may include some or all of the same physical and logical components as the content management server(s) 102, and in some cases, the hardware and software components of these servers 112-116 may be incorporated into the content management server(s) 102, rather than being implemented as separate computer servers.", "Content server 112 may include hardware and software components to generate, store, and maintain the content resources for distribution to user devices 106 and other devices in the network 100.For example, in content distribution networks 100 used for professional training and educational purposes, content server 112 may include data stores of training materials, presentations, interactive programs and simulations, course models, course outlines, and various training interfaces that correspond to different materials and/or different types of user devices 106.In content distribution networks 100 used for media distribution, interactive gaming, and the like, a content server 112 may include media content files such as music, movies, television programming, games, and advertisements.", "User data server 114 may include hardware and software components that store and process data for multiple users relating to each user's activities and usage of the content distribution network 100.For example, the content management server 102 may record and track each user's system usage, including their user device 106, content resources accessed, and interactions with other user devices 106.This data may be stored and processed by the user data server 114, to support user tracking and analysis features.", "For instance, in the professional training and educational contexts, the user data server 114 may store and analyze each user's training materials viewed, presentations attended, courses completed, interactions, evaluation results, and the like.", "The user data server 114 may also include a repository for user-generated material, such as evaluations and tests completed by users, and documents and assignments prepared by users.", "In the context of media distribution and interactive gaming, the user data server 114 may store and process resource access data for multiple users (e.g., content titles accessed, access times, data usage amounts, gaming histories, user devices and device types, etc.).", "Administrator server 116 may include hardware and software components to initiate various administrative functions at the content management server 102 and other components within the content distribution network 100.For example, the administrator server 116 may monitor device status and performance for the various servers, data stores, and/or user devices 106 in the content distribution network 100.When necessary, the administrator server 116 may add or remove devices from the network 100, and perform device maintenance such as providing software updates to the devices in the network 100.Various administrative tools on the administrator server 116 may allow authorized users to set user access permissions to various content resources, monitor resource usage by users and devices 106, and perform analyses and generate reports on specific network users and/or devices (e.g., resource usage tracking reports, training evaluations, etc.).", "The content distribution network 100 may include one or more communication networks 120.Although only a single network 120 is identified in FIG.", "1, the content distribution network 100 may include any number of different communication networks between any of the computer servers and devices shown in FIG.", "1 and/or other devices described herein.", "Communication networks 120 may enable communication between the various computing devices, servers, and other components of the content distribution network 100.As discussed below, various implementations of content distribution networks 100 may employ different types of networks 120, for example, computer networks, telecommunications networks, wireless networks, and/or any combination of these and/or other networks.", "It will be appreciated that content distribution network 100 can include one or more other devices and/or servers not depicted in FIG.", "1.For example, content distribution network 100 (e.g., which can include or can be a central server) can include a relay device (e.g., which can include or can be a proctor device) that can be connected to one or more user devices 106 and to a remote content management server 102.The relay device may be, in some instances, located in a same room and/or a same building as the one or more user devices.", "Depending on the embodiment, the relay device may be connected to content management server 102 and the one or more user devices 106 over a same or different types of networks.", "For example, the relay device may be connected to content management server 102 via a wireless connection (e.g., WiFi) and to the one or more user devices 106 via a short-range (e.g., Bluetooth) connection, wired network and/or local network.", "The relay device may retrieve one or more files (e.g., a power file and/or one or more executable files) from content management server 102.In some instances, the one or more files are encrypted, and the relay device may, or may not, decrypt the file(s).", "The relay device may be configured to encrypt (e.g., encrypt a file not encrypted when received; encrypt a decrypted file; or doubly encrypt a file).", "The encryption may be configured such that an encrypted file transmitted to each of multiple user devices can be decrypted with a same key, or the encryption can include a layer specific to a user device.", "For example, a key (or part thereof) may correspond to a particular user, account or user device.", "A key may include multiple components, with one component being user-specific; one component being specific to a file or file class (e.g., a particular exam); one component being specific to a date; and/or one component being specific to a location.", "The relay device may subsequently (e.g., at or after a defined time and/or upon receiving an instruction from content management server 102 or request from a user device) transmit the one or more files to a user device.", "The one or more files can include one or more executable files.", "When the one or more files are received at the user device, the user device may decrypt the file(s) (e.g., individually or a collection of the files) using a stored key or a derived key.", "For example, the one or more files can be transmitted with or in association with a file that identifies a protocol for generating a key (e.g., using an identifier of a time, location, user, user device and/or account).", "When executed, an executable file can facilitate or cause one or more queries (e.g., one or more questions) to be presented at an executing device.", "The execution can further cause or facilitate a response to each of the one or more queries to be identified.", "For example, a input can be provided at an interface, which can be associated with response.", "The response can be stored in a locked or unlocked configuration.", "A locked configuration can be one that inhibits or prevents the response from being changed via subsequent input.", "For example, once input identifies a particular response for a given query, storing the particular response in a locked configuration can prevent identifying a different response for that query.", "In some instances, one or more responses (e.g., identified while executing a given executable file and/or provided in response to a query in a given exam) are stored in a locked configuration and one or more other responses (e.g., identified while executing the same given executable file and/or provided in response to another query in the same given exam) are stored in an unlocked configuration.", "In one instance, a response is stored in a locked configuration when a particular input has been received at the executing user device (e.g., submitting or locking a response).", "In one instance, a response is stored in a locked configuration (which can include changing the configuration to a locked configuration) after a defined time period has passed or a defined number of other responses have been provided since identifying the response.", "In one instance, a response is stored in a locked configuration when one or more subsequent queries have been identified based on the response.", "In one instance, a response is stored in a locked configuration when response data identifying the response has been transmitted or successfully transmitted (e.g., to a relay device or content management server 102).", "In one instance, a structure file identifies which responses are to be stored in a locked configuration, whether all responses are to be stored in a locked (or unlocked) configuration and/or any conditions (e.g., time passage, query adaptation, local input, etc.)", "for storing a response in a locked configuration.", "Response data can include one or more responses (e.g., identified in association with a corresponding one or more questions).", "Response data may further include an identifier of a user, electronic device, user account, and/or one more times (e.g., a time at which response data is generated or a time at which each of one or more responses were provided).", "Response data may be transmitted (e.g., to a relay device or content management server 102).", "The response data may be transmitted, for example, upon a defined number of responses being identified and/or stored; at one or more defined times; at defined time intervals; upon receiving a local instruction (e.g., a submission instruction or response-confirmation indication) initiating the transmission; and/or upon receiving a request for response data (e.g., from a relay device).", "The transmission may further and/or alternatively depend on network factors.", "For example, transmission of response data may require that a threshold number (e.g., at least one or at least a defined non-one number) of networks are available; that a threshold number of networks having a network strength greater than or equal to a strength threshold (e.g., a non-zero strength threshold) are available; that a threshold number of networks of a particular type (e.g., short-range network, WiFi network, or a Bluetooth network) are available; that a particular or threshold number of networks have an upload speed that is at least a defined upload speed threshold; that a particular or threshold number of networks have a download speed that is at least a defined download speed threshold; and/or that a particular or threshold number of networks have a latency less than or equal to a defined latency threshold.", "When response data is transmitted to the relay device, the relay device may subsequently transmit the response data (e.g., and an appended or processed version thereof) to content management server 102.With reference to FIG.", "2, an illustrative distributed computing environment 200 is shown including a computer server 202, four client computing devices 206, and other components that may implement certain embodiments and features described herein.", "In some embodiments, the server 202 may correspond to the content management server 102 discussed above in FIG.", "1, and the client computing devices 206 may correspond to the user devices 106.However, the computing environment 200 illustrated in FIG.", "2 may correspond to any other combination of devices and servers configured to implement a client-server model or other distributed computing architecture.", "In one instance, computer server 202 may correspond to a relay device.", "In one instance, computer server 202 may correspond to a distributed system, such as one that resides in part at a relay device and in part at a remote content management server 102 (e.g., in a cloud).", "Client devices 206 may be configured to receive and execute client applications over one or more networks 220.Such client applications may be web browser based applications and/or standalone software applications, such as mobile device applications.", "Server 202 may be communicatively coupled with the client devices 206 via one or more communication networks 220.Client devices 206 may receive client applications from server 202 or from other application providers (e.g., public or private application stores).", "Server 202 may be configured to run one or more server software applications or services, for example, web-based or cloud-based services, to support content distribution and interaction with client devices 206.Users operating client devices 206 may in turn utilize one or more client applications (e.g., virtual client applications) to interact with server 202 to utilize the services provided by these components.", "Various different subsystems and/or components 204 may be implemented on server 202.Users operating the client devices 206 may initiate one or more client applications to use services provided by these subsystems and components.", "The subsystems and components within the server 202 and client devices 206 may be implemented in hardware, firmware, software, or combinations thereof.", "Various different system configurations are possible in different distributed computing systems 200 and content distribution networks 100.The embodiment shown in FIG.", "2 is thus one example of a distributed computing system and is not intended to be limiting.", "Although exemplary computing environment 200 is shown with four client computing devices 206, any number of client computing devices may be supported.", "Other devices, such as specialized sensor devices, etc., may interact with client devices 206 and/or server 202.As shown in FIG.", "2, various security and integration components 208 may be used to send and manage communications between the server 202 and user devices 206 over one or more communication networks 220.The security and integration components 208 may include separate servers, such as web servers and/or authentication servers, and/or specialized networking components, such as firewalls, routers, gateways, load balancers, and the like.", "In some cases, the security and integration components 208 may correspond to a set of dedicated hardware and/or software operating at the same physical location and under the control of same entities as server 202.For example, components 208 may include one or more dedicated web servers and network hardware in a datacenter or a cloud infrastructure.", "In other examples, the security and integration components 208 may correspond to separate hardware and software components which may be operated at a separate physical location and/or by a separate entity.", "Security and integration components 208 may implement various security features for data transmission and storage, such as authenticating users and restricting access to unknown or unauthorized users.", "In various implementations, security and integration components 208 may provide, for example, a file-based integration scheme or a service-based integration scheme for transmitting data between the various devices in the content distribution network 100.Security and integration components 208 also may use secure data transmission protocols and/or encryption for data transfers, for example, File Transfer Protocol (FTP), Secure File Transfer Protocol (SFTP), and/or Pretty Good Privacy (PGP) encryption.", "In some embodiments, one or more web services may be implemented within the security and integration components 208 and/or elsewhere within the content distribution network 100.Such web services, including cross-domain and/or cross-platform web services, may be developed for enterprise use in accordance with various web service standards, such as the Web Service Interoperability (WS-I) guidelines.", "For example, some web services may use the Secure Sockets Layer (SSL) or Transport Layer Security (TLS) protocol to provide secure connections between the server 202 and user devices 206.SSL or TLS may use HTTP or HTTPS to provide authentication and confidentiality.", "In other examples, web services may be implemented using the WS-Security standard, which provides for secure SOAP messages using XML encryption.", "In other examples, the security and integration components 208 may include specialized hardware for providing secure web services.", "For example, security and integration components 208 may include secure network appliances having built-in features such as hardware-accelerated SSL and HTTPS, WS-Security, and firewalls.", "Such specialized hardware may be installed and configured in front of any web servers, so that any external devices may communicate directly with the specialized hardware.", "Communication network(s) 220 may be any type of network familiar to those skilled in the art that can support data communications using any of a variety of commercially-available protocols, including without limitation, TCP/IP (transmission control protocol/Internet protocol), SNA (systems network architecture), IPX (Internet packet exchange), Secure Sockets Layer (SSL) or Transport Layer Security (TLS) protocols, Hyper Text Transfer Protocol (HTTP) and Secure Hyper Text Transfer Protocol (HTTPS), and the like.", "Merely by way of example, network(s) 220 may be local area networks (LAN), such as one based on Ethernet, Token-Ring and/or the like.", "Network(s) 220 also may be wide-area networks, such as the Internet.", "Networks 220 may include telecommunication networks such as a public switched telephone networks (PSTNs), or virtual networks such as an intranet or an extranet.", "Infrared and wireless networks (e.g., using the Institute of Electrical and Electronics (IEEE) 802.11 protocol suite or other wireless protocols) also may be included in networks 220.Computing environment 200 also may include one or more data stores 210 and/or back-end servers 212.In certain examples, the data stores 210 may correspond to data store server(s) 104 discussed above in FIG.", "1, and back-end servers 212 may correspond to the various back-end servers 112-116.Data stores 210 and servers 212 may reside in the same datacenter or may operate at a remote location from server 202.In some cases, one or more data stores 210 may reside on a non-transitory storage medium within the server 202.Other data stores 210 and back-end servers 212 may be remote from server 202 and configured to communicate with server 202 via one or more networks 220.In certain embodiments, data stores 210 and back-end servers 212 may reside in a storage-area network (SAN).", "With reference to FIG.", "3, an illustrative set of data stores and/or data store servers is shown, corresponding to the data store servers 104 of the content distribution network 100 discussed above in FIG.", "1.One or more individual data stores 301-309 may reside in storage on a single computer server 104 (or a single server farm or cluster) under the control of a single entity, or may reside on separate servers operated by different entities and/or at remote locations.", "In some embodiments, data stores 301-309 may be accessed by the content management server 102 and/or other devices and servers within the network 100 (e.g., user devices 106, supervisor devices 110, administrator servers 116, etc.).", "Access to one or more of the data stores 301-309 may be limited or denied based on the processes, user credentials, and/or devices attempting to interact with the data store.", "In one instance, some or all of data stores 301-309 reside in storage on a remote server 104 and a corresponding data store for each of at least one of data stores 301-309 or another data store reside in a relay device.", "Thus, the relay device may receive data from the remote server and store the data locally (e.g., to facilitate subsequent transmission to a user device).", "Similarly, a corresponding data store for at least one of data stores 301-309 or another data store may reside at a user device 106.For example, a content management server 102 may provide select data from evaluation data store 308 to a relay device (which can store the data in a corresponding data store), which can transmit some or all of the data to a user device.", "The paragraphs below describe examples of specific data stores that may be implemented within some embodiments of a content distribution network 100.It should be understood that the below descriptions of data stores 301-309, including their functionality and types of data stored therein, are illustrative and non-limiting.", "Data stores server architecture, design, and the execution of specific data stores 301-309 may depend on the context, size, and functional requirements of a content distribution network 100.For example, in content distribution systems 100 used for professional training and educational purposes, separate databases or file-based storage systems may be implemented in data store server(s) 104 to store trainee and/or student data, trainer and/or professor data, training module data and content descriptions, training results, evaluation data, and the like.", "In contrast, in content distribution systems 100 used for media distribution from content providers to subscribers, separate data stores may be implemented in data stores server(s) 104 to store listings of available content titles and descriptions, content title usage statistics, subscriber profiles, account data, payment data, network usage statistics, etc.", "A user profile data store 301 may include information relating to the end users within the content distribution network 100.This information may include user characteristics such as the user names, access credentials (e.g., logins and passwords), user preferences, and information relating to any previous user interactions within the content distribution network 100 (e.g., requested content, posted content, content modules completed, training scores or evaluations, other associated users, etc.).", "An accounts data store 302 may generate and store account data for different users in various roles within the content distribution network 100.For example, accounts may be created in an accounts data store 302 for individual end users, supervisors, administrator users, and entities such as companies or educational institutions.", "Account data may include account types, current account status, account characteristics, and any parameters, limits, restrictions associated with the accounts.", "A content library data store 303 may include information describing the individual content items (or content resources) available via the content distribution network 100.In some embodiments, the library data store 303 may include metadata, properties, and other characteristics associated with the content resources stored in the content server 112.Such data may identify one or more aspects or content attributes of the associated content resources, for example, subject matter, access level, or skill level of the content resources, license attributes of the content resources (e.g., any limitations and/or restrictions on the licensable use and/or distribution of the content resource), price attributes of the content resources (e.g., a price and/or price structure for determining a payment amount for use or distribution of the content resource), rating attributes for the content resources (e.g., data indicating the evaluation or effectiveness of the content resource), and the like.", "In some embodiments, the library data store 303 may be configured to allow updating of content metadata or properties, and to allow the addition and/or removal of information relating to the content resources.", "A pricing data store 304 may include pricing information and/or pricing structures for determining payment amounts for providing access to the content distribution network 100 and/or the individual content resources within the network 100.In some cases, pricing may be determined based on a user's access to the content distribution network 100, for example, a time-based subscription fee, or pricing based on network usage and.", "In other cases, pricing may be tied to specific content resources.", "Certain content resources may have associated pricing information, whereas other pricing determinations may be based on the resources accessed, the profiles and/or accounts of the user, and the desired level of access (e.g., duration of access, network speed, etc.).", "Additionally, the pricing data store 304 may include information relating to compilation pricing for groups of content resources, such as group prices and/or price structures for groupings of resources.", "A license data store 305 may include information relating to licenses and/or licensing of the content resources within the content distribution network 100.For example, the license data store 305 may identify licenses and licensing terms for individual content resources and/or compilations of content resources in the content server 112, the rights holders for the content resources, and/or common or large-scale right holder information such as contact information for rights holders of content not included in the content server 112.A content access data store 306 may include access rights and security information for the content distribution network 100 and specific content resources.", "For example, the content access data store 306 may include login information (e.g., user identifiers, logins, passwords, etc.)", "that can be verified during user login attempts to the network 100.The content access data store 306 also may be used to store assigned user roles and/or user levels of access.", "For example, a user's access level may correspond to the sets of content resources and/or the client or server applications that the user is permitted to access.", "Certain users may be permitted or denied access to certain applications and resources based on their subscription level, training program, course/grade level, etc.", "Certain users may have supervisory access over one or more end users, allowing the supervisor to access all or portions of the end user's content, activities, evaluations, etc.", "Additionally, certain users may have administrative access over some users and/or some applications in the content management network 100, allowing such users to add and remove user accounts, modify user access permissions, perform maintenance updates on software and servers, etc.", "A source data store 307 may include information relating to the source of the content resources available via the content distribution network.", "For example, a source data store 307 may identify the authors and originating devices of content resources, previous pieces of data and/or groups of data originating from the same authors or originating devices, and the like.", "An evaluation data store 308 may include information used to direct the evaluation of users and content resources in the content management network 100.In some embodiments, the evaluation data store 308 may contain, for example, the analysis criteria and the analysis guidelines for evaluating users (e.g., trainees/students, gaming users, media content consumers, etc.)", "and/or for evaluating the content resources in the network 100.The evaluation data store 308 also may include information relating to evaluation processing tasks, for example, the identification of users and user devices 106 that have received certain content resources or accessed certain applications, the status of evaluations or evaluation histories for content resources, users, or applications, and the like.", "Evaluation criteria may be stored in the evaluation data store 308 including data and/or instructions in the form of one or several electronic rubrics or scoring guides for use in the evaluation of the content, users, or applications.", "The evaluation data store 308 also may include past evaluations and/or evaluation analyses for users, content, and applications, including relative rankings, characterizations, explanations, and the like.", "In addition to the illustrative data stores described above, data store server(s) 104 (e.g., database servers, file-based storage servers, etc.)", "may include one or more external data aggregators 309.External data aggregators 309 may include third-party data sources accessible to the content management network 100, but not maintained by the content management network 100.External data aggregators 309 may include any electronic information source relating to the users, content resources, or applications of the content distribution network 100.For example, external data aggregators 309 may be third-party data stores containing demographic data, education related data, consumer sales data, health related data, and the like.", "Illustrative external data aggregators 309 may include, for example, social networking web servers, public records data stores, learning management systems, educational institution servers, business servers, consumer sales data stores, medical record data stores, etc.", "Data retrieved from various external data aggregators 309 may be used to verify and update user account information, suggest user content, and perform user and content evaluations.", "With reference now to FIG.", "4, a block diagram is shown illustrating an embodiment of one or more content management servers 102 within a content distribution network 100.As discussed above, content management server(s) 102 may include various server hardware and software components that manage the content resources within the content distribution network 100 and provide interactive and adaptive content to users on various user devices 106.For example, content management server(s) 102 may provide instructions to and receive information from the other devices within the content distribution network 100, in order to manage and transmit content resources, user data, and server or client applications executing within the network 100.A content management server 102 may include a content customization system 402.The content customization system 402 may be implemented using dedicated hardware within the content distribution network 100 (e.g., a content customization server 402), or using designated hardware and software resources within a shared content management server 102.It will be appreciated that, though FIG.", "4 shows content management server 102 as including content customization system 402, user management system 404, evaluation system 406 and content delivery system 408, one or more of the systems (or corresponding or similar systems) may also or alternatively reside on a different device.", "For example, a user device (e.g., executing an executable file) and/or relay device may include an evaluation system, and/or a relay device may include a user management system 404 and/or content delivery system 408.In some embodiments, the content customization system 402 may adjust the selection and adaptive capabilities of content resources to match the needs and desires of the users receiving the content.", "For example, the content customization system 402 may query various data stores and servers 104 to retrieve user information, such as user preferences and characteristics (e.g., from a user profile data store 301), user access restrictions to content recourses (e.g., from a content access data store 306), previous user results and content evaluations (e.g., from an evaluation data store 308), and the like.", "Based on the retrieved information from data stores 104 and other data sources, the content customization system 402 may modify content resources for individual users.", "A content management server 102 also may include a user management system 404.The user management system 404 may be implemented using dedicated hardware within the content distribution network 100 (e.g., a user management server 404), or using designated hardware and software resources within a shared content management server 102.In some embodiments, the user management system 404 may monitor the progress of users through various types of content resources and groups, such as media compilations, courses or curriculums in training or educational contexts, interactive gaming environments, and the like.", "For example, the user management system 404 may query one or more databases and/or data store servers 104 to retrieve user data such as associated content compilations or programs, content completion status, user goals, results, and the like.", "A content management server 102 also may include an evaluation system 406.The evaluation system 406 may be implemented using dedicated hardware within the content distribution network 100 (e.g., an evaluation server 406), or using designated hardware and software resources within a shared content management server 102.The evaluation system 406 may be configured to receive and analyze information from user devices 106.For example, various ratings of content resources submitted by users may be compiled and analyzed, and then stored in a data store (e.g., a content library data store 303 and/or evaluation data store 308) associated with the content.", "In some embodiments, the evaluation server 406 may analyze the information to determine the effectiveness or appropriateness of content resources with, for example, a subject matter, an age group, a skill level, or the like.", "In some embodiments, the evaluation system 406 may provide updates to the content customization system 402 or the user management system 404, with the attributes of one or more content resources or groups of resources within the network 100.The evaluation system 406 also may receive and analyze user evaluation data from user devices 106, supervisor devices 110, and administrator servers 116, etc.", "For instance, evaluation system 406 may receive, aggregate, and analyze user evaluation data for different types of users (e.g., end users, supervisors, administrators, etc.)", "in different contexts (e.g., media consumer ratings, trainee or student comprehension levels, teacher effectiveness levels, gamer skill levels, etc.).", "A content management server 102 also may include a content delivery system 408.The content delivery system 408 may be implemented using dedicated hardware within the content distribution network 100 (e.g., a content delivery server 408), or using designated hardware and software resources within a shared content management server 102.The content delivery system 408 may receive content resources from the content customization system 402 and/or from the user management system 404, and provide the resources to user devices 106.The content delivery system 408 may determine the appropriate presentation format for the content resources based on the user characteristics and preferences, and/or the device capabilities of user devices 106.If needed, the content delivery system 408 may convert the content resources to the appropriate presentation format and/or compress the content before transmission.", "In some embodiments, the content delivery system 408 may also determine the appropriate transmission media and communication protocols for transmission of the content resources.", "In some embodiments, the content delivery system 408 may include specialized security and integration hardware 410, along with corresponding software components to implement the appropriate security features content transmission and storage, to provide the supported network and client access models, and to support the performance and scalability requirements of the network 100.The security and integration layer 410 may include some or all of the security and integration components 208 discussed above in FIG.", "2, and may control the transmission of content resources and other data, as well as the receipt of requests and content interactions, to and from the user devices 106, supervisor devices 110, administrative servers 116, and other devices in the network 100.With reference now to FIG.", "5, a block diagram of an illustrative computer system is shown.", "The system 500 may correspond to any of the computing devices or servers of the content distribution network 100 described above, or any other computing devices described herein.", "In this example, computer system 500 includes processing units 504 that communicate with a number of peripheral subsystems via a bus subsystem 502.These peripheral subsystems include, for example, a storage subsystem 510, an I/O subsystem 526, and a communications subsystem 532.Bus subsystem 502 provides a mechanism for letting the various components and subsystems of computer system 500 communicate with each other as intended.", "Although bus subsystem 502 is shown schematically as a single bus, alternative embodiments of the bus subsystem may utilize multiple buses.", "Bus subsystem 502 may be any of several types of bus structures including a memory bus or memory controller, a peripheral bus, and a local bus using any of a variety of bus architectures.", "Such architectures may include, for example, an Industry Standard Architecture (ISA) bus, Micro Channel Architecture (MCA) bus, Enhanced ISA (EISA) bus, Video Electronics Standards Association (VESA) local bus, and Peripheral Component Interconnect (PCI) bus, which can be implemented as a Mezzanine bus manufactured to the IEEE P1386.1 standard.", "Processing unit 504, which may be implemented as one or more integrated circuits (e.g., a conventional microprocessor or microcontroller), controls the operation of computer system 500.One or more processors, including single core and/or multicore processors, may be included in processing unit 504.As shown in the figure, processing unit 504 may be implemented as one or more independent processing units 506 and/or 508 with single or multicore processors and processor caches included in each processing unit.", "In other embodiments, processing unit 504 may also be implemented as a quad-core processing unit or larger multicore designs (e.g., hexa-core processors, octo-core processors, ten-core processors, or greater.", "Processing unit 504 may execute a variety of software processes embodied in program code, and may maintain multiple concurrently executing programs or processes.", "At any given time, some or all of the program code to be executed can be resident in processor(s) 504 and/or in storage subsystem 510.In some embodiments, computer system 500 may include one or more specialized processors, such as digital signal processors (DSPs), outboard processors, graphics processors, application-specific processors, and/or the like.", "I/O subsystem 526 may include device controllers 528 for one or more user interface input devices and/or user interface output devices 530.User interface input and output devices 530 may be integral with the computer system 500 (e.g., integrated audio/video systems, and/or touchscreen displays), or may be separate peripheral devices which are attachable/detachable from the computer system 500.Input devices 530 may include a keyboard, pointing devices such as a mouse or trackball, a touchpad or touch screen incorporated into a display, a scroll wheel, a click wheel, a dial, a button, a switch, a keypad, audio input devices with voice command recognition systems, microphones, and other types of input devices.", "Input devices 530 may also include three dimensional (3D) mice, joysticks or pointing sticks, gamepads and graphic tablets, and audio/visual devices such as speakers, digital cameras, digital camcorders, portable media players, webcams, image scanners, fingerprint scanners, barcode reader 3D scanners, 3D printers, laser rangefinders, and eye gaze tracking devices.", "Additional input devices 530 may include, for example, motion sensing and/or gesture recognition devices that enable users to control and interact with an input device through a natural user interface using gestures and spoken commands, eye gesture recognition devices that detect eye activity from users and transform the eye gestures as input into an input device, voice recognition sensing devices that enable users to interact with voice recognition systems through voice commands, medical imaging input devices, MIDI keyboards, digital musical instruments, and the like.", "Output devices 530 may include one or more display subsystems, indicator lights, or non-visual displays such as audio output devices, etc.", "Display subsystems may include, for example, cathode ray tube (CRT) displays, flat-panel devices, such as those using a liquid crystal display (LCD) or plasma display, projection devices, touch screens, and the like.", "In general, use of the term “output device” is intended to include all possible types of devices and mechanisms for outputting information from computer system 500 to a user or other computer.", "For example, output devices 530 may include, without limitation, a variety of display devices that visually convey text, graphics and audio/video information such as monitors, printers, speakers, headphones, automotive navigation systems, plotters, voice output devices, and modems.", "Computer system 500 may comprise one or more storage subsystems 510, comprising hardware and software components used for storing data and program instructions, such as system memory 518 and computer-readable storage media 516.The system memory 518 and/or computer-readable storage media 516 may store program instructions that are loadable and executable on processing units 504, as well as data generated during the execution of these programs.", "Depending on the configuration and type of computer system 500, system memory 318 may be stored in volatile memory (such as random access memory (RAM) 512) and/or in non-volatile storage drives 514 (such as read-only memory (ROM), flash memory, etc.)", "The RAM 512 may contain data and/or program modules that are immediately accessible to and/or presently being operated and executed by processing units 504.In some implementations, system memory 518 may include multiple different types of memory, such as static random access memory (SRAM) or dynamic random access memory (DRAM).", "In some implementations, a basic input/output system (BIOS), containing the basic routines that help to transfer information between elements within computer system 500, such as during start-up, may typically be stored in the non-volatile storage drives 514.By way of example, and not limitation, system memory 518 may include application programs 520, such as client applications, Web browsers, mid-tier applications, server applications, etc., program data 522, and an operating system 524.Storage subsystem 510 also may provide one or more tangible computer-readable storage media 516 for storing the basic programming and data constructs that provide the functionality of some embodiments.", "Software (programs, code modules, instructions) that when executed by a processor provide the functionality described herein may be stored in storage subsystem 510.These software modules or instructions may be executed by processing units 504.Storage subsystem 510 may also provide a repository for storing data used in accordance with the present invention.", "Storage subsystem 300 may also include a computer-readable storage media reader that can further be connected to computer-readable storage media 516.Together and, optionally, in combination with system memory 518, computer-readable storage media 516 may comprehensively represent remote, local, fixed, and/or removable storage devices plus storage media for temporarily and/or more permanently containing, storing, transmitting, and retrieving computer-readable information.", "Computer-readable storage media 516 containing program code, or portions of program code, may include any appropriate media known or used in the art, including storage media and communication media, such as but not limited to, volatile and non-volatile, removable and non-removable media implemented in any method or technology for storage and/or transmission of information.", "This can include tangible computer-readable storage media such as RAM, ROM, electronically erasable programmable ROM (EEPROM), flash memory or other memory technology, CD-ROM, digital versatile disk (DVD), or other optical storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices, or other tangible computer readable media.", "This can also include nontangible computer-readable media, such as data signals, data transmissions, or any other medium which can be used to transmit the desired information and which can be accessed by computer system 500.By way of example, computer-readable storage media 516 may include a hard disk drive that reads from or writes to non-removable, nonvolatile magnetic media, a magnetic disk drive that reads from or writes to a removable, nonvolatile magnetic disk, and an optical disk drive that reads from or writes to a removable, nonvolatile optical disk such as a CD ROM, DVD, and Blu-Ray® disk, or other optical media.", "Computer-readable storage media 516 may include, but is not limited to, Zip® drives, flash memory cards, universal serial bus (USB) flash drives, secure digital (SD) cards, DVD disks, digital video tape, and the like.", "Computer-readable storage media 516 may also include, solid-state drives (SSD) based on non-volatile memory such as flash-memory based SSDs, enterprise flash drives, solid state ROM, and the like, SSDs based on volatile memory such as solid state RAM, dynamic RAM, static RAM, DRAM-based SSDs, magnetoresistive RAM (MRAM) SSDs, and hybrid SSDs that use a combination of DRAM and flash memory based SSDs.", "The disk drives and their associated computer-readable media may provide non-volatile storage of computer-readable instructions, data structures, program modules, and other data for computer system 500.Communications subsystem 532 may provide a communication interface from computer system 500 and external computing devices via one or more communication networks, including local area networks (LANs), wide area networks (WANs) (e.g., the Internet), and various wireless telecommunications networks.", "As illustrated in FIG.", "5, the communications subsystem 532 may include, for example, one or more network interface controllers (NICs) 534, such as Ethernet cards, Asynchronous Transfer Mode NICs, Token Ring NICs, and the like, as well as one or more wireless communications interfaces 536, such as wireless network interface controllers (WNICs), wireless network adapters, and the like.", "Additionally and/or alternatively, the communications subsystem 532 may include one or more modems (telephone, satellite, cable, ISDN), synchronous or asynchronous digital subscriber line (DSL) units, FireWire® interfaces, USB® interfaces, and the like.", "Communications subsystem 536 also may include radio frequency (RF) transceiver components for accessing wireless voice and/or data networks (e.g., using cellular telephone technology, advanced data network technology, such as 3G, 4G or EDGE (enhanced data rates for global evolution), WiFi (IEEE 802.11 family standards, or other mobile communication technologies, or any combination thereof), global positioning system (GPS) receiver components, and/or other components.", "The various physical components of the communications subsystem 532 may be detachable components coupled to the computer system 500 via a computer network, a FireWire® bus, or the like, and/or may be physically integrated onto a motherboard of the computer system 500.Communications subsystem 532 also may be implemented in whole or in part by software.", "In some embodiments, communications subsystem 532 may also receive input communication in the form of structured and/or unstructured data feeds, event streams, event updates, and the like, on behalf of one or more users who may use or access computer system 500.For example, communications subsystem 532 may be configured to receive data feeds in real-time from users of social networks and/or other communication services, web feeds such as Rich Site Summary (RSS) feeds, and/or real-time updates from one or more third party information sources (e.g., data aggregators 309).", "Additionally, communications subsystem 532 may be configured to receive data in the form of continuous data streams, which may include event streams of real-time events and/or event updates (e.g., sensor data applications, financial tickers, network performance measuring tools, clickstream analysis tools, automobile traffic monitoring, etc.).", "Communications subsystem 532 may output such structured and/or unstructured data feeds, event streams, event updates, and the like to one or more data stores 104 that may be in communication with one or more streaming data source computers coupled to computer system 500.Due to the ever-changing nature of computers and networks, the description of computer system 500 depicted in the figure is intended only as a specific example.", "Many other configurations having more or fewer components than the system depicted in the figure are possible.", "For example, customized hardware might also be used and/or particular elements might be implemented in hardware, firmware, software, or a combination.", "Further, connection to other computing devices, such as network input/output devices, may be employed.", "Based on the disclosure and teachings provided herein, a person of ordinary skill in the art will appreciate other ways and/or methods to implement the various embodiments.", "Referring next to FIG.", "6, a block diagram of an embodiment of query management system 150 is shown.", "Query management system 150 can be, in part or in its entirety, in the cloud.", "In some instances, at least part of query management system 150 is present on a device, such as a user device 106 or a relay device.", "Query management system 150 can include a distributed system (e.g., part residing in content management server 102 and part on user device 106, part residing in the cloud and part on user device 106, part residing in content management server 102 and part on a relay device and part on user device 106, etc.).", "Further, it will be appreciated that each of one or more components of query management system 150 may reside on multiple devices.", "For example, each of a relay device and user device 106 may include an account engine 605 to verify an identity of a proctor and user, respectively, and each device may further include an interface engine 615 to receive inputs and present outputs.", "The operation of a given component may depend upon the type of device.", "Query management system 150 includes an account engine 605, which generates and maintains accounts for proctors and/or users and verifies identities of proctors (e.g., interacting with a relay device) and/or users.", "Account engine 605 can collect, e.g., personal (e.g., name, email address, residence address, telephone number and occupation), academic (e.g., grade level, current grade, school, one or more teachers, interests, course history, and course enrollment), and/or login (e.g., username and password) information.", "Account information can be stored in account data store 610.Further, account engine 605 can characterize a system-accessing party as a particular user or proctor (e.g., based on a login name or device identifier) and can verify an identity of the party by, e.g., ensuring that information entered by the party (e.g., login information) matches that in a stored account.", "Account engine 605 can interact with an interface engine 615 during account generation and/or account verification to receive account information, to identify an account and/or to receive information to allow for account access.", "A file retriever 620 can retrieve one or more executable files from a content management server 102 or relay device.", "In one instance, a power file that includes a set of executable files can be retrieved.", "The executable file(s) can be pushed from a sending device (content management server 102 or relay device) or pulled by a retrieving device (relay device or user device 106).", "The executable file(s) can be retrieved at a set time or when a condition is satisfied.", "For example, the executable file(s) can be retrieved when it is less than a threshold time before a start time and an a registered proctor or user is logged into a retrieving relay device or user device.", "As another example, the executable file(s) can be retrieved when input is provided that corresponds to a request to retrieve the executable file(s).", "After the executable file(s) are retrieved, file retriever 620 can decrypt and/or decompress the executable file(s).", "Such actions can be performed immediately or at a later time, such as prior to transmitting the files to another device or to executing a file.", "One or more executable files (or a power file including the executable files) can be stored in an executable-file data store 625.The executable files can be stored in association with a course identifier, a start time, and/or information indicating which devices or parties are allowed to access the files.", "In some instances, a file retriever 620 on a relay device initially retrieves one or more executable files (e.g., compressed into a power file) from a central server (e.g., content management server 102).", "This initial retrieval can be performed in advance of a start time.", "The executable files can then be cached in executable-file data store 625 on the relay device.", "a file retriever 620 on a user device can subsequently retrieve one or more executable files from the relay device.", "The subsequent retrieval can be performed at a start time or shortly before.", "This two-part retrieval technique can reduce a system load on a central server and can further reduce dependence on network connectivity.", "For example, user devices may be connected via a wired connection to a relay device, such that the second retrieval would not depend on a strength of a wireless connection.", "Access engine 630 can evaluate one or more conditions to determine whether an executable file can be retrieved, decrypted, decompressed, executed or otherwise accessed.", "Evaluation of the conditions can include evaluating a current time, an identified party (e.g., one logged into a device), an input (e.g., whether a party has interred input corresponding to a request to retrieve executable files or to begin can exam), etc.", "For example, access engine 630 can allow exam-file retrieval upon receiving input from a user corresponding to a request to retrieve the executable file and upon verifying that a current time is within a prescribed time window from a start time (e.g., a time at which an executable file is to be executed; a series of queries is to be presented and/or an examination is to begin or be presented).", "It will be appreciated that a condition applicable to executable file retrieval, decryption, decompression, or execution can differ from a condition applicable to another of these actions.", "An access engine 630 on a user device can identify one or more executable files to execute or read.", "This selection can be based on an analysis of software installed on a user device, hardware or resources on the user device or one or more applications open on the user device.", "For example, access engine 630 can identify a browser that is open on the user device or one that is identified as being a preferred browser for that device.", "Access engine 630 can then identify one or more executable files compatible with that browser.", "Upon detecting satisfaction and exam-initiation condition, access engine 630 can execute one or more executable files.", "The execution can cause the user device to be partly locked, such that the user's access to one or more applications is limited or blocked.", "The extent of such locking can be common across exams or can be determined based on an executable file variable (e.g., such that an instructor can identify applications that the user can access during the exam).", "The locking may extend to the same browser that the user is using to access the exam.", "Thus, for example, executable file questions may be presented in a tab in a browser, but the user may be prevented from opening a new tab or accessing Internet content using the browser.", "The prevention may occur by changing responses to traditional inputs (e.g., such that a control-T command has no effect, produces an error or pauses or ends in exam).", "Execution of one or more executable files can cause one or more executable file queries (or questions) to be presented on a user device via interface engine 615.In some instances, executable file questions can be presented on a screen of a user device using a browser that had been open prior to the executable file initiation.", "In some instances, the presentation can further include a set of potential responses or answers.", "In some instances, the presentation can include a text box where a user can enter a short answer or an essay response.", "In one instance, executable file questions are presented one at the time.", "Thus, for example, a second executable file question may be presented only once a response to a first executable file question has been received or a user has indicated that the first executable file question is to be skipped.", "In one instance, a set of executable file questions (e.g., all executable file questions) are simultaneously presented.", "When a presentation of the set of executable file questions extends beyond a viewable portion of a page (e.g., in a browser), a user may view individual executable file questions by scrolling through the page.", "Interface engine 615 can receive inputs from a user during an executable file period.", "The inputs can include text, a selection (e.g., between multiple answer options) or other inputs indicative of a response to an executable file question.", "In some instances, an input can further indicate whether a response is to be treated as final (e.g., a selection of a “submit” button).", "Such indication can be associated with a single response or a set of responses (e.g.", "multiple responses or all responses for an exam).", "In some instances, a response is determined to be final regardless of such explicit indication.", "A query response engine 635 can map response inputs to responses for particular questions.", "For example, query response engine 635 can determine that a particular response corresponds to a selection of answer choice D. As another example, query response engine 635 can determine that a particular response corresponds to a correct answer choice.", "As another example, query response engine 635 can associate a text response with question number 9.Query response engine 635 can generate a response file that includes response data for each response or for a set of responses (e.g., all responses for an executable file or subset thereof).", "The response file can include one or more of: an identifier of a corresponding user or user device, the time at which the response was received, an answer corresponding to the response, the response itself, an indication as to whether the response was correct, an application used to view a corresponding question or to provide the response and other information.", "The response file can be generated upon receiving one or more responses, prior to transmitting one or more responses, at an end time, prior to storing one or more responses (e.g., in long-term memory).", "The response file can be encrypted or otherwise securely stored.", "Query response engine 635 can store each response (e.g., by storing a response file) in query-response data store 640 and/or can transmit each response (e.g., by transmitting a response file) via query response transmitter 645 to a relay device or central server.", "The response may be stored in a locked or an unlocked configuration.", "Storing a response in locked configuration may include, for example, storing the response as read-only data (e.g., to a ROM chip), whereas storing a response in an unlocked configuration may include storing the response as read-write data (e.g., to a RAM chip).", "A locked configuration may further or alternatively be associated with a query-presentation configuration that restricts or prevents a corresponding query from being subsequently presented.", "A response may be stored in a locked configuration, for example, when a submission input (e.g., corresponding to a particular question, question set or exam) is received, a threshold number or at least a threshold number of responses have been identified (e.g., in total or since a previous response locking), a threshold time or at least a threshold time has passed (e.g., since a start time or a previous response locking), a query selection or customization has been performed based on the response and/or the response has been transmitted.", "The locking configuration can facilitate adaptive query generation.", "Responses can be transmitted individually or in sets.", "In some instances, whether responses are locally stored or how responses are stored (e.g., whether in short-term memory or long-term memory or whether the responses are stored in a locked configuration) depends on whether the responses are being or has been transmitted or whether transmission was successful.", "For example, responses may be stored in long-term memory only when responses of not been successfully transmitted to a relay device or central server.", "In some instances, a response is stored in an unlocked configuration and is also transmitted (e.g., to a relay device).", "If the response is later modified, the modified response may then be subsequently transmitted.", "In one instance, a transmission of one or more responses is attempted upon receipt of the responses or an indication that the responses of time.", "In one instance, the transmission is conditioned upon other circumstances.", "A condition can depend upon a connection availability or strength or other factors (e.g., a previous transmission success/failure, a processing load on a user device, etc.).", "A connection assessor 650 can identify a value of a connection variable (e.g., an availability of a connection or strength of a connection) and use this value to determine whether transmission should be attempted.", "The evaluation can include, for example, determining whether a user device is connected via a wired connection to another device, evaluating whether a wireless connection is available, evaluating a strength of a wireless connection, evaluating the success/failure of a test transmission or previous transmission (e.g., based on whether a success receipt confirmation was received from a receiving device), etc.", "In one instance, the value of the connection variable as compared to a threshold set forth in the transmission condition, such that the transmission is to be attempted when the value exceeds a threshold (e.g., a zero threshold, non-zero threshold or a threshold that is greater than one).", "Thus, for example, a handling of a first request may differ from a handling of a second request.", "To illustrate, a first request can be automatically transmitted to a relay device upon determining that a satisfactory wireless connection is available, while a second request can be stored instead of being transmitted upon determining that no satisfactory wireless connection is available.", "The conditioned transmission can lead to circumstances where responses are locally stored beyond the time at which they were finalized, beyond an end time (e.g., a time at which responses are no longer to be accepted, queries are no longer to be presented, a defined time or an end of a defined time period), etc.", "This may occur due to a previous failure to satisfy transmission condition or a previous transmission failure.", "Condition assessor 650 can then continue to monitor a connection variable and evaluate the transmission condition to determine when a transmission of the stored responses can be attempted.", "This subsequent evaluation can occur at a prescribed time interval from a past evaluation, at a prescribed time, upon receiving a request from a relay device or central server, etc.", "Once the condition is satisfied, query response transmitter 645 can attempt to transmit the responses (e.g., by transmitting a response file) to a relay device or central server.", "In some instances, query response transmitter 645 repeatedly attempts transmission (e.g., at fixed intervals) until all responses have been successfully transmitted.", "It will be appreciated that, in some instances, a number of responses actually transmitted are considered for transmission (e.g., based on the assessment performed by connection assessor 650) changes.", "Such as change can occur due to a change in speed at which a user provides responses, a previous transmission that was unsuccessful, a previous response or set of responses that was not transmitted (e.g., due to an unsatisfactory connection), etc.", "It will also be appreciated that a component of query management system 150 can be present on each of multiple types of devices (e.g., a relay device and a user device).", "The function of the component may be similar, the same or different depending on the device type.", "FIG.", "7 illustrates a flowchart of an embodiment of a process 700 for retrieving an power file at a user device.", "Part or all of process 700 can be implemented in a user device.", "Process 700 begins at block 705 where account engine 605 authenticates a user.", "The authentication can include, for example, matching one or more of the login name, a user name, a user device identifier, a user identifier, to data in a user account.", "The authentication can further verifying that additional information (e.g., a password or token) corresponds to data in the account or associated with the account.", "File retriever 620 identifies an executable file (e.g., which may be part of a power file) or identifies a power file for the user at block 710.For example, file retriever 620 can first identify one or more courses associated with a user's account or device location.", "A schedule associated with each of the one or more courses can be retrieved, and a current time can be mapped to each schedule.", "Thus, file retriever 620 can determine whether an exam (associated with a power file) is scheduled to occur for any of the one or more courses at a current time, a current day, within a defined time period, etc.", "In some instances, a user submits input response to a selection or other identification of a course, exam or file.", "File retriever 620 detects an initialization time at block 715.For each executable file, an initialization time or initialization time period can indicate a time at which or a time period during which executable file materials can be retrieved at a user device from a remote source.", "The initialization time or initialization time period may be defined for a given course for a given executable file (e.g., such that a proctor or instructor can at least partly define the initialization time or time period) or may be fixed across courses and/or exams.", "At block 715, file retriever 620 can detect whether a current time is subsequent to the initialization time or falls within the initialization time period.", "File retriever 620 securely retrieves an power file from a relay device (or central server) at block 720.For example, file retriever 620 can send a request to the relay device for the power file.", "The request can include an identifier of one or more of: the user device, the user, the course, the executable file (e.g., as determined using a schedule or account data), the power file and so on.", "A response to the request can then be received.", "In one instance, the power file includes a file that identifies one or more characteristics of other files to be included in the power file.", "For example, the file can identify a total number of files that are to be present in the power file, a version of each of one or more files in the power file, a size of each of one or more files in the power file (or a sum thereof), etc.", "A user device can then confirm that the appropriate files are received.", "For example, in one instance, the file identifies a version of each of one or more files to be present in the power file and/or a checksum thereof.", "The user device can then identify the versions of the received files, generate a checksum (e.g., according to an order prescribed in the file) and compare the generated checksum to that in the file.", "If it is determined that the files in the power file do not correspond to those that are to be included in the power file, an action may be taken, such as requesting the power file again or presenting a warning notification.", "A similar complete-transmission verification may be performed in association with a transmission of a power file from a central server to a relay device.", "The power file can include a set of (e.g., compressed) executable files.", "One or more files in the set of files can include executable files.", "In some instances, at least some files in the set of files differ in terms of their compatibility.", "For example, one or more first files may be compatible with a first browser or piece of software and one or more second files may be compatible with a second browser or piece of software.", "The power file and/or executable files in the power file can be encrypted or otherwise secured (e.g., password secured).", "The user device can identify a relay device (or central server) from which to retrieve or request the power file from based on, e.g., identifying a nearby relay device, identifying a relay device present on a wired connection, identifying a relay device in a same classroom, identifying a device associated with an identifier matching one associated with a course or executable file, etc.", "File retriever 620 decompresses the power file at block 725.The decompression can include unzipping the power file.", "The decompression can serve to convert a single power file into a set of separate executable files.", "In some instances, decompressing the power file includes decrypting the power file.", "In some instances, file retriever 620 further or alternatively decrypts or partially decrypts the power file and/or one or more executable files, or such decryption (if required) may be performed in advance or at a start time.", "Decrypting the file can include identifying, retrieving or generating a key.", "For example, a power file can include an instruction identifying a technique for generating a key.", "The technique may include a program code that retrieves or collects data of a particular type (e.g., user identifier, device identifier, location detected by a sensor, etc.)", "and using (e.g., transforming) the data into a key.", "The key can include a public key, a private key, and/or a symmetric key.", "In some instances, at least part of the key is initially generated at a central server and/or remote device (e.g., using a random number generator or pseudorandom number generator to generate a (pseudo)random number which can be combined with data identifiable at a user device and/or other data (e.g., a current data).", "At least part of the key (e.g., the (pseudo)random component thereof) can be transmitted from the central server or relay device to the user device.", "At block 730, file retriever 620 securely stores the executable files in executable-file data store 625.In some instances, file retriever 620 may encrypt or otherwise secure the executable files prior to storing them (e.g., in instances where executable files in the power file are not secure).", "In some instances, executable-file data store 625 as a whole a secure.", "The secure storage can serve to prevent a user or user device from accessing the executable files prior to a start time.", "In some instances, an initialization time insubstantial and the same as a start time.", "In such cases, block 730 can be omitted from process 700.It will be appreciated that, in some instances, executable files are not compressed at a relay device.", "Thus, in some instances, block 725 may be omitted from process 700.FIG.", "8 illustrates a flowchart of an embodiment of a process 800 for identifying and transmitting query responses.", "Part or all of process 800 can be implemented in a user device.", "Process 800 begins at block 805 where access engine 630 detects a start time.", "For each exam, a start time or start time period can indicate a time at which or a time period during which executable file materials can presented on a user device.", "The start time or start time period may be defined for a given course for a given executable file (e.g., such that a proctor or instructor can at least partly define the initialization time or time period) or may be fixed across courses and/or exams.", "In some instances, a start time or time period is determined based on a course time associated with a course.", "For example, for a 12 am course, a start time may be 12 am (on an executable file date).", "At block 805, access engine 630 can detect whether a current time is subsequent to the start time or falls within the start time period.", "In some instances, block 805 can further include detecting whether the user has provided an explicit request or implicit request (e.g., by logging into executable file software) to begin execution of an executable file.", "In some instances, block 805 further includes detecting whether one or more other execution-start conditions are satisfied, such as determining whether the user has completed a pre-executable file information form (e.g., identifying the user), determining whether executable file materials are locally available, determining whether the user completed one or more pre-requisites.", "Interface engine 615 presents executable file materials at block 810.The material can include a query.", "For example, access engine 630 can execute one or more executable files such that the executable file materials are presented.", "The executable file materials can include one or more queries (e.g., questions) and response (e.g., answer) opportunities (e.g., answer options, text boxes, labeling abilities, etc.).", "Presenting executable file materials can include presenting text, graphics, videos, audio streams, etc.", "Executable file materials can be simultaneously (e.g., in a single screen or page), sequentially or conditionally presented (e.g., such that a subset of executable file questions are presented at a time).", "Which particular question(s) are shown at a given time can depend on a question sequence, a user input (selecting a question or group of questions) and/or whether a previous response provided by the user was correct.", "Interface engine 615 identifies a query response at block 815.For example, a user may enter text, select a button option or other input option (e.g., an option on a drop-down menu, a slider value, a list option, etc.", "), click on a location on a screen (e.g., corresponding to a location in a graphic), etc.", "In some instances, the user response also includes input indicating that a response is complete, input indicating that a response is finalized, a request to progress to a next question, etc.", "Query response engine 635 can map the input received into response data.", "For example, a selection of an option can be mapped to a selection of a particular response.", "As another example, clicking on a screen location can be mapped to identifying a particular location within an image.", "As another example, entered text can be identified as a response.", "The response data can further associate the response with an identifier of one or more of: a question, a user, a user device, a response time, a course, an exam, and so on.", "At block 820, query response engine 635 securely stores the response data in query-response data store 640.Depending on the embodiment and/or circumstances, the response data may be locked such that the user is prevented from changing the stored response.", "Such locking can occur unconditionally, when an executable file or course variable indicates that such locking is to occur, when a user indicates that a response is final or is submitted, and so on.", "Thus, in some instances, a subset of responses for a given executable file and given user may be locked while others for the same executable file and user may not.", "Process 800 can return to block 815 such that additional responses can be received and stored.", "In some instances, process 800 returns to block 810 such that new executable file material (e.g., question(s)) can be presented.", "Access engine 630 detects an end time at block 825.An end time can indicate a time at which responses are to no longer be provided or modified (e.g., are locked), executable file materials are to no longer be presented on a user device and/or response data is to be transmitted from a user device to another device.", "The end time may be defined for a given course for a given executable file (e.g., such that a proctor or instructor can at least partly define the initialization time or time period) or may be fixed across courses and/or exams.", "In some instances, the end time depends on a start time (e.g., the end time being a fixed duration after a start time).", "In some instances, the end time is determined at least partly based on user input.", "For example, a user may identify that an executable file is complete, that responses are to be submitted, etc.", "Query response engine 635 locks at least one (or all) of the user's stored responses at block 830.The locking can be performed such that the user can no longer modify the responses or add responses.", "In some instances, the locking includes locking responses not already locked.", "Locking the response(s) can include storing the response(s) in a particular memory partition and/or memory type (e.g., ROM).", "Query response transmitter 645 securely transmits the stored response data at block 835.The responses can be transmitted to a relay device or central server.", "In some instances, response data identifying all responses for an executable file is transmitted in a single transmission (e.g., after an end time).", "In some instances, multiple transmissions are sent, with each including response data identifying various subsets of responses for an exam.", "For example, a transmission may occur or may be attempted (or a transmission condition may be evaluated) after each response is received, after each response is finalized, after each of a set of responses is received or finalized, etc.", "In one instance, the response data is encrypted prior to the transmission.", "The response data can be encrypted using a key used to decrypt a power file or executable file and/or one generated using a technique disclosed herein.", "Decrypting response data (e.g., or a file that includes the response data) using a key that is determined using (for example) an identifier of a user, user device, location, time, etc.", "Use of such a key can allow an evaluation to be performed to ensure, for example, that information accompanying the response data (e.g., in metadata) matches that of the key.", "For example, a relay device receiving metadata for response data can use a user name or device identifier included in the response data to generate a key.", "If the key cannot be used to decrypt the response data, it can suggest that a represented user did not provide a response in the response data.", "In some instances, whether a transmission is successful or whether it is attempted influences whether and/or how response data is saved.", "For example, when it is determined that a transmission will occur, will be attempted or was successful, a user device may forego saving the response data or may delete the stored response data.", "In some instances, response data can be transmitted to a destination device one or more times before the end time is detected at block 825.The destination device may be different than or the same as a device to which the response data is transmitted at block 835 (e.g., than a relay device).", "The destination device may include a storage server or device that may be located in a same room or building as the transmitting user device.", "Such intermediate transmission may serve to build back-up data, which may be used (for example) to reconstruct response data in response to a malfunction of or problem with a user device, relay device or network.", "In one instance, a transmission disclosed herein includes an FTP transmission, an SSH transmission and/or a tunneled transmission.", "In some instances, various types of transmissions may use different transmission techniques.", "For example, two or more of a transmission of a power file from a relay device to a user device, a transmission of response data to a storage server prior to an end time and a transmission of response data to a relay device at or after an end time may use a different transmission technique.", "FIG.", "9 illustrates a flowchart of an embodiment of a process 900 for conditionally transmitting query responses.", "Part or all of process 900 can be implemented in a user device.", "Process 900 begins at block 905 where access engine 630 detects an end time.", "Block 905 of process 900 can parallel block 825 of process 800.Connection assessor 650 assesses a connection at block 910.The assessment can include determining whether a connection (e.g., a wireless connection, a wired connection or either) to a network is available, whether a connection to a preferred network or to a network of a preferred type is available, determining a characteristic (e.g., upload or download speed, latency or network strength) of a network, determining whether the user device can communicate with a particular other device (e.g., a relay device or central server), determining how many networks are available, etc.", "A connection variable can be determined based on the assessment.", "For example, a connection variable can reflect a characteristic of a network (or a extremum of a characteristic across all available networks, such as a maximum strength, shortest latency or maximum upload speed), a number of networks available, a number of networks of a particular type or with a particular quality available, whether a preferred network is available, whether a wired connection is available, whether a local area network is available, whether a short-range network is available, and so on.", "Connection assessor 650 determines whether a connection condition is satisfied at block 915.The condition can require, for example, that a connection (e.g., a wireless connection, a wired connection or either) to a network be available, that a connection to a preferred network is available, that a connection to a network of a preferred type is available, that the user device can communicate with a particular other device, that a characteristic exceed a zero, non-zero or great-than-one threshold (a strength being above a threshold or a latency being below a threshold), etc.", "In one instance, the condition requires that a request for the responses be received from another device (e.g., a relay device) within a past particular time period.", "When it is determined that the condition is satisfied, process 900 continues to block 920 where query response transmitter 645 securely transmits response data (e.g., to a relay device).", "Block 920 of process 900 can parallel block 835 of process 800.When it is not determined that the condition is satisfied, process 900 can return to block 910, such that a connection can be repeatedly assessed and a condition repeatedly evaluated until all response data has been transmitted.", "In some instances, the return to block 910 is nearly immediate.", "In other instances, a delay is introduced.", "The delay may be, at least about, about, or less than about 1 second, 15 seconds, 70 seconds, 1 minute, 10 minutes, 70 minutes, 1 hour, 6 hours, 10 hours, 1 day or 6 days.", "This delay can serve to reduce repeated evaluations of same network conditions.", "In some instances, a quantity of untransmitted responses may build during iterations of the loop in process 900.It will be appreciated that response data may thus be aggregated for storing and/or for transmission.", "Thus, for example, rather than storing or transmitting multiple units (e.g., files or communications), each including non-response information (e.g., an identifier of a user, a user device, a course and/or an exam), a single unit can include one copy of the non-response information and aggregated response information.", "In some instances, process 900 further includes securely storing or caching the response data.", "The response data can be stored or cached regardless of whether it is determined that the condition is satisfied or not or can be stored only upon determining that the condition is not satisfied.", "The response data can be stored for a fixed time interval (e.g., one that is at least about 1 minute, 9 minutes, 10 minutes, 70 minutes, 1 hour, or 10 hours), until it is transmitted, until a receipt confirmation is received in response to transmission of the response data, until an available memory space drops below a threshold, until a memory space devoted to the response data and other response data crosses a threshold, and so on.", "While process 900 presents an embodiment where a transmission is conditioned based on a connection, it will be appreciated that other types of conditions can additionally or alternatively be used.", "For example, other conditions may relate to a time since a last transmission (e.g., requiring at least a threshold interval between transmissions), a success of a last transmission (e.g., requiring improved connection assessments following a previous transmission failure), whether an executable file period has ended (e.g., reducing or eliminating transmission conditions upon end of the executable file period), resources available on a user device (e.g., requiring that a resource level be above or below a threshold to attempt transmission), whether a request for responses has been received from a relay device, etc.", "In some instances, following a return to block 915, a same type of variable is assessed at block 910 as was previously assessed and/or a same condition is evaluated at block 915 as was previously evaluated.", "In some instances, a different type of variable is assessed upon a repeat of block 910 and/or a different condition is evaluated at block 915.For example, a threshold for a connection strength in a condition may be reduced following an end time.", "As another example, a condition may initially require a threshold resource availability on a user device (e.g., so as not to interrupt the exam) while the threshold may be reduced or the resource condition eliminated once the user completes the exam.", "As another exam, following repeated transmission failures, a condition may require receipt of a request for response data before attempting transmission again.", "While transmission of response data can be reserved for instances where an explicit condition is satisfied, it will be appreciated that transmission of response data can also or alternatively be functionally conditioned.", "For example, if no network is available to a user device or if a network connection is weak, transmission of the response data may not be possible.", "A functional condition can include instances where transmission attempts fail, where transmissions are not possible, where transmissions performed according to a transmission protocol (e.g., as set forth in an executable file and/or based on data from the user device) are not possible, and so on.", "FIG.", "10 illustrates a flowchart of an embodiment of a process 1000 for caching executable files.", "Part or all of process 1000 can be implemented in a relay device.", "Process 1000 begins at block 1005 where file retriever 620 identifies a structure.", "For example, a relay device can identify a classroom that the relay device is located in and can identify a structure (e.g., course) associated with that room (e.g., one having an executable file or time associated with that room generally or on a given day).", "As another example, a relay device may locally store structure information about one or more structures.", "As yet another example, a relay device may identify a structure based on information in a communication received from another device (e.g., from a central server).", "File retriever 620 securely retrieves an power file for the structure from a central server at block 1010.The retrieval can be performed on a day of an exam, a set time before a start time (e.g., a day or week before), at an initialization time, etc.", "In one instance, retrieving the power file includes sending a request for the power file to the central server.", "The request can include, for example, an identifier of the relay device, an identifier of a course, an identifier of an executable file and so on.", "In one instance, the power file is pushed from the central server without requiring a request.", "Along with the power file, the central server may provide information indicating when (e.g., an absolute or relative time or an absolute or relative time period) the power file is to be provided to user devices and/or which user devices are to allowed to retrieve the power file.", "File retriever 620 caches the power file in an executable-file data store resident on the relay device at block 1015.In some instances, file retriever 620 processes the power file to, e.g., decrypt, encrypt, secure or at least partly de-secure the power file.", "Access engine 630 identifies one or more user devices for the structure (e.g., course) at block 1020.This identification can be performed using information provided (along with the power file or separately) by the central server, by a device detection technique (e.g., detecting devices on a particular network, detecting devices in a room or detecting nearby devices), or by analyzing information received from other devices (e.g., determining whether an executable file code matches one for the power file, determining whether a user or device identifier matches one associated with the power file, etc.).", "Access engine 630 detects one or more initialization times at block 1025.Block 1025 can parallel block 715 of process 700.In some instances, receiving a request for a power file or receiving the power file from the central server can indicate that a current time qualifies as being an initialization time.", "A relay-device transmitter causes the power file to be transmitted to one or more user devices at block 1030.In some instances, the power file is pushed to one, some or all of the identified one or more user devices.", "In some instances, the power file is not transmitted to a user device in the identified one or more user devices until a request for the power file is first received.", "In instances where the power file is sent to multiple user devices, the power file may be sent to the devices simultaneously or at different times.", "A period between receipt of the power file and transmission of the power file (or processed version thereof), a period between receipt of the power file and a start time, a period between request for the power file and transmission of the power file (or processed version thereof), a period between request for the power file and a start time, and/or a period of caching of the power file may be at least about 1 minute, 9 minutes, 70 minutes, 1 hour, 10 hours, 12 hours, 1 day, 6 days or 1 week.", "By caching the power file in advance, a system load at a common executable file time can be reduced.", "In some instances, a schedule is developed across relay devices or exams such that a one of the above-listed time periods is varied across exams, relay devices, etc.", "Additionally or alternatively, the time period may depend at least in part on when a proctor input was received.", "In either case, a coordinated pre-executable file load may also be reduced.", "FIG.", "11 illustrates a flowchart of an embodiment of a process 1100 for caching query responses.", "Part or all of process 1100 can be implemented in a relay device.", "Process 1100 begins at block 1105 where a response receiver on a relay device receives a communication from a user device.", "The communication can include query response data, which can include a response and, in some instances, an identifier of one or more of: a user device, a user, a course, an executable file, a power file, an exam, a question, a response time and so on.", "Query response engine 635 encrypts or otherwise secures the response data at block 1110.In some instances, the received response data is already secure and/or encrypted, and no additional securing or encryption is performed.", "The response data can be encrypted using a key identified using a technique disclosed herein.", "For example, a key can include or can be generated using an identifier or a user or device.", "Query response engine 635 securely stores the response data at block 1115.Access engine 630 detects an executable file target transmission time at block 1120.The target transmission time can be identified based on data in an exam-related file, based on a communication received from a central server, based on input from a proctor (e.g., indicating that responses are to be submitted to the central server), based on a rule, etc.", "In one instance, a central server sends a request for responses to the relay device, and a time of receipt of the request can serve as the target transmission time.", "In some instances, the target transmission time is functionally determined (e.g., determined as being a time when responses are received from all user devices in a room, all user devices that received an executable file, etc.).", "Query response transmitter 645 securely transmits response data to a central server at block 1125.In some instances, all response data associated with an executable file is transmitted in a single transmission or communication and/or substantially concurrently.", "In some instances, multiple transmissions with response data are sent.", "For example, response data for one user device or a set of user devices can be transmitted as soon as it is received.", "The transmission at block 1125 can be conditioned.", "The condition may depend on, e.g., a load on a central server, whether a response-data request has been received from a central server, a quantity of response data received, an end time, a network strength, a network availability, a resource load or availability on a relay device, etc.", "FIG.", "12 illustrates a flowchart of an embodiment of a process 1200 for executing an executable file.", "Part or all of process 1200 can be implemented in a user device.", "Process 1200 begins at block 1205 where file retriever 620 identifies an open browser (e.g., as being Explorer®, Chrome®, Firefox® or Safari®).", "In instances where multiple browsers are open, file retriever 620 can identify a browser most recently opened, a browser which most recently was interacted with, a browser front-most on a screen, and so on.", "File retriever 620 identifies one or more executable files from an power file that are compatible with the open browser at block 1210.The identification can be compared by detecting metadata indicating compatibilities of files, by analyzing content of files, by evaluating a rule, by analyzing a function or file name, by analyzing an if function, and so on.", "In some instances, block 1210 includes identifying one or more parts of executable files that are compatible with the open browser.", "Access engine 630 detects a start time at block 1215.Block 1215 of process 1200 can correspond to block 805 of process 800.At block 1220, access engine 630 executes at least one of the one or more executable files (or parts of the file) such that one or more queries are presented in the open browser.", "Thus, for example, if a user opens an Explorer® browser, executable file queries or questions can be presented in the Explorer® browser, and executable file responses can be received via the Explorer® browser.", "It will be appreciated that one or more other executable files (or parts of executable files) may not have browser compatibility restrictions and can be executed at block 1220 regardless of the browser identified at block 1205.Via execution of the at least one executable files or of other files, access engine 630 restricts access to non-browser programs at block 1225.The extent of the restriction can be determined based on an exam, a course, a user device, and so on.", "For example, an instructor may indicate that users are allowed to access the Internet and Microsoft Word® during a test but no other applications.", "The central server can then generate or modify one or more executable files to enforce this restriction.", "An attempt to access a restricted application may result in a lack of traditional response, an error, or a negative executable file occurrence (e.g., ending a file execution).", "Interface engine 615 receives user input via the browser at block 1230.For example, a user may enter text, select a button option or other input option (e.g., an option on a drop-down menu, a slider value, a list option, etc.", "), click on a location on a screen (e.g., corresponding to a location in a graphic), etc.", "In some instances, the user response also includes input indicating that a response is complete, input indicating that a response is finalized, a request to progress to a next query, etc.", "Query response engine 635 determines a query response based on the input at block 1235.The determination may include mapping the input to response data.", "For example, a selection of an option can be mapped to a selection of a particular response.", "As another example, clicking on a screen location can be mapped to identifying a particular location within an image.", "As another example, entered text can be identified as a response.", "The response data can further associate the response with an identifier of one or more of: a question, a user, a user device, a response time, a course, an exam, and so on.", "FIG.", "13 illustrates a flowchart of an embodiment of a process 1300 for updating query response data based on conflict-resolution indications.", "Part of process 1200 can be implemented in a user device, such as user device 106.Part of process 1200 can be performed in a query management system, which can include (for example) a content management server 102, relay device, or other server or system (e.g., located remotely or in a same building or room as the user device).", "Process 1300 begins at block 1305 where the user device executes one or more executable files, which can facilitate a local presentation of each of one or more questions or queries.", "At block 1310, a query response for each of the one or more queries is determined (e.g., based on provided input).", "At block 1315a, response data that includes the query response(s) and potentially additional information (e.g., an identifier of an account, user, user device, and/or corresponding queries) is transmitted to the query management system.", "The response data is received at the query management system at block 1315b and stored in association with an identifier of an account, user, user device and/or time (e.g., of receipt of the response data or a time identified in the response data).", "Each of one or more of blocks 1305-1320 can correspond to similar actions disclosed herein.", "At block 1325, previous response data associated with a same user identifier or account identifier is retrieved (e.g., from a local storage or by sending a data request to a remote storage server).", "The previous response data can include identifiers of responses provided for a same executable file, exam, power file and/or date as that associated with the response data.", "In some instances, the previous response data and the response data were transmitted from different user devices.", "Depending on the embodiment, block 1325 is conditionally performed.", "For example, block 1325 may be performed when the response data or a corresponding communication includes a request for the previous response data.", "In some instances, each of the response data and the previous response data include a (same or different) response to a same query.", "In some alternative or same instances, each of the response data and the previous response data include a response to a different query.", "At block 1330a, at least part of the previous response data is transmitted to the user device, which is received at the user device at block 1330b.", "In one instance, each response in the previous response data is transmitted.", "In one instance, each query for which a response is included in each of the response data and the previous response data are identified, and the previous-response-data responses for each of those queries are included in the transmission.", "In one instance, each query for which different responses included in each of the response data and the previous response data are identified, and the previous-response-data responses for each of those queries are included in the transmission.", "In some instances, transmission of the at least part of the previous response data is conditioned.", "For example, block 1330a may be performed only when the previous response data and the response data include at least one conflicting response and/or if the previous response data includes a response not provided in the response data.", "The transmission may also include other information, such as identifiers of queries for which no response conflict was detected.", "At block 1335, the at least part of the previous response data is presented (e.g., at a single time or at multiple times).", "The presentation can include, for example, presenting an identifier of a query or a query itself along with a response as identified in the previous response data.", "The presentation may further include an identifier of a response as identified in the response data.", "When the responses from the previous response data and the response data conflict, the presentation can include a conflict-resolution option.", "For example, the conflict-resolution option can allow a user to select one of the two options.", "At block 1340, updated response data is identified based on a conflict-resolution indication.", "The conflict-resolution indication can be provided via interaction with the conflict-resolution option.", "For example, the conflict-resolution indication can identify a selected response for a particular query.", "The updated response data can include a selection between conflicting responses (or a response selection in general) for each of one or more queries, an identification of each of the one or more queries and/or an identifier of a user, user device, account and/or time.", "At block 1345a, the update response data is transmitted from the user device to the query management system, and the query management system receives the updated response data at block 1345b.", "The updated response data is stored at block 1350.Storing the updated response data can include, for example, deleting an unselected response, changing a status (e.g., to final or selected) of a response, committing a response to a particular memory or memory partition or storing a new data segment.", "Process 1300 thus provides a technique for detecting and to responding to conflicting data.", "Such data may be provided from different devices and may be a result of experience of a device or network problem during initial execution of a file.", "Process 1300 allows an executable file to initiate and run without needing to first retrieve response data, and yet normal response transmission can trigger a technique for detecting and responding to data conflicts.", "Embodiments herein provide a variety of technical advantages.", "For example, the inclusion of relay devices in networks can allow traffic involving a central server to be distributed in time so as to reduce peak loads.", "Proximity between relay devices and user devices enable the devices to communicate over short-range or wired connections to further reduce network demands during high-use time periods.", "Encryption techniques using device-specific keys can serve to verify that a source of a response is as is identified in metadata or input.", "Use of power files and browser-detection techniques can allow consistent content to be provided across browser types and to allow users to use familiar controls.", "Conditioned transmission of response data can reduce network demand to avoid repeated network use in ineffective connection attempts.", "Use of differential locking and unlocking configurations when storing responses can allow for adaptation in content and queries while still permitting acceptable levels of modification that would not disrupt the adaptation processes.", "A number of variations and modifications of the disclosed embodiments can also be used.", "Specific details are given in the above description to provide a thorough understanding of the embodiments.", "However, it is understood that the embodiments may be practiced without these specific details.", "For example, well-known circuits, processes, algorithms, structures, and techniques may be shown without unnecessary detail in order to avoid obscuring the embodiments.", "Implementation of the techniques, blocks, steps and means described above may be done in various ways.", "For example, these techniques, blocks, steps and means may be implemented in hardware, software, or a combination thereof.", "For a hardware implementation, the processing units may be implemented within one or more application specific integrated circuits (ASICs), digital signal processors (DSPs), digital signal processing devices (DSPDs), programmable logic devices (PLDs), field programmable gate arrays (FPGAs), processors, controllers, micro-controllers, microprocessors, other electronic units designed to perform the functions described above, and/or a combination thereof.", "Also, it is noted that the embodiments may be described as a process which is depicted as a flowchart, a flow diagram, a swim diagram, a data flow diagram, a structure diagram, or a block diagram.", "Although a depiction may describe the operations as a sequential process, many of the operations can be performed in parallel or concurrently.", "In addition, the order of the operations may be re-arranged.", "A process is terminated when its operations are completed, but could have additional steps not included in the figure.", "A process may correspond to a method, a function, a procedure, a subroutine, a subprogram, etc.", "When a process corresponds to a function, its termination corresponds to a return of the function to the calling function or the main function.", "Furthermore, embodiments may be implemented by hardware, software, scripting languages, firmware, middleware, microcode, hardware description languages, and/or any combination thereof.", "When implemented in software, firmware, middleware, scripting language, and/or microcode, the program code or code segments to perform the necessary tasks may be stored in a machine readable medium such as a storage medium.", "A code segment or machine-executable instruction may represent a procedure, a function, a subprogram, a program, a routine, a subroutine, a module, a software package, a script, a class, or any combination of instructions, data structures, and/or program statements.", "A code segment may be coupled to another code segment or a hardware circuit by passing and/or receiving information, data, arguments, parameters, and/or memory contents.", "Information, arguments, parameters, data, etc.", "may be passed, forwarded, or transmitted via any suitable means including memory sharing, message passing, token passing, network transmission, etc.", "For a firmware and/or software implementation, the methodologies may be implemented with modules (e.g., procedures, functions, and so on) that perform the functions described herein.", "Any machine-readable medium tangibly embodying instructions may be used in implementing the methodologies described herein.", "For example, software codes may be stored in a memory.", "Memory may be implemented within the processor or external to the processor.", "As used herein the term “memory” refers to any type of long term, short term, volatile, nonvolatile, or other storage medium and is not to be limited to any particular type of memory or number of memories, or type of media upon which memory is stored.", "Moreover, as disclosed herein, the term “storage medium” may represent one or more memories for storing data, including read only memory (ROM), random access memory (RAM), magnetic RAM, core memory, magnetic disk storage mediums, optical storage mediums, flash memory devices and/or other machine readable mediums for storing information.", "The term “machine-readable medium” includes, but is not limited to portable or fixed storage devices, optical storage devices, and/or various other storage mediums capable of storing that contain or carry instruction(s) and/or data.", "While the principles of the disclosure have been described above in connection with specific apparatuses and methods, it is to be clearly understood that this description is made only by way of example and not as limitation on the scope of the disclosure." ] ]
Patent_15874244
[ [ "DISPLAY DEVICE AND ELECTRONIC DEVICE INCLUDING THE SAME", "It is an object to decrease the number of transistors connected to a capacitor.", "In a structure, a capacitor and one transistor are included, one electrode of the capacitor is connected to a wiring, and the other electrode of the capacitor is connected to a gate of the transistor.", "Since a clock signal is input to the wiring, the clock signal is input to the gate of the transistor through the capacitor.", "Then, on/off of the transistor is controlled by a signal which synchronizes with the clock signal, so that a period when the transistor is on and a period when the transistor is off are repeated.", "In this manner, deterioration of the transistor can be suppressed." ], [ "1.A semiconductor device comprising a gate driver, wherein the gate driver comprises a first transistor, a second transistor, and a third transistor, wherein the first transistor comprises a first gate electrode, a first semiconductor layer above the first gate electrode, a first source electrode above the first semiconductor layer, and a first drain electrode above the first semiconductor layer, wherein the second transistor comprises a second gate electrode, a second semiconductor layer above the second gate electrode, a second source electrode above the second semiconductor layer, and a second drain electrode above the second semiconductor layer, wherein the third transistor comprises a third gate electrode, a third semiconductor layer above the third gate electrode, a third source electrode above the third semiconductor layer, and a third drain electrode above the third semiconductor layer, wherein one of the first source electrode and the first drain electrode is electrically connected to a clock signal line, wherein one of the second source electrode and the second drain electrode is electrically connected to a power supply line, wherein one of the third source electrode and the third drain electrode is electrically connected to the power supply line, wherein the other of the first source electrode and the first drain electrode is electrically connected to a gate signal line, wherein the other of the second source electrode and the second drain electrode is electrically connected to the gate signal line, wherein the other of the third source electrode and the third drain electrode is electrically connected to the gate signal line, wherein, in the first transistor, an area where the other of the first source electrode and the first drain electrode overlaps with the first gate electrode is larger than an area where the one of the first source electrode and the first drain electrode overlaps with the first gate electrode, wherein, in the second transistor, an area where the other of the second source electrode and the second drain electrode overlaps with the second gate electrode is smaller than an area where the one of the second source electrode and the second drain electrode overlaps with the second gate electrode, and wherein, in the third transistor, an area where the other of the third source electrode and the third drain electrode overlaps with the third gate electrode is smaller than an area where the one of the third source electrode and the third drain electrode overlaps with the third gate electrode.", "2.A semiconductor device comprising a gate driver, wherein the gate driver comprises a first transistor, a second transistor, and a third transistor, wherein the first transistor comprises a first gate electrode, a first semiconductor layer above the first gate electrode, a first source electrode above the first semiconductor layer, and a first drain electrode above the first semiconductor layer, wherein the second transistor comprises a second gate electrode, a second semiconductor layer above the second gate electrode, a second source electrode above the second semiconductor layer, and a second drain electrode above the second semiconductor layer, wherein the third transistor comprises a third gate electrode, a third semiconductor layer above the third gate electrode, a third source electrode above the third semiconductor layer, and a third drain electrode above the third semiconductor layer, wherein one of the first source electrode and the first drain electrode is electrically connected to a clock signal line, wherein one of the second source electrode and the second drain electrode is electrically connected to a power supply line, wherein one of the third source electrode and the third drain electrode is electrically connected to the power supply line, wherein the other of the first source electrode and the first drain electrode is electrically connected to a first gate signal line, wherein the other of the second source electrode and the second drain electrode is electrically connected to the first gate signal line, wherein the other of the third source electrode and the third drain electrode is electrically connected to the first gate signal line, wherein the third gate electrode is electrically connected to a second gate signal line, wherein, in the first transistor, an area where the other of the first source electrode and the first drain electrode overlaps with the first gate electrode is larger than an area where the one of the first source electrode and the first drain electrode overlaps with the first gate electrode, wherein, in the second transistor, an area where the other of the second source electrode and the second drain electrode overlaps with the second gate electrode is smaller than an area where the one of the second source electrode and the second drain electrode overlaps with the second gate electrode, and wherein, in the third transistor, an area where the other of the third source electrode and the third drain electrode overlaps with the third gate electrode is smaller than an area where the one of the third source electrode and the third drain electrode overlaps with the third gate electrode.", "3.A semiconductor device comprising a gate driver, wherein the gate driver comprises a first transistor, a second transistor, a third transistor, and a fourth transistor, wherein the first transistor comprises a first gate electrode, a first semiconductor layer above the first gate electrode, a first source electrode above the first semiconductor layer, and a first drain electrode above the first semiconductor layer, wherein the second transistor comprises a second gate electrode, a second semiconductor layer above the second gate electrode, a second source electrode above the second semiconductor layer, and a second drain electrode above the second semiconductor layer, wherein the third transistor comprises a third gate electrode, a third semiconductor layer above the third gate electrode, a third source electrode above the third semiconductor layer, and a third drain electrode above the third semiconductor layer, wherein the fourth transistor comprises a fourth gate electrode, a fourth semiconductor layer above the fourth gate electrode, a fourth source electrode above the fourth semiconductor layer, and a fourth drain electrode above the fourth semiconductor layer, wherein one of the first source electrode and the first drain electrode is electrically connected to a clock signal line, wherein one of the second source electrode and the second drain electrode is electrically connected to a power supply line, wherein one of the third source electrode and the third drain electrode is electrically connected to the power supply line, wherein one of the fourth source electrode and the fourth drain electrode is electrically connected to the power supply line, wherein the other of the first source electrode and the first drain electrode is electrically connected to a gate signal line, wherein the other of the second source electrode and the second drain electrode is electrically connected to the gate signal line, wherein the other of the third source electrode and the third drain electrode is electrically connected to the gate signal line, wherein the other of the fourth source electrode and the fourth drain electrode is electrically connected to the first gate electrode, wherein, in the first transistor, an area where the other of the first source electrode and the first drain electrode overlaps with the first gate electrode is larger than an area where the one of the first source electrode and the first drain electrode overlaps with the first gate electrode, wherein, in the second transistor, an area where the other of the second source electrode and the second drain electrode overlaps with the second gate electrode is smaller than an area where the one of the second source electrode and the second drain electrode overlaps with the second gate electrode, wherein, in the third transistor, an area where the other of the third source electrode and the third drain electrode overlaps with the third gate electrode is smaller than an area where the one of the third source electrode and the third drain electrode overlaps with the third gate electrode, and wherein, in the fourth transistor, an area where the other of the fourth source electrode and the fourth drain electrode overlaps with the fourth gate electrode is smaller than an area where the one of the fourth source electrode and the fourth drain electrode overlaps with the fourth gate electrode." ], [ "<SOH> BACKGROUND ART <EOH>In recent years, with the increase of large display devices such as liquid crystal televisions, display devices have been actively developed.", "In specific, a technique of forming a driver circuit such as a gate driver over the same substrate as a pixel portion by using a transistor formed using a non-single-crystal semiconductor has been actively developed because the technique makes a great contribution for reduction in cost and improvement in reliability.", "However, deterioration such as increase in threshold voltage or decrease in mobility is caused in the transistor formed using the non-single-crystal semiconductor.", "As the deterioration of the transistor advances, there is a problem in that the driver circuit becomes hard to operate and an image cannot be displayed.", "Accordingly, Patent Document 1 discloses a structure of a shift register which can suppress the deterioration of the transistor.", "In Patent Document 1, one electrode of a capacitor is connected to a wiring to which a clock signal is input and the other electrode of the capacitor is connected to gates of two transistors, so that the potential of the other electrode of the capacitor is increased or decreased by making the potential synchronize with the clock signal.", "In this manner, by utilizing capacitive coupling of the capacitor, signals that synchronize with the clock signal are generated in the gates of the two transistors.", "Then, by using the signals that synchronize with the clock signal, on and off of the transistors is controlled.", "Accordingly, since a period when the transistor is on and a period when the transistor is off are repeated, the deterioration of the transistors can be suppressed." ], [ "<SOH> BRIEF DESCRIPTION OF DRAWINGS <EOH>FIG.", "1A is a circuit diagram of a semiconductor device and FIG.", "1B is a timing chart for illustrating a driving method of the semiconductor device.", "FIGS.", "2A to 2E are schematic views illustrating a driving method of a semiconductor device.", "FIGS.", "3A to 3E are circuit diagrams of a semiconductor device.", "FIGS.", "4A to 4F are circuit diagrams of a semiconductor device.", "FIGS.", "5A to 5E are circuit diagrams of a semiconductor device.", "FIG.", "6A is a circuit diagram of a semiconductor device and FIGS.", "6B and 6C are timing charts each illustrating a driving method of the semiconductor device.", "FIGS.", "7A to 7C are schematic views illustrating a driving method of a semiconductor device.", "FIGS.", "8A and 8B are schematic views illustrating a driving method of a semiconductor device.", "FIGS.", "9A to 9C are circuit diagrams of a semiconductor device.", "FIGS.", "10A to 10C are circuit diagrams of a semiconductor device.", "FIGS.", "11A to 11C are circuit diagrams of a semiconductor device.", "FIGS.", "12A to 12C are circuit diagrams of a semiconductor device.", "FIGS.", "13A to 13C are circuit diagrams of a semiconductor device.", "FIG.", "14A is a circuit diagram of a shift register and FIG.", "14B is a timing chart illustrating a driving method of the shift register.", "FIG.", "15 is a circuit diagram of a shift register.", "FIG.", "16 is a circuit diagram of a shift register.", "FIGS.", "17A and 17B are circuit diagrams of a shift register.", "FIG.", "18 is a layout view of a shift register.", "FIG.", "19A is a circuit diagram of a semiconductor device and FIG.", "19B is a timing chart illustrating a driving method of the semiconductor device.", "FIGS.", "20A and 20B are circuit diagrams of a semiconductor device.", "FIG.", "21 is a circuit diagram of a shift register.", "FIGS.", "22A and 22B are system block diagrams of a display device.", "FIGS.", "23A to 23E are diagrams each illustrating a structure of a display device.", "FIG.", "24 is a circuit diagram of a shift register.", "FIGS.", "25A and 25B are timing charts each illustrating a driving method of a shift register.", "FIG.", "26A is a circuit diagram of a signal line driver circuit and FIG.", "26B is a timing chart illustrating a driving method of the signal line driver circuit.", "FIGS.", "27A to 27C, 27E, and 27F are circuit diagrams of a pixel and FIGS.", "27D and 27G are timing charts each illustrating a driving method of the pixel.", "FIGS.", "28A and 28B are circuit diagrams of a pixel, FIGS.", "28C to 28E and 28G are layout diagrams of the pixel, and FIGS.", "28F and 28H are timing charts each illustrating a driving method of the pixel.", "FIG.", "29A is a timing chart illustrating a driving method of a pixel and FIG.", "29B is a circuit diagram of the pixel.", "FIG.", "30 is a layout view of a shift register.", "FIG.", "31 is a layout view of a shift register.", "FIGS.", "32A to 32C are cross-sectional views of a transistor.", "FIGS.", "33A to 33H are diagrams illustrating electronic devices.", "FIGS.", "34A to 34H are diagrams illustrating electronic devices.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "15/145,908, filed May 4, 2016, now allowed, which is a continuation of U.S. application Ser.", "No.", "14/552,547, filed Nov. 25, 2014, now U.S. Pat.", "No.", "9,337,184, which is a continuation of U.S. application Ser.", "No.", "13/769,999, filed Feb. 19, 2013, now U.S. Pat.", "No.", "8,902,374, which is a continuation of U.S. application Ser.", "No.", "12/614,852, filed Nov. 9, 2009, now U.S. Pat.", "No.", "8,902,144, which claims the benefit of a foreign priority application filed in Japan as Serial No.", "2008-304124 on Nov. 28, 2008, all of which are incorporated by reference.", "TECHNICAL FIELD The present invention relates to a semiconductor device, a display device, a liquid crystal display device, a driving method thereof, or a producing method thereof.", "In specific, the present invention relates to a semiconductor device, a display device, or a liquid crystal display device including a driver circuit formed over the same substrate as a pixel portion, or a driving method of the device.", "Alternatively, the present invention relates to an electronic device including the device.", "BACKGROUND ART In recent years, with the increase of large display devices such as liquid crystal televisions, display devices have been actively developed.", "In specific, a technique of forming a driver circuit such as a gate driver over the same substrate as a pixel portion by using a transistor formed using a non-single-crystal semiconductor has been actively developed because the technique makes a great contribution for reduction in cost and improvement in reliability.", "However, deterioration such as increase in threshold voltage or decrease in mobility is caused in the transistor formed using the non-single-crystal semiconductor.", "As the deterioration of the transistor advances, there is a problem in that the driver circuit becomes hard to operate and an image cannot be displayed.", "Accordingly, Patent Document 1 discloses a structure of a shift register which can suppress the deterioration of the transistor.", "In Patent Document 1, one electrode of a capacitor is connected to a wiring to which a clock signal is input and the other electrode of the capacitor is connected to gates of two transistors, so that the potential of the other electrode of the capacitor is increased or decreased by making the potential synchronize with the clock signal.", "In this manner, by utilizing capacitive coupling of the capacitor, signals that synchronize with the clock signal are generated in the gates of the two transistors.", "Then, by using the signals that synchronize with the clock signal, on and off of the transistors is controlled.", "Accordingly, since a period when the transistor is on and a period when the transistor is off are repeated, the deterioration of the transistors can be suppressed.", "REFERENCE [Patent Document 1] Japanese Published Patent Application No.", "2006-24350 However, in Patent Document 1, since the other electrode of the capacitor is connected to the gates of the two transistors, there is a problem in that the parasitic capacitance of a node connected to the capacitor is high.", "Accordingly, there is a problem in that the potential in an H level of a signal that synchronizes with a clock signal becomes low.", "In that case, there is a problem in that a time during which a transistor can be turned is shortened if the threshold voltage of the transistor increases.", "That is, there is a problem in that the life of a shift register is shortened.", "Alternatively, since the parasitic capacitance of the node connected to the capacitor is high, there is a problem in that the capacitance value of the capacitor should be large.", "Accordingly, since an area where the one electrode of the capacitor and the other electrode of the capacitor overlap with each other needs to be large, there is a problem in that the layout area of the capacitor becomes large.", "In Patent Document 1, since the area of the capacitor needs to be large, there is a problem in that short circuit between the one electrode and the other electrode tends to be caused due to dust or the like.", "As a result, there is a problem in that yield is decreased and cost is increased.", "In Patent Document 1, since the capacitance value of the capacitor needs to be large, there is a problem in that delay or distortion of a signal (e.g., a clock signal or an inverted clock signal) supplied to the capacitor becomes obvious.", "Alternatively, there is a problem in that power consumption is increased.", "Since a circuit having high current driving capability is used as a circuit for outputting a signal to be supplied to the capacitor, there is a problem in that an outside circuit (hereinafter also referred to as an external circuit) becomes large.", "Alternatively, there is a problem in that a display device becomes large.", "In Patent Document 1, a period when a gate of a pull-up transistor Tu is in a floating state exists.", "Accordingly, noise or the like is caused because the potential of the gate of the pull-up transistor Tu is not stable.", "Therefore, there is a problem in that the shift register malfunctions.", "In view of the foregoing problems, it is an object to decrease the number of transistors connected to a capacitor.", "Alternatively, it is an object to decrease the parasitic capacitance of a transistor connected to the capacitor.", "Alternatively, it is an object to increase the potential in an H level of a signal which synchronizes with a clock signal.", "Alternatively, it is an object to decrease a layout area.", "Alternatively, it is an object to extend life.", "Alternatively, it is an object to decrease delay or distortion of a signal.", "Alternatively, it is an object to reduce power consumption.", "Alternatively, it is an object to decrease the adverse effect of noise.", "Alternatively, it is an object to suppress or relieve deterioration of a transistor.", "Alternatively, it is an object to suppress malfunction.", "Alternatively, it is an object to prevent short circuit between one electrode of a capacitor and the other electrode of the capacitor.", "Alternatively, it is an object to decrease the current driving capability of an outside circuit.", "Alternatively, it is an object to reduce the size of an outside circuit.", "Alternatively, it is an object to reduce the size of a display device.", "Note that the descriptions of these problems do not disturb the existence of other problems.", "DISCLOSURE OF INVENTION In a structure, a capacitor and one transistor are included, one electrode of the capacitor is connected to a wiring, and the other electrode of the capacitor is connected to a gate of the transistor.", "Since a clock signal is input to the wiring, the clock signal is input to the gate of the transistor through the capacitor.", "Then, on/off of the transistor is controlled by a signal which synchronizes with the clock signal, so that a period when the transistor is on and a period when the transistor is off are repeated.", "In this manner, deterioration of the transistor can be suppressed.", "According to one exemplary embodiment of the present invention, a liquid crystal display device includes a driver circuit and a pixel.", "The pixel includes a liquid crystal element.", "The driver circuit includes a first transistor, a second transistor, a third transistor, a fourth transistor, and a capacitor.", "A first terminal of the first transistor is electrically connected to a first wiring.", "A second terminal of the first transistor is electrically connected to a second wiring.", "A first terminal of the second transistor is electrically connected to the second wiring.", "A second terminal of the second transistor is electrically connected to a gate of the first transistor.", "A gate of the second transistor is electrically connected to the first wiring.", "A first terminal of the third transistor is electrically connected to a third wiring.", "A second terminal of the third transistor is electrically connected to the gate of the first transistor.", "A first terminal of the fourth transistor is electrically connected to the third wiring.", "A second terminal of the fourth transistor is electrically connected to a gate of the third transistor.", "A gate of the fourth transistor is electrically connected to the gate of the first transistor.", "One electrode of the capacitor is electrically connected to the first wiring.", "The other electrode of the capacitor is electrically connected to the gate of the third transistor.", "Note that a variety of switches can be used as a switch.", "For example, an electrical switch, a mechanical switch, or the like can be used.", "That is, any element can be used as long as it can control a current flow, without limitation to a certain element.", "For example, a transistor (e.g., a bipolar transistor or a MOS transistor), a diode (e.g., a PN diode, a PIN diode, a Schottky diode, an MIM (metal insulator metal) diode, an MIS (metal insulator semiconductor) diode, or a diode-connected transistor), or the like can be used as a switch.", "Alternatively, a logic circuit in which such elements are combined can be used as a switch.", "An example of a mechanical switch is a switch formed using a MEMS (micro electro mechanical system) technology, such as a digital micromirror device (DMD).", "Note that a CMOS switch may be used as a switch by using both an n-channel transistor and a p-channel transistor.", "Note that when it is explicitly described that “A and B are connected”, the case where A and B are electrically connected, the case where A and B are functionally connected, and the case where A and B are directly connected are included therein.", "Here, each of A and B is an object (e.g., a device, an element, a circuit, a wiring, an electrode, a terminal, a conductive film, or a layer).", "Accordingly, another element may be interposed between elements having a connection relation illustrated in drawings and texts, without limitation to a predetermined connection relation, for example, the connection relation illustrated in the drawings and the texts.", "For example, in the case where A and B are electrically connected, one or more elements which enable electrical connection between A and B (e.g., a switch, a transistor, a capacitor, an inductor, a resistor, and/or a diode) may be connected between A and B. Alternatively, in the case where A and B are functionally connected, one or more circuits which enable functional connection between A and B (e.g., a logic circuit such as an inverter, a NAND circuit, or a NOR circuit; a signal converter circuit such as a DA converter circuit, an AD converter circuit, or a gamma correction circuit; a potential level converter circuit such as a power supply circuit (e.g., a dc-dc converter, a step-up dc-dc converter, or a step-down dc-dc converter) or a level shifter circuit for changing a potential level of a signal; a voltage source; a current source; a switching circuit; an amplifier circuit such as a circuit which can increase signal amplitude, the amount of current, or the like, an operational amplifier, a differential amplifier circuit, a source follower circuit, or a buffer circuit; a signal generation circuit; a memory circuit; and/or a control circuit) may be connected between A and B.", "For example, in the case where a signal output from A is transmitted to B even when another circuit is interposed between A and B, A and B are functionally connected.", "Note that when it is explicitly described that “A and B are electrically connected”, the case where A and B are electrically connected (i.e., the case where A and B are connected with another element or another circuit interposed therebetween), the case where A and B are functionally connected (i.e., the case where A and B are functionally connected with another circuit interposed therebetween), and the case where A and B are directly connected (i.e., the case where A and B are connected without another element or another circuit interposed therebetween) are included therein.", "That is, when it is explicitly described that “A and B are electrically connected”, the description is the same as the case where it is explicitly only described that “A and B are connected”.", "Note that a display element, a display device which is a device including a display element, a light-emitting element, and a light-emitting device which is a device including a light-emitting element can employ various modes and can include various elements.", "For example, a display medium, whose contrast, luminance, reflectivity, transmittance, or the like changes by electromagnetic action, such as an EL (electroluminescence) element (e.g., an EL element including organic and inorganic materials, an organic EL element, or an inorganic EL element), an LED (e.g., a white LED, a red LED, a green LED, or a blue LED), a transistor (a transistor which emits light depending on the amount of current), an electron emitter, a liquid crystal element, electronic ink, an electrophoretic element, a grating light valve (GLV), a plasma display panel (PDP), a digital micromirror device (DMD), a piezoelectric ceramic display, or a carbon nanotube can be used as a display element, a display device, a light-emitting element, or a light-emitting device.", "Note that display devices having EL elements include an EL display; display devices having electron emitters include a field emission display (FED), an SED-type flat panel display (SED: surface-conduction electron-emitter display), and the like; display devices having liquid crystal elements include a liquid crystal display (e.g., a transmissive liquid crystal display, a transflective liquid crystal display, a reflective liquid crystal display, a direct-view liquid crystal display, or a projection liquid crystal display); display devices having electronic ink or electrophoretic elements include electronic paper.", "Note that a liquid crystal element is an element which controls transmission or non-transmission of light by optical modulation action of liquid crystals and includes a pair of electrodes and liquid crystals.", "Note that the optical modulation action of liquid crystals is controlled by an electric filed applied to the liquid crystals (including a horizontal electric field, a vertical electric field, and a diagonal electric field).", "Note that the following can be used for a liquid crystal element: a nematic liquid crystal, a 6 cholesteric liquid crystal, a smectic liquid crystal, a discotic liquid crystal, a thermotropic liquid crystal, a lyotropic liquid crystal, a low-molecular liquid crystal, a high-molecular liquid crystal, a polymer dispersed liquid crystal (PDLC), a ferroelectric liquid crystal, an anti-ferroelectric liquid crystal, a main-chain liquid crystal, a side-chain high-molecular liquid crystal, a plasma addressed liquid crystal (PALC), a banana-shaped liquid crystal, and the like.", "In addition, the following can be used as a diving method of a liquid crystal: a TN (twisted nematic) mode, an STN (super twisted nematic) mode, an IPS (in-plane-switching) mode, an FFS (fringe field switching) mode, an MVA (multi-domain vertical alignment) mode, a PVA (patterned vertical alignment) mode, an ASV (advanced super view) mode, an ASM (axially symmetric aligned 16 microcell) mode, an OCB (optically compensated birefringence) mode, an ECB (electrically controlled birefringence) mode, an FLC (ferroelectric liquid crystal) mode, an AFLC (anti-ferroelectric liquid crystal) mode, a PDLC (polymer dispersed liquid crystal) mode, a guest-host mode, a blue phase mode, and the like.", "Note that the present invention is not limited to this, and a variety of liquid crystal elements and driving methods thereof can be used as a liquid crystal element and a driving method thereof.", "Note that electroluminescence, a cold cathode fluorescent lamp, a hot cathode fluorescent lamp, an LED, a laser light source, a mercury lamp, or the like can be used as a light source of a display device in which a light source is needed, such as a liquid crystal display (e.g., a transmissive liquid crystal display, a transflective liquid crystal display, a reflective liquid crystal display, a direct-view liquid crystal display, or a projection liquid crystal display), a display device including a grating light valve (GLV), or a display device including a digital micromirror device (DMD).", "Note that the present invention is not limited to this, and a variety of light sources can be used as a light source.", "Note that a variety of transistors can be used as a transistor, without limitation to a certain type.", "For example, a thin film transistor (TFT) including a non-single-crystal semiconductor film typified by amorphous silicon, polycrystalline silicon, microcrystalline (also referred to as microcrystal, nanocrystal, or semi-amorphous) silicon, or the like can be used.", "Note that by using a catalyst (e.g., nickel) in the case of forming microcrystalline silicon, crystallinity can be further improved and a transistor having excellent electrical characteristics can be formed.", "In this case, crystallinity can be improved by just performing heat treatment without performing laser irradiation.", "Accordingly, a gate driver circuit (e.g., a scan line driver circuit) and part of a source driver circuit (e.g., an analog switch) can be formed using the same substrate as a pixel portion.", "In addition, in the case of not performing laser irradiation for crystallization, unevenness in crystallinity of silicon can be suppressed.", "Therefore, high-quality images can be displayed.", "Note that polycrystalline silicon and microcrystalline silicon can be formed without using a catalyst (e.g., nickel).", "A transistor can be formed using a semiconductor substrate, an SOI substrate, or the like.", "Thus, a transistor with few variations in characteristics, sizes, shapes, or the like, with high current supply capability, and with a small size can be formed.", "By using such a transistor, power consumption of a circuit can be reduced or a circuit can be highly integrated.", "A transistor including a compound semiconductor or an oxide semiconductor, such as ZnO, a-InGaZnO, SiGe, GaAs, IZO, ITO, or SnO, a thin film transistor obtained by thinning such a compound semiconductor or an oxide semiconductor, or the like can be used.", "Thus, manufacturing temperature can be lowered and for example, such a transistor can be formed at room temperature.", "Accordingly, the transistor can be formed directly on a substrate having low heat resistance, such as a plastic substrate or a film substrate.", "Note that such a compound semiconductor or an oxide semiconductor can be used not only for a channel portion of the transistor but also for other applications.", "For example, such a compound semiconductor or an oxide semiconductor can be used for a resistor, a pixel electrode, or a light-transmitting electrode.", "Further, since such an element can be formed at the same time as the transistor, cost can be reduced.", "A transistor or the like formed by an inkjet method or a printing method can be used.", "Thus, a transistor can be formed at room temperature, can be formed at a low vacuum, or can be formed using a large substrate.", "Since the transistor can be formed without using a mask (reticle), the layout of the transistor can be easily changed.", "Further, since it is not necessary to use a resist, material cost is reduced and the number of steps can be reduced.", "Furthermore, since a film is formed only in a necessary portion, a material is not wasted as compared to a manufacturing method by which etching is performed after the film is formed over the entire surface, so that cost can be reduced.", "A transistor or the like including an organic semiconductor or a carbon nanotube can be used.", "Thus, such a transistor can be formed over a flexible substrate.", "A semiconductor device formed using such a substrate can resist shocks.", "Further, transistors with a variety of structures can be used.", "For example, a MOS transistor, a junction transistor, a bipolar transistor, or the like can be used as a transistor.", "By using a MOS transistor, the size of the transistor can be reduced.", "Thus, a large number of transistors can be mounted.", "By using a bipolar transistor, large current can flow.", "Thus, a circuit can be operated at high speed.", "Note that a MOS transistor, a bipolar transistor, and the like may be formed over one substrate.", "Thus, reduction in power consumption, reduction in size, high-speed operation, and the like can be achieved.", "Furthermore, a variety of transistors can be used.", "Note that a transistor can be formed using a variety of substrates, without limitation to a certain type.", "For example, a single crystal substrate, an SOI substrate, a glass substrate, a quartz substrate, a plastic substrate, a stainless steel substrate, a substrate including a stainless steel foil, or the like can be used as a substrate.", "Note that the structure of a transistor can be a variety of structures, without limitation to a certain structure.", "For example, a multi-gate structure having two or more gate electrodes can be used.", "By using the multi-gate structure, a structure where a plurality of transistors are connected in series is provided because channel regions are connected in series.", "As another example, a structure where gate electrodes are formed above and below a channel can be used.", "Note that when the gate electrodes are formed above and below the channel, a structure where a plurality of transistors are connected in parallel is provided.", "A structure where a gate electrode is formed above a channel region, a structure where a gate electrode is formed below a channel region, a staggered structure, an inverted staggered structure, a structure where a channel region is divided into a plurality of regions, or a structure where channel regions are connected in parallel or in series can be used.", "Alternatively, a structure where a source electrode or a drain electrode overlaps with a channel region (or part of it) can be used.", "Further, an LDD region may be provided.", "Note that a variety of transistors can be used as a transistor, and the transistor can be formed using a variety of substrates.", "Accordingly, all the circuits that are necessary to realize a predetermined function can be formed using the same substrate.", "For example, all the circuits that are necessary to realize the predetermined function can be formed using a glass substrate, a plastic substrate, a single crystal substrate, an SOT substrate, or any other substrate.", "Alternatively, some of the circuits which are necessary to realize the predetermined function can be formed using one substrate and some of the circuits which are necessary to realize the predetermined function can be formed using another substrate.", "That is, not all the circuits that are necessary to realize the predetermined function are required to be formed using the same substrate.", "For example, some of the circuits which are necessary to realize the predetermined function can be formed by transistors using a glass substrate and some of the circuits which are necessary to realize the predetermined function can be formed using a single crystal substrate, so that an IC chip formed by a transistor using the single crystal substrate can be connected to the glass substrate by COG (chip on glass) and the IC chip may be provided over the glass substrate.", "Alternatively, the IC chip can be connected to the glass substrate by TAB (tape automated bonding) or a printed wiring board.", "Alternatively, when circuits with high driving voltage and high driving frequency, which consume large power, are formed using a single crystal substrate instead of forming such circuits using the same substrate, and an IC chip formed by the circuits is used, for example, increase in power consumption can be prevented.", "Note that a transistor is an element having at least three terminals of a gate, a drain, and a source.", "The transistor has a channel region between a drain region and a source region, and current can flow through the drain region, the channel region, and the source region.", "Here, since the source and the drain of the transistor change depending on the structure, the operating condition, and the like of the transistor, it is difficult to define which is a source or a drain.", "Thus, a region which functions as a source and a drain is not referred to as a source or a drain in some cases.", "In such a case, one of the source and the drain might be referred to as a first terminal and the other of the source and the drain might be referred to as a second terminal, for example.", "Alternatively, one of the source and the drain might be referred to as a first electrode and the other of the source and the drain might be referred to as a second electrode.", "Alternatively, one of the source and the drain might be referred to as a first region and the other of the source and the drain might be referred to as a second region.", "Note that a transistor may be an element having at least three terminals of a base, an emitter, and a collector.", "In this case, in a similar manner, one of the emitter and the collector might be referred to as a first terminal and the other of the emitter and the collector might be referred to as a second terminal.", "Note that a semiconductor device corresponds to a device having a circuit including a semiconductor element (e.g., a transistor, a diode, or a thyristor).", "The semiconductor device may also correspond to all devices that can function by utilizing semiconductor characteristics.", "In addition, the semiconductor device corresponds to a device having a semiconductor material.", "Note that a display device corresponds to a device having a display element.", "The display device may include a plurality of pixels each having a display element.", "Note that the display device may include a peripheral driver circuit for driving the plurality of pixels.", "Note that the peripheral driver circuit for driving the plurality of pixels may be formed using the same substrate as the plurality of pixels.", "The display device may include a peripheral driver circuit provided over a substrate by wire bonding or bump bonding, namely, an IC chip connected by chip on glass (COG) or an IC chip connected by TAB or the like.", "The display device may include a flexible printed circuit (FPC) to which an IC chip, a resistor, a capacitor, an inductor, a transistor, or the like is attached.", "Note that the display device may include a printed wiring board (PWB) which is connected through a flexible printed circuit (FPC) and to which an IC chip, a resistor, a capacitor, an inductor, a transistor, or the like is attached.", "The display device may include an optical sheet such as a polarizing plate or a retardation plate.", "The display device may include a lighting device, a housing, an audio input and output device, an optical sensor, or the like.", "Note that a lighting device may include a backlight unit, a light guide plate, a prism sheet, a diffusion sheet, a reflective sheet, a light source (e.g., an LED or a cold cathode fluorescent lamp), a cooling device (e.g., a water cooling device or an air cooling device), or the like.", "Note that a light-emitting device corresponds to a device having a light-emitting element or the like.", "In the case where a light-emitting device includes a light-emitting element as a display element, the light-emitting device is one of specific examples of a display device.", "Note that a reflective device corresponds to a device having a light-reflective element, a light diffraction element, light-reflective electrode, or the like.", "Note that a liquid crystal display device corresponds to a display device including a liquid crystal element.", "Liquid crystal display devices include a direct-view liquid crystal display, a projection liquid crystal display, a transmissive liquid crystal display, a reflective liquid crystal display, a transflective liquid crystal display, and the like.", "Note that a driving device corresponds to a device having a semiconductor element, an electric circuit, or an electronic circuit.", "For example, a transistor which controls input of signals from a source signal line to pixels (also referred to as a selection transistor, a switching transistor, or the like), a transistor which supplies voltage or current to a pixel electrode, a transistor which supplies voltage or current to a light-emitting element, and the like are examples of the driving device.", "A circuit which supplies signals to a gate signal line (also referred to as a gate driver, a gate line driver circuit, or the like), a circuit which supplies signals to a source signal line (also referred to as a source driver, a source line driver circuit, or the like), and the like are also examples of the driving device.", "Note that a display device, a semiconductor device, a lighting device, a cooling device, a light-emitting device, a reflective device, a driving device, and the like overlap with each other in some cases.", "For example, a display device includes a semiconductor device and a light-emitting device in some cases.", "Alternatively, a semiconductor device includes a display device and a driving device in some cases.", "Note that when it is explicitly described that “B is formed on A” or “B is formed over A”, it does not necessarily mean that B is formed in direct contact with A.", "The description includes the case where A and B are not in direct contact with each other, i.e., the case where another object is interposed between A and B.", "Here, each of A and B is an object (e.g., a device, an element, a circuit, a wiring, an electrode, a terminal, a conductive film, or a layer).", "Accordingly, for example, when it is explicitly described that “a layer B is formed on (or over) a layer A”, it includes both the case where the layer B is formed in direct contact with the layer A, and the case where another layer (e.g., a layer C or a layer D) is formed in direct contact with the layer A and the layer B is formed in direct contact with the layer C or the layer D. Note that another layer (e.g., a layer C or a layer D) may be a single layer or a plurality of layers.", "In a similar manner, when it is explicitly described that “B is formed above A”, it does not necessarily mean that B is formed in direct contact with A, and another object may be interposed therebetween.", "Thus, for example, when it is described that “a layer B is formed above a layer A”, it includes both the case where the layer B is formed in direct contact with the layer A, and the case where another layer (e.g., a layer C or a layer D) is formed in direct contact with the layer A and the layer B is formed in direct contact with the layer C or the layer D. Note that another layer (e.g., a layer C or a layer D) may be a single layer or a plurality of layers.", "Note that when it is explicitly described that “B is formed on A”, “B is formed over A”, or “B is formed above A”, it includes the case where B is formed obliquely over/above A.", "Note that the same can be said when it is described that “B is formed below A” or “B is formed under A”.", "Note that when an object is explicitly described in a singular form, the object is preferably singular.", "Note that the present invention is not limited to this, and the object can be plural.", "In a similar manner, when an object is explicitly described in a plural form, the object is preferably plural.", "Note that the present invention is not limited to this, and the object can be singular.", "Note that size, the thickness of layers, or regions in diagrams are exaggerated for simplicity in some cases.", "Therefore, the present invention is not necessarily limited to the scale.", "Note that diagrams are schematic views of ideal examples, and shapes or values are not limited to those illustrated in the diagrams.", "For example, it is possible to include variations in shape due to a manufacturing technique or an error, variations in signals, voltage values, or current values due to noise or a difference in a timing.", "Note that a technical term is used in order to describe a particular embodiment or example or the like in many cases, and is not limited to this.", "Note that terms which are not defined (including terms used for science and technology, such as technical terms or academic parlance) can be used as terms which have meaning equal to general meaning that an ordinary person skilled in the art understands.", "It is preferable that terms defined by dictionaries or the like be construed as consistent meaning with the background of related art.", "Note that terms such as “first”, “second”, “third”, and the like are used for distinguishing various elements, members, regions, layers, and areas from others.", "Therefore, the terms such as “first”, “second”, “third”, and the like do not limit the number of the elements, members, regions, layers, areas, or the like.", "Further, for example, “first” can be replaced with “second”, “third”, or the like.", "The number of transistors connected to a capacitor can be decreased.", "Alternatively, the parasitic capacitance of a transistor connected to the capacitor can be decreased.", "Alternatively, the potential in an H level of a signal which synchronizes with a clock signal can be increased.", "Alternatively, a layout area can be reduced.", "Alternatively, life can be extended.", "Alternatively, delay or distortion of a signal can be decreased.", "Alternatively, power consumption can be decreased.", "Alternatively, the adverse effect of noise can be decreased.", "Alternatively, deterioration of a transistor can be suppressed or relieved.", "Alternatively, malfunction can be suppressed.", "Alternatively, short circuit between one electrode of a capacitor and the other electrode of the capacitor can be prevented.", "Alternatively, the current driving capability of an outside circuit can be decreased.", "Alternatively, the size of an outside circuit can be reduced.", "Alternatively, the size of a display device can be reduced.", "BRIEF DESCRIPTION OF DRAWINGS FIG.", "1A is a circuit diagram of a semiconductor device and FIG.", "1B is a timing chart for illustrating a driving method of the semiconductor device.", "FIGS.", "2A to 2E are schematic views illustrating a driving method of a semiconductor device.", "FIGS.", "3A to 3E are circuit diagrams of a semiconductor device.", "FIGS.", "4A to 4F are circuit diagrams of a semiconductor device.", "FIGS.", "5A to 5E are circuit diagrams of a semiconductor device.", "FIG.", "6A is a circuit diagram of a semiconductor device and FIGS.", "6B and 6C are timing charts each illustrating a driving method of the semiconductor device.", "FIGS.", "7A to 7C are schematic views illustrating a driving method of a semiconductor device.", "FIGS.", "8A and 8B are schematic views illustrating a driving method of a semiconductor device.", "FIGS.", "9A to 9C are circuit diagrams of a semiconductor device.", "FIGS.", "10A to 10C are circuit diagrams of a semiconductor device.", "FIGS.", "11A to 11C are circuit diagrams of a semiconductor device.", "FIGS.", "12A to 12C are circuit diagrams of a semiconductor device.", "FIGS.", "13A to 13C are circuit diagrams of a semiconductor device.", "FIG.", "14A is a circuit diagram of a shift register and FIG.", "14B is a timing chart illustrating a driving method of the shift register.", "FIG.", "15 is a circuit diagram of a shift register.", "FIG.", "16 is a circuit diagram of a shift register.", "FIGS.", "17A and 17B are circuit diagrams of a shift register.", "FIG.", "18 is a layout view of a shift register.", "FIG.", "19A is a circuit diagram of a semiconductor device and FIG.", "19B is a timing chart illustrating a driving method of the semiconductor device.", "FIGS.", "20A and 20B are circuit diagrams of a semiconductor device.", "FIG.", "21 is a circuit diagram of a shift register.", "FIGS.", "22A and 22B are system block diagrams of a display device.", "FIGS.", "23A to 23E are diagrams each illustrating a structure of a display device.", "FIG.", "24 is a circuit diagram of a shift register.", "FIGS.", "25A and 25B are timing charts each illustrating a driving method of a shift register.", "FIG.", "26A is a circuit diagram of a signal line driver circuit and FIG.", "26B is a timing chart illustrating a driving method of the signal line driver circuit.", "FIGS.", "27A to 27C, 27E, and 27F are circuit diagrams of a pixel and FIGS.", "27D and 27G are timing charts each illustrating a driving method of the pixel.", "FIGS.", "28A and 28B are circuit diagrams of a pixel, FIGS.", "28C to 28E and 28G are layout diagrams of the pixel, and FIGS.", "28F and 28H are timing charts each illustrating a driving method of the pixel.", "FIG.", "29A is a timing chart illustrating a driving method of a pixel and FIG.", "29B is a circuit diagram of the pixel.", "FIG.", "30 is a layout view of a shift register.", "FIG.", "31 is a layout view of a shift register.", "FIGS.", "32A to 32C are cross-sectional views of a transistor.", "FIGS.", "33A to 33H are diagrams illustrating electronic devices.", "FIGS.", "34A to 34H are diagrams illustrating electronic devices.", "BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, embodiments will be described with reference to the drawings.", "However, the embodiments can be implemented with various modes.", "It will be readily appreciated by those skilled in the art that modes and details can be changed in various ways without departing from the spirit and scope of the present invention.", "Therefore, the invention should not be construed as being limited to the description of embodiment.", "Note that in structures of the invention described below, the same portions or portions having similar functions are denoted by the same reference numerals, and description thereof is not repeated.", "Note that a content (or may be part of the content) described in one embodiment may be applied to, combined with, or replaced by a different content (or may be part of the different content) described in the same embodiment and/or a content (or may be part of the content) described in one or a plurality of different embodiments.", "Note that in each embodiment, a content described in the embodiment is a content described with reference to a variety of diagrams or a content described with a paragraph disclosed in this specification.", "Note that, by combining a diagram (or may be part of the diagram) described one embodiment with another part of the diagram, a different diagram (or may be part of the different diagram) described in the same embodiment, and/or a diagram (or may be part of the diagram) described in one or a plurality of different embodiments, much more diagrams can be formed.", "Embodiment 1 In this embodiment, one example of a semiconductor device will be described.", "Note that the semiconductor device can be denoted as a driver circuit or a flip-flop.", "First, one example of the semiconductor device of this embodiment will be described with reference to FIG.", "1A.", "The semiconductor device in FIG.", "1A includes a circuit 100, a transistor 101, a transistor 102, a transistor 103, a transistor 104, a capacitor 105, and a capacitor 106.Each of the transistors 101 to 104 is an n-channel transistor which is turned on when potential difference (Vgs) between a gate and a source gets higher than threshold voltage (Vth).", "However, this embodiment is not limited to this.", "Each of the transistors 101 to 104 can be a p-channel transistor.", "The p-channel transistor is turned on when potential difference (Vgs) between a gate and a source gets lower than threshold voltage (Vth).", "A connection relation of the semiconductor device in FIG.", "1A will be described.", "A first terminal of the transistor 101 is connected to a wiring 123B.", "A second terminal of the transistor 101 is connected to a wiring 121.A first terminal of the transistor 102 is connected to a gate of the transistor 101.A second terminal of the transistor 102 is connected to the wiring 121.A gate of the transistor 102 is connected to a wiring 123C.", "A first terminal of the transistor 103 is connected to a wiring 122A.", "A second terminal of the transistor 103 is connected to the gate of the transistor 101.A first terminal of the transistor 104 is connected to a wiring 122B.", "A second terminal of the transistor 104 is connected to the gate of the transistor 103.One electrode of the capacitor 105 is connected to the gate of the transistor 101.The other electrode of the capacitor 105 is connected to the wiring 121.One electrode of the capacitor 106 is connected to the wiring 123A.", "The other electrode of the capacitor 106 is connected to the gate of the transistor 103.Note that a connection portion of the gate of the transistor 101, the first terminal of the transistor 102, the second terminal of the transistor 103, or the gate of the transistor 104 is denoted as a node A.", "Then, a connection portion of the gate of the transistor 103, the second terminal of the transistor 104, or the other electrode of the capacitor 106 is denoted as a node B.", "Note that the node A and the node B can be denoted as wirings.", "Note that the wiring 121, the wiring 123A, the wiring 123B, the wiring 123C, the wiring 122A, and the wiring 122B can be denoted as terminals.", "One example of a thing (e.g., a signal, voltage, or current) which can be input to each of the wirings (the wiring 121, the wirings 122A and 122B, and the wirings 123A to 123C) is described.", "However, a content described below is an example and this embodiment is not limited to this.", "A variety of things besides the thing described below can be input to each of the wirings.", "Each of the wirings can be in a floating state.", "For example, a signal S1 is output from the wiring 121.Accordingly, the wiring 121 can function as a signal line.", "In specific, in the case where the wiring 121 is connected to a pixel, or in the case where the wiring 121 is provided so as to extend to a pixel portion, the wiring 121 can function as a gate line, a scan line, or a capacitor line.", "The signal S1 is an output signal of the semiconductor device and is a digital signal having an H level and an L level in many cases.", "The signal S1 can function as an output signal, a selection signal, a gate signal, or a scan signal.", "For example, voltage V1 is supplied to the wirings 122A and 122B.", "Accordingly, the wirings 122A and 122B can function as power supply lines.", "The voltage V1 has approximately the same value as the signal S1 in an L level in many cases and can function as ground voltage, power supply voltage, or negative power supply voltage.", "However, this embodiment is not limited to this.", "A signal such as a clock signal can be input to the wirings 122A and 122B.", "In that case, the wirings 122A and 122B can function as signal lines or clock signal lines.", "Alternatively, different voltages or different signals can be input to the wirings 122A and 122B.", "Note that the term “approximately” means that a value includes a variety of errors such as an error due to noise, an error due to variations in a process, an error due to variations in steps of manufacturing an element, and/or a measurement error.", "For example, a signal S2 is input to the wirings 123A to 123C.", "Accordingly, the wirings 123A to 123C can function as signal lines.", "The signal S2 is a digital signal which repeatedly switch between an H level and an L level in a certain cycle in many cases and can function as a clock signal (CK).", "However, this embodiment is not limited to this.", "Power supply voltage can be supplied to the wirings 123A to 123C.", "In that case, the wirings 123A to 123C can function as power supply lines.", "Alternatively, different voltages or different signals can be input to the wirings 123A to 123C.", "Note that in this embodiment, when the potential in an L level of a signal is V1 and the potential in an H level of a signal is V2, for example, V2 is higher than V1.However, this embodiment is not limited to this.", "Note that voltage means a potential difference between one potential and reference potential (e.g., ground potential) in many cases.", "Accordingly, voltage, potential and a potential difference can be referred to as potential, voltage, and a voltage difference, respectively.", "Examples of functions which the circuit 100, the transistors 101 to 104, the capacitor 105, and the capacitor 106 have will be described.", "However, a content described below is one example and this embodiment is not limited to the content below.", "The circuit 100 and each element can have a variety of functions in addition to the functions described below.", "Alternatively, it is possible that the circuit 100 and each element do not have the functions described below.", "The circuit 100 has a function of controlling the potential or state of the node A and a function of controlling the potential or state of the wiring 121.For example, the circuit 100 has a function of raising the potential of the node A or the wiring 121, a function of decreasing the potential of the node A or the wiring 121, and/or a function of making the node A or the wiring 121 go into a floating state, or the like.", "The transistor 101 has a function of raising the potential of the wiring 121 in accordance with a signal (e.g., the signal S2) which is input to the wiring 123B.", "The transistor 102 has a function of controlling a timing when the wiring 121 and the node A are brought into electrical conduction in accordance with a signal (e.g., the signal S2) which is input to the wiring 123C and functions as a switch.", "The transistor 103 has a function of controlling a timing when the wiring 122A and the node A are brought into electrical conduction in accordance with the potential of the node B and functions as a switch.", "The transistor 104 has a function of controlling a timing when the wiring 122B and the node B are brought into electrical conduction in accordance with the potential of the node A and functions as a switch.", "The capacitor 105 has a function of raising the potential of the node A in accordance with the potential of the wiring 126 and/or a function of holding a potential difference between the gate and the second terminal of the transistor 101.The capacitor 106 has a function of controlling the potential of the node B in accordance with a signal (e.g., the signal S2) which is input to the wiring 123A.", "Next, operation of the semiconductor device in FIG.", "1A will be described with reference to FIG.", "1B and FIGS.", "2A to 2E.", "FIG.", "1B is one example of a timing chart for illustrating the operation of the semiconductor device and there are a period T1, a period T2, a period T3, a period T4, and a period T5.In addition, FIG.", "1B shows the signal S1, the signal S2, the potential Va of the node A, and the potential Vb of the node B.", "FIG.", "2A is a schematic view of operation of the semiconductor device in FIG.", "1A during the period T1.FIG.", "2B is a schematic view of the operation of the semiconductor device in FIG.", "1A during the period T2.FIG.", "2C is a schematic view of the operation of the semiconductor device in FIG.", "1A during the period T3.FIG.", "2D is a schematic view of the operation of the semiconductor device in FIG.", "1A during the period T4.FIG.", "2E is a schematic view of the operation of the semiconductor device in FIG.", "1A during the period T5.Note that when the potential of the node A is raised, the semiconductor device sequentially performs operation during the period T1, operation during the period T2, and operation during the period T3.After that, the semiconductor device sequentially repeats operation during the period T4 and operation during the period T5 until the potential of the node A is raised again.", "First, the signal S2 goes into an L level in the period T1.Then, the transistor 102 is turned off, so that the node A and the wiring 121 are brought out of electrical conduction.", "At the same time, the potential of the node B decreases due to capacitive coupling of the capacitor 106.When the potential of the node B at that time gets lower than the sum of the potential (V1) of the wiring 122A and the threshold voltage (Vth106) of the transistor 103, (V1+Vth106), the transistor 103 is turned off.", "Accordingly, the wiring 122A and the node A are brought out of electrical conduction.", "On the other hand, the circuit 100 starts to raise the potential of the node A.", "Then, when the potential of the node A becomes equal to the sum of the potential (V1) of the wiring 122B and the threshold voltage (Vth104) of the transistor 104, (V1+Vth104), the transistor 104 is turned on.", "Accordingly, the wiring 122B and the node B are brought into electrical conduction.", "Therefore, since the voltage V1 is supplied from the wiring 122B to the node B, the potential of the node B is V1.As a result, since the transistor 103 is kept off, the wiring 122A and the node A are kept out of electrical conduction.", "Similarly, when the potential of the node A becomes equal to the sum of the potential (V1) of the wiring 123B and the threshold voltage (Vth101) of the transistor 101, (V1+Vth101), the transistor 101 is turned on.", "Accordingly, the wiring 123B and the wiring 121 are brought into electrical conduction.", "Therefore, since the signal S2 in the L level is supplied from the wiring 123B to the wiring 121, the potential of the wiring 121 is approximately equal to the potential of the wiring 123B (the L level of the signal S2 or V1).", "After that, since the circuit 100 stops supplying a signal to the node A when the potential of the node A is raised to a certain value (e.g., more than or equal to V1+Vth101 and less than or equal to V2), the circuit 100 and the node A are brought out of electrical conduction.", "Accordingly, the node A goes into a floating state, so that the potential of the node A is maintained as a large value.", "A potential difference between the node A and the wiring 121 at that time is held in the capacitor 105.Note that the circuit 100 can supply the voltage V1, a signal in an L level, or the like to the wiring 121 during the period T1.Alternatively, the circuit 100 and the wiring 121 can be brought out of electrical conduction if the circuit 100 does not supply the signal or the like to the wiring 121.In addition, the circuit 100 can make the wiring 121 go into a floating state.", "Next, since the potential of the node A is maintained as a large value during the period T2, the transistor 104 is kept on.", "Accordingly, since the wiring 122B and the node B are kept in electrical conduction, the potential of the node B is kept as V1.As a result, the transistor 103 is kept off, so that the wiring 122A and the node A are kept out of electrical conduction.", "Similarly, since the potential of the node A is maintained as a large value, the transistor 101 is kept on.", "Therefore, the wiring 123B and the wiring 121 are kept in electrical conduction.", "At that time, the level of the signal S2 raises from the L level to an H level.", "Accordingly, since the wiring 123B and the wiring 121 are kept in electrical conduction, the potential of the wiring 121 starts to be raised.", "Since the transistor 102 is turned on at the same time, the node A and the wiring 121 are brought into electrical conduction.", "However, the transistor 102 is turned off when the potential of the wiring 121 is raised to a value obtained by subtracting the threshold voltage (Vth102) of the transistor 102 from the potential (V2) of the wiring 123C, (V2−Vth102).", "Accordingly, the wiring 121 and the node A are brought out of electrical conduction.", "Here, the capacitor 105 keeps holding the potential difference between the wiring 121 and the node A in the period T1.Accordingly, when the potential of the wiring 121 is raised, the potential of the node A is raised to (V2+Vth101+α) (α is a positive number) by capacitive coupling of the capacitor 105.So-called bootstrap operation is performed.", "Accordingly, the potential of the wiring 121 is raised until it becomes equal to the potential (the H level of the signal S2 or V2) of the wiring 123B.", "Note that since the circuit 100 does not supply a signal or the like to the node A during the period T2 in many cases, the circuit 100 and the node A are out of electrical conduction in many cases.", "In this manner, the circuit 100 makes the node A go into a floating state in many cases.", "Note that since the circuit 100 does not supply a signal or the like to the wiring 121 during the period T2 in many cases, the circuit 100 and the wiring 121 are out of electrical conduction in many cases.", "Next, the circuit 100 decreases the potential of the node A to V1 after the level of the signal S2 is dropped from the H level to the L level during the period T3.Accordingly, the transistor 101 is on until the potential of the node A becomes equal to the sum of the potential (V1) of the wiring 123B and the threshold voltage (Vth101) of the transistor 101, (V1+Vth101).", "Accordingly, since the signal S2 in the L level is supplied from the wiring 123B to the wiring 121, the potential of the wiring 121 decreases to the potential (V1) of the wiring 123B.", "Similarly, the transistor 104 is on until the potential of the node A becomes equal to the sum of the potential (V1) of the wiring 122B and the threshold voltage (Vth104) of the transistor 104, (V1+Vth104).", "Accordingly, since the voltage V1 is supplied from the wiring 122B to the node B, the potential of the node B is kept as V1.As a result, the transistor 103 is kept off, so that the wiring 122A and the node A are kept out of electrical conduction.", "At that time, the capacitor 106 holds the potential difference between the potential of the wiring 123A (the L level of the signal S2 or V1) and the potential (V1) of the wiring 122B.", "Note that the circuit 100 can supply the voltage V1, a signal in an L level, or the like to the wiring 121 during the period T3.Alternatively, the circuit 100 and the wiring 121 can be brought out of electrical conduction if the circuit 100 does not supply the signal or the like to the wiring 121.In addition, the circuit 100 can make the wiring 121 go into a floating state.", "Next, the level of the signal S2 is raised from the L level to the H level during the period T4.At that time, since the potential of the node A is kept as V1, the transistor 101 and the transistor 104 are kept off.", "Accordingly, since the node B is kept in a floating state, the potential of the node B is raised by capacitive coupling of the capacitor 106.When the potential of the node B gets higher than the sum of the potential (V1) of the wiring 122A and the threshold voltage (Vth103) of the transistor 103, (V1+Vth103), the transistor 103 is turned on.", "Then, the wiring 122A and the node A are brought into electrical conduction.", "Accordingly, since the voltage V1 is supplied from the wiring 122A to the node A, the potential of the node A is maintained as V1.At the same time, since the transistor 102 is turned on, the wiring 121 and the node A are brought into electrical conduction.", "At that time, the voltage V1 is supplied from the wiring 122A to the node A.", "Accordingly, since the voltage V1 is supplied from the wiring 122A to the wiring 121, the potential of the wiring 121 is maintained as V1.Note that the circuit 100 can supply the voltage V1, a signal in an L level, or the like to the node A during the period T4.Alternatively, the circuit 100 and the wiring 121 can be brought out of electrical conduction if the circuit 100 does not supply the signal or the like to the node A.", "In addition, the circuit 100 can make the node A go into a floating state.", "Note that the circuit 100 can supply the voltage V1, a signal in an L level, or the like to the wiring 121 during the period T5.Alternatively, the circuit 100 and the wiring 121 can be brought out of electrical conduction if the circuit 100 does not supply the signal or the like to the wiring 121.In addition, the circuit 100 can make the wiring 121 go into a floating state.", "Next, the level of the signal S2 is dropped from the H level to the L level during the period T5.At that time, since the potential of the node A is kept as V1, the transistor 101 and the transistor 104 are kept off.", "Accordingly, the potential of the node B is decreased by capacitive coupling of the capacitor 106.When the potential of the node B gets lower than the sum of the potential (V1) of the wiring 122A and the threshold voltage (Vth103) of the transistor 103, (V1+Vth103), the transistor 103 is turned off.", "Then, the wiring 122A and the node A are brought out of electrical conduction.", "Similarly, since the transistor 102 is turned off, the wiring 121 and the node A are brought out of electrical conduction.", "At that time, if the circuit 100 supplies the signal in the L level or the voltage V1 to the node A and the wiring 121, the potential of the node A and the potential of the wiring 121 are maintained as V1.However, even if the circuit 100 does not supply the signal in the L level or the voltage V1 to the node A and the wiring 121, the node A and the wiring 121 go into a floating state, whereby the potential of the node A and the potential of the wiring 121 are maintained as V1.In the semiconductor device in FIG.", "1A, the number of transistors that are connected to the other electrode of the capacitor 106 can be smaller than that of a conventional technique.", "Accordingly, the parasitic capacitance of a node connected to the other of the capacitor 106, that is, the parasitic capacitance of the node B can be made low.", "Note that the parasitic capacitance means total capacitance such as the gate capacitance of a transistor, the parasitic capacitance between a gate and source of the transistor, the parasitic capacitance between the gate and drain of the transistor, and/or wiring capacitance.", "However, this embodiment is not limited to this.", "A plurality of transistors can be connected to the other electrode of the capacitor 106.Alternatively, since the parasitic capacitance of the node B can be reduced in the semiconductor device shown in FIG.", "1A, the capacitance value of the capacitor 106 can be made smaller than that of the conventional technique.", "Accordingly, since an area where one electrode of the capacitor 106 and the other electrode of the capacitor 106 overlap with each other can be reduced, the layout area of the capacitor 106 can be reduced.", "As a result, short circuit between one electrode of the capacitor 106 and the other electrode of the capacitor 106 due to dust or the like can be prevented.", "Accordingly, improvement in yield or reduction in cost can be achieved.", "Alternatively, since the load of the wiring 123A can be reduced, distortion, delay, or the like of a signal (e.g., a signal S2) which is input to the wiring 123A can be suppressed.", "Alternatively, since the current driving capability of an outside circuit for supplying a signal to the wiring 123A can be made low, the size of the outside circuit can be reduced.", "Alternatively, since the parasitic capacitance of the node B can be reduced in the semiconductor device in FIG.", "1A, the amplitude voltage of the node B in the case where the potential of the wiring 123A is changed can be made high.", "Accordingly, during the period T4, since the potential of the node B can be made higher than that of the conventional technique, the Vgs of the transistor 103 can be made big.", "That is, since the on resistance of the transistor 103 can be made low, the potential of the node B during the period T4 can be easily maintained as V1.Alternatively, since the channel width (W) of the transistor 103 can be made small, reduction in a layout area can be achieved.", "Alternatively, in the semiconductor device shown in FIG.", "1A, during the period T2, the node A and the wiring 121 are in electrical conduction until the transistor 102 is turned off in many cases.", "Accordingly, since the potential of the node A is decreased, the gate voltage of the transistor 101 and the transistor 104 can be reduced.", "As a result, deterioration of characteristics of the transistor 101 and the transistor 104 can be suppressed.", "Alternatively, a breakdown of the transistor 101 and the transistor 104 can be suppressed.", "Alternatively, a transistor whose mobility is improved by thinning a gate insulating film can be used as the transistor.", "In the case where such a transistor is used, the channel width (W) of the transistor can be reduced.", "Accordingly, reduction in a layout area can be achieved.", "Alternatively, all transistors in the semiconductor device in FIG.", "1A can be n-channel transistors or p-channel transistors.", "Accordingly, as compared to a CMOS circuit, reduction in the number of steps, improvement in yield, or reduction in cost can be achieved.", "In specific, if all the transistors are n-channel transistors, a non-single-crystal semiconductor, a microcrystalline semiconductor, an organic semiconductor, or an oxide semiconductor can be used for a semiconductor layer of the transistor.", "Accordingly, reduction in the number of steps, improvement in yield, or reduction in cost can be achieved.", "However, this embodiment is not limited to this.", "The semiconductor device shown in FIG.", "1A can be formed using a CMOS circuit in which a p-channel transistor and an n-channel transistor are combined.", "Alternatively, in the semiconductor device shown in FIG.", "1A, the transistors 101 to 104 are turned off during at least one of the period T4 and the period T5.Accordingly, since the transistor is not turned on during one operation period, deterioration of characteristics of the transistor, such as increase in threshold voltage or decrease in mobility can be suppressed.", "In specific, in the case where the non-single-crystal semiconductor, the microcrystalline semiconductor, the organic semiconductor, or the oxide semiconductor is used for the semiconductor layer of the transistor, deterioration of the characteristics of the transistor becomes obvious.", "However, in the semiconductor device shown in FIG.", "1A, deterioration of the characteristics of the transistor can be suppressed; therefore, the non-single-crystal semiconductor, the microcrystalline semiconductor, the organic semiconductor, or the oxide semiconductor can be used for the semiconductor layer of the transistor.", "However, this embodiment is not limited to this.", "A polycrystalline semiconductor or a single crystal semiconductor can be used for the semiconductor layer.", "Note that the period T2 can be referred to as a selection period and periods other than the period T2 (the period T1, the period T3, the period T4, and the period T5) can be referred to as non-selection periods.", "Alternatively, the period T1, the period T2, the period T3, the period T4, and the period T5 can be referred to as a set period, an output period, a reset period, a first non-selection period, and a second non-selection period, respectively.", "Note that the channel width (W) of the transistor 101 can be larger than that of the transistor 102, the transistor 103, and/or the transistor 104.Alternatively, the channel width of the transistor 101 can be the largest among those of the transistors included in the semiconductor device.", "In that case, since the on resistance of the transistor 101 is low, rising time and falling time of a signal (e.g., the signal S1) which is output from the wiring 121 can be shortened.", "Accordingly, during the period T2, a timing when the transistor 102 is turned off comes earlier.", "Therefore, malfunction of the semiconductor device due to too much reduction in the potential of the node A can be suppressed.", "However, this embodiment is not limited to this.", "The channel width of the transistor 101 can be smaller than that of any one of the transistors 102 to 104 or that of any one of the transistors included in the semiconductor device.", "Note that the channel width of the transistor can also be referred to as a W/L ratio of the transistor (L: channel length).", "Note that the potential of the signal in an L level which is input to the wiring 123A, the wiring 123B, and/or the wiring 123C can be lower than V1.In that case, backward bias can be applied to the transistor, so that deterioration of the characteristics of the transistor can be suppressed.", "In specific, since a period of time when the transistor 102 is on is long, the potential of the signal in the L level that is input to the wiring 123C is preferably lower than V1.However, this embodiment is not limited to this.", "The potential of the signal in the L level that is input to the wiring 123A, the wiring 123B, and/or the wiring 123C can be higher than V1.Note that the potential of the signal in an H level which is input to the wiring 123A, the wiring 123B, and/or the wiring 123C can be lower than V2.In that case, the Vgs of the transistor is small, so that deterioration of the characteristics of the transistor can be cased.", "In specific, since a period of time when the transistor 102 is on is long, the potential of the signal in the H level that is input to the wiring 123C is preferably lower than V2.However, this embodiment is not limited to this.", "The potential of the signal in the H level that is input to the wiring 123A, the wiring 123B, and/or the wiring 123C can be higher than V2.Note that the amplitude voltage of the signal that is input to the wiring 123A, the wiring 123B, and/or the wiring 123C can be lower than (V2−V1).", "In specific, since a period of time when the transistor 103 is on is long, the amplitude of the signal that is input to the wiring 123A is preferably lower than (V2−V1).", "In this manner, since the Vgs of the transistor 103 can be made small, deterioration of the characteristics of the transistor 103 can be suppressed.", "However, this embodiment is not limited to this.", "The amplitude voltage of the signal that is input to the wiring 123A, the wiring 123B, and/or the wiring 123C can be higher than (V2−V1).", "Note that a signal can be input to the wiring 122A and/or the wiring 122B.", "In this manner, since the voltage V1 can be eliminated, the number of power supplies can be reduced.", "Alternatively, since backward bias can be applied to the transistor, deterioration of the characteristics of the transistor can be eased.", "In specific, a signal whose level goes into an L level during a period when the transistor 103 is on (e.g., the period T1, the period T3, and the period T5) can be input to the wiring 122A.", "For example, an inverted signal (hereinafter also referred to as an inverted clock signal) of the signal S2 can be given.", "A signal whose level goes into an L level during a period when the transistor 104 is on (e.g., the period T3, the period T4, and the period T5) can be input to the wiring 122B.", "Note that voltage (e.g., the voltage V2) can be supplied to the wiring 123A, the wiring 123B, and/or the wiring 123C.", "Accordingly, the semiconductor device can function as an inverter circuit or a buffer circuit.", "Note that as shown in FIG.", "3A, since the same voltages (e.g., the voltage V1) are supplied to the wiring 122A and 122B in many cases, the wiring 122A and the wiring 122B can be shared.", "Accordingly, the first terminal of the transistor 103 and the first terminal of the transistor 104 are connected to the wiring 122.The wiring 122 corresponds to the wiring 122A or the wiring 122B.", "A signal similar to that input to the wiring 122A or the wiring 122B can be input to the wiring 122.Note that the terms “a plurality of wirings is shared” mean that an element or a circuit which is connected to the plurality of wirings is connected to one wiring.", "Alternatively, the terms “a plurality of wirings is shared” mean that the plurality of wirings is connected to each other.", "Note that as shown in FIG.", "3B, since the same signals (e.g., the signal S2) are input to the wirings 123A to 123C in many cases, the wiring 123A to 123C can be shared.", "Accordingly, the first terminal of the transistor 101, the gate of the transistor 102, and one electrode of the capacitor 106 are connected to the wiring 123.The wiring 123 corresponds to the wirings 123A to 123C.", "A signal similar to that input to the wirings 123A to 123C can be input to the wiring 123.However, this embodiment is not limited to this.", "Any two or more of the wirings 123A to 123C can be shared.", "Note that as in FIG.", "3B, the wirings 123A to 123C can be shared in FIG.", "3A.", "Note that as shown in FIG.", "3C, by combining FIGS.", "3A and 3B, the wiring 122A and the wiring 122B can be shared and, further, the wirings 123A to 123C can be shared.", "For example, the first terminal of the transistor 103 and the first terminal of the transistor 104 can be connected to the wiring 122.In addition, the first terminal of the transistor 101, the gate of the transistor 102, and one electrode of the capacitor 106 can be connected to the wiring 123.Note that as shown in FIG.", "3D, the gate of the transistor 104 can be connected to the wiring 121.Since the gate of the transistor 104 is connected to the wiring 121, the voltage of the gate when the transistor 104 is turned on is V which is lower than the voltage (V1+Vth101+α) of the gate when the transistor 104 is turned on in FIG.", "1A.", "Accordingly, a dielectric breakdown of the transistor 104 or deterioration of characteristics of the transistor 104 can be suppressed.", "Note that as in FIG.", "3D, the gate of the transistor 104 can be connected to the wiring 121 in FIGS.", "3A to 3C.", "Note that as shown in FIG.", "3E, the second terminal of the transistor 103 can be connected to the wiring 121.Since the second terminal of the transistor 103 is connected to the wiring 121, the voltage V1 is supplied from the wiring 122A to the wiring 121 during the period T4; therefore, the potential of the wiring 121 easily maintained as V1.Note that as in FIG.", "3E, the second terminal of the transistor 103 can be connected to the wiring 121 in FIGS.", "3A to 3D.", "Note that as shown in FIG.", "4A, the capacitor 105 can be eliminated.", "In that case, the parasitic capacitance between the gate and the second terminal of the transistor 101 can be used as the capacitor 105.Note that in FIG.", "4A, in the case where the parasitic capacitance between the gate and the second terminal of the transistor 101 is used as the capacitor 105, the parasitic capacitance between the gate and the second terminal of the transistor 101 is preferably higher than the parasitic capacitance between the gate and the first terminal of the transistor 101.Accordingly, in the transistor 101, an area where a conductive layer which functions as a gate electrode and a conductive layer which functions as a source electrode or drain electrode overlap with each other on the second terminal side is preferably larger than that on the first terminal side.", "However, this embodiment is not limited to this.", "Note that as in FIG.", "4A, the capacitor 105 can be eliminated in FIGS.", "3A to 3E.", "Note that as shown in FIG.", "4B, a MOS capacitor can be used as the capacitor 105.In an example in FIG.", "4B, a transistor 105a is used as the capacitor 105.The transistor 105a is an n-channel transistor.", "A first terminal and a second terminal of the transistor 105a are connected to the wiring 121.A gate of the transistor 105a is connected to the node A.", "In this manner, since the potential of the node A is high during a period in which the transistor 105a needs to function as a capacitor (such a period is the periods T1 and T2), the gate capacitance of the transistor 105a can be high.", "On the other hand, since the potential of the node A is low during a period in which the transistor 105a does not need to function as a capacitor (such a period is the periods T3, T4, and T5), the gate capacitance of the transistor 105a can be low.", "However, this embodiment is not limited to this.", "The transistor 105a can be a p-channel transistor.", "Alternatively, one of the first terminal and the second terminal of the transistor 105a can be in a floating state.", "Alternatively, the gate of the transistor 105a can be connected to the wiring 121.The first terminal and the second terminal of the transistor 105a can be connected to the node A. Alternatively, an impurity can be added to a channel region of the transistor 105a.", "Note that as in FIG.", "4B, the transistor 105a can be used as the capacitor 105, the first terminal and the second terminal of the transistor 105a can be connected to the wiring 121, and the gate of the transistor 105a can be connected to the node A in FIGS.", "3A to 3E and FIG.", "4A.", "Note that as shown in FIG.", "4C, a MOS capacitor can be used as the capacitor 106.In an example in FIG.", "4C, a transistor 106a is used as the capacitor 106.The transistor 106a is an n-channel transistor.", "A first terminal and a second terminal of the transistor 106a are connected to the node B.", "A gate of the transistor 106a is connected to the wiring 123A.", "However, this embodiment is not limited to this.", "The transistor 106a can be a p-channel transistor.", "Alternatively, one of the first terminal and the second terminal of the transistor 106a can be in a floating state.", "Alternatively, the gate of the transistor 106a can be connected to the node B.", "The first terminal and the second terminal of the transistor 106a can be connected to the wiring 123A.", "Alternatively, an impurity can be added to a channel region of the transistor 106a.", "Note that as in FIG.", "4C, the transistor 106a can be used as the capacitor 106, the first terminal and the second terminal of the transistor 106a can be connected to the node B, and the gate of the transistor 106a can be connected to the wiring 123A in FIGS.", "3A to 3E and FIGS.", "4A and 4B.", "Note that as shown in FIG.", "4D, the transistor 103 can be replaced with a diode 103a.", "The diode 103a corresponds to the transistor 103.In addition, the diode 103a has a function of decreasing the potential of the node A when the potential of the node B is lower than that of the node A, and a function of bringing the node A and the node B out of electrical conduction when the potential of the node B is higher than that of the node A.", "One terminal (hereinafter also referred to as an input terminal or an anode) of the diode 103a is connected to the node A.", "The other terminal (hereinafter also referred to as an output terminal or a cathode) of the diode 103a is connected to the node B.", "Note that in the case where the transistor 103 is replaced with the diode 103a in FIG.", "4D, voltage V2 can be supplied to the wiring 122B.", "Alternatively, an inverted signal (e.g., an inverted clock signal) of the signal S2 can be input to the wiring 123A.", "Note that as in FIG.", "4D, the transistor 103 can be replaced with the diode 103a, one terminal of the diode 103a can be connected to the node A, and the other terminal of the diode 103a can be connected to the node B in FIGS.", "3A to 3E and FIGS.", "4A to 4C.", "Note that as shown in FIG.", "4E, the transistor 104 can be replaced with a diode 104a.", "In FIG.", "4E, an example of the case where not only the transistor 104 but also the transistor 103 is replaced with a diode is shown.", "The diode 104a corresponds to the transistor 104.In addition, the diode 104a has a function of raising the potential of the node B when the potential of the node A is higher than that of the node B, and a function of bringing the node A and the node B out of electrical conduction when the potential of the node A is lower than that of the node B.", "One terminal of the diode 104a is connected to the node A.", "The other terminal of the diode 104a is connected to the node B.", "Note that as in FIG.", "4E, the transistor 104 can be replaced with the diode 104a, one terminal of the diode 104a can be connected to the node A, and the other terminal of the diode 104a can be connected to the node B in FIGS.", "3A to 3E and FIGS.", "4A to 4D.", "Note that as shown in FIG.", "4F, a diode-connected transistor can be used as a diode.", "The diode-connected transistor 103 and the diode-connected transistor 104 correspond to the diode 103a and the diode 104a, respectively.", "The first terminal of the transistor 103 is connected to the node B.", "The second terminal and the gate of the transistor 103 are connected to the node A.", "The first terminal and the gate of the transistor 104 are connected to the node A.", "The second terminal of the transistor 104 is connected to the node B.", "However, this embodiment is not limited to this.", "The gate of the transistor 103 can be connected to the node B and the gate of the transistor 104 can be connected to the node B.", "Note that as in FIG.", "4F, the first terminal of the transistor 103 can be connected to the node B, the second terminal of the transistor 103 can be connected to the node A, and the gate of the transistor 103 can be connected to the node A in FIGS.", "3A to 3E and FIGS.", "4A to 4E.", "Alternatively, the first terminal of the transistor 104 can be connected to the node A, the second terminal of the transistor 104 can be connected to the node B, and the gate of the transistor 104 can be connected to the node A.", "However, this embodiment is not limited to this.", "The gate of the transistor 103 can be connected to the node B and the gate of the transistor 104 can be connected to the node B.", "Note that as shown in FIG.", "5A, a diode 107 can be additionally provided.", "The diode 107 has a function of decreasing the potential of the node B when a signal in an L level is input to the wiring 123A and a function of bringing the wiring 123A and the node B out of electrical conduction when a signal in an H level is input to the wiring 123A.", "One terminal of the diode 107 is connected to the node B.", "The other terminal of the diode 107 is connected to the wiring 123A.", "However, this embodiment is not limited to this.", "The other terminal of the diode 107 can be connected to a different wiring from the wiring 123A.", "Note that as in FIG.", "5A, the diode 107 can be additionally provided, one terminal of the diode 107 can be connected to the node B, and the other terminal of the diode 107 can be connected to the wiring 123A in FIGS.", "3A to 3E and FIGS.", "4A to 4F.", "Note that as shown in FIG.", "5B, a diode-connected transistor 107a can be additionally provided.", "The diode-connected transistor 107a corresponds to the diode 107 and is an n-channel transistor.", "A first terminal of the transistor 107a is connected to the wiring 123A.", "A second terminal and a gate of the transistor 107a are connected to the node B.", "However, this embodiment is not limited to this.", "The transistor 107a can be a p-channel transistor.", "Alternatively, the gate of the transistor 107a can be connected to the wiring 123A.", "Note that as in FIG.", "5B, the transistor 107a can be additionally provided, the first terminal of the transistor 107a can be connected to the wiring 123A, and the second terminal and the gate of the transistor 107a can be connected to the node B in FIGS.", "3A to 3E, FIGS.", "4A to 4F, and FIG.", "5A.", "However, this embodiment is not limited to this.", "The gate of the transistor 107a can be connected to the node B.", "Note that as shown in FIG.", "5C, the transistor 102 can be eliminated.", "Note that as in FIG.", "5C, the transistor 102 can be eliminated in FIGS.", "3A to 3E, FIGS.", "4A to 4F, and FIGS.", "5A and 5B.", "Note that as shown in FIG.", "5D, the circuit 100 can be eliminated.", "Note that as in FIG.", "5D, the circuit 100 can be omitted in FIGS.", "3A to 3E, FIGS.", "4A to 4F, and FIGS.", "5A to 5C.", "Note that as shown in FIG.", "5E, the transistor 101, the transistor 102, the transistor 103, and the transistor 104 can be replaced with a transistor 101p, a transistor 102p, a transistor 103p, and a transistor 104p, respectively.", "The transistors 101p to 104p correspond to the transistors 101 to 104, respectively, and are p-channel transistors.", "Note that in FIG.", "5E, a relation of potential is opposite to that in the semiconductor device in FIG.", "1A in many cases.", "For example, the voltage V2 can be supplied to the wirings 122A and 122B and an inverted signal of the signal S2 can be input to the wirings 123A and 123B.", "Similarly, an inverted signal of the signal S1 is output from the wiring 121 in many cases.", "Note that in FIG.", "5E, the circuit 100 has a function of decreasing the potential of the node A during the period T1 in many cases.", "Alternatively, the circuit 100 has a function of raising the potential of the node A to V2 during the period T3 in many cases.", "Note that as in FIG.", "5E, p-channel transistors can be used as the transistors 101 to 104 in FIGS.", "3A to 3E, FIGS.", "4A to 4F, and FIGS.", "5A to 5D.", "Embodiment 2 In this embodiment, one example of the semiconductor device will be described.", "The semiconductor device of this embodiment is a specific example of the semiconductor device described in Embodiment 1.In specific, a specific example of the circuit 100 will be described in this embodiment.", "Note that the content described in Embodiment 1 can be applied to the semiconductor device in this embodiment.", "The specific example of the circuit 100 will be explained with reference to FIG.", "6A.", "However, FIG.", "6A is one example and this embodiment is not limited to this.", "Circuits of a variety of structures can be used as the circuit 100 besides the circuit with the structure shown in FIG.", "6A.", "Note that a portion which is similar to that in FIG.", "1A is denoted by the same reference numeral and the description thereof is omitted.", "The circuit 100 includes a transistor 131, a transistor 132, a transistor 133, a transistor 134, and a transistor 135.Each of the transistors 131 to 135 is an n-channel transistor.", "However, each of the transistors 131 to 135 can be a p-channel transistor.", "A connection relation of the transistors included in the circuit 100 will be described.", "A first terminal of the transistor 131 is connected to a wiring 125.A second terminal of the transistor 131 is connected to the node A.", "A gate of the transistor 131 is connected to the wiring 125.A first terminal of the transistor 132 is connected to the wiring 125.A second terminal of the transistor 132 is connected to the node A.", "A gate of the transistor 132 is connected to the wiring 124A.", "A first terminal of the transistor 133 is connected to a wiring 122E.", "A second terminal of the transistor 133 is connected to the wiring 121.A gate of the transistor 133 is connected to a wiring 124B.", "A first terminal of the transistor 134 is connected to a wiring 122C.", "A second terminal of the transistor 134 is connected to the node A.", "A gate of the transistor 134 is connected to the wiring 126.A first terminal of the transistor 135 is connected to a wiring 122D.", "A second terminal of the transistor 135 is connected to the wiring 121.A gate of the transistor 135 is connected to the wiring 126.An example of a thing (e.g., a signal, voltage, or current) which can be input to the wirings 122C to 122E, the wirings 124A and 124B, the wiring 125, and the wiring 126 will be described.", "However, the content described below is one example and this embodiment is not limited to this.", "A variety of things besides that described below can be input to each wiring.", "In addition, each wiring can be made in a floating state.", "Like the wirings 122A and 122B, the voltage V1 is supplied to the wirings 122C to 122E.", "Accordingly, the wirings 122C to 122E can function as power supply lines.", "However, this embodiment is not limited to this.", "A signal such as a clock signal can be input to the wirings 122C to 122E.", "In that case, the wirings 122C to 122E can function as signal lines.", "Alternatively, different voltages can be supplied to the wirings 122C to 122E.", "For example, a signal S3 is input to the wirings 124A and 124B.", "Accordingly, the wirings 124A and 124B can function as signal lines.", "The signal S3 is an inverted signal of the signal S2 or a signal which is out of phase with the signal S2 by approximately 180° in many cases and can function as an inverted clock signal (CKB).", "However, this embodiment is not limited to this.", "Voltage can be supplied to the wirings 124A and 124B.", "In that case, the wirings 124A and 124B can function as power supply lines.", "Alternatively, different signals can be input to the wirings 124A and 124B.", "For example, a signal S4 is input to the wiring 125.Accordingly, the wiring 125 can function as a signal line.", "The signal S4 is a digital signal with an L level and an H level in many cases and can function as a start signal (SP), a transfer signal from a different row (stage), or a signal for selecting a different row.", "However, this embodiment is not limited to this.", "Voltage can be supplied to the wiring 125.In that case, the wiring 125 can function as a power supply line.", "For example, a signal S5 is input to the wiring 126.Accordingly, the wiring 126 can function as a signal line.", "The signal S5 is a digital signal with an L level or an H level in many cases and can function as a reset signal (RE) or a signal for selecting a different row.", "However, this embodiment is not limited to this.", "Voltage can be supplied to the wiring 126.In that case, the wiring 126 can function as a power supply line.", "One example of functions of the transistors 131 to 135 will be described.", "However, the content described below is one example and this embodiment is not limited to this.", "The transistors 131 to 135 can have a variety of functions besides that described below.", "Alternatively, it is possible that the transistors 131 to 135 do not have the functions described below.", "The transistor 131 has a function of raising the potential of the node A in accordance with a signal (e.g., the signal S4) input to the wiring 125 and functions as a diode.", "The transistor 132 has a function of controlling a timing when the wiring 125 and the node A are brought into electrical conduction in accordance with a signal (e.g., the signal S3) input to the wiring 124A and functions as a switch.", "The transistor 133 has a function of controlling a timing when the wiring 122E and the wiring 121 are brought into electrical conduction in accordance with a signal (e.g., the signal S3) input to the wiring 124B and functions as a switch.", "The transistor 134 has a function of controlling a timing when the wiring 122C and the node A are brought into electrical conduction in accordance with a signal (e.g., the signal S5) input to the wiring 126 and functions as a switch.", "The transistor 135 has a function of controlling a timing when the wiring 122D and the wiring 121 are brought into electrical conduction in accordance with a signal (e.g., the signal S5) input to the wiring 126 and functions as a switch.", "Next, operation of the semiconductor device in FIG.", "6A will be described with reference to FIG.", "6B, FIGS.", "7A to 7C, and FIGS.", "8A and 8B.", "FIG.", "6B is one example of a timing chart for illustrating the operation of the semiconductor device and there are a period T1, a period T2, a period T3, a period T4, and a period T5.FIG.", "7A is a schematic view of the operation of the semiconductor device in FIG.", "6A during the period T1.FIG.", "7B is a schematic view of the operation of the semiconductor device in FIG.", "6A during the period T2.FIG.", "7C is a schematic view of the operation of the semiconductor device in FIG.", "6A during the period T3.FIG.", "8A is a schematic view of the operation of the semiconductor device in FIG.", "6A during the period T4.FIG.", "8B is a schematic view of the operation of the semiconductor device in FIG.", "6A during the period T5.Note that description of operation in common with the semiconductor device in FIG.", "1A is omitted.", "First, during the period T1, since the signal S5 is in an L level, the transistor 134 and the transistor 135 are turned off.", "Accordingly, the wiring 122C and the node A are brought out of electrical conduction and the wiring 122D and the wiring 121 are brought out of electrical conduction.", "At the same time, since the signal S3 and the signal S4 are made to be in an H level, the transistor 131, the transistor 132, and the transistor 133 are turned on.", "Then, the wiring 125 and the node A are brought into electrical conduction and the wiring 122E and the wiring 121 are brought into electrical conduction.", "Accordingly, the signal (the signal S4 in the H level) input to the wiring 125 is supplied from the wiring 125 to the node A, whereby the potential of the node A starts to be raised.", "Further, since the wiring 122E and the wiring 121 are brought into electrical conduction, the voltage V1 is supplied from the wiring 122E to the wiring 121.After that, when the potential of the node A is raised to a value obtained by subtracting the threshold voltage (Vth131) of the transistor 131 from the potential (V2) in the H level of the signal S4, (V2−Vth131), the transistor 131 is turned off.", "Similarly, when the potential of the node A is raised to a value obtained by subtracting the threshold voltage (Vth132) of the transistor 132 from the potential (V2) in the H level of the signal S3, (V2−Vth132), the transistor 132 is turned off.", "When the transistor 131 and the transistor 132 are off, charge is not supplied to the node A.", "Accordingly, the potential of the node A is maintained as a large value (at least greater than or equal to V1+Vth101) and the node A goes into a floating state.", "Here, for simplicity, the transistor 131 and the transistor 132 are turned off when the potential of the node A becomes (V2−Vth131).", "Accordingly, the wiring 125 and the node A are brought out of electrical conduction.", "The potential of the node A at that time is maintained as (V1−Vth131) and the node A goes into a floating state.", "Next, during the period T2, since the signal S4 is in an L level, the transistor 131 is kept off.", "Then, since the signal S3 goes into an L level, the transistor 132 is kept off and the transistor 133 is turned off.", "Accordingly, the wiring 125 and the node A are kept out of electrical conduction and the wiring 122E and the wiring 121 are brought out of electrical conduction.", "At that time since the signal S5 is kept in the L level, the transistor 134 and the transistor 135 are kept off.", "Accordingly, the wiring 122C and the node A are kept out of electrical conduction and the wiring 122D and the wiring 121 are kept out of electrical conduction.", "Next, during the period T3, since the signal S4 is kept in the L level, the transistor 131 is kept off.", "Then, since the signal S5 goes into an H level, the transistor 134 and the transistor 135 are turned on.", "Accordingly, the wiring 122C and the node A are brought into electrical conduction and the wiring 122D and the wiring 121 are brought into electrical conduction.", "Accordingly, since the voltage V1 is supplied from the wiring 122C to the node A, the potential of the node A is decreased to V1.Similarly, since the voltage V1 is supplied from the wiring 122D to the wiring 121, the potential of the wiring 121 is decreased to V1.At the same time, since the signal S3 goes into an H level, the transistor 132 and the transistor 133 are turned on.", "Thus, the wiring 125 and the node A are brought into electrical conduction and the wiring 122E and the wiring 121 are brought into electrical conduction.", "Accordingly, since the signal S4 in the L level is supplied to the node A, the potential of the node A is decreased to V1.Similarly, since the voltage V1 is supplied to the wiring 121, the potential of the wiring 121 is decreased to V1.Next, during the period T4, since the signal S4 is kept in the L level, the transistor 131 is kept off.", "Then, since the signal S5 goes into an L level, the transistor 134 and the transistor 135 are turned off.", "Accordingly, the wiring 122C and the node A are brought out of electrical conduction and the wiring 122D and the wiring 121 are brought out of electrical conduction.", "At that time, since the signal S4 goes into an L level, the transistor 132 and the transistor 133 are turned off.", "Accordingly, the wiring 125 and the node A are brought out of electrical conduction and the wiring 122E and the wiring 121 are brought out of electrical conduction.", "Next, during the period T5, since the signal S4 is kept in the L level, the transistor 131 is kept off.", "Then, since the signal S5 is kept in the L level, the transistor 134 and the transistor 135 are kept off.", "Accordingly, the wiring 122C and the node A are kept out of electrical conduction and the wiring 122D and the wiring 121 are kept out of electrical conduction.", "At that time, since the signal S3 goes into an H level, the transistor 132 and the transistor 133 are turned on.", "Accordingly, the wiring 125 and the node A are brought into electrical conduction and the wiring 122E and the wiring 121 are brought into electrical conduction.", "Accordingly, since the signal S4 in the L level is supplied from the wiring 125 to the node A, the potential of the node A is maintained as V1.Similarly, since the voltage V1 is supplied from the wiring 122E to the wiring 121, the potential of the wiring 121 is maintained as V1.In the semiconductor device in FIG.", "6A, since the signal in the L level or the voltage V1 is supplied to the node A during the periods T4 and T5, noise of the node A can be reduced.", "Therefore, malfunction can be prevented.", "Alternatively, in the semiconductor device in FIG.", "6A, since both of the transistor 131 and the transistor 132 are turned on during the period T1, the potential of the node A can be quickly raised.", "Alternatively, the channel width of the transistor 131 or the channel width of the transistor 132 can be made small.", "Note that the channel width of the transistor 131 can be larger than that of the transistor 134 or the transistor 103.Similarly, the channel width of the transistor 132 can be larger than that of the transistor 134 or the transistor 103.This is because the potential of the node A is preferably raised quickly during the period T2 and the potential of the node A is preferably decreased slowly during the period T3.That is, when the potential of the node A is raised quickly during the period T2, increase in driving frequency, suppression of through current, reduction in power consumption, or the like can be achieved.", "On the other hand, when the potential of the node A is decreased slowly during the period T3, an on time of the transistor 101 becomes long, whereby a rising time of a signal (e.g., the signal S1) output from the wiring 121 can be shortened.", "Therefore, the channel width of the transistor that has a function of raising the potential of the node A during the period T2 is preferably larger than that of the transistor that decreases the potential of the node A during the period T3.However, this embodiment is not limited to this.", "The channel width of the transistor 131 can be smaller than that of the transistor 134 or the transistor 103.Similarly, the channel width of the transistor 132 can be smaller than that of the transistor 134 or the transistor 103.Note that the sum of the channel width of the transistor 131 and the channel width of the transistor 134 can be larger than the channel width of the transistor 134 or the channel width of the transistor 103.This is because, during the period T2, the signal S4 in the H level is supplied from the wiring 125 to the node A through two transistors of the transistor 131 and the transistor 132 connected in parallel.", "However, this embodiment is not limited to this.", "The sum of the channel width of the transistor 131 and the channel width of the transistor 134 can be smaller than the channel width of the transistor 134 or the channel width of the transistor 103.Note that the channel width of the transistor 134 can be smaller than that of the transistor 133.Similarly, the channel width of the transistor 132 can be smaller than that of the transistor 133.Similarly, the channel width of the transistor 103 can be smaller than that of the transistor 102.This is because the load (e.g., wiring resistance, parasitic capacitance, a transistor to be connected, or the like) of the wiring 121 is higher than that of the node A in many cases.", "Accordingly, the channel width of a transistor that has a function of supplying a signal or voltage to the node A is preferably smaller than that of a transistor that supplies a signal or voltage to the wiring 121.However, this embodiment is not limited to this.", "The channel width of the transistor 134 can be larger than that of the transistor 133.Similarly, the channel width of the transistor 132 can be larger than that of the transistor 133.Similarly, the channel width of the transistor 103 can be larger than that of the transistor 102.Note that the channel width of the transistor 103 can be larger than that of the transistor 132.This is because the transistor 103 has a function of maintaining the potential of the node A as V1 during the period T4 while the transistor 132 has a function of maintaining the potential of the node A as V1 during the period T5.In specific, a signal (e.g., the signal S2) input to the wiring 123B is in an H level during the period T4.At that time, if the potential of the node A is raised and the transistor 101 is turned on, the potential of the wiring 121 is raised.", "Therefore, since the transistor 103 is required to maintain the potential of the node A as V1 and keep the transistor 101 off, the channel width of the transistor 103 is preferably large.", "On the other hand, since a signal (e.g., the signal S2) input to the wiring 123B is in an L level during the period T5, the potential of the wiring 121 is not raised even if the transistor 101 is turned on.", "That is, even if the potential of the node A is raised or decreased from V1, the potential of the wiring 121 is not raised.", "Therefore, since there is no great necessity for reducing the on resistance of the transistor 132, the channel width of the transistor 132 is preferably small.", "However, this embodiment is not limited to this.", "The channel width of the transistor 103 can be smaller than that of the transistor 132.This is because the transistor 132 has a function of raising the potential of the node A during the period T1.By increasing the channel width of the transistor 132, the potential of the node A can be quickly raised.", "Note that the channel width of the transistor 102 can be smaller than that of the channel width of the transistor 133.This is because, if the channel width of the transistor 102 is too large, the potential of the node A decreases too much during the period T2, whereby the semiconductor device malfunctions.", "In specific, both of the transistor 102 and the transistor 133 have a function of maintaining the potential of the wiring 121 as V1.However, during the period T2, the transistor 102 is on until the potential of the wiring 121 is raised to a value obtained by subtracting the threshold voltage (Vth102) of the transistor 102 from the potential (V2) of the wiring 123C, (V2−Vth102).", "Therefore, in order to prevent the potential of the node A from decreasing too much during the period T2, the channel width of the transistor 102 is preferably small.", "On the other hand, the channel width of the transistor 133 is preferably large in order to maintain the potential of the wiring 121 as V1.However, this embodiment is not limited to this.", "The channel width of the transistor 102 can be larger than that of the transistor 133.This is because there is a high possibility that the potential of the wiring 121 is raised when the signal S2 goes into an H level during the period T4.Therefore, by increasing the channel width of the transistor 102, rise of the potential of the wiring 121 can be easily suppressed.", "Note that as in Embodiment 1, the potential of the signal in the L level which is input to the wiring 124A, the wiring 124B, the wiring 125, and/or the wiring 126 can be lower than V1.In specific, since a period of time when the transistor 132 and the transistor 133 are on is long, the potential of the signal in the L level which is input to the wiring 124A and the wiring 124B is preferably lower than V1.Note that as in Embodiment 1, the potential of the signal in the H level which is input to the wiring 124A, the wiring 124B, the wiring 125, and/or the wiring 126 can be lower than V2.In specific, since the transistor 132 and the transistor 133 easily deteriorate, the potential of the signal in the H level which is input to the wiring 124A and the wiring 124B is preferably lower than V2.Note that as in Embodiment 1, a signal can be input to the wiring 122C, the wiring 122D, or the wiring 122E.", "For example, a signal which goes into an L level during a period (e.g., the period T3) in which the transistor 134 is on can be input to the wiring 122C.", "For example, the signal S2 or the signal S4 can be given as the signal.", "A signal which goes into an L level during a period (e.g., the period T3) in which the transistor 135 is on can be input to the wiring 122D.", "For example, the signal S2 or the signal S4 can be given as the signal.", "A signal which goes into an L level during a period (e.g., the period T1, the period T3, and the period T5) in which the transistor 133 is on can be input to the wiring 122E.", "For example, the signal S2 or the signal S3 can be given as the signal.", "Note that FIG.", "13C shows a structure in which the first terminal of the transistor 103 is connected to the wiring 124B, the first terminal of the transistor 104 is connected to the wiring 126, the first terminal of the transistor 133 is connected to the wiring 123A, the first terminal of the transistor 134 is connected to the wiring 123A, and the first terminal of the transistor 135 is connected to the wiring 123A, for example.", "However, this embodiment is not limited to this.", "The first terminal of the transistor 103 can be connected to the wiring 124A or the wiring 125.Alternatively, the first terminal of the transistor 133, the first terminal of the transistor 134, or the first terminal of the transistor 135 can be connected to the wiring 121, the wiring 123B, the wiring 123C, or the wiring 126.Note that as in Embodiment 1, voltage (e.g., the voltage V1 or the voltage V2) can be supplied to the wiring 124A, the wiring 124B and/or the wiring 126.In this manner, the semiconductor device can function as an inverter circuit or a buffer circuit.", "Note that as shown in FIG.", "9A, since the same signal (e.g., the signal S3) is input to the wiring 124A and the wiring 124B, the wiring 124A and the wiring 124B can be shared.", "Accordingly, the gate of the transistor 132 and the gate of the transistor 133 are connected to the wiring 124.The wiring 124 corresponds to the wiring 124A or the wiring 124B.", "A signal similar to that input to these wirings can be input to the wiring 124.Note that FIG.", "9C shows a structure in which FIG.", "3C and FIG.", "9A are combined.", "For example, the first terminal of the transistor 101, the gate of the transistor 102, and one electrode of the capacitor 106 are connected to the wiring 123.The gate of the transistor 132 and the gate of the transistor 133 are connected to the wiring 124.The first terminal of the transistor 103, the first terminal of the transistor 104, the first terminal of the transistor 133, the first terminal of the transistor 134, and the first terminal of the transistor 135 are connected to the wiring 122.Note that as shown in FIG.", "9C, the gate of the transistor 131 can be connected to the wiring 127.For example, the voltage V2 is supplied to the wiring 127 and the wiring 127 can function as a power supply line.", "However, this embodiment is not limited to this.", "A variety of things such as current, voltage, or a signal can be input to the wiring 127.For example, since a signal that is input to the wiring 127 is preferably in an H level during the period T1 and is in an L level during the period T2, the signal S3 can be input to the wiring 127.In that case, the wiring 127 can be connected to the wiring 124A or the wiring 124B and function as a signal line.", "Note that in FIG.", "9C, although the gate of the transistor 131 is connected to the wiring 127, this embodiment is not limited to this.", "For example, the first terminal of the transistor 131 can be connected to the wiring 127 and the gate of the transistor 131 can be connected to the wiring 125.Note that as in FIG.", "9C, the gate of the transistor 131 can be connected to the wiring 127 in FIGS.", "9A and 9B.", "Note that as shown in FIG.", "10A, the transistor 131 can be eliminated.", "Even though the transistor 131 is eliminated, the potential of the node A is raised because the transistor 132 is on during the period T1.Note that as in FIG.", "10A, the transistor 131 can be eliminated in FIGS.", "9A to 9C.", "Note that as shown in FIG.", "10B, the transistor 132 can be eliminated.", "Even though the transistor 132 is eliminated, the potential of the node A is maintained as V1 because the node A goes into a floating state in the period T5.Note that as in FIG.", "10B, the transistor 132 can be eliminated in FIGS.", "9A to 9C and FIG.", "10A.", "Note that as shown in FIG.", "10C, the transistor 134 and the transistor 135 can be eliminated.", "Alternatively, one of the transistor 134 and the transistor 135 can be eliminated.", "Even though the transistor 134 is eliminated, the potential of the node A is decreased to V1 because the transistor 132 is turned on in the period T3.Similarly, even though the transistor 135 is eliminated, the potential of the wiring 121 is decreased to V1 because the transistor 133 is turned on in the period T3.Note that as in FIG.", "10C, the transistor 134 and the transistor 135 can be eliminated in FIGS.", "9A to 9C and FIGS.", "10A and 10B.", "Note that as shown in FIG.", "11A, the transistor 133 can be eliminated.", "Even though the transistor 133 is eliminated, the potential of the wiring 121 is maintained as V1 because the wiring 121 goes into a floating state in the period T5.Note that as in FIG.", "11A, the transistor 133 can be eliminated in FIGS.", "9A to 9C and FIGS.", "10A to 10C.", "Note that as shown in FIG.", "11B, the transistor 102 can be eliminated.", "Even though the transistor 102 is eliminated, the potential of the wiring 121 is maintained as V1 because the wiring 121 goes into a floating state in the period T4.Note that as in FIG.", "11B, the transistor 102 can be eliminated in FIGS.", "9A to 9C, FIGS.", "10A to 10C, and FIG.", "11A.", "Note that as shown in FIG.", "11C, the transistor 103, the transistor 104, and the capacitor 106 can be eliminated.", "Even though the transistor 103, the transistor 104, and the capacitor 106 are eliminated, the potential of the wiring 121 is maintained as V1 because the wiring 121 goes into a floating state in the period T4.Note that as in FIG.", "11C, the transistor 103, the transistor 104, and the capacitor 106 can be eliminated in FIGS.", "9A to 9C, FIGS.", "10A to 10C, and FIGS.", "11A and 11B.", "Note that as shown in FIG.", "12A, the transistor 133 can be replaced with a diode 133a.", "The diode 133a corresponds to the transistor 133.The diode 133a has a function of decreasing the potential of the wiring 121 when a signal in an L level is input to the wiring 124B, and a function of bringing the wiring 124B and the wiring 121 out of electrical conduction when a signal in an H level is input to the wiring 124B.", "One terminal (hereinafter referred to as an input terminal or an anode) of the diode 133a is connected to the wiring 121.The other terminal (hereinafter referred to as an output terminal or a cathode) of the diode 133a is connected to the wiring 124B.", "Note that in FIG.", "12A, in the case where the transistor 133 is replaced with the diode 133a, the signal S2 can be input to the wiring 124B.", "Therefore, the wiring 124B can be connected to the wirings 123A to 123C and the wiring 124B and the wirings 123A to 123C can be shared.", "Note that as in FIG.", "12A, the transistor 133 can be replaced with the diode 133a, one terminal of the diode 133a can be connected to the wiring 121, and the other terminal of the diode 133a can be connected to the wiring 124B in FIGS.", "9A to 9C, FIGS.", "10A to 10C, and FIGS.", "11A to 11C.", "Note that as shown in FIG.", "12B, the transistor 133 can be diode-connected.", "The diode-connected transistor 133 corresponds to the diode 133a.", "The first terminal of the transistor 133 is connected to the wiring 124B.", "The second terminal of the transistor 133 is connected to the wiring 121.The gate of the transistor 133 is connected to the wiring 121.However, this embodiment is not limited to this.", "The gate of the transistor 133 can be connected to the wiring 124B.", "Note that as in FIG.", "12B, the first terminal of the transistor 133 can be connected to the wiring 124B, the second terminal of the transistor 133 can be connected to the wiring 121, and the gate of the transistor 133 can be connected to the wiring 121 in FIGS.", "9A to 9C, FIGS.", "10A to 10C, FIGS.", "11A to 11C, and FIG.", "12A.", "However, this embodiment is not limited to this.", "The gate of the transistor 133 can be connected to the wiring 124B.", "Note that as shown in FIG.", "12C, the transistor 134 can be replaced with a diode 134a, and the transistor 135 can be replaced with a diode 135a.", "The diode 134a and the diode 135a correspond to the transistor 134 and the transistor 135, respectively.", "The diode 134a has a function of decreasing the potential of the node A when a signal in an L level is input to the wiring 126, and a function of bringing the wiring 126 and the node A out of electrical conduction when a signal in an H level is input to the wiring 126.The diode 135a has a function of decreasing the potential of the wiring 121 when a signal in an L level is input to the wiring 126, and a function of bringing the wiring 126 and the wiring 121 out of electrical conduction when a signal in an H level is input to the wiring 126.One terminal (hereinafter referred to as an input terminal or an anode) of the diode 134a is connected to the node A.", "The other terminal (hereinafter referred to as an output terminal or a cathode) of the diode 134a is connected to the wiring 126.One terminal (hereinafter referred to as an input terminal or an anode) of the diode 135a is connected to the wiring 121.The other terminal (hereinafter referred to as an output terminal or a cathode) of the diode 135a is connected to the wiring 126.Note that in the case where the transistor 134 and the transistor 135 are replaced with diodes in FIG.", "12C, an inverted signal of the signal S5 can be input to the wiring 126, for example.", "Note that in FIG.", "12C, only one of the transistor 134 and the transistor 135 can be replaced with a diode.", "Note that as in FIG.", "12C, the transistor 134 can be replaced with the diode 134a, one terminal of the diode 134a can be connected to the node A, and the other terminal of the diode 134a can be connected to the wiring 126 in FIGS.", "9A to 9C, FIGS.", "10A to 10C, FIGS.", "11A to 11C, and FIGS.", "12A and 12B.", "Alternatively, the transistor 135 can be replaced with the diode 135a, one terminal of the diode 135a can be connected to the wiring 121, and the other terminal of the diode 135a can be connected to the wiring 126.Note that as shown in FIG.", "13A, the transistor 134 and the transistor 135 can be diode-connected.", "The diode-connected transistor 134 and the diode-connected transistor 135 correspond to the diode 134a and the diode 135a, respectively.", "The first terminal of the transistor 134 is connected to the wiring 126.The second terminal of the transistor 134 is connected to the node A.", "The gate of the transistor 134 is connected to the node A.", "The first terminal of the transistor 135 is connected to the wiring 126.The second terminal of the transistor 135 is connected to the wiring 121.The gate of the transistor 135 is connected to the wiring 121.However, this embodiment is not limited to this.", "The gate of the transistor 134 can be connected to the wiring 126.The gate of the transistor 135 can be connected to the wiring 126.Note that as in FIG.", "13A, the first terminal of the transistor 134 can be connected to the wiring 126, the second terminal of the transistor 134 can be connected to the node A, and the gate of the transistor 134 can be connected to the node A in FIGS.", "9A to 9C, FIGS.", "10A to 10C, FIGS.", "11A to 11C, and FIGS.", "12A to 12C.", "Alternatively, the first terminal of the transistor 135 can be connected to the wiring 126, the second terminal of the transistor 135 can be connected to the wiring 121, and the gate of the transistor 135 can be connected to the wiring 121.However, this embodiment is not limited to this.", "The gate of the transistor 134 can be connected to the wiring 126.The gate of the transistor 135 can be connected to the wiring 126.Note that as shown in FIG.", "13B, a transistor 137 and a transistor 138 can be additionally provided.", "The transistor 137 and the transistor 138 are n-channel transistors.", "However, this embodiment is not limited to this.", "The transistor 137 and the transistor 138 can be p-channel transistors.", "A first terminal of the transistor 137 is connected to the wiring 122F.", "A second terminal of the transistor 137 is connected to the wiring 121.A gate of the transistor 137 is connected to the wiring 128.A first terminal of the transistor 138 is connected to the wiring 1220.A second terminal of the transistor 138 is connected to the node A.", "A gate of the transistor 138 is connected to the wiring 128.For example, a signal S6 is input to the wiring 128.Therefore, the wiring 128 can function as a signal line.", "The signal S6 is a digital signal with an H level and an L level in many cases.", "For example, the signal S6 can function as a signal which resets all the stages.", "For example, the voltage V1 is supplied to the wiring 122F and the wiring 122G.", "Therefore, the wiring 122F and the wiring 122G can function as power supply lines.", "Accordingly, the wirings 122A to 122G can be shared.", "In that case, the first terminal of the transistor 137 and the first terminal of the transistor 138 can be connected to the wiring 122 as shown in FIG.", "11B.", "However, a variety of things such as current, voltage, or signal can be input to the wiring 128, the wiring 122F, and the wiring 122G.", "Note that in FIG.", "13B, the signal S6 can be in an H level during a period before a semiconductor device starts to operate.", "Alternatively, in the case where a semiconductor device shown in FIG.", "13B is used as a shift register, the signal S6 can be in an H level during a period before the shift register starts to scan or a period after the shift register has completed the scanning.", "Therefore, as the signal S6, a start pulse of the shift register, an output signal from the lowest stage of the shift register, or the like can be used.", "However, one example of this embodiment is not limited to this.", "Note that in FIG.", "13B, only one of the transistor 137 and the transistor 138 can be additionally provided.", "Note that as in FIG.", "13B, the transistor 137 can be additionally provided, the first terminal of the transistor 137 can be connected to the wiring 122F, the second terminal of the transistor 137 can be connected to the wiring 121, and the gate of the transistor 137 can be connected to the wiring 128 in FIGS.", "9A to 9C.", "FIGS.", "10A to 10C, FIGS.", "11A to 11C, FIGS.", "12A to 12C, and FIG.", "13A.", "Alternatively, the transistor 138 can be additionally provided, the first terminal of the transistor 138 can be connected to the wiring 122G, the second terminal of the transistor 138 can be connected to the node A, and the gate of the transistor 138 can be connected to the wiring 128.Embodiment 3 In this embodiment, one example of a shift register is described.", "The shift register in this embodiment can include the semiconductor device of Embodiment 1 and Embodiment 2.Note that the shift register can also be referred to as a semiconductor device or a gate driver.", "Note that the content described in Embodiment 1 and Embodiment 2 can be applied to that of the shift register in this embodiment.", "First, one example of the shift register will be described with reference to FIG.", "14A.", "A shift register 220 is connected to wirings 201_1 to 201_N (N is a natural number), a wiring 202, a wiring 203, a wiring 204, a wiring 205, and a wiring 206.The wiring 202 corresponds to the wiring 123 (the wirings 123A to 123C) described in Embodiment 1 and Embodiment 2 or the wiring 124 (the wirings 124A and 124B) described in Embodiment 1 and Embodiment 2 and can function as a signal line or a clock signal line.", "In addition, a signal GS2 is input from a circuit 221 to the wiring 202.The signal GS2 corresponds to the signal S2 or the signal S3 described in Embodiment 1 and Embodiment 2 and can function as a clock signal.", "The wiring 203 corresponds to the wiring 123 (the wirings 123A to 123C) described in Embodiment 1 and Embodiment 2 or the wiring 124 (the wirings 124A and 124B) described in Embodiment 1 and Embodiment 2 and can function as a signal line or a clock signal line.", "In addition, a signal GS3 is input from the circuit 221 to the wiring 203.The signal GS3 corresponds to the signal S2 or the signal S3 described in Embodiment 1 and Embodiment 2 and can function as an inverted clock signal.", "The wiring 204 corresponds to the wiring 122 (the wirings 122A to 122G) described in Embodiment 1 and Embodiment 2 and can function as a power supply line.", "In addition, voltage V1 is input from the circuit 221 to the wiring 204.The wiring 205 corresponds to the wiring 125 described in Embodiment 1 and Embodiment 2 and can function as a signal line.", "In addition, a signal GS4 is input from the circuit 221 to the wiring 205.The signal GS4 corresponds to the signal S4 described in Embodiment 1 and Embodiment 2 and can function as a start signal (hereinafter referred to as a start pulse) or a vertical synchronizing signal.", "The wiring 206 corresponds to the wiring 126 described in Embodiment 1 and Embodiment 2 and can function as a signal line.", "In addition, a signal GS5 is input from a circuit 221 to the wiring 206.The signal GS5 corresponds to the signal S5 described in Embodiment 1 and Embodiment 2 and can function as a reset signal.", "However, this embodiment is not limited to the above description.", "A variety of things such as a signal, voltage, or current can be input to the wirings 202 to 206.Each wiring can be in a floating state.", "Note that as shown in FIG.", "6C, an unbalanced clock signal can be used as the signal S2 or the signal S3.In that case, for example, the signal S3 can have a phase which is deviated from that of the S2 by 180°.", "Accordingly, in the case where the semiconductor device of this embodiment is used as a shift register, a selection signal in one stage can be prevented from overlapping with a selection signal in the previous stage or the next stage.", "The wirings 201_1 to 201_N each correspond to the wiring 121 described in Embodiment 1 and Embodiment 2 and can each function as a gate line or a scan line.", "In addition, signals GS1_1 to GS1_N are output from the wirings 201_1 to 201_N, respectively.", "The signals GS1_1 to GS1_N each correspond to the signal S1 described in Embodiment 1 and Embodiment 2 and can each function as an output signal, a selection signal, a scanning signal, or a gate signal.", "Note that as shown in FIG.", "14B, the signals GS1_1 to GS1_N go into an H level in order from the signal GS1_1.For example, the signal GS1_i−1 (i is any one of 1 to N) goes into an H level.", "After that, when the signal GS2 and the signal SG3 are inverted, the signal GS1_i−1 goes into an L level and the signal GS1_i goes into an H level.", "After that, when the signal GS2 and the signal SG3 are inverted again, the signal GS1_i goes into an L level and a signal GS1_i+1 goes into an H level.", "In this manner, the signals GS1_1 to GS1_N sequentially go into an H level.", "In other words, the wirings 201_1 to 201_N are sequentially selected.", "The circuit 221 has a function of supplying a signal, voltage, or the like to the shift register 220 to control the shift register 220 and can function as a control circuit or a controller or the like.", "In this embodiment, the circuit 211 supplies the signal GS2, the signal GS3, the voltage V1, the signal GS4, and the signal GS5 to the wiring 202, the wiring 203, the wiring 204, the wiring 205, and the wiring 206, respectively.", "However, this embodiment is not limited to this.", "The shift register 220 can supply a signal, current, voltage, or the like to a variety of circuits besides these wirings to control these circuits.", "For example, the circuit 221 can supply a signal, voltage, or the like to a signal line driver circuit, a scan line driver circuit, a pixel, and/or the like to control these circuits.", "The circuit 221 includes a circuit 222 and a circuit 223, for example.", "The circuit 222 has a function of generating power supply voltage such as positive power supply voltage, negative power supply voltage, ground voltage, or reference voltage and can function as a power supply circuit or a regulator.", "The circuit 223 has a function of generating a variety of signals such as a clock signal, an inverted clock signal, a start signal, a reset signal, and/or a video signal and can function as a timing generator.", "However, this embodiment is not limited to this.", "The circuit 221 can include a variety of circuits or a variety of elements in addition to the circuit 222 and the circuit 223.For example, the circuit 221 can include an oscillator, a level shifter circuit, an inverter circuit, a buffer circuit, a DA converter circuit, an AD converter circuit, an operational amplifier, a shift register, a look-up table, a coil, a transistor, a capacitor, a resistor, a frequency divider, and/or the like.", "Next, one example of the shift register 220 will be described with reference to FIG.", "15.The shift register in FIG.", "15 includes a plurality of flip-flops of flip-flops 200_1 to 200_N (N is a natural number).", "The flip-flops 200_1 to 200_N each correspond to the semiconductor device described in Embodiment 1 and Embodiment 2.FIG.", "15 shows a structure in which the semiconductor device in FIG.", "9B is used as a flip-flop as an example.", "Connection relations of the shift register are described.", "First, as an example, a connection relation of the flip-flop 200_i is described.", "In the flip-flop 200_i, the wiring 121, the wiring 122, the wiring 123, the wiring 124, the wiring 126, and the wiring 127 are connected to the wiring 201_i, the wiring 204, the wiring 202, the wiring 203, the wiring 201_i−1, and the wiring 201_i+1, respectively.", "However, the wirings to be connected to the wiring 123 and the wiring 124 are switched in a flip-flop of an odd-numbered stage and a flip-flop of an even-numbered stage in many cases.", "For example, if the wiring 123 is connected to the wiring 202 and the wiring 124 is connected to the wiring 203 in the flip-flop of the odd-numbered stage, the wiring 123 is connected to the wiring 203 and the wiring 124 is connected to the wiring 202 in the flip-flop of the even-numbered stage.", "On the other hand, if the wiring 123 is connected to the wiring 203 and the wiring 124 is connected to the wiring 202 in the flip-flop of the odd-numbered stage, the wiring 123 is connected to the wiring 202 and the wiring 124 is connected to the wiring 203 in the flip-flop of the even-numbered stage.", "Note that in the flip-flop 200_1, the wiring 125 is connected to the wiring 205.Note that in the flip-flop 200_N, the wiring 126 is connected to the wiring 206.Next, one example of operation of the shift register shown in FIG.", "15 is described with reference to a timing chart shown in FIG.", "14B.", "Note that description of operation which is the same as that of the semiconductor device described in Embodiment 1 and Embodiment 2 is omitted.", "Operation of the flip-flop 200_i is described.", "First, the signal GS1_i−1 goes into an H level.", "Then, the flip-flop 200_i starts operation in the period T1 and the signal GS1_i goes into an L level.", "After that, the signal GS2 and the signal GS3 are inverted.", "Then, the flip-flop 200_i starts operation in the period T2 and the signal GS1_i goes into an H level.", "The signal GS1_i is input to the flip-flop 200_i−1 as a reset signal and is input to the flip-flop 200_i+1 as a start signal.", "Accordingly, the flip-flop 200_i−1 starts operation in the period T3 and the flip-flop 200_i+1 starts operation in the period T1.After that, the signal GS2 and the signal GS3 are inverted again.", "Then, the flip-flop 200_i+1 starts operation in the period T2 and the signal GS1_i+1 goes into an H level.", "The signal GS1_i+1 is input to the flip-flop 200_i as a reset signal.", "Accordingly, since the flip-flop 200_i starts operation in the period T3, the signal GS1_i goes into an L level.", "After that, until the signal GS1_i−1 goes into an H level again, the flip-flop 200_i repeats the operation in the period T4 and the operation in the period T5 every time the signal GS2 and the signal GS3 are inverted.", "Note that, instead of an output signal from a flip-flop of the previous stage, the signal GS4 is input from an external circuit to the flip-flop 200_1 through the wiring 205.Therefore, when the signal GS4 goes into an H level, the flip-flop 200_1 starts operation in the period T1.Note that, instead of an output signal from a flip-flop of the next stage, the signal GS5 is input from an external circuit to the flip-flop 200_N through the wiring 206.Therefore, when the signal GS5 goes into an H level, the flip-flop 200_N starts operation in the period T3.By using the semiconductor device described in Embodiment 1 and Embodiment 2 as the shift register in this embodiment, a similar advantage as the semiconductor device described in Embodiment 1 and Embodiment 2 can be obtained.", "Note that the wiring 206 can be eliminated.", "In that case, for example, a structure in which the transistor 134 and the transistor 135 which are shown in FIG.", "10C are eliminated can be employed for the flip-flop 200_N.", "Note that in the case where a signal is used instead of the voltage V1 in the flip-flops 200_1 to 200_N, the wiring 204 can be eliminated.", "Note that the signal GS4 can be input to the wiring 206 as in the case of the wiring 205.In that case, by connecting the wiring 206 to the wiring 205, the wiring 205 and the wiring 206 can be shared.", "Alternatively, the signal GS2 can be input to the wiring 206 as in the case of the wiring 202.In that case, by connecting the wiring 206 to the wiring 202, the wiring 206 and the wiring 202 can be shared.", "Further alternatively, the signal GS3 can be input to the wiring 206 as in the wiring 203.In that case, by connecting the wiring 206 to the wiring 203, the wiring 206 and the wiring 203 can be shared.", "Alternatively, the voltage V1 can be input to the wiring 206 as in the case of the wiring 204.In that case, by connecting the wiring 206 to the wiring 204, the wiring 206 and the wiring 204 can be shared.", "Note that in the case where a structure which requires the signal GS6 like that in FIG.", "13B is used for the flip-flops 200_1 to 200_N, a wiring 207 can be added as shown in FIG.", "16.The signal GS6 is input to the wiring 207.The signal GS6 corresponds to the signal S6 described in Embodiment 2 and can function as a reset signal in all stages.", "In addition, the wiring 207 corresponds to the wiring 128 in FIG.", "13B and can function as a signal line.", "However, this embodiment is not limited to this.", "By making the wiring 207 and a different wiring shared, the number of wirings or the number of signals or power supply voltages can be reduced.", "For example, the signal GS4 can be input to the wiring 207 as in the case of the wiring 205.Accordingly, by connecting the wiring 207 to the wiring 205, the wiring 207 and the wiring 205 can be shared.", "Alternatively, the signal GS5 can be input to the wiring 207 as in the case of the wiring 206.Accordingly, by connecting the wiring 207 to the wiring 206, the wiring 207 and the wiring 206 can be shared.", "Alternatively, a signal S1_N, which is an output signal from the flip-flop 200_N, can be input to the wiring 207.Accordingly, by connecting the wiring 207 to the wiring 201_N, the wiring 207 and the wiring 201_N can be shared.", "Note that in the case where a structure which requires the voltage V2 like that in FIG.", "9C is used for the flip-flops 200_1 to 200_N, a wiring can be additionally provided.", "The voltage V2 is supplied to the wiring that is additionally provided.", "In addition, the wiring corresponds to the wiring 127 in FIG.", "9C and can function as a power supply line.", "Note that as described in Embodiment 1 and Embodiment 2, in the case where a signal whose potential in an L level is lower than V1, a signal whose potential in an H level is lower than V2, or a signal whose amplitude voltage is lower than (V2−V1), or the like is input to the flip-flop in order to suppress deterioration of characteristics of the transistor, a wiring can be additionally provided.", "A signal is input to the wiring.", "The wiring can function as a signal line.", "Note that as shown in FIG.", "17A, the shift register can include a circuit 212, a circuit 213, a circuit 214, a circuit 215, and/or a circuit 216.The circuits 212 to 216 each have a function of increasing (or decreasing) the amplitude voltage or input voltage of an input signal and outputting the input signal and can function as a level shifter circuit.", "Alternatively, the circuits 212 to 216 have a function of inverting an input signal and outputting the inverted input signal and can function as an inverter circuit or a buffer circuit.", "The wiring 202 is connected to the flip-flops through the circuit 212.The wiring 203 is connected to the flip-flops through the circuit 213.The wiring 204 is connected to the flip-flops through the circuit 214.The wiring 205 is connected to the flip-flops through the circuit 215.The wiring 206 is connected to the flip-flops through the circuit 216.In this manner, since a signal with low amplitude can be input to the shift register, the driving voltage of an external circuit can be reduced.", "Therefore, reduction in cost, power consumption, or the like of the external circuit can be achieved.", "Note that as shown in FIG.", "17A, the shift register can include any one, two, or more of the circuits 212 to 216.Note that as shown in FIG.", "17B, the shift register can include circuits 211_1 to 211_N.", "The circuits 211_1 to 211_N each have a function of increasing the current capability of an input signal, increasing the amplitude voltage of the input signal, or inverting the input signal, and can function as a buffer circuit, a level shifter circuit, or an inverter circuit.", "The circuits 211_1 to 211_N are connected between the respective flip-flops 200_1 to 200_N and the respective wirings 201_1 to 201_N.", "For example, the circuit 211_i is connected between the flip-flop 200_i and the wiring 201_i.", "Then, the signal GS1_i which is an output signal from the flip-flop 200_i is output from the wiring 201_i through the circuit 211_i.", "In this manner, since the driving voltage of each flip-flop can be made low, reduction in power consumption, suppression of deterioration in characteristics of a transistor, or the like can be achieved.", "Alternatively, since the channel width of a transistor (in specific, the transistor 101) included in each flip-flop can be made small, reduction in a layout area can be achieved.", "Note that in an example shown in FIG.", "17B, the signal GS1_i is input as a reset signal to the flip-flop 200_i−1 through the circuit 211_i.", "Therefore, in the flip-flop 200_i−1, since a period of time when the transistor 101 is on is long during the period T3, falling time of the signal GS_i−1 which is an output signal from the flip-flop 200_i−1 can be shortened.", "On the other hand, the signal GS1_i is input as a start signal to the 200_i+1 without passing through the circuit 211_i.", "Therefore, in the flip-flop 200_i+1, since the potential of the node A can be quickly raised during the period T1, increase in driving frequency can be achieved.", "However, this embodiment is not limited to this.", "The signal GS1_i can be input as a reset signal to the flip-flop 200_i−1 without passing through the circuit 211_i.", "Alternatively, the signal GS1_i can be input as a start signal to the flip-flop 200_i+1 through the circuit 211_i.", "Note that in the shift register shown in FIG.", "14A, the cycles of signals GS1_1 to GS IN are different from each other by half a cycle of the signal S2 or by half a cycle of the signal S3.However, this embodiment is not limited to this.", "The cycles of the signals GS1_1 to GS1_N can be different from each other by ½×M (M is a natural number) of a cycle of the signal S2 or by ½×M of a cycle of the signal S3.That is, a period in which a signal among the signals GS1_1 to GS1_N in one row goes into an H level and a period in which a signal among the signals GS1_1 to GS1_N in a different row goes into an H level can overlap with each other.", "In order to realize this, a clock signal with a phase of 2×M can be input to the shift register.", "A specific example is described with reference to a shift register in FIG.", "24.FIG.", "24 shows only the flip-flops 200_i+1 to 200_i+2M+1.The wirings 123 of the flip-flops 200_i+1 to 200_i+M are connected to wirings 203_1 to 203_M, respectively.", "The wirings 124 of the flip-flops 200_i+1 to 200_i+M are connected to wirings 204_1 to 204_M, respectively.", "The wirings 123 of the flip-flops 200_i+M+1 to 200_i+2M are connected to the wirings 204_1 to 204_M, respectively.", "The wirings 124 of the flip-flops 200_i+M+1 to 200_i+2M are connected to the wirings 203_1 to 203_M, respectively.", "In addition, the wiring 125 of the flip-flop 200_i+1 is connected to the wiring 121 of the flip-flop 200_i.", "The wiring 126 of the flip-flop 200_i+1 is connected to the wiring 121 of the flip-flop 200_i+M+1.Note that the wirings 203_1 to 203_M correspond to the wiring 203.The wirings 204_1 to 204_M correspond to the wiring 204.As shown in FIG.", "25A, signals GS2_1 to GS2_M are input to the wirings 203_1 to 203_M, respectively.", "Signals GS3_1 to GS3_M are input to the wirings 204_1 to 204_M, respectively.", "The signals GS2_1 to GS2_M are M clock signals whose phases are different from each other by ½M of a cycle and correspond to the signal GS2.The signals GS3_1 to GS3_M are inverted signals of the signals GS2_1 to GS2_M and correspond to the signal GS3.In this manner, the cycles of the signals S1_1 to S1_N can be different from that of the signal S2 by ½×M (M is a natural number) of a cycle or different from that of the signal S3 by ½×M of a cycle.", "Note that in FIG.", "24, the wiring 125 of the flip-flop 200_i+1 can be connected the wiring 121 of any one of the flip flops 200_i−M+1 to 200_i−1.In this manner, since a timing when the transistor 131 in the flip-flop 200_i+1 is turned on can come up earlier, a timing when the potential of the node A is raised can come up earlier.", "Therefore, driving frequency can be increased.", "Alternatively, since the channel width of the transistor 131 or the transistor 132 can be reduced, reduction in a layout area can be achieved.", "Note that in FIG.", "24, the wiring 126 of the flip-flop 200_i+1 can be connected to the wiring 121 of any one of the flip-flops 200_i+M+2 to 200_i+2M.", "In this manner, a timing when the transistor 101 in the flip-flop 200_i+1 is turned off can come up later, falling time of the signal S1_i+1 can be shortened.", "Note that in FIG.", "24, the wiring 126 of the flip-flop 200_i+1 can be connected to the wiring 121 of any one of the flip-flops 200_i+2 to 200_i+M.", "In this manner, the pulse width of the signals S1_1 to S1_N can be made smaller than that of half a cycle of the clock signal.", "Therefore, driving frequency can be increased while reduction in power consumption is achieved.", "Note that in FIG.", "24, it is preferable that M 4.It is more preferable that M<2.This is because, in the case where a shift register in FIGS.", "23A to 23E is used for a scan line driver circuit of a display device, plural kinds of video signals are written to a pixel if M is too large a number.", "Therefore, a period in which an irregular video signal is input to the pixel gets long and display quality is impaired in some cases.", "FIG.", "25B shows an example of a timing chart in the case where M=2.Embodiment 4 In this embodiment, an example of a semiconductor device and a shift register including the semiconductor device will be described.", "Note that the content described in Embodiments 1 to 3 can be applied to that of the semiconductor device and the shift register in this embodiment.", "First, the semiconductor device of this embodiment will be described with reference to FIG.", "19A.", "Note that portions common to those of FIG.", "1A are denoted by common reference numerals, and thus description thereof is omitted.", "The semiconductor device in FIG.", "19A includes the circuit 100, the transistor 101, the transistor 102, the transistor 103, the transistor 104, the capacitor 105, the capacitor 106, and a transistor 301.The transistor 301 corresponds to the transistor 101 and has a similar function to the transistor 101.In addition, the transistor 301 is an n-channel transistor.", "Note that the transistor 301 can be a p-channel transistor.", "A first terminal of the transistor 301 is connected to a wiring 123D.", "A second terminal of the transistor 301 is connected to a wiring 311.A gate of the transistor 301 is connected to the node A.", "The wiring 123D corresponds to the wirings 123A to 123C.", "The signal S2 is input to the wiring 123D.", "Accordingly, as in FIG.", "3D, the wiring 123D and the wirings 123A to 123C can be shared.", "In that case, the first terminal of the transistor 301 is connected to the wiring 123.A signal S7 is output from the wiring 311.The signal S7 corresponds to the signal S1.Next, operation of the semiconductor device in FIG.", "19A is described with reference to a timing chart in FIG.", "19B.", "Note that description of operation in common with the semiconductor device in FIG.", "1A is omitted.", "First, the potential of the node A starts to be raised in the period T1.Then, like the transistor 101, the transistor 301 is turned on when the potential of the node A becomes equal to the sum of the potential (V1) of the wiring 123D and the threshold voltage (Vth301) of the transistor 301, (V1+Vth301).", "Then, the wiring 123D and the wiring 311 are brought into electrical conduction.", "Therefore, since the signal S2 in an L level is supplied from the wiring 123D to the wiring 311, the potential of the wiring 311 is decreased to V1.Next, since the potential of the node A gets (V1+Vth101+α) in the period T2, the transistor 301 is kept on.", "Accordingly, the wiring 123D and the wiring 311 are kept in electrical conduction.", "Therefore, since the signal S2 in an H level is supplied from the wiring 123D to the wiring 311, the potential of the wiring 311 is raised to V2.Next, the potential of the node A starts to decrease to V in the period T3.Like the transistor 101, the transistor 301 is on until the potential of the node A becomes equal to the sum of the potential (V1) of the wiring 123D and the threshold voltage (Vth301) of the transistor 301, (V1+Vth301).", "Therefore, since the signal S1 in an L level is supplied from the wiring 123D to the wiring 311, the potential of the wiring 311 is decreased to V1.After that, when the potential of the node A is decreased to (V1+Vth301), the transistor 301 is turned off.", "During the period T4 and the period T5, since the potential of the node A is maintained as V1, the transistor 301 is kept off.", "Therefore, the wiring 123D and the wiring 311 are kept out of electrical conduction.", "In the semiconductor device in FIG.", "19A, the wiring 121 and the wiring 311 can output signals with the same timings.", "Therefore, one of the signal S1 output from the wiring 121 and the signal S7 output from the wiring 311 can be used for driving a load such as a gate line or a pixel and the other thereof can be used as a signal for driving a different circuit, such as a signal for transferring.", "In this manner, the different circuit can be driven without being adversely influenced by distortion, delay, or the like of a signal caused by driving the load or the like.", "Note that a capacitor can be connected between the gate and the second terminal of the transistor 301.The capacitor corresponds to the capacitor 105.Note that as shown in FIG.", "20A, the transistor 301 can be added to the semiconductor device in FIG.", "6A.", "Note that as shown in FIG.", "20B, a transistor 302, a transistor 303, and/or a transistor 304 can be added.", "The transistor 302, the transistor 303, and the transistor 304 correspond and have similar functions to the transistor 134, the transistor 102, and the transistor 133, respectively.", "A first terminal of the transistor 302 is connected to a wiring 122H.", "A second terminal of the transistor 302 is connected to a wiring 331.A gate of the transistor 302 is connected to the wiring 126.A first terminal of the transistor 303 is connected to the wiring 331.A second terminal of the transistor 303 is connected to the node A.", "A gate of the transistor 303 is connected to a wiring 123E.", "A first terminal of the transistor 304 is connected to a wiring 122I.", "A second terminal of the transistor 304 is connected to the wiring 331.A gate of the transistor 304 is connected to a wiring 124C.", "However, this embodiment is not limited to this.", "Only one or two of the transistor 302, the transistor 303, and the transistor 304 can be added.", "Note that in FIG.", "20B, since the same signal (e.g., the signal S2) as the wirings 123A to 123C is input to the wiring 123D and the wiring 123E, the wiring 123D, the wiring 123E, and the wirings 123A to 123C can be shared.", "In that case, the first terminal of the transistor 301 and the gate of the transistor 303 are connected to the wiring 123.Note that in FIG.", "20B, since the same voltage (e.g., the voltage V1) as the wirings 122A to 122E is input to the wiring 122H and the wiring 122I, the wiring 122H, the wiring 122I, and the wirings 122A to 122E can be shared.", "In that case, the first terminal of the transistor 302 and the gate of the transistor 304 are connected to the wiring 122.Note that in FIG.", "20B, like the transistor 135, the transistor 302 can be replaced with a diode or a diode-connected transistor.", "Alternatively, like the transistor 133, the transistor 304 can be replaced with a diode or a diode-connected transistor.", "Next, one example of a shift register including the above-described semiconductor device is described with reference to FIG.", "21.Note that description of the content described in Embodiment 3 is omitted.", "Alternatively, the same portions as those in FIG.", "14 are denoted by the same reference numerals and description thereof is omitted.", "The shift register includes a plurality of flip-flops of flip-flops 320_1 to 320_N.", "The flip-flops 320_1 to 320_N correspond to the flip-flops 200_1 to 200_N in FIG.", "14.Alternatively, the flip-flops 320_1 to 320_N correspond to the semiconductor device in FIG.", "19A, FIG.", "20A, or FIG.", "20B.", "FIG.", "21 shows one example of the case where the semiconductor device in FIG.", "20A is used.", "In the flip-flop 320_i, the wiring 311 is connected to the wiring 321_i.", "Then, the wiring 126 is connected to the wiring 321_i−1.Signals GS7_1 to GS7_N are output from the wirings 321_1 to 321_N, respectively.", "The signals GS7_1 to GS7_N correspond to the signal S7 and each can function as a transfer signal, an output signal, a selection signal, a scan signal, or a gate signal.", "Next, operation of the shift register shown in FIG.", "21 is described with reference to the timing chart in FIG.", "14B.", "Operation of the flip-flop 320_i is described.", "First, the signal GS7_i−1 goes into an H level.", "Then, the flip-flop 320_i starts operation in the period T2 and the signal GS1_i and the signal GS7_i go into an L level.", "After that, the signal GS2 and the signal GS3 are inverted.", "Then, the flip-flop 320_i starts operation in the period T2 and the signal GS1_i and the signal GS7_i go into an H level.", "The signal GS1_i is input to the flip-flop 320_i−1 as a reset signal and the signal GS7_i is input to the flip-flop 320_i+1 as a start signal.", "Accordingly, the flip-flop 320_i−1 starts operation in the period T3 and the flip-flop 320_i+1 starts operation in the period T1.After that, the signal GS2 and the signal GS3 are inverted again.", "Then, the flip-flop 320_i+1 starts operation in the period T2 and the signal GS1_i+1 goes into an H level.", "The signal GS1_i+1 is input to the flip-flop 320_i as a reset signal.", "Accordingly, since the flip-flop 320_i starts operation in the period T3, the signal GS1_i and the signal GS7_i go into an L level.", "After that, until the signal GS7_i−1 goes into the H level again, the flip-flop 320_i repeats the operation in the period T4 and the operation in the period T5 every time the signal GS2 and the signal GS3 are inverted.", "In the shift register in this embodiment, since the signals GS7_1 to GS7_N are used as start signals, delay time of the signals S1_1 to S1_N can be shortened.", "This is because, since the signals GS7_1 to GS7_N are not input to the gate line, the pixel, or the like, delay or distortion of the signals GS7_1 to GS7_N is slight as compared to the signals S1_1 to S1_N.", "Alternatively, in the shift register of this embodiment, since the signals GS1_1 to GS1_N are used as reset signals, a period of time when the transistor 101 is on in operation of each flip-flop during the period T3 can be made longer.", "Therefore, falling time of the signals S1_1 to S1_N and falling time of the signals GS7_1 to GS7_N can be shortened.", "Note that the signals GS1_1 to GS1_N can be input to the flip-flop in the next stage as start signals.", "For example, the signal GS1_i can be input to the flip-flop 320_i+1 as a start signal.", "Note that the signals GS7_1 to GS7_N can be input to the flip-flop in the previous stage as reset signals.", "For example, the signal GS7_i can be input to the flip-flop 320_i−1 as a reset signal.", "Embodiment 5 In this embodiment, an example of a display device is described.", "First, an example of a system block of a liquid crystal display device is described with reference to FIG.", "22A.", "The liquid crystal display device includes a circuit 5361, a circuit 5362, a circuit 5363_1, a circuit 5363_2, a pixel portion 5364, a circuit 5365, and a lighting device 5366.A plurality of wirings 5371 which is extended from the circuit 5362 and a plurality of wirings 5372 which is extended from the circuit 5363_1 and the circuit 5363_2 are provided in the pixel portion 5364.In addition, pixels 5367 which include display elements such as liquid crystal elements are provided in matrix in respective regions where the plurality of wirings 5371 and the plurality of wirings 5372 intersect with each other.", "The circuit 5361 has a function of outputting a signal, voltage, or the like to the circuit 5362, the circuit 5363_1, the circuit 5363_2, and the circuit 5365 in response to a video signal 5360 and can function as a controller, a control circuit, a timing generator, a regulator, or the like.", "For example, the circuit 5361 outputs a signal such as a signal line driver circuit start signal (SSP), a signal line driver circuit clock signal (SCK), a signal line driver circuit inverted clock signal (SCKB), a video signal data (DATA), or a latch signal (LAT) to the circuit 5362.The circuit 5362 has a function of outputting video signals to the plurality of wirings 5371 in response to such a signal and functions as a signal line driver circuit.", "Note that in the case where the video signals are input to the plurality of wirings 5371, the plurality of wirings 5371 can function as signal lines, video signal lines, source lines, or the like.", "For example, the circuit 5361 outputs a signal such as a scan line driver circuit start signal (GSP), a scan line driver circuit clock signal (GCK), or a scan line driver circuit inverted clock signal (GCKB) to the circuit 5363_1 and the circuit 5363_2.The circuit 5363_1 and the circuit 5363_2 each have a function of outputting scan signals to the plurality of wirings 5372 in response to such a signal and function as a scan line driver circuit.", "Note that in the case where scan signals are input to the plurality of wirings 5372, the plurality of wirings 5372 can function as signal lines, scan lines, gate lines, or the like.", "Note that since the same signal is input to the circuit 5363_1 and the circuit 5363_2 from the circuit 5361, scan signals output from the circuit 5363_1 to the plurality of wirings 5367 and scan signals output from the circuit 5363_2 to the plurality of wirings 5367 have approximately the same timings in many cases.", "Therefore, load caused by driving of the circuit 5363_1 and the circuit 5363_2 can be reduced.", "Accordingly, the display device can be made larger.", "Alternatively, the display device can have higher definition.", "Alternatively, since the channel width of transistors included in the circuit 5363_1 and the circuit 5363_2 can be reduced, a display device with a narrower frame can be obtained.", "For example, the circuit 5361 outputs a backlight control signal (BLC) to the circuit 5365.The circuit 5365 has a function of controlling the luminance (or the average luminance) of the lighting device 5366 by controlling the amount of electric power supplied to the lighting device 5366, time to supply the electric power to the 16 lighting device 5366, or the like in accordance with the backlight control signal (BLC) and functions as a power supply circuit.", "Note that one of the circuit 5363_1 and the circuit 5363_2 can be eliminated.", "Note that a wiring such as a capacitor line, a power supply line, or a scan line can be newly provided in the pixel portion 5364.Then, the circuit 5361 can output a signal, voltage, or the like to such a wiring.", "In addition, a circuit similar to the circuit 5363_1 or the circuit 5363_2 can be additionally provided.", "The additionally provided circuit can output a signal such as a scan signal to the additionally provided wiring.", "Note that the pixel 5367 can include a light-emitting element such as an EL element as a display element.", "In that case, as shown in FIG.", "22B, since the display element emits light, the circuit 5365 and the lighting device 5366 can be eliminated.", "In addition, in order to supply electric power to the display element, a plurality of wirings 5373 which can function as power supply lines can be provided in the pixel portion 5364.The circuit 5361 can supply power supply voltage called voltage (ANO) to the wirings 5373.The wirings 5373 can be separately connected the pixels in accordance with color elements or connected to all the pixels.", "Note that FIG.", "22B shows an example in which the circuit 5361 supplies different signals to the circuit 5363_1 and the circuit 5363_2.The circuit 5361 outputs a signal such as a scan line driver circuit start signal (GSP1), a scan line driver circuit clock signal (GCK1), and a scan line driver circuit inverted clock signal (GCKB1) to the circuit 5363_1.In addition, the circuit 5361 outputs a signal such as a scan line driver circuit start signal (GSP2), a scan line driver circuit clock signal (GCK2), and a scan line driver circuit inverted clock signal (GCKB2) to the circuit 5363_2.In that case, the circuit 5363_1 can scan only wirings in odd-numbered rows of the plurality of wirings 5372 and the circuit 5363_2 can scan only wirings in even-numbered rows of the plurality of wirings 5372.Accordingly, the driving frequency of the circuit 5363_1 and the circuit 53632 can be lowered, whereby reduction in power consumption can be achieved.", "Alternatively, an area in which a flip-flop of one stage can be laid out can be made larger.", "Therefore, a display device can have higher definition.", "Alternatively, a display device can be made larger.", "Note that as in FIG.", "22B, the circuit 5361 can supply different signals to the circuit 5363_1 and the circuit 5363_2 in FIG.", "22A.", "Next, one example of a structure of the display device are described with reference to FIGS.", "23A to 23E.", "In FIG.", "23A, circuits which have a function of outputting signals to the pixel portion 5364 (e.g., the circuit 5362, the circuit 5363_1, and the circuit 5363_2) are formed over a substrate 5380 over which the pixel portion 5364 is also formed.", "In addition, the circuit 5361 is formed over a different substrate from the pixel portion 5364.In this manner, since the number of external components is reduced, reduction in cost can be achieved.", "Alternatively, since the number of signals or voltages input to the substrate 5380 is reduced, the number of connections between the substrate 5380 and the external component can be reduced.", "Therefore, improvement in reliability or increase in yield can be achieved.", "Note that in the case where the circuit is formed over a different substrate from the pixel portion 5364, the substrate can be mounted on an FPC (flexible printed circuit) by a TAB (tape automated bonding) method.", "Alternatively, the substrate can be mounted on the same substrate 5380 as the pixel portion 5364 by a COG (chip on glass) method.", "Note that in the case where the circuit is formed over a different substrate from the pixel portion 5364, a transistor formed using a single crystal semiconductor can be formed on the substrate.", "Therefore, the circuit formed over the substrate can have advantages such as improvement in driving frequency, improvement in driving voltage, or suppression of variations in output signals.", "Note that a signal, voltage, current, or the like is input from an external circuit through an input terminal 5381 in many cases.", "In FIG.", "23B, circuits with low driving frequency (e.g., the circuit 5363_1 and the circuit 5363_2) are formed over the substrate 5380 as the pixel portion 5364.In addition, the circuit 5361 and the circuit 5362 are formed over a different substrate from the pixel portion 5364.In this manner, since the circuit formed over the substrate 5380 can be formed using a transistor with low mobility, a non-single-crystal semiconductor, a microcrystalline semiconductor, an organic semiconductor, an oxide semiconductor, or the like can be used for a semiconductor layer of the transistor.", "Accordingly, increase in the size of the display device, reduction in the number of steps, reduction in cost, improvement in yield, or the like can be achieved.", "Note that as shown in FIG.", "23C, part of the circuit 5362 (a circuit 5362a) can be formed over the substrate 5380 over which the pixel portion 5364 is formed and the other part of the circuit 5362 (a circuit 5362b) can be formed over a different substrate from the pixel portion 5364.The circuit 5362a includes a circuit which can be formed using a transistor with low mobility in many cases (e.g., a shift register, a selector, or a switch).", "In addition, the circuit 5362b includes a circuit which is preferably formed using a transistor with high mobility and few variations in characteristics in many cases (e.g., a shift register, a latch circuit, a buffer circuit, a DA converter circuit, or an AD converter circuit).", "In this manner, as in FIG.", "23B, a non-single-crystal semiconductor, a microcrystalline semiconductor, an organic semiconductor, an oxide semiconductor, or the like can be used for a semiconductor layer of the transistor.", "Further, reduction in external components can be achieved.", "In FIG.", "23D, circuits which have a function of outputting signals to the pixel portion 5364 (e.g., the circuit 5362, the circuit 5363_1, and the circuit 5363_2) and a circuit which has a function of controlling these circuits (e.g., the circuit 5361) are formed over a different substrate from the pixel portion 5364.In this manner, since the pixel portion and peripheral circuits thereof can be formed over different substrates, improvement in yield can be achieved.", "In FIG.", "23E, part of the circuit 5361 (a circuit 5361a) is formed over the substrate 5380 over which the pixel portion 5364 and the other part of the circuit 5361 (a circuit 5361b) is formed over a different substrate from the pixel portion 5364.The circuit 5361a includes a circuit which can be formed using a transistor with low mobility in many cases (e.g., a switch, a selector, or a level shift circuit).", "In addition, the circuit 5361b includes a circuit which is preferably formed using a transistor with high mobility and few variations in many cases (e.g., a shift register, a timing generator, an oscillator, a regulator, or an analog buffer).", "Note that as the circuit 5363_1 and the circuit 5363_2, the semiconductor device or shift register in Embodiments 1 to 4 can be used.", "In that case, if the circuit 5363_1 and the circuit 5363_2 are formed over the same substrate as the pixel portion, the polarity of all transistors formed over the substrate can be n-type or p-type.", "Accordingly, reduction in the number of steps, improvement in yield, or reduction in cost can be achieved.", "In specific, by setting the polarities of all the transistors n-type, a non-single-crystal semiconductor, a microcrystalline semiconductor, an organic semiconductor, an oxide semiconductor, or the like can be used for a semiconductor layer of the transistor.", "Therefore, increase in the size of the display device, reduction in cost, improvement in yield, or the like can be achieved.", "Note that deterioration of characteristics, such as increase in threshold voltage or decrease in mobility, is caused in many cases in the transistor whose semiconductor layer is formed using a non-single-crystal semiconductor, a microcrystalline semiconductor, an organic semiconductor, an oxide semiconductor, or the like.", "However, since deterioration of the characteristics of the transistor can be suppressed in the semiconductor device or shift register in Embodiments 1 to 4, the life of the display device can be made longer.", "Note that the semiconductor device or shift register in Embodiments 1 to 4 can be used as part of the circuit 5362.For example, the circuit 5362a shown in FIG.", "23C can include the semiconductor device or shift register in Embodiments 1 to 4.Embodiment 6 In this embodiment, a layout view (hereinafter also referred to as a top view) of a shift register will be described.", "In this embodiment, for example, a layout view of the shift register shown in FIG.", "15 will be described.", "Note that a content described in this embodiment can be applied to the semiconductor device, the shift register, or the display device in Embodiments 1 to 5 in addition to the shift register in FIG.", "15.Note that the layout view in this embodiment is one example and this embodiment is not limited to this.", "The layout view in this embodiment is described with reference to FIG.", "30 and FIG.", "31.FIG.", "30 illustrates one example of a layout view of part of the shift register.", "FIG.", "31 illustrates a layout view of the flip-flop 200_i, for example.", "A transistor, a capacitor, a wiring, and the like shown in FIG.", "30 and FIG.", "31 each include a conductive layer 401, a semiconductor layer 402, a conductive layer 403, a conductive layer 404, and a contact hole 405.However, this embodiment is not limited to this.", "A different conductive layer, insulating film, or a different contact hole can be newly formed.", "For example, a contact hole which connects the conductive layer 401 to the conductive layer 403 can be additionally provided.", "The conductive layer 401 can include a portion which functions as a gate electrode or a wiring.", "The semiconductor layer 402 can include a portion which 6 functions as a semiconductor layer of the transistor.", "The conductive layer 403 can include a portion which functions as a wiring or a source or drain.", "The conductive layer 404 can include a portion which functions as a transparent electrode, a pixel electrode, or a wiring.", "The contact hole 405 can be used in order to connect the conductive layer 401 and the conductive layer 404 or in order to connect the conductive layer 403 and the conductive layer 404.In the example in FIG.", "30, the wiring 202 includes an opening portion 411 and the wiring 203 includes an opening portion 412.In this manner, since the wiring 202 and the wiring 203 include the opening portions, parasitic capacitance can be reduced.", "Alternatively, breakdown of the transistor due to electrostatic discharge can be suppressed.", "However, this embodiment is not limited to this.", "Like the wiring 204, the opening portion 411 or the opening portion 412 can be eliminated.", "Alternatively, like the wiring 202 or the wiring 203, an opening portion can be provided for the wiring 204.In the example in FIG.", "30, by providing an opening portion in part of an intersection portion of the wiring 202 or the wiring 203 and a different wiring, the cross-over capacitance of the wiring can be reduced.", "Accordingly, reduction in noise or reduction in delay or distortion of a signal can be achieved.", "In the example in FIG.", "30, the conductive layer 404 is formed over part of the conductive layer 403 included in the wiring 204.Then, the conductive layer 404 is connected to the conductive layer 403 through the contact hole 405.In this manner, since wiring resistance can be made low, suppression of voltage drop or reduction in delay or distortion of a signal can be achieved.", "However, this embodiment is not limited to this.", "The conductive layer 404 and the contact hole 405 can be eliminated.", "Alternatively, like the wiring 204, the conductive layer 404 can be formed over part of the conductive layer 403 in the wiring 202 or the wiring 203 so that the conductive layer 404 can be connected to the conductive layer 403.Here, in the example in FIG.", "30, the width of the wiring 202, the width of the wiring 203, and the width of the wiring 204 are denoted as wiring width 421, wiring width 422, and width 423, respectively.", "Then, the width of the opening portion 411, the length of the opening portion 411, the width of the opening portion 412, and the length of the opening portion 412 are denoted as width 424, length 425, width 426, and length 427, respectively.", "Note that signals input to the wiring 202 and the wiring 203 are inverted signals of each other in many cases.", "Therefore, the wiring resistance or the parasitic capacitance of the wiring 202 is preferably set so as to be approximately equal to that of the wiring 203.Accordingly, the wiring 202 preferably includes a portion whose width is approximately equal to the wiring width 422.Alternatively, the opening portion 411 preferably includes a portion whose width is approximately equal to the width 426 of the opening portion 412 or a portion whose length is approximately equal to the length 427 of the opening portion 412.However, this embodiment is not limited to this.", "The wiring width 421, the wiring width 422, the width 424 of the opening portion 411, the length 425 of the opening portion 411, or the length 427 of the opening portion 412 can have a variety of values.", "For example, when the cross-over capacitance of the wiring 202 and a different wiring is higher than that of the wiring 203 and a different wiring, delay or distortion of signals input to the wiring 202 and the wiring 203 can be made approximately the same by decreasing the wiring resistance of the wiring 202.Therefore, the wiring 202 can include a portion which is wider than the wiring width 422.Alternatively, the opening portion 411 can include a portion which is narrower than the width 426 of the opening portion 412.Alternatively, the opening portion 411 can include a portion which is shorter than the length 427 of the opening portion 412.On the other hand, when the cross-over capacitance of the wiring 202 and a different wiring is lower than that of the wiring 203 and a different wiring, the wiring 202 can include a portion whish is narrower than the wiring width 422.Alternatively, the opening portion 411 can include a portion which is wider than the width 426 of the opening portion 412.Alternatively, the opening portion 411 can include a portion which is longer than the length 427 of the opening portion 412.In the case where the wiring 204 does not include the opening portion, the wiring 204 preferably includes a portion which is narrower than the wiring width 421 or the wiring width 422.This is because the wiring 204 does not include an opening portion, and the wiring resistance of the wiring 204 is low.", "However, this embodiment is not limited to this.", "The wiring 204 can include a portion which is wider than the wiring width 421 or the wiring width 422.In the example in FIG.", "31, one electrode of each of the capacitor 105 and the capacitor 106 is formed using the conductive layer 401 and the other electrode of each of the capacitor 105 and the capacitor 106 is formed using a conductive layer 403.Accordingly, since a capacitance value per unit area can be large, reduction in a layout area can be achieved.", "However, this embodiment is not limited to this.", "The semiconductor layer 402 can be provided between the conductive layer 401 and the conductive layer 403.In this manner, short circuit between the conductive layer 401 and the conductive layer 403 can be suppressed.", "Alternatively, the capacitor 105 or the capacitor 106 may be a MOS capacitor.", "In the example in FIG.", "31, in the transistor 101, the transistor 103, the transistor 104, the transistor 131, the transistor 132, the transistor 133, the transistor 134, and the transistor 135, an area where the conductive layers 401 and the conductive layers 403 of the second terminals overlap with each other is preferably smaller than an area where the conductive layers 401 and the conductive layers 403 of the first terminals overlap with each other.", "In this manner, reduction in noise of the gate of the transistor 101 or the wiring 201_i can be achieved.", "Alternatively, since concentration of an electric field on the second terminal can be suppressed, deterioration of the transistor or breakdown of the transistor can be suppressed.", "Note that the semiconductor layer 402 can be provided for a portion in which the conductive layer 401 and the conductive layer 403 overlap with each other.", "Accordingly, the parasitic capacitance between the conductive layer 401 and the conductive layer 403 can be reduced, whereby reduction in noise can be achieved.", "Because of a similar reason, the semiconductor layer 402 or the conductive layer 403 can be provided for a portion in which the conductive layer 401 and the conductive layer 404 overlap with each other.", "Note that the conductive layer 404 can be formed over part of the conductive layer 401 and can be connected to the conductive layer 401 through the contact hole 405.Accordingly, wiring resistance can be reduced.", "Alternatively, the conductive layer 403 and the conductive layer 404 can be formed over part of the conductive layer 401, so that the conductive layer 401 is connected to the conductive layer 404 through the contact hole 405 and the conductive layer 403 can be connected to the conductive layer 404 through the different contact hole 405.In this manner, the wiring resistance can be further reduced.", "Note that the conductive layer 404 can be formed over part of the conductive layer 403, so that the conductive layer 403 can be connected to the conductive layer 404 through the contact hole 405.In this manner, wiring resistance can be reduced.", "Note that the conductive layer 401 or the conductive layer 403 can be formed under part of the conductive layer 404, so that the conductive layer 404 can be connected to the conductive layer 401 or the conductive layer 403 through the contact hole 405.In this manner, wiring resistance can be reduced.", "Note that in the case where the capacitor 105 is eliminated, as described in Embodiment 1, the parasitic capacitance between the gate and the second terminal of the transistor 101 can be higher than the parasitic capacitance between the gate and the first terminal of the transistor 101.One example of a layout view of the transistor 101 in that case is shown in FIG.", "18.In the example in FIG.", "18, the width of the conductive layer 403 which can function as a first electrode of the transistor 101 is referred to as width 431 and the width of the conductive layer 403 which can function as a second electrode of the transistor 101 is referred to as width 432.In addition, the width 431 can be larger than the width 432.In this manner, as described in Embodiment 1, the parasitic capacitance between the gate and the second terminal of the transistor 101 can be higher than the parasitic capacitance between the gate and the first terminal of the transistor 101.However, this embodiment is not limited to this.", "Embodiment 7 In this embodiment, one example of a signal line driver circuit will be described.", "Note that the signal line driver circuit can be referred to as a semiconductor device or a signal generation circuit.", "One example of the signal line driver circuit is described with reference to FIG.", "26A.", "The signal line driver circuit includes a plurality of circuits of circuits 502_1 to 502_N (N is a natural number), a circuit 500, and a circuit 501.In addition, the circuits 502_1 to 502_N each include a plurality of transistors of transistors 503_1 to 503_k (k is a natural number).", "The transistors 503_1 to 503_k are n-channel transistors.", "However, this embodiment is not limited to this.", "The transistors 503_1 to 503_k can be p-channel transistors or CMOS switches.", "A connection relation of the signal line driver circuit will be described by using the circuit 502_1 as an example.", "First terminals of the transistors 503_1 to 503k are connected to the wiring 505_1.Second terminals of the transistors 503_1 to 503_k are connected to wirings S1 to Sk, respectively.", "Gates of the transistors 503_1 to 503_k are connected to wirings 504_1 to 504_k, respectively.", "For example, the first terminal of the transistor 503_1 is connected to the wiring 505_1, the second terminal of the transistor 503_1 is connected to the wiring S1, and the gate of the transistor 503_1 is connected to the wiring 504_1.The circuit 500 has a function of supplying a signal to the circuits 502_1 to 502_N through the wirings 504_1 to 504k and can function as a shift register or a decoder or the like.", "The signal is a digital signal in many cases and can function as a selection signal.", "In addition, the wirings 504_1 to 504_k can function as signal lines.", "The circuit 501 has a function of outputting a signal to the circuits 502_1 to 502_N and can function as a video signal generation circuit or the like.", "For example, the circuit 501 supplies the signal to the circuit 502_1 through the wiring 505_1.At the same time, the circuit 501 supplies the signal to the circuit 502_2 through the wiring 505_2.The signal is an analog signal in many cases and can function as a video signal.", "In addition, the wirings 505_1 to 505_N can function as signal lines.", "The circuits 502_1 to 502k each have a function of selecting a wiring to which an output signal from the circuit 501 is output and can function as a selector circuit.", "For example, the circuit 502_1 has a function of selecting one of the wirings S1 to Sk to output a signal output from the circuit 501 to the wiring 505_1.The transistors 503_1 to 503_k have a function of controlling electric conduction state between the wiring 505_1 and the wirings S1 to Sk in accordance with the output signal from the circuit 500 and function as switches.", "Next, operation of the signal line driver circuit shown in FIG.", "26A is described with reference to a timing chart in FIG.", "26B.", "FIG.", "26B shows examples of a signal 514_1 input to the wiring 504_1, a signal 514_2 input to the wiring 504_2, a signal 514_k input to the wiring 504_k, a signal 515_1 input to the wiring 505_1, and a signal 515_2 input to the wiring 505_2.Note that one operation period of the signal line driver circuit corresponds to one gate selection period in a display device.", "One gate selection period is a period in which a pixel which belongs to one row is selected and a video signal can be written to the pixel.", "Note that one gate selection period is divided into a period T0 and a period T1 to a period Tk.", "The period T0 is a period for applying voltage for precharge on pixels which belong to a selected row at the same time and can be used as a precharge period.", "Each of the periods T1 to Tk is a period in which a video signal is written to pixels which belong to the selected row and can be used as a writing period.", "Note that for simplicity, operation of the signal line driver circuit is described by using operation of the circuit 502_1 as an example.", "First, during the period T0, the circuit 500 outputs a signal in an H level to the wirings 504_1 to 504_k.", "Then, the transistors 503_1 to 503_k are turned on, whereby the wiring 505_1 and the wirings S1 to SAk are brought into electrical conduction.", "At that time, the circuit 501 supplies precharge voltage Vp to the wiring 505_1, so that the precharge voltage Vp is output to the wirings S1 to Sk through the transistors 503_1 to 503_k, respectively.", "Then, the precharge voltage Vp is written to the pixels which belong to the selected row, whereby the pixels which belong to the selected row are precharged.", "Next, during the period T1, the circuit 500 outputs a signal in an H level to the wirings 504_1.Then, the transistor 503_1 is turned on, whereby the wiring 505_1 and the wiring S1 are brought into electrical conduction.", "Then, the wiring 505_1 and the wirings S2 to Sk are brought out of electrical conduction.", "At that time, the circuit 501 supplies a signal Data (S1) to the wiring 505_1, so that the signal Data (S1) is output to the wiring S1 through the transistors 503_1.In this manner, the signal Data (S1) is written to, of the pixels connected to the wiring S1, the pixels which belong to the selected row.", "Next, during the period T2, the circuit 500 outputs a signal in an H level to the wirings 504_2.Then, the transistor 503_2 is turned on, whereby the wiring 505_2 and the wiring S2 are brought into electrical conduction.", "Then, the wiring 505_1 and the wirings S1 are brought out of electrical conduction while the wiring 505_1 and the wirings S3 to Sk are kept out of electrical conduction.", "At that time, when the circuit 501 outputs a signal Data (S2) to the wiring 505_1, the signal Data (S2) is output to the wiring S2 through the transistors 503_2.In this manner, the signal Data (S2) is written to, of the pixels connected to the wiring S2, the pixels which belong to the selected row.", "After that, since the circuit 500 sequentially outputs signals in an H level to the wirings 504_1 to 504k until the end of the period Tk, the circuit 500 sequentially outputs the signal in the H level to the wirings 504_3 to 504_k from the period T3 to the period Tk, as in the period T1 and the period T2.Therefore, since the transistors 503_3 to 503_k are sequentially turned on, the transistors 503_1 to 503_k are 6 sequentially turned on.", "Accordingly, a signal output from the circuit 501 is sequentially output to the wirings S1 to Sk.", "In this manner, the signal can be written to the pixels which belong to the selected row.", "Since the signal line driver circuit in this embodiment includes the circuit which functions as a selector, the number of signals or wirings can be reduced.", "Alternatively, since voltage for precharging is written to the pixel before a video signal is written to the pixel (during period T0), a writing time of the video signal can be shortened.", "Accordingly, increase in the size of a display device and higher resolution of the display device can be achieved.", "However, this embodiment is not limited to this.", "It is possible that the period T0 is eliminated, so that the pixel is not precharged.", "Note that if k is too large a number, a writing time of the pixel is shortened, whereby writing of a video signal to the pixel is not completed in the writing time in some cases.", "Accordingly, it is preferable that k s 6.It is more preferable that k s 3.It is further preferable that k=2.In specific, in the case where a color element of a pixel is divided into n (n is a natural number), it is possible that k=n.", "For example, in the case where a color element of a pixel is divided into red (R), green (G), and blue (B), it is possible that k=3.In that case, one gate selection period is divided into a period T0, a period T1, a period T2, and a period T3.Then, a video signal can be written to the pixel of red (R), the pixel of green (G), and the pixel of blue (B) during the period T1, the period T2, and the period T3, respectively.", "However, this embodiment is not limited to this.", "The order of the period T1, the period T2, and the period T3 can be appropriately set.", "In specific, in the case where a pixel is divided into n (n is a natural number) sub-pixels, it is possible that k=n.", "For example, in the case where the pixel is divided into two sub-pixels, it is possible that k=2.In that case, one gate selection period is divided into the period T0, the period T1, and the period T2.Then, a video signal can be written to one of the two sub-pixels during the period T1, and a video signal can be written to the other of the two sub-pixels during the period T2.Note that since the driving frequencies of the circuit 500 and the circuits 502_1 to 502_N are low in many cases, the circuit 500 and the circuits 502_1 to 502_N can be formed over the same substrate as a pixel portion.", "In this manner, since the number of connections between the substrate over which the pixel portion is formed and an external circuit can be reduced, increase in yield, improvement in reliability, or the like can be achieved.", "Further, as shown in FIG.", "23C, by also forming a scan line driver circuit over the same substrate as the pixel portion, the number of connections between the substrate over which the pixel portion is formed and the external circuit can be further reduced.", "Note that the semiconductor device or shift register described in Embodiments 1 to 4 can be used as the circuit 500.In that case, the polarity of all transistors in the circuit 500 can be n-channel or the polarity of all the transistors in the circuit 500 can be p-channel.", "Accordingly, reduction in the number of steps, increase in yield, or reduction in cost can be achieved.", "Note that the polarity of not only all the transistors included in the circuit 500 but also all transistors in the circuits 502_1 to 502_N can be n-channel or all the transistors in the circuits 502_1 to 502_N p-channel.", "Therefore, in the case where the circuit 500 and the circuits 502_1 to 502_N are formed over the same substrate as the pixel portion, reduction in the number of steps, increase in yield, or reduction in cost can be achieved.", "In specific, by setting the polarity of all transistors to be n-channel, non-single-crystal semiconductors, microcrystalline semiconductors, organic semiconductors, or oxide semiconductors can be used as semiconductor layers of the transistors.", "This is because the driving frequencies of the circuit 500 and the circuits 502_1 to 502_N are low in many cases.", "Embodiment 8 In this embodiment, structures and operations of a pixel which can be applied to a liquid crystal display device are described.", "FIG.", "27A illustrates an example of a pixel structure which can be applied to the liquid crystal display device.", "A pixel 5080 includes a transistor 5081, a liquid crystal element 5082, and a capacitor 5083.A gate of the transistor 5081 is electrically connected to a wiring 5085.A first terminal of the transistor 5081 is electrically connected to a wiring 5084.A second terminal of the transistor 5081 is electrically connected to a first terminal of the liquid crystal element 5082.A second terminal of the liquid crystal element 5082 is electrically connected to a wiring 5087.A first terminal of the capacitor 5083 is electrically connected to the first terminal of the liquid crystal element 5082.A second terminal of the capacitor 5083 is electrically connected to a wiring 5086.The wiring 5084 can function as a signal line.", "The signal line is a wiring for transmitting a signal voltage, which is input from the outside of the pixel, to the pixel 5080.The wiring 5085 can function as a scan line.", "The scan line is a wiring for controlling on and off of the transistor 5081.The wiring 5086 can function as a capacitor line.", "The capacitor line is a wiring for applying a predetermined voltage to the second terminal of the capacitor 5083.The transistor 5081 can function as a switch.", "The capacitor 5083 can function as a storage capacitor.", "The storage capacitor is a capacitor with which the signal voltage continues to be applied to the liquid crystal element 5082 even when the switch is off.", "The wiring 5087 can function as a counter electrode.", "The counter electrode is a wiring for applying a predetermined voltage to the second terminal of the liquid crystal element 5082.Note that a function of each wiring is not limited thereto, and each wiring can have a variety of functions.", "For example, by changing a voltage applied to the capacitor line, a voltage applied to the liquid crystal element can be adjusted.", "Note that the transistor 5081 can be a p-channel transistor or an n-channel transistor because it merely functions as a switch.", "FIG.", "27B illustrates an example of a pixel structure which can be applied to the liquid crystal display device.", "The example of the pixel structure illustrated in FIG.", "27B is the same as that in FIG.", "27A except that the wiring 5087 is eliminated and the second terminal of the liquid crystal element 5082 and the second terminal of the capacitor 5083 are electrically connected to each other.", "The example of the pixel structure in FIG.", "27B can be particularly applied to the case of using a horizontal electric field mode (including an IPS mode and FFS mode) liquid crystal element.", "This is because in the horizontal electric field mode liquid crystal element, the second terminal of the liquid crystal element 5082 and the second terminal of the capacitor 5083 can be formed over one substrate, and thus it is easy to electrically connect the second terminal of the liquid crystal element 5082 and the second terminal of the capacitor 5083.With the pixel structure in FIG.", "10B, the wiring 5087 can be eliminated, whereby a manufacturing process can be simplified, and manufacturing costs can be reduced.", "A plurality of pixel structures illustrated in FIG.", "27A or FIG.", "27B can be arranged in matrix.", "Accordingly, a display portion of a liquid crystal display device is formed, and a variety of images can be displayed.", "FIG.", "27C illustrates a circuit configuration in the case where a plurality of pixel structures illustrated in FIG.", "27A are arranged in matrix.", "FIG.", "27C is the circuit diagram illustrating four pixels among a plurality of pixels included in the display portion.", "A pixel arranged in ith row and jth column (each of i and j is a natural number) is represented as a pixel 5080_i, j, and a wiring 5084_i, a wiring 5085_j, and a wiring 5086_j are electrically connected to the pixel 5080_i, j.", "Similarly, a wiring 5084_i+1, the wiring 5085_j, and the wiring 5086_j are electrically connected to a pixel 5080_i+1,j.", "Similarly, the wiring 5084_i, a wiring 5085_j+1, and a wiring 5086_j+1 are electrically connected to a pixel 5080_i, j+1.Similarly, the wiring 5084_i+1, the wiring 5085_j+1, and the wiring 5086_j+1 are electrically connected to a pixel 5080_i+1,j+1.Note that each wiring can be used in common with a plurality of pixels in the same row or the same column.", "In the pixel structure illustrated in FIG.", "27C, the wiring 5087 is a counter electrode, which is used by all the pixels in common; therefore, the wiring 5087 is not indicated by the natural number i or j.", "Further, since the pixel structure in FIG.", "27B can also be used in this embodiment, the wiring 5087 is not essential even in a structure where the wiring 5087 is described, and can be eliminated when another wiring functions as the wiring 5087, for example.", "The pixel structure in FIG.", "27C can be driven by a variety of driving methods.", "In particular, when the pixels are driven by a method called alternating-current driving, degradation (burn-in) of the liquid crystal element can be suppressed.", "FIG.", "27D is a timing chart of voltages applied to each wiring in the pixel structure in FIG.", "27C in the case where dot inversion driving which is a kind of alternating-current driving is performed.", "By the dot inversion driving, flickers seen when the alternating-current driving is performed can be suppressed.", "Note that FIG.", "27D shows a signal 5185_j which is input to the wiring 5085_j, a signal 5185_j+1 which is input to the wiring 5085_j+1, a signal 5184_i which is input to the wiring 5084_i, a signal 5184_i+1 which is input to the wiring 5084_i+1, and voltage 5186 which is supplied to the wiring 5086_j and the wiring 5086_j+1.In the pixel structure in FIG.", "27C, a switch in a pixel electrically connected to the wiring 5085_j is brought into a selection state (an on state) in a jth gate selection period in one frame period, and into a non-selection state (an off state) in the other periods.", "Then, a (i+1)th gate selection period is provided after the jth gate selection period.", "By performing sequential scanning in such a manner, all the pixels are sequentially brought into a selection state within one frame period.", "In the timing chart of FIG.", "27D, when a voltage is at high level, the switch in the pixel is brought into a selection state; when a voltage is at low level, the switch is brought into a non-selection state.", "Note that this is the case where the transistors in the pixels are n-channel transistors.", "In the case of using p-channel transistors, the relation between the voltage and the selection state is opposite to that in the case of using n-channel transistors.", "In the timing chart illustrated in FIG.", "27D, in the jth gate selection period in a kth frame (k is a natural number), a positive signal voltage is applied to the wiring 5084_i used as a signal line, and a negative signal voltage is applied to the wiring 5084_i+1.Then, in the (i+1)th gate selection period in the kth frame, a negative signal voltage is applied to the wiring 5084_i, and a positive signal voltage is applied to the wiring 5084_i+1.After that, signals whose polarity is reversed in each gate selection period are alternately supplied to the signal line.", "Thus, in the kth frame, the positive signal voltage is applied to the pixels 5080_i, j and 5080_i+1, j+1, and the negative signal voltage is applied to the pixels 5080_i+1,j and 5080_i,j+1.Then, in a (k+1)th frame, a signal voltage whose polarity is opposite to that of the signal voltage written in the kth frame is written to each pixel.", "Thus, in the (k+1)th frame, the positive signal voltage is applied to the pixels 5080_i+1, j and 5080_i, j+1, and the negative signal voltage is applied to the pixels 5080_i,j and 5080_i+1, j+1.In such a manner, the dot inversion driving is a driving method in which signal voltages whose polarity is different between adjacent pixels are applied in one frame and the polarity of the voltage signal for the pixel is reversed in each frame.", "By the dot inversion driving, flickers seen when the entire or part of an image to be displayed is uniform can be suppressed while degradation of the liquid crystal element is suppressed.", "Note that voltages applied to all the wirings 5086 including the wirings 5086_j and 5086_j+1 can be a fixed voltage.", "Moreover, only the polarity of the signal voltages for the wirings 5084 is shown in the timing chart, the signal voltages can actually have a variety of values in the polarity shown.", "Here, the case where the polarity is reversed per dot (per pixel) is described; however, this embodiment is not limited thereto, and the polarity can be reversed per a plurality of pixels.", "For example, the polarity of signal voltages to be written is reversed per two gate selection periods, whereby power consumed by writing the signal voltages can be reduced.", "Alternatively, the polarity may be reversed per column (source line inversion) or per row (gate line inversion).", "Note that a fixed voltage may be applied to the second terminal of the capacitor 5083 in the pixel 5080 in one frame period.", "Since a voltage applied to the wiring 5085 used as a scan line is at low level in most of one frame period, which means that a substantially constant voltage is applied to the wiring 5085; therefore, the second terminal of the capacitor 5083 in the pixel 5080 may be connected to the wiring 5085.FIG.", "27E illustrates an example of a pixel structure which can be applied to the liquid crystal display device.", "Compared to the pixel structure in FIG.", "27C, a feature of the pixel structure in FIG.", "27E is that the wiring 5086 is eliminated and the second terminal of the capacitor 5083 in the pixel 5080 and the wiring 5085 in the previous row are electrically connected to each other.", "Specifically, in the range illustrated in FIG.", "27E, the second terminals of the capacitors 5083 in the pixels 5080_i, j+1 and 5080_i+1,j+1 are electrically connected to the wiring 5085_j.", "By electrically connecting the second terminal of the capacitor 5083 in the pixel 5080 and the wiring 5085 in the previous row in such a manner, the wiring 5086 can be eliminated, so that the aperture ratio of the pixel can be increased.", "Note that the second terminal of the capacitor 5083 may be connected to the wiring 5085 in another row instead of in the previous row.", "Further, the pixel structure in FIG.", "27E can be driven by a similar driving method to that in the pixel structure in FIG.", "27C.", "Note that a voltage applied to the wiring 5084 used as a signal line can be made lower by using the capacitor 5083 and the wiring electrically connected to the second terminal of the capacitor 5083.A pixel structure and a driving method in that case will be described with reference to FIGS.", "27F and 27G.", "Compared to the pixel structure in FIG.", "27A, a feature of the pixel structure in FIG.", "27F is that two wirings 5086 are provided per pixel row, and in adjacent pixels, one wiring is electrically connected to every other second terminal of the capacitors 5083 and the other wiring is electrically connected to the remaining every other second terminal of the capacitors 5083.Two wirings 5086 are referred to as a wiring 5086-1 and a wiring 5086-2.Specifically, in the range illustrated in FIG.", "27F, the second terminal of the capacitor 5083 in the pixel 5080_i, j is electrically connected to a wiring 5086-1_j; the second terminal of the capacitor 5083 in the pixel 5080_i+1,j is electrically connected to a wiring 5086-2_j; the second terminal of the capacitor 5083 in the pixel 5080_i, j+1 is electrically connected to a wiring 5086-2_j+1; and the second terminal of the capacitor 5083 in the pixel 5080_i+1, j+1 is electrically connected to a wiring 5086-1_j+1.Note that FIG.", "27G shows the signal 5185_j which is input to the wiring 5085_j, the signal 5185_j+1 which is input to the wiring 5085_j+1, the signal 5184_i which is input to the wiring 5084_i, the signal 5184_i+1 which is input to the wiring 5084_i+1, a signal 5186-1_j which is input to the wiring 5086-1_j, a signal 5186-2_j which is input to the wiring 5086-2_j, a signal 5186-1_j+1 which is input to the wiring 5086-1_j+1, and a signal 5186-2_j+1 which is input to the wiring 5086-2_j+1.For example, when a positive signal voltage is written to the pixel 5080_i, j in the kth frame as illustrated in FIG.", "27C; the wiring 5086-1_j becomes low level, and is changed to high level after the jth gate selection period.", "Then, the wiring 5086-1_j is kept at high level in one frame period, and after a negative signal voltage is written in the jth gate selection period in the (k+1)th frame, the wiring 5086-1_j is changed to high level.", "In such a manner, a voltage of the wiring which is electrically connected to the second terminal of the capacitor 5083 is changed to the positive direction after a positive signal voltage is written to the pixel, whereby a voltage applied to the liquid crystal element can be changed to the positive direction by a predetermined amount.", "That is, a signal voltage written to the pixel can be reduced accordingly, so that power consumed by signal writing can be reduced.", "Note that when a negative signal voltage is written in the jth gate selection period, a voltage of the wiring which is electrically connected to the second terminal of the capacitor 5083 is changed to the negative direction after a negative signal voltage is written to the pixel.", "Accordingly, a voltage applied to the liquid crystal element can be changed to the negative direction by a predetermined amount, and the signal voltage written to the pixel can be reduced as in the case of the positive polarity.", "In other words, as for the wiring which is electrically connected to the second terminal of the capacitor 5083, different wirings are preferably used for a pixel to which a positive signal voltage is applied and a pixel to which a negative signal voltage is applied in the same row in one frame.", "FIG.", "27F illustrates the example in which the wiring 5086-1 is electrically connected to the pixel to which a positive signal voltage is applied in the kth frame, and the wiring 5086-2 is electrically connected to the pixel to which a negative signal voltage is applied in the kth frame.", "Note that this is just an example, and for example, in the case of using a driving method in which pixels to which a positive signal voltage is applied and pixels to which a negative signal voltage is applied are arranged every two pixels, the wirings 5086-1 and 5086-2 are preferably electrically connected to every alternate two pixels accordingly.", "Furthermore, in the case where signal voltages of the same polarity are written in all the pixels in one row (gate line inversion), one wiring 5086 may be provided per row.", "In other words, in the pixel structure in FIG.", "27C, the driving method where a signal voltage written to a pixel is reduced as described with reference to FIGS.", "27F and 27G can be used.", "Next, a pixel structure and a driving method which are preferably employed particularly in the case where a liquid crystal element employs a vertical alignment (VA) mode typified by an MVA mode and a PVA mode.", "The VA mode has advantages such as no rubbing step in manufacture, little light leakage at the time of black display, and low driving voltage, but has a problem in that the image quality is degraded (the viewing angle is narrower) when a screen is seen from an oblique angle.", "In order to increase the viewing angle in the VA mode, a pixel structure where one pixel includes a plurality of subpixels as illustrated in FIGS.", "28A and 28B is effective.", "Pixel structures illustrated in FIGS.", "28A and 28B are examples of the case where the pixel 5080 includes two subpixels (a subpixel 5080-1 and a subpixel 5080-2).", "Note that the number of subpixels in one pixel is not limited to two and can be other numbers.", "The viewing angle can be further increased as the number of subpixels is increased.", "A plurality of subpixels can have the same circuit configuration; here, all the subpixels have the circuit configuration illustrated in FIG.", "27A.", "The first subpixel 5080-1 includes a transistor 5081-1, a liquid crystal element 5082-1, and a capacitor 5083-1.The connection relation is the same as that in the circuit configuration in FIG.", "27A.", "Similarly, the second subpixel 5080-2 includes a transistor 5081-2, a liquid crystal element 5082-2, and a capacitor 5083-2.The connection relation is the same as that in the circuit configuration in FIG.", "27A.", "The pixel structure in FIG.", "28A includes, for two subpixels forming one pixel, two wirings 5085 (a wiring 5085-1 and a wiring 5085-2) used as scan lines, one wiring 5084 used as a signal line, and one wiring 5086 used as a capacitor line.", "When the signal line and the capacitor line are shared with two subpixels in such a manner, the aperture ratio can be increased.", "Further, since a signal line driver circuit can be simplified, manufacturing costs can be reduced.", "Moreover, since the number of connections between a liquid crystal panel and a driver circuit IC can be reduced, the yield can be increased.", "The pixel structure in FIG.", "28B includes, for two subpixels forming one pixel, one wiring 5085 used as a scan line, two wirings 5084 (a wiring 5084-1 and a wiring 5084-2) used as signal lines, and one wiring 5086 used as a capacitor line.", "When the scan line and the capacitor line are shared with two subpixels in such a manner, the aperture ratio can be increased.", "Further, since the total number of scan lines can be reduced, one gate line selection period can be sufficiently long even in a high-definition liquid crystal panel, and an appropriate signal voltage can be written in each pixel.", "FIGS.", "28C and 28D illustrate an example in which the liquid crystal element in the pixel structure in FIG.", "28B is replaced with the shape of a pixel electrode and electrical connections of each element are schematically shown.", "In FIGS.", "28C and 28D, an electrode 5088-1 represents a first pixel electrode, and an electrode 5088-2 represents a second pixel electrode.", "In FIG.", "28C, the first pixel electrode 5088-1 corresponds to a first terminal of the liquid crystal element 5082-1 in FIG.", "28B, and the second pixel electrode 5088-2 corresponds to a first terminal of the liquid crystal element 5082-2 in FIG.", "28B.", "That is, the first pixel electrode 5088-1 is electrically connected to one of a source and a drain of the transistor 5081-1, and the second pixel electrode 5088-2 is electrically connected to one of a source and a drain of the transistor 5081-2.In FIG.", "28D, the connection relation between the pixel electrode and the transistor is opposite to that in FIG.", "28C.", "That is, the first pixel electrode 5088-1 is electrically connected to one of the source and the drain of the transistor 5081-2, and the second pixel electrode 5088-2 is electrically connected to one of the source and the drain of the transistor 5081-1.By arranging a plurality of pixel structures as illustrated in FIG.", "28C or FIG.", "28D in matrix, an extraordinary effect can be obtained.", "FIGS.", "28E and 28F illustrate an example of such a pixel structure and driving method.", "In the pixel structure in FIG.", "28E, a portion corresponding to the pixels 5080_i, j and 5080_i+1,j+1 has the structure illustrated in FIG.", "28C, and a portion corresponding to the pixels 5080_i+1,j and 5080_i, j+1 has the structure illustrated in FIG.", "28D.", "When this structure is driven as shown in the timing chart of FIG.", "28F, a positive signal voltage is written to the first pixel electrode in the pixel 5080_i,j and the second pixel electrode in the pixel 5080_i+1,j, and a negative signal voltage is written to the second pixel electrode in the pixel 5080_i, j and the first pixel electrode in the pixel 5080_i+1, j.", "Then, in the (i+1)th gate selection period in the kth frame, a positive signal voltage is written to the second pixel electrode in the pixel 5080_i,j+1 and the first pixel electrode in the pixel 5080_i+1, j+1, and a negative signal voltage is written to the first pixel electrode in the pixel 5080_i, j+1 and the second pixel electrode in the pixel 5080_i+1,j+1.In the (k+1)th frame, the polarity of the signal voltage is reversed in each pixel.", "Accordingly, the polarity of the voltage applied to the signal line can be the same in one frame period while driving corresponding to dot inversion driving is realized in the pixel structure including subpixels, whereby power consumed by writing the signal voltages to the pixels can be drastically reduced.", "Note that voltages applied to all the wirings 5086 including the wirings 5086_j and 5086_j+1 can be a fixed voltage.", "Note that FIG.", "27F shows the signal 5185_j which is input to the wiring 5085_j, the signal 5185_j+1 which is input to the wiring 5085_j+1, the signal 5184-1_i which is input to the wiring 5084-1_i, the signal 5184-2_i which is input to the wiring 5084-2_i, a signal 5184-1_i+1 which is input to the wiring 5084-1_i+1, a signal 5184-2_i+1 which is input to the wiring 5084-2_i+1, and the voltage 5186 which is supplied to the wiring 5086_j and the wiring 5086_j+1.Further, by a pixel structure and a driving method illustrated in FIGS.", "28G and 28H, the level of the signal voltage written to a pixel can be reduced.", "In the structure, a plurality of subpixels included in each pixel are electrically connected to respective capacitor lines.", "That is, according to the pixel structure and the driving method illustrated in FIGS.", "28G and 28H, one capacitor line is shared with subpixels in one row, to which signal voltages of the same polarity are written in one frame; and subpixels to which signal voltages of the different polarities are written in one frame use different capacitor lines in one row.", "Then, when writing in each row is finished, voltages of the capacitor lines are changed to the positive direction in the subpixels to which a positive signal voltage is written, and changed to the negative direction in the subpixels to which a negative signal voltage is written; thus, the level of the signal voltage written to the pixel can be reduced.", "Specifically, two wirings 5086 (the wirings 5086-1 and 5086-2) used as capacitor lines are provided per row.", "The first pixel electrode in the pixel 5080_i, j and the wiring 5086-1_j are electrically connected through the capacitor.", "The second pixel electrode in the pixel 5080_i, j and the wiring 5086-2_j are electrically connected through the capacitor.", "The first pixel electrode in the pixel 5080_i+1, j and the wiring 5086-2_j are electrically connected through the capacitor.", "The second pixel electrode in the pixel 5080_i+1, j and the wiring 5086-1_j are electrically connected through the capacitor.", "The first pixel electrode in the pixel 5080_i, j+1 and the wiring 5086-2_j+1 are electrically connected through the capacitor.", "The second pixel electrode in the pixel 5080_i, j+1 and the wiring 5086-1_j+1 are electrically connected through the capacitor.", "The first pixel electrode in the pixel 5080_i+1, j+1 and the wiring 5086-1_j+1 are electrically connected through the capacitor.", "The second pixel electrode in the pixel 5080_i+1, j+1 and the wiring 5086-2_j+1 are electrically connected through the capacitor.", "Note that this is just an example, and for example, in the case of using a driving method in which pixels to which a positive signal voltage is applied and pixels to which a negative signal voltage is applied are arranged every two pixels, the wirings 5086-1 and 5086-2 are preferably electrically connected to every alternate two pixels accordingly.", "Furthermore, in the case where signal voltages of the same polarity are written in all the pixels in one row (gate line inversion), one wiring 5086 may be provided per row.", "In other words, in the pixel structure in FIG.", "28E, the driving method where a signal voltage written to a pixel is reduced as described with reference to FIGS.", "28G and 28H can be used.", "Note that FIG.", "28H shows the signal 5185_j which is input to the wiring 5085_j, the signal 5185_j+1 which is input to the wiring 5085_j+1, the signal 5184-1_i which is input to the wiring 5084-1_, the signal 5184-2_i which is input to the wiring 5084-2_i, the signal 5184-1_i+1 which is input to the wiring 5084-1_i+1, the signal 5184-2_i+1 which is input to the wiring 5084-2_i+1, the signal 5186-1_j which is input to the wiring 5086-1_j, the signal 5186-2_j which is input to the wiring 5086-2_j, the signal 5186-1_j+1 which is input to the wiring 5086-1_j+1, and the signal 5186-2_j+1 which is input to the wiring 5086-2_j+1.By a combination of the pixel in this embodiment and the semiconductor device, shift register, or display device in Embodiments 1 to 7, a variety of advantages can be obtained.", "For example, in the case where the pixel with a sub-pixel structure is used, since the number of signals required for driving the display device is increased, the number of gate lines or source lines is increased in some cases.", "As a result, the number of connections between a substrate over which a pixel portion is formed and an external circuit is largely increased in some cases.", "However, even if the number of gate lines is increased, a scan line driver circuit can be formed over the same substrate as the pixel portion as shown in Embodiment 5.Accordingly, the pixel with the sub-pixel structure can be used without largely increasing the number of connections between the substrate over which the pixel portion is formed and the external circuit.", "Alternatively, even if the number of source lines is increased, the number of source lines can be decreased by using the signal line driver circuit in Embodiment 7.Therefore, the pixel with the sub-pixel structure can be used without largely increasing the number of connections between the substrate over which the pixel portion is formed and the external circuit.", "Alternatively, in the case where a signal is input to a capacitor line, the number of connections between the substrate over which the pixel portion is formed and the external circuit is largely increased in some cases.", "Accordingly, the signal can be supplied to the capacitor line by using the semiconductor device or shift register in Embodiments 1 to 4.In addition, the semiconductor device or shift register in Embodiments 1 to 4 can be formed over the same substrate as the pixel portion.", "Therefore, the signal can be input to the capacitor line without largely increasing the number of connections between the substrate over which the pixel portion is formed and the external circuit.", "Alternatively, in the case where alternate-current driving is employed, a writing time of a video signal to the pixel becomes long.", "As a result, enough writing time of the video signal to the pixel cannot be obtained in some cases.", "Similarly, in the case where the pixel with the sub-pixel structure is used, the writing time of the video signal to the pixel is shortened.", "As a result, enough writing time of the video signal to the pixel cannot be obtained in some cases.", "By using the signal line driver circuit in Embodiment 7, the video signal can be written to the pixel.", "In that case, since voltage for precharge is written to the pixel before the video signal is written to the pixel, the video signal can be written to the pixel in a short time.", "Alternatively, as shown in FIG.", "24 and FIGS.", "25A and 25B, by overlapping a period in which one row is selected and a period in which a different row is selected with each other, a video signal in a different row can be used as the voltage for precharging.", "Note that by a combination of the driving method of the pixel in this embodiment and the driving method shown in FIG.", "24 and FIGS.", "25A and 25B, the writing time of the video signal to the pixel can be shortened.", "This is described in detail with reference to a timing chart in FIG.", "29A and a pixel structure in FIG.", "27C.", "A positive video signal is input to the wiring 5084_i and a negative video signal is input to the wiring 5084_i+1 in the kth frame.", "In addition, a negative video signal is input to the wiring 5084_i and a positive video signal is input to the wiring 5084_i+1 in the (k+1)th frame.", "In the (k+1)th frame, so-called source line inversion driving is performed.", "Moreover, for example, the latter half of a period in which an H signal is input to the wiring 5085_j and the first half of a period in which an H signal is input to the wiring 5085_j+1 overlap with each other.", "Further, a negative video signal is written to and held in the pixels 5080_i and 5080_j+1 in the (k−1)th frame.", "A positive video signal is written to and held in the pixels 5080_i+1 and 5080_j+1.Note that FIG.", "29A shows the signal 5185_j which is input to the wiring 5085_j, the signal 5185_j+1 which is input to the wiring 5085_j+1, the signal 5184_i which is input to the wiring 5084_i, and the signal 5184_i+1 which is input to the wiring 5084_i+1.First, in the kth frame, a positive video signal is written to the pixels 5080_i and 5080_j and a negative video signal is written to the pixels 5080_i+1 and 5080_j during a period when the period in which the H signal is input to the wiring 5085_j and the period in which the H signal is input to the wiring 5085_j+1 overlap with each other.", "At that time, the positive video signal is also written to the pixels 5080_i and 5080_j+1 and the negative video signal is also written to the pixels 5080_i+1 and 5080_j+1.In this manner, pixels in a (j+1)th row are precharged by using the video signal written to pixels in a jth row.", "After that, in the kth frame, a positive video signal is written to the pixels 5080_i and 5080_j+1 and a negative video signal is written to the pixels 5080_i+ and 5080_j+1 during the latter half of the period in which the H signal is input to the wiring 5080_j+1.It is needless to say that the positive video signal is written to the pixel 5080_i and a pixel 5080_j+2, whereby the pixels 5080_i and 5080_j+2 are precharged.", "Similarly, the negative video signal is written to the pixels 5080_i+1 and 5080_j+2, whereby the pixels 5080_i+1 and 5080_j+2 are precharged.", "In this manner, by precharging the pixels in the (j+1)th row by using the video signal written to the pixels in the jth row, a writing time of the video signal to the pixels in the (j+1)th row can be shortened.", "Note that by a combination of the driving method in FIG.", "29A and the pixel structure in FIG.", "29B, dot inversion driving can be realized.", "In the pixel structure in FIG.", "29B, the pixels 5080_i and 5080_j are connected to the wiring 5084_i.", "On the other hand, the pixels 5080_i and 5080_j+1 are connected to the wiring 5084_i+1.That is, each of pixels in an ith column is alternately connected to the wiring 5084_i or the wiring 5084_i+1 with respect to one row.", "In this manner, since a positive video signal or a negative video signal is alternately written to each of the pixels in the ith column, the dot inversion driving can be realized.", "However, this embodiment is not limited to this.", "Each of the pixels in the ith column can be alternately connected to the wiring 5084_i or the wiring 5084_i+1 with respect to a plurality of rows (e.g., two rows or three rows).", "Embodiment 9 In this embodiment, examples of structures of transistors are described with reference to FIGS.", "32A, 32B, and 32C.", "FIG.", "32A illustrates an example of a structure of a top-gate transistor.", "FIG.", "32B illustrates an example of a structure of a bottom-gate transistor.", "FIG.", "32C illustrates an example of a structure of a transistor formed using a semiconductor substrate.", "FIG.", "32A illustrates a substrate 5260; an insulating layer 5261 formed over the substrate 5260; a semiconductor layer 5262 which is formed over the insulating layer 5261 and is provided with a region 5262a, a region 5262b, a region 5262c, a region 5262d, and a region 5262e; an insulating layer 5263 formed so as to cover the semiconductor layer 5262; a conductive layer 5264 formed over the semiconductor layer 5262 and the insulating layer 5263; an insulating layer 5265 which is formed over the insulating layer 5263 and the conductive layer 5264 and is provided with openings; a conductive layer 5266 which is formed over the insulating layer 5265 and in the openings formed in the insulating layer 5265; an insulating layer 5267 which is formed over the conductive layer 5266 and the insulating layer 5265 and is provided with an opening; a conductive layer 5268 which is formed over the insulating layer 5267 and in the opening formed in the insulating layer 5267; an insulating layer 5269 which is formed over the insulating layer 5267 and the conductive layer 5268 and is provided with the opening; a light-emitting layer 5270 which is formed over the insulating layer 5269 and in the opening formed in the insulating layer 5269; and a conductive layer 5271 formed over the insulating layer 5269 and the light-emitting layer 5270.FIG.", "32B illustrates a substrate 5300; a conductive layer 5301 formed over the substrate 5300; an insulating layer 5302 formed so as to cover the conductive layer 5301; a semiconductor layer 5303a formed over the conductive layer 5301 and the insulating layer 5302; a semiconductor layer 5303b formed over the semiconductor layer 5303a; a conductive layer 5304 formed over the semiconductor layer 5303b and the insulating layer 5302; an insulating layer 5305 which is formed over the insulating layer 5302 and the conductive layer 5304 and is provided with an opening; a conductive layer 5306 which is formed over the insulating layer 5305 and in the opening formed in the insulating layer 5305; a liquid crystal layer 5307 formed over the insulating layer 5305 and the conductive layer 5306; and a conductive layer 5308 formed over the liquid crystal layer 5307.FIG.", "32C illustrates a semiconductor substrate 5352 including a region 5353 and a region 5355; an insulating layer 5356 formed over the semiconductor substrate 5352; an insulating layer 5354 formed over the semiconductor substrate 5352; a conductive layer 5357 formed over the insulating layer 5356; an insulating layer 5358 which is formed over the insulating layer 5354, the insulating layer 5356, and the conductive layer 5357 and is provided with openings; and a conductive layer 5359 which is formed over the insulating layer 5358 and in the openings formed in the insulating layer 5358.Thus, a transistor is formed in each of a region 5350 and a region 5351.The insulating layer 5261 can function as a base film.", "The insulating layer 5354 functions as an element isolation layer (e.g., a field oxide film).", "Each of the insulating layer 5263, the insulating layer 5302, and the insulating layer 5356 can function as a gate insulating film.", "Each of the conductive layer 5264, the conductive layer 5301, and the conductive layer 5357 can function as a gate electrode.", "Each of the insulating layer 5265, the insulating layer 5267, the insulating layer 5305, and the insulating layer 5358 can function as an interlayer film or a planarization film.", "Each of the conductive layer 5266, the conductive layer 5304, and the conductive layer 5359 can function as a wiring, an electrode of a transistor, an electrode of a capacitor, or the like.", "Each of the conductive layer 5268 and the conductive layer 5306 can function as a pixel electrode, a reflective electrode, or the like.", "The insulating layer 5269 can function as a bank.", "Each of the conductive layer 5271 and the conductive layer 5308 can function as a counter electrode, a common electrode, or the like.", "As each of the substrate 5260 and the substrate 5300, a glass substrate, a quartz substrate, a silicon substrate, a metal substrate, a stainless steel substrate, a flexible substrate, or the like can be used, for example.", "As a glass substrate, a barium borosilicate glass substrate, an aluminoborosilicate glass substrate, or the like can be used, for example.", "For a flexible substrate, a flexible synthetic resin such as plastics typified by polyethylene terephthalate (PET), polyethylene naphthalate (PEN), and polyether sulfone (PES), or acrylic can be used, for example.", "Alternatively, an attachment film (formed using polypropylene, polyester, vinyl, polyvinyl fluoride, polyvinyl chloride, or the like), paper of a fibrous material, a base material film (formed using polyester, polyamide, an inorganic vapor deposition film, paper, or the like), or the like can be used.", "As the semiconductor substrate 5352, for example, a single crystal silicon substrate having n-type or p-type conductivity can be used.", "Note that this embodiment is not limited to this, and a substrate which is similar to the substrate 5260 can be used.", "For example, the region 5353 is a region where an impurity is added to the semiconductor substrate 5352 and functions as a well.", "For example, in the case where the semiconductor substrate 5352 has p-type conductivity, the region 5353 has n-type conductivity and functions as an n-well.", "On the other hand, in the case where the semiconductor substrate 5352 has n-type conductivity, the region 5353 has p-type conductivity and functions as a p-well.", "For example, the region 5355 is a region where an impurity is added to the semiconductor substrate 5352 and functions as a source region or a drain region.", "Note that an LDD region can be formed in the semiconductor substrate 5352.For the insulating layer 5261, a single-layer structure or a layered structure of an insulating film containing oxygen or nitrogen, such as silicon oxide (SiOx), silicon nitride (SiNx), silicon oxynitride (SiOxNy) (x>y), or silicon nitride oxide (SiNxOy) (x>y) can be used, for example.", "In an example in the case where the insulating film 5261 has a two-layer structure, a silicon nitride film and a silicon oxide film can be formed as a first insulating film and a second insulating film, respectively.", "In an example in the case where the insulating film 5261 has a three-layer structure, a silicon oxide film, a silicon nitride film, and a silicon oxide film can be formed as a first insulating film, a second insulating film, and a third insulating film, respectively.", "As an example of each of the semiconductor layer 5262, the semiconductor layer 5303a, and the semiconductor layer 5303b, a single layer structure or layered structure of an amorphous semiconductor, microcrystalline (microcrystal) semiconductor, a polycrystalline semiconductor, a single crystal semiconductor, an oxide semiconductor (e.g., zinc oxide (ZnO) or IGZO (InGaZnO), or compound semiconductor (e.g., gallium arsenide (GaAs)) can be given.", "Note that for example, the region 5262a is an intrinsic region where an impurity is not added to the semiconductor layer 5262 and functions as a channel region.", "However, a slight amount of impurities can be added to the region 5262a.", "The concentration of the impurity added to the region 5262a is preferably lower than the concentration of an impurity added to the region 5262b, the region 5262c, the region 5262d, or the region 5262e.", "Each of the region 5262b and the region 5262d is a region to which an impurity is added at low concentration and functions as an LDD (lightly doped drain) region.", "Note that the region 5262b and the region 5262d can be eliminated.", "Each of the region 5262c and the region 5262e is a region to which an impurity is added at high concentration and functions as a source region or a drain region.", "Note that in the case where the semiconductor layer 5262 is used for a transistor, the conductivity type of the region 5262c and the conductivity type of the region 5262e are preferably the same.", "Note that the semiconductor layer 5303b is a semiconductor layer to which phosphorus or the like is added as an impurity element and has n-type conductivity.", "Note that in the case where an oxide semiconductor or a compound semiconductor is used for the semiconductor layer 5303a, the semiconductor layer 5303b can be eliminated.", "For each of the insulating layer 5263, the insulating layer 5302, and the insulating layer 5356, a single-layer structure or a layered structure of an insulating film containing oxygen or nitrogen, such as silicon oxide (SiOx), silicon nitride (SiNx), silicon oxynitride (SiOxNy) (x>y), or silicon nitride oxide (SiNxOy) (x>y) can be used, for example.", "As each of the conductive layer 5264, the conductive layer 5266, the conductive layer 5268, the conductive layer 5271, the conductive layer 5301, the conductive layer 5304, the conductive layer 5306, the conductive layer 5308, the conductive layer 5357, and the conductive layer 5359, for example, a conductive film having a single-layer structure or a layered structure, or the like can be used.", "For example, for the conductive film, a single-layer film containing one element selected from the group consisting of aluminum (Al), tantalum (Ta), titanium (Ti), molybdenum (Mo), tungsten (W), neodymium (Nd), chromium (Cr), nickel (Ni), platinum (Pt), gold (Au), silver (Ag), copper (Cu), manganese (Mn), cobalt (Co), niobium (Nb), silicon (Si), iron (Fe), palladium (Pd), carbon (C), scandium (Sc), zinc (Zn), phosphorus (P), boron (B), arsenic (As), gallium (Ga), indium (In), tin (Sn), and oxygen (O); a compound containing one or more elements selected from the above group; or the like can be used.", "For example, the compound is an alloy containing one or more elements selected from the above group (e.g., an alloy material such as indium tin oxide (ITO), indium zinc oxide (IZO), indium tin oxide containing silicon oxide (ITSO), zinc oxide (ZnO), tin oxide (SnO), cadmium tin oxide (CTO), aluminum-neodymium (Al—Nd), magnesium-silver (Mg—Ag), molybdenum-niobium (Mo—Nb), molybdenum-tungsten (Mo—W), or molybdenum-tantalum (Mo—Ta)); a compound containing nitrogen and one or more elements selected from the above group (e.g., a nitride film containing titanium nitride, tantalum nitride, molybdenum nitride, or the like); or a compound containing silicon and one or more elements selected from the above group (e.g., a silicide film containing tungsten silicide, titanium silicide, nickel silicide, aluminum silicon, or molybdenum silicon); or the like.", "Alternatively, a nanotube material such as a carbon nanotube, an organic nanotube, an inorganic nanotube, or a metal nanotube can be used.", "Note that silicon (Si) can contain an n-type impurity (e.g., phosphorus) or a p-type impurity (e.g., boron).", "Note that in the case where copper is used for the conductive layer, a layered structure is preferably used in order to improve adhesion.", "Note that for a conductive layer which is in contact with an oxide semiconductor or silicon, molybdenum or titanium is preferably used.", "Note that by using an alloy material containing neodymium and aluminum for the conductive layer, aluminum does not easily cause hillocks.", "Note that in the case where a semiconductor material such as silicon is used for the conductive layer, the semiconductor material such as silicon can be formed at the same time as a semiconductor layer of a transistor.", "Note that since ITO, IZO, ITSO, ZnO, Si, SnO, CTO, a carbon nanotube, or the like has light-transmitting properties, such a material can be used for a portion through which light passes, such as a pixel electrode, a counter electrode, or a common electrode.", "Note that by using a layered structure containing a low-resistance material (e.g., aluminum), wiring resistance can be lowered.", "Note that by using a layered structure where a low heat-resistance material (e.g., aluminum) is interposed between high heat-resistance materials (e.g., molybdenum, titanium, or neodymium), advantages of the low heat-resistance material can be effectively utilized and heat resistance of a wiring, an electrode, or the like can be increased.", "Note that a material whose properties are changed by reaction with a different material can be interposed between or covered with materials which do not easily react with the different material.", "For example, in the case where ITO and aluminum are connected to each other, titanium, molybdenum, or an alloy of neodymium can be interposed between ITO and aluminum.", "For example, in the case where silicon and aluminum are connected to each other, titanium, molybdenum, or an alloy of neodymium can be interposed between silicon and aluminum.", "Note that such a material can be used for a wiring, an electrode, a conductive layer, a conductive film, a terminal, a via, a plug, or the like.", "Note that in the case where the above-described conductive film is formed to have a layered structure, for example, a structure in which Al is sandwiched between Mo, Ti, or the like is preferable.", "Thus, the resistance of Al to heat or chemical reaction can be improved.", "For each of the insulating layer 5265, the insulating layer 5267, the insulating layer 5269, the insulating layer 5305, and the insulating layer 5358, an insulating film having a single-layer structure or a layered structure, or the like can be used, for example.", "For example, as the insulating film, an insulating film containing oxygen or nitrogen, such as silicon oxide (SiOx), silicon nitride (SiNx), silicon oxynitride (SiOxNy) (x>y), or silicon nitride oxide (SiNxOy) (x>y); a film containing carbon such as diamond-like carbon (DLC); an organic material such as a siloxane resin, epoxy, polyimide, polyamide, polyvinyl phenol, benzocyclobutene, or acrylic; or the like can be used.", "For the light-emitting layer 5270, an organic EL element, an inorganic EL element, or the like can be used, for example.", "For the organic EL element, for example, a single-layer structure or a layered structure of a hole injection layer formed using a hole injection material, a hole transport layer formed using a hole transport material, a light-emitting layer formed using a light-emitting material, an electron transport layer formed using an electron transport material, an electron injection layer formed using an electron injection material, or a layer in which a plurality of these materials are mixed can be used.", "Note that an insulating layer which functions as an alignment film, an insulating layer which functions as a protrusion portion, or the like can be formed over the insulating layer 5305 and the conductive layer 5306.Note that an insulating layer or the like which functions as a color filter, a black matrix, or a protrusion portion can be formed over the conductive layer 5308.An insulating layer which functions as an alignment film can be formed below the conductive layer 5308.Note that the insulating layer 5269, the light-emitting layer 5270, and the conductive layer 5271 can be eliminated in the cross-sectional structure in FIG.", "32A, and the liquid crystal layer 5307 and the conductive layer 5308 which are illustrated in FIG.", "32B can be formed over the insulating layer 5267 and the conductive layer 5268.Note that the liquid crystal layer 5307 and the conductive layer 5308 can be eliminated in the cross-sectional structure in FIG.", "32B, and the insulating layer 5269, the light-emitting layer 5270, and the conductive layer 5271 which are illustrated in FIG.", "32A can be formed over the insulating layer 5305 and the conductive layer 5306.Note that in the cross-sectional structure in FIG.", "32C, the insulating layer 5269, the light-emitting layer 5270, and the conductive layer 5271 which are illustrated in FIG.", "32A can be formed over the insulating layer 5358 and the conductive layer 5359.Alternatively, the liquid crystal layer 5307 and the conductive layer 5308 which are illustrated in FIG.", "32B can be formed over the insulating layer 5267 and the conductive layer 5268.The shift register in this embodiment can be used for the semiconductor device, shift register, or display device in Embodiments 1 to 8.In specific, in the case where a non-single crystal semiconductor, microcrystalline semiconductor, an organic semiconductor, an oxide semiconductor, or the like is used as a semiconductor layer of the transistor in FIG.", "32B, the transistor deteriorates in some cases.", "In such a case too, deterioration of the transistor can be suppressed in the semiconductor, shift register, or display device in Embodiments 1 to 8.Embodiment 10 In this embodiment, examples of electronic devices are described.", "FIGS.", "33A to 33H and FIGS.", "34A to 34D are diagrams illustrating electronic devices.", "These electronic devices can each include a housing 5000, a display portion 5001, a speaker 5003, an LED lamp 5004, an operation key 5005, a connecting terminal 5006, a sensor 5007 (a sensor having a function of measuring force, displacement, position, speed, acceleration, angular velocity, rotational frequency, distance, light, liquid, magnetism, temperature, chemical substance, sound, time, hardness, electric field, current, voltage, electric power, radiation, flow rate, humidity, gradient, oscillation, odor, or infrared rays), a microphone 5008, and the like.", "FIG.", "33A is a mobile computer which can include a switch 5009, an infrared rays port 5010, and the like in addition to the above-described objects.", "FIG.", "33B illustrates a portable image reproducing device (e.g., a DVD reproducing device) provided with a memory medium, which can include a second display portion 5002, a memory medium reading portion 5011, and the like in addition to the above objects.", "FIG.", "33C illustrates a goggle-type display which can include the second display portion 5002, a supporting portion 5012, an earphone 5013, and the like in addition to the above objects.", "FIG.", "33D illustrates a portable game machine which can include the memory medium reading portion 5011 and the like in addition to the above objects.", "FIG.", "33E is a projector which can include a light source 5033, a projecting lens 5034, and the like in addition to the above-described objects.", "FIG.", "33F is a portable game machine which can include a second display portion 5002, a memory medium reading portion 5011, and the like in addition to the above-described objects.", "FIG.", "33G is a television receiver which can include a tuner, an image processing portion, and the like in addition to the above-described objects.", "FIG.", "33H illustrates a portable television receiver which can include a charger 5017 which can transmit and receive signals and the like in addition to the above objects.", "FIG.", "34A illustrates a display which can include a supporting board 5018 and the like in addition to the above objects.", "FIG.", "34B is a camera which can include an external connecting port 5019, a shutter button 5015, an image receiver portion 5016, and the like in addition to the above-described objects.", "FIG.", "34C is a computer which can include a pointing device 5020, an external connecting port 5019, a reader/writer 5021, and the like in addition to the above-described objects.", "FIG.", "34D illustrates a mobile phone which can include an antenna 5014, a tuner of one-segment partial reception service for mobile phones and mobile terminals (“1seg”), and the like in addition to the above objects.", "The electronic devices shown in FIGS.", "33A to 33H and FIGS.", "34A to 34D can have a variety of functions.", "For example, a function of displaying a variety of information (a still image, a moving image, a text image, and the like) on a display portion, a touch panel function, a function of displaying a calendar, date, time, and the like, a function of controlling processing with a variety of software (programs), a wireless communication function, a function of being connected to a variety of computer networks with a wireless communication function, a function of transmitting and receiving a variety of data with a wireless communication function, and a function of reading program or data stored in a memory medium and displaying the program or data on a display portion can be given.", "Further, the electronic device including a plurality of display portions can have a function of displaying image information mainly on one display portion while displaying text information on another display portion, a function of displaying a three-dimensional image by displaying images where parallax is considered on a plurality of display portions, or the like.", "Furthermore, the electronic device including an image receiver portion can have a function of shooting a still image, a function of shooting a moving image, a function of automatically or manually correcting a shot image, a function of storing a shot image in a memory medium (an external memory medium or a memory medium incorporated in the camera), a function of displaying a shot image on the display portion, or the like.", "Note that functions which can be provided for the electronic devices shown in FIGS.", "33A to 33H and FIGS.", "34A to 34D are not limited thereto, and the electronic devices can have a variety of functions.", "Electronic devices described in this embodiment are characterized by having a display portion for displaying some sort of information.", "By a combination of the electronic device in this embodiment and the semiconductor device, shift register, or display device in Embodiments 1 to 9, improvement in reliability, improvement in yield, reduction in cost, increase in the size of the display portion, increase in the definition of the display portion, or the like can be achieved.", "Next, application examples of a semiconductor device are described.", "FIG.", "34E shows an example in which a semiconductor device is provided so as to be integrated with a building.", "In FIG.", "34E, a housing 5022, a display portion 5023, a remote controller device 5024 which is an operation portion, a speaker 5025, and the like are included.", "The semiconductor device is incorporated in the constructed object as a wall-hanging type and can be provided without requiring a large space.", "FIG.", "34F illustrates an example where a semiconductor device is incorporated in a constructed object.", "The display panel 5026 is integrated with a prefabricated bath 5027, so that a person who takes a bath can watch the display panel 5026.Note that although this embodiment gives the wall and the prefabricated bath as examples of the building, this embodiment is not limited to them and the semiconductor device can be provided in a variety of buildings.", "Next, examples where a semiconductor device is incorporated with a moving object are described.", "FIG.", "34G illustrates an example in which the semiconductor device is provided in a vehicle.", "A display panel 5028 is provided in a body 5029 of the vehicle and can display information input from the operation of the body or the outside of the body on demand.", "Note that a navigation function may be provided.", "FIG.", "34H shows an example in which the semiconductor device is provided so as to be integrated with a passenger airplane.", "FIG.", "34H shows a usage pattern when a display panel 5031 is provided on a ceiling 5030 above a seat in the passenger airplane.", "The display panel 5031 is integrated with the ceiling 5030 through a hinge portion 5032, and a passenger can watch the display panel 5031 by extending and contracting the hinge portion 5032.The display panel 5031 has a function of displaying information when operated by the passenger.", "Note that although this embodiment gives the body of the vehicle and the body of the plane as examples of the moving body, this embodiment is not limited thereto.", "The semiconductor device can be provided to a variety of moving bodies such as a two-wheel motor vehicle, a four-wheel vehicle (including a car, bus, and the like), a train (including a monorail, a railway, and the like), and a ship.", "This application is based on Japanese Patent Application serial No.", "2008-304124 filed with Japan Patent Office on Nov. 28, 2008, the entire contents of which are hereby incorporated by reference." ] ]
Patent_15874245
[ [ "AIRCRAFT FLOOR INCORPORATING A GROUND PLANE", "A system for shielding of at least one component within an aircraft includes a floor panel disposed at least partially between joists supporting a floor within the aircraft and a ground plane connected to a bottom surface of the floor panel.", "The ground plane extends at least partially between adjacent joists.", "At least one bracket electrically connects the ground plane to at least one of the joists." ], [ "1-11.", "(canceled) 12.A bracket for connecting a ground plane to a joist for shielding of at least one component within an aircraft, comprising: a body defining a first end and a second end, wherein the first end connects to a ground plane and wherein the second end connects to the joist; at least one first fastener connecting the first end to the ground plane; at least one second fastener connecting the second end to the joist; a spacer connected to the first end, establishing a contact surface between the spacer and the ground plane; and a seal surrounding the spacer.", "13.The bracket of claim 12, wherein the spacer comprises: an electrically conductive material.", "14.The bracket of claim 12, wherein the bracket comprises metal.", "15.The bracket of claim 12, wherein the spacer comprises: a peripheral portion; and an inner portion with a thickness greater than that of the peripheral portion.", "16.The bracket of claim 12, wherein the seal comprises an elastomeric material.", "17.The bracket of claim 12, wherein the ground plane shields the at least one component from at least one of electromagnetic and radio frequency interference." ], [ "<SOH> FIELD OF THE INVENTION <EOH>The present invention concerns a construction incorporating a protective ground plane into a floor panel of an aircraft, a bracket for connecting the ground plane to a joist supporting a floor panel in an aircraft, and a system combining the ground plane and bracket for grounding the ground plane within an aircraft.", "The ground plane is contemplated to provide isolation from electromagnetic and radio frequency sources, among other types of electrical protection." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention addresses one or more of the deficiencies noted with respect to the prior art.", "In one contemplated embodiment, the present invention provides a system for shielding of at least one component within an aircraft.", "The system includes a floor panel disposed at least partially between joists supporting a floor within the aircraft, a ground plane connected to a bottom surface of the floor panel, the ground plane extending at least partially between adjacent joists, and at least one bracket electrically connecting the ground plane to at least one of the joists.", "In another embodiment of the system of the present invention, the ground plane shields the at least one component from at least one of electromagnetic and radio frequency interference.", "It is contemplated that the ground plane is made of a plate of electrically conductive material and at least one hole provided in the plate to lighten the total weight of the plate.", "The hole is sized for shielding of the at least one component, accommodating at least one of frequency and wavelength of impingent radiation upon the at least one component.", "It is calculated that the hole is no more than about 1/10 th of the size of a minimum wavelength of the impingent radiation.", "The bracket that forms a part of the invention includes a body defining a first end and a second end.", "The first end connects to a ground plane and the second end connects to the joist.", "At least one first fastener connects the first end to the ground plane.", "At least one second fastener connects the second end to the joist.", "A spacer connects to the first end, establishing a contact surface between the spacer and the ground plane.", "A seal surrounds the spacer.", "Another embodiment of the present invention provides a ground plane for shielding of at least one component within an aircraft.", "The ground plane includes a plate of electrically conductive material, and at least one hole provided in the plate to lighten the total weight of the plate.", "The hole is sized for shielding of the at least one component, accommodating at least one of frequency and wavelength of impingent radiation upon the at least one component.", "As noted, the hole may be no more than about 1/10 th of the size of a wavelength of the impingent radiation.", "In one embodiment, the hole is about 1.2 inches in diameter.", "It is contemplated that the ground plane shields the at least one component from at least one of electromagnetic and radio frequency interference.", "The component may be a wire bundle disposed adjacent to the ground plane.", "The ground plane is contemplated to be made from metal.", "The present invention also provides a bracket for connecting a ground plane to a joist for shielding of at least one component within an aircraft.", "The bracket includes a body defining a first end and a second end, wherein the first end connects to a ground plane and wherein the second end connects to the joist, at least one first fastener connecting the first end to the ground plane, at least one second fastener connecting the second end to the joist, a spacer connected to the first end, establishing a contact surface between the spacer and the ground plane, and a seal surrounding the spacer.", "The spacer is contemplated to be made from an electrically conductive material.", "The bracket is contemplated to be made from metal.", "The spacer is contemplated to include a peripheral portion and an inner portion with a thickness greater than that of the peripheral portion.", "The seal surrounding the spacer is contemplated to be made from an elastomeric material.", "Further aspects of the present invention will be made apparent form the paragraphs that follow." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS AND CLAIM OF PRIORITY This application is a Divisional of U.S. patent application Ser.", "No.", "14/772,429 filed on Feb. 26, 2014, which is a national phase application under 35 U.S.C.", "371 of International Patent Application No.", "PCT/IB2014/000209 filed on Feb. 26, 2014, which claims priority to U.S. provisional patent application no.", "61/773,441 filed on Mar.", "6, 2013, the entire contents of which are hereby incorporated by reference.", "FIELD OF THE INVENTION The present invention concerns a construction incorporating a protective ground plane into a floor panel of an aircraft, a bracket for connecting the ground plane to a joist supporting a floor panel in an aircraft, and a system combining the ground plane and bracket for grounding the ground plane within an aircraft.", "The ground plane is contemplated to provide isolation from electromagnetic and radio frequency sources, among other types of electrical protection.", "DESCRIPTION OF THE RELATED ART In the construction of traditional aircraft, it has been the practice of aircraft manufacturers to place wire bundles at strategic locations within the fuselage of the aircraft.", "The wire bundles include wires that provide power to various devices located on the aircraft.", "The wires also carry electrical signals between devices located on the aircraft and, therefore, provide electronic communication between those various devices.", "As should be apparent to those skilled in the art, it is known to provide electrical shielding for the wire bundles within the aircraft.", "Electrical protection (or shielding) encompasses insulating (or isolating) wires from interference from one or more sources of electromagnetic and/or radio frequency sources.", "With respect to electromagnetic and radio frequency transmissions, it should be apparent that there are various sources of potentially interfering signals.", "Interference may be generated by components that are part of the aircraft.", "Separately, passengers and crew members may bring devices on board the aircraft (i.e., cellular telephones, tablets, computers, etc.)", "that may generate electromagnetic (“EM”) and/or radio frequency (“RF”) signals that have the potential to interfere with signals transmitted along the wire bundles.", "A third potential source of EM and RF signals are those generated exterior to the aircraft.", "For example, communications towers (i.e., cellular towers, radio towers, etc.)", "may generate signals that are of sufficient strength to interfere with aircraft systems, even from an appreciable distance.", "A simple way to provide electrical protection for one or more wires is to position the wires near to a grounded, electrically conductive substrate.", "Typically, the substrate is made from metal, because metal materials are excellent conductors.", "In addition, metal materials function well to protect electrical signals in wires from being influenced by EM and RF interference.", "As should be apparent to those skilled in the art, the skin of traditional aircraft is made from aluminum or an alloy of aluminum.", "Being made from metal, the skin of the traditional aircraft offers a convenient surface against which wire bundles may be positioned.", "As a result, it has been common practice to lay wire bundles adjacent to (or in close proximity) to the interior surface of the skin of the aircraft.", "By positioning the wire bundles adjacent to the skin of the aircraft, the traditional aircraft designer has been able to provide EM and RF shielding for those wires.", "More and more, modern aircraft incorporate non-metallic components.", "For example, modern aircraft incorporate carbon fiber composite materials into at least some of the panels forming the skin and other structural components.", "Carbon fiber composite materials are not particularly conductive when compared to metals.", "As a general rule, carbon fiber materials are about one thousand times (1000×) less conductive than metals.", "Carbon fiber materials, therefore, are inadequate for shielding wires from EM and RF interference.", "As should be apparent, with the substitution of carbon fiber composite materials for metal in modern aircraft, the skin of the aircraft may no longer act as a suitable ground location, to establish an EM shield and/or RF shield for the wire bundles positioned adjacent thereto.", "Separately, given the space requirements in aircraft, it is contemplated that the wire bundles may not be placed adjacent to the skin of the aircraft, even where the aircraft is made entirely from metal.", "As a result, a need has developed for a light-weight EM/RF shield for electrical wire bundles disposed within the aircraft, regardless of the positioning of the wire bundles in the aircraft.", "In other words, a need developed a way to shield electrical wires regardless of their position within the aircraft.", "SUMMARY OF THE INVENTION The present invention addresses one or more of the deficiencies noted with respect to the prior art.", "In one contemplated embodiment, the present invention provides a system for shielding of at least one component within an aircraft.", "The system includes a floor panel disposed at least partially between joists supporting a floor within the aircraft, a ground plane connected to a bottom surface of the floor panel, the ground plane extending at least partially between adjacent joists, and at least one bracket electrically connecting the ground plane to at least one of the joists.", "In another embodiment of the system of the present invention, the ground plane shields the at least one component from at least one of electromagnetic and radio frequency interference.", "It is contemplated that the ground plane is made of a plate of electrically conductive material and at least one hole provided in the plate to lighten the total weight of the plate.", "The hole is sized for shielding of the at least one component, accommodating at least one of frequency and wavelength of impingent radiation upon the at least one component.", "It is calculated that the hole is no more than about 1/10th of the size of a minimum wavelength of the impingent radiation.", "The bracket that forms a part of the invention includes a body defining a first end and a second end.", "The first end connects to a ground plane and the second end connects to the joist.", "At least one first fastener connects the first end to the ground plane.", "At least one second fastener connects the second end to the joist.", "A spacer connects to the first end, establishing a contact surface between the spacer and the ground plane.", "A seal surrounds the spacer.", "Another embodiment of the present invention provides a ground plane for shielding of at least one component within an aircraft.", "The ground plane includes a plate of electrically conductive material, and at least one hole provided in the plate to lighten the total weight of the plate.", "The hole is sized for shielding of the at least one component, accommodating at least one of frequency and wavelength of impingent radiation upon the at least one component.", "As noted, the hole may be no more than about 1/10th of the size of a wavelength of the impingent radiation.", "In one embodiment, the hole is about 1.2 inches in diameter.", "It is contemplated that the ground plane shields the at least one component from at least one of electromagnetic and radio frequency interference.", "The component may be a wire bundle disposed adjacent to the ground plane.", "The ground plane is contemplated to be made from metal.", "The present invention also provides a bracket for connecting a ground plane to a joist for shielding of at least one component within an aircraft.", "The bracket includes a body defining a first end and a second end, wherein the first end connects to a ground plane and wherein the second end connects to the joist, at least one first fastener connecting the first end to the ground plane, at least one second fastener connecting the second end to the joist, a spacer connected to the first end, establishing a contact surface between the spacer and the ground plane, and a seal surrounding the spacer.", "The spacer is contemplated to be made from an electrically conductive material.", "The bracket is contemplated to be made from metal.", "The spacer is contemplated to include a peripheral portion and an inner portion with a thickness greater than that of the peripheral portion.", "The seal surrounding the spacer is contemplated to be made from an elastomeric material.", "Further aspects of the present invention will be made apparent form the paragraphs that follow.", "BRIEF DESCRIPTION OF THE DRAWING(S) The present invention will now be described in connection with the drawing appended hereto, in which: FIG.", "1 is a perspective illustration of an aircraft that incorporates the features of the present invention; FIG.", "2 is a graphical cross-section of an aircraft fuselage, illustrating a conventional location for the placement of wire bundles within the aircraft fuselage; FIG.", "3 is a graphical cross-section of the aircraft fuselage of the present invention, illustrating at least one challenge associated with the placement of wire bundles within the interior of the aircraft; FIG.", "4 is a graphical cross-section of the aircraft fuselage of the present invention, showing at least one contemplated placement of ground plane(s) beneath the floor of the aircraft's cabin; FIG.", "5 is a perspective illustration of one embodiment of the ground plane and bracket(s) of the present invention; FIG.", "6 is an enlarged, cross-sectional view of embodiment of the ground plane and brackets illustrated in FIG.", "5; FIG.", "7 is a perspective, top view of one of the brackets illustrated in FIG.", "6, with the floor panel having been removed for clarity; and FIG.", "8 is a graphical top view, showing two implementations of the ground panel and brackets of the present invention.", "DETAILED DESCRIPTION OF EMBODIMENT(S) OF THE INVENTION The present invention will now be described in connection with one or more embodiments thereof.", "The discussion of any particular embodiment is not intended to be limiting of the present invention.", "To the contrary, the discussion of selected embodiments is intended to exemplify the breadth and scope of the present invention.", "As should be apparent to those skilled in the art, variations and equivalents of the embodiment(s) described herein may be employed without departing from the scope of the present invention.", "Those variations and equivalents are intended to be encompassed by the scope of the present patent application.", "The present invention will now be discussed in the content of the construction of an aircraft 10, such as the one illustrated in the perspective view provided in FIG.", "1.FIG.", "1 is a perspective illustration of an aircraft 10 to which the present invention applies.", "The aircraft 10 includes a fuselage 12 defining a forward end 14 and a rear (or aft) end 16.Two wings 18, 20 extend laterally from the fuselage 12.A tail section 22 is attached to the rear end 16 of the aircraft.", "As should be apparent to those skilled in the art, the wings 18, 20 and the tail section 22 incorporate multiple control surfaces that are responsible for flying characteristics and flight operations of the aircraft 10.Two engines 24, 26 are suspended from and connect to the wings 18, 20, as illustrated.", "As discussed above, all aircraft 10 include wire bundles 28 that perform at least two primary functions.", "Some of the wires in the wire bundles transfer power to one or more of the operational components within the aircraft 10.Others of the wires transmit electrical signals that are processed by one or more of the devices on the aircraft 10.As a result, it is desirable to provide shielding so that the wires in the wire bundles 28 are insulated (or isolated) from EM and RF influences.", "As should be apparent to those skilled in the art, EM and RF influences (among other variables) may impact upon the performance and/or operation of the wires in the wire bundles 28 in addition to interfering with one or more components on board the aircraft.", "FIG.", "2 is a graphical cross-section of a conventional aircraft 10.A floor 30 of the cabin 32 is provided for reference.", "As illustrated, wire bundles 28 are positioned adjacent to the interior surface 34 of the fuselage 12.The wire bundles 28 extend along the length of the aircraft 10 from a position near to the front end 14 to a position near to the rear end 16.As noted above, in the conventional aircraft 10, the skin 36 of the aircraft 10 is made from a metal, in particular aluminum or an aluminum alloy.", "The metal skin 36, therefore, provides a convenient location for the placement of the wire bundles 28 thereagainst.", "The skin 36 of the aircraft 10 provides shielding from EM and RF sources.", "As also discussed above, modern aircraft are, more and more, incorporating carbon fiber composite panels in lieu of aluminum parts.", "Carbon fiber panels, while lighter and (in some configurations) stronger than their aluminum counterparts, are not particularly conductive.", "As a general rule, carbon fiber composite components are about 1000 times less conductive than metals.", "As a result, carbon fiber components do not adequately shield the wire bundles 28 from EM and/or RF sources.", "FIG.", "3 is a graphical cross-section of the aircraft illustrated in FIG.", "1.This cross section is provided to assist with a discussion of specific aspects of the present invention.", "As should be apparent to those skilled in the art, the floor 30 is supported by joists 38, which are spaced from one another and extend along the longitudinal axis of the aircraft 10.Cross joists (not shown in this illustration) extend laterally between the sides of the fuselage 12 and connect the joists 38 together to form a checkerboard lattice under the floor 30 within the cabin 32 of the aircraft 10.As should be apparent to those skilled in the art, the joists 38 typically are made from metal, such as aluminum or an aluminum alloy.", "Being made from metal, the joists 38 provide at least a limited degree of grounding and protection against EM and RF interference.", "However, the distance 40 between the joists 38 exceeds the protective distance 42 established by the joists 38.As such, any wire bundles 28 that are positioned adjacent to the joists 38 will not benefit from protection from EM and RF interference because some portion of the wire bundles 28 will lie outside of the protective distance 42 established by the joists 38.FIG.", "4 illustrates one aspect of the present invention.", "Specifically, to provide protection from EM and RF interference (hereinafter referred to as “electrical protection”), the aircraft 10 of the present invention incorporates ground planes 44 that are positioned beneath the floor 30, above and adjacent to respective ones of the wire bundles 28.The ground planes 44 are contemplated to be made from a conductive material, such as metal.", "In the illustrated embodiment, the ground planes are made from aluminum or an aluminum alloy.", "The ground planes have a width 46 that is at least as wide as the adjacent wire bundle 28.The wire bundles 28 are positioned sufficiently close to the ground planes 44 so that they benefit from the electrical protection established by the ground planes 44.In the contemplated embodiment, the ground planes 44 have a width 46 that is greater than the widths of the wire bundles 28 disposed adjacent thereto.", "In an alternative embodiment, the ground planes 44 may have widths that are equal to the widths of the wire bundles 28.In a third contemplated embodiment, the ground planes 44 may have widths 46 that are less than the widths of the bundles 28 positioned adjacent thereto.", "In this third embodiment, it is understood that the ground planes 44 establish electrical protection that extends a distance from the edges thereof, just as the joists 38 establish a protective distance 42 therefrom.", "Relying on this aspect of the ground planes 44, it is contemplated that the ground planes 44 need not be as wide as the adjacent wire bundles 28.As also is illustrated in FIG.", "4, the ground planes 44 are contemplated to be interposed between the floor 30 (which is made from a matrix of floor panels 30 that are connected to the joists 38 and the cross joists (not shown in this view)) and the wire bundles 28.In an alternative embodiment, it is contemplated that the ground planes 44 may be positioned within the aircraft 10 such that the wire bundles 28 are positioned between the ground planes 40 and the floor 30 without departing from the scope of the present invention.", "It is noted that the floor panels 30 provide a convenient location for the location of the ground plane 44 of the present invention.", "In addition, the floor panels 30 are removable from the joists and cross-joists 48, thereby providing access to any wire bundles 28 positioned thereunder.", "FIG.", "5 is a perspective view showing one contemplated embodiment of the present invention.", "The perspective is taken from a vantage point beneath the floor 30 of the aircraft 10 looking upwardly at the bottom surface of one or more of the floor panels 30.The joists 38 are visible in this illustration, as is at least one of the cross joists 48.The ground plane 44 is visible beneath the floor 30.As should be apparent to those skilled in the art, the weight of components in the aircraft 10 is always a concern for aircraft designers.", "Specifically, aircraft designers endeavor to lighten aircraft components so that they present a minimal weight addition to the aircraft 10 while performing their intended function(s).", "This design consideration applies to the ground plane 44, just as it does with other aircraft components.", "So that the ground plane 44 offers sufficient electrical protection but does not add unnecessarily to the overall weight of the aircraft 10, the ground plane 44 is constructed to be thin and to include a plurality of holes 50 cut therethrough.", "With respect to the thickness of the ground plane 44, one embodiment contemplates that the ground plane 44 will be quite thin.", "For example, the ground plane 44 may be only ten one thousandths of an inch (0.01 inch; 0.254 mm) thick.", "It is contemplated that the ground plane 44 may be made thicker or thinner without departing from the scope of the present invention.", "Being so thin, the ground plane 44 is more like an aluminum foil, rather than a rigid plate of metal.", "Being so thin, the ground plane 44 preferably is affixed to the bottom surface of the floor 30 so that the ground plane 44 is not easily torn or damaged.", "It is contemplated that the ground plane 44 may be applied to the floor 30 as a coating during manufacture of the floor 30.Alternatively, the ground plane 44 may be affixed to the bottom of the floor 30 via any suitable adhesive or other suitable attachment means.", "As noted above, the ground plane 44 includes a plurality of holes 50 cut therethrough.", "The holes 50 have a diameter that does not exceed a maximum size required for electrical protection.", "One embodiment of the present invention contemplates that the holes 50 will have diameters of about 1.2 inches (3.05 cm).", "It is also contemplated that the distance between holes 50 will not be less than 1.2 inches (3.05 cm).", "This specific distance was selected based on calculations associated with the frequency and wavelength of the types of electrical threats anticipated to be present in the aircraft 10 (i.e., electronic devices) or in the environment through which the aircraft 10 travels (i.e., communications towers).", "It is noted that the holes are sized to accommodate specific wavelength (and frequencies) of EM and RF interference.", "The holes 50 have a diameter that is approximately 1/10 of the length of the shortest wavelength of the types of interfering EM and/or RF radiation that is anticipated to impinge thereon.", "Finally, while circular holes are illustrated, the holes 50 may have any shape without departing from the scope of the present invention.", "As should be apparent, the ground plane 44 of the present invention is not considered to be limited to this particular construction.", "Holes 50 with a larger or smaller diameter may be employed without departing from the scope of the present invention.", "Moreover, the distance between the holes may be larger or smaller than 1.2 inches (3.05 cm) without departing from the scope of the present invention.", "In one contemplated embodiment, the ground plane 44 does not include any holes 50.While this adds weight to the aircraft 10, a solid ground plane 44 offers maximum shielding protection to any wire bundles 28 positioned adjacent thereto.", "So that the ground plane 44 is electrically grounded within the aircraft 10, the ground plane 44 is connected to the joists 38 (or, alternatively, the cross joists 48) via one or more brackets 52.The brackets 52 are connected to the ground plane 44 and the floor 30 at a first end 54, via one or more fasteners 56.The brackets 52 are connected to the joists 38 at a second end 58 via one or more fasteners 60.At the first end 54, the bracket 52 and the ground plane 44 establish a metal-to-metal contact to ensure a reliable electrical connection therebetween.", "Similarly, at the second end 58, the bracket 52 and the joist 38 present a metal-to-metal contact to ensure a reliable, electrical contact therebetween.", "As such, the ground plane 44 is suitably grounded via the network of supports made up of the joists 38 and the cross joists 48 (among other components in the aircraft 10).", "In FIG.", "5, floor fasteners 62 also are illustrated.", "The floor fasteners 62 removably connect the floor panels 30 to the joists 38 and the cross joists 48.As should be apparent to those skilled in the art, the floor panels 30 are designed to be removable so that personnel may access the components (including the wire bundles 28) that are located beneath the floor 30.Such access may be needed, for example, to perform maintenance or repairs on the aircraft 10.So that the floor panels 30 may be disengaged from the brackets 52, the fasteners 56 also are removable.", "The second ends 58 of the brackets 52 are not contemplated to be removed easily from the joists 38 (or cross-joists 48) unless there is a need to replace one or more of the brackets 52.In other words, the brackets 52 in this embodiment are contemplated to remain affixed to the joists 38 after removal of one or more of the floor panels 30.FIG.", "6 is a cross-sectional view of a portion of the ground plane 44 of the present invention, the cross section being taken through one of the fasteners 56.The perspective is looking toward one of the joists 38 from the fastener 56.The fastener 56 extends through the floor panel 30 and the first end 54 of the bracket 52.The fastener 56 is surrounded by a seal 64 that extends through the floor panel 30.The seal 64 helps to protect the electrical connection between the ground plane 44 and the bracket 52.The first end 54 of the bracket 52 includes a spacer 66 that is connected to and extends upwardly from a top surface of the bracket 52.The spacer 66 includes a thin, peripheral portion 68 and a thicker, inner portion 70.The peripheral portion 68 of the spacer 66 is penetrated by at least one fastener 72 that connects the spacer 66 to the first end 54 of the bracket 52.As should be apparent, the illustrated embodiment provides room for two fasteners 72.While two fasteners 72 are illustrated, a larger or a fewer number may be used without departing from the scope of the present invention.", "The spacer 66 is electrically connected to the first end 54 of the bracket via a metal-to-metal contact.", "As should be apparent, the spacer 66 is made from metal, such as aluminum.", "However, the spacer 66 may be made from any other suitable, conductive material without departing from the scope of the present invention.", "The inner portion 70 of the spacer 66 establishes an electrical contact 74 between the bracket 52 and the ground plane 44.A seal 76, made from an elastomeric material such as rubber, surrounds the spacer 66.In addition to the seal 64, the seal 76 helps to protect the electrical contact between the spacer 66 and the ground plane 44.Specifically, the seal 76 discourages moisture and debris from entering the space around the spacer 64 and, thereby, protects the electrical connection 74 between the spacer 66 and the ground plane 44.FIG.", "7 is a perspective illustration of the bracket 52 illustrated in FIGS.", "5 and 6.The perspective is taken from above the bracket 52 with the floor panel 30 having been removed.", "FIG.", "8 is a graphical top view of two contemplated installations of the ground plane 44 according to the present invention.", "On the right hand side of FIG.", "8, the ground plane 44 extends nearly the full distance between adjacent joists 38.On the left hand side, the ground plane 44 extends partially between two adjacent joists 38.It is noted that the embodiment provided on the left hand side of FIG.", "8 includes extensions 78 that extend outwardly from the ground plane 44 to the edge of the floor plate 30 on which the ground plate 44 is disposed.", "The brackets 52 connect to the extensions 78 in the same manner as the brackets 52 connect to the ground plane 44.Specifically, the brackets 52 connect to the extensions 78 via one or more fasteners 56.In another contemplated embodiment, it is contemplated that the extensions 78 may be substituted by elongated brackets (not shown) that extend from the joists 38 (and/or cross-joists 48) to the ground plate 44.The elongated brackets (no shown) are, therefore, considered to fall within the scope of the present invention.", "In both embodiments, it is contemplated that four brackets 52 will connect between the joists 38 and the ground planes 44 at roughly the corners of the ground planes 44.This arrangement is preferred because the arrangement provides acceptable redundancy.", "Moreover, by connecting the brackets at the corners of the ground planes 44, a better distribution of electrical protection is established.", "As should be apparent, however, a larger or a smaller number of brackets 52 may be employed without departing from the scope of the present invention.", "As should be apparent from the foregoing, the present invention is contemplated to be disposed in an aircraft 10.The aircraft 10 may be made entirely with a metal skin, with a partially metal skin with nonmetal portions, or entirely from a non-metallic material such as carbon fiber composite.", "As noted above, the embodiment(s) described herein are intended to be exemplary of the wide breadth of the present invention.", "Variations and equivalents of the described embodiment(s) are intended to be encompassed by the present invention, as if described herein." ] ]
Patent_15874252
[ [ "VERTEBRAL IMPLANTS AND RELATED METHODS OF USE", "A vertebral insert may include a first linkage, a second linkage, and a third linkage.", "The first, second, and third linkages may at least partially defining a cavity.", "The insert may be movable between a collapsed configuration and an expanded configuration, and the movement of the first and second linkages with respect to one another may be configured to reciprocally move the insert between the collapsed and expanded configurations." ], [ "1.A vertebral insert, comprising: a first linkage, a second linkage, and a third linkage, the first, second, and third linkages at least partially defining a cavity, the insert being movable between a collapsed configuration and an expanded configuration, wherein the movement of the first and second linkages with respect to one another is configured to reciprocally move the insert between the collapsed and expanded configurations.", "2.The vertebral insert of claim 1, further including a fourth linkage coupled to at least the third linkage.", "3.The vertebral insert of claim 2, wherein the third and fourth linkages are buckled laterally inward in the collapsed configuration.", "4.The vertebral insert of claim 2, wherein the third and fourth linkages are bowed laterally outward in the expanded configuration.", "5.The vertebral insert of claim 1, wherein the first linkage includes an elongate portion that is slidable through a recess of the second linkage.", "6.The vertebral insert of 5, wherein the elongate portion is hollow.", "7.The vertebral insert of claim 5, further including a flange that extends outward from the elongate portion.", "8.The vertebral insert of claim 7, wherein the second linkage includes an end portion, and the flange of the first linkage is configured to directly abut the end portion of the second linkage when the device is in the expanded configuration.", "9.The vertebral insert of claim 5, wherein the elongate portion is configured to prevent the rotation of the first linkage with respect to the second linkage.", "10.The vertebral insert of claim 1, wherein a leading edge of the second linkage is wedged.", "11.The vertebral insert of claim 1, wherein the movement of the first and second linkages with respect to one another is a linear movement.", "12.The vertebral insert of claim 1, wherein the first and second linkages are generally linear and the third linkage is generally arcuate.", "13.The vertebral insert of claim 1, where in the movement of the third linkage is a with respect to the second linkage is a rotational movement.", "14.A method of installing an expandable vertebral insert, the method comprising: inserting the vertebral insert between two vertebral bodies while the vertebral insert is in a collapsed configuration, wherein the vertebral insert includes a first linkage, a second linkage, and a third linkage, the first, second, and third linkages at least partially defining a cavity, the insert being movable between a collapsed configuration and an expanded configuration, wherein the movement of the first and second linkages with respect to one another is configured to reciprocally move the insert between the collapsed and expanded configurations; and expanding the vertebral insert to an expanded configuration such that a cavity defined by the vertebral insert is larger in the expanded configuration than in the collapsed configuration.", "15.The method of claim 14, wherein a superior-inferior dimension of the vertebral insert is the same in both the collapsed configuration and the expanded configuration.", "16.The method of claim 14, further including packing the cavity with bone graft or bone-growth inducing material when the vertebral insert is in the expanded configuration.", "17.The method of claim 14, wherein expanding the vertebral insert includes longitudinally advancing a drive member coupled to a linkage of the vertebral insert." ], [ "<SOH> BACKGROUND <EOH>A common procedure for handling pain associated with intervertebral discs that have become degenerated due to various factors such as trauma or aging is the use of intervertebral spacers to fuse, e.g., one or more adjacent vertebral bodies.", "Generally, to fuse the adjacent vertebral bodies, the native intervertebral disc is first partially or fully removed.", "An intervertebral spacer is then typically inserted between neighboring vertebrae to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion.", "There are a number of known conventional intervertebral spacers and methodologies in the art for accomplishing the vertebral fusion.", "These include screw and rod arrangements, solid bone implants, and intervertebral spacers which include a cage or other implant mechanism which, typically, may be packed with bone and/or bone-growth inducing substances.", "These devices are implanted between adjacent vertebral bodies in order to fuse the vertebral bodies together, potentially alleviating any associated pain.", "However, there are drawbacks associated with the known conventional intervertebral spacers and methodologies.", "For example, some conventional intervertebral spacers may lack sufficient surface area to optimally fuse adjacent vertebral bodies." ], [ "<SOH> SUMMARY OF THE DISCLOSURE <EOH>The present disclosure relates to examples of interbody vertebral inserts and related methods of use.", "In one aspect, the present disclosure is directed to a vertebral insert.", "The vertebral insert may include a first linkage, a second linkage, and a third linkage.", "The first, second, and third linkages may at least partially defining a cavity.", "The insert may be movable between a collapsed configuration and an expanded configuration, and the movement of the first and second linkages with respect to one another may be configured to reciprocally move the insert between the collapsed and expanded configurations.", "In another aspect, the present disclosure is directed to a method of installing an expandable vertebral insert.", "The method may include inserting the vertebral insert between two vertebral bodies while the vertebral insert is in a collapsed configuration.", "The vertebral insert may include a first linkage, a second linkage, and a third linkage.", "The first, second, and third linkages may at least partially define a cavity.", "The insert may be movable between a collapsed configuration and an expanded configuration.", "The movement of the first and second linkages with respect to one another may be configured to reciprocally move the insert between the collapsed and expanded configurations.", "The method also may include expanding the vertebral insert to an expanded configuration such that a cavity defined by the vertebral insert is larger in the expanded configuration than in the collapsed configuration.", "In yet another aspect, the present disclosure is directed to a vertebral insert.", "The vertebral insert may include a support member having a superior surface, an inferior surface, a first groove disposed between the superior surface and inferior surface on a first lateral side, a second groove disposed between the superior surface and inferior surface on a second lateral side, and a first keel extending from one of the superior and inferior surfaces.", "The vertebral insert also may include a first lateral spacer having a portion configured to extend within the first groove, and a second lateral spacer having a portion configured to extend within the second groove.", "In yet another aspect, the present disclosure is directed to a vertebral spacer system.", "The system may include a vertebral spacer, and a bracket coupled to the vertebral spacer.", "The system also may include a first plate, and a second plate coupled to the first plate and the bracket.", "The second plate may be movable relative to the first plate, and the second plate may define a cavity through which the vertebral spacer extends.", "In yet another aspect, the present disclosure is directed to a method of treating a patient.", "The method may include attaching a first plate to a first vertebral body, and attaching a second plate to a second vertebral body.", "The first plate and the second plate may be coupled to one another.", "The method also may include moving the first and second plates away from one another to distract the first and second vertebral bodies, and inserting a vertebral insert through a cavity defined by the second plate.", "In yet another aspect, the present disclosure is directed to a method of treating a patient.", "The method may include inserting a vertebral insert into the intervertebral space between two adjacent vertebral bodies, and expanding the vertebral insert to distract the adjacent vertebral bodies.", "The method also may include inserting a spacer into the intervertebral space, and laterally coupling the spacer to the vertebral insert after expanding the vertebral insert." ], [ "CROSS-REFERENCE TO RELATED APPLICATION The present application is a continuation application of U.S. Ser.", "No.", "14/466,632, filed Aug. 22, 2014, the entire disclosure of which is incorporated herein by reference in its entirety for all purposes.", "FIELD OF THE INVENTION Various examples of the present disclosure relate generally to vertebral inserts, such as, e.g., fusion devices and related systems and methods.", "More specifically, the present disclosure relates to vertebral inserts, devices, systems, and methods for repairing and/or replacing intervertebral discs of a patient.", "BACKGROUND A common procedure for handling pain associated with intervertebral discs that have become degenerated due to various factors such as trauma or aging is the use of intervertebral spacers to fuse, e.g., one or more adjacent vertebral bodies.", "Generally, to fuse the adjacent vertebral bodies, the native intervertebral disc is first partially or fully removed.", "An intervertebral spacer is then typically inserted between neighboring vertebrae to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion.", "There are a number of known conventional intervertebral spacers and methodologies in the art for accomplishing the vertebral fusion.", "These include screw and rod arrangements, solid bone implants, and intervertebral spacers which include a cage or other implant mechanism which, typically, may be packed with bone and/or bone-growth inducing substances.", "These devices are implanted between adjacent vertebral bodies in order to fuse the vertebral bodies together, potentially alleviating any associated pain.", "However, there are drawbacks associated with the known conventional intervertebral spacers and methodologies.", "For example, some conventional intervertebral spacers may lack sufficient surface area to optimally fuse adjacent vertebral bodies.", "SUMMARY OF THE DISCLOSURE The present disclosure relates to examples of interbody vertebral inserts and related methods of use.", "In one aspect, the present disclosure is directed to a vertebral insert.", "The vertebral insert may include a first linkage, a second linkage, and a third linkage.", "The first, second, and third linkages may at least partially defining a cavity.", "The insert may be movable between a collapsed configuration and an expanded configuration, and the movement of the first and second linkages with respect to one another may be configured to reciprocally move the insert between the collapsed and expanded configurations.", "In another aspect, the present disclosure is directed to a method of installing an expandable vertebral insert.", "The method may include inserting the vertebral insert between two vertebral bodies while the vertebral insert is in a collapsed configuration.", "The vertebral insert may include a first linkage, a second linkage, and a third linkage.", "The first, second, and third linkages may at least partially define a cavity.", "The insert may be movable between a collapsed configuration and an expanded configuration.", "The movement of the first and second linkages with respect to one another may be configured to reciprocally move the insert between the collapsed and expanded configurations.", "The method also may include expanding the vertebral insert to an expanded configuration such that a cavity defined by the vertebral insert is larger in the expanded configuration than in the collapsed configuration.", "In yet another aspect, the present disclosure is directed to a vertebral insert.", "The vertebral insert may include a support member having a superior surface, an inferior surface, a first groove disposed between the superior surface and inferior surface on a first lateral side, a second groove disposed between the superior surface and inferior surface on a second lateral side, and a first keel extending from one of the superior and inferior surfaces.", "The vertebral insert also may include a first lateral spacer having a portion configured to extend within the first groove, and a second lateral spacer having a portion configured to extend within the second groove.", "In yet another aspect, the present disclosure is directed to a vertebral spacer system.", "The system may include a vertebral spacer, and a bracket coupled to the vertebral spacer.", "The system also may include a first plate, and a second plate coupled to the first plate and the bracket.", "The second plate may be movable relative to the first plate, and the second plate may define a cavity through which the vertebral spacer extends.", "In yet another aspect, the present disclosure is directed to a method of treating a patient.", "The method may include attaching a first plate to a first vertebral body, and attaching a second plate to a second vertebral body.", "The first plate and the second plate may be coupled to one another.", "The method also may include moving the first and second plates away from one another to distract the first and second vertebral bodies, and inserting a vertebral insert through a cavity defined by the second plate.", "In yet another aspect, the present disclosure is directed to a method of treating a patient.", "The method may include inserting a vertebral insert into the intervertebral space between two adjacent vertebral bodies, and expanding the vertebral insert to distract the adjacent vertebral bodies.", "The method also may include inserting a spacer into the intervertebral space, and laterally coupling the spacer to the vertebral insert after expanding the vertebral insert.", "BRIEF DESCRIPTION OF THE FIGURES The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate various exemplary embodiments and together with the description, serve to explain the principles of the disclosed embodiments.", "FIG.", "1 is a perspective view of a vertebral insert in accordance with an example of the present disclosure.", "FIG.", "2 is a perspective view of a support member disposed between adjacent vertebral bodies in accordance with an example of the present disclosure.", "FIGS.", "3-9 depict an exemplary method of installing a vertebral insert in accordance with an example of the present disclosure.", "FIG.", "10 is an exploded view of a vertebral insert in accordance with an example of the present disclosure.", "FIG.", "11 is a top view of the vertebral insert of FIG.", "10 with an endplate removed.", "FIG.", "12 is perspective view of a vertebral insert in accordance with an example of the present disclosure.", "FIGS.", "13-16 depict an exemplary method of installing a vertebral insert in accordance with an example of the present disclosure.", "FIGS.", "17-20 depict a vertebral insert in accordance with an example of the present disclosure.", "FIG.", "21 is a perspective view of a spacer assembly in accordance with an example of the present disclosure.", "FIGS.", "22-24 are perspective views of a plate assembly in accordance with an example of the present disclosure.", "FIGS.", "25-27 are perspective views of a bracket and spacer in accordance with an example of the present disclosure.", "FIGS.", "28-36 depict an exemplary method of installing a spacer assembly in accordance with an example of the present disclosure.", "DETAILED DESCRIPTION Reference will now be made in detail to examples of the present disclosure, examples of which are illustrated in the accompanying drawings.", "Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts.", "A vertebral insert 100 shown in FIG.", "1 may extend from a first end 102 toward a second end 104, and include a support member 106, a first lateral insert 108 and a second lateral insert 110.Support member 106, and first and second lateral inserts 108, 110 may be formed from a rigid, bio-compatible material such as, e.g., titanium or polyetheretherketone (PEEK), among others.", "Support member 106 and first and second lateral inserts 108, 110 may be formed of the same or different materials.", "In one example, support member 106 may be formed from titanium while first and second lateral inserts 108, 110 are formed from PEEK.", "Components that contact bone, including support member 106, and first and second lateral inserts 108, 110, may be treated with a titanium and/or hydroxyapatite plasma spray coating to encourage bony on-growth, improving the strength and stability of the connection between the respective component and the underlying bone (e.g., a vertebral body).", "Any other suitable coating also may be provided on one or more surfaces of support member 106, and first and second lateral inserts 108, 110.Such coatings may include therapeutic and/or antibiotic agents, if desired.", "Support member 106 and first and second lateral inserts 108, 110 also may include radiopaque markings to facilitate in vivo visualization and insertion.", "Support member 106 may have an upper or superior surface 112 and a lower or inferior surface 113.In some examples, superior surface 112 and inferior surface 113 may be substantially parallel to one another, or may have another suitable relationship to one another.", "In one example, superior surface 112 and/or inferior surface 113 may have a substantially flat configuration.", "In some examples, superior surface 112 and/or inferior surface 113 may have a variable cross-section, such as, e.g., bi-convex, e.g., curved from left to right and front to back, or may have another suitable configuration.", "This curvature may give superior surface 112 and/or inferior surface 113 a partial dome or spherical shape.", "The curvature may be complementary to the natural curvature of an adjacent vertebral body and may provide for an anatomical fit between superior surface 112 and/or inferior surface 113 with a vertebral body (shown in FIG.", "2).", "Superior surface 112 and inferior surface 113 may be substantially similar to one another or may have different features.", "In one example, superior surface 112 and inferior surface 113 may be mirror images of one another.", "Superior surface 112 may be coupled to inferior surface 113 by a member 116.Superior surface 112, inferior surface 113, and member 116 may generally form an I-beam type configuration defining a first groove 198 and a second groove 199 (referring to FIG.", "2).", "That is, a groove 198 may be disposed between superior and inferior surfaces 112 and 113 at a first lateral side of vertebral insert 100, and a groove 199 may be formed between superior and inferior surfaces 112 and 113 at a second lateral side of vertebral insert 100.One or more keels 114 may be located on superior surface 112 and may extend away from superior surface 112 at an angle.", "In one embodiment, the one or more keels 114 may include a plurality of serrations or other geometric configurations.", "In the example shown in FIG.", "1, keel 114 may be formed at least partially from a substantially elongate member having one or more notches 117 disposed on an axial end surface of keel 114.However, in some examples, a plurality of keels that are longitudinally or laterally spaced from one another may extend away from superior surface 112.Once a discectomy has been completed, removing the damaged natural disc or damaged disc material, a groove or channel 180 (shown in FIG.", "3) may be cut into the vertebral body to receive keel 114.Keel 114 may be integrally formed with superior surface 112 or may alternatively be attached to superior surface 112 by a suitable securing mechanism, e.g., an adhesive.", "Keel 114 may have one more holes, e.g., through holes, or openings (not shown) perpendicular to the longitudinal axis of the keel.", "These holes or openings may provide an aperture for bony in-growth, which may strengthen the connection or interface between the endplate and the vertebral body.", "In some examples, a plurality of keels 114 may be arranged in a plurality of rows and/or columns, if desired, which can be inserted through a similarly arranged sequence of channels or grooves formed in a vertebral body.", "Keels 114 may include suitable coatings or other geometrical features (e.g., barbs or other protrusions) to promote bony in-growth/on-growth.", "In examples having a plurality of keels 114, each keel 114 may have varying lengths, widths, and/or other dimensions.", "One or more keels 115 (which may include one or more of the aforementioned features of keels 114) may be located on inferior surface 113 and may extend away from inferior surface 113 at an angle.", "Keel 114 may include a ramp 120 at the second, leading end 104 of vertebral insert 100.Superior surface 112 may include two inclined edges directed laterally inward toward a first longitudinal axis A at second, leading end 104.Longitudinal axis A may extend longitudinally through the longitudinal midsection of superior surface 112.A first inclined edge 130 of superior surface 112 may incline from a first lateral side of vertebral insert 100 toward longitudinal axis A, while a second inclined edge 132 of superior surface 112 may incline from a second lateral side of vertebral insert 100 toward longitudinal axis A. Ramp 120 and inclined edges 130 and 132 may generally converge at a point 134 disposed along longitudinal axis A.", "Keel 115 may include a ramp 136 (shown only in FIG.", "3) that may include one or more features of ramp 120 of keel 114.Inferior surface 113 may include a first inclined edge (not shown) and a second inclined edge 138 that may include one or more of the features of first and second inclined edges 130 and 132 of superior surface 112.The first inclined edge and second inclined edge 138 of keel 115 may converge toward a second longitudinal axis B. Longitudinal axis B may extend longitudinally through the longitudinal midsection of inferior surface 113.The first inclined edge and second inclined edge 138 of inferior surface 113 and ramp 136 of keel 115 may generally converge at a point 139 that is disposed along longitudinal axis B.", "The bladed or wedged formation of second, leading end 104 of vertebral insert 100 may form the leading insertion end of vertebral insert 100 (e.g., the end that enters the intervertebral space first).", "The bladed or wedged formations may possess a mechanical advantage over other configurations.", "More specifically, the bladed or wedged formations may reduce the amount of force required to insert vertebral insert 100 into a patient.", "Further, in some examples, the portion of support member 106 at first end 102 may be the trailing end of support member 106 (e.g., the end that enters the patient second or last).", "The trailing end of support member 106 may be inserted between vertebral bodies by any suitable mechanism including, e.g., hammering, sliding, pushing, or other mechanisms.", "First lateral spacer 108 may include an elongate member 163 that extends from a first, trailing end 160 toward a second, leading end 162.In some examples, elongate member 163 may be generally cuboid, although other suitable configurations, e.g., cylindrical or the like, are also contemplated.", "Elongate member 163 may cooperate with groove 198 or 199 to couple support member 106 with first lateral spacer 108.That is, elongate member 163 and groove 198 or 199 may form, e.g., a tongue and groove joint, although other suitable joints and mating relationships are also contemplated.", "A generally ellipsoid (or otherwise elongated) ring 165 may be partially defined by flange portions 170 and 172, and may extend from elongate member 163.The ellipsoid ring 165 may at least partially define the outer perimeter of a cavity 167.Cavity 167 may have a generally ellipsoidal (or otherwise elongated) cylindrical shape, although other suitable configurations are also contemplated.", "In some examples, the outer curvature of ellipsoid ring 165 may be determined by the posterior curvature of the vertebral bodies between which vertebral insert 100 is implanted.", "Cavity 167 may be filled with bone graft or similar bone-growth inducing material to further promote and facilitate the intervertebral fusion.", "Cavity 167, in one example, may be packed with bone graft or similar bone-growth inducing material to promote the growth of bone through and around the vertebral insert.", "Such bone graft may be packed into cavity 167, subsequent to, or during implantation of the vertebral insert 100.Second lateral spacer 110 may include an elongate member 143 that extends from a first, trailing end 140 toward a second, leading end 142 (referring to FIG.", "4).", "In some examples, elongate member 143 may be generally cuboid, although other suitable configurations, e.g., cylindrical, are also contemplated.", "Elongate member 143 may cooperate with groove 198 or 199 to couple support member 106 with second lateral spacer 110.That is, elongate member 143 and groove 198 or 199 may form, e.g., a tongue and groove joint, although other suitable joints and mating relationships are also contemplated.", "Flange portions 144, 146, and 148 may extend away from a lateral end surface of elongate member 143 in the superior and inferior directions forming a generally t-shaped cross section with elongate member 143.In some examples, flange portions 144, 146, and 148 may mate and/or cooperate with lateral end surfaces of superior surface 112 and inferior surface 113, respectively.", "A groove 150 may be disposed longitudinally between flange portions 144 and 146, while a groove 152 may be disposed between flange portions 146 and 148.It should be noted that while two grooves and three flanges are shown in some examples, any other suitable number of grooves and flanges alternatively may be utilized to improve graft area, and/or ease of machining, among other factors.", "An arc portion 154 may extend laterally outward between first end 140 and second end 142.Arc portion 154, flanges 144, 146, and 148, and grooves 150 and 152 may define a cavity 156.In some examples, flanges 144, 146, 148, and arc portion 154 may define a generally D-shaped ring.", "It should be noted that, in some examples, the curvature of arc portion 154 may approximate the anterior curvature of adjacent vertebral bodies between which vertebral insert 100 is inserted.", "Cavity 156 may be filled with bone graft or other bone-growth inducing material in a substantially similar manner as described with respect to cavity 167.In some examples, vertebral insert 100 may be delivered by a minimally invasive (MIS) lateral lumbar interbody fusion (LLIF) approach.", "Vertebral insert 100 may be configured to provide increased surface area over conventional vertebral inserts.", "Vertebral insert 100 may be self-distracting with the insertion of keels 114, 115, and may decrease the chance of subsidence.", "In some examples, vertebral insert 100 may not need additional fixation such as, e.g., plates or other locking systems because keels 114 and 115 may prevent vertebral insert 100 from backing out of the intervertebral space.", "That is, vertebral insert 100 may be a standalone implant.", "Vertebral insert 100 may provide improved spacer fit by allowing for anterior and posterior spacer selection.", "In some examples, vertebral insert 100 may provide increased total surface area contact with vertebral bodies while also engaging harder bone around the apophyseal ring.", "In still further examples, vertebral insert 100 may provide for increased amount of bone graft or bone-growth inducing substances to be utilized over conventional devices.", "FIGS.", "3-9 illustrate an exemplary installation sequence for vertebral insert 100.Initially, a groove 180 may be formed through the superior surface of a vertebral body 2.A groove 182 (shown only in FIG.", "9) also may be formed in the inferior surface of vertebral body 4.Keels 115 and 114 of support 106 then may be aligned with grooves 180 and 182, respectively.", "Support 106 then may be inserted between vertebral bodies 2 and 4 by a suitable mechanism to place keels 115 and 114 into the grooves formed in the vertebral bodies, and to place superior and inferior surfaces 112 and 113 into the intervertebral space.", "Once support 106 is secured between vertebral bodies 2 and 4, one or more lateral inserts (e.g., first and second lateral inserts 108, 110) may be aligned with one or more grooves 198, 199 of support 106 and inserted between vertebral bodies 2 and 4.It should be noted that any suitable lateral insert may be selected to mate with support 106.Thus, the use of support 106 may permit operator flexibility and discretion when installing vertebral insert 100.For example, one or both of first and second lateral spacers 108, 110 may include modifications to, e.g., outer curvature, height, lordosis correction, or other features depending on the specific geometry of vertebral bodies 2 and 4.In some examples, lateral spacers 108 and 110 may provide for a continuous amount of lordotic correction, or alternatively, may each be configured to provide a different amount of lordotic correction to various portions of the vertebral bodies.", "In some examples, vertebral insert 100 may provide a higher amount of height and lordotic correction by having separate anterior and posterior spacers.", "In some examples, vertebral insert 100 may allow for evenly distributed weight loads.", "Lateral spacers 108 and 110 may be secured between vertebral bodies 2 and 4 by any suitable mechanism.", "In one example, rotatable locking flanges or screws (not shown) may be disposed at the trailing end of support 106.After lateral spacers 108 and 110 are inserted between the vertebral bodies 2 and 4, the locking flanges or screws may be rotated into a locking position to prevent spacers 108 and 110 from backing out of the intervertebral space.", "FIGS.", "10 and 11 show different views of a vertebral insert 200, in accordance with a further aspect of the present disclosure.", "The vertebral insert 200 may include a body portion 202, a first endplate 204, a second endplate 206, a translation member 208, and an actuation member 210.Translation member 208 and actuation member 210 may cooperate to axially (e.g., vertically) move endplates 204 and 206 away from one another, thereby increasing the axial height of vertebral insert 200.The first endplate 204 can include a pair of openings 212 and 214 through which bone graft material can be received or deposited.", "Likewise, the second endplate 206 can have one or more similar openings.", "In addition to these features, the vertebral insert 200 may include an interference nut 216 that is operably attached to a rear section (e.g., a trailing end) of the body portion 202, as well as a pair of stabilization members 218, 220.In some examples, endplates 204 and 206 may be formed of PEEK or another suitable material.", "FIG.", "10 illustrates an exploded view of a vertebral insert 200, while FIG.", "11 shows a top view of the same device with a first endplate 204 removed.", "As shown in both views, a translation member 208 may include at least three expansion portions 222, 224, and 226, which may be connected via bridge portions 227.The expansion portions 222, 224, and 226 each may have angled surfaces that are configured to engage grooved portions of the first and second endplates 204 and 206.In some examples, the angled surfaces may be of similar angles, while in other examples, the angled surfaces may be of different angles.", "In at least some examples, providing at least three expansion portions 222, 224 and 226 may allow for an even expansion along a majority of the length of the body portion 202 of the vertebral insert 200.The translation member 208 may be received in the central opening of the body portion 202.The body portion 202 may include a first end 228 and a second end 230.In some examples, the first end 228 may include one or more apertures 232, 234 as shown in FIGS.", "10 and 11.These apertures 232, 234 may receive one or more stabilization members 218, 220.In some examples, the stabilization members 218, 220 each may include a first substantially smooth portion 236, 238, respectively, and a second threaded portion 240, 242, respectively.", "The stabilization members 218, 220 may be inserted through the apertures 232, 234 of the body portion 202, with the threaded portions 240, 242 serving as the leading end that enters the apertures.", "After passing through the apertures 232, 234 of the body portion 202, the stabilization members 218, 220 may come into contact with a side of the translation member 208.In some examples, the threaded portions 240, 242 of the stabilization members 218, 220 may be threaded into mateable threaded surfaces of the translation member 208.In some examples, by using a pair of stabilization members 218, 220 as shown in FIGS.", "10 and 11 on a first end of the body portion 202, rocking of the body portion 202 during expansion and contraction of the device 10 may be prevented.", "While the illustrated example in FIGS.", "10 and 11 show a pair of stabilization members 218, 220, in other examples, a single stabilization member or more than two stabilization members can be used to assist in preventing rocking of the body portion 202.In addition, while the stabilization members 218, 220 are illustrated as having a substantially cylindrical surface section, in other examples, the stabilization members 218, 220 can include other shapes and geometries.", "For example, in other examples, the stabilization members 218, 220 can have a surface that includes at least one edge or corner.", "As shown in FIGS.", "10 and 11, the body portion 202 also may include interference nut 216 that is positioned within a rear section of the body portion 202.In some examples, the interference nut 216 may be separate and removable from the body portion 202, while in other examples, the interference nut 216 may not be removable from the body portion 202.In some examples, the interference nut 216 may include a square nut that is operably connected to a rear section of the body portion 202.The interference nut 216 can be mateably connected to a rear of the body portion 202, for example, via a dove-tail type cut that encapsulates the interference nut 216.The interference nut 216 can be advantageously formed of a biocompatible material.", "In some examples, the interference nut 216 may be formed of PEEK.", "The interference nut 216 can include a hole (not shown) that is capable of receiving the actuation member 210 therethrough.", "The actuation member 210, which can comprise a threaded set screw, may pass through the interference nut 216 and into contact with the translation member 208, as best shown in FIG.", "11.The interference nut 216 may serve to add drag to the actuation member 210 as it passes therethrough, thereby establishing an interference fit.", "By providing an interference fit, the risk of the actuation member 210 being loosened prior to or during use may be minimized.", "A vertebral insert 300 is shown in FIG.", "12 that may be substantially similar to vertebral insert 200 except that a body portion 302 may be utilized instead of body portion 202.Vertebral insert 300 may include first and second endplates 304 and 306 that may include one or more features of first and second endplates 204 and 206 of vertebral insert 200.Body portion 302 may be substantially similar to body portion 202 except that an elongate member 308 may extend from a longitudinal side surface 310 of body portion 302.Elongate member 308 may generally have a T-shaped cross section that extends along a portion of longitudinal side surface 310, although other suitable configurations are also contemplated.", "A stabilization aperture 312 may be disposed at a middle portion of elongate member 308.Stabilization aperture 312 may be configured to receive a threaded portion of a stabilization member (not shown) to couple body portion 302 to a translation member (not shown, but similar to translation member 208 described with reference to FIG.", "11).", "Thus, stabilization aperture 312, in at least some examples, may help to provide rotational stability to the translation member relative to the body portion 302 prior to or during use of the vertebral insert 300.Once vertebral insert 300 is installed between vertebral bodies as shown in FIGS.", "13 and 14, the superior-inferior height (e.g., the distance between endplates 304 and 306) may be increased.", "When vertebral insert 300 is moved to the expanded height, a lateral spacer 340 also may be inserted between vertebral bodies 2 and 4.In other examples, lateral spacer 340 may be inserted into the intervertebral space and coupled to vertebral insert 300 before the height of vertebral insert 300 is increased.", "Lateral spacer 340 may be configured to mate with vertebral insert 300.Lateral spacer 340 may extend from a first, trailing end 342 toward a second, leading end 344.Lateral spacer 340 may include a groove or channel 346 configured to mate with elongate member 308 of body portion 302.Channel 346 may be at least partially defined by one or more rails 348.The ends of channel 346 and rails 348 may terminate at a gap 369 which extends in the superior-inferior directions.", "Gap 369 may facilitate machining of lateral spacer 340 and may increase the amount of graft that can be applied to vertebral insert 300.In some examples, any additional number of gaps 369 may be included along the length of channel 346 and rails 348.That is, channel 346 and rails 348 may include a series of interrupted channels and rails that through which elongate member 308 of body portion 302 may pass through.", "In some examples, elongate member 308, channel 346, and rails 348 may form a tongue and groove joint, although other suitable connections are also contemplated.", "Gap 369 may be configured to separate channel 346 and rails 348 from a stop surface 364 that is configured to abut elongate member 308 of vertebral insert 300.In some examples, lateral spacer 340 may define a cavity 350 that may be similar to cavities 150 and 167 described above.", "Cavity 350 may be packed with bone graft or bone-growth inducing substances in a substantially similar manner as cavities 150 and 167.In some examples, cavity 350 may be at least partially defined by an arc portion 352 that may approximate the anterior curvature of a vertebral body.", "However, any or all portions of vertebral insert 300 can be formed in any other suitable configuration depending upon the geometry of the vertebral bodies between which it is to be inserted.", "In one example, body portion 302 may be positioned at the posterior end between two vertebral bodies.", "However, it is also contemplated that body portion 302 also may be positioned toward the anterior end.", "Then, lateral spacer 340 may be inserted at the anterior end (if body portion 302 is positioned at the posterior end) or the posterior end (if body portion 302 is positioned at the anterior end).", "It is also contemplated that body portion 302 may include an additional elongate member 308 at a longitudinal side surface opposite of longitudinal side surface 310 to allow body portion 302 to mate with two different lateral spacers.", "For example, in some examples, body portion 302 may accommodate an additional lateral spacer, e.g., as shown in FIGS.", "1-9.FIG.", "15 shows a top view of vertebral insert 300 and lateral spacer 340 installed on a vertebral body.", "FIG.", "16 is a side view of vertebral insert 300 and lateral spacer 340 installed between vertebral bodies.", "In some examples, one or more of vertebral insert 300 and lateral spacer 340 may be configured to provide lordosis correction.", "In some examples, vertebral insert 300 and lateral spacer 340 together may form a continuous angled and ramped surface.", "In other examples, vertebral insert 300 and lateral spacer 340 each may be ramped at different angles to provide differing degrees of lordosis correction based on the specific geometries of vertebral bodies between which they are inserted.", "In some examples, vertebral insert 300 and lateral spacer 340 may be secured between vertebral bodies 2 and 4 via a minimally invasive plate system that is configured to provide stabilization through a lateral approach.", "The plate system may include brackets, bone screws, blocking screws, and other suitable elements to maintain vertebral insert 300 and lateral spacer 340 between vertebral bodies 2 and 4.In some examples, vertebral insert 300 and lateral spacer 340 may be delivered by a minimally invasive (MIS) lateral lumbar interbody fusion (LLIF) approach.", "Vertebral insert 300 and lateral spacer 340 may be configured to provide increased surface area over conventional vertebral inserts.", "Vertebral insert 300 may provide improved spacer fit by allowing for anterior and/or posterior spacer selection.", "In some examples, vertebral insert 300 and lateral spacer 340 may provide increased total surface area contact with vertebral bodies while also engaging harder bone around the apophyseal ring.", "In still further examples, vertebral insert 300 and lateral spacer 340 may provide for increased amount of bone graft or bone-growth inducing substances to be utilized over conventional devices.", "In some examples, vertebral insert 300 may provide for more even weight load distribution, reduce cage subsidence, provide a large fusion bed graft area, and/or a higher degree of height and lordotic correction by having separate posterior and/or anterior spacers.", "Another example of a vertebral insert 400 is shown in FIGS.", "17-20.Vertebral insert 400 may be reciprocally movable between a first, collapsed configuration (shown in FIG.", "17) and a second, expanded configuration (shown in FIG.", "18).", "In some examples, vertebral insert 400 may be a collapsible and expandable ring-shaped member that defines a cavity 460.Cavity 460 may be packed with bone graft in a substantially similar manner as set forth above.", "Vertebral insert 400 may extend from a first, trailing end 402 toward a second, leading end 404.Vertebral insert 400 may include a first linkage 406, a second linkage 408, a third linkage 410, and a fourth linkage 412.First linkage 406 may include a hollow elongate portion 414 and a flange portion 416.Hollow elongate portion 414 may be generally cylindrical or have another suitable shape.", "Flange portion 416 may extend radially outward from hollow elongate portion 414 at a middle longitudinal section or other suitable longitudinal section.", "An elongate member 418 (e.g., a rod) may extend from flange portion 416 to couple first linkage 406 with second linkage 408.Elongate member 418 also may prevent the rotation of first linkage 406 relative to second linkage 408.In an alternative example, hollow elongate portion 414 may be formed in a shape configured to prevent the relative rotation of the first and second linkages 406 and 408 (such as, e.g., square, rectangular, star, or the like).", "Flange portion 416 also may include features 417 to couple first linkage 406 to third linkage 410.Features 417 may include a pair of flanges configured to form a joint with an extension of third linkage 410 (e.g., a bridle joint, a mortise and tenon joint, or another suitable joint or connection).", "In some examples, the pair of flanges may have apertures or pin holes that are aligned with one another to receive a securing mechanism such as, e.g., a pin that extends through each of the pair of flanges and the extension of third linkage 410, so as to rotatably couple first linkage 406 with third linkage 410.Second linkage 408 may include an end portion 420 having a recess 422 (referring to FIG.", "18) disposed therethrough that is configured to slidably receive hollow elongate portion 414 of first linkage 406.A longitudinal portion 424 may extend from end portion 420 toward a distraction end 426.End portion 420 may be disposed at an angle (e.g., 90 degrees) relative to longitudinal portion 424.A recess 427 (shown in dotted lines in FIG.", "17) may extend through end portion 420 and at least partially through longitudinal portion 424 to receive elongate member 418 therein.", "Distraction end 426 may be disposed at second, leading end 404 of vertebral insert 400 and may be wedged, bladed, or have another suitable shape to facilitate the distraction of a pair of vertebral bodies upon insertion of vertebral insert 400.That is to say, distraction end 426 may include a tapered configuration.", "In some examples, because of the relationship of recess 422 and elongate portion 414, and of elongate member 418 and recess 427, first linkage 406 and second linkage 408 may be configured to slidably and longitudinally move with respect to one another.", "Third linkage 410 may be a generally elbow shaped member that may be coupled to first linkage 406 (via features 417 described above) at one end, and coupled to fourth linkage 412 at a second end.", "Third linkage 410 may be formed from two arms 428 that converge at a bend 430 joining the two arms 428.In some examples, the two arms 428 may form an oblique angle with respect to one another.", "The second end of third linkage 410 may include mating features 432 that may be substantially similar to mating features 417 of first linkage 406.The mating features 432 may be configured to receive an extension of fourth linkage 412 to form a joint such as, e.g., a bridle type joint, a mortise and tenon type joint, or another suitable joint or connection.", "Fourth linkage 412 also may be a generally elbow shaped member that is coupled to third linkage 410 at one end, and coupled to second linkage 408 at another end.", "Each end of fourth linkage 412 may include any suitable connector, extension, flange, coupling, or the like to mate with a corresponding feature on third linkage 410 and/or second linkage 408.Third and fourth linkages 410 and 412 together, when vertebral insert 400 is in the expanded configuration, may form an arc portion that generally approximates the anterior curvature of a vertebral body.", "In the collapsed configuration of vertebral insert 400, third and fourth linkages 410 and 412 may be buckled laterally inward.", "In the expanded configuration of vertebral insert 400, third and fourth linkages 410 and 412 may bow laterally outward.", "In some examples, the superior-inferior height of vertebral insert 400 may remain unchanged in both the collapsed and expanded configuration of vertebral insert 400.The various linkages described with reference to FIG.", "17 may be formed of any suitable biocompatible material, such as, e.g., titanium, PEEK, or the like.", "In some examples, the linkages may be treated with a titanium and/or hydroxyapatite plasma spray coating to encourage bony on-growth, improving the strength and stability of the connection between the respective component and the underlying bone (e.g., a vertebral body).", "Vertebral insert 400 may be inserted between vertebral bodies while in a collapsed configuration (shown in FIG.", "17) while attached to a positioning tool 490, to another suitable tool, or unattached to a tool.", "A holding member 492 may be disposed at a distal end of positioning tool 490 and may extend through hollow elongate portion 414 and end portion 420 to couple to a recess or bore (not shown) disposed within distraction end 426 of second linkage 408.In one example, holding member 492 may be a threaded screw extending from a proximal portion 484.Holding member 492 may be fastened to distraction end 426 in some examples.", "An elongate drive member 496 may be slidable relative to holding member 492.In some embodiments, elongate drive member 496 may be hollow.", "Once holding member 492 is fastened to distraction end 426 of second linkage 408, driving member 496 then may be coupled to a first end of first linkage 406 as shown in FIG.", "17 (via, e.g., threads or the like).", "Drive member 496 may be advanced distally to push first linkage 406 from first end 402 toward second end 404 of vertebral insert 400, causing vertebral insert 400 to move from the first, collapsed configuration to the second, expanded configuration (FIG.", "18).", "Once vertebral insert 400 is in the expanded configuration, a suitable locking mechanism such as, e.g., a tang, blocking screw, latch, or other suitable locking mechanism may stabilize vertebral insert 400 into the expanded configuration.", "Once locked into the expanded configuration, holding member 492 and drive member 496 may be disconnected and withdrawn from the patient.", "In some examples, a distal portion of holding member 492 may be left within vertebral insert 400 and only proximal portion 494 and drive member 496 may be withdrawn.", "Thus, in some examples, holding member 492 may be configured to lock vertebral insert into the expanded configuration, via, e.g., a rotatable locking flange (not shown) disposed at a proximal end of holding member 492.Subsequently, bone graft may be packed into cavity 460 via, e.g., a lumen of elongate drive member 496.A spacer assembly 500 is shown in FIGS.", "21-36.Spacer assembly 500 may include a plate assembly 600, one or more fastening members 502, a bracket 800, and a spacer 802.As best seen in FIGS.", "22 and 23, plate assembly 600 may extend from a first end 602 toward a second 604.In some embodiments, plate assembly 600 may include a plurality of plates moveable relative to each other, as described below.", "For example, a first plate 606 may extend from first end 602 toward second end 604, while a second plate 608 may extend from second end 604 toward first end 602.In embodiments having a single plate (not shown), however, a cavity extending through plate assembly 600 may be selectively adjustable.", "With specific reference to FIGS.", "22-24, first plate 606 may include a substantially rectangular portion 610 and a substantially semi-circular portion 612 extending from rectangular portion 610.As shown in FIG.", "22, first plate 606 may further include a throughbore 614.Throughbore 614 may be disposed completely in semi-circular portion 612, completely in rectangular portion 610, or partially in semi-circular portion 612 and partially in rectangular portion 610, as shown.", "On a first side 616 of first plate 606, throughbore 614 may include an opening 618.Opening 618 may be surrounded by a raised lip 620 extending around the periphery of opening 618.Raised lip 620 may include any suitable configuration.", "In one embodiment, raised lip 620 may include a substantially square cross-sectional configuration.", "Those of ordinary skill in the art, however, will recognize that raised lip 620 may include any suitable cross-sectional configuration.", "Though the depicted embodiment shows raised lip 620 as continuously extending around opening 618, raised lip 620 may include one or more breaks, such that it does not extend continuously around opening 618.In some embodiments, opening 618 may further include a radially inward lip 622 extending away from a wall defining opening 618.With continued reference to FIG.", "22, first side 616 may further include a stepped portion 624.Stepped portion 624 may be spaced from a surface 626 by a vertical wall 628 (shown in FIG.", "24).", "Stepped portion 624 may include any suitable configuration.", "In one embodiment, stepped portion 624 may include a substantially constant cross-sectional dimension.", "However, in some embodiments, stepped portion 624 may include a tapered cross-sectional configuration.", "Stepped portion 624 may have a smaller cross-sectional dimension (e.g., thickness) relative to a remainder of first plate 606.Stepped portion 624 may include a surface on first side 616 having one or more geometric configurations 630 to increase friction.", "For example, geometric configurations 630 may include one or more teeth, ridges, divots, cavities, or other similar structures.", "Further, stepped portion 624 may define an elongated channel 632 extending through stepped portion 624.Although a single elongate channel 632 is depicted, stepped portion 624 may include a plurality of channels or cavities.", "Elongate channel 632 may include any suitable configuration.", "As will be described in further detail below, elongate channel 632 may be configured to receive a portion of a locking member 634.With reference now to FIG.", "23, first plate 606 may include a second side 636 disposed opposite to the first side 616.Second side 636 may be substantially planar.", "In some embodiments, an opening 638 of throughbore 614 may be surrounded by a raised atraumatic lip 640.Lip 640 may include any suitable configuration, including, but not limited to, a curved outer periphery.", "A portion of lip 640 may include a cutout 642 corresponding to an end of elongate channel 632.As can also be seen in FIG.", "23, elongate channel 632 may extend through first plate 606 to an opening 644 on second side 636.Opening 644 may include counterbore features extending around a periphery of opening 644 to receive an end of a locking member 634.With continued reference to FIGS.", "22-24, second plate 608 may include a substantially rectangular portion 650 and a substantially semi-circular portion 652 extending from rectangular portion 650.Second plate 608 may further include a throughbore 654.Throughbore 654 may be disposed completely in semi-circular portion 652, completely in rectangular portion 650, or partially in semi-circular portion 2215 and partially in rectangular portion 650, as shown.", "On a first side 656 of second plate 608, throughbore 654 may include an opening 658.Opening 658 may be surrounded by a raised lip 660 extending around the periphery of opening 658.Raised lip 660 may include any of the features described above with respect to raised lip 620.In some embodiments, opening 658 may further include a radially inward lip 662 extending away from a wall defining opening 658.In the embodiment shown in FIGS.", "22-24, rectangular portion 650 may define a cavity 664 (e.g., a rectangular cavity configured to receive a vertebral spacer 802 shown in FIGS.", "25-27).", "Locking member 634 may extend through a recess disposed in an end wall 666 that at least partially defines cavity 664.The end wall 636 may include a protrusion 668 that extends into cavity 664.The protrusion 668 may accommodate various features (e.g., locking features) associated with locking member 634.In some examples, locking member 634 may include a head portion 670 that abuts the first side 656 of second plate 608.Cavity 664 also may be at least partially defined by a side wall 672 and side wall 674.In some examples, side walls 672 and 674 may be substantially parallel to one another and orthogonal to end wall 636.A locking member 676 may extend through a recess disposed in side wall 672 while a locking member 678 may extend through a recess disposed in side wall 674.Locking members 676 and 678 may include one or more locking features described with reference to locking member 634.Side wall 672 may include a protrusion 680 and side wall 674 may include a protrusion 682.Protrusions 680 and 682 may accommodate locking features of locking members 676 and 678, respectively, and may be configured to extend away from cavity 664 in opposite directions.", "With reference now to FIG.", "23, second plate 608 may include a second side 686 disposed opposite to the first side 656.Second side 686 may be substantially planar.", "In some embodiments, an opening 688 of throughbore 654 may be surrounded by a raised atraumatic lip 690.Lip 690 may include may include one or more features described above with reference to lip 640.Second side 686 may further include a stepped portion 694 disposed on end wall 674.Stepped portion 694 may be spaced from a surface 696 by a vertical wall 698 (shown in FIG.", "23).", "Stepped portion 694 may include any suitable configuration including those described with reference to stepped portion 624 of first plate 606, and may include geometric features 700 that may be substantially similar to geometric features 630.Second side 686 also may include a stepped portion 704 that is disposed along end wall 672.Stepped portion 704 may be spaced from surface 696 by a vertical wall 708 and may include geometric features 710 that are substantially similar to geometric features 630 and 700.The stepped portions of second plate 608 (e.g., stepped portions 694, 704 and a stepped portion of end wall 666) may have a smaller cross-sectional dimension (e.g., thickness) than a remainder of second plate 608.Side walls 672 and 674 also may include counterbore features 712 and 714 that may be configured to receive portions of locking members 676 and 678, respectively.", "As described above, first and second plates 606 and 608 may be movable relative to one another when coupled via locking member 634.In some examples, stepped portion 624 of first plate 606 may be slidably coupled to stepped portions 694 and 704 of second plate 608.When coupled to one another, first and second plates 606 and 608 may form an adjustable joint or other suitable connection.", "In one example, first and second plates 606 and 608 may form a half lap splice joint, although other suitable connections are also contemplated.", "The relative movement of first plate 606 and 608 with respect to one another may define an effective opening of cavity 664.That is, cavity 664 may be movable between a first, fully-open configuration (shown in FIG.", "24), and a second, partially-open configuration (shown in FIG.", "22).", "In the second, partially-open configuration, stepped portion 624 of first plate 606 may extend over and cover cavity 664, reducing the effective opening size of cavity 664.That is, stepped portion 624 may extend over cavity 664 to reduce the size of a vertebral spacer that can be received by cavity 664.It is also contemplated that cavity 664 may include any number of intermediate configurations between the first, fully-open configuration and the second, partially-open configuration.", "Locking member 634 may be reciprocally movable between a plurality of configurations and may be configured to couple first and second plates 606 and 608 to one another.", "In a first configuration, locking member 634 may couple first plate 606 to second plate 608 and may permit the relative movement of first and second plates 606 and 608 with respect to one another.", "In a second configuration, locking member 634 may fix the orientation of first plate 606 with respect to second plate 608 by any suitable mechanism such as, e.g., tightening a threaded engagement, moving a locking flange or other mechanism into a locking position, or the like.", "FIGS.", "25-27 depict exploded and assembled views of a bracket 800 and a spacer 802.Bracket 800 may be a bracket configured to couple to both spacer 802 and plate assembly 600 described above.", "Bracket 800 may include a generally rectangular elongate surface 804 having a first elongate cavity 806 and a second elongate cavity 810 extending through elongate surface 804.The lengths of elongate cavities 806 and 810 may be generally parallel to one another, and each may be generally perpendicular to the length of elongate surface 804, although other suitable configurations are also contemplated.", "Bracket 800 also may include a protrusion 812 (shown only in FIG.", "26) that extends away from elongate surface 804.A bore 814 may extend through elongate surface 804 and protrusion 812 to receive a fastener (e.g., a threaded screw or the like).", "In some examples, bracket 800 may be curved at its lateral edges.", "Spacer 802 may be any suitable intervertebral spacer.", "In the example shown in FIGS.", "25-27, spacer 802 may be a generally rectangular spacer defining a cavity 816.Cavity 816 may be packed with bone graft or bone-growth inducing materials.", "A lateral end surface of spacer 802 may define a recess 818 and a bore 820 configured to receive protrusion 812 and fastener 822 respectively.", "Recess 818 and bore 820 of spacer 802 may be complimentary to protrusion 812 and fastener 822 so as to limit movement of bracket 800 and spacer 802 with respect to one another.", "Spacer 802 may be any suitable intervertebral spacer, and may include one or more of inferior surfaces, superior surfaces, biconvex surfaces, among others.", "In some examples, the surfaces of spacer 802 or any other bone contacting surface described in the present disclosure may include one or more of teeth, ridges, friction increasing elements, keels, or gripping or purchasing projections.", "FIGS.", "28-36 depict an exemplary method of installing spacer assembly 500 within a patient.", "Initially, plate assembly 600 may be brought in proximity with two vertebral bodies 2 and 4 (FIG.", "28).", "In one example, during initial installation, first and second plates 606 and 608 may be in the second, partially-open configuration where cavity 628 has its smallest effective opening.", "As shown in FIG.", "29, bore 654 may be aligned with vertebral body 4 while, bore 614 may be aligned with vertebral body 2.First and second plates 606 and 608 may be moved toward the fully-opened configuration depending upon the desired distance between vertebral bodies 2 and 4 to optimize fit.", "It is contemplated that in some examples, plate assembly 600 may be in an intermediate configuration between the first and second configurations at this stage such that cavity 664 is at an intermediate opening size.", "A fastening member 502 may then be used to secure one of first or second plates 606 and 608 to a respective vertebral body (FIG.", "30), and another fastening member 502 may be used to secure another fastener 502 to secure the other of first and second plates 606 and 608 to a respective vertebral body (FIG.", "31).", "Once first and second plates 606 and 608 are secured to vertebral bodies 2 and 4, an operator may distract vertebral bodies 2 and 4 from one another via first and second plates 606 and 608.That is, an operator may move first and second plates 606 and 608 away from one another to move vertebral bodies 2 and 4 away from one another.", "Once vertebral bodies 2 and 4 have been moved away from one another (e.g., distracted) by a sufficient distance, an operator may lock the distracted position by moving locking member 634 from an unlocked configuration to a locked configuration, thereby locking the positions of first and second plates 606 and 608 and also vertebral bodies 2 and 4.It is further contemplated that the positions of first and second plates 606 and 608 may be fixed with respect to one another by any other suitable mechanism.", "Once vertebral bodies 2 and 4 are distracted and locked into position, spacer 802 may be inserted through cavity 664 (FIGS.", "34 and 35).", "As spacer 802 is moved between the vertebral bodies, bracket 800 may abut second plate 608 of plate assembly 600.Further, locking elements 676 and 678 may be positioned to extend through elongate cavities 806 and 810.The locking elements 676 and 678 may then be moved from an insertion configuration to a locking configuration, thereby securing spacer 802 between vertebral bodies 2 and 4.Spacer assembly 500 may provide one or more of the following advantages, including: an increased tactile feel while distracting, an increased range of distraction height, increased bone graft size and placement, improved radiolucent viewing, decreased stress on endplates and reduced chance of subsidence, and the potential elimination of the need for posterior fixation.", "Any aspect set forth in any example may be used with any other example set forth herein.", "Every device and apparatus set forth herein may be used in a suitable medical procedure, such as, e.g., a vertebral disc replacement procedure, and may be advanced through any suitable body lumen and body cavity.", "It will be apparent to those skilled in the art that various modifications and variations can be made in the disclosed systems and processes without departing from the scope of the disclosure.", "Other examples of the disclosure will be apparent to those skilled in the art from consideration of the specification and practice of the embodiments disclosed herein.", "It is intended that the specification and examples be considered as exemplary only." ] ]
Patent_15874253
[ [ "SYSTEMS AND METHODS FOR WIRELESS AUTHORIZATION AT A VENDING MACHINE", "Some embodiments are associated with wireless payment or account verification or authorization for purchases made from a vending machine via a customer's mobile device." ], [ "1.A vending machine configured to wirelessly validate payment of a customer, comprising: a processing device; a wireless receiver device in communication with the processing device; a network device in communication with the processing device; and a non-transitory memory device storing instructions that when executed by the processing device, result in: receiving, by the vending machine and from a customer, an indication of a product for which a unit is desired to be purchased by the customer from the vending machine; receiving, by the wireless receiver device of the vending machine and from a portable electronic device of the customer, a wireless signal indicative of an account identifier of the customer; transmitting, by the network device of the vending machine and in response to the receiving of the wireless signal, an indication of the account identifier of the customer to a remote network device; receiving, by the network device of the vending machine in response to the transmitting and from the remote network device, an indication that a payment, by the customer and for the desired unit of the product, is validated; and providing, by the vending machine and in response to the indication of the payment validation, the unit of the product to the customer.", "2.The vending machine of claim 1, wherein the instructions, when executed by the processing device, further result in: outputting, by the vending machine, an electronic signal that causes the wireless signal of the portable electronic device to be output by the portable electronic device.", "3.The vending machine of claim 1, wherein the receiving of the indication of the product for which the unit is desired to be purchased by the customer from the vending machine is conducted by: receiving, by the wireless receiver device of the vending machine and from the portable electronic device of the customer, a wireless indication of the desired unit of the product.", "4.The vending machine of claim 1, wherein the receiving of the indication of the product for which the unit is desired to be purchased by the customer from the vending machine is conducted via a customer interaction with an input device physically coupled to the vending machine.", "5.The vending machine of claim 1, wherein the wireless signal indicative of the account identifier of the customer comprises an indication of a credit card account number.", "6.The vending machine of claim 1, wherein the wireless signal indicative of the account identifier of the customer comprises an indication of an identifier of the portable electronic device of the customer.", "7.The vending machine of claim 1, wherein the remote network device comprises a credit card processing server.", "8.The vending machine of claim 1, wherein the vending machine further comprises a dispensing device in communication with the processing device and wherein the providing of the unit of the product to the customer comprises: dispensing, by the dispensing device of the vending machine, the unit of the product to the customer.", "9.The vending machine of claim 1, wherein the portable electronic device comprises a cellular telephone device.", "10.A vending machine configured to wirelessly validate an account of a customer, comprising: a processing device; a wireless receiver device in communication with the processing device; a network device in communication with the processing device; and a non-transitory memory device storing instructions that when executed by the processing device, result in: receiving, by the wireless receiver device of the vending machine and from a portable electronic device of a customer, a wireless signal indicative of an account identifier of the customer; establishing, by the network device of the vending machine and in response to the receiving of the wireless signal, a communication session with a remote network device; receiving, by the network device of the vending machine and from the remote network device, an indication that the account identifier of the customer is validated; receiving, by the vending machine and from the customer, an indication of a product for which a unit is desired to be purchased by the customer from the vending machine; and providing, by the vending machine and in response to the indication of the account identifier validation and the indication of the desired product, the unit of the product to the customer.", "11.The vending machine of claim 10, wherein the instructions, when executed by the processing device, further result in: outputting, by the vending machine, an electronic signal that causes the wireless signal of the portable electronic device to be output by the portable electronic device.", "12.The vending machine of claim 10, wherein the receiving of the indication of the product for which the unit is desired to be purchased by the customer from the vending machine is conducted by: receiving, by the wireless receiver device of the vending machine and from the portable electronic device of the customer, a wireless indication of the desired unit of the product.", "13.The vending machine of claim 10, wherein the receiving of the indication of the product for which the unit is desired to be purchased by the customer from the vending machine is conducted via a customer interaction with an input device physically coupled to the vending machine.", "14.The vending machine of claim 10, wherein the wireless signal indicative of the account identifier comprises an indication of a credit card account number.", "15.The vending machine of claim 10, wherein the wireless signal indicative of the account identifier comprises an indication of an identifier of the portable electronic device of the customer.", "16.The vending machine of claim 10, wherein the remote network device comprises a credit card processing server.", "17.The vending machine of claim 10, wherein the vending machine further comprises a dispensing device in communication with the processing device and wherein the providing of the unit of the product to the customer comprises: dispensing, by the dispensing device of the vending machine, the unit of the product to the customer.", "18.The vending machine of claim 10, wherein the portable electronic device comprises a cellular telephone device." ], [ "<SOH> BACKGROUND <EOH>Significant resources are often spent creating wired and Wireless Access Points (WAPs) to the Internet for the purpose of giving more and more electronic devices Internet connectivity.", "Notable in this endeavor is the emergence of “Wi-Fi”, wireless broadband connection to the Internet.", "Companies ranging from start-ups (such as Boingo® and Cometa Networks™) to large telecommunications companies (such as Sprint™ and AT&T™) are developing WAPs to the Internet called “hot spots” (or “Wi-Fi” hot spots).", "A hotspot typically consists of computer hardware and software capable of (1) wirelessly communicating with a user's personal mobile device (laptop computer, Personal Digital Assistant (PDA), cell phone, etc.", "), and (2) connecting to the Internet (or other communications network).", "The wireless connection between the hotspot and the personal mobile devices within the vicinity is typically established via a wireless router, such as a wireless router operating pursuant to the Fast Ethernet LAN transmission standard 802.3-2002® published by the Institute of Electrical and Electronics Engineers (IEEE) and/or the Wireless LAN transmission standard 802.11B/G-1999/2003® published by the IEEE.", "The connection to the Internet or other communications network is generally wired (e.g., via Digital Subscriber Line (DSL), cable modem, T1).", "Access to the Internet via the hotspot router generally requires a valid user account within the provider's network.", "Users pay subscription fees, either monthly, or as service is used.", "For example, unlimited access on the Boingo® network is currently priced between twenty-one dollars and ninety-five cents ($21.95) to thirty-nine dollars and ninety-five cents ($39.95) per month, or one can buy a two-day (2-day) subscription for seven dollars and ninety-five cents ($7.95).", "I-mobile® charges nineteen dollars and ninety-five cents ($19.95) per month.", "A goal of companies who provide or facilitate WAPs, or “Wi-Fi hotspots,” is to create national wireless coverage for users by patching together a network of local access points from various providers (cable, DSL, etc).", "So far, their strategy is to convince operators of hotels, coffee shops, restaurants, and bookstores to become hot spot hosts as a value add to their customers.", "Brand name locations hosting hot spots include Jet Blue® terminals, Starbuck's®, Tully's Coffee®, and even McDonald's®.", "However, a need exists for apparatus, systems, and methods that extend the possible venues that can provide Wi-Fi service and/or that can facilitate more easy, widespread, and/or ad-hoc access." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>An understanding of embodiments described herein and many of the attendant advantages thereof may be readily obtained by reference to the following detailed description when considered with the accompanying drawings, wherein: FIG.", "1 is a block diagram of a system according to some embodiments; FIG.", "2 is a block diagram of a vending machine according to some embodiments; FIG.", "3 is a diagram illustrating an example of the external appearance of a vending machine according to some embodiments; FIG.", "4 is a flow diagram of a method according to some embodiments; and FIG.", "5 is a flow diagram of a method according to some embodiments.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS The present application claims benefit and priority under 35 U.S.C.", "§ 120 to, and is a continuation of, U.S. application Ser.", "No.", "13/365,962 filed Feb. 3, 2012 and titled “SYSTEMS AND METHODS FOR PROVIDING NETWORK ACCESS” which itself claims benefit and priority to and is a continuation of U.S. application Ser.", "No.", "11/376,488 filed Mar.", "15, 2006 and titled “SYSTEMS AND METHODS FOR PROVIDING NETWORK ACCESS”, which issued as U.S. Pat.", "No.", "8,774,963 on Jul.", "8, 2014, and which itself claims benefit and priority to U.S.", "Provisional Patent Application Ser.", "No.", "60/662,139, titled “WI-FI VENDING MACHINE” and filed on Mar.", "15, 2005, the entirety of each such previous application being hereby incorporated by reference herein.", "The present application is also related to U.S. patent application Ser.", "No.", "14/317,789 titled “SYSTEMS AND METHODS FOR PROVIDING NETWORK ACCESS” filed Jun.", "27, 2014, now abandoned.", "BACKGROUND Significant resources are often spent creating wired and Wireless Access Points (WAPs) to the Internet for the purpose of giving more and more electronic devices Internet connectivity.", "Notable in this endeavor is the emergence of “Wi-Fi”, wireless broadband connection to the Internet.", "Companies ranging from start-ups (such as Boingo® and Cometa Networks™) to large telecommunications companies (such as Sprint™ and AT&T™) are developing WAPs to the Internet called “hot spots” (or “Wi-Fi” hot spots).", "A hotspot typically consists of computer hardware and software capable of (1) wirelessly communicating with a user's personal mobile device (laptop computer, Personal Digital Assistant (PDA), cell phone, etc.", "), and (2) connecting to the Internet (or other communications network).", "The wireless connection between the hotspot and the personal mobile devices within the vicinity is typically established via a wireless router, such as a wireless router operating pursuant to the Fast Ethernet LAN transmission standard 802.3-2002® published by the Institute of Electrical and Electronics Engineers (IEEE) and/or the Wireless LAN transmission standard 802.11B/G-1999/2003® published by the IEEE.", "The connection to the Internet or other communications network is generally wired (e.g., via Digital Subscriber Line (DSL), cable modem, T1).", "Access to the Internet via the hotspot router generally requires a valid user account within the provider's network.", "Users pay subscription fees, either monthly, or as service is used.", "For example, unlimited access on the Boingo® network is currently priced between twenty-one dollars and ninety-five cents ($21.95) to thirty-nine dollars and ninety-five cents ($39.95) per month, or one can buy a two-day (2-day) subscription for seven dollars and ninety-five cents ($7.95).", "I-mobile® charges nineteen dollars and ninety-five cents ($19.95) per month.", "A goal of companies who provide or facilitate WAPs, or “Wi-Fi hotspots,” is to create national wireless coverage for users by patching together a network of local access points from various providers (cable, DSL, etc).", "So far, their strategy is to convince operators of hotels, coffee shops, restaurants, and bookstores to become hot spot hosts as a value add to their customers.", "Brand name locations hosting hot spots include Jet Blue® terminals, Starbuck's®, Tully's Coffee®, and even McDonald's®.", "However, a need exists for apparatus, systems, and methods that extend the possible venues that can provide Wi-Fi service and/or that can facilitate more easy, widespread, and/or ad-hoc access.", "BRIEF DESCRIPTION OF THE DRAWINGS An understanding of embodiments described herein and many of the attendant advantages thereof may be readily obtained by reference to the following detailed description when considered with the accompanying drawings, wherein: FIG.", "1 is a block diagram of a system according to some embodiments; FIG.", "2 is a block diagram of a vending machine according to some embodiments; FIG.", "3 is a diagram illustrating an example of the external appearance of a vending machine according to some embodiments; FIG.", "4 is a flow diagram of a method according to some embodiments; and FIG.", "5 is a flow diagram of a method according to some embodiments.", "DETAILED DESCRIPTION I.", "Introduction Applicants have recognized that, in some situations, it may be advantageous to provide a vending machine (and/or other device, such as a kiosk) configured to host wireless local area networks (e.g., via WAPs), thus permitting customers to access the Internet and/or other public communication networks through personal mobile devices (hereinafter “customer devices”).", "More particularly, Applicants hereby disclose apparatus, systems, and methods for facilitating the sale and distribution of wireless access to a communications network through a vending machine (and/or other device) that may also be configured to dispense one or more physical products, such as snacks and drinks.", "In accordance with one or more embodiments, a vending machine may permit a customer, through a customer device such as a Personal Computer (PC), PDA, or cellular telephone, to access a communications network (e.g., PSTN, the Internet) after first establishing a preliminary communication link between the customer device and the vending machine.", "According to one or more embodiments, a vending machine may be configured to: (i) output a message to a customer, through a vending machine and/or customer device, prompting the customer to utilize a communication network; (ii) receive, from the customer, a request to initiate a communication session, the request comprising one or more of (a) a signal indicating an acceptance of an offer, (b) a signal indicating a product selection, (c) a tendered payment, (d) a payment identifier, (e) a customer identifier, and/or (f) a customer device identifier; (iii) establish a first communication link with a customer device; and/or (iv) establish a second communication link with at least one remote device (e.g., a server computer), thereby permitting the customer device to send data to and/or receive data from the at least one remote device (e.g., permitting Wi-Fi access to the Internet).", "In some embodiments, additional and/or alternative steps may include: (i) outputting an access code to a customer (e.g., via receipt printer; on sticker attached to a product; via email sent to a customer device); (ii) receiving an access code from a customer (e.g., via customer device); (iii) verifying/validating an access code (e.g., by confirming that access code received matches one previously issued); (iv) upon verifying/validating an access code, establishing the second communication link; (v) determining a price to charge a customer based on one or more of: (a) a customer's status (e.g., a customer's status as a prepaid unit account holder, such as is described in Applicants' co-pending U.S. Pat.", "App.", "Serial No.", "US2004/041561, the customer account descriptions and concepts of which are hereby incorporated by reference herein), (b) an amount of usage (e.g., ten (10) minutes of Wi-Fi access), (c) a product selected by the customer (e.g., Wi-Fi access is less expensive if a customer selects a higher margin snack product; Internet access is free if a customer selects a Coke® product); and/or (vi) dispensing a physical product (such as a snack, drink, music CD, DVD).", "In some embodiments, the vending machine may hold a “master” Wi-Fi account, and customers may purchase minutes of access time utilizing this account.", "Customers may tender payment to the vending machine, obtain an access code from the vending machine, and/or use that access code to gain access to the Wi-Fi network for a period of time through the vending machine.", "According to some embodiments, purchase of time may be made directly through the customer's wireless device itself (without requiring the customer to interact with the vending machine's interface).", "Simply by being within a certain physical proximity of the vending machine, for example, may allow the customer to sign-up for or access an existing account for minutes credited through the machine (e.g., utilizing Bluetooth® technology).", "Vending machines (and/or other devices) configured in accordance with the embodiments described herein may generally benefit consumers in that such machines may provide increased access to communications networks (e.g., Wi-Fi access to the Internet).", "Vending machines configured to host “hotspots” in accordance with some embodiments may provide, for example, hot spot service providers (e.g., Boingo®, Cometa™) with an opportunity to increase service, increase market penetration, and/or lower costs (and ultimately prices).", "Vending machines configured in accordance with some embodiments may benefit operators of vending machines as they provide more opportunities to serve customers through the ability to provide access to communications networks.", "Additionally, vending machines that provide access to communications networks may attract customers who otherwise may not have purchased traditionally vended physical goods (a snack or a drink).", "That is, the added functionality provided through network access may attract customers to the machine, making it more likely that they will purchase physical goods.", "Further still, vending machines configured in accordance with some embodiments may benefit operators of vending machines through the ability to offer new promotions, including package promotions, where access to communications networks are sold along with physical goods for a single price which is less than the sum of the individual retail prices of each component product.", "Moreover, vending machines according to some embodiments may attract new types of customers (e.g., customers who may generally wish to purchase wireless network access but not traditionally vended physical products such as food items).", "II.", "Terms and Definitions Throughout the description that follows and unless otherwise specified, the following terms may include and/or encompass the example meanings provided in this section.", "These terms and illustrative example meanings are provided to clarify the language selected to describe embodiments both in the specification and in the appended claims.", "Some embodiments described herein are associated with a “control system”.", "As used herein, the term “control system” may generally refer to any combination of hardware, software, firmware, and/or microcode that is operative to carry out and/or facilitate embodiments described herein.", "For example, a control system may comprise a processor performing instructions of a program to provide Wi-Fi access to customers.", "The control system may comprise, according to some embodiments, a single device and/or component or may comprise any practicable number of networked devices.", "Some embodiments described herein are associated with a “network device”.", "As used herein, the term “network device” may generally refer to any device that can communicate via a network.", "Examples of network devices include a PC, a workstation, a server, a printer, a scanner, a facsimile machine, a copier, a PDA, a storage device (e.g., a disk drive), a hub, a router, a switch, and a modem or a wireless phone.", "In some embodiments, network devices may comprise one or more network components, such as a Static Random Access Memory (SRAM) device or module, a network processor, and/or a network communication path, connection, port, or cable.", "Some examples of network devices may include, but are not limited to, servers or controllers, customer devises, vending machines, input devices, output devices, and peripheral devices.", "As used herein, the terms “server” and “controller” may be used interchangeably and may generally refer to any device that may communicate with one or more vending machines, one or more third-party servers, one or more remote controllers, one or more customer devices, one or more peripheral devices and/or other network nodes, and may be capable of relaying communications to and/or from each such device.", "A controller or sever may, for example, comprise one or more network devices and/or components.", "As used herein, the terms “customer device” and “user device” may be used interchangeably and may generally refer to any device owned and/or operated by, or otherwise associated with a customer, which device is capable of accessing and/or outputting online and/or offline content.", "Customer devices may communicate with one or more servers or controllers, one or more vending machines, one or more third-party service provider servers, one or more user terminals, and/or other network devices or nodes.", "In some embodiments, customer devices may, for example, include gaming devices, PC devices, PDA devices, Point-Of-Sale (POS) terminals, point of display terminals, kiosks, telephones, cellular phones, Automated Teller Machines (ATM) devices, pagers, and/or combinations of such devices.", "In some embodiments, customer devices may communicate with vending machines and remote devices and/or computers wirelessly, through any practicable wireless communication networks, formats and/or protocols, including but not limited to those described herein.", "As used herein, the term “vending machine” may generally refer to any system, apparatus, and/or module that is operable to provide and/or facilitate the provision of goods and/or services to customers.", "Vending machines may include, but are not limited to, for example, one or more stand-alone, networked, automated, mechanical, and/or electrical devices coupled to dispense products such as beverages and/or snacks to customers.", "In some embodiments, vending machines may comprise, be coupled to, and/or may be otherwise associated with one or more input devices, output devices, and/or peripheral devices (e.g., to operate in accordance with embodiments described herein).", "As used herein, the terms “product,” “good,” “item”, “merchandise,” and “service” may be used interchangeably and may generally refer to anything licensed, leased, sold, available for sale, available for lease, available for licensing, and/or offered or presented for sale, lease, or licensing including individual products, packages of products (such as mystery packages), subscriptions to products, contracts, information, services, and intangibles.", "Examples of goods sold at vending machines may include, but are not limited to: beverages (e.g., cans or bottles of soda or water), snacks (e.g., candy bars), and recordable media (e.g., pre-recorded and/or dynamically-recorded disks or tapes).", "Examples of services sold by vending machines include car washes, photography services and access to digital content (e.g., permitting the downloading of digital picture, video, and/or audio files such as audio “ring tunes” and/or wallpapers to a handheld device).", "In some embodiments, Wi-Fi and/or other network access may comprise a product and/or service offered by a vending machine (e.g., in accordance with embodiments described herein).", "As used herein, the term “input device” may generally refer to a device that is used to receive input.", "An input device may communicate with and/or be part of another device (e.g.", "a point of sale terminal, a point of display terminal, a customer terminal, a server, a customer device, a vending machine, a controller, and/or a peripheral device).", "Some examples of input devices include, but are not limited to: a bar-code scanner, a magnetic stripe reader, a computer keyboard, a point-of-sale terminal keypad, a touch-screen, a microphone, an infrared sensor, a sonic ranger, a computer port, a video camera, a motion detector, a digital camera, a network card, a Universal Serial Bus (USB) port, a Global Positioning System (GPS) receiver, a Radio Frequency IDentification (RFID) receiver, a RF receiver, a thermometer, a pressure sensor, and a weight scale or mass balance.", "As used herein, the term “output device” may generally refer to a device that is used to output information.", "An output device may communicate with and/or be part of another device (e.g.", "a vending machine, a point of sale terminal, a point of display terminal, a customer device, and/or a controller).", "Possible output devices may include, but are not limited to: a Cathode Ray Tube (CRT) monitor, a Liquid Crystal Display (LCD) screen, a Light Emitting Diode (LED) screen, a printer, an audio speaker, an Infra-red Radiation (IR) transmitter, an RF transmitter, and/or a product hopper, dispenser, and/or data port.", "As used herein, the term “peripheral device” may refer to any device associated with one or more vending machines, the peripheral device being operable to perform in accordance with embodiments as described herein.", "For example, in one embodiment a traditional vending machine may be retrofitted with a peripheral device that comprises a processor, memory, and/or an output device for facilitating promotions such as mystery package promotions in accordance with embodiments described herein.", "A peripheral device may or may not be attached or coupled to a vending machine.", "A peripheral device may or may not be operable to direct the associated vending machine to perform certain functions.", "A peripheral device, or portions thereof, may be housed inside the casing of the associated vending machine.", "Further, a peripheral device may be operable to detect one or more events at a vending machine.", "For example, a peripheral device may be operable to detect one or more signals output by a processor of a vending machine.", "Further still, a peripheral device may be operable to communicate with a processor of an associated vending machine.", "According to some embodiments, a peripheral device (and/or a vending machine itself) may be configured to conserve coins and/or to facilitate intelligent dispensing of products.", "Some embodiments described herein are associated with an “operator”.", "As used herein, the term “operator” may generally refer to the owner of a vending machine or an agent or associate thereof (e.g., a route driver or lessee of a vending machine).", "In some embodiments, an operator may also be associated with a server or controller and/or customer devices utilized to implement embodiments described herein.", "Operators may also or alternatively be associated with the manufacture and/or distribution of one or more products or services provided via a vending machine.", "According to some embodiments, an operator may be associated with restocking one or more vending machines (e.g., on a restock date and/or at a restock time).", "As used herein, the term “promotion” may generally refer to a message that is output, regarding some product, distinct from a general offer to sell products from a vending machine at retail prices.", "For example, a promotion may comprise a message intended to increase machine profitability.", "Typically, a promotion allows customers to purchase one or more products under terms that are generally more favorable to the customer than standard retail terms (e.g., at prices less than or equal to the corresponding product's full price(s), but greater than or equal to the corresponding product's minimum price(s)).", "In some embodiments, a promotion may comprise an offer and/or incentive associated with providing Wi-Fi access to customers via the vending machine and/or another device.", "As used herein, the terms “package deal”, “combination deal”, “package promotion”, “combination promotion”, “combination product promotion”, “load-up deal”, “value combo deal”, and “combo deal” may be used interchangeably and may generally refer to any offer enabling a customer to purchase at least two products.", "In many embodiments the at least two products are sold for a single price.", "In many embodiments, the two products are dispensed to the customer essentially simultaneously (e.g., within seconds of each other).", "Typically, package offers are configured so the price of the at least two products is less than the sum of the prices of the two products, and thus the customer saves money compared to the sum of the individual component products' retail prices.", "According to some embodiments, customers may be presented with package offers that include and/or are associated with Wi-Fi access.", "As used herein, the term “package price” may generally refer to the price that is charged (typically in a single transaction) for the units of products purchased pursuant to a package offer (e.g., associated with one or more package instances).", "Typically, package prices reflect a net-savings to the customer when compared to the sum of the respective retail prices of the individual component products.", "As used herein, the term “access code” may generally refer to an alphanumeric code provided to a customer that may be used (e.g., by a vending machine) to confirm the customer's entitlement to access a communications network through one or more of a customer device and a vending machine and/or other access device.", "In one embodiment, an access code may comprise one or more of a user name, a password, a Personal Identification Number (PIN), a device's serial number, a software license number, a biometric identifier, or the like.", "Some embodiments herein are associated with “communication”.", "As used herein, the term “communication” may refer to any information, data, and/or signal that is provided, transmitted, received, and/or otherwise processed by an entity, and/or that is shared or exchanged between two or more people, devices, and/or other entities.", "As used herein, the terms “information” and “data” may be used interchangeably and may refer to any data, text, voice, video, image, message, bit, packet, pulse, tone, waveform, and/or other type or configuration of signal and/or information.", "Information may be or include information packets transmitted, for example, in accordance with the Internet Protocol Version 6 (IPv6) standard as defined by “Internet Protocol Version 6 (IPv6) Specification” RFC 1883, published by the Internet Engineering Task Force (IETF), Network Working Group, S. Deering et al.", "(December 1995).", "Information may, according to some embodiments, be compressed, encrypted, and/or otherwise packaged or manipulated in accordance with any method that is or becomes known or practicable.", "Some embodiments described herein are associated with a “communication session”.", "As used herein, the phrase “communication session” may refer to any instance and/or occurrence of a receipt, transmittal, exchange, and/or sharing of information associated with the communication between two or more parties and/or entities.", "A communication session may include, for example, an e-mail transmittal, receipt, and/or exchange, an Instant Messaging (IM) session, a voice call (e.g., over a Public Switched Telephone Network (PSTN), a cellular network, or VoIP), a file upload, download, and/or exchange, a receipt and/or transmittal of broadcast media, and/or any combination thereof.", "Communication sessions may include continuous, periodic, intermittent, and/or any other frequency of communication that is or becomes known or practicable.", "Some embodiments described herein are associated with a “communication link”.", "As used herein, the phrase “communication link” may refer to any connection, wire, port, device, and/or signal and/or any transmission, exchange, repeating, and/or other flow of information or data that is associated with the establishing, maintaining, facilitation, and/or other management and/or participation in a communication session.", "In some embodiments, a communication link may involve a “handshake”, multiplexing and/or de-multiplexing of signals, encryption and/or decryption of data, data validation, data conversion, and/or implementation of one or more compression, transmission, and/or communication protocols.", "III.", "Systems and Apparatus A.", "Introduction Generally, a vending machine for use with the some embodiments may comprise a device that is capable of (i) establishing a first communication link with a customer device, (ii) establishing a second communication link with at least one remote network device, (iii) providing and/or facilitating communication between the customer device and the at least one remote network device, (v) processing a payment, and/or (vi) dispensing a product.", "Referring first to FIG.", "1, a block diagram of a system 100 according to some embodiments is shown.", "The system 100 may comprise, for example, a customer device 102 in communication with a service provider device 104 via a network 106.This communication may generally be established by and/or facilitated via a vending machine 110 (although it should be understood that in some embodiments, other and/or additional devices may be utilized to establish and/or facilitate the communication, such as a kiosk, Automatic Teller Machine (ATM), etc.).", "According to some embodiments, the customer device 102 may gain access to the network 106 and/or the service provider device 104 by interfacing with the vending machine 110.A customer of the vending machine 110 that owns and/or operates the customer device 102 may, for example, purchase and/or otherwise acquire (e.g., via a promotion) an access code from the vending machine 110.In some embodiments, access may be associated with the purchase of a product from the vending machine 110.Communication services may be provided as part of a package deal comprising a physical product (e.g., a snack or drink) and an amount and/or duration of access to the network 106.Access may also or alternatively be provided as a gift, prize, and/or promotion that may be associated with and/or based on the customer's purchase of one or more products from the vending machine 110.In some embodiments, the customer device 102 may comprise a PC, laptop, PDA, and/or wireless or cellular telephone.", "The customer device 102 may, for example, comprise a Bluetooth®-enabled cellular telephone.", "In such embodiments, the vending machine 110 may detect and/or actively solicit the customer device 102 with the offer to access the network 106 (e.g., instead of and/or in addition to displaying messages via the vending machine 110).", "The network 106 may generally comprise any practicable and/or desirable type and/or configuration of network, such as the Internet.", "The service provider device 104 may generally comprise any type of network device such as a server, router, and/or switch that is operable to provide services to the customer device 102 and/or the vending machine 110.The service provider device 104 may, for example, be owned and/or operated by and/or otherwise associated with an Internet Service Provider (ISP) and/or a Voice over Internet Protocol (VoIP) provider.", "In the case that the customer device 102 comprises a cellular telephone, for example, the service provider device 104 may comprise one or more devices and/or systems operable to allow the customer (e.g., via the customer device 102) to place a VoIP call.", "The customer may interface with the vending machine 110 specifically to purchase and/or conduct a VoIP call, for example (such as where cellular coverage is limited and/or unavailable, or where the VoIP call may be a more economical calling option).", "Turning now to FIG.", "2, a block diagram of a vending machine 210 according to some embodiments is shown.", "In some embodiments, the vending machine 210 may be similar in configuration and/or functionality to the vending machine 110 of FIG.", "1.The vending machine 210 may comprise, for example, a casing 212 enclosing one or more of a processor 214, a communications device 216, an inventory and dispensing device 218, a payment processing device 220, an input device 222, an output device 224, and/or a data storage device 226.According to some embodiments, the vending machine 210 may be configured to perform and/or facilitate processes in accordance with embodiments described herein.", "The vending machine 210 may, for example, be utilized to offer and/or provide Wi-Fi and/or other network access (such as to the network 106 and/or service provider device 104, of FIG.", "1).", "B. Casing/Cabinetry In some embodiments, a suitable casing 212 and/or cabinetry may be constructed from any suitable material, including but not limited to any combination of (1) commercial grade sixteen-gauge steel (e.g., for exterior panels and internal shelving), (2) transparent materials such as glass or Plexiglas (e.g., for product display windows), (3) rubber (e.g., for waterproofing insulation), (4) plastic, and/or (5) aluminum.", "Many commercially available casings 212 may be adapted to work in accordance with various embodiments.", "For example, in snack machine embodiments, a suitable casing 212 may comprise the “129 SnackShop” manufactured by Automatic Products International, Ltd. of Saint Paul, Minn., which stands at seventy-two inches (72″/1829 mm) wide, has a width of thirty-eight and seven eighths inches (38 ⅞″/988 mm), and a depth of thirty-five inches (35″/889 mm).", "Other suitable snack machine casings 112 include the A La Carte® machine from Automatic Products, and the GPL SnackVendor model #159 from Crane Merchandising Systems/Crane Co. of Stamford, Conn.", "In beverage machine embodiments, casings 212 commercially available from Dixie Narco, Inc. of Williston, S.C. may be employed.", "Beverage machine casings 212 may comprise a “cooler” or “glass front” style front panel, featuring a transparent front panel (e.g., glass) enabling customers to see inventory for sale.", "Alternatively, beverage machine casings 212 may comprise a “bubble front” style front panel, featuring a decorative front panel, typically used to advertise a logo of a product manufacturer commercially interested in the operation of the vending machine 210.Other embodiments are contemplated as well, including combination snack and beverage vending machine embodiments, such as those available from Crain Co. Further details concerning the suitability of machine casings 212 and/or cabinetry are well known in the art, and need not be described in further detail herein.", "C. Processor/Controller According to some embodiments, the vending machine 210 may include the processor 214 that may be or include any type, quantity, and/or configuration of processor that is or becomes known.", "The processor 214 may comprise, for example, an Intel® IXP 2800 network processor or an Intel® XEON™ Processor coupled with an Intel® E7501 chipset.", "In some embodiments, the processor 214 may comprise multiple inter-connected processors, microprocessors, and/or micro-engines.", "According to some embodiments, the processor 214 may include or be coupled to one or more clocks or timers (not explicitly shown) and to the communication device 216 through which the processor 214 may communicate, in accordance with some embodiments, with other devices such as one or more peripheral devices, one or more servers, and/or one or more user devices (such as the customer device 102 of FIG.", "1).", "The communication device 216 may, for example, comprise any type or configuration of communication port, cable, modem, and/or signal transceiver that is or becomes known or practicable.", "According to some embodiments, the communication device 216 may comprise one or more of a Wi-Fi router 216a and a broadband modem 216b.", "The Wi-Fi router 216a may, for example, be utilized to communicate with customers and/or devices associated with customers to (i) detect the customer and/or associated devices, (ii) present an offer for network access to the customer (e.g., via the customer's associated device), (iii) receive network access signals (e.g., an activation code) and/or data fro the customer's device (e.g., facilitate network communications), (iv) receive product selection and/or payment signals from the customer's device, and/or (v) provide network information to the customer's device.", "The broadband modem 216b may generally be operable to allow communications via one or more networks and/or with one or more service providers.", "The broadband modem 216b may comprise, for example, a DSL, cable, and/or satellite modem operable to provide communications (e.g., to customers) with the Internet.", "According to some embodiments, the Wi-Fi router 216a may comprise a different device operable to communicate with customers.", "Instead of the Wi-Fi router 216a, for example, the vending machine 210 and/or the communication device 216 may comprise one or more communication ports (such that a customer may directly connect, e.g., via a cable or wire, to the vending machine 210).", "Similarly, the broadband modem 216b may alternatively comprise a wireless and/or dial-up connectivity device operable to provide access to one or more networks.", "In some embodiments, the processor 214 may also or alternatively be in communication with and/or coupled to any number of other components of the vending machine 210 such as the inventory and dispensing mechanism 218, the payment processing mechanism 220, the input device 222, the output device 224, and/or the data storage device 226.D.", "Inventory Storage and Dispensing Device In some embodiments, the vending machine 210 may comprise the inventory storage and dispensing device 218.The inventory storage and dispensing device 218 may, according to some embodiments, comprise any number and/or configuration of devices and/or components that facilitate and/or are associated with the storage and/or dispensing of products or services available via the vending machine 210.Product inventory storage and product dispensing functions of the vending machine 210 configured in accordance with a snack machine embodiment may include, for example, one or more of: (i) a drive motor, (ii) metal shelves, (iii) a product delivery system (e.g., a chute, product tray, and/or product tray door), (iv) dual spiral (e.g., double helix) item dispensing rods, (v) convertible (e.g., extendable) shelves, and/or (vi) a refrigeration unit.", "In embodiments using the casing 212 of the “model 129 SnackShop” manufactured by Automatic Products, three (3) removable shelves may be employed, together providing for thirty (30) product rows and an inventory capacity of between one hundred and eighty-five (185) to five hundred and twenty-two (522) commonly vended snack products.", "Inventory storage and distribution functions of the vending machine 210 configured in accordance with a beverage machine embodiment may include one or more conventional components, including: (i) metal and/or plastic shelving, (ii) product dispensing actuators/motors, (iii) product delivery chutes, and/or (iv) a refrigeration unit.", "In many types of beverage and snack vending machines, operators will typically stock several units of the same product linearly arranged in a column, allowing individual units to be dispensed upon command.", "The same product may be stocked in more than one column.", "Similarly, more than one product may be stocked in a single column.", "In the case that one or more services are available via the vending machine 210, the inventory storage and dispensing device 218 may comprise any device or component that is associated with the storage, transmission, encoding or decoding (e.g., including encryption and decryption), and/or other processing, routing, or electronic delivery or redemption of such services.", "Further details concerning vending machine inventory storage and dispensing devices 218 are well known in the art, and need not be described in further detail herein.", "E. Payment Processing Device According to some embodiments, the vending machine 210 may comprise the payment processing device 220.The payment processing device 220 may, according to some embodiments, comprise any number and/or configuration of devices and/or components for receiving payment and/or dispensing change, including a coin acceptor, a bill validator, a card reader (e.g., a magnetic stripe reader), and/or a change dispenser.", "In some embodiments, a magnetic stripe card reader may read data on a magnetic stripe of a credit or debit card, for example, and it may cooperate with conventional POS credit card processing equipment to validate card-based purchases through a conventional transaction authorization network.", "Suitable card-based transaction processing systems and methods are available from USA Technologies, Inc.™ of Wayne, Pa.", "In some embodiments, a coin acceptor, bill validator and/or change dispenser may communicate with and/or be coupled to a currency storage apparatus (a “hopper”; not shown) and may comprise conventional devices such as models AE-2400, MC5000, TRC200 by Mars, Inc.™ of West Chester, Pa., or CoinCo™ model 9300-L.", "Coin acceptors and/or bill validators may receive and validate currency that is stored by the currency storage apparatus.", "Further, a bill validator or coin acceptor may be capable of monitoring stored currency and maintaining a running total of the stored currency, as is discussed with reference to U.S. Pat.", "No.", "4,587,984, entitled “Coin Tube Monitor Means”, the payment and coin-related aspects of which are incorporated by reference herein.", "According to some embodiments, a change dispenser activates the return of coinage to the customer where appropriate (e.g., where a customer rejects or otherwise fails to accept a dynamically priced upsell offer).", "Such apparatus may feature Multidrop Bus (MDB) and/or Micromech peripheral capabilities, as are known in the art.", "In another embodiment, the vending machine 210 may be configured to receive payment authorization and/or product selection commands or signals through a wireless device communication network (e.g., via the communication device 216), directly or indirectly, from a customer device (e.g., a cellular telephone; not shown).", "In such an embodiment, the payment processing device 220 may comprise a cellular transceiver operatively connected to the processor 214 to receive, transmit, and/or process such signals.", "Systems and methods allowing for the selection of and payment for vending machine products via cellular telephones are provided by USA Technologies, Inc.™.", "Further, in such an embodiment, a customer cellular telephone may serve as an input device 222 and/or an output device 224, as described elsewhere herein.", "Further details concerning vending machine payment processing devices 220 are well known in the art, and need not be described in further detail herein.", "F. Input and Output Devices According to some embodiments, the vending machine 210 may comprise the input device 222 and/or the output device 224.In some embodiments, the input device 222 may be operable to receive input from (i) a customer indicating a product and/or offer selection (e.g., Wi-Fi access selection) and/or from (ii) an operator (or agent thereof) during stocking or maintenance of the vending machine 210.Also, the output device may be configured for outputting product and/or offer information (such as Wi-Fi access information and/or promotions) to a customer or operator.", "Many combinations of input devices 222 and output devices 224 may be employed according to various embodiments.", "In some embodiments, the vending machine 210 may include more than one input device 222.For example, the vending machine 210 may include an exterior input device 222 for receiving customer input and an interior input device 222 (neither shown separately) for receiving operator input.", "In some embodiments, the input device 222 may provide the dual functionality of receiving input data from both operators and customers.", "Likewise, a vending machine may comprise more than one output device 224 (e.g., an LCD screen and several LED devices, as described herein).", "In some embodiments, such as those which feature touch screens (described elsewhere herein), the functionality of both input devices 222 and output devices 224 may be provided by a single device.", "Many input devices 222 are contemplated.", "Thus, an input device 222 may comprise one or more of the following: (i) a set of alpha-numeric keys for providing input to the vending machine, such as the Programmable Master Menu® Keypad, (ii) a selector dial, (iii) a set of buttons associated with a respective set of item dispensers, (iv) a motion sensor, (v) a barcode reader (e.g., a 1-D or 2-D barcode reader), (vi) a voice recognition module, (vii) a Dual-Tone Multi-Frequency receiver/decoder, (viii) a wireless device (e.g., a cellular receiver; a radio-frequency receiver; an infrared receiver; a wireless access point or wireless router; other wireless devices), (ix) a smart card reader, (x) a magnetic stripe reader, (xi) a biometric identification apparatus (e.g., an iris scanner, a retinal scanner, a thumbprint reader, etc.", "), (xii) a customer device, and/or (xiii) any other type or configuration of input device 222 that may be or become known or practicable.", "In some embodiments, an input device 222 may comprise an optical reader (e.g., a 2-D bar code scanner) capable of scanning a barcode, such as a bar code which is displayed on a screen or monitor of a user's cellular phone, PDA, Blackberry® business phone, Blackberry® handheld or other handheld device.", "One system employing such technology, the Cmode® service, has been developed by a partnership between Coca-Cola® Co. and NTT DoCoMo™ Inc. of Japan.", "Likewise, many types of output devices 224 are contemplated.", "For example, an output device may comprise an LCD screen or device.", "Alternatively or additionally, the output device 224 may comprise one or more LED displays or devices (e.g., several alphanumeric multi-color or single color LED displays on the shelves of a vending machine associated proximately with each row of product inventory).", "In one embodiment, an LED display screen is mounted atop the vending machine (via bolts or other mounting hardware) and is used to communicate offers and other messages (e.g., product advertisements, such as Wi-Fi access offers) to prospective customers.", "A suitable LED display screen for such an embodiment may be housed in an aluminum case having a length of approximately twenty-seven and one half inches (27.5″/698.5 mm), a height of approximately four and one quarter inches (4.25″/107.95 mm), and a depth of approximately one and three quarter inches (1.75″/44.5 mm).", "Such a display screen may have a display area capable of showing about thirteen (13) alphanumeric and/or graphical characters.", "Further, such an LED display screen may comprise a serial computer interface, such as an RJ45/RS232 connector, for communicating with the processor 214.Further still, such an LED display may be capable of outputting text and graphics in several colors (e.g., red, yellow, green, black) regarding current and upcoming promotions.", "Further, in some embodiments, the output device 224 may comprise a printer.", "In one embodiment, a printer may be configured to print on card stock paper of approximately one hundredth of an inch or less (e.g., 0.01″/0.15 mm or less) in thickness, such as the EPSON EU-T400 Series Kiosk Printer.", "Further, a printer may be capable of thermal line printing of various alphanumeric and graphical symbols in various font sizes (e.g., ranging from nine (9) to twenty-four (24) point) on various types of paper.", "Additionally, such a printer may communicate with the processor 114 via an RS232/IEEE 12834 and/or bi-directional parallel connection.", "Such a printer may further comprise a data buffer of various practicable sizes, such as approximately four kilobytes (4 KB).", "In some embodiments, the printer may be operable to output Wi-Fi access codes to customers and/or to print stickers, labels, and/or other indications to be attached to products vended by the vending machine 210.The output device 224 may also comprise a device operable to attach and/or print indications of access codes onto one or more products of the vending machine 210 (e.g., as the products are loaded by an operator, while the products are shelved within the vending machine 210, and/or as the products are dispensed—such as a hopper printing and/or coupling mechanism).", "According to some embodiments, the output device 224 may also or alternatively comprise an audio module, such as an audio speaker, that outputs information to customers audibly.", "As stated, in some embodiments, a touch-sensitive screen may be employed to perform both input device 222 and output device 224 functions.", "Suitable, commercially available touch screens for use according to various embodiments are manufactured by Elo TouchSystems, Inc., of Fremont, Calif., such as Elo's AccuTouch series touch screens.", "Such touch screens may comprise: (i) a first (e.g., outer-most) hard-surface screen layer coated with an anti-glare finish, (ii) a second screen layer coated with a transparent-conductive coating, and/or (iii) a third screen layer comprising a glass substrate with a uniform-conductive coating.", "Further, such touch screens may be configured to detect input within a determined positional accuracy, such as a standard deviation of error less than plus or minus eight hundredths of an inch (±0.08″/2 mm).", "The sensitivity resolution of such touch screens may be more than one hundred thousand touchpoints per square inch (100,000 touchpoints/in2/15,500 touchpoints/cm2) for a thirteen inch (13″) touch screen.", "For such touch screens, the touch activation force required to trigger an input signal to the processor 214 via the touch screen may typically be around two to four ounces (2-4 ounces/57-113 g).", "Additionally, touch screens for use according to various embodiments may be resistant to environmental stressors such as water, humidity, chemicals, electrostatic energy, and the like.", "These and other operational details of touch screens (e.g., drive current, signal current, capacitance, open circuit resistance, and closed circuit resistance) are well known in the art and need not be described further herein.", "In some embodiments, input and/or output functionality of the vending machine 210 may be facilitated through a wireless device configured to send data to, and/or receive data from, a customer device (e.g., the customer device 102 of FIG.", "1), such as a laptop computer or a cellular telephone.", "In some embodiments, such a wireless device may comprise a sensor that detects signals from a customer device.", "Such signals may include but are not limited to radio frequency signals and/or Infrared Radiation (IR) signals.", "Thus, in one or more embodiments, a wireless input device 222 may comprise a WAP or router configured to operate in accordance with an IEEE 802.11 standard, including the 802.11b and 802.11g standards, which transmit at 2.4 GHz, or the 802.11a standard, which transmits at 5 GHz.", "Such a wireless input device 222 may, in some embodiments, have the capability to “frequency hop” between radio frequencies so as to reduce interference and/or increase security.", "Encryption techniques may also or alternatively be employed to increase the security of transmissions.", "Suitable WAPs are available from Belkin™ Corporation of Compton, Calif. and Cisco™ Systems, Inc. of San Jose, Calif.", "The wireless input device 222 may, in some embodiments, be used to establish a communication link (such as a first communication link with a customer device) as described herein.", "G. Data Storage/Memory The data storage device 226 may include any appropriate combination of magnetic, optical and/or semiconductor memory, and may include, for example, additional processors, communication ports, RAM, Read-Only Memory (ROM), a compact disc and/or a hard disk.", "The processor 214 and the storage device 126 may each be, for example: (i) located entirely within a single computer or other computing device; or (ii) connected to each other by a remote communication medium, such as a serial port cable, a Local Area Network (LAN), a telephone line, RF transceiver, a fiber optic connection and/or the like.", "In some embodiments for example, the vending machine 210 may comprise one or more computers (or processors 214) that are connected to a remote server computer (e.g., via the communication device 216) operative to maintain databases, where the data storage device 226 is comprised of the combination of the remote server computer and the associated databases.", "The data storage device 226 may generally store one or more programs 228 for controlling the processor 214.The processor 214 may perform instructions of the program 228, for example, and thereby operate in accordance with some embodiments, and particularly in accordance with the methods described in detail herein.", "According to some embodiments, the program 228 may comprise any number or type of programs that are or becomes known or practicable.", "In some embodiments, the program 228 may be developed using an object oriented programming language that allows the modeling of complex systems with modular objects to create abstractions that are representative of real world, physical objects and their interrelationships.", "However, it would be understood by one of ordinary skill in the art that the embodiments described herein can be implemented in many different ways using a wide range of programming techniques as well as general purpose hardware systems or dedicated controllers.", "The program 228 may be stored in a compressed, un-compiled and/or encrypted format.", "The program 228 furthermore may include program elements that may be generally useful, such as an operating system, a database management system and/or device drivers for allowing the processor 214 to interface with computer peripheral devices and/or the various components of the vending machine 210.Appropriate general purpose program elements are known to those skilled in the art, and need not be described in detail herein.", "Further, the program 228 may be operative to execute a number of invention-specific objects, modules and/or subroutines which may include (but are not limited to) one or more subroutines to determine whether a promotion should be output; one or more subroutines to determine a promotion type; one or more subroutines to populate a promotion type (such as a mystery promotion), thereby constructing a promotion instance; one or more subroutines to select a constructed promotion instance from a plurality of hypothetical promotion instances; one or more subroutines to determine an expected value of a promotion being considered for output; one or more subroutines to determine how and/or when products should be dispensed from the vending machine 210; one or more subroutines to determine access codes associated with Wi-Fi access; and/or one or more subroutines to provide and/or facilitate Wi-Fi access.", "Examples of some of these subroutines and their operation are described in detail with respect to the processes described elsewhere herein.", "According to some embodiments, the instructions of the program 228 may be read into a main memory (not explicitly shown) of the processor 214 from another computer-readable medium (such as the data storage device 226), like from a ROM to a RAM.", "Execution of sequences of the instructions in the program 228 may cause the processor 214 to perform the process steps described herein.", "In alternative embodiments, hard-wired circuitry or integrated circuits may be used in place of, or in combination with, software instructions for implementation of the processes described herein.", "Thus, some embodiments are not limited to any specific combination of hardware, firmware, and/or software.", "In addition to the program 228, the data storage device 226 may also be operative to store one or more databases, files, and/or tables, containing information such as (i) product inventory data 230, (ii) dispensing data 232, (iii) coin inventory data 234, (iv) transaction history data 236, (v) promotion history data 238, (vi) available promotions data 240, (vii) rules data 242, and/or (viii) customer data 244.Any number of other arrangements may be employed besides those suggested by the tables shown.", "For example, even though eight separate data tables, stores, files, and/or databases are illustrated, embodiments may be practiced effectively using fewer or more functionally equivalent databases or similar structures.", "These databases and/or other databases (not shown) may also or alternatively store information associated with Wi-Fi access.", "Transmission logs, available service providers and/or networks, identified customer devices, network statistics (e.g., usage, bandwidth, performance), and/or other metrics may, for example, be stored to facilitate the providing of Wi-Fi access via the vending machine 210.Further, despite the depiction of the data as tables, an object-based model could be used to store and manipulate the data types and likewise, object methods or behaviors can be used to implement the processes described herein.", "H. Vending Machine Retrofitting In some embodiments, one or more of the processor 214, the input device 222, the output device 224, and the data storage device 226 may be included, wholly or partially, in a separate device (e.g., separate from and/or external to the casing 212; not shown), such as the e-Port™ by USA Technologies Inc., that may be in communication with the vending machine 210.The separate devices may also or alternatively be in communication with a network such as the Internet (e.g., via the communication device 216).", "The e-Port™ is a credit and smart card-accepting unit that controls access to office and MDB vending equipment, and serves as a point of purchase credit card transaction device.", "The e-Port™ includes an LCD that allows for the display of color graphics, and a touch sensitive input device (touch screen) that allows users to input data to the device.", "The display may be used to prompt users interactively with, e.g., offers and information about their transaction status.", "The separate device may alternatively be a programmed computer running appropriate software for performing various functions described herein.", "The separate device may be operable to receive input from customers, receive payment from customers, exchange information with a remotely located server (e.g., an ISP server, a VoIP service provider's server) and/or display messages to customers (e.g., Wi-Fi access promotions).", "The separate device may be operable to instruct the vending machine that appropriate payment has been received (e.g., via a credit card read by the separate device), that a particular product or products should be dispensed by the vending machine, and/or how and/or when those products should be dispensed (e.g., to avoid product collisions and/or other complications).", "Further, a separate device may be operable to instruct the vending machine to execute Wi-Fi access promotions (package or single product Wi-Fi access promotions), price changes, or the like.", "Thus, a separate device may be operatively connected to a vending machine 210 to perform various processes and steps described herein including the establishment of communication links to provide Wi-Fi access, such as the first and second communication links described herein.", "In this manner, conventional vending machines may be retrofitted with such separate devices so as to perform the processes described herein.", "I.", "Other Separate Devices It should be noted that, in some embodiments, some or all of the functions and method steps described herein may be performed partially or entirely by one or more separate devices (not explicitly shown), which are not necessarily retrofitted to a vending machine 210.Separate devices for use with such an embodiment include, but are not limited to, kiosks and customer devices (PDA devices, laptop computers, and cellular telephones).", "In some embodiments featuring separate devices, such devices may be capable of communicating, directly (e.g., via Bluetooth® connectivity) or indirectly (e.g., through a web server or IVRU), to a vending machine control system in order to facilitate the inventive functionality described herein.", "In some embodiments featuring separate devices, such separate devices are capable of communicating with a remote computer.", "J.", "Network Embodiments Network environments may include a remotely located device or computer (e.g., a server, mainframe, or other device) that is in communication, via a communications network, with one or more vending machines 210 and/or customer devices.", "Such a configuration may facilitate a second communication link as described herein.", "The remote device or computer may communicate with the vending machines 210 and/or customer devices, and the vending machines 210 may communicate with each other, directly or indirectly, via a wide variety of wired and/or wireless means, mediums, protocols and communications standards.", "Some, but not all, possible communication links and networks that may comprise the network or be otherwise part of the system include but are not limited to: PSTN links, satellite links, cellular links, optical links, infrared links, radio frequency links, and/or Cable TV links.", "Various networking configurations, standards and protocols may be employed, including but not limited to: IP addressing via the Internet, a local area network (LAN), a wireless LAN, a wide area network (WAN), Ethernet (or IEEE 802.3), Token Ring, SAP, ATP, Bluetooth, TCP/IP and/or via any appropriate combination thereof.", "Communication may be encrypted to ensure privacy and prevent fraud in any of a variety of ways well known in the art.", "Access to one or more communications networks described herein may be governed by a network service account maintained with a commercial service provider, bulletin board system or the like.", "Example of service providers include but are not limited to ISPs and VoIP service providers.", "Accounts and/or corresponding network service may be accessed via dial-up, cable, DSL, T1, T3, cellular or other methods.", "Thus, in one or more embodiments, a vending machine 210 and/or operator thereof maintains a network service account with a service provider so that customers of a vending machine may access a communications network via a first communication link (between a vending machine and a customer device) and a second communication link (between a vending machine and a remote device or computer, such as a service provider's server; between a customer device and a remote device or computer).", "All or a portion of the costs of maintaining such a network service account may be passed on to the customer of the vending machine, such as by (1) raising the prices of physical goods vended from the vending machine, or (2) charging a fee (independent of the purchase of physical goods from the vending machine).", "A vending machine and/or operator associated therewith may charge “upfront” fees (e.g., six dollars ($6) for one (1) hour of Wi-Fi Internet access; twenty dollars ($20) per month for unlimited Wi-Fi Internet access); or fees may be levied ex post facto, based on the customer's usage (e.g., a “Pay-as-you-go” account), where fees are deducted from a previously identified financial account, such as a credit/debit card account.", "Thus, a vending machine 210 and/or operator associated therewith may establish “sub accounts”, which entitle customers to use the network service account that the vending machine 210 and/or operator maintain with a service provider.", "In other embodiments, a vending machine 210 and/or operator associated therewith may not charge customers for access to its network service account, as Applicants have recognized that the cost of maintaining such a network service account with a service provider and allowing vending machine customers to freely access such an account may be sufficiently offset by a resulting increase in sales volume for traditionally vended physical goods, such as snacks and drinks.", "Vending machines 210 may comprise computers, such as those based on the Intel® Pentium® or Centrino™ processor, that are adapted to communicate with the remote device or computer.", "Any number and type of machines may be in communication with the remote device or computer.", "Those skilled in the art will understand that vending machines 210, devices and/or computers in communication with each other need not be continually transmitting to each other.", "On the contrary, such vending machines, devices and/or computers need only transmit to each other as necessary, and may actually refrain from exchanging data most of the time.", "For example, a vending machine in communication with another machine via the Internet may not transmit data to the other machine for weeks at a time.", "In some embodiments, the remote device or computer may be accessible, directly or indirectly, via a separate device (such as a customer device) by a customer or operator.", "Accordingly, a customer or operator may use a device to communicate with the remote computer.", "A separate device may receive from the remote computer messages described herein as being output by the vending machine 210 (e.g., access codes), and/or may transmit to the remote computer input described herein as being provided to the vending machine 210 (e.g., access codes).", "Thus, various data described herein as received through an input device of a vending machine 210 may be received by the vending machine 210 from a separate device (e.g., through a Bluetooth® connection) or from a remote computer (which may relay data first received from a customer device such as a personal computer).", "Similarly, various data described herein as received through an input device 222 of a vending machine 210 may be received through a Web browser communicating with a remote server, which in turn communicates with the vending machine 210.K.", "External Appearance Referring to FIG.", "3, a diagram illustrating an example of the external appearance of a vending machine 310 according to some embodiments is shown.", "In some embodiments, the exemplary vending machine 310 may be similar in configuration and/or functionality to the vending machines 110, 210 described in conjunction with any of FIG.", "1 and/or FIG.", "2.The exemplary vending machine 310 may comprise, for example, (i) a cabinet 312, (ii) an inventory dispensing mechanism 318a-b (comprising a product storage mechanism 318a and/or a product hopper 318b), (iii) a payment processing mechanism 320, (iii) an output device 324 (e.g., for outputting text and/or graphical information about promotions such as Wi-Fi access promotions to a customer), and (iv) a product display window 346 behind which are visible the products 348 available for sale from the vending machine 310 and the product storage mechanism 318a that holds the products within the vending machine 310.According to some embodiments, the components 312, 318, 320, 324, 346 of the vending machine 310 may be similar in configuration and/or functionality to the similarly named and/or numbered components described in conjunction with FIG.", "2 herein.", "The casing 312 may, fore example, comprise any type or configuration of cabinetry or enclosure to at least partially house components of the vending machine 310.As described elsewhere herein, for example, the casing 312 may be constructed of steel, aluminum, plastic, rubber, other metals or composite materials, and/or any combinations thereof.", "In some embodiments, the casing 312 may be configured for the sale of various products or services such as a typical and/or modified version of a typical snack, beverage, dessert, meal, non-edible object, media, and/or any other vending machine 310.According to some embodiments, the inventory dispensing mechanism 318a-b may comprise various component such as the product storage mechanism 318a and/or the product hopper 318b).", "The product storage mechanism 318a may, for example, comprise a number of latches, levers, paddles, doors, spirals, and/or other product retention, detention, and/or dispensing mechanisms, as are known in the art.", "According to some embodiments, a product selected and/or purchased by a customer may be released by the product storage mechanism 318a so that it falls into the product hopper 318b.", "The product hopper 318b may, according to some embodiments, comprise one or more doors, holes, and/or other means via which a customer may retrieve a dispensed product.", "The product hopper 318b may also or alternatively comprise one or more components to facilitate prevention of unauthorized product removal (e.g., from someone reaching up into the vending machine 310 via the product hopper 318b) and/or to facilitate the reduction of impact forces experienced by products dropping from the product storage mechanism 318b above.", "In some embodiments, the payment processing mechanism 320 may comprise any practicable type of payment receiving, transmitting, and/or processing device that is or becomes known (such as those described elsewhere herein).", "The payment processing mechanism 320 may, for example, comprise a currency validator and/or input slot, such as shown in FIG.", "3.According to some embodiments, the output device 324 may display various information associated with Wi-Fi access promotions and/or product or service sales to a customer.", "As shown in FIG.", "3, for example, the output device 324 may comprise a display screen (and/or touch screen) that advertises the availability of Wi-Fi access via the vending machine 310.The particular offer shown in FIG.", "3, for example, allows a customer to pay one dollar ($1) to receive a snack and five (5) minutes of Wi-Fi Internet access.", "In accordance with some embodiments, the snack and/or other product “packaged” with the network access may comprise a “mystery” product selected by the vending machine 310, such as to manage inventory and/or sales.", "Various mystery and mystery package embodiments are described in Applicant's co-pending U.S. application Ser.", "No.", "11/282,525, entitled “SYSTEMS AND METHODS FOR VENDING PROMOTIONS” and filed on Nov. 18, 2005, the mystery product and mystery package concepts of which are hereby incorporated by reference herein.", "IV.", "Processes One benefit of some embodiments is an increase in vending machine profits (e.g., per fill period).", "Applicants have recognized, for example, that by providing Wi-Fi access via a vending machine, the overall profitability of a vending machine can be increased (e.g., by direct profits from Wi-Fi access charges and/or via increased ancillary sales of other products from the vending machine).", "According to some embodiments, a general process designed to increase the profitability of a vending machine within a given fill period and/or provide Wi-Fi access is stored in the memory of a vending machine and is executed by the control system (e.g., the processor, RAM, ROM, and/or software).", "The control system may be the control system of a vending machine 110, 210, 310, the control system of a peripheral device, the control system of a controller, the control system of a peripheral controller, and/or a control system of a combination of any or all of these devices.", "Generally, from the control system's perspective, the general process may include the three basic steps of (i) receiving, by a vending machine, a request from a customer to initiate a communication session; (ii) establishing a first communication link between the vending machine and a device associated with the customer; and (iii) establishing a second communication link between the vending machine and a remote network device, such that a communication session is established between the device associated with the customer and the remote network device.", "The process may further comprise (a) receiving payment from the customer, (b) determining a price to charge the customer for the establishing of the communication session between the device associated with the customer and the remote network device, (c) receiving an indication, from the customer, of a selection of a product sold by the vending machine, and/or (d) dispensing the selected product.", "Turning to FIG.", "4, for example, a flow diagram of a method 400 according to some embodiments is shown.", "The method 400 may comprise, for example, a method for providing Wi-Fi access to customers.", "In some embodiments, the method 400 (or portions thereof), and all other processes described herein unless expressly specified otherwise, may be performed, for example, by a vending machine 110, 210, 310, a peripheral device, a controller, a peripheral device controller, a user device, another computing device, and/or any combination thereof.", "Additionally, while some of the steps of a process may be performed by a first device, other steps may be performed by another device and/or a combination of devices.", "Further, the method 400, and all other processes described herein unless expressly specified otherwise, may include steps in addition to those expressly depicted in the figures or described in the specification without departing from the spirit and scope of some embodiments.", "Similarly, the steps of the method 400 and any other process described herein, unless expressly specified otherwise, may be performed in an order other than depicted in the figures or described in the specification, as is practicable and/or appropriate.", "In some embodiments, the method 400 may begin at 402, by receiving, by a vending machine, a request from a customer to initiate a communication session.", "In response to an advertisement and/or offering of the vending machine, for example, the customer may indicate a desire to obtain Wi-Fi access via the vending machine.", "The customer may provide the indication via any practicable means.", "The customer may make a selection via a menu and/or button provided by the vending machine, for example, and/or the customer may utilize en electronic device (e.g., the customer device 102 of FIG.", "1) to provide the indication.", "The request may take several forms and/or be indicated through one or more customer-initiated actions, including but not limited to: (i) a signal indicating an acceptance of an offer; (ii) a signal indicating a product selection (e.g., where network access is marketed as a premium/bonus product or as part of a package of products); (iii) a signal indicating that a payment has been tendered and/or validated (e.g., a bill validator has detected and approved a tendered bill; a remote computer has instructed a vending machine that a presented credit card account number has been validated); (iv) a signal indicating a particular payment identifier (e.g., a customer's prepaid unit account number); (v) a signal indicating a customer identifier (e.g., a customer's account number); (vi) a signal indicating a customer device identifier (e.g., a cell phone number as determined through Automatic Number Identification (ANI) technology; a computer's serial number or a software license number).", "In some embodiments, the indication may be received via an electronic customer device (and/or directly from the customer) in response to an offer that is actively sent to the customer's device.", "A Bluetooth®-enabled vending machine may detect the presence of a Bluetooth®-enabled customer device, for example, and send an offer and/or advertisement for Wi-Fi access to the customer via the customer's device.", "According to some embodiments, the customer may respond to the offer and/or indicate an acceptance of the offer via the customer's device.", "In some embodiments, the indication of the request may also provide indications of information associated with the offer, request, and/or requested access.", "The request may indicate, for example, one or more parameters associated with the access, such as a requested duration, speed, bandwidth, format (e.g., protocol), and/or other characteristic of the Wi-Fi access.", "According to some embodiments, the method 400 may continue by establishing a first communication link between the vending machine and a device associated with the customer, at 404.In one embodiment, a vending machine establishes the first communication link by wirelessly communicating with a customer device, through any wireless communications protocol, method, standard or format, as described herein.", "For example, in one embodiment, a vending machine may wirelessly communicate with a customer's laptop computer through a wireless 802.11b access point (e.g., incorporated into and/or associated with the vending machine), as described herein.", "In some embodiments, a vending machine may wirelessly communicate with a customer's cellular telephone by using the Bluetooth® wireless protocol, as is known in the art.", "According to some embodiments, the first communication link may already have been established at 402.In the case that communication of the request and/or a communication of a Wi-Fi access offer are conducted wirelessly between the vending machine and a customer device, for example, the first communication link may be established at 404, via and/or in conjunction with the communications conducted at 402.In one or more embodiments, a vending machine may communicate with a customer device through a wired connection, such as through a serial data cable, USB interface, etc.", "The customer may be prompted and/or directed to connect a wire and/or cable to a specific port on the vending machine, for example.", "In some embodiments, the customer may be further and/or otherwise directed to utilize the communication network.", "The vending machine, a customer device, and/or a remote device or computer may output a message to a customer, for example, prompting the customer to utilize a communication network, such as the Internet, a PSTN, etc.", "In one embodiment, the customer is prompted through static (e.g., painted) signage on the vending machine.", "For example, a painted sign may read: “10 minutes of free Internet access with the purchase of any Coca-Cola® product.” Alternatively, a vending machine, a customer device, and/or remote device or computer may output a message to a customer through an output device such as a touch screen, an LCD screen, or an audio speaker.", "In one or more embodiments, a vending machine and/or remote device or computer may output a message to a customer device, for output to the customer through an output device of the customer device (e.g., a cellular phone's LCD screen).", "In some embodiments, a determination of whether the output of such a prompt is appropriate, necessary, and/or desirable for some business purpose, may be made.", "For example, a database of stored rules may guide a processor of a vending machine or a remote device or computer to output such a prompt only if certain conditions are satisfied.", "Such conditions include but are not limited to (i) time of day conditions, (ii) inventory conditions, (iii) sales conditions, (iv) customer identifier or customer status conditions, (v) customer proximity conditions, and/or (vi) other conditions.", "For example, in an embodiment, a condition may provide that network access should only be marketed through prompts during certain times of day, such as after 6:00 PM, when vending machines sales are typically slow, and/or when network access prices are lower (e.g., if telephonic communication rates are lower at night).", "In another embodiment, if current inventory of one or more products in one or more vending machines is greater or less than a certain threshold, a prompt may be output.", "Such an inventory condition may function to encourage customers to visit a vending machine and potentially purchase physical (e.g., food) products when inventory is in abundant supply.", "Alternatively or additionally, a condition may provide that network access should be marketed through prompts only when sales conditions indicate that a certain threshold sales volume is lacking or has been exceeded.", "In another embodiment, the vending machine may output a message to only a certain class or type of customers, such as customers who have previously established a prepaid user account, as described with reference to Applicants' co-pending U.S. Patent Publication No.", "US2004/041561 (the user account concepts and descriptions of which are hereby incorporated by reference herein), or customers who have previously registered as members, as described with reference to Applicants' co-pending U.S.", "Provisional Patent Application Ser.", "No.", "US 60/583,653 (the member registration concepts and descriptions of which are hereby incorporated by reference herein).", "For example, a customer may enter a customer identifier at a vending machine through the vending machine's touch screen, and the vending machine may determine that the customer has previously established an account or membership, and output a prompt for Wi-Fi access and/or service accordingly.", "In another embodiment, a vending machine and/or remote device or computer may output a message to a customer device only if it is determined that a customer (or a customer device) is within a certain geographic area of one or more vending machines.", "For example, a computer may determine, through cellular triangulation and/or other techniques, that a customer and/or the customer's cell phone, is within X miles of a vending machine, and may transmit a text message to the cell phone, prompting the customer with a network access offer.", "In some embodiments, the method 400 may continue at 406, by establishing a second communication link between the vending machine and a remote network device, such that a communication session is established between the device associated with the customer and the remote network device.", "In some embodiments, payment and/or consideration may be received from the customer prior to establishing the second communications link at 406.The customer may be required to provide payment electronically (e.g., via the customer's device), by inserting cash and/or coin into the vending machine, by swiping a credit and/or debit card, and/or be any other practicable means.", "In some embodiments, as described herein, the payment received from the customer may also be associated with another product and/or service provided by the vending machine.", "The customer may pay for a package that includes the Wi-Fi access and another product (such as a snack or drink), for example, or may pay only for the other product and may receive the Wi-Fi access as a bonus, gift, and/or prize.", "According to some embodiments, a vending machine and/or remote device or computer may establish the second communication link with the remote network device such that the customer device may be able to send data to and/or receive data from the remote network device.", "While this may generally comprise utilizing the vending machine as a router, switch, hub, and/or intermediate facilitation device between the customer device and the remote network device, it should be appreciated that the vending machine may also or alternatively cause the second communication link to be initiated between the customer device and the remote network device directly (such as be sharing connection information and/or addresses with the devices).", "In some embodiments for example, the second communication link comprises an indirect communication link between a customer device and a remote device or computer, where a vending machine communicates with a customer device (e.g., through the first communication link) and also communicates with the remote device or computer, thereby allowing the customer device to communicate indirectly with the remote device or computer (i.e., through the vending machine).", "For example, in one embodiment, a customer establishes a first communication link between a customer device and a vending machine through the vending machine's WAP.", "The vending machine, in turn, permits the customer device to access the Internet.", "Alternatively, a first communication link need not be continued and/or maintained while a second communication link is continued or maintained.", "For example, in one embodiment, a customer may transact with a vending machine through a customer device (e.g., through a first communication link) to purchase network access (e.g., by purchasing an access code).", "Then, the customer (and/or the vending machine) may terminate the first communication link between the vending machine and the customer device, and may establish a second communication link between the customer device and a remote device or computer so that the customer may access a communications network, as agreed.", "Thus, in one embodiment, a second communication link comprises a direct link between a customer device and a remote computer or device.", "It should be noted that the terms “first communication link” and “second communication link” should not imply an order or sequence for establishing such communication links.", "That is, in one embodiment, a second communication link (between a vending machine and a remote network device or between a customer device and a remote computer) may be established before a first communication link (between a customer device and a vending machine) is established.", "In another embodiment, a first communication link is established prior to a second communication link.", "In one embodiment, while a second communication link is enabled or maintained, data is output to a customer, through a vending machine or a customer device, informing the customer about the customer's usage of the communication network.", "For example, a customer device may output a message indicating “10 minutes of surf time remaining” or “9 units remaining.” Such a message may be output visually (e.g., through an LCD screen) or audibly (e.g., through a speaker).", "Further, a customer account or database record may be updated on a periodic or substantially continuous basis to reflect usage and/or time elapsed since the establishment of a second communication link.", "Referring now to FIG.", "5, a flowchart of a method 500 according to some embodiments is shown.", "In some embodiments, the method 500 may be related to the method 400 of FIG.", "4.The method 500 may, for example, comprise processes that are a continuation and/or are supplemental to those of the method 400 of FIG.", "4.According to some embodiments, the method 500 may begin at 502 by receiving, by a vending machine, an indication of a selection of a product sold by the vending machine.", "The indication may generally be received in any practicable manner, such as described in conjunction with the receiving of the communication session request indication at 402 of the method 400 of FIG.", "4.A customer may, for example, use conventional product selection means and/or techniques to indicate a desire to purchase one or more products from the vending machine.", "In some embodiments, the customer may indicate a desire to purchase a package of products, as described herein.", "According to some embodiments, the selection of the product may be associated with Wi-Fi access.", "The customer may select one or more products, for example, that are packaged with, come with, and/or provide the possibility of winning Wi-Fi access.", "In some embodiments, the method 500 may continue by receiving, from a customer, payment for the selected product, at 504.The customer may provide cash, coin, electronic debit, credit card, and/or any other practicable payment and/or payment authorization.", "According to some embodiments, the customer may select (e.g., at 502) and purchase (e.g., at 504) a vended product in a conventional manner.", "In some embodiments, the amount and/or type of payment may be determined and/or processed.", "Payment may be processed by a vending machine and/or by a remote device or computer, for example, using any conventional payment processing apparatus or method, including bill validators and associated methods, credit card processing apparatus and associated methods, and the like, including but not limited to those described herein.", "Alternatively or additionally, as vending machines configured in accordance with some embodiments function as Internet nodes, any payment method available on the web (pay-pal™, electronic wallets, Microsoft™ passport, etc.)", "may be accepted by a vending machine as a viable payment option.", "Thus, according to some embodiments, a vending machine may receive a product selection and a payment identifier from a customer, and use the presented payment identifier to obtain authorization, over the Internet, from a remote computer.", "At 506, the method 500 may continue by dispensing the product to the customer.", "In some embodiments, the product may comprise an indication of a communication session activation code.", "The vending machine may be instructed, for example, to dispense a physical product (e.g., the product indicated as selected at 502), such as a food or beverage item.", "In one embodiment, where network access is bundled as a component in a package that also includes a physical food item, a customer may be permitted to access a communication network and select a physical food item, which is dispensed from the machine so that the customer may enjoy the food item while accessing the network.", "For example, a customer may enjoy a Coca-Cola® soda while accessing the Internet to check e-mail, or while accessing a VoIP service to make substantially discounted long distance phone calls.", "According to some embodiments, the product dispensed may comprise an indication of an activation code that the customer may utilize to obtain Wi-Fi access via the vending machine.", "An access code may be printed on and/or otherwise indicated by the product and/or product packaging, for example.", "In some embodiments, only some product in the vending machine may indicate such access codes.", "Customers may be allowed and/or given an incentive to pick Wi-Fi associated products, for example, or random products stored in the machine may comprise such indications.", "In the latter example, the customer may receive the access code as a prize, bonus, and/or gift.", "The indications may generally be hidden from the customer in such embodiments (e.g., to preserve surprise and/or mystery) or may be easily viewable, such that a customer may be likely to purchase more products to cause the dispensing of a product that is associated with Wi-Fi access (e.g., that is located behind other products with the vending machine).", "It should be noted that the access code may be otherwise provided to the customer.", "In the case that the customer purchases and/or is provided with Wi-Fi access, for example, the vending machine may display the access code to the customer, print an indication of the code for the customer, and/or send the code to the customer (e.g., via the customer's device and/or via the first communication link).", "In some embodiments, the access code may be determined by the vending machine and/or a peripheral device.", "In one or more embodiments for example, a vending machine, customer device and/or remote device or computer may determine an access code.", "In such embodiments, an access code may be subsequently required by the system in order to provide Wi-Fi access (e.g., in order to establish the second communications link, as described herein).", "In one or more embodiments, access codes may be substantially unique alphanumeric codes.", "Access codes may be determined in one or more ways.", "For example, an access code may be generated based on an algorithm which creates a string of digits that may be verified through a checksum, as is known in the art.", "In another embodiment, an access code may be selected from a list of sequential numeric codes or otherwise selected from a database of previously established codes.", "It should be noted that in one or more embodiments access codes might be suggested or provided by a customer.", "For example, a customer may provide a credit or debit card number, a social security number, a biometric identifier, a vending machine account or membership identifier, or the like.", "It should be noted that in some embodiments, access codes might not be necessary and/or preferred.", "For example, in one or more embodiments, a customer may establish a first communication link between a vending machine and the customer device, and the customer may proceed to request and/or pay for network service through the customer device.", "In such an embodiment, a vending machine or computer associated therewith may restrict access to a communications network to customers who have paid for such access via a first communications link.", "In embodiments where an access code is required and/or desirable, the method 500 may continue by receiving an indication of the communication session activation code, at 508.Upon receiving the code (e.g., via the vending machine, e-mail, and/or as indicated by a dispensed product), for example, a customer may enter the code into the vending machine to initiate and/or redeem Wi-Fi access.", "In some embodiments, the customer may provide and/or indicate the code at a later date and/or time (such as by returning to the vending machine, and/or by interfacing with another vending machine associated with the first vending machine).", "The code may be received directly (e.g., through a keypad) or indirectly (e.g., through a customer device).", "The received access code may be temporarily stored in RAM pending an evaluation, verification, and/or authorization.", "According to some embodiments, the access code may be validated.", "The vending machine and/or remote device or computer may attempt, for example, to validate the access code received from the customer at 508.In one embodiment, the vending machine and/or remote device or computer attempts to validate the access code by comparing the one received to the one issued (and temporarily stored in RAM).", "Should the presented access code match the issued access code, the process may continue, otherwise Wi-Fi access may be denied.", "In one embodiment, the vending machine and/or remote device or computer performs a checksum validation, as is known in the art.", "Should the presented access code pass a checksum validation, the process may continue, otherwise Wi-Fi access may be denied.", "In another embodiment, the vending machine and/or remote device or computer compares the access code provided by the customer to one or more access codes stored in a local or remote database.", "If the access code matches a (valid) code in the database, the process may continue.", "In one or more embodiments, access codes may be determined to be valid if there is sufficient value remaining in an associated account or database record (e.g., thirty (30) minutes of Wi-Fi access time remaining).", "In one or more embodiments, validating an access code may comprise checking a username and/or password against a database of valid usernames and/or passwords, in an manner known in the art.", "According to some embodiments, the method 500 may continue, such as in the case that an appropriate access code is received and/or validated, by establishing a communication session between a device associated with the customer and a remote network device.", "As described herein, for example, the customer may be provided with Wi-Fi access via the vending machine (and/or such access may be facilitated and/or initiated by the vending machine).", "It should be noted that while the term “Wi-Fi” is used throughout this disclosure to generally describe the network access provided to customers, any form, type, and/or configuration of network access may be provided.", "In other words, the term “Wi-Fi”, while generally implicating a specific protocol and/or type of wireless connectivity, is used herein to refer generally to any type of network, including wired networks.", "In some embodiments, other processes may also or alternatively be included in either of the methods 400, 500.According to some embodiments for example, the vending machine and/or remote computer or device may determine a price to charge a customer for one or more of network access and a physical product.", "In one or more embodiments, the price to be charged is dependent on a customer's status.", "Further, in one or more embodiments, the price to be charged is dependent on a customer's amount of network usage.", "Further still in one or more embodiments, the price to be charged is based on the identity, sales status and/or inventory status of one or more products, including a product selected by a customer.", "For example, network (e.g., Wi-Fi Internet) access may be priced lower if a customer selects a higher margin snack product.", "Or, network access may be “free” if a customer selects a Coca-Cola® product.", "By way of another example, network access may be free if current inventory of one or more items is above or below a certain threshold.", "Further network access may be free if sales volume of one or more products is above or below a certain threshold.", "According to one or more embodiments, pricing may be based in whole or part on the amount of data (e.g., in bytes) downloaded to or uploaded from a customer device or vending machine.", "In embodiments where the price is determined prior to the customer's purchase and/or request for access, the price may accompany any offer for network access that is provided to the customer.", "A.", "EXAMPLES Some embodiments will now be described via exemplary implementations.", "Example 1 In a first example, a customer may approach the vending machine (e.g., come within proximity thereto).", "The vending machine may then output, via an LCD display and/or other output device for example, an offer reading “Have a Bluetooth™ enabled cell phone?", "Get 10 minutes of Voice-over-IP (VoIP) with any snack purchase.” The customer may then, according to some embodiments, depresses a “YES” button (not shown) associated with the vending machine, to indicate a desire to accept the offer.", "In some embodiments, the vending machine may then instruct the customer to purchase a snack (and/or other product from the vending machine).", "Upon depositing cash and/or coin (and/or otherwise providing payment), the customer may then select one or more desired snack items, which may then be dispensed by the vending machine.", "According to some embodiments, the snack item may indicate an access code.", "An indication of an access code may be affixed to the snack item's packaging via a sticker, for example.", "The vending machine may then wirelessly connect, via Bluetooth™ protocol for example, with customer's cellular phone.", "In some embodiments, the customer then enters, into cell phone's keypad, the alphanumeric access code printed on sticker affixed to snack package.", "The customer's cell phone may then wirelessly transmit the access code to the vending machine, causing the vending machine to receive the access code.", "The vending machine may then, according to some embodiments, validate the access code by comparing received access code to codes stored in a database.", "The vending machine may then connect with a VoIP service provider server, and permit the customer to access the VoIP service for ten (10) minutes via the customer's cell phone.", "The customer can either dial phone number using cell phone or dial the number through a vending machine interface.", "Example 2 (1) Customer approaches vending machine.", "(2) Static (painted) sign on vending machine reads: “WiFi access just $5 for 30 minutes.", "Enter code A99 and deposit $5 or swipe credit card.” (3) Customer enters code A99 on vending machine's keypad and swipes credit card.", "(4) Vending machine processes credit card payment.", "(5) Vending machine prints access code with receipt printer and dispenses printed receipt.", "(6) Vending machine wirelessly connects with customer's personal computer.", "(7) Customer enters access code into personal computer (when prompted).", "(8) Customer's personal computer wirelessly transmits access code to vending machine.", "(9) Vending machine receives access code.", "(10) Vending machine validates access code by comparing received access code to codes stored in a database.", "(11) Vending machine connects with Internet Service Provider server.", "(12) Vending machine permits customer to access Internet for 30 minutes via his personal computer.", "Example 3 (1) Customer approaches vending machine.", "(2) Static (painted) sign on vending machine reads: “WiFi access just $5 for 30 minutes.” (3) Vending machine wirelessly connects with customer's personal computer.", "(4) Customer is prompted on computer screen for credit card number.", "(5) Customer enters credit card number, which is transmitted to vending machine.", "(6) Vending machine processes credit card payment.", "(7) Vending machine connects with Internet Service Provider server.", "(8) Vending machine permits customer to access Internet for 30 minutes via his personal computer.", "B. Alternate Embodiments According to an embodiment, access codes may be generated and printed access code onto labels.", "Such labels may be individually detachable (e.g., detachable from a plastic substrate to which the labels are adhesively attached) and attachable to cans/bottles and other items that are dispensable from a vending machine.", "For example, a plurality of access codes may be generated (e.g., as described herein).", "A number of the generated access codes may be printed onto a corresponding number of labels (e.g., blank white labels) which are disposed on an 8½″×11″ sheet of specialized label substrate, such as those sold by Avery-Dennison Corp. of Pasadena, Calif. For example, one appropriate product sold by Avery-Dennison Corp. is the Avery® Label 5160, which includes on each sheet thirty 2.625″×1″ address labels.", "Each such label is white with permanent adhesive and printable by both laser and inkjet printers.", "Accordingly, such a sheet of labels may be fed into a suitable printer, and the printer is driven by appropriate software (e.g., a word processor that generates documents to be printed on the label sheet) to print access codes onto the labels.", "It will be apparent to one of ordinary skill in the art that labels of any shape or configuration may be used.", "Besides labels that may be printed by printers such as laser printers and ink jet printers, a variety of other known devices may print labels onto different substrates.", "For example, the Avery® 9100 Personal Label Printer may be employed to print labels and/or peel labels before they are dispensed.", "Labels are typically adhesively attached to a substrate (e.g., a plastic substrate) and the labels may be detached therefrom by, e.g., peeling the label from the substrate.", "Labels may be peeled by hand, or with the assistance of known apparatus such as label dispensers (e.g., the Avery® Quick Peel™ Automatic Label Peeler, Avery® 6216 Multi-Purpose Label Dispenser).", "Labels which are printed with access codes are detached and applied to products which are dispensable by the vending machine, e.g., during the restocking of the vending machine.", "In one embodiment, the labels are applied to the “back” of products that are visible from outside the vending machine, thereby preventing the label (and codes thereon) to be seen by a person who has not purchased the product that bears the label.", "In one embodiment the printed labels are obscured by, e.g., another label detachably affixed to the label that bears the access code.", "Thus, until the upper label is removed the access code on the lower label is not visible.", "In one embodiment, labels that bear access codes are applied or applicable to products in a manner which (a) does not render the access codes visible to “viewers” who have not acquired the product (e.g., customers waiting at the vending machine), and/or (b) minimizes the risk that the vending machine stocker will simply take the access codes.", "In an embodiment, after an access code is used (e.g., to gain access to a WiFi network for a period of time through a vending machine), various information regarding such use may be recorded (e.g., in a database that is accessible to vending machines).", "For example, after an access code is used, any or all of the following may be stored: (i) the vending machine(s) at which the access code was used, (ii) the date and time the use of the access code was initiated, (iii) the date and time the use of the access code was discontinued.", "In addition, since the vending machine at which the access code was acquired can be stored (e.g., a corresponding vending machine is assigned to a code when the access code is generated, when the code is applied to a product), the correlation between location of acquisition and location of use of access codes may be determined.", "Such stored information may be used to generate reports that indicate, e.g., access code trends by town, state, or other geographic region.", "Since the time of acquisition of the access code can be stored (e.g., a corresponding vending machine is assigned to a code when the access code is generated, and the vending machine determines when a product bearing the code was sold), the delay between time of acquisition and time of use of access codes may be determined.", "Such stored information may be used to generate reports that indicate, e.g., access code trends by date, season, time, and/or by town, state, or other geographic region.", "According to one or more embodiments, network access purchased from a vending machine may be accessed through other means, independent of a vending machine.", "For example, in an embodiment, a customer purchases network access from a vending machine, receives an access code, and then access a communications network using a computer at his or her house.", "In this manner, purchased network access can be, in a sense, “portable”.", "Further, in this manner, network access purchased at a vending machine with cash can enable a customer to utilize a communications network anonymously.", "According to one or more embodiments, a vending machine may serve as a “repeater” of a wireless access point within its vicinity.", "Thus, the wireless access point may communicate with a vending machine, which itself serves as a wireless access point, thereby broadening the range of service.", "According to one or more embodiments, access codes may be “renewed” by customers.", "Customer may renew access codes by purchasing one or more items from a vending machine.", "According to one or more embodiments, customers may earn access to a communications network (e.g., earn “minutes”) by purchasing one or more physical products from a vending machine.", "Thus, network access can be rewarded as a premium to vending machine customers who purchase a threshold number of products.", "According to one or more embodiments, once a customer has transacted with a vending machine through a customer device, the vending machine may store, in a memory, an identifier associate with the customer device (e.g., a serial number, a software license number, a “cookie” file) so that the vending machine can identify the customer upon subsequent visits to the vicinity of the vending machine.", "In this manner, the vending machine may track purchase behavior, etc.", "V. Rules of Interpretation Numerous embodiments are described in this patent application, and are presented for illustrative purposes only.", "The described embodiments are not, and are not intended to be, limiting in any sense.", "The presently disclosed invention(s) are widely applicable to numerous embodiments, as is readily apparent from the disclosure.", "One of ordinary skill in the art will recognize that the disclosed invention(s) may be practiced with various modifications and alterations, such as structural, logical, software, and electrical modifications.", "Although particular features of the disclosed invention(s) may be described with reference to one or more particular embodiments and/or drawings, it should be understood that such features are not limited to usage in the one or more particular embodiments or drawings with reference to which they are described, unless expressly specified otherwise.", "The present disclosure is neither a literal description of all embodiments of the invention nor a listing of features of the invention that must be present in all embodiments.", "Neither the Title (set forth at the beginning of the first page of this patent application) nor the Abstract (set forth at the end of this patent application) is to be taken as limiting in any way as the scope of the disclosed invention(s).", "The term “product” means any machine, manufacture and/or composition of matter as contemplated by 35 U.S.C.", "§ 101, unless expressly specified otherwise.", "The terms “an embodiment”, “embodiment”, “embodiments”, “the embodiment”, “the embodiments”, “one or more embodiments”, “some embodiments”, “one embodiment” and the like mean “one or more (but not all) disclosed embodiments”, unless expressly specified otherwise.", "A reference to “another embodiment” in describing an embodiment does not imply that the referenced embodiment is mutually exclusive with another embodiment (e.g., an embodiment described before the referenced embodiment), unless expressly specified otherwise.", "The terms “including”, “comprising” and variations thereof mean “including but not limited to”, unless expressly specified otherwise.", "The terms “a”, “an” and “the” mean “one or more”, unless expressly specified otherwise.", "The term “plurality” means “two or more”, unless expressly specified otherwise.", "The term “herein” means “in the present application, including anything which may be incorporated by reference”, unless expressly specified otherwise.", "The phrase “at least one of”, when such phrase modifies a plurality of things (such as an enumerated list of things) means any combination of one or more of those things, unless expressly specified otherwise.", "For example, the phrase at least one of a widget, a car and a wheel means either (i) a widget, (ii) a car, (iii) a wheel, (iv) a widget and a car, (v) a widget and a wheel, (vi) a car and a wheel, or (vii) a widget, a car and a wheel.", "The phrase “based on” does not mean “based only on”, unless expressly specified otherwise.", "In other words, the phrase “based on” describes both “based only on” and “based at least on”.", "The term “whereby” is used herein only to precede a clause or other set of words that express only the intended result, objective or consequence of something that is previously and explicitly recited.", "Thus, when the term “whereby” is used in a claim, the clause or other words that the term “whereby” modifies do not establish specific further limitations of the claim or otherwise restricts the meaning or scope of the claim.", "Where a limitation of a first claim would cover one of a feature as well as more than one of a feature (e.g., a limitation such as “at least one widget” covers one widget as well as more than one widget), and where in a second claim that depends on the first claim, the second claim uses a definite article “the” to refer to the limitation (e.g., “the widget”), this does not imply that the first claim covers only one of the feature, and this does not imply that the second claim covers only one of the feature (e.g., “the widget” can cover both one widget and more than one widget).", "Each process (whether called a method, algorithm or otherwise) inherently includes one or more steps, and therefore all references to a “step” or “steps” of a process have an inherent antecedent basis in the mere recitation of the term ‘process’ or a like term.", "Accordingly, any reference in a claim to a ‘step’ or ‘steps’ of a process has sufficient antecedent basis.", "When an ordinal number (such as “first”, “second”, “third” and so on) is used as an adjective before a term, that ordinal number is used (unless expressly specified otherwise) merely to indicate a particular feature, such as to distinguish that particular feature from another feature that is described by the same term or by a similar term.", "For example, a “first widget” may be so named merely to distinguish it from, e.g., a “second widget”.", "Thus, the mere usage of the ordinal numbers “first” and “second” before the term “widget” does not indicate any other relationship between the two widgets, and likewise does not indicate any other characteristics of either or both widgets.", "For example, the mere usage of the ordinal numbers “first” and “second” before the term “widget” (1) does not indicate that either widget comes before or after any other in order or location; (2) does not indicate that either widget occurs or acts before or after any other in time; and (3) does not indicate that either widget ranks above or below any other, as in importance or quality.", "In addition, the mere usage of ordinal numbers does not define a numerical limit to the features identified with the ordinal numbers.", "For example, the mere usage of the ordinal numbers “first” and “second” before the term “widget” does not indicate that there must be no more than two widgets.", "When a single device or article is described herein, more than one device or article (whether or not they cooperate) may alternatively be used in place of the single device or article that is described.", "Accordingly, the functionality that is described as being possessed by a device may alternatively be possessed by more than one device or article (whether or not they cooperate).", "Similarly, where more than one device or article is described herein (whether or not they cooperate), a single device or article may alternatively be used in place of the more than one device or article that is described.", "For example, a plurality of computer-based devices may be substituted with a single computer-based device.", "Accordingly, the various functionality that is described as being possessed by more than one device or article may alternatively be possessed by a single device or article.", "The functionality and/or the features of a single device that is described may be alternatively embodied by one or more other devices that are described but are not explicitly described as having such functionality and/or features.", "Thus, other embodiments need not include the described device itself, but rather can include the one or more other devices which would, in those other embodiments, have such functionality/features.", "Devices that are in communication with each other need not be in continuous communication with each other, unless expressly specified otherwise.", "On the contrary, such devices need only transmit to each other as necessary or desirable, and may actually refrain from exchanging data most of the time.", "For example, a machine in communication with another machine via the Internet may not transmit data to the other machine for weeks at a time.", "In addition, devices that are in communication with each other may communicate directly or indirectly through one or more intermediaries.", "A description of an embodiment with several components or features does not imply that all or even any of such components and/or features are required.", "On the contrary, a variety of optional components are described to illustrate the wide variety of possible embodiments of the present invention(s).", "Unless otherwise specified explicitly, no component and/or feature is essential or required.", "Further, although process steps, algorithms or the like may be described in a sequential order, such processes may be configured to work in different orders.", "In other words, any sequence or order of steps that may be explicitly described does not necessarily indicate a requirement that the steps be performed in that order.", "The steps of processes described herein may be performed in any order practical.", "Further, some steps may be performed simultaneously despite being described or implied as occurring non-simultaneously (e.g., because one step is described after the other step).", "Moreover, the illustration of a process by its depiction in a drawing does not imply that the illustrated process is exclusive of other variations and modifications thereto, does not imply that the illustrated process or any of its steps are necessary to the invention, and does not imply that the illustrated process is preferred.", "Although a process may be described as including a plurality of steps, that does not indicate that all or even any of the steps are essential or required.", "Various other embodiments within the scope of the described invention(s) include other processes that omit some or all of the described steps.", "Unless otherwise specified explicitly, no step is essential or required.", "Although a product may be described as including a plurality of components, aspects, qualities, characteristics and/or features, that does not indicate that all of the plurality are essential or required.", "Various other embodiments within the scope of the described invention(s) include other products that omit some or all of the described plurality.", "An enumerated list of items (which may or may not be numbered) does not imply that any or all of the items are mutually exclusive, unless expressly specified otherwise.", "Likewise, an enumerated list of items (which may or may not be numbered) does not imply that any or all of the items are comprehensive of any category, unless expressly specified otherwise.", "For example, the enumerated list “a computer, a laptop, a PDA” does not imply that any or all of the three items of that list are mutually exclusive and does not imply that any or all of the three items of that list are comprehensive of any category.", "Headings of sections provided in this patent application and the title of this patent application are for convenience only, and are not to be taken as limiting the disclosure in any way.", "“Determining” something can be performed in a variety of manners and therefore the term “determining” (and like terms) includes calculating, computing, deriving, looking up (e.g., in a table, database or data structure), ascertaining and the like.", "It will be readily apparent that the various methods and algorithms described herein may be implemented by, e.g., appropriately programmed general purpose computers and computing devices.", "Typically a processor (e.g., one or more microprocessors) will receive instructions from a memory or like device, and execute those instructions, thereby performing one or more processes defined by those instructions.", "Further, programs that implement such methods and algorithms may be stored and transmitted using a variety of media (e.g., computer readable media) in a number of manners.", "In some embodiments, hard-wired circuitry or custom hardware may be used in place of, or in combination with, software instructions for implementation of the processes of various embodiments.", "Thus, embodiments are not limited to any specific combination of hardware and software A “processor” means any one or more microprocessors, CPU devices, computing devices, microcontrollers, digital signal processors, or like devices.", "The term “computer-readable medium” refers to any medium that participates in providing data (e.g., instructions) that may be read by a computer, a processor or a like device.", "Such a medium may take many forms, including but not limited to, non-volatile media, volatile media, and transmission media.", "Non-volatile media include, for example, optical or magnetic disks and other persistent memory.", "Volatile media include DRAM, which typically constitutes the main memory.", "Transmission media include coaxial cables, copper wire and fiber optics, including the wires that comprise a system bus coupled to the processor.", "Transmission media may include or convey acoustic waves, light waves and electromagnetic emissions, such as those generated during RF and IR data communications.", "Common forms of computer-readable media include, for example, a floppy disk, a flexible disk, hard disk, magnetic tape, any other magnetic medium, a CD-ROM, DVD, any other optical medium, punch cards, paper tape, any other physical medium with patterns of holes, a RAM, a PROM, an EPROM, a FLASH-EEPROM, any other memory chip or cartridge, a carrier wave as described hereinafter, or any other medium from which a computer can read.", "Various forms of computer readable media may be involved in carrying sequences of instructions to a processor.", "For example, sequences of instruction (i) may be delivered from RAM to a processor, (ii) may be carried over a wireless transmission medium, and/or (iii) may be formatted according to numerous formats, standards or protocols, such as Bluetooth™, TDMA, CDMA, 3G.", "Where databases are described, it will be understood by one of ordinary skill in the art that (i) alternative database structures to those described may be readily employed, and (ii) other memory structures besides databases may be readily employed.", "Any illustrations or descriptions of any sample databases presented herein are illustrative arrangements for stored representations of information.", "Any number of other arrangements may be employed besides those suggested by, e.g., tables illustrated in drawings or elsewhere.", "Similarly, any illustrated entries of the databases represent exemplary information only; one of ordinary skill in the art will understand that the number and content of the entries can be different from those described herein.", "Further, despite any depiction of the databases as tables, other formats (including relational databases, object-based models and/or distributed databases) could be used to store and manipulate the data types described herein.", "Likewise, object methods or behaviors of a database can be used to implement various processes, such as the described herein.", "In addition, the databases may, in a known manner, be stored locally or remotely from a device that accesses data in such a database.", "The present invention can be configured to work in a network environment including a computer that is in communication, via a communications network, with one or more devices.", "The computer may communicate with the devices directly or indirectly, via a wired or wireless medium such as the Internet, LAN, WAN or Ethernet, Token Ring, or via any appropriate communications means or combination of communications means.", "Each of the devices may comprise computers, such as those based on the Intel® Pentium® or Centrino™ processor, that are adapted to communicate with the computer.", "Any number and type of machines may be in communication with the computer.", "The present disclosure provides, to one of ordinary skill in the art, an enabling description of several embodiments and/or inventions.", "Some of these embodiments and/or inventions may not be claimed in the present application, but may nevertheless be claimed in one or more continuing applications that claim the benefit of priority of the present application.", "Applicants intend to file additional applications to pursue patents for subject matter that has been disclosed and enabled but not claimed in the present application." ] ]
Patent_15874256
[ [ "SHUNT SYSTEMS AND METHODS FOR REMOVING EXCESS CEREBROSPINAL FLUID", "A shunt device for directing fluid from a human head, and methods thereof are provided herein.", "The device can be mounted at a skull and include a first catheter that extends into a portion of the head such as a lateral ventricle.", "The first catheter can covey fluid through, and past a valve to a shunt body.", "The shunt body can include openings, allowing the fluid to reenter the head, for example at the subarachnoid space.", "The shunt body can also include other openings that can be associated with a second catheter.", "Fluid can thus also be conveyed out of the body or to a subgaleal pocket." ], [ "1.A method of removing excess cerebrospinal fluid, the method comprising: receiving cerebrospinal fluid from an intracranial region; conveying the cerebrospinal fluid to a chamber mounted at a skull; conveying the cerebrospinal fluid from the chamber to a subarachnoid space of the brain when pressure in the subarachnoid space is not excessive; and conveying the cerebrospinal fluid from the chamber to a subgaleal pocket when the pressure in the subarachnoid space is excessive, wherein the method is performed continuously over at least a week without surgical interference inside the skull.", "2.The method of claim 1, further comprising draining the cerebrospinal fluid from the subgaleal pocket.", "3.The method of claim 1, further comprising hindering a flow of cerebrospinal fluid back into the intracranial region with a valve.", "4.The method of claim 1, wherein the method is performed continuously over at least a month without surgical interference inside the skull.", "5.The method of claim 1, wherein the method is performed continuously over at least a year without surgical interference inside the skull.", "6.The method of claim 1, further comprising the step of determining that larger bodies have collected inside the chamber.", "7.The method of claim 6, further comprising the step of injecting a saline solution into the chamber while mounted at the skull.", "8.The method of claim 7, wherein the step of injecting is done through a needle.", "9.The method of claim 7, wherein the step of injecting is performed at a pressure sufficient to flush larger bodies out of the chamber.", "10.The method of claim 1, further comprising the step of pumping a dome which forms at least a part of the chamber.", "11.The method of claim 1, further comprising conveying the cerebrospinal fluid from the chamber to both the subarachnoid space and the subgaleal pocket simultaneously.", "12.A method of removing excess cerebrospinal fluid, the method comprising: receiving cerebrospinal fluid from an intracranial region; conveying the cerebrospinal fluid to a chamber mounted at a skull; and conveying the cerebrospinal fluid from the chamber simultaneously to a space near an interior of the skull and to a space external from the skull, wherein the method is performed continuously over at least a week without surgical interference inside the skull.", "13.The method of claim 12, further comprising hindering a flow of cerebrospinal fluid back into the intracranial region with a valve.", "14.The method of claim 12, wherein the method is performed continuously over at least a month without surgical interference inside the skull.", "15.The method of claim 12, wherein the method is performed continuously over at least a year without surgical interference inside the skull.", "16.The method of claim 12, further comprising the step of determining that larger bodies have collected inside the chamber.", "17.The method of claim 16, further comprising the step of injecting a saline solution into the chamber while mounted at the skull.", "18.The method of claim 17, wherein the step of injecting is done through a needle.", "19.The method of claim 17, wherein the step of injecting is performed at a pressure sufficient to flush larger bodies out of the chamber.", "20.A method of removing excess cerebrospinal fluid, the method comprising: creating a hole in a skull; inserting a probe into a hole in a catheter of a shunt device; pulling the first catheter into a desired position within the skull using the probe, such that cerebrospinal fluid can flow through the first catheter into the shunt device; and mounting the shunt body into a hole in the skull while the first catheter is in the desired position.", "21.The method of claim 20, further comprising inserting a needle into the shunt device and injecting a saline solution into the shunt device." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>The shunt systems described herein can be used in the human brain to treat hydrocephalus, and are described in that context herein.", "However, the shunt systems can also be used in other contexts.", "Similarly, although the shunt systems are described as conveying cerebrospinal fluid, they can also be used to convey other fluids such as blood, or medical treatments, and they may have veterinary or other commercial uses.", "As shown in FIG.", "1 , a shunt 1 can be implanted into a human head 10 (or more specifically, a human brain).", "The shunt 1 can include a first catheter 20 extending into a lateral ventricle 12 , although the shunt can be used in other contexts.", "The first catheter 20 can thus conduct fluids, such as cerebrospinal fluid, from the ventricle 12 to a shunt body 30 .", "The shunt body 30 can then allow this fluid to either be conveyed into the subarachnoid space 14 or be diverted to a subgaleal pocket 16 .", "The subgaleal pocket 16 is typically bounded between the skull and the skin of the head, the skin not shown in FIG.", "1 .", "Cerebrospinal fluid that is reintroduced into the subarachnoid space 14 can then recirculate throughout the head 10 (within the skull), promoting natural flows of the cerebrospinal fluid.", "Excess fluid can also exit to the subgaleal pocket 16 , from which it can be reabsorbed into the body's subgaleal pocket or be removed from the body with a needle or other device.", "The shunt 1 can have two flanges integrated into the design to secure the device in a hole in the skull.", "The reliable fixation can seal the hole from any leakage.", "The present application contemplates various shunt devices that can perform these functions.", "For example a shunt device for removing excess cerebrospinal fluid in a human head, the shunt device can include a first catheter, a shunt body, and a second catheter.", "The first catheter can include a first lumen and at least one first catheter opening substantially at a distal end of the first catheter.", "The shunt body can be attached to the first catheter at a proximal end of the first catheter.", "The shunt body can also include a chamber in communication with the first lumen, a mount, and at least one chamber opening.", "The mount can be configured to position the shunt body in a human skull, the mount dividing the shunt body into an intracranial portion and an extracranial portion when positioned in the skull.", "The first catheter can extend from the intracranial portion at the proximal end of the first catheter.", "The at least one chamber opening can be on the intracranial portion and in communication with the chamber such that fluid entering the chamber from the first catheter can simultaneously exit the chamber through the at least one chamber opening.", "The second catheter can be attached to the shunt body in the extracranial portion.", "The second catheter can also include a second lumen in communication with the chamber such that fluid entering the chamber from the first catheter can exit the chamber through the second catheter.", "In a further, embodiment, a shunt device for removing excess cerebrospinal fluid in a human head can include a first catheter and a shunt body.", "The first catheter can include a first lumen and at least one first catheter opening substantially at a distal end of the first catheter.", "The shunt body can attach to the first catheter at a proximal end, and can include a chamber in communication with the first lumen, one or more flanges, at least one first chamber opening, and at least one second chamber opening.", "The one or more flanges can be configured to mount the shunt body to a human skull, dividing the shunt body into an intracranial portion and an extracranial portion when mounted to the skull.", "The first catheter can also extend from the intracranial portion at the proximal end of the first catheter.", "The at least one first chamber opening can be in the intracranial portion and in communication with the chamber such that fluid entering the chamber from the first catheter can simultaneously exit the chamber through the at least one first chamber opening.", "The at least one second chamber opening can be in the extracranial portion and in communication with the chamber such that fluid entering the chamber from the first catheter can exit the chamber through the at least one second chamber opening.", "In a further embodiment, a method of removing excess cerebrospinal fluid can be provided.", "A hole in a skull can be created.", "A probe can be inserted into a hole in a catheter of a shunt device, and the first catheter can be pulled into a desired position within the skull using the probe, such that cerebrospinal fluid can flow through the first catheter into the shunt device.", "The shunt body can then mount into a hole in the skull while the first catheter is in the desired position.", "In a further embodiment, a method of removing excess cerebrospinal fluid can be provided.", "Cerebrospinal fluid from an intracranial region can be received, and conveyed to a chamber mounted at a skull.", "The fluid can then be conveyed from the chamber to a subarachnoid space of the brain when pressure in the subarachnoid space is not excessive.", "The fluid can also be conveyed from the chamber to a subgaleal pocket when the pressure in the subarachnoid space is excessive.", "The method can be performed continuously over at least a week without surgical interference inside the skull." ], [ "INCORPORATION BY REFERENCE TO ANY PRIORITY APPLICATIONS This application claims priority benefit under 35 U.S.C.", "§ 119(e) to U.S. patent application Ser.", "No.", "15/698,278 filed 7 Sep. 2017 entitled “SHUNT SYSTEMS AND METHODS FOR REMOVING EXCESS CEREBROSPINAL FLUID”, which is a divisional application, and U.S.", "Provisional Patent Application Ser.", "No.", "62/393,563 filed 12 Sep. 2016 entitled “STENT SYSTEM FOR REMOVING EXCESS CEREBROSPINAL FLUID”, the entirety of each hereby expressly incorporated by reference herein.", "BACKGROUND Field The embodiments herein relate generally to shunt systems, particularly for removing excess cerebrospinal fluid.", "Description of the Related Art Shunt systems can be used in a variety of circumstances.", "For example, a patient with hydrocephalus experiences excess cerebrospinal fluid accumulating in the brain and causing high intracranial pressure.", "Such accumulations can occur when the natural movement of cerebrospinal fluid is blocked or excessive pressure results from injury or other causes.", "A shunt system can be used to allow the fluid to flow out of the impacted region, thus reducing the intracranial pressure.", "SUMMARY The shunt systems described herein can be used in the human brain to treat hydrocephalus, and are described in that context herein.", "However, the shunt systems can also be used in other contexts.", "Similarly, although the shunt systems are described as conveying cerebrospinal fluid, they can also be used to convey other fluids such as blood, or medical treatments, and they may have veterinary or other commercial uses.", "As shown in FIG.", "1, a shunt 1 can be implanted into a human head 10 (or more specifically, a human brain).", "The shunt 1 can include a first catheter 20 extending into a lateral ventricle 12, although the shunt can be used in other contexts.", "The first catheter 20 can thus conduct fluids, such as cerebrospinal fluid, from the ventricle 12 to a shunt body 30.The shunt body 30 can then allow this fluid to either be conveyed into the subarachnoid space 14 or be diverted to a subgaleal pocket 16.The subgaleal pocket 16 is typically bounded between the skull and the skin of the head, the skin not shown in FIG.", "1.Cerebrospinal fluid that is reintroduced into the subarachnoid space 14 can then recirculate throughout the head 10 (within the skull), promoting natural flows of the cerebrospinal fluid.", "Excess fluid can also exit to the subgaleal pocket 16, from which it can be reabsorbed into the body's subgaleal pocket or be removed from the body with a needle or other device.", "The shunt 1 can have two flanges integrated into the design to secure the device in a hole in the skull.", "The reliable fixation can seal the hole from any leakage.", "The present application contemplates various shunt devices that can perform these functions.", "For example a shunt device for removing excess cerebrospinal fluid in a human head, the shunt device can include a first catheter, a shunt body, and a second catheter.", "The first catheter can include a first lumen and at least one first catheter opening substantially at a distal end of the first catheter.", "The shunt body can be attached to the first catheter at a proximal end of the first catheter.", "The shunt body can also include a chamber in communication with the first lumen, a mount, and at least one chamber opening.", "The mount can be configured to position the shunt body in a human skull, the mount dividing the shunt body into an intracranial portion and an extracranial portion when positioned in the skull.", "The first catheter can extend from the intracranial portion at the proximal end of the first catheter.", "The at least one chamber opening can be on the intracranial portion and in communication with the chamber such that fluid entering the chamber from the first catheter can simultaneously exit the chamber through the at least one chamber opening.", "The second catheter can be attached to the shunt body in the extracranial portion.", "The second catheter can also include a second lumen in communication with the chamber such that fluid entering the chamber from the first catheter can exit the chamber through the second catheter.", "In a further, embodiment, a shunt device for removing excess cerebrospinal fluid in a human head can include a first catheter and a shunt body.", "The first catheter can include a first lumen and at least one first catheter opening substantially at a distal end of the first catheter.", "The shunt body can attach to the first catheter at a proximal end, and can include a chamber in communication with the first lumen, one or more flanges, at least one first chamber opening, and at least one second chamber opening.", "The one or more flanges can be configured to mount the shunt body to a human skull, dividing the shunt body into an intracranial portion and an extracranial portion when mounted to the skull.", "The first catheter can also extend from the intracranial portion at the proximal end of the first catheter.", "The at least one first chamber opening can be in the intracranial portion and in communication with the chamber such that fluid entering the chamber from the first catheter can simultaneously exit the chamber through the at least one first chamber opening.", "The at least one second chamber opening can be in the extracranial portion and in communication with the chamber such that fluid entering the chamber from the first catheter can exit the chamber through the at least one second chamber opening.", "In a further embodiment, a method of removing excess cerebrospinal fluid can be provided.", "A hole in a skull can be created.", "A probe can be inserted into a hole in a catheter of a shunt device, and the first catheter can be pulled into a desired position within the skull using the probe, such that cerebrospinal fluid can flow through the first catheter into the shunt device.", "The shunt body can then mount into a hole in the skull while the first catheter is in the desired position.", "In a further embodiment, a method of removing excess cerebrospinal fluid can be provided.", "Cerebrospinal fluid from an intracranial region can be received, and conveyed to a chamber mounted at a skull.", "The fluid can then be conveyed from the chamber to a subarachnoid space of the brain when pressure in the subarachnoid space is not excessive.", "The fluid can also be conveyed from the chamber to a subgaleal pocket when the pressure in the subarachnoid space is excessive.", "The method can be performed continuously over at least a week without surgical interference inside the skull.", "BRIEF DESCRIPTION OF THE DRAWINGS Further objects, features and advantages will become apparent from the following detailed description taken in conjunction with the accompanying figures showing illustrative embodiments, in which: FIG.", "1 is a cross-sectional view of a human head with an implanted shunt device.", "FIG.", "2 is a perspective view of a shunt device.", "FIG.", "3 is a cross-sectional view of the shunt device of FIG.", "2.FIG.", "4 is a bottom view of the shunt device of FIG.", "2.FIG.", "5 is a side view of the shunt device of FIG.", "2.FIG.", "6 is a cross-sectional view of the shunt device of FIG.", "2, indicating directions of flow.", "FIG.", "7 is a cross-sectional and exploded view of a shunt device.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS As shown in FIG.", "1, the shunt device 1 can be used to access a region of a head 10 (such as a lateral ventricle 12) and convey fluid (such as cerebrospinal fluid) from that region to another region of the head (such as the subarachnoid space 14) or outside of the head (such as to a subgaleal pocket 16).", "However, it will be understood that the device can be used in other regions of a human body (including pre-mature newborns, mature newborns, children, and adults), or a non-human body (with dimensions adjusted accordingly).", "For example, the device can also be used on other animals such as dogs, cats, cows, horses, sheep, and other pets or livestock (with dimensions adjusted accordingly).", "Further, the device can direct cerebrospinal fluid from other regions in the brain to other parts of the body, such as directing liquid from benign intracranial cysts, and providing a second stage fluid outflow to the peritoneal cavity after integration with a traditional peritoneal shunt.", "The device can also be used to facilitate the purification and sanitation of blood, such as in the context of post-hemorrhagic hydrocephalus in infants, porencephalus, and post-hemorrhagic cysts.", "The device can also be used in the context of post-hemorrhagic arachnoiditis prevention or treatment, such as for the infusion of saline solutions or physiological solutions.", "The device can also be used to direct other fluids, such as blood between different regions of the body.", "As more clearly shown in FIGS.", "2 and 3, the shunt device 1 can include a shunt body 30 with a first catheter 20 extending from the shunt body on a lower side of the device and a second catheter 50 extending from the shunt body on a lateral side of the device (extending generally along the exterior of the head/skull).", "As discussed further herein (and depicted, for example, in FIG.", "1), the shunt device 1 can be mounted within a skull, such that the “lower” side depicted in the figures can be called an intracranial side, or patient-facing side.", "Similarly, a “lateral” or “upper” side of the device can be called an extracranial side of the device, or outer-facing side.", "However, it will be understood that the device can also be provided in other orientations.", "The shunt device 1 can be inserted into a hole in the skull, and be self-sealing inside the hole with flanges (further described below).", "As also further described below, the shunt device 1 can include openings that allow excess fluid to be directed back down, into the skull (such as into a subarachnoid space).", "The first catheter 20 can extend into the head 10, particularly a lateral ventricle 12, although it will be clear that it could also extend into other parts of the head such as into a benign intracranial cyst.", "The first catheter can be formed from silicone (such as medical grade silicone), and be generally flexible to allow a physician to position it in a variety of locations and orientations.", "The first catheter can have a width of at least 1 mm, at least 1.5 mm, or at least 2 mm, and can also be less than 3 mm, less than 4 mm, or less than 5 mm.", "The first catheter can also have a length of at least 30 mm, at least 40 mm, or at least 50 mm, and less than 70 mm, less than 80 mm, or less than 100 mm.", "Dimensions can be further modified, as appropriate for the intended use.", "The first catheter can have a length sufficient to extend from a trepanned hole in the skull to a lateral ventricle.", "The first catheter can also have a lumen with a size of at least 0.5 mm, 1 mm, or 2 mm, and optionally also less than 3 mm or less than 2 mm.", "These sizes can be sufficient to transport cerebrospinal fluid under most conditions.", "As best shown in FIG.", "3, the first catheter 20 can include at least one opening 22 substantially at an end distal from the shunt body 30.FIG.", "3 shows two openings 22, although the catheter can optionally have one opening, more than two openings, four openings, or more than four openings.", "The openings 22 can be substantially at the distal end of the first catheter 20 to allow the conveyance of fluid through nearly the entire length of the first catheter.", "The openings 22 can have a size of at least 0.1 mm, 0.2 mm, or 0.3 mm, sufficient to transport cerebrospinal fluid.", "The openings 22 can also be sufficiently small to avoid the uptake of larger bodies such as blood clots, or choroid plexus, with a size no larger than 0.5 mm.", "Similarly, the distal end of the lumen of the first catheter 20 can optionally be axially closed to prevent the uptake of large bodies that might obstruct the shunt device 1.The openings 22 can optionally be disposed laterally, on a side of the first catheter 20, near the distal end, as shown in FIG.", "3.The first catheter 20 can also include a guide opening 24.The guide opening 24 can be used, as further described below, to guide the first catheter 20 into a desired position, such as within a lateral ventricle 12 or a benign intracranial cyst.", "As shown, the guide opening 24 can optionally be provided below (or distal) from the other openings 22.Further, the guide opening 24 can optionally have a larger size, to receive a guide or probe further described below, or can be the same size as the other openings 22.The first catheter 20 can extend, from its distal end, upwards to its proximal end where it connects to the shunt body 30.The shunt device 1 can also optionally include a valve 40 to allow flow from the first catheter 20 to the shunt body 30, but substantially hinder flow from the shunt body 30 to the first catheter 20.The valve 40 can be a self-closing check valve, a ball check valve, a diaphragm check valve, a petal valve, a swing check valve, or other types of valves.", "Although the valve 40 in FIG.", "3 is depicted as a part of the first catheter 20, it can also be a part of the shunt body 30 (for example, a part of the shunt body floor 36), or be a separate piece connecting the shunt body and the first catheter.", "The valve 40 can be formed from medical silicone.", "The fluid pressure required to open the valve 40 to allow flow into the shunt device 1 (such as from the first catheter 20 to the chamber 38) can be greater than 10 mm of water, or greater than 20 mm of water.", "For example, the pressure can be adapted to the smallest physiological age-related intracranial pressure in people such as premature newborns or adults.", "In other applications, other pressures can be used.", "The lumen of the first catheter 20 can be in communication with the interior of the shunt body 30 (for example, through the optional valve 40).", "As shown in FIG.", "3, the shunt body 30 can define a chamber 38.The chamber 38 can be bounded by a substantially planar floor 36 on an intracranial side of the shunt body 30.The chamber 38 can be also be bounded by a dome 34 on an upper, extracranial side of the shunt body 30.As shown in FIG.", "3, the shunt body 30 can be formed primarily by two pieces (the dome 34 and the floor 36) being joined together.", "However, in other embodiments portions of the shunt body 30 can be formed by a variety of other pieces, such as with additional side walls (further discussed below, regarding FIG.", "7).", "Further, as depicted in FIGS.", "2, 3, and 4, the shunt body 30 can have a generally circular shape in a plane, such as a plane defined by the floor 36, a plane generally perpendicular to the first catheter 20, a plane parallel to the skull or a surface of the body, or a plane defined by one or more flanges 32.As shown in FIG.", "3, the shunt body 30 can include two flanges 32A and 32B.", "The flanges 32A, 32B can extend around a perimeter of the shunt body 30.At least one of the flanges 32A, 32B can be defined by the shunt body floor 36.Similarly, at least one of the flanges 32A, 32B can be defined by the shunt body dome 34.As depicted in FIG.", "3, the lower flange 32B can be defined by the floor 36 and the upper flange 32A can be defined by the dome 34.However, in other embodiments one of the floor 36 or the dome 34 may define two flanges.", "The flanges 32A, 32B can be configured to mount the shunt body 30 within a patient's body.", "For example, the flanges 32 can be configured to receive the edges of a trepanned burr hole in a skull, with the lower flange 32B being within the arachnoid meninx and the upper flange 32A being straightened on the bone edges of the trepanation.", "The flanges 32 can be spaced apart approximately 4.5 mm, between 4 mm and 5 mm, or a skull width.", "Further, the flanges 32 can outwardly extend at least 4 mm from the rest of the shunt body 30.The flanges can also be configured to form a seal between the upper and lower sides of the shunt body 30 when mounted.", "For example, the flanges 32 can extend about the entire perimeter of the shunt body 30 on at least one side, or on both the upper and lower sides.", "The lower portion of the shunt body 30 (such as the floor 36) can include one or more chamber openings 37, as best shown in FIG.", "4.The chamber openings 37 allow flow of fluid within the chamber 38 out of the shunt body 30, downward (for example, toward the subarachnoid space).", "Thus, when the shunt body 30 is implanted within a skull, as discussed above, the fluid can flow from the chamber 38 into the head.", "As shown, eight chamber openings 37 can be provided, although other numbers of openings are also possible.", "The size of each opening can optionally be at least 1 mm or at least 2 mm in diameter, or a size large enough to allow larger bodies that may enter the first catheter (such as clots and fibrin) to exit the chamber 38.The sum of the areas of each opening can optionally be at least 10 mm squared or 20 mm squared.", "Further, the openings 37 can be positioned to allow fluid to flow through the openings from the chamber 38 into the subarachnoid space.", "The upper portion of the shunt body 30 can define a dome 34.The upper portion of the shunt body 30 can provide space for the chamber 38, and thus can optionally have other non-dome shapes.", "The dome 34 (or at least some of the upper portion) can be formed of a material that can be easily penetrated by a needle (such as silicone), such that the chamber 38 can be accessed, as further discussed below.", "The dome 34 can be made of a flexible material, such that it can be pumped to facilitate the flow of fluids through the shunt device 1.For example, compressing the dome 34 can force fluid (and other particles that might clog the device) out through the second catheter 50 or the openings 37.Similarly, releasing the dome 34 can create a suction effect, bringing similar particles and fluid up through the first catheter 20.The shunt body 30 can also include an opening for receiving a second catheter 50, such that the lumen of the second catheter is in communication with the chamber 38.As depicted, the chamber 38 can be disposed in the upper portion of the shunt body 30, above the flanges 32.Thus, when implanted in a skull, the second catheter can extend on an extracranial side of the device, such that fluid from inside the head (such as inside the lateral ventricles and subarachnoid space) can flow from the head, through the first catheter 20 to the chamber 38, and then out of the head through the second catheter 50.As shown in FIG.", "3, the second catheter 50 can have a proximal opening at the chamber 38, and two distal openings 55, both axially at an opposite end from the chamber 38 and laterally, along a side of the second catheter generally near the distal end.", "However, in other embodiments the second catheter 50 can be mounted differently, or have different openings.", "For example, in some embodiments the second catheter 50 can communicate with the chamber 38 from above, instead of from the side.", "Similarly, the second catheter 50 can optionally only have an axial opening at the distal end or only have a lateral opening at the distal end.", "The second catheter 50 can optionally have a size, shape, and material generally similar to those options possible for the first catheter 20.FIG.", "6 depicts various ways fluid can be conveyed through the shunt device 1.As shown, fluid can be received from an intracranial region, through the first catheter 20.This fluid can then be conveyed, for example through the valve 40, into the chamber 38.From the chamber 38, the fluid can either be conveyed back downward through the chamber openings 37, or out through the second catheter 50.The flow's primary direction (through the chamber openings 37 into the subarachnoid space or the second catheter 50 to the subgaleal pocket) can be affected by a variety of factors including the size, shape, and orientation of the openings, fluid pressure at their outlets, and other factors.", "In some embodiments, the chamber openings 37 can define a generally larger area than the lumen of the second catheter 50, such that fluid from the chamber predominantly flows through the chamber openings absent a countervailing pressure.", "The shunt device 1 can be produced in a variety of ways.", "In some embodiments it can be 3D printed as a single piece shunt body 30, with the catheters 20, 50 attached separately.", "The valve 40 can be 3D printed with the body 30, or attached along with the first catheter 20.In other embodiments, the shunt device 1 can be assembled from a larger number of parts that can be welded, glued, or otherwise combined.", "FIG.", "7 depicts an exploded view of a shunt device 101, substantially similar to the shunt device 1, but assembled from a larger number of parts, with similar parts having a corresponding reference number (increased by 100).", "The shunt device 101 can use additional walls 160A, 160B to provide space between flanges 132A, 132B, and between the valve 140 and the floor 136.Other variations on the manufacture of the shunt device 1 are also possible, such as by 3D printing other combinations of the components together as one piece.", "The components of the shunt body 30 can be formed from a variety of materials such as silicone.", "After production, the shunt device 1 can optionally be inserted into a sterilized packaging.", "In some embodiments, the packaging can also include instructions for the use of the device, as further described below.", "For implantation of the shunt device 1 into a patient, a burr hole in the skull can be made, generally matching the shape of the shunt body 30 at a mount such as between the flanges 32.The first catheter 20 can then be guided into a desired region of the head, such as a lateral ventricle 12.The first catheter 20 can be guided by an elongated, blunt probe that inserts into the guide opening 24.Once inserted into the guide opening 24, advancing the probe into the ventricle will similarly pull the first catheter 20 into the same location.", "The probe can then be pulled back, exiting the guide opening 24 while leaving the first catheter 20 behind.", "Cerebrospinal fluid from that location can then be conveyed through the first catheter 20.The shunt body 30, attached to the first catheter 20, can then be mounted into the hole in the skull.", "When the flanges 32 are flexible, the shunt body 30 can be snapped into place within the hole, the skull disposed between the flanges.", "Further, if the hole and the shunt body 30 match sufficiently in size and shape then the shunt body 30 can also seal the hole, preventing any flow of fluid through the hole except through the shunt device 1.The second catheter 50, attached to the shunt body 30, can then be advanced into a desired position outside the skull, but beneath the skin.", "Fluid flowing through the second catheter 50 from the shunt body 30 can then be collected in a subgaleal pocket.", "Alternatively, in some embodiments the second catheter 50 can direct fluid to a location outside the body, or other locations in the body.", "After implantation, the shunt device 1 can receive cerebrospinal fluid from an interior of the head.", "This fluid can enter the chamber 38, substantially at the skull.", "Some of this fluid can then be conveyed back into the subarachnoid space of the head, into a subgaleal pocket, or another location.", "The flow can be determined by a pressure in the subarachnoid space, as well as a pressure in the subgaleal pocket.", "Because the device is implanted in the patient, this conveying of fluid can proceed continuously over extended periods of time, such as a week, a month, a year, or longer.", "No additional surgical interference inside the skull is necessary to continue this conveying of fluid.", "Occasionally, there may be an excessive build-up of fluid in the subgaleal pocket that should be removed.", "In this situation, a needle can access the pocket and remove the fluid.", "At other times, it may be determined that larger bodies have entered the shunt device 1.In this situation, a needle can optionally be used to penetrate the dome 34 (or the upper side of the shunt device 1) and inject fluid into the chamber 38 at a pressure sufficient to flush out the larger bodies.", "If it is desired to flush out the first catheter 20 and a valve 40 is present, the pressure can be sufficient to overcome the valve and through suction induce a flow through the first catheter.", "Alternatively, the needle can be used to force the valve 40 open to allow this back flow.", "The reversed flow of fluid can force any large bodies out through the openings 22, 24, clearing the first catheter 20.The various devices, methods, procedures, and techniques described above provide a number of ways to carry out the invention.", "Of course, it is to be understood that not necessarily all objectives or advantages described may be achieved in accordance with any particular embodiment described herein.", "Also, although the invention has been disclosed in the context of certain embodiments and examples, it will be understood by those skilled in the art that the invention extends beyond the specifically disclosed embodiments to other alternative embodiments and/or uses and obvious modifications and equivalents thereof.", "Accordingly, the invention is not intended to be limited by the specific disclosures of preferred embodiments herein." ] ]
Patent_15874264
[ [ "ENHANCED VIRTUAL FUNCTION CAPABILITIES IN A VIRTUALIZED NETWORK ENVIRONMENT", "The present disclosure is directed to enhanced virtual function capabilities in a virtualized network environment.", "In general, devices may comprise physical and virtualized resources.", "The physical resources may comprise at least a network adaptor that may handle incoming data from a network and outgoing data to the network.", "The virtualized resources may comprise at least one virtual machine (VM) and a corresponding interface.", "The corresponding interface may be one of a physical interface, a virtual interface or a “super” virtual interface.", "The physical interface may provide a first set of capabilities allowing the VM to access (e.g., control) at least the network adaptor.", "The virtual interface may provide a second set of capabilities that is a subset of the first set.", "The super virtual interface may provide a third set of capabilities including the second set of capabilities and at least one additional capability from the first set of capabilities." ], [ "1.A device capable of virtualized operation, comprising: physical resources including at least a virtual function-enabled network adaptor; memory circuitry in which an operating system and virtualized resources are loaded, the virtualized resources including virtual machines and interfaces corresponding to each of the virtual machines, the interfaces including a physical interface, a virtual interface and a super virtual interface; and processing circuitry to at least cause a first virtual machine and a corresponding physical function driver having the physical interface to be loaded into the memory circuitry to control the virtual function-enabled network adaptor, a second virtual machine to be loaded into the memory circuitry as a virtual function driver for the virtual interface and a third virtual machine to be loaded into the memory circuitry as a super function driver for the super virtual interface, wherein the virtual function-enabled network adaptor is configurable to advertise to the operating system a capability list including at least one capability available to the virtual machine through the super virtual interface and unavailable through the virtual interface.", "2.The device of claim 1, wherein the virtual function-enabled network adaptor is configured to operate utilizing single root input/output virtualization.", "3.The device of claim 1, wherein the physical interface is to provide to the corresponding virtual machine a first set of capabilities to control the virtual function-enabled network adaptor.", "4.The device of claim 3, wherein the capabilities include the ability to access at least one register in the device for controlling operation of at least the virtual function-enabled network adaptor.", "5.The device of claim 3, wherein the virtual interface is to provide to the corresponding virtual machine a second set of capabilities that is a subset of the capabilities included in the first set.", "6.The device of claim 5, wherein the super virtual interface is to provide to the corresponding virtual machine a third set of capabilities including the second set of capabilities and at least one additional capability included in the first set.", "7.The device of claim 1, wherein the processing circuitry is to cause a virtual machine manager to be loaded into the memory circuitry.", "8.The device of claim 7, wherein the virtual machine manager is to determine that a virtual machine is to be loaded into the memory circuitry.", "9.The device of claim 8, wherein the virtual machine manager is to determine whether to load a physical interface, virtual interface or super virtual interface.", "10.The device of claim 9, wherein in determining to load the super virtual interface the virtual machine manager is to determine at least one additional capability.", "11.The device of claim 10, wherein in determining the at least one additional capability the virtual machine manager is to determine whether the virtual machine is allowed to access the at least one additional capability based on a security configuration.", "12.A method for virtualized operation, comprising: determining that a virtual machine is to be loaded into memory circuitry in a device including at least a virtual function-enabled network adaptor and an operating system loaded in the memory circuitry; determining at least one of a physical interface, a virtual interface or a super virtual interface to be loaded corresponding to the virtual machine based on a capability list received in the operating system from the virtual function-enabled network adaptor, the capability list including at least one capability available to the virtual machine through the super virtual interface and unavailable through the virtual interface, the physical interface, virtual interface or super virtual interface allowing the virtual machine to access the virtual function-enabled network adaptor; and causing a first virtual machine and a corresponding physical function driver having the physical interface to be loaded into the memory circuitry to control the virtual function-enabled network adaptor, a second virtual machine to be loaded into the memory circuitry as a virtual function driver for the virtual interface and a third virtual machine to be loaded into the memory circuitry as a super function driver for the super virtual interface.", "13.The method of claim 12, wherein the physical interface provides to the corresponding virtual machine a first set of capabilities to control the virtual function-enabled network adaptor.", "14.The method of claim 13, wherein the capabilities include the ability to access at least one register in the device for controlling operation of at least the virtual function-enabled network adaptor.", "15.The method of claim 13, wherein the virtual interface provides to the corresponding virtual machine a second set of capabilities that is a subset of the capabilities included in the first set.", "16.The method of claim 15, wherein the super virtual interface provides to the corresponding virtual machine a third set of capabilities including the second set of capabilities and at least one additional capability included in the first set.", "17.The method of claim 16, further comprising: determining the at least one additional capability when it is determined that a super virtual interface is to be loaded.", "18.The method of claim 17, further comprising: determining whether the virtual machine is allowed to access at least one additional capability based on a security configuration in the device.", "19.At least one machine-readable storage medium having stored thereon, individually or in combination, instructions for virtualized operation that, when executed by one or more processors, cause the one or more processors to: determine that a virtual machine is to be loaded into memory circuitry in a device including at least a virtual function-enabled network adaptor and an operating system loaded in the memory circuitry; determine at least one of a physical interface, a virtual interface or a super virtual interface to be loaded corresponding to the virtual machine based on a capability list received in the operating system from the virtual function-enabled network adaptor, the capability list including at least one capability available to the virtual machine through the super virtual interface and unavailable through the virtual interface, the physical interface, virtual interface or super virtual interface allowing the virtual machine to access a the virtual function-enabled network adaptor; and causing a first virtual machine and a corresponding physical function driver having the physical interface to be loaded into the memory circuitry to control the virtual function-enabled network adaptor, a second virtual machine to be loaded into the memory circuitry as a virtual function driver for the virtual interface and a third virtual machine to be loaded into the memory circuitry as a super function driver for the super virtual interface.", "20.The storage medium of claim 19, wherein the physical interface is to provide to the corresponding virtual machine a first set of capabilities to control the virtual function-enabled network adaptor.", "21.The storage medium of claim 20, wherein the capabilities include the ability to access at least one register in the device for controlling operation of at least the virtual function-enabled network adaptor.", "22.The storage medium of claim 20, wherein the virtual interface is to provide to the corresponding virtual machine a second set of capabilities that is a subset of the capabilities included in the first set.", "23.The storage medium of claim 22, wherein the super virtual interface is to provide to the corresponding virtual machine a third set of capabilities including the second set of capabilities and at least one additional capability included in the first set.", "24.The storage medium of claim 23, further comprising instructions that, when executed by one or more processors, cause the one or more processors to: determine the at least one additional capability when it is determined that a super virtual interface is to be loaded.", "25.The storage medium of claim 24, further comprising instructions that, when executed by one or more processors, cause the one or more processors to: determine whether the virtual machine is allowed to access at least one additional capability based on a security configuration in the device.", "26.A system for virtualized operation, comprising: means for determining that a virtual machine is to be loaded into memory circuitry in a device including at least a virtual function-enabled network adaptor and an operating system loaded in the memory circuitry; means for determining at least one of a physical interface, a virtual interface or a super virtual interface to be loaded corresponding to the virtual machine based on a capability list received in the operating system from the virtual function-enabled network adaptor, the capability list including at least one capability available to the virtual machine through the super virtual interface and unavailable through the virtual interface, the physical interface, virtual interface or super virtual interface allowing the virtual machine to access the virtual function-enabled network adaptor; and means for causing a first virtual machine and a corresponding physical function driver having the physical interface to be loaded into the memory circuitry to control the virtual function-enabled network adaptor, a second virtual machine to be loaded into the memory circuitry as a virtual function driver for the virtual interface and a third virtual machine to be loaded into the memory circuitry as a super function driver for the super virtual interface.", "27.The system of claim 26, wherein the physical interface is to provide to the corresponding virtual machine a first set of capabilities to control the virtual function-enabled network adaptor.", "28.The system of claim 27, wherein the virtual interface is to provide to the corresponding virtual machine a second set of capabilities that is a subset of the capabilities included in the first set.", "29.The system of claim 28, wherein the super virtual interface is to provide to the corresponding virtual machine a third set of capabilities including the second set of capabilities and at least one additional capability included in the first set." ], [ "<SOH> BACKGROUND <EOH>Virtualization may be utilized in a device to subdivide physical processing resources into different “virtual” processing devices.", "Virtual machines (VM) may be loaded into the device to emulate the operation of standalone devices.", "VMs may operate collaboratively to perform a task or individually to perform a variety of different operations.", "For example, in certain virtualization architectures one VM may have access to control physical resources in a device (e.g., a network adapter), while other VMs may be provided with limited control features.", "This approach may be sufficient for cloud computing (e.g., including at least one server accessible via a network such as the Internet) wherein the operational focus may be primarily on data processing and storage.", "However, some applications such as virtual telecommunications company (Telco) networks may employ certain virtual network functions (VNFs) such as, for example, virtualized proxy servers, firewalls, routers, etc.", "The performance of these VNFs may benefit substantially from being able to directly access physical resource and configuration registers.", "Direct access may avoid latency that may be experienced when accessing these configurations via the host operating system (OS), thereby helping promote the use of standard servers within virtual networking environments such as Network Function Virtualization (NFV) or Software Defined Networking (SDN) scenarios." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Features and advantages of various embodiments of the claimed subject matter will become apparent as the following Detailed Description proceeds, and upon reference to the Drawings, wherein like numerals designate like parts, and in which: FIG.", "1 illustrates an example system including enhanced virtual function capabilities in a virtualized network environment in accordance with at least one embodiment of the present disclosure; FIG.", "2 illustrates an example configuration for a device usable in accordance with at least one embodiment of the present disclosure; FIG.", "3 illustrates an example implementation of a system including enhanced virtual function capabilities in a virtualized network environment in accordance with at least one embodiment of the present disclosure; and FIG.", "4 illustrates example operations for virtualized operation in accordance with at least one embodiment of the present disclosure.", "detailed-description description=\"Detailed Description\" end=\"lead\"?", "Although the following Detailed Description will proceed with reference being made to illustrative embodiments, many alternatives, modifications and variations thereof will be apparent to those skilled in the art." ], [ "TECHNICAL FIELD The present disclosure relates to data processing, and more particularly, to a system that may grant enhanced capabilities to virtual functions associated with virtual machines in a device.", "BACKGROUND Virtualization may be utilized in a device to subdivide physical processing resources into different “virtual” processing devices.", "Virtual machines (VM) may be loaded into the device to emulate the operation of standalone devices.", "VMs may operate collaboratively to perform a task or individually to perform a variety of different operations.", "For example, in certain virtualization architectures one VM may have access to control physical resources in a device (e.g., a network adapter), while other VMs may be provided with limited control features.", "This approach may be sufficient for cloud computing (e.g., including at least one server accessible via a network such as the Internet) wherein the operational focus may be primarily on data processing and storage.", "However, some applications such as virtual telecommunications company (Telco) networks may employ certain virtual network functions (VNFs) such as, for example, virtualized proxy servers, firewalls, routers, etc.", "The performance of these VNFs may benefit substantially from being able to directly access physical resource and configuration registers.", "Direct access may avoid latency that may be experienced when accessing these configurations via the host operating system (OS), thereby helping promote the use of standard servers within virtual networking environments such as Network Function Virtualization (NFV) or Software Defined Networking (SDN) scenarios.", "BRIEF DESCRIPTION OF THE DRAWINGS Features and advantages of various embodiments of the claimed subject matter will become apparent as the following Detailed Description proceeds, and upon reference to the Drawings, wherein like numerals designate like parts, and in which: FIG.", "1 illustrates an example system including enhanced virtual function capabilities in a virtualized network environment in accordance with at least one embodiment of the present disclosure; FIG.", "2 illustrates an example configuration for a device usable in accordance with at least one embodiment of the present disclosure; FIG.", "3 illustrates an example implementation of a system including enhanced virtual function capabilities in a virtualized network environment in accordance with at least one embodiment of the present disclosure; and FIG.", "4 illustrates example operations for virtualized operation in accordance with at least one embodiment of the present disclosure.", "Although the following Detailed Description will proceed with reference being made to illustrative embodiments, many alternatives, modifications and variations thereof will be apparent to those skilled in the art.", "DETAILED DESCRIPTION The present disclosure is directed to enhanced virtual function capabilities in a virtualized network environment.", "In general, devices may comprise physical and virtualized resources.", "The physical resources may comprise at least a network adaptor that may handle incoming data from a network and outgoing data to the network.", "The virtualized resources may comprise at least one virtual machine (VM) and a corresponding interface.", "The corresponding interface may be one of a physical interface, a virtual interface or a “super” virtual interface.", "The physical interface may provide a first set of capabilities allowing the VM to access (e.g., control) at least the network adaptor.", "The virtual interface may provide a second set of capabilities that is a subset of the first set.", "The super virtual interface may provide a third set of capabilities including the second set of capabilities and at least one additional capability selected from the first set of capabilities.", "In this manner, the capabilities of the super virtual interface may be customized based on, for example, the specific operations contemplated for the VM.", "A virtual machine manager (e.g., hypervisor) may control when new VMs are loaded and how additional capabilities are granted to the super virtual interface.", "In at least one embodiment, the hypervisor may determine whether a new VM is entitled to an additional capability based on, for example, a device security configuration.", "In at least one embodiment, a device capable of virtualized operation may comprise, for example, at least physical resources, memory circuitry and processing circuitry.", "The physical resources may include at least a network adaptor.", "Virtualized resources may be loaded in the memory circuitry, the virtualized resources including at least VMs and interfaces corresponding to each of the VMs, the interfaces including a physical interface, a virtual interface and a super virtual interface.", "The processing circuitry may be to at least cause a VM and a corresponding physical interface, virtual interface or super virtual interface to be loaded into the memory circuitry as part of the virtualized resources.", "In at least one embodiment, the network adaptor may be configured to operate utilizing single root input/output virtualization (SR-IOV).", "The physical interface may be to, for example, provide to the corresponding VM a first set of capabilities to control the network adaptor.", "The capabilities may include the ability to access at least one register in the device for controlling operation of at least the network adaptor.", "The virtual interface may be to, for example, provide to the corresponding VM a second set of capabilities that is a subset of the capabilities included in the first set.", "The super virtual interface may be to, for example, provide to the corresponding VM a third set of capabilities including the second set of capabilities and at least one additional capability included in the first set.", "In at least one embodiment, the processing circuitry may be to cause a virtual machine manager (VMM) to be loaded into the memory circuitry.", "The VMM may be to determine that a VM is to be loaded into the memory circuitry.", "The VMM may further be to determine whether to load a physical interface, virtual interface or super virtual interface.", "In determining to load the super virtual interface, the VMM may be to determine at least one additional capability.", "In determining the at least one additional capability, the VMM may be to determine whether the VM is allowed to access the at least one additional capability based on a security configuration.", "Consistent with the present disclosure, a method for virtualized operation may comprise, for example, determining that a VM is to be loaded into memory circuitry in a device, determining at least one of a physical interface, a virtual interface or a super virtual interface to be loaded corresponding to the VM, the physical interface, virtual interface or super virtual interface allowing the VM to access a network adaptor in the device, and loading the VM and the determined at least one of the physical interface, virtual interface or super virtual interface into the memory circuitry.", "FIG.", "1 illustrates an example system including enhanced virtual function capabilities in a virtualized network environment in accordance with at least one embodiment of the present disclosure.", "Initially, the following may make reference to, or may use terminology commonly associated with, certain technologies for controlling the flow of data to and/or from a network such as, for example, Virtual Machine Device queues (VMDq) and SR-IOV developed by the Intel Corporation.", "These examples are offered merely for the sake of explanation, and are not intended to limit embodiments consistent with the present disclosure to any particular manner of implementation.", "While these technologies provide a basis for understanding the embodiments, actual implementations may utilize other technologies existing now or developed in the future.", "Moreover, the inclusion of an apostrophe after a drawing item number (e.g., 100′) in the present disclosure may indicate that an example embodiment of the particular item is being illustrated.", "As referenced herein, VMDq and SR-IOV are technologies that improve performance in a device by more directly routing data received from sources outside of the device via a network adaptor to a particular destination VM.", "In older architectures at least one data processor (e.g., at least one core in a microprocessor) was responsible for determining the destination for incoming data, which proved to be a bottleneck.", "In VMDq different queues having different interrupts are used to sort data for each data processor, and each data processor is then responsible for routing the data in the queue.", "However, VMDq still requires at least a VMM (e.g., hypervisor) to touch (e.g., copy) each piece of data in each queue.", "SR-IOV introduced direct memory access (DMA) to the queue-based scheme of VMDq so that incoming data may be transferred directly from a particular queue into the memory of a destination VM.", "In this manner, SR-IOV allows incoming data to be transferred to target VMs without significant interruptions to ongoing data processing.", "SR-IOV may utilize various types of interfaces (e.g., “functions” when implementing SR-IOV) to enable VMs to interact with various physical resources (e.g., a network adaptor).", "The various embodiments disclosed herein introduce a new function that may enable certain VMs to perform specialized duties by making new capabilities available.", "An example device 100 is shown in FIG.", "1.Device 100 may comprise a single apparatus or a group of apparatuses that, while having similar or different configurations, may still operate in a collaboratively manner to perform various operations associated with device 100.Examples of device 100 may include, but are not limited to, a mobile communication device such as a cellular handset or a smartphone based on the Android® OS from the Google Corporation, iOS® or Mac OS® from the Apple Corporation, Windows® OS from the Microsoft Corporation, Tizen® OS from the Linux Foundation, Firefox® OS from the Mozilla Project, Blackberry® OS from the Blackberry Corporation, Palm® OS from the Hewlett-Packard Corporation, Symbian® OS from the Symbian Foundation, etc., a mobile computing device such as a tablet computer like an iPad® from the Apple Corporation, Surface® from the Microsoft Corporation, Galaxy Tab® from the Samsung Corporation, Kindle® from the Amazon Corporation, etc., an Ultrabook® including a low-power chipset from the Intel Corporation, a netbook, a notebook, a laptop, a palmtop, etc., a wearable device such as a wristwatch form factor computing device like the Galaxy Gear® from Samsung, an eyewear form factor computing device/user interface like Google Glass® from the Google Corporation, a virtual reality (VR) headset device like the Gear VR® from the Samsung Corporation, the Oculus Rift® from the Oculus VR Corporation, etc., a typically stationary computing device such as a desktop computer, server, a group of computing devices in a high performance computing (HPC) architecture, a smart television or other “smart” device, small form factor computing solutions (e.g., for space-limited applications, TV set-top boxes, etc.)", "like the Next Unit of Computing (NUC) platform from the Intel Corporation, etc.", "As illustrated in FIG.", "1, device 100 may generally comprise at least virtualized resources 102 and physical resources 104.Virtualized resources 102 may include, for example, programs, applications, utilities, code, instructions, data, etc.", "that, upon be loaded into device 100, emulate hardware-based features of device 100.VM 106 may be an example of virtualized resources 102 in that each VM 106 may emulate the operation of an individual data processing device in device 100.Each VM 106 may, for example, be assigned a different role in device 100 such as to act as a hypervisor, firewall, router, an operational environment in which an OS executes, etc.", "Physical resources 104 may include actual equipment in device 100.Network adaptor 108 is an example of physical resources 104.Network adaptor 108 may include a network interface card (NIC) and other functionality related to routing data between device 100 and a network such as a global-area network (GAN), wide-area network (WAN) like the Internet, local area network (LAN), etc.", "An interface may be loaded corresponding to each VM 106 to allow VM 106 to interact with physical resources 104.Different types of interfaces may comprise different “capabilities” that, for example, allow VMs 106 to control the operation of network adaptor 108.Capabilities, as referenced herein, may include granting VMs 106 access to various registers for configuring network adaptor 108.In at least one embodiment, the interfaces may include physical interface 110 and one or more virtual interfaces 112.Physical interface 110 may, for example, comprise a set of capabilities 118 that grants full control over network adaptor 108 to a VM 106.Consistent with the present disclosure, only one instance of physical interface 110 may be active at a time to avoid network adaptor 108 receiving conflicting configurations from different VMs 106.Virtual interfaces 112 may include, for example, one or more standard virtual interfaces 114A .", ".", ".", "n, also identified herein simply as “virtual interfaces 114A .", ".", ".", "n”, and one or more super virtual interfaces 116A .", ".", ".", "n. Virtual interfaces 114A .", ".", ".", "n may comprise subset 120 of the full set of capabilities 118 available in physical interface 110.For example, a VM 106 may be loaded with a corresponding virtual interface 114A .", ".", ".", "n. Subset 120 in the virtual interface 114A .", ".", ".", "n may allow the VM 106 to at least configure the delivery of incoming data intended for the VM 106 (e.g., to configure the address of the memory space to which to DMA the data as in SR-IOV) in network adaptor 108.As illustrated in FIG.", "1, super virtual interfaces 116A .", ".", ".", "n may comprise at least subset 120 and at least one additional capability 122 taken from the full set of capabilities 118 available to physical interface 110.In at least one embodiment, the VMM may determine upon loading a VM 106 whether subset 120 will be sufficient or whether at least one additional capability 122 will be needed for the VM 106 to perform its intended function.", "For example, if the VM 106 to be loaded is intended to act as a firewall it may be advantageous to grant the VM 106 access to data flow control capabilities not included in subset 120.In this manner, the capabilities of super virtual interfaces 116A .", ".", ".", "n may be custom fit based on the intended operation of a corresponding VM 106.While this type of operation appears beneficial on its face, it also introduces the ability to build powerful VMs 106 that could be used to compromise the integrity of device 100 or other devices on the network, gain access to data within device 100 or other devices on the network, etc.", "In at least one embodiment, device 100 may further comprise a security configuration that checks whether a VM 106 to be loaded is entitled to utilize additional capability 122.The VMM may utilize the security configuration to determine and/or control which VMs 106 are allowed to load corresponding super virtual interfaces 116A .", ".", ".", "n (e.g., based on intended purpose, task, etc.", "), which additional capabilities 122 are available for use with super virtual interfaces 116A .", ".", ".", "n, etc.", "FIG.", "2 illustrates an example configuration for a system usable in accordance with at least one embodiment of the present disclosure.", "For example, device 100′ may be capable of performing any or all of the activities disclosed in FIG.", "1.However, device 100′ is presented only as an example of an apparatus usable in embodiments consistent with the present disclosure, and is not intended to limit any of the embodiments disclosed herein to any particular manner of implementation.", "Moreover, while depicted as only one apparatus, device 100′ may also be made up of multiple apparatuses configured to operate collaborative to perform the activities of FIG.", "1.System circuitry 200 may manage the operation of device 100′.", "System circuitry 200 may comprise, for example, processing circuitry 202, memory circuitry 204, power circuitry 206, user interface circuitry 208 and communication interface circuitry 210.Device 100′ may further include communication circuitry 212.While communication circuitry 212 is shown as separate from system circuitry 200, device 100′ is provided in FIG.", "2 merely for the sake of explanation in regard to various embodiments.", "Variations are possible including, for example, some or all of the functionality of communication circuitry 212 being incorporated into system circuitry 200.In device 100′, processing circuitry 202 may comprise one or more processors situated in separate components, or alternatively one or more processing cores in a single component (e.g., in a System-on-a-Chip (SoC) configuration), along with processor-related support circuitry (e.g., bridging interfaces, etc.).", "Example processors may include, but are not limited to, various x86-based microprocessors available from the Intel Corporation including those in the Pentium, Xeon, Itanium, Celeron, Atom, Quark, Core i-series, Core M-series product families, Advanced RISC (e.g., Reduced Instruction Set Computing) Machine or “ARM” processors, etc.", "Examples of support circuitry may include chipsets (e.g., Northbridge, Southbridge, etc.", "available from the Intel Corporation) to provide an interface through which processing circuitry 202 may interact with other system components that may be operating at different speeds, on different buses, etc.", "in device 100′.", "Moreover, some or all of the functionality commonly associated with the support circuitry may also be included in the same package as the processor (e.g., such as in the Sandy Bridge, Broadwell and Skylake families of processors available from the Intel Corporation).", "Processing circuitry 202 may be configured to execute various instructions in device 100′.", "Instructions may include program code configured to cause processing circuitry 202 to perform activities related to reading data, writing data, processing data, formulating data, converting data, transforming data, etc.", "Information (e.g., instructions, data, etc.)", "may be stored in memory circuitry 204.Memory circuitry 204 may comprise random access memory (RAM) and/or read-only memory (ROM) in a fixed or removable format.", "RAM may include volatile memory configured to hold information during the operation of device 100′ such as, for example, static RAM (SRAM) or Dynamic RAM (DRAM).", "ROM may include non-volatile (NV) memory circuitry configured based on BIOS, UEFI, etc.", "to provide instructions when device 100′ is activated, programmable memories such as electronic programmable ROMs (EPROMS), Flash, etc.", "Other examples of fixed/removable memory may include, but are not limited to, magnetic memories such as hard disk (HD) drives, electronic memories such as solid state flash memory (e.g., embedded multimedia card (eMMC), etc.", "), removable memory cards or sticks (e.g., micro storage device (uSD), USB, etc.", "), optical memories such as compact disc-based ROM (CD-ROM), Digital Video Disks (DVD), Blu-Ray Disks, etc.", "Power circuitry 206 may include, for example, internal power sources (e.g., a battery, fuel cell, etc.)", "and/or external power sources (e.g., electromechanical or solar generator, power grid, external fuel cell, etc.", "), and related circuitry configured to supply device 100′ with the power needed to operate.", "User interface circuitry 208 may include hardware and/or software to allow users to interact with device 100′ such as, for example, various input mechanisms (e.g., microphones, switches, buttons, knobs, keyboards, speakers, touch-sensitive surfaces, one or more sensors configured to capture images, video and/or sense proximity, distance, motion, gestures, orientation, biometric data, etc.)", "and various output mechanisms (e.g., speakers, displays, lighted/flashing indicators, electromechanical components for vibration, motion, etc.).", "The hardware in user interface circuitry 208 may be incorporated within device 100′ and/or may be coupled to device 100′ via a wired or wireless communication medium.", "At least some user interface circuitry 208 may be optional in certain circumstances such as, for example, a situation wherein device 100′ is a very space-limited form factor device, a server (e.g., rack server, blade server, etc.", "), etc.", "that does not include user interface circuitry 208, and instead relies on another device (e.g., a management terminal) for user interface functionality.", "Communication interface circuitry 210 may be configured to manage packet routing and other control functions for communication circuitry 212, which may include resources configured to support wired and/or wireless communications.", "In some instances, device 100′ may comprise more than one set of communication circuitry 212 (e.g., including separate physical interface circuitry for wired protocols and/or wireless radios) managed by centralized communication interface circuitry 210.Wired communications may include serial and parallel wired mediums such as, for example, Ethernet, USB, Firewire, Thunderbolt, Digital Video Interface (DVI), High-Definition Multimedia Interface (HDMI), etc.", "Wireless communications may include, for example, close-proximity wireless mediums (e.g., radio frequency (RF) such as based on the RF Identification (RFID)or Near Field Communications (NFC) standards, infrared (IR), etc.", "), short-range wireless mediums (e.g., Bluetooth, WLAN, Wi-Fi, etc.", "), long range wireless mediums (e.g., cellular wide-area radio communication technology, satellite-based communications, etc.", "), electronic communications via sound waves, etc.", "In one embodiment, communication interface circuitry 210 may be configured to prevent wireless communications that are active in communication circuitry 212 from interfering with each other.", "In performing this function, communication interface circuitry 210 may schedule activities for communication circuitry 212 based on, for example, the relative priority of messages awaiting transmission.", "While FIG.", "2 illustrates communication interface circuitry 210 and communication circuitry 212 as separate, it may also be possible for the functionality of communication interface circuitry 210 and communication circuitry 212 to be combined in the same circuitry.", "Consistent with the present disclosure, virtualized resources 102 including, for example, at least VMs 106′ physical interface 110′ and virtual interfaces 112′ may be loaded in memory circuitry 204.In particular, program code, data, etc.", "stored in a non-volatile memory in memory circuitry 204 may be loaded into volatile memory in memory circuitry 204 and then executed by processing circuitry 202 to transform processing circuitry 202 from general data processing circuitry into specialized circuitry that may be configured to at least perform operations such as discussed with respect to FIG.", "1.Moreover, network adaptor 108′ may comprise a component, components (e.g., in a chipset), an SoC, a multi-chip module, a plug-in module, a plug-in card, an external peripheral device, etc.", "in communication circuitry 212.In an example of operation, VM 106′ and corresponding interfaces 110′ or 112′ may be loaded in memory circuitry 204.VM 106′ may then interact with network adaptor 108′ via interfaces 110′ or 112′ to control certain aspects of the operation of network adaptor 108′ (e.g., to at least cause incoming data received through network adaptor 108′ to be delivered to VM 106′).", "Memory Circuitry 204 may also comprise VMM 214 to load VM 106′, physical interface 110′ and/or virtual interfaces 112′, to control the operation of VM 106′, physical interface 110′ and/or virtual interfaces 112′, etc.", "FIG.", "3 illustrates an example implementation of a system including enhanced virtual function capabilities in a virtualized network environment in accordance with at least one embodiment of the present disclosure.", "The example implementation of device 100′ in FIG.", "3 demonstrates how the functionality described in FIG.", "1 may be implemented in accordance with SR-IOV operation.", "For example, “interfaces” as generally referenced herein may be referred to “functions” in SR-IOV implementations.", "Three example VMs 106′ are shown in FIG.", "3.The first VM (VM1) 106′ loaded in virtualized resources 102′ has been loaded along with a physical function (PF) driver 300 to control the operation of SR-IOV enabled network adaptor 108′ in physical resources 104′.", "PF driver 300 300 may allow VM1 106′ to control PF 302, which in turn may control PH virtual switch interface (VSI) 304, for controlling the general operation of NIC switch 306.The second VM (VM2) 106′ is to demonstrate an example implementation for a virtual interface 114A .", ".", ".", "n. Virtual function (VF) driver 308 may be loaded corresponding to the loading of VM2 106′ to allow VM2 106′ to control VF 310, and in turn VF VSI 312, for interacting with NIC switch 306.VM2 may utilize VF driver 308 to configure VF 310 and VF VSI for delivering data (e.g., packets) from NIC switch 306 to VM2 106′ via DMA (e.g., at least the address for a memory space used by VM2 106′ may be provided as a destination for delivering incoming data).", "The third VM (VM3) 106′ is to demonstrate an example implementation for super virtual interface 116A .", ".", ".", "n. A super virtual function (SVF) driver 314 may be loaded corresponding to the loading of VM3 106′ to allow VM3 106′ to control SVF 316, and in turn SVF VSI 318 (e.g., including enhanced access), to interact with NIC switch 306.While VM3 106′ may utilize SVF driver 314 to configure SVF 316 and/or SVF VSI 318 for the delivery of data received by network adaptor 108′, at least one additional capability 122 granted to SVF 316 may allow VM3 to perform at least one other control activity at least related to the operation of network adaptor 108′.", "SR-IOV extends the PCI Express (PCIe) specification to allow network adapters 108′ to appear as multiple devices.", "In this manner, SR-IOV essentially allows network traffic to bypass VM 106′ switching software, and as a result reduces the I/O overhead associated with virtual networks.", "Both PFs 302 and VFs 310 are used by SR-IOV to manage global functions used by SR-IOV devices.", "However, per PCIe only PFs 302 have full access to configure and control a PCIe device.", "Only PF 302 is allowed to configure SR-IOV devices (e.g., network adaptor 108′), which results in long VM-EXIT latencies that are unacceptable for applications that require fast packet processing.", "Consistent with the present disclosure, some of the critical aspects of PF 302 are virtualized along with the software architecture necessary to allow VMs 106′ to obtain direct access to the PF resources.", "More powerful VF capabilities are enabled up to and including most PF capabilities utilizing SR-IOV capable network adapter 108′, which may grant to certain users such as, for example, original equipment manufacturers (OEMs) desired access, control, etc.", "A practical embodiment may include extending the boundaries of network interface card (NIC) hardware registers to allow for a number of (e.g., sixteen) SVFs 316 that may have access to more registers than a VF 310 (but not all of the capabilities of PF 302) available on an SR-IOV capable I/O device without impacting other VF registers.", "More specifically, SVF 316 may co-exist with existing VF 310 allowing, for example, telco service providers more flexibility in managing their networks.", "SVFs 316 may be controlled by network function virtualization (NFV) orchestrators allowing network operators, cloud service providers, etc.", "access to further features that are typically constrained to only those VMs 106′ having privileged PF 302 capabilities.", "A mechanism to provision SVF 316 (e.g., perhaps in an integrated NIC) may be to use a Chipset Manageability Engine (CME) via a baseboard management console (BMC).", "This approach may help provide another method to gain BMC-level access (e.g., to address a security issue directly with a particular VM 106′ using the flow director).", "Examples of capabilities that may currently be available to VF 310 in existing SR-IOV-enabled devices (e.g., network adaptor 108′) include, for example, Limited Independent interrupt vectors (e.g., as dictated by hardware), Limited VF-PF Queue-pairs (e.g., as dictated by HW wherein an upper limit is less than the PF queue pairs), Limited Receive Side Scaling (RSS) load balancing, Limited MAC VLAN filters (up to PF max allowed per VF) and Limited untrusted VF-mode (e.g., prevents promiscuous-mode).", "Consistent with the present disclosure, examples of additional capabilities 122 that may be available to SVF 316 may include, but are not limited to, a queue assignment mechanism for packets such as, for example, Ethernet Flow Director technology developed by the Intel Corporation wherein an out-of-band (OOB) pathway may be added through management resources or a Manageability Engine (ME), an ability to program NIC switch 306, an ability to block updates from a PF propagating to other VF's without a VF reset, Control Filter Configuration (e.g., Ethertype filters, Cloud filters, L3 VEB filters, Mac-VLAN filters, etc.", "), a Virtual Switch Interface (Promiscuous-mode), Mirroring for specific VSIs ingress-egress traffic, Application Target routing, Tunnel End point Offload, Add Virtual Ethernet Bridge (VEB), Enable different Switch topology with cascaded/floating VEBs, Larger RSS LUT footprint and number of PF queues to do RSS, Packet monitoring and statistics, etc.", "In at least one embodiment, network adaptor 108′ may advertise to the OS of device 100′ a capability list including all the functions that SVFs 316 can perform.", "VMM 214 may request a new virtual function and access to none, one, several additional capabilities 122.Requesting no additional capabilities 122 would be a standard VF 310, while requesting at least one additional capability 122 would result in SVF 316.A reason for allowing a VF more functionality may be based on, for example, the need for a VM to offload part or all of its software functionality.", "For example, VMM 214 may spawn a VM 106′ with a purpose of “firewalling” other VMs from the physical network.", "In that instance, VMM 214 may request access to Flow Director programming as an additional capability 122 so VM 106′ is able to allow some flows or drop in the hardware some others.", "When the firewall runs inside a VM 106′, it may use the Flow Director the same way it could as if it was running in PF 302 (e.g.", "provided that the driver is aware).", "For this the VMM needs to also be aware of the capability list that the network adaptor 108′ advertises.", "In at least one embodiment, a benefit may be realized in that the cores in processing circuitry 202 may have more bandwidth to process the applications and/or VMs 106′ instead of processing packets, improving the overall Quality of Experience (QoE) for the user.", "Also, the absence of a vSwitch running in VMM 214 conserves more cycles and reduces possible cache thrashing to other cores.", "FIG.", "4 illustrates example operations for virtualized operation in accordance with at least one embodiment of the present disclosure.", "Operations illustrated with an illustrated outline may be optional in that their inclusion may be implementation-dependent (e.g., based on the ability of the hardware/software, the intended end-use, etc.).", "A device may continue to operate as shown in operation 400 until a determination is made in operation 402 that a new VM is to be loaded.", "The determination made in operation 402 to load a new VM may be followed by determination in operation 404 of the functionality required for the new VM.", "For example, the functionality may be based on the intended task to be handled by the new VM (e.g., firewalling, data routing, acting as an operational environment for an OS, etc.).", "A determination may then be made in operation 406 as to whether a physical interface is to be loaded for the new VM.", "If in operation 408 it is determined that a physical interface is to be loaded, then in operation 408 the new VM may be loaded with a corresponding physical interface.", "Following operation 408 or a determination in operation 406 that a physical interface is not to be loaded, a further determination may then be made in operation 410 as to whether at least one virtual interface is to be loaded for the new VM.", "A determination in operation 410 that at least one virtual interface is not to be loaded may be followed by a return to operation 400 to continue with normal device operation.", "If in operation 410 it is determined that at least one virtual interface is to be loaded, then in operation 412 a further determination may be made as to whether the new VM will require enhanced functionality (e.g., at least one additional capability above that included in the set of capabilities available in a standard virtual interface).", "If in operation 412 a determination is made that no additional capabilities will be required, then in operation 414 a VM may be loaded with a corresponding standard virtual interface.", "Operation 414 may be followed by a return to operation 410 to determine whether additional virtual interfaces need to be loaded for the VM.", "If in operation 412 it is determined that at least one additional capability will be required, then optionally in operation 416 a further determination may be made as to whether the enhancement is allowed (e.g., whether the new VM is allowed to utilize the at least one additional capability).", "This determination may be made based on, for example, a security configuration in the device.", "A determination in operation 416 that the enhancement is not allowed may be followed by a return to operation 414 to load a standard virtual interface.", "If in operation 416 it is determined that the enhancement is allowed, then in operation 418 the new VM may be loaded with the corresponding super virtual interface (e.g., including the at least one additional capability).", "Operation 416 may be followed by a return to operation 410 to determine whether additional virtual interfaces need to be loaded for the VM.", "While FIG.", "4 illustrates operations according to an embodiment, it is to be understood that not all of the operations depicted in FIG.", "4 are necessary for other embodiments.", "Indeed, it is fully contemplated herein that in other embodiments of the present disclosure, the operations depicted in FIG.", "4, and/or other operations described herein, may be combined in a manner not specifically shown in any of the drawings, but still fully consistent with the present disclosure.", "Thus, claims directed to features and/or operations that are not exactly shown in one drawing are deemed within the scope and content of the present disclosure.", "As used in this application and in the claims, a list of items joined by the term “and/or” can mean any combination of the listed items.", "For example, the phrase “A, B and/or C” can mean A; B; C; A and B; A and C; B and C; or A, B and C. As used in this application and in the claims, a list of items joined by the term “at least one of” can mean any combination of the listed terms.", "For example, the phrases “at least one of A, B or C” can mean A; B; C; A and B; A and C; B and C; or A, B and C. As used in any embodiment herein, the terms “system” or “module” may refer to, for example, software, firmware and/or circuitry configured to perform any of the aforementioned operations.", "Software may be embodied as a software package, code, instructions, instruction sets and/or data recorded on non-transitory computer readable storage mediums.", "Firmware may be embodied as code, instructions or instruction sets and/or data that are hard-coded (e.g., nonvolatile) in memory devices.", "“Circuitry”, as used in any embodiment herein, may comprise, for example, singly or in any combination, hardwired circuitry, programmable circuitry such as computer processors comprising one or more individual instruction processing cores, state machine circuitry, and/or firmware that stores instructions executed by programmable circuitry.", "The circuitry may, collectively or individually, be embodied as circuitry that forms part of a larger system, for example, an integrated circuit (IC), system on-chip (SoC), desktop computers, laptop computers, tablet computers, servers, smartphones, etc.", "Any of the operations described herein may be implemented in a system that includes one or more storage mediums (e.g., non-transitory storage mediums) having stored thereon, individually or in combination, instructions that when executed by one or more processors perform the methods.", "Here, the processor may include, for example, a server CPU, a mobile device CPU, and/or other programmable circuitry.", "Also, it is intended that operations described herein may be distributed across a plurality of physical devices, such as processing structures at more than one different physical location.", "The storage medium may include any type of tangible medium, for example, any type of disk including hard disks, floppy disks, optical disks, compact disk read-only memories (CD-ROMs), compact disk rewritables (CD-RWs), and magneto-optical disks, semiconductor devices such as read-only memories (ROMs), random access memories (RAMs) such as dynamic and static RAMs, erasable programmable read-only memories (EPROMs), electrically erasable programmable read-only memories (EEPROMs), flash memories, Solid State Disks (SSDs), embedded multimedia cards (eMMCs), secure digital input/output (SDIO) cards, magnetic or optical cards, or any type of media suitable for storing electronic instructions.", "Other embodiments may be implemented as software circuitry executed by a programmable control device.", "Thus, the present disclosure is directed to enhanced virtual function capabilities in a virtualized network environment.", "In general, devices may comprise physical and virtualized resources.", "The physical resources may comprise at least a network adaptor that may handle incoming data from a network and outgoing data to the network.", "The virtualized resources may comprise at least one virtual machine (VM) and a corresponding interface.", "The corresponding interface may be one of a physical interface, a virtual interface or a “super” virtual interface.", "The physical interface may provide a first set of capabilities allowing the VM to access (e.g., control) at least the network adaptor.", "The virtual interface may provide a second set of capabilities that is a subset of the first set.", "The super virtual interface may provide a third set of capabilities including the second set of capabilities and at least one additional capability from the first set of capabilities.", "The following examples pertain to further embodiments.", "The following examples of the present disclosure may comprise subject material such as a device, a method, at least one machine-readable medium for storing instructions that when executed cause a machine to perform acts based on the method, means for performing acts based on the method and/or a system for API monitoring bypass prevention.", "According to example 1 there is provided a device capable of virtualized operation.", "The device may comprise physical resources including at least a network adaptor, memory circuitry in which virtualized resources are loaded, the virtualized resources including virtual machines and interfaces corresponding to each of the virtual machines, the interfaces including a physical interface, a virtual interface and a super virtual interface and processing circuitry to at least cause a virtual machine and a corresponding physical interface, virtual interface or super virtual interface to be loaded into the memory circuitry as part of the virtualized resources.", "Example 2 may include the elements of example 1, wherein the network adaptor is configured to operate utilizing single root input/output virtualization (SR-IOV).", "Example 3 may include the elements of example 2, wherein in SR-IOV the physical interface is a physical function (PF), the virtual interface is a virtual function (VF) and the super virtual interface is a super virtual function (SVF).", "Example 4 may include the elements of example 3, wherein the virtual machine comprises at least one of a PF driver, a VF driver or a SVF driver to interact with at least one of the PF, the VF or the SVF.", "Example 5 may include the elements of any of examples 3 to 4, wherein the PF, the VF and the SVF are loaded into the network adaptor.", "Example 6 may include the elements of example 5, wherein the network adaptor comprises a PF virtual switch interface (VSI) to provide an interface between the physical function and a network interface card (NIC) switch in the network adaptor, a VF VSI to provide an interface between the VF and the NIC switch, and a SVF VSI to provide an interface between the SVF and the NIC switch.", "Example 7 may include the elements of any of examples 1 to 6, wherein the physical interface is to provide to the corresponding virtual machine a first set of capabilities to control the network adaptor.", "Example 8 may include the elements of example 7, wherein the capabilities include the ability to access at least one register in the device for controlling operation of at least the network adaptor.", "Example 9 may include the elements of any of examples 7 to 8, wherein the virtual interface is to provide to the corresponding virtual machine a second set of capabilities that is a subset of the capabilities included in the first set.", "Example 10 may include the elements of example 9, wherein the super virtual interface is to provide to the corresponding virtual machine a third set of capabilities including the second set of capabilities and at least one additional capability included in the first set.", "Example 11 may include the elements of any of examples 1 to 10, wherein the processing circuitry is to cause a virtual machine manager to be loaded into the memory circuitry.", "Example 12 may include the elements of example 11, wherein the virtual machine manager is to determine that a virtual machine is to be loaded into the memory circuitry.", "Example 13 may include the elements of example 12, wherein the virtual machine manager is to determine whether to load a physical interface, virtual interface or super virtual interface.", "Example 14 may include the elements of example 13, wherein in determining to load the super virtual interface the virtual machine manager is to determine at least one additional capability.", "Example 15 may include the elements of example 14, wherein in determining the at least one additional capability the virtual machine manager is to determine whether the virtual machine is allowed to access the at least one additional capability based on a security configuration.", "Example 16 may include the elements of any of examples 1 to 15, wherein the processing circuitry is to cause a virtual machine manager to be loaded into the memory circuitry, wherein the virtual machine manager is to determine that a virtual machine is to be loaded into the memory circuitry and whether to load a physical interface, virtual interface or super virtual interface.", "According to example 17 there is provided a method for virtualized operation.", "The method may comprise determining that a virtual machine is to be loaded into memory circuitry in a device, determining at least one of a physical interface, a virtual interface or a super virtual interface to be loaded corresponding to the virtual machine, the physical interface, virtual interface or super virtual interface allowing the virtual machine to access a network adaptor in the device and loading the virtual machine and the determined at least one of the physical interface, virtual interface or super virtual interface into the memory circuitry.", "Example 18 may include the elements of example 17, wherein the physical interface provides to the corresponding virtual machine a first set of capabilities to control the network adaptor.", "Example 19 may include the elements of example 18, wherein the capabilities include the ability to access at least one register in the device for controlling operation of at least the network adaptor.", "Example 20 may include the elements of any of examples 18 to 19, wherein the virtual interface provides to the corresponding virtual machine a second set of capabilities that is a subset of the capabilities included in the first set.", "Example 21 may include the elements of example 20, wherein the super virtual interface provides to the corresponding virtual machine a third set of capabilities including the second set of capabilities and at least one additional capability included in the first set.", "Example 22 may include the elements of example 21, and may further comprise determining the at least one additional capability when it is determined that a super virtual interface is to be loaded.", "Example 23 may include the elements of example 22, and may further comprise determining whether the virtual machine is allowed to access at least one additional capability based on a security configuration in the device.", "Example 24 may include the elements of any of examples 17 to 23, wherein two or more interfaces are loaded for a single virtual machine.", "According to example 25 there is provided a system including at least one device, the system being arranged to perform the method of any of the above examples 17 to 24.According to example 26 there is provided a chipset arranged to perform the method of any of the above examples 17 to 24.According to example 27 there is provided at least one machine readable medium comprising a plurality of instructions that, in response to be being executed on a computing device, cause the computing device to carry out the method according to any of the above examples 17 to 24.According to example 28 there is provided at least one device capable of virtualized operation, the at least one device being arranged to perform the method of any of the above examples 17 to 24.According to example 29 there is provided a system for virtualized operation.", "The system may comprise means for determining that a virtual machine is to be loaded into memory circuitry in a device, means for determining at least one of a physical interface, a virtual interface or a super virtual interface to be loaded corresponding to the virtual machine, the physical interface, virtual interface or super virtual interface allowing the virtual machine to access a network adaptor in the device and means for loading the virtual machine and the determined at least one of the physical interface, virtual interface or super virtual interface into the memory circuitry.", "Example 30 may include the elements of example 29, wherein the physical interface is to provide to the corresponding virtual machine a first set of capabilities to control the network adaptor.", "Example 31 may include the elements of example 30, wherein the capabilities include the ability to access at least one register in the device for controlling operation of at least the network adaptor.", "Example 32 may include the elements of any of examples 30 to 31, wherein the virtual interface is to provide to the corresponding virtual machine a second set of capabilities that is a subset of the capabilities included in the first set.", "Example 33 may include the elements of example 32, wherein the super virtual interface is to provide to the corresponding virtual machine a third set of capabilities including the second set of capabilities and at least one additional capability included in the first set.", "Example 34 may include the elements of example 33, and may further comprise means for determining the at least one additional capability when it is determined that a super virtual interface is to be loaded.", "Example 35 may include the elements of example 34, and may further comprise means for determining whether the virtual machine is allowed to access at least one additional capability based on a security configuration in the device.", "Example 36 may include the elements of any of examples 29 to 35, wherein two or more interfaces are loaded for a single virtual machine.", "The terms and expressions which have been employed herein are used as terms of description and not of limitation, and there is no intention, in the use of such terms and expressions, of excluding any equivalents of the features shown and described (or portions thereof), and it is recognized that various modifications are possible within the scope of the claims.", "Accordingly, the claims are intended to cover all such equivalents." ] ]
Patent_15874266
[ [ "VICTIM RETRIEVAL SYSTEM, METHOD AND APPRATUS", "A victim retrieval apparatus for use with a vehicle.", "In some embodiments, the rescue basket comprises one or more wheels.", "The articulating head of the boom comprises a rotatable pulley for receiving the rescue line and is able to allow the vehicle to be parked in any position necessary while rescuing the victim.", "A knot-passing pulley enables a safety line (with emergency brake device) to be coupled to the basket thereby ensuring the safety of the victim in the basket at all times.", "The rescue basket comprises a remote control for controlling the winch speed that is able to be located at the winch itself, or be of a hand-held nature and attached at the rescue basket instead of at the vehicle if visual contact is problematic." ], [ "1-21.", "(canceled) 22.A boom for use with a retrieval apparatus, the boom comprising: a boom head having a body comprising one or more beam cavities, a pulley channel and a safety pulley; one or more support beams detachably coupled within the beam cavities; and a rotatable pulley rotatably coupled within the pulley channel.", "23.The boom of claim 22 wherein the support beams each comprise an angled stub configured to couple with a hitch of an anchor object.", "24.The boom of claim 23 further comprising one or more support members detachably coupled to the support beams between the stubs and the boom head.", "25.The boom of claim 22 wherein the rotatable pulley comprises a bearing element positioned between the rotatable pulley and the pulley channel for facilitating the rotation of the rotatable pulley within the pulley channel.", "26.The boom of claim 25 wherein the bearing element comprises a protective collar or one or more ball bearings.", "27.The boom of claim 22 further comprising a reel mechanism that is detachably coupled to the support beams.", "28.The boom of claim 27 wherein the reel mechanism comprises a base plate and the support beams each comprise a stop channel that receives the base plate when the reel mechanism is coupled to the support beams.", "29.The boom of claim 28 wherein the stop channels each comprise a side wall that abuts the side of the base plate when the reel mechanism is coupled to the support beams such that the reel mechanism is prevented from moving laterally with respect to the boom.", "30.The boom of claim 28 wherein the base plate comprising a plurality of plate apertures and the support beams each comprise a beam apertures that align with one of the plate apertures when the reel mechanism is coupled to the support beams.", "31.The boom of claim 30 further comprising a pin for each of the plate apertures that are positioned within the aligned plate and beam apertures in order to secure the reel mechanism to the support beams.", "32-50.", "(canceled)" ], [ "<SOH> BACKGROUND OF INVENTION <EOH>When a vehicle exits a roadway or other terrain, over-bank or cliff accidents occur.", "Victims are found down the embankment or cliff and in need of extrication and retrieval/rescue.", "These rescues are able to be particularly difficult because rescuers must be able to quickly and safely reach the victim without injury.", "The injured must be carefully retrieved in order to prevent further injury during retrieval.", "Rescue vehicles and personnel arriving on scene utilize a Z-Pulley System which is anchored to the vehicle using knots or a chock attached to the proximal end of the rope of the Z-Pulley System and is inserted into the spokes on the fire engine wheel or coupled directly to the fire engine itself.", "The Z-Pulley system can also be coupled to a tree or other stanchion.", "Rescues with the Z-pulley system setup are time consuming, require up to eight (8) responders, and provide at best a slow, bumpy ride up as rescuers negotiate the often dangerous terrain on foot while attempting to steady the basket containing the victim with sheer muscle." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Embodiments of the present invention are directed to a victim retrieval apparatus for use with a rescue vehicle.", "In some embodiments, the victim retrieval apparatus comprises a winch, a remote control for operating the winch, a fairlead assembly, rope or cable, side-load straps, large eye-bolts to secure the side-load straps, a two-piece head assembly that rotates to support loads in any direction without altering the parked position of the rescue vehicle.", "In some embodiments, the victim retrieval apparatus also comprises an adjustable strap system for leveling a rescue basket, rappelling harnesses for rescuers, a set of large carabineers and a rescue basket that is able to have a variety of vital sign detecting equipment and other rescue equipment.", "In some embodiments, the rescue basket comprises one or more wheels attached to the underside.", "The victim retrieval apparatus is able to also contain the addition of a capstan winch combined with a knot-passing pulley apparatus in case of a more distant point of rescue.", "A manned safety line and pulley (with emergency brake device) are coupled to the bottom of the rotating head assembly to ensure the position of the basket carrying the victim will not change should the main safety rope fail.", "In some embodiments, the rescue basket also comprises a remote control for controlling the winch at the rescue basket or other positions remote from the vehicle, instead of at the vehicle where vision to the basket is able to be problematic.", "In operation, two rescuers are attached to the basket's downslope edge.", "They descend with the basket using their feet on the slope to maintain position while being allowed to descend by the winch on the vehicle above.", "The victim retrieval apparatus requires only a few minutes for assembly after the rescue vehicle arrives on scene.", "It is secured by a safety line and is remotely controlled to safely ferry rescuers to a victim down an embankment thus eliminating the need for visual signals between an operator at the vehicle and the rescuers at the basket.", "Thus, victim retrieval apparatus reduces the number of responders required to three (3), reduces the time down and up the embankment by half, and, due to its unique design, requires much less physical exertion by the rescuers while providing a stable platform that minimizes bumps and jostling the victim during ascent.", "A first aspect of the present application is directed to a victim retrieval apparatus for retrieving victims from an area.", "The apparatus comprises a reel mechanism configured to controllably reel in or let out a tow line, a basket coupled to the reel mechanism via the tow line and a boom having a boom head, a rotatable pulley and one or more support beams, wherein the tow line is threaded from the reel mechanism to the basket through the boom head and onto the rotational pulley such that the rotational pulley rotates based on the outgoing angle of the tow line.", "In some embodiments, the support beams and rotatable pulley are detachably coupled together by the boom head.", "In some embodiments, the apparatus further comprises an anchor object having one or more hitches, wherein the support beams of the boom are detachably coupled to the anchor object via the hitches.", "In some embodiments, the apparatus further comprises one or more support members coupled between the support beams and the anchor object.", "In some embodiments, the anchor object is a vehicle.", "In some embodiments, the apparatus further comprises a safety line coupled to the basket, wherein safety line is positioned though a safety pulley on the boom head.", "In some embodiments, the basket comprises one or more wheels positioned on the bottom of the basket such that the basket is able to roll on the wheels.", "In some embodiments, the wheels are extendable such that the basket is able to be raised to a desired height while being supported by the wheels.", "In some embodiments, the basket comprises a controller that controls the operation of the reel mechanism.", "In some embodiments, the controller is detachably coupled to the basket.", "In some embodiments, the controller is a wireless controller that wirelessly communicates with and controls the reel mechanism.", "In some embodiments, the controller is voice activated.", "In some embodiments, the basket comprises a lifting rail positioned along the perimeter of a body of the basket.", "In some embodiments, the basket comprises a plurality of adjustable straps that are able to be adjusted in length and couple the basket to the tow line.", "In some embodiments, the apparatus further comprises a fair lead device coupled to the reel mechanism, wherein the fair lead device receives the tow line before the tow line enters or exits the reel mechanism in order to prevent the tow line from binding.", "In some embodiments, the apparatus further comprises a second reel mechanism coupled to the reel mechanism and the tow line for increasing the reeling power of the apparatus.", "In some embodiments, the apparatus further comprises a load alarm mechanism coupled with the reel mechanism such that during operation of the reel mechanism the load alarm mechanism is able to monitor the load on the reel mechanism.", "In some embodiments, the load alarm mechanism is configured to stop the reeling of the reeling mechanism if the detected load reaches a predetermined load threshold.", "In some embodiments, the load alarm mechanism is configured to cause one or more alarm signals to be output if the reel mechanism is in operation, if the detected load reaches the predetermined load threshold or if the detected load is approaching the predetermined load threshold.", "In some embodiments, the one or more alarm signals comprise one or more of audio signals, radio frequency signals and bluetooth signals.", "A second aspect of the invention is directed to a boom for use with a retrieval apparatus.", "The boom comprises a boom head having a body comprising one or more beam cavities, a pulley channel and a safety pulley, one or more support beams detachably coupled within the beam cavities and a rotatable pulley rotatably coupled within the pulley channel.", "In some embodiments, the support beams each comprise an angled stub configured to couple with a hitch of an anchor object.", "In some embodiments, the boom further comprises one or more support members detachably coupled to the support beams between the stubs and the boom head.", "In some embodiments, the rotatable pulley comprises a bearing element positioned between the rotatable pulley and the pulley channel for facilitating the rotation of the rotatable pulley within the pulley channel In some embodiments, the bearing element comprises a protective collar or one or more ball bearings.", "In some embodiments, the boom further comprises a reel mechanism that is detachably coupled to the support beams.", "In some embodiments, the reel mechanism comprises a base plate and the support beams each comprise a stop channel that receives the base plate when the reel mechanism is coupled to the support beams.", "In some embodiments, the stop channels each comprise a side wall that abuts the side of the base plate when the reel mechanism is coupled to the support beams such that the reel mechanism is prevented from moving laterally with respect to the boom.", "In some embodiments, the base plate comprising a plurality of plate apertures and the support beams each comprise a beam apertures that align with one of the plate apertures when the reel mechanism is coupled to the support beams.", "In some embodiments, the boom further comprises a pin for each of the plate apertures that are positioned within the aligned plate and beam apertures in order to secure the reel mechanism to the support beams.", "A third aspect of the invention is directed to a method of retrieving a victim from an area.", "The method comprises coupling together one or more support beams and a rotatable pulley with a boom head in order to form a boom, coupling the boom to an anchor object with the support beams, coupling a tow line from a feed mechanism to a basket by threading the tow line through the boom head onto the rotatable pulley and to the basket, wherein the rotatable pulley rotates based on the outgoing angle of the tow line and activating the feed mechanism with a controller such that the basket is retracted or extended as desired by reeling in or letting out the tow line.", "In some embodiments, the method further comprises coupling a rescue line from a secure point to the basket by threading the rescue line through a safety pulley coupled to the boom head.", "In some embodiments, the basket comprises one or more wheels positioned on the bottom of the basket.", "In some embodiments, the method further comprises extending the one or more wheels of the basket to a desired height.", "In some embodiments, the method further comprises coupling one or more support members between the support beams and the anchor object.", "In some embodiments, the anchor object is a vehicle.", "In some embodiments, the basket comprises a controller that controls the operation of the reel mechanism.", "In some embodiments, the controller is detachably coupled to the basket.", "In some embodiments, the activation of the feed mechanism comprises issuing voice commands to the controller.", "In some embodiments, the controller is a wireless controller that wirelessly communicates with and controls the reel mechanism.", "In some embodiments, the basket comprises a lifting rail positioned along the perimeter of a body of the basket, further comprising a rescuer coupling to basket via the lifting rail.", "In some embodiments, the basket comprises a plurality of adjustable straps that couple the basket to the tow line, further comprising a rescuer adjusting the length of the adjustable straps in order to level the basket.", "In some embodiments, the method further comprises a fair lead device coupled to the reel mechanism, wherein the fair lead device receives the tow line before the tow line enters or exits the reel mechanism in order to prevent the tow line from binding.", "In some embodiments, the method further comprises a second reel mechanism coupled to the reel mechanism and the tow line for increasing the reeling power of the apparatus, wherein the activation comprises controlling the second reel mechanism with the controller.", "In some embodiments, the reel mechanism is detachably coupled to the one or more support beams of the boom.", "In some embodiments, the method further comprises a load alarm mechanism coupled with the reel mechanism such that during operation of the reel mechanism the load alarm mechanism is able to monitor the load on the reel mechanism.", "In some embodiments, the load alarm mechanism is configured to stop the reeling of the reeling mechanism if the detected load reaches a predetermined load threshold.", "In some embodiments, the load alarm mechanism is configured to cause one or more alarm signals to be output if the reel mechanism is in operation, if the detected load reaches the predetermined load threshold or if the detected load is approaching the predetermined load threshold.", "In some embodiments, the one or more alarm signals comprise one or more of audio signals, radio frequency signals and bluetooth signals." ], [ "RELATED APPLICATIONS This application claims priority under 35 U.S.C.", "section 119(e) of co-pending U.S.", "Provisional Patent Application No.", "61/509,941, filed Jul.", "20, 2011, and entitled “Rescue Hoist System, Method and Apparatus,” which is hereby incorporated by reference.", "FIELD OF THE INVENTION The invention relates to rescue by a mechanically assisted rescue hoist of victims from down an embankment.", "In particular, the invention relates to a rescue apparatus for providing a quick descent for rescuers from an ingress point and safe ascent for victims, cargo and rescuers to the egress point, which is the location from which the victim or cargo is being recovered.", "BACKGROUND OF INVENTION When a vehicle exits a roadway or other terrain, over-bank or cliff accidents occur.", "Victims are found down the embankment or cliff and in need of extrication and retrieval/rescue.", "These rescues are able to be particularly difficult because rescuers must be able to quickly and safely reach the victim without injury.", "The injured must be carefully retrieved in order to prevent further injury during retrieval.", "Rescue vehicles and personnel arriving on scene utilize a Z-Pulley System which is anchored to the vehicle using knots or a chock attached to the proximal end of the rope of the Z-Pulley System and is inserted into the spokes on the fire engine wheel or coupled directly to the fire engine itself.", "The Z-Pulley system can also be coupled to a tree or other stanchion.", "Rescues with the Z-pulley system setup are time consuming, require up to eight (8) responders, and provide at best a slow, bumpy ride up as rescuers negotiate the often dangerous terrain on foot while attempting to steady the basket containing the victim with sheer muscle.", "SUMMARY OF THE INVENTION Embodiments of the present invention are directed to a victim retrieval apparatus for use with a rescue vehicle.", "In some embodiments, the victim retrieval apparatus comprises a winch, a remote control for operating the winch, a fairlead assembly, rope or cable, side-load straps, large eye-bolts to secure the side-load straps, a two-piece head assembly that rotates to support loads in any direction without altering the parked position of the rescue vehicle.", "In some embodiments, the victim retrieval apparatus also comprises an adjustable strap system for leveling a rescue basket, rappelling harnesses for rescuers, a set of large carabineers and a rescue basket that is able to have a variety of vital sign detecting equipment and other rescue equipment.", "In some embodiments, the rescue basket comprises one or more wheels attached to the underside.", "The victim retrieval apparatus is able to also contain the addition of a capstan winch combined with a knot-passing pulley apparatus in case of a more distant point of rescue.", "A manned safety line and pulley (with emergency brake device) are coupled to the bottom of the rotating head assembly to ensure the position of the basket carrying the victim will not change should the main safety rope fail.", "In some embodiments, the rescue basket also comprises a remote control for controlling the winch at the rescue basket or other positions remote from the vehicle, instead of at the vehicle where vision to the basket is able to be problematic.", "In operation, two rescuers are attached to the basket's downslope edge.", "They descend with the basket using their feet on the slope to maintain position while being allowed to descend by the winch on the vehicle above.", "The victim retrieval apparatus requires only a few minutes for assembly after the rescue vehicle arrives on scene.", "It is secured by a safety line and is remotely controlled to safely ferry rescuers to a victim down an embankment thus eliminating the need for visual signals between an operator at the vehicle and the rescuers at the basket.", "Thus, victim retrieval apparatus reduces the number of responders required to three (3), reduces the time down and up the embankment by half, and, due to its unique design, requires much less physical exertion by the rescuers while providing a stable platform that minimizes bumps and jostling the victim during ascent.", "A first aspect of the present application is directed to a victim retrieval apparatus for retrieving victims from an area.", "The apparatus comprises a reel mechanism configured to controllably reel in or let out a tow line, a basket coupled to the reel mechanism via the tow line and a boom having a boom head, a rotatable pulley and one or more support beams, wherein the tow line is threaded from the reel mechanism to the basket through the boom head and onto the rotational pulley such that the rotational pulley rotates based on the outgoing angle of the tow line.", "In some embodiments, the support beams and rotatable pulley are detachably coupled together by the boom head.", "In some embodiments, the apparatus further comprises an anchor object having one or more hitches, wherein the support beams of the boom are detachably coupled to the anchor object via the hitches.", "In some embodiments, the apparatus further comprises one or more support members coupled between the support beams and the anchor object.", "In some embodiments, the anchor object is a vehicle.", "In some embodiments, the apparatus further comprises a safety line coupled to the basket, wherein safety line is positioned though a safety pulley on the boom head.", "In some embodiments, the basket comprises one or more wheels positioned on the bottom of the basket such that the basket is able to roll on the wheels.", "In some embodiments, the wheels are extendable such that the basket is able to be raised to a desired height while being supported by the wheels.", "In some embodiments, the basket comprises a controller that controls the operation of the reel mechanism.", "In some embodiments, the controller is detachably coupled to the basket.", "In some embodiments, the controller is a wireless controller that wirelessly communicates with and controls the reel mechanism.", "In some embodiments, the controller is voice activated.", "In some embodiments, the basket comprises a lifting rail positioned along the perimeter of a body of the basket.", "In some embodiments, the basket comprises a plurality of adjustable straps that are able to be adjusted in length and couple the basket to the tow line.", "In some embodiments, the apparatus further comprises a fair lead device coupled to the reel mechanism, wherein the fair lead device receives the tow line before the tow line enters or exits the reel mechanism in order to prevent the tow line from binding.", "In some embodiments, the apparatus further comprises a second reel mechanism coupled to the reel mechanism and the tow line for increasing the reeling power of the apparatus.", "In some embodiments, the apparatus further comprises a load alarm mechanism coupled with the reel mechanism such that during operation of the reel mechanism the load alarm mechanism is able to monitor the load on the reel mechanism.", "In some embodiments, the load alarm mechanism is configured to stop the reeling of the reeling mechanism if the detected load reaches a predetermined load threshold.", "In some embodiments, the load alarm mechanism is configured to cause one or more alarm signals to be output if the reel mechanism is in operation, if the detected load reaches the predetermined load threshold or if the detected load is approaching the predetermined load threshold.", "In some embodiments, the one or more alarm signals comprise one or more of audio signals, radio frequency signals and bluetooth signals.", "A second aspect of the invention is directed to a boom for use with a retrieval apparatus.", "The boom comprises a boom head having a body comprising one or more beam cavities, a pulley channel and a safety pulley, one or more support beams detachably coupled within the beam cavities and a rotatable pulley rotatably coupled within the pulley channel.", "In some embodiments, the support beams each comprise an angled stub configured to couple with a hitch of an anchor object.", "In some embodiments, the boom further comprises one or more support members detachably coupled to the support beams between the stubs and the boom head.", "In some embodiments, the rotatable pulley comprises a bearing element positioned between the rotatable pulley and the pulley channel for facilitating the rotation of the rotatable pulley within the pulley channel In some embodiments, the bearing element comprises a protective collar or one or more ball bearings.", "In some embodiments, the boom further comprises a reel mechanism that is detachably coupled to the support beams.", "In some embodiments, the reel mechanism comprises a base plate and the support beams each comprise a stop channel that receives the base plate when the reel mechanism is coupled to the support beams.", "In some embodiments, the stop channels each comprise a side wall that abuts the side of the base plate when the reel mechanism is coupled to the support beams such that the reel mechanism is prevented from moving laterally with respect to the boom.", "In some embodiments, the base plate comprising a plurality of plate apertures and the support beams each comprise a beam apertures that align with one of the plate apertures when the reel mechanism is coupled to the support beams.", "In some embodiments, the boom further comprises a pin for each of the plate apertures that are positioned within the aligned plate and beam apertures in order to secure the reel mechanism to the support beams.", "A third aspect of the invention is directed to a method of retrieving a victim from an area.", "The method comprises coupling together one or more support beams and a rotatable pulley with a boom head in order to form a boom, coupling the boom to an anchor object with the support beams, coupling a tow line from a feed mechanism to a basket by threading the tow line through the boom head onto the rotatable pulley and to the basket, wherein the rotatable pulley rotates based on the outgoing angle of the tow line and activating the feed mechanism with a controller such that the basket is retracted or extended as desired by reeling in or letting out the tow line.", "In some embodiments, the method further comprises coupling a rescue line from a secure point to the basket by threading the rescue line through a safety pulley coupled to the boom head.", "In some embodiments, the basket comprises one or more wheels positioned on the bottom of the basket.", "In some embodiments, the method further comprises extending the one or more wheels of the basket to a desired height.", "In some embodiments, the method further comprises coupling one or more support members between the support beams and the anchor object.", "In some embodiments, the anchor object is a vehicle.", "In some embodiments, the basket comprises a controller that controls the operation of the reel mechanism.", "In some embodiments, the controller is detachably coupled to the basket.", "In some embodiments, the activation of the feed mechanism comprises issuing voice commands to the controller.", "In some embodiments, the controller is a wireless controller that wirelessly communicates with and controls the reel mechanism.", "In some embodiments, the basket comprises a lifting rail positioned along the perimeter of a body of the basket, further comprising a rescuer coupling to basket via the lifting rail.", "In some embodiments, the basket comprises a plurality of adjustable straps that couple the basket to the tow line, further comprising a rescuer adjusting the length of the adjustable straps in order to level the basket.", "In some embodiments, the method further comprises a fair lead device coupled to the reel mechanism, wherein the fair lead device receives the tow line before the tow line enters or exits the reel mechanism in order to prevent the tow line from binding.", "In some embodiments, the method further comprises a second reel mechanism coupled to the reel mechanism and the tow line for increasing the reeling power of the apparatus, wherein the activation comprises controlling the second reel mechanism with the controller.", "In some embodiments, the reel mechanism is detachably coupled to the one or more support beams of the boom.", "In some embodiments, the method further comprises a load alarm mechanism coupled with the reel mechanism such that during operation of the reel mechanism the load alarm mechanism is able to monitor the load on the reel mechanism.", "In some embodiments, the load alarm mechanism is configured to stop the reeling of the reeling mechanism if the detected load reaches a predetermined load threshold.", "In some embodiments, the load alarm mechanism is configured to cause one or more alarm signals to be output if the reel mechanism is in operation, if the detected load reaches the predetermined load threshold or if the detected load is approaching the predetermined load threshold.", "In some embodiments, the one or more alarm signals comprise one or more of audio signals, radio frequency signals and bluetooth signals.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a profile view of a victim retrieval apparatus according to some embodiments.", "FIG.", "2 illustrates a detailed bottom view of an articulating boom according to some embodiments.", "FIG.", "3A illustrates a front view of a boom head base according to some embodiments.", "FIG.", "3B illustrates a back view of a boom head base according to some embodiments.", "FIG.", "3C illustrates a top view of a boom head base according to some embodiments.", "FIG.", "3D illustrates a bottom view of a boom head base according to some embodiments.", "FIG.", "4 illustrates a detailed view of a boom head main pulley according to some embodiments.", "FIG.", "5A illustrates a detailed view of a rescue basket according to some embodiments.", "FIG.", "5B illustrates a detailed view of a rescue basket according to some embodiments.", "FIG.", "6 illustrates a flow chart of a method of rescue a victim according to some embodiments.", "FIG.", "7A illustrates a top view of an articulating boom according to some embodiments.", "FIG.", "7B illustrates a cross-sectional view of an articulating boom according to some embodiments.", "Embodiments of the victim retrieval apparatus are described relative to the several views of the drawings.", "Where appropriate and only where identical elements are disclosed and shown in more than one drawing, the same reference numeral will be used to represent such identical elements.", "DETAILED DESCRIPTION OF THE PRESENT INVENTION Embodiments of the present invention are directed to a victim retrieval apparatus for use with any type of rescue vehicle including both smaller ones as well as much larger standard rescue apparatus like fire engines or heavy rescue vehicles.", "In some embodiments, the retrieval apparatus comprises a winch, a rescue basket with or without wheels, and a remote control that controls the speed of the winch.", "The remote control is able to be attached via an electric cord to the winch.", "Alternatively, the remote control is able to be wireless and operate using Blue-Tooth, Infra-Red technology or other technology that encompasses hand-held wireless technology.", "Thus, the remote is able to be carried separately by a rescuer as they descend with the basket or be manned at the winch by another rescuer that is reading hand signals from those below.", "The articulating head of the boom comprises a rotatable pulley for receiving the rescue line and a safety pulley mounted to the underside of the articulating head piece that enables a safety line to be coupled to the boom thereby ensuring the safety of the position of the rescue basket.", "The victim retrieval apparatus is quickly, in comparison to the current Z-pulley technique, assembled onto a vehicle and secured by a safety line and is remotely controlled both down and up the slope.", "Use of the remote control by the descending rescuers eliminates the need for hand signals between the rescuers and the person at the vehicle.", "Reference will now be made in detail to implementations of the victim retrieval system as illustrated in the accompanying drawings.", "The same reference indicators will be used throughout the drawings and the following detailed description to refer to the same or like parts.", "In the interest of clarity, not all of the routine features of the implementations described herein are shown.", "To understand the final configuration, one must know that the rescue boom apparatus is in the stored position when not in use and is assembled by being removed from the storage fixture on the rescue vehicle and installed in just a few minutes at the site of the rescue.", "It will also be appreciated that in the development of any such actual installation, numerous end-user specific features will be allowed to achieve the developer's specific goals, such as compliance with various market applications or business related constraints, and that these specific criteria will vary from one application to another and from one developer to another.", "Moreover, it will be appreciated that such a development effort might be complex and time-consuming, but would nevertheless be a routine undertaking of engineering and fabricating for those of ordinary skill in the art having the benefit of this disclosure.", "FIG.", "1 illustrates a profile view of a victim retrieval apparatus 100 according to some embodiments.", "The retrieval apparatus 100 comprises two main beams 102, one or more receiver hitches 104, a winch 106, a rescue basket 108, a rescue rope 110, a fair lead fixture 112, a safety line 116, an alarm mechanism 118 and one or more side-load straps 114.In some embodiments, the retrieval apparatus 100 comprises one or more additional components and/or one or more of the components are able to be omitted.", "For example, in some embodiments the apparatus 100 comprises one or more additional winches, for example a capstan winch, which is able to be either attached permanently to a rescue vehicle 99, or be adjacent to the winch 106 in order to provide increased distance for rescue by allowing a longer rope to be tied to the original winch rope while maintaining the mechanical assistance of the capstan winch.", "Further, in some embodiments the apparatus 100 is able to comprise one or more storage components for the retrieval apparatus 100 or accessory components (not shown), wherein the storage components are coupled to the vehicle 99 or other object for securely storing the apparatus 100 on the vehicle 99.For example, the storage components are able to comprise one or more of carry boxes, hangers with straps, welded brackets and/or industrial grade Velcro® straps coupled to the vehicle 99.Moreover, in some embodiments the apparatus 100 is able to comprise a rope gun or line launching device that is detachably coupled to the boom 102.For example, the rope gun is able to be attached to one or more of the main beams 202 of the boom 102 and used to propel a line across a distance (e.g.", "a stream) so that the line may be tied off across the distance between the apparatus 100 and a stanchion point.", "This provides the advantage of providing safer water and other difficultly traversed obstacle rescues.", "As shown in FIG.", "1, the two main beams 202 (see FIG.", "2) of the boom 102 couple to the vehicle 99 or other object via the one or more receiver hitches 104.In some embodiments, the receiver hitches 104 are able to be supplemented with or replaced by welded solid stock, hinge mechanisms, and/or other attachment mechanisms capable of securely attaching the support beams 202 to the vehicle 99 as are well known in the art.", "In some embodiments, once coupled to the receiver hitches 104, the boom 102 forms a 45 to 55 degree angle with the ground.", "Alternatively, the boom 102 is able to form other angles with the ground.", "The side load straps 114 are coupled between the vehicle 99 and the support main beams 202 of the boom 102 in order to relieve a portion of any side or transverse loads experienced by the boom 102.In some embodiments, the side-load straps 114 are able to be replaced or supplemented other suitable materials such as tube stock and/or solid tow bars that are able to snap-on or attach in other ways to the support beams 202.The winch 106 and fair lead fixture 112 are able to be coupled to the vehicle 99, wherein the rescue line 110 is fed from the winch 106 through the fair lead fixture 112 and the pulley 208 (see FIG.", "2) of the boom 102 to the point at which the line 110 couples to the rescue basket 108.The winch 106 is able to be used to control the victim retrieval by lowering the rescue basket 108, and the fair lead fixture 112 is able to prevent the rescue line 110 from binding or catching during operation of the victim retrieval apparatus 100.Further, because the pulley 208 is rotatable, the victim retrieval apparatus 100 is able to operate effectively at angles up to 0 and 180 degrees and greater with respect to the perimeter of the vehicle 99 and or the orientation of the boom 102.In some embodiments, the rescue line 110 comprises a climbing rope.", "Alternatively, the rescue line 110 is able to comprise one or more of a rope, a cable, and a winch cable or other suitable material.", "In some embodiments, the winch 106 is an electric hydraulic winch.", "Alternatively, the winch 106 is able to comprise any combination of an electric hydraulic winch, a gas hydraulic winch, a fully or partially solar powered winch, battery powered winch, a remote generator powered winch or other types of reeling mechanisms.", "In some embodiments, the fair lead fixture 112 comprises steel.", "Alternatively, the fair lead fixture 112 is able to comprise e-glass tubing with a free spinning, bushing-style design and/or a Hardigg style case.", "The alarm mechanism 118 is coupled with the winch 106 such that it is able to monitor the operation and/or load on the winch 106.As shown in FIG.", "1, the alarm mechanism 118 is integrated with the winch 106.Alternatively, the alarm mechanism 118 is able to be a separate device that is wired or wirelessly coupled with the winch 106.For example, in some embodiments the alarm mechanism 118 is able to be positioned on the rescue basket 108 while it monitors the operation and/or load on the winch 106.In operation, the alarm mechanism 118 is able to produce control signals that are used to generate and/or adjust audible or non-audible signals based on the operation of winch 106 in order to indicate the status of the winch 106.The adjustments to or different audible and/or non-audible signals are able to be produced based on whether the winch 106 is in operation, the current load on the winch 106, the change in load on the winch 106, whether the winch 106 is retracting or extending the line 110 or other statuses of the winch 106.For example, the alarm mechanism 118 is able to cause a first audible signal to be generated whenever it detects the winch 106 is in operation and a second or adjusted audible signal to be generated if it detects the load on the winch has reached a predetermined threshold (e.g.", "the load limit of the winch 106).", "Similarly, the alarm mechanism 118 is able to cause first and second/adjusted non-audible signals (e.g.", "radio frequency (RF) or bluetooth) to be generated that are received by devices of the rescuers and cause the devices to indicate that status of the winch 106 (e.g.", "in operation or at load threshold).", "Further, in some embodiments the alarm mechanism 118 is able to produce control signals that automatically stop the operation such as the reeling in or retracting of the line 110 by the winch 106 when the alarm mechanism 118 detects that the predetermined load threshold has been reached.", "For example, if the operator is retracting the line 110 to retrieve a victim and the load on the line 110 reaches the load threshold, the alarm mechanism 118 will lock the line in place, thereby not releasing the line, but preventing the load from exceeding the threshold.", "As a result, the alarm mechanism 118 is able to provide the benefit of preventing the operator from exceeding a predefined load limit (e.g.", "the load limit of the winch) and thereby risking malfunction and/or failure of the winch 106 and/or line 110.As a result, the alarm mechanism 118 is able to provide a warning to the operators that operation has begun and/or that the winch 106 is reaching or has reached its load limit.", "The alarm mechanism 118 is able to adjust the frequency, pitch and/or volume of the audible signals based on the operation and/or load on the winch 106.For example, the mechanism 118 is able to increase, decrease or otherwise adjust the frequency, volume and/or pitch of the signals as the winch 106 begins operations and/or as the load on the winch 106 increases, decreases and/or approaches a predetermined load threshold.", "In some embodiments, the alarm mechanism 118 comprises one or more speakers that output audible alarm signals.", "Alternatively, the alarm mechanism 118 is able to couple with and control remote audio mechanisms for producing audible alarm signals.", "For example, the alarm mechanism 118 is able to wired or wirelessly couple to the vehicle 99 in order to utilize the horn or other audio generating mechanisms of the vehicle in order to produce the audible alarm signals.", "In some embodiments, the alarm mechanism 118 is able to transmit and/or receive bluetooth, RF and/or other types of signals.", "For example, the alarm mechanism 118 is able to utilize bluetooth, RF or other types of signals as the control signals to couple with and control the vehicle 99 and/or to send an alarm signal to a device carried by the rescuers that indicates the alarm to the rescuers.", "In some embodiments, the alarm mechanism 118 is programmable such that under what conditions the signals are produced (e.g.", "when in operation, at a predetermined load threshold) and the type signals produced for each condition is able to be selectively programmed by a user.", "As a result, the alarm mechanism 118 provides the advantage of adjusting for different types of winches and systems having different load tolerances and other characteristics.", "FIG.", "2 illustrates a detailed bottom view of the articulating rescue boom 102 according to some embodiments.", "As shown in FIG.", "2, the assembled articulating rescue boom 102 comprises a plurality of support beams 202 coupled to receiver hitch stubs 204, a boom head base 206 and a boom head main pulley 208.The support beams 202 utilize the stubs 204 to couple to the receiver hitches 104 as shown in FIG.", "1.The receiver hitches 104 are able to be secured to the vehicle 99 with one or more angle transition plates 210.The boom head base 206 couples the top of the support beams 202 together and provides a pulley channel 306 (see FIGS.", "3A-D) for receiving the boom head main pulley 208.In some embodiments, the support beams 202 comprise steel tubing.", "Alternatively, the support beams 202 are able to comprise any combination of steel, titanium and/or composite materials (e.g.", "S-glass or E-glass), carbon fiber (e.g.", "using custom wrap angles), and other resins/epoxies as are well known in the art.", "In some embodiments, the support beams 202 are coated with a composite layer and/or other polymer products for providing increased corrosion resistance.", "FIGS.", "3A-3D illustrate a front, back, top and bottom view of the rescue boom head base 206 according to some embodiments.", "Specifically, the boom head base 206 comprises a pair of locking pins 308, a knot-passing pulley 310 and a body 302 having a pair of support beam cavities 304 and a main pulley channel 306.The support beam cavities 304 are positioned at angles to receive the support beams 202 wherein the locking pins 308 are able to lock the support beams 202 within the support beam cavities 304 thereby securing the top of the boom 102 together.", "Alternatively, the support beams 202 are able to be secured within the support beam cavities 304 using other types of fasteners as are well known in the art.", "The channel 306 is configured to receive the body of the main pulley 208 and enable the main pulley 208 to rotate within the channel 306 as needed during operation of the apparatus 100.The knot-passing pulley 310 for receiving the safety line 116 is coupled to the bottom of the boom head base 206 such that the knot-passing pulley 310 is able to be coupled to a safety line 116 (see FIG.", "1) when the boom 102 is in operation in order to further ensure a static location of the rescue basket should a failure occur in the main rescue apparatus system allowing the main rescue line to contain unwanted and instant slack.", "The attached side load straps 114, attached to the main beams 202 provide the advantage that in the case of failure of a portion of the apparatus 100, these side load straps 114 will also ensure the rescuers and victims are not injured by the failure.", "FIG.", "4 illustrates a detailed view of the boom head main pulley 208 according to some embodiments.", "As shown in FIG.", "4, the main pulley 208 comprises a cylindrical hollow body 402 serving as the rescue line channel 408, a pulley head 404 and a collar bearing 406.The body 402 of the main pulley 208 is sized so that it is able to slide into the channel 306.The rescue line channel 408 enables the rescue line 110 to be threaded through the body 402 of the main pulley 208 and around the pulley head 404, wherein the main pulley 208 is then able to be inserted into the channel 306 of the boom head base 206.As a result, the main pulley 208 is able to freely rotate within the channel 306 as rescue line 110 is moved with respect to the boom 102.The collar bearing 406 is configured to abut the bottom of the pulley head 404 and the top of the channel 306 of the base 206, such that the bearing 406 enables the main pulley 208 to rotate within the channel 306, while receiving the weight of the victim being hoisted, without damaging the body 402 of the main pulley 208 or the body of the base 206.In some embodiments, the bearing 406 comprises brass.", "Alternatively, the bearing 406 is able to comprise any combination of brass, nylon or other composite materials as are well known in the art.", "In some embodiments, the collar bearing 406 is able to be replaced with one or more ball bearings or other types of bearings as are well known in the art.", "FIGS.", "5A and 5B illustrate detailed views of the rescue basket 108 according to some embodiments.", "In some embodiments, the rescue basket 108 is able to have metal rails 508 and be certified and designated for short-haul use as described by fire departments for use to rescue victims in an over-bank type rescue so as to allow for attachments of leveling straps 504 and carabineers 512.As shown in FIG.", "5A, the rescue basket 108 comprises a body 502, a plurality of straps 504, one or more carabineer nodes 512 and a continuous lifting rail 508.In some embodiments, the rescue basket 108 is able to further comprise one or more wheels 506 and/or a remote winch controller 510 as shown in FIG.", "5B.", "In some embodiments, the body 502 comprises a Stokes rescue basket.", "Alternatively, the body 502 is able to comprise a flat backboard, a flexible sling, or any other object designed to securely carry people or other items to be rescued.", "The plurality of straps 504 are selectively coupled together and to the perimeter of the body 502 such that the straps 504 enable the rescue line 110 to detachably couple to the basket 108.In some embodiments, the straps 504 are adjustable such that a rescuer is able to adjust the length of one or more of the straps 504 to keep the basket 108 level.", "The lifting rails 508 are coupled to the perimeter of the body 502 and sized such that one or more rescuers are able to couple to the rails 508 and lift the basket 108 while keeping their hands free to treat the victim.", "The carabineer nodes 512 enable one or more rescuers or support straps 504 to securely detachably couple to the rescue basket 108.In some embodiments, the rails 508 are aluminum.", "In some embodiments wheels 506 are coupled to the bottom of the body 502.In some embodiments, the wheels 506 are able to selectively extend or telescope such that the basket 108 is supported and is able to roll at a height above the ground.", "In some embodiments, the wheels 506 are able to selectively retract such that basket 108 is able to be rested on the body 502 without the possibility of rolling on the wheels 506.As a result, the apparatus 100 provides the advantage of enabling the rescuers to more easily guide/navigate the basket 108 to and from the victim.", "As shown in FIG.", "5B, the remote winch controller 510 is able to be detachably coupled to the body 502 by magnet, Velcro or other suitable attachment method when using the hand-held version or it is alternatively attached directly to the winch 106 by an electrical cord.", "This enables the rescuers to remotely control the operation of the winch 106 as the winch 106 raises and lowers the basket 108.As a result, the apparatus 100 provides the advantage of enabling the basket 108 to be controlled at the basket location reducing the need to maintain visual or other types of contact with the vehicle 99.This is especially beneficial when there are a limited number of rescuers available as a single rescuer is able to operate the apparatus 100 while responding to the needs of the victim.", "In some embodiments, the controller 510 comprises wireless coupling to the winch 106 and/or a voice activated command interface.", "This would enable a rescuer to control the apparatus 100 “hands free” so that their hands are able to be used to assist the victim.", "Additionally, in some embodiments, the basket 108 comprises one or more of a pulsimeter/oxymeter, an oxygen/“02” bottle, a defibrillator unit, a blood-pressure cuff, an inflatable splint, a toolbox style compartment, an automatic CPR machine, a rangefinder, and a fan-folded shock blanket that is able to be made from materials that are suitable for treating victims of shock including a battery charged electric style heated shock blanket powered by solar or other energy device such as battery with an automatic shut-off of 10 minutes, heating to a maximum of 105 degrees.", "FIG.", "6 illustrates a flow chart illustrating a method of retrieving a victim according to some embodiments.", "A rescuer assembles and couples the boom 102 onto the vehicle 99 at the step 602.The rescuer threads the rescue line 110 from the winch 106 through the main pulley 404 of the boom 102 at the step 604.The rescuer attaches the rescue line 110 to the rescue basket or other container 108 at the step 606.The rescuer passes a rescue line through a knot-passing pulley 310 of the boom head base 206 at the step 608, securing the line to the rescue basket 108.The rescuer activates the winch 106 to allow the basket 108 to be leveraged to a level position by using the rescuers as the angle of interface between the basket and the ground and by adjusting the straps 504 on the basket 504 at step 610.In some embodiments, the rescuer lowers and/or raises the basket 108 using voice commands received by the controller 510.The rescuer guides the rescue carrier 108 to the victim and back to the vehicle 99 using appropriate winch speed controlled by the remote control 510, leverage and technique of the rescuers in combination with adjustable leveling straps 504 at the step 612.In some embodiments, the method further comprises extending the wheels 506 of the carrier/basket 108 at the top of the embankment so that the victim is able to be pushed on those wheels 506 to a waiting ambulance or other vehicle at a standard stretcher height.", "Alternatively, the wheels 506 are able to be retracted by the rescuer.", "As a result, the victim is able to be moved easily from the rescue carrier 108 to an ambulance Stryker gurney typical to most ambulances greatly reducing the amount of lifting the rescuers must do and reducing further trauma to the victim.", "FIGS.", "7A and 7B illustrate top and cross-sectional views respectively of the retrieval apparatus 700 according to some embodiments.", "The retrieval apparatus 700 shown in FIGS.", "7A and 7B is substantially similar to the retrieval apparatus 100 described above except for the differences described herein.", "In particular, as shown in FIGS.", "7A and 7B, the winch 106 of the retrieval apparatus 700 is detachably coupled to the support beams 202 instead of to the vehicle 99.As a result, the apparatus 700 provides the benefit of being able to operate with vehicles or other objects that do not have the room or capability to securely support the winch 106.As shown in FIG.", "7A, the winch 106 is permanently or detachable coupled to a base plate 702 having a plurality of plate apertures 704 and the support beams 202 each comprise a beam aperture 708 (see FIG.", "7B) that is able to align with a plate aperture 704 and a stop channel 706 having a side wall 707 protruding from a top surface of the beams 202.In some embodiments, the side wall 707 is able to be omitted.", "In some embodiments, one or more additional plate apertures 704 and corresponding beam apertures 708 are able to be added to the base plate 702 and beams 202 respectively.", "Although the plurality of plate apertures 704 are shown at the top corners of the plate 702, they are able to be positioned anywhere on the plate 702 wherein the apertures 704 are able to simultaneously align with the beam apertures 708.When coupled to the support beams 202, as shown in FIG.", "7B, the corners and/or sides of the base plate 702 are slid into the stop channels 706 such that the side walls 707 prevent the base plate 702 from moving laterally out of the stop channels 706 and the bottom and top of the stop channel 704 prevent the base plate 702 from sliding down the beams 202 or being pulled out of the stop channels 704.When positioned within the stop channels 704, the plate apertures 704 each align with one of the beam apertures 708 such that the top of the base plate 702 is able to be detachably secured to the beams 202 using a first pin 710 that slides through both the plate and beam apertures 704, 708 and a second pin 712 that secures the first pin 710 in place.", "Alternatively, other fastening means are able to be used to detachably couple the winch 106 to the beams 202.In some embodiments, the edges of the base plate 702 are angled such that they match the angle of the support beams 202 when the boom 102 is assembled.", "Alternatively, the base plate 702 is able to be comprise other shapes capable of detachably coupling to the support beams 202.As a result, the apparatus provides the advantage of an easily assembled and disassembled boom 102 having a detachably coupled winch 106 such that another mount for the winch is unnecessary.", "Thus, it is clear that the retrieval apparatus described herein has numerous advantages.", "Specifically, the victim retrieval apparatus is able to quickly be assembled onto a variety of vehicles for various types of over-bank or in any location where a victim retrieval is needed.", "Further, the apparatus provides the benefit of being able to be remotely control the operation of the victim retrieval from the carrier location instead of the vehicle location.", "This enables rescuers to react to issues that arise at the carrier location without needed to be in visual contact with a vehicle operator.", "Moreover, the victim retrieval is assembled in a fraction of the time it takes to assemble the conventional and traditional Z-Pulley method allowing for a much faster, safer and more efficient rescue for the victim.", "This ensures a safer method of rescue for the rescuers and reduces fire/rescue-related losses including human losses.", "Further, the rescue basket described herein has a variety of victim monitoring equipment and other things which are able to include a plurality of wheels reducing the friction between the basket and the terrain.", "Additionally, the victim retrieval device is able to quickly be assembled onto a vehicle, utilize remote control and assure a faster, safer and more efficient over-bank or rugged terrain rescue for both victims and rescuers alike.", "The present invention has been described in terms of specific embodiments incorporating details to facilitate the understanding of the principles of construction and operation of the invention.", "Such reference herein to specific embodiments and details thereof is not intended to limit the scope of the claims appended hereto.", "It will be apparent to those skilled in the art that modifications are able to be made in the embodiment chosen for illustration without departing from the spirit and scope of the invention.", "In particular, it is understood that although the retrieval apparatus is described herein with reference to retrieving victims, the retrieval of other objects is contemplated." ] ]
Patent_15874268
[ [ "DEPLOYMENT AND RETRIEVAL OF SEISMIC AUTONOMOUS UNDERWATER VEHICLES", "Apparatuses, systems, and methods for the deployment of a plurality of autonomous underwater seismic vehicles (AUVs) on or near the seabed based on acoustic communications with an underwater vehicle, such as a remotely operated vehicle.", "In an embodiment, the underwater vehicle is lowered from a surface vessel along with a subsea station with a plurality of AUVs.", "The AUVs are configured to acoustically communicate with the underwater vehicle or a second surface vessel for deployment and retrieval operations.", "The underwater vehicle and/or second surface vessel is configured to instruct the AUVs to leave the subsea station or underwater vehicle and to travel to their intended seabed destination.", "The underwater vehicle and/or second surface vessel is also configured to selectively instruct the AUVs to leave the seabed and return to a seabed location and/or a subsea station for retrieval." ], [ "1.A method for the deployment of a plurality of seismic nodes on or near the seabed, comprising loading a first plurality of autonomous underwater vehicles (AUVs) in an underwater vehicle on a first surface vessel, wherein each AUV comprises one or more seismic sensors and a propulsion system; lowering the underwater vehicle from the first surface vessel into a body of water; towing the underwater vehicle by the first surface vessel; launching the first plurality of AUVs from the underwater vehicle based on communications from the underwater vehicle; and deploying each of the first plurality of AUVs at a position on the seabed.", "2.The method of claim 1, further comprising guiding the first plurality of AUVs to one or more seabed locations based on communications provided by the underwater device.", "3.The method of claim 1, further comprising guiding the first plurality of AUVs to one or more seabed locations based on communications provided by a second surface vessel.", "4.The method of claim 1, further comprising guiding the first plurality of AUVs to one or more seabed locations without communications provided by the first surface vessel to the first plurality of AUVs.", "5.The method of claim 1, further comprising guiding the first plurality of AUVs from the underwater device based on communications provided by a first guidance system, and guiding the first plurality of AUVs to one or more seabed locations based on communications provided by a second guidance system.", "6.The method of claim 1, wherein the launching step is performed sequentially for each of the first plurality of AUVs as the underwater device is towed by the first surface vessel.", "7.The method of claim 1, further comprising actuating a propulsion system on the underwater device to move the underwater device during deployment of the first plurality of AUVs.", "8.The method of claim 1, further comprising deploying the first plurality of AUVs while the underwater device is in motion.", "9.The method of claim 1, wherein the loading step further comprises loading the first plurality of AUVs onto a plurality of storage devices, wherein each of the plurality of storage devices is configured to carry two or more of the first plurality of AUVs, and transferring the plurality of storage devices into a storage chamber on the underwater device.", "10.The method of claim 1, further comprising raising the underwater device to the first surface vessel; loading a second plurality of AUVs in the underwater device; lowering the underwater device into the body of water; towing the underwater vehicle by the first surface vessel; launching the second plurality of AUVs from the underwater device; and deploying each of the second plurality of AUVs at a predetermined position on the seabed.", "11.A method for the retrieval of a plurality of seismic nodes from on or near the seabed, comprising towing an underwater device in a body of water from a surface vessel; recovering a plurality of autonomous underwater vehicles (AUVs) into the underwater device while the underwater device is towed by the surface vessel, wherein each AUV comprises one or more seismic sensors and a propulsion system; and lifting the underwater device from the body of water to the surface vessel with the plurality of AUVs stored within the underwater device.", "12.The method of claim 11, further comprising guiding the plurality of AUVs to the underwater device based on communications provided by the underwater device.", "13.The method of claim 11, further comprising actuating a plurality of acoustic signals on the underwater device to guide the plurality of AUVs to the underwater device during retrieval of the plurality of AUVs.", "14.The method of claim 11, wherein the recovery step is performed while the underwater device is in motion.", "15.The method of claim 11, further comprising loading the plurality of AUVs onto a plurality of storage devices within the underwater device while the underwater device is in motion.", "16.A system for the deployment or retrieval of seismic nodes on or near the seabed, comprising an underwater vehicle coupled to a first surface vessel, wherein the underwater vehicle is configured to be lowered and raised from the first surface vessel between one or more subsea positions with a plurality of autonomous underwater vehicles (AUVs), wherein each of the AUVs comprises one or more seismic sensors and a propulsion system, wherein the underwater vehicle is configured to launch the plurality of AUVs from the underwater vehicle as it is towed by the first surface vehicle, a first guidance system and a second guidance system, wherein the first guidance system is configured to guide the plurality of AUVs from the underwater device and the second guidance system is configured to guide the plurality of AUVs to one or more seabed locations.", "17.The system of claim 16, wherein the first guidance system is located on the underwater vehicle and the second guidance system is located on a second surface vessel.", "18.The system of claim 16, wherein the second guidance system is configured to instruct the plurality of AUVs to return to the underwater device for recovery.", "19.The system of claim 16, wherein the underwater device is a remotely operated vehicle (ROV) with a propulsion system.", "20.The system of claim 16, wherein the underwater device is a cage." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Apparatuses, systems, and methods for the deployment of a plurality of autonomous underwater seismic vehicles (AUVs) on or near the seabed by using a remotely operated vehicle (ROV) or other underwater vehicle.", "Each AUV may comprise one or more seismic sensors, a propulsion system, and a guidance system, and the underwater vehicle may comprise a propulsion system and a guidance system.", "In one embodiment, a system for the deployment of seismic nodes on or near the seabed comprises a plurality of AUVs, a ROV (or underwater vehicle), and one or more surface vessels configured to communicate with the ROV and/or AUVs.", "The ROV may be coupled to AUVs that are lowered with it from a surface vessel.", "The system may include a subsea station (such as a cage or basket) that is lowered from a surface vessel to carry additional AUVs to or near the seabed, or in some embodiments the subsea station is merely lowered a short distance from the water surface and AUVs are deployed from that subsea location.", "The AUVs are configured to communicate with and be guided by the ROV instead of and/or in addition to the surface vessel.", "The ROV is configured to instruct the AUVs to leave the ROV and/or subsea station and travel to their intended seabed destination.", "The ROV is also configured to selectively instruct the AUVs to leave the seabed and return to the ROV and/or subsea station for retrieval.", "In some embodiments, a second surface vessel is used to launch the AUVs from the subsea station and/or to guide the AUVs from a position proximate to the subsea station and to the seabed.", "In one embodiment, a method for the deployment of a plurality of seismic nodes on or near the seabed comprises positioning a first plurality of AUVs near the seabed and deploying the first plurality of AUVs at predetermined positions on the seabed based on communications with an ROV or underwater vehicle.", "A second plurality of AUVs may also be deployed with the underwater vehicle, whether from a subsea station (such as a cage or basket) or the vehicle itself.", "The method may also include recovering the deployed AUVs after a seismic survey has been completed.", "For retrieval, the AUVs may be physically positioned into a ROV skid or subsea station by a robotic arm on the ROV, or the AUVs may travel to another seabed location, the ROV itself, or one or more cages or subsea stations based on communications provided by the ROV or a separate surface vessel.", "In one embodiment, an apparatus for the deployment of seismic nodes on or near the seabed comprises a ROV and a skid coupled to the ROV, wherein the skid is configured to carry a plurality of AUVs, and wherein the ROV comprises a guidance system configured to communicate with each of the plurality of AUVs, wherein the guidance system comprises an acoustic system with one or more transmitters.", "The ROV may be configured to deploy the AUVs individually or simultaneously.", "In one embodiment, the disclosed deployment system comprises a plurality of AUVs, a subsea station coupled to a first surface vessel, and a second surface vessel configured to communicate with each of the plurality of AUVs.", "The subsea station is configured to be lowered and raised by a surface vessel while carrying a plurality of AUVs.", "The system may include an underwater vehicle, such as an ROV.", "The subsea station and underwater vehicle may include an acoustics system and a propulsion system.", "Each of the subsea station, underwater vehicle, and/or surface vessels may be configured to communicate with each of the AUVs to launch them from the subsea station and to guide them to a subsea position, such as a predetermined location on the seabed.", "In one embodiment, a first communications system may launch the AUVs from the subsea station and a second communications system may guide the AUVs from a position near the subsea station to the seabed.", "The system is configured to deploy the AUVs from a surface vessel to a seabed location and to recover the AUVs from the seabed location to a surface vessel.", "In one embodiment, the disclosed deployment method comprises positioning a first plurality of AUVs in a subsea station on a first surface vessel, lowering the subsea station from the first surface vessel to a first subsea location, launching the first plurality of AUVs from the subsea station, and deploying each of the first plurality of AUVs at a predetermined position on the seabed.", "The method may include using an underwater vehicle or a second surface vessel for communications to each of the plurality of AUVs, such as launching them from the subsea station and/or guiding them to the seabed.", "The method may include launching additional pluralities of AUVs from the surface vessel in one or more subsea station.", "The method may further include recovering such AUVs from the seabed by communications with an underwater vehicle or a surface vessel into a subsea recovery station, which may or may not be the same subsea station used to deploy the AUVs." ], [ "PRIORITY The present application is a continuation of U.S. application Ser.", "No.", "14/924,555, filed on Oct. 27, 2015, which claims priority to U.S. provisional patent application No.", "62/072,263, filed on Oct. 29, 2014.The entire contents of each of the above documents is incorporated herein by reference.", "BACKGROUND OF THE INVENTION Field of the Invention This invention relates to seismology and more particularly relates to the deployment and retrieval of seismic autonomous underwater vehicles by an underwater vehicle or surface vehicle.", "Description of the Related Art Marine seismic data acquisition and processing generates a profile (image) of a geophysical structure under the seafloor.", "Reflection seismology is a method of geophysical exploration to determine the properties of the Earth's subsurface, which is especially helpful in determining an accurate location of oil and gas reservoirs or any targeted features.", "Marine reflection seismology is based on using a controlled source of energy (typically acoustic energy) that sends the energy through seawater and subsurface geologic formations.", "The transmitted acoustic energy propagates downwardly through the subsurface as acoustic waves, also referred to as seismic waves or signals.", "By measuring the time it takes for the reflections or refractions to come back to seismic receivers (also known as seismic data recorders or nodes), it is possible to evaluate the depth of features causing such reflections.", "These features may be associated with subterranean hydrocarbon deposits or other geological structures of interest.", "In general, either ocean bottom cables (OBC) or ocean bottom nodes (OBN) are placed on the seabed.", "For OBC systems, a cable is placed on the seabed by a surface vessel and may include a large number of seismic sensors, typically connected every 25 or 50 meters into the cable.", "The cable provides support to the sensors, and acts as a transmission medium for power to the sensors and data received from the sensors.", "One such commercial system is offered by Sercel under the name SeaRay®.", "Regarding OBN systems, and as compared to seismic streamers and OBC systems, OBN systems have nodes that are discrete, autonomous units (no direct connection to other nodes or to the marine vessel) where data is stored and recorded during a seismic survey.", "One such OBN system is offered by the Applicant under the name Trilobit®.", "For OBN systems, seismic data recorders are placed directly on the ocean bottom by a variety of mechanisms, including by the use of one or more of Autonomous Underwater Vehicles (AUVs), Remotely Operated Vehicles (ROVs), by dropping or diving from a surface or subsurface vessel, or by attaching autonomous nodes to a cable that is deployed behind a marine vessel.", "Autonomous ocean bottom nodes are independent seismometers, and in a typical application they are self-contained units comprising a housing, frame, skeleton, or shell that includes various internal components such as geophone and hydrophone sensors, a data recording unit, a reference clock for time synchronization, and a power source.", "The power sources are typically battery-powered, and in some instances the batteries are rechargeable.", "In operation, the nodes remain on the seafloor for an extended period of time.", "Once the data recorders are retrieved, the data is downloaded and batteries may be replaced or recharged in preparation of the next deployment.", "Various designs of ocean bottom autonomous nodes are well known in the art.", "Prior autonomous nodes include spherical shaped nodes, cylindrical shaped nodes, and disk shaped nodes.", "Other prior art systems include a deployment rope/cable with integral node casings or housings for receiving autonomous seismic nodes or data recorders.", "Some of these devices and related methods are described in more detail in the following patents, incorporated herein by reference: U.S. Pat.", "Nos.", "6,024,344; 7,310,287; 7,675,821; 7,646,670; 7,883,292; 8,427,900; and 8,675,446.Emerging technologies in marine seismic surveys need a fast and cost effective system for deploying and recovering seismic receivers that are configured to operate underwater.", "Newer technologies use AUVs that have a propulsion system and are programmed to move to desired positions and record seismic data.", "After recording the seismic data, the AUVs are instructed to return to a vessel or underwater base, such as shown in U.S.", "Publication No.", "2014/0301161 and Publication No.", "WO2014/147165, incorporated herein by reference.", "Various systems and methods have been proposed for deploying, guiding, and collecting the AUVs.", "However, none of the existing methods fully address the needs of a seismic survey that uses deployable ocean bottom AUVs to collect the seismic data.", "For example, if AUVs are to be directly deployed and recovered from a surface vessel (besides having sophisticated equipment to allow such deployment and recovery), the AUV must have enough power to travel to the bottom of the seabed and after seismic data collection, resurface back to the vessel.", "This is very challenging, particularly in deep-water situations.", "Communications between each AUV and the surface vessel likewise encounter numerous difficulties.", "A need exists for an improved method and system for deploying and retrieving AUVs on the ocean bottom, and in particular one that eliminates the requirement for each AUV to directly communicate with a surface vessel and also allows for faster deployment and recovery of the AUVs from a location other than a surface vessel.", "SUMMARY OF THE INVENTION Apparatuses, systems, and methods for the deployment of a plurality of autonomous underwater seismic vehicles (AUVs) on or near the seabed by using a remotely operated vehicle (ROV) or other underwater vehicle.", "Each AUV may comprise one or more seismic sensors, a propulsion system, and a guidance system, and the underwater vehicle may comprise a propulsion system and a guidance system.", "In one embodiment, a system for the deployment of seismic nodes on or near the seabed comprises a plurality of AUVs, a ROV (or underwater vehicle), and one or more surface vessels configured to communicate with the ROV and/or AUVs.", "The ROV may be coupled to AUVs that are lowered with it from a surface vessel.", "The system may include a subsea station (such as a cage or basket) that is lowered from a surface vessel to carry additional AUVs to or near the seabed, or in some embodiments the subsea station is merely lowered a short distance from the water surface and AUVs are deployed from that subsea location.", "The AUVs are configured to communicate with and be guided by the ROV instead of and/or in addition to the surface vessel.", "The ROV is configured to instruct the AUVs to leave the ROV and/or subsea station and travel to their intended seabed destination.", "The ROV is also configured to selectively instruct the AUVs to leave the seabed and return to the ROV and/or subsea station for retrieval.", "In some embodiments, a second surface vessel is used to launch the AUVs from the subsea station and/or to guide the AUVs from a position proximate to the subsea station and to the seabed.", "In one embodiment, a method for the deployment of a plurality of seismic nodes on or near the seabed comprises positioning a first plurality of AUVs near the seabed and deploying the first plurality of AUVs at predetermined positions on the seabed based on communications with an ROV or underwater vehicle.", "A second plurality of AUVs may also be deployed with the underwater vehicle, whether from a subsea station (such as a cage or basket) or the vehicle itself.", "The method may also include recovering the deployed AUVs after a seismic survey has been completed.", "For retrieval, the AUVs may be physically positioned into a ROV skid or subsea station by a robotic arm on the ROV, or the AUVs may travel to another seabed location, the ROV itself, or one or more cages or subsea stations based on communications provided by the ROV or a separate surface vessel.", "In one embodiment, an apparatus for the deployment of seismic nodes on or near the seabed comprises a ROV and a skid coupled to the ROV, wherein the skid is configured to carry a plurality of AUVs, and wherein the ROV comprises a guidance system configured to communicate with each of the plurality of AUVs, wherein the guidance system comprises an acoustic system with one or more transmitters.", "The ROV may be configured to deploy the AUVs individually or simultaneously.", "In one embodiment, the disclosed deployment system comprises a plurality of AUVs, a subsea station coupled to a first surface vessel, and a second surface vessel configured to communicate with each of the plurality of AUVs.", "The subsea station is configured to be lowered and raised by a surface vessel while carrying a plurality of AUVs.", "The system may include an underwater vehicle, such as an ROV.", "The subsea station and underwater vehicle may include an acoustics system and a propulsion system.", "Each of the subsea station, underwater vehicle, and/or surface vessels may be configured to communicate with each of the AUVs to launch them from the subsea station and to guide them to a subsea position, such as a predetermined location on the seabed.", "In one embodiment, a first communications system may launch the AUVs from the subsea station and a second communications system may guide the AUVs from a position near the subsea station to the seabed.", "The system is configured to deploy the AUVs from a surface vessel to a seabed location and to recover the AUVs from the seabed location to a surface vessel.", "In one embodiment, the disclosed deployment method comprises positioning a first plurality of AUVs in a subsea station on a first surface vessel, lowering the subsea station from the first surface vessel to a first subsea location, launching the first plurality of AUVs from the subsea station, and deploying each of the first plurality of AUVs at a predetermined position on the seabed.", "The method may include using an underwater vehicle or a second surface vessel for communications to each of the plurality of AUVs, such as launching them from the subsea station and/or guiding them to the seabed.", "The method may include launching additional pluralities of AUVs from the surface vessel in one or more subsea station.", "The method may further include recovering such AUVs from the seabed by communications with an underwater vehicle or a surface vessel into a subsea recovery station, which may or may not be the same subsea station used to deploy the AUVs.", "BRIEF DESCRIPTION OF THE DRAWINGS The following drawings form part of the present specification and are included to further demonstrate certain aspects of the present invention.", "The invention may be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.", "FIG.", "1 illustrates one embodiment of a schematic diagram of an AUV.", "FIG.", "2 illustrates another embodiment of a schematic diagram of an AUV.", "FIG.", "3 illustrates one embodiment of a schematic diagram of a ROV.", "FIG.", "4 illustrates one embodiment of a schematic diagram for a ROV guidance system.", "FIG.", "5 illustrates one embodiment of a ROV assisted deployment system for AUVs.", "FIG.", "6 illustrates one embodiment of a ROV assisted deployment system for AUVs.", "FIG.", "7 illustrates one embodiment of a ROV assisted retrieval system for AUVs.", "FIG.", "8 illustrates one embodiment of a ROV assisted deployment system for AUVs.", "FIG.", "9 illustrates one embodiment of an underwater vehicle assisted deployment system for AUVs.", "FIG.", "10 illustrates one embodiment of a subsea station assisted deployment system for AUVs.", "FIG.", "11 illustrates one embodiment of a method to deploy AUVs using a ROV.", "FIG.", "12 illustrates one embodiment of a method to recover AUVs using a ROV.", "FIG.", "13 illustrates one embodiment of a method to deploy and recover AUVs using a subsea station.", "DETAILED DESCRIPTION Various features and advantageous details are explained more fully with reference to the nonlimiting embodiments that are illustrated in the accompanying drawings and detailed in the following description.", "Descriptions of well known starting materials, processing techniques, components, and equipment are omitted so as not to unnecessarily obscure the invention in detail.", "It should be understood, however, that the detailed description and the specific examples, while indicating embodiments of the invention, are given by way of illustration only, and not by way of limitation.", "Various substitutions, modifications, additions, and/or rearrangements within the spirit and/or scope of the underlying inventive concept will become apparent to those skilled in the art from this disclosure.", "The following detailed description does not limit the invention.", "Reference throughout the specification to “one embodiment” or “an embodiment” means that a particular feature, structure, or characteristic described in connection with an embodiment is included in at least one embodiment of the subject matter disclosed.", "Thus, the appearance of the phrases “in one embodiment” or “in an embodiment” in various places throughout the specification is not necessarily referring to the same embodiment.", "Further, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.", "Autonomous Underwater Vehicles In one or more embodiments, an autonomous underwater vehicle (AUV) is used to record seismic signals on or near the seabed.", "An AUV in the following description is considered to encompass an autonomous self-propelled underwater seismic node that has one or more sensors capable of detecting seismic waves in a marine environment.", "The following embodiments are discussed, for simplicity, with regard to the terminology and structure of an AUV with seismic sensors for recording seismic waves.", "In general, the structure and operation of a seismic AUV is well known to those of ordinary skill.", "For example, Applicant's U.S. Pat.", "No.", "9,090,319, incorporated herein by reference, discloses one type of autonomous underwater vehicle for marine seismic surveys.", "FIG.", "1 illustrates one embodiment of AUV 100 having a body 102 in which propulsion system 103 may be located.", "Propulsion system 103 may include one or more propellers 104 and motor 106 for activating propeller 104.Other propulsion systems may be used, such as jets, thrusters, pumps, etc.", "Alternatively, the propulsion system may include adjustable wings for controlling a trajectory of the AUV.", "Motor 106 may be controlled by a processor/controller 108.Processor 108 may also be connected to seismic sensor 110.Seismic sensor 110 may have a shape such that when the AUV lands on the seabed, the seismic sensor achieves a good coupling with the seabed sediment.", "The seismic sensor may include one or more of a hydrophone, geophone, accelerometer, etc.", "For example, if a 4C (four component) survey is desired, seismic sensor 110 may include three accelerometers and a hydrophone, i.e., a total of four sensors.", "Alternatively, the seismic sensor may include three geophones and a hydrophone.", "Of course, other sensor combinations are possible, and may include one or more of a hydrophone, geophone, accelerometer, electromagnetic sensor, depth sensor, MEMs, or a combination thereof.", "Seismic sensor 110 may be located completely or partially inside body 102.Memory unit 112 may be connected to processor 108 and/or seismic sensor 110 for storing seismic data recorded by seismic sensor 110.Battery 114 may be used to power all these components.", "Battery 114 may be allowed to shift its position along a track 116 to change the AUV's center of gravity.", "This shift may be controlled by processor 108.The AUV may also include an inertial navigation system (INS) 118 configured to guide the AUV to a desired location.", "An inertial navigation system may include a module containing accelerometers, gyroscopes, magnetometers, or other motion-sensing devices.", "The INS may initially be provided with the current position and velocity of the AUV from another source, for example, a human operator, a GPS satellite receiver, a deployed ROV, another INS from the vessel, etc., and thereafter, the INS computes its own updated position and velocity by integrating (and optionally filtrating) information received from its motion sensors.", "One advantage of an INS is that it requires no external references in order to determine its position, orientation or velocity once it has been initialized.", "As noted above, alternative systems may be used, as, for example, acoustic positioning.", "An optional acoustic Doppler velocity log (DVL) (not shown) can also be employed as part of the AUV, which provides bottom-tracking capabilities for the AUV.", "Sound waves bouncing off the seabed can be used to determine the velocity vector of the AUV, and combined with a position fix, compass heading, and data from various sensors on the AUV, the position of the AUV can be determined.", "This assists in the navigation of the AUV and provides confirmation of its position relative to the seabed.", "Besides or instead of INS 118, the AUV may include compass 120 and other sensors 122 as, for example, an altimeter for measuring its altitude, a pressure gauge, an interrogator module, etc.", "The AUV 100 may optionally include an obstacle avoidance system 124 and a communication device 126 (e.g., Wi-Fi or other wireless interface, such as a device that uses an acoustic link) or other data transfer device capable of wirelessly transferring seismic data and/or control status data.", "One or more of these elements may be linked to processor 108.The AUV further includes antenna 128 (which may be flush with or protrude from the AUV's body) and corresponding acoustic system 130 for subsea communications, such as communicating with a deployed ROV (or other underwater station), another AUV, or a surface vessel or station.", "For surface communications (e.g., while the AUV is on a ship), one or more of antenna 128 and communication device 126 may be used to transfer data to and from the AUV.", "Stabilizing fins and/or wings 132 for guiding the AUV to the desired position may be used with propulsion system 103 for steering the AUV.", "However, in one embodiment, the AUV has no fins or wings.", "The AUV may include buoyancy system 134 for controlling the AUV's depth and keeping the AUV steady after landing.", "Acoustic system 130 may be an Ultra-Short Baseline (USBL) system, also sometimes known as Super Short Base Line (SSBL).", "This system uses a method of underwater acoustic positioning.", "A complete USBL system includes a transceiver or acoustic positioning system mounted on a pole under a vessel or ROV (such as Hi-PAP, commercially available by Kongsberg) and a transponder on the AUV.", "In general, a hydro-acoustic positioning system consists of both a transmitter (transducer) and a receiver (transponder).", "An acoustic positioning system uses any combination of communications principles for measurements and calculations, such as SSBL.", "In one embodiment, the acoustic positioning system transceiver comprises a spherical transducer with hundreds of individual transducer elements.", "A signal (pulse) is sent from the transducer, and is aimed towards the seabed transponder.", "This pulse activates the transponder, which responds to the vessel transducer.", "The transducer detects this return pulse and, with corresponding electronics, calculates an accurate position of the transponder relative to the vessel based on the ranges and bearing measured by the transceiver.", "In one embodiment, to calculate a subsea position, the USBL system measures the horizontal and vertical angles together with the range to the transponder (located in the AUV) to calculate a 3D position projection of the AUV relative to the ROV or the vessel.", "An error in the angle measurement causes the position error to be a function of the range to the transponder, so an USBL system has an accuracy error increasing with the range.", "Alternatively, a Short Base Line (SBL) system, an inverted short baseline (iSBL) system, or an inverted USBL (iUSBL) system may be used, the technology of which is known in the art.", "For example, in an iUSBL system, the transceiver is mounted on or inside the AUV while the transponder/responder is mounted on the surface vessel or the ROV and the AUV has knowledge of its individual position rather than relying on such position from a surface vessel (as is the case in a typical USBL system).", "In another embodiment, a long baseline (LBL) acoustic positioning system may be used.", "In a LBL system, reference beacons or transponders are mounted on the seabed around a perimeter of a work site as reference points for navigation.", "The LBL system may use an USBL system to obtain precise locations of these seabed reference points.", "Thus, in one embodiment, the reference beacon may comprise both an USBL transponder and a LBL transceiver.", "The LBL system results in very high positioning accuracy and position stability that is independent of water depth, and each AUV can have its position further determined by the LBL system.", "The acoustic positioning system may also use an acoustic protocol that utilizes wideband Direct Sequence Spread Spectrum (DSSS) signals, which provides for a greater communications range in the water.", "With regard to the AUV's internal configuration, FIG.", "2 schematically shows a possible arrangement for the internal components of an AUV 200.While FIG.", "2 illustrates an AUV with a submarine-like shape, other AUV body shapes are possible and include many cross-sectional variations, including low profile, rectangular, triangular, square, circular, flat-bottomed, etc.", "In one embodiment, AUV 200 includes CPU 202a that is connected to internal navigation system (INS) 204 (or compass or altitude sensor and acoustic transmitter for receiving acoustic guidance from the mother vessel), wireless interface 206, pressure gauge 208, and acoustic transponder 210.CPU 202a may be located in high-level control block 212.The INS is advantageous when the AUV's trajectory has been changed, for example, because of an encounter with an unexpected object (e.g., fish, debris, etc.", "), because the INS is capable of taking the AUV to the desired final position as it encounters currents, wave motion, etc.", "Also, the INS may have high precision.", "For example, an INS may be accurate up to 0.1% of the travelled distance, and a USBL system may be accurate up to 0.06% of the slant range.", "Thus, it is expected that for a target having a depth of 1000 m, the INS and/or the acoustic guidance is capable of steering the AUV within +/−1 m of the desired target location.", "The INS may be also configured to receive data from a surface vessel and/or a deployed ROV to increase its accuracy.", "An optional CPU 202b, in addition to the CPU 202a, is part of low-level control module 214 configured to control attitude actuators 216 and propulsion system 218.High-level control block 212 may communicate via a link with low-level control module 214.One or more batteries 220 may be located in AUV 200.A seismic payload 222 is located inside the AUV for recording the seismic signals.", "As another embodiment, an obstacle avoidance system may be included in the AUV, which is generally configured to detect an object in the path of the AUV and divert the AUV from its original route to avoid contact with the object.", "In one example, the obstacle avoidance system includes a forward-looking sonar.", "CPU 202a and 202b may be coupled with one or more internal components to the AUV and provide any necessary control circuitry and software for associated components.", "Those skilled in the art would appreciate that more or less modules may be added to or removed from the AUV.", "For example, if a seismic sensor is outside the AUV's body, a skirt may be provided around or next to the sensor.", "A water pump may pump water from the skirt to create a suction effect, achieving a good coupling between the sensor and the seabed.", "However, there are embodiments in which no coupling with the seabed is desired.", "For those embodiments, no skirt is used.", "Remotely Operated Vehicle In general, the structure and operation of marine ROVs are well known to those of ordinary skill.", "For example, Publication No.", "WO2014/090811, incorporated herein by reference, describes a ROV configured to deploy and retrieve autonomous seismic nodes to the seabed with a separate AUV configured to monitor and exchange data with the seismic nodes.", "Likewise, U.S. Pat.", "No.", "8,075,226, incorporated herein by reference, describes a ROV configured to physically deploy autonomous seismic nodes from a carrier located on the ROV as well as a basket lowered by a surface vessel and to mechanically connect the ROV to the lowered basket to transfer nodes from the basket to the ROV carrier.", "What is lacking in the prior art, however, is a ROV or other underwater vehicle that is configured to deploy seismic AUVs—which have the ability to travel subsea on their own—based on communications with the underwater vehicle rather than reliance only on a surface vessel communication.", "Similarly lacking in the prior art is a comprehensive communications system that is configured to deploy and recover seismic AUVs based on communications from a plurality of locations, including a second surface vessel (separate from the deployment vessel) and one or more of the cage or ROV.", "FIG.", "3 illustrates one embodiment of an underwater vehicle structure 300, which may be an ROV in one embodiment.", "ROV 300 may have frame 302 to which processor 304 and memory storage device 306 are attached.", "Plural actuators (e.g., propellers) 308 are coordinated by processor 304 for guiding the ROV underwater, and may be placed at various positions on frame 302 as is known in the art.", "ROV 300 may include robotic arm 310 for general mechanical operations underwater, including the physical movement of the AUVs during deployment and retrieval operations by handle 311.One or more cameras 312 may be attached to frame 302 for monitoring the positions of the ROV and its robotic arm while subsea.", "An operator may use cameras 312 for driving the ROV, monitoring the deployment of nodes, and for maneuvering nodes and other equipment.", "The ROV may include one or more power interfaces 330 configured to transfer power from the ROV to another device, such as AUVs 360.A data and control interface 332 may be used for transferring seismic data from AUV 360 to storage device 306, or for transferring operational instructions to the AUV.", "In one embodiment, telemetry system 318 is configured to transfer data between ROV 300 and a surface vessel through tether system 370.The ROV may be controlled by an operator from the surface through tether 370.Other electronic components 320 can be provided on the ROV for particular tasks and/or operations.", "In one embodiment, the ROV may be coupled with skid or storage chamber 350.In some embodiments, skid 350 may be integrally connected to frame 302.Skid 350 is used and configured to store and/or transfer a plurality of AUVs 360 to and from the ROV.", "Skid 350 may comprise a plurality of baskets that store the nodes.", "In one embodiment, skid 350 comprises a plurality of levels with slots, trays, or conveyors 352 on which a plurality of nodes can be stored and/or moved.", "The trays or conveyors may extend partially out from the skid and/or ROV while the AUVs are being deployed or retrieved from the ROV.", "In other embodiments, AUVs may move longitudinally along a path in the skid without a tray extending outside of the ROV.", "In one embodiment, skid 350 may have dimensions of meters, e.g., 3×3×5 meters, and is configured to be flooded with water.", "Nodes can be loaded onto skid 350 while the ROV is on the marine vessel and prior to the deployment of ROV, and may include a locking mechanism to secure AUVs while the ROV is being lowered from the vessel.", "In other embodiments, AUVs can be transferred to and from the ROV underwater via robotic arm 310, which may be attached to handle 311 for moving the nodes to and from the ROV.", "In one embodiment, skid 350 may include one or more transfer receptacles 354 to facilitate transfer of AUVs with the ROV with or without the use of robotic arm 310.For example, transfer receptacles 354 may engage and/or couple to a corresponding receptacle on a cage or basket to transfer AUVs between the ROV and cage, and in some embodiments, transfer receptacles 354 also provide power to the cage.", "Thus, during deployment, trays loaded with AUVs may be transferred to the skid and empty trays from the ROV may be returned to the cage; likewise, during retrieval, trays loaded with AUVs may be transferred from the ROV to the cage.", "Other AUV conveyance and transfer mechanisms are possible.", "In some embodiments, AUVs may be configured to launch from the ROV or be recovered to the ROV without use of the robotic arm and while the ROV is in motion and hovering above the seabed.", "An accurate position of the underwater vehicle is necessary for accurate positioning of the AUVs.", "In one embodiment, ROV 300 comprises navigation system 314 and guidance system 316.Navigation system 314 is configured to know the position of the ROV and is capable of guiding the ROV to a desired location.", "In one embodiment, navigation system 314 may comprise any one or more of the following navigation systems: INS, DVL, USBL, iSBL, iUSBL, LBL, or any combination thereof.", "In another embodiment, ROV 300 further comprises guidance system 316 for the guiding of and/or communicating to a plurality of AUVs and other subsea devices.", "One or more acoustic systems 315 may be part of and/or coupled to each of navigation system 314 and/or guidance system 316.In one embodiment, guidance system 316 may comprise any one or more of the following navigation systems: USBL, iSBL, iUSBL, or any combination thereof.", "With a known position of ROV 300, the ROV is able to provide more accurate positioning coordinates to the AUVs.", "The ROV is able to provide positioning coordinates in local or absolute grid or navigation orders to the AUVs based on pre-programmed AUV destination coordinates.", "Alternatively, AUV destination coordinates or guidance can be received from one or more surface vessels to navigation system 314 after the ROV has been deployed and when it is at or near the ocean bottom.", "Each AUV can then not only be launched from the ROV to move to its intended deployment location, but can also calculate its return path back to the ROV.", "Each AUV may be guided to a specific position based on a variety of navigation mechanisms and is configured to communicate with the ROV to receive guidance as to its position and/or destination.", "In one embodiment, the AUV knows its absolute position and can act accordingly based on its own INS and/or navigation system.", "In other embodiment, the AUV knows its relative position compared to a target or destination position and takes appropriate navigation measures to reduce the distance between its current and destination positions.", "In still another embodiment, the position of the AUV is known by the ROV and the ROV provides specific guidance to the AUV (such as heading, distance, speed, attitude, position, etc.)", "for the AUV to reach its intended destination.", "In one embodiment, the AUV is configured to receive navigation data from the ROV on the ROV's position (such as ROV speed, pitch, roll, heading) and to use such data in connection with its navigation system and to properly position the AUV in reference to the ROV.", "FIG.", "4 illustrates one embodiment of a schematic illustration of navigation system 400 that may be used by the ROV, which may comprise control system 410 that interfaces with guidance system 420 and acoustic system 470.In some embodiments, some or all of the components shown in FIG.", "4 may be used with any underwater vehicle or subsea cage or basket.", "While not shown, navigation system 400 may be coupled to any number of modules or components on the ROV, such as processor 304.In one embodiment, navigation system 400 comprises clock 412, navigation device 418, and additional electronic components 414.Navigation device 418 may include an inertial navigation system (see, e.g., INS 204), an attitude and heading reference system (AHRS), or another similar device, such as a Doppler Velocity Log (DVL).", "Navigation device 418 is used for determining an accurate position and orientation of the ROV, including position, true heading, attitude, speed and heave of the ROV.", "In one embodiment, navigation device 418 is configured to interface with one or more elements of any acoustic positioning equipment on the ROV and/or acoustic system 470.Thus, in one embodiment, navigation system 400 and/or acoustic system 470 may communicate with one or more surface vessels to obtain and/or verify the position of the ROV.", "In one embodiment, navigation system 400 includes guidance system 420 for the guiding of and/or communicating to a plurality of AUVs.", "In other embodiments, guidance system 420 is separate from and operates independently of navigation system 400 and acoustic system 470, but is configured to interface with navigation system 400 and/or acoustic system 470.In one embodiment, guidance system 420 is configured to communicate with a plurality of AUVs and to provide guidance to departing and/or arriving AUVs from the ROV while deployed in the ocean.", "In one embodiment, acoustic system 470 may be any one or more of USBL, iSBL, iUSBL, or any combination thereof and is used to communicate with and position the ROV from a surface vessel.", "In one embodiment, acoustic system 470 may comprise a plurality of acoustic transmitters 472a-b, acoustic transceiver 476, and acoustic modem 478.In some embodiments, clock 412 may be used for transmissions requiring synching, as is known in the art.", "Acoustic modem 478 is needed if there is an exchange of information or messages in an acoustic signal/message.", "Transceiver 476 communicates with an acoustic positioning system of a surface vessel and/or other sub-surface vessel or station (such as an AUV).", "In one embodiment, acoustic system 470 interfaces with guidance system 420 to position the plurality of AUVs.", "In another embodiment, acoustic system 470 is used to position both the ROV and the plurality of AUVs, and management and guidance of the ROV and AUVs is provided by a surface vessel, such as the deployment vessel or a second surface vessel.", "In this embodiment, the ROV is configured with one or more transponders, as well as an acoustic modem and a clock.", "In other embodiments, acoustic system 470 is configured to communicate with one or more surface vessels and/or one or more AUVs.", "In one embodiment, acoustic system 470 comprises transmitter 472a at proximately each of the top corners of frame 402 of the ROV and transmitter 472b attached to stand 473 in the top middle portion of the ROV.", "The stand 473 provides a different height and elevation to at least one of the plurality of transmitters.", "The transmitters 472 can be located at other positions of the ROV.", "Having more transmitters is desirable so that during a seismic survey, each AUV has a “direct view” of at least three transmitters for positioning itself.", "In one application, at least two of the transmitters are positioned within a base of a pyramid, while at least one of the transmitters is positioned at the top of the pyramid.", "In this arrangement, each AUV has the capability to position itself in a horizontal and vertical plane relative to the ocean bottom.", "In one application, a distance between two transmitters may be in the order of meters, for example, 2.5 meters, and with such a configuration, it is expected that an AUV could detect its position from 1 km away with good precision (e.g., within 1 m).", "As the technology improves, it is expected that these numbers will become even better.", "In one embodiment, each transmitter 472 emits pings and has no capability to receive signals.", "A transmitter may include a ceramic element that emits the acoustic signal and corresponding electronics unit that interacts with control system 410 and also controls the ceramic element.", "In one embodiment, the system of transmitters may form a short base line (SBL) system.", "In another embodiment, the acoustic system may form an inverted short baseline (iSBL) system.", "In one embodiment, each AUV deployed in the ocean has a different channel or code based on spread spectrum domain as to which it receives and sends communications.", "For example, an AUV may be configured to receive low frequencies in the range of 40 kHz, which provides for long distance communications.", "Thus, control system 410 and/or guidance system 420 is programmed to select appropriate frequency channels for the transmitters, to adjust the channels if necessary, and to synchronize the transmitters.", "In one embodiment, transmitters 472 are configured to send a plurality of communications over a range of frequencies, each frequency corresponding to a separate AUV, which can be selectively filtered by an AUV during reception of the transmission.", "Guidance system 420 is configured to send information from the transmitters to the AUVs.", "In one embodiment, guidance system 420 is configured to interrogate the AUVs about their position and status, selectively instruct one or more of them to return to the ROV, etc.", "Similar embodiments may be used in connection with deployment from a second surface vessel that is positioned proximate to the AUVs or a subsea cage or basket.", "In one embodiment, the configuration of the guidance system and/or acoustic system on the ROV has a corresponding match on each of the AUVs.", "For example, in one embodiment, the ROV comprises a transceiver and a plurality of transmitters while each AUV comprises at least one transponder.", "Alternatively, the ROV may comprise a plurality of transponders while each AUV comprises a transceiver.", "In either embodiment, each of the AUVs and ROV may also comprise a clock (particularly if the acoustic positioning system is synchronous) and an acoustic modem.", "System and Operation Generally, a deployment vessel stores a plurality of AUVs and a separate shooting vessel may be used to generate seismic waves.", "The shooting vessel may tow one or more seismic source arrays, each one including plural source elements.", "A source element may be an impulsive element (e.g., a gun) or a vibratory element.", "In one embodiment, the deployment vessel also tows and shoots source arrays as it deploys the AUVs.", "When the AUVs are in recording position (on the seabed), seismic waves are generated, which are recorded by the sensors on the AUVs.", "In one embodiment, the number of AUVs is in the thousands.", "In one embodiment, the deployment vessel is configured to hold all of the AUVs at the beginning of the seismic survey and then to launch them as the survey advances.", "As discussed above, with the use of an ROV or other underwater vehicle with the necessary installed systems, in one embodiment the AUVs need not have to communicate with the deployment vessel; instead, each AUV needs only to communicate with the deployed ROV.", "This system is much more accurate, fast, and cost effective than current systems to deploy seismic AUVs on the seabed.", "Further, the use of an ROV assisted guidance system for AUVs solves many problems with the prior art, as described above.", "In still other embodiments, a second surface vessel may be used that is positioned closer to the deployed AUVs than is possible with the deployment vessel.", "This second vessel may be used in addition to the ROV or in lieu of the ROV to send communications to the plurality of AUVs and to guide them to and from a seabed location.", "Still further, the lowered basket or cage itself may include various communication systems that are configured to launch the AUVs from the cage and to deploy them to the seabed (with or without communications from the ROV or second surface vessel).", "In these embodiments, one or more communications systems are used (separate from the deployment vessel) to facilitate deployment and retrieval of the AUVs.", "FIG.", "5 illustrates one system for using an ROV or other underwater vehicle to position a plurality of autonomous seismic nodes on or near seabed 3.In one embodiment, deployment vessel 510 launches ROV 550 into the ocean from surface 1.Deployment vessel 510 also launches cage or basket 520 (which may be any container or structure that is capable of holding a plurality of AUVs suitable for transfer to the seabed, which may or may not include a communications systems and a propulsion system) into the ocean, which may occur before, during, or after the deployment of ROV 550.In one embodiment, cage 520 includes a frame or housing with a base that is configured to land on the seabed.", "The cage may include a plurality of levels or slots that are configured to each hold a plurality of AUVs, such as on a conveyor, conveyor belt, carousel, or tray.", "The cage may also include a connecting mechanism for connecting to a hook or other connecting device extending from a support vessel, as well as a coupling mechanism for connecting to an ROV for the transfer of AUVs to and from the ROV.", "ROV 550 is configured with skid 530 or other similar AUV storage structure (which may be substantially similar to skid 350) that can hold a first plurality of AUVs 501a.", "In one embodiment, ROV 550 is lowered into the ocean via umbilical cable 512 and cage 520 (after being loaded with a plurality of AUVs while on board vessel 510) is lowered into the ocean by wire 522.In one embodiment, both the ROV 550 and cage 520 are lowered on or near the seabed with first plurality of AUVs 501a and second plurality of AUVs 501b, respectively.", "In some embodiments, cage 520 is lowered only a small distance beneath surface 1.In other embodiments, plurality of AUVs 501b are only lowered to the seabed in cage 520 without AUVs 501a being lowered with ROV 550.In one embodiment, ROV 550 knows the approximate initial deployment location for the AUVs and may find its desired position using, for example, an inertial navigation system (INS), which may be part of and/or coupled to guidance system 552 on ROV 550.Guidance system 552 may be substantially similar to acoustic system 315 and/or 470 of ROV (see FIGS.", "3 and 4).", "ROV is configured to know its position based on communications with surface vessel 510 (or other surface vessels).", "ROV 550 is configured to communicate with surface vessel 510 via umbilical cable 512 and/or acoustic positioning system 511 located on the vessel.", "In some embodiments, use of a neutrally buoyant tether or tether management system to ROV 550 can also be utilized, which is particularly helpful in deep-water applications.", "The use of umbilical 512 connected to the ROV provides a much faster data transfer than acoustic communications via acoustic positioning system 511, and may result in an increased update speed of the data with ROV 550.Once ROV 550 reaches a location proximal to the intended deployment location for AUVs 501a, a signal is sent from guidance system 552 to activate AUVs 501a that are stored in ROV 550.Once activated, one or more of the AUVs 501a travel to their destination (which may be on the seabed or proximal to the seabed) to get positioned for recording seismic waves.", "In one embodiment, each AUV 501a has its own channel or code based on spread spectrum domain such that ROV 550 can selectively communicate with each AUV.", "In one embodiment, each AUV 501a may be preprogrammed or partially programmed prior to launch from the ROV to find its destination position using an INS of the AUV and the coordinates of ROV 550 as a reference point.", "However, in another application, AUV 501a finds its desired position using a combination of acoustic guidance, waypoint navigation and information from various navigation sensors such as an inertial measurement unit, echo sounder, pressure gauge, etc., including communications from guidance system 552.Other systems or methods may be used for finding their desired positions.", "After launch from ROV 550, AUV 501a is configured to communicate with guidance system 552 to determine the position of AUV 501a and find its destination in route.", "The final details, positions, and/or coordinates for finding the desired destination position of AUV 501a may be received, acoustically, from ROV 550.Once AUV 501a lands at its destination on the seabed, the final destination point can be communicated to and/or verified by ROV 550.In one embodiment, the launching of AUVs 501a is performed while surface vessel 510 is still moving in the general direction of the intended seismic survey pattern, while in other embodiments surface vessel 510 remains substantially stationary on the surface.", "In one embodiment, a plurality of AUVs 501a can be launched from ROV 550 at a particular time, such that all AUVs leave the ROV at or near the same time.", "In other embodiments, one or more of the plurality of AUVs 501a are launched at a particular time based upon the intended destination location, such that a plurality of AUVs may remain with the ROV as one or more AUVs are deployed.", "The use of ROV 550 to guide AUVs 501a provides a much faster, reliable, and accurate method to position seismic AUVs on the seabed than current techniques.", "Once all or substantially all of AUVs 501a have been launched from ROV 550, second plurality of AUVs 501b that are stored in cage 520 can be deployed in a similar manner.", "In another embodiment, a second plurality of AUVs 501b can be launched from cage 520 at or near the same time that a first plurality of AUVs 501a are launched from ROV 550.In one embodiment, AUVs 501b are launched directly from cage 520 based on communications with guidance system 552.In another embodiment, ROV 550 moves towards the position of cage 520 and retrieves AUVs 501b and stores them in skid 530 of ROV 550 after the first plurality of AUVs 501a have been deployed.", "In one embodiment, transfer receptacles 354 on ROV 550 (see FIG.", "3) engage with cage 520 to transfer AUVs 501b or trays of AUVs 501b to the ROV 550.Robotic arm 310 on ROV 550 may or may not be used to facilitate the transfer of AUVs 501b and/or the positioning of AUVs on the seabed.", "In one embodiment, skid 530 and/or cage 520 may comprise one or more conveyor belts or lateral moving mechanisms that transfer the AUVs from cage 520 to ROV 550.As shown in FIG.", "6, once all of second plurality of AUVs 501b have transferred from cage 520, cage 520 is raised to surface 1 by surface vessel 510 to obtain a new set of AUVs.", "Meanwhile, first plurality of AUVs 501a have been deployed to seabed 3 or are in transit to their destinations, and second plurality of AUVs 501b (previously transferred from cage 520) remain stored in ROV 550 while awaiting launch instructions from ROV 550.In one embodiment (not shown), by the time the second plurality of AUVs 501b have been deployed from ROV 550, cage 520 has been re-lowered to a location proximate the ROV (or a separate location to which the ROV may travel to) with a new set of AUVs, which can be deployed in a similar manner as described above.", "This process, of lowering and raising cage 520 with a new plurality of AUVs and the AUVs being deployed by ROV 550, can be repeated numerous times until the required amount of AUVs have been positioned and/or the survey has been completed.", "Because the launching of AUVs is performed while surface vessel 510 is still moving in the general direction of the intended seismic survey pattern, a great number of AUVs can be deployed fast and accurately.", "While ROV 550 can be deployed by vessel 510, other vessels (such as shooting vessels or unmanned surface vessels) can also deploy ROV 550 before or near the time that cage 520 is lowered.", "Thus, a first surface vessel may deploy the ROV and a second surface vessel may deploy the cage and multiple pluralities of AUVs.", "In other embodiments, multiple cages or ROVs can be used to provide even faster deployment times for the AUVs.", "In one embodiment, the AUVs may be configured to also communicate with acoustic positioning system 511 on the deployment vessel 510 in addition to ROV 550, which may function as a backup communications system.", "Once the survey is complete, or a particular portion of the survey is complete such that a group of AUVs no longer needs to remain on the seabed, a signal is selectively provided to a plurality of AUVs by ROV 550 to initiate recovery.", "The selected AUVs may be chosen from a given row or column if that type of arrangement is used.", "In one embodiment, the recovery is performed in a reverse manner as the launch, as described above.", "For example, each selected AUV communicates with ROV 550 and moves toward ROV 550 using an INS or acoustic communications system on the AUV.", "In another embodiment, ROV 550, a surface vessel, or a subsea station (such as cage 520) may be configured to send acoustic signals to the returning AUVs to guide them to the desired position.", "In one embodiment, the AUVs are guided into skid 530 for recovery.", "In other embodiments, robotic arm 310 is used to grab or secure a particular AUV and insert it into skid 530.In still another embodiment, when selected AUVs are instructed to leave their recording locations, they may be programmed to go to a desired rendezvous point where they will be collected by ROV 550 at a later time.", "In still other embodiments, ROV 550 is moved towards each AUV (or selected AUVs in which their power has been depleted) to grab the AUV and insert it into skid 530.Once a significant amount of AUVs has been recovered in ROV 550, the ROV 550 can transfer the AUVs individually or in groups (via trays or conveyors) to cage 520.Once full, cage 520 can be raised to a surface vessel (which may or may not be the same deployment vessel) while ROV 550 recovers additional AUVs from the seabed.", "In still other embodiments, the plurality of AUVs are configured to travel directly to a lowered cage or other subsea station without assistance by the ROV.", "In other embodiments, ROV 550 is not configured with a guidance system and/or does not communicate with the AUVs for positioning or guidance.", "Rather, each AUV communicates with acoustic positioning system 511 on surface vessel 510 or a separate surface vessel (see FIGS.", "8-10) or another acoustic positioning system deployed in the ocean (such as an underwater base station, cage 520, or another AUV, which may be connected to a surface vessel via a wire).", "In this embodiment, ROV 550 is still configured to hold a plurality of AUVs and transfer AUVs from cage 520 to skid 530, but all communications between and directions to the AUVs are performed through a separate communications system.", "Likewise, for recovery of the AUVs, ROV 550 can grab the AUVs and place them in skid 530 and/or cage 520 for ultimate recovery to the surface vessel.", "While in this embodiment the ROV does not directly provide guidance to the positioning of the AUVs, the use of an ROV for deployment and/or recovery with a separate cage 520 provides a significant increase in deployment and recovery speeds as opposed to current techniques.", "Further, this eliminates the need for powerful batteries in the AUVs that are able to be deployed to or near the seabed from a surface vessel and travel back to the surface vessel from the seabed.", "Still further, this eliminates the need for a complicated retrieval system on the surface vessel to retrieve the AUVs from the ocean after the seismic survey has bee completed.", "Still further, this eliminates the need for the AUVs to directly communicate with a surface vessel, which takes more time, power, and is not as accurate as communicating with a local ROV or other underwater vehicle or station that is more proximate to the AUVs.", "FIG.", "7 illustrates another embodiment for the recovery of AUVs using an ROV.", "This system is similar to the system described in FIG.", "5, but utilizes a station or cage 720 that is used in addition to or as replacement of skid 530 of ROV 550.Cage 720 is configured to sit on seabed 3 and store a plurality of AUVs 701b.", "In this embodiment, guidance of AUVs 701a is still performed through guidance system 552 of ROV 550, as described above in relation to FIGS.", "5 and 6.In this embodiment, one or more cages 720 can be deposited on the seabed before or after the deployment of AUVs 701a on or near the seabed (such as described in FIGS.", "5 and 6).", "Once the survey is complete, or a particular portion of the survey is complete such that a group of AUVs 701a no longer needs to remain on the seabed, a signal is provided to a plurality of AUVs 701a to initiate recovery.", "The AUVs 701a are then guided to cage 720 for temporary storage as stored AUVs 701b within cage 720.The AUVs can be guided via acoustic positioning system 511, guidance system 552, or even a beacon or array of transmitters (not shown) on cage 720, which may be similar to acoustic system 315 and/or 470 of ROV (see FIGS.", "3 and 4).", "In other embodiments, the ROV may also place the AUVs into cage 720, which may be useful if any of the AUVs do not have enough power to return to the cage.", "When desired, one or more ROVs can retrieve cages 720 and attach them to line 522 for recovery to a surface vessel.", "FIG.", "8 illustrates another system for using an ROV to assist in the guidance of AUVs on or near the seabed.", "This system is similar to the system described in FIG.", "5, but utilizes a second vessel 820 for communications with ROV 550.In one embodiment, vessel 820 is an unmanned surface vessel (“USV”), and in some embodiments it may be a floating buoy with a communications system.", "In one embodiment, ROV 550 is connected to surface vessel 510 via umbilical system 512.In other embodiments, ROV 550 may be connected to USV 820 by umbilical system 512.USV 820 may be utilized in addition to or as a replacement of surface vessel 510 for communications with ROV 550 and/or the plurality of AUVs.", "In one embodiment, USV 820 is equipped with acoustic positioning system 821, which may be similar to the acoustic positioning system 511 located on deployment vessel 510.USV 820 is configured to communicate with deployment vessel 510 with a variety of communications, preferably wirelessly.", "Because USV 820 may be positioned closer to ROV 550 than the deployment vessel 510, USV 820 may provide faster and better communications with ROV 550.Another embodiment uses both deployment vessel 510 and USV 820 to communicate with ROV 550 and/or the plurality of AUVs.", "The use of two transducers or acoustic positioning systems that communicate with ROV 550 from the different vessels (as opposed to one) increases the electrical and acoustic redundancy of the communications based on two independent measurements.", "The dual system uses both transducers from the vessels to measure the position of one single target transponder (located on the ROV) by separately controlling the beam forming and phase measurement for each system in parallel.", "This provides greater accuracy of the AUV positioning and quality control.", "A more accurate position of ROV 550 provides better data and accuracy to position the AUVs at the desired locations.", "In another embodiment, a plurality of USVs may be used to communicate with ROV 550 to provide still better accuracy regarding the location of ROV 550.In other embodiments, one or more surface buoys (not shown) may be used in addition to or as a replacement of USV 820 for communication with ROV 550.In still other embodiments, one or more underwater stations or AUVs (not shown) may be used in addition to or as a replacement of USV 820 for communication with ROV 550.In one embodiment, ROV 550 may be deployed or launched by USV 820 instead of deployment vessel 510.In still another embodiment, AUVs may be configured to communicate with both USV 820 (or another surface vessel or device) and vessel 510.In still other embodiments, the AUVs may be configured to communicate with (and be guided and/or instructed by) cage 520 if the cage is equipped with the necessary communications equipment.", "In another embodiment, an AUV is dropped from an ROV (such as from the bottom of the ROV or a skid of the ROV) while the ROV is moving.", "Thus, the ROV need not actually touch the bottom of the seabed during deployment of the AUVs Likewise, the AUVs can be recovered to the moving ROV while the ROV is in motion above the seabed.", "In other embodiments, the AUVs can be recovered to a skid or cage that is located above the seabed and as it is moved laterally along with a surface vessel.", "In still other embodiments, a plurality of ROVs and/or a plurality of skids or cages can be towed by one or more surface vessels to deploy and/or recover a plurality of AUVs.", "FIG.", "9 illustrates another embodiment for the recovery of AUVs using an underwater vehicle, which may or may not be an ROV.", "Similar to the system described in FIG.", "8, this system uses second surface vehicle 820 to help guide the AUVs during subsea operations.", "Basket or cage 960 is configured to be lowered (and raised) by surface vessel 510 to a subsea position, which may be on or near seabed 3, in the middle of the ocean, or near the surface of the ocean a relatively short distance from surface 1.Cage 960 may be configured with communications system 962 and propulsion system 964, while in some embodiments cage 960 may not have any communications system or propulsion system.", "Cage 960 is configured to hold a plurality of AUVs 501 in the cage, which may be held in the cage by any number of arrangements, whether by conveyor, conveyor belt, chain, carousel, skid, basket, etc.", "As in earlier embodiments, any AUVs may be positioned in the cage while on the back deck of surface vessel 510.Communications system 962 may be configured to communicate with other communications systems 511, 821, and 952, as well as the communications systems on each of the plurality of AUVs 501.In some embodiments, cage 960 may have one or more transmitters or pingers configured to transmit acoustic signals (or pings) that may be detected by the AUVs for deployment or retrieval operations.", "Propulsion system 964 may include any number of thrusters, propellers, nozzles or similar devices known to those of skill in the art to move a subsea basket or station from a first subsea position to a second subsea position, including any such propulsion system that may be used on an ROV as is known in the art.", "Underwater vehicle 950 is configured to be lowered by vessel 510 to a subsea position, which may be on or near seabed 3, in the middle of the ocean, or near the surface of the ocean a relatively short distance from surface 1.While in one embodiment underwater vehicle 950 is an ROV, it need not be an ROV.", "For example, underwater vehicle 950 need not have an arm and it may be a cage or AUV configured with communications system 952 and propulsion system 954.Underwater vehicle 950 may be coupled to surface vessel 510 via wire or umbilical cable 912, which in some embodiments may allow data and power to be communicated to underwater vehicle 950 so that it can stay subsea during longer periods of time and have faster data rates.", "In some embodiments, communications systems 952 is an acoustic guidance system that may be configured to interact with acoustic system 511 of first vessel 510, acoustic system 821 of second vessel 820, acoustic system 962 of cage 960, and/or the plurality of AUVs 501.While the underwater vehicle may have or be coupled to a skid or cage to hold a plurality of AUVs, such a holding assembly is not necessary in this embodiment.", "The system described in FIG.", "9 operates substantially similar to the prior embodiments with underwater vehicle 950 providing some guidance to the deployment of AUVs 501 from cage 960 and/or to the seabed.", "In the embodiment shown in FIG.", "9, however, underwater vehicle 950 does not physically retrieve, grab, or move any AUVs.", "Instead, underwater vehicle 950 is used solely as a positioning and/or guidance system for the deployment and/or retrieval of the plurality of AUVs.", "In some embodiments, underwater vehicle 950 and/or second vessel 820 may actively travel closer to one or more deployment locations for increased communications accuracy and/or speed to the plurality of AUVs in that general deployment location.", "This allows the AUVs to be positioned on the seabed with enhanced accuracy.", "The configuration described in relation to FIG.", "9 allows cage 960 to be raised back to surface vessel to obtain a second plurality of AUVs while the first plurality of AUVs are being deployed by another vehicle, such as by second vessel 820 or underwater vehicle 950, and allows increased communications efficiency and accuracy with the AUVs during deployment to the seabed.", "In other words, a separate vehicle may be positioned more proximate to the intended deployment position on the seabed or near the AUVs as they are deploying to the seabed, whether the second vehicle is second vessel 820 or underwater vehicle 950.Thus, a communications system on each AUV must be configured to interface with a communications system on each or both of surface vessel 820 and/or underwater vehicle 950, and in one embodiment such a communications may be one of USBL, iSBL, iUSBL, or any combination thereof.", "In one embodiment, the plurality of AUVs may be launched from cage 960 based upon communications provided to the plurality of AUVs from one of many potential locations, including first surface vessel 510, second surface vessel 820, underwater vehicle 950, or cage 960.The plurality of AUVs may be launched individually, sequentially, or near simultaneously.", "In one embodiment, once one or more of the plurality of AUVs leaves cage 950 and arrives at a second subsea position, a second station or vessel may take over the guidance and/or positioning of the AUVs to land at the intended seabed location.", "In other words, while a first vehicle or device (such as cage 960 and/or first vessel 510) may instruct the AUVs to leave the cage, a second vehicle (such as underwater vehicle 950 or second vessel 820) may instruct, guide, and/or position the AUVs to their final seabed destination.", "In some embodiments, for increased positioning accuracy and faster communications, second vessel 820 may be positioned proximate to a subsea position substantially where the AUVs are to be deployed (such as being located on the water surface at a point substantially over one or more of the intended deployment locations of the AUVs) and/or underwater vehicle 950 may be positioned proximate to the position of the deployed AUVs (which may be near the seabed).", "Each of the plurality of AUVs may have a predetermined location on seabed 3 as to which it will land, couple with the seabed, and record seismic signals during any seismic survey.", "During any retrieval operations, a recovery station may be utilized, which is in one embodiment the same as or substantially similar to cage 960.In one embodiment, one of the surface vessels or underwater vehicle 950 provides a communication to each of the selected AUVs to wake up and return to a recovery station and/or cage after the seismic survey has been completed.", "Such communications may include the subsea location of the recovery position and/or cage.", "In some embodiments, recovery station and/or cage 960 may include a homing array and/or a plurality of transmitters or pingers that is configured to emit a plurality of acoustic signals or pings to which the plurality of AUVs may be guided to during retrieval operations, which allows for increased accuracy and/or positioning of the AUVs to the cage when in a close proximity to the cage.", "Such a system may be similar to the acoustic guidance system and/or communications system described in relation to FIG.", "4 or the systems disclosed in Publication No.", "WO 2014/147165 and US Publication No.", "2014/0301161, each incorporated herein by reference.", "In some embodiments, multiple cages may be used at the same time, such that a greater number of AUVs may be deployed and/or retrieved at a given time.", "FIG.", "10 illustrates another embodiment for the recovery of AUVs using an underwater vehicle.", "This system is similar to the system described in FIG.", "9, but does not use a second subsea vehicle besides cage 960.Similar to the systems described in FIGS.", "8 and 9, this system uses second surface vehicle 820 to help guide the AUVs during one or more subsea operations.", "Basket or cage 960 is configured to be lowered (and raised) by surface vessel 510 to a subsea position, which may be on or near seabed 3, in the middle of the ocean, or near the surface of the ocean a relatively short distance from surface 1.In one embodiment, cage 960 is substantially similar to the cage described in relation to FIG.", "9, and thus may or may not have communications system 962 and propulsion system 964.Like the system described in relation to FIG.", "9, it may be configured with a homing system or set of transmitters or pingers.", "In one embodiment, cage 960 is lowered to a first subsea position with a plurality of AUVs.", "One or more of the plurality of AUVs may be launched from cage 960 based on communications from cage 960, first vessel 510, or second vessel 820.In one embodiment, second vessel 820 travels to a surface position proximate to the intended deployment position of the AUVs.", "Once the AUVs have left the cage and have travelled to a first subsea position and/or are in route to a subsea position, first vessel 510 and/or second vessel 820 may provide communications to the AUVs to actively guide and/or position them to a predetermined destination on the seabed.", "The cage may raised and filled with a new set of AUVs, which may be deployed again in a similar manner.", "During retrieval operations, the AUVs may be sent a signal to wake-up and/or move to a subsea recovery position, which may be on or near the seabed or proximate to cage 960.Such communications may be provided to the AUVs by cage 960, first vessel 510, or second vessel 820.In one embodiment, each AUV has a homing array that guides the AUV towards one or more pings or signals emitting from cage 960.In some embodiments, multiple cages may be used for faster deployment and/or recovery of the AUVs.", "FIG.", "11 illustrates one embodiment of a method 1100 for assisting with the deployment of a plurality of seismic AUVs with an ROV or other underwater vehicle.", "In an embodiment, the method includes providing at least one ROV on or near the seabed, as shown in block 1102.In one embodiment, the ROV may be lowered by a first surface vessel and may or may not comprise a first plurality of AUVs (such as being located within a skid of the ROV).", "The ROV has a guidance system for communicating with a plurality of AUVs.", "The method further includes providing at least one surface vessel to communicate with the at least one ROV, as shown in block 1104.The surface vessel can be a deployment vessel, a shooting vessel, an unmanned surface vessel (USV), or other surface vessels or stations.", "The vessel may have an acoustic positioning system that is configured to communicate with the ROV, but in some embodiments may only be connected to the ROV via a wire and/or umbilical system.", "In one embodiment, the ROV is configured to determine its subsea position based upon acoustic communications with the surface vessel.", "In some embodiments, the acoustic positioning system of the surface vessel can also communicate with a plurality of AUVs.", "The method further includes providing at least one subsea station configured to hold a plurality of AUVs, as shown in block 1106.In one embodiment, the subsea station is a basket or cage filled with a second plurality of AUVs that is deployed from the same vessel that provides or deploys the ROV.", "In other embodiments, a separate vessel deploys the subsea station.", "The subsea station may be deployed on the seabed (which may be preferred for stability reasons) or merely hang on a connecting wire from the surface vessel a certain distance above the seabed or beneath the surface.", "In still other embodiments, the subsea station may be connected to an underwater vehicle, such as a skid.", "In one embodiment, the ROV is deployed first on or near the seabed, while in another embodiment the subsea station is deployed first on or near the seabed.", "The method further includes positioning a plurality of AUVs on the seabed based on communications with the ROV, as shown in block 1108.The plurality of AUVs may be those located on the subsea station and/or those located on the ROV itself.", "The first plurality of AUVs may be deployed first or the second plurality of AUVs may be deployed first.", "In some embodiments, the first plurality of AUVs (within the skid) are deployed first and then a portion of the second plurality of AUVs are transferred to the ROV and then subsequently deployed when the ROV is in a position proximate to the intended destination location.", "In other embodiments, the AUVs are launched directly from the subsea station based on communications provided by the ROV.", "In one embodiment, a guidance system on the ROV interacts with an acoustic communications system or INS on each AUV to provide the AUV directions and coordinates as to the intended deployment location.", "The AUVs may be deployed along a predetermined pattern, e.g., a regular grid based on predetermined coordinates.", "In one embodiment, a particular AUV is selectively instructed to wake up and travel to a seabed destination based on the AUV's propulsion system and guidance system receiving commands from the ROV's guidance system.", "An AUV may be deployed one at a time until it arrives at its seabed location, or a plurality of AUVs may be deployed simultaneously or near the same time.", "In some situations, the ROV may travel to the general area proximate to the seabed destination with a group of AUVs and then deploy the relevant AUVs.", "The ROV may verify the positions of the AUVs and confirm that they are located at the correct locations in the predetermined grid.", "In one embodiment, the method further comprises providing a third plurality of AUVs proximate to the ROV, as shown in block 1110.The third plurality of AUVs may be lowered by the same subsea station (such as the same basket or cage) that delivered the second plurality of AUVs.", "In other embodiments, a separate vessel or station may deliver the third plurality of AUVs proximate to a location proximate to the ROV or to the intended AUV seabed destination.", "The method further comprises positioning the third plurality of AUVs on or near the seabed based on communications with the ROV, as shown in block 1112.This positioning step may, but not necessarily, be performed in the same way as described in step 1108.Once the AUVs are in place and operational, the AUVs are ready to acquire and record seismic data.", "During the recordal of seismic data, the ROV may confirm that the AUVs are active and recording data, along with the status of other components (e.g., power unit capacity, data storage capacity, etc.).", "If a particular AUV needs to be replaced and/or is no longer working, the ROV may retrieve the problematic AUV and replace it with another AUV that is located in the ROV skid.", "FIG.", "12 illustrates one embodiment of a method 1200 for assisting with the recovery of a plurality of seismic AUVs with an ROV or other underwater vehicle.", "In an embodiment, the method includes providing at least one ROV on or near the seabed, as shown in block 1202.The ROV may or may not comprise a skid that is configured to hold a plurality of AUVs.", "The ROV has a guidance system for guiding and/or communicating with a plurality of AUVs.", "The method further includes providing at least one subsea recovery station configured to hold a plurality of AUVs, as shown in block 1204.In one embodiment, the subsea station is a cage or basket that is deployed from a surface vessel, and may or may not be the same station used to deploy the AUVs to the seabed.", "In other embodiments, a separate vessel provides the subsea recovery station.", "In other embodiments, a plurality of subsea stations has been positioned on the seabed in proximity to one or more groups of AUVs.", "In still another embodiment, the subsea station is a skid or other holding device that is part of or coupled to an underwater vehicle, such as the ROV.", "In some embodiments, the subsea station is not positioned near the seabed but is merely positioned in the body of water at some distance beneath the vessel and/or water surface.", "The method further includes communicating with a plurality of AUVs on or near the seabed, as shown in block 1206.These AUVs may or may not have been previously positioned by an ROV.", "In one embodiment, the AUVs are located on the seabed and need to be recovered to the surface for data recovery after their recording of seismic waves.", "In one embodiment, the ROV communicates with each of (or a portion of) the plurality of AUVs, in which a particular AUV is selectively instructed to wake up and travel to a subsea recovery destination based on the AUV's propulsion system and guidance system receiving commands from the ROV's guidance system.", "The method further includes recovering and/or positioning a plurality of AUVs into at least one subsea recovery station based on assistance by the ROV, as shown in block 1208.In one embodiment, the assistance is based on acoustic communications between the ROV and the plurality of AUVs.", "In this embodiment, a guidance system on the ROV interacts with an acoustic communications system or INS on each AUV to provide the AUV directions and coordinates as to the intended subsea recovery location, which may be a single spot on the seabed, within the ROV, or in the subsea station.", "In other instances, the ROV assistance is the grabbing or securing of the plurality of AUVs by the ROV, such as by a robotic arm, and the placement of the AUVs in the intended subsea station.", "These communicating and positioning steps can be repeated multiple times until all of the AUVs are recovered in one or more subsea stations.", "In one embodiment, the plurality of AUVs and/or the plurality of subsea stations are recovered to a surface vessel.", "FIG.", "13 illustrates another embodiment of a method 1300 for assisting with the deployment of a plurality of seismic AUVs.", "In one embodiment, a subsea station with a plurality of AUVs is launched from a first surface vessel to a subsea position, as shown in block 1302.The subsea station may be a cage or basket or other similar structure configured to hold and deploy a plurality of AUVs subsea, while in other embodiments it may be coupled to an underwater vehicle.", "The subsea position may be on or near the bottom of the ocean, in the middle of the ocean, or near the surface of the ocean.", "The subsea station may or may not have an acoustic guidance system and/or a propulsion system.", "One or more of the plurality of AUVs are then launched from the subsea station based upon communications provided to the one or more plurality of AUVs from one of various locations or devices, including a first surface vessel, a second surface vessel, an underwater vehicle (such as an ROV), or the subsea station itself, as shown in block 1304.The plurality of AUVs may be launched individually, sequentially, or near simultaneously.", "In one embodiment, the AUVs leave the subsea station and travel to a second subsea position to await further commands.", "The second subsea location may be a subsea position near the station, near a separate vessel or vehicle, or on or near a seabed position.", "A separate vehicle may be positioned to a position proximate to the one or more launched AUVs and/or to a position where the AUVs are to be deployed on the seabed, as shown in block 1306.In some embodiments, a second surface vehicle or vessel (such as vessel 820) may be positioned proximate to a subsea position where the AUVs are to be deployed.", "Likewise, an underwater vehicle (such as a ROV) may be positioned proximate to the position of the deployed AUVs.", "Once the AUVs have been launched from the subsea station, the one or more AUVs are guided to a predetermined seabed location for the recording of seismic data, as shown in block 1308.The trajectory of the AUV may be adjusted in real time based on received communications.", "In one embodiment, once one or more of the plurality of AUVs leaves the subsea station and arrives at a second subsea position, a second vehicle, station, or vessel may take over and/or assist with the guidance and/or positioning of the AUVs to land at a seabed location.", "In other words, while a first vehicle or device (such as the basket or first surface vessel) may instruct the AUVs to leave the subsea station, a second vehicle or device (such as an underwater vehicle or second vessel) may instruct, guide, and/or position the AUVs to their final seabed destination.", "In some embodiments, the position of the AUV may be determined based upon communications with multiple systems, such as by one or more surface vehicles, an underwater vehicle, and/or the subsea station.", "In some embodiments a single AUV is launched from the subsea station and deployed to a seabed location, while in other embodiments a plurality of AUVs are launched from the subsea station and deployed to a plurality of seabed locations.", "While the first plurality of AUVs is being deployed to the seabed (and after the AUVs have left the subsea station), the subsea station is raised back to the first surface vessel for transferring a second plurality of AUVs to the subsea station.", "Similar to the prior steps, the second plurality of AUVs may be launched from the subsea station (based on instructions by a first communications system) and once freely travelling in water may be guided and/or positioned to another subsea position (such as a predetermined location on the seabed) by a second communications system.", "After the seismic survey is completed, which may be days or months after being positioned on the seabed, the plurality of AUVs must be retrieved to a surface vessel.", "In some embodiments, the method 1300 includes various retrieval operations for the plurality of deployed AUVs.", "For example, method 1300 may include recovering one or more of the deployed AUVs at a subsea position, as shown in block 1310.In one embodiment, the plurality of AUVs are instructed to travel to a first subsea position from each of their deployed seabed locations, which may be on or near the seabed or proximate to a subsea recovery station.", "Such a position may be near the seabed or near the surface of the body of water.", "In one embodiment, a separate vehicle or station (such as first or second surface vessel, underwater vehicle, or the recovery basket or station) communicates the coordinates of the subsea position to the plurality of AUVs, along with any necessary wake up commands and other instructions.", "In some embodiments, the AUVs may travel to a position near the intended recovery position (or underwater vehicle, cage, or basket) or the recovery station may travel to a position proximate to the plurality of AUVs.", "Method 1300 may further include retrieving the one or more AUVs into a subsea recovery station, as shown in block 1312.The subsea recovery station may or may not be the same subsea station used to deploy the AUVs, and it may include a cage, basket, or similar holding structure, and may or may not be coupled to an underwater vehicle.", "For example, once the AUVs are in a position proximate to the recovery station, the AUVs are instructed to return to the recovery station.", "In one embodiment, one of the surface vehicles, an underwater vehicle, and/or recovery station itself (such as a basket) communicates the coordinates of the recovery position and/or recovery station to the plurality of AUVs.", "In some embodiments, the AUVs are guided to the recovery station by a homing array that detects one or more pings or acoustic signals emitting from the recovery station.", "Once the AUVs are loaded onto the subsea recovery station, it may be raised back to a recovery vessel (which may or may not be the same vessel as the deployment vessel), the AUVs transferred from the recovery station to the vessel, and an empty recovery station returned to a subsea position for loading of additional AUVs.", "Steps 1310 and 1312 may be repeated until the necessary amount of AUVs has been retrieved from the seabed.", "In some embodiments, multiple recovery stations, such as multiple baskets, may be used simultaneously.", "In one embodiment, the AUVs are deployed from a subsea station from a position substantially near the ocean surface while the AUVs are retrieved into a subsea station on or substantially near the seabed.", "All of the methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure.", "While the apparatus and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention.", "In addition, modifications may be made to the disclosed apparatus and components may be eliminated or substituted for the components described herein where the same or similar results would be achieved.", "All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope, and concept of the invention.", "Many other variations in the configurations of a node and the wireless systems on the node and/or vessel are within the scope of the invention.", "For example, the AUV may be of any configuration, and may be designed to couple to the seabed or merely near the seabed.", "In one embodiment, a first vessel may act as a deployment vessel, a second vessel may act as a retrieval vessel, and a third vessel may act as the seismic source/shooting vessel.", "As another example, the ROV may not comprise a robotic arm and may simply act as a deployment and/or retrieval guide by the use of its communications system and/or acoustic guidance system.", "In other embodiments, a subsea station, cage, or other underwater vehicle may be used to provide commands and/or acoustic communications with the plurality of AUVs.", "In still other embodiments, the AUVs may be deployed from a cage and retrieved to that cage without the use of a ROV.", "It is emphasized that the foregoing embodiments are only examples of the very many different structural and material configurations that are possible within the scope of the present invention.", "Although the invention(s) is/are described herein with reference to specific embodiments, various modifications and changes can be made without departing from the scope of the present invention(s), as presently set forth in the claims below.", "Accordingly, the specification and figures are to be regarded in an illustrative rather than a restrictive sense, and all such modifications are intended to be included within the scope of the present invention(s).", "Any benefits, advantages, or solutions to problems that are described herein with regard to specific embodiments are not intended to be construed as a critical, required, or essential feature or element of any or all the claims.", "Unless stated otherwise, terms such as “first” and “second” are used to arbitrarily distinguish between the elements such terms describe.", "Thus, these terms are not necessarily intended to indicate temporal or other prioritization of such elements.", "The terms “coupled” or “operably coupled” are defined as connected, although not necessarily directly, and not necessarily mechanically.", "The terms “a” and “an” are defined as one or more unless stated otherwise.", "The terms “comprise” (and any form of comprise, such as “comprises” and “comprising”), “have” (and any form of have, such as “has” and “having”), “include” (and any form of include, such as “includes” and “including”) and “contain” (and any form of contain, such as “contains” and “containing”) are open-ended linking verbs.", "As a result, a system, device, or apparatus that “comprises,” “has,” “includes” or “contains” one or more elements possesses those one or more elements but is not limited to possessing only those one or more elements.", "Similarly, a method or process that “comprises,” “has,” “includes” or “contains” one or more operations possesses those one or more operations but is not limited to possessing only those one or more operations." ] ]
Patent_15874270
[ [ "ROTARY ENCODER WITH SHIELDED MAGNET", "A magnetic set-up for use in a rotary encoder is disclosed.", "The set-up includes a permanent magnet arrangement including at least one permanent magnet, which is rotatable with respect to a rotation axis, and a soft magnetic sleeve encompassing the rotation axis and thus the permanent magnet arrangement for shielding against external magnetic fields.", "The at least one permanent magnet includes a through-hole, which extends along the rotation axis, so that the permanent magnet fully extends around the rotation axis." ], [ "1.A rotary encoder, the set-up comprising: a permanent magnet arrangement including at least one permanent magnet, which is rotatable with respect to a rotation axis; and a soft magnetic sleeve encompassing the rotation axis and thus the permanent magnet arrangement for shielding against external magnetic fields; a shaft, which is rotatable with respect to a rotation axis and mechanically coupled to the permanent magnet arrangement to ensure a common rotation, wherein the at least one permanent magnet includes a through-hole, which extends along the rotation axis, so that the permanent magnet fully extends around the rotation axis, and wherein the soft magnetic sleeve is formed by a cavity arranged in the shaft, the cavity extending, along the rotation axis, into the shaft from a front side of the shaft.", "2.The rotary encoder of claim 1, wherein the at least one permanent magnet is substantially rotationally symmetric with respect to the rotation axis.", "3.The rotary encoder of claim 1, wherein the permanent magnet arrangement is substantially symmetric with respect to a symmetry plane, to which the rotation axis is perpendicular.", "4.The rotary encoder of claim 1, wherein the permanent magnet arrangement has a centroid that is located within the through-hole at the rotation axis.", "5.A rotary encoder, the set-up comprising: a permanent magnet arrangement including at least one permanent magnet, which is rotatable with respect to a rotation axis; and a soft magnetic sleeve encompassing the rotation axis and thus the permanent magnet arrangement for shielding against external magnetic fields; a shaft, which is rotatable with respect to a rotation axis and mechanically coupled to the permanent magnet arrangement to ensure a common rotation, wherein the at least one permanent magnet includes a through-hole, which extends along the rotation axis, so that the permanent magnet fully extends around the rotation axis, and wherein the soft magnetic sleeve is slipped over the shaft.", "6.The rotary encoder of claim 5, wherein a front side of the shaft adjoins the permanent magnet arrangement.", "7.The rotary encoder of claim 6, wherein the shaft includes a cavity, which extends into the shaft from a front side of the shaft along the rotation axis.", "8.The rotary encoder of claim 7, wherein the permanent magnet arrangement has an outer diameter and the cavity included in the shaft has an axial length equal to or greater than the outer diameter of the permanent magnet arrangement.", "9.The rotary encoder of claim 5, wherein the at least one permanent magnet is substantially rotationally symmetric with respect to the rotation axis.", "10.The rotary encoder of claim 5, wherein the permanent magnet arrangement is substantially symmetric with respect to a symmetry plane, to which the rotation axis is perpendicular.", "11.The rotary encoder of claim 5, wherein the permanent magnet arrangement has a centroid that is located within the through-hole at the rotation axis.", "12.A rotary encoder, comprising: a permanent magnet arrangement including at least one permanent magnet, which is rotatable with respect to a rotation axis; and a soft magnetic sleeve encompassing the rotation axis and thus the permanent magnet arrangement for shielding against external magnetic fields; wherein the at least one permanent magnet includes a through-hole, which extends along the rotation axis, so that the permanent magnet fully extends around the rotation axis, wherein the sleeve has a collar, which is inwardly bent to the rotation axis, and wherein a front side of the permanent magnet arrangement adjoins a back side of the collar.", "13.The rotary encoder of claim 12, wherein the at least one permanent magnet is substantially rotationally symmetric with respect to the rotation axis.", "14.The rotary encoder of claim 12, wherein the permanent magnet arrangement is substantially symmetric with respect to a symmetry plane, to which the rotation axis is perpendicular.", "15.A rotary encoder comprising: a permanent magnet arrangement including at least one permanent magnet, which is rotatable with respect to a rotation axis and includes a through-hole, which extends along the rotation axis, so that the permanent magnet fully extends around the rotation axis; a soft magnetic sleeve encompassing the rotation axis and thus the permanent magnet arrangement for shielding external magnetic fields; and a magnetic field sensor located within the through-hole on the rotation axis, wherein the permanent magnet arrangement is substantially symmetric with respect to a symmetry plane, to which the rotation axis is perpendicular, and wherein the magnetic field sensor is located at the intersection of the symmetry plane and the rotation axis.", "16.The rotary encoder of claim 15, wherein the permanent magnet arrangement has a centroid that is located within the through-hole, and wherein the magnetic field sensor is located in the centroid.", "17.The rotary encoder of claim 15, wherein the at least one permanent magnet is substantially rotationally symmetric with respect to the rotation axis.", "18.The rotary encoder of claim 15, wherein the permanent magnet arrangement is substantially symmetric with respect to a symmetry plane, to which the rotation axis is perpendicular.", "19.The rotary encoder of claim 15, wherein the permanent magnet arrangement has a centroid that is located within the through-hole at the rotation axis.", "20.The rotary encoder of claim 15, wherein the magnetic field sensor includes one or more sensor elements included in one chip package." ], [ "<SOH> BACKGROUND <EOH>For operation in harsh environments, it is good practice to use angle sensors based on magnetic principles.", "They cover a large temperature range from 50 degrees to 170 degrees Celsius, show practically no wear, and are robust against many kinds of contaminations.", "Automotive applications reach from small angular excursions of a few (angular) degrees (as used, e.g., in torque measurement) to medium angular excursions of 30 to 120 degrees (as used, e.g., in headlight levelling or throttle valve positioning) to complete 360 degree detection in motor position sensing and even to multi-turn detection for steering wheels.", "Particularly for angle ranges exceeding 180 degrees the most common systems use a small permanent magnet attached to the end surface of the rotating shaft.", "The magnetization is usually perpendicular to the rotation axis thus giving rise to a magnetic field, which is thus predominantly perpendicular to this axis.", "A magnetic field sensor is placed in front of the magnet.", "If the axis rotates the magnetic field also rotates and the rotation can be detected by the magnetic field sensor.", "In practical implementations, the magnetic field generated by the permanent magnet used in the rotary encoder can be distorted by undesired external magnetic fields.", "Without countermeasures such distortion will results in a deteriorated measurement of the angular position or speed of the shaft.", "Thus, there is a need for rotary encoders which have a reduced sensitivity with regard to external magnetic fields in order to improve the accuracy of the encoder." ], [ "<SOH> SUMMARY <EOH>Exemplary embodiments of the present disclosure relate to a magnetic set-up for use in a rotary encoder.", "In accordance with one example of the present disclosure the set-up comprises a permanent magnet arrangement including at least one permanent magnet, which is rotatable with respect to a rotation axis, and a soft magnetic sleeve encompassing the rotation axis and thus the permanent magnet arrangement for shielding against external magnetic fields.", "The at least one permanent magnet includes a through-hole, which extends along the rotation axis, so that the permanent magnet fully extends around the rotation axis.", "Other exemplary embodiments of the present disclosure relate to a rotary encoder.", "In accordance with one example of the present disclosure the rotary encoder comprises a permanent magnet arrangement including at least one permanent magnet, which is rotatable with respect to a rotation axis and includes a through-hole, which extends along the rotation axis, so that the permanent magnet fully extends around the rotation axis.", "A soft magnetic sleeve encompasses the rotation axis and thus the permanent magnet arrangement for shielding against external magnetic fields, and a magnetic field sensor is located within the through-hole on the rotation axis." ], [ "REFERENCE TO RELATED APPLICATION This application is a divisional of U.S. application Ser.", "No.", "14/604,855 filed on Jan. 26, 2015, the contents of which are incorporated by reference in their entirety.", "FIELD The present disclosure generally relates to the field of rotary encoders using magnetic field sensors for detecting the angular position or velocity of a rotating shaft.", "BACKGROUND For operation in harsh environments, it is good practice to use angle sensors based on magnetic principles.", "They cover a large temperature range from 50 degrees to 170 degrees Celsius, show practically no wear, and are robust against many kinds of contaminations.", "Automotive applications reach from small angular excursions of a few (angular) degrees (as used, e.g., in torque measurement) to medium angular excursions of 30 to 120 degrees (as used, e.g., in headlight levelling or throttle valve positioning) to complete 360 degree detection in motor position sensing and even to multi-turn detection for steering wheels.", "Particularly for angle ranges exceeding 180 degrees the most common systems use a small permanent magnet attached to the end surface of the rotating shaft.", "The magnetization is usually perpendicular to the rotation axis thus giving rise to a magnetic field, which is thus predominantly perpendicular to this axis.", "A magnetic field sensor is placed in front of the magnet.", "If the axis rotates the magnetic field also rotates and the rotation can be detected by the magnetic field sensor.", "In practical implementations, the magnetic field generated by the permanent magnet used in the rotary encoder can be distorted by undesired external magnetic fields.", "Without countermeasures such distortion will results in a deteriorated measurement of the angular position or speed of the shaft.", "Thus, there is a need for rotary encoders which have a reduced sensitivity with regard to external magnetic fields in order to improve the accuracy of the encoder.", "SUMMARY Exemplary embodiments of the present disclosure relate to a magnetic set-up for use in a rotary encoder.", "In accordance with one example of the present disclosure the set-up comprises a permanent magnet arrangement including at least one permanent magnet, which is rotatable with respect to a rotation axis, and a soft magnetic sleeve encompassing the rotation axis and thus the permanent magnet arrangement for shielding against external magnetic fields.", "The at least one permanent magnet includes a through-hole, which extends along the rotation axis, so that the permanent magnet fully extends around the rotation axis.", "Other exemplary embodiments of the present disclosure relate to a rotary encoder.", "In accordance with one example of the present disclosure the rotary encoder comprises a permanent magnet arrangement including at least one permanent magnet, which is rotatable with respect to a rotation axis and includes a through-hole, which extends along the rotation axis, so that the permanent magnet fully extends around the rotation axis.", "A soft magnetic sleeve encompasses the rotation axis and thus the permanent magnet arrangement for shielding against external magnetic fields, and a magnetic field sensor is located within the through-hole on the rotation axis.", "BRIEF DESCRIPTION OF THE DRAWINGS The disclosure can be better understood with reference to the following drawings and descriptions.", "The components in the figures are not necessarily to scale; in-stead emphasis is placed upon illustrating the principles of the disclosure.", "More-over, in the figures, like reference numerals designate corresponding parts.", "In the drawings: FIG.", "1 is a schematic illustration of a rotary encoder including a permanent magnet attached to a rotating shaft and a magnetic field sensor; FIG.", "2 is a schematic illustration of a rotary encoder including a ferromagnetic shield for shielding the magnetic field sensor from external magnetic fields; FIG.", "3 illustrates one embodiment of a shielded rotary encoder, in which the magnetic field sensor is placed in the magnetic center of the permanent magnet; FIG.", "4 illustrates another second embodiment of a shielded rotary encoder, in which the ferromagnetic shield is formed by the rotating shaft itself; FIG.", "5 illustrates a further embodiment of a shielded rotary encoder, in which the ferromagnetic shield is fitted on the rotating shaft; FIG.", "6 illustrates an embodiment similar to the embodiment of FIG.", "5, wherein the front side of the shaft facing the permanent magnet includes a cavity; FIG.", "7 illustrates an embodiment similar to the embodiment of FIG.", "5, wherein the ferromagnetic shield has an inward-bent collar adjoining a front side of the permanent magnet; FIG.", "8 illustrates another second embodiment of a shielded rotary encoder similar to the embodiment of FIG.", "7, wherein the permanent magnet is replaced by an assembly including two axially spaced permanent magnets; and FIG.", "9 illustrates an exploded view and the assembly of the rotary encoder of FIG.", "8, wherein a split ring-shaped spacer is arranged between the two permanent magnets.", "DETAILED DESCRIPTION Rotary encoders such as the magnetic angle sensor illustrated in FIG.", "1 may be used to measure the angular position or speed of a rotating shaft 10.Generally, such rotary encoders include at least one permanent magnet 11, which is attached to the rotating shaft 10, and a magnetic field sensor attached to a stator (not shown in FIG.", "1).", "In the present example, the magnetic field sensor is composed of several sensor elements 21 integrated in a silicon die 20, which is also referred to as magnetic field sensor chip.", "However, it should be understood that the specific material of the substrate is arbitrary; it may be a different semiconductor material such as e.g.", "GaAs or it may even by a glass or ceramic substrate which holds the sensor elements.", "Moreover, in some cases it may also be useful to have sensor elements distributed on several substrates, which are, however, arranged in the same sensor package (also referred to as multi-chip package).", "The magnetic field sensor chip 20 is configured to measure the magnetic field (in particular its orientation) of the permanent magnet 11, which rotates with the shaft 10.In particular, the sensor elements 21 may be Hall effect sensor elements (Hall plates), MAG-FETs or magneto-resistive (MR) sensor elements (thin film sensor elements).", "The magnetic field “seen” by the sensor chip 20 mainly depends on the remanent magnetization of permanent magnet 11 and disturbing external magnetic fields.", "For the further discussion, a Cartesian coordinate system is used wherein, without loss of generality, the z-axis is defined to be the rotation axis of the shaft 10 (and the magnet 11); the x-axis and the y-axis define the plane (i.e.", "the xy-plane), in which the sensor elements 21 of the magnetic field sensor chip 20 are situated.", "In other words, the magnetic field sensor chip 20 is configured to measure two orthogonal components Hx and Hy of magnetic field H. That is, the magnetic field H is assumed to be a vector in the xy-plane (H=[Hx, Hy]); any field component Hz parallel to the rotation axis (z-axis) is considered negligible or constant (i.e.", "not depending on the angular position of the shaft 10) at the rotation axis, where the sensor chip 20 is located.", "The angular position φ (with respect to the direction of the x-axis) to be measured may then be determined as follows: tan (φ)=Hy/Hx.", "In different set-ups, the magnetic field sensors may be placed distant from the z-axis (rotation axis and measure the field component Hz to obtain information about the angular position of the permanent magnet.", "As indicated above, the magnetic field sensor chip measures the magnetic field H present at the position of the sensor chip 20 (i.e.", "at the spatial coordinates [0, 0, 0]), wherein the effective magnetic field H is a superposition of the magnetic field caused by the permanent magnet 11 and (undesired) external magnetic fields, which distort the desired magnetic field of the permanent magnet 11.To eliminate or at least reduce the effect of disturbing external magnetic fields the sensor chip 20 may be magnetically shielded by placing the sensor in the interior a hollow shaft, which is made of a ferromagnetic material and therefore acts as a shield against external magnetic fields.", "In the exemplary embodiment of FIG.", "2, the hollow shaft has the shape similar to a tube or a cylindrical sleeve.", "That is, the hollow shaft 10′ has a cylindrical hole that extends along the rotation axis and forms a cavity in the interior of the hollow shaft 10′.", "However, the hole does not necessarily extend through the whole shaft.", "To provide a sufficient shielding the ferromagnetic material may have a relative magnetic permeability of, e.g., 500 or higher.", "To avoid confusion between rotation shaft 10 and hollow shaft 10′ the term sleeve is used in the further discussion to denote the hollow shaft.", "The sleeve 10′ may be an integral part of the rotating shaft 10 (see FIG.", "1) or mechanically attached thereto.", "In the first case, the sleeve 10′ may be formed, e.g., by drilling a hole into the front of the shaft 10 along the rotation axis of the shaft 10.In the second case, the sleeve 10′ may be fixed to the shaft 10, for example using a press-fit or a screw thread.", "Furthermore, the sleeve 10′ may be glued to the shaft 10.The sleeve 10′ (as well as the hole in it) is axially symmetric with regard to the rotation axis (z-axis).", "Permanent magnet 11, as well as sensor chip 20, are placed on the rotation axis to form an axially symmetric set-up.", "Otherwise, the sleeve 10′ would asymmetrically distort the magnetic field of the permanent magnet 11.As mentioned above, magnet 11 may be attached to shaft 10 so that both can perform a common angular motion.", "Due to the absence of any relative motion between magnet 11 and shaft 10 eddy currents (and magnetic field components resulting therefrom) are avoided in the shaft.", "However, in some applications it may be useful to attach the sleeve 10′ to the stator and accept the negative effect of eddy currents.", "As in the general example of FIG.", "1, the magnetic field sensor shown in FIG.", "2 is attached to a stator that does not perform an angular motion with regard to the rotation axis.", "The sleeve 10′ is long enough (in an axial (z-) direction) that the permanent magnet 11 and the sensor chip 20 are fully accommodated in the interior of the sleeve (i.e.", "in the hollow space formed by the bore of the sleeve).", "Generally, the strength of the magnetic field H caused by a diametrically magnetized (e.g.", "in y-direction) permanent magnet of cylindrical shape and without a centric bore depends on its size.", "If the width (in x- or y-direction) of the magnet 11 is as large as the inner diameter of the sleeve 10′, the sleeve 10′ would form a magnetic short-circuit for the magnetic field H of permanent magnet 11 so that the resulting field strengths at the position of the sensor chip 20 would be almost zero.", "If the width of the permanent magnet 11 is small as compared to the inner diameter of the sleeve 10′, the resulting field strengths at the position of the sensor chip 20 is also small.", "Furthermore, a small magnet would generate a rather inhomogeneous magnetic field, which would result in measurement errors.", "Accordingly, a medium width (e.g.", "between 30 and 70 percent of the inner diameter of the sleeve 10′) of the permanent magnet 11 should be chosen as an optimum size.", "In a practical example, the width of the permanent magnet has been chosen to be 5 mm for a sleeve with an inner diameter of 12 mm.", "However, the larger the size of the permanent magnet 11, the better the homogeneity of the magnetic field on the sensor elements and this reduces angle errors caused by imprecise placement of the magnet 11 and the sensor chip 20 due to unavoidable production tolerances.", "When using permanent magnets with a very strong remanent magnetization (e.g.", "neodymium magnets with a remanent magnetization of 1 tesla), the width of the magnet 11 can be chosen between 70 and 90 percent of the inner diameter of the sleeve 10′ (e.g.", "a width of 10 mm for an inner diameter of 12 mm) to reduce the influence of production tolerances while still having large enough fields on the sensor elements.", "FIG.", "3 illustrates one exemplary embodiment of a rotary encoder which is composed of a magnetic set-up (e.g.", "the permanent magnet 11 and sleeve 10′ in the example of FIG.", "3) and a magnetic field sensor (sensor chip 20), which is placed in the magnetic center of the permanent magnet.", "The magnetic set-up is mechanically coupled to the rotating shaft whose angular position or velocity is to be measured.", "In most practical implementations the magnetic center will be identical to the geometric center of permanent magnet 11.When the permanent magnet is made of a homogeneous material, the geometric center is also identical with the center of mass of the permanent magnet (sometimes referred to as barycenter).", "In the following the term centroid is used, wherein in most practical cases there is no relevant difference between magnetic center, geometric center of the permanent magnet(s) and its (their) center of mass.", "As a consequence, sensor chip 20 is placed in the origin of a Cartesian coordinate system, in which one axis (in the present example of FIG.", "3 the z-axis) is in the rotation axis of the magnetic set-up and the two other axes (e.g.", "x-axis and y-axis) define a symmetry plane R of permanent magnet 11.In this coordinate system the centroid has the coordinates (0, 0, 0).", "In order to provide access to the centroid O of the magnetic set-up, the permanent magnet 11 includes a through-hole extending along the rotation axis to form a hollow space, in which the sensor chip 20 can be accommodated.", "In other words, the permanent magnet fully extends around the rotation axis (surrounding the hollow space).", "In the present example, permanent magnet 11 has the geometric form of a hollow cylinder (similar sleeve 10′).", "However, other geometries, which have a through-hole along the rotation axis, are applicable.", "The magnetization M of permanent magnet is (as in the previous examples) in a lateral (i.e.", "diametrical) direction, e.g.", "in the direction defined by the y-axis.", "The orientation of the magnetization of the permanent magnet 11 rotates with the shaft 10 (not shown in FIG.", "3).", "The sensor chip 20 is placed at the rotation axis in the middle of the (cylindrical) permanent magnet 11 as shown in FIG.", "3.However, due to the high magnetic permeability of sleeve 10′ it is not imperative to ensure that sleeve 10′ (which also acts as a flux guide (back iron) for permanent magnet 11) is also symmetrically arranged with respect to symmetry plane R. This is true as long as the symmetry of the magnetic field lines of permanent magnet 11 is not significantly deteriorated by an asymmetric placement of sleeve 10′.", "Investigations have shown that even comparable weak permanent magnets made of, for example, hard ferrite with a remanent magnetization of 0.22 tesla may generate a sufficiently high magnetic flux of, e.g., 40 millitesla at the centroid O.", "Generally, the magnetic center, in which sensor chip 20 is placed, is a point with a high symmetry with regard to the magnetic field and thus, the sensitivity of the rotary encoder with regard to unavoidable production tolerances is low.", "FIG.", "4 illustrates another embodiment of an rotary encoder.", "FIG.", "4 is essentially identical with FIG.", "3 except that shaft 10 and sleeve 10′ are one integral component, and the sleeve or the shaft has no through-hole.", "Accordingly, the sleeve 10′ is formed by forming a cavity 15 in the shaft 10, for example, by boring a hole (stud-hole) along the rotation axis into a front face of shaft 10.Alternatively, the whole shaft 10 may be hollow (e.g.", "a through-hole is formed in shaft 10 along its rotation axis); in this case the sleeve 10′ is formed by an end section of shaft 10.The permanent magnet 11, which also has the shape of a hollow cylinder, may be fitted in the sleeve 10′, for example, by gluing, by using a press-fit or other joining techniques.", "In one practical implementation the inner diameter D of sleeve 10′ (i.e.", "the inner diameter of cavity 15 formed in shaft 10 in the example if FIG.", "4) is 12 mm.", "The outer diameter of permanent magnet 11 is therefore also approximately 12 mm, whereas its axial length L1 is 10 mm and its inner diameter D1 is also 10 mm.", "Choosing a magnetic material with a remanent magnetization of 350 mT results in a magnetic flux of 40 mT at the centroid O of the set-up.", "Due to the high symmetry of the magnetic field in the centroid O, where sensor chip 20 is located, the measurement errors are comparably low for given productions and assembly tolerances.", "Additionally, a non-magnetic spacer may be inserted into the stud-hole (cavity 15), before inserting the permanent magnet.", "Such a spacer can be used to assure the correct and intended axial position of the permanent magnet.", "Such a spacer may have an outer diameter close to the diameter of the stud-hole with some channels on its outer surface along axial direction.", "This can be used to facilitate the application of a glue to fix the spacer and/or the magnet to the sleeve: if a well-defined amount of glue is applied to the end of the stud-hole and the spacer is inserted next, the spacer squeezes the glue up through its channels to reach its top surface, where it reaches the bottom surface of the ring-shaped permanent magnet, thereby fixing both, permanent magnet and spacer inside the stud-hole.", "For shafts 10 with a comparably small diameter, the inner diameter D1 the permanent magnet may be too small to accommodate a sensor chip.", "In such cases sleeve 10′ and shaft 10 may be separate components (see FIGS.", "5 to 8), wherein the sleeve 10′ is slipped over shaft 10 and mechanically coupled, e.g.", "using a press-fit or other suitable joining techniques.", "In the example illustrated in FIG.", "5, permanent magnet 11 has the shape of a hollow cylinder and is inserted in sleeve 10′ as in the previous example of FIG.", "4.The inner diameter D of sleeve 10′ and the outer diameter of permanent magnet 11 are approximately equal to form either a press fit, a medium fit or a loose fit dependent on which joining technique is used.", "In the example of FIG.", "5, sleeve 10′ is slipped over shaft 10 such that a front side of permanent magnet 11 adjoins a corresponding front side of shaft 10.The embodiment illustrated in FIG.", "5 is particularly suitable for applications, in which shaft 10 is made of a non-magnetic material or a material with a relatively low (close to 1) relative magnetic permeability.", "However, in applications, in which shaft 10 is made of a soft magnetic steel (such as structural steel) the magnetic field of permanent magnet 11 will be distorted due to the close proximity between permanent magnet 11 and shaft 10.As a consequence of such distortion the magnetic center is no more coincident with the geometric center of permanent magnet 11 and the position of the sensor chip 20.To further optimize the rotary encoder set-up for magnetic shafts, the embodiment of FIG.", "5 is slightly modified (see FIG.", "6).", "Accordingly, a cavity 15 is formed in the front side of shaft 10 so that cavity 15 adjoins permanent magnet 11 instead of the solid shaft as in the previous example.", "Cavity 15 may be formed by boring a hole into the front side of shaft 10 along the rotation axis, so that only a small portion of steel (i.e.", "the wall of cavity 15) remains along the circumference of shaft 10.In the present example the diameter D1 of cavity 15 is larger than the inner diameter D2 of permanent magnet 11, which results in a comparably thin walled end of the shaft, which may be difficult to produce.", "To simplify production the cavity formed in the shaft may have an inner diameter that is equal to or smaller than the inner diameter of the permanent magnet.", "However, the smaller the diameter of the cavity, the smaller is the beneficial effect of the cavity on the magnetic field at the centroid of the permanent magnet (i.e.", "at the position of sensor chip 20).", "A large diameter cavity will results in a point (in the geometric centroid of the permanent magnet) of good magnetic symmetry on the rotation axis.", "The axial size L of the cavity 15 should be preferably at least as large as half of the diameter D1 of the cavity.", "Again here the rule applies that a small axial extension of the cavity gives a correspondingly small beneficial effect of the cavity on the symmetry of the magnetic field at the centroid of the permanent magnet.", "However, for an axial extension larger than two times the diameter D1 a further increase of axial extension does not lead to significant improvements of symmetry in the magnetic field.", "Furthermore, the cavity may also have conical form, preferably with an aperture angle of less or equal 120°.", "Apart from cavity 15 the embodiment of FIG.", "6 is identical to the previous embodiment of FIG.", "5.Dependent on the actual application, further improvements may be achieved by modifying the embodiment of FIG.", "6 as shown in FIG.", "7.The example of FIG.", "7 is essentially the same as the previous example of FIG.", "6.However, the axial length L of cavity 15 is larger than the outer diameter D of permanent magnet 11.Furthermore, the outer end of sleeve 10′ (i.e.", "the end of sleeve 10′ not adjoining shaft 10) has an inward-bent collar 16, which may be produced, for example using a crimping tool.", "As a result, one front side of permanent magnet 11 is close to (or directly adjoins) a back side of collar 16 of the soft magnetic sleeve 10′, which acts as a flux guide (back iron) similar to shaft 10.Similarly, shaft 10 adjoins the opposing front side of permanent magnet 11.To ensure a high symmetry of the set-up the inner diameter of cavity 15 may be equal to the inner diameter of the inward-bent collar 16.The example of FIG.", "8 illustrates a minor modification of the previous example of FIG.", "7.Different from FIG.", "7, however, permanent magnet 11 is replaced by an assembly of two permanent magnets 11a and 11b, which are spaced apart by a spacer 12.Both permanent magnets 11a and 11b have the same shape as the permanent magnets 11 in the previous examples, i.e.", "the shape of a hollow cylinder.", "To ensure a symmetric set-up, permanent magnets 11a and 11b are identical in size, and sensor chip 20 is placed in the centroid, which is on the rotation axis between permanent magnet 11a and permanent magnet 11b.", "In this example, the magnetic center is the same as the geometric center of the permanent magnet arrangement, which includes permanent magnets 11a and 11b.", "Spacer 12 may be made of plastic (or any other non-magnetic material and having low permeability as compared to sleeve 10′) and may also have the shape of a hollow cylinder with the same outer diameter as permanent magnets 11a and 11b.", "To allow an easy assembly, a front side of permanent magnet 11a may be glued to a corresponding front side of spacer 12 while permanent magnet 11b is glued to the opposing front side of spacer 12 in the same manner.", "In case of a permanent magnet assembly including two (or more) permanent magnets it is important that the permanent magnets have a well-defined angular position relative to each other.", "In many applications it may be desired, for example, to align two permanent magnets such that the remanent magnetization of each permanent magnet points in the same direction (e.g.", "y-direction).", "That is, the magnets are aligned parallel to each other with regard to their magnetization, which means that north poles of one permanent magnet face north poles of the other permanent magnet and, therefore, the two magnets repell each other.", "However, in other applications it may be desirable to align the two permanent magnets such that the remanent magnetizations the two permanent magnets are oriented anti-parallel, which results in an attractive force between them.", "For this reason, it may be difficult to mechanically attach (e.g.", "by gluing) the permanent magnets to each other, and it may be important to provide some mechanical lock between both magnets that withstands the repelling or attracting forces between both permanent magnets at least during a certain time (e.g.", "while an adhesive cures).", "If the magnetization of both magnets is parallel, it is also possible to attach one to the other with a spacer in-between and magnetize them at the same time after they have been fixed to each other.", "This reduces the number of individual parts, facilitates handling, and improves the matching between the two permanent magnets, because they are magnetized simultaneously so that their magnetizations are well-aligned and of equal strength.", "Replacing the permanent magnet by an assembly of two permanent magnets may reduce the sensitivity of the rotary encoder with regard to tolerances in the axial placement of the permanent magnet.", "However, when assembling the two permanent magnets 11a and 11b, care should be taken to avoid an angular misalignment of the two permanent magnets 11a and 11b.", "A proper alignment of the two permanent magnets 11a and 11b is provided by the embodiment illustrated in FIG.", "9.The left part of FIG.", "9 is an exploded view of one example of a rotary encoder built in accordance with FIG.", "8.The right part of FIG.", "9 is a perspective cross-sectional view of the assembled rotary encoder.", "The present example is essentially the same as the previous example of FIG.", "8.In the present example, however, spacer 12 has the form of a ring (a hollow cylinder, which has a height smaller than its inner diameter), e.g.", "made of plastic.", "However, the spacer is composed of two half-rings.", "That is, the ring is split in two pieces along its symmetry axis.", "One half-ring is attached to permanent magnet 11a, and the second half-ring is attached to permanent magnet 11b, e.g.", "by gluing or injection molding of the half-ring directly onto the permanent magnets.", "When assembling the rotary encoder, the relative angular position of permanent magnets 11a and 11b is determined by the two half rings, which complement one another to form one ring-shaped spacer.", "The remaining components shown in FIG.", "9 are identical to the previous example of FIG.", "8.Although the disclosure has been illustrated and described with respect to one or more implementations, alterations and/or modifications may be made to the illustrated examples without departing from the spirit and scope of the appended claims.", "In particular regard to the various functions performed by the above described components or structures (units, assemblies, devices, circuits, systems, etc.", "), the terms (including a reference to a “means”) used to describe such components are intended to correspond—unless otherwise indicated—to any component or structure, which performs the specified function of the described component (e.g., that is functionally equivalent), even though not structurally equivalent to the disclosed structure, which performs the function in the herein illustrated exemplary implementations of the disclosure.", "For example, the permanent magnet(s) used in the embodiments described above have the shape of a hollow cylinder.", "However, any other hollow axially symmetric (rotation-symmetric) shape may be applicable instead of the mentioned hollow cylinder.", "For example, in a further embodiment a permanent magnet assembly may include two spherical half-shells of permanent magnetic material arranged symmetrically to the rotation axis and having a through-hole along the rotation axis.", "The two half-shells may be arranged spaced apart from each other by a ring-shaped spacer, e.g.", "as shown in FIGS.", "8 and 9.Further exemplary geometries for the permanent magnet(s) are (truncated) cone and double cone, ellipsoidal half-shells, etc., each having a hole along the rotation axis.", "Moreover, more than two permanent magnets may be used in one permanent magnet assembly.", "Furthermore, in the examples described above, the permanent magnet(s) is (are) magnetized in a lateral direction (i.e.", "in a direction perpendicular to the rotation axis, e.g.", "the y-axis).", "However, other geometries may be applicable.", "Instead of a homogeneous magnetization along the y-axis, the permanent magnet may be magnetized to form an axial quadrupole.", "In this case, one half of the permanent magnet (e.g.", "left of the plane defined by y=0) is magnetized parallel to the z-axis (rotation axis), and the other half (e.g.", "right of the plane defined by y=0) is magnetized anti-parallel to the z-axis.", "In addition, while a particular feature of the disclosure may have been disclosed with respect to only one of several implementations, such feature may be combined with one or more other features of the other implementations as may be desired and advantageous for any given or particular application.", "Furthermore, to the extent that the terms “including”, “includes”, “having”, “has”, “with”, or variants thereof are used in either the detailed description and the claims, such terms are intended to be inclusive in a manner similar to the term “comprising”." ] ]
Patent_15874275
[ [ "ANODE MATERIAL HAVING POROUS CORE-SHELL STRUCTURE AND METHOD OF PREPARING THE SAME AND BATTERY", "The present disclosure relates to an anode material having porous core-shell structure, the anode material includes a core formed of at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon, and a carbon shell coated on a surface of the core.", "The carbon shell contains amorphous carbon, cobalt element and tin element, and has a porous structure having a porosity greater than 10%.", "The present disclosure further relates to a method of preparing the anode material having porous core-shell structure, and a battery of which a negative electrode contains the anode material having porous core-shell structure." ], [ "1.An anode material having porous core-shell structure, comprising: a core formed of at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon; and a carbon shell coated on a surface of the core, wherein the carbon shell contains amorphous carbon, cobalt element and tin element, and has a porous structure having a porosity greater than 10%.", "2.The anode material of claim 1, wherein the porous structure has a porosity greater than 10% and less than 30%, and a pore diameter of the porous structure is about 50 nanometers to about 150 nanometers.", "3.The anode material of claim 1, wherein a weight ratio of carbon element of the carbon shell to the core is about 1-2:10.4.The anode material of claim 1, wherein a weight ratio of cobalt element, tin element to carbon element of the carbon shell is about 1:2-4:4-8, the cobalt element and the tin element are presented in the carbon shell in a form of tin cobalt alloy particle, and the tin cobalt alloy particle has a particle diameter of about 30 nanometers to about 70 nanometers.", "5.The anode material of claim 1, wherein the core contains a graphite having a particle diameter of about 8 microns to about 18 microns.", "6.The anode material of claim 1, wherein the carbon shell further contains calcium element and at least one selected from a group consisting of carbon nano tube, acetylene black and graphene, wherein the calcium element has a content less than 0.01 wt %.", "7.A method of preparing an anode material having porous core-shell structure, comprising: dispersing, at least one selected from a group consisting of calcium carbonate and calcium oxalate, and at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon, into a first solution to obtain a dispersion solution, wherein the first solution contains cobalt compound and tin compound; introducing a precipitant into the dispersion solution to carry out precipitation; obtaining a first solid phase by solid-liquid separation of the precipitated dispersion solution; dispersing the first solid phase into a second solution containing carbon source material; obtaining a second solid phase by removing solvent; and treating the second solid phase with a high temperature decomposition treatment in inert atmosphere.", "8.The method of claim 7, wherein after the high temperature decomposition treatment, the carbon source material is decomposed into elemental carbon to form a carbon shell on a surface of a core formed of the carbonaceous material, wherein a ratio of the carbon source material and the carbonaceous material is determined by a weight ratio of carbon element of the carbon shell to the core, and the weight ratio of carbon element of the carbon shell to the core is about 1-2:10.9.The method of claim 7, wherein the carbon source material is at least one selected from a group consisting of petroleum asphalt, coal pitch, saccharose, glucose, starch, phenolic resin and epoxy resin.", "10.The method of claim 7, wherein a ratio of the cobalt compound and the tin compound is determined by a weight ratio of cobalt element, tin element to carbon element in the carbon shell, and the weight ratio of cobalt element, tin element to carbon element in the carbon shell is about 1:2-4:4-8.11.The method of claim 7, wherein the cobalt compound is at least one selected from a group consisting of cobalt dichloride, cobalt nitrate, cobaltous sulfate, cobaltous acetate and cobalt oxalate.", "12.The method of claim 7, wherein the tin compound is at least one selected from a group consisting of stannous mono-sulphate, stannous chloride, and C1-C4 alkyl sulfonate tin.", "13.The method of claim 7, wherein the at least one selected from a group consisting of calcium carbonate and calcium oxalate and the carbonaceous material are dispersed into the first solution with a dispersant, and the dispersant is at least one selected from a group consisting of polyvinylpyrrolidone, polyving akohol, polyethylene glycol, polyacrylamide and carboxymethylcellulose.", "14.The method of claim 7, wherein the precipitant is at least one selected from a group consisting of ammonium bicarbonate, aqua ammonia, carbamide, sodium bicarbonate and potassium bicarbonate.", "15.The method of claim 7, wherein the at least one selected from a group consisting of calcium carbonate and calcium oxalate and the carbonaceous material are dispersed into the first solution via ball-milling under a rotate speed of about 50 rpm to about 200 rpm for about 1 hour to about 5 hours.", "16.The method of claim 7, wherein the precipitation is carried out under a temperature of about 60 Celsius degrees to about 80 Celsius degrees for about 0.5 hours to about 3 hours.", "17.The method of claim 7, wherein the first solid phase is dispersed into the second solution under a temperature of about 80 Celsius degrees to about 100 Celsius degrees for about 0.5 hours to about 1 hour.", "18.The method of claim 7, wherein the high temperature decomposition treatment comprises: heating the second solid phase to about 300 Celsius degrees to about 500 Celsius degrees with a heating rate of about 2 Celsius degrees per minute to about 5 Celsius degrees per minute; dwelling for about 2 hours to about 4 hours; heating the second solid phase to about 950 Celsius degrees to about 1050 Celsius degrees with a heating rate of about 5 Celsius degrees per minute to about 10 Celsius degrees per minute; and dwelling for about 3 hours to about 6 hours.", "19.The method of claim 7, wherein dispersing the first solid phase into the second solution further comprises introducing an addition agent during the dispersing, and the addition agent is at least one selected from a group consisting of carbon nano tube, acetylene black and graphene.", "20.A battery, comprising a negative electrode containing an anode material having porous core-shell structure, wherein the anode material comprises: a core formed of at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon; and a carbon shell coated on a surface of the core, wherein the carbon shell contains amorphous carbon, cobalt element and tin element, and has a porous structure having a porosity greater than 10%." ], [ "<SOH> BACKGROUND <EOH>In related technology of preparing a complex of mesoporous carbon ball and Sn—Co, the Sn anode material coated with mesoporous carbon obtained has a low porosity, and a pore size is small, which cannot well ease the problem of volume expansion of the anode material during charging and discharging, and then the battery obtained could not achieve a good electrical cycle performance.", "The Sn anode material coated with mesoporous carbon may have many side effects and an initial charge-discharge efficiency may be relatively low." ], [ "<SOH> SUMMARY <EOH>The present disclosure seeks to provide an anode material having porous core-shell structure and method of preparing the same and a battery, such that volume expansion of anode material during charging and discharging may be well prevented so as to obtain a relatively better electrical cycle performance.", "Thus, embodiments of a first aspect of the present disclosure provide an anode material having porous core-shell structure, the anode material includes: a core formed of at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon, and a carbon shell coated on a surface of the core, the carbon shell contains amorphous carbon, cobalt element and tin element, and has a porous structure having a porosity greater than 10%.", "Embodiments of a second aspect of the present disclosure further provide a method of preparing an anode material having porous core-shell structure, which includes steps of: dispersing a calcium carbonate and/or a calcium oxalate and at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon into a first solution containing cobalt compound and tin compound to obtain a dispersion solution, and introducing precipitant into the dispersion solution to carry out precipitating, and obtaining a first solid phase after solid-liquid separation; dispersing the first solid phase into a second solution containing carbon source material, and obtaining a second solid phase after removing solvent; and subjecting the second solid phase to a high temperature decomposition treatment in inert atmosphere.", "Embodiments of a third aspect of the present disclosure further provide an anode material having porous core-shell structure prepared via the method mentioned above.", "Embodiments of a fourth aspect of the present disclosure further provide a battery, of which a negative electrode contains the anode material having porous core-shell structure mentioned above.", "Advantageous effects of the technology solution of the present disclosure may be: the anode material having porous core-shell structure may prevent the volume expansion during charging and discharging, and then a negative electrode made of the anode material having porous core-shell structure of the present disclosure may improve an electrical cycle performance of the battery obtained.", "These and other aspects and advantages of embodiments of the present disclosure will be described in detail with reference to the following detailed description." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation application of International Application No.", "PCT/CN2016/098421, filed on Sep. 8, 2016, which is based on and claims priority to and benefits of Chinese Patent Application No.", "201510641136.5, filed with the State Intellectual Property Office (SIPO) of the People's Republic of China on Sep. 30, 2015.The entire contents of the above-identified application is incorporated herein by reference.", "FIELD Embodiments of the present disclosure generally relate to an anode material having porous core-shell structure and method of preparing the same and battery.", "BACKGROUND In related technology of preparing a complex of mesoporous carbon ball and Sn—Co, the Sn anode material coated with mesoporous carbon obtained has a low porosity, and a pore size is small, which cannot well ease the problem of volume expansion of the anode material during charging and discharging, and then the battery obtained could not achieve a good electrical cycle performance.", "The Sn anode material coated with mesoporous carbon may have many side effects and an initial charge-discharge efficiency may be relatively low.", "SUMMARY The present disclosure seeks to provide an anode material having porous core-shell structure and method of preparing the same and a battery, such that volume expansion of anode material during charging and discharging may be well prevented so as to obtain a relatively better electrical cycle performance.", "Thus, embodiments of a first aspect of the present disclosure provide an anode material having porous core-shell structure, the anode material includes: a core formed of at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon, and a carbon shell coated on a surface of the core, the carbon shell contains amorphous carbon, cobalt element and tin element, and has a porous structure having a porosity greater than 10%.", "Embodiments of a second aspect of the present disclosure further provide a method of preparing an anode material having porous core-shell structure, which includes steps of: dispersing a calcium carbonate and/or a calcium oxalate and at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon into a first solution containing cobalt compound and tin compound to obtain a dispersion solution, and introducing precipitant into the dispersion solution to carry out precipitating, and obtaining a first solid phase after solid-liquid separation; dispersing the first solid phase into a second solution containing carbon source material, and obtaining a second solid phase after removing solvent; and subjecting the second solid phase to a high temperature decomposition treatment in inert atmosphere.", "Embodiments of a third aspect of the present disclosure further provide an anode material having porous core-shell structure prepared via the method mentioned above.", "Embodiments of a fourth aspect of the present disclosure further provide a battery, of which a negative electrode contains the anode material having porous core-shell structure mentioned above.", "Advantageous effects of the technology solution of the present disclosure may be: the anode material having porous core-shell structure may prevent the volume expansion during charging and discharging, and then a negative electrode made of the anode material having porous core-shell structure of the present disclosure may improve an electrical cycle performance of the battery obtained.", "These and other aspects and advantages of embodiments of the present disclosure will be described in detail with reference to the following detailed description.", "BRIEF DESCRIPTION OF THE DRAWINGS The drawings are used for further comprehending the present disclosure, it should constitute as one part of the description, and be used to explain the present disclosure together with the detailed description, however it should not be constructed as limit to the present disclosure.", "FIG.", "1 is a field emission scanning electron micrograph of an anode material obtained in Embodiment 1 of the present disclosure; and FIG.", "2 is a partial enlarged view of a field emission scanning electron micrograph of the anode material obtained in Embodiment 1 of the present disclosure.", "DETAILED DESCRIPTION Reference will be made in detail to embodiments of the present disclosure.", "The embodiments described herein are explanatory and illustrative, which are used to generally understand the present disclosure.", "The embodiments shall not be construed to limit the present disclosure.", "According to a first aspect of embodiments of the present disclosure, the present disclosure provides an anode material having porous core-shell structure, the anode material includes a core formed of at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon, and a carbon shell coated on a surface of the core.", "The carbon shell contains amorphous carbon, cobalt element and tin element, and has a porous structure having a porosity greater than 10%.", "In some embodiments of the present disclosure, the anode material includes a core and a carbon shell.", "The core is formed from at least one carbonaceous material (for example, graphite), while the carbon shell is formed from amorphous carbon.", "The amorphous carbon may be usually obtained via high temperature carbonization of some carbon source material (see below for detailed description).", "The carbon shell has a porous structure, which may reserve enough space for volume expansion and shrinkage of the anode material during intercalation/de-intercalation of lithium so as to avoid constantly bursting and generating of a SEI film (solid electrolyte interface film) caused by volume varies of the anode material during charging and discharging, such that a recycle performance of a battery may be improved.", "In some embodiments of the present disclosure, the carbon shell has a porosity greater than 10%, for example the carbon shell has a porosity of about 10% to about 30%.", "The porosity means a percentage of a pore volume in a total volume of the carbon shell.", "In some embodiments of the present disclosure, a pore diameter of the porous structure is about 50 nanometers to about 150 nanometers.", "Therefore, the anode material of these embodiments may provide a carbon shell with higher porosity and greater pore diameter, which may be compatible with a charge and discharge performance of graphite of the core better, and then the anode material may have higher specific capacity (both a volumetric specific capacity and a mass specific capacity are improved).", "In some embodiments of the present disclosure, the cobalt element and tin element are dispersed into the carbon shell.", "The tin element may be interpreted as an active metal component of the anode material, which could improve a theoretical specific capacity of the battery, while the existence of cobalt element may ease the effect of volume expansion well.", "Under the condition that the carbon shell has a porous structure, the battery obtained may not only have a relatively high capacity, but also the effect of easing volume expansion of negative electrode of the battery may be better, and then the battery obtained may have a better recycle performance.", "In some embodiments of the present disclosure, a weight ratio of cobalt element, tin element to carbon element of the carbon shell is about 1:2-4:4-8.In some embodiments of the present disclosure, the cobalt element and the tin element are presented in the carbon shell in a form of tin cobalt alloy particle, and the tin cobalt alloy particle has a particle diameter of about 30 nanometers to about 70 nanometers.", "In some embodiments of the present disclosure, the tin cobalt alloy particle is at least one selected from a group consisting of CoSn, CoSn2, and Co3Sn2.However, the present disclosure does not exclude other situation, for example, the cobalt element and the tin element are presented in the carbon shell in a form of cobalt oxide particle and tin oxide particle respectively.", "In some other embodiments, the cobalt oxide particle is a nano cobalt oxide particle having a particle diameter of about 20 nanometers to about 50 nanometers (for example, about 20 nanometers to about 40 nanometers), and the tin oxide particle is a nano tin oxide particle having a particle diameter of about 30 nanometers to about 80 nanometers (for example, about 30 nanometers to about 60 nanometers).", "In some embodiments of the present disclosure, the porous structure of the carbon shell is formed in a manner of restoration pore.", "Specifically, a calcium oxide and a carbon dioxide are obtained through decomposing on a pore structure foundation.", "The pore structure foundation is formed via decomposed carbide of a carbon source material which forms the carbon shell.", "As more and larger pores may be formed due to an escape of the carbon dioxide, and larger through pores may be formed especially after washing out the calcium oxide obtained from decomposing a calcium carbonate and/or a calcium oxalate, the porous structure can be formed in the carbon shell.", "It should be noted that the present disclosure does not exclude a situation that a portion of calcium element (including in at least one form of calcium carbonate, calcium oxalate and calcium oxide) may be reserved in the carbon shell.", "In some embodiments of the present disclosure, the carbon shell contains calcium element less than 0.01 wt % (based on a total weight of the carbon shell).", "In some embodiments of the present disclosure, the carbon shell further includes an addition agent, for example, the carbon shell further includes at least one selected from a group consisting of carbon nano tube, acetylene black and graphene, which may improve stability and conductivity of the shell.", "In some embodiments of the present disclosure, the addition agent has a content less than 30 wt % (based on a total weight of the carbon shell).", "In some embodiments of the present disclosure, a weight ratio of carbon element of the carbon shell to the core is about 1-2:10, and the anode material obtained may have better recycle performance.", "In some embodiments of the present disclosure, the core includes a graphite having a particle diameter of about 8 microns to about 18 microns (for example, a spheroidal-graphite having a particle diameter of about 8 microns to about 18 microns).", "In some embodiments of the present disclosure, under the condition that satisfies the weight ratio of the carbon element of the carbon shell to the core, a thickness of the carbon shell could be about 0.2 microns to about 2 microns, such that the anode material obtained may have a size distribution D50 of about 8 microns to about 20 microns.", "According to embodiments of the present disclosure, the anode material having porous structure may have relatively better electrical performance.", "Specifically, through button battery test method, under 25 Celsius degrees, a weight ratio intercalation capacity is about 420 mAh/g to about 440 mAh/g, and a weight ratio de-intercalation capacity is about 365 mAh/g to about 380 mAh/g.", "After 50 times of recycle, a retention rate of weight ratio capacity may be greater than 79% (for example, greater than 84%).", "According to a second aspect of embodiments of the present disclosure, the present disclosure provides a method of preparing an anode material having porous core-shell structure, the method comprising steps of: dispersing a calcium carbonate and/or a calcium oxalate and at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon into a first solution containing cobalt compound and tin compound to obtain a dispersion solution, and introducing precipitant into the dispersion solution to carry out precipitating, and obtaining a first solid phase after solid-liquid separation; dispersing the first solid phase into a second solution containing carbon source material, and obtaining a second solid phase after removing solvent; and treating the second solid phase with a high temperature decomposition treatment in inert atmosphere.", "In some embodiments of the present disclosure, the calcium carbonate and/or the calcium oxalate and at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon are dispersed into the first solution containing cobalt compound and tin compound so as to obtain a dispersion solution, and then the precipitant is utilized such that cobalt element and tin element could adhere to the carbonaceous material in a manner of generating a precipitate, therefore the precipitate containing cobalt element and tin element and the calcium carbonate and/or the calcium oxalate are adhered to a surface of the carbonaceous material, namely the first solid phase obtained.", "In some embodiments of the present disclosure, a size of the calcium carbonate and/or the calcium oxalate and the carbonaceous material could vary in a relatively wide range, the size of the calcium carbonate and/or the calcium oxalate determines, to a great extent, the pore diameter of the carbon shell of the anode material obtained, and the size of the carbonaceous material determines, to a great extent, the size of the anode material obtained.", "In some embodiments of the present disclosure, the calcium carbonate is a nano-calcium carbonate particle having a particle diameter of about 40 nanometers to about 80 nanometers.", "In some embodiments of the present disclosure, the calcium oxalate is a nano-calcium oxalate particle having a particle diameter of about 40 nanometers to about 80 nanometers.", "In some embodiments of the present disclosure, the carbonaceous material includes a graphite, for example, a spherical graphite particle having a particle diameter of about 8 microns to about 18 microns.", "In some embodiments of the present disclosure, the cobalt compound is at least one selected from a group consisting of cobalt dichloride, cobalt nitrate, cobaltous sulfate, cobaltous acetate and cobalt oxalate, while the tin compound is at least one selected from a group consisting of stannous mono-sulphate, stannous chloride, and C1-C4 alkyl sulfonate tin (for example, stannous methanesulfonate, tin ethyl sulfonate).", "In some embodiments of the present disclosure, a ratio of the cobalt compound and the tin compound are determined such that a weight ratio of cobalt element, tin element to carbon element in the carbon shell is about 1:2-4:4-8.In some embodiments of the present disclosure, based on 100 weight parts of the carbonaceous material, a concentration of the cobalt compound calculated via the cobalt element is about 1 weight part to about 10 weight parts (for example, about 3 weight parts to about 6 weight parts), a concentration of the tin compound based calculated via the tin element is about 8 weight parts to about 30 weight parts (for example, about 12 weight parts to about 18 weight parts), and a concentration of the carbon source material is about 10 weight parts to about 40 weight parts (for example, 15 weight parts to about 30 weight parts).", "In some embodiments of the present disclosure, in the first solution containing cobalt compound and tin compound, the cobalt compound has a concentration of about 1 wt % to about 20 wt % (for example, about 1.5 wt % to about 3 wt %), while the tin compound has a concentration of about 3 wt % to about 36 wt % (for example, about 4 wt % to about 6 wt %).", "In order to disperse the calcium carbonate and/or the calcium oxalate and the carbonaceous material in the first solution containing cobalt compound and tin compound well, in some embodiments of the present disclosure, the calcium carbonate and/or the calcium oxalate and the carbonaceous material are dispersed into the first solution containing cobalt compound and tin compound under the existence of a dispersant, the dispersant is at least one selected from a group consisting of polyvinylpyrrolidone, polyving akohol, polyethylene glycol, polyacrylamide and carboxymethylcellulose.", "In some embodiments of the present disclosure, based on 100 weight parts of the carbonaceous material, a concentration of the dispersant is about 10 weight parts to about 20 weight parts.", "In some embodiments of the present disclosure, for example, the dispersion solution could be prepared by dispersing the calcium carbonate and/or the calcium oxalate and the carbonaceous material in the first solution containing cobalt compound and tin compound via stirring or ball-milling.", "In some embodiments of the present disclosure, the calcium carbonate and/or the calcium oxalate and the carbonaceous material are dispersed into the first solution containing cobalt compound and tin compound via ball-milling under a rotate speed of about 50 rpm to about 200 rpm (for example, about 50 rpm to about 100 rpm) for about 1 hour to about 5 hours (for example, about 1 hour to about 2 hours) to obtained the dispersion solution.", "In some embodiments of the present disclosure, the ball-milling is performed with a zirconium ball greater than 10 millimeters, such that the carbonaceous material may maintain its size.", "In some embodiments of the present disclosure, the precipitant is at least one selected from a group consisting of ammonium bicarbonate, aqua ammonia, carbamide, sodium bicarbonate and potassium bicarbonate, such that the cobalt element and tin element provided by the cobalt compound and the tin compound respectively could adhere to the surface of the carbonaceous material in a form of precipitate.", "In some embodiments of the present disclosure, the precipitant is added into the dispersion solution in a form of precipitant solution, for example, the precipitant solution may be at least one selected from a group consisting of an ammonium bicarbonate solution having a concentration of about 15 g/L to about 35 g/L, an aqua ammonia having a concentration of about 8 g/L to about 16 g/L, and a carbamide solution having a concentration of about 20 g/L to about 30 g/L.", "In order to sufficiently utilize the cobalt element and tin element provided by the cobalt compound and the tin compound respectively, in some embodiments of the present disclosure, the precipitation is carried out under a temperature of about 60 Celsius degrees to about 80 Celsius degrees for about 0.5 hours to about 3 hours.", "In some embodiments of the present disclosure, the precipitant solution is added in the dispersion solution via drop-adding method.", "When utilizing drop-adding method, the time of precipitating could be interpreted as a time including a time consumed during drop-adding, or the time of precipitating is the time consumed during drop-adding.", "Even though the cobalt element and tin element adhered to the surface of the carbonaceous material are basically in the form of precipitate of cobalt element (such as at least one of cobalt carbonate, cobalt carbonate and cobalt hydroxide) and precipitate of tin element (such as at least one of tin carbonate, alkaline tin carbonate and tin hydroxide), the present disclosure does not limit to this, it should be noted by those skilled in the art, the cobalt element and tin element adhered to the surface of the graphite particle could also be in the form of the cobalt compound and the tin compound.", "In some embodiments of the present disclosure, after solid-liquid separation, the first solid phase could be obtained, in order to better disperse the first solid phase into the second solution containing carbon source material, the first solid phase obtained after solid-liquid separation is firstly dried (for example, dried under a temperature of about 30 Celsius degrees to about 60 Celsius degrees for about 5 hours to about 10 hours).", "In some embodiments of the present disclosure, through dispersing the first solid phase into the second solution containing carbon source material, a carbonaceous material loaded with carbon source material may be obtained after removing solvent, then the carbon source material may be decomposed to generate elemental carbon after the high temperature decomposition treatment.", "The elemental carbon forms the carbon shell on the surface of the carbonaceous material which plays as the core.", "In some embodiments of the present disclosure, the carbon source material is at least one selected from petroleum asphalt, coal pitch, saccharose, glucose, starch, phenolic resin and epoxy resin.", "In some embodiments of the present disclosure, a ratio of the carbon source material and the carbonaceous material are determined such that a weight ratio of carbon element of the carbon shell to the core is about 1-2:10.Satisfying such weight ratio, a concentration described above of the carbon source material is adopted.", "In order to disperse the first solid phase and the carbon source material well, in some embodiments of the present disclosure, the carbon source material is presented in a form of solution.", "In some embodiments of the present disclosure, a solvent of the solution of the carbon source material is at least one selected from a group consisting of naphthaline, acetone, carbon tetrachloride, ethyl alcohol and water.", "In some embodiments of the present disclosure, a content of the carbon source material in the solution of the carbon source material is about 3 wt % to about 20 wt %.", "In some embodiments of the present disclosure, dispersing the first solid phase in the second solution containing carbon source material further includes introducing an addition agent during dispersing, such that the anode material obtained may have a better performance.", "In some embodiments of the present disclosure, the addition agent is at least one selected from a group consisting of carbon nano tube, acetylene black and graphene.", "In some embodiments of the present disclosure, for example, a concentration of the addition agent may be determined such that a content of the addition agent in the carbon shell of the obtained anode material is less than 30 wt %.", "In terms of satisfying such condition, for example, with respect to 100 weight parts of carbonaceous material, the concentration of the addition agent is less than 3 weight parts.", "In some embodiments of the present disclosure, the first solid phase is dispersed into the second solution containing carbon source material under a temperature of about 80 Celsius degrees to about 100 Celsius degrees for about 0.5 hours to about 1 hour.", "The dispersion could be performed under stirring.", "In some embodiments of the present disclosure, the method of removing the solvent includes: heating the second solution to about 210 Celsius degrees to about 230 Celsius degrees and dwelling for about 1 hour to about 3 hours, and then heating the second solution to about 250 Celsius degrees to about 280 Celsius degrees and dwelling for about 1 hour to about 3 hours.", "In some embodiments of the present disclosure, a substance having a core and a carbon shell made of carbon source material is obtained after dispersing the first solid phase into the second solution containing carbon source material, and the carbon source material includes cobalt element, tin element and calcium carbonate and/or calcium oxalate and at least one carbonaceous material selected from a group consisting of graphite, hard carbon and soft carbon.", "While the purpose of high temperature decomposition treatment is to decompose the carbon source material into amorphous carbon, and decompose the calcium carbonate and/or the calcium oxalate into calcium oxide and carbon dioxide.", "The carbon shell of the anode material may be obtained during the process of decomposing the carbon material into amorphous carbon, a co-precipitate of cobalt element and tin element may basically be reduced by carbon so as to obtain tin cobalt alloy, and the releasing of carbon dioxide, which is obtained from the decomposition of the calcium carbonate and/or the calcium oxalate, may form through pores to some extent.", "In some embodiments of the present disclosure, the high temperature decomposition treatment is performed under a temperature of about 850 Celsius degrees to about 1050 Celsius degrees for about 2 hours to about 6 hours.", "In some other embodiments of the present disclosure, the high temperature decomposition treatment is performed by heating the second solid phase to about 300 Celsius degrees to about 500 Celsius degrees with a heating rate of about 2 Celsius degrees per minute to about 5 Celsius degrees per minute and dwelling for about 2 hours to about 4 hours, and then heating the second solid phase to about 950 Celsius degrees to about 1050 Celsius degrees with a heating rate of about 5 Celsius degrees per minute to about 10 Celsius degrees per minute and dwelling for about 3 hours to about 6 hours.", "In some embodiments of the present disclosure, the inert atmosphere is at least one selected from a group consisting of nitrogen, argon and helium gas.", "In order to maintain the inert atmosphere well and make the high temperature decomposition treatment more efficiently, in some embodiments of the present disclosure, prior to the high temperature decomposition treatment, an inactive gas is introduced for about 2 to about 5 hours so as to make a content of oxygen is less than 50 ppm, and during the process of high temperature decomposition treatment, an inactive gas is continually introduced at a rate of 0.2-0.5 m3/h.", "In some embodiments of the present disclosure, in order to obtain an anode material with better performance, the method of the present disclosure further includes a step of washing a third solid phase obtained after the high temperature decomposition treatment.", "In some embodiments of the present disclosure, for example, the calcium oxide obtained from the decomposition of the calcium carbonate and/or the calcium oxalate may be washed out through the washing step, such that the position occupied by the calcium carbonate and/or the calcium oxalate forms a pore, therefore, the carbon shell obtained may have a more suitable porous structure.", "As illustrated above, the main purpose of the washing step is to remove the calcium oxide obtained from the decomposition of the calcium carbonate and/or the calcium oxalate.", "In some embodiments of the present disclosure, the third solid phase obtained after the high temperature decomposition treatment is introduced in water (for example, deionized water), a ratio of which is determined such that a solid-to-liquid ratio (mass ratio) is about 1:5-10 (in each time of washing), with stirring and washing for about 1 to 3 hours.", "The washing step may be repeated for about 3 to 4 times, and then the solid phase obtained is dried to obtain the abode material having porous structure of the present disclosure.", "It should be understood that, even though the purpose of the washing step is to remove the calcium oxide, the anode material of the present disclosure may be an anode material in which the calcium carbonate and/or calcium oxalate are totally decomposed and the calcium oxide is totally removed, or an anode material in which part of the calcium carbonate and/or calcium oxalate are not decomposed and part of the calcium oxide is retained.", "For example, a content of calcium, because of residual of the calcium carbonate and/or calcium oxalate and the calcium oxide, in the carbon shell may be less than 0.01 wt %.", "In some embodiments of the present disclosure, the anode material includes an node material in which the calcium carbonate and/or calcium oxalate are totally decomposed and the calcium oxide is totally removed.", "According to a third aspect of embodiments of the present disclosure, the present disclosure provides an anode material having porous core-shell structure, which is prepared via the method mentioned above.", "Description of the anode material having porous core-shell structure is described above, thus repeated description is omitted herein.", "According to a fourth aspect of embodiments of the present disclosure, the present disclosure provides a battery, the battery includes a negative electrode containing the anode material having porous core-shell structure mentioned above.", "A method of obtaining the negative electrode, for example, may include steps of: mixing the anode material having porous core-shell structure, a negative binder and a negative solvent, coating and/or filling on a negative collector to form a negative material layer on a surface of the negative collector, and drying, rolling or not rolling the negative material layer, to obtain the negative electrode.", "In some embodiments of the present disclosure, a content of the anode material having porous core-shell structure in the negative material layer is about 80 wt % to about 80 wt %.", "In some embodiments of the present disclosure, the negative binder may be at least one modified or non-modified binder selected from a group consisting of carboxymethylcellulose (CMC), polyvinylidene fluoride (PVDF), polytetrafluoroethylene (PTFE), polyving akohol (PVA), styrene butadiene rubber (SBR) and polyolefine emulsion.", "Generally, according to different kind of the negative binder, based on 100 weight parts of the anode material of the present disclosure, a concentration of the negative binder could be 0.01 to about 10 weight parts, for example about 0.02 to 8 weight parts.", "In some embodiments of the present disclosure, the negative material layer further includes a negative conductive agent, such that a conductivity of the anode material may be improved, the negative conductive agent could be at least one selected from a group consisting of carbon black, nickel powder and copper powder.", "In some embodiments of the present disclosure, an active material of positive electrode could be at least one selected from a group consisting of, such as, LiCoO2, LiVPO4, LiCoAlO2, LiMnCoO2, LiCoxNiyMnzO2 (x+y+z=1), LiMn2O4, LiNiO2 and LiFexM1-xPO4 (M could be Co, Ni, Mn, and 0.8≤x≤1).", "In some embodiments of the present disclosure, a positive conductive agent of a cathode material could be at least one selected from a group consisting of, such as, carbon black, graphite, acetylene black, carbon fiber, carbon nano tube, carbonyl nickel powder, copper powder, iron powder, zinc powder and aluminum powder.", "In some embodiments of the present disclosure, based on 100 weight parts of the active material of positive electrode, the positive conductive agent has a content of about 0.5 weight parts to about 15 weight parts, for example, about 1 to about 10 weight parts.", "In some embodiments of the present disclosure, a positive binder of the cathode material could be at least one selected from a group consisting of, such as, polyvinylidene fluoride, polytetrafluoroethylene, polyacrylate (containing fluorine), polyurethane (containing fluorine), epoxy resin(containing fluorine), butadiene styrene rubber, polymethylcellulose, polymethylcellulose sodium, hydroxy propyl methyl cellulose, polypropylene glycol, and butadiene styrene rubber (SBR).", "Generally, according to different kinds of the positive binder, based on 100 weight parts of the active material of positive electrode, a concentration of the positive binder in the cathode material could be about 0.01 weight parts to about 10 weight parts, for example, about 0.02 weight parts to about 7 weight parts.", "In some embodiments of the present disclosure, a positive solvent used during preparing the positive electrode could be at least one selected from a group consisting of, such as, N-methyl pyrrolidone, dimethylformamide, formyldiethylamine, dimethyl sulfoxide, tetrahydrofuran and water and alcoholic solvents.", "In some embodiments of the present disclosure, the current collector of the positive electrode and the negative electrode could be, such as, aluminum foil, copper foil or punching-hole steel belt.", "In some embodiments of the present disclosure, a separator with electrical insulation performance and liquid retention performance is disposed between the positive electrode and the negative electrode.", "The separator could be any separator that used for a lithium battery, such as polyolefine microporous membrane, polyethylene felt, glass fiber felt or ultra-fine glass fiber paper.", "In some embodiments of the present disclosure, a non-aqueous electrolyte of the battery includes a mixing solution of lithium electrolyte salt and non-aqueous solvent.", "The lithium electrolyte salt could be at least any one selected from a group consisting of lithium Hexafluorophosphate (LiPF6), lithium perchlorate, lithium tetrafluoroborate, lithium hexafluoroarsenate, lithium halide, aluminium chloride acid lithium and lithium fluorocarbon sulfonate.", "The non-aqueous solvent could be a mixing solution of chain acid ester and cyclic acid ester, the chain acid ester could be at least any one selected from a group consisting of dimethyl carbonate (DMC), diethyl carbonate (DEC), ethyl methyl carbonate (EMC), methyl propyl carbonate (MPC), dipropyl carbonate (DPC) and other chain organic esters which contain fluorine, sulphur or unsaturated bond.", "The cyclic acid ester could be at least any one selected from a group consisting of ethylene carbonate (EC), propylene carbonate (PC), vinylene carbonate (VC), γ-butyrolactone (γ-BL), sultone and other cyclic organic ester.", "In some embodiments of the present disclosure, an injected volume of the non-aqueous electrolyte is about 1.5 to about 5.5 g/Ah, and a concentration of the non-aqueous electrolyte is about 0.1 to about 2.0 mol/L.", "Since the battery above includes the anode material having porous core-shell structure of the present disclosure, expansion of anode material may be well prevented, such that the battery obtained may have better cycle performance.", "Detailed descriptions of the present disclosure will be given below by referring to Embodiment.", "A weight ratio of cobalt element, tin element to carbon element of the carbon shell is measured through ICP/AAS, TG-DSC.", "A porosity of the carbon shell is measured through BET, mercury intrusion method.", "A pore diameter of the carbon shell is measured through BET, SEM.", "A thickness of the carbon shell is measured through TG-DSC, TEM.", "Embodiment 1 This embodiment is used herein to illustrate the anode material of the present disclosure and its preparation method.", "(1) A polyvinylpyrrolidone (5 grams, K-30 purchased from Sinopharm Chemical Reagent Co., Ltd) is added into an aqueous solution of cobalt chloride and stannous mono-sulphate (300 grams, a content of cobalt chloride is 1.8 wt %, a content of stannous mono-sulphate is 4.8 wt %), after stirring solvent, 1 gram of nano calcium carbonate powder (of which particle diameter is 50 nanometers, purchased from Shenzhen Puli chemical Co., LTD, following are the same) and 50 grams of spherical graphite powder (of which particle diameter is 11 μm, NG_21 purchased from Qingdao Taihelong New Energy Materials Co., LTD) are added to form a mixture, and then the mixture is placed in a ball mill tank (a diameter of zirconium ball is 10 millimeters) to perform ball-milling under a speed of 50 rpm so as to obtain a dispersion solution.", "Then 500 mL aqueous solution of ammonium bicarbonate (a content of ammonium bicarbonate is 16.1 grams) is dropping added via a metering pump for 3 hours into the dispersion solution of which a temperature is maintained at 80 Celsius degrees, and then a solid powder A1 is obtained after suction filtration and drying.", "(2) 60 grams of naphthaline is added into a coating pot and then the coating pot is heated to 90 Celsius degrees to dissolve the naphthaline, and then 8 grams of high temperature coal tar pitch (purchased from Shanghai Ding Yang Nai Cai Co., LTD) is added to obtain a naphthaline solution of high temperature coal tar pitch.", "Then the solid powder A1 is added into the naphthaline solution, and stirred under 90 Celsius degrees for 25 minutes, and then heated to 210 Celsius degrees and maintained for 2 hours, and then heated to 280 Celsius degrees and maintained for 1 hour, and then cooled down to room temperature (about 25 Celsius degrees) to obtain a solid powder B1.", "(3) The solid powder B1 is added into an atmosphere oven, and nitrogen is introduced into the atmosphere oven at a rate of 6 m3/h to expel oxygen, such that an oxygen content is lower than 50 ppm.", "Then the rate of introducing nitrogen is maintained lower than 0.3 m3/h, the atmosphere oven is heated to 300 Celsius degree with a heating rate of 5 Celsius degrees per minutes and maintained for 2 hours, then heated to 1050 Celsius degree with a heating rate of 10 Celsius degrees per minutes and maintained for 4 hours, and then naturally cooled down to room temperature (about 25 Celsius degrees) to obtain a solid powder C1.", "(4) The solid powder C1 is washed by deionized water for 3 times (a solid-to-liquid ratio in each time is 1:5), then an anode material having porous core-shell structure CA1 is obtained after filtration and drying.", "A field emission scanning electron micrograph of the anode material having porous core-shell structure CA1 is shown in FIG.", "1 and FIG.", "2, in which a particle diameter D50 of the anode material is 12.4 μm, a porosity of the anode material is 15%, a pore diameter is 100 nanometers, a thickness of carbon shell is 1 μm, a weight ratio of carbon element of the carbon shell to the core is 1:10, a weight ratio of cobalt element, tin element to carbon element in the carbon shell is 1:4:4, a particle diameter of cobaltous oxide contained is 30 nanometers, a particle diameter of tin oxide is 50 nanometers, and a particle diameter of tin cobalt alloy is 60 nanometers.", "Embodiment 2 This embodiment is used herein to illustrate the anode material of the present disclosure and its preparation method.", "The method in Embodiment 2 is similar to that in Embodiment 1, with exceptions that: The amount of calcium carbonate in step (1) is 0.5 grams.", "In step (2), the high temperature coal tar pitch is replaced with 15 grams of glucose, and naphthaline is replaced with 200 mL of deionized water, and 0.3 grams of carbon nano tube (LB200 purchased from Cnano Technology Co., LTD).", "In step (3), in the second heating stage, the atmosphere oven is heated to 750 Celsius degrees with a heating rate of 10 Celsius degrees per minutes.", "Thus, an anode material having porous core-shell structure CA2 is obtained.", "A particle diameter D50 of the anode material is 11.8 μm, a porosity of the anode material is 8%, a pore diameter is 80 nanometers, a thickness of carbon shell is 1.2 μm, a weight ratio of carbon element of the carbon shell to the core is 1:10, a weight ratio of cobalt element, tin element to carbon element in the carbon shell is 1:4:4, a particle diameter of cobaltous oxide contained is 30 nanometers, a particle diameter of tin oxide is 40 nanometers, and a particle diameter of tin cobalt alloy is 50 nanometers.", "Embodiment 3 This embodiment is used herein to illustrate the anode material of the present disclosure and its preparation method.", "The method in Embodiment 3 is similar to that in Embodiment 1, with exceptions that: The amount of calcium carbonate in step (1) is 2 grams.", "In step (2), the high temperature coal tar pitch is replaced with 8 grams of phenolic resin (RS-619 purchased from Shenzhen Puli Chemical Co., LTD), and naphthaline is replaced with 300 mL of absolute ethyl alcohol, and 1.5 grams of acetylene black (V7 purchased from CCBI).", "In step (3), in the second heating stage, the atmosphere oven is heated to 900 Celsius degrees with a heating rate of 10 Celsius degrees per minutes.", "Thus, an anode material having porous core-shell structure CA3 is obtained.", "A particle diameter D50 of the anode material is 12.1 μm, a porosity of the anode material is 28%, a pore diameter is 120 nanometers, a thickness of carbon shell is 1.3 μm, a weight ratio of carbon element of the carbon shell to the core is 1:10, a weight ratio of cobalt element, tin element to carbon element in the carbon shell is 1:4:4, a particle diameter of cobaltous oxide contained is 30 nanometers, a particle diameter of tin oxide is 40 nanometers, and a particle diameter of tin cobalt alloy is 50 nanometers.", "Embodiment 4 This embodiment is used herein to illustrate the anode material of the present disclosure and its preparation method.", "The method in Embodiment 4 is similar to that in Embodiment 1, with exceptions that: the heating process (namely the high temperature decomposition treatment) in step (3) is different, in Embodiment 4, the atmosphere oven is directly heated to 1050 Celsius degrees with a heating rate of 10 Celsius degrees per minutes and maintained for 4 hours.", "Thus, an anode material having porous core-shell structure CA4 is obtained.", "A particle diameter D50 of the anode material is 11.9 μm, a porosity of the anode material is 12%, a pore diameter is 150 nanometers, a thickness of carbon shell is 1.5 μm, a weight ratio of carbon element of the carbon shell to the core is 1:10, a weight ratio of cobalt element, tin element to carbon element in the carbon shell is 1:4:4, a particle diameter of cobaltous oxide contained is 50 nanometers, a particle diameter of tin oxide is 80 nanometers, and a particle diameter of tin cobalt alloy is 70 nanometers.", "Comparative Embodiment 1 The method in Comparative Embodiment 1 is similar to that in Embodiment 1, with exceptions that: no calcium carbonate is added, and the high temperature coal tar pitch is replaced with 20 grams of soluble starch.", "Thus, an anode material CB1 is obtained.", "A particle diameter D50 of the anode material is 12.1 μm, a porosity of the anode material is 0.5%, a pore diameter is 5 nanometers, a thickness of carbon shell is 0.8 μm, a weight ratio of carbon element of the carbon shell to the core is 1:10, a weight ratio of cobalt element, tin element to carbon element in the carbon shell is 1:2:4, a particle diameter of cobaltous oxide contained is 30 nanometers, a particle diameter of tin oxide is 40 nanometers, and a particle diameter of tin cobalt alloy is 50 nanometers.", "Test Embodiment 1 A button battery is prepared respectively with the anode materials of Embodiments 1-4 and Comparative Embodiment 1 via the following method: the anode material, acetylene black, CMC and SBR are mixed evenly and tableted, of which a mass ratio of the anode material, acetylene black, CMC to SBR is 100:2:1.5:2.5, and then a test electrode sheet is obtained after drying at a temperature of 120 Celsius degrees under vacuum for 24 hours.", "Batteries S1-S4 and DS1 are assembled respectively in a glove box filled with argon, of which a counter electrode is lithium metal piece, separator is celgard2400 porous polypropylene membrane, and an electrolyte is a mixing solution of LiPF6 (1 mol/L), ethylene carbonate (EC) and dimethyl carbonate (DMC) (a weight ratio of EC to DMC is 1:1).", "Test Method An intercalation lithium capacity, de-intercalation lithium capacity, intercalation lithium capacity after cycling for 50 times and de-intercalation lithium capacity after cycling for 50 times are measured through a method of charging and discharging of button batteries.", "Mass ratio capacity includes a mass ratio intercalation lithium capacity, and a mass ratio de-intercalation lithium capacity, a calculation method of the mass ratio intercalation lithium capacity and the mass ratio de-intercalation lithium capacity is obtained depending on calculating the intercalation lithium capacity and de-intercalation lithium capacity via using a ratio of measured de-intercalation and intercalation lithium capacity to a content of active material that actually coated on electrode sheet.", "The test results are shown in Table 1.TABLE 1 Intercalation Initial mass Initial mass lithium De-intercalation Capacity Initial Initial de- ratio ratio de- specific lithium specific retention intercalation intercalation intercalation intercalation capacity after capacity after ratio after lithium lithium Initial lithium lithium cycling for 50 cycling for 50 cycling for capacity capacity efficiency capacity capacity times times 50 times Battery mAh mAh % mAh/g mAh/g mAh/g mAh/g % S1 3.845 3.3226 86.41 438 378.49 326.09 325.12 85.9 S2 3.8253 3.3068 86.45 424.6 367.04 325.89 325.56 88.7 S3 3.8446 3.3191 86.33 426.28 368.02 311.92 310.98 84.5 S4 3.9602 3.3369 84.26 439.57 370.38 301.21 295.19 79.7 DS1 4.012 3.2358 80.65 445.41 359.22 248.92 246.43 68.6 Note: The efficiency refers to an efficiency of charging and discharging, which is a percentage of de-intercalation lithium capacity to intercalation lithium capacity.", "The capacity retention ratio refers to a percentage of de-intercalation lithium mass specific capacity after cycling for 50 times to initial de-intercalation lithium mass specific capacity.", "As we can see from Table 1, after cycling for 50 times, the batteries S1-S4 prepared from the anode material having porous core-shell structure of the present disclosure have a minimum intercalation lithium specific capacity of 301.21 mAh/g, and a minimum de-intercalation lithium specific capacity of 295.19 mAh/g, which are much greater than that of DS1 (248.92 mAh/g and 246.43 mAh/g).", "A maximum capacity retention ratio after cycling for 50 times of the batteries S1-S4 prepared from the anode material having porous core-shell structure of the present disclosure may reach 88.7%.", "That is, the battery prepared from the anode material having porous core-shell structure of the present disclosure may have a good recycle performance.", "Although explanatory embodiments stated above have been shown and described in detail, the present disclosure may not be limited to those details described in these embodiments, various simple modifications could be made within technical spirit and principles of the present disclosure, those simple modifications all fall into the protection scope of the present disclosure.", "In addition, it should be noted that, each specific technical feature described in these embodiments stated above, under no contradiction, could be combined via any appropriate manner, in order to avoid unnecessary repetition, various possible combination manners are not illustrated in the present disclosure.", "In addition, each different embodiment of the present disclosure could also be combined with each other without departing from spirit and principles of the present disclosure, which should also be deemed as content of present disclosure." ] ]
Patent_15874276
[ [ "RESOURCE SHARING IN A TELECOMMUNICATIONS ENVIRONMENT", "A transceiver is designed to share memory and processing power amongst a plurality of transmitter and/or receiver latency paths, in a communications transceiver that carries or supports multiple applications.", "For example, the transmitter and/or receiver latency paths of the transceiver can share an interleaver/deinterleaver memory.", "This allocation can be done based on the data rate, latency, BER, impulse noise protection requirements of the application, data or information being transported over each latency path, or in general any parameter associated with the communications system." ], [ "1.A method for sharing resources in a transceiver comprising: allocating a first portion of shared memory to a first latency path and allocating a second portion of the shared memory to a second latency path.", "2-45.", "(canceled)" ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>One difficulty with implementing multiple latency paths in a transceiver is the fact that a latency path is a complicated digital circuit that requires a large amount of memory and processing power.", "An interleaver within a latency path can consume a large amount of memory in order to provide error correcting capability.", "For example, a typical DSL transceiver will have at least one latency path with approximately 16 kbytes of memory for the interleaver.", "Likewise, the coding block, for example, a Reed Solomon coder, consumes a large amount of processing power.", "In general, as the number of latency paths increase, the memory and processing power requirements for a communication system become larger.", "Accordingly, an exemplary aspect of this invention relates to sharing memory between one or more interleavers and/or deinterleavers in a transceiver.", "More particularly, an exemplary aspect of this invention relates to shared latency path memory in a transceiver.", "Additional aspects of this invention relate to configuring and initializing shared memory in a communication system.", "More particularly, an exemplary aspect of this invention relates to configuring and initializing interleaver/deinterleaver memory in a communication system.", "Additional aspects of the invention relate to determining the amount of memory that can be allocated to a particular component by a communication system.", "More specifically, an exemplary aspect of the invention relates to determining the maximum amount of shared memory that can be allocated to one or more interleaves or deinterleavers.", "According to another exemplary aspect of the invention, processing power is shared between a number of transceiver modules.", "More specifically, and in accordance with an exemplary embodiment of the invention, a coding module is shared between one or more coders and/or decoders.", "Another exemplary embodiment of the invention relates to transitioning from a fixed memory configuration to a shared memory configuration during one or more of initialization and SHOWTIME (user data transmission).", "An additional exemplary aspect of the invention relates to dynamically updating one or more of shared memory and processing resources based on changing communication conditions.", "An additional exemplary aspect of the invention relates to updating one or more of shared memory and processing resources based on an updated communication parameter.", "An additional exemplary aspect of the invention relates to updating the allocation of one or more of shared memory and processing resources based on an updated communication parameter(s).", "Additional aspects of the invention relate to exchanging shared resource allocations between transceivers.", "Additional exemplary aspects relate to a method of allocating shared memory in a transceiver comprising allocating the shared memory to a plurality of modules, wherein each of the plurality of modules comprise at least one interleaver, at least one deinterleaver or a combination thereof.", "Still further aspects relate to the above method wherein the plurality of modules comprise interleavers.", "Still further aspects relate to the above method wherein the plurality of modules comprise deinterleavers.", "Still further aspects relate to the above method wherein the plurality of modules comprise at least one interleaver and at least one deinterleaver.", "Additional exemplary aspects relate to a transceiver comprising a plurality of modules each including at least one interleaver, at least one deinterleaver or a combination thereof and a shared memory designed to be allocated to a plurality of the modules.", "Still further aspects relate to the above transceiver wherein the plurality of modules comprise interleavers.", "Still further aspects relate to the above transceiver wherein the plurality of modules comprise deinterleavers.", "Still further aspects relate to the above transceiver wherein the plurality of modules comprise at least one interleaver and at least one deinterleaver.", "These and other features and advantages of this invention are described in, or are apparent from, the following description of the embodiments." ], [ "RELATED APPLICATION DATA This application is a Continuation of U.S. application Ser.", "No.", "14/081,469, filed Nov. 15, 2013, now U.S. Pat.", "No.", "9,069,718, which is a Continuation of U.S. application Ser.", "No.", "13/942,938, filed Jul.", "16, 2013, now U.S. Pat.", "No.", "8,607,126, which is a Continuation of U.S. application Ser.", "No.", "13/567,261, filed Aug. 6, 2012, now U.S. Pat.", "No.", "8,495,473, which is a Continuation of U.S. application Ser.", "No.", "12/901,699, filed Oct. 11, 2010, now U.S. Pat.", "No.", "8,276,048, which is a Continuation of Ser.", "No.", "12/761,586, filed Apr.", "16, 2010, now U.S. Pat.", "No.", "7,844,882, which is a Continuation of U.S. application Ser.", "No.", "11/246,163 filed Oct. 11, 2005, now U.S. Pat.", "No.", "7,831,890, which claims the benefit of and priority under 35 U.S.C.", "§ 119(e) to U.S. Patent Application No.", "60/618,269, filed Oct. 12, 2004, entitled “Sharing Memory and Processing Resources in DSL Systems,” each of which are incorporated herein by reference in their entirety.", "BACKGROUND Field of the Invention This invention generally relates to communication systems.", "More specifically, an exemplary embodiment of this invention relates to memory sharing in communication systems.", "Another exemplary embodiment relates to processing or coding resource sharing in a communication system.", "Description of Related Art U.S. Pat.", "Nos.", "6,775,320 and 6,778,596 describe DSL systems supporting multiple applications and multiple framer/coder/interleaver FCI blocks (an FCI block is also referred to as a latency path).", "DSL systems carry applications that have different transmission requirements with regard to, for example, data rate, latency (delay), bit error rate (BER), and the like.", "For example, video typically requires a low BER (<1E-10) but can tolerate higher latency (>20 ms).", "Voice, on the other hand, typically requires a low latency (<1 ms) but can tolerate BER (>1E-3).", "As described in U.S. Pat.", "No.", "6,775,320, different applications can use different latency paths in order to satisfy the different application requirements of the communication system.", "As a result a transceiver must support multiple latency paths in order to support applications such as video, Internet access and voice telephony.", "When implemented in a transceiver, each of the latency paths will have a framer, coder, and interleaver block with different capabilities that depend on the application requirements.", "SUMMARY One difficulty with implementing multiple latency paths in a transceiver is the fact that a latency path is a complicated digital circuit that requires a large amount of memory and processing power.", "An interleaver within a latency path can consume a large amount of memory in order to provide error correcting capability.", "For example, a typical DSL transceiver will have at least one latency path with approximately 16 kbytes of memory for the interleaver.", "Likewise, the coding block, for example, a Reed Solomon coder, consumes a large amount of processing power.", "In general, as the number of latency paths increase, the memory and processing power requirements for a communication system become larger.", "Accordingly, an exemplary aspect of this invention relates to sharing memory between one or more interleavers and/or deinterleavers in a transceiver.", "More particularly, an exemplary aspect of this invention relates to shared latency path memory in a transceiver.", "Additional aspects of this invention relate to configuring and initializing shared memory in a communication system.", "More particularly, an exemplary aspect of this invention relates to configuring and initializing interleaver/deinterleaver memory in a communication system.", "Additional aspects of the invention relate to determining the amount of memory that can be allocated to a particular component by a communication system.", "More specifically, an exemplary aspect of the invention relates to determining the maximum amount of shared memory that can be allocated to one or more interleaves or deinterleavers.", "According to another exemplary aspect of the invention, processing power is shared between a number of transceiver modules.", "More specifically, and in accordance with an exemplary embodiment of the invention, a coding module is shared between one or more coders and/or decoders.", "Another exemplary embodiment of the invention relates to transitioning from a fixed memory configuration to a shared memory configuration during one or more of initialization and SHOWTIME (user data transmission).", "An additional exemplary aspect of the invention relates to dynamically updating one or more of shared memory and processing resources based on changing communication conditions.", "An additional exemplary aspect of the invention relates to updating one or more of shared memory and processing resources based on an updated communication parameter.", "An additional exemplary aspect of the invention relates to updating the allocation of one or more of shared memory and processing resources based on an updated communication parameter(s).", "Additional aspects of the invention relate to exchanging shared resource allocations between transceivers.", "Additional exemplary aspects relate to a method of allocating shared memory in a transceiver comprising allocating the shared memory to a plurality of modules, wherein each of the plurality of modules comprise at least one interleaver, at least one deinterleaver or a combination thereof.", "Still further aspects relate to the above method wherein the plurality of modules comprise interleavers.", "Still further aspects relate to the above method wherein the plurality of modules comprise deinterleavers.", "Still further aspects relate to the above method wherein the plurality of modules comprise at least one interleaver and at least one deinterleaver.", "Additional exemplary aspects relate to a transceiver comprising a plurality of modules each including at least one interleaver, at least one deinterleaver or a combination thereof and a shared memory designed to be allocated to a plurality of the modules.", "Still further aspects relate to the above transceiver wherein the plurality of modules comprise interleavers.", "Still further aspects relate to the above transceiver wherein the plurality of modules comprise deinterleavers.", "Still further aspects relate to the above transceiver wherein the plurality of modules comprise at least one interleaver and at least one deinterleaver.", "These and other features and advantages of this invention are described in, or are apparent from, the following description of the embodiments.", "BRIEF DESCRIPTION OF THE DRAWINGS The embodiments of the invention will be described in detail, with reference to the following figures, wherein: FIG.", "1 is a functional block diagram illustrating an exemplary transceiver according to this invention; FIG.", "2 is a flowchart outlining an exemplary method of sharing resources according to this invention; FIG.", "3 is a flowchart outlining an exemplary method of determining a maximum amount of shared memory according to this invention; and FIG.", "4 is a flowchart outlining an exemplary resource sharing methodology according to this invention.", "DETAILED DESCRIPTION The exemplary embodiments of this invention will be described in relation to sharing resources in a wired and/or wireless communications environment.", "However, it should be appreciated, that in general, the systems and methods of this invention will work equally well for any type of communication system in any environment.", "The exemplary systems and methods of this invention will also be described in relation to multicarrier modems, such as DSL modems and VDSL modems, and associated communication hardware, software and communication channels.", "However, to avoid unnecessarily obscuring the present invention, the following description omits well-known structures and devices that may be shown in block diagram form or otherwise summarized.", "For purposes of explanation, numerous details are set forth in order to provide a thorough understanding of the present invention.", "It should be appreciated however that the present invention may be practiced in a variety of ways beyond the specific details set forth herein.", "Furthermore, while the exemplary embodiments illustrated herein show the various components of the system collocated, it is to be appreciated that the various components of the system can be located at distant portions of a distributed network, such as a telecommunications network and/or the Internet, or within a dedicated secure, unsecured and/or encrypted system.", "Thus, it should be appreciated that the components of the system can be combined into one or more devices, such as a modem, or collocated on a particular node of a distributed network, such as a telecommunications network.", "As will be appreciated from the following description, and for reasons of computational efficiency, the components of the system can be arranged at any location within a distributed network without affecting the operation of the system.", "For example, the various components can be located in a Central Office modem (CO, ATU-C, VTU-O), a Customer Premises modem (CPE, ATU-R, VTU-R), a DSL management device, or some combination thereof.", "Similarly, one or more functional portions of the system could be distributed between a modem and an associated computing device.", "Furthermore, it should be appreciated that the various links, including communications channel 5, connecting the elements can be wired or wireless links, or any combination thereof, or any other known or later developed element(s) that is capable of supplying and/or communicating data to and from the connected elements.", "The term module as used herein can refer to any known or later developed hardware, software, firmware, or combination thereof that is capable of performing the functionality associated with that element.", "The terms determine, calculate and compute, and variations thereof, as used herein are used interchangeably and include any type of methodology, process, mathematical operation or technique.", "FCI block and latency path are used interchangeably herein as well as transmitting modem and transmitting transceiver.", "Receiving modem and receiving transceiver are also used interchangeably.", "FIG.", "1 illustrates an exemplary embodiment of a transceiver 100 that utilizes shared resources.", "It should be appreciated that numerous functional components of the transceiver have been omitted for clarity.", "However, the transceiver 100 can also include the standard components found in typical communications device(s) in which the technology of the subject invention is implemented into.", "According to an exemplary embodiment of the invention, memory and processing power can be shared among a plurality of transmitter and/or receiver latency paths, in a communications transceiver that carries or supports multiple applications.", "For example, the transmitter and/or receiver latency paths of the transceiver can share an interleaver/deinterleaver memory and the shared memory can be allocated to the interleaver and/or deinterleaver of each latency path.", "This allocation can be done based on the data rate, latency, BER, impulse noise protection requirements of the application, data or information being transported over each latency path, or in general any parameter associated with the communications system.", "Likewise, for example, the transmitter and/or receiver latency paths can share a Reed-Solomon coder/decoder processing module and the processing power of this module can be allocated to each encoder and/or decoder.", "This allocation can be done based on the data rate/latency, BER, impulse noise protection requirements of the application data or information being transported over each latency path, or in general based on any parameter associated with the communication system.", "In accordance with an exemplary operational embodiment, a first transceiver and a second transceiver transmit to one another messages during, for example, initialization which contain information on the total and/or shared memory capabilities of each transceiver and optionally information about the one or more latency paths.", "This information can be transmitted prior to determining how to configure the latency paths to support the application requirements.", "Based on this information, one of the modems can select an FCI configuration parameter(s) that meets the transmission requirements of each application being transported over each latency paths.", "While an exemplary of the embodiment of the invention will be described in relation to the operation of the invention and characteristics thereof being established during initialization, it should be appreciated that the sharing of resources can be modified and messages transmitted between a two transceivers at any time during initialization and/or user data transmission, i.e., SHOWTIME.", "FIG.", "1 illustrates an exemplary embodiment of a transceiver 100.The transceiver 100 includes a transmitter portion 200 and a receiver portion 300.The transmitter portion 200 includes one or more latency paths 210, 220, .", ".", ".", ".", "Similarly, the receiver portion 300 includes one or more latency paths 310, 320, .", ".", ".", ".", "Each of the latency paths in the transmitter portion 200 includes a framer, coder, and interleaver designated as 212, 214, 216 and 222, 224 and 226, respectively.", "Each of the latency paths in the receiver portion includes a deframer, decoder, and deinterleaver designated as 312, 314, 316 and 322, 324, and 326, respectively.", "The transceiver 100 further includes a shared processing module 110, a shared memory 120, a parameter determination module 130, a path module 140, an allocation module 150, and a shared resource management module 160, all interconnected by one or more links (not shown).", "In this exemplary embodiment, the transceiver 100 is illustrated with four total transmitter portion and receiver portion latency paths, i.e., 210, 220, 310, and 320.The shared memory 120 is shared amongst the two transmitter portion interleavers 216 and 226 and two receiver portion deinterleavers 316 and 326.The shared processing module 110, such as a shared coding module, is shared between the two transmitter portion coders 214 and 224 and the two receiver portion decoders 314 and 324.While the exemplary embodiment of the invention will be described in relation to a transceiver having a number of transmitter portion latency paths and receiver portion latency paths, it should be appreciated that this invention can be applied to any transceiver having any number of latency paths.", "Moreover, it should be appreciated that the sharing of resources can be allocated such that one or more of the transmitter portion latency paths are sharing a shared resource, one or more of the receiver portion latency paths are sharing a shared resource, or a portion of the transmitter portion latency paths and a portion of the receiver portion latency paths are sharing shared resources.", "Moreover, any one or more of the latency paths, or portions thereof, could also be assigned to a fixed resource while, for example, another portion of the latency path(s) assigned to a shared resource.", "For example, in latency path 210, the interleaver 216 could be allocated a portion of the shared memory 120, while the coder 214 could be allocated to a dedicated processing module, vice versa, or the like.", "In accordance with the exemplary embodiment, a plurality of transmitter portion or receiver portion latency paths share an interleaver/deinterleaver memory, such as shared memory 120, and a coding module, such as shared processing module 110.For example, the interleaver/deinterleaver memory can be allocated to different interleavers and/or deinterleavers.", "This allocation can be based on parameters associated with the communication systems such as data rate, latency, BER, impulse noise protection, and the like, of the applications being transported.", "Similarly, a coding module, which can be a portion of the shared processing module 110, can be shared between any one or more of the latency paths.", "This sharing can be based on requirements such as data rate, latency, BER, impulse noise protection, and the like, of the applications being transported.", "For example, an exemplary transceiver could comprise a shared interleaver/deinterleaver memory and could be designed to allocate a first portion of the shared memory 120 to an interleaver, such as interleaver 216 in the transmitter portion of the transceiver and allocate a second portion of the shared memory 120 to a deinterleaver, such as 316, in the receiver portion of the transceiver.", "Alternatively, for example, an exemplary transceiver can comprise a shared interleaver/deinterleaver memory, such as shared memory 120, and be designed to allocate a first portion of shared memory 120 to a first interleaver, e.g., 216, in the transmitter portion of the transceiver and allocate a second portion of the shared memory to a second interleaver, e.g., 226, in the transmitter portion of the transceiver.", "Alternatively, for example, an exemplary transceiver can comprise a shared interleaver/deinterleaver memory and be designed to allocate a first portion of the shared memory 120 to a first deinterleaver, e.g., 316, in the receiver portion of the transceiver and allocate a second portion of the shared memory to a second deinterleaver, e.g., 326, in the receiver portion of the transceiver.", "Regardless of the configuration, in general any interleaver or deinterleaver, or grouping thereof, be it in a transmitter portion or receiver portion of the transceiver, can be associated with a portion of the shared memory 120.Establishment, configuration and usage of shared resources is performed in the following exemplary manner.", "First, and in cooperation with the path module 140, the number of transmitter and receiver latency paths (N) is determined.", "The parameter determination module 130 then analyses one or more parameters such as data rate, transmitter data rate, receiver data rate, impulse noise protection, bit error rate, latency, or the like.", "Based on one or more of these parameters, the allocation module 150 allocates a portion of the shared memory 120 to one or more of the interleaver and/or deinterleavers, or groupings thereof.", "This process continues until the memory allocation has been determined and assigned to each of the N latency paths.", "Having determined the memory allocation for each of the latency paths, and in conjunction with the shared resource management 160, the transceiver 100 transmits to a second transceiver one or more of the number of latency paths (N), the maximum interleaver memory for any one or more of the latency paths and/or the maximum total and/or shared memory for all of the latency paths.", "Three examples of sharing interleaver/deinterleaver memory and coding processing in a transceiver are described below.", "The latency paths in these examples can be in the transmitter portion of the transceiver or the receiver portion of the transceiver.", "Example #1 A first transmitter portion or receiver portion latency path may carry data from a video application, which needs a very low BER but can tolerate higher latency.", "In this case, the video will be transported using an latency path that has a large amount of interleaving/deinterleaving and coding (also known as Forward Error Correction (FEC) coding).", "For example, the latency path may be configured with Reed-Solomon coding using a codeword size of 255 bytes (N=255) with 16 checkbytes (R=16) and interleaving/deinterleaving using an interleaver depth of 64 (D=64).", "This latency path will require N*D=255*64=16 Kbytes of interleaver memory at the transmitter (or deinterleaver memory at the receiver).", "This latency path will be able to correct a burst of errors that is less than 512 bytes in duration.", "A second transmitter portion or receiver portion latency path may carry an internet access application that requires a medium BER and a medium amount of latency.", "In this case, the internet access application will be transported using a latency path that has a medium amount of interleaving and coding.", "For example, the latency path may be configured with Reed-Solomon coding using a codeword size of 128 bytes (N=128) with 8 checkbytes (R=8) and interleaving using an interleaver depth of 16 (D=32).", "This latency path will require N*D=128*32=4 Kbytes of interleaver memory and the same amount of deinterleaver memory.", "This latency path will be able to correct a burst of errors that is less than 128 bytes in duration.", "A third transmitter portion or receiver portion latency path may carry a voice telephony application, which needs a very low latency but can tolerate BER.", "In this case, the video will be transported using an latency path that has a large amount of interleaving and coding.", "For example, the third transmitter portion or receiver portion latency path may be configured with no interleaving or coding which will result in the lowest possible latency through the latency path but will provide no error correction capability.", "According to the principles of this invention, a system carrying the three applications described above in Example #1, would have three latency paths that share one memory space containing at least (16+4)=20 Kbytes.", "The three latency paths also share a common coding block that is able to simultaneously encode (in the transmitter portion) or decode (in a receiver portion) two codewords with N=255/R=16 and N=128/R=8.According to an exemplary embodiment of this invention, the latency paths can be reconfigured at initialization or during data transmission mode (also known as SHOWTIME in ADSL and VDSL transceivers).", "This would occur if, for example, the applications or application requirements were to change.", "Example #2 If instead of 1 video application, 1 internet application and 1 voice application, there were 3 internet access applications then the transmitter portion and/or receiver portion latency paths would be reconfigured to utilize the shared memory and coding module in a different way.", "For example, the system could be reconfigured to have 3 transmitter portion or receiver portion latency paths, with each latency path being configured with Reed-Solomon coding using a codeword size of 128 bytes (N=128) with 8 checkbytes (R=8) and interleaving using an interleaver depth of 16 (D=32).", "Each latency path will require N*D=128*32=4 Kbytes of interleaver memory and each block will be able to correct a burst of errors that is less than 128 bytes in duration.", "Based on the example of carrying the three internet access applications described, the three latency path share one memory space containing at least 3*4=12 Kbytes.", "Also the three latency paths share a common coding block that is able to simultaneously encode (on the transmitter side) or decode (on the receiver side) three codewords with N=128/R=16, N=128/R=8 and N=128/R=8.Example #3 The system could be configured to carry yet another set of applications.", "For example, the latency paths could be configured to carry 2 video applications.", "In this case only 2 transmitter portion or receiver portion latency paths are needed, which means that the third latency path could be simply disabled.", "Also, assuming that the memory is constrained based on the first example above, then the maximum shared memory for these 2 latency paths is 20 kBytes.", "In this case, the system could be reconfigured to have 2 latency paths, with each block being configured with Reed-Solomon coding using a codeword size of 200 bytes (N=200) with 10 checkbytes (R=10) and interleaving/deinterleaving using an interleaver depth of 50 (D=50).", "Each latency path will require N*D=200*50=10 Kbytes of interleaver memory and each block will be able to correct a burst of errors that is less than 250 bytes in duration.", "This configuration results in 20K of shared memory for both latency paths, which is the same as in the first example.", "In order to stay within the memory constraints of the latency paths, the error correction capability for each latency path is decreased to 250 bytes from 512 bytes in Example #1.Another aspect of this invention is the how FCI configuration information is transmitted between a first modem and a second modem.", "FCI configuration information will depend on the requirements of the applications being transported over the DSL connection.", "This information may need to be forwarded during initialization in order to initially configure the DSL connection.", "This information may also need to be forwarded during SHOWTIME in order to reconfigure the DSL connection based on a change in applications or the application requirements.", "According to one embodiment, a first modem determines the specific FCI configuration parameters, e.g., N, D, R as defined above, needed to meet specific application requirements, such as latency, burst error correction capability, etc.", "In order to determine the FCI configuration parameters, the first modem must know what are the capabilities of a second modem.", "For example, the first modem must know how many latency paths (FCI blocks) the second modem can support.", "Also the first modem must know the maximum amount of interleaver memory for each transmitter latency path.", "In addition, since the transmitter latency paths may share a common memory space the first modem must know the total shared memory for all transmitter latency paths.", "This way the first modem will be able to choose a configuration that can meet application requirements and also meet the transmitter portion latency path capabilities of the second modem.", "For example, using values from examples above, a first transceiver could send a message to a second transceiver during initialization or during SHOWTIME containing the following information: Number of supported transmitter and receiver latency paths=3 Max Interleaver Memory for latency path #1=16 Kbytes Max Interleaver Memory for latency path #2=16 Kbytes Max Interleaver Memory for latency path #3=16 Kbytes Maximum total/shared memory for all latency paths=20 kBytes Based on this information, and the application requirements, the first transceiver would select latency path settings.", "For example, if the applications are 1 video, 1 internet access and 1 voice application, the first transceiver could conFIG.", "3 latency paths as follows: latency path #1—Video: N=255, R=16, D=64 latency path #2—Video: N=128, R=8, D=32 latency path #3—Video: N=0, R=0, D=1 (no coding or interleaving) This would result in a total interleaver memory of 20 kbytes.", "Alternatively, if for example, there are only 2 video applications, the first transceiver could configure 2 latency paths as follows: latency path #1—Video: N=200, R=10, D=50 latency path #2—Video: N=200, R=10, D=50 latency path #3—Video: N=0, R=0, D=1 (no coding or interleaving) This would also result in a total interleaver memory of 20 kbytes.", "Alternatively, the second transceiver can determine the specific FCI configuration parameters, e.g., N, D, R as defined above, needed to meet specific application requirements, such as latency, burst error correction capability, etc.", "As described above for the first transceiver, in order to determine the FCI configuration parameters, the second transceiver must first know what are the capabilities of the first transceiver.", "In this case, the first transceiver would send a message to the second transceiver containing the information described above and based on this information and the application requirements the second transceiver would select latency path settings.", "FIG.", "2 outlines an exemplary method of allocating shared memory in a transceiver.", "More specifically, control begins in step S200 and continues to step S210.In step S210, one or more of shared interleaver/deinterleaver memory and/or shared coder/decoder processing resources are allocated to one or more latency paths, in a transceiver.", "Control then continues to step S220 where the control sequence ends.", "FIG.", "3 outlines an exemplary method of exchanging shared resource allocations according to an exemplary embodiment of this invention.", "In particular, control begins in step S310.In step S310, a maximum amount of shared memory that can be allocated to a specific interleaver or deinterleaver of a plurality of interleavers or deinterleavers in a transceiver is determined.", "Next, in step S320, the determined maximum amount for one or more of the deinterleavers and/or interleavers is transmitted to another transceiver.", "Messages containing additional information can also be transmitted to the other transceiver and/or received from the other transceiver.", "Control then continues to step S330 where the control sequence ends.", "FIG.", "4 outlines an exemplary procedure for resource sharing according to an exemplary embodiment of this invention.", "In particular, control begins in step S400 and continues to step S410.In step S410, the number of latency paths are determined.", "Then, in step S420, the latency path information (FCI block information) is transmitted to another transceiver.", "Messages containing additional information can also be transmitted to the other transceiver and/or received from the other transceiver.", "This information can be used to, for example, assist with the determination of memory allocation in the transceiver.", "Moreover, the messages received from the other transceiver could specify what the memory allocation is to be based on, for example, the number of latency paths, memory allocation in the remote transceiver and required applications.", "Control then continues to step S430.In step S430, and for each latency path, the steps in step 440 are performed.", "In step S440, and while monitoring of allocation of resources is being performed, steps 450 and 460 are performed.", "More specifically, in step S450, one or more parameters associated with the communication system are determined.", "Then, in step S460, shared resources are allocated based on one or more of the communication parameters.", "Control then continues to step S470.In step S470, the allocation of shared resources is communicated to another transceiver.", "Next, in step S480, a determination is made as to whether there is a change in communications that would require the adjustment of the shared resource allocation.", "Examples of changes in communications conditions include a change in applications being transported over the system and/or changes in the channel condition, etc.", "If adjustments are required, control jumps back to step S410.Otherwise, control jumps to step S490 where the control sequence ends.", "The above-described system can be implemented on wired and/or wireless telecommunications devices, such a modem, a multicarrier modem, a DSL modem, an ADSL modem, an XDSL modem, a VDSL modem, a linecard, test equipment, a multicarrier transceiver, a wired and/or wireless wide/local area network system, a satellite communication system, a modem equipped with diagnostic capabilities, or the like, or on a separate programmed general purpose computer having a communications device or in conjunction with any of the following communications protocols: CDSL, ADSL2, ADSL2+, VDSL1, VDSL2, HDSL, DSL Lite, IDSL, RADSL, SDSL, UDSL or the like.", "Additionally, the systems, methods and protocols of this invention can be implemented on a special purpose computer, a programmed microprocessor or microcontroller and peripheral integrated circuit element(s), an ASIC or other integrated circuit, a digital signal processor, a hard-wired electronic or logic circuit such as discrete element circuit, a programmable logic device such as PLD, PLA, FPGA, PAL, a modem, a transmitter/receiver, any comparable means, or the like.", "In general, any device capable of implementing a state machine that is in turn capable of implementing the methodology illustrated herein can be used to implement the various communication methods, protocols and techniques according to this invention.", "Furthermore, the disclosed methods may be readily implemented in software using object or object-oriented software development environments that provide portable source code that can be used on a variety of computer or workstation platforms.", "Alternatively, the disclosed system may be implemented partially or fully in hardware using standard logic circuits or VLSI design.", "Whether software or hardware is used to implement the systems in accordance with this invention is dependent on the speed and/or efficiency requirements of the system, the particular function, and the particular software or hardware systems or microprocessor or microcomputer systems being utilized.", "The communication systems, methods and protocols illustrated herein can be readily implemented in hardware and/or software using any known or later developed systems or structures, devices and/or software by those of ordinary skill in the applicable art from the functional description provided herein and with a general basic knowledge of the computer and telecommunications arts.", "Moreover, the disclosed methods may be readily implemented in software that can be stored on a storage medium, executed on programmed general-purpose computer with the cooperation of a controller and memory, a special purpose computer, a microprocessor, or the like.", "In these instances, the systems and methods of this invention can be implemented as program embedded on personal computer such as an applet, JAVA® or CGI script, as a resource residing on a server or computer workstation, as a routine embedded in a dedicated communication system or system component, or the like.", "The system can also be implemented by physically incorporating the system and/or method into a software and/or hardware system, such as the hardware and software systems of a communications transceiver.", "It is therefore apparent that there has been provided, in accordance with the present invention, systems and methods for sharing resources.", "While this invention has been described in conjunction with a number of embodiments, it is evident that many alternatives, modifications and variations would be or are apparent to those of ordinary skill in the applicable arts.", "Accordingly, it is intended to embrace all such alternatives, modifications, equivalents and variations that are within the spirit and scope of this invention." ] ]
Patent_15874277
[ [ "DATA PROCESSING DEVICE AND DRIVING METHOD THEREOF", "A data processing device which includes a flexible position input portion for sensing proximity or a touch of an object such as a user's palm and finger.", "In the case where a first region of the flexible position input portion is held by a user for a certain period, supply of image signals to the first region is selectively stopped." ], [ "1.A portable device comprising: a display panel configured to display an image over a front surface and a first side surface of the portable device; a sensor portion configured to sense touch of an object over the front surface and the first side surface of the portable device; and an arithmetic portion configured to determine whether touch in a region of the display panel corresponds to an intentional input of a user and selectively stop supply of an image signal to the region, wherein a part of the display panel is curved toward a back surface of the portable device, and wherein the arithmetic portion is mounted over the part of the display panel.", "2.The portable device according to claim 1, wherein touch in the region is identified as an unintentional input when the portable device is held by the user for a certain period.", "3.The portable device according to claim 1, wherein the part of display panel is curved in conformity with the first side surface of the portable device.", "4.The portable device according to claim 1, wherein the arithmetic portion is on and in contact with the part of the display panel.", "5.The portable device according to claim 1, wherein the display panel is configured to display the image over a second side surface opposite to the first side surface of the portable device.", "6.A portable device comprising: a display panel configured to display an image over a front surface and a first side surface of the portable device; a sensor portion configured to sense touch of an object over the front surface and the first side surface of the portable device; and an arithmetic portion configured to determine whether touch in a region of the display panel corresponds to an intentional input of a user and selectively stop supply of an image signal to the region, wherein a part of the display panel is curved toward a back surface of the portable device, wherein the sensor portion comprises a plurality of sensors over a flexible substrate, wherein a part of the flexible substrate is curved toward the back surface of the portable device, and wherein the arithmetic portion is mounted over the part of the display panel.", "7.The portable device according to claim 6, wherein touch in the region is identified as an unintentional input when the portable device is held by the user for a certain period.", "8.The portable device according to claim 6, wherein the part of display panel is curved in conformity with the first side surface of the portable device.", "9.The portable device according to claim 6, wherein the arithmetic portion is on and in contact with the part of the display panel.", "10.The portable device according to claim 6, wherein the display panel is configured to display the image over a second side surface opposite to the first side surface of the portable device.", "11.A portable device comprising: a display panel configured to display an image over a front surface and a first side surface of the portable device; a sensor portion configured to sense touch of an object over the front surface and the first side surface of the portable device; and an arithmetic portion configured to determine whether touch in a region of the display panel corresponds to an intentional input of a user and selectively stop supply of an image signal to the region, wherein a part of the display panel is curved toward a back surface of the portable device, wherein the arithmetic portion is mounted over the part of the display panel, and wherein the display panel is folded in three such that a first portion, a second portion, and a third portion of the display panel overlap with each other.", "12.The portable device according to claim 11, wherein touch in the region is identified as an unintentional input when the portable device is held by the user for a certain period.", "13.The portable device according to claim 11, wherein the part of display panel is curved in conformity with the first side surface of the portable device.", "14.The portable device according to claim 11, wherein the arithmetic portion is on and in contact with the part of the display panel.", "15.The portable device according to claim 11, wherein the display panel is configured to display the image over a second side surface opposite to the first side surface of the portable device.", "16.The portable device according to claim 11, wherein the display panel is folded between the first portion and the second portion and between the second portion and the third portion." ], [ "<SOH> BACKGROUND ART <EOH>Display devices with large screens can display many pieces of information.", "Therefore, such display devices are excellent in browsability and suitable for information processors.", "The social infrastructures relating to means for transmitting information have advanced.", "This has made it possible to acquire, process, and send out many pieces and various kinds of information with the use of an information processor not only at home or office but also at other visiting places.", "With this being the situation, portable information processors are under active development.", "For example, portable information processors are often used outdoors, and force might be accidentally applied by dropping to the information processors and display devices included in them.", "As an example of a display device that is not easily broken, a display device having high adhesiveness between a structure body by which a light-emitting layer is divided and a second electrode layer is known (Patent Document 1)." ], [ "<SOH> BRIEF DESCRIPTION OF DRAWINGS <EOH>FIG.", "1 is a block diagram illustrating a structure of a data processing device of an embodiment.", "FIGS.", "2A to 2E illustrate structures of a data processing device and a position input portion of an embodiment.", "FIGS.", "3A to 3C illustrate structures of a data processing device and a position input portion of an embodiment.", "FIGS.", "4A to 4H illustrate structures of a data processing device and a position input portion of an embodiment.", "FIGS.", "5A and 5B are schematic views illustrating a structure of a data processing device of an embodiment.", "FIGS.", "6A and 6B are schematic views illustrating a structure of a data processing device of an embodiment.", "FIGS.", "7 A 1 , 7 A 2 , 7 B 1 , and 7 B 2 are schematic views illustrating structures of data processing devices of embodiments.", "FIGS.", "8 A 1 , 8 A 2 , 8 B 1 , and 8 B 2 are schematic views illustrating structures of data processing device of embodiments.", "FIGS.", "9 A 1 , 9 A 2 , 9 B 1 , and 9 B 2 are schematic views illustrating a structure of data processing devices of embodiments.", "FIGS.", "10 A 1 , 10 A 2 , and 10 B illustrate a structure of a position input portion of an embodiment.", "FIG.", "11 is a block diagram illustrating a structure of a data processing device of an embodiment.", "FIG.", "12A illustrates a structure of a data processing device of an embodiment, and FIGS.", "12B and 12C illustrate an unfolded state and an folded state of the data processing device.", "FIGS.", "13A to 13E illustrate a structure of a data processing device of an embodiment.", "FIGS.", "14 A 1 , 14 A 2 , 14 B 1 , and 14 B 2 illustrate a data processing device of an embodiment held by a user.", "FIGS.", "15A and 15B illustrate a data processing device of an embodiment held by a user.", "FIGS.", "16A and 16B are flow charts showing a program to be executed by an arithmetic portion of a data processing device of an embodiment.", "FIGS.", "17A to 17C illustrate structures of a data processing device and a position input portion of an embodiment FIGS.", "18A to 18D illustrate structures of a data processing device and a position input portion of an embodiment.", "FIGS.", "19A and 19B illustrate application examples of a data processing device of an embodiment.", "FIG.", "20 is a flow chart showing a program to be executed by an arithmetic portion of a data processing device of an embodiment.", "FIGS.", "21A to 21C illustrate an example of an image displayed on a display portion of a data processing device of an embodiment.", "FIG.", "22 is a flow chart showing a program to be executed by an arithmetic portion of a data processing device in one embodiment.", "FIG.", "23 is a flow chart showing a program to be executed by an arithmetic portion of a data processing device of one embodiment.", "FIG.", "24 is a flow chart showing a program to be executed by an arithmetic portion of a data processing device of one embodiment.", "FIG.", "25 illustrates an application example of a data processing device of an embodiment.", "FIGS.", "26A to 26C illustrate structures of a display panel that can be used for a display device of an embodiment.", "FIGS.", "27A and 27B illustrate a structure of a display panel that can be used for a display device of an embodiment.", "FIG.", "28 illustrates a structure of a display panel that can be used for a display device of an embodiment.", "FIGS.", "29A to 29D illustrate a method for manufacturing a foldable functional element of one embodiment.", "FIGS.", "30A to 30D illustrate a method for manufacturing a foldable functional element of an embodiment.", "FIGS.", "31A to 31D illustrate a method for manufacturing a foldable functional element of an embodiment.", "FIGS.", "32A and 32B illustrate application examples of a data processing device of an embodiment.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "TECHNICAL FIELD The present invention relates to an object, a method, or a manufacturing method.", "In addition, the present invention relates to a process, a machine, manufacture, or a composition of matter.", "In particular, the present invention relates to, for example, a semiconductor device, a display device, a light-emitting device, a power storage device, a driving method thereof, or a manufacturing method thereof.", "In particular, the present invention relates to, for example, a method and a program for processing and displaying image information, and a device including a recording medium in which the program is recorded.", "In particular, the present invention relates to, for example, a method for processing and displaying image information by which an image including information processed by an information processor provided with a display portion is displayed, a program for displaying an image including information processed by an information processor provided with a display portion, and an information processor including a recording medium in which the program is recorded.", "BACKGROUND ART Display devices with large screens can display many pieces of information.", "Therefore, such display devices are excellent in browsability and suitable for information processors.", "The social infrastructures relating to means for transmitting information have advanced.", "This has made it possible to acquire, process, and send out many pieces and various kinds of information with the use of an information processor not only at home or office but also at other visiting places.", "With this being the situation, portable information processors are under active development.", "For example, portable information processors are often used outdoors, and force might be accidentally applied by dropping to the information processors and display devices included in them.", "As an example of a display device that is not easily broken, a display device having high adhesiveness between a structure body by which a light-emitting layer is divided and a second electrode layer is known (Patent Document 1).", "REFERENCE [Patent Document 1] Japanese Published Patent Application No.", "2012-190794 DISCLOSURE OF INVENTION An object of one embodiment of the present invention is to provide a novel human interface with high operability.", "Another object is to provide a novel data processing device with high operability.", "Another object is to provide a novel processing device, a novel display device, or the like.", "Another object is to provide a data processing device, a display device, or the like which consumes low power.", "Another object is to provide a data processing device, a display device, or the like with favorable operability.", "Another object is to provide a data processing device, a display device, or the like which can be easily held by a user.", "Another object is to provide a data processing device, a display device, or the like which is less likely to fall.", "Another object is to provide a data processing device, a display device, or the like with fewer malfunctions.", "Another object is to provide a data processing device and a display device that can be easily operated with both hands.", "Note that the descriptions of these objects do not disturb the existence of other objects.", "In one embodiment of the present invention, there is no need to achieve all the objects.", "Other objects will be apparent from and can be derived from the description of the specification, the drawings, the claims, and the like.", "One embodiment of the present invention is a data processing device including an input/output unit that supplies positional data and receives image data, an arithmetic unit that receives the positional data and supplies the image data.", "The input/output unit includes a position input portion and a display portion.", "The position input portion is flexible to be bent such that a first region, a second region facing the first region, and a third region between the first region and the second region are formed.", "The display portion is provided to overlap with at least part of the first region, the second region, or the third region.", "The arithmetic unit includes an arithmetic portion and a memory portion that stores a program to be executed by the arithmetic portion, and supplies image data to the display portion based on the positional data.", "Another embodiment of the present invention is a data processing device including an input unit having a plurality of regions provided with a sensor portion that senses proximity or a touch of the object, an arithmetic portion that determines a proximity operation or a contact operation over a sensor portion, and a display device having flexibility.", "In the case where the specific proximity operation or contact operation is performed in the plurality of regions at the same time, predetermined processing is carried out.", "One embodiment of the present invention is a method for driving a data processing device including an input unit provided with a sensor portion that senses proximity or a touch of an object and a display unit provided with a display portion for displaying images.", "The sensor portion and the display portion overlaps with each other.", "The data processing device determines the first region over the sensor portion in which proximity or touch of an object is sensed for a predetermined time, and image signals are not provided to the second region over the display portion which overlaps with the first region.", "Another embodiment of the present invention is a driving method of a data processing device including an input unit provided with a sensor portion for sensing proximity or a touch of an object, and an arithmetic portion for determining a proximity operation or a contact operation over the sensor portion.", "The data processing device detects a region over the sensor portion in which proximity or contact of an object is sensed for a predetermined time is determined, so that the region is excluded from a subject of determination of the proximity operation or the contact operation.", "Another embodiment of the present invention is a driving method of a data processing device in which whether the data processing device is operated by one hand or whether it is operated with both hands is determined, and an image based on the determination result is displayed.", "In one embodiment of the present invention, a human interface with high operability can be provided.", "Furthermore, a novel data processing device with high operability can be provided.", "A novel data processing device or a novel display device can be provided.", "Furthermore, a data processing device, a display device, and the like which consume low power can be provided.", "A data processing device, a display device, and the like with high operability can be provided.", "A data processing device, display device, and the like which can be held easily can be provided.", "A data processing device, a display device, and the like which are less likely to fall can be provided.", "A data processing device, a display device, and the like with fewer malfunctions can be provided.", "A data processing device, a display device, and the like which is easily operated by both hands can be provided.", "Note that the description of these effects does not disturb the existence of other effects.", "One embodiment of the present invention does not necessarily achieve all the objects listed above.", "Other effects will be apparent from and can be derived from the description of the specification, the drawings, the claims, and the like.", "BRIEF DESCRIPTION OF DRAWINGS FIG.", "1 is a block diagram illustrating a structure of a data processing device of an embodiment.", "FIGS.", "2A to 2E illustrate structures of a data processing device and a position input portion of an embodiment.", "FIGS.", "3A to 3C illustrate structures of a data processing device and a position input portion of an embodiment.", "FIGS.", "4A to 4H illustrate structures of a data processing device and a position input portion of an embodiment.", "FIGS.", "5A and 5B are schematic views illustrating a structure of a data processing device of an embodiment.", "FIGS.", "6A and 6B are schematic views illustrating a structure of a data processing device of an embodiment.", "FIGS.", "7A1, 7A2, 7B1, and 7B2 are schematic views illustrating structures of data processing devices of embodiments.", "FIGS.", "8A1, 8A2, 8B1, and 8B2 are schematic views illustrating structures of data processing device of embodiments.", "FIGS.", "9A1, 9A2, 9B1, and 9B2 are schematic views illustrating a structure of data processing devices of embodiments.", "FIGS.", "10A1, 10A2, and 10B illustrate a structure of a position input portion of an embodiment.", "FIG.", "11 is a block diagram illustrating a structure of a data processing device of an embodiment.", "FIG.", "12A illustrates a structure of a data processing device of an embodiment, and FIGS.", "12B and 12C illustrate an unfolded state and an folded state of the data processing device.", "FIGS.", "13A to 13E illustrate a structure of a data processing device of an embodiment.", "FIGS.", "14A1, 14A2, 14B1, and 14B2 illustrate a data processing device of an embodiment held by a user.", "FIGS.", "15A and 15B illustrate a data processing device of an embodiment held by a user.", "FIGS.", "16A and 16B are flow charts showing a program to be executed by an arithmetic portion of a data processing device of an embodiment.", "FIGS.", "17A to 17C illustrate structures of a data processing device and a position input portion of an embodiment FIGS.", "18A to 18D illustrate structures of a data processing device and a position input portion of an embodiment.", "FIGS.", "19A and 19B illustrate application examples of a data processing device of an embodiment.", "FIG.", "20 is a flow chart showing a program to be executed by an arithmetic portion of a data processing device of an embodiment.", "FIGS.", "21A to 21C illustrate an example of an image displayed on a display portion of a data processing device of an embodiment.", "FIG.", "22 is a flow chart showing a program to be executed by an arithmetic portion of a data processing device in one embodiment.", "FIG.", "23 is a flow chart showing a program to be executed by an arithmetic portion of a data processing device of one embodiment.", "FIG.", "24 is a flow chart showing a program to be executed by an arithmetic portion of a data processing device of one embodiment.", "FIG.", "25 illustrates an application example of a data processing device of an embodiment.", "FIGS.", "26A to 26C illustrate structures of a display panel that can be used for a display device of an embodiment.", "FIGS.", "27A and 27B illustrate a structure of a display panel that can be used for a display device of an embodiment.", "FIG.", "28 illustrates a structure of a display panel that can be used for a display device of an embodiment.", "FIGS.", "29A to 29D illustrate a method for manufacturing a foldable functional element of one embodiment.", "FIGS.", "30A to 30D illustrate a method for manufacturing a foldable functional element of an embodiment.", "FIGS.", "31A to 31D illustrate a method for manufacturing a foldable functional element of an embodiment.", "FIGS.", "32A and 32B illustrate application examples of a data processing device of an embodiment.", "BEST MODE FOR CARRYING OUT THE INVENTION Embodiments will be described in detail with reference to drawings.", "Note that the present invention is not limited to the description below, and it is easily understood by those skilled in the art that various changes and modifications can be made without departing from the spirit and scope of the present invention.", "Accordingly, the present invention should not be interpreted as being limited to the content of the embodiments below.", "Note that in the structures of the invention described below, the same portions or portions having similar functions are denoted by the same reference numerals in different drawings, and description of such portions is not repeated.", "The position, size, range, and the like of each component illustrated in the drawings and the like are not accurately represented in some cases to facilitate understanding of the invention.", "Therefore, the disclosed invention is not necessarily limited to the position, the size, the range, or the like disclosed in the drawings and the like.", "For example, the position, size, range, and the like of each component are not illustrated in some cases for easy understanding.", "Note that the term “over” or “below” in this specification and the like does not necessarily mean that a component is placed directly on or directly below and directly in contact with another component.", "For example, the expression “electrode B over insulating layer A” does not necessarily mean that the electrode B is on and in direct contact with the insulating layer A and can mean the case where another component is provided between the insulating layer A and the electrode B.", "Note that ordinal numbers such as “first” and “second” and the like in this specification and the like are used in order to avoid confusion among components and do not denote the priority or the order such as the order of steps or the stacking order.", "A term without an ordinal number in this specification and the like might be provided with an ordinal number in a claim in order to avoid confusion among components.", "In addition, a term with an ordinal number in this specification and the like may be provided with a different ordinal number in a claim.", "In this specification and the like, “touch” means contacting with a surface of a data processing device by part of the body of a user such as a finger or a tool such as a stylus.", "In this specification and the like, “tap” means hitting the surface of the data processing device with part of the body of a user such as a finger or a tool such as a stylus.", "In this specification and the like, “flick” means sliding part of the body of a user or a tool such as a stylus on the surface of the data processing device.", "In this specification and the like, “drag” means selecting part or all of an image displayed on a display portion and moving the selected image by “flick” by part of the body of a user such as a finger or a tool such as a stylus.", "In this specification and the like, “pinch in” means sliding two fingers on the surface of the data processing device as if pinching an object.", "In this specification and the like, “pinch out” means sliding two fingers on the surface of the data processing device so that they are away from each other.", "In this specification and the like, a proximity operation and a contact operation performed over a sensor portion, such as “touch”, “tap”, “flick”, “drag”, “pinch in”, and “pinch out” are collectively referred to as “touch action”.", "Embodiment 1 In this embodiment, a structure of a data processing device of one embodiment of the present invention will be described with reference to drawings.", "FIG.", "1 shows a block diagram of a structure of a data processing device 100 of one embodiment of the present invention.", "FIG.", "2A is a schematic view illustrating the external appearance of the data processing device 100 of one embodiment of the present invention, and FIG.", "2B is a cross-sectional view illustrating a cross-sectional structure along a cutting-plane line X1-X2 in FIG.", "2A.", "FIGS.", "2C and 2D are schematic views illustrating the external appearance of the data processing device 100 of one embodiment of the present invention, and FIG.", "2E is a cross-sectional view illustrating a cross-sectional structure along a cutting-plane line X3-X4 in FIGS.", "2C and 2D.", "FIG.", "2C is a schematic view illustrating a front surface of the data processing device 100.FIG.", "2D is a schematic view illustrating a back surface of the data processing device 100.FIG.", "3A is a schematic view illustrating the external appearance of the data processing device 100 of one embodiment of the present invention, and FIG.", "3B is a cross-sectional view illustrating a cross-sectional structure along a cutting-plane line X5-X6 in FIG.", "3A.", "FIG.", "3C is a cross sectional view illustrating an example of a cross-sectional structure which is different from that of FIG.", "3B.", "FIG.", "4A is a schematic view illustrating the external appearance of the data processing device 100 of one embodiment of the present invention, and FIG.", "4B is a cross-sectional view illustrating a cross-sectional structure along a cutting-plane line X7-X8 in FIG.", "4A.", "FIGS.", "4C to 4H are cross-sectional views illustrating examples of cross-sectional structures which are different from those of FIG.", "4B.", "As illustrated in FIGS.", "2C and 2D, and FIG.", "3C, a position input portion 140 or a display portion 130 may be provided not only on the front surface but also on the side surface or the back surface of the data processing device 100.As illustrated in FIG.", "3A, the position input portion 140 or the display portion 130 may also be provided on the top surface of the data processing device 100.The position input portion 140 or the display portion 130 may also be provided on the bottom surface of the data processing device 100.As illustrated in FIG.", "4A and FIG.", "4B that is a cross-sectional view of FIG.", "4A, the position input portion 140 and the display portion 130 are not necessarily provided on the side surface, the top surface or the back surface of the data processing device 100.For example, a structure illustrated in FIGS.", "5A and 5B may be employed.", "FIG.", "5A is a schematic perspective view of the front surface side of the data processing device, and FIG.", "5B is a schematic perspective view of the back surface side thereof.", "Alternatively, a structure illustrated in FIGS.", "6A and 6B may be employed.", "FIG.", "6A is a schematic perspective view of the front surface side of the data processing device, and FIG.", "6B is a schematic perspective view of the back surface side thereof.", "Alternatively, a structure illustrated in FIGS.", "7A1 and 7A2 may be employed.", "FIG.", "7A1 is a schematic perspective view of the front surface side of the data processing device, and FIG.", "7A2 is a schematic perspective view of the back surface side thereof.", "In addition, a structure illustrated in FIGS.", "7B1 and 7B2 may be employed.", "FIG.", "7B1 is a schematic perspective view of the front surface side of the data processing device, and FIG.", "7B2 is a schematic perspective view of the back surface side thereof.", "In addition, a structure illustrated in FIGS.", "8A1 and 8A2 may be employed.", "FIG.", "8A1 is a schematic perspective view of the front surface side of the data processing device, and FIG.", "8A2 is a schematic perspective view of the back surface side thereof.", "In addition, a structure illustrated in FIGS.", "8B1 and 8B2 may be employed.", "FIG.", "8B1 is a schematic perspective view of the front surface side of the data processing device, and FIG.", "8B2 is a schematic perspective view of the back surface side thereof.", "In addition, a structure illustrated in FIGS.", "9A1 and 9A2 may be employed.", "FIG.", "9A1 is a schematic perspective view of the front surface side of the data processing device, and FIG.", "9A2 is a schematic perspective view of the back surface side thereof.", "In addition, a structure illustrated in FIGS.", "9B1 and 9B2 may be employed.", "FIG.", "9B1 is a schematic perspective view of the front surface side of the data processing device, and FIG.", "9B2 is a schematic perspective view of the back surface side thereof.", "Note that in addition to the position input portion 140, a hardware button, an external connection terminal, and the like may be provided on the surface of a housing 101.With such a structure, images can be displayed not only on the plane parallel to the front surface of the housing like in a conventional data processing device but also on the side surface of the housing.", "In particular, display regions are preferably provided along the two or more side surfaces of the housing because the variety of display is further increased.", "A display region provided along the front surface of the data processing device and display regions provided along the side surface thereof may be independently used as display regions to display different images or the like, or two or more of the display regions may display one image or the like.", "For example, a continuous image may be displayed on the display region provided along the front surface of the data processing device and the display region provided along the side surface thereof and the like.", "FIG.", "10A1 is a schematic view illustrating arrangement of a position input portion 140 and the display portion 130 that can be employed in the data processing device 100 of one embodiment of the present invention, and FIG.", "10A2 is a schematic view illustrating arrangement of proximity sensors 142 of the position input portion 140.FIG.", "10B is a cross-sectional view illustrating a cross-sectional structure of the position input portion 140 along a cutting-plane line X9-X10 in FIG.", "10A2.<Example of Structure of Data Processing Device> The data processing device 100 described here includes an input/output unit 120 which supplies positional data L-INF and to which image data VIDEO is supplied and an arithmetic unit 110 to which the positional data L-INF is supplied and supplies the image data VIDEO (see FIG.", "1).", "The input/output unit 120 includes the position input portion 140 which supplies the positional data L-INF and the display portion 130 to which the image data VIDEO is supplied.", "The position input portion 140 is flexible to be bent such that, for example, a first region 140(1), a second region 140(2) facing the first region 140(1), and a third region 140(3) between the first region 140(1) and the second region 140(2) are formed (see FIG.", "2B).", "For another example, the position input portion 140 is flexible to be folded, such that the first region 140(1), the third region 140(3), and a fourth region 140(4) facing the third region 140(3) are formed (see FIG.", "2E).", "For another example, the position input portion 140 is flexible to be folded, such that the third region 140(3), a fifth region 140(5), the fourth region 140(4) facing the third region 140(3) are formed (see FIG.", "3C).", "Note that the surfaces or regions may be provided with the respective position input portions 140.For example, as illustrated in FIGS.", "4C, 4D, and 4E, position input portions 140(A), 140(B), 140(C), 140(D), and 140(E) may be provided in the respective regions.", "Alternatively, a structure may be employed in which some of the position input portions 140(A), 140(B), 140(C), 140(D), and 140(E) are not provided as illustrated in FIG.", "4F.", "As illustrated in FIGS.", "4G and 4H, the position input portion may be provided around the entire inside surface of a housing.", "Note that the second region 140(2) may face the first region 140(1) with or without an inclination.", "Note that the fourth region 140(4) may face the third region 140(3) with or without an inclination.", "The display portion 130 is supplied with the image data VIDEO and is provided to overlap with at least part of the first region 140(1), the second region 140(2), the third region 140(3), the fourth region 140(4), or the fifth region 140(5).", "The arithmetic unit 110 includes an arithmetic portion 111 and a memory portion 112 that stores a program to be executed by the arithmetic portion 111 (see FIG.", "1).", "The data processing device 100 includes the flexible position input portion 140 sensing proximity or touch of an object.", "The position input portion 140 can be bent such that the first region 140(1), the second region 140(2) facing the first region 140(1), and the third region 140(3) positioned between the first region 140(1) and the second region 140(2) and overlapping with the display portion 130 are formed, for example.", "With this structure, whether or not a palm or a finger is proximate to or touches the first region 140(1), the second region 140(2), or the like can be determined.", "As a result, a human interface with high operability can be provided.", "Furthermore, a novel data processing device with high operability can be provided.", "Individual components included in the data processing device 100 are described below (see FIG.", "1).", "Note that these units can not be clearly distinguished and one unit also serves as another unit or include part of another unit in some cases.", "For example, a touch panel in which a touch sensor overlaps with a display portion is provided over the position input portion 140 as well as over the display portion 130.<<Input/Output Device>> The input/output unit 120 includes the position input portion 140 and the display portion 130.An input/output portion 145, a sensor portion 150, a communication portion 160, and the like may also be included.", "The input/output unit 120 is supplied with data and can supply data (see FIG.", "1).", "<<Position Input Portion>> The position input portion 140 supplies the positional data L-INF.", "The user of the data processing device 100 can supply the positional data L-INF to the position input portion 140 by touching the position input portion 140 with his/her finger or palm and thereby supplying a variety of operation instructions to the data processing device 100.For example, an operation instruction including a termination instruction (an instruction to terminate the program) can be supplied (see FIG.", "1).", "The position input portion 140 includes, for example, the first region 140(1), the second region 140(2), and the third region 140(3) between the first region 140(1) and the second region 140(2) (see FIG.", "10A1).", "In each of the first region 140(1), the second region 140(2), and the third region 140(3), the proximity sensors 142 are arranged in matrix (see FIG.", "10A2).", "The position input portion 140 includes, for example, a flexible substrate 141 and the proximity sensors 142 over the flexible substrate 141 (see FIG.", "10B).", "The position input portion 140 can be bent such that the second region 140(2) and the first region 140(1) face each other (see FIG.", "2B).", "The third region 140(3) of the position input portion 140 overlaps with the display portion 130 (see FIGS.", "2B and 10A1).", "Note that when the third region 140(3) is positioned closer to the user than the display portion 130 is, the third region 140(3) has a light-transmitting property.", "The distance between the second region and the first region of the position input portion 140 in a bent state is one that allows the user of the data processing device 100 to hold it in his/her hand (see FIG.", "14A1).", "The distance is, for example, 17 cm or shorter, preferably 9 cm or shorter, further preferably 7 cm or shorter.", "When the distance is short, the thumb of the holding hand can be used to input the positional data to a wide range of the third region 140(3).", "Thus, the user of the data processing device 100 can use the data processing device 100, holding it with the thumb joint portion (the vicinity of the thenar) being proximate to or touching one of the first region 140(1) and the second region 140(2), and a finger(s) other than the thumb being proximate to or touching the other.", "The shape of the thumb joint portion (the vicinity of the thenar) being proximate to or touching one of the first region 140(1) and the second region 140(2) is different from the shape(s) of the finger(s) other than the thumb being proximate to or touching the other region; therefore, the first region 140(1) supplies positional data different from that supplied by the second region 140(2).", "Specifically, the shape of the thumb joint portion (the vicinity of the thenar) being proximate to or touching one region is larger than the shape(s) of the finger(s) other than the thumb being proximate to or touching the other region or is continuous (not divided), for example.", "The proximity sensor 142 is a sensor that can sense proximity or touch of an object (e.g., a finger or a palm), and a capacitor or an imaging element can be used as the proximity sensor.", "Note that a substrate provided with capacitors arranged in matrix can be referred to as a capacitive touch sensor, and a substrate provided with an imaging element can be referred to as an optical touch sensor.", "For the flexible substrate 141, a resin thin enough to be flexible can be used.", "Examples of the resin include polyester, polyolefin, polyamide, polyimide, aramid, epoxy, polycarbonate, and an acrylic resin.", "As a normal substrate not having flexibility, a glass substrate, a quartz substrate, a semiconductor substrate, or the like can be used.", "Specific examples of a structure that can be employed in the position input portion 140 are described in Embodiments 6 and 7.<<Display Portion>> The display portion 130 and at least the third region 140(3) of the position input portion 140 overlap with each other.", "Not only the third region 140(3) but also the first region 140(1) and/or the second region 140(2) may overlap with the display portion 130.There is no particular limitation on the display portion 130 as long as the display portion 130 can display the supplied image data VIDEO.", "An operation instruction associated with a portion of the display portion 130 with which the first region 140(1) and/or the second region 140(2) overlap(s) may be different from an operation instruction associated with a portion of the display portion 130 with which the third region 140(3) overlaps.", "The user can thus see, from display on the display portion, what operation instruction is associated with the portion with which the first region 140(1) and/or the second region 140(2) overlap(s).", "Consequently, a variety of operation instructions can be associated.", "Moreover, false input of an operation instruction can be reduced.", "Specific examples of a structure that can be employed in the display portion 130 are described in Embodiments 6 and 7.<<Arithmetic Unit>> The arithmetic unit 110 includes the arithmetic portion 111, the memory portion 112, an input/output interface 115, and a transmission path 114 (see FIG.", "1).", "The arithmetic unit 110 is supplied with the positional data L-INF and supplies the image data VIDEO.", "For example, the arithmetic unit 110 supplies the image data VIDEO including an image used for operation of the data processing device 100, and the input/output unit 120 is supplied with the image data VIDEO including the image used for operation.", "The display portion 130 displays the image used for operation.", "By touching a portion of the third region 140(3) overlapping with the display portion 130 in which an image used for operation is displayed with his/her finger, the user can supply the positional data L-INF for selecting the image.", "<<Arithmetic Portion>> The arithmetic portion 111 executes the program stored in the memory portion 112.For example, in response to supply of the positional data L-INF that is associated with a position in which an image used for operation is displayed, the arithmetic portion 111 executes a program associated with the image.", "<<Memory Portion>> The memory portion 112 stores the program to be executed by the arithmetic portion 111.Note that examples of a program to be executed by the arithmetic unit 110 are described in other embodiments.", "<<Input/Output Interface and Transmission Path>> The input/output interface 115 supplies data and is supplied with data.", "The transmission path 114 can supply data, and the arithmetic portion 111, the memory portion 112, and the input/output interface 115 are supplied with data.", "In addition, the arithmetic portion 111, the memory portion 112, and the input/output interface 115 can supply data and the transmission path 114 is supplied with data.", "The data processing device 100 includes the arithmetic unit 110, the input/output unit 120, and the housing 101 (see FIG.", "1 and FIG.", "2B).", "<<Sensor Portion>> The sensor portion 150 senses the states of the data processing device 100 and the circumstances and supplies sensing data SENS (see FIG.", "1).", "Note that the sensor portion 150 senses, for example, acceleration, a direction, pressure, a global positioning system (GPS) signal, temperature, humidity, or the like and may supply data thereon.", "<<Communication Unit>> The communication portion 160 supplies data COM supplied by the arithmetic unit 110 to a device or a communication network outside the data processing device 100.Furthermore, the communication portion 160 acquires the data COM from the device or communication network outside the data processing device 100 and supplies the data COM.", "The data COM can include a variety of instructions and the like.", "For example, the data COM can include a display instruction to make the arithmetic portion 111 generate or delete the image data VIDEO.", "A communication unit for connection to the external device or external communication network, e.g., a hub, a router, or a modem, can be used for the communication portion 160.Note that the connection method is not limited to a method using a wire, and a wireless method (e.g., radio wave or infrared rays) may be used.", "<<Input/Output Unit>> As the input/output portion 145, for example, a camera, a microphone, a read-only external memory portion, an external memory portion, a scanner, a speaker, or a printer can be used (see FIG.", "1).", "Specifically, as a camera, a digital camera, digital video camera, or the like can be used.", "As an external memory portion, a hard disk, a removable memory, or the like can be used.", "As a read-only external memory portion, a CD-ROM, a DVD-ROM, or the like can be used.", "<<Housing>> The housing 101 protects the arithmetic unit 110 and the like from external stress.", "The housing 101 can be formed using metal, plastic, glass, ceramics, or the like.", "This embodiment can be combined with any of the other embodiments in this specification as appropriate.", "Embodiment 2 In this embodiment, the structure of the data processing device of one embodiment of the present invention will be described with reference to drawings.", "FIG.", "11 shows a block diagram of a structure of a data processing device 100B of one embodiment of the present invention.", "FIGS.", "12A to 12C are schematic views illustrating the external appearance of the data processing device 100B.", "FIG.", "12A is the schematic view illustrating the external appearance of the data processing device 100B in an unfolded state, FIG.", "12B is the schematic view illustrating the external appearance of the data processing device 100B in a bent state, and FIG.", "12C is the schematic view illustrating the external appearance of the data processing device 100B in a folded state.", "FIGS.", "13A to 13E are schematic views illustrating the structures of the data processing device 100B.", "FIGS.", "13A to 13D illustrate the structure in an unfolded state and FIG.", "13E illustrates the structure in a folded state.", "FIG.", "13A is a top view of the data processing device 100B, FIG.", "13B is a bottom view of the data processing device 100B, and FIG.", "13C is a side view of the data processing device 100B.", "FIG.", "13D is a cross-sectional view illustrating a cross section of the data processing device 100B taken along a cutting-plane line Y1-Y2 in FIG.", "13A.", "FIG.", "13E is a side view of the data processing device 100B in the folded state.", "<Example of Structure of Data Processing Device> The data processing device 100B described here includes an input/output unit 120B which supplies the positional data L-INF and the sensing data SENS including folding data and to which the image data VIDEO is supplied and the arithmetic unit 110 to which the positional data L-INF and the sensing data SENS including the folding data are supplied and which supplies the image data VIDEO (see FIG.", "11).", "The input/output unit 120B includes a position input portion 140B, the display portion 130, and the sensor portion 150.The position input portion 140B is flexible to be unfolded or folded such that the first region 140B(1), the second region 140B(2) facing the first region 140B(1), and the third region 140B(3) between the first region 140B(1) and the second region 140B(2) are formed (see FIGS.", "12A to 12C and FIGS.", "13A to 13E).", "The sensor portion 150 includes a folding sensor 151 capable of sensing a folded state of the position input portion 140B and supplying the sensing data SENS including the folding data.", "The display portion 130 is supplied with the image data VIDEO and is positioned so that the display portion 130 and the third region 140B(3) overlap with each other.", "The arithmetic unit 110 includes the arithmetic portion 111 and the memory portion 112 that stores the program to be executed by the arithmetic portion 111 (see FIG.", "13D).", "The data processing device 100B described here includes the flexible position input portion 140B sensing a palm or a finger that is proximate to the first region 140B(1), the second region 140B(2) facing the first region 140B(1) in the folded state, and the third region 140B(3) positioned between the first region 140B(1) and the second region 140B(2) and overlapping with the display portion 130; and the sensor portion 150 including the folding sensor 151 capable of determining whether the flexible position input portion 140B is in a folded state or an unfolded state (see FIG.", "11 and FIGS.", "13A to 13E).", "With this structure, whether or not a palm or a finger is proximate to the first region 140B(1) or the second region 140B(2) can be determined.", "As a result, a human interface with high operability can be provided.", "Furthermore, a novel data processing device with high operability can be provided.", "Individual components included in the data processing device 100B are described below.", "Note that these units can not be clearly distinguished and one unit also serves as another unit or include part of another unit in some cases.", "For example, a touch panel in which a touch sensor overlaps with a display portion is provided over the position input portion 140B as well as over the display portion 130.The data processing device 100B is different from the data processing device described in Embodiment 1 in that the position input portion 140B is flexible to be in an unfolded state or a folded state and that the sensor portion 150 in the input/output unit 120B includes the folding sensor 151.Different structures will be described in detail below, and the above description is referred to for the other similar structures.", "<<Input/Output Device>> The input/output unit 120B includes the position input portion 140B, the display portion 130, and the sensor portion 150 including the folding sensor 151.The input/output portion 145, a sign 159, the communication portion 160, and the like may also be included.", "The input/output unit 120B is supplied with data and can supply data (FIG.", "11).", "<<Structure Enabling Folding and Unfolding of Data Processing Device>> The data processing device 100B has a housing in which a high flexibility portion E1 and a low flexibility portion E2 are alternately provided.", "In other words, in the housing of the data processing device 100B, the high flexibility portion E1 and the low flexibility portion E2 are strip-like portions (form stripes) (see FIGS.", "13A and 13B).", "The above-described structure allows the data processing device 100B to be folded (see FIGS.", "12A to 12C).", "The data processing device 100B in a folded state is highly portable.", "It is possible to fold the data processing device 100B such that part of the third region 140B(3) of the position input portion 140B is on the outer side and use only part of the third region 140B(3) (see FIG.", "12C).", "The high flexibility portion E1 and the low flexibility portion E2 can have a shape both sides of which are parallel to each other, a triangular shape, a trapezoidal shape, a fan shape, or the like.", "The user of the data processing device 100B folded to a size that allows the data processing device to be held in one hand can operate part of the third region 140B(3) of the position input portion with the thumb of his/her hand supporting the data processing device and input positional data.", "In the above manner, the data processing device that can be operated with one hand can be provided (see FIG.", "15A).", "Note that in a folded state such that parts of the position input portion 140 are on the inner side, the user cannot operate part of the third region 140B(3) (see FIG.", "12C).", "Thus, it is possible to stop driving of part of the third region 140B(3) of the position input portion in a folded state.", "In that case, the data processing device 100B can have reduced power consumption with the position input portion in a folded state.", "The position input portion 140B in an unfolded state is seamless and has a wide operation region.", "The display portion 130 and the third region 140B(3) of the position input portion overlap with each other (see FIG.", "13D).", "The position input portion 140B is interposed between a connecting member 13a and a connecting member 13b.", "The connecting member 13a and the connecting member 13b are interposed between a supporting member 15a and a supporting member 15b (see FIG.", "13C).", "The display portion 130, the position input portion 140B, the connecting member 13a, the connecting member 13b, the supporting member 15a, and the supporting member 15b are fixed by any of a variety of methods; for example, it is possible to use an adhesive, a screw, structures that can be fit with each other, or the like.", "<<High Flexibility Portion>> The high flexibility portion E1 is bendable and functions as a hinge.", "The high flexibility portion E1 includes the connecting member 13a and the connecting member 13b overlapping with each other (see FIGS.", "13A to 13C).", "<<Low Flexibility Portion>> The low flexibility portion E2 includes at least one of the supporting member 15a and the supporting member 15b.", "For example, the low flexibility portion E2 includes the supporting member 15a and the supporting member 15b overlapping with each other.", "Note that when only the supporting member 15b is included, the weight and thickness of the low flexibility portion E2 can be reduced.", "<<Connecting Member>> The connecting member 13a and the connecting member 13b are flexible.", "For example, flexible plastic, metal, alloy and/or rubber can be used as the connecting member 13a and the connecting member 13b.", "Specifically, silicone rubber can be used as the connecting member 13a and the connecting member 13b.", "<<Supporting Member>> Any one of the supporting member 15a and the supporting member 15b has lower flexibility than the connecting member 13a and the connecting member 13b.", "The supporting member 15a or the supporting member 15b can increase the mechanical strength of the position input portion 140B and protect the position input portion 140B from breakage.", "For example, plastic, metal, alloy, rubber, or the like can be used as the supporting member 15a or the supporting member 15b.", "The connecting member 13a, the connecting member 13b, the supporting member 15a, or the supporting member 15b formed using plastic, rubber, or the like can be lightweight or break-resistant.", "Specifically, engineering plastic or silicone rubber can be used.", "Stainless steel, aluminum, magnesium alloy, or the like can also be used for the supporting member 15a and the supporting member 15b.", "<<Position Input Portion>> The position input portion 140B can be in an unfolded state or a folded state (see FIGS.", "12A to 12C).", "The third region 140B(3) in an unfolded state is positioned on a top surface of the data processing device 100B (see FIG.", "13C), and the third region 140B(3) in a folded state is positioned on the top surface and a side surface of the data processing device 100B (see FIG.", "13E).", "The usable area of the unfolded position input portion 140B is larger than that of the folded position input portion 140B.", "When the position input portion 140B is folded, an operation instruction that is different from an operation instruction associated with a portion of the third region 140B(3) on the top surface of the data processing device 100B can be associated with a portion of the third region 140B(3) on the side surface of the data processing device 100B.", "Note that an operation instruction that is different from an operation instruction associated with the second region 140B(2) may be associated with the portion of the third region 140B(3) on the side surface of the data processing device 100B.", "In this manner, a complex operation instruction can be given with the use of the position input portion 140B.", "The position input portion 140B supplies the positional data L-INF (see FIG.", "11).", "The position input portion 140B is provided between the supporting member 15a and the supporting member 15b.", "The position input portion 140B may be interposed between the connecting member 13a and the connecting member 13b.", "The position input portion 140B includes the first region 140B(1), the second region 140B(2), and the third region 140B(3) between the first region 140B(1) and the second region 140B(2) (see FIG.", "13D).", "The position input portion 140B includes a flexible substrate and proximity sensors over the flexible substrate.", "In each of the first region 140B(1), the second region 140B(2), and the third region 140B(3), the proximity sensors are arranged in matrix.", "Specific examples of a structure that can be employed in the position input portion 140B are described in Embodiments 6 and 7.<<Sensor Portion and Sign>> The data processing device 100B includes the sensor portion 150.The sensor portion 150 includes the folding sensor 151 (see FIG.", "11).", "The folding sensor 151 and the sign 159 are positioned in the data processing device 100B so that a folded state of the position input portion 140B can be sensed (FIGS.", "12A and 12B and FIGS.", "13A, 13C, and 13E).", "In a state where the position input portion 140B is unfolded, the sign 159 is positioned away from the folding sensor 151 (see FIG.", "12A and FIGS.", "13A and 13C).", "In a state where the position input portion 140B is bent at the connecting members 13a, the sign 159 is close to the folding sensor 151 (see FIG.", "12B).", "In a state where the position input portion 140B is folded at the connecting members 13a, the sign 159 faces the folding sensor 151 (see FIG.", "13E).", "The sensor portion 150 senses the sign 159 to determine that the position input portion 140B is in a folded state and supplies the sensing data SENS including folding data.", "<<Display Portion>> The display portion 130 and at least part of the third region 140(3) of the position input portion 140 overlap with each other.", "The display portion 130 can display the supplied image data VIDEO.", "Particularly when flexible, the display portion 130 can be unfolded or folded with the position input portion 140 overlapping with the display portion 130.Thus, seamless display with excellent browsability can be performed by the display portion 130.Specific examples of a structure that can be employed in the flexible display portion 130 are described in Embodiments 6 and 7.<<Arithmetic Unit>> The arithmetic unit 110 includes the arithmetic portion 111, the memory portion 112, an input/output interface 115, and a transmission path 114 (see FIG.", "11).", "This embodiment can be combined with any of the other embodiments in this specification as appropriate.", "Embodiment 3 In this embodiment, a structure of a data processing device of one embodiment of the present invention will be described with reference to drawings.", "FIGS.", "14A1, 14A2, 14B1, and 14B2 illustrate a state where the data processing device 100 of one embodiment of the present invention is held by a user.", "FIG.", "14A1 illustrates the external appearance of the data processing device 100 held by a user, and FIG.", "14A2 illustrates the ranges of a palm and fingers holding the data processing device 100 that are sensed by the proximity sensor in the position input portion 140 illustrated in FIG.", "14A1.Note that the case where separate position input portions 140(A), 140(B), and 140(C) are used is illustrated in FIG.", "17A.", "The description for the case of FIG.", "17A can apply to the case of FIG.", "14A2.FIG.", "14B1 is a schematic view where solid lines denote results of edge sensing processing of first positional data L-INF(1) sensed by the first region 140(1) of the position input portion 140 and second positional data L-INF(2) sensed by the second region 140(2).", "FIG.", "14B2 is a schematic view where hatching patterns denote results of labelling processing of the first positional data L-INF(1) and the second positional data L-INF(2).", "FIGS.", "16A and 16B are flow charts showing the programs to be executed by the arithmetic portion 111 of the data processing device of one embodiment of the present invention.", "<Example of Structure of Data Processing Device> The data processing device described here is the data processing device 100 in Embodiment 1 in which the first region 140(1) supplies the first positional data L-INF(1) and the second region 140(2) supplies the second positional data L-INF(2) (see FIG.", "14A2); and the image data VIDEO to be displayed on the display portion 130 with which the third region 140(3) overlaps is generated by the arithmetic portion 111 in accordance with results of a comparison between the first positional data L-INF(1) and the second positional data L-INF(2) (see FIG.", "1, FIGS.", "2A to 2E, FIGS.", "10A1, 10A2, 10B and FIGS.", "14A1, 14A2, 14B1, and 14B2).", "Individual components included in the data processing device 100 are described below.", "Note that these units can not be clearly distinguished and one unit also serves as another unit or include part of another unit in some cases.", "For example, a touch panel in which a touch sensor overlaps with a display portion is provided over the position input portion 140 as well as over the display portion 130.The data processing device 100 is different from the data processing device described in Embodiment 1 in that the first region of the position input portion 140 supplies the first positional data and the second region of the position input portion 140 supplies the second positional data, and that an image to be displayed on the display portion 130 is generated in accordance with results of a comparison between the first positional data and the second positional data.", "Different structures will be described in detail below, and the above description is referred to for the other similar structures.", "<<Position Input Portion>> The position input portion 140 is flexible to be bent such that the first region 140(1), the second region 140(2) facing the first region 140(1), and the third region 140(3) provided between the first region 140(1) and the second region 140(2) and overlapping with the display portion 130 are formed (see FIG.", "2B).", "FIG.", "14A1 illustrates the data processing device 100 held by a user.", "In FIG.", "14A2, the ranges of a palm and fingers holding the data processing device 100 that are sensed by the proximity sensor in the position input portion 140 are illustrated together with the position input portion 140 in the unfolded state.", "The first region 140(1) and the second region 140(2) of the data processing device 100 held by a user sense part of the user's palm and part of the user's fingers.", "For example, the first region 140(1) supplies the first positional data L-INF(1) including data on contact positions of part of the index finger, the middle finger, and the ring finger, and the second region 140(2) supplies the second positional data L-INF(2) including data on a contact position of the thumb joint portion (the vicinity of the thenar).", "Note that the third region 140(3) supplies data on a contact position of the thumb.", "<<Display Portion>> The display portion 130 and the third region 140(3) overlap with each other (see FIGS.", "14A1 and 14A2).", "The display portion 130 is supplied with the image data VIDEO and displays the image data VIDEO.", "For example, the image data VIDEO including an image used for operation of the data processing device 100 can be displayed.", "A user of the data processing device 100 can input positional data for selecting the image, by making his/her thumb touch the third region 140(3) overlapping with the image.", "For example, a keyboard 131, icons, and the like are displayed on the right side as illustrated in FIG.", "17B when operation is performed with the right hand.", "The keyboard 131, icons, and the like are displayed on the left side as illustrated in FIG.", "17C when operation is performed with the left hand.", "In this way, operation with fingers is facilitated.", "Note that a displayed screen may be changed in response to sensing of inclination of the data processing device 100 by the sensor portion 150 that senses acceleration.", "For example, the left end of the data processing device 100 held in the left hand as illustrated in FIG.", "18A is positioned higher than the right end as illustrated in FIG.", "18C when seen in the direction denoted by an arrow 152.Here, in response to sensing of this inclination, a screen for the left hand is displayed as illustrated in FIG.", "17C and the keyboard 131 for the left hand is operated.", "In a similar manner, the right end of the data processing device 100 held in the right hand as illustrated in FIG.", "18B is positioned higher than the left end as illustrated in FIG.", "18D when seen in the direction denoted by the arrow 152.Here, in response to sensing of this inclination, a screen for the right hand is displayed as illustrated in FIG.", "17B and the keyboard 131 for the right hand is operated.", "The display positions of a keyboard, icons, and the like may be controlled in this manner.", "Note that the method for sensing inclination of the data processing device 100 and the method illustrated in FIGS.", "14A1, 14A2, 14B1, and 14B2 may be combined to control the display positions.", "Alternatively, without sensing of information, the screen may be switched between an operation screen for the right hand and an operation screen for the left hand by the user of the data processing device 100.<<Arithmetic Portion>> The arithmetic portion 111 is supplied with the first positional data L-INF(1) and the second positional data L-INF(2) and generates the image data VIDEO to be displayed on the display portion 130 in accordance with results of a comparison between the first positional data L-INF(1) and the second positional data L-INF(2).", "<Example of Structure of Data Processing Device> The data processing device described here is different from the data processing device described in Embodiment 1 or that described above in that the memory portion stores a program in accordance with which the arithmetic portion 111 executes the following seven steps (see FIG.", "16A).", "Different processes will be described in detail below, and the above description is referred to for the other similar processes.", "<<Example of Program>> In a first step, the length of a first line segment is determined using the first positional data L-INF(1) supplied by the first region 140(1) (see 51 in FIG.", "16A).", "In a second step, the length of a second line segment is determined using the second positional data L-INF(2) supplied by the second region 140(2) (see S2 in FIG.", "16A).", "In a third step, the length of the first line segment and the length of the second line segment are compared with the predetermined length.", "The program proceeds to a fourth step when only one of the lengths of the first and second line segments is longer than the predetermined length.", "The program proceeds to the first step in other cases (see S3 in FIG.", "16A).", "Note that it is preferable that the predetermined length be longer than or equal to 2 cm and shorter than or equal to 15 cm, and it is particularly preferable that the predetermined length be longer than or equal to 5 cm and shorter than or equal to 10 cm.", "In a fourth step, the coordinates of the midpoint of the line segment longer than the predetermined length are determined (see S4 in FIG.", "16A).", "In a fifth step, whether “tap”, “flick”, or the like is performed in a region in which the coordinates of the midpoint is not determined is checked in the first region 140(1) or the second region 140(2) (see S5 in FIG.", "16A).", "In a sixth step, the image data VIDEO to be displayed on the display portion 130 which overlaps with the third region 140(3) is generated based on the coordinates of the midpoint and whether the operation of “tap” or “flick” has been performed confirmed in the fifth step (see S6 in FIG.", "16A).", "In a seventh step, the program is terminated (see S7 in FIG.", "16A).", "The data processing device 100 described here includes the flexible position input portion 140 capable of sensing proximity or touch of an object and supplying the positional data L-INF, and the arithmetic portion 111.The flexible position input portion 140 can be bent such that the first region 140(1), the second region 140(2) facing the first region 140(1), and the third region 140(3) positioned between the first region 140(1) and the second region 140(2) and overlapping with the display portion 130 are formed.", "The arithmetic portion 111 can compare the first positional data L-INF(1) supplied by the first region 140(1) with the second positional data L-INF(2) supplied by the second region 140(2) and generate the image data VIDEO to be displayed on the display portion 130.With this structure, whether a palm or a finger is proximate to or touches the first region 140(1) or the second region 140(2) can be determined, furthermore, whether the data processing device is operated with one hand or whether it is operated with both hands can be determined, and the image data VIDEO including an image (e.g., an image used for operation) positioned for easy operation can be generated.", "As a result, a human interface with high operability can be provided.", "Furthermore, a novel data processing device with high operability can be provided.", "Note that a step in which the display portion 130 displays the predetermined image data VIDEO (also referred to as initial image) may be included before the first step.", "In that case, the predetermined image data VIDEO can be displayed when both the length of the first line segment and that of the second line segment are longer or shorter than the predetermined length.", "Individual processes executed by the arithmetic portion with the use of the program are described below.", "Note that these processes cannot be clearly distinguished and one process also serves as another process or include part of another process in some cases.", "<<Method for Determining Midpoint of Line Segment>> Hereinafter, a method for determining the length of the first line segment and the length of the second line segment using the first positional data L-INF(1) and the second positional data L-INF(2), respectively, is described.", "A method for determining the midpoint of a line segment is also described.", "Specifically, an edge sensing method for determining the length of a line segment is described.", "Note that although description is given of an example in which an imaging element is used as the proximity sensor, a capacitor or the like may be used as the proximity sensor.", "Assume that a value acquired by an imaging pixel with coordinates (x, y) is f(x, y).", "It is preferable that a value obtained by subtracting a background value from a value sensed by the imaging pixel be used as f(x, y) because noise can be removed.", "<<Method for Extracting Edge (Contour)>> Formula 1 below expresses the sum Δ(x, y) of differences between a value sensed by the imaging pixel with the coordinates (x, y) and values sensed by imaging pixels with coordinates (x−1, y), coordinates (x+1, y), coordinates (x, y−1), and coordinates (x, y+1), which are adjacent to the coordinates (x, y).", "Δ(x,y)=4·f(x,y)−{f(x,y−1)+f(x,y+1)+f(x−1,y)+f(x+1,y)} [Formula 1] FIG.", "14A2 shows values sensed by the imaging pixels in the first region 140(1) and the second region 140(2).", "FIG.", "14B1 shows calculation results of Δ(x, y).", "When Δ(x, y) is used in the above manner, an edge (contour) of a finger or a palm that is proximate to or touches the first region 140(1) and the second region 140(2) can be extracted to the first region 140(1) and the second region 140(2).", "<<Method for Determining Length of Line Segment>> The coordinates of intersection between the contour extracted to the first region 140(1) and a predetermined line segment W1 are determined, and the predetermined line segment W1 is cut at the point of intersection to be divided into a plurality of line segments.", "The line segment having the longest length among the plurality of line segments is the first line segment.", "Note that the length of the first line segment is length L1 (see FIG.", "14-B1).", "The coordinates of intersection between the contour extracted to the second region 140(2) and a predetermined line segment W2 are determined, and the predetermined line segment W2 is cut at the point of intersection to be divided into a plurality of line segments.", "The line segment having the longest length among the plurality of line segments is the second line segment.", "Note that the length of the second line segment is length L2.<<Method for Determining Midpoint>> The length of the first line segment L1 and the length of the second line segment L2 are compared with each other, the longer one is selected, and the coordinates of a midpoint M is calculated.", "In this embodiment, the length L2 is longer than the length L1; thus, the coordinates of the midpoint M of the second line segment are determined.", "<<Image Data Generated in Accordance with Coordinates of Midpoint>> The coordinates of the midpoint M can be associated with the position of the thumb joint portion (the vicinity of the thenar), the movable range of the thumb, or the like.", "In this manner, image data that facilitates operation of the data processing device 100 can be generated in accordance with the coordinates of the midpoint M. For example, it is possible to generate the image data VIDEO that includes an image used for operation positioned in the display portion 130 with which the third region 140(3) in the movable range of the thumb overlaps.", "Specifically, images used for operation (denoted by circles) can be positioned on a circular arc whose center is in the vicinity of the midpoint M (see FIG.", "14A1).", "Among images used for operation, images that are used frequently may be positioned on a circular arc and images that are used less frequently may be positioned inside or outside the circular arc.", "As a result, a human interface with high operability can be provided.", "Furthermore, a novel data processing device with high operability can be provided.", "In the case where an operations such as “tap” or “flick” are detected in the region in which the midpoint M is not calculated in the first region 140(1) and the second region 140(2), it can be determined that a user operates the data processing device 100 with both hands, and a predetermined processing such as the display of image data VIDEO which is different from the above can be executed.", "For example, when the operations such as “tap” or “flick” are detected in the second region 140(2) at the same time as the midpoint M is calculated in the first region 140(1), it can be determined that a user operates the data processing device 100 with both hands, and a predetermined image can be displayed on the display portion 130.In the case where the operations such as “tap” or “flick” are detected in the region in which the midpoint M is not calculated in the first region 140(1) and the second region 140(2), the predetermined processing may be performed by determining that the data processing device is not operated by both hands.", "For example, predetermined program execution, display or non-display of images, or turning on or off a power source may be performed.", "<Example of Structure of Data Processing Device> The data processing device described here is different from the data processing device described in Embodiment 1 or that described above in that the memory portion stores a program in accordance with which the arithmetic portion 111 executes the following six steps, in which the area of a first figure and the area of a second figure are used instead of the length of the first line segment and the length of the second line segment (see FIG.", "16B).", "Different processes will be described in detail below, and the above description is referred to for the other similar processes.", "<<Example of Program>> In a first step, the area of the first figure is determined using the first positional data L-INF(1) supplied by the first region 140(1) (T1 in FIG.", "16B).", "In a second step, the area of the second figure is determined using the second positional data L-INF(2) supplied by the second region 140(2) (T2 in FIG.", "16B).", "In a third step, the area of the first figure and the area of the second figure are compared with the predetermined area.", "The program proceeds to a fourth step when only one of the areas of the first and second figures is larger than the predetermined area.", "The program proceeds to the first step in other cases (T3 in FIG.", "16B).", "Note that it is preferable that the predetermined area be larger than or equal to 1 cm2 and smaller than or equal to 8 cm2, and it is particularly preferable that the predetermined area be larger than or equal to 3 cm2 and smaller than or equal to 5 cm2.In a fourth step, the barycentric coordinates of the figure whose area is larger than the predetermined area are determined (T4 in FIG.", "16B).", "In a fifth step, whether “tap”, “flick”, or the like is performed in a region in which barycentric coordinates are not determined in the first region 140(1) and the second region 140(2) is checked (see T5 in FIG.", "16A).", "In a sixth step, the image data VIDEO to be displayed on the display portion 130 which overlaps with the third region is generated based on the barycentric coordinates and whether the operation of “tap” or “flick” has been performed confirmed in the fifth step (T6 in FIG.", "16B).", "In a seventh step, the program is terminated (see T7 in FIG.", "16B).", "Individual processes executed by the arithmetic portion with the use of the program are described below.", "Note that these processes cannot be clearly distinguished and one process also serves as another process or include part of another process in some cases.", "<<Method for Determining Center of Area>> Hereinafter, a method for determining the area of the first figure and the area of the second figure using the first positional data L-INF(1) and the second positional data L-INF(2), respectively, is described.", "A method for determining the center of gravity of a figure is also described.", "Specifically, labeling processing for determining the area of a figure is described.", "Note that although description is given of an example in which an imaging element is used as the proximity sensor, a capacitor or the like may be used as the proximity sensor.", "Assume that a value acquired by an imaging pixel with coordinates (x, y) is f(x, y).", "It is preferable that a value obtained by subtracting a background value from a value sensed by the imaging pixel be used as f(x, y) because noise can be removed.", "<<Labelling Processing>> In the case where one imaging pixel and an adjacent imaging pixel in the first region 140(1) and the second region 140(2) each acquire a value f(x, y) exceeding a predetermined threshold value, the region where the region occupied by these imaging pixels is regarded as one figure.", "Note that when f(x, y) can be 256, for example, it is preferable that the predetermined threshold value be greater than or equal to 0 and less than or equal to 150, and it is particularly preferable that the predetermined threshold value be greater than or equal to 0 and less than or equal to 50.The above processing is performed on all of the imaging pixels in the first region 140(1) and the second region 140(2), and imaging of the results is carried out to give the regions in which adjacent imaging pixels each exceeds the predetermined threshold value as shown in FIGS.", "14A2 and 14B2.The figure having the largest area among figures in the first region 140(1) is the first figure.", "The figure having the largest area among figures in the second region 140(2) is the second figure.", "<<Method for Determining Center of Gravity of Figure>> The area of the first figure and that of the second figure are compared, the larger one is selected, and the center of gravity is calculated.", "Coordinates C(X, Y) of the center of gravity can be calculated using Formula (2) below.", "C ( X , Y ) = ( 1 n  ∑ i = 0 n - 1   x i , 1 n  ∑ i = 0 n - 1   y i ) [ Formula   2 ] In Equation (2), (x, y) represents the coordinates of n imaging pixels forming one figure.", "The area of the second figure is larger than that of the first figure; thus, the barycentric coordinates C of the second figure are determined.", "<<Image Data Generated in Accordance with Barycentric Coordinates>> The barycentric coordinates C can be associated with the position of the thumb joint portion (the vicinity of the thenar), the movable range of the thumb, or the like.", "In this manner, image data that facilitates operation of the data processing device 100 can be generated in accordance with the barycentric coordinates C. In the case where an operations such as “tap” or “flick” are detected in the region in which the center of gravity C is not calculated in the first region 140(1) and the second region 140(2), it can be determined that a user operates the data processing device 100 by both hands, and the image data VIDEO which is different from above can be displayed.", "In the case where an operations such as “tap” or “flick” are detected in the region in which the center of gravity C is not calculated in the first region 140 (1) and the second region 140 (2), operations other than the display of the image data VIDEO may be performed.", "For example, execution of a predetermined program, display or non-display of images or turning on or off a power source may be performed.", "In the case where the position input portion 140 is provided on the front surface and the back surface of the data processing device 100, the position input portion 140 of the front surface and the back surface are tapped at the same time, whereby execution of the predetermined program, display or non-display of images, or turning on or off a power source may be performed, for example (see FIG.", "19A).", "In addition, portions of the position input portion 140 of the front surface and the back surface are “flicked” at the same time, whereby execution of the predetermined program, display or non-display of images, turning on or off a power source may be performed, for example (see FIG.", "19B).", "Therefore, unexpected malfunctions can be prevented.", "This embodiment can be combined with any of the other embodiments in this specification as appropriate.", "Embodiment 4 In this embodiment, a structure of a data processing device of one embodiment of the present invention will be described with reference to drawings.", "FIGS.", "15A and 15B illustrate a state where the data processing device 100B of one embodiment of the present invention is held by a user.", "FIG.", "15A illustrates the data processing device 100B in a folded state held by a user, and FIG.", "15B illustrates the ranges of a palm and fingers sensed by the data processing device 100B in the state illustrated in FIG.", "15A.", "Note that the ranges of the palm and fingers are illustrated together with the unfolded position input portion 140B.", "FIG.", "20 is a flow chart showing the program to be executed by the arithmetic portion 111 of the data processing device 100B of one embodiment of the present invention.", "FIGS.", "21A to 21C illustrate an example of an image displayed on the display portion 130 of the data processing device 100B of one embodiment of the present invention.", "FIG.", "22 is a flow chart showing the program to be executed by the arithmetic portion 111 of the data processing device 100B of one embodiment of the present invention.", "<Example of Structure of Data Processing Device> In a data processing device described here, the first region 140B(1) of the position input portion 140B supplies the first positional data L-INF(1), and the second region 140B(2) supplies the second positional data L-INF(2) (see FIG.", "15B).", "The sensor portion 150 supplies the sensing data SENS including folding data; and the image data VIDEO to be displayed on the display portion 130 is generated by the arithmetic portion 111 in accordance with the sensing data SENS including the folding data and results of a comparison between the first positional data L-INF(1) and the second positional data L-INF(2) (see FIG.", "11, FIGS.", "12A to 12C, and FIGS.", "15A and 15B).", "Individual components included in the data processing device 100B are described below.", "Note that these units can not be clearly distinguished and one unit also serves as another unit or include part of another unit in some cases.", "For example, a touch panel in which a touch sensor overlaps with a display portion is provided in the position input portion 140B as well as in the display portion 130.The data processing device 100B is different from the data processing device described in Embodiment 2 in that the first region 140B(1) of the position input portion 140B supplies the first positional data and the second region 140B(2) of the position input portion 140B supplies the second positional data, and that an image to be displayed on the display portion 130 is generated in accordance with results of a comparison between the first positional data and the second positional data.", "Different structures will be described in detail below, and the above description is referred to for the other similar structures.", "<<Position Input Portion>> The position input portion 140B is flexible to unfolded or folded such that the first region 140B(1), the second region 140B(2) facing the first region 140B(1), and the third region 140B(3) provided between the first region 140B(1) and the second region 140B(2) and overlapping with the display portion 130B are formed (see FIGS.", "12A to 12C).", "The first region 140B(1) and the second region 140B(2) which the user's palm and the user's fingers are proximate to or touch sense part of the user's palm and part of the user's fingers.", "For example, the first region 140B(1) supplies the first positional data L-INF(1) including data on contact positions of part of the index finger, the middle finger, and the ring finger, and the second region 140B(2) supplies the second positional data L-INF(2) including data on a contact position of the thumb joint portion (the vicinity of the thenar).", "Note that the third region 140B(3) supplies data on a contact position of the thumb.", "<<Display Portion>> The display portion 130 and the third region 140B(3) overlap with each other (see FIGS.", "15A and 15B).", "The display portion 130 is supplied with the image data VIDEO and can display an image used for operation of the data processing device 100B, for example.", "A user of the data processing device 100B can input positional data for selecting the image, by making his/her thumb touch the third region 140B(3) overlapping with the image.", "<<Arithmetic Portion>> The arithmetic portion 111 is supplied with the first positional data L-INF(1) and the second positional data L-INF(2) and generates the image data VIDEO to be displayed on the display portion 130 in accordance with results of a comparison between the first positional data L-INF(1) and the second positional data L-INF(2).", "<Example of Structure of Data Processing Device> The data processing device described here is different from the data processing device described in Embodiment 2 or that described above in that the memory portion stores a program in accordance with which the arithmetic portion 111 executes the following nine steps (see FIG.", "20).", "Different processes will be described in detail below, and the above description is referred to for the other similar processes.", "<<Example of Program>> In a first step, the length of the first line segment is determined using the first positional data supplied by the first region (U1 in FIG.", "20).", "In a second step, the length of the second line segment is determined using the second positional data supplied by the second region (U2 in FIG.", "20).", "In a third step, the length of the first line segment and the length of the second line segment are compared with the predetermined length.", "The program proceeds to a fourth step when only one of the lengths of the first and second line segments is longer than the predetermined length.", "The program proceeds to the first step in other cases (U3 in FIG.", "20).", "Note that it is preferable that the predetermined length be longer than or equal to 2 cm and shorter than or equal to 15 cm, and it is particularly preferable that the predetermined length be longer than or equal to 5 cm and shorter than or equal to 10 cm.", "In the fourth step, the coordinates of the midpoint of the line segment longer than the predetermined length are determined (U4 in FIG.", "20).", "In a fifth step, whether or not the operation such as “tap” or “flick” is performed in a region in which the coordinates of the midpoint are not determined in the first region 140(1) and the second region 140(2) is checked (see U5 in FIG.", "20A).", "In a sixth step, the folding data of the data processing device 100B is acquired.", "The program proceeds to a seventh step when the folding data indicates the folded state (U6 in FIG.", "20).", "In the seventh step, the first image data to be displayed on the display portion 130 with which the third region overlaps is generated in accordance with the coordinates of the midpoint and whether the operation of “tap” or “flick” has been performed which is confirmed in the fifth step (U7 in FIG.", "20).", "In the sixth step, the folding data of the data processing device 100B is acquired.", "The program proceeds to an eighth step when the folding data indicates the folded state (U5 in FIG.", "20).", "In the eighth step, the second image data to be displayed on the display portion with which the third region overlaps is generated in accordance with the coordinates of the midpoint and whether the operation of “tap” or “flick” has been performed which is confirmed in the fifth step (U8 in FIG.", "20).", "In the ninth step, the program is terminated (see U9 in FIG.", "20).", "The data processing device 100B described here includes the flexible position input portion 140B capable of sensing proximity or touch of an object and supplying the positional data L-INF; the sensor portion 150 including the folding sensor 151 that can determine whether the flexible position input portion 140B is in a folded state or an unfolded state; and the arithmetic portion 111 (see FIG.", "11).", "The flexible position input portion 140B can be bent such that the first region 140B(1), the second region 140B(2) facing the first region 140B(1) in the folded state, and the third region 140B(3) positioned between the first region 140B(1) and the second region 140B(2) and overlapping with the display portion 130 are formed.", "The arithmetic portion 111 can compare the first positional data L-INF(1) supplied by the first region 140B(1) with the second positional data L-INF(2) supplied by the second region 140B(2) and generate the image data VIDEO to be displayed on the display portion 130 in accordance with the folded state.", "With this structure, whether or not a palm or a finger is proximate to or touches the first region 140B(1) or the second region 140B(2) can be determined, furthermore, whether data processing device is operated with one hand or with both hands can be determined, and the image data VIDEO including a first image positioned for easy operation in the folded state of the position input portion 140B (e.g., the first image in which an image used for operation is positioned) or a second image positioned for easy operation in the unfolded state of the position input portion 140B can be generated.", "As a result, a human interface with high operability can be provided.", "Furthermore, a novel data processing device with high operability can be provided.", "In the data processing device 100B described here, a step in which the predetermined image data VIDEO is generated by the arithmetic portion 111 and displayed by the display portion 130 may be included before the first step.", "In that case, the predetermined image data VIDEO can be displayed when both the length of the first line segment and that of the second line segment are longer or shorter than the predetermined length in the third step.", "Individual processes executed by the arithmetic portion with the use of the program are described below.", "Note that these processes cannot be clearly distinguished and one process also serves as another process or include part of another process in some cases.", "The program to be executed by the arithmetic portion 111 of the data processing device 100B is different from the program to be executed by the arithmetic portion of the data processing device in Embodiment 3 in that in the fifth step, the process is branched in accordance with the folded state of the position input portion 140B.", "Different processes will be described in detail below, and the above description is referred to for the other similar processes.", "<<Process for Generating First Image Data>> When the acquired folding data indicates the folded state, the arithmetic portion 111 generates the first image data.", "For example, in a manner similar to that of the fifth step of the program to be executed by the arithmetic portion 111 of the data processing device 100 in Embodiment 3, first image data VIDEO to be displayed on the display portion 130 with which the third region 140B(3) in the folded state overlaps is generated in accordance with the coordinates of the midpoint and whether the operation of “tap” or “flick” has been performed which is confirmed in the fifth step.", "The coordinates of the midpoint M can be associated with the position of the thumb joint portion (the vicinity of the thenar), the movable range of the thumb, or the like.", "In the case where an operation such as “tap” or “flick” is not detected in the region in which the midpoint M is not calculated in the first region 140(1) and the second region 140(2), it can be determined that a user operates the data processing device 100 with one hand, and image data that facilitates the operation of the data processing device 100B in the folded state can be generated in accordance with the coordinates of the midpoint M. For example, it is possible to generate the first image data VIDEO for one-hand operation that includes an image used for operation positioned in the display portion 130 with which the third region 140B(3) in the movable range of the thumb overlaps.", "Specifically, images used for operation (denoted by circles) can be positioned on a circular arc whose center is in the vicinity of the midpoint M (see FIG.", "21A).", "Among images used for operation, images that are used frequently may be positioned on a circular arc and images that are used less frequently may be positioned inside or outside the circular arc.", "As a result, a human interface with high operability can be provided in the data processing device 100B in the folded state.", "Furthermore, a novel data processing device with high operability can be provided.", "In the case where an operations such as “tap” or “flick” are detected in the region in which the midpoint M is not calculated in the first region 140(1) and the second region 140(2), it can be judged that the data processing device 100 is operated with both hands, so that the first image data VIDEO for two-hand operation can be displayed.", "Note that the first image data VIDEO for one-hand operation and the first image data VIDEO for two-hand operation can be the same.", "In the case where operations such as “tap” or “flick” are detected in the region in which midpoint M is not calculated in the first region 140(1) and the second region 140(2), operations other than the display of the imaged data VIDEO may be performed.", "For example, execution of the predetermined program, display or non-display of images or turning on or off a power source may be performed.", "<<Process for Generating Second Image Data>> When the acquired folding data indicates the unfolded state, the arithmetic portion 111 generates the second image data.", "For example, in a manner similar to that of the fifth step of the program to be executed by the arithmetic portion 111 of the data processing device 100 in Embodiment 3, first image data VIDEO to be displayed on the display portion 130 with which the third region 140B(3) in the folded state overlaps is generated in accordance with the coordinates of the midpoint and whether the operation of “tap” or “flick” has been performed which is confirmed in the fifth step.", "The coordinates of the midpoint M can be associated with the position of the thumb joint portion (the vicinity of the thenar), the movable range of the thumb, or the like.", "For example, it is possible to generate second image data VIDEO that includes an image used for operation not positioned in an area with which the movable range of the thumb overlaps.", "For example, in the case where an operation such as “tap” or “flick” is not detected in the region in which midpoint M is not calculated in the first region 140(1) and the second region 140(2), it can be determined that a user operates the data processing device 100 with one hand, and images used for operation (denoted by circles) can be positioned outside a circular arc whose center is in the vicinity of the midpoint M (see FIGS.", "21A to 21C).", "The position input portion 140B may be driven such that the position input portion 140B supplies positional data in response to sensing of an object that is proximate to or touches the circular arc or a region outside the circular arc.", "The user can support the data processing device 100B by holding the circular arc or a region inside the circular arc in the position input portion 140B in the unfolded state with one hand.", "The image used for operation and displayed outside the circular arc can be operated with the other hand.", "As a result, a human interface with high operability can be provided in the data processing device 100B in the unfolded state.", "Furthermore, a novel data processing device with high operability can be provided.", "In the case where an operations such as “tap” or “flick” are detected in the region in which midpoint M is not calculated in the first region 140(1) and the second region 140(2) (see FIGS.", "21A and 21B), it can be judged that the data processing device 100 is operated with both hands, so that the second image data VIDEO for two-hand operation can be displayed.", "Note that the first image data VIDEO for one-hand operation and the second image data VIDEO for two-hand operation can be the same.", "In the case where the operations such as “tap” or “flick” are detected in the region in which midpoint M is not calculated in the first region 140(1) and the second region 140(2), operations other than the display of the image data VIDEO may be performed.", "For example, execution of the predetermined program, display or non-display of images or turning on or off a power source may be performed.", "<Example of Structure of Data Processing Device> The data processing device described here is different from the data processing device described in Embodiment 2 or that described above in that the memory portion stores a program in accordance with which the arithmetic portion 111 executes the following seven steps, in which the area of the first figure and the area of the second figure are used instead of the length of the first line segment and the length of the second line segment (see FIG.", "22).", "Different processes will be described in detail below, and the above description is referred to for the other similar processes.", "<<Example of Program>> In a first step, the area of the first figure is determined using the first positional data supplied by the first region 140B(1) (see V1 in FIG.", "22).", "In a second step, the area of the second figure is determined using the second positional data supplied by the second region 140B(2) (see V2 in FIG.", "22).", "In a third step, the area of the first figure and the area of the second figure are compared with the predetermined area.", "The program proceeds to a fourth step when only one of the area of the first figure and the area of the second figure is larger than the predetermined area.", "The program proceeds to the first step in other cases (see V3 in FIG.", "22).", "Note that it is preferable that the predetermined area be larger than or equal to 1 cm2 and smaller than or equal to 8 cm2, and it is particularly preferable that the predetermined area be larger than or equal to 3 cm2 and smaller than or equal to 5 cm2.In a fourth step, the barycentric coordinates of the area which is larger than the predetermined area are determined (see V4 in FIG.", "22).", "In a fifth step, the folding data of the data processing device 100B is acquired.", "The program proceeds to the sixth step when the folding data indicates the folded state (see V5 in FIG.", "22).", "In a sixth step, whether operations of “tap”, “flick”, or the like are performed in a region in which the coordinates of the midpoint are not determined in the first region 140(1) and the second region 140(2) is checked (see V6 in FIG.", "22).", "In a seventh step, the first image data to be displayed on the display portion 130 which overlaps with the third region is generated in accordance with the barycentric coordinates and whether the operation of “tap” or “flick” has been performed confirmed in the sixth step (see V7 in FIG.", "22).", "In a fifth step, the folding data of the data processing device 100B is acquired.", "The program proceeds to the eighth step when the folding data indicates the folded state (see V5 in FIG.", "22).", "In an eighth step, the second image data to be displayed on the display portion with which the third region overlaps is generated in accordance with the barycentric coordinates (see V8 in FIG.", "22).", "The program is terminated in a ninth step (see V9 in FIG.", "22).", "This embodiment can be combined with any of the other embodiments in this specification as appropriate.", "Embodiment 5 In this embodiment, an operation example that can be used for the data processing device of one embodiment of the present invention will be described with reference to drawings.", "In the case where the data processing device 100 is held by a user, a specific region of the position input portion 140 is touched for a long time.", "In the display portion 130, display on a region overlapping with the region touched or rewriting data in the region overlapping with the region touched is not performed, whereby power consumption of the data processing device 100 can be suppressed.", "Since a region touched is a blind spot, visibility of the display image is not decreased when the display in the region overlapping with the region touched is stopped.", "Here, the region in which the display is stopped may be smaller than the region touched, for example.", "In that case, display appears to be performed even if a hand holding the data processing device moves a little.", "In the display portion 130, there may be a region in which display is not performed or a region in which a rewriting operation is not performed may be provided in a region other than touched region.", "For example, when the data processing device 100 is held by a user, there might be a region in which a user cannot view the display images near the region touched even though the region is not touched.", "A region in which display is not performed or a region in which a rewriting operation is not performed may be provided even in such a region.", "As an example of such a case, the case of contacting the display portion 130 with a palm can be given.", "When a palm contacts the display portion 130, the entire palm does not necessary contact the display portion.", "Even in a region with which palm is not in contact, however, the palm prevents a user from viewing the region in some cases.", "Thus, display or a rewriting operation is not necessarily performed in such a region.", "Here, the terms “display is not performed” and “rewriting operation is not performed” refer to not supplying a new image signal or charge to pixels in the display portion 130.Furthermore, the terms indicate that light is not supplied from the lighting device such as a backlight or a frontlight.", "For example, in the case of using a light-emitting element for the pixel, black display is performed in the region that is not supplied with an image signal in some cases.", "In addition, in the case where a display element that is not a light emitting element (e.g., a liquid crystal element) is used for the pixel, black display or white display is performed depending on a pixel configuration.", "Moreover, in the case of using a liquid crystal element as the pixel, an image which is displayed just before the supply of an image signal is stopped might be continuously displayed.", "For example, in the case of using a transistor including an oxide semiconductor in a channel portion, the same image may be continuously displayed because the off-state current of the transistor is extremely small.", "Furthermore, in the case of using a liquid crystal element for the pixel, black display may be performed in the region to which illumination light from the backlight is not supplied.", "In the case where a user holds the data processing device 100 with a hand and the like, the region held by the hand can be determined by various methods.", "For example, as described in the above embodiments, the edge detection processing is performed based on the first positional data L-INF (1) sensed by the first region 140(1) of the position input portion 140 and a second positional data L-INF (2) sensed by a second region 140(2), and when the arithmetic portion 111 determines that the area or the barycentric coordinates of the region surrounded by the edge is not changed for a certain period or longer, a portion of the display of the display portion 130 overlapping with the region is stopped.", "Alternatively, the display image rewriting of a portion of the display portion 130 that overlaps with the region is stopped.", "A similar processing may be performed using a third positional data L-INF (3) sensed by the third region 140(3).", "In the case where the data processing device 100 includes a fourth region 140(4) and a fifth region 140(5), for example, a similar processing may be performed based on fourth positional data L-INF (4) sensed by the fourth region 140(4) and a fifth positional data L-INF (5) sensed by the fifth region 140(5), for example.", "Alternatively, all the touched regions are simply detected, and the regions which are determined to be touched for a certain period or longer may be determined to be a region which is held by a hand or the like.", "Alternatively, the regions may be determined by using another sensor such as an acceleration sensor, an optical sensor, and an infrared ray sensor.", "In such a manner, the regions that are held by a hand can be determined by using and combining various methods.", "For example, as shown in FIG.", "32(A), a region A which is touched for a certain period or longer by a hand or the like does not react.", "In addition, a region B does not react because the region B is not in contact with anything.", "Next, as shown in FIG.", "32(B), when a finger or the like touches the region B, the region B reacts but the region A does not react.", "It is possible to operate the data processing device 100 by such a method.", "<<Example of Program>> An example of a program for making the arithmetic portion 111 execute the processing by which display is not performed in the region overlapping with the region touched for a certain period will be described with reference to FIG.", "23.The data processing device described here has a memory portion storing a program for making the arithmetic portion 111 execute the following eight steps.", "Note that the data processing device described in the above embodiments can be appropriately used as the data processing device.", "In a first step, a region a1 that is touched over the position input portion 140 is identified based on the first positional data L-INF (1) to the fourth positional data L-INF (4), and the like (see R1 in FIG.", "23).", "In a second step, the area and the barycentric coordinates of the region a1 are calculated (R2 in FIG.", "23).", "In a third step, the data processing device stands by for a certain period (R3 in FIG.", "23).", "Note that the stand-by time is preferably 1 second or longer and shorter than 30 seconds, and more preferably 1 second or longer and shorter than 15 seconds.", "When the stand-by time is too long, the display quality of the data processing device 100 is likely to decrease because the display in the display portion 130 overlapping with the region a1 might not be performed even after the holding position changed or holding is stopped.", "In a fourth step, a region a2 over the position input portion 140 which is touched is identified based on the first positional data L-INF (1) to the fourth positional data L-INF (4), or the like (R4 in FIG.", "23).", "In a fifth step, the area and the barycentric coordinates of the region a2 are calculated (R5 in FIG.", "23).", "In a sixth step, whether there are big differences in the areas and the barycentric coordinates between the region a1 and the region a2 is determined (R6 in FIG.", "23).", "In the case where there is no great difference in at least one of the areas and the barycentric coordinates between the region a1 and the region a2, a seventh step is performed (R7 in FIG.", "23).", "In the seventh step, display of the display portion 130 overlapping with the region a1 is stopped.", "Alternatively, display image rewriting of the display portion 130 overlapping with the region a1 is stopped.", "After that, the operation returns to the third step, and the data processing device stands by for a certain period.", "In the sixth step, in the case where there is a great difference in at least one of the areas and the barycentric coordinates between the region a1 and the region a2, the execution of the program is terminated in an eighth step.", "In such a manner, power consumption of the data processing device 100 can be suppressed.", "Note that although the display or the display image rewriting of the display portion 130 overlapping with the region a1 is stopped in the seventh step, one embodiment of the present invention is not limited thereto.", "For example, in the seventh step, when the display or the display image rewriting of the display portion 130 is stopped, it is also stopped not only in the region touched for a certain period but also in the vicinity thereof.", "Alternatively, the display or the display image rewriting of the display portion 130 is stopped in a region which is a slightly smaller than the region touched for a certain period.", "In the case of FIGS.", "2C, 2D, and 2E, for example, when the region touched for a certain period exists in any part of the fourth region 140(4), the display of a region of the display portion 130 that overlaps with the entire part of the first region 140(4) is stopped, or the display image rewriting is stopped.", "Similarly, for example, in the case where a region touched for a certain period exists in any part of the first region 140(1), the display of a region of the display portion 130 that overlaps with the entire part of the first region 140 (1) is stopped, or the display image rewriting is stopped.", "For example, since the fourth region 140(4) corresponds to the back surface of the data processing device 100, the fourth region 140(4) is a place which is hardly viewed by a user when the data processing device is held.", "Accordingly, when the display portion 130 may be not viewed from a user, the display or the display image rewriting is temporarily stopped in the entire part of such a region.", "However, when the third region 140(3) is not touched for a certain period, the display is restored, for example.", "Thus, the display can be performed only when a user is viewing, which results in reducing the power consumption.", "In the case where a user views the fourth region 140(4), the third region 140(3) substantially corresponds to the back surface of the data processing device 100.Thus, for example, in such a case, in a manner similar to the case of the fourth region 140(4), the display or the display image rewriting of the display portion 130 is stopped in the entire part of the third region 140(3).", "At least one of the region determining whether the region is touched for a long time; the region determining whether the region is touched for holding the data processing device by a user; the region in which the display of the display portion 130 is stopped; and the region in which the display image rewriting of the display portion 130 may be set to be a part of a region of the display portion 130.Furthermore, the position of the region, a judgment operation or a display operation performed in the region, and the like may be changed according to the situation.", "In addition, they may be set and changed by a user.", "For example, whether a region is touched for a long time or is touched for holding the device is not necessarily determined in the region corresponding to the front surface of the data processing device 100, such as in the third region 140(3).", "Furthermore, in such a region, the display or the display image rewriting of the display portion 130 is not necessarily stopped.", "In this manner, a user can view a display image even when the user rapidly changes the holding state of the data processing device 100.Furthermore, an acceleration sensor, a magnetic sensor, or the like may be used for determining whether a user is viewing the back surface or the front surface of the data processing device 100.By utilizing data of these sensors, circumstances can be precisely judged.", "In the case where the data processing device 100 is held by a user, when the region held by a user is included in the region determining touch action, touch action cannot be accurately determined, which causes malfunction or decrease in operability.", "In addition, there is a risk of dropping the data processing device 100 when a user holds a region of the data processing device 100 except for the region determining touch action.", "Hence, for example, a region touched by a user unintentionally is excluded from the region determining touch action in the position input portion 140.Furthermore, for example, a region of the position input portion 140 touched by a user for holding the data processing device 100 is excluded from the region determining touch action.", "Alternatively, for example, a region which cannot be touched even if a user intends to is excluded from the region determining touch action.", "For example, a region touched for a certain period is excluded from a region determining touch action in the position input portion 140.Thus, detection accuracy of touch action can be improved.", "Furthermore, favorable operability of the data processing device 100 can be obtained.", "As an example of a region which cannot be touched even if a user intends to, a region in contact with a palm can be given.", "In the case where a palm touches the region, the entire palm is not necessarily in contact with the region.", "Even if the region is not touched by a palm, the palm prevents the other hand from touching the region.", "As an example of a region which cannot be touched even if a user intends to touch, small spaces between fingers at the time of touching with a plurality of fingers can be given.", "The spaces cannot be touched with another hand.", "In this manner, a region which cannot be touched even if a user intends to touch may be excluded from the region determining touch action.", "In the case where the data processing device 100 is held by a hand or the like, the region held by a hand can be judged by various methods.", "For example, as described in the above embodiments, the edge detection process is performed based on the first positional data L-INF (1) sensed by the first region 140 (1) of the position input portion 140 and the second positional data L-INF (2) sensed by the second region 140 (2), and when the arithmetic portion 111 judges that the area or the barycentric coordinates of a region surrounded by the edge is not changed for a certain period or longer, the region is excluded from the region determining touch action.", "The similar processing may be performed using the third positional data L-INF (3) sensed by the third region 140 (3).", "In the case where the data processing device 100 includes the fourth region 140(4), the fifth region 140(5), and the like, the same processing may be performed based on the results of the fourth positional data L-INF (4) sensed by the fourth region 140(4) and the fifth positional data L-INF (5) sensed by the fifth region 140(5), and the like.", "Alternatively, all the touched regions are simply detected, and the region which is determined to be touched for a certain period or longer may be determined to be a region which is held by a hand, or the like.", "Alternatively, the regions may be determined by using another sensor such as an acceleration sensor, an optical sensor, and an infrared ray sensor.", "In such a manner, the regions that are held with a hand can be determined by using and combining various methods.", "<<Example of Program>> An example of a program for making the arithmetic portion 111 execute the processing by which a region touched for a certain period is excluded from the region determining touch action will be described with reference to FIG.", "24.The data-processing device described here has the memory portion storing a program for making the arithmetic portion 111 execute the following eight steps.", "Note that, the data processing device described in the above embodiments can be appropriately used as the data processing device.", "In a first step, a region a1 that is touched over the position input portion 140 is identified based on the first positional data L-INF (1) to the fourth positional data L-INF (4), and the like (see W1 in FIG.", "24).", "In a second step, the area and the barycentric coordinates of the region a1 are calculated (see W2 in FIG.", "24).", "In a third step, the data processing device stands by for a certain period (see W3 in FIG.", "24).", "The stand by time is preferably 1 second or longer and shorter than 30 seconds, and more preferably 1 second or longer and shorter than 15 seconds.", "When the stand-by time is too long, display quality of the data processing device 100 is likely to decrease because the display in the display portion 130 that overlaps with a region a1 is not performed in some cases even after the holding position changed or holding is stopped.", "In a fourth step, a region a2 that is touched over the position input portion 140 is identified based on the first positional data L-INF (1) to the fourth positional data L-INF (4), and the like (see W4 in FIG.", "24).", "In a fifth step, the area and the barycentric coordinates of a region a2 are calculated (see W5 in FIG.", "24).", "In a sixth step, whether there are big differences in the area and the barycentric coordinates between region a1 and the region a2 is judged (see W6 in FIG.", "24).", "In the case where there is no great difference in at least one of the areas and the barycentric coordinates between the region a1 and the region a2, a seventh step is performed (see W7 in FIG.", "24).", "In the seventh step, a region touched for a certain period is excluded from the region determining the touching action in the position input portion 140.In the sixth step, in the case where there is a great difference in at least one of the areas and the barycentric coordinates of the region a1 and the region a2, the execution of the program is terminated in an eighth step.", "In such a manner, detection accuracy of touch action of the data processing device 100 can be improved.", "Furthermore, favorable operability of the data processing device 100 can be obtained.", "Since a user does not need to be careful not to touch the region determining touch action, the data processing device 100 can be easily held.", "Since it becomes easy for a user to operate the data processing device 100 by one hand while holding the data processing device 100 by the other hand, the user can easily operate the data processing device 100 by both hands.", "Note that, although the region touched for a certain period is excluded from the region determining the touching action in the position input portion 140 in the seventh step, one embodiment of the present invention is not limited thereto.", "For example, in the seventh step, when the region touched for a certain period is excluded from the region determining the touch action in the position input portion 140, the vicinity of the region touched for a certain period can also be excluded from the region determining touch action.", "In the case of FIGS.", "2A and 2B, for example, when a region touched for a certain period exists in any part of the second region 140(2), the entire part of the second region 140(2) is excluded from the region determining touch action.", "Similarly, for example, when a region touched for a certain period exists in any part of the first region 140(1), the entire part of the first region 140(1) is excluded from the region determining touch action.", "Since the first region 140(1) and the second region 140(2) correspond to the side surfaces of the data processing device 100, the first region 140(1) and the second region 140(2) are regions that are easily touched.", "Thus, such regions may be temporarily excluded from the regions determining touch action.", "Note that, when the first region 140(1) and the second region 140(2) are not touched for a certain period, the regions are returned to the regions determining touch action.", "Accordingly, touch action can be utilized only when a user intends to perform operations.", "At least one of the region determining whether the region is touched for a long time, the region determining whether the region is touched by a user for holding the data processing device, and the region determining touch action may be set to be a part of the region of the display portion 130.Furthermore, the position of the region, a judgment operation or a display operation performed in the region, and the like may be changed according to the situation.", "In addition, they may be set and changed by a user.", "For example, whether a region is touched for a long time or is touched for holding the data processing device is not necessarily judged in the region corresponding to the front surface of the data processing device 100 such as the third region 140 (3).", "In addition, such a region is not necessarily excluded from the region determining touch action.", "Thus, a user can use the data processing device 100 smoothly in some cases.", "Note that instead of determining whether a region is touched for a certain period, a user may set a specific region which is excluded from the region determining touch action.", "For example, in a normal use, only a front surface such as the third region 140 (3) may be set to be the region determining touch action.", "Then, the other regions are excluded from the region determining touch action.", "The settings are changed according the usage of the data processing device.", "Thus, a user can easily operate the data processing device 100.Furthermore, an acceleration sensor, a magnetic sensor, or the like can be used for determining whether a user is viewing the back surface or the front surface of the data processing device 100.By utilizing the data of these sensors, circumstances can be precisely determined.", "The program described above is not only used in the data processing device 100 but also used in data processing devices in other embodiments.", "In FIG.", "25, a data processing device 100B which is unfolded is held by a left hand, and touch action is performed on the position input portion 140 overlapping with the display portion 130 by a right hand.", "With the use of the program described above in the data processing device 100B, the display of the region held by a left hand is stopped, which results in reducing the power consumption.", "Alternatively, with use of the program described above in the data processing device 100B, the region held by a left hand is excluded from the region determining touch action, whereby the detection accuracy of touch action of the data processing device 100B can be improved.", "Alternatively, favorable operability of the data processing device 100B can be obtained.", "When the data processing device 100 is held by a user, in a region of the display portion 130 overlapping with the region touched, an operation of not performing the display of the region or an operation of not performing rewriting operation of the region, and an operation of excluding the region from the region determining touch action can be carried out in combination.", "For example, display is not performed and touch action is not judged in the region touched by a user for holding the data processing device 100.This embodiment can be combined with any of the other embodiments in this specification as appropriate.", "Embodiment 6 In this embodiment, the structure of a display panel that can be used for a position input portion and a display device of the data processing device of one embodiment of the present invention will be described with reference to FIGS.", "26A to 26C.", "Note that the display panel described in this embodiment includes a touch sensor (a contact sensor device) that overlaps with a display portion; thus, the display panel can be called a touch panel (an input/output device).", "FIG.", "26A is a top view illustrating the structure of a display panel that can be used for a position input portion and a display device of the data processing device of one embodiment of the present invention.", "FIG.", "26B is a cross-sectional view taken along line A-B and line C-D in FIG.", "26A.", "FIG.", "26C is a cross-sectional view taken along line E-F in FIG.", "26A.", "<Top View> An input/output device 300 described as an example in this embodiment includes a display portion 301 (see FIG.", "26A).", "The display portion 301 includes a plurality of pixels 302 and a plurality of imaging pixels 308.The imaging pixels 308 can sense a touch of a finger or the like on the display portion 301.Thus, a touch sensor can be formed using the imaging pixels 308.Each of the pixels 302 includes a plurality of sub-pixels (e.g., a sub-pixel 302R).", "In addition, in the sub-pixels, light-emitting elements and pixel circuits that can supply electric power for driving the light-emitting elements are provided.", "The pixel circuits are electrically connected to wirings through which selection signals are supplied and wirings through which image signals are supplied.", "Furthermore, the input/output device 300 is provided with a scan line driver circuit 303g(1) that can supply selection signals to the pixels 302 and an image signal line driver circuit 303s(1) that can supply image signals to the pixels 302.Note that when the image signal line driver circuit 303s(1) is placed in a portion other than a bendable portion, malfunction can be inhibited.", "The imaging pixels 308 include photoelectric conversion elements and imaging pixel circuits that drive the photoelectric conversion elements.", "The imaging pixel circuits are electrically connected to wirings through which control signals are supplied and wirings through which power supply potentials are supplied.", "Examples of the control signals include a signal for selecting an imaging pixel circuit from which a recorded imaging signal is read, a signal for initializing an imaging pixel circuit, and a signal for determining the time it takes for an imaging pixel circuit to detect light.", "The input/output device 300 is provided with an imaging pixel driver circuit 303g(2) that can supply control signals to the imaging pixels 308 and an imaging signal line driver circuit 303s(2) that reads out imaging signals.", "Note that when the imaging signal line driver circuit 303s(2) is placed in a portion other than a bendable portion, malfunction can be inhibited.", "<Cross-Sectional View> The input/output device 300 includes a substrate 310 and a counter substrate 370 that faces the substrate 310 (see FIG.", "26B).", "The substrate 310 is a stacked body in which a flexible substrate 310b, a barrier film 310a that prevents diffusion of unintentional impurities to the light-emitting elements, and an adhesive layer 310c that attaches the barrier film 310a to the substrate 310b are stacked.", "The counter substrate 370 is a stacked body including a flexible substrate 370b, a barrier film 370a that prevents diffusion of unintentional impurities to the light-emitting elements, and an adhesive layer 370c that attaches the barrier film 370a to the substrate 370b (see FIG.", "26B).", "A sealant 360 attaches the counter substrate 370 to the substrate 310.The sealant 360 also serving as an optical adhesive layer has a refractive index higher than that of air.", "The pixel circuits and the light-emitting elements (e.g., a first light-emitting element 350R) and the imaging pixel circuits and photoelectric conversion elements (e.g., a photoelectric conversion element 308p) are provided between the substrate 310 and the counter substrate 370.<<Structure of Pixel>> Each of the pixels 302 includes a sub-pixel 302R, a sub-pixel 302G, and a sub-pixel 302B (see FIG.", "26C).", "The sub-pixel 302R includes a light-emitting module 380R, the sub-pixel 302G includes a light-emitting module 380G, and the sub-pixel 302B includes a light-emitting module 380B.", "For example, the sub-pixel 302R includes the first light-emitting element 350R and the pixel circuit that can supply electric power to the first light-emitting element 350R and includes a transistor 302t (see FIG.", "26B).", "Furthermore, the light-emitting module 380R includes the first light-emitting element 350R and an optical element (e.g., a coloring layer 367R).", "The transistor 302t includes a semiconductor layer.", "As the semiconductor layer, any layer which is semiconductive can be used.", "For example, a semiconductor such as silicon and germanium, a compound semiconductor such as gallium arsenide, an oxide semiconductor such as indium oxide, zinc oxide, indium gallium zinc oxide, and an organic semiconductor can be used.", "Furthermore, the semiconductor layer may have crystallinity such as a single crystal, a polycrystal, a microcrystal, and the like.", "Furthermore, the semiconductor layer may be amorphous.", "The characteristics of the oxide semiconductor are less likely to change even when a change in shape such as bending is given to the oxide semiconductor.", "Thus, an oxide semiconductor is preferably used for a semiconductor layer of a transistor to be formed over a flexible substrate.", "Although a channel-etched transistor that is a type of bottom-gate transistor is illustrated as the transistor 302t in this embodiment, a channel-protective transistor can be used.", "In addition, the transistor 302t may be a top-gate transistor.", "The transistor 302t may have a single gate structure including one channel formation region in a semiconductor layer, a double gate structure including two channel formation regions in a semiconductor layer, or a triple gate structure including three channel formation regions in a semiconductor layer.", "The transistor 302t may include a back gate electrode, with which the threshold value of the transistor 302t may be controlled.", "The light-emitting element 350R includes a first lower electrode 351R, an upper electrode 352, and a layer 353 containing a light-emitting organic compound between the first lower electrode 351R and the upper electrode 352 (see FIG.", "26C).", "The layer 353 containing a light-emitting organic compound includes a light-emitting unit 353a, a light-emitting unit 353b, and an intermediate layer 354 between the light-emitting units 353a and 353b.", "The light-emitting module 380R includes the first coloring layer 367R on the counter substrate 370.The coloring layer transmits light of a particular wavelength and is, for example, a layer that selectively transmits light of red, green, or blue color.", "A region that transmits light emitted from the light-emitting element as it is may be provided as well.", "The light-emitting module 380R, for example, includes the sealant 360 that is in contact with the first light-emitting element 350R and the first coloring layer 367R.", "The first coloring layer 367R is positioned in a region overlapping with the first light-emitting element 350R.", "Accordingly, part of light emitted from the first light-emitting element 350R passes through the sealant 360 that also serves as an optical adhesive layer and through the first coloring layer 367R and is emitted to the outside of the light-emitting module 380R as indicated by arrows in FIGS.", "26B and 26C.", "<<Structure of Input/Output Unit>> The input/output device 300 includes a light-blocking layer 367BM on the counter substrate 370.The light-blocking layer 367BM is provided so as to surround the coloring layer (e.g., the first coloring layer 367R).", "The input/output device 300 includes an anti-reflective layer 367p positioned in a region overlapping with the display portion 301.As the anti-reflective layer 367p, a circular polarizing plate can be used, for example.", "The input/output device 300 includes an insulating film 321.The insulating film 321 covers the transistor 302t.", "Note that the insulating film 321 can be used as a layer for planarizing unevenness caused by the pixel circuits.", "An insulating film on which a layer that can prevent diffusion of impurities to the transistor 302t and the like is stacked can be used as the insulating film 321.The input/output device 300 includes the light-emitting elements (e.g., the first light-emitting element 350R) over the insulating film 321.The input/output unit 300 includes, over the insulating film 321, a partition wall 328 that overlaps with an end portion of the first lower electrode 351R (see FIG.", "26C).", "In addition, a spacer 329 that controls the distance between the substrate 310 and the counter substrate 370 is provided on the partition wall 328.<<Structure of Image Signal Line Driver Circuit>> The image signal line driver circuit 303s (1) includes a transistor 303t and a capacitor 303c.", "Note that the image signal line driver circuit 303s(1) can be formed in the same process and over the same substrate as those of the pixel circuits.", "The transistor 303t has a structure similar to that of the transistor 302t.", "Note that the transistor 303t may have a structure different from that of the transistor 302t.", "<<Structure of Imaging Pixel>> The imaging pixels 308 each include a photoelectric conversion element 308p and an imaging pixel circuit for sensing light received by the photoelectric conversion element 308p.", "The imaging pixel circuit includes a transistor 308t.", "The transistor 308t has a structure similar to that of the transistor 302t.", "Note that the transistor 308t may have a structure different from that of the transistor 302t.", "For example, a PIN photodiode can be used as the photoelectric conversion element 308p.", "<<Other Structures>> The input/output device 300 includes a wiring 311 through which a signal can be supplied.", "The wiring 311 is provided with a terminal 319.Note that an FPC 309(1) through which a signal such as an image signal or a synchronization signal can be supplied is electrically connected to the terminal 319.The FPC 309(1) is preferably placed in a portion other than a bendable portion of the input/output unit 300.Moreover, the FPC 309(1) is preferably placed at almost the center of one side of a region surrounding the display portion 301, especially a side which is folded (a longer side in FIG.", "26A).", "Accordingly, the distance between an external circuit for driving the input/output unit 300 and the input/output unit 300 can be made short, resulting in easy connection.", "Furthermore, the center of gravity of the external circuit can be made almost the same as that of the input/output unit 300.As a result, the data processing device can be treated easily and mistakes such as dropping can be prevented.", "Note that a printed wiring board (PWB) may be attached to the FPC 309(1).", "Note that although the case where the light-emitting element is used as a display element is illustrated, one embodiment of the present invention is not limited thereto.", "For example, in this specification and the like, a display element, a display device which is a device including a display element, a light-emitting element, and a light-emitting device which is a device including a light-emitting element can employ a variety of modes or can include a variety of elements.", "Examples of a display element, a display device, a light-emitting element, or a light-emitting device include a display medium whose contrast, luminance, reflectance, transmittance, or the like is changed by electromagnetic action, such as an electroluminescence (EL) element (e.g., an EL element including organic and inorganic materials, an organic EL element, or an inorganic EL element), an LED (e.g., a white LED, a red LED, a green LED, or a blue LED), a transistor (a transistor that emits light depending on current), an electron emitter, a liquid crystal element, electronic ink, an electrophoretic element, a grating light valve (GLV), a plasma display panel (PDP), a display element using micro electro mechanical system (MEMS), a digital micromirror device (DMD), a digital micro shutter (DMS), MIRASOL (registered trademark), an interferometric modulator display (IMOD) element, a MEMS shutter display element, an optical-interference-type MEMS display element, an electrowetting element, a piezoelectric ceramic display, or a carbon nanotube.", "Note that examples of display devices having EL elements include an EL display.", "Examples of display devices including electron emitters are a field emission display (FED) and an SED-type flat panel display (SED: surface-conduction electron-emitter display).", "Examples of display devices including liquid crystal elements include a liquid crystal display (e.g., a transmissive liquid crystal display, a transflective liquid crystal display, a reflective liquid crystal display, a direct-view liquid crystal display, or a projection liquid crystal display).", "An example of a display device including electronic ink or electrophoretic elements is electronic paper.", "In the case of a transflective liquid crystal display or a reflective liquid crystal display, some of or all of pixel electrodes function as reflective electrodes.", "For example, some or all of pixel electrodes are formed to contain aluminum, silver, or the like.", "In such a case, a memory circuit such as an SRAM can be provided under the reflective electrodes.", "Accordingly, power consumption can be further reduced.", "In this specification and the like, for example, transistors with a variety of structures can be used as a transistor, without limitation to a certain type.", "For example, a transistor including a single-crystal silicon, or a transistor including a non-single-crystal semiconductor film typified by amorphous silicon, polycrystalline silicon, microcrystalline (also referred to as microcrystal, nanocrystal, or semi-amorphous) silicon, or the like can be used as a transistor.", "A thin film transistor (TFT) obtained by thinning such a semiconductor can be used.", "In the case of using the TFT, there are various advantages.", "For example, since the TFT can be formed at temperature lower than that of the case of using single-crystal silicon, manufacturing cost can be reduced or a manufacturing apparatus can be made larger.", "Since the manufacturing apparatus is made larger, the TFT can be formed using a large substrate.", "Therefore, many display devices can be formed at the same time at low cost.", "In addition, a substrate having low heat resistance can be used because of low manufacturing temperature.", "Therefore, the transistor can be formed using a light-transmitting substrate.", "Alternatively, transmission of light in a display element can be controlled by using the transistor formed using the light-transmitting substrate.", "Alternatively, part of a film included in the transistor can transmit light because the thickness of the transistor is small.", "Therefore, the aperture ratio can be improved.", "Note that when a catalyst (e.g., nickel) is used in the case of forming polycrystalline silicon, crystallinity can be further improved and a transistor having excellent electric characteristics can be formed.", "Accordingly, a gate driver circuit (e.g., a scan line driver circuit), a source driver circuit (e.g., a signal line driver circuit), and a signal processing circuit (e.g., a signal generation circuit, a gamma correction circuit, or a DA converter circuit) can be formed using the same substrate as a pixel portion.", "Note that when a catalyst (e.g., nickel) is used in the case of forming microcrystalline silicon, crystallinity can be further improved and a transistor having excellent electric characteristics can be formed.", "In this case, crystallinity can be improved by just performing heat treatment without performing laser irradiation.", "Accordingly, a gate driver circuit (e.g., a scan line driver circuit) and part of a source driver circuit (e.g., an analog switch) can be formed over the same substrate.", "Note that when laser irradiation for crystallization is not performed, unevenness in crystallinity of silicon can be suppressed.", "Therefore, high-quality images can be displayed.", "Note that it is possible to manufacture polycrystalline silicon or microcrystalline silicon without a catalyst (e.g., nickel).", "Note that although preferably, crystallinity of silicon is improved to polycrystal, microcrystal, or the like in the whole panel, the present invention is not limited to this.", "Crystallinity of silicon may be improved only in part of the panel.", "Selective increase in crystallinity can be achieved by selective laser irradiation or the like.", "For example, only a peripheral driver circuit region excluding pixels may be irradiated with laser light.", "Alternatively, only a region of a gate driver circuit, a source driver circuit, or the like may be irradiated with laser light.", "Alternatively, only part of a source driver circuit (e.g., an analog switch) may be irradiated with laser light.", "Accordingly, crystallinity of silicon can be improved only in a region in which a circuit needs to be operated at high speed.", "Since a pixel region is not particularly needed to be operated at high speed, even if crystallinity is not improved, the pixel circuit can be operated without problems.", "Thus, a region whose crystallinity is improved is small, so that manufacturing steps can be decreased.", "Thus, throughput can be increased and manufacturing cost can be reduced.", "Alternatively, since the number of necessary manufacturing apparatus is small, manufacturing cost can be reduced.", "Note that for example, a transistor including a compound semiconductor (e.g., SiGe, GaAs, and the like), an oxide semiconductor (e.g., ZnO, InGaZnO, IZO (indium zinc oxide) (registered trademark), ITO (indium tin oxide), SnO, TiO, and AlZnSnO (AZTO)), ITZO (In—Sn—Zn—O) (registered trademark), or the like; a thin film transistor obtained by thinning such a compound semiconductor or an oxide semiconductor; or the like can be used as a transistor.", "A thin film transistor obtained by thinning such a compound semiconductor or an oxide semiconductor, or the like can be used.", "Since manufacturing temperature can be lowered, such a transistor can be formed at room temperature, for example.", "Accordingly, the transistor can be formed directly on a substrate having low heat resistance, such as a plastic substrate or a film substrate.", "Note that such a compound semiconductor or an oxide semiconductor can be used not only for a channel portion of the transistor but also for other applications.", "For example, such a compound semiconductor or an oxide semiconductor can be used for a wiring, a resistor, a pixel electrode, a light-transmitting electrode, or the like.", "Since such an element can be formed at the same time as the transistor, cost can be reduced.", "Note that for example, a transistor or the like formed by an inkjet method or a printing method can be used as a transistor.", "Accordingly, a transistor can be formed at room temperature, can be formed at a low vacuum, or can be formed using a large substrate.", "Therefore, the transistor can be formed without use of a mask (reticle), so that the layout of the transistor can be easily changed.", "Alternatively, since the transistor can be formed without use of a resist, material cost is reduced and the number of steps can be reduced.", "Further, since a film can be formed where needed, a material is not wasted as compared to a manufacturing method by which etching is performed after the film is formed over the entire surface; thus, costs can be reduced.", "Note that for example, a transistor or the like including an organic semiconductor or a carbon nanotube can be used as a transistor.", "Accordingly, such a transistor can be formed using a substrate which can be bent.", "A device including a transistor which includes an organic semiconductor or a carbon nanotube can resist a shock.", "Note that transistors with a variety of different structures can be used as a transistor.", "For example, a MOS transistor, a junction transistor, a bipolar transistor, or the like can be used as a transistor.", "By using a MOS transistor as a transistor, the size of the transistor can be reduced.", "Thus, a large number of transistors can be mounted.", "With use of a bipolar transistor as the transistor, large current can flow.", "Thus, a circuit can be operated at high speed.", "Note that a MOS transistor and a bipolar transistor may be formed over one substrate.", "Thus, reduction in power consumption, reduction in size, high speed operation, and the like can be realized.", "Note that in this specification and the like, for example, a transistor with a multi-gate structure having two or more gate electrodes can be used as a transistor.", "With the multi-gate structure, a structure where a plurality of transistors are connected in series is provided because channel regions are connected in series.", "Thus, with the multi-gate structure, the amount of off-state current can be reduced and the withstand voltage of the transistor can be increased (the reliability can be improved).", "Alternatively, with the multi-gate structure, drain-source current does not change much even if drain-source voltage changes when the transistor operates in a saturation region, so that a flat slope of voltage-current characteristics can be obtained.", "By utilizing the flat slope of the voltage-current characteristics, an ideal current source circuit or an active load having an extremely large resistance can be realized.", "Accordingly, a differential circuit, a current mirror circuit, or the like having excellent properties can be realized.", "Note that a transistor with a structure where gate electrodes are formed above and below a channel can be used, for example.", "With the structure where the gate electrodes are formed above and below the channel, a circuit structure where a plurality of transistors are connected in parallel is provided.", "Thus, a channel region is increased, so that the amount of current can be increased.", "Alternatively, by using the structure where gate electrodes are formed above and below the channel, a depletion layer can be easily formed, so that subthreshold swing can be improved.", "Note that as a transistor, for example, it is possible to use a transistor with a structure where a gate electrode is formed above a channel region, a structure where a gate electrode is formed below a channel region, a staggered structure, an inverted staggered structure, a structure where a channel region is divided into a plurality of regions, a structure where channel regions are connected in parallel or in series, or the like.", "A transistor with any of a variety of structures such as a planar type, a FIN-type, a Tri-Gate type, a top-gate type, a bottom-gate type, a double-gate type (with gates above and below a channel), and the like can be used.", "Note that in this specification and the like, a transistor can be formed using any of a variety of substrates, for example.", "The type of a substrate is not limited to a certain type.", "As the substrate, a semiconductor substrate (e.g., a single crystal substrate or a silicon substrate), an SOI substrate, a glass substrate, a quartz substrate, a plastic substrate, a metal substrate, a stainless steel substrate, a substrate including stainless steel foil, a tungsten substrate, a substrate including tungsten foil, a flexible substrate, an attachment film, paper including a fibrous material, a base material film, or the like can be used, for example.", "As an example of a glass substrate, a barium borosilicate glass substrate, an aluminoborosilicate glass substrate, a soda lime glass substrate, or the like can be given.", "Examples of a flexible substrate, a flexible substrate, an attachment film, a base film, or the like are as follows: a plastic typified by polyethylene terephthalate (PET), polyethylene naphthalate (PEN), and polyether sulfone (PES); a synthetic resin such as acrylic; polypropylene; polyester; polyvinyl fluoride; polyvinyl chloride; polyester; polyamide; polyimide; aramid; epoxy; an inorganic vapor deposition film; and paper.", "Specifically, the use of semiconductor substrates, single crystal substrates, SOI substrates, or the like enables the manufacture of small-sized transistors with a small variation in characteristics, size, shape, or the like and with high current capability.", "A circuit using such transistors achieves lower power consumption of the circuit or higher integration of the circuit.", "Note that a transistor may be formed using one substrate, and then the transistor may be transferred to another substrate.", "Examples of a substrate to which a transistor is transferred include, in addition to the above-described substrates over which transistors can be formed, a paper substrate, a cellophane substrate, an aramid film substrate, a polyimide film substrate, a stone substrate, a wood substrate, a cloth substrate (including a natural fiber (e.g., silk, cotton, or hemp), a synthetic fiber (e.g., nylon, polyurethane, or polyester), a regenerated fiber (e.g., acetate, cupra, rayon, or regenerated polyester), or the like), a leather substrate, a rubber substrate, and the like.", "When such a substrate is used, a transistor with excellent properties or a transistor with low power consumption can be formed, a device with high durability, high heat resistance can be provided, or reduction in weight or thickness can be achieved.", "Note that all the circuits needed to realize a predetermined function can be formed over the same substrate (e.g., a glass substrate, a plastic substrate, a single crystal substrate, or an SOI substrate).", "Thus, costs can be reduced by reduction in the number of components, or the reliability can be improved by reduction in the number of connections to circuit components.", "Note that it is possible to form not all the circuits needed to realize the predetermined function over the same substrate.", "That is, a part of the circuits needed to realize the predetermined function can be formed over a substrate and another part of the circuits needed to realize the predetermined function can be formed over another substrate.", "For example, a part of the circuits needed to realize the predetermined function can be formed over a glass substrate and a part of the circuits needed to realize the predetermined function can be formed over a single crystal substrate (or an SOI substrate).", "Then, a single crystal substrate over which a part of the circuits needed to realize the predetermined function (such a substrate is also referred to as an IC chip) can be connected to a glass substrate by COG (chip on glass), and an IC chip can be provided on the glass substrate.", "Alternatively, an IC chip can be connected to a glass substrate using TAB (tape automated bonding), COF (chip on film), SMT (surface mount technology), a printed circuit board, or the like.", "When some of the circuits are formed using the same substrate as a pixel portion in this manner, cost can be reduced by reduction in the number of components or reliability can be improved by reduction in the number of connections to circuit components.", "In particular, a circuit with high driving voltage, a circuit with high driving frequency, or the like consumes a large amount of power in many cases.", "In order to deal with it, such a circuit is formed over a substrate (e.g., a single crystal substrate) which is different from a substrate where the pixel portion is formed, so that an IC chip is formed.", "By the use of this IC chip, an increase in power consumption can be prevented.", "For example, in this specification and the like, an active matrix method in which an active element is included in a pixel or a passive matrix method in which an active element is not included in a pixel can be used.", "In an active matrix method, as an active element (a non-linear element), not only a transistor but also various active elements (non-linear elements) can be used.", "For example, an MIM (metal insulator metal), a TFD (thin film diode), or the like can also be used.", "Since such an element has few numbers of manufacturing steps, manufacturing cost can be reduced or yield can be improved.", "Alternatively, since the size of the element is small, the aperture ratio can be improved, so that power consumption can be reduced or higher luminance can be achieved.", "As a method other than the active matrix method, the passive matrix method in which an active element (a non-linear element) is not used can also be used.", "Since an active element (a non-linear element) is not used, the number of manufacturing steps is small, so that manufacturing cost can be reduced or yield can be improved.", "Alternatively, since an active element (a non-linear element) is not used, the aperture ratio can be improved, so that power consumption can be reduced or higher luminance can be achieved, for example.", "This embodiment can be combined with any of the other embodiments in this specification as appropriate.", "Embodiment 7 In this embodiment, the structure of a display panel that can be used for a position input portion and a display device of the data processing device of one embodiment of the present invention will be described with reference to FIGS.", "27A and 27B and FIG.", "28.Note that the display panel described in this embodiment includes a touch sensor (a contact sensor device) that overlaps with a display portion; thus, the display panel can be called a touch panel (an input/output device).", "FIG.", "27A is a schematic perspective view of a touch panel 500 described as an example in this embodiment.", "Note that FIGS.", "27A and 27B illustrate only main components for simplicity.", "FIG.", "27B is a developed view of the schematic perspective view of the touch panel 500.FIG.", "28 is a cross-sectional view of the touch panel 500 taken along line X1-X2 in FIG.", "27A.", "The touch panel 500 includes a display unit 501 and a touch sensor 595 (see FIG.", "27B).", "Furthermore, the touch panel 500 includes a substrate 510, a substrate 570, and a substrate 590.Note that the substrate 510, the substrate 570, and the substrate 590 each have flexibility, for example.", "Note that in this specification and the like, a transistor can be formed using any of a variety of substrates, for example.", "The type of a substrate is not limited to a certain type.", "As the substrate, a semiconductor substrate (e.g., a single crystal substrate or a silicon substrate), an SOI substrate, a glass substrate, a quartz substrate, a plastic substrate, a metal substrate, a stainless steel substrate, a substrate including stainless steel foil, a tungsten substrate, a substrate including tungsten foil, a flexible substrate, an attachment film, paper including a fibrous material, a base material film, or the like can be used, for example.", "As an example of a glass substrate, a barium borosilicate glass substrate, an aluminoborosilicate glass substrate, a soda lime glass substrate, or the like can be given.", "Examples of a flexible substrate include a flexible synthetic resin such as plastics typified by polyethylene terephthalate (PET), polyethylene naphthalate (PEN), and polyether sulfone (PES), and acrylic.", "Examples of an attachment film are attachment films formed using polypropylene, polyester, polyvinyl fluoride, polyvinyl chloride, and the like.", "Examples of the material for the base film include polyester, polyamide, polyimide, inorganic vapor deposition film, and paper.", "Specifically, the use of semiconductor substrates, single crystal substrates, SOI substrates, or the like enables the manufacture of small-sized transistors with a small variation in characteristics, size, shape, or the like and with high current capability.", "A circuit using such transistors achieves lower power consumption of the circuit or higher integration of the circuit.", "The display portion 501 includes the substrate 510, a plurality of pixels over the substrate 510, and a plurality of wirings 511 through which signals are supplied to the pixels.", "The plurality of wirings 511 is led to a peripheral portion of the substrate 510, and part of the plurality of wirings 511 forms a terminal 519.The terminal 519 is electrically connected to an FPC 509(1).", "<Touch Sensor> The substrate 590 includes the touch sensor 595 and a plurality of wirings 598 electrically connected to the touch sensor 595.The plurality of wirings 598 is led to a peripheral portion of the substrate 590, and part of the plurality of wirings 598 forms a terminal for electrical connection to an FPC 509(2).", "Note that in FIG.", "27B, electrodes, wirings, and the like of the touch sensor 595 provided on the back side of the substrate 590 (on the back side of the diagram) are indicated by solid lines for clarity.", "As a touch sensor used as the touch sensor 595, a capacitive touch sensor is preferably used.", "Examples of the capacitive touch sensor are a surface capacitive touch sensor and a projected capacitive touch sensor.", "Examples of the projected capacitive touch sensor are a self capacitive touch sensor and a mutual capacitive touch sensor, which differ mainly in the driving method.", "The use of a mutual capacitive type is preferable because multiple points can be sensed simultaneously.", "An example of using a projected capacitive touch sensor is described below with reference to FIG.", "27B.", "Note that a variety of sensors that can sense the closeness or the contact of a sensing target such as a finger, can be used.", "The projected capacitive touch sensor 595 includes electrodes 591 and electrodes 592.The electrodes 591 are electrically connected to any of the plurality of wirings 598, and the electrodes 592 are electrically connected to any of the other wirings 598.The electrode 592 is in the form of a series of quadrangles arranged in one direction as illustrated in FIGS.", "27A and 27B.", "Each of the electrodes 591 is in the form of a quadrangle.", "A wiring 594 electrically connects two electrodes 591 arranged in a direction intersecting with the direction in which the electrode 592 extends.", "The intersecting area of the electrode 592 and the wiring 594 is preferably as small as possible.", "Such a structure allows a reduction in the area of a region where the electrodes are not provided, reducing unevenness in transmittance.", "As a result, unevenness in luminance of light from the touch sensor 595 can be reduced.", "Note that the shapes of the electrodes 591 and the electrodes 592 are not limited to the above-mentioned shapes and can be any of a variety of shapes.", "For example, the plurality of electrodes 591 may be provided so that space between the electrodes 591 are reduced as much as possible, and a plurality of electrodes 592 may be provided with an insulating layer sandwiched between the electrodes 591 and the electrodes 592 and may be spaced apart from each other to form a region not overlapping with the electrodes 591.In that case, between two adjacent electrodes 592, it is preferable to provide a dummy electrode which is electrically insulated from these electrodes, whereby the area of a region having a different transmittance can be reduced.", "The structure of the touch panel 500 is described with reference to FIG.", "28.The touch sensor 595 includes the substrate 590, the electrodes 591 and the electrodes 592 provided in a staggered arrangement on the substrate 590, an insulating layer 593 covering the electrodes 591 and the electrodes 592, and the wiring 594 that electrically connects the adjacent electrodes 591 to each other.", "An adhesive layer 597 attaches the substrate 590 to the substrate 570 so that the touch sensor 595 overlaps with the display portion 501.The electrodes 591 and the electrodes 592 are formed using a light-transmitting conductive material.", "As a light-transmitting conductive material, a conductive oxide such as indium oxide, indium tin oxide, indium zinc oxide, zinc oxide, or zinc oxide to which gallium is added can be used.", "The electrodes 591 and the electrodes 592 may be formed by depositing a light-transmitting conductive material on the substrate 590 by a sputtering method and then removing an unnecessary portion by any of various patterning techniques such as photolithography.", "The insulating layer 593 covers the electrodes 591 and the electrodes 592.Examples of a material for the insulating layer 593 are a resin such as acrylic or epoxy resin, a resin having a siloxane bond, and an inorganic insulating material such as silicon oxide, silicon oxynitride, or aluminum oxide.", "Furthermore, openings reaching the electrodes 591 are formed in the insulating layer 593, and the wiring 594 electrically connects the adjacent electrodes 591.The wiring 594 is preferably formed using a light-transmitting conductive material, in which case the aperture ratio of the touch panel can be increased.", "Moreover, the wiring 594 is preferably formed using a material that has higher conductivity than those of the electrodes 591 and the electrodes 592.One electrode 592 extends in one direction, and a plurality of electrodes 592 is provided in the form of stripes.", "The wiring 594 intersects with the electrode 592.Adjacent electrodes 591 are provided with one electrode 592 provided therebetween and are electrically connected by the wiring 594.Note that the plurality of electrodes 591 is not necessarily arranged in the direction orthogonal to one electrode 592 and may be arranged to intersect with one electrode 592 at an angle of less than 90 degrees.", "One wiring 598 is electrically connected to any of the electrodes 591 and 592.Part of the wiring 598 serves as a terminal.", "For the wiring 598, a metal material such as aluminum, gold, platinum, silver, nickel, titanium, tungsten, chromium, molybdenum, iron, cobalt, copper, or palladium or an alloy material containing any of these metal materials can be used.", "Note that an insulating layer that covers the insulating layer 593 and the wiring 594 may be provided to protect the touch sensor 595.Furthermore, a connection layer 599 electrically connects the wiring 598 to the FPC 509(2).", "As the connection layer 599, any of various anisotropic conductive films (ACF), anisotropic conductive pastes (ACP), or the like can be used.", "The adhesive layer 597 has a light-transmitting property.", "For example, a thermosetting resin or an ultraviolet curable resin can be used; specifically, a resin such as an acrylic resin, a urethane resin, an epoxy resin, or a resin having a siloxane bond can be used.", "Display Portion The touch panel 500 includes a plurality of pixels arranged in a matrix.", "Each of the pixels includes a display element and a pixel circuit for driving the display element.", "In this embodiment, an example of using an organic electroluminescent element that emits white light as a display element will be described; however, the display element is not limited to such element.", "As the display element, for example, other than organic electroluminescent elements, any of a variety of display elements such as display elements (electronic ink) that perform display by an electrophoretic method, an electronic liquid powder method, or the like; MEMS shutter display elements; optical interference type MEMS display elements; and liquid crystal elements can be used.", "Note that a structure suitable for employed display elements can be selected from among a variety of structures of pixel circuits.", "The substrate 510 is a stacked body in which a flexible substrate 510b, a barrier film 510a that prevents diffusion of unintentional impurities to light-emitting elements, and an adhesive layer 510c that attaches the barrier film 510a to the substrate 510b are stacked.", "The substrate 570 is a stacked body in which a flexible substrate 570b, a barrier film 570a that prevents diffusion of unintentional impurities to the light-emitting elements, and an adhesive layer 570c that attaches the barrier film 570a to the substrate 570b are stacked.", "A sealant 560 attaches the substrate 570 to the substrate 510.The sealant 560, also serving as an optical adhesive layer, has a refractive index higher than that of air.", "The pixel circuits and the light-emitting elements (e.g., a first light-emitting element 550R) are provided between the substrate 510 and the substrate 570.<<Structure of Pixels>> A pixel includes a sub-pixel 502R, and the sub-pixel 502R includes a light-emitting module 580R.", "The sub-pixel 502R includes the first light-emitting element 550R and the pixel circuit that can supply electric power to the first light-emitting element 550R and includes a transistor 502t.", "Furthermore, the light-emitting module 580R includes the first light-emitting element 550R and an optical element (e.g., a coloring layer 567R).", "The first light-emitting element 550R includes a lower electrode, an upper electrode, and a layer containing a light-emitting organic compound between the lower electrode and the upper electrode.", "The light-emitting module 580R includes the first coloring layer 567R on the substrate 570.The coloring layer transmits light of a particular wavelength and is, for example, a layer that selectively transmits light of red, green, or blue color.", "A region that transmits light emitted from the light-emitting element as it is may be provided as well.", "The light-emitting module 580R includes the sealant 560 that is in contact with the first light-emitting element 550R and the first coloring layer 567R.", "The first coloring layer 567R is positioned in a region overlapping with the first light-emitting element 550R.", "Accordingly, part of light emitted from the first light-emitting element 550R passes through the sealant 560 that also serves as an optical adhesive layer and through the first coloring layer 567R and is emitted to the outside of the light-emitting module 580R as indicated by arrows in FIG.", "28.<<Structure of Display Portion>> The display portion 501 includes a light-blocking layer 567BM on the substrate 570.The light-blocking layer 567BM is provided so as to surround the coloring layer (e.g., the first coloring layer 567R).", "The display portion 501 includes an anti-reflective layer 567p positioned in a region overlapping with pixels.", "As the anti-reflective layer 567p, a circular polarizing plate can be used, for example.", "The display portion 501 includes an insulating film 521.The insulating film 521 covers the transistor 502t.", "Note that the insulating film 521 can be used as a layer for planarizing unevenness due to the pixel circuit.", "An insulating film on which a layer that can prevent diffusion of impurities to the transistor 502t and the like is stacked can be used as the insulating film 521.The display portion 501 includes the light-emitting elements (e.g., the first light-emitting element 550R) over the insulating film 521.The display portion 501 includes, over the insulating film 521, a partition wall 528 that overlaps with an end portion of the first lower electrode.", "In addition, a spacer that controls the distance between the substrate 510 and the substrate 570 is provided on the partition wall 528.<<Structure of Image Signal Line Driver Circuit>> The image signal line driver circuit 503s(1) includes a transistor 503t and a capacitor 503c.", "Note that the image signal line driver circuit 503s(1) can be formed in the same process and over the same substrate as those of the pixel circuits.", "<<Other Structures>> The display portion 501 includes the wirings 511 through which signals can be supplied.", "The wirings 511 are provided with the terminal 519.Note that the FPC 509(1) through which a signal such as an image signal or a synchronization signal can be supplied is electrically connected to the terminal 519.Note that a printed wiring board (PWB) may be attached to the FPC 509(1).", "This embodiment can be combined with any of the other embodiments in this specification as appropriate.", "Embodiment 8 In this embodiment, a method for manufacturing a foldable device that can be used for the data processing device or an electronic device of one embodiment of the present invention will be described with reference to FIGS.", "29A to 29D, FIGS.", "30A to 30D, and FIGS.", "31A to 31D.", "As examples of the foldable device, a display device, a light-emitting device, an input device, and the like can be given.", "As examples of the input device, a touch sensor, a touch panel, and the like can be given.", "As examples of the light-emitting device, an organic EL panel, a lighting device, and the like can be given.", "As examples of the display device, a light-emitting device, an organic EL panel, a liquid crystal display device, and the like can be given.", "Note that functions of an input device such as a touch sensor and the like are provided in the display device and or the light-emitting device in some cases.", "For example, a counter substrate (e.g., a substrate not provided with a transistor) included in the display device or the light-emitting device is provided with a touch sensor in some cases.", "Alternatively, an element substrate (e.g., a substrate provided with a transistor) included in the display device or the light-emitting device is provided with a touch sensor in some cases.", "Alternatively, the counter substrate included in the display device or the light-emitting device and the element substrate included in the display device or the light-emitting device are provided with touch sensors in some cases.", "First, a separation layer 703 is formed over a formation substrate 701, and a layer 705 to be separated is formed over the separation layer 703 (FIG.", "29A).", "Furthermore, a separation layer 723 is formed over a formation substrate 721, and a layer 725 to be separated is formed over the separation layer 723 (FIG.", "29B).", "Furthermore, in the case of using a tungsten film as a separation layer, a tungsten oxide film can be formed on a surface of the tungsten film by any of the following methods: performing a plasma treatment over the surface of the tungsten film using a gas containing oxygen such as N2O, annealing the tungsten film in a gas atmosphere containing oxygen.", "Alternatively, a tungsten oxide film can be formed by method such as sputtering in gas atmosphere containing oxygen.", "In this manner, the oxide tungsten film may be formed between a separation layer and a layer to be separated.", "In a separating and transferring process of the tungsten oxide film, it is preferable that the tungsten oxide film be mainly WOx whose x is smaller than 3.In the case where WOx is WnO(3n−1) or WnO(3n−2), which is a homologous series, shear is easily caused by heating because there is a crystal optical shear plane therein.", "The tungsten oxide film is formed, so that separation of the layer to be separated from a substrate can be performed with small force.", "Alternatively, it is also possible that a tungsten film is not formed and only the tungsten oxide film is formed as the separation layer.", "For example, the tungsten oxide film may be formed by the following methods: performing a plasma treatment using a gas containing oxygen with respect to a sufficiently thin tungsten film, annealing the sufficiently thin tungsten film in a gas atmosphere containing oxygen.", "Alternatively, the tungsten oxide film may be formed by a method such as a sputtering method in a gas atmosphere containing oxygen.", "Here, when the tungsten oxide film is separated at the interface with the layer to be separated, the tungsten oxide film remains on the layer to be separated side in some cases.", "When the tungsten oxide film remains, the characteristics of the transistor are adversely affected in some cases.", "Thus, after a step of separating the separation layer and the layer to be separated, the step of removing the tungsten oxide film is preferably included.", "In the above method of separating from the substrate, N2O plasma treatment is not necessarily performed, and the step of removing the tungsten oxide film can be omitted.", "In that case, the device can be manufactured more easily.", "Furthermore, in one embodiment of the present invention, a tungsten film with a thickness of greater than or equal to 0.1 nm and less than 200 nm is formed over the substrate.", "As the separation layer, a film containing molybdenum, titanium, vanadium, tantalum, silicon, aluminum, or an alloy thereof can be used, besides a tungsten film.", "Furthermore, it is also possible to use a stack of such a film and an oxide film.", "The separation layer is not limited to an inorganic film, and an organic film such as polyimide may be used.", "In the case of using an organic resin for the separation layer, a process temperature needs to be lower than or equal to 350° C. when polysilicon is used as an active layer of the transistor.", "Thus, dehydrogenation baking for silicon crystallization, hydrogenation for termination of defects in silicon, or activation of a doped region cannot be performed sufficiently, so that the performance of the transistor is limited.", "On the other hand, in the case of using an inorganic film, the process temperature can be higher than 350° C., and excellent characteristics of a transistor can be obtained.", "In the case of using the organic resin for the separation layer, the organic resin or a functional element is damaged by laser irradiation at the time of crystallization; thus, it is preferable to use an inorganic film for the separation layer because such a problem is not caused.", "Furthermore, in the case of using the organic resin for the separation layer, the organic resin shrinks by laser irradiation for separating the resin and contact failure is caused in the contact portion of the terminal of an FPC or the like, which makes it difficult for functional elements with many terminals a high-definition display of FPC, or the like to separate and transpose with high yield.", "In the case of using an inorganic film for the separation layer, there is no such limitation, and functional elements with many terminals of high-definition display and the like, or the like can be separated and transferred with high yield.", "In the method for separating and transferring the functional element from the substrate of one embodiment of the present invention, an insulating film and a transistor can be formed over the formation substrate at a temperature of lower than or equal to 600° C. In that case, a high-temperature polysilicon or CG silicon (registered trademark) can be used for a semiconductor layer.", "With use of a conventional production line for high-temperature polysilicon or CG silicon (registered trademark), a semiconductor device with a high operation speed, a high gas barrier property, and high reliability can be mass-produced.", "In that case, with use of the insulating layer and the transistor formed through the process at the temperature of lower than or equal to 600° C., insulating layers having an excellent gas barrier property formed at the temperature of lower than or equal to 600° C. can be provided above and below an organic EL element.", "Accordingly, entry of impurities such as moisture into the organic EL element or the semiconductor layer can be suppressed, whereby an extraordinarily reliable light-emitting device can be obtained as compared with the case of using the organic resin or the like as the separation layer.", "Alternatively, the insulating layer and the transistor can be formed over the formation substrate at 500° C. or lower.", "In that case, low-temperature polysilicon or an oxide semiconductor can be used for the semiconductor layer, and mass production is possible with use of a conventional production line for low temperature polysilicon.", "Also in that case, with use of the insulating layer and the transistor formed through the process at the temperature of lower than or equal to 500° C., insulating layers having an excellent gas barrier property formed at the temperature of lower than or equal to 500° C. can be provided above and below the organic EL element.", "Accordingly, the entry of impurities such as moisture into the inorganic EL element or the semiconductor layer is suppressed, whereby a highly reliable light-emitting device can be obtained as compared with the case of using the organic resin as the separation layer.", "Alternatively, the insulating layer and the transistor can be formed over the formation substrate at 400° C. or lower.", "In that case, amorphous silicon or the oxide semiconductor can be used for the semiconductor layer, and mass production is possible with use of a conventional production line for amorphous silicon.", "Also in that case, with use of the insulating layer and the transistor formed through the process at the temperature of 400° C. or lower, the insulating layers having an excellent gas barrier property formed at the temperature of 400° C. or lower can be provided above and below the organic EL element.", "Accordingly, entry of impurities such as moisture into the organic EL element or the semiconductor layer is suppressed, whereby a highly reliable light emitting device can be obtained as compared with a case of using the organic resin and the like as the separation layer.", "Next, the formation substrate 701 and the formation substrate 721 are attached to each other by using a bonding layer 707 and a frame-shaped bonding layer 711 so that the surfaces over which the layers to be separated are formed face each other, and then, the bonding layer 707 and the frame-shaped bonding layer 711 are cured (FIG.", "29C).", "Here, the frame-shaped bonding layer 711 and the bonding layer 707 in a region surrounded by the frame-shaped bonding layer 711 are provided over the layer 725 to be separated and after that, the formation substrate 701 and the formation substrate 721 face each other and are attached to each other.", "Note that the formation substrate 701 and the formation substrate 721 are preferably attached to each other in a reduced-pressure atmosphere.", "Note that although FIG.", "29C illustrates the case where the separation layer 703 and the separation layer 723 are different in size, separation layers of the same size as illustrated in FIG.", "29D may be used.", "The bonding layer 707 is provided to overlap with the separation layer 703, the layer 705 to be separated, the layer 725 to be separated, and the separation layer 723.Then, an end portion of the bonding layer 707 is preferably positioned on an inner side of at least an end portion of either the separation layer 703 or the separation layer 723 (the separation layer which is desirably separated from the substrate first).", "Accordingly, strong adhesion between the formation substrate 701 and the formation substrate 721 can be suppressed; thus, a decrease in the yield of a subsequent separation process can be suppressed.", "Next, a first separation trigger 741 from the substrate is formed by laser light irradiation (FIGS.", "30A and 30B).", "Either the formation substrate 701 or the formation substrate 721 may be separated first.", "In the case where the separation layers differ in size, a substrate over which a larger separation layer is formed may be separated first or a substrate over which a smaller separation layer is formed may be separated first.", "In the case where an element such as a semiconductor element, a light-emitting element, or a display element is formed only over one of the substrates, the substrate on the side where the element is formed may be separated first or the other substrate may be separated first.", "Here, an example in which the formation substrate 701 is separated first is described.", "A region where the bonding layer 707 in a cured state or the frame-shaped bonding layer 711 in a cured state, the layer 705 to be separated, and the separation layer 703 overlap with one another is irradiated with laser light.", "Here, the bonding layer 707 is in a cured state and the frame-shaped bonding layer 711 is not in a cured state, and the bonding layer 707 in a cured state is irradiated with laser light (see an arrow P3 in FIG.", "30A).", "The first separation trigger 741 (see a region surrounded by a dashed line in FIG.", "30B) can be formed by cracking (causing break or crack) at least the first layer (a layer provided between the layer 705 to be separated and the separation layer 703, e.g., a tungsten oxide film).", "At this time, not only the first layer but also the separation layer 703, the bonding layer 707, or another layer included in the layer 705 to be separated may be partly removed.", "It is preferable that laser light irradiation be performed from the substrate side provided with the separation layer that is desirably separated.", "In the case where a region where the separation layer 703 and the separation layer 723 overlap with each other is irradiated with laser light, the formation substrate 701 and the separation layer 703 can be selectively separated by cracking only the layer 705 to be separated between the layer 705 to be separated and the layer 725 to be separated (see a region surrounded by a dotted line in FIG.", "30B).", "When the separation trigger from the substrate is formed in both the layer 705 to be separated on the separation layer 703 side and the layer 725 to be separated on the separation layer 723 side in the case where the region where the separation layer 703 and the separation layer 723 overlap with each other is irradiated with laser light, it might be difficult to selectively separate one of the formation substrates.", "Therefore, laser light irradiation conditions might be restricted so that only one of the layers to be separated is cracked.", "The first separation trigger 741 from the substrate may be formed by a sharp knife such as a cutter, without limitation to the laser light irradiation, or the like.", "Then, the layer 705 to be separated and the formation substrate 701 are separated from each other from the formed first separation trigger 741 (FIGS.", "30C and 30D).", "Accordingly, the layer 705 to be separated can be transferred from the formation substrate 701 to the formation substrate 721.The layer 705 which is separated from the formation substrate 701 in the step in FIG.", "30D is attached to a substrate 731 with a bonding layer 733, and the bonding layer 733 is cured (FIG.", "31A).", "Next, a second separation trigger 743 from the substrate is formed by a sharp knife such as a cutter (FIGS.", "31B and 31C).", "The second separation trigger 743 from the substrate is formed by the laser light irradiation, without limitation to the sharp knife such as a cutter, or the like.", "In the case where the substrate 731 on the side where the separation layer 723 is not provided can be cut by a knife or the like, a cut may be made in the substrate 731, the bonding layer 733, and the layer 725 to be separated (see arrows P5 in FIG.", "31B).", "Accordingly, part of the first layer can be removed; thus, the second separation trigger 743 from the substrate can be formed (see a region surrounded by a dashed line in FIG.", "31C).", "As illustrated in FIGS.", "31B and 31C, in the case where the formation substrate 721 and the substrate 731 are attached to each other using the bonding layer 733 in a region not overlapping with the separation layer 723, yield of a process for separation from the substrate might be decreased depending on a degree of adhesion between the formation substrate 721 side and the substrate 731 side.", "Therefore, it is preferable to make a cut in a frame shape in a region where the bonding layer 733 in a cured state and the separation layer 723 overlap with each other to form the second separation trigger 743 from the substrate in a form of a solid line.", "Accordingly, the yield of a process for separation from the substrate can be improved.", "Then, the layer 725 to be separated and the formation substrate 721 are separated from each other from the formed second separation trigger 743 from the substrate (FIG.", "31D).", "Accordingly, the layer 725 to be separated can be transferred from the formation substrate 721 to the substrate 731.For example, in the case where the tungsten oxide film, which is tightly anchored by N2O plasma or the like is formed on an inorganic film such as a tungsten film, adhesion can be relatively high in deposition.", "After that, when a separation trigger is formed, cleavage occurs therefrom, whereby a layer to be separated is easily separated from the formation surface and transferred to another substrate.", "The formation substrate 721 and the layer 725 to be separated may be separated by filling the interface between the separation layer 723 and the layer 725 to be separated with a liquid such as water.", "A portion between the separation layer 723 and the layer 725 to be separated absorbs a liquid through capillarity action, whereby an adverse effect (e.g., a phenomenon in which a semiconductor element is damaged by static electricity) on the functional element such as an FET included in the layer 725 to be separated due to static electricity caused at the time of separation from the substrate can be suppressed.", "When a bond of M-O—W (M represents a given element) is divided by application of physical force, a liquid is absorbed in the separation portion, whereby the bond becomes a bond of M-OH HO—W and the separation is promoted.", "Note that a liquid may be sprayed in an atomized form or in a vaporized form.", "As the liquid, pure water, an organic solvent, or the like can be used; a neutral, alkaline, or acid aqueous solution, an aqueous solution in which salt is dissolved, and the like may be used.", "The temperature of the liquid and the substrate at the time of dynamic separation is set in the range from room temperature to 120° C., and preferably set to 60° C. to 90° C. In the method for separation from the substrate of one embodiment of the present invention described above, separation of the formation substrate is performed in such a manner that the second separation trigger 743 from the substrate is formed by a sharp knife or the like so that the separation layer and the layer to be separated are made in a state where separating can be easily performed.", "Accordingly, the yield of the process for separation from substrate can be improved.", "In addition, bonding of a substrate with which a device is to be formed can be performed after the following procedure: a pair of formation substrates each provided with the layer to be separated are attached to each other and then, separating each formation substrate is performed.", "This means that formation substrates having low flexibility can be attached to each other when the layers to be separated are attached to each other.", "Accordingly, alignment accuracy at the time of attachment can be improved as compared to the case where flexible substrates are attached to each other.", "Note that this embodiment can be combined with any of the other embodiments and examples described in this specification as appropriate.", "EXPLANATION OF REFERENCE 100: data processing device, 101: housing, 110: arithmetic unit, 111: arithmetic portion, 112: memory portion, 114: transmission path, 115: input/output interface, 120: input/output unit, 130: display portion, 131: keyboard, 140: position input portion, 141: substrate, 142: proximity sensor, 145: input/output portion, 150: sensor portion, 151: sensor, 152: arrow, 159: sign, 160: communication portion, 300: input/output unit, 301: display portion, 302: pixel, 308: imaging pixel, 309: FPC, 310: substrate, 311: wiring, 319: terminal, 321: insulating film, 328: partition wall, 329: spacer, 352: upper electrode, 353: layer, 354: intermediate layer, 360: sealant, 370: counter substrate, 500: touch panel, 501: display portion, 509: FPC, 510: substrate, 511: wiring, 519: terminal, 521: insulating film, 528: partition wall, 560: sealant, 570: substrate, 590: substrate, 591: electrode, 592: electrode, 593: insulating layer, 594: wiring, 595: touch sensor, 597: adhesive layer, 598: wiring, 599: connection layer, 100B: data processing device, 120B: input/output unit, 130B: display portion, 13a: connecting member, 13b: connecting member, 140 (1): region, 140 (2): region, 140 (3): region, 140 (4): region, 140 (5): region, 140B: position input portion, 140B (1): region, 140B (2): region, 140B (3): region, 15a: supporting member, 15b: supporting member, 302B: sub-pixel, 302G: sub-pixel, 302R: sub-pixel, 302t: transistor, 303c: capacitor, 303g (1): scan line driver circuit, 303g (2): imaging pixel driver circuit, 303s (1): image signal line driver circuit, 303s (2): imaging signal line driver circuit, 303t: transistor, 308p: photoelectric conversion element, 308t: transistor, 310a: barrier film, 310b: substrate, 310c: adhesive layer, 350R: light-emitting element, 351R: lower electrode, 353a: light-emitting unit, 353b: light-emitting unit, 367BM: light-blocking layer, 367p: anti-reflective layer, 367R: coloring layer, 370a: barrier film, 370b: substrate, 370c: adhesive layer, 380B: light-emitting module, 380G: light-emitting module, 380R: light-emitting module, 502R: sub-pixel, 502t: transistor, 503c: capacitor, 503s: image signal line driver circuit, 503t: transistor, 510a: barrier film, 510b: substrate, 510c: adhesive layer, 550R: light-emitting element, 567BM: light-blocking layer, 567p: anti-reflective layer, 567R: coloring layer, 570a: barrier film, 570b: substrate; 570c: adhesive layer, 580R: light-emitting module, 701: formation substrate, 703: separation layer, 705: layer to be separated, 707: bonding layer, 711: frame-shaped bonding layer, 721: formation substrate, 723: separation layer, 725: layer to be separated; 731: substrate, 733: bonding layer, 741: first separation trigger, and 743: second separation trigger.", "This application is based on Japanese Patent Application serial no.", "2013-248392 filed with Japan Patent Office on Nov. 29, 2013, the entire contents of which are hereby incorporated by reference." ] ]
Patent_15874279
[ [ "SYSTEMS AND METHODS FOR CERAMIC MATRIX COMPOSITES", "Methods for fabricating a ceramic matrix composite are disclosed.", "A fiber preform may be placed in a mold.", "An aqueous solution may be added to the fiber preform.", "The aqueous solution may include water, carbon nanotubes, and a binder.", "The preform may be frozen.", "Freezing the preform may cause the water to expand and separate fibers in the fiber preform.", "The carbon nanotubes may bond to the fibers.", "The preform may be freeze dried to remove the water.", "The preform may then be processed according to standard CMC process." ], [ "1.A ceramic matrix composite formed by a process comprising: inserting a fiber tow in a mold; introducing an aqueous solution comprising water, carbon nanotubes, and a binder into the mold; freezing the aqueous solution, wherein the freezing the aqueous solution separates fibers within the fiber tow; freeze drying the aqueous solution, wherein the freeze drying removes the water from the mold; and processing the mold via at least one of slurry casting, chemical vapor infiltration, polymer infiltration and pyrolysis, or melt infiltration.", "2.The ceramic matrix composite of claim 1, wherein the process further comprises converting the carbon nanotubes to at least one of boron carbide or boron nitride nanotubes.", "3.The ceramic matrix composite of claim 1, wherein the process further comprises converting the carbon nanotubes to silicon carbide nanotubes.", "4.The ceramic matrix composite of claim 1, wherein the carbon nanotubes are bonded to fibers.", "5.The ceramic matrix composite of claim 1, wherein the carbon nanotubes form an interfacial region surrounding the fibers." ], [ "<SOH> BACKGROUND <EOH>Fiber-reinforced ceramic matrix composites (“CMCs”) can exhibit exceptional high temperature properties such as high strength, modulus, and toughness.", "These properties result from the incorporation of high strength fibers into a stable atrix.", "The high strength fibers may have a coating which creates a weak interface between the fibers and the matrix material.", "The fibers are typically incorporated into the composite in fiber tows, which are bundles of individual fiber filaments.", "Each fiber tow may remain as a discrete entity during CMC processing as opposed to having the individual fiber filaments being distributed uniformly throughout the composite.", "The weak interface between the fibers and the matrix material enables debonding of the fibers from the matrix, allowing for crack deflection, bridging and enhanced material strength and toughness." ], [ "<SOH> SUMMARY <EOH>A method for fabricating a composite material may comprise adding a slurry to a fiber preform comprising a plurality of fiber tows.", "The slurry may be intermixed with carbon nanotubes.", "The method may comprise freezing the fiber preform.", "The method may comprise freeze drying the fiber preform.", "In various embodiments, the freezing the fiber preform may separate fibers in the plurality of fiber tows.", "The slurry may comprise a binder.", "The method may comprise heat treating the fiber preform.", "The heat treating may comprise converting the carbon nanotubes to at least one of boron carbide or boron nitride nanotubes.", "The heat treating may comprise converting the carbon nanotubes to silicon carbide nanotubes.", "The carbon nanotubes may bond to fibers in the fiber tows.", "The method may comprise processing the fiber preform via at least one of slurry casting, chemical vapor infiltration, polymer infiltration and pyrolysis, or melt infiltration.", "A method of manufacturing an aircraft component may comprise inserting a fiber tow in a mold.", "An aqueous solution comprising water, carbon nanotubes, and a binder may be introduced into the mold.", "The aqueous solution may be frozen.", "Freezing the aqueous solution may separate fibers within the fiber tow.", "The aqueous solution may be freeze dried.", "The freeze drying may remove the water from the mold.", "The mold may be processed via at least one of slurry casting, chemical vapor infiltration, polymer infiltration and pyrolysis, or melt infiltration.", "In various embodiments, the carbon nanotubes may form an interfacial region surrounding the fibers.", "The method may further comprise converting the carbon nanotubes to at least one of boron carbide or boron nitride nanotubes.", "The method may further comprise converting the carbon nanotubes to silicon carbide nanotubes.", "The freezing may comprise at least one of inserting the mold in a freezer, cooling the mold with liquid nitrogen, or cooling the mold with dry ice.", "The carbon nanotubes and the fiber tow may form a rigid preform.", "The method may further comprise pyrolyzing the binder to carbon and converting the carbon to at least one of silicon carbide or boron carbide.", "A ceramic matrix composite may be formed by a process comprising inserting a fiber tow in a mold.", "An aqueous solution comprising water, carbon nanotubes, and a binder may be introduced into the mold.", "The aqueous solution may be frozen.", "Freezing the aqueous solution may separate fibers within the fiber tow.", "The aqueous solution may be freeze dried.", "The freeze drying may remove the water from the mold.", "The mold may be processed via at least one of slurry cast, chemical vapor infiltration, polymer infiltration and pyrolysis, or melt infiltration.", "In various embodiments, the process may comprise converting the carbon nanotubes to at least one of boron carbide or boron nitride nanotubes.", "The process may further comprise converting the carbon nanotubes to silicon carbide nanotubes.", "The carbon nanotubes may be bonded to the fibers.", "The carbon nanotubes may form an interfacial region surrounding the fibers.", "The foregoing features and elements may be combined in various combinations without exclusivity, unless expressly indicated otherwise.", "These features and elements as well as the operation thereof will become more apparent in light of the following description and the accompanying drawings.", "It should be understood, however, the following description and drawings are intended to be exemplary in nature and non-limiting." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a divisional application of U.S. patent application Ser.", "No.", "14/838,856, filed Aug. 28, 2015, entitled “SYSTEMS AND METHODS FOR CERAMIC MATRIX COMPOSITES,” which claims priority to, and the benefit of U.S.", "Provisional Application No.", "62/046,368, entitled “SYSTEMS AND METHODS FOR CERAMIC MATRIX COMPOSITES,” filed on Sep. 5, 2014.The entire content of each of these applications is hereby incorporated by reference in its entirety.", "FIELD The disclosure relates generally to composite materials, and more specifically to methods for forming ceramic matrix composites.", "BACKGROUND Fiber-reinforced ceramic matrix composites (“CMCs”) can exhibit exceptional high temperature properties such as high strength, modulus, and toughness.", "These properties result from the incorporation of high strength fibers into a stable atrix.", "The high strength fibers may have a coating which creates a weak interface between the fibers and the matrix material.", "The fibers are typically incorporated into the composite in fiber tows, which are bundles of individual fiber filaments.", "Each fiber tow may remain as a discrete entity during CMC processing as opposed to having the individual fiber filaments being distributed uniformly throughout the composite.", "The weak interface between the fibers and the matrix material enables debonding of the fibers from the matrix, allowing for crack deflection, bridging and enhanced material strength and toughness.", "SUMMARY A method for fabricating a composite material may comprise adding a slurry to a fiber preform comprising a plurality of fiber tows.", "The slurry may be intermixed with carbon nanotubes.", "The method may comprise freezing the fiber preform.", "The method may comprise freeze drying the fiber preform.", "In various embodiments, the freezing the fiber preform may separate fibers in the plurality of fiber tows.", "The slurry may comprise a binder.", "The method may comprise heat treating the fiber preform.", "The heat treating may comprise converting the carbon nanotubes to at least one of boron carbide or boron nitride nanotubes.", "The heat treating may comprise converting the carbon nanotubes to silicon carbide nanotubes.", "The carbon nanotubes may bond to fibers in the fiber tows.", "The method may comprise processing the fiber preform via at least one of slurry casting, chemical vapor infiltration, polymer infiltration and pyrolysis, or melt infiltration.", "A method of manufacturing an aircraft component may comprise inserting a fiber tow in a mold.", "An aqueous solution comprising water, carbon nanotubes, and a binder may be introduced into the mold.", "The aqueous solution may be frozen.", "Freezing the aqueous solution may separate fibers within the fiber tow.", "The aqueous solution may be freeze dried.", "The freeze drying may remove the water from the mold.", "The mold may be processed via at least one of slurry casting, chemical vapor infiltration, polymer infiltration and pyrolysis, or melt infiltration.", "In various embodiments, the carbon nanotubes may form an interfacial region surrounding the fibers.", "The method may further comprise converting the carbon nanotubes to at least one of boron carbide or boron nitride nanotubes.", "The method may further comprise converting the carbon nanotubes to silicon carbide nanotubes.", "The freezing may comprise at least one of inserting the mold in a freezer, cooling the mold with liquid nitrogen, or cooling the mold with dry ice.", "The carbon nanotubes and the fiber tow may form a rigid preform.", "The method may further comprise pyrolyzing the binder to carbon and converting the carbon to at least one of silicon carbide or boron carbide.", "A ceramic matrix composite may be formed by a process comprising inserting a fiber tow in a mold.", "An aqueous solution comprising water, carbon nanotubes, and a binder may be introduced into the mold.", "The aqueous solution may be frozen.", "Freezing the aqueous solution may separate fibers within the fiber tow.", "The aqueous solution may be freeze dried.", "The freeze drying may remove the water from the mold.", "The mold may be processed via at least one of slurry cast, chemical vapor infiltration, polymer infiltration and pyrolysis, or melt infiltration.", "In various embodiments, the process may comprise converting the carbon nanotubes to at least one of boron carbide or boron nitride nanotubes.", "The process may further comprise converting the carbon nanotubes to silicon carbide nanotubes.", "The carbon nanotubes may be bonded to the fibers.", "The carbon nanotubes may form an interfacial region surrounding the fibers.", "The foregoing features and elements may be combined in various combinations without exclusivity, unless expressly indicated otherwise.", "These features and elements as well as the operation thereof will become more apparent in light of the following description and the accompanying drawings.", "It should be understood, however, the following description and drawings are intended to be exemplary in nature and non-limiting.", "BRIEF DESCRIPTION OF THE DRAWINGS The subject matter of the present disclosure is particularly pointed out and distinctly claimed in the concluding portion of the specification.", "A more complete understanding of the present disclosure, however, may best be obtained by referring to the detailed description and claims when considered in connection with the drawing figures.", "FIG.", "1 illustrates a fiber preform in accordance with various embodiments; FIG.", "2 illustrates a fiber preform in a slurry in accordance with various embodiments; FIG.", "3 illustrates a fiber tow in a slurry in accordance with various embodiments; FIG.", "4 illustrates a fiber tow in a frozen slurry in accordance with various embodiments; FIG.", "5 illustrates a freeze dried fiber tow in accordance with various embodiments; and FIG.", "6 illustrates a flowchart of a process for fabricating a ceramic matrix composite in accordance with various embodiments.", "DETAILED DESCRIPTION The detailed description of various embodiments herein makes reference to the accompanying drawings, which show various embodiments by way of illustration.", "While these various embodiments are described in sufficient detail to enable those skilled in the art to practice the disclosure, it should be understood that other embodiments may be realized and that logical, chemical, and mechanical changes may be made without departing from the spirit and scope of the disclosure.", "Thus, the detailed description herein is presented for purposes of illustration only and not of limitation.", "For example, the steps recited in any of the method or process descriptions may be executed in any order and are not necessarily limited to the order presented.", "Furthermore, any reference to singular includes plural embodiments, and any reference to more than one component or step may include a singular embodiment or step.", "Also, any reference to attached, fixed, connected, or the like may include permanent, removable, temporary, partial, full, and/or any other possible attachment option.", "Additionally, any reference to without contact (or similar phrases) may also include reduced contact or minimal contact.", "Methods for forming ceramic matrix composites (“CMCs”) with enhanced fiber distribution are disclosed herein.", "The CMCs may comprise increased uniformity of fiber distribution throughout the CMC.", "A fiber preform may be provided.", "The fiber preform may comprise a plurality of fiber tows.", "An aqueous solution may be introduced into the fiber preform.", "The aqueous solution may be intermixed with carbon nanotubes.", "The aqueous solution may freeze, spreading apart the individual fibers in the fiber tows by virtue of expansion associated with freezing.", "The water in the aqueous solution may be removed via a freeze drying process.", "After the removal of water, the carbon nanotubes may remain in place.", "The carbon nanotubes may be converted to boron carbide, boron nitride, or silicon carbide nanotubes via heat treatment in the presence of a precursor, such as a boron-bearing precursor.", "Standard CMC processing methods may be used to finish the CMC fabrication.", "Referring to FIG.", "1, a fiber preform 100 is illustrated according to various embodiments.", "A plurality of fiber tows 110 may be placed in a mold 120.In various embodiments, the fiber tows 110 may be aligned in a tape, and layers of tape may be stacked in order to fill the mold 120.Each fiber tow 110 may comprise a plurality of individual fibers.", "The fibers may comprise any material typically used in CMC processing, such as polyacrylonitrile (“PAN”) fibers, carbon, alumina, silicon carbide, zirconia, boron carbide, glass, or mullite.", "In various embodiments, the fibers may comprise a weak interface coating, which allows the fibers to slide with respect to a matrix material.", "However, in various embodiments the fibers may be bare fibers, wherein the fibers do not comprise a weak interface coating or any interface coating.", "Referring to FIG.", "2, the fiber preform 100 is illustrated with a slurry 230 introduced to the mold 120 and surrounding fiber tows 110.The slurry may comprise an aqueous solution comprising water, carbon nanotubes, binders, or any other suitable organic or inorganic additives.", "Binders may include polyvinyl alcohol (“PVA”), polyvinylpyrrolidone (“PVP”), polyethylenimine (“PEI”), cellulosic binders, phenolic resins, acrylics, or any other suitable binders.", "Referring to FIG.", "3, an enlarged view of a fiber tow 110 in the slurry 230 is illustrated according to various embodiments.", "The carbon nanotubes 310 in the slurry 230 may be distributed throughout the slurry and between the individual fibers 312 in the fiber tow 110.The binders in the slurry may bond the carbon nanotubes 310 to the fibers 312.The fiber preform may be frozen, and the slurry 230 and carbon nanotubes 310 may freeze in place.", "The fiber preform may be frozen by a variety of methods, including being placed in a freezer, or being chilled by liquid nitrogen or dry ice.", "Referring to FIG.", "4, an enlarged view of a fiber tow 110 in the frozen slurry 230 is illustrated according to various embodiments.", "During the freezing process, the water in the slurry 230 may expand.", "This expansion may spread apart the individual fibers 312.The spreading of the fibers 312 may more uniformly distribute the fibers 312 throughout the mold.", "This may improve the properties of the final component, as the fibers 312 will provide strength more uniformly throughout the composite, as opposed to having regions in between tows comprising primarily matrix material.", "The mold may be freeze dried in order to remove the water from the mold.", "Referring to FIG.", "5, an enlarged view of a fiber tow 110 after freeze drying is illustrated according to various embodiments.", "The freeze drying may remove the water.", "However, the carbon nanotubes 310 may remain coupled to the fibers 312.The carbon nanotubes 310 may form an entangled network of nanotubes throughout the fiber tow 110.The carbon nanotubes 310 may form a rigid structure which prevents the fibers 312 from moving back together.", "The carbon nanotubes 310 and fiber tows 110 may form a rigidized preform.", "Additionally, as the carbon nanotubes 310 are distributed in multiple orientations, the carbon nanotubes 310 may provide multi-directional strength to the final composite structure.", "In various embodiments, the fibers may comprise an interface coating.", "A rigidized preform may be processed via standard CMC processing methods, such as a slurry cast method, chemical vapor infiltration, melt infiltration, polymer infiltration and pyrolysis, or combinations thereof, with the carbon nanotubes 310 providing and enhanced interfacial region.", "However, in various embodiments, the carbon nanotubes 310 may be further processed to create an interfacial zone surrounding the fibers 312 which creates a weak bond with the matrix material.", "The rigidized preform may be heated to a temperature of between 1230° C.-1800° C. (2240° F.-3300° F.) under vacuum or inert atmosphere in a furnace containing a silicon oxide bearing precursor.", "The carbon nanotubes 310 may react with the silicon oxide bearing precursor and be converted to silicon carbide nanotubes.", "In various embodiments, the rigidized preform may be heated to a temperature of between 1300° C.-1800° C. (2400° F.-3300° F.) in the presence of a boron-bearing precursor under a nitrogen-containing or combined vacuum and nitrogen-containing atmosphere.", "The carbon nanotubes 310 may be converted to boron carbide, silicon carbide, or boron nitride nanotubes.", "In either heat treating process, the organic or inorganic binders or additives may be converted to a more desirable composition.", "For example, the organic binders may be pyrolzyed to carbon and converted to silicon carbide or boron carbide.", "After the heat treatment, the rigidized preform may be processed using standard CMC processes.", "Referring to FIG.", "6, a flowchart of a process 600 for fabricating a CMC is illustrated according to various embodiments.", "A fiber preform comprising a plurality of fiber tows may be inserted in a mold (step 610).", "A slurry comprising an aqueous solution and carbon nanotubes may be inserted in the mold (step 620).", "The fiber preform may be frozen (step 630).", "Freezing the fiber preform may spread apart the individual fibers in the fiber tows.", "The fiber preform may be freeze dried (step 640).", "Freeze drying the fiber preform may remove the liquid from the fiber preform.", "The carbon nanotubes may be fixed in place and coupled to the individual fibers.", "The fiber preform may be heat treated in the presence of a boron-bearing precursor or a silicon oxide bearing precursor (step 650).", "In various embodiments, the carbon nanotubes may be converted to boron carbide, silicon carbide or boron nitride nanotubes.", "In various embodiments, the carbon nanotubes may be converted to silicon carbide nanotubes.", "The rigidized preform may be processed according to standard CMC processes to form the CMC (step 660).", "In various embodiments, standard CMC processes may include at least one of slurry casting, chemical vapor infiltration, polymer infiltration and pyrolysis, or melt infiltration.", "The CMCs described herein may be particularly well-suited to high temperature applications.", "For example, a CMC component may be used in an aircraft, such as for a turbine blade, a turbine vane, a blade outer air seal, a combustor liner, or a brake disk.", "Although primarily described with reference to CMCs, the processes and products disclosed herein are also compatible with organic matrix composites (“OMCs”).", "Carbon nanotubes and other nanofibers may benefit the out-of-plane properties of OMCs.", "Benefits, other advantages, and solutions to problems have been described herein with regard to specific embodiments.", "Furthermore, the connecting lines shown in the various figures contained herein are intended to represent exemplary functional relationships and/or physical couplings between the various elements.", "It should be noted that many alternative or additional functional relationships or physical connections may be present in a practical system.", "However, the benefits, advantages, solutions to problems, and any elements that may cause any benefit, advantage, or solution to occur or become more pronounced are not to be construed as critical, required, or essential features or elements of the disclosure.", "The scope of the disclosure is accordingly to be limited by nothing other than the appended claims, in which reference to an element in the singular is not intended to mean “one and only one” unless explicitly so stated, but rather “one or more.” Moreover, where a phrase similar to “at least one of A, B, or C” is used in the claims, it is intended that the phrase be interpreted to mean that A alone may be present in an embodiment, B alone may be present in an embodiment, C alone may be present in an embodiment, or that any combination of the elements A, B and C may be present in a single embodiment; for example, A and B, A and C, B and C. or A and B and C. Different cross-hatching is used throughout the figures to denote different parts but not necessarily to denote the same or different materials.", "Systems, methods and apparatus are provided herein.", "In the detailed description herein, references to “one embodiment”, “an embodiment”, “various embodiments”, etc., indicate that the embodiment described may include a particular feature, structure, or characteristic, but every embodiment may not necessarily include the particular feature, structure, or characteristic.", "Moreover, such phrases are not necessarily referring to the same embodiment.", "Further, when a particular feature, structure, or characteristic is described in connection with an embodiment, it is submitted that it is within the knowledge of one skilled in the art to affect such feature, structure, or characteristic in connection with other embodiments whether or not explicitly described.", "After reading the description, it will be apparent to one skilled in the relevant art(s) how to implement the disclosure in alternative embodiments.", "Furthermore, no element, component, or method step in the present disclosure is intended to be dedicated to the public regardless of whether the element, component, or method step is explicitly recited in the claims.", "No claim element herein is to be construed under the provisions of 35 U.S.C.", "112(f) unless the element is expressly recited using the phrase “means for.” As used herein, the terms “comprises”, “comprising”, or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus." ] ]
Patent_15874284
[ [ "COLD PRESSURE FIX TONER COMPOSITIONS BASED ON SMALL MOLECULE CRYSTALLINE AND AMORPHOUS ORGANIC COMPOUND MIXTURES", "A cold pressure fix toner composition includes at least one C16 to C80 crystalline organic material having a melting point in a range from about 30° C. to about 130° C. and at least one C16 to C80 amorphous organic material having a Tg of from about −30° C. to about 70° C. A method of cold pressure fix toner application includes providing the cold pressure fix toner composition, disposing the cold pressure fix toner composition on a substrate and applying pressure to the disposed composition on the substrate under cold pressure fixing conditions.", "The cold pressure fix toner compositions can be formed into latexes." ], [ "1.A latex formed from a cold pressure fix toner composition comprising: at least one C16 to C80 crystalline organic material having a melting point in a range from about 30° C. to about 130° C.; and at least one C16 to C80 amorphous organic material having a Tg of from about −30° C. to about 70° C. 2.The latex of claim 1, wherein the at least one crystalline organic material comprises a polyester, or a small molecule ester selected from a phenyl ester or a benzyl ester.", "3.The latex of claim 1, wherein the at least one crystalline organic material comprises a small molecule ester selected from the group consisting of and mixtures thereof.", "4.The latex of claim 1, wherein the small molecule ester is selected from the group consisting of and mixtures thereof.", "5.The latex of claim 1, wherein the number average molecular weight Mn of the crystalline organic material is from about 300 to about 1200, and a weight average molecular weight Mw is from about 300 to about 2,000.6.The latex of claim 1, wherein the at least one amorphous organic material is an optionally hydrogenated rosin ester or a modified rosin ester.", "7.The latex of claim 6, wherein the optionally hydrogenated rosin ester or the modified rosin ester comprises a mono-, di-, or tri-tetra-ester.", "8.The latex of claim 1, wherein the at least one amorphous material is selected from the group consisting of styrenated terpenes, polyterpenes, terpene phenolics, and mixtures thereof.", "9.The latex of claim 1, wherein the at least one amorphous material is an optionally hydrogenated hydrocarbon resin based on aliphatic C5 monomers or aromatic C9 monomers.", "10.The latex of claim 1, wherein the number average molecular weight Mn of the amorphous organic material is from about 300 to about 1200, and the weight average molecular weight Mw is from about 300 to about 2,000.11.The latex of claim 1, wherein the amorphous organic material having an acid number of about 0 to about 300.12.The latex of claim 1, further comprising an acid functionality on the at least one crystalline organic material, and/or the at least one amorphous organic material.", "13.The latex of claim 9, wherein the acid functionality is incorporated as a monoester of a diacid.", "14.The latex of claim 1, wherein the weight ratio of the crystalline organic material to the amorphous organic material is from about 50:50 to about 95:5.15.The latex of claim 1, wherein the temperature required to lower viscosity to 104 Pa-s of the cold pressure fix toner at a pressure of 100 kgf/cm2 is from about 15° C. to about 70° C. 16.The latex of claim 1, wherein the temperature required to lower viscosity of the cold pressure fix toner to about 104 Pa-s at a pressure of 10 kgf/cm2 is from about 50° C. to 90° C. 17.The latex of claim 1, wherein the temperature shift from 10 to 100 kgf/cm2 of the cold pressure fix toner to lower the viscosity to 104 Pa-s is in a range from about 10° C. to about 60° C. 18.The latex of claim 1, prepared by phase inversion emulsification.", "19.A latex formed from a cold pressure fix toner composition comprising: a crystalline organic material comprising: (1) a polyester; or (2) a small molecule ester selected from a phenyl ester, or a benzyl ester; wherein the crystalline organic material has a melting point in a range from about 30° C. to about 130° C.; and an amorphous organic material comprising: (a) a rosin ester; (b) styrenated terpenes, polyterpenes, or terpene phenolics; or (c) a hydrogenated hydrocarbon resin derive from a 5 carbon aliphatic monomer or 9 carbon aromatic monomer; wherein the amorphous organic material having a Tg of from about −30° C. to about 70° C., and the number average molecular weight Mn of the amorphous organic material is from about 300 to about 1200, and the weight average molecular weight Mw is from about 300 to about 2,000.20.A latex formed from a cold pressure fix toner composition comprising: a crystalline organic material comprising: (1) a polyester; or (2) a small molecule ester selected from a distearyl terephthalate (DST), a phenyl ester, or a benzyl ester; wherein the crystalline organic material has a melting point in a range from about 30° C. to about 130° C.; and an amorphous organic material comprising: (a) a rosin ester; (b) styrenated terpenes, polyterpenes, or terpene phenolics; or (c) a hydrogenated hydrocarbon resin derive from a 5 carbon aliphatic monomer or 9 carbon aromatic monomer; wherein the amorphous organic material having a Tg of from about −30° C. to about 70° C., and the number average molecular weight Mn of the amorphous organic material is from about 300 to about 1200, and the weight average molecular weight Mw is from about 300 to about 2,000; further wherein the temperature required to lower viscosity to 104 Pa-s of the cold pressure fix toner at a pressure of 100 kgf/cm2 is from about 15° C. to about 70° C., and wherein the temperature required to lower viscosity of the cold pressure fix toner to about 104 Pa-s at a pressure of 10 kgf/cm2 is from about 50° C. to 90° C., and wherein the temperature shift from 10 to 100 kgf/cm2 of the cold pressure fix toner to lower the viscosity to 104 Pa-s is in a range from about 10° C. to about 60° C." ], [ "<SOH> BACKGROUND <EOH>The present disclosure relates to toner compositions for use in xerography.", "In particular, the present disclosure relates to cold pressure fix toner compositions.", "Cold pressure fix toners normally operate in a system employing a pair of high-pressure rollers to fix toner to paper without heating.", "Among the advantages of such systems are the use of low power and little paper heating.", "One example of a cold pressure fix toner comprises predominantly wax an ethylene-vinyl acetate copolymer with softening point of 99° C., and a 120° C. softening point polyamide thermoplastic polymer.", "An example of this approach is shown in U.S. Pat.", "No.", "4,935,324, which is incorporated herein by reference.", "Another example of a cold pressure fix toner is comprised of a copolymer of styrene with 1-tertiary-butyl-2-ethenyl benzene and a polyolefin wax exemplified for example as Xerox 4060 cold pressure fix toner.", "Other cold fix toners have been based on a long chain acrylate core produced by suspension polymerization, such as lauryl acrylate.", "Examples of such compositions are disclosed in U.S. Pat.", "Nos.", "5,013,630 and 5,023,159 which are incorporated herein by reference.", "Such systems are designed to have a core with a T g less than room temperature.", "A hard shell, such as polyurethane prepared by an interfacial polymerization, is disposed about the core in order to keep the liquid content in the core in the toner particle.", "Performance issues in designs with high wax content include that they work only at high pressure, such as about 2000 psi or even 4000 psi, which are respectively, 140 kgf/cm 2 and 280 kgf/cm 2 and even then image robustness can be poor.", "In the case of long chain acrylate core designs the shell needs to be very thin to break under pressure, but it can be very challenging to prevent the capsules from leaking because the core is typically a liquid at room temperature." ], [ "<SOH> SUMMARY <EOH>In some aspects, embodiments herein relate to cold pressure fix toner compositions comprising at least one C16 to C80 crystalline organic material having a melting point in a range from about 30° C. to about 130° C. and at least one C16 to C80 amorphous organic material having a Tg of from about −30° C. to about 70° C. In other aspects, embodiments herein relate to methods of cold pressure fix toner application comprising providing a cold pressure fix toner composition comprising at least one C16 to C80 crystalline organic material having a melting point in a range from about 30° C. to about 130° C. and at least one C16 to C80 amorphous organic material ester having a Tg of from about 0° C. to about 60° C., disposing the cold pressure fix toner composition on a substrate and applying pressure to the disposed composition on the substrate under cold pressure fixing conditions.", "In still further aspects, embodiment herein relate to latexes formed from a cold pressure fix toner composition comprising at least one C16 to C80 crystalline amorphous material having a melting point in a range from about 30° C. to about 130° C.; and at least one C16 to C80 amorphous rosin ester having a Tg of from about −30° C. to about 60° C." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a divisional application of co-pending U.S. patent application Ser.", "No.", "14/802,949, filed Jul.", "17, 2015, which is herein incorporated by reference in its entirety.", "BACKGROUND The present disclosure relates to toner compositions for use in xerography.", "In particular, the present disclosure relates to cold pressure fix toner compositions.", "Cold pressure fix toners normally operate in a system employing a pair of high-pressure rollers to fix toner to paper without heating.", "Among the advantages of such systems are the use of low power and little paper heating.", "One example of a cold pressure fix toner comprises predominantly wax an ethylene-vinyl acetate copolymer with softening point of 99° C., and a 120° C. softening point polyamide thermoplastic polymer.", "An example of this approach is shown in U.S. Pat.", "No.", "4,935,324, which is incorporated herein by reference.", "Another example of a cold pressure fix toner is comprised of a copolymer of styrene with 1-tertiary-butyl-2-ethenyl benzene and a polyolefin wax exemplified for example as Xerox 4060 cold pressure fix toner.", "Other cold fix toners have been based on a long chain acrylate core produced by suspension polymerization, such as lauryl acrylate.", "Examples of such compositions are disclosed in U.S. Pat.", "Nos.", "5,013,630 and 5,023,159 which are incorporated herein by reference.", "Such systems are designed to have a core with a Tg less than room temperature.", "A hard shell, such as polyurethane prepared by an interfacial polymerization, is disposed about the core in order to keep the liquid content in the core in the toner particle.", "Performance issues in designs with high wax content include that they work only at high pressure, such as about 2000 psi or even 4000 psi, which are respectively, 140 kgf/cm2 and 280 kgf/cm2 and even then image robustness can be poor.", "In the case of long chain acrylate core designs the shell needs to be very thin to break under pressure, but it can be very challenging to prevent the capsules from leaking because the core is typically a liquid at room temperature.", "SUMMARY In some aspects, embodiments herein relate to cold pressure fix toner compositions comprising at least one C16 to C80 crystalline organic material having a melting point in a range from about 30° C. to about 130° C. and at least one C16 to C80 amorphous organic material having a Tg of from about −30° C. to about 70° C. In other aspects, embodiments herein relate to methods of cold pressure fix toner application comprising providing a cold pressure fix toner composition comprising at least one C16 to C80 crystalline organic material having a melting point in a range from about 30° C. to about 130° C. and at least one C16 to C80 amorphous organic material ester having a Tg of from about 0° C. to about 60° C., disposing the cold pressure fix toner composition on a substrate and applying pressure to the disposed composition on the substrate under cold pressure fixing conditions.", "In still further aspects, embodiment herein relate to latexes formed from a cold pressure fix toner composition comprising at least one C16 to C80 crystalline amorphous material having a melting point in a range from about 30° C. to about 130° C.; and at least one C16 to C80 amorphous rosin ester having a Tg of from about −30° C. to about 60° C. BRIEF DESCRIPTION OF DRAWINGS Various embodiments of the present disclosure will be described herein below with reference to the figures wherein: FIG.", "1 shows the Shimadzu flow tester viscosity with temperature plot for an exemplary mixture of a crystalline ester distearyl terephthalate and an amorphous polyterpene resin SYLVARES™ TR A25 in a 79/21 wt % ratio for cold pressure fix application.", "At low pressure of 10 kgf/cm2 the transition temperature to reach a viscosity of 104 Pa-s is 77° C., while at a high pressure of 100 kgf/cm2 the transition temperature to reach a viscosity of 104 Pa-s is 38° C. The shift in the transition temperature to reach a viscosity of 104 Pa-s is 39° C. between a pressure of 10 kgf/cm2 and 100 kgf/cm2 FIG.", "2A shows the Shimadzu flow tester transition temperatures for an exemplary mixture of a crystalline ester distearyl terephthalate with varying amorphous Tg for different amorphous small molecule organic materials at a 79/21 wt % ratio.", "Shown are transitions temperatures to reach 104 Pa-s at 10 kgf/cm2, at 100 kgf/cm2 and the difference in the transition temperatures to reach 104 Pa-s at 10 kgf/cm2 minus that at 100 kgf/cm2.FIG.", "2B shows a plot with the same materials as FIG.", "2A and transition temperatures as in FIG.", "1, but showing the effect of different Ts of the different amorphous small molecules.", "FIG.", "3 shows the Shimadzu results for an exemplary mixture of a crystalline polyester polymer with an amorphous small molecule polyterpene resin SYLVARES™TR A25 in 79/21 wt % ratio.", "DETAILED DESCRIPTION Embodiments herein provide cold pressure fix toners that comprise at least one crystalline organic compound which may be a small molecule or organic polymer, either of which is coupled with at least one amorphous organic small molecule or organic oligomeric resin.", "The crystalline and amorphous components are mixed together to provide a material that undergoes a phase change from solid to liquid at modest temperature, such as about 20° C. to about 70° C. at a pressure as low as 25 kgf/cm2 to about 100 kgf/cm2 to about 400 kgf/cm2.In embodiments there are provided cold pressure fix toners that comprise at least one crystalline small molecule, such as a crystalline small molecule ester for example, and at least one amorphous organic molecule or resin composition, or in embodiments at least one amorphous organic small molecule or organic oligomeric resin composition.", "The crystalline and amorphous small molecules are mixed together to provide a material that undergoes a phase change from solid to liquid at modest temperature, such as about 20° C. to about 70° C. at a pressure as low as 25 kgf/cm2 to about 100 kgf/cm2 to about 400 kgf/cm2.In some embodiments, the cold pressure fix toners may comprise a solid ink design employed in solid inkjet printing.", "While solid inkjet inks typically operate by heating above 100° C., it has been surprisingly found that under pressure these materials exhibit desirable flow near room temperature, and thus are ideal for cold pressure fix toner applications.", "In embodiments there are provided cold pressure fix toners that comprise at least one crystalline polyester resin and at least one amorphous organic small molecule or organic oligomeric resin composition.", "The crystalline polyester resin and amorphous small molecules are mixed together to provide a material that undergoes a phase change from solid to liquid at modest temperature, such as about 20° C. to about 70° C. at a pressure as low as 25 kgf/cm2 to about 100 kgf/cm2 to about 400 kgf/cm2.As used herein, a “small molecule” or oligomeric resin has less than about 80 carbon atoms and less than about 100 carbon and oxygen atoms combined.", "In embodiments, there are provided cold pressure fix toner compositions comprising at least one crystalline organic material, such as a crystalline ester or crystalline polyester, having a melting point in a range from about 30° C. to about 130° C. and at least one C16 to C80 amorphous small molecule or oligomeric resin having a Tg of from about −30° C. to about 70° C. In embodiments, there are provided cold pressure fix toner compositions comprising at least one C16 to C80 crystalline organic material, such as a crystalline ester, having a melting point in a range from about 30° C. to about 130° C. and at least one amorphous molecule or resin having a Tg of from about −30° C. to about 70° C., or in embodiments at least one C16 to C80 amorphous small molecule or oligomeric resin having a Tg of from about −30° C. to about 70° C. As used herein, “small molecule” refers to an organic compound, i.e., one containing at least carbon and hydrogen atoms, and having a molecule weight less than 2,000 daltons, or less than 1,500 daltons, or less than 1,000 daltons, or less than 500 daltons.", "As used herein, “cold pressure fix toner” or “CPF toner” refers to a toner material designed for application to a substrate and which is affixed to the substrate primarily by application of pressure.", "While heating may be optionally employed to assist in fixing a CPF toner, one benefit of the compositions disclosed herein is the ability to used reduced heating, or in embodiments, no applied heating.", "Affixing by application of pressure may be achieved in a broad range of pressures, such as from about 50 kgf/cm2 to about 100 kgf/cm2 to about 200 kgf/cm2.If necessary it is possible to use higher pressures up to about 400 kgf/cm2, however, generally such higher pressures are undesirable, causing calendaring and even wrinkling of the paper which distorts the look and feel of the paper, and requires more robust pressure fix rolls and spring assemblies.", "In embodiments, the CPF toner comprises at least one crystalline ester.", "In some such embodiments, the CPF toner comprises a crystalline diester.", "In embodiments, the at least one crystalline ester comprises an optionally substituted phenyl or benzyl ester.", "In embodiments, the at least one crystalline ester comprises distearyl terephthalate (DST).", "In embodiments, suitable crystalline esters may be diesters from about C16 to C80, with melting points in a range from about 30° C. to about 130° C., such as those shown in the examples below in Table 1.In embodiments, it may be desirable to incorporate one or more acid groups, such as carboxylate or sulfonate, in these materials to provide negative charge to enhance toner performance.", "These acid groups may also be useful so the materials may be employed in the emulsion/aggregation toner processing.", "In embodiments, the acid moiety may be disposed in any position on the aromatic residues of the compounds in Table 1.In other embodiments, the acid may be provided by including some amount of monoester in place of the diester so that one end of the molecule bears an acid moiety.", "TABLE 1 Tmelt Tcrys Tg Structure (° C.) (° C.) (° C.) 94 47 n/a 115 62 n/a 74 ~50 n/a 102 51 n/a 86 34 n/a 35 n/a n/a 127 75 n/a 59 20-26 n/a 100 62 n/a 56 −5 n/a 119 ~75 n/a 80 18 n/a 80, 83 63 n/a 71 21 n/a 87 ~50 n/a 69 42 n/a 58 3 n/a 88 79 n/a 95 82 n/a 110 83 n/a In embodiments, the crystalline compound is a di-ester compounds made from Scheme 1 below.", "wherein R is a saturated or ethylenically unsaturated aliphatic group in one embodiment with at least about 6 carbon atoms, and in another embodiment with at least about 8 carbon atoms, and in one embodiment with no more than about 100 carbon atoms, in another embodiment with no more than about 80 carbon atoms, and in yet another embodiment with no more than about 60 carbon atoms, although the number of carbon atoms can be outside of these ranges, In a specific embodiment, the crystalline compound is derived from natural fatty alcohols such as octanol, stearyl alcohol, lauryl alcohol, behenyl alcohol, myristyl alcohol, capric alcohol, linoleyl alcohol, and the like.", "The above reaction may be conducted by combining dimethyl terepthalate and alcohol in the melt in the presence of a tin catalyst, such as, dibutyl tin dilaurate (Fascat 4202), dibutyl tin oxide (Fascat 4100); a zinc catalyst, such as Bi cat Z; or a bismuth catalyst, such as Bi cat 8124; Bi cat 8108, a titanium catalyst such as titanium dioxide.", "Only trace quantities of catalyst are required for the process.", "In embodiments, the catalyst is present in an amount of about 0.01 weight percent to 2 weight percent or of about 0.05 weight percent to about 1 weight percent of the total product.", "The reaction can be carried out at an elevated temperature of about 150° C. to about 250° C. or from about 160° C. to about 210° C. The solvent-free process is environmentally sustainable and eliminates problems with byproducts and also means higher reactor throughput.", "In embodiments, the crystalline component may have a structure of Formula A: wherein p1 is from about 1 to about 40, and q1 is from about 1 to about 40.In certain embodiments, p1 is from about 8 to about 26, from about 14 to about 20, or from about 16 to about 18.In certain embodiments, q1 is from about 8 to about 26, from about 14 to about 20, or from about 16 to about 18.In certain embodiments, p1 is the same as q1.In embodiments, the crystalline component is present in an amount of from about 50 percent to about 95 percent by weight, from about 60 percent to about 95 percent by weight, or from about 65 percent to about 95 percent by weight, or from about 70 percent to about 90 percent by weight of the total weight of the CPF toner composition.", "Typically, the weight ratio of the crystalline component to the amorphous component is from about 50:50 to about 95:5, or is from about 60:40 to about 95:5, or is from about 70:30 to about 90:10.In embodiments, the crystalline component is a polyester resin.", "Crystalline polyester resins can be prepared from a diacid and a diol.", "Examples of organic diols selected for the preparation of crystalline polyester resins include aliphatic diols with from about 2 to about 36 carbon atoms, such as 1,2-ethanediol, 1,3-propanediol, 1,4-butanediol, 1,5-pentanediol, 1,6-hexanediol, 1,7-heptanediol, 1,8-octanediol, 1,9-nonanediol, 1,10-decanediol, 1,12-dodecanediol, and the like; alkali sulfo-aliphatic diols such as sodio 2-sulfo-1,2-ethanediol, lithio 2-sulfo-1,2-ethanediol, potassio 2-sulfo-1,2-ethanediol, sodio 2-sulfo-1,3-propanediol, lithio 2-sulfo-1,3-propanediol, potassio 2-sulfo-1,3-propanediol, mixture thereof, and the like.", "The aliphatic diol is, for example, selected in an amount of from about 45 to about 50 mole percent of the resin, and the alkali sulfo-aliphatic diol can be selected in an amount of from about 1 to about 10 mole percent of the resin.", "Examples of organic diacids or diesters selected for the preparation of the crystalline polyester resins include oxalic acid, succinic acid, glutaric acid, adipic acid, suberic acid, azelaic acid, sebacic acid, phthalic acid, isophthalic acid, terephthalic acid, napthalene-2,6-dicarboxylic acid, naphthalene-2,7-dicarboxylic acid, cyclohexane dicarboxylic acid, malonic acid and mesaconic acid, a diester or anhydride thereof; and an alkali sulfo-organic diacid such as the sodio, lithio or potassium salt of dimethyl-5-sulfo-isophthalate, dialkyl-5-sulfo-isophthalate-4-sulfo-1,8-naphthalic anhydride, 4-sulfo-phthalic acid, dimethyl-4-sulfo-phthalate, dialkyl-4-sulfo-phthalate, 4-sulfophenyl-3,5-dicarbomethoxybenzene, 6-sulfo-2-naphthyl-3,5-dicarbometh-oxybenzene, sulfo-terephthalic acid, dimethyl-sulfo-terephthalate, 5-sulfo-isophthalic acid, dialkyl-sulfo-terephthalate, sulfo-p-hydroxybenzoic acid, N,N-bis(2-hydroxyethyl)-2-amino ethane sulfonate, or mixtures thereof.", "The organic diacid may be selected in an amount of, for example, from about 40 to about 50 mole percent of the resin, and the alkali sulfoaliphatic diacid can be selected in an amount of from about 1 to about 10 mole percent of the resin.", "As an example, crystalline resins 1,12-dodecanedioic acid has been prepared with diols from C3 (1,3-propylene glycol), to C12, (1,12-dodecanediol), to yield crystalline polyesters with a Tm from about 60° C. to about 90° C. The properties of crystalline polyesters used in connection with embodiments herein are shown in Table 2 below.", "TABLE 2 Tm GPC AV (° C.) g/m × 1000 Resin ID Acid:Diol Mg KOH/g 1st Mw Mn A C12:C9 10.3 71.0 24.2 6.8 B C12:C6 14.5 72.3 14.3 6.1 C C12:C3 17 66.1 13.4 6.6 Toners for cold pressure fix comprised of a mixture of a crystalline polyester resin with a melting point of about 30° C. to about 90° C., and at least one amorphous mono-, di-, tri- and tetra-ester, including rosin esters, based on glycercol, propylene glycol, dipropylene glycol, tartaric acid, citric acid or pentaerythritol, or a terpene oligomer, with from about 16 to about 80 carbons, and with a Tg of from about 0° C. to about 40° C. In embodiments, the crystalline polyester may have an acid value of about 6 to about 30, an Mn of about 1,000 to about 10,000, and an Mw of about 2,000 to about 30,000.Toners could be prepared by any means, including conventional extrusion and grinding, suspension, SPSS, incorporated in an N-Cap toner, incorporated in an EA toner, optionally with a shell.", "Latexes can be prepared, by, but are not limited to, solvent flash or phase inversion emulsification, including by solvent free methods.", "In embodiments, the cold pressure fix toner composition comprises at least one rosinated or rosin ester which may be a mono-, di-, tri-tetra-ester based on an alcohol such as methanol, glycercol (1,2,3-trihydroxypropane), diethylene glycol, ethylene glycol, propylene glycol, dipropylene glycol, menthol, neopentylglycol, pentaerythritol (2,2-bis(hydroxymethyl)1,3-propanediol), phenol, tertiary butyl phenol, and an acid such as tartaric acid, citric acid, oxalic acid, succinic acid, glutaric acid, adipic acid, suberic acid, azelaic acid, fumaric acid, maleic acid, dodecanedioic acid, and sebacic acid.", "Suitable rosinated esters, without limitation, include those with about 16 to about 80 carbon atoms, including those with an number average molecular weight Mn of about 300 to about 1200, and a weight average molecular weight Mw of about 300 to about 2000.Suitable rosinated esters, without limitation, have an acid number of about 0 to about 300.Optionally monoesters, including monoesters with some acid functionality can be incorporated, including rosin acids, with an acid value of about 30 to about 400.As used herein, a “rosinated ester” or “rosin ester” synonymously refers to rosin acids that have been esterified.", "Such rosin acids may include naturally occurring resinous acids exuded by various species of trees, primarily pine and other conifers.", "The rosin may be separated from the essential oil spirit of turpentine by distillation.", "Tall oil rosin is produced during the distillation of crude tall oil, a by-product of the kraft paper making process.", "Additionally, the “stump waste” from pine trees can be distilled or extracted with solvent to separate out rosin, which is called wood rosin.", "The rosin utilized in the rosin ester may be partially or totally hydrogenated to remove some or essentially all the double bonds in the rosin, which results in a lighter color and significantly improved stability or the rosin and rosin ester.", "As an example abietic acid can be partially dehyrogenated to form dihydroabietic acid, or full dehydrogenated to form tetrahydroabietic acid.", "Again, it may be desirable to incorporate some acid groups in the cold fix toner materials in the amorphous component to provide a negative charge for toner performance and emulsion/aggregation toner processing.", "For such purposes some amount of the amorphous material that had a free acid end, rather than terminated by an ester, can be used.", "Alternatively, some of the ester groups might be replaced by ester groups that further include acid functionality.", "Suitable rosin esters that are available commercially include ABALYN® a rosin methyl ester, PENTALYN® A a rosin pentaerythritol ester, PEXALYN® 9085 a rosin glycerol ester, PEXALYN® T a rosin pentaerythritol ester, PINOVA® Ester Gum 8BG a rosin glycerol ester, FORAL® 85 a hyrogentated rosin glycerol ester, FORAL® 105 a pentaerythritol ester of hydroabietic (rosin) acid, FORAL® 3085 a hydrogenated rosin glycerol ester, HERCOLYN® D a hydrogenated rosin methyl ester, PENTALYN® H a rosin pentaerythritol ester, all available commercially from Pinova; ARAKAWA® Ester Gum G, ARAKAWA® Ester Gum AA-L, ARAKAWA® Ester Gum AAV ARAKAWA® Ester Gum AT rosin esters commercially available from Arakawa Chemical Industries, Ltd.; ARAKAWA® Ester Gum HP, ARAKAWA® Ester Gum H, ARAKAWA® Ester Gum HT hydrogenated rosin esters commercially available from Arakawa Chemical Industries, Ltd.; ARAKAWA® S-80, ARAKAWA® S-100, ARAKAWA® S-115, ARAKAWA® A-75, ARAKAWA® A-100, ARAKAWA® A-115, ARAKAWA® A-125, ARAKAWA® L, ARAKAWA-18 stabilized rosin esters commercially available from Arakawa Chemical Industries, Ltd.; ARAKAWA® KE-311 and KE-100 resins, triglycerides of hydrogenated abietic (rosin) acid commercially available from Arakawa Chemical Industries, Ltd.; ARAKAWA® KE-359 a hydrogenated rosin ester and ARAKAWA® D-6011 a disproportionated rosin ester commercially available from Arakawa Chemical Industries, Ltd.; and SYLVALITE® RE 10L, SYLVALITE® RE 80HP, SYLVALITE® RE 85L, SYLVALITE® RE 100XL, SYLVALITE® RE 100L, SYLVALITE® RE 105L, SYLVALITE® RE 110L.", "SYLVATAC® RE 25, SYLVATAC® RE 40, SYLVATAC® RE 85, SYLVATAC® RE 98 all available from Arizona Chemical; and PERMALYN™ 5095 a rosin glycerol ester, PERMALYN™ 5095-C a rosin glycerol ester, PERMALYN™ 5110 a rosin pentaerythritol ester, PERMALYN™ 5110-C, a rosin pentaerythritol ester, PERMALYN™ 6110 a rosin pentaerythritol ester, PERMALYN™ 6110-M a rosin pentaerythritol ester, PERMALYN™ 8120 a rosin pentaerythritol ester, STAYBELITE™ Ester 3-E a partially hydrogenated rosin ester, STAYBELITE™ Ester 5-E a partially hydrogenated rosin ester, and STAYBELITE™ Ester 10-E a partially hydrogenated rosin ester all available from Eastman Kodak; and ARAKAWA® ESTER E-720 and SUPER ESTER E-730-55 rosin ester latexes commercially available from Arakawa Chemical Industries, Ltd. Table 3 below shows examples of other amorphous esters suitable for cold pressure fix toners disclosed herein.", "TABLE 3 Tmelt Tcrys Structure (° C.) (° C.) Tg (° C.) n/a n/a 6 n/a n/a 11-16 n/a n/a 5 Other suitable small molecule amorphous materials include other modified rosins, and are not limited to rosin esters.", "Examples of other suitable small molecule amorphous modified rosins include UNI-TAC® 70 available commercially from Arizona Chemicals, and ABITOL™ E a Hydroabietyl alcohol available commercially from Eastman Kodak; and POLY-PALE™ a dimerized rosin available commercially from Eastman Kodak.", "Other suitable small molecule amorphous materials include terpene resins, such as resins from α-pinene, including PICCOLYTE® A25, PICCOLYTE® A115, and PICCOLYTE® A125 from Pinova; and resins from β-pinene, PICCOLYTE®S25, PICCOLYTE® S85, PICCOLYTE® S115, and PICCOLYTE® S125 from Pinova; and resins from d-limonene, including PICCOLYTE® C85, PICCOLYTE® C105, PICCOLYTE® C115, PICCOLYTE® C115, PICCOLYTE® D115 from Pinova; and resins from mixed terpenes, such as PICCOLYTE® F105 IG and PICCOLYTE® F115 IG from Pinova; and other terpene based resins including SYLVARES® TR A25, SYLVARES® TR B115, SYLVARES® TR 7115, SYLVARES® TR 7125, SYLVAGUM® TR 90, SYLVAGUM® TR 105, ZONATAC® NG 98 a styrene modified terpene resin from Arizona Chemicals; and synthetic polyterpene resins such as NEVTAC® 2300, NEVTAC® 100, and NEVTAC® 80 commercially available from Neville Chemical Company; and PICCOLYTE® HM106 Ultra a styrenated polyterpene resin of d-limonene from Pinova; and hydrogenated terpene resins such as CLEARON® P115, CLEARON® P105, CLEARON® P85 from Yasuhara Chemical Co., Ltd.; Hydrogenated Aromatic Modified Terpene Resin such as CLEARON®M115, CLEARON® M105, CLEARON® K100, CLEARON® K4100, Aromatic Modified Terpene Polymer YS Resin TO115, YS Resin TO105, YS Resin TO85, YS Resin TR105 from Yasuhara Chemical Co., Ltd.; and Terpene phenolic resins, including YS Polyster U130, YS Polyster U115, YS Polyster T115, YS Polyster T100, YS Polyster T80 all from Yasuhara Chemical Co., Ltd., and SYLVARES® TP 96, SYLVARES® TP 300, SYLVARES® TP 2040, SYLVARES® TP 2019, SYLVARES® TP 2040HM, SYLVARES® TP 105, SYLVARES® TP 115 from Arizona chemicals.", "Other suitable small molecule amorphous materials include rosin acids, including but not limited to FORAL® AX a thermoplastic, acidic resin produced by hydrogenating wood rosin and FORAL® NC synthetic resin is the partial sodium resinate of the highly hydrogenated wood rosin, FORAL® AX, both available commercially from Pinova; and ARAKAWA® KE-604, ARAKAWA® KE-604B, ARAKAWA® KR-610, ARAKAWA® KR-612, and ARAKAWA® KR-614 hydrogenated rosins available commercially from Arakawa Chemical Industries, Ltd. Other suitable small molecule amorphous materials include the class of materials known as tackifiers, in which category many of the amorphous materials herein are typically included.", "Other tackifiers are also known, and may be suitable as the small molecule amorphous material used herein, or may be added in effective amounts of up to about 40%.", "Examples of other potentially effective tackifiers include aliphatic C5 monomer resin, PICCOTAC™ 1095, hydrogenated C5 monomer resin EASTOTAC™ H-100R, EASTOTAC™ H-100L Resin, EASTOTAC™ H-100W Resin, C9 monomer resins KRISTALEX™ 1120, PICCOTEX™ 75, PICCOTEX™ LC, PICCOTEX™ 100 Hydrocarbon Resin, styrenic C8 monomers resins PICCOLASTIC™ A5, PICCOLASTIC™ A75, hydrogenated, C9 aromatic monomer resins REGALITE™ S1100, partially hydrogenated, C9 aromatic monomer resins REGALITE™ S5100, REGALITE™ S7125, REGALITE™ R1100, REGALITE™ R7100, REGALITE™ R1090, REGALITE™ R1125, REGALITE™ R9100, mixed C5 aliphatic and C9 aromatic monomer resins PICCOTAC™ 8095, PICCOTAC™ 9095, PICCOTAC™ 7050, aromatic hydrocarbon resins, REGALREZ™ 1094, hydrogenated C9 monomer aromatic hydrocarbon resins, REGALREZ™ 1085, partially hydrogenated, C9 aromatic monomer resin REGALREZ™ all from Eastman; Aliphatic C5 modified petroleum resin WINGTACK® 10, WINGTACK® 95, WINGTACK® 98, WINGTACK® 86, aromatically modified petroleum resin WINGTACK® ET and aromatically modified petroleum resin WINGTACK® STS all from Cray Valley.", "In the cold pressure fix toner composition, an acid functionality may be present on the at least one crystalline ester, the at least one amorphous rosinated ester, or both.", "In some such embodiments, the acid functionality is incorporated as a monoester of a diacid.", "In other embodiments, the acid functionality is incorporated as a separate functional group present on the at least one crystalline ester.", "In yet other embodiments, the acid functionality is incorporated as a separate functional group present on the at least one amorphous rosinated ester.", "In embodiments, an amorphous small molecule component may have an acid value of about 0 to about 30.In embodiments the temperature for the viscosity of the material to be reduced to a value of about 10,000 Pa-s at about 100 kgf/cm2 applied pressure, is from about 0° C. to about 50° C., in other embodiments about 10° C. to about 40° C., in further embodiments from about 0° C. to about 30° C. In other embodiments the applied pressure for toner materials flow is from about 25 to about 400 kgf/cm2, and in further embodiments from about 50 to about 200 kgf/cm2.For cold pressure fixable toner it may be desirable to have the toner material flow near room temperature under the applied pressure of the cold pressure fixing system, to enable the toner to flow over the substrate surface and into pores or fibers in the substrate, as well as to enable the toner particles to flow into each other, thus providing a smooth continuous toner layer that is effectively adhered to the substrate.", "It may be desirable that the pressure applied be relatively low compared to the prior art, such as about 100 kgf/cm2.However, in embodiments the pressure can be higher, up to about 400 kgf/cm2, or lower, as little as 25 kgf/cm2, provided that the above described conditions for onset of toner flow and flow viscosity can be met.", "In embodiments, some heat may be applied to preheat the toner or the paper prior to entry to the cold pressure fixing system, which can enable cold pressure fix for temperatures somewhat above room temperature.", "In embodiments, it may be desirable for cold pressure fix that under low pressures, such as about 10 kgf/cm2 applied pressure the cold pressure fix toner does not flow significantly such that the toner particles stick together, for example in the toner cartridge, or in the printer, including in the developer housing, or on the imaging surfaces such as the photoreceptor, or in embodiments the intermediate transfer belt.", "In shipping or in the printer the temperature may rise to as much as 50° C., thus in embodiments it may be desirable that the toner does not flow significantly to allow the particles stick together up to 50° C. at about 10 kgf/cm2.Thus, in embodiments the temperature for the viscosity of the material to be reduced to a value of about 10,000 Pa-s, for the cold pressure fix toner at a lower pressure of about 10 kgf/cm2 applied pressure, is from about 50° C. to about 70° C., in embodiments about 55° C. to about 70° C., in embodiments about 60° C. to about 90° C., or in further embodiments at about 20 kgf/cm2 to about 40 kgf/cm2.Thus it may be desirable to have a high temperature for material flow at low pressures representative of storage and usage in the printer, and a low temperature for material at the desired higher cold pressure fix pressure.", "In embodiments there is a temperature shift calculated in the range from about 10° C. to about 60° C. where the flow viscosity of the cold pressure fix composition equal to about 10,000 pascal-seconds, when the applied pressure on the cold pressure fix composition is increased from 10 to 100 Kgf/cm2.In such embodiments, the temperature shift can be calculated as, ΔTη=0000=Tη=10000(10 Kgf/Cm2)−Tη=10000(100 Kgf/Cm2) where Tη=10000(10 kgf/cm2) is the temperature for flow viscosity n of 10000 Pa-s at 10 kgf/cm2 applied pressure and Tη=10000(100 kgf/cm2) is the temperature for flow viscosity η of 10000 Pa-s at 100 kgf/cm2.In other embodiments the low pressure for storage and printer usage applied can be in the range of about 10 kgf/cm2 to about 40 kgf/cm2, and the high pressure for applied for cold pressure fix can be in the range of about 25 kgf/cm2 to about 400 kgf/cm2.In embodiments, there are provided methods of cold pressure fix toner application comprising providing a cold pressure fix toner composition comprising: at least one crystalline material and one small molecule amorphous material C16 to C80 crystalline ester having a melting point in a range from about 30° C. to about 130° C. and at least one amorphous ester having a Tg of from about −30° C. to about 70° C., disposing the cold pressure fix toner composition on a substrate, and applying pressure to the disposed composition on the substrate under cold pressure fixing conditions.", "In some embodiments, the applied pressure is in a range from about 25 kgf/cm2 to about 400 kgf/cm2.In embodiments, cold pressure fix is accomplished by applying pressure in the aforementioned range between two fixing rolls that may be selected from known fixing rolls, such as in U.S. Pat.", "No.", "8,541,153 herein incorporated by reference.", "Examples of the fixing rolls are cylindrical metal rolls, which optionally may be coated with fluorine containing resins such as TEFLON® PTFE polytetrafluoroethylene resins, TEFLON® PFA perfluoroalkoxy resins, TEFLON® FEP a fluorinated ethylene propylene, DUPONT™ TEFLON® AF amorphous fluoroplastic resins, and silicon resins, or a combination of the different resins.", "The two fixing rolls may be made of the same materials or may be different.", "In embodiments the fixing step is cold pressure fix without any direct application of heat in the fixing step.", "However, due to the heat from the printer components, frictional heating between the rolls, the temperature may be elevated above room temperature in the fusing nip.", "In addition, the paper and or toner layer on the paper in embodiments may be heated for example with a heat lamp prior to the cold pressure fix apparatus.", "In embodiments, there are provided latexes formed from a cold pressure fix toner composition comprising at least one C16 to C60 crystalline ester having a melting point in a range from about 30° C. to about 130° C. and at least one C16 to C80 amorphous rosinated ester having a Tg of from about 0° C. to about 60° C. Toners can be prepared from the cold press toner compositions disclosed herein by any means, including conventional extrusion and grinding, suspension, SPSS (Spherical Polyester Toner by Suspension of Polymer/Pigment Solution and Solvent Removal Method, as described in Journal of the Imaging Society of Japan, Vol.", "43, 1, 48-53, 2004), incorporated in an N-Cap toner, (encapsulated toner, as described for example in U.S. Pat.", "No.", "5,283,153 and incorporated in an emulsion aggregation toner, optionally with a shell.", "Where needed for toner applications, latexes can be made incorporating the crystalline and/or amorphous mixtures, prepared by solvent flash, by phase inversion emulsification, including by solvent free methods.", "Other additives may be present in the CPF toners disclosed here.", "The CPF toner compositions of the present embodiments may further optionally include one or more conventional additives to take advantage of the known functionality associated with such conventional additives.", "Such additives may include, for example, colorants, antioxidants, defoamer, slip and leveling agents, clarifier, viscosity modifier, adhesive, plasticizer and the like.", "When present, the optional additives may each, or in combination, be present in the CPF toner in any desired or effective amount, such as from about 1% to about 10%, from about 5% to about 10%, or from about 3% to about 5% by weight of the CPF toner.", "In a typical CPF toner composition antioxidants are added for preventing discoloration of the small molecule composition.", "In embodiments, the antioxidant material can include IRGANOX® 1010; and NAUGARD® 76, NAUGARD® 445, NAUGARD® 512, and NAUGARD® 524.In embodiments, the antioxidant is NAUGARD® 445.In other embodiments the antioxidant material can include MAYZO® BNX® 1425 a calcium salt of phosphonic acid, and MAYZO® BNX® 358 a thiophenol both available commercially from MAYZO®, and ETHANOX® 323A a nonylphenol disulfide available commercially from SI Group.", "In embodiments, CPF toners disclosed herein may further comprise a plasticizer.", "Exemplary plasticizers may include Uniplex 250 (commercially available from Unitex), the phthalate ester plasticizers commercially available from Ferro under the trade name SANTICIZER®, such as dioctyl phthalate, diundecyl phthalate, alkylbenzyl phthalate (SANTICIZER® 278), triphenyl phosphate (commercially available from Ferro), KP-140, a tributoxyethyl phosphate (commercially available from Great Lakes Chemical Corporation), MORFLEX® 150, a dicyclohexyl phthalate (commercially available from Morflex Chemical Company Inc.), trioctyl trimellitate (commercially available from Sigma Aldrich Co.), and the like.", "Plasticizers may be present in an amount from about 0.01 to about 30 percent, from about 0.1 to about 25 percent, from about 1 to about 20 percent by weight of the CPF toner.", "In embodiments, the cold pressure fix toner compositions described herein also include a colorant.", "Any desired or effective colorant can be employed in the cold pressure fix toner compositions, including dyes, pigments, mixtures thereof.", "Any dye or pigment may be chosen, provided that it is capable of being dispersed or dissolved in the CPF toner and is compatible with the other CPF toner components.", "Any conventional cold pressure fix toner colorant materials, such as Color Index (C.I.)", "Solvent Dyes, Disperse Dyes, modified Acid and Direct Dyes, Basic Dyes, Sulphur Dyes, Vat Dyes, fluorescent dyes and the like.", "Examples of suitable dyes include NEOZAPON® Red 492 (BASF); ORASOL® Red G (Pylam Products); Direct Brilliant Pink B (Oriental Giant Dyes); Direct Red 3BL (Classic Dyestuffs); SUPRANOL® Brilliant Red 3BW (Bayer AG); Lemon Yellow 6G (United Chemie); Light Fast Yellow 3G (Shaanxi); Aizen Spilon Yellow C-GNH (Hodogaya Chemical); Bemachrome Yellow GD Sub (Classic Dyestuffs); CARTASOL® Brilliant Yellow 4GF (Clariant); Cibanone Yellow 2G (Classic Dyestuffs); ORASOL® Black RLI (BASF); ORASOL® Black CN (Pylam Products); Savinyl Black RLSN (Clariant); Pyrazol Black BG (Clariant); MORFAST® Black 101 (Rohm & Haas); Diaazol Black RN (ICI); THERMOPLAST® Blue 670 (BASF); ORASOL® Blue GN (Pylam Products); Savinyl Blue GLS (Clariant); LUXOL® Fast Blue MBSN (Pylam Products); Sevron Blue 5GMF (Classic Dyestuffs); BASACID® Blue 750 (BASF); KEYPLAST® Blue (Keystone Aniline Corporation); NEOZAPON® Black X51 (BASF); Classic Solvent Black 7 (Classic Dyestuffs); SUDAN® Blue 670 (C.I.", "61554) (BASF); SUDAN® Yellow 146 (C.I.", "12700) (BASF); SUDAN® Red 462 (C.I.", "26050) (BASF); C.I.", "Disperse Yellow 238; Neptune Red Base NB543 (BASF, C.I.", "Solvent Red 49); Neopen Blue FF-4012 (BASF); Fatsol Black BR (C.I.", "Solvent Black 35) (Chemische Fabriek Triade BV); Morton Morplas Magenta 36 (C.I.", "Solvent Red 172); metal phthalocyanine colorants such as those disclosed in U.S. Pat.", "No.", "6,221,137, the disclosure of which is totally incorporated herein by reference, and the like.", "Polymeric dyes can also be used, such as those disclosed in, for example, U.S. Pat.", "No.", "5,621,022 and U.S. Pat.", "No.", "5,231,135, the disclosures of each of which are herein entirely incorporated herein by reference, and commercially available from, for example, Milliken & Company as Milliken Ink Yellow 869, Milliken Ink Blue 92, Milliken Ink Red 357, Milliken Ink Yellow 1800, Milliken Ink Black 8915-67, uncut Reactint Orange X-38, uncut Reactint Blue X-17, Solvent Yellow 162, Acid Red 52, Solvent Blue 44, and uncut Reactint Violet X-80.Pigments are also suitable colorants for the cold pressure fix toners.", "Examples of suitable pigments include PALIOGEN® Violet 5100 (BASF); PALIOGEN® Violet 5890 (BASF); HELIOGEN® Green L8730 (BASF); LITHOL® Scarlet D3700 (BASE); SUNFAST® Blue 15:4 (Sun Chemical); HOSTAPERM® Blue B2G-D (Clariant); HOSTAPERM® Blue B4G (Clariant); Permanent Red P-F7RK; HOSTAPERM® Violet BL (Clariant); LITHOL® Scarlet 4440 (BASF); Bon Red C (Dominion Color Company); ORACET® Pink RF (BASF); PALIOGEN® Red 3871 K (BASF); SUNFAST® Blue 15:3 (Sun Chemical); PALIOGEN® Red 3340 (BASF); SUNFAST® Carbazole Violet 23 (Sun Chemical); LITHOL® Fast Scarlet L4300 (BASF); SUNBRITE® Yellow 17 (Sun Chemical); HELIOGEN® Blue L6900, L7020 (BASF); SUNBRITE® Yellow 74 (Sun Chemical); SPECTRA PAC C Orange 16 (Sun Chemical); HELIOGEN® Blue K6902, K6910 (BASF); SUNFAST® Magenta 122 (Sun Chemical); HELIOGEN® Blue D6840, D7080 (BASF); SUDAN® Blue OS (BASF); NEOPEN Blue FF4012 (BASF); PV Fast Blue B2GO1 (Clariant); IRGALITE Blue GLO (BASF); PALIOGEN® Blue 6470 (BASF); SUDAN® Orange G (Aldrich); SUDAN® Orange 220 (BASF); PALIOGEN® Orange 3040 (BASF); PALIOGEN® Yellow 152, 1560 (BASF); LITHOL® Fast Yellow 0991 K (BASF); PALIOTOL Yellow 1840 (BASF); NOVOPERM Yellow FGL (Clariant); Ink Jet Yellow 4G VP2532 (Clariant); Toner Yellow HG (Clariant); Lumogen Yellow D0790 (BASF); Suco-Yellow L1250 (BASF); Suco-Yellow D1355 (BASF); Suco Fast Yellow D1355, D1351 (BASF); HOSTAPERM Pink E 02 (Clariant); Hansa Brilliant Yellow 5GX03 (Clariant); Permanent Yellow GRL 02 (Clariant); Permanent Rubine L6B 05 (Clariant); FANAL Pink D4830 (BASF); CINQUASIA® Magenta (DU PONT); PALIOGEN® Black L0084 (BASF); Pigment Black K801 (BASF); and carbon blacks such as REGAL 330™ (Cabot), Nipex 150 (Evonik) Carbon Black 5250 and Carbon Black 5750 (Columbia Chemical), and the like, as well as mixtures thereof.", "Pigment dispersions in the CPF toner may be stabilized by synergists and dispersants.", "Generally, suitable pigments may be organic materials or inorganic.", "Magnetic material-based pigments are also suitable, for example, for the fabrication of robust Magnetic Ink Character Recognition (MICR) inks.", "Magnetic pigments include magnetic nanoparticles, such as for example, ferromagnetic nanoparticles.", "Also suitable are the colorants disclosed in U.S. Pat.", "No.", "6,472,523, U.S. Pat.", "No.", "6,726,755, U.S. Pat.", "No.", "6,476,219, U.S. Pat.", "No.", "6,576,747, U.S. Pat.", "No.", "6,713,614, U.S. Pat.", "No.", "6,663,703, U.S. Pat.", "No.", "6,755,902, U.S. Pat.", "No.", "6,590,082, U.S. Pat.", "No.", "6,696,552, U.S. Pat.", "No.", "6,576,748, U.S. Pat.", "No.", "6,646,111, U.S. Pat.", "No.", "6,673,139, U.S. Pat.", "No.", "6,958,406, U.S. Pat.", "No.", "6,821,327, U.S. Pat.", "No.", "7,053,227, U.S. Pat.", "No.", "7,381,831 and U.S. Pat.", "No.", "7,427,323, the disclosures of each of which are incorporated herein by reference in their entirety.", "In embodiments, solvent dyes are employed.", "An example of a solvent dye suitable for use herein may include spirit soluble dyes because of their compatibility with the CPF toner carriers disclosed herein.", "Examples of suitable spirit solvent dyes include NEOZAPON® Red 492 (BASF); ORASOL® Red G (Pylam Products); Direct Brilliant Pink B (Global Colors); Aizen Spilon Red C-BH (Hodogaya Chemical); Kayanol Red 3BL (Nippon Kayaku); Spirit Fast Yellow 3G; Aizen Spilon Yellow C-GNH (Hodogaya Chemical); CARTASOL® Brilliant Yellow 4GF (Clariant); PERGASOL® Yellow 5RA EX (Classic Dyestuffs); ORASOL® Black RLI (BASF); ORASOL® Blue GN (Pylam Products); Savinyl Black RLS (Clariant); MORFAST® Black 101 (Rohm and Haas); THERMOPLAST® Blue 670 (BASF); Savinyl Blue GLS (Sandoz); LUXOL® Fast Blue MBSN (Pylam); Sevron Blue 5GMF (Classic Dyestuffs); BASACID® Blue 750 (BASF); KEYPLAST® Blue (Keystone Aniline Corporation); NEOZAPON® Black X51 (C.I.", "Solvent Black, C.I.", "12195) (BASF); SUDAN® Blue 670 (C.I.", "61554) (BASF); SUDAN® Yellow 146 (C.I.", "12700) (BASF); SUDAN® Red 462 (C.I.", "260501) (BASF), mixtures thereof and the like.", "The colorant may be present in the cold pressure fix toner in any desired or effective amount to obtain the desired color or hue such as, for example, at least from about 0.1 percent by weight of the CPF toner to about 50 percent by weight of the CPF toner, at least from about 0.2 percent by weight of the CPF toner to about 20 percent by weight of the CPF toner, and at least from about 0.5 percent by weight of the CPF toner to about 10 percent by weight of the CPF toner.", "The colorant may be included in the CPF toner in an amount of from, for example, about 0.1 to about 15% by weight of the CPF toner, or from about 0.5 to about 6% by weight of the CPF toner.", "The following Examples are being submitted to illustrate embodiments of the present disclosure.", "These Examples are intended to be illustrative only and are not intended to limit the scope of the present disclosure.", "Also, parts and percentages are by weight unless otherwise indicated.", "As used herein, “room temperature” refers to a temperature of from about 20° C. to about 25° C. EXAMPLES Example 1-C16 to C80 Crystalline Organic Material This example describes testing of exemplary cold pressure fix toners in accordance with embodiments herein.", "Shimadzu flow tester evaluation of cold pressure fix capability: In order to test the ability of materials to flow under pressure, as required by cold pressure fix, a Shimadzu Flow tester also known as a Capillary Rheometer (available from Shimadzu Scientific Instruments) was used.", "Solid samples were either scalloped away or cracked into pieces with a rubber mallet.", "Samples were neither dried nor ground.", "All materials were pressed into a slug with 5000 pounds of pressure and a 10 second hold.", "The samples were run on a Shimadzu CFT 500/100 tester.", "All samples were extruded through a 1.0×1.0 mm cone die using a piston with a cross sectional area of 1 cm2.Typical sample weights were between about 1.5 g and 2.5 grams.", "The process conditions were: about 23 to 26° C. to begin, 10 Kg or 100 Kg, 180 second pre-heat and a ramp rate of 3° C./minute.", "Thus, the two pressures tested were 10 kgf/cm2 as a control at low pressure, and 100 Kgf/cm2 as a high pressure, the latter high pressure representative of the target pressure for cold pressure fix.", "Table 4 below shows the compositions and Shimadzu results for two control toners.", "TABLE 4 Transition Temperature (° C., 104 Pa-s) ΔT (° C.) Sample Polymer formulation 100 kgf/cm2 10 kgf/cm2 10-100 kgf/cm2 Control 1 50:50 copolymer of styrene 113 123 10 And 1-t-butyl-2-ethenyl benzene Control 2 46:46:8 ratio of 100 100 0 amorphous resin A:amorphous resin B:crystalline resin C Control 1 is an example of a cold pressure fix toner which is comprised of a copolymer of styrene withl-tertiary-butyl-2-ethenyl benzene and a polyolefin wax, the Xerox 4060 cold pressure fix toner.", "Table 4 shows that the Control 1 toner cold pressure fix toner flow, the transition from high to low viscosity at about 104 Pa-s, occurs about 10° C. lower at high pressure than at low pressure, and even at high pressure has a flow transition temperature of over 100° C. Note Control 1 is designed to fix at about 300 kgf/cm2, about 3× higher than applied here.", "But clearly is not suitable for cold pressure fix at 100 kgf/cm2.Control 2 is a black emulsion/aggregation toner of particle size of about 5.7 μm comprised of a core of about 25% each of polyester A and polyester B, about 8% of crystalline polyester C, about 10% polyethylene wax, about 6% carbon black and 1% cyan pigment, and a shell of about 14% each of polyester A and polyester B, where polyester A has an average molecular weight (Mw) of about 86,000, a number average molecular weight (Mn) of about 5,600, and an onset glass transition temperature (Tg onset) of about 56° C., where polyester B has a Mw of about 19,400, an Mn of about 5,000, a Tg onset of about 60° C., and where the crystalline polyester resin C has an Mw of about 23,300, an Mn of about 10,500, and a melting temperature (Tm) of about 71° C., wherein the polyethylene wax has a Tm of about 90° C. Both amorphous resins were of the formula wherein m is from about 5 to about 1000.The crystalline resin was of the formula wherein n is from about 5 to about 2000.As shown in Table 4 Control 2 toner, which is a mixture of crystalline and amorphous polymer resins, has no difference in rheology with pressure at all, and also has a very high transition temperature of 100° C. to low viscosity, thus is not itself a candidate for cold pressure fix at this pressure.", "Table 5 shows the compositions and results for samples with small molecule amorphous and crystalline materials.", "TABLE 5 Transition Crystalline small Amorphous small Temperature ΔT molecule molecule Amorphous properties (° C., 104 Pa-s) (° C.) Sample Structure wt % Structure wt % Tg (° C.) Ts (° C.) Mn Mw AV 100 kgf/cm2 10 kgf/cm2 10 − 100 kgf/cm2 1 Distearyl 100 none NA NA NA NA NA 78 83 5 terephthalate 2 Ester (II) 70 Benzoate ester 30 NA NA NA NA NA 54 69 15 mixture (III) 3 Distearyl 79 SYLVATAC ® 21 5 35 850 1275 14 45 75 30 terephthalate RE40 rosin ester 4 Distearyl 79 SYLVARES ™ 21 −20 25 330 462 0 38 77 39 terephthalate TR A25 polyterpene 5 Distearyl 79 SYLVALITE ® 21 39 85 810 1053 10 60 80 20 terephthalate RE 85L rosin ester 6 Distearyl 79 SYLVARES ™ 21 47 95 520 676 0 63 78 15 terephthalate TP 96 polyterpene phenolic 7 Distearyl 79 Uni-Tac 70 21 45 80 315 756 140 61 78 17 terephthalate modified rosin 8 Distearyl 79 Arakawa Ester 21 34 68 no no 10 55 79 24 terephthalate Gum H data data hydrogenated rosin ester 9 Distearyl 70 SYLVARES ™ 30 −20 25 330 462 0 30 65 35 10 terephthalate 60 TR A25 40 −20 25 330 462 0 27 59 32 polyterpene 11 Distearyl 79 SYLVALITE□ 21 −20 liquid 680 748 10 35 81 46 12 terephthalate 70 RE 10L rosin 30 −20 liquid 680 748 10 26 73 47 13 60 ester 40 −20 liquid 680 748 10 26 77 51 Sample 1 is comprised of distearyl terephthalate, or DST, the diester (I): Sample 2 is comprised primarily of a 70:30 weight ratio of a crystalline diester (II) with an amorphous short chain oligomer mixture comprised of an amide and an ester in the main chain, terminated as benzoate esters (Ill).", "Sample 3 has a 79:21 ratio of the crystalline distearyl terephthalate (DST; compound (I)) and SYLVATAC® RE40 an amorphous mixture of rosinated esters (IV), the main component a diester of diethylene glycol, and minor components of a monoester of diethylene glycol, and di-, tri- and tetra-esters of pentaerythritol.", "The Standard cold press fix toner (Control 1 in Table 4) has a transition temperature for 104 Pa-s at about 113° C. which is too high in temperature to be useful for cold pressure fix, and a shift of 10° C. with high pressure.", "The resin-based toner (Control 2) with crystalline and amorphous polyester resins has no temperature shift with pressure and thus is not suitable as major components for cold pressure fix.", "The designs using crystalline/amorphous mixtures of small molecule esters, such as Sample 2 solid ink and in particular Sample 3 solid ink (Table 5) are suitable cold press fix materials.", "Sample 3, in particular, has a larger shift with pressure as the Standard cold press fix toner (Control 1), but with a much lower transition temperature that is approaching room temperature.", "Thus, Samples 1 and 3 represent an advantage over currently employed cold press fix toners.", "Example 2-Crystalline Polyester Flow tester evaluation of cold pressure fix capability: To test the ability of the materials to flow under pressure for cold pressure fix (CPF), a Shimadzu flow tester was used.", "Solid samples were either scalloped away or cracked into pieces with a rubber mallet.", "All materials were pressed into a slug with 5,000 pounds of pressure and a 10 second hold.", "The samples were run on a Shimadzu CFT 500/100 tester.", "All samples were extruded through a 1.0×1.0 mm cone die using a piston with a cross sectional area of 1 cm2.The process conditions were: 27.7° C. to begin, either 10 Kg or 100 Kg, 180 second pre-heat and a ramp rate of 3° C./minute.", "Thus, the two pressures tested were 10 kgf/cm2 and 100 kgf/cm2.The latter is a particularly useful target pressure for CPF.", "Results are tabulated in Table 6.Useful designs generally have a transition temperature to reach a viscosity of 104 Pa-s, of about 0° C. to 50° C. at 100 kgf/cm2 to enable room temperature fusing, and a of about 55° C. to 70° C. at low pressure, for good toner blocking.", "Example 1 uses a crystalline small molecule, distearyl terephthalate, and an amorphous small molecule, SYLVARES™ TR A25, a small molecule oligomeric alpha-pinene.", "The high pressure onset temperature of this material in Example 1 was about 38° C., just above room temperature, while the transition at low pressure is still high enough at about 73° C. to potentially provide reasonable blocking.", "By contrast, in the present Example which is a mixture of crystalline C12:C9 diacid:diol (CPE) resin and amorphous resins, instead of crystalline and amorphous small molecules, there was no perceived shift with pressure, and thus there is a very high transition temperature at high pressure.", "The CPE polyester resin alone also does not show any shift with pressure and thus has a very high transition temperature at high pressure.", "Also note that the CPE low pressure transition temperature is about 73° C., close to the CPE melt point, but when an amorphous resin with Tg of about 55° C. to 60° C. is added, the transition temperature actually increases.", "Thus, unexpectedly a CPF toner based on a mixture of these amorphous and crystalline polyester resins is not suitable for CPF.", "It was therefore very surprising that the same C12:C9 CPE resin mixed with the SYLVARES™ TR A25 (a small molecule oligomeric alpha pinene resin) shifted the transition temperature to lower temperature of about 54° C. at high pressure, a temperature shift of 15° C. The CPE with diol chain lengths of C3 and C6 also has a similar high pressure transition of about 54° C. The low pressure transition was in all cases very close to the melt point of the CPE.", "So in all cases at low pressure these would all pass blocking criterion, while providing a much lower transition at high pressure than the control material.", "TABLE 6 Phase Change Transition Crystalline Temperature, Tpc (° C.) Material Properties @1 × 104 Pa-s Melt point Tpc Tpc ΔTpc Sample Comment (° C.) Mw Mn @100 kgf/cm2 @10 kgf/cm2 (10 kgf/cm2 − 100 kgf/cm2) 1 79% DST/21% 72.5 15.7 6.5 38 73 35 SYLVARES ™ TR A25 (from Example 1) 2 46:46:8 wt % ratio of 7 22.9 10.4 100 100 0 amorphous resin A:amorphous resin B:crystalline resin C C12:C9 qcid; diol CPE (from Example 1) 3 C12:C9 acid:diol 71 22.9 10.4 73 73 0 CPE 4 79:21 63 13.4 6.6 54 63 9 C12:C3/SYLVARES ™ TR A25 5 79:21 72 14.3 6.1 53 70 17 C12:C6/SYLVARES ™ TR A25 6 79:21 71 22.9 10.4 54 69 15 C12:C9/SYLVARES ™ TR A25 7 70:30 72 15.7 6.5 45 70 25 C12:C6/SYLVARES ™ TR A25 8 60:40 72 15.7 6.5 37 70 33 C12:C6/SYLVARES ™ TR A25 9 50:50 72 15.7 6.5 29 64 35 C12:C6/SYLVARES ™ TR A25 10 70:30 72.6 16.9 7.6 45 62 17 C12:C6/SYLVATAC ® RE 25 11 70:30 72.6 16.9 7.6 40 63 23 C12:C6/SYLVALITE□ RE 10L 12 70:30 72.7 17.0 7.5 26 57 31 C12:C6/SYLVALITE ® RE 10L As shown in samples 7 to sample 12 increasing the amount of amorphous small molecule lowers the high pressure transition temperature further.", "The low pressure transition is not greatly affected by the addition of amorphous resin, the transition temperature at low pressure remains close to the CPE melt-point, so it is possible to reduce the high pressure transition temperature, while leaving the low pressure temperature high enough for good blocking.", "There are some important advantages to using the CPE resin for the CPF toner, rather than a small molecule crystalline material.", "Because CPE is a polymer, compared to the DST small molecule, there is an increased toughness and elasticity, which could be very important to produce a robust toner particle.", "Moreover, because CPE resins have been previously designed for emulsion aggregation (EA) toner control the acid number to get the required acid value is well known.", "Adjusting the acid value of a small molecule crystalline material is not as straightforward.", "Since the DST is a small molecule putting an acid group in every molecule would make the acid value much too high to make toner.", "So only a small number of the DST molecules for example could potentially have an acid group, to enable making a functional EA toner—acid number affects both toner making and toner performance in charging.", "Also, one of the easiest ways to add an acid group to the DST small molecule for example is to have only one stearate group and have the other functional group of the terephalate as a free acid group.", "However, this would change the melt and baroplastic behavior of those monostearyl terephalate acid molecules compared to those with DST.", "Another small molecule could be added with acid groups, but again this could impact baroplastic performance.", "These issues do not arise with the polymeric CPE.", "Example 3-Toner Production Latex Preparation: A latex of 190 nm size was prepared by co-emulsification of a 79/21 ratio of C10/C6 CPE (AV=10.2) and SYLVARES™TR A25 (AV=0).", "79 grams of C10/C6 CPE resin and 21 g of SYLVARES™TR A25 were measured into a 2 liter beaker containing about 1000 grams of ethyl acetate.", "The mixture was stirred at about 300 revolutions per minute at 65° C. to dissolve the resin and CCA in the ethyl acetate.", "6.38 grams of Dowfax (47 wt %) was measured into a 4 liter glass beaker containing about 1000 grams of deionized water.", "Homogenization of said water solution in said 4 liter glass beaker was commenced with an IKA Ultra Turrax T50 homogenizer at 4,000 revolutions per minute.", "The resin mixture solution was then slowly poured into the water solution as the mixture continues to be homogenized, the homogenizer speed is increased to 8,000 revolutions per minute and homogenization is carried out at these conditions for about 30 minutes.", "Upon completion of homogenization, the glass flask reactor and its contents are placed in a heating mantle and connected to a distillation device.", "The mixture is stirred at about 250 revolutions per minute and the temperature of said mixture is increased to 80° C. at about 1° C. per minute to distill off the ethyl acetate from the mixture.", "Stirring of the said mixture is continued at 80° C. for about 120 minutes followed by cooling at about 2° C. per minute to room temperature.", "The product is screened through a 25 micron sieve.", "The resulting resin emulsion is comprised of about 13.84 percent by weight solids in water, and has a volume average diameter of about 196.2 nanometers as measured with a HONEYWELL MICROTRAC® UPA150 particle size analyzer.", "Two further latexes were also prepared in a similar manner, except that 70 grams of C10/C6 CPE resin with 30 g of SYLVARES™TR A25 were used to prepare latex with 183.1 nm size at 17.52 wt % solid content, and 70 grams of C10/C6 CPE resin with 30 g of SYLVATAC□RE25 were used to prepare another latex of 139.6 nm size at 17.44 wt % solid content.", "Toner Preparation A: Into a 2 liter glass reactor equipped with an overhead stirrer was added 33.95 g PB15:3 dispersion (17.89 wt %), and 726.26 g above latex with 79 grams of C10/C6 CPE resin and 21 g of SYLVARES™TR A25.Above mixture had a pH of 3.71, then 20.17 grams of Al2(SO4)3 solution (1 wt %) was added as flocculent under homogenization.", "The temperature of mixture increased to 55° C. at 250 rpm.", "The particle size was monitored with a Coulter Counter until the core particles reached a volume average particle size of 7.42 μm.", "Thereafter, the pH of the reaction slurry was increased to 9.5 using 15.81 g EDTA (39 wt %) and NaOH (4 wt %) to freeze the toner growth.", "After freezing, the reaction mixture was heated to 70° C. The toner was quenched after coalescence, and it had a final particle size of 9.64 microns.", "The toner slurry was then cooled to room temperature, separated by sieving (25 μm), filtration, followed by washing and freeze dried.", "Toner preparation B: Into a 2 liter glass reactor equipped with an overhead stirrer was added 34.18 g PB15:3 dispersion (17.89 wt %), and 577.61 g (17.52 wt %) latex with C10/C6 CPE to SYLVARES™TR A25 at a ratio of 70 to 30.Above mixture had a pH of 3.70, then 56.15 grams of Al2(SO4)3 solution (1 wt %) was added as flocculent under homogenization.", "The temperature of mixture was increased to 60.5° C. at 250 rpm.", "The particle size was monitored with a Coulter Counter until the core particles reached a volume average particle size of 6.48 μm.", "Thereafter, the pH of the reaction slurry was increased to 9.5 using 13.08 g EDTA (39 wt %) and NaOH (4 wt %) to freeze the toner growth.", "After freezing, the reaction mixture was heated to 67.9° C. The toner was quenched after coalescence, and it had a final particle size of 8.24 microns.", "The toner slurry was then cooled to room temperature, separated by sieving (25 μm), filtration, followed by washing and freeze dried.", "Toner preparation C: Into a 2 liter glass reactor equipped with an overhead stirrer was added 38.70 g PB15:3 dispersion (16.00 wt %), and 571.97 g latex with C10/C6 CPE to SYLVATAC® RE25.Above mixture had a pH of 4.07, then 61.71 grams of Al2(SO4)3 solution (1 wt %) was added as flocculent under homogenization.", "The temperature of mixture was increased to 60.8° C. at 250 rpm.", "The particle size was monitored with a Coulter Counter until the core particles reached a volume average particle size of 6.75 μm.", "Thereafter, the pH of the reaction slurry was increased to 9.01 using NaOH (4 wt %) to freeze the toner growth.", "After freezing, the reaction mixture was heated to 68° C. The toner was quenched after coalescence, and it had a final particle size of 7.90 microns.", "The toner slurry was then cooled to room temperature, separated by sieving (25 μm), filtration, followed by washing and freeze dried.", "Table 7 shows the Shimadzu phase change transition temperature difference is not as large in the toner samples as it is in the simple mixtures of the CPE and small amorphous molecule in Table 6.For example in Table 6 the Sample 5 mixture with 79/21 ratio of CPE C10:C6/SYLVARES™ TR A25 had a shift with pressure of 17° C. to transition temperature of 53° C. at 100 kgf/cm2, compared to toner sample A with a shift with pressure of 3° C. to transition temperature of 68° C. at 100 kgf/cm2.Also in Table 6 the Sample 1 mixture with 70/30 ratio of CPE C10:C6/SYLVARES™ TR A25 had a shift with pressure of 25° C. to transition temperature of 45° C. at 100 kgf/cm2, compared to toner sample B with a shift with pressure of 4° C. to transition temperature of 68° C. at 100 Kgf/cm2, Also in Table 6 the Sample 10 mixture with 70/30 ratio of CPE C10:C6/SYLVATAC® RE40 had a shift with pressure of 17° C. to transition temperature of 45° C. at 100 kgf/cm2, compared to toner sample C with the same formulation with a shift with pressure of 7° C. to transition temperature of 62° C. at 100 kgf/cm2, As shown in Table 7 reduction in the phase transition temperature and the increase in the shift with pressure can be achieved with further increase in amorphous content.", "TABLE 7 Phase ChangeTransition CPE Properties Temperature ΔT Toner Mn Mw Mp (° C., 104 Pa-s) (° C.) Sample Material ID (k) (k) (° C.) 100 kgf/cm2 10 kgf/cm2 10 − 100 kgf/cm2 A 79/21 25.6 10.7 75.5 68 71 3 C12:C6/ SYLVARES ™ TR A25 B 70/30 25.6 10.7 75.5 65 69 4 C12:C6/ SYLVARES ™ TR A25 C 70/30 16.9 7.6 72.6 62 69 7 C12:C6/ SYLVATAC ® RE25" ] ]
Patent_15874292
[ [ "SYSTEM AND COMPUTER-BASED METHOD FOR SIMULATING A HUMAN-LIKE CONTROL BEHAVIOUR IN AN ENVIRONMENTAL CONTEXT", "A computer-based method for simulating a human-like decision in an environmental context, comprising: capturing environmental data with at least one sensor, realising a computer based method for realising a bi-directional compression of high dimensional data by compressing the data into a lower-dimensional map, if environmental data are captured during a learning phase of a computer-based model, evaluate the map of compressed data by determining the quality of the map by how well it separates data with different properties, the captured data corresponding to known pre-recorded data that have been pre-evaluated, if environmental data are captured after the learning phase, add new point to the compressed data and generate a signal indicating which human-like decision to use to correspond to the state of the operator." ], [ "1.A computer based method for realising a bi-directional compression of high dimensional data by compressing the data into a lower dimensional map, the method comprising a reception of data with a first dimension greater than one captured and transmitted by at least one sensor and a compression of the data or attributes derived from the data into compressed data with a second dimension lower than the first dimension, wherein, for two metric spaces X=(x,μx) and Y=(y,μy) with x a first space which dimension is greater or equal than the dimension of a second space y, μx a first metric on the first space x, μy a second metric on the second space y, the compression is realized by mapping pairs of points formed between a first set of n points P belonging to the first space x and a second set of n points Q belonging to the second space y, each point of the second set of n points Q being paired with a point of the first set of points P through the following equation: Q=argmintϵynd(A1(μx(P)),A2(μy(t))) (Equation 1) where μx(P) is a first symmetric distance matrix between points in P, μx(Q) is a second symmetric distance matrix between points in Q, and d(.,.)", "is a symmetric distance function on the space of square matrices, while A1 and A2 are any two functions holding the following properties: A:R+→[0, 1], A(0)=1, limx→∞A(z)=0, A(z1)>A(z2) if and only if z1<z2.2.The computer based method of claim 1, further comprising an extraction of attributes from at least one data before initiating the bi-directional compression.", "3.The computer based method according to claim 1, comprising a compression of a new point m belonging to the first space x on the second space y by solving the following equation: {tilde over (y)}=argmintϵynd(A1(μx(P,m)),A2(μy(Q,t))) (Equation 2) and a decompression of a new point t belonging to the second space y on the first space x by solving the following equation: {tilde over (x)}=argminmϵxnd(A1(μx(P,m)),A2(μy(Q,t))) (Equation 3) where μx(P,m) and μy(Q,t) are the distance vectors between the points of BiMap and the new points in the corresponding respective spaces, BiMap being a correspondence between points of the first space x and points of the second space y represented by equation 2 and equation 3, which Q points are calculated from points P by solving equation 1.4.A computer based method for simulating a human-like decision in an environmental context, comprising: capturing environmental data with at least one sensor, realising a computer based method for realising a bi-directional compression of high dimensional data by compressing the data into lower dimensional map according to claim 1 with the environmental data, if environmental data are captured during a learning phase of a computer-based model, evaluating the map of compressed data by determining the quality of the map by how well it separates data with different properties, the captured data corresponding to known pre-recorded data that have been pre-evaluated, if environmental data are captured after the learning phase, adding new points to the compressed data and generating a signal indicating which human-like decision to use to correspond to the state of the operator.", "5.The computer based method according to claim 4, comprising pre-processing the environmental data with at least one filter before realising the computer based method for realising a bi-directional compression of data, the computer based method for realising a bi-directional compression of data receiving as inputs filtered environmental data.", "6.The computer based method according to claim 4, wherein the environmental data comprise at least one sample of raw sound recorded inside a car's cockpit with at least one microphone, and the method further comprises inputting the environmental data into auditory models before pre-processing with at least one filter the data outputted by the auditory models deliver a plurality of different versions of the environmental data, the pre-processing being realized over every version of the environmental data.", "7.A system for simulating a human-like behaviour in an environmental context comprising at least one sensor to capture environmental data, and an architecture with a memory for interacting with dynamic behaviours of a tool and an operator, characterized in that architecture is configured to process the steps of the computer-based method for simulating a human-like decision in an environmental context according to claim 4.8.The system according to claim 7, wherein the memory of the architecture is an artificial memory, the architecture being a first neural network having structures and mechanisms for abstraction, generalisation and learning, the first neural network implementation defining the architecture comprising an artificial hierarchical memory system, comprising a receiving port configured to receive data generated by sensors (on the tool), one or more first nodes configured to learn and recognize frequently occurring input attributes and sequences received from the receiving port, the one or more first nodes forming a second neural network comprising neurons as components and edges connecting two or more of the neurons in a graph, and an output port configured to output data constructed by the architecture and associated with the behaviours, whereby each of the one or more or essentially all of the first nodes is adapted for time series analysis, and comprises components connected in a topological graph or temporal graph.", "9.The system according to claim 7, further comprising a pre-processing filter to apply a set of different filters to the environmental data captured by the at least one sensor.", "10.The system according to claim 7, wherein the environmental data comprise at least one sample of raw sound recorded inside a car's cockpit with a noise sensor, and the system further comprises auditory models configured to be applied to the recorded environmental data before the filtering pre-processing to output a plurality of different versions of the environmental data, the filtering pre-processing being realized over every version of the environmental data.", "11.A computer program product having software to realize the computer based method according to claim 4, which when executed on a processing engine, can contain code segments that provide a Perceptual/Cognitive architecture with artificial memory for interacting with dynamic behaviours of a tool and an operator, wherein the Perceptual/Cognitive architecture is based on a Memory Prediction Framework implementation having structures and mechanisms for abstraction and generalization and optionally learning, the memory Prediction Framework implementation comprising an enhanced artificial hierarchical memory system.", "12.An automotive vehicle comprising an electronic control unit including a system for simulating a human-like decision in an environmental context according to claim 7." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>The invention relates to a computer-based method for simulating a human-like control behaviour in an environmental context, and in particular such a system and method including a computer-based method for realising a bi-directional compression of data.", "Today, assisting systems are used for many applications in almost any kind of industry.", "Especially the automotive industry or the aviation industry as well as in computational industry assisting systems are commonly used to facilitate for a user the operating systems.", "In automotive industry, well known systems like ESC (Electronic Stability Control) for improving the safety of the vehicle's stability by detecting and minimizing of the skidding, or EBA (Emergency Brake Assist) to ensure maximum braking power in emergency situations by interpreting the speed and the force at which a brake pedal is pushed are widely-used.", "In aviation industry active autopilots or so called fly-by-wire systems are commonly used in modern civil as well as military aircrafts, where electronic interfaces replace the manual flight control by converting the movements of the flight controls into electronic signal and initiate flight control without human interference.", "Additionally, the number of sensors and actuators integrated in the systems, like vehicles or aircrafts, increases rapidly with the aim to watch over and/or control almost each and every component in these systems electronically.", "One problem arising from the increased number of sensors and actuators is the amount of data to be handled and/or analysed for recognising a specific situation or operational status of the systems.", "It is an intention of modern assisting systems to provide a robust, sensitive and real-time monitoring of human intention while operating a machine in a dynamically changing environment.", "Such modern assisting systems enable efficient and safe operation of a machine, optimized to actual human intended operation.", "Such machine may be any kind of system to be operated by a human, like e.g.", "a vehicle, an aircraft, a ship, a machine etc.", "as well as computational systems like, e.g.", "a computer game, or the like.", "In the following, the term “system” should be understood as any kind of these.", "Assisting systems generally use virtual development methods.", "Such methods are quickly gaining importance in the vehicle development process to cope with important business challenges; shortening time-to-market, optimising product quality, performance & value, reducing production & development costs, dealing with ever stricter emission & safety regulations.", "For example, a particular challenge in the Engine and Powertrain field is the upcoming European “Real Driving Emissions” (RDE) regulation.", "RDE compliance requires control of vehicle exhaust emissions over a wide area of operating conditions.", "This heavily impacts the engine calibration process which was traditionally based on a fixed driving cycle.", "Virtualising part of the calibration process allows evaluating the vehicle & engine behaviour under various real-life driving conditions by running a physical or grey-box vehicle model over a virtual driving environment, operated by a virtual Driver Model.", "Perceptual/cognitive architectures with an artificial (i.e.", "implemented on a machine, or in or as a computer or in or as a tool) memory system are used as such assisting systems.", "They are particularly suited for understanding and controlling the dynamic behaviours of a tool in response to the human operator, especially for actual and safe interactions of operator and tool in real-time in a dynamically variable environment.", "Document WO 2014 009031 relates to a method or system or architecture, in particular a perceptual/cognitive architecture with an artificial memory system, comprising: at least one first node being adapted to store and recall (e.g.", "long) input sequences, such (e.g.", "long) input sequences being modelled as an event; at least one second node being adapted to extract and save prototypes from raw data, each prototype being representative of data chunks, characterizing real world operation (of a tool within its environment) with features which are similar.", "In the architecture disclosed in this document, the second node provides the input for the first node.", "The raw data is typically data obtained from sensors, e.g.", "sensors that sense the activity of actuators or control elements of a machine or tool.", "An artificial memory system is generally composed of several nodes each of them solving a specific task like for example, one of the following ones: spatial pooling, signal quantization, temporal and forced temporal pooling, event and forced event pooling.", "The functionality of the whole system is achieved by connecting these nodes with different kind of oriented connections, like: Feed Forward (FF) input/output, Feed Back (FB) input/output, State Consistency Check, and so on.", "The Memory Prediction Framework (MPF) described in this document is in a particular embodiment an “artificial memory recalling system” inspired by the functioning of the mammalian neocortex, able to identify, store, recognize spatial/temporal patterns of sensed parameters, able of classifying the events being exposed to, and predicting over time.", "An MPF network is composed of a hierarchical set of nodes that can contain a neural gas-like adaptive memory system, able to analyse different spatial-temporal inputs in parallel and then communicate throughout the hierarchy in order to discover higher level behaviours and properties.", "The three main purposes of a node, which has an input and an output, are to learn and recognize peculiar input patterns, associate them to a number of external (possibly unknown) causes or events, and finally predict the next input pattern(s).", "To these aims two different phases are usually distinguished: the training phase, or learning phase, used to learn input patterns, which affects the internal “memory” of a node, and the inference phase which is the actual operational phase for a node during which input patterns are compared against memorized ones and FF and FB outputs are generated.", "Actually nothing prevents a node to operate in a “continuous learning” way in which training and inference are performed together.", "Another possibility is to have a very short initial training phase, used to overcome the “cold start” problem, followed by a continuous learning phase.", "In any case, the purpose for the inference phase is to evaluate the current input pattern in order to associate it to one or more, learned causes.", "This results in the generation of a FF output signal which represent the likelihood for the current input pattern to belong to one of the learned causes.", "This process is usually affected also by the FB input signal which represents a prediction for the current FF output signal provided by a parent node.", "This last feature is intended to permit a node to disambiguate among different causes which might share common input patterns: this is usually referred to as “focus of attention”, After the generation of the FF output a node should also generate a prediction for its next input pattern to be signalled to child nodes via its FB output: this might require to wait for all the network to finish the FF update in order to propagate prediction from top to bottom nodes.", "It is evident that the inter-nodes exchange of information by means of FF and FB connections is at the core of the memory prediction framework (MPF) such as disclosed in WO 2014009031 mentioned here above.", "Thus, the efficiency of communication between nodes impacts the whole system both in terms of the number of bits than can be exchanged, and the computational effort within the node.", "Indeed, the greater the efficiency is the more bits can be exchanged between two nodes and the less computational effort within a node is needed to process a same amount of data.", "Bi-directional mapping is a technique to perform dimensionality reduction avoiding the typical drawbacks of common techniques such as Principal Component Analysis (PCA) and manifold learning algorithms in general.", "In particular, avoid linearity, which is a constraint on the learned manifolds shape which results in maps with low accuracy, and avoid directionality, which contributes in the impossibility to recover original high dimensional points from their low dimensional representation.", "In the article entitled “Visualizing Data using t-SNE” by Laurens van der Maaten and Geoffrey Hinton and published in the Journal of Machine Learning Research, volume 1 (2008) pages 1-48, is disclosed a well-known computer based method named t-Distributed Stochastic Neighbour Embedding (t-SNE).", "The t-SNE method allows visualizing high-dimensional datasets exploiting a dimensionality reduction which preserves proximity without any possible inference on the visualisations." ], [ "<SOH> OBJECT AND SUMMARY OF THE INVENTION <EOH>The invention aims to improve a memory prediction framework global efficiency by performing an invertible dimensionality reduction on the inter-node communication which allows a data-dependent bi-directional mapping between high- and low-dimensional spaces.", "This goal is reached thanks to a computer based method for realising a bi-directional compression of data by compressing high dimensional data into a lower dimensional map, e.g.", "a two- or three-dimensional map, the method comprising a reception of data with a first dimension greater than one, for example data captured and transmitted by at least one sensor, and a compression of said data or attributes derived from said data, such as segments of GPS data or segments of data of the on-board electronic control unit of a vehicle, into compressed data with a second dimension lower than the first dimension.", "According to a general feature of this computer based method, for two metric spaces X=(x,μ x ) and Y=(y,μ y ) with x a first space which dimension is greater or equal than the dimension of a second space y, μ x a first metric on said first space x, μ y a metric on said second space y, and P being a first set of n points belonging to said first space x, a point being an element of a space, the compression is realized by finding a second set of n points Q belonging to said second space y such that: in-line-formulae description=\"In-line Formulae\" end=\"lead\"?", "Q =argmin tϵy n d ( A 1 (μ x ( P )), A 2 ( t )))  (Equation 1) in-line-formulae description=\"In-line Formulae\" end=\"tail\"?", "where d(.,.)", "is a symmetric distance function on the space of square matrices, while A 1 and A 2 are any two functions holding the following properties, A being any of A 1 or A 2 functions: A: R 4→ [0, 1], A(0)=1, lim x→∞ A(z)=0, A(z 1 )>A(z 2 ) if and only if z 1 <z 2 .", "A 1 and A 2 can be any function holding said properties, including: A  ( z ) = e - z s with s>0, or A  ( z ) = e - ( z s ) 2 , with s>0, or A  ( z ) = 1 1 + ( z s ) 2 with s>0, or A  ( z ) = 1 1 + ( z s ) with s>0.Once equation 1 is solved for each of the n points of the first set of n points P, correspondence between points, referenced as BiMap, of the two set of n points P and Q, ice, BiMap=(P,Q), can be used as a translation atlas to transform points of said first space x into points of said second space y and vice-versa by means of equations 2 and equation 3 which follow.", "First and second spaces x and y are general spaces where dimension of y is smaller than dimension of x.", "The computer-based method creates a correspondence between points in x and points in y.", "Thus the compression is achieved by having the points of y in a smaller dimension than the points of x.", "This compression method is defined so as to be bi-directional as it allows both compression and decompression of data, in contrast to the other manifold learning algorithms which allow only compression and not decompression of data.", "The two main difference between this computer based method and the t-SNE computer based method consists in the possibility given here to both add new point to a map without the need to re-compute the whole map, and create an inverse correspondence from matrix y to matrix x to recover a higher dimensional point from its lower dimensional representation.", "Indeed, t-SNE does not create any mapping and any addition of a new point constrains to re-compute all the data to visualize ft.", "The second difference with t-SNE is also the main difference with the standard manifold learning computer based methods as disclosed in the article entitled “Iterative non-linear dimensionality reduction with manifold sculpting” from Gashler et. al.", "and published in NIPS (2007), volume 8, pages 513-520, and in the article entitled “Diffusion maps” from Coffman et al and published in the magazine Applied and computational harmonic analysis, volume 21, issue 1, July 2006, pages 5-30.Moreover, depending on the choice of functions A 1 and A 2 the computer based method can accurately transport the proximity relation from P to Q, and/or can show self-clustering features, and/or help to highlight hidden patterns in data.", "For example if A1 and A2 are the same function then the proximity relation is accurately transported, while whenever A2 has a fatter tails than A1, then points which are not so close on x will be spread away on the projection over y, thus highlighting the neighborhood structure, i.e.", "the clustering, of the original points in x.", "In a first aspect of this computer based method, it further comprises an extraction of attributes from at least one data before initiating said bi-directional compression.", "The extraction of attributes from each data enables to already sort out the elements of each data considered as relevant for future operations and thus already realise a first compression of used data by only keeping the relevant parts, i.e.", "attributes, for the bi-directional compression into two- or three-dimensional maps.", "Moreover, the extraction of attributes such as spatiotemporal attributes helps simplifying the training of a computer-based model using the bi-directional mapping compression.", "In a second aspect of this computer based method, said compression method comprises a compression of a new point m belonging to matrix x on matrix y by solving the following equation: in-line-formulae description=\"In-line Formulae\" end=\"lead\"?", "{tilde over ( y )}=argmin tϵy n d ( A 1 (μ x ( P,m )), A 2 (μ y ( Q,t )))  (Equation 2) in-line-formulae description=\"In-line Formulae\" end=\"tail\"?", "and a decompression of a new point t belonging to matrix y on matrix x by solving the following equation: in-line-formulae description=\"In-line Formulae\" end=\"lead\"?", "{tilde over ( x )}=argmin mϵx n d ( A 1 (μ x ( P,m )), A 2 (μ y ( Q,t )))  (Equation 3) in-line-formulae description=\"In-line Formulae\" end=\"tail\"?", "where μ x (P,m) and μ y (Q,t) are the distance vectors between the points of BiMap and the new points in the corresponding respective spaces, BiMap is a correspondence between points of x and points of y given by Equation 2 (compressing) and equation (3) decompressing.", "Moreover A 1 (μ x (P,m)) or A 2 (μ y (Q,t)) can be used to assess an objective Map Distortion Index (MDI) when a new point m or t needs to be mapped in Y or X respectively.", "Indeed, the mapping accuracy obtained by this computer-based method depends on the closeness with respect to the points in the atlas BiMap=(P,Q).", "The dependence is expressed by searching the point which has minimum activation distortion from the learned ones, i.e.", "solving equation 2 or equation 3.The possibility to assess an MDI leads to both a point section scheme in the X space in order to have more accurate atlas and to an intrinsic anomaly detection mechanism to support or to implement the context check within the MPF.", "Another object of the invention is to provide a computer-based method for simulating a human-like decision in an environmental context.", "The method comprises the following steps: capturing environmental data with at least one sensor, realising a computer based method for realising a bi-directional compression of data by compressing high dimensional environmental data into a lower dimensional map as defined above, if environmental data are captured during a learning phase of a computer-based model, evaluating the map of compressed data by determining the quality of the map by how well it separates data with different properties, said captured data corresponding to known pre-recorded data that have been pre-evaluated, if environmental data are captured after said learning phase, add new points to said compressed data and generate a signal indicating which human-like decision to use to correspond to the state of the operator.", "Depending on the environmental context and the use of the method, the human-like decisions simulated can be human judgements about their environments taking into consideration some first type of environmental data like sounds for example, or human-like control behaviour control for example to predict what kind of action a human, a driver e.g., is going to take knowing some second type of environmental data like the position, the speed and the gear of the car, or other kinds of human-like decisions.", "Thus, in an architecture comprising a memory prediction framework, this computer-based method can act in three different ways: First as an input data pre-processing, second as an internode feedforward and feedback data compression, and third as a node output classifier.", "In the first configuration, i.e.", "the input data pre-processing, the role played by the bi-directional mapping computer-based compression method is to let the network process data from a domain with less dimensions, thus saving both memory and computational power.", "In the second configuration, i.e.", "the internode feedforward and feedback data compression, the bi-directional mapping computer-based compression method is used to compress feedforward outputting from the lowest level node and decompress the feedback outputting from the highest level one.", "In the third configuration, i.e.", "the node output classifier, the bi-directional mapping computer-based compression method helps to visualize the learning dynamics within a node, thus to help the human qualitative interpretation of the information stored in it.", "In this case the compression method acts as a clustering based classifier.", "In the second configuration, during inference tasks which happen after the end of the learning phase, according to WO 2014 009031 an MPF node computes the distance, with respect to a defined metric, between the current input and all its stored coincidences, hence it outputs the feedforward signal consisting in a distance related probability distribution of the input being a sample of the known stored coincidences.", "The space of coincidence, within a node, is coupled with a metric implying both that the coincidences have a naturally defined spatial notion within the node input space and that the feedforward signal is a codification of the input in terms of its position within the input space by using the coincidences as reference points.", "In other words, for any new input M the output of an MPF node N is the vector A N (μ N (C,m)), with A N (.)", "the activation function of the node N, μ N (.)", "its metric, and C the set of its coincidences.", "Thus the output of any node is the first half of equation 2 and symmetrically a feedback output is the second part of equation 3.In particular, the dimensionality of the output of each node increases with the memory size of the node itself.", "During real-world usage of the MPF, i.e.", "during inference phase, it is possible to have nodes with output dimensionality of hundreds or thousands of probabilities.", "The need for dimensionality reduction is important when stacking nodes in a hierarchy, like the MPF, since the nodes in the above levels must learn from the output of the nodes in the lower ones.", "In particular a smaller dimension input means reduced computational power needed to perform all the MPF capabilities.", "This problem is even more relevant when a higher level node receives as input the output of several lower level ones, then the dimension of its input space grows accordingly to the sum of the number of coincidences of its input nodes.", "The need of back projection in feedback connections clearly follows, since it is mandatory for many MPF features.", "Moreover, whenever the order of C exceeds by at least one the number of dimension of the input space N, there is a one to one correspondence between the position of the input m within the node input space and the space of the feedforward signals in output, meaning that any further correspondence add redundancy to A N (μ N (C,m)) which can be cleared out by said compression method.", "Nowadays, the sound quality of a car is a very important aspect considered by a consumer, for example when buying a new car.", "Since the sound quality is mostly a subjective aspect, there are no reliable ways to objectively evaluate the quality.", "Therefore the evaluation step during the car development usually relies on judgments given by experts, often on a relative scale between different cars.", "Thus, this aspect of this computer-based method enables to objectify the subjective judgments of car sounds, in other words it enables to objectify the process of evaluating car sounds.", "In a first aspect of the computer-based method for simulating a human-like decision in an environmental context, said computer-based method comprises pre-processing said environmental data with at least one filter before realising the computer based method for realising a bi-directional compression of data, said computer based method for realising a bi-directional compression of data receiving as input filtered environmental data.", "This additional step enables, especially in an application to car audio sound treatment, the environmental data to go through a series of filters, such as band-pass filters, and pre-processing steps which helps increasing and diversifying the amount of information treated.", "For instance, in an application to car audio sound treatment, pre-processing steps can include denoising, convolution or any possible audio processing.", "In general it can be any kind of data operation or feature extraction.", "An MPF architecture is mostly un-supervised and data-driven.", "Therefore, filtering out data may help in excluding useless or misleading information, helping MPF to focus on more important features.", "In a second aspect of the computer-based method for simulating a human-like decision in an environmental context, the environmental data comprise at least one sample of raw sound recorded inside a car's cockpit with a noise sensor, and said method further comprises inputting said environmental data into auditory models before pre-processing with at least one filter the data outputted by said auditory models to deliver a plurality of different versions of the environmental data, said pre-processing being realized over every version of the environmental data.", "Thus, this aspect of this computer-based method enables to objectify the subjective judgments of car sounds, in other words it enables to objectify the process of evaluating car sounds.", "The raw sound can be recorded by using high fidelity microphones synchronized with the CAN bus data, i.e.", "the controller area network.", "Auditory models are bio-inspired techniques to transform acoustic data into psycho-acoustic data.", "The correspondences between physical sound properties and human perception are complicated and far from being linear.", "Several operations are performed such as integration, temporal and frequency masking.", "From a computational point of view, an auditory model can be seen as a bank of filters whose task is to reproduce the operations performed by the human ear.", "This approach is widely used in speech recognition, but rarely considered in the automotive field.", "The raw recorded sound is processed using the auditory models presented in scientific literature.", "The output of this step is the amount of energy in a set of determined frequency bands, considering the effects of the different auditory models, such as frequency selection, frequency and temporal masking.", "A set of different Auditory Models are used to generate a plurality of “psychoacoustic versions” of the same raw sound to be processed in the following steps.", "Another object of the invention is to propose a system for simulating a human-like behaviour in an environmental context comprising at least one sensor to capture environmental data, and an architecture with a memory for interacting with dynamic behaviours of a tool and an operator.", "According to a general feature of the system for simulating a human-like behaviour in an environmental context, the architecture are configured to process the steps of said computer-based method for simulating a human-like decision in an environmental context defined here above.", "Moreover, all the features in application WO 2014 009031 are integrated in the present specification.", "In a first aspect of the system for simulating a human-like behaviour in an environmental context, the memory of the architecture is an artificial memory, the architecture being a first neural network having structures and mechanisms for abstraction, generalisation and learning, the first neural network implementation comprising an artificial hierarchical memory system, comprising a receiving port configured to receive data generated by sensors (on the tool), one or more first nodes configured to learn and recognize frequently occurring input attributes and sequences received from the receiving port, said one or more first nodes forming a second neural network comprising neurons as components and edges connecting two or more of said neurons in a graph, and an output port configured to output data constructed by the architecture and associated with the behaviours, whereby each of the one or more or essentially all of said first nodes is adapted for time series analysis, and comprises components connected in a topological graph or temporal graph.", "In a second aspect of the system for simulating a human-like behaviour in an environmental context, it comprises a pre-processing filter to apply a set of different filters to the environmental data captured by the at least one sensor.", "In a third aspect of the system for simulating a human-like behaviour in an environmental context, the environmental data comprise at least one sample of raw sound recorded inside a cares cockpit with a noise sensor, and said system further comprises auditory models configured to be applied to said recorded environmental data before the filtering pre-processing to output a plurality of different versions of the environmental data, said filtering pre-processing being realized over every version of the environmental data.", "Another object of the invention is to propose an automotive vehicle comprising an electronic control unit including a system for simulating a humanlike behaviour in an environmental context." ], [ "BACKGROUND OF THE INVENTION The invention relates to a computer-based method for simulating a human-like control behaviour in an environmental context, and in particular such a system and method including a computer-based method for realising a bi-directional compression of data.", "Today, assisting systems are used for many applications in almost any kind of industry.", "Especially the automotive industry or the aviation industry as well as in computational industry assisting systems are commonly used to facilitate for a user the operating systems.", "In automotive industry, well known systems like ESC (Electronic Stability Control) for improving the safety of the vehicle's stability by detecting and minimizing of the skidding, or EBA (Emergency Brake Assist) to ensure maximum braking power in emergency situations by interpreting the speed and the force at which a brake pedal is pushed are widely-used.", "In aviation industry active autopilots or so called fly-by-wire systems are commonly used in modern civil as well as military aircrafts, where electronic interfaces replace the manual flight control by converting the movements of the flight controls into electronic signal and initiate flight control without human interference.", "Additionally, the number of sensors and actuators integrated in the systems, like vehicles or aircrafts, increases rapidly with the aim to watch over and/or control almost each and every component in these systems electronically.", "One problem arising from the increased number of sensors and actuators is the amount of data to be handled and/or analysed for recognising a specific situation or operational status of the systems.", "It is an intention of modern assisting systems to provide a robust, sensitive and real-time monitoring of human intention while operating a machine in a dynamically changing environment.", "Such modern assisting systems enable efficient and safe operation of a machine, optimized to actual human intended operation.", "Such machine may be any kind of system to be operated by a human, like e.g.", "a vehicle, an aircraft, a ship, a machine etc.", "as well as computational systems like, e.g.", "a computer game, or the like.", "In the following, the term “system” should be understood as any kind of these.", "Assisting systems generally use virtual development methods.", "Such methods are quickly gaining importance in the vehicle development process to cope with important business challenges; shortening time-to-market, optimising product quality, performance & value, reducing production & development costs, dealing with ever stricter emission & safety regulations.", "For example, a particular challenge in the Engine and Powertrain field is the upcoming European “Real Driving Emissions” (RDE) regulation.", "RDE compliance requires control of vehicle exhaust emissions over a wide area of operating conditions.", "This heavily impacts the engine calibration process which was traditionally based on a fixed driving cycle.", "Virtualising part of the calibration process allows evaluating the vehicle & engine behaviour under various real-life driving conditions by running a physical or grey-box vehicle model over a virtual driving environment, operated by a virtual Driver Model.", "Perceptual/cognitive architectures with an artificial (i.e.", "implemented on a machine, or in or as a computer or in or as a tool) memory system are used as such assisting systems.", "They are particularly suited for understanding and controlling the dynamic behaviours of a tool in response to the human operator, especially for actual and safe interactions of operator and tool in real-time in a dynamically variable environment.", "Document WO 2014 009031 relates to a method or system or architecture, in particular a perceptual/cognitive architecture with an artificial memory system, comprising: at least one first node being adapted to store and recall (e.g.", "long) input sequences, such (e.g.", "long) input sequences being modelled as an event; at least one second node being adapted to extract and save prototypes from raw data, each prototype being representative of data chunks, characterizing real world operation (of a tool within its environment) with features which are similar.", "In the architecture disclosed in this document, the second node provides the input for the first node.", "The raw data is typically data obtained from sensors, e.g.", "sensors that sense the activity of actuators or control elements of a machine or tool.", "An artificial memory system is generally composed of several nodes each of them solving a specific task like for example, one of the following ones: spatial pooling, signal quantization, temporal and forced temporal pooling, event and forced event pooling.", "The functionality of the whole system is achieved by connecting these nodes with different kind of oriented connections, like: Feed Forward (FF) input/output, Feed Back (FB) input/output, State Consistency Check, and so on.", "The Memory Prediction Framework (MPF) described in this document is in a particular embodiment an “artificial memory recalling system” inspired by the functioning of the mammalian neocortex, able to identify, store, recognize spatial/temporal patterns of sensed parameters, able of classifying the events being exposed to, and predicting over time.", "An MPF network is composed of a hierarchical set of nodes that can contain a neural gas-like adaptive memory system, able to analyse different spatial-temporal inputs in parallel and then communicate throughout the hierarchy in order to discover higher level behaviours and properties.", "The three main purposes of a node, which has an input and an output, are to learn and recognize peculiar input patterns, associate them to a number of external (possibly unknown) causes or events, and finally predict the next input pattern(s).", "To these aims two different phases are usually distinguished: the training phase, or learning phase, used to learn input patterns, which affects the internal “memory” of a node, and the inference phase which is the actual operational phase for a node during which input patterns are compared against memorized ones and FF and FB outputs are generated.", "Actually nothing prevents a node to operate in a “continuous learning” way in which training and inference are performed together.", "Another possibility is to have a very short initial training phase, used to overcome the “cold start” problem, followed by a continuous learning phase.", "In any case, the purpose for the inference phase is to evaluate the current input pattern in order to associate it to one or more, learned causes.", "This results in the generation of a FF output signal which represent the likelihood for the current input pattern to belong to one of the learned causes.", "This process is usually affected also by the FB input signal which represents a prediction for the current FF output signal provided by a parent node.", "This last feature is intended to permit a node to disambiguate among different causes which might share common input patterns: this is usually referred to as “focus of attention”, After the generation of the FF output a node should also generate a prediction for its next input pattern to be signalled to child nodes via its FB output: this might require to wait for all the network to finish the FF update in order to propagate prediction from top to bottom nodes.", "It is evident that the inter-nodes exchange of information by means of FF and FB connections is at the core of the memory prediction framework (MPF) such as disclosed in WO 2014009031 mentioned here above.", "Thus, the efficiency of communication between nodes impacts the whole system both in terms of the number of bits than can be exchanged, and the computational effort within the node.", "Indeed, the greater the efficiency is the more bits can be exchanged between two nodes and the less computational effort within a node is needed to process a same amount of data.", "Bi-directional mapping is a technique to perform dimensionality reduction avoiding the typical drawbacks of common techniques such as Principal Component Analysis (PCA) and manifold learning algorithms in general.", "In particular, avoid linearity, which is a constraint on the learned manifolds shape which results in maps with low accuracy, and avoid directionality, which contributes in the impossibility to recover original high dimensional points from their low dimensional representation.", "In the article entitled “Visualizing Data using t-SNE” by Laurens van der Maaten and Geoffrey Hinton and published in the Journal of Machine Learning Research, volume 1 (2008) pages 1-48, is disclosed a well-known computer based method named t-Distributed Stochastic Neighbour Embedding (t-SNE).", "The t-SNE method allows visualizing high-dimensional datasets exploiting a dimensionality reduction which preserves proximity without any possible inference on the visualisations.", "OBJECT AND SUMMARY OF THE INVENTION The invention aims to improve a memory prediction framework global efficiency by performing an invertible dimensionality reduction on the inter-node communication which allows a data-dependent bi-directional mapping between high- and low-dimensional spaces.", "This goal is reached thanks to a computer based method for realising a bi-directional compression of data by compressing high dimensional data into a lower dimensional map, e.g.", "a two- or three-dimensional map, the method comprising a reception of data with a first dimension greater than one, for example data captured and transmitted by at least one sensor, and a compression of said data or attributes derived from said data, such as segments of GPS data or segments of data of the on-board electronic control unit of a vehicle, into compressed data with a second dimension lower than the first dimension.", "According to a general feature of this computer based method, for two metric spaces X=(x,μx) and Y=(y,μy) with x a first space which dimension is greater or equal than the dimension of a second space y, μx a first metric on said first space x, μy a metric on said second space y, and P being a first set of n points belonging to said first space x, a point being an element of a space, the compression is realized by finding a second set of n points Q belonging to said second space y such that: Q=argmintϵynd(A1(μx(P)),A2(t))) (Equation 1) where d(.,.)", "is a symmetric distance function on the space of square matrices, while A1 and A2 are any two functions holding the following properties, A being any of A1 or A2 functions: A: R4→[0, 1], A(0)=1, limx→∞A(z)=0, A(z1)>A(z2) if and only if z1<z2.A1 and A2 can be any function holding said properties, including: A  ( z ) = e - z s with s>0, or A  ( z ) = e - ( z s ) 2 , with s>0, or A  ( z ) = 1 1 + ( z s ) 2 with s>0, or A  ( z ) = 1 1 + ( z s ) with s>0.Once equation 1 is solved for each of the n points of the first set of n points P, correspondence between points, referenced as BiMap, of the two set of n points P and Q, ice, BiMap=(P,Q), can be used as a translation atlas to transform points of said first space x into points of said second space y and vice-versa by means of equations 2 and equation 3 which follow.", "First and second spaces x and y are general spaces where dimension of y is smaller than dimension of x.", "The computer-based method creates a correspondence between points in x and points in y.", "Thus the compression is achieved by having the points of y in a smaller dimension than the points of x.", "This compression method is defined so as to be bi-directional as it allows both compression and decompression of data, in contrast to the other manifold learning algorithms which allow only compression and not decompression of data.", "The two main difference between this computer based method and the t-SNE computer based method consists in the possibility given here to both add new point to a map without the need to re-compute the whole map, and create an inverse correspondence from matrix y to matrix x to recover a higher dimensional point from its lower dimensional representation.", "Indeed, t-SNE does not create any mapping and any addition of a new point constrains to re-compute all the data to visualize ft.", "The second difference with t-SNE is also the main difference with the standard manifold learning computer based methods as disclosed in the article entitled “Iterative non-linear dimensionality reduction with manifold sculpting” from Gashler et. al.", "and published in NIPS (2007), volume 8, pages 513-520, and in the article entitled “Diffusion maps” from Coffman et al and published in the magazine Applied and computational harmonic analysis, volume 21, issue 1, July 2006, pages 5-30.Moreover, depending on the choice of functions A1 and A2 the computer based method can accurately transport the proximity relation from P to Q, and/or can show self-clustering features, and/or help to highlight hidden patterns in data.", "For example if A1 and A2 are the same function then the proximity relation is accurately transported, while whenever A2 has a fatter tails than A1, then points which are not so close on x will be spread away on the projection over y, thus highlighting the neighborhood structure, i.e.", "the clustering, of the original points in x.", "In a first aspect of this computer based method, it further comprises an extraction of attributes from at least one data before initiating said bi-directional compression.", "The extraction of attributes from each data enables to already sort out the elements of each data considered as relevant for future operations and thus already realise a first compression of used data by only keeping the relevant parts, i.e.", "attributes, for the bi-directional compression into two- or three-dimensional maps.", "Moreover, the extraction of attributes such as spatiotemporal attributes helps simplifying the training of a computer-based model using the bi-directional mapping compression.", "In a second aspect of this computer based method, said compression method comprises a compression of a new point m belonging to matrix x on matrix y by solving the following equation: {tilde over (y)}=argmintϵynd(A1(μx(P,m)),A2(μy(Q,t))) (Equation 2) and a decompression of a new point t belonging to matrix y on matrix x by solving the following equation: {tilde over (x)}=argminmϵxnd(A1(μx(P,m)),A2(μy(Q,t))) (Equation 3) where μx(P,m) and μy(Q,t) are the distance vectors between the points of BiMap and the new points in the corresponding respective spaces, BiMap is a correspondence between points of x and points of y given by Equation 2 (compressing) and equation (3) decompressing.", "Moreover A1(μx(P,m)) or A2(μy(Q,t)) can be used to assess an objective Map Distortion Index (MDI) when a new point m or t needs to be mapped in Y or X respectively.", "Indeed, the mapping accuracy obtained by this computer-based method depends on the closeness with respect to the points in the atlas BiMap=(P,Q).", "The dependence is expressed by searching the point which has minimum activation distortion from the learned ones, i.e.", "solving equation 2 or equation 3.The possibility to assess an MDI leads to both a point section scheme in the X space in order to have more accurate atlas and to an intrinsic anomaly detection mechanism to support or to implement the context check within the MPF.", "Another object of the invention is to provide a computer-based method for simulating a human-like decision in an environmental context.", "The method comprises the following steps: capturing environmental data with at least one sensor, realising a computer based method for realising a bi-directional compression of data by compressing high dimensional environmental data into a lower dimensional map as defined above, if environmental data are captured during a learning phase of a computer-based model, evaluating the map of compressed data by determining the quality of the map by how well it separates data with different properties, said captured data corresponding to known pre-recorded data that have been pre-evaluated, if environmental data are captured after said learning phase, add new points to said compressed data and generate a signal indicating which human-like decision to use to correspond to the state of the operator.", "Depending on the environmental context and the use of the method, the human-like decisions simulated can be human judgements about their environments taking into consideration some first type of environmental data like sounds for example, or human-like control behaviour control for example to predict what kind of action a human, a driver e.g., is going to take knowing some second type of environmental data like the position, the speed and the gear of the car, or other kinds of human-like decisions.", "Thus, in an architecture comprising a memory prediction framework, this computer-based method can act in three different ways: First as an input data pre-processing, second as an internode feedforward and feedback data compression, and third as a node output classifier.", "In the first configuration, i.e.", "the input data pre-processing, the role played by the bi-directional mapping computer-based compression method is to let the network process data from a domain with less dimensions, thus saving both memory and computational power.", "In the second configuration, i.e.", "the internode feedforward and feedback data compression, the bi-directional mapping computer-based compression method is used to compress feedforward outputting from the lowest level node and decompress the feedback outputting from the highest level one.", "In the third configuration, i.e.", "the node output classifier, the bi-directional mapping computer-based compression method helps to visualize the learning dynamics within a node, thus to help the human qualitative interpretation of the information stored in it.", "In this case the compression method acts as a clustering based classifier.", "In the second configuration, during inference tasks which happen after the end of the learning phase, according to WO 2014 009031 an MPF node computes the distance, with respect to a defined metric, between the current input and all its stored coincidences, hence it outputs the feedforward signal consisting in a distance related probability distribution of the input being a sample of the known stored coincidences.", "The space of coincidence, within a node, is coupled with a metric implying both that the coincidences have a naturally defined spatial notion within the node input space and that the feedforward signal is a codification of the input in terms of its position within the input space by using the coincidences as reference points.", "In other words, for any new input M the output of an MPF node N is the vector AN(μN(C,m)), with AN(.)", "the activation function of the node N, μN(.)", "its metric, and C the set of its coincidences.", "Thus the output of any node is the first half of equation 2 and symmetrically a feedback output is the second part of equation 3.In particular, the dimensionality of the output of each node increases with the memory size of the node itself.", "During real-world usage of the MPF, i.e.", "during inference phase, it is possible to have nodes with output dimensionality of hundreds or thousands of probabilities.", "The need for dimensionality reduction is important when stacking nodes in a hierarchy, like the MPF, since the nodes in the above levels must learn from the output of the nodes in the lower ones.", "In particular a smaller dimension input means reduced computational power needed to perform all the MPF capabilities.", "This problem is even more relevant when a higher level node receives as input the output of several lower level ones, then the dimension of its input space grows accordingly to the sum of the number of coincidences of its input nodes.", "The need of back projection in feedback connections clearly follows, since it is mandatory for many MPF features.", "Moreover, whenever the order of C exceeds by at least one the number of dimension of the input space N, there is a one to one correspondence between the position of the input m within the node input space and the space of the feedforward signals in output, meaning that any further correspondence add redundancy to AN(μN(C,m)) which can be cleared out by said compression method.", "Nowadays, the sound quality of a car is a very important aspect considered by a consumer, for example when buying a new car.", "Since the sound quality is mostly a subjective aspect, there are no reliable ways to objectively evaluate the quality.", "Therefore the evaluation step during the car development usually relies on judgments given by experts, often on a relative scale between different cars.", "Thus, this aspect of this computer-based method enables to objectify the subjective judgments of car sounds, in other words it enables to objectify the process of evaluating car sounds.", "In a first aspect of the computer-based method for simulating a human-like decision in an environmental context, said computer-based method comprises pre-processing said environmental data with at least one filter before realising the computer based method for realising a bi-directional compression of data, said computer based method for realising a bi-directional compression of data receiving as input filtered environmental data.", "This additional step enables, especially in an application to car audio sound treatment, the environmental data to go through a series of filters, such as band-pass filters, and pre-processing steps which helps increasing and diversifying the amount of information treated.", "For instance, in an application to car audio sound treatment, pre-processing steps can include denoising, convolution or any possible audio processing.", "In general it can be any kind of data operation or feature extraction.", "An MPF architecture is mostly un-supervised and data-driven.", "Therefore, filtering out data may help in excluding useless or misleading information, helping MPF to focus on more important features.", "In a second aspect of the computer-based method for simulating a human-like decision in an environmental context, the environmental data comprise at least one sample of raw sound recorded inside a car's cockpit with a noise sensor, and said method further comprises inputting said environmental data into auditory models before pre-processing with at least one filter the data outputted by said auditory models to deliver a plurality of different versions of the environmental data, said pre-processing being realized over every version of the environmental data.", "Thus, this aspect of this computer-based method enables to objectify the subjective judgments of car sounds, in other words it enables to objectify the process of evaluating car sounds.", "The raw sound can be recorded by using high fidelity microphones synchronized with the CAN bus data, i.e.", "the controller area network.", "Auditory models are bio-inspired techniques to transform acoustic data into psycho-acoustic data.", "The correspondences between physical sound properties and human perception are complicated and far from being linear.", "Several operations are performed such as integration, temporal and frequency masking.", "From a computational point of view, an auditory model can be seen as a bank of filters whose task is to reproduce the operations performed by the human ear.", "This approach is widely used in speech recognition, but rarely considered in the automotive field.", "The raw recorded sound is processed using the auditory models presented in scientific literature.", "The output of this step is the amount of energy in a set of determined frequency bands, considering the effects of the different auditory models, such as frequency selection, frequency and temporal masking.", "A set of different Auditory Models are used to generate a plurality of “psychoacoustic versions” of the same raw sound to be processed in the following steps.", "Another object of the invention is to propose a system for simulating a human-like behaviour in an environmental context comprising at least one sensor to capture environmental data, and an architecture with a memory for interacting with dynamic behaviours of a tool and an operator.", "According to a general feature of the system for simulating a human-like behaviour in an environmental context, the architecture are configured to process the steps of said computer-based method for simulating a human-like decision in an environmental context defined here above.", "Moreover, all the features in application WO 2014 009031 are integrated in the present specification.", "In a first aspect of the system for simulating a human-like behaviour in an environmental context, the memory of the architecture is an artificial memory, the architecture being a first neural network having structures and mechanisms for abstraction, generalisation and learning, the first neural network implementation comprising an artificial hierarchical memory system, comprising a receiving port configured to receive data generated by sensors (on the tool), one or more first nodes configured to learn and recognize frequently occurring input attributes and sequences received from the receiving port, said one or more first nodes forming a second neural network comprising neurons as components and edges connecting two or more of said neurons in a graph, and an output port configured to output data constructed by the architecture and associated with the behaviours, whereby each of the one or more or essentially all of said first nodes is adapted for time series analysis, and comprises components connected in a topological graph or temporal graph.", "In a second aspect of the system for simulating a human-like behaviour in an environmental context, it comprises a pre-processing filter to apply a set of different filters to the environmental data captured by the at least one sensor.", "In a third aspect of the system for simulating a human-like behaviour in an environmental context, the environmental data comprise at least one sample of raw sound recorded inside a cares cockpit with a noise sensor, and said system further comprises auditory models configured to be applied to said recorded environmental data before the filtering pre-processing to output a plurality of different versions of the environmental data, said filtering pre-processing being realized over every version of the environmental data.", "Another object of the invention is to propose an automotive vehicle comprising an electronic control unit including a system for simulating a humanlike behaviour in an environmental context.", "BRIEF DESCRIPTION OF THE DRAWINGS The invention will be better understood by reading here after, as examples and in a non-limitative way, in reference to the enclosed drawings on which: FIG.", "1 shows schematically an artificial memory system according to an embodiment of the present invention; FIG.", "2 shows a diagram of a computer-based method for simulating a human-like behaviour in an environmental context.", "DETAILED DESCRIPTION OF THE, EMBODIMENTS The present invention will be described with respect to particular embodiments and with reference to certain drawings but the invention is not limited thereto but only by the claims.", "The drawings described are only schematic and are non-limiting.", "In the drawings, the size of some of the elements may be exaggerated and not drawn on scale for illustrative purposes.", "Where the term “comprising” is used in the present description and claims, it does not exclude other elements or steps.", "Where an indefinite or definite article is used when referring to a singular noun e.g.", "“a” or “an”, “the”, this includes a plural of that noun unless something else is specifically stated.", "The term “comprising”, used in the claims, should not be interpreted as being restricted to the means listed thereafter; it does not exclude other elements or steps.", "Thus, the scope of the expression “a device comprising means A and B” should not be limited to devices consisting only of components A and B.", "It means that with respect to the present invention, the only relevant components of the device are A and B.", "Furthermore, the terms first, second, third and the like in the description and in the claims, are used for distinguishing between similar elements and not necessarily for describing a sequential or chronological order.", "It is to be understood that the terms so used are interchangeable under appropriate circumstances and that the embodiments of the invention described herein are capable of operation in other sequences than described or illustrated herein.", "In FIG.", "1 is schematically presented a system 100 for simulating a human-like behaviour in an environmental context according to an embodiment of the invention.", "The simulation system 100 comprises two sensors 110 configured to capture environmental data.", "In this embodiment, the sensors 110 are two high fidelity microphones placed in two different locations inside a cockpit of a car.", "The simulation system further comprises an architecture with an artificial memory system 120 configured to interact with dynamic behaviours of a tool and an operator.", "The architecture with an artificial memory system 120 is made of a first neural network having structures and mechanisms for abstraction, generalisation and learning.", "The first neural network implementation comprises an artificial hierarchical memory system 130 comprising a receiving port configured to receive data generated by the microphones 110, one or more first nodes 140 configured to learn and recognize frequently occurring input attributes and sequences received from the receiving port, and one or more second nodes 150.The one or more first nodes 140 form a second neural network comprising neurons as components and edges connecting two or more of said neurons in a graph, and an output port configured to output data constructed by the architecture and associated with the behaviours, whereby each of the one or more or essentially all of said first nodes is adapted for time series analysis, and comprises components connected in a topological graph or temporal graph.", "In embodiments of the present invention a human operator is mentioned such as a driver, captain, pilot, gamer.", "Such a person can be “autonomous”.", "For example the operator commands can be given a priori, in the form of commands stored on a suitable storage medium that can be read by the system.", "For example if the operator is a driver and the tool is a vehicle such as an automobile, the commands might be destinations, expected times of arrival, expected fuel consumption, whether to drive aggressively, sportily, calmly etc.", "The actual human driver can also intentionally switch on the system and a command can be provided to drive the driver to the destination in such a way that accelerations, braking force, speed, fuel consumption etc.", "are according to the driver's normal behaviour or other behaviour.", "Also the system can take over in case of lack of commands.", "For example if it is detected that the driver is asleep the system brings the vehicle safely to a stand-still.", "Whether the driver has fallen asleep can be detected by an Awareness Check.", "Embodiments of the present invention are based on the Memory Prediction Framework (MPF) and include an artificial hierarchical memory system.", "The artificial hierarchical memory system can be enhanced Hierarchical Temporal Memory (HIM) with improved capabilities for scene recognition/“classification” and/or a pre-processing stage.", "The system and method have been adapted to be able among others, to provide a number such as 10-15 samples or any suitable number of samples required, for e.g.", "more or less than half a second depending on the sampling frequency, a prediction about input operator commands due to the introduction of temporal events management as well as the above-mentioned pre-processing stage.", "The architecture of the embodiment of FIG.", "1 corresponds to the architecture described in document WO 2014 009031 comprising an enhanced hierarchical memory.", "The Memory Prediction Framework is appropriate as a fundamental model, as it foresees nearly all the structures and mechanisms necessary for good learning, abstraction and generalization, e.g.", "feed-forward and feed-back signal flows within the network, their correspondence as measure of the degree of understanding of the situation, which is a prerequisite for assessing the generalization capabilities of the network.", "The MPF computational approach and its learning algorithms have been proven to deal well with diverse sensory channels, although sensory-specific pre-processing or tuning is still required.", "Once setup, i.e.", "adapted to a particular sensor modality no pre-processing is in principle required.", "However, it may from time to time be applied with advantage, for example as previously mentioned so-called primitives.", "Embodiments of the present invention may be seen as instantiations of suitable parts of the MPF.", "FIG.", "2 schematically presents a computer-based method for simulating a human-like decision in an environmental context.", "This simulation method is realised by the nodes 140 and 150 inside the artificial hierarchical memory 130 of the simulation system 100.In this example, the human-like decision is a behaviour of a driver of a car and the environmental context taken into account corresponds to the sounds surrounding him.", "In a first step 10 of the simulation method, several high fidelity microphones synchronized with the CAN bus data record raw sounds inside the cockpit of the car.", "The raw sounds recorded are in a high dimensional configuration, for example a three dimension configuration.", "In a second step 12 of the simulation method, the electronic signals corresponding to the recorded raw sounds are sent to the architecture with said artificial memory system 120 and are pre-processed through a set of auditory models to generate a plurality of “psychoacoustic versions” of each recorded raw sound which will be inputted into the artificial memory system 120 after a filtering step.", "In a third step 14 of the simulation method, the electronic signals corresponding to the multiple psychoacoustic versions of each recorded raw sound are pre-processed through a set of band-pass filters.", "In a following step 16 of the simulation method, the filtered sounds are sent to nodes to be processed by using a computer-based method for realising a bi-directional compression of data by compressing said filtered data into a two-dimensional map.", "In step 18, a following step of the simulation method and first step of the compression method, the filtered sounds are received by other nodes or the same nodes.", "In a second step 20 of the compression method, the nodes operate an extraction of attributes from each filtered raw sound in order to sort out the elements of each data considered as relevant for the method for simulating a human-like control behaviour.", "The attributes extracted are e.g.", "spatiotemporal attributes in order to simplify the training of the computer-based method for simulating a human-like control behaviour.", "In a third step 22 of the compression method, the nodes operate a compression of the attributes extracted from the filtered raw sounds.", "The compression is realized by finding a set of n points Q belonging to a matrix y such that: Q=arginintϵynd(A1(μx(P)),A2(μy(t))) (Equation 1) X=(x,μx) and Y=(y,μy) being a two metric spaces with x a first space which dimension is greater or equal than the dimension of a second space y, μx a first metric on space x, μy a second metric on space y, and P being a first set of n points belonging to said first space x, and d(.,.)", "being a symmetric distance function on the space of square matrices, while A1 and A2 are any two functions holding the following properties: A:R30 →[0, 1], i.e.", "A being a function defined for all positive real numbers and generating a value between 0 and 1, 0 and 1 being included; A(0)=1, i.e.", "A being a function for which argument 0 will generate the value 1, limx→∞A(z)=0, i.e.", "A being a function which has 0 for a limit as the argument approaches grows, A(z1)>A(z2) if and only if z1<z2, i.e.", "A being a strictly decreasing function.", "Once equation 1 is solved for each of the n points of the first set of n points P, the correspondence between points, referenced as BiMap, of the two set of n points P and Q, i.e.", "BiMap=(P,Q), can be used as a translation atlas to transform points of said first space x into points of said second space y and vice-versa by means of equations 2 and equation 3, which follow.", "With such a step, new points can thus be added to a map without the need to re-compute the whole map, and an inverse correspondence from space y to space x is created to recover a higher dimensional point from its lower dimensional representation.", "Hence, any new point in belonging to space x can be compressed on space y by solving the following equation: {tilde over (y)}=argmintϵynd(A1(μx(P,m)),A2(μy(Q,t))) (Equation 2) and any new point t belonging to space y can be decompressed on space x by solving the following equation: {tilde over (x)}=argminmϵxnd(A1(μx(P,m)),A2(μy(Q,t))) (Equation 3) where μx(P,m) and μy(Q,t) are the distance vectors between the points of BiMap and the new points in the corresponding respective spaces, BiMap being a pair of points, BiMap=(P,Q), solving equation 1.Depending on the phase in the nodes 140 and/or 150 are, the compression method can act in three different ways.", "In a learning phase, it can act as an input data pre-processing to let the network process data from a domain with less dimensions, thus saving both memory and computational power.", "In an inference phase, after the learning phase, it can act either as an internode feedforward (FF) and feedback (FB) data compression or as a node output classifier.", "When acting as an internode FF and FB data compression, the compression method is used to compress FF outputting from a lower level node and decompress the feedback outputting from a higher level one.", "When acting as a node output classifier, the compression method helps to visualize the learning dynamics within a node, thus to help the human qualitative interpretation of the information stored in it.", "In this case, the compression method acts as a clustering based classifier.", "If the architecture is in a learning phase, in a following step 24 of the computer-based method for simulating a human-like decision in an environmental context, the map of compressed data is evaluated by comparing said compressed data with different references previously memorized and tagging said map of compressed data with a label associated to one of the references.", "If the architecture in an inference phase, instead of step 24, any new attribute extracted from a derivation of a new recorded raw sound is added in a step 26 to the map of compressed data and a signal is generated indicating which human-like decision to use to correspond to the state of the human using a system using the computer-based method for simulating a human-like decision in an environmental context.", "Thus, during inference phase, the method for simulating a human-like decision can enable the architecture to perform several operations such as: evaluate a new sound, by going through the process hereby described without modifying the learned memories; infer common properties for sound that obtain similar judgments by analysing the low dimensional clustering performed by the BiMap; improve the reliability of human judgments, by highlighting unusual behaviours on the maps; generate sounds from a desired judgment; since all steps are reversible, new sounds with the expected judgments can be synthesized starting from their positions on the generated BiMap.", "Hereafter is another example of a use of the invention which explains in a few more details certain aspects of the invention.", "Virtual development methods are quickly gaining importance in the vehicle development process to cope with important business challenges: shortening time-to-market, optimising product quality, performance & value, reducing production & development costs, dealing with ever stricter emission & safety regulations.", "A particular challenge in the Engine and Powertrain field is the upcoming European “Real Driving Emissions” (RDE) regulation.", "RDE compliance requires control of vehicle exhaust emissions over a wide area of operating conditions.", "This heavily impacts the engine calibration process which was traditionally based on a fixed driving cycle.", "Virtualising part of the calibration process allows evaluation of vehicle & engine behaviour under various real-life driving conditions by running a physical or grey-box vehicle model over a virtual driving environment, operated by a virtual Driver Model.", "The invention is used in this example to develop a new external Driver Model, i.e.", "a method for simulating a human-like control behaviour, that handles acceleration/brake, clutch and gearshift in a human-like way.", "The methods of said invention are based on machine learning as it allows the model to learn from recorded data and to replicate driver's behaviour over any arbitrary route, making it suitable for RDE simulation.", "The proposed method is composed of three main phases during which the nodes of the architecture proceed to build a relation between recorded data from tests and the simulation environment.", "In a first phase, referred to as an extraction phase, the data captured by sensors, such as sensors 110, are sent to a Map Attribute Extractor.", "The map attribute extractor can either have as input the recorded electronic control unit (ECU) data along with the global positioning system (GPS) position or only GPS points to produce the attributes of the route connecting them.", "The first case prepares the input in order to learn a real driver's behaviour from data while the second one is necessary to extrapolate the learned behaviour over new routes.", "In a second phase, referred to as a learning phase, captured data are inputted into a model to learn the real driver behaviour on the driven route and generalize it in order to replicate the behaviour over new routes.", "At this stage BiMap are used to learn real driver behaviour in the environment by sensing ECU and GPS data.", "In an inference stage BiMap generate the expected human behaviour in new environments.", "In a third module, referred to as an inference phase, a Functional Mock-up Unit (FMU) controller cooperating in closed loop with the simulation environment uses the model build during the learning phase to implement the driver longitudinal behaviour by acting, in a human feasible way, on the car controls (gear-shift and, pedals).", "This example exhibits an artificial intelligence driver, which learns real driver behaviour on recorded routes and generalize it on arbitrary routes.", "The driver model exhibits human-like driving behaviour both on vehicle pedals and gear selection, thus it is suitable to be used in simulating emissions.", "The present invention may be realized on a processor system.", "The processing system may include a computing device or processing engine, e.g.", "a microprocessor or an FPGA.", "Any of the methods described above according to embodiments of the present invention or claimed may be implemented in a processing system.", "Such a processing system can include at least one customizable or programmable processor coupled to a memory subsystem that includes at least one form of memory, e.g., RAM, ROM, and so forth.", "It is to be noted that the processor or processors may be a general purpose, or a special purpose processor, and may be for inclusion in a device, e.g.", "a chip that has other components that perform other functions.", "Thus, one or more aspects of the method according to embodiments of the present invention can be implemented in digital electronic circuitry, or in computer hardware, firmware, software, or in combinations of them.", "The processing system may include a storage subsystem that has at least one disk drive and/or CD-ROM drive and/or DVD drive.", "In some implementations, a display system, a keyboard, and a pointing device may be included as part of a user interface subsystem to provide for a user to manually input information, such as parameter values.", "More elements such as network connections, interfaces to various devices, and so forth that allow connection to different types of physical sensors may be included.", "The various elements of the processing system may be coupled in various ways, including via a bus subsystem, for simplicity as a single bus, but which will be understood to those in the art to include a system of at least one bus.", "The memory of the memory subsystem may at some time hold part or all of a set of instructions that when executed on the processing system implement the steps of the method embodiments described herein.", "The present invention also includes a computer program product which provides the functionality of any of the methods according to the present invention when executed on a computing device, e.g.", "on a processor of the kind described above.", "Software according to the present invention, when executed on a processing engine, can contain code segments that provide a Perceptual/Cognitive architecture with artificial memory for interacting with dynamic behaviours of a tool and an operator, wherein Perceptual/Cognitive architecture is based on a Memory Prediction Framework implementation having structures and mechanisms for abstraction and generalization and optionally learning, the Memory Prediction Framework implementation comprising an enhanced artificial hierarchical memory system.", "The software may be adapted to co-operate with a pre-processing stage.", "The software, when executed, may be adapted to provide a prediction about input operator commands based on temporal events management and to describe input data from physical sensors in terms of primitives and recurrent patterns.", "The present invention also includes a computer program product having software according to the present invention, which when executed on a processing engine, can contain code segments that provide a Perceptual/Cognitive architecture with artificial memory for interacting with dynamic behaviours of a tool and an operator, wherein the Perceptual/Cognitive architecture is based on a Memory Prediction Framework implementation having structures and mechanisms for abstraction and generalization and optionally learning, the memory Prediction Framework implementation comprising an enhanced artificial hierarchical memory system.", "The software may be adapted to cooperate with a pre-processing stage, the software being adapted to describe input data from physical sensors in terms of primitives and recurrent patterns.", "The software may be adapted to allow feed-forward and feed-back signal flows and to develop the correspondence between the feed-forward and feed-back signal flows as a measure of a context check.", "The present invention also includes a computer program product which includes software according to the present invention, which can contain code segments that provide A Perceptual/Cognitive architecture with artificial memory for interacting with dynamic behaviours of a tool and an operator when executed on a processing engine.", "The architecture can be based on a Memory Prediction Framework implementation having structures and the software may be adapted to provide mechanisms for abstraction and generalization and optionally learning, the memory Prediction Framework implementation comprising an enhanced artificial hierarchical memory system.", "The software may be adapted to cooperate with a pre-processing stage, the software being adapted to describe input data from physical sensors in terms of primitives and recurrent patterns, the software being adapted to output a compressed higher level information on the behaviour of the tool and/or operator based on inputs from the physical sensors.", "The above software may be adapted for use with a Physical I/O Layer, an Enhanced hierarchical Memory, a Time Master, a Context Check, a Supervised Gating, a System Control Unit, and a User Control I/O Layer.", "The software can be adapted to translate physical sensor inputs without modifying the information content to a format manageable by the Enhanced hierarchical Memory.", "The software can be adapted to be taught and to recognize, and predict sequences of input patterns received from the Physical I/O Layer.", "The software can be adapted to output a compressed higher level information based on the physical sensor inputs received by the Physical I/O Layer.", "While the invention has been illustrated and described in detail in the drawings and foregoing description, such illustration and description are to be considered illustrative or exemplary and not restrictive; the invention is not limited to the disclosed embodiments.", "Other variations to the disclosed embodiments can be understood and effected by those skilled in the art in practising the claimed invention, from a study of the drawings, the disclosure, and the appended claims.", "For example, a single unit may fulfil the functions of several items recited in the claims.", "Any reference signs in the claims should not be construed as limiting the scope.", "For example in embodiments of the present invention modelling actions can be as “paths” or “sequences” employing Markov chains, whereby such embodiments of HTMs can “follow” just one path.", "The invention further provides for an architecture, being developed adhering to the Memory Prediction Framework (MPF) theory, in particular a system, based on the hMPF, developed to tackle a particular classification/prediction problem, having as its main processing element a artificial brain is provided.", "The artificial brain, in turn, might comprise a number of processing nodes organized in layers and communicating each other by means of feed-forward (FF), feed-back (FB), and prediction signals.", "These signals are essentially Probability Density Functions (PDFs) expressing the likelihood for a particular input pattern to be a consequence of a particular world cause.", "The whole system might further check the status of the hierarchical network by means of context check signals also provided as outputs to the network." ] ]
Patent_15874293
[ [ "III-V FIN Generation By Lateral Growth On Silicon Sidewall", "A method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate; causing a nucleation of a III-V material in a sidewall of the structure defined by the silicon material; adjusting a growth condition to facilitate a first growth rate of the III-V material in directions along a surface of the sidewall and a second growth rate of the III-V material in a direction laterally from the surface of the sidewall, wherein the second growth rate is less than the first growth rate; and processing the silicon material and the III-V material to form a fin." ], [ "1.A method, comprising: forming a mandrel on a buried oxide layer on a silicon substrate, the forming of the mandrel being by a facet-selective wet etch of a (110) silicon material, the mandrel having at least one sidewall perpendicular to a surface of the buried oxide layer, the sidewall having a top surface extending in a <110> direction orthogonal to the surface of the buried oxide layer and a side surface extending in a <111> direction parallel to a surface of the buried oxide layer; disposing an oxide mask on the at least one sidewall of the mandrel in the <111> direction to define at least one seed area; causing a growth of a III-V material on the at least one sidewall of the mandrel from the at least one seed area in the <110> and <112> directions and in the <111> direction; adjusting a growth condition to facilitate a faster growth rate of the III-V material in the <110> direction and a slower growth rate in the <111> direction; processing the (110) silicon material and the III-V material to form a fin; and disposing a gate stack over the formed fin.", "2.The method of claim 1, wherein causing a growth of a III-V material on the at least one sidewall of the mandrel from the at least one seed area in the <110> direction and in the <111> direction comprises depositing the III-V material on the at least one seed area at a preselected temperature and pressure.", "3.The method of claim 1, wherein after growth of the III-V material on the at least one sidewall of the mandrel, the III-V is substantially defect-free.", "4.The method of claim 1, further comprising removing the mandrel after disposing the gate stack over the formed fin, the removing of the mandrel being by subjecting the mandrel to a selective wet-etch or dry-etch technique.", "5.The method of claim 1, further comprising forming a source region and a drain region in the buried oxide layer proximate opposing ends of the gate stack.", "6.The method of claim 5, wherein forming a source region and a drain region in the buried oxide layer comprises forming n+ source and drain regions via epitaxially grown n+ III-V material.", "7.The method of claim 5, wherein forming a source region and a drain region in the buried oxide layer comprises forming n+ source and drain regions via ion implantation into the III-V material.", "8.The method of claim 1, wherein processing the (110) silicon material and the III-V material to form a fin comprises disposing a field oxide layer over the silicon material and the III-V material and planarizing the field oxide layer and the III-V material.", "9.The method of claim 8, further comprising removing the field oxide layer by applying a wet-etch technique to the planarized field oxide layer.", "10.The method of claim 1, wherein the III-V material comprises a material selected from the group consisting of gallium arsenide (GaAs), aluminum arsenide (AlAs), indium gallium arsenide (InGaAs), indium phosphide (InP), gallium phosphide (GaP), gallium nitride (GaN), gallium arsenide phosphide (GaAsP), gallium indium arsenide antimony phosphide (GaInAsSbP), aluminum gallium arsenide (AlGaAs), aluminum gallium indium arsenide (AlGaInAs), indium arsenide (InAs), indium gallium phosphide (InGaP), indium arsenide antimony phosphide (InAsSbP), indium gallium aluminum phosphide (InGaAlP), and combinations of the foregoing." ], [ "<SOH> BACKGROUND <EOH>The exemplary embodiments of this invention relate generally to semiconductor devices and techniques for the fabrication thereof and, more specifically, to the fabrication of fin-type transistor devices having channels of III-V materials.", "Semiconductors and integrated circuit chips have become widely used in many products due to their decreasing cost and size.", "In the microelectronics industry there is a continued desire to reduce the size of structural features and microelectronic devices in order to provide a greater amount of circuitry on a given chip.", "Doing so generally allows for increased performance (more processing per clock cycle and less heat generated) at lower power levels and lower cost.", "However, the present technology is at or approaching atomic level scaling of certain micro-devices.", "One type of microelectronic device that is continually being reduced in size is a field effect transistor (FET), which is generally defined by a source, a gate, and a drain.", "The action of the FET depends on the flow of majority carriers along a channel that runs past the gate and between the source and drain.", "Current through the channel between the source and drain may be controlled by a transverse electric field under the gate.", "The size of a FET can be reduced by forming the channel in the shape of a fin.", "A FET employing such a channel structure may be referred to as a finFET.", "The fin-shaped channels (or “fins”) may be fabricated of, for example, germanium or III-V materials.", "Such fins may be fabricated on silicon substrates.", "The fabrication of defect-free III-V fins on a silicon substrate, however, may be difficult.", "Current III-V heterogeneous epitaxy techniques (such as aspect ratio trapping and graded buffer growth) and other deposition techniques generally utilize relatively thick buffers of III-V materials (e.g., more than several hundreds of nanometers) and tend to result in the fabricated fins having large numbers of defects." ], [ "<SOH> BRIEF SUMMARY <EOH>In one exemplary aspect, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate; causing a nucleation of a III-V material in a sidewall of the structure defined by the silicon material; adjusting a growth condition to facilitate a first growth rate of the III-V material in directions along a surface of the sidewall and a second growth rate of the III-V material in a direction laterally from the surface of the sidewall, wherein the second growth rate is less than the first growth rate; and processing the silicon material and the III-V material to form a fin.", "In another exemplary aspect, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate, the structure having at least one sidewall perpendicular to a surface of the buried oxide layer and a top surface parallel to the surface of the buried oxide layer; disposing a discontinuous oxide mask on the at least one sidewall of the structure to define at least one seed area at at least one discontinuity in the oxide mask; causing a nucleation of a III-V material in the at least one seed area; adjusting a growth condition to facilitate a first growth rate of the III-V material along the sidewall and a second growth rate of the III-V material lateral to the sidewall, wherein the second growth rate is less than the first growth rate; processing the silicon material and the III-V material to form a fin; and disposing a gate over the formed fin.", "In another exemplary aspect, a method comprises forming a mandrel on a buried oxide layer on a silicon substrate, the forming of the mandrel being by a facet-selective wet etch of a (110) silicon material, the mandrel having at least one sidewall perpendicular to a surface of the buried oxide layer, the sidewall having a top surface extending in a <110> direction orthogonal to the surface of the buried oxide layer and a side surface extending in a <111> direction parallel to a surface of the buried oxide layer; disposing an oxide mask on the at least one sidewall of the mandrel in the <111> direction to define at least one seed area; causing a growth of a III-V material on the at least one sidewall of the mandrel from the at least one seed area in the <110> and <112> directions and in the <111> direction; adjusting a growth condition to facilitate a faster growth rate of the III-V material in the <110> and <112> directions and a slower growth rate in the <111> direction; processing the (110) silicon material and the III-V material to form a fin; and disposing a gate stack over the formed fin." ], [ "CROSS REFERENCE TO RELATED APPLICATION This patent application is a divisional application of copending U.S. Patent Application Ser.", "No.", "14/876,986, filed on Oct. 7, 2015, the disclosure of which is incorporated by reference herein in its entirety.", "BACKGROUND The exemplary embodiments of this invention relate generally to semiconductor devices and techniques for the fabrication thereof and, more specifically, to the fabrication of fin-type transistor devices having channels of III-V materials.", "Semiconductors and integrated circuit chips have become widely used in many products due to their decreasing cost and size.", "In the microelectronics industry there is a continued desire to reduce the size of structural features and microelectronic devices in order to provide a greater amount of circuitry on a given chip.", "Doing so generally allows for increased performance (more processing per clock cycle and less heat generated) at lower power levels and lower cost.", "However, the present technology is at or approaching atomic level scaling of certain micro-devices.", "One type of microelectronic device that is continually being reduced in size is a field effect transistor (FET), which is generally defined by a source, a gate, and a drain.", "The action of the FET depends on the flow of majority carriers along a channel that runs past the gate and between the source and drain.", "Current through the channel between the source and drain may be controlled by a transverse electric field under the gate.", "The size of a FET can be reduced by forming the channel in the shape of a fin.", "A FET employing such a channel structure may be referred to as a finFET.", "The fin-shaped channels (or “fins”) may be fabricated of, for example, germanium or III-V materials.", "Such fins may be fabricated on silicon substrates.", "The fabrication of defect-free III-V fins on a silicon substrate, however, may be difficult.", "Current III-V heterogeneous epitaxy techniques (such as aspect ratio trapping and graded buffer growth) and other deposition techniques generally utilize relatively thick buffers of III-V materials (e.g., more than several hundreds of nanometers) and tend to result in the fabricated fins having large numbers of defects.", "BRIEF SUMMARY In one exemplary aspect, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate; causing a nucleation of a III-V material in a sidewall of the structure defined by the silicon material; adjusting a growth condition to facilitate a first growth rate of the III-V material in directions along a surface of the sidewall and a second growth rate of the III-V material in a direction laterally from the surface of the sidewall, wherein the second growth rate is less than the first growth rate; and processing the silicon material and the III-V material to form a fin.", "In another exemplary aspect, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate, the structure having at least one sidewall perpendicular to a surface of the buried oxide layer and a top surface parallel to the surface of the buried oxide layer; disposing a discontinuous oxide mask on the at least one sidewall of the structure to define at least one seed area at at least one discontinuity in the oxide mask; causing a nucleation of a III-V material in the at least one seed area; adjusting a growth condition to facilitate a first growth rate of the III-V material along the sidewall and a second growth rate of the III-V material lateral to the sidewall, wherein the second growth rate is less than the first growth rate; processing the silicon material and the III-V material to form a fin; and disposing a gate over the formed fin.", "In another exemplary aspect, a method comprises forming a mandrel on a buried oxide layer on a silicon substrate, the forming of the mandrel being by a facet-selective wet etch of a (110) silicon material, the mandrel having at least one sidewall perpendicular to a surface of the buried oxide layer, the sidewall having a top surface extending in a <110> direction orthogonal to the surface of the buried oxide layer and a side surface extending in a <111> direction parallel to a surface of the buried oxide layer; disposing an oxide mask on the at least one sidewall of the mandrel in the <111> direction to define at least one seed area; causing a growth of a III-V material on the at least one sidewall of the mandrel from the at least one seed area in the <110> and <112> directions and in the <111> direction; adjusting a growth condition to facilitate a faster growth rate of the III-V material in the <110> and <112> directions and a slower growth rate in the <111> direction; processing the (110) silicon material and the III-V material to form a fin; and disposing a gate stack over the formed fin.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS The foregoing and other aspects of exemplary embodiments are made more evident in the following Detailed Description, when read in conjunction with the attached Drawing Figures, wherein: FIG.", "1 is a perspective schematic representation of a portion of a silicon mandrel on which fins may be grown; FIG.", "2 is a perspective schematic representation of the silicon mandrel of FIG.", "1 disposed on a handle wafer comprising an insulating base substrate and an overlying buried oxide layer; FIG.", "3 is a top view of the schematic representation of FIG.", "2; FIGS.", "4 and 5 are perspective schematic representations of another exemplary embodiment of a silicon mandrel disposed on a handle substrate; FIGS.", "6-9 are perspective schematic representations of other exemplary embodiments of a silicon mandrel disposed on a handle substrate; FIG.", "10 is perspective schematic representation of the silicon mandrel of FIG.", "2 having fins laterally grown on opposing sidewalls; FIG.", "11 is a top view of the schematic representation of FIG.", "10; FIG.", "12 is a perspective schematic representation of the mandrel and fins of FIG.", "10 covered by a field oxide layer; FIG.", "13 is a perspective schematic representation of the mandrel, fins, and field oxide layer of FIG.", "12 polished down to an upper surface of a stop layer on the mandrel; FIG.", "14 is a perspective schematic representation of a mandrel/fin arrangement having gate stacks disposed thereon; FIG.", "15 is a top view of the schematic representation of FIG.", "14; FIG.", "16 is a perspective schematic representation of the mandrel/fin arrangement and gate stacks of FIG.", "14 having source/drain regions disposed thereon; FIG.", "17 is a top view of the schematic representation of FIG.", "16; FIG.", "18 is a perspective schematic representation of an exemplary embodiment of fins and gate stacks without a mandrel; FIG.", "19 is a top view of the schematic representation of FIG.", "18; FIG.", "20 is a top view of the schematic representation of FIG.", "18 having source/drain regions disposed on the fins; FIG.", "21 is a block diagram of various electronic devices and apparatuses that may be suitable for use in forming the structures described herein; and FIG.", "22 is a logic flow diagram that illustrates the operation of an exemplary method, and a result of execution of computer program instructions embodied on a computer readable memory, in accordance with an exemplary embodiment of the manufacture of structures described herein.", "DETAILED DESCRIPTION The word “exemplary” is used herein to mean “serving as an example, instance, or illustration.” Any embodiment described herein as “exemplary” is not necessarily to be construed as preferred or advantageous over other embodiments.", "All of the embodiments described in this Detailed Description are exemplary embodiments provided to enable persons skilled in the art to make or use the invention and not to limit the scope of the invention which is defined by the claims.", "As used herein, the term “III-V” refers to inorganic crystalline compound semiconductors having at least one Group III element and at least one Group V element.", "Exemplary III-V materials for use in the structures and methods described herein include, but are not limited to, gallium arsenide (GaAs), aluminum arsenide (AlAs), gallium phosphide (GaP), gallium nitride (GaN), gallium arsenide phosphide (GaAsP), gallium indium arsenide antimony phosphide (GaInAsSbP), aluminum gallium arsenide (AlGaAs), aluminum gallium indium arsenide (AlGaInAs), indium arsenide (InAs), indium gallium phosphide (InGaP), indium gallium arsenide (InGaAs), indium arsenide antimony phosphide (InAsSbP), indium gallium aluminum phosphide (InGaAlP), and combinations of the foregoing.", "As shown in FIG.", "1, one exemplary embodiment of a structure for use in fabricating a finFET or a fin-type transistor device having active areas (such as channels) formed by III-V material(s) is designated generally by the reference number 100.The structure comprises a mandrel and is hereinafter referred to as “mandrel 100.” The mandrel 100 can comprise silicon or other insulative material.", "In some embodiments illustrated herein, the mandrel 100 is a silicon substrate of silicon-on-insulator (SOI) material or bulk material having a (110) crystal configuration.", "Because of the (110) configuration of the silicon forming the mandrel.", "100, the silicon of the mandrel 100 would have a top surface 105 having crystal orientations of {110} and sidewalls 110 having crystal orientations of {111}.", "Referring to FIGS.", "2-22, exemplary embodiments of methods of fabricating a finFET or a fin-type device having one or more fins using the mandrel and comprising a III-V material are shown.", "As shown in FIGS.", "2 and 3, the mandrel 100 may be disposed on a handle wafer 115 comprising an insulating silicon base substrate 120 having an overlying buried oxide (BOX) layer 125, with the mandrel 100 being disposed directly on the BOX layer 125.The mandrel 100 may comprise the silicon having the (110) configuration with a silicon etch mask/chemical mechanical polish (CMP) stop layer 130 (hereinafter “stop layer 130”) disposed on the top surface 105 (in the <110> direction) and one or more sidewall oxide masks 135 (or a discontinuous sidewall oxide mask 135) disposed on portions of the opposing sidewalls in the <111> directions.", "The stop layer 130 can comprise a silicon nitride (SiNx) such as, for example, SiN, Si3N4, or the like, or SiO2, or Al2O3.The sidewall oxide masks 135 can comprise any suitable oxide such as, for example, SiO2, as well as other materials such as silicon nitrides, and are deposited on the sidewall by any suitable deposition technique or by thermal oxidation.", "The mandrel 100 may be formed by facet-selective wet etch on a (110) crystalline configuration of the SOI material or the bulk material such that the opposing sidewalls of the mandrel 100 are <111> faceted sidewalls that are perpendicular to an upper surface 140 of the BOX layer 125.The BOX layer 125 may be formed by implantation of oxide ions.", "A seed area 145 is defined on each sidewall of the mandrel 100 by a gap, break, or discontinuity between sidewall oxide masks 135.If only one sidewall oxide mask 135 is employed, the seed area 145 may be defined by an opening in the sidewall oxide mask 135 or a through hole extending through the material of the sidewall oxide mask 135 down to the sidewall of the mandrel 100.The seed area 145 allows for the generation of nucleations in the III-V material forming the fin in a controlled manner (and without a buffer region between the III-V material and the material of the mandrel 100).", "In another exemplary embodiment, as shown in FIGS.", "4 and 5, a (112) oriented silicon surface wafer can be used to form the <111> direction sidewall.", "As shown in FIG.", "4, the insulating silicon base substrate 120 having the BOX layer 125 may be provided with an overlying layer of (112) silicon 127 on the BOX layer 125 to form the mandrel 100 of (112) silicon.", "The stop layer 130 may be disposed on the overlying layer of (112) silicon 127.The stop layer 130 can comprise a silicon nitride (SiNx) such as, for example, SiN, Si3N4, or the like, or SiO2, or Al2O3.The overlying layer of (112) silicon 127 may be patterned and masked.", "As shown in FIG.", "5, mandrels 100 that are parallel to the <112> direction may be formed by a dry-etch technique (e.g., XeF2) or an anisotropic wet-etching of the silicon using tetramethylammonium hydroxide (TMAH) or potassium hydroxide (KOH).", "In such an embodiment, the silicon mandrel 100 is formed with a vertical sidewall that is normal to the <111> direction and that has an atomically flat surface due to the nature of facet-selective etching.", "Another exemplary embodiment is shown in FIGS.", "6-9.As shown in FIG.", "6, the mandrel 100 may be formed using (110) or (112) silicon directly on the silicon base substrate 120 using any suitable anisotropic wet-etch technique (e.g., using TMAH or KOH).", "As shown in FIG.", "7, SiO2 is deposited around the mandrel 100 to form a bottom oxide layer 131a and over the mandrel 100 and the bottom oxide layer 131a to form a top oxide layer 131b.", "As shown in FIG.", "8, the top oxide layer 131b is planarized down to the stop layer 130 and the bottom oxide layer 131a.", "As shown in FIG.", "9, the bottom oxide layer 131a below the stop layer 130 is etched to expose the sidewalls of the mandrel 100.Sidewall oxide masks 135 may be disposed on the sidewalls to form the seed areas 145.Referring now to FIGS.", "10 and 11, the III-V material is laterally grown from the seed areas 145 on the sides of the mandrel 100 to form the active areas.", "Although the III-V material may be grown from any of the seed areas 145 described above, FIGS.", "10 and 11 are depicted to show lateral growth from the seed areas 145 of the mandrel 100 and handle wafer 115 of FIG.", "2.Since only a small portion of the silicon of the sidewall of the mandrel 100 is exposed to the III-V material in the seed area 145, growth of the III-V material can be from a single nucleus of III-V material deposited on the (110) configuration of the SOI material or the bulk material at a preselected temperature and pressure to initiate the growth, thereby allowing for high quality growth to be achieved due to the substantial absence of defects that can be generated when two growth fronts merge.", "Conditions (e.g., temperature, pressure, and the like) are selected and adjusted such that a growth rate of the III-V material in the <110> direction is faster than a growth rate in the <111> direction, which results in a structure on each side of the mandrel 100 to define fins 150, such fins 150 having a height h (FIG.", "10) that is substantially greater than a thickness t (FIG.", "11).", "As shown in FIG.", "12, upon growth of the fins 150, a field oxide layer 155 (or equivalent material for CMP) can be disposed on the BOX layer 125 and over the fins 150 and mandrels 100.The field oxide layer 155 can comprise any suitable oxide material (e.g., silicon dioxide, spin-on-glass, or any dielectric material that can be selectively polished to the dielectric on the mandrels 100) for passivating and protecting the surfaces of the BOX layer 125, the fins 150, and the mandrels 100.As shown in FIG.", "13, a CMP process can be carried out on the field oxide layer 155 to planarize the field oxide and the fins 150 down to the surface of the stop layer 130 on the mandrel 100.As shown in FIGS.", "14 and 15, the portions of the field oxide layer 155 disposed on the BOX layer 125 and below the stop layer 130 (and not removed by the CMP process) can be removed by a wet-etch technique such as acid wash with hydrofluoric acid (HF).", "Also, portions of the sidewall oxide mask 135 may be also removed.", "After removal of the field oxide layer 155, one or more gate stacks 160 are formed over the fins 150 and the mandrel 100.In embodiments in which the gate stack 160 is formed as a replacement metal gate (RMG), a dummy gate structure is formed from hardmask material and sacrificial gate material, the dummy gate structure being used as a placeholder which is subsequently removed (e.g., by reactive ion etching) and replaced with a metal gate structure (e.g., using any suitable metal deposition process).", "In embodiments in which the gate stack 160 is formed for gate-first flow, both metal gate material and polysilicon gate material may be deposited, and the polysilicon gate material and portions of the metal gate material are subtractively etched.", "In either embodiment of formation of the gate stack 160, the gate stack 160 is aligned with the laterally grown III-V material of the fins 150.The gate stack 160 may be deposited over the III-V material defining the fins 150 on the sides of the mandrel 100 as well as over the top surface of the planarized stop layer 130 such that the gate stack 160 is defined by lower gate portions 162 extending from the sides of the fins 150 as well as an upper gate portion 164 extending from upper surfaces of the lower gate portions 162 and across the III-V material and the stop layer 130 on the mandrel 100.As shown in FIGS.", "16 and 17, n+ source and drain regions 170 may be formed on the sides of the III-V material of the fins 150.The source and drain regions 170 may be formed via epitaxially grown n-type doped III-V material or doping from ion implantation into the III-V material.", "As can be seen in FIG.", "17, the III-V material may be continuous in the <112> direction along the sides of the mandrel 100, whereas the source and drain regions 170 may be discontinuous in the <112> directions along the sides of the III-V material of the fins 150 and separated by the lower gate portions 162.As shown in FIGS.", "18 and 19, in another exemplary embodiment, the mandrel 100 can be removed prior to the formation of the gate stack 160 over the fins 150.In such an embodiment, the mandrel 100 may be removed by subjecting the mandrel 100 to an anisotropic selective wet-etch technique (e.g., TMAH, KOH, ammonium hydroxide (NH4OH), or the like) or a dry-etch technique (e.g., XeF2 or the like).", "Upon removal of the mandrel 100, the gate stack 160 is formed laterally over and between the parallel fins 150 previously formed on each opposing side of the mandrel 100.In this embodiment, lower gate portions 162 are not only formed to extend outward from the fins 150, but also between the fins 150.Also, the upper gate portion 164 may be comprised of two portions.", "As shown in FIG.", "20, n+ source and drain regions 170 may be formed on both sides of the III-V material of the fins 150.The source and drain regions 170 may be formed via an epitaxy process or by ion implantation.", "As can be seen in FIG.", "20, the III-V material may be continuous in the <112> direction under the upper gate portions 164, whereas the source and drain regions 170 may be discontinuous in the <112> directions along the sides of the III-V material of the fins 150 and separated by the lower gate portions 162.Referring now to FIG.", "21, a simplified block diagram of various electronic devices and apparatuses that are suitable for use in practicing the exemplary embodiments described herein is shown.", "For example, a computer 1510 may be used to control one or more of the processes as described above.", "The computer 1510 includes a controller, such as a computer or a data processor (DP) 1514 and a computer-readable memory medium embodied as a memory (MEM) 1516 that stores a program of computer instructions (PROG) 1518.The PROG 1518 includes program instructions that, when executed by the associated DP 1514, enable the various electronic devices and apparatuses to operate in accordance with exemplary embodiments.", "That is, various exemplary embodiments may be implemented at least in part by computer software executable by the DP 1514 of the computer 1510, or by hardware, or by a combination of software and hardware (and firmware).", "The computer 1510 may also include dedicated processors, for example a processor 1515 that controls the conditions for growth of the III-V material from the seed areas 145.The computer readable MEM 1516 may be of any type suitable to the local technical environment and may be implemented using any suitable data storage technology, such as semiconductor based memory devices, flash memory, magnetic memory devices and systems, optical memory devices and systems, fixed memory, and removable memory.", "The DP 1514 may be of any type suitable to the local technical environment, and may include one or more of general purpose computers, special purpose computers, microprocessors, digital signal processors (DSPs), and processors based on a multicore processor architecture, as non-limiting examples.", "The exemplary embodiments, as discussed herein and as particularly described with respect to exemplary methods, may be implemented in conjunction with a program storage device (e.g., at least one memory) readable by a machine, tangibly embodying a program of instructions (e.g., a program or computer program) executable by the machine for performing operations.", "The operations comprise utilizing the exemplary embodiments of the method.", "Based on the foregoing, it should be apparent that various exemplary embodiments provide methods to generate fins by substantially lateral growth on a silicon sidewall.", "FIG.", "22 is a logic flow diagram that illustrates the operation of one exemplary embodiment of a method 1600 (and a result of an execution of computer program instructions (such as PROG 1518)), in accordance with the exemplary embodiments.", "In accordance with these exemplary embodiments, at block 1610, a mandrel of (110) silicon is disposed on a handle wafer.", "At block 1620, a stop layer of SiNx is disposed on the silicon of the top of the mandrel (in the <110> direction), and an oxide mask is disposed on portions of the sidewalls of the mandrel (in the <111> directions).", "At block 1630, III-V material is grown from portions of the sidewalls not covered by the oxide mask, the grown material forming fins.", "Growth of the fins occurs in both the <110> and <111> directions from nucleation sites.", "At block 1640, the fins and the mandrel are covered with a field oxide layer.", "Processing of the field oxide layer using CMP is carried out at block 1650 to planarize the field oxide layer and the fins down to the stop layer.", "At block 1660, the remaining field oxide layer and portions of the sidewall oxide mask are removed.", "At 1665, a decision is made as to whether the mandrel is desired in the final finFET or fin-type device.", "If the mandrel is not desired, the mandrel is removed at block 1670, and control passes to block 1680 to form a gate stack over the fins.", "If the mandrel is desired at 1665, control passes directly to block 1680.At block 1690, source/drain regions are formed adjacent to the fins.", "The various blocks shown in FIG.", "16 may be viewed as method steps, and/or as operations that result from operation of computer program code, and/or as a plurality of coupled logic circuit elements constructed to carry out the associated function(s).", "In one exemplary embodiment, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate; causing a nucleation of a III-V material in a sidewall of the structure defined by the silicon material; adjusting a growth condition to facilitate a first growth rate of the III-V material in directions along a surface of the sidewall and a second growth rate of the III-V material in a direction laterally from the surface of the sidewall, wherein the second growth rate is less than the first growth rate; and processing the silicon material and the III-V material to form a fin.", "The method may further comprise forming a source region and a drain region on opposing sides of the fin and forming a gate extending across the fin between the source region and the drain region.", "Forming a source region and a drain region may comprise doping using one or more of an epitaxy process and an ion implantation process.", "Processing the silicon material and the III-V material to form a fin may comprise disposing an oxide layer over the structure defined by a silicon material and the buried oxide layer, planarizing the oxide layer and the fin, and removing excess oxide layer using a wet-etch technique (e.g., an acid wash).", "The method may further comprise removing the structure defined by a silicon material.", "The silicon material may be either a (110) silicon material or a (112) silicon material.", "In another exemplary embodiment, a method comprises providing a structure defined by a silicon material on a buried oxide layer of a substrate, the structure having at least one sidewall perpendicular to a surface of the buried oxide layer and a top surface parallel to the surface of the buried oxide layer; disposing a discontinuous oxide mask on the at least one sidewall of the structure to define at least one seed area at at least one discontinuity in the oxide mask; causing a nucleation of a III-V material in the at least one seed area; adjusting a growth condition to facilitate a first growth rate of the III-V material along the sidewall and a second growth rate of the III-V material lateral to the sidewall, wherein the second growth rate is less than the first growth rate; processing the silicon material and the III-V material to form a fin; and disposing a gate over the formed fin.", "Providing a structure defined by a silicon material on a buried oxide layer of a substrate may comprise forming a mandrel by a facet-selective wet etch of the silicon material.", "The method may further comprise forming the buried oxide layer by ion implantation.", "Causing a nucleation of a III-V material in the at least one seed area may comprise depositing the III-V material on the seed area at a preselected temperature and pressure to initiate growth of III-V material.", "The method may further comprise forming a source region and a drain region in the buried oxide layer proximate opposing ends of the gate.", "Forming a source region and a drain region in the buried oxide layer may comprise forming n+ source and drain regions via epitaxially grown n+ III-V material and/or by ion implantation into the III-V material.", "Processing the silicon material and the III-V material to form a fin may comprise disposing a field oxide layer over the silicon material and the III-V material and planarizing the field oxide layer and the III-V material down to a stop layer of a silicon nitride on the top surface of the sidewall of the structure.", "The method may further comprise removing the structure defined by the silicon material after forming the gate over the formed fin.", "The silicon material may be either a (110) silicon material or a (112) silicon material.", "In another exemplary embodiment, a method comprises forming a mandrel on a buried oxide layer on a silicon substrate, the forming of the mandrel being by a facet-selective wet etch of a (110) silicon material, the mandrel having at least one sidewall perpendicular to a surface of the buried oxide layer, the sidewall having a top surface extending in a <110> direction orthogonal to the surface of the buried oxide layer and a side surface extending in a <111> direction parallel to a surface of the buried oxide layer; disposing an oxide mask on the at least one sidewall of the mandrel in the <111> direction to define at least one seed area; causing a growth of a III-V material on the at least one sidewall of the mandrel from the at least one seed area in the <110> and <112> directions and in the <111> direction; adjusting a growth condition to facilitate a faster growth rate of the III-V material in the <110> and <112> directions and a slower growth rate in the <111> direction; processing the (110) silicon material and the III-V material to form a fin; and disposing a gate stack over the formed fin.", "Causing a growth of a III-V material on the at least one sidewall of the mandrel from the at least one seed area in the <110> direction and in the <111> direction may comprise depositing the III-V material on the at least one seed area at a preselected temperature and pressure.", "After growth of the III-V material on the at least one sidewall of the mandrel, the III-V may be substantially defect-free.", "The method may further comprise removing the mandrel after disposing the gate stack over the formed fin, the removing of the mandrel being by subjecting the mandrel to a selective wet-etch or dry-etch technique.", "The III-V material may comprise a material selected from the group consisting of gallium arsenide (GaAs), aluminum arsenide (AlAs), indium gallium arsenide (InGaAs), indium phosphide (InP), gallium phosphide (GaP), gallium nitride (GaN), gallium arsenide phosphide (GaAsP), gallium indium arsenide antimony phosphide (GaInAsSbP), aluminum gallium arsenide (AlGaAs), aluminum gallium indium arsenide (AlGaInAs), indium arsenide (InAs), indium gallium phosphide (InGaP), indium arsenide antimony phosphide (InAsSbP), indium gallium aluminum phosphide (InGaAlP), and combinations of the foregoing.", "The foregoing description has provided by way of exemplary and non-limiting examples a full and informative description of the best method and apparatus presently contemplated by the inventors for carrying out various exemplary embodiments.", "However, various modifications and adaptations may become apparent to those skilled in the relevant arts in view of the foregoing description, when read in conjunction with the accompanying drawings and the appended claims.", "However, all such and similar modifications will still fall within the scope of the teachings of the exemplary embodiments.", "Furthermore, some of the features of the preferred embodiments could be used to advantage without the corresponding use of other features.", "As such, the foregoing description should be considered as merely illustrative of the principles, and not in limitation thereof." ] ]
Patent_15874294
[ [ "METHOD AND SYSTEM FOR SELECTIVE PAGING OF WIRELESS DEVICES USING A CELLULAR BROADCAST SERVICE", "Aspects of the subject disclosure may include, for example, determining a request to transfer data to a group of wireless communication devices within an area.", "Wireless base stations of a wireless mobility network are identified, responsive to the request, wherein the wireless base stations provide wireless communication services within the area, including a Multimedia Broadcast Multicast Service (MBMS) service.", "A wireless transmission is facilitated of a first broadcast message by the wireless base stations, wherein the first broadcast message identifies the group of wireless communication devices.", "The broadcast message is transmitted by way of the MBMS service of the wireless communication services.", "The first broadcast message initiates a state transition to an active state for a plurality of wireless communication devices of the group of wireless communication devices configured in an idle state.", "Other embodiments are disclosed." ], [ "1.A method comprising: identifying, by a processing system including a processor, a plurality of wireless base stations that provide wireless communication services within a geographical region, wherein the wireless communication services comprise a Multimedia Broadcast Multicast Service (MBMS) service; and facilitating, by the processing system, a transmission of a broadcast message and a subsequent data transfer by the plurality of wireless base stations via the MBMS service to a plurality of wireless communication devices, wherein the broadcast message identifies the plurality of wireless communication devices, wherein the broadcast message initiates a state transition to an active state for a group of wireless communication devices of the plurality of wireless communication devices configured in an idle state at a time of the transmission of the broadcast message, wherein the plurality of wireless communication devices receive the data transfer without responding to the broadcast message, wherein, in accordance with receiving the broadcast message, a first wireless communication device of the group of wireless communication devices transitions to the active state after a first delay period and a second wireless communication device of the group of wireless communication devices transitions to the active state after a second delay period different from the first delay period.", "2.The method of claim 1, further comprising: detecting, by the processing system, a request to perform the data transfer; and determining, by the processing system, the geographical region based on the request.", "3.The method of claim 1, further comprising selecting, by the processing system, the MBMS service to perform the data transfer.", "4.The method of claim 1, wherein each device of the group of wireless communication devices transitions to the active state after a delay period uniquely associated with that device.", "5.The method of claim 1, wherein the group of wireless communication devices comprises a plurality of subgroups of wireless communication devices, and wherein each device of a given subgroup of wireless communication devices transitions to the active state after a delay period associated with that subgroup.", "6.The method of claim 1, wherein the first wireless communication device determines the first delay period.", "7.The method of claim 6, wherein the broadcast message includes information used by the first wireless communication device to determine the first delay period.", "8.The method of claim 6, wherein the first wireless communication device updates the first delay period in accordance with receiving the broadcast message, the first wireless communication device thereby transitioning to the active state in accordance with a subsequent broadcast message after an updated first delay period different from the first delay period.", "9.The method of claim 1, wherein the transmission of the broadcast message is repeated according to a schedule.", "10.The method of claim 1, wherein a wireless communication device of the plurality of wireless communication devices located outside the geographical region during the transmission of the broadcast message receives the broadcast message upon returning to the geographical region.", "11.A device comprising: a processing system including a processor; and a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations comprising: detecting a data transfer request to transfer data to a plurality of wireless communication devices located in a geographical region; identifying a plurality of wireless base stations that provide wireless communication services within the geographical region, wherein the wireless communication services comprise a Multimedia Broadcast Multicast Service (MBMS) service; facilitating a transmission of a broadcast message by the plurality of wireless base stations via the MBMS service to the plurality of wireless communication devices, wherein the broadcast message identifies the plurality of wireless communication devices, wherein the broadcast message initiates a state transition to an active state for a group of wireless communication devices of the plurality of wireless communication devices configured in an idle state at a time of the transmission of the broadcast message, wherein, in accordance with receiving the broadcast message, a first wireless communication device of the group of wireless communication devices transitions to the active state after a first delay period and a second wireless communication device of the group of wireless communication devices transitions to the active state after a second delay period different from the first delay period; and facilitating the data transfer by the plurality of wireless base stations via the MBMS service to the plurality of wireless communication devices, wherein the plurality of wireless communication devices receive the data transfer without responding to the broadcast message.", "12.The device of claim 11, wherein the operations further comprise determining the geographical region based on the request.", "13.The device of claim 11, wherein the operations further comprise selecting the MBMS service to perform the data transfer.", "14.The device of claim 11, wherein each device of the group of wireless communication devices transitions to the active state after a delay period uniquely associated with that device.", "15.The device of claim 11, wherein the group of wireless communication devices comprises a plurality of subgroups of wireless communication devices, and wherein each device of a given subgroup of wireless communication devices transitions to the active state after a delay period associated with that subgroup.", "16.A machine-readable medium comprising executable instructions that, when executed by a processing system including a processor, facilitate performance of operations comprising: detecting a data transfer request to transfer data to a plurality of wireless communication devices located in a geographical region; identifying a plurality of wireless base stations that provide wireless communication services within the geographical region; facilitating a transmission of a broadcast message by the plurality of wireless base stations to the plurality of wireless communication devices, wherein the broadcast message identifies the plurality of wireless communication devices, wherein the broadcast message initiates a state transition to an active state for a group of wireless communication devices of the plurality of wireless communication devices configured in an idle state at a time of the transmission of the broadcast message, wherein, in accordance with receiving the broadcast message, at least one wireless communication device of the group of wireless communication devices transitions to the active state after a delay period; and facilitating the data transfer by the plurality of wireless base stations to the plurality of wireless communication devices, wherein the wireless communication devices receive the data transfer without responding to the broadcast message.", "17.The machine-readable medium of claim 16, wherein the wireless communication services comprise a Multimedia Broadcast Multicast Service (MBMS) service, and wherein the transmission of the broadcast message and the data transfer are performed via the MBMS service.", "18.The machine-readable medium of claim 16, wherein each device of the group of wireless communication devices transitions to the active state after a delay period uniquely associated with that device.", "19.The machine-readable medium of claim 16, wherein the at least one wireless communication device determines the delay period.", "20.The machine-readable medium of claim 19, wherein the broadcast message includes information used by the at least one wireless communication device to determine the delay period." ], [ "<SOH> BACKGROUND <EOH>A Long Term Evolution (LTE) capable, mobile communication device establishes connections and receives high-speed mobility services by a process that includes attachment to a Mobility Management Entity (MME) of an Evolved Packet Core (EPC) portion of a wireless mobility network.", "In a Connected state, the mobile device sends and/or receives data by way of a radio bearer established through a base station of the mobility network.", "While not engaged in an active exchange of data packets, the mobile device generally reverts to an idle state.", "Namely, the mobile device is released when an inactivity timer has been exceeded.", "For mobile devices in the idle state, a Serving Gateway (SGW) of the EPC terminates the downlink data path to the mobile device.", "The SGW also triggers a downlink data notification towards the MME that results in the MME paging of a given mobile device in response to a reception of downlink data directed to the idle mobile device.", "In traditional paging, the MME individually pages the idle mobile device to indicate a presence of pending downlink data traffic.", "The paging message triggers the mobile device to reply with a service request.", "Processing of the service request transitions the mobile device to a connected state, allowing the mobile device to receive the user data via a unicast packet flow." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Reference will now be made to the accompanying drawings, which are not necessarily drawn to scale, and wherein: FIG.", "1 depicts an illustrative embodiment of a broadcast paging system; FIG.", "2 depicts an illustrative embodiment of an LTE broadcast paging system; FIG.", "3 depicts an illustrative embodiment of a process used in portions of the system described in FIGS.", "1 and 2 ; FIG.", "4 depicts an illustrative embodiment of another process used in portions of the system described in FIGS.", "1 and 2 ; FIG.", "5 depicts an illustrative embodiment of a web portal for interacting with the communication systems of FIGS.", "1 and 2 ; FIG.", "6 depicts an illustrative embodiment of a communication device; and FIG.", "7 is a diagrammatic representation of a machine in the form of a computer system within which a set of instructions, when executed, may cause the machine to perform any one or more of the methods described herein.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "14/963,468, filed Dec. 9, 2015, which is incorporated by reference herein in its entirety.", "FIELD OF THE DISCLOSURE The subject disclosure relates to a method and system for selective paging of wireless devices using a cellular broadcast service.", "BACKGROUND A Long Term Evolution (LTE) capable, mobile communication device establishes connections and receives high-speed mobility services by a process that includes attachment to a Mobility Management Entity (MME) of an Evolved Packet Core (EPC) portion of a wireless mobility network.", "In a Connected state, the mobile device sends and/or receives data by way of a radio bearer established through a base station of the mobility network.", "While not engaged in an active exchange of data packets, the mobile device generally reverts to an idle state.", "Namely, the mobile device is released when an inactivity timer has been exceeded.", "For mobile devices in the idle state, a Serving Gateway (SGW) of the EPC terminates the downlink data path to the mobile device.", "The SGW also triggers a downlink data notification towards the MME that results in the MME paging of a given mobile device in response to a reception of downlink data directed to the idle mobile device.", "In traditional paging, the MME individually pages the idle mobile device to indicate a presence of pending downlink data traffic.", "The paging message triggers the mobile device to reply with a service request.", "Processing of the service request transitions the mobile device to a connected state, allowing the mobile device to receive the user data via a unicast packet flow.", "BRIEF DESCRIPTION OF THE DRAWINGS Reference will now be made to the accompanying drawings, which are not necessarily drawn to scale, and wherein: FIG.", "1 depicts an illustrative embodiment of a broadcast paging system; FIG.", "2 depicts an illustrative embodiment of an LTE broadcast paging system; FIG.", "3 depicts an illustrative embodiment of a process used in portions of the system described in FIGS.", "1 and 2; FIG.", "4 depicts an illustrative embodiment of another process used in portions of the system described in FIGS.", "1 and 2; FIG.", "5 depicts an illustrative embodiment of a web portal for interacting with the communication systems of FIGS.", "1 and 2; FIG.", "6 depicts an illustrative embodiment of a communication device; and FIG.", "7 is a diagrammatic representation of a machine in the form of a computer system within which a set of instructions, when executed, may cause the machine to perform any one or more of the methods described herein.", "DETAILED DESCRIPTION Traditional unicast paging methodology is not practical when downlink data is intended for large numbers of mobile devices in an idle mode.", "This is precisely the scenario envisioned for Machine-to-Machine (M2M) environments, such as the Internet of Things (IoT).", "Application of the unicast paging approach for such large numbers of devices would be expensive and result in an inefficient utilization of core network resources due to the paging of each device individually and associated signaling network management load.", "The signaling load becomes even greater when any of the paged devices are temporarily unavailable.", "In these circumstances, the paging cycle, which can take several seconds per device, is repeated independently for each unavailable device.", "The subject disclosure describes, among other things, illustrative embodiments for a selective paging broadcast that utilizes a broadcast core network, e.g., a Multimedia Broadcast/Multicast Service (MBMS) network, or an evolved MBMS (eMBMS) network for LTE applications, as an intelligent and efficient means of delivering paging by providing data to large volumes and groups of wireless communication devices, including devices in an idle state or mode configuration.", "Other embodiments are described in the subject disclosure.", "One or more aspects of the subject disclosure include a process that includes detecting a data transfer request to wirelessly transfer data to a class of wireless communication devices.", "A geographical region associated with the data transfer request is determined.", "Responsive to the data transfer request and based on the geographical region, a number of wireless base stations of a wireless mobility network are identified that provide wireless communication services within the geographical region, comprising a Multimedia Broadcast Multicast Service (MBMS) service.", "A wireless transmission is facilitated of a broadcast message by the plurality of wireless base stations, wherein the broadcast message identifies the class of wireless communication devices.", "The broadcast message initiates a state transition to an active state for wireless communication devices of the class of wireless communication devices configured in an idle state at a time of the wireless transmission of the broadcast message.", "One or more aspects of the subject disclosure includes a device including a processor and a memory that stores executable instructions that, when executed by the processor, facilitate performance of operations.", "The operations include identifying a request to transfer pending data to a class of wireless communication devices within a geographical region.", "The operations further include identifying a number of wireless base stations of a wireless mobility network, responsive to the request, wherein the plurality of wireless base stations provide wireless communication services comprising a Multimedia Broadcast Multicast Service (MBMS) service within the geographical region.", "A wireless transmission is facilitated of a first broadcast message by the number of wireless base stations, wherein the first broadcast message identifies the class of wireless communication devices.", "The first broadcast message initiates a state transition to an active state for a plurality of wireless communication devices of the class of wireless communication devices configured in an idle state.", "One or more aspects of the subject disclosure include a machine-readable storage medium, that includes executable instructions that, when executed by a processor, facilitate performance of operations.", "The operations include determining a request to transfer data to a group of wireless communication devices within an area.", "Wireless base stations of a wireless mobility network are identified, responsive to the request, wherein the wireless base stations provide wireless communication services within the area, including a Multimedia Broadcast Multicast Service (MBMS) service.", "A wireless transmission is facilitated of a first broadcast message by the wireless base stations, wherein the first broadcast message identifies the group of wireless communication devices.", "The first broadcast message initiates a state transition to an active state for a plurality of wireless communication devices of the group of wireless communication devices configured in an idle state.", "FIG.", "1 depicts an illustrative embodiment of a broadcast paging system 100 that includes a wireless mobility network 102 providing wireless services to wireless communication devices 110 within a wireless coverage region.", "In some embodiments, the wireless mobility network 102 includes a group communications service network architecture.", "The group communications service architecture provides a one-to-many communications capability that supports a sharing of resources, including a sharing of radio resources, such as radio spectrum.", "In some embodiments, the wireless mobility network 102 can transmit data wirelessly over a multicast-broadcast single frequency network.", "Multimedia broadcasting, such as network television, cable programs, and/or sporting events, can be broadcast over the mobile communication system 102 using broadcasting and/or multicasting.", "Application service providers, such as equipment manufacturers, suppliers, maintainers, operators, and the like, can broadcast data, including instructions, software, software updates, features, configuration changes, and the like, over the wireless mobility network 102 using broadcasting and/or multicasting.", "The use of broadcasting and/or multicasting can provide the bandwidth and system efficiencies that are achieved by broadcasting via other channels, such as cable, satellite, and (to a lesser extent) the Internet.", "MBMS technology can provide live content, as well as popular file download delivery, to users of mobile communication devices 110 over the wireless mobility network 102.In more detail, the example wireless mobility network 102 can be based at least in part on standards developed by the 3rd Generation Partnership Project (3GPP) initiative, with information available at www.3gpp.org.", "By way of non-limiting example, some 3GPP standards that address group communications system architecture using LTE broadcast (LTE-B) include: 3GPP TS 23.468, entitled “Group Communication System Enablers for LTE (GCSE_LTE)”; 3GPP TS 25.324, entitled “Broadcast/Multicast Control BMC”; 3GPP TS 23.041, entitled “Technical Realization of Cell Broadcast Service (CBS)” and 3GPP TS 22.246, entitled “MBMS User Services,” all incorporated herein by reference in their entireties.", "In one embodiment, the wireless mobility network 102 includes a radio access network portion 105 and a core network portion 104, e.g., an Enhanced Packet Core (EPC) or common back bone that can communicate with one or more external networks, sometimes referred to as packet data networks or peer entities.", "It is envisioned, that the wireless mobility network 102 can include, without limitation, other configurations, such as those associated with General Packet Radio Service (GPRS), generally understood to serve the 2G and/or 3G cellular system.", "The radio access network portion 105, without limitation, can include an LTE network architecture sometimes referred to as Evolved Universal mobile Telecommunication system Terrestrial Radio Access (E UTRA) and evolved UMTS Terrestrial Radio Access Network (E-UTRAN).", "Broadly, the radio access network portion 105 can include one or more wireless mobile terminals or communication devices, sometimes referred to as user equipment (UE), and one or more wireless access nodes, or base transceiver stations.", "The base station 106, such as an evolved Node B (e-NodeB) in EUTRAN, communicates with the UE 110 over the air and wirelessly.", "The UEs 110 can include, without limitation, any device including a wireless communication capability, sometimes referred to generally as wireless devices, e.g., satellite communication systems, portable digital assistants (PDAs), laptop computers, tablet devices, other mobile devices.", "More generally, the wireless devices include any wireless network accessible device (e.g., cellular telephones, machines or “things,” such as smart appliances, and so on).", "Although reference is made to user equipment, it is generally understood that the UE 110 can include network accessible devices that can operate without user intervention or control, e.g., as in Machine-to-Machine (M2M) scenarios, such as the Internet of Things (IoT).", "Such UEs 110 can connect to the eNBs 110 when the UE 110 is within range according to a corresponding wireless communication technology.", "In some embodiments, the UE 110 executes application specific instructions that may or may not execute in association with an operating system.", "The instructions can include an operating system that can include one or more applications that engage in a transfer of data between the UE 110 and one or more of the external networks 121.Such data transfers can include downlink packet transfers from the external network 121 to the UE 110, uplink packet transfers from the UE 110 to the external network 121 or combinations of uplink and downlink packet transfers.", "Applications can include, without limitation, web browsing, VoIP, streaming media, file transfers, software updates, security, operation and/or control, application specific programs, and the like.", "In some embodiments, the data transfer includes streaming media, including one or more of audio, video, audio and video, text, still images, graphics, commands, video gaming content, and the like.", "Each data transfer can have an associated Quality of Service (QoS), such as a QoS imposed by an associated application.", "Different packet transfers can be served by different bearers within the core network 104, e.g., according to parameters, such as the QoS.", "The core network 104 can use a concept of bearers, e.g., enhanced packet service (EPS) bearers, to route packets, e.g., IP traffic, between a particular gateway in the core network 104 and the UE 110.A bearer refers generally to an IP packet flow with a defined QoS between the particular gateway and the UE 110.The access network 102, e.g., E-UTRAN, and the core network 104 together set up and release bearers as required by the various applications.", "The core network 104 includes various network entities, such as a Mobility Management Entity (MME) 126, a Serving Gateway (SGW) 130 and a PDN gateway (PGW) 132.In some embodiments, the MME 126 includes a control node that performs a control signaling between various equipment and devices in the radio access network 105 and the core network 104.In one or more embodiments, the mobility network 104 can include one or more broadcast multicast service centers (BMSC) 122, or content servers 122, and one or more MBMS Gateway (MBMS-GW) devices 124, or broadcast media gateways 124.The content servers 122 can be capable of selecting, access, and/or receiving data, including messages, software, updates, and the like.", "The content servers 190 can receive data from data networks, content source providers (e.g., equipment manufacturers, operators, maintainers, television networks or production companies, or sporting leagues), satellite feeds, and/or cable networks.", "The mobility network 104 can direct a content server 190 to select a particular data item or set of data items for broadcast to user devices 110 via the mobility network 104 and radio access network 105.In one or more embodiments, the mobility network 104 can include one or more MBMS-GWs 124.Each broadcast/multicast media gateway 124 manages data paths for transfer of data, including transmission of media, from a content server, referred to generally as a Content Data Network (CDN) 134 to one or more end user devices 110.In one embodiment, a MBMS-GW 124 can initiate multicast groups, which can allow end user devices 110 to receive multicast content at eNodeB nodes 106.The MBMS-GW 124 can associate each multicast group under its control with unique Internet Protocol (IP) addresses and can offer access to broadcast content that is associated with the multicast group to the end user devices 110 via one or more eNodeB nodes 106.In one embodiment, end user devices 110 can join an offered multicast group by sending a session initiation protocol (SIP) JOIN message to the offering MBMS-GW 124.In one or more embodiments, the MBMS-GW 124 can manage the initiation and maintenance of bearer paths for transmitting broadcast data to the user devices 110.In one or more embodiments, the MBMS-GW 124 can initiate MBMS sessions with bearer path contexts that are associated with each end user device 100 that has joined each multicast group.", "The bearer path allows the end user device 110 to receive multicast and/or broadcast data from the MBMS network 130.The MBMS-GW 124 can store MBMS session attributes for each bearer context.", "When a bearer path has been initiated, the MBMS-GW 124 can initiate tunnels for user data traffic to particular eNodeB nodes 106 that service end user devices 110 in a particular serving area.", "In one or more embodiments, the CDN 134 can transmit media content to BMSC that could send the data to one or more MBMS-GW 124 as a unicast data transfer, including a message, a data file, an image, audio, and/or a media stream.", "In one example, the content server 134 can transmit a direct, unicast stream and/or broadcast message and/or data item to each MBMS-GW 124.In one or more embodiments, the MBMS-GW 124 can generate a multicast and/or broadcast data stream from a received unicast data stream.", "The MBMS-GW 124 can transmit the multicast and/or broadcast data stream via the bearer path, and the multicast IP address for multicast applications.", "End user devices 110 that are members of the multicast group for the broadcast media can receive the multicast data transfer from the eNodeB 106 using the multicast IP address.", "In one or more embodiments, the mobility network 104 can include a pool of MBMS-GW devices 124 that are deployed in a distributed architecture (i.e., not centralized) in data centers spread across a geographic region that is served by an LTE broadcast service area.", "In one embodiment, an LTE broadcast service area can be coincident with a geographic region.", "A series of BMSC groups 122 can, for example, be spread across an LTE broadcast service area to provide multicast-broadcast content to user equipment devices 110 in the broadcast service area.", "For illustration purposes only, the MME 126, the SGW 124, the PGW 132, the BMSC 122 and the MBMS-GW 124 network elements or nodes, and so on, can be server devices, but may be referred to in the subject disclosure without the word “server.” It is also understood that any form of such servers can operate in a device, system, component, or other form of centralized or distributed hardware and software, including virtual machines, e.g., in relation to software defined networks.", "It is further noted that these terms and other terms such as bearer paths and/or interfaces are terms that can include features, methodologies, and/or fields that may be described in whole or in part by standards bodies such as the 3GPP and IETF.", "It is further noted that some or all embodiments of the subject disclosure may in whole or in part modify, supplement, or otherwise supersede final or proposed standards published and promulgated by 3GPP/IETF.", "The PGW 132 can provide connectivity between the UE 110 and one or more of the external networks, referred to generally as a content data network (CDN) 134.In the illustrative network architecture 100, the PGW 132 can be responsible for IP address allocation for the UE 110, as well as one or more of QoS enforcement and flow-based charging, e.g., according to rules from a policy and charging runes (PCRF) (not shown).", "The PGW 132 is also typically responsible for filtering downlink user IP packets into the different QoS-based bearers.", "In at least some embodiments, such filtering can be performed based on traffic flow templates.", "The PGW 132 can also perform QoS enforcement, e.g., for guaranteed bit rate bearers.", "The PGW 132 can also serves as a mobility anchor for interworking with non-3GPP technologies such as CDMA2000 and WiFi.", "With increasing numbers of users/devices receiving the same services, efficient information distribution is essential.", "To this end, group communications, such as broadcast and/or multicast techniques are provided to decrease the amount of data within the network 100 and a sharing of limited radio spectrum, resulting in a more efficient use of network resources.", "In particular, broadcast and multicast are techniques for transmitting data-grams from a single source, such as a selective paging application server 118, e.g., that facilitates a selective paging function, and or the CDN 134 to several destinations, e.g., point-to multipoint.", "The selective paging application server 118 and/or a group communication server of the CDN 134 can support exchanging signaling, e.g., signaling (including GCS session and group management aspects) with UEs 110, in some instances, receiving uplink data from UEs 110, delivering data to all UEs 110 belonging to a group, e.g., using unicast and or MBMS delivery, transporting application level session information, and supporting service continuity procedures, e.g., for a UE 110 to switch between unicast/MBMS delivery.", "Generally speaking, a multimedia broadcast/multicast service refers to a unidirectional point-to-multipoint service in which data is transmitted from a single source entity to a group of users in a specific area.", "In at least some embodiments, the MBMS services transmit content over a multicast-broadcast single frequency network.", "The broadcast/multicast service has two possible modes: Broadcast mode and Multicast mode.", "A broadcast session includes a continuous and time-bounded reception of a broadcast service by the UE 110.Likewise, a multicast session is a continuous and time-bounded reception of a multicast service by the UE 110.A broadcast service can be defined as a unidirectional, point-to-multipoint service in which data is efficiently transmitted from a single source to multiple UEs 110 in an associated broadcast service area.", "Broadcast services may be received by UE 110 configured to access broadcast service locally, and who are in the broadcast area defined for the service.", "Likewise, a multicast service can be defined as a unidirectional point-to-multipoint service in which data is efficiently transmitted from a single source to multiple UEs 110 in an associated multicast service area.", "It is generally understood that a multicast service is directed to a multicast subscription group.", "For example, UE access to a multicast service requires a subscription associates the UE 110 with the service.", "Broadcast and/or multicast services may be received by all UEs 110 configured to receive broadcast and/or multicast service(s), and fall within an associated broadcast/multicast area defined for the service.", "For example, the broadcast/multicast service area can be determined according to wireless coverage maps of base transceiver stations 106, e.g., sectors, regions and so on, that provide broadcast/multicast service.", "The UEs 110 can be configured to monitor one or more broadcast channels for such broadcast/multicast messages.", "The UEs 110 can be configured to monitor a selective paging channel, such as a broadcast channel, whether the UE 110 is in an idle state or an active state.", "The UE 110 does not need to be attached to any particular eNB 106 while monitoring the broadcast channel.", "The broadcast-multicast service area can represent a geographical area, such as a region, a state, county, town, an area defined by a geometric shape, such as a polygon, circle, ellipse, a piecewise continuous closed shape or some combination thereof in reference to a geographical region, e.g., as defined by a map.", "In some applications the broadcast area can be defined individually per broadcast service application, per broadcast service subscriber, and the like.", "For example, an emergency broadcast message can have a broadcast area associated with a content of the message, a subscription of the service.", "Consider an emergency broadcast message directed to an area affected by a natural event, such as a hurricane, a flash flood or a forest fire, an Amber Alert, and the like.", "In some embodiments, the group communication service area is identified by a requesting entity, such as a news station, a government entity, and so on.", "For group communications services, the example network architectures 100 include an interface 140 or reference point by which the MBMS services of the mobility network can be accessed.", "For example, in LTE applications, the selective paging application server 118 can be implemented by a Group Communication Service Application Server (GCS-AS), in which instances the interface or reference point 140 can include features of an MB2 interface.", "This represents one possible implementation option.", "The MB2 interface 140 can include a signaling or control plane interface, e.g., MB2-C, and a data or user plane interface, e.g., MB2-U.", "As illustrated, the MB2 interface 140 can exist between the BMSC 124 and the selective paging application server 118, or more generally between the BMSC 124 and a Group Communication Service Application Server (GCS-AS).", "It is understood that the particular network elements of the example network architecture 100 are representative.", "Although the MB2 reference point 140 is disclosed in certain industry standards, it is understood that any reference to MB2 herein can include features of applicable industry standards, with or without additions, deletions and modifications to any applicable standardized features.", "In at least some embodiments, the MB2 interface 140 or reference point provides an ability for applications to request an allocation and/or de-allocation of a set of TMGIs, a request to activate, deactivate and modify an MBMS bearer, and for allowing the BMSC 122 to notify an application of the status of an MBMS bearer.", "In at least some embodiments, the MB2 reference point 140 can include one or more other features disclosed herein, such as supporting a selection of a particular network element and/or network configuration in relation to an establishment and/or maintenance of any MBMS bearer services.", "In establishing a new group communication service, e.g., in response to a request from the selective paging application server 118, the BMSC 122 can initiate a group communication service session request directed to the MBMS-GW 124.The MBMS-GW 124 responds to the BMSC 122 with session response.", "The MBMS-GW 124 then sends a session start request to the MME 126, which sends it to the eNB 106, e.g., on an M3 Stream Control Transmission Protocol (SCTP) based interface.", "In response, the eNB 106 sends a session start response to the MME 126, which sends it to the MBMS-GW 124.Upon successful establishment of the session and radio resource allocation, the eNB 106 can join the transport network IP multicast address to receive the user data from MBMS-GW 124.An example broadcast and/or multicast bearer path 141 is illustrated between the selective paging application server 118 and the UE 110.Other network elements along the broadcast and/or multicast bearer path 141, include the BMSC 122, the MBMS-GW 124 and the eNB 106.In some embodiments, the broadcast and/or multicast path extends from another data source, such as the content data network 134.Thus, the selective paging application server 118 can request a broadcast and/or multicast service based on data item(s) from another source, such as the CDN 134.It is understood that, in some instances, broadcast and/or multicast datagrams can be routed to more than one UE 110 attached to the same eNB 106.Alternatively or in addition, broadcast and/or multicast datagrams can be routed to more than one UE 110 attached to different eNBs 106.Without limitation, reference to various interfaces, such as S1, S5, S11, M1, and M3 refer to EPS interfaces.", "In some instances, such interface designations are combined with a suffix, e.g., a “U” or a “C” to signify whether the interface relates to a “User plane” or a “Control plane.” In addition, the core network 104 can include various signaling bearer paths/interfaces, e.g., control plane paths/interfaces.", "The bearer paths and signaling bearer paths are only illustrated as examples and it should be noted that additional bearer paths and signaling bearer paths may exist that are not illustrated.", "FIG.", "2 depicts an illustrative example of an LTE broadcast paging system 200 that includes a RAN portion 205 and a core network portion 204.The RAN portion 205 includes three base station terminals 206a, 206b, 206c, generally 206.The first base station terminal 206a provides wireless services within a first wireless coverage region 208a, e.g., a location in California.", "Likewise, the second and third base station terminals 206b, 206c, provide wireless services within second and third wireless coverage regions 208b, 208c, e.g., non-overlapping regions in New York.", "In the illustrative example, the wireless communication devices include a vehicle 210, and or an equipment item or subsystem of the vehicle, such as an on-board computer, a vehicle maintenance tracking system, a vehicle emergency communication system, a surveillance system and/or a navigation system.", "Subsequent references to the vehicle 210 should be understood to include one or more of the aforementioned subsystems.", "During network operations, at least one base station 206 can generally communicate with the vehicle 210, while the vehicle is within a corresponding wireless coverage region of the base station 206.It is understood that there may be circumstances in which the vehicle 210, despite being within the coverage region, is unable to communicate with the base station 206.By way of non-limiting example, such circumstances include radio frequency (RF) interference, RF blockage or weak signal, power on/off status of the vehicle 210/on-board device or system, and so on.", "For example, in the illustrative example, a first facility 211a, such as an office building, or apartment complex includes an underground parking facility 212a.", "Likewise, second and third facilities 211b, 211c include underground parking facilities 212b, 212c.", "Each of the facilities 211a, 211b, 211c, generally 211, includes a vehicle 210a′, 210b′, 210c′, generally 210′, within the underground parking facility 212a, 212b, 212c, generally 212.Each of the facilities 211 also reflects the same vehicle 210a″, 211b″, 210c″, generally 210″, e.g., at a different time, along an above-ground surface 214.It is understood that the vehicles 210′ may not be able to communicate with the base stations 206 while inside the garage 212 due to RF blockage.", "It is also understood that the vehicles 210″ would generally be available to communicate with the base stations, while not inside the garage 212, presuming the vehicles 210″ are within the wireless range of a broadcasting base station 206.Thus, any attempts by the network 204 and base stations 206 to page vehicles 210′ while inside the garage 212 will likely be unsuccessful due to the RF blockage.", "In some embodiments, a paging message can be repeated according to a schedule.", "The schedule can include one or more of a total number of pages, a paging duration including a time period within which a paging message is repeated, a paging frequency, paging times, and so on.", "Repeating the same page to the same group of vehicles 210 within the same targeted paging area 208, over an extended time period allows for vehicles 210′ that may have been unavailable for an initial page, e.g., in the garage, to receive a subsequent page that occurs during the paging period, while the vehicle 210″ is out of the garage.", "In an illustrative example, each of the vehicles 210 listens to a broadcast channel of the mobility network 200, whether the vehicle 210 is in idle mode or an active mode, including unconnected and connected modes.", "A data transfer entity, such as an equipment manufacturer, a supplier, a maintainer, an insurer of the vehicle 210, or onboard system, intends to perform certain actions to a class or group of vehicles, and/or onboard systems, within a target geographical region, e.g., New York, by way of the mobility network 200.A selective paging broadcast function, e.g., by way of a selective paging broadcast server 218, queries or otherwise accesses a cell-site records, e.g., by way of a RAN cell-site database 220, to identify any cell sites providing wireless services within the target geographical region.", "The selective paging broadcast server 218 creates a short broadcast message including indicia of the targeted class or group of vehicles 210 and/or vehicular subsystems.", "The indicia can include a manufacturer, make, model, serial number range, lot number, product identification code, vehicular identification code, a signature, an owner (e.g., a fleet owner or operator), a user, an operator, and the like.", "The selective paging broadcast server 218 sends the short broadcast message to the core network 204 for forwarding to the identified cell sites of the target geographical area.", "In the illustrative example, the message is sent to the cell sites 208b, 208c in New York, without being sent to other cell sites, such as cell sites 208a in other states, e.g., California.", "The core network 204, in turn, initiates a broadcast of the short broadcast message through the identified base stations 208b, 208c of the target geographical area, without sending the short message, or otherwise initiating a broadcast through cell sites 208a outside of the target region.", "The vehicles 210 in the coverage area, whether in idle or connected mode, listen to a broadcast channel of the mobility network 202.Any broadcast messages are evaluated by the vehicles 210 to identify the class/group indicator, e.g., a unique value, symbol, code or signature.", "Broadcast messages having a unique value that is not associated with the vehicle 210 are ignored by the vehicle 210 or subsystem.", "Broadcast messages having a unique value that is associated with the vehicle 210 are processed further, e.g., as indicated below.", "Any vehicles 210′ in the coverage area, but unable to receive a particular broadcast message, e.g., due to blockage, continue to monitor the broadcast and/or paging channel When any such blockage or interference is removed, e.g., when the vehicle 210″ emerges from the garage 212, the continuous monitoring of the broadcast and/or paging channel allows the vehicle 210″ to receive a subsequent page of a repeating paging schedule.", "Once the short broadcast message is received and the unique value or signature matched to the vehicle 210″, the vehicle 210″ recognizes the broadcast feed and performs a related action.", "Actions can include, without limitation, interpreting data contained in the broadcast message itself.", "For example, in some embodiments, the short broadcast message can include a payload portion.", "The payload portion can include data, such as value or code providing an instruction that can be interpreted by the targeted vehicle 210″.", "For example, the targeted vehicle 210″ can include pre-programmed instructions that enact one or more predetermined procedures based on the data value.", "In some instances, the instruction can provide an indication that further data is available by way of another message.", "The other message can include download data packets, such as a packet stream, that is broadcast to the target devices, e.g., through the identified base stations 206, by way of a separate MBMS service.", "Thus, a broadcast paging message provided on one broadcast/paging channel, can announce services on the same and/or a different broadcast channel The different broadcast channel can be distinguished by one or more of a time slot, frequency, and code of a code division multiplexed configuration, and the like.", "The MBMS service can include a broadcast service, by which data content is distributed according to a broadcast.", "A broadcast service, e.g., announced by the short broadcast message, can be accessed by the targeted vehicles 210″ that receive the message.", "Namely, the targeted vehicles 210″ can tune or otherwise access the broadcast stream.", "Alternatively or in addition, the MBMS service can include a multicast service, by which data content is distributed according to a multicast stream.", "A multicast service, e.g., announced by the short broadcast message, can be accessed by the targeted vehicles 210″ that receive the message.", "For example, the targeted vehicles 210″ can join or otherwise access the multicast stream.", "In at least some embodiments, the short broadcast message can include a multicast IP address that can be used by the targeted vehicles 210″ to join the multicast stream being served by the base stations that have joined the specific MBMS GW nodes.", "Although the examples provide herein refer to vehicles and/or on-board devices or systems as the wireless communication devices, the disclosure should be understood to apply to wireless communication devices more generally.", "This can include wireless mobile devices, such as vehicles, smart phones, tablet processors and laptop computers.", "Other wireless communication devices are not mobile, such as smart meters, e.g., home/building utility meters—gas, water, electricity and so on.", "Wireless devices can include medical devices, such as biomedical devices including, without limitation, implantable devices, wearable devices, hospital and/or home medical monitoring devices, the like.", "Medical devices can include diagnostic devices, e.g., heart monitors, blood glucose monitors, drug delivery devices, biological pumps, controllers and so on.", "As for vehicular devices, they can include the vehicles, e.g., automobiles, themselves, equipment in the vehicle, e.g., updated map software for a navigation system, diagnostic monitoring systems, e.g., mileage, fluids, tire pressures, engine performance, etc.", "Vehicles can include, without limitation, trucks, busses, trains fleets of vehicles, e.g., trucking company, self-driving vehicles, equipment on such vehicles.", "Air vehicles can include, without limitation, aircraft, drones, military equipment and ordnance.", "Other applications include manufacturing, e.g., robots, machines, processors, and the like.", "Still other applications include business applications, such as retail outlets, e.g., gas stations tracking supplies/sales, supermarkets, wholesale facilities, e.g., tracking warehouse inventories, shelf lives, etc.", "Durable goods, e.g., home appliances and the like.", "In general, wireless communication devices can include any device, mobile or stationary, that can communicate with the wireless mobility network via the radio access network.", "The short broadcast messages can be used by data transfer entities in the tracking of performance and/or status, in updating software, e.g., in providing software patches, fixes, updates, and the like.", "In at least some embodiments, the short broadcast messages can be used by the data transfer entities to deliver, revise or otherwise modify operational or business rules of the wireless communication device, or another device in communication therewith.", "To that end, it is envisioned that the wireless communication devices can be part of other systems, such as the vehicles, the processors, devices, and appliances.", "Namely, a wireless communication device, e.g., operating according to a wireless protocol, such as LTE, can be in communication with an associated device.", "Thus, data can be exchanged between the associated device and a remote entity by way of the wireless communication device.", "In this capacity, data content received by way of the broadcast messages can be used by the wireless communication device, the associated device, or both.", "It should be understood that the group communication service messages, e.g., MBMS/eMBMS messages disclosed herein, can include a type of service (broadcast/multicast), an associated radio frequency channel(s), timing/schedule, authorization/encryption/key info, multicast IP addresses, and the like.", "FIG.", "3 depicts an illustrative embodiment of a process 300 used by the systems 100, 200 of FIGS.", "1 and 2.The process includes detecting a broadcast data request to access target class/group of wireless devices at 302.The request can include a message received from another entity, such as the data transfer entities 216a, 216b, 216c, generally 216, indicating that download data is available for the target class/group of wireless communication devices.", "These entities can include, without limitation, equipment manufacturers, service providers, e.g., network service providers, owners, operators, maintainers, business organizations, enterprises, governmental organizations, educational institutions, and the like.", "In at least some embodiments, the broadcast data request includes a field that identifies the target class/group.", "For example, a request from an auto manufacturer BMW® to access an onboard system of the “Series 3” automobiles.", "It is envisioned identification of such a target class/group can include further details, such as year or range of years, model options/features, and the like.", "In some instances, a field identifying the target class/group includes a unique value, such as an alphanumeric value or signature.", "Such signature values would allow a rather complex description of a particular device, i.e., “BMW, 320i, 2015, sedan, manual transmission, .", ".", ".", "” can be reduced to a shorter numeric value, e.g., “BM32SM15.” In some instances the unique signature values can include a product code, such as a vehicle identification number, or range of numbers.", "In some embodiments, hashes and/or other algorithms can be used to generate and/or interpret such identifying codes.", "Translations can be performed by the data transfer entities 216, by the selective paging broadcast server 218, or by another server, such as the server 240.For example, the other server 240 can be operated by a third party, any of the data transfer entities, or the network service provider.", "However the target class/group is identified in the message, the mobile communication devices 210 include features, e.g., machine-readable instructions 144, that allow the device 210 to properly identify when a paging broadcast message is directed to it as a member of the targeted class/group.", "In some embodiment, the request message also includes a geographic region.", "The geographic region, e.g., can be used by a data transfer entity to download data in an orderly manner.", "Alternatively or in addition, another entity, such as the network operator, can specify the target region.", "Consider an auto manufacturer that needs to roll out new software to all diesel vehicles in North America.", "The manufacturer, as a data transfer entity can identify North America as a target region in its request—it is understood that in some instances, a request may not include a region, in which case the region can include all cell sites of one mobility network, cell sites of another mobility network, another country, region, etc.", "In some embodiments, a network service provider can apply analytics to the request to determine a strategic rollout of the software in a staged manner that takes into consideration any of various factors, such as network capacity, network congestion, network costs, estimates of numbers of wireless communication devices, and the like.", "Thus, a request made during a busy hour can be deferred to quieter times, such as early morning, weekend, etc.", "A target geographical region is determined at 304.In some embodiments, the target geographical region can be determined directly from the request, e.g., “New York.” Alternatively or in addition the target geographical region can be determined from a processing of the request in view of network analytics, among other factors.", "Thus, a large area, such as North America, can be broken into regions, such as states, territories, counties, bounded regions of a map, and combinations thereof.", "Wireless base stations are identified at 306 based on target region.", "Once the target geographical region has been identified, it can be used in combination with cellular coverage maps to identify one or more base stations that provide coverage to the target geographical region.", "In some embodiments, the base stations provide full coverage spanning the entire target geographical region.", "Alternative, the base stations may provide a partial coverage, as coverage may not be available in certain portions of the geographical region.", "Nevertheless, a suitable number of base stations are identified based on the target geographical region.", "A target class/group is identified at 308.As indicated above, the target class/group can be determined from the request itself.", "It is understood, however, that in at least some instances, the request may generate from a reception of downlink data at a network node, such as the SGW 130.The downlink data can include an address, e.g., and IP address, that can be mapped or otherwise associated with the target class/group of devices.", "In such scenarios, the network service provider can seek an identity of the target class/group.", "This can be accomplished by storing or otherwise accessing an association of a data IP address and a corresponding class/group of devices.", "In some instances, the network service provider can query the data transfer entity associated with the data and or a third party, such as the server 140 providing a coordinating service.", "Broadcast paging to the target class/group in the target region is facilitated at 310 by way of the identified wireless base stations.", "For example, the selective paging application server 118, e.g., facilitating a selective paging function, forwards a request to the BMSC 122 to broadcast a broadcast message in each of the identified base stations.", "The broadcast message can include indicia of the target class/group of devices, as well as one or more of a message that invokes a corresponding action at wireless communication devices of the targeted class/group.", "For example, the message can inform the wireless device that a broadcast message will commence at a particular time, e.g., and on a particular broadcast channel.", "This can include identification of one or more of a frequency and a time slot.", "In some embodiments, the request prompts a selection between a broadcast, a multicast and/or a unicast service for paging the target class/group of devices.", "For example, such a selection can be based on set of attributes.", "In some instances, a mobile operator decides which service based on one or more of the identified base station(s), the identity of the target class/group, the target region, and so forth.", "Network analytics can be applied in a determination, e.g., based on a number of wireless devices per base station and/or sector coverage area, the type and/or quantity of data to be transferred, a priority, network charges, subscriptions, and the like.", "An estimate of a number of wireless devices can be based on one or more of device/product registration data, historical communication records, population, number of households, income and/or other demographics, or any other means of estimating.", "For example, historical records can be created and/or updated by devices periodically connect to network to complete status reporting and/or scheduled/on-demand data transfers based on combination of triggers received from device/network and application service providers.", "It is also envisioned that learning can be applied based on a network analytics function that includes cell site data, targeted coverage area, device type, priority access, etc.", "In at least some embodiments, a response to a selective broadcast page, e.g., including a transfer data (e.g., message and/or content) to UE, is accomplished for UE that are not in the connected state on the MME 126.A transfer of data, e.g., data arriving at the SGW 130, can be facilitated to the UE 110, including UE 110 in an idle state or mode, without requiring the UE 110 to initiate a service request and/or otherwise attach to the mobility network 104.In at least some applications data transfer to a group of UE 110 is initiated for UE 110 in an idle state or mode, without reliance on traditional, e.g., unicast paging.", "In at least some embodiments, any target devices 110 temporarily out of coverage during a selective paging broadcast message, receive the broadcast message upon returning into coverage of selected eNBs.", "There is no need for UE to provide location information in association with accessing broadcast content disclosed herein.", "Likewise, there is no need for a notification server to repeatedly invoke unicast updates when devices are temporarily unreachable.", "In at least some applications, particularly for M2M and IoT applications, the paging and any subsequent actions undertaken by the wireless device and/or the network can occur without requiring the devices to respond to paging.", "This avoids any necessity for the devices to attach to the network, etc., to avoid corresponding network congestion that might otherwise be created.", "In general, an idle mode is considered to include a wireless device (UE) that is powered on but does not have a Radio Resource Control (RRC) connection to the radio network.", "In the idle mode, a UE can perform: PLMN selection; cell search & selection; cell reselection; Tracking Area (TA) update; and periodic paging monitoring.", "In response to monitoring a page that identifies the device, the device can transition to an active mode, in which the device may change one or more of a power status, processing capacity, and the like, without necessarily attaching to the wireless mobility network.", "For example, in the active mode, the device can receive a broadcast message at a predetermined time and channel, without requiring any special action on the part of the mobility network.", "In some embodiments, the wireless device transitions to an active mode upon receipt of the page message.", "The transition can be immediate, or after some processing delay, e.g., time to allow the device to detect the page message and to determine that the device has been targeted.", "A transition from idle to active states can be referred to generally as a service request.", "It is conceivable that in some applications, a large number of targeted devices residing within a single cell or region may receive and respond to the same page message.", "In at least some instances, concurrent service requests from multiple targeted devices can result in network traffic and possibly interference.", "In at least some embodiments, a delay can be introduced, to avoid network congestion of multiple service requests from the multiple devices.", "For example, each of the wireless devices can have an associated delay value.", "A unique delay value can be provided for every device, e.g., stored within the device, such that a number of devices that receive the same page message will transition to active mode, or submit a service request, at a uniquely different time based the unique delay values.", "Alternatively, a set of delay values can be assigned to the devices, such that not every device, but groups of devices have different delay values.", "It is understood that in at least some embodiments, a delay value can be determined by the wireless devices.", "For example, each wireless device can include functionality that determines a device delay value that can be implemented for every page message targeting the device.", "Alternatively or in addition, each wireless device can include functionality that determines an updated, different delay value for each page message.", "Delay values can be determined according to an algorithm and/or based on a random number generator.", "In some embodiments, the page message can include information that can be used to determine delay values, e.g., providing a seed value that can be used by a delay determining algorithm of the wireless device.", "Beneficially, the broadcast paging and data transfer techniques disclosed herein avoid any need for a notification server to repeatedly invoke unicast updates when devices are temporarily unreachable.", "As indicated, the MBMS messages can be repeated according to a schedule and for a duration.", "The duration might extend for hours, days, weeks, months or longer.", "The schedule might include the broadcast to be provided once per day or longer, e.g., at the same hour each day, or at a different hour each day.", "Beneficially, there is no need for the wireless communication devices to provide location information to the system.", "They just have to be in a target geographical area and in a sector served by a base station of the mobility network during an occasion of the MBMS/eMBMS message.", "This allows targeted devices to receive data downloads, instructions, etc., without a need to independently page the wireless communication devices.", "In some embodiments, the wireless communication devices can be configured to always listen to a network broadcast channel in idle and connected modes.", "To this end, a device that happens to be in a connected mode will still receive the MBMS/eMBMS service message.", "The network can be presented with an option to transfer data by way of an existing connection for any connected devices.", "Alternatively or in addition, the network can provide the corresponding data/instruction to all devices in the same manner, e.g., by broadcast message.", "FIG.", "4 depicts an illustrative embodiment of another process used by the systems 100, 200 of FIGS.", "1 and 2.A request to transfer data to target group of devices is received at step 402.Without limitation, the request can be received by the selective paging application server 118, e.g., from the data transfer entity 216 and/or by downlink data arriving at a node of the mobility network, such as the SGW 124, as disclosed herein.", "A determination is made at 406 as to whether the pending request is authorized.", "To the extent that the pending request is not authorized, it is terminated at 408.To the extent that the pending request is authorized, a geographical region associated with request is determined at 410.The region can be identified by the request itself, by the mobility network, by a third party service provider, or by any other suitable means of identifying a region that relates to the request.", "A determination is made at 412 as to whether the pending request is authorized for the associated geographical region.", "To the extent that the pending request is not authorized, it is terminated at 408.To the extent that the pending request is authorized, one or more wireless base station(s) are identified at 414, based on the target region.", "The identified base stations provide coverage within the target region.", "In some embodiments, the base stations provide coverage to the entire region, whereas in others such coverage is not possible.", "In the latter situation, the base stations are identified to provide the best coverage possible.", "The determination can be performed by the selective paging application server, by the network service provider, or by a third party service provider.", "In some embodiments a subsequent determination is made at 416 as to whether any paging will be accomplished by an MBMS service and/or a Unicast service at 416.It is understood that the MBMS/unicast determination can be determined globally for all identified base stations, or individually for each of the identified base station or sub-groups of base stations.", "To the extent that MBMS service is selected, an MBMS paging message is generated at 418, identifying the target group 418.An MBMS service is initiated at 420 and the paging message is distributed by way of the MBMS service.", "To the extent that additional data is associated with the paging message, an MBMS transfer of the pending data is initiated at 422.It is understood that an MBMS service for the paging service and the MBMS service for the subsequent data can be the same or different.", "For example, one can be provided by way of a broadcast message, whereas, the other can be accomplished by way of a multicast message.", "To the extent that unicast service is selected, one or more unicast paging messages are generated at 424, identifying members of the target group.", "A unicast service is initiated at 426 and the paging message is distributed by way of the unicast service.", "To the extent that additional data is associated with the paging message via MME 126, a unicast transfer of the pending data is initiated at 428.It is understood that the same unicast service or different unicast services can be used for each of the paging message and the subsequent data transfer.", "While for purposes of simplicity of explanation, the respective processes are shown and described as a series of blocks in FIGS.", "3 and 4, it is to be understood and appreciated that the claimed subject matter is not limited by the order of the blocks, as some blocks may occur in different orders and/or concurrently with other blocks from what is depicted and described herein.", "Moreover, not all illustrated blocks may be required to implement the methods described herein.", "The UE 110, 210, and selective paging application server 118, 218 can utilize tethered communication technologies (such as coaxial, powerline or phone line wiring) or can operate over a wireless access protocol such as Wireless Fidelity (WiFi), Bluetooth®, Zigbee®, or other present or next generation local or personal area wireless network technologies.", "By way of these interfaces, unicast communications can also be invoked between the core network 104, 204, or other infrastructure services.", "The subject disclosure can apply to other present or next generation over-the-air and/or in combination with landline media content services system.", "Some of the network elements of the system 100, 200 can be coupled to one or more computing devices 140, a portion of which can operate as a web server for providing web portal services over the wireless mobility network 100 to wireless communication devices 110.Multiple forms of media services can be offered to wireless communication devices 110, 210 by way of the wireless access base station 106, 206 operating according to common wireless access protocols such as Global System for Mobile or GSM, Code Division Multiple Access or CDMA, Time Division Multiple Access or TDMA, Universal Mobile Telecommunications or UMTS, World interoperability for Microwave or WiMAX, Software Defined Radio or SDR, Long Term Evolution or LTE, and so on.", "Other present and next generation wide area wireless access network technologies can be used in one or more embodiments of the subject disclosure.", "The cellular access base station 106, 206 can operate according to common wireless access protocols such as GSM, CDMA, TDMA, UMTS, WiMax, SDR, LTE, and so on.", "Other present and next generation wireless network technologies can be used by one or more embodiments of the subject disclosure.", "Accordingly, in at least some embodiments, multiple wireline and/or wireless communication technologies can be used by the UEs 110, 210.The server 140 can be operably coupled to the communication system 100, 200 for purposes similar to those described above.", "The server 140 can perform function 146 and thereby provide selective broadcast paging of wireless device services to the wireless communication devices 110.The wireless communication devices 110 can be adapted with software to perform function 144 to utilize the selective broadcast paging of wireless device services.", "The selective paging application server 118 can be adapted with software to perform function 142 to utilize the selective broadcast paging of wireless device services.", "For example, the selective paging application server 118 can receive one or more of an identification of a geographical area, a type or class of wireless communication device or other device or system associated with the wireless communication device, priorities of one or more of the device, the message, a class of service, and the like.", "A priority can be used, for example, to selectively page higher priority over lower priority, to set paging cycles, counts, frequency, etc.).", "Likewise, in at least some embodiments, one or more elements of the core network 104 can be adapted with software to perform functions 141 to utilize the selective broadcast paging of wireless device services.", "FIG.", "5 depicts an illustrative embodiment of a web portal 502 of a communication of the communication systems 100, 200 of FIGS.", "1 and/or 2.The web portal 502 can be used for managing services of systems 100, 200 of FIGS.", "1 and/or 2.In at least some embodiments, the web portal 502 can be used for managing services of the wireless communication devices 110, 210 of systems 100, 200 of FIGS.", "1 and/or 2.A web page of the web portal 502 can be accessed by a Uniform Resource Locator (URL) with an Internet browser using an Internet-capable communication device such as those described in FIGS.", "1 and/or 2.The web portal 502 can be configured, for example, to access a media processor selective paging application server 118 and services managed thereby such as a content delivery services, e.g., including software updates, data transfers, media access, and the like.", "The web portal 502 can also be used for provisioning M2M services, provisioning Internet services, provisioning wireless services, and so on.", "The web portal 502 can further be utilized to manage and provision software applications 242-246 to adapt these applications as may be desired by subscribers and/or service providers of the systems 100, 200 of FIGS.", "1 and/or 2.For instance, users of the services provided by the selective paging application server 118, 218 and/or server 140, 240 can log into their on-line accounts and provision one or more of the servers 118, 218, 140, 230 with a feature that a user may want to program such.", "For example, data transfer entities, such as device manufacturers, maintainers, and the like can use the web portal 502 to enter or otherwise modify requests for selective IoT paging broadcasts.", "Information can be entered in various manners, such as providing inputs to fields of a form, such as requestor identity or account, authorization information, indicia of a group or class of devices targeted by the broadcast paging message, a target area, such as a geographical region, data content and/or pointers or references to data content to be provided to the UEs 110, 210.At least some of the information can be provided by user profiles that can be created, reviewed, modified, and so on by the web portal 502.Alternatively or in addition, service providers can use the web portal 502 to log onto an administrator account to provision, monitor and/or maintain the systems 100, 200 of FIGS.", "1 and/or 2.FIG.", "6 depicts an illustrative embodiment of a communication device 600.Communication device 600 can serve in whole or in part as an illustrative embodiment of the devices depicted in FIGS.", "1 and/or 2 and can be configured to perform portions of processes 300, 400 of FIGS.", "3 and/or 4.The communication device 600 can include a wireline and/or wireless transceiver 602 (herein transceiver 602), a user interface (UI) 604, a power supply 614, a location receiver 616, a motion sensor 618, an orientation sensor 620, and a controller 606 for managing operations thereof.", "The transceiver 602 can support short-range or long-range wireless access technologies such as Bluetooth®, ZigBee®, WiFi, DECT, or cellular communication technologies, just to mention a few (Bluetooth® and ZigBee® are trademarks registered by the Bluetooth® Special Interest Group and the ZigBee® Alliance, respectively).", "Cellular technologies can include, for example, CDMA-1X, UMTS/HSDPA, GSM/GPRS, TDMA/EDGE, EV/DO, WiMAX, SDR, LTE, as well as other next generation wireless communication technologies as they arise.", "The transceiver 602 can also be adapted to support circuit-switched wireline access technologies (such as PSTN), packet-switched wireline access technologies (such as TCP/IP, VoIP, etc.", "), and combinations thereof.", "The UI 604 can include a depressible or touch-sensitive keypad 608 with a navigation mechanism such as a roller ball, a joystick, a mouse, or a navigation disk for manipulating operations of the communication device 600.The keypad 608 can be an integral part of a housing assembly of the communication device 600 or an independent device operably coupled thereto by a tethered wireline interface (such as a USB cable) or a wireless interface supporting for example Bluetooth®.", "The keypad 608 can represent a numeric keypad commonly used by phones, and/or a QWERTY keypad with alphanumeric keys.", "The UI 604 can further include a display 610 such as monochrome or color LCD (Liquid Crystal Display), OLED (Organic Light Emitting Diode) or other suitable display technology for conveying images to an end user of the communication device 600.In an embodiment where the display 610 is touch-sensitive, a portion or all of the keypad 608 can be presented by way of the display 610 with navigation features.", "The display 610 can use touch screen technology to also serve as a user interface for detecting user input.", "As a touch screen display, the communication device 600 can be adapted to present a user interface with graphical user interface (GUI) elements that can be selected by a user with a touch of a finger.", "The touch screen display 610 can be equipped with capacitive, resistive or other forms of sensing technology to detect how much surface area of a user's finger has been placed on a portion of the touch screen display.", "This sensing information can be used to control the manipulation of the GUI elements or other functions of the user interface.", "The display 610 can be an integral part of the housing assembly of the communication device 700 or an independent device communicatively coupled thereto by a tethered wireline interface (such as a cable) or a wireless interface.", "The UI 604 can also include an audio system 612 that utilizes audio technology for conveying low volume audio (such as audio heard in proximity of a human ear) and high volume audio (such as speakerphone for hands free operation).", "The audio system 612 can further include a microphone for receiving audible signals of an end user.", "The audio system 612 can also be used for voice recognition applications.", "The UI 604 can further include an image sensor 613 such as a charged coupled device (CCD) camera for capturing still or moving images.", "The power supply 614 can utilize common power management technologies such as replaceable and rechargeable batteries, supply regulation technologies, and/or charging system technologies for supplying energy to the components of the communication device 600 to facilitate long-range or short-range portable applications.", "Alternatively, or in combination, the charging system can utilize external power sources such as DC power supplied over a physical interface such as a USB port or other suitable tethering technologies.", "The location receiver 616 can utilize location technology such as a global positioning system (GPS) receiver capable of assisted GPS for identifying a location of the communication device 600 based on signals generated by a constellation of GPS satellites, which can be used for facilitating location services such as navigation.", "The motion sensor 618 can utilize motion sensing technology such as an accelerometer, a gyroscope, or other suitable motion sensing technology to detect motion of the communication device 600 in three-dimensional space.", "The orientation sensor 620 can utilize orientation sensing technology such as a magnetometer to detect the orientation of the communication device 600 (north, south, west, and east, as well as combined orientations in degrees, minutes, or other suitable orientation metrics).", "The communication device 600 can use the transceiver 602 to also determine a proximity to a cellular, WiFi, Bluetooth®, or other wireless access points by sensing techniques such as utilizing a received signal strength indicator (RSSI) and/or signal time of arrival (TOA) or time of flight (TOF) measurements.", "The controller 606 can utilize computing technologies such as a microprocessor, a digital signal processor (DSP), programmable gate arrays, application specific integrated circuits, and/or a video processor with associated storage memory such as Flash, ROM, RAM, SRAM, DRAM or other storage technologies for executing computer instructions, controlling, and processing data supplied by the aforementioned components of the communication device 600.Other components not shown in FIG.", "6 can be used in one or more embodiments of the subject disclosure.", "For instance, the communication device 600 can include a reset button (not shown).", "The reset button can be used to reset the controller 606 of the communication device 600.In yet another embodiment, the communication device 600 can also include a factory default setting button positioned, for example, below a small hole in a housing assembly of the communication device 600 to force the communication device 600 to re-establish factory settings.", "In this embodiment, a user can use a protruding object such as a pen or paper clip tip to reach into the hole and depress the default setting button.", "The communication device 600 can also include a slot for adding or removing an identity module such as a Subscriber Identity Module (SIM) card.", "SIM cards can be used for identifying subscriber services, executing programs, storing subscriber data, and so forth.", "The communication device 600 as described herein can operate with more or less of the circuit components shown in FIG.", "6.These variant embodiments can be used in one or more embodiments of the subject disclosure.", "The communication device 600 can be adapted to perform the functions of devices 110, 210 of FIGS.", "1 and/or 2.It will be appreciated that the communication device 600 can also represent other devices that can operate in systems 100, 200 of FIGS.", "1 and/or 2, such as a gaming console and a media player.", "In addition, the controller 606 can be adapted in various embodiments to perform one or more of the functions 242-246, respectively.", "Upon reviewing the aforementioned embodiments, it would be evident to an artisan with ordinary skill in the art that said embodiments can be modified, reduced, or enhanced without departing from the scope of the claims described below.", "For example, the data transfer entity can be a wireless mobile device, wherein the downlink data and/or a related request can be transported over wireless mobility network to the selective paging application server 118 and/or the other server 140.Other embodiments can be used in the subject disclosure.", "It should be understood that devices described in the exemplary embodiments can be in communication with each other via various wireless and/or wired methodologies.", "The methodologies can be links that are described as coupled, connected and so forth, which can include unidirectional and/or bidirectional communication over wireless paths and/or wired paths that utilize one or more of various protocols or methodologies, where the coupling and/or connection can be direct (e.g., no intervening processing device) and/or indirect (e.g., an intermediary processing device such as a router).", "FIG.", "7 depicts an exemplary diagrammatic representation of a machine in the form of a computer system 700 within which a set of instructions, when executed, may cause the machine to perform any one or more of the methods described above.", "One or more instances of the machine can operate, for example, as the selective paging application server 118, 218, the RAN cell-site database 120, 220, the base transceiver stations 106, 206, the wireless communication devices, 110, 210, the server 140, 240, the BMSC 122, 222, the MBMS-GW 124, 224, and any of the network nodes, such as the MME 226, the SGW 230, the PGW or equipment of the content data network 234 and other devices of FIGS.", "1-2.In some embodiments, the machine may be connected (e.g., using a network 726) to other machines.", "In a networked deployment, the machine may operate in the capacity of a server or a client user machine in a server-client user network environment, or as a peer machine in a peer-to-peer (or distributed) network environment.", "The machine may comprise a server computer, a client user computer, a personal computer (PC), a tablet, a smart phone, a laptop computer, a desktop computer, a control system, a network router, switch or bridge, or any machine capable of executing a set of instructions (sequential or otherwise) that specify actions to be taken by that machine.", "It will be understood that a communication device of the subject disclosure includes broadly any electronic device that provides voice, video or data communication.", "Further, while a single machine is illustrated, the term “machine” shall also be taken to include any collection of machines that individually or jointly execute a set (or multiple sets) of instructions to perform any one or more of the methods discussed herein.", "The computer system 700 may include a processor (or controller) 702 (e.g., a central processing unit (CPU)), a graphics processing unit (GPU, or both), a main memory 704 and a static memory 706, which communicate with each other via a bus 708.The computer system 700 may further include a display unit 710 (e.g., a liquid crystal display (LCD), a flat panel, or a solid state display).", "The computer system 700 may include an input device 712 (e.g., a keyboard), a cursor control device 714 (e.g., a mouse), a disk drive unit 716, a signal generation device 718 (e.g., a speaker or remote control) and a network interface device 720.In distributed environments, the embodiments described in the subject disclosure can be adapted to utilize multiple display units 710 controlled by two or more computer systems 700.In this configuration, presentations described by the subject disclosure may in part be shown in a first of the display units 710, while the remaining portion is presented in a second of the display units 710.The disk drive unit 716 may include a tangible computer-readable storage medium 722 on which is stored one or more sets of instructions (e.g., software 724) embodying any one or more of the methods or functions described herein, including those methods illustrated above.", "The instructions 724 may also reside, completely or at least partially, within the main memory 704, the static memory 706, and/or within the processor 702 during execution thereof by the computer system 700.The main memory 704 and the processor 702 also may constitute tangible computer-readable storage media.", "Dedicated hardware implementations including, but not limited to, application specific integrated circuits, programmable logic arrays and other hardware devices can likewise be constructed to implement the methods described herein.", "Application specific integrated circuits and programmable logic array can use downloadable instructions for executing state machines and/or circuit configurations to implement embodiments of the subject disclosure.", "Applications that may include the apparatus and systems of various embodiments broadly include a variety of electronic and computer systems.", "Some embodiments implement functions in two or more specific interconnected hardware modules or devices with related control and data signals communicated between and through the modules, or as portions of an application-specific integrated circuit.", "Thus, the example system is applicable to software, firmware, and hardware implementations.", "In accordance with various embodiments of the subject disclosure, the operations or methods described herein are intended for operation as software programs or instructions running on or executed by a computer processor or other computing device, and which may include other forms of instructions manifested as a state machine implemented with logic components in an application specific integrated circuit or field programmable gate array.", "Furthermore, software implementations (e.g., software programs, instructions, etc.)", "including, but not limited to, distributed processing or component/object distributed processing, parallel processing, or virtual machine processing can also be constructed to implement the methods described herein.", "It is further noted that a computing device such as a processor, a controller, a state machine or other suitable device for executing instructions to perform operations or methods may perform such operations directly or indirectly by way of one or more intermediate devices directed by the computing device.", "While the tangible computer-readable storage medium 722 is shown in an example embodiment to be a single medium, the term “tangible computer-readable storage medium” should be taken to include a single medium or multiple media (e.g., a centralized or distributed database, and/or associated caches and servers) that store the one or more sets of instructions.", "The term “tangible computer-readable storage medium” shall also be taken to include any non-transitory medium that is capable of storing or encoding a set of instructions for execution by the machine and that cause the machine to perform any one or more of the methods of the subject disclosure.", "The term “non-transitory” as in a non-transitory computer-readable storage includes without limitation memories, drives, devices and anything tangible but not a signal per se.", "The term “tangible computer-readable storage medium” shall accordingly be taken to include, but not be limited to: solid-state memories such as a memory card or other package that houses one or more read-only (non-volatile) memories, random access memories, or other re-writable (volatile) memories, a magneto-optical or optical medium such as a disk or tape, or other tangible media which can be used to store information.", "Accordingly, the disclosure is considered to include any one or more of a tangible computer-readable storage medium, as listed herein and including art-recognized equivalents and successor media, in which the software implementations herein are stored.", "Although the present specification describes components and functions implemented in the embodiments with reference to particular standards and protocols, the disclosure is not limited to such standards and protocols.", "Each of the standards for Internet and other packet switched network transmission (e.g., TCP/IP, UDP/IP, HTML, HTTP) represent examples of the state of the art.", "Such standards are from time-to-time superseded by faster or more efficient equivalents having essentially the same functions.", "Wireless standards for device detection (e.g., RFID), short-range communications (e.g., Bluetooth®, WiFi, Zigbee®), and long-range communications (e.g., WiMAX, GSM, CDMA, LTE) can be used by computer system 700.In one or more embodiments, information regarding use of services can be generated including services being accessed, media consumption history, user preferences, and so forth.", "This information can be obtained by various methods including user input, detecting types of communications (e.g., video content vs. audio content), analysis of content streams, and so forth.", "The generating of this information can be responsive to an authorization provided by the user.", "The illustrations of embodiments described herein are intended to provide a general understanding of the structure of various embodiments, and they are not intended to serve as a complete description of all the elements and features of apparatus and systems that might make use of the structures described herein.", "Many other embodiments will be apparent to those of skill in the art upon reviewing the above description.", "The exemplary embodiments can include combinations of features and/or steps from multiple embodiments.", "Other embodiments may be utilized and derived therefrom, such that structural and logical substitutions and changes may be made without departing from the scope of this disclosure.", "Figures are also merely representational and may not be drawn to scale.", "Certain proportions thereof may be exaggerated, while others may be minimized Accordingly, the specification and drawings are to be regarded in an illustrative rather than a restrictive sense.", "Although specific embodiments have been illustrated and described herein, it should be appreciated that any arrangement which achieves the same or similar purpose may be substituted for the embodiments described or shown by the subject disclosure.", "The subject disclosure is intended to cover any and all adaptations or variations of various embodiments.", "Combinations of the above embodiments, and other embodiments not specifically described herein, can be used in the subject disclosure.", "For instance, one or more features from one or more embodiments can be combined with one or more features of one or more other embodiments.", "In one or more embodiments, features that are positively recited can also be negatively recited and excluded from the embodiment with or without replacement by another structural and/or functional feature.", "The steps or functions described with respect to the embodiments of the subject disclosure can be performed in any order.", "The steps or functions described with respect to the embodiments of the subject disclosure can be performed alone or in combination with other steps or functions of the subject disclosure, as well as from other embodiments or from other steps that have not been described in the subject disclosure.", "Further, more than or less than all of the features described with respect to an embodiment can also be utilized.", "Less than all of the steps or functions described with respect to the exemplary processes or methods can also be performed in one or more of the exemplary embodiments.", "Further, the use of numerical terms to describe a device, component, step or function, such as first, second, third, and so forth, is not intended to describe an order or function unless expressly stated so.", "The use of the terms first, second, third and so forth, is generally to distinguish between devices, components, steps or functions unless expressly stated otherwise.", "Additionally, one or more devices or components described with respect to the exemplary embodiments can facilitate one or more functions, where the facilitating (e.g., facilitating access or facilitating establishing a connection) can include less than every step needed to perform the function or can include all of the steps needed to perform the function.", "In one or more embodiments, a processor (which can include a controller or circuit) has been described that performs various functions.", "It should be understood that the processor can be multiple processors, which can include distributed processors or parallel processors in a single machine or multiple machines.", "The processor can be used in supporting a virtual processing environment.", "The virtual processing environment may support one or more virtual machines representing computers, servers, or other computing devices.", "In such virtual machines, components such as microprocessors and storage devices may be virtualized or logically represented.", "The processor can include a state machine, application specific integrated circuit, and/or programmable gate array including a Field PGA.", "In one or more embodiments, when a processor executes instructions to perform “operations”, this can include the processor performing the operations directly and/or facilitating, directing, or cooperating with another device or component to perform the operations.", "The Abstract of the Disclosure is provided with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.", "In addition, in the foregoing Detailed Description, it can be seen that various features are grouped together in a single embodiment for the purpose of streamlining the disclosure.", "This method of disclosure is not to be interpreted as reflecting an intention that the claimed embodiments require more features than are expressly recited in each claim.", "Rather, as the following claims reflect, inventive subject matter lies in less than all features of a single disclosed embodiment.", "Thus the following claims are hereby incorporated into the Detailed Description, with each claim standing on its own as a separately claimed subject matter." ] ]
Patent_15874297
[ [ "ACCESS TO NETWORK CONTENT", "A method and system for improving access to search results are provided in the disclosure herein.", "Aspects of this disclosure minimize the delay in accessing network content by priming certain regularly viewed content (e.g., a web search home page or a search results page) in an invisible browser instance.", "As the user accesses the content prerendered in the invisible browser instance, a new instance of the prerendered content is created to facilitate future accesses to the network content (e.g., future search queries)." ], [ "1.", "(canceled) 2.A method for accessing network content, comprising: receiving a request to navigate to a network address; receiving content from the network address and a tag associated with the content from the network address, the tag indicating another network address; controlling, by one or more processors, display of the content associated with the network address in a browser instance; in response to receiving the tag, the one or more processors prefetching resources necessary for prerendering content from the another network address; prerendering, by the one or more processors, content associated with the another network address based on the resources; and storing the prerendered content of the another network address in a hidden browser instance.", "3.The method of claim 2, wherein the content from the network address is search result content and the content from the another network address is content indicated by the search result content.", "4.The method of claim 2, wherein the resources include at least one of executable code, scripting language, multimedia files, or interactive objects.", "5.The method of claim 2, wherein the content of the another network address includes a request to redirect to content from a third network address and the method further comprises: prerendering the content from the third network address to generate prerendered content of the third network address; and storing the prerendered content of the third network address in the hidden browser instance in place of the prerendered content of the another network address.", "6.The method of claim 2, wherein when the hidden browser instance is not accessed within a predetermined time period, the method further comprises discarding the prerendered content of the another network address.", "7.The method of claim 6, wherein the predetermined time period is indicated by the tag.", "8.The method of claim 2, further comprising interfacing with the hidden browser instance through an application programming interface (API).", "9.An apparatus for accessing network content, comprising: at least one processor; and at least one memory coupled to the at least one processor; wherein the at least one processor is configured to control execution of a browser application in accordance with instructions stored in the at least one memory, and the browser application is operable to receive a request to navigate to a network address; receive content from the network address and a tag associated with the content from the network address, the tag indicating another network address; control display of the content associated with the network address in a browser instance; in response to receiving the tag, prefetch resources necessary for prerendering content from the another network address; prerender content associated with the another network address based on the resources to generate prerendered content of the another network address; and store the prerendered content of the another network address in a hidden browser instance.", "10.The apparatus of claim 9, further comprising a display for displaying the content associated with the network address and the content associated with the another network address.", "11.The apparatus of claim 9, wherein the content from the network address is search result content and the content from the another network address is content indicated by the search result content.", "12.The apparatus of claim 9, wherein the resources include at least one of executable code, scripting language, multimedia files, or interactive objects.", "13.The apparatus of claim 9, wherein the content of the another network address includes a request to redirect to content from a third network address, and the browser application prerenders the content from the third network address to generate prerendered content of the third network address and stores the prerendered content of the third network address in the hidden browser instance in place of the prerendered content of the another network address.", "14.The apparatus of claim 9, wherein the browser application is further operable to discard the prerendered content of the another network address when the hidden browser instance is not accessed within a predetermined time period.", "15.The apparatus of claim 14, wherein the predetermined time period is indicated by the tag.", "16.The apparatus of claim 9, wherein the browser application is further operable to interface with the hidden browser instance through an application programming interface (API).", "17.A non-transitory computer-readable medium having instructions stored thereon, the instructions, when executed by one or more processors, cause the one or more processors to implement a method for accessing network content, the method comprising: receiving a request to navigate to a network address; receiving content from the network address and a tag associated with the content from the network address, the tag indicating another network address; controlling, by the one or more processors, display of the content associated with the network address in a browser instance; in response to receiving the tag, the one or more processors prefetching resources necessary for prerendering content from the another network address; prerendering, by the one or more processors, content associated with the another network address based on the resources to generate prerendered content of the another network address; and storing the prerendered content of the another network address in a hidden browser instance.", "18.The medium of claim 17, wherein the content from the network address is search result content and the content from the another network address is content indicated by the search result content.", "19.The medium of claim 17 wherein the resources include at least one of executable code, scripting language, multimedia files, or interactive objects.", "20.The medium of claim 17, wherein the content of the another network address includes a request to redirect to content from a third network address and the method further comprises: prerendering the content from the third network address to generate prerendered content of the third network address: and storing the prerendered content of the third network address in the hidden browser instance in place of the prerendered content of the another network address.", "21.The medium of claim 17 wherein when the hidden browser instance is not accessed within a predetermined time period, the method further comprises discarding the prerendered content of the another network address." ], [ "<SOH> BACKGROUND <EOH>The advent of the World Wide Web has placed more information at the fingertips of today's users than ever before.", "Various websites cater to nearly every need and interest, providing access to reference information, business and financial documents, social networking, and more.", "Widespread broadband Internet access provides faster access to these sites than ever before.", "However, as fast as current high-speed Internet services are, the act of browsing the web is not instantaneous.", "When a user selects a link on a page or enters a uniform resource locator (URL) in a text field, there is a delay while data is requested from the host, sent to the client, and rendered in the browser.", "The user is typically idle while waiting for their requested site to load.", "While high-speed Internet access may limit this delay to a few seconds, even this short delay can add up to thousands of man-hours of lost productivity each year." ], [ "<SOH> BRIEF SUMMARY <EOH>A method and system for improving access to network content are provided in the disclosure herein.", "Aspects of this disclosure minimize the delay in accessing network content by prerendering elements of a content page.", "The network content, such a web search results page or a web search home page, may be prerendered in a hidden browser instance when the browser is executed.", "Aspects of the disclosure may provide a search query to the network content via an application programming interface (API) such as a search API.", "The prerendered network content may be made visible in response to a selection operation indicating that the user wishes to access the prerendered network content (e.g., selection of web search home page by entering the web search home page's address, selection of a home page button where the home page of the browser is set to web search home pages, or entry of a search query), thus allowing for immediate display of the network content.", "After the user accesses the prerendered network content, a new instance of the network content may be prerendered.", "For example, when the user performs a search query, a new instance of a search page may be prerendered after the original prerendered search page is merged with the visible browser instance to prepare for a future search query.", "Aspects of the disclosure describe a computer-implemented method for improving access to network content.", "The method may include prerendering, using a processor, a set of network content in a hidden browser instance, monitoring user input in a browser for a selection operation associated with the set of network content preloaded in the hidden browser instance, detecting the selection operation associated with the set of network content preloaded in the hidden browser instance, in response to a detection of the selection operation, merging, with the processor, the set of network content into an active browser instance, and creating a new instance of the set of network content in a new hidden browser instance for use in another selection operation associated with the set of network content.", "The set of network content may be a search results page and the selection operation may be at least one of entry of a search query in a text entry field or selection of a suggested search query.", "The set of network content may be a web search home page and the selection operation may indicate that the user wishes to access the web search home page.", "Prerendering the set of network content may include requesting the set of network content from a remote server.", "The new instance of the set of network content may be created by copying the set of network content received from the remote server without contacting the remote server a second time.", "The new instance of the set of network content may be created at a particular time interval after the selection operation.", "The new instance of the set of network content may be created based on a parameter received from a remote server that provided the network content.", "The new instance of the set of network content may be created immediately after the set of network content is merged with the active browser instance.", "The method may include notifying the set of network content preloaded in the hidden browser instance of the selection operation using an application programming interface.", "The set of network content may be determined by at least one of a user preference, a user navigation history, or a default search engine.", "Aspects of the disclosure may provide a non-transitory computer readable storage medium containing instructions that, when executed by a processor, cause the processor to perform a method.", "The method performed by the processor may include prerendering, using a processor, a set of network content in a hidden browser instance, monitoring user input in a browser for a selection operation associated with the set of network content preloaded in the hidden browser instance, detecting the selection operation associated with the set of network content preloaded in the hidden browser instance, in response to a detection of the selection operation, merging the set of network content into an active browser instance, and creating a new instance of the set of network content in a new hidden browser instance for use in another selection operation associated with the set of network content.", "The set of network content may be a search engine web page and the selection operation may be at least one of entry of a search query in a text entry field or selection of a suggested search query.", "The set of network content may be a web search home page and the selection operation indicates that the user wishes to access the web search home page.", "Prerendering the set of network content may include requesting the set of network content from a remote server.", "The new instance of the set of network content may be created by copying the set of network content received from the remote server without contacting the remote server a second time.", "The new instance of the set of network content may be created at a particular time interval after the selection operation.", "The new instance of the set of network content may be created based on a parameter received from a remote server that provided the network content.", "The new instance of the set of network content may be created immediately after the set of network content is merged with the active browser instance.", "The method may include notifying the set of network content preloaded in the hidden browser instance of the selection operation using an application programming interface.", "The set of network content may be determined by at least one of a user preference, a user navigation history, or a default search engine.", "Aspects of the disclosure may provide a processing system for improving access to search results.", "The processing system may include at least one processor, and a memory coupled to the at least one processor.", "The processor may be configured to execute a browser application, prerender a set of network content in a hidden instance of the browser application, such that at least some portion of the network content is rendered, monitor user input in the browser for a selection operation associated with the set of network content preloaded in the hidden browser instance, detect the selection operation associated with the set of network content preloaded in the hidden browser instance, in response to a detection of the selection operation, merge the set of network content into an active browser instance, and create a new instance of the set of network content in a new hidden browser instance for use in another selection operation associated with the set of network content.", "The set of network content may be at least one of a web search home page or a search results page.", "The selection operation may be at least one of entry of a search query in a text field or selection of a suggested search query." ], [ "CROSS-REFERENCES TO RELATED APPLICATIONS The present application is a continuation of U.S. patent application Ser.", "No.", "13/472,019, filed on May 15, 2012, the disclosure of which is hereby incorporated herein by reference.", "BACKGROUND The advent of the World Wide Web has placed more information at the fingertips of today's users than ever before.", "Various websites cater to nearly every need and interest, providing access to reference information, business and financial documents, social networking, and more.", "Widespread broadband Internet access provides faster access to these sites than ever before.", "However, as fast as current high-speed Internet services are, the act of browsing the web is not instantaneous.", "When a user selects a link on a page or enters a uniform resource locator (URL) in a text field, there is a delay while data is requested from the host, sent to the client, and rendered in the browser.", "The user is typically idle while waiting for their requested site to load.", "While high-speed Internet access may limit this delay to a few seconds, even this short delay can add up to thousands of man-hours of lost productivity each year.", "BRIEF SUMMARY A method and system for improving access to network content are provided in the disclosure herein.", "Aspects of this disclosure minimize the delay in accessing network content by prerendering elements of a content page.", "The network content, such a web search results page or a web search home page, may be prerendered in a hidden browser instance when the browser is executed.", "Aspects of the disclosure may provide a search query to the network content via an application programming interface (API) such as a search API.", "The prerendered network content may be made visible in response to a selection operation indicating that the user wishes to access the prerendered network content (e.g., selection of web search home page by entering the web search home page's address, selection of a home page button where the home page of the browser is set to web search home pages, or entry of a search query), thus allowing for immediate display of the network content.", "After the user accesses the prerendered network content, a new instance of the network content may be prerendered.", "For example, when the user performs a search query, a new instance of a search page may be prerendered after the original prerendered search page is merged with the visible browser instance to prepare for a future search query.", "Aspects of the disclosure describe a computer-implemented method for improving access to network content.", "The method may include prerendering, using a processor, a set of network content in a hidden browser instance, monitoring user input in a browser for a selection operation associated with the set of network content preloaded in the hidden browser instance, detecting the selection operation associated with the set of network content preloaded in the hidden browser instance, in response to a detection of the selection operation, merging, with the processor, the set of network content into an active browser instance, and creating a new instance of the set of network content in a new hidden browser instance for use in another selection operation associated with the set of network content.", "The set of network content may be a search results page and the selection operation may be at least one of entry of a search query in a text entry field or selection of a suggested search query.", "The set of network content may be a web search home page and the selection operation may indicate that the user wishes to access the web search home page.", "Prerendering the set of network content may include requesting the set of network content from a remote server.", "The new instance of the set of network content may be created by copying the set of network content received from the remote server without contacting the remote server a second time.", "The new instance of the set of network content may be created at a particular time interval after the selection operation.", "The new instance of the set of network content may be created based on a parameter received from a remote server that provided the network content.", "The new instance of the set of network content may be created immediately after the set of network content is merged with the active browser instance.", "The method may include notifying the set of network content preloaded in the hidden browser instance of the selection operation using an application programming interface.", "The set of network content may be determined by at least one of a user preference, a user navigation history, or a default search engine.", "Aspects of the disclosure may provide a non-transitory computer readable storage medium containing instructions that, when executed by a processor, cause the processor to perform a method.", "The method performed by the processor may include prerendering, using a processor, a set of network content in a hidden browser instance, monitoring user input in a browser for a selection operation associated with the set of network content preloaded in the hidden browser instance, detecting the selection operation associated with the set of network content preloaded in the hidden browser instance, in response to a detection of the selection operation, merging the set of network content into an active browser instance, and creating a new instance of the set of network content in a new hidden browser instance for use in another selection operation associated with the set of network content.", "The set of network content may be a search engine web page and the selection operation may be at least one of entry of a search query in a text entry field or selection of a suggested search query.", "The set of network content may be a web search home page and the selection operation indicates that the user wishes to access the web search home page.", "Prerendering the set of network content may include requesting the set of network content from a remote server.", "The new instance of the set of network content may be created by copying the set of network content received from the remote server without contacting the remote server a second time.", "The new instance of the set of network content may be created at a particular time interval after the selection operation.", "The new instance of the set of network content may be created based on a parameter received from a remote server that provided the network content.", "The new instance of the set of network content may be created immediately after the set of network content is merged with the active browser instance.", "The method may include notifying the set of network content preloaded in the hidden browser instance of the selection operation using an application programming interface.", "The set of network content may be determined by at least one of a user preference, a user navigation history, or a default search engine.", "Aspects of the disclosure may provide a processing system for improving access to search results.", "The processing system may include at least one processor, and a memory coupled to the at least one processor.", "The processor may be configured to execute a browser application, prerender a set of network content in a hidden instance of the browser application, such that at least some portion of the network content is rendered, monitor user input in the browser for a selection operation associated with the set of network content preloaded in the hidden browser instance, detect the selection operation associated with the set of network content preloaded in the hidden browser instance, in response to a detection of the selection operation, merge the set of network content into an active browser instance, and create a new instance of the set of network content in a new hidden browser instance for use in another selection operation associated with the set of network content.", "The set of network content may be at least one of a web search home page or a search results page.", "The selection operation may be at least one of entry of a search query in a text field or selection of a suggested search query.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a system diagram depicting an example of a server in communication with example client devices in accordance with aspects of the disclosure.", "FIG.", "2 is block diagram depicting an example of a computing device in accordance with aspects of the disclosure.", "FIG.", "3 is a flow diagram depicting an example method for prerendering network content in accordance with aspects of the disclosure.", "FIG.", "4 is a flow diagram depicting an example method for priming a hidden browser instance with network content in accordance with aspects of the disclosure.", "FIG.", "5 is a screen capture of an example of a browser window showing the use of a text entry field for entering a search query or an address in accordance with aspects of the disclosure.", "FIG.", "6 is a screen capture of an example of a search page in accordance with aspects of the disclosure.", "FIG.", "7 is a flow diagram depicting an example of a method for prerendering a search page to improve access to search results in accordance with aspects of the invention.", "DETAILED DESCRIPTION A method and system for improving access to search results are provided in the disclosure herein.", "Aspects of this disclosure minimize the delay in accessing network content by “priming” certain regularly viewed content (e.g., a web search home page or a search results page) in an invisible browser instance.", "As the user accesses the content prerendered in the invisible browser instance, a new instance of the prerendered content is created to facilitate future accesses to the network content (e.g., future search queries).", "Aspects of the disclosure may provide a search query to a preloaded search page via a search application programming interface.", "The preloaded search web page may be made visible in response to the search query such that the user does not need to wait for rendering of the web page (e.g., fetching and rendering of page formatting, logos, scripts, and the like), thus allowing for immediate display of search results as soon as the results are received.", "Various methods for performing the prerendering operation, configuring the prerendering operation, and managing the prerendering operation are described.", "For the purposes of this application, the term “prerendering” generally refers to the act of requesting all resources (e.g., any executable code, scripting language, files, and/or interactive objects) necessary to load the content of a web address, and loading the content in a web browser instance.", "As shown in FIG.", "1, an example system 102 in accordance with one aspect includes a server 104 in communication with one or more client devices 106, 108, 110 displaying web browser interfaces 114, 116, 118.The user of the client device 106 may browse to a web page located at “www.a.com” as displayed on the web browser interface 114.That page includes content selectable by the user.", "The client devices may be any device capable of managing data requests via a network 112.Examples of such client devices include a personal computer (PC) 108, a mobile device 110, or a server 106.The client devices 106, 108, 110 are operable to perform prerendering operations during the execution of a web browser application.", "In some aspects, the client devices 106, 108, 110 predict a search event by identifying cursor placement, text entry, or interface focus.", "The prerender operation may also be determined dynamically by, for example, a JAVASCRIPT code.", "While the concepts described herein are generally described with respect to a web browser interface 114, 116, 118 executing on a client device 106, 108, 110, aspects of the disclosure can also be applied to any computing node capable of managing navigation events over a network, including a server 104.The client devices 106, 108, 110 may also comprise personal computers, personal digital assistants (“PDA”): tablet PCs, netbooks, laptops, mobile phones, etc.", "Indeed, client devices in accordance with the systems and methods described herein may comprise any device operative to process instructions and transmit data to and from humans and other computers including general purpose computers, network computers lacking local storage capability, etc.", "The client devices 106, 108, 110 may be operable to predict search operations to assist in data access on the network 112.For example, the client devices may predict a search operation to facilitate prerendering of a search page in order to decrease delay in the display of network content, thus improving the user's browsing experience.", "In some aspects, the server 104 provides navigation data which may be used by the client devices 106, 108, 110 to predict a search operation.", "In some aspects, the client devices 106, 108, 110 predict a search operation using local data.", "The network 112, and the intervening nodes between the server 104 and the client devices 106, 108, 110, may comprise various configurations and use various protocols including the Internet, World Wide Web, intranets, virtual private networks, local Ethernet networks, private networks using communication protocols proprietary to one or more companies, cellular and wireless networks (e.g., Wi-Fi), instant messaging, hypertext transfer protocol (“HTTP”) and simple mail transfer protocol (“SMTP”), and various combinations of the foregoing.", "It should be appreciated that a typical system may include a large number of connected computers.", "Although certain advantages are obtained when information is transmitted or received as noted above, other aspects of the system and method are not limited to any particular manner of transmission of information.", "For example, in some aspects, information may be sent via a medium such as an optical disk or portable drive.", "In other aspects, the information may be transmitted in a non-electronic format and manually entered into the system.", "Although some functions are indicated as taking place on the server 104 and other functions are indicated as taking place on the client devices 106, 108, 110, various aspects of the system and method may be implemented by a single computer having a single processor.", "It should be appreciated that aspects of the system and method described with respect to the client may be implemented on the server, and vice-versa.", "FIG.", "2 is a block diagram depicting an example of a computing device 200, such as one of the client devices 106, 108, 110 described with respect to FIG.", "1.The computing device 200 may include a processor 204, a memory 202 and other components typically present in general purpose computers.", "The memory 202 may store instructions 206 and data 208 that are accessible by the processor 204.The processor 204 may execute the instructions 206 and access the data 208 to control the operations of the computing device 200.The memory 202 may be any type of tangible memory operative to store information accessible by the processor 204, including a computer-readable medium, or other medium that stores data that may be read with the aid of an electronic device, such as a hard-drive, memory card, read-only memory (“ROM”), random access memory (“RAM”), digital versatile disc (“DVD”) or other optical disks, as well as other write-capable and read-only memories.", "The system and method may include different combinations of the foregoing, whereby different portions of the instructions and data are stored on different types of media.", "The instructions 206 may be any set of instructions to be executed directly (such as machine code) or indirectly (such as scripts) by the processor 204.For example, the instructions may be stored as computer code on a computer-readable medium.", "In that regard, the terms “instructions” and “programs” may be used interchangeably herein.", "The instructions 206 may be stored in object code format for direct processing by the processor 204, or in any other computer language including scripts or collections of independent source code modules that are interpreted on demand or compiled in advance.", "Functions, methods and routines of the instructions 206 are explained in more detail below (see FIGS.", "3-7).", "The data 208 may be retrieved, stored or modified by the processor 204 in accordance with the instructions 206.For instance, although the architecture is not limited by any particular data structure, the data 208 may be stored in computer registers, in a relational database as a table having a plurality of different fields and records, Extensible Markup Language (“XML”) documents or flat files.", "The data may also be formatted in any computer readable format such as, but not limited to, binary values or Unicode.", "By further way of example only, image data may be stored as bitmaps comprised of grids of pixels that are stored in accordance with formats that are compressed or uncompressed, lossless (e.g., BMP) or lossy (e.g., JPEG), and bitmap or vector-based (e.g., SVG), as well as computer instructions for drawing graphics.", "The data 208 may comprise any information sufficient to identify the relevant information, such as numbers, descriptive text, proprietary codes, references to data stored in other areas of the same memory or different memories (including other network locations) or information that is used by a function to calculate the relevant data.", "The processor 204 may be any suitable processor, such as various commercially available general purpose processors.", "Alternatively, the processor 204 may be a dedicated controller such as an application-specific integrated circuit (“ASIC”).", "Although FIG.", "2 functionally illustrates the processor and memory as being within a single block, it should be understood that the processor 204 and memory 202 may actually comprise multiple processors and memories that may or may not be stored within the same physical housing.", "Accordingly, references to a processor, computer or memory will be understood to include references to a collection of processors, computers or memories that may or may not operate in parallel.", "The computing device 200 may be at one node of a network and be operative to directly and indirectly communicates with other nodes of the network.", "For example, the computing device 200 may comprise a web server that is operative to communicate with client devices via the network such that the computing device 200 uses the network to transmit and display information to a user on a display of the client device.", "The system can provide privacy protections for the client data including, for example, anonymization of personally identifiable information, aggregation of data, filtering of sensitive information, encryption, hashing or filtering of sensitive information to remove personal attributes, time limitations on storage of information, and/or limitations on data use or sharing.", "Data can be anonymized and aggregated such that individual client data is not revealed.", "A user may also be provided with an opportunity to opt in/out to enable the collection of sharing of data.", "In order to facilitate the prerendering and search operations of the computing device 200, the memory 202 may further comprise a browser 2102.Although the browser 210 is identified as a discrete module in connection with FIG.", "2, the functionality of this module may overlap and/or exist in a fewer or greater number of modules than what is shown, with such modules residing at one or more processing devices, which may be geographically dispersed.", "The browser 210 provides for the display of network content, such as a web page, to a user of the client device via a visible browser instance 212 by sending and receiving data across a computer network.", "The network content may be received in response to a network request, such as a Hypertext Transfer Protocol (HTTP) GET request.", "The network content may be provided in a markup language, such as Hypertext Markup Language (HTML).", "The network content may also include various scripts, data, forms, and the like viewable and/or executed in the visible browser instance 212, including interactive and/or executable content such as ADOBE FLASH content, JAVASCRIPT content, and the like.", "The browser 210 may further comprise a hidden browser instance 214.The hidden browser instance 214 provides a browser instance within which network content identified by a prerender controller 218 may be loaded.", "The network content identified by the prerender controller 218 may take the form of content that the user is likely to access during a browser session, such as a web page for initiating a search query or displaying search results, a user webmail page, or any other content that a user is likely to return to one or more times during the browsing session.", "The hidden browser instance 214 may include a start page for a search engine wherein non-search-result data (e.g., page formatting, logos, images, style sheets, scripts, and the like) has been requested and rendered by the prerender module 210.The preloaded search page may be stored such that the preloaded search page is not visible to a user until the user provides a search query.", "The hidden rendering environment refers to any representation that does not have an immediately apparent interface for the user.", "For example, the preloaded search page may be stored within a browser “tab” that does not have an associated selection control in a web browser tab interface.", "The hidden browser instance 214 may be accessible via a menu or interface command, and in response to the selection of this interface command an interface for the prerendered content is generated, such as by adding a selection control for the prerendered content to the browser tab interface.", "The hidden rendering environment may also be provided by a variety of other methods suitable to receive and render the page environment while avoiding distraction of the user with potentially irrelevant content.", "The network content loaded in the hidden browser instance 214 may be stored in a completely executed and rendered format.", "For example, any executable code, scripting language, multimedia files, and/or interactive objects may be fully requested and loaded in the prerendering environment provided by the hidden browser instance.", "Where the hidden browser instance 214 stores a preloaded search page, if the user enters a search query, the browser 210 may execute the search query using the preloaded search page, and merge the preloaded search page with the visible browser instance 212.Search results responsive to the search query may thus be provided without the need to request the search engine page or wait for the search engine page to render.", "Throughout this process the preloaded search page may issue the query over the network to the search engine, receive data providing results for the search query, blend the results into the preloaded search page, and make itself visible.", "The prerender controller 218 may control preloading and prerendering operations performed within the web browser.", "For example, after a preloaded search page is merged with the visible browser instance 212, the prerender controller 218 may reprime the hidden browser instance 214 with a new instance of the preloaded search page to prepare for a new search query.", "The prerender controller 218 may perform these operations at particular intervals, such as on a timer (e.g., every 30 seconds), instantly upon merging the hidden browser instance with the visible browser instance, in response to network traffic, or in response to an indication from the server hosting the network content.", "The prerender controller 218 may also be configured by prerender configuration settings 220.These prerender configuration settings 220 may control when and how the prerender controller performs prerender operations.", "For example, the prerender configuration settings 220 may specify a particular set of network content (e.g., a URL) to be preloaded in the hidden browser instance 214, such as a web search home page, a user webmail access page, or a search results page.", "The prerender configuration settings 220 may also specify a frequency with which to prerender (e.g., a time interval to reprime the hidden browser instance after merging with the visible browser instance), a system resource level to perform preloading, or any other setting to assist the user with adjusting the prerendering operations to meet a particular set of needs or preferences.", "The web browser 210 may further comprise a search application programming interface (API) 216.Although the specific example described herein relates to the use of a search API for interfacing with a preloaded search page loaded in the hidden browser instance 214, the same concepts may apply to the use of other page APIs, such as a user homepage or webmail page configured to accept commands or instructions via other APIs.", "The search API 216 allows for a scripted interface with the content loaded in the hidden browser instance 214.When the browser 210210 detects a search query (e.g., entered into a text field provided by the browser), the browser 210 may pass the search query to the preloaded search page using the search API 216.For example, the search query may be passed to the preloaded search page using an asynchronous JavaScript and extensible markup language (AJAX) protocol.", "The network content stored within the hidden browser instance 214 may be specifically configured to communicate in this manner, allowing the client computing device 200 to interface with the network content without the need to navigate to a new URL to perform the action (e.g., to provide a search query to a preloaded search page).", "The search API 216 may be configurable within the browser 210.For example, a user may specify a particular search engine for use in search operations performed by the browser.", "FIG.", "3 is a flow diagram depicting an example method 300 for prerendering a web page, such as network content executed stored within the hidden browser instance 214, in accordance with aspects of the disclosure.", "Aspects of the method 300 operate to minimize load times for network content by requesting the network content prior to the user navigating to said network content.", "The method 300 may be performed by a computing device, such as the computing device 200, to eliminate delays in the user search experience by prerendering a search page in a hidden browser instance prior to the user entering a search query.", "For example, the method 300 may be performed by elements of the browser 210.While aspects of the method 300 are described with respect to the computing device 200, the method 300 may also be performed by the server 104, or any device with hardware and/or software designed to accept instructions.", "At stage 302, the computing device 200 determines a next navigation event, such as a search operation, within a web browser.", "The next navigation event may be received from a navigation prediction element, or the next navigation event may be embedded within the web page displaying within the web browser.", "For example, a search engine may embed a tag within a set of search results to indicate that a particular link associated with the most relevant result should be prerendered by the web browser.", "A method for embedding prerendering tags within a web page is described below (see FIG.", "4).", "At stage 304, the computing device 200 requests the content associated with the navigation event or search page identified at stage 302.The request may comprise a hypertext transfer protocol (HTTP) GET request, a file transfer protocol (FTP) request, or any other network data access request as known in the art.", "A first set of web content may be provided in response to a HTTP GET request, which may then lead to additional HTTP GET requests in accordance with the first set of web content.", "For example, a HTTP GET request may result in a base search page being sent to the web browser, which may trigger other page loading operations, such as additional GET requests.", "The base search page may have multiple embedded images, which are then fetched and rendered using HTTP GET requests for each image.", "The prerendering process as described may request the full search page, including associated scripts, and then execute those scripts.", "At stage 306, the computing device 200 renders content associated with the navigation event determined at stage 302.The content may be rendered in an alternate instance of the web browser that is hidden from the user.", "For example, the content may be rendered by an alternate process or in a hidden web browser tab.", "In some aspects, the rendered content may include a redirection operation.", "An example of a redirection operation is when the act of loading a first page, for instance, www.a.com, causes the browser to load a second page, such as www.b.com.", "Redirection may occur in response to a HTML tag, a JAVASCRIPT navigation command, or the like.", "In the case a prerendered page requests a redirection operation, said redirection operation would also occur in the alternate instance.", "In some aspects, a first redirection operation may lead to subsequent redirections.", "For example, www.a.com may lead to www.b.com, which leads to www.c.com.", "Aspects of the system and method may account for this fact, such as by storing a history of redirection operations and prerendering the last page in a series in response to a first page being identified to prerender.", "In some aspects, the method 300 may short-circuit redirection operations by not prerendering intermediate pages when the destination result page (i.e.", "the page at the end of the redirection operations) is known, and only prerendering the final page in the series.", "At stage 308, the computing device 200 may determine whether the user has selected the link identified at stage 302 or performed a search operation within a particular time period.", "For example, the method 300 may wait for 10 seconds, 20 seconds, 30 seconds, one minute, 5 minutes, or any other time frame.", "In some aspects, the time frame may be configurable within an options menu associated with the web browser.", "The time frame may also be specified by the server 104.For example, the server 104 may embed a timeout value within a prerender tag, indicating the length of time the content associated with the tag should be held before being discarded.", "If the user has selected the link within the time period, the method 300 proceeds to stage 312.Otherwise, the method 300 proceeds to stage 310.At stage 310, the computing device 200 discards the prerendered content.", "The prerendered content is allowed to expire in this manner in order to free up system resources associated with the prerender operation and prevent the user from being presented with stale data.", "In some aspects, a different expiration period may be specified for different types of data.", "For example, data that is likely to rapidly change, such as breaking news articles, stock quotes, syndication feeds, and the like, is more likely to grow stale quickly, and might be associated with a shorter expiration timer, such as 10 seconds, 20 seconds, or one minute.", "Data that is less likely to change, such as reference articles, archives, box scores, and the like, might be associated with a longer expiration timer, such as an hour, 6 hours, 24 hours, a week, or the like.", "In some aspects, the wait time is based on a page type.", "For example, if the user is viewing a lengthy news article, a longer wait time may be specified when prerendering a next page of the article to provide the user time to read the current page of the article before selecting the next page.", "In some aspects, the wait time is determined by a time-to-live (TTL) parameter embedded within the page.", "In some aspects, the wait time is hard coded within the browser.", "The method 300 then ends after the prerendered content is discarded, though in some aspects the method 300 may repeat indefinitely as the user browses web content.", "At stage 312, the computing device 200 merges the alternate instance containing the prerendered content into the visible user instance, in response to the user performing a search operation.", "In this manner, the computing device 200 displays the content associated with the navigation event instantly, without a delay while the page data is requested from and received from the host server.", "Search results may be merged into the search page as the results are received from a server.", "In some aspects, the user may select the navigation event prior to the prerendering operation completing.", "In such cases, the partially loaded page would be merged into the current user instance.", "The partially loaded page would then continue to load in the current user instance as normal.", "The method 300 then ends after making the prerendered content available to the user.", "FIG.", "4 is a flow diagram depicting an example method 400 for priming a hidden browser instance with network content in accordance with aspects of the disclosure.", "By preloading regularly accessed content in a hidden browser instance, the method ensures that users experience a minimum of wait time when performing commonly operations such as Internet searches or visits to a web search home page.", "Such commonly viewed content may be “primed” when the browser is first executed to prepare for such access.", "The content that is primed and the manner in which it is accessed may be determined by various methods, including particular configuration settings or preferences.", "At stage 402, the hidden browser instance is primed with the network content.", "As described above, the network content may be associated with commonly performed user activities, such as initiation of a search request, a return to the web search home page, or accessing the user's primary webmail account.", "The content that is primed in this manner may be determined in a variety of methods including allowing the user to specify an address or uniform resource locator (URL) in configuration settings, analysis of user navigation history to predict a most frequently visited page, or specification of a default search engine for priming.", "This initial priming stage may occur when the browser is initially executed.", "At stage 404, an indication that the user wishes to access the network content preloaded in the hidden browser instance is received.", "For example, if the network content is a web search home page, the user may select a “home” interface control.", "If the network content is a search results page, the user may enter a search query in a text entry field or select a suggested search query, such as provided via an “Omnibox” (see FIG.", "5).", "As another example, the user may also indicate a desire to access the network content by typing a URL associated with the content in a browser address bar.", "In response to the selection operation received at stage 404, the hidden browser instance containing the network content is merged into the active browser instance at stage 406.The network content thus becomes accessible to the user as soon as the merge occurs, without the need to request the content from a host server.", "At stage 408, the network content is reprimed (e.g., rendered again) in a hidden browser instance again.", "A new hidden browser instance may be established, or the same hidden instance that previously held the network content may be used for the new content.", "The network content may be requested again over the network, or it may be rendered again using previously requested data.", "In this manner, the network content is prepared for a new user interaction, such as a new search query or a new return to the web search home page.", "The network content may be reprimed after a particular length of time after the initial set of network content is used, for example, a search page may be reprimed 30 seconds after each search query.", "The network content may be reprimed based on other factors as well, such as immediately after use of the initial network content, based upon an access model derived from previous user navigation habits, based on a level of available system resources, or based on an indication from the server hosting for the network content.", "For example, the server may specify a particular “Time to Wait” or “Time to Live” before the network content is reprimed in order to manage the amount of network traffic flowing to the server from preload operations.", "The method 400 may end after the network content has been reprimed for use in another network access operation.", "The repriming operation may be performed in various manners, including copying the preloaded network content before merging the content into the active browser, or requesting a new copy of the network content from a host server.", "FIG.", "5 is a screen capture of an example of a browser window 500 showing the use of a text entry field 402 for entering a search query or an address in accordance with aspects of the disclosure.", "The text entry field 502 shown may function as an “Omnibox”, allowing the user to type in a search query or a website URL.", "If the user enters a website URL, the browser may navigate to the URL.", "If the user does not enter a URL, the browser may present a list of search results associated with the entered text.", "FIG.", "6 is a screen capture of an example of a search page 600 in accordance with aspects of the disclosure.", "The search page 600 is made up of interface controls, images, and formatting data, such as the page header 602, and a set of search results 604.In pages configured to accept search queries via a search API, the search results 604 may be received separately from the rest of the page.", "This allows formatting data, scripts, logos, headers, style sheets, and the like, such as the page header 602, to be loaded independently from the search results 604.As such, page elements other than the search results may be rendered prior to the entry of a search query, allowing for immediate display of search results as they are received in response to a search query.", "Aspects of the disclosure may prerender these page elements in a hidden browser instance to facilitate instant display of search results.", "FIG.", "7 is a flow diagram depicting an example of a method 700 for preloading a search page to improve access to search results in accordance with aspects of the invention.", "The method 700 provides for prerendering of a search engine page in a hidden browser instance.", "When a search query is provided, the query is passed to the prerendered search engine via a search API, and the prerendered search engine is merged into an active browser session.", "In this manner, search results are provided to the user as soon as the results are received from the search engine, with no delay while the search engine page loads.", "As described above, preloaded search pages may be primed to reduce access times to search results, with a new search page preloaded after the previous search page is used to perform a search query (see FIG.", "4).", "At stage 702, the search engine page is prerendered in a hidden browser instance.", "The search engine page may be prerendered in response to user input, or it may be prerendered when the browser is loaded.", "For example, the search engine page may be prerendered when a text entry field that accepts search queries receives focus, when the user enters at least one text character in the text entry field, or after at least one “spacebar” character is entered in the text entry field (to distinguish the text entry from a URL).", "The prerendering process of the search engine may include requesting any or all of page formatting instructions, images, logos, scripts, style sheets, or any other content that must be received in order to render the web page, aside from the search results responsive to the query.", "At stage 704, a search query is received.", "The search query may be received in response to the user entering text in the text field, or the query may be identified after the user performs a selection operation, such as pressing the “enter” key after entering text in the text field.", "The search query may also be identified via other methods, such as by detecting a “spacebar” character in a text entry field.", "In some aspects, the search query is only sent to the search engine after the “enter” key has been pressed and the text string is determined to not be a URL, in order to preserve user privacy (e.g., to avoid sending URLs typed by the user for navigation purposes to the server as search engine queries).", "At stage 706, the search query is passed to the prerendered search engine page.", "The search query may be communicated to the prerendered search page using a search API, where the query is sent via a scripting interface.", "For example, the query may be sent to the search engine via an AJAX interface on the search engine page.", "At stage 708, the prerendered search page is merged into the active browser instance to display the search results.", "Search results may thus be instantly presented to the user as they are received from the search engine server, as the other content of the search engine page has already been rendered.", "The stages of the illustrated methods are not intended to be limiting.", "The functionality of the methods can exist in a fewer or greater number of stages than what is shown and, even with the depicted methods, the particular order of events may be different from what is shown in the figures.", "The systems and methods described herein advantageously provide for faster display of search results.", "Since the non-search-result content of the search engine page is prerendered, delay associated with requesting, downloading, and rendering such content is eliminated.", "This allows display of search results as soon as the results are received from the search engine server.", "Display of search results in such a manner may save multiple seconds of delay during which the user would otherwise be idle while waiting for the page data to render.", "As these and other variations and combinations of the features discussed above can be utilized without departing from the disclosure as defined by the claims, the foregoing description of the embodiments should be taken by way of illustration rather than by way of limitation of the disclosure as defined by the claims.", "It will also be understood that the provision of examples of the disclosure (as well as clauses phrased as “such as,” “e.g.”, “including” and the like) should not be interpreted as limiting the disclosure to the specific examples; rather, the examples are intended to illustrate only some of many possible embodiments." ] ]
Patent_15874301
[ [ "IMAGE PROCESSING METHOD", "A setting circuit sets a quantization value per input image on the basis of a noise value of the whole input image, and a quantization circuit performs quantization on first image data to generate second image data.", "Quantization value based on the noise value the whole input image can realize appropriate denoising depending on the noise level of the whole input image." ], [ "1.An image processing method for denoising of an input image to generate an output image, the method comprising: transforming first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components; calculating a per-block noise value based on the first image data; setting a first quantization value per input image based on a noise value of the whole input image; quantizing the second image data based on the first quantization value to generate third image data with noise in the input image removed; and generating the output image base on the third image data." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>In some embodiments, an image processor performs denoising on an input image to generate an output image.", "The image processor includes a transform circuit that transforms first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including multiple frequency components, a quantization circuit that performs quantization on the second image data to generate third image data, an arithmetic circuit that calculates a per-block activity evaluation value based on the first image data, and a quantization value setting circuit that sets a per-block quantization value for quantization based on the per-block activity evaluation value.", "In some embodiments, an image processor performs denoising on an input image to generate an output image.", "The image processor includes a transform circuit that transforms first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including multiple frequency components, a quantization circuit that performs quantization on the second image data to generate third image data, a first arithmetic circuit that calculates a per-block noise value based on the first image data, and a quantization value setting circuit that sets a per-block quantization value for quantization based on the per-block noise value.", "These and other objects, features, aspects and advantages of the present disclosure will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation U.S. application Ser.", "No.", "15/388,959, filed on Dec. 22, 2016, which is a continuation of U.S. application Ser.", "No.", "14/636,794, filed on Mar.", "3, 2015, which is now U.S. Pat.", "No.", "9,552,628, issued on Jan. 24, 2017, which claims priority from Japanese Patent Application Numbers 2014-049505, 2014-049506, and 2014-049507, each filed on Mar.", "12, 2014.The disclosures of the applications referenced above are incorporated herein by reference herein in their entireties.", "BACKGROUND Technical Field The present disclosure relates to image processors and image processing methods, and more particularly, to denoising devices and denoising methods for removing noise from an input image to generate an output image.", "Related Art Denoising devices in general remove noise from image data of an input image in a spatial region by uniformly applying a spatial filter such as a lowpass filter to remove a high-frequency component on the whole image.", "JPH9-233369A describes a denoising device that applies a median filter around boundaries in an input image while applying a mean filter to other portions.", "SUMMARY In some embodiments, an image processor performs denoising on an input image to generate an output image.", "The image processor includes a transform circuit that transforms first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including multiple frequency components, a quantization circuit that performs quantization on the second image data to generate third image data, an arithmetic circuit that calculates a per-block activity evaluation value based on the first image data, and a quantization value setting circuit that sets a per-block quantization value for quantization based on the per-block activity evaluation value.", "In some embodiments, an image processor performs denoising on an input image to generate an output image.", "The image processor includes a transform circuit that transforms first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including multiple frequency components, a quantization circuit that performs quantization on the second image data to generate third image data, a first arithmetic circuit that calculates a per-block noise value based on the first image data, and a quantization value setting circuit that sets a per-block quantization value for quantization based on the per-block noise value.", "These and other objects, features, aspects and advantages of the present disclosure will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a diagram illustrating a configuration of an image processor according to an embodiment of the present disclosure.", "FIG.", "2 is a flow chart illustrating the sequence of denoising by the image processor.", "FIG.", "3 is a diagram for illustrating setting of a quantization value by a setting circuit.", "FIG.", "4 is a diagram for illustrating setting of a scaling matrix by a setting circuit.", "FIG.", "5 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "6 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "7 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "8 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "9 is a diagram illustrating overlapping.", "FIGS.", "10A to 10C are diagrams for illustrating first setting of the quantization value.", "FIG.", "11 is a diagram for illustrating second setting of the quantization value.", "FIG.", "12 is a diagram illustrating a configuration of the image processor to realize the second setting of the quantization value.", "FIG.", "13 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "14 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "15 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "16 is a diagram illustrating a configuration of the image processor according to a first modification.", "FIG.", "17 is a flow chart illustrating the sequence of denoising by the image processor according to the first modification.", "FIG.", "18 is a diagram illustrating a configuration of the image processor according to a second modification.", "FIG.", "19 is a flow chart illustrating the sequence of denoising by the image processor according to the second modification.", "DETAILED DESCRIPTION In the following detailed description, for purposes of explanation, numerous specific details are set forth in order to provide a thorough understanding of the disclosed embodiments.", "It will be apparent, however, that one or more embodiments may be practiced without these specific details.", "In other instances, well-known structures and devices are schematically illustrated in order to simplify the drawing.", "According to the above-described general denoising devices, applying a spatial filter only once to an input image produces only low denoising effect.", "Applying a spatial filter multiple times would enhance denoising effect, but then there will be a decrease in resolution, which may cause boundaries to blur, making the whole image rather degraded in image quality.", "Furthermore, applying a spatial filter multiple times results in prolonged processing time, and in increased circuit size with the need for a temporal memory for storing intermediate values.", "The present disclosure is directed to obtaining an image processor and an image processing method that realizes high denoising effect while avoiding image degradation and achieves reduction in processing time and circuit size.", "An image processor according to an aspect of the present disclosure is configured to perform denoising on an input image to generate an output image.", "The image processor includes a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, a quantization circuit configured to perform quantization on the second image data to generate third image data, a first arithmetic circuit configured to calculate a per-block noise value based on the first image data, and a first quantization value setting circuit configured to set a first quantization value per input image for quantization based on a noise value of the whole input image.", "In the image processor, the first quantization value setting circuit sets a first quantization value per input image based on a noise value of the whole input image, and the quantization circuit performs quantization on the second image data to generate third image data.", "Quantization using the first quantization value based on the noise value of the whole input image realizes appropriate denoising depending on a noise level of the whole input image.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In this aspect, a first correction value setting circuit may set the first correction value per input image based on the second image data of the whole input image, and a correction circuit may perform correction per frequency component on the third image data to generate fourth image data.", "Correction per frequency component using the first correction value based on the second image data of the whole input image realizes appropriate denoising depending on a noise level per frequency component.", "In this aspect, the first arithmetic circuit may calculate a sum of absolute difference between a pixel value of each pixel and a smoothing value of each pixel, and calculate an average of the sum of absolute difference in a block as per-block noise value.", "Thus the first arithmetic circuit appropriately obtains the per-block noise value.", "In this aspect, the first quantization value setting circuit may increase a first quantization value with increase in a noise value.", "When the noise value of the whole input image is large, a large first quantization value achieves high denoising effect by quantization.", "When the noise value of the whole input image is small, a small first quantization value avoids image degradation due to quantization.", "In this aspect, a second quantization value setting circuit may set the per-block second quantization value for quantization based on the first quantization value and a per-block activity evaluation value.", "The per-block second quantization value based on the first quantization value based on the noise value of the whole input image and the per-block activity evaluation value realizes appropriate denoising on a per block basis depending on the noise level of the whole input image and the attribute of a block.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In this aspect, the second arithmetic circuit may calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "Thus the second arithmetic circuit appropriately obtains the per-block activity evaluation value.", "In this aspect, the second quantization value setting circuit may set the second quantization value to a quantization value larger than the first quantization value for a block having a small activity evaluation value.", "In a flat portion having a small activity evaluation value where noise is noticeable, a large second quantization value achieves high denoising effect by quantization.", "The second quantization value setting circuit may set the second quantization value to a quantization value smaller than the first quantization value for a block having a large activity evaluation value.", "In an edge or texture portion having a large activity evaluation value, a small second quantization value prevents edge or texture portion from blurring due to quantization, and thus improves image quality.", "In this aspect, the second quantization value setting circuit may set the per-block second quantization value for quantization based on the first quantization value and a per-block noise value.", "The per-block second quantization value based on the first quantization value based on the noise value of the whole input image and the per-block noise value realizes appropriate denoising on a per block basis depending on the noise level of the whole input image and the per-block noise level.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In this aspect, the second quantization value setting circuit may increase the second quantization value with increase in a noise value with the first quantization value being an upper limit.", "For a block having a large noise value, a large second quantization value achieves high denoising effect by quantization.", "For a block having a small noise value, a small second quantization value avoids image degradation due to quantization.", "Providing the upper limit at the first quantization value restricts the difference between the maximum and the minimum second quantization value to a certain range, eliminating or reducing “floppiness”, and thus the image quality is improved as a whole.", "In this aspect, the first correction value setting circuit may set the first correction value to a transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in the ideal image including no noise.", "Such first correction value realizes correction to bring the output image close to the ideal image, and thus improves image quality.", "In this aspect, a second correction value setting circuit may set the per-block second correction value for correction based on the first correction value and the per-block activity evaluation value.", "The per-macroblock second correction value based on the first correction value based on the second image data of the whole input image and the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the frequency component value of the whole input image and the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In this aspect, the second correction value setting circuit may hold a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and perform masking on the first correction value using one of the masks corresponding to the activity evaluation value calculated by the second arithmetic circuit to set the second correction value.", "In consequence, the second correction value depending on the per-block activity evaluation value is obtained simply and appropriately from the first correction value.", "In this aspect, the second correction value setting circuit may set the second correction value for a block having a small activity evaluation value to the first correction value for a low-frequency component, while setting the second correction value to substantially zero for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The second correction value setting circuit may set the second correction value for a block having a large activity evaluation value to the first correction value for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value, masking not to cut off any frequency component realizes correction to sharpen the edge or texture portion, and thus improves image quality.", "The second correction value setting circuit may set the second correction value for a block having a medium activity evaluation value to the first correction value for low- and middle-frequency components while setting the second correction value to substantially zero for a high-frequency component.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In this aspect, a determination circuit may determine whether denoising is to be performed on the basis of the noise value of the whole input image and the activity evaluation value of the whole input image.", "Thus since denoising is performed on an input image that truly requires denoising while denoising on an input image that requires no denoising is avoided, power consumption is reduced.", "In this aspect, the determination circuit may divide the noise value of the whole input image by the activity evaluation value of the whole input image to calculate a noise strength.", "Then if the noise strength is lower than a predetermined threshold, denoising may be determined to be unnecessary, while if the noise strength is higher than or equal to the threshold, denoising may be determined to be necessary.", "Such determination by the determination circuit achieves highly accurate identification of an input image that truly requires denoising.", "In this aspect, the transform circuit and the quantization circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, an optimal value obtained from the plurality of overlapping blocks may be output as image data of the portion of the image.", "Output of optimal value (for example, average) obtained from a plurality of blocks for overlapping portion realizes high denoising effect while avoiding image degradation.", "In this aspect, the transform circuit and the quantization circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, output data in processing a current block may be used for input data of the portion of the image in processing a subsequent macroblock.", "Denoising of the same portion of the image is performed practically multiple times in sequentially processing multiple blocks, achieving a shorter processing time, in comparison with in comparison with denoising by obtaining an optimal value from output values of multiple blocks overlap each other.", "In this aspect, denoising may be individually performed on each color component.", "Individual denoising for each color component of the input image achieves optimal denoising effect for each color component.", "In this aspect, integrated denoising on a plurality of color components may be performed.", "Integrated denoising on multiple color components achieves improved accuracy of noise detection.", "Furthermore, since variation in denoising effect among color components is eliminated or reduced, image quality is improved.", "An image processing method according to another aspect of the present disclosure is an image processing method for denoising of an input image to generate an output image.", "The method includes transforming first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, performing quantization on the second image data to generate third image data, calculating a per-block noise value based on the first image data, and setting a first quantization value per input image for quantization based on a noise value of the whole input image.", "In the method, a first quantization value per input image is set on the basis of the noise value of the whole input image, and quantization is performed on second image data to generate third image data.", "Quantization using the first quantization value based on the noise value of the whole input image realizes appropriate denoising depending on a noise level of the whole input image.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "An image processor according to another aspect of the present disclosure is configured to perform denoising on an input image to generate an output image.", "The image processor includes a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, a quantization circuit configured to perform quantization on the second image data to generate third image data, an arithmetic circuit configured to calculate a per-block activity evaluation value based on the first image data, and a quantization value setting circuit configured to set a per-block quantization value for quantization based on the per-block activity evaluation value.", "In the image processor, the quantization value setting circuit sets a per-block quantization value for quantization based on the per-block activity evaluation value.", "The per-block quantization value based on the per-block activity evaluation value realizes appropriate denoising on a per block basis depending on the attribute of a block.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In this aspect, a correction value setting circuit may set a per-block correction value for correction based on the per-block activity evaluation value.", "The per-block correction value based on the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In this aspect, the arithmetic circuit may calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "Thus the arithmetic circuit appropriately obtains the per-block activity evaluation value.", "In this aspect, the quantization value setting circuit may set a quantization value of a block having a small activity evaluation value to a large value.", "In a flat portion having a small activity evaluation value where noise is noticeable, a large quantization value achieves high denoising effect by quantization.", "The quantization value setting circuit may set a quantization value of a block having a large activity evaluation value to a small value.", "In an edge or texture portion having a large activity evaluation value, a small quantization value prevents edge or texture portion from blurring due to quantization, and thus improves image quality.", "The quantization value setting circuit may set a quantization value of a block having a medium activity evaluation value to a medium value.", "In an image portion other than flat, edge, and texture portions, a medium quantization value avoids excessive or insufficient denoising effect on the image portion.", "An image processor according to another aspect of the present disclosure is configured to perform denoising on an input image to generate an output image.", "The image processor includes a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, a quantization circuit configured to perform quantization on the second image data to generate third image data, a first arithmetic circuit configured to calculate a per-block noise value based on the first image data, and a quantization value setting circuit configured to set a per-block quantization value for quantization based on the per-block noise value.", "In the image processor, the quantization value setting circuit sets a per-block quantization value for quantization based on the per-block noise value.", "The per-block quantization value based on the per-block noise value realizes appropriate denoising on a per block basis depending on the noise level per block.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In this aspect, a correction value setting circuit may set a per-block correction value for correction based on the per-block activity evaluation value.", "The per-block correction value based on the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In this aspect, the first arithmetic circuit may calculate a sum of absolute difference between a pixel value of each pixel and a smoothing value of each pixel, and calculate an average of the sum of absolute difference in a block as per-block noise value.", "Thus the first arithmetic circuit appropriately obtains the per-block noise value.", "In this aspect, the quantization value setting circuit may increase the quantization value with increase in a noise value.", "For a block having a large noise value, a large quantization value achieves high denoising effect by quantization.", "For a block having a small noise value, a small quantization value avoids image degradation due to quantization.", "In this aspect, the second arithmetic circuit may calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "Thus the second arithmetic circuit appropriately obtains the per-block activity evaluation value.", "In this aspect, the correction value setting circuit may hold a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and set the correction value to a multiplier for one of the masks corresponding to the activity evaluation value calculate by the second arithmetic circuit.", "In consequence the correction value depending on the per-block activity evaluation value is obtained simply and appropriately.", "In this aspect, the correction value setting circuit may set the correction value for a block having a small activity evaluation value to one time for a low-frequency component and to substantially zero time for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The correction value setting circuit may set the correction value for a block having a large activity evaluation value to one time for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value, masking not to cut off any frequency component realizes correction to sharpen the edge or texture portion, and thus improves image quality.", "The correction value setting circuit may set the correction value for a block having a medium activity evaluation value to one time for low- and middle-frequency components and to substantially zero time for a high-frequency component.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In this aspect, the determination circuit may determine whether denoising is to be performed on the basis of the noise value of the whole input image and the activity evaluation value of the whole input image.", "Thus since denoising is performed on an input image that truly requires denoising while denoising on an input image that requires no denoising is avoided, power consumption is reduced.", "In this aspect, the determination circuit may divide the noise value of the whole input image by the activity evaluation value of the whole input image to calculate a noise strength.", "Then if the noise strength is lower than a predetermined threshold, denoising may be determined to be unnecessary, while if the noise strength is higher than or equal to the threshold, denoising may be determined to be necessary.", "Such determination by the determination circuit achieves highly accurate identification of an input image that truly requires denoising.", "In this aspect, the transform circuit and the quantization circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, an optimal value obtained from the plurality of overlapping blocks may be output as image data of the portion of the image.", "Output of optimal value (for example, average) obtained from a plurality of blocks for overlapping portion realizes high denoising effect while avoiding image degradation.", "In this aspect, the transform circuit and the quantization circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, output data in processing a current block may be used for input data of the portion of the image in processing a subsequent macroblock.", "Denoising of the same portion of the image is performed practically multiple times in sequentially processing multiple blocks, achieving a shorter processing time, in comparison with in comparison with denoising by obtaining an optimal value from output values of multiple blocks overlap each other.", "In this aspect, denoising may be individually performed on each color component.", "Individual denoising for each color component of the input image achieves optimal denoising effect for each color component.", "In this aspect, integrated denoising on a plurality of color components may be performed.", "Integrated denoising on multiple color components achieves improved accuracy of noise detection.", "Furthermore, since variation in denoising effect among color components is eliminated or reduced, image quality is improved.", "An image processing method according to another aspect of the present disclosure is an image processing method for denoising of an input image to generate an output image.", "The method includes transforming first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, performing quantization on the second image data to generate third image data, calculating a per-block activity evaluation value based on the first image data, and setting a per-block quantization value for quantization based on the per-block activity evaluation value.", "In the method, a per-block quantization value for quantization is set on the basis of a per-block activity evaluation value.", "The per-block quantization value based on the per-block activity evaluation value realizes appropriate denoising on a per block basis depending on the attribute of a block.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "An image processing method according to another aspect of the present disclosure is an image processing method for denoising of an input image to generate an output image.", "The method includes transforming first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, performing quantization on the second image data to generate third image data, calculating a per-block noise value based on the first image data, and setting a per-block quantization value for quantization based on the per-block noise value.", "In the method, a per-block quantization value for quantization may be set on the basis of the per-block noise value.", "The per-block quantization value based on the per-block noise value realizes appropriate denoising on a per block basis depending on the noise level per block.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "An image processor according to another aspect of the present disclosure is configured to perform denoising on an input image to output an output image.", "The image processor includes a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, a quantization circuit configured to perform quantization on the second image data to generate third image data, a correction circuit configured to perform correction per frequency component on the third image data to generate fourth image data, and a first correction value setting circuit configured to set a first correction value per input image for correction based on the second image data of the whole input image.", "The first correction value setting circuit is configured to set the first correction value to a transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in an ideal image including no noise.", "In the image processor, the first correction value setting circuit may set the first correction value per input image based on the second image data of the whole input image, and the correction circuit may perform correction per frequency component on the third image data to generate fourth image data.", "Correction per frequency component using the first correction value based on the second image data of the whole input image realizes appropriate denoising depending on a noise level per frequency component.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "The first correction value setting circuit may set the first correction value to the transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in the ideal image including no noise.", "Such first correction value realizes correction to bring the output image close to the ideal image, and thus improves image quality.", "In this aspect, the second correction value setting circuit may set the per-block second correction value for correction based on the first correction value and the per-block activity evaluation value.", "The per-macroblock second correction value based on the first correction value based on the second image data of the whole input image and the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the frequency component value of the whole input image and the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In this aspect, the second correction value setting circuit may hold a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and perform masking on the first correction value using one of the masks corresponding to the activity evaluation value calculated by the arithmetic circuit to set the second correction value.", "In consequence, the second correction value depending on the per-block activity evaluation value is obtained simply and appropriately from the first correction value.", "In this aspect, the second correction value setting circuit may set the second correction value for a block having a small activity evaluation value to the first correction value for a low-frequency component, while setting the second correction value to substantially zero for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The second correction value setting circuit may set the second correction value for a block having a large activity evaluation value to the first correction value for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value, masking not to cut off any frequency component realizes correction to sharpen the edge or texture portion, and thus improves image quality.", "The second correction value setting circuit may set the second correction value for a block having a medium activity evaluation value to the first correction value for low- and middle-frequency components while setting the second correction value to substantially zero for a high-frequency component.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In this aspect, the arithmetic circuit may calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "Thus the arithmetic circuit appropriately obtains the per-block activity evaluation value.", "An image processor according to another aspect of the present disclosure is configured to perform denoising on an input image to generate an output image.", "The image processor includes a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, a quantization circuit configured to perform quantization on the second image data to generate third image data, a correction circuit configured to perform correction per frequency component on the third image data to generate fourth image data, an arithmetic circuit configured to calculate a per-block activity evaluation value based on the first image data, and a correction value setting circuit configured to set a per-block correction value for correction based on the per-block activity evaluation value.", "The correction value setting circuit is configured to hold a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and set the correction value to a multiplier for one of the masks corresponding to the activity evaluation value calculated by the arithmetic circuit.", "In this aspect, the correction value setting circuit sets a per-block correction value for correction based on the per-block activity evaluation value.", "The per-block correction value based on the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "The correction value setting circuit holds a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and sets the correction value to a multiplier for one of the masks corresponding to the activity evaluation value calculated by the arithmetic circuit.", "In consequence the correction value depending on the per-block activity evaluation value is obtained simply and appropriately.", "In this aspect, the correction value setting circuit may set the correction value for a block having a small activity evaluation value to one time for a low-frequency component and to substantially zero time for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The correction value setting circuit may set the correction value for a block having a large activity evaluation value to one time for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value, masking not to cut off any frequency component realizes correction to sharpen the edge or texture portion, and thus improves image quality.", "The correction value setting circuit may set the correction value for a block having a medium activity evaluation value to one time for low- and middle-frequency components and to substantially zero time for a high-frequency component.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In this aspect, the arithmetic circuit may calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "Thus the arithmetic circuit appropriately obtains per-block activity evaluation value.", "In this aspect, the determination circuit may determine whether denoising is to be performed on the basis of the noise value of the whole input image and the activity evaluation value of the whole input image.", "Thus since denoising is performed on an input image that truly requires denoising while denoising on an input image that requires no denoising is avoided, power consumption is reduced.", "In this aspect, the determination circuit may divide the noise value of the whole input image by the activity evaluation value of the whole input image to calculate a noise strength.", "Then if the noise strength is lower than a predetermined threshold, denoising may be determined to be unnecessary, while if the noise strength is higher than or equal to the threshold, denoising may be determined to be necessary.", "Such determination by the determination circuit achieves highly accurate identification of an input image that truly requires denoising.", "In this aspect, the transform circuit, the quantization circuit, and the correction circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, an optimal value obtained from the plurality of overlapping blocks may be output as image data of the portion of the image.", "Output of optimal value (for example, average) obtained from a plurality of blocks for overlapping portion realizes high denoising effect while avoiding image degradation.", "In this aspect, the transform circuit, the quantization circuit, and the correction circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, output data in processing a current block may be used for input data of the portion of the image in processing a subsequent macroblock.", "Denoising of the same portion of the image is performed practically multiple times in sequentially processing multiple blocks, achieving a shorter processing time, in comparison with in comparison with denoising by obtaining an optimal value from output values of multiple blocks overlap each other.", "In this aspect, denoising may be individually performed on each color component.", "Individual denoising for each color component of the input image achieves optimal denoising effect for each color component.", "In this aspect, integrated denoising on a plurality of color components may be performed.", "Integrated denoising on multiple color components achieves improved accuracy of noise detection.", "Furthermore, since variation in denoising effect among color components is eliminated or reduced, image quality is improved.", "An image processing method according to another aspect of the present disclosure is an image processing method for denoising of an input image to output an output image.", "The method includes transforming first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, performing quantization on the second image data to generate third image data, performing correction per frequency component on the third image data to generate fourth image data, and setting a first correction value per input image for correction based on the second image data of the whole input image.", "The setting of the first correction value includes setting the first correction value to a transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in an ideal image including no noise.", "In the image processing method, the setting of the first correction value includes setting the first correction value per input image based on the second image data of the whole input image, and the performing correction on the third image data includes performing correction per frequency component on the third image data to generate fourth image data.", "Correction per frequency component using the first correction value based on the second image data of the whole input image realizes appropriate denoising depending on a noise level per frequency component.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "The setting of the first correction value further includes setting the first correction value to a transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in an ideal image including no noise.", "Such first correction value realizes correction to bring the output image close to the ideal image, and thus improves image quality.", "An image processing method according to another aspect of the present disclosure is an image processing method for denoising of an input image to generate an output image.", "The method includes transforming first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, performing quantization on the second image data to generate third image data, performing correction per frequency component on the third image data to generate fourth image data, calculating a per-block activity evaluation value based on the first image data, and setting a per-block correction value for correction based on the per-block activity evaluation value.", "The setting of the correction value includes holding a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and setting the correction value to a multiplier for one of the masks corresponding to the activity evaluation value calculate in the calculating of the per-block activity evaluation value.", "The image processing method includes setting a per-block correction value for correction based on the per-block activity evaluation value.", "The per-block correction value based on the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "The method includes holding a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and setting the correction value to a multiplier for one of the masks corresponding to the activity evaluation value calculate in the calculating of the per-block activity evaluation value.", "In consequence the correction value depending on the per-block activity evaluation value is obtained simply and appropriately.", "Some embodiments of the present disclosure provide an image processor and an image processing method that realize high denoising effect while avoiding image degradation and achieve reduction in processing time and circuit size.", "DESCRIPTION OF EMBODIMENTS Embodiments of the present disclosure are described in detail below referring to the drawings.", "It should be noted that identical reference numerals throughout the drawings indicate identical or equivalent elements.", "FIG.", "1 is a diagram illustrating a configuration of an image processor 1 according to an embodiment of the present disclosure.", "The image processor 1 receives an input image including R, Gr, Gb, and B color components in Bayer array sorted by color components.", "The image processor 1 performs denoising individually on the input image of each color component, so as to generate and output an output image.", "Color components of the input image are not limited to R, Gr, Gb, and B but may be R, G, and, B, Y, U, and V, or the like.", "FIG.", "1 illustrates a relation of connection of the image processor 1 including a transform circuit 11, a quantization circuit 12, a correction circuit 13, an inverse quantization circuit 14, an inverse transform circuit 15, a selector 16, a setting circuit 17, a filter circuit 18, arithmetic circuits 19 and 20, and setting circuits 21 to 24.The transform circuit 11 transforms image data D1 of a spatial region extracted from an input image in a unit of a predetermined block (in this example, macroblock by macroblock, each macroblock having 8 rows×8 columns) into image data D2 of a frequency region including multiple frequency components by DCT transform.", "The block size is not limited to 8 rows×8 columns but may be, for example, 16 rows×16 columns.", "With a bigger block size, the circuit size increases, but the image quality is improved with finer control over frequency components.", "The quantization circuit 12 performs quantization on image data D2 to generate image data D3.The correction circuit 13 performs correction per frequency component on the image data D3 to generate image data D4.The inverse quantization circuit 14 performs inverse quantization on the image data D4 to generate image data D5.The inverse transform circuit 15 transforms the image data D5 of a frequency region into image data D6 of a spatial region by inverse DCT transform.", "The selector 16 selects and outputs the image data D1 or the image data D6.A CPU 2 determines whether denoising is to be performed, on the basis of a noise value of the whole input image NOISE(PIC) and an activity evaluation value of the whole input image ACT(PIC).", "A result of the determination is configured in the setting circuit 17.The setting circuit 17 causes the selector 16 to select the image data D6 if denoising is necessary, while causing the selector 16 to select the image data D1 if denoising is unnecessary.", "The filter circuit 18 is an arbitrary smoothing filter (in this example, the Gaussian filter having 3 rows×3 columns), which calculates a weighted mean GAUS (i, j) of each pixel, on the basis of a pixel value of each pixel and pixel values of multiple adjacent pixels (eight pixels for 3 rows×3 columns).", "The arithmetic circuit 19 calculates a per-macroblock noise value NOISE(MB), on the basis of the image data D1 and the image data D1 processed by the filter circuit 18 with a weighted mean.", "The arithmetic circuit 19 also calculates an average of noise values NOISE(MB) of all macroblocks in the input image which serves as a noise value NOISE(PIC).", "The noise value NOISE(PIC) may be calculated by inputting a sum of the noise values NOISE(MB) of all macroblocks in the input image from the arithmetic circuit 19 to the CPU 2 and dividing the sum by the number of macroblocks in the CPU 2.The arithmetic circuit 20 calculates a per-macroblock activity evaluation value ACT(MB), on the basis of the image data D1 processed by the filter circuit 18 with a weighted mean.", "The arithmetic circuit 20 also calculates an average of activity evaluation values ACT(MB) of all macroblocks in the input image which serves as an activity evaluation value ACT(PIC).", "The activity evaluation value ACT(PIC) may be calculated by inputting a sum of the activity evaluation values ACT(MB) of all macroblocks in the input image from the arithmetic circuit 20 to the CPU 2 and dividing the sum by the number of macroblocks in the CPU 2.The setting circuit 21 sets a quantization value QP(PIC) per input image for quantization by the quantization circuit 12, on the basis of the noise value NOISE(PIC).", "The setting circuit 22 sets a per-macroblock quantization value QP(MB) for quantization by the quantization circuit 12, on the basis of an internal parameter of the image processor 1 (for example, the quantization value QP(PIC), the activity evaluation value ACT(MB), and the noise value NOISE(MB)).", "The setting circuit 23 sets a scaling matrix SM(PIC) that contains a correction value per input image for correction by the correction circuit 13, on the basis of the image data D2 of the whole input image.", "The setting circuit 24 sets a scaling matrix SM(MB) that contains a per-macroblock correction value for correction by the correction circuit 13, on the basis of an internal parameter of the image processor 1 (for example, the scaling matrix SM(PIC), the activity evaluation value ACT(MB), the noise value NOISE(PIC), and the activity evaluation value ACT(PIC)).", "FIG.", "2 is a flow chart illustrating the sequence of denoising by the image processor 1.Firstly in Step P101, the setting circuit 17 sets the selector 16, in accordance with determination by the CPU 2 as to whether denoising is to be performed.", "If denoising is unnecessary, processing ends.", "If denoising is necessary, in Step P102, the setting circuit 21 sets the quantization value QP(PIC).", "In Step P103, the setting circuit 23 set the scaling matrix SM(PIC).", "In Steps P104 to P110, per-macroblock denoising is repeated for all macroblocks in the input image.", "In Step P104, the arithmetic circuit 20 calculates the activity evaluation value ACT(MB).", "In Step P105, the setting circuit 22 sets the quantization value QP(MB).", "The setting circuit 24 also sets the scaling matrix SM(MB).", "In Step P106, the transform circuit 11 transforms the image data D1 into the image data D2.In Step P107, the quantization circuit 12 performs quantization using the quantization value QP(MB) on the image data D2 to generate the image data D3.In Step P108, the correction circuit 13 performs correction using the scaling matrix SM(MB) on the image data D3 to generate the image data D4.In Step P109, the inverse quantization circuit 14 performs inverse quantization on the image data D4 to generate the image data D5.In Step P110, the inverse transform circuit 15 transforms the image data D5 into the image data D6 by inverse DCT transform.", "Processing ends with completion of per-macroblock denoising for all macroblocks in the input image.", "Description is given of details of processing by each processing unit illustrated in FIG.", "1.<Calculation of GAUS (i, j)> The filter circuit 18 calculates a weighted mean GAUS (i, j) of each pixel given by Equation 1, where CURR (i, j) is a pixel value of each pixel in a macroblock: Equation   1 GAUS  ( i , j ) = CURR  ( i , j ) * [ 1 2 1 2 4 2 1 2 1 ] // 16 ( 1 ) <Calculation of NOISE(MB)> The arithmetic circuit 19 calculates a sum of absolute difference between the pixel value CURR (i, j) of each pixel and the weighted mean GAUS (i, j) of each pixel given by Equation 2.Then the arithmetic circuit 19 calculates an average of the sum of absolute difference in the macroblock given by Equation 3, which serves as the per-macroblock noise value NOISE(MB).", "Equation   2 diff_  8 × 8  blk = ∑ j - 0 7  ∑ i - 0 7   CURR  ( i , j ) - GAUS  ( i , j )  ( 2 ) Equation   3 NOISE  ( MB ) = diff_  8 × 8  blk // 64 ( 3 ) <Setting of QP(PIC)> FIG.", "3 is a diagram for illustrating setting of the quantization value QP(PIC) by the setting circuit 21.The arithmetic circuit 19 calculates an average of noise values NOISE(MB) of all macroblocks in the input image, which serves as the noise value NOISE(PIC).", "The setting circuit 21 holds a look-up table containing an optimal quantization value QP(PIC) for each noise value NOISE(PIC).", "The setting circuit 21 normalizes the look-up table in the distribution range of the weighted means GAUS (i, j) in the histogram of the weighted means GAUS (i, j) and the number of pixels.", "Then the setting circuit 21 uses the normalized look-up table to set the quantization value QP(PIC) of the input image to the quantization value corresponding to the noise value NOISE(PIC).", "As illustrated in FIG.", "3, the setting circuit 21 increases the quantization value QP(PIC) with increase in the noise value NOISE(PIC).", "<Setting of SM(PIC)> FIGS.", "4 to 8 are diagrams for illustrating setting of the scaling matrix SM(PIC) by the setting circuit 23.The setting circuit 23 firstly obtains the quantization value QP(PIC) in the same method as the setting circuit 21.The setting circuit 23 then acquires image data D3 on which DCT transform and quantization with the quantization value QP(PIC) have been performed, for all macroblocks in the input image.", "Absolute values of frequency component values of all macroblocks are accumulated for each frequency component in the image data D3 to obtain a sum of absolute difference K1 of each frequency component value of the input image.", "An example of the sum of absolute difference K1 is illustrated in FIG.", "4.The frequency component value at the top-left corner as oriented in the figure corresponds to a DC component, and the frequency component value at the bottom-right corner corresponds to a component having the highest frequency.", "The setting circuit 23 acquires the image data D2 on which DCT transform has been performed, for all macroblocks in an ideal image prepared in advance.", "The ideal image is an image that includes no noise in which a subject is shot in the same composition as the input image.", "For example, when the image processor 1 is used for a security camera, the input image is an image with much noise shot under low illumination such as at nighttime, while the ideal image is an image with little noise shot under high illumination such as at daytime.", "The setting circuit 23 accumulates absolute values of frequency component values of all macroblocks for each frequency component in the image data D2 to obtain a sum of absolute difference K2 of each frequency component value of the ideal image.", "An example of the sum of absolute difference K2 is illustrated in FIG.", "5.The setting circuit 23 then normalizes each frequency component value of the sum of absolute difference K2 to have the frequency component value of the DC component of the sum of absolute difference K2 equal to that of the sum of absolute difference K1, so as to produce a normalized sum of absolute difference K3.An example of the sum of absolute difference K3 is illustrated in FIG.", "6.The setting circuit 23 then calculates a transform value (multiplier) for transforming the sum of absolute difference K1 of each frequency component value so that each frequency component value of the sum of absolute difference K1 equals to (or approaches) each frequency component value of the sum of absolute difference K3.In other words, the setting circuit 23 sets the correction value to the transform value for transforming each frequency component value in the input image so that a ratio of each frequency component value to the DC component in the input image equals to that in the ideal image.", "The setting circuit 23 then employs predetermined coefficients for substituting for the multipliers of the frequency components to produce the scaling matrix SM(PIC).", "An example of the scaling matrix SM(PIC) is illustrated in FIG.", "7.An example of a correspondence between coefficients and multipliers is illustrated in FIG.", "8.In the scaling matrix SM(PIC), the coefficient “16” corresponds to the multiplier “1” (that is, passed through) and the coefficient “255” corresponds to the smallest multiplier being substantially zero (that is, cut off).", "If the ideal image is not available, the coefficient “16” is employed for all frequency components, so as to produce the scaling matrix SM(PIC) that causes the correction circuit 13 to practically serve as a through filter.", "Alternatively, the scaling matrix SM(PIC) for general-purpose use may be prepared in advance, and such scaling matrix SM(PIC) may be used if the ideal image is not available.", "<Overlapping> In the image processor 1, overlapping of macroblocks is performed on a macroblock having 8 rows×8 columns with a subsequent macroblock extracted from a position shifted by four pixels serving as the image data D1.The number of pixels for the shift is not limited to four, but may be an arbitrary number.", "With a shift by fewer pixels, processing time elongates, but the image quality is improved.", "FIG.", "9 is a diagram illustrating overlapping.", "FIG.", "9 illustrates the input image having 16 rows×16 columns to facilitate the description.", "Firstly a macroblock MB1 is extracted, starting from the top-left corner, as oriented in the figure, of the input image.", "Then a macroblock MB2 is extracted, from the position shifted row-wise by four pixels from the macroblock MB1.Then a macroblock MB3 is extracted from the position shifted row-wise by four pixels from the macroblock MB2.Then a macroblock MB4 is extracted from the position shifted column-wise by four pixels from the macroblock MB1.From then on, macroblocks MB5 to MB9 are similarly extracted in sequence.", "Thus the transform circuit 11, the quantization circuit 12, the correction circuit 13, the inverse quantization circuit 14, and the inverse transform circuit 15 sequentially process partially-overlapping multiple macroblocks MB1 to MB9 extracted from the input image.", "For a portion of the output image where multiple macroblocks overlap each other, an optimal value (in this example, an average) obtained from the overlapping multiple macroblocks is output as image data of this portion.", "For example, four macroblocks MB1, MB2, MB4, and MB5 overlap each other in the portion having 4 rows×4 columns of the image colored gray in FIG.", "9, and thus image data D6 is obtained for each of these four macroblocks.", "Thus the image data D6 of this portion of these four macroblocks are added together, and the value obtained by the addition is divided by four, which is the number of macroblocks overlapping each other, so that an average of the image data D6 of the multiple macroblocks overlapping each other is calculated.", "Then the average is output from the image processor 1 as the image data D6 of this portion of the image.", "As a first modification of overlapping, the above optimal value may be, instead of the above average, an output value (image data D6) of a macroblock having the smallest noise value NOISE(MB) among multiple macroblocks overlapping each other.", "As a second modification of overlapping, for a portion of the image where multiple macroblocks overlap each other, an output value of this portion of the image obtained in processing a current macroblock may be used for an input value of this portion of the image for processing a subsequent macroblock.", "For example, regarding the portion having 4 rows×4 columns of the image colored gray in FIG.", "9, an output value (image data D6) obtained in processing the macroblock MB1 is used for an input value (image data D1) for processing the macroblock MB2, an output value obtained in processing the macroblock MB2 is used for an input value for processing the macroblock MB4, and an output value obtained in processing the macroblock MB4 is used for an input value for processing the macroblock MB5.In this method, denoising of the same portion of the image is performed practically multiple times in sequentially processing multiple macroblocks, achieving a shorter processing time, in comparison with denoising by obtaining an average of multiple output values.", "<Calculation of ACT(MB)> The arithmetic circuit 20 calculates an average AVE_BLK of weighted means in a macroblock given by Equation 4.Then the arithmetic circuit 20 calculates a sum of absolute difference between the weighted mean GAUS (i, j) of each pixel and the average AVE_BLK in the macroblock given by Equation 5.Then the arithmetic circuit 20 calculates an average of the sum of absolute difference in the macroblock given by Equation 6, which serves as the per-macroblock activity evaluation value ACT(MB).", "Equation   4 AVE_BLK = ( ∑ j = 0 7  ∑ i = 0 7  GAUS  ( i , j ) ) // 64 ( 4 ) Equation    5 vari_  8 × 8  blk = ∑ j = 0 7  ∑ i = 0 7   GAUS  ( i , j ) - AVE_BLK  ( 5 ) Equation   6 ACT  ( MB ) = vari_  8 × 8  blk // 64 ( 6 ) <First Setting of QP(MB)> FIGS.", "10A to 10C are diagrams for illustrating first setting of the quantization value QP(MB) by the setting circuit 22.The setting circuit 22 sets the quantization value QP(MB) on the basis of the quantization value QP(PIC) and the activity evaluation value ACT(MB).", "The setting circuit 22 holds a look-up table containing an optimal quantization value QP(MB) for each activity evaluation value ACT(MB).", "As illustrated in FIGS.", "10A and 10B, the setting circuit 22 normalizes the look-up table in a distribution range of the activity evaluation value ACT(MB), in the histogram of the activity evaluation value ACT(MB) and the number of macroblocks.", "As illustrated in FIG.", "10B, according to the look-up table, the quantization value QP(MB) decreases with increase in the activity evaluation value ACT(MB).", "As illustrated in FIG.", "10C, the setting circuit 22 sets an upper-limit quantization value QPH to a value larger than the quantization value QP(PIC) by ΔH and a lower-limit quantization value QPL to a value smaller than the quantization value QP(PIC) by ΔL.", "Then the setting circuit 22 sets the quantization value QP(MB) of a macroblock whose quantization value QP(MB) in FIG.", "10B exceeds the upper-limit quantization value QPH, which is a macroblock having a small activity evaluation value ACT(MB) (smaller than value A1), to the upper-limit quantization value QPH.", "The quantization value QP(MB) of a macroblock whose quantization value QP(MB) in FIG.", "10B is smaller than or equal to the upper-limit quantization value QPH and larger than or equal to the lower-limit quantization value QPL, which is a macroblock having a medium activity evaluation value ACT(MB) (larger than or equal to value A1 and smaller than or equal to value A2), is set to the quantization value QP(MB) in FIG.", "10B without change.", "The quantization value QP(MB) of a macroblock whose quantization value QP(MB) in FIG.", "10B is smaller than the lower-limit quantization value QPL, which is a macroblock having a large activity evaluation value ACT(MB) (larger than value A2), is set to the lower-limit quantization value QPL.", "<Second Setting of QP(MB)> FIG.", "11 is a diagram for illustrating second setting of the quantization value QP(MB) by the setting circuit 22.The setting circuit 22 sets the quantization value QP(MB) on the basis of the quantization value QP(PIC) and the noise value NOISE(MB).", "The setting circuit 22 calculates the quantization value QP(MB) given by Equation 7 on the basis of the noise value NOISE(MB).", "As illustrated in FIG.", "11, the setting circuit 22 increases the quantization value QP(MB) with increase in the noise value NOISE(MB).", "Equation 7 QP(MB)=gain*(6*log 2(NOISE(MB)))+offset (7) The setting circuit 22 uses the quantization value QP(PIC) for the upper limit of the quantization value QP(MB), so that if the quantization value QP(MB) given by Equation 7 exceeds the quantization value QP(PIC), the quantization value QP(MB) is set to the quantization value QP(PIC).", "FIG.", "12 is a diagram illustrating a configuration of the image processor 1 to realize the second setting of the quantization value QP(MB).", "The noise value NOISE(MB) is input from the arithmetic circuit 19 to the setting circuit 22.The quantization value QP(PIC) can be calculated by replacing the noise value NOISE(MB) in Equation 7 by noise value NOISE(PIC).", "Thus the setting circuit 21 may set the quantization value QP(PIC) using an operation in accordance with Equation 7, instead of the look-up table illustrated in FIG.", "3.<Setting of SM(MB)> FIGS.", "13 to 15 are diagrams for illustrating setting of the scaling matrix SM(MB) by the setting circuit 24.The setting circuit 24 sets the scaling matrix SM(MB) on the basis of the scaling matrix SM(PIC) and the activity evaluation value ACT(MB).", "Referring to FIG.", "13, the setting circuit 24 performs masking on the scaling matrix SM(PIC) with a low-level mask ML for a macroblock having a small activity evaluation value ACT(MB) (smaller than value A1).", "The mask ML has a mask value for passing through a low-frequency component with a multiplier “1” and cutting off middle- and high-frequency components with a multiplier being substantially zero.", "Thus the correction value of the scaling matrix SM(MB) for low-frequency components is set to that of the scaling matrix SM(PIC) and the correction value of the scaling matrix SM(MB) for middle- and high-frequency components is set to substantially zero.", "Referring to FIG.", "14, the setting circuit 24 performs masking on the scaling matrix SM(PIC) with a middle-level mask MM for a macroblock having a medium activity evaluation value ACT(MB) (larger than or equal to value A1 and smaller than or equal to value A2).", "The mask MM has a masking value for passing through low- and middle-frequency components with a multiplier “1” and cutting off a high-frequency component with a multiplier being substantially zero.", "Thus the correction value of the scaling matrix SM(MB) for low- and middle-frequency components is set to that of the scaling matrix SM(PIC) and the correction value of the scaling matrix SM(MB) for a high-frequency component is set to substantially zero.", "Referring to FIG.", "15, the setting circuit 24 performs masking on the scaling matrix SM(PIC) with a high-level mask MH for a macroblock having a large activity evaluation value ACT(MB) (larger than value A2).", "The mask MH has a mask value for passing through low-, middle-, and high-frequency components with a multiplier “1”.", "Thus the correction value of the scaling matrix SM(MB) for all low-, middle-, and high-frequency components is set to that of the scaling matrix SM(PIC).", "Masking of three scales with three masks ML, MM, and MH is described above as an example, while masking of four or more scales (for example, eight scales) may be possible by preparing four or more masks depending on a variable such as the activity evaluation value ACT(MB).", "Furthermore, the multiplier of each of the masks ML, MM, and MH illustrated in FIGS.", "13 to 15 is only a non-limiting example.", "The multiplier of each of the masks ML, MM, and MH can be set to an arbitrary value depending on, for example, an amount of noise.", "<Determination Whether Denoising is to be Performed> The arithmetic circuit 19 calculates an average of the noise values NOISE(MB) of all macroblocks in the input image which serves as the noise value NOISE(PIC), and inputs the noise value NOISE(PIC) to the CPU 2.The arithmetic circuit 20 also calculates an average of the activity evaluation values ACT(MB) of all macroblocks in the input image which serves as the activity evaluation value ACT(PIC), and inputs the activity evaluation value ACT(PIC) to the CPU 2.The CPU 2 determines whether denoising is to be performed for each input image, on the basis of the noise value NOISE(PIC) of the whole input image and the activity evaluation value ACT(PIC) of the whole input image.", "The CPU 2 divides the noise value NOISE(PIC) by the activity evaluation value ACT(PIC) (NOISE(PIC)/ACT(PIC)) to calculate a noise strength.", "Then if the noise strength is lower than a predetermined threshold (for example, “1”), denoising is determined to be unnecessary, while if the noise strength is higher than or equal to the threshold, denoising is determined to be necessary.", "Thus controlling ON/OFF of denoising in a unit of a picture achieves reduction in power consumption.", "If delay time in processing is not a problem, for example, when the input image is a still picture, the CPU 2 can calculate the noise value NOISE(PIC) and the activity evaluation value ACT(PIC) of the input image itself, and on the basis of them, determine whether denoising is to be performed.", "In contrast, if delay time in processing is a problem, for example, when the input image is a moving picture, the CPU 2 can determine whether denoising is to be performed on a current input image, on the basis of the noise value NOISE(PIC) and the activity evaluation value ACT(PIC) of an immediately preceding input image (i.e., image of one frame before).", "<First Modification> In the above embodiment, the quantization value is set on the basis of both the quantization value QP(PIC) and the quantization value QP(MB), and the correction value is set on the basis of both the scaling matrix SM(PIC) and the scaling matrix SM(MB), but the quantization value may be set on the basis of the quantization value QP(PIC) only, and the correction value may be set on the basis of the scaling matrix SM(PIC) only.", "FIG.", "16 is a diagram illustrating a configuration of the image processor 1 according to the present modification.", "The setting circuits 22 and 24 are omitted from the configuration illustrated in FIG.", "1.FIG.", "17 is a flow chart illustrating the sequence of denoising by the image processor 1 according to the present modification.", "Firstly in Step P201, the setting circuit sets the selector 16, in accordance with determination by the CPU 2 as to whether denoising is to be performed.", "If denoising is unnecessary, processing ends.", "If denoising is necessary, in Step P202, the setting circuit 21 sets the quantization value QP(PIC).", "In Step P203, the setting circuit 23 sets the scaling matrix SM(PIC).", "In Steps P204 to P208, per-macroblock denoising is repeated for all macroblocks in the input image.", "In Step P204, the transform circuit 11 transforms the image data D into the image data D2.In Step P205, the quantization circuit 12 performs quantization using the quantization value QP(PIC) on the image data D2 to generate the image data D3.In Step P206, the correction circuit 13 performs correction using the scaling matrix SM(PIC) on the image data D3 to generate the image data D4.In Step P207, the inverse quantization circuit 14 performs inverse quantization on the image data D4 to generate the image data D5.In Step P208, the inverse transform circuit 15 transforms the image data D5 into the image data D6 by inverse DCT transform.", "Processing ends with completion of per-macroblock denoising for all macroblocks in the input image.", "<Second Modification> In the above embodiment, the quantization value is set on the basis of both the quantization value QP(PIC) and the quantization value QP(MB), and the correction value is set on the basis of both the scaling matrix SM(PIC) and the scaling matrix SM(MB), but the quantization value may be set on the basis of the quantization value QP(MB) only, and the correction value may be set on the basis of the scaling matrix SM(MB) only.", "FIG.", "18 is a diagram illustrating a configuration of the image processor 1 according to the present modification.", "The setting circuits 21 and 23 are omitted from the configuration illustrated in FIG.", "1.FIG.", "19 is a flow chart illustrating the sequence of denoising by the image processor 1 according to the present modification.", "Firstly in Step P301, the setting circuit sets the selector 16, in accordance with determination by the CPU 2 as to whether denoising is to be performed.", "If denoising is unnecessary, processing ends.", "In Steps P302 to P308, per-macroblock denoising is repeated for all macroblocks in the input image.", "In Step P302, the arithmetic circuit 20 calculates the activity evaluation value ACT(MB).", "In Step P303, the setting circuit 22 sets the quantization value QP(MB).", "The setting circuit 24 also sets the scaling matrix SM(MB).", "In the present modification, the setting circuit 24 uses the low-level mask ML (FIG.", "13) as the scaling matrix SM(MB) for a macroblock having a small activity evaluation value ACT(MB)(smaller than value A1).", "For a macroblock having a medium activity evaluation value ACT(MB) (larger than or equal to value A1 and smaller than or equal to value A2), the setting circuit 24 uses the middle-level mask MM (FIG.", "14) as the scaling matrix SM(MB).", "For a macroblock having a large activity evaluation value ACT(MB) (larger than value A2), the setting circuit 24 uses the high-level mask MH (FIG.", "15) as the scaling matrix SM (MB).", "In Step P304, the transform circuit 11 transforms the image data D1 into the image data D2.In Step P305, the quantization circuit 12 performs quantization using the quantization value QP(MB) on the image data D2 to generate the image data D3.In Step P306, the correction circuit 13 performs correction on the scaling matrix SM(MB) on the image data D3 to generate the image data D4.In Step P307, the inverse quantization circuit 14 performs inverse quantization on the image data D4 to generate the image data D5.In Step P308, the inverse transform circuit 15 transforms the image data D5 into the image data D6 by inverse DCT transform.", "Processing ends with completion of per-macroblock denoising for all macroblocks in the input image.", "<Third Modification> In the above embodiment, the denoising is individually performed on each color component of the input image, but integrated denoising on all (or part of multiple) color components may be performed.", "The arithmetic circuit 19 averages the noise values NOISE(PIC) of each color component to calculate an average noise value NOISE(PIC) of all color components.", "The arithmetic circuit 20 averages the activity evaluation values ACT(PIC) of each color component to calculate an average activity evaluation value ACT(PIC) of all color components.", "The arithmetic circuit 19 averages the noise values NOISE(MB) of each color component to calculate an average noise value NOISE(MB) of all color components.", "The arithmetic circuit 20 averages the activity evaluation values ACT(MB) of each color component to calculate an average activity evaluation value ACT(MB) of all color components.", "These average noise values NOISE(PIC) and NOISE(MB) and average activity evaluation values ACT(PIC) and ACT(MB) are used to set common quantization values QP(PIC) and QP(MB) and common scaling matrices SM(PIC) and SM(MB) common to all color components to perform integrated denoising.", "Thus integrated denoising performed on all (or part of multiple) color component achieves improved accuracy of noise detection.", "Furthermore, since variation in denoising effect among color components is eliminated or reduced, image quality is improved.", "On the other hand, individual denoising for each color component of the input image as in the above embodiment achieves optimal denoising effect for each color component.", "If the amount of noise significantly differs among color components, such as when the amount of noise of only some of color components is outstanding, the method according to above embodiment is effective.", "<Fourth Modification> In the above embodiment, the image processor 1 is configured as hardware such as a dedicated LSI.", "Instead of this configuration, a function similar to that of the image processor 1 can be realized by software processing by the CPU 2 that reads and executes a program stored in a recording medium such as a ROM.", "<Recapitulation> In the image processor 1 according to the above embodiment and first modification, the setting circuit 21 (first quantization value setting circuit) sets quantization value QP(PIC) (first quantization value) per input image on the basis of the noise value NOISE(PIC) of the whole input image, and the quantization circuit 12 performs quantization on the image data D2 (second image data) to generate the image data D3 (third image data).", "Quantization using the quantization value QP(PIC) based on the noise value NOISE(PIC) of the whole input image realizes appropriate denoising depending on a noise level of the whole input image.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In the image processor 1 according to the above embodiment and first modification, the setting circuit 23 (first correction value setting circuit) sets the scaling matrix SM(PIC) (first correction value) per input image on the basis of the image data D2 of the whole input image, and the correction circuit 13 performs correction per frequency component on the image data D3 to generate the image data D4 (fourth image data).", "Correction on a per frequency component basis using the scaling matrix SM(PIC) based on the image data D2 of the whole input image realizes appropriate denoising depending on a noise level per frequency component.", "In the image processor 1 according to the above embodiment, the arithmetic circuit 19 (first arithmetic circuit) calculates a sum of absolute difference between a pixel value of each pixel and a smoothing value (weighted mean in the above example) of each pixel, and calculates an average of the sum of absolute difference in a macroblock to obtain a per-macroblock noise value NOISE(MB).", "Thus the arithmetic circuit 19 appropriately obtains the noise value NOISE(MB) on a per macroblock basis.", "In the image processor 1 according to the above embodiment, the setting circuit 21 increases the quantization value QP(PIC) with increase in a noise value.", "When the noise value NOISE(PIC) of the whole input image is large, a large quantization value QP(PIC) achieves high denoising effect by quantization.", "When the noise value NOISE(PIC) of the whole input image is small, a small quantization value QP(PIC) avoids image degradation due to quantization.", "In the image processor 1 according to the above embodiment, the setting circuit 22 (second quantization value setting circuit) sets the per-macroblock quantization value QP(MB) (second quantization value) for quantization, on the basis of the quantization value QP(PIC) and the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock quantization value QP(MB) based on the quantization value QP(PIC) based on the noise value NOISE(PIC) of the whole input image and the per-macroblock activity evaluation value ACT(MB) realizes appropriate denoising on a per macroblock basis depending on the noise level of the whole input image and the attribute of a macroblock.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the arithmetic circuit 20 (second arithmetic circuit) calculates a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a macroblock, and calculates an average of the sum of absolute difference in the macroblock to obtain the per-macroblock activity evaluation value ACT(MB).", "Thus the arithmetic circuit 20 appropriately obtains the activity evaluation value ACT(MB) on a per macroblock basis.", "In the image processor 1 according to the above embodiment, the setting circuit 22 sets the quantization value QP(MB) of a macroblock having a small activity evaluation value ACT(MB) to a quantization value larger than the quantization value QP(PIC).", "In a flat portion having a small activity evaluation value ACT(MB) where noise is noticeable, a large quantization value QP(MB) achieves high denoising effect by quantization.", "The setting circuit 22 sets the quantization value QP(MB) of a macroblock having a large activity evaluation value ACT(MB) to a quantization value smaller than the quantization value QP(PIC).", "In an edge or texture portion having a large activity evaluation value ACT(MB), a small quantization value QP(MB) prevents the edge or texture portion from blurring due to quantization, and thus improves image quality.", "The setting circuit 22 sets the quantization value QP(MB) of a macroblock having a medium activity evaluation value ACT(MB) to a value similar to the quantization value QP(PIC).", "In an image portion other than flat, edge, and texture portions, a medium quantization value QP(MB) avoids excessive or insufficient denoising effect on the image portion.", "In the image processor 1 according to the above embodiment, the setting circuit 22 sets a per-macroblock quantization value QP(MB) for quantization, on the basis of the quantization value QP(PIC) and the per-macroblock noise value NOISE(MB).", "The per-macroblock quantization value QP(MB) based on the quantization value QP(PIC) based on the noise value NOISE(PIC) of the whole input image and the per-macroblock noise value NOISE(MB) realizes appropriate denoising on a per macroblock basis depending on the noise level of the whole input image and the noise level per macroblock.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the setting circuit 22 increases the quantization value QP(MB) with increase in the noise value NOISE(MB) with the quantization value QP(PIC) being an upper limit.", "For a macroblock having a large noise value NOISE(MB), a large quantization value QP(MB) achieves high denoising effect by quantization.", "For a macroblock having a small noise value NOISE(MB), a small quantization value QP(MB) avoids image degradation due to quantization.", "Providing the upper limit at the quantization value QP(PIC) restricts the difference between the maximum and the minimum quantization value to a certain range, eliminating or reducing “floppiness”, and thus the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the setting circuit 23 sets the first correction value to the transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in the ideal image including no noise.", "Such first correction value realizes correction to bring the output image close to the ideal image, and thus improves image quality.", "In the image processor 1 according to the above embodiment, the setting circuit 24 (second correction value setting circuit) sets the per-macroblock scaling matrix SM(MB) (second correction value) for correction, on the basis of the first correction value and the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock second correction value based on the first correction value based on the image data D2 of the whole input image and the per-macroblock activity evaluation value ACT(MB) realizes appropriate correction on a per macroblock basis depending on the frequency component value of the whole input image and the attribute of a macroblock.", "In consequence, denoising effect per macroblock is improved and thus the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the setting circuit 24 holds multiple types of masks depending on the activity evaluation value ACT(MB), the masks containing arbitrary multipliers by frequency components, and performs masking on the first correction value using one of the masks corresponding to the activity evaluation value ACT(MB) calculated by the arithmetic circuit 20 to set the second correction value.", "In consequence, the second correction value depending on the per-macroblock activity evaluation value ACT(MB) is obtained simply and appropriately from the first correction value.", "In the image processor 1 according to the above embodiment, the setting circuit 24 sets the second correction value for a macroblock having a small activity evaluation value ACT(MB) to the first correction value for a low-frequency component, while setting the second correction value to substantially zero for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value ACT(MB) where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The setting circuit 24 sets the second correction value for a macroblock having a large activity evaluation value ACT(MB) to the first correction value for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value ACT(MB), masking not to cut off any frequency component realizes correction to sharpen the edge or texture portion, and thus improves image quality.", "The setting circuit 24 sets the second correction value for a macroblock having a medium activity evaluation value ACT(MB) to the first correction value for low- and middle-frequency components while setting the second correction value to substantially zero for a high-frequency component.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In the image processor 1 according to the above embodiment, the CPU 2 (determination circuit) determines whether denoising is to be performed on the basis of the noise value NOISE(PIC) of the whole input image and the activity evaluation value ACT(PIC) of the whole input image.", "Thus since denoising is performed on an input image that truly requires denoising while denoising on an input image that requires no denoising is avoided, power consumption is reduced.", "In the image processor 1 according to the above embodiment, the CPU 2 divides the noise value NOISE(PIC) of the whole input image by the activity evaluation value ACT(PIC) of the whole input image to calculate a noise strength.", "Then if the noise strength is lower than a predetermined threshold, denoising is determined to be unnecessary, while if the noise strength is higher than or equal to the threshold, denoising is determined to be necessary.", "Such determination by the CPU 2 achieves highly accurate identification of an input image that truly requires denoising.", "In the image processor 1 according to the above embodiment, the transform circuit 11, the quantization circuit 12, and the correction circuit 13 sequentially process partially-overlapping multiple macroblocks extracted from the input image.", "Partially overlapping macroblocks one another eliminates or reduces block noise.", "For a portion of the output image where multiple macroblocks overlap each other, an optimal value (average, in the above example) obtained from the overlapping macroblocks is output as image data of this portion of the image.", "Output of optimal value obtained from multiple macroblocks for overlapping portion realizes high denoising effect while avoiding image degradation.", "In the image processor 1 according to the above embodiment and second modification, the setting circuit 22 (quantization value setting circuit) sets the per-macroblock quantization value QP(MB) for quantization, on the basis of the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock quantization value QP(MB) based on the per-macroblock activity evaluation value ACT(MB) realizes appropriate denoising on a per macroblock basis depending on the attribute of a macroblock.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In the image processor 1 according to the above embodiment and second modification, the setting circuit 24 (correction value setting circuit) sets the per-macroblock scaling matrix SM(MB) (correction value) for correction, on the basis of the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock correction value based on the per-macroblock activity evaluation value ACT(MB) realizes appropriate correction on a per macroblock basis depending on the attribute of a macroblock.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the arithmetic circuit 20 calculates a sum of absolute difference between a smoothing value (weighted mean in the above example) of each pixel and an average smoothing value in a macroblock, and calculates an average of the sum of absolute difference in the macroblock to obtain a per-macroblock activity evaluation value ACT(MB).", "Thus the arithmetic circuit 20 appropriately obtains the activity evaluation value ACT(MB) on a per macroblock basis.", "In the image processor 1 according to the above embodiment, the setting circuit 22 sets the quantization value QP(MB) of a macroblock having a small activity evaluation value ACT(MB) to a large value.", "In a flat portion having a small activity evaluation value ACT(MB) where noise is noticeable, a large quantization value QP(MB) achieves high denoising effect by quantization.", "The setting circuit 22 sets the quantization value QP(MB) of a macroblock having a large activity evaluation value ACT(MB) to a small value.", "In an edge or texture portion having a large activity evaluation value ACT(MB), a small quantization value QP(MB) prevents the edge or texture portion from blurring due to quantization, and thus improves image quality.", "The setting circuit 22 sets the quantization value QP(MB) of a macroblock having a medium activity evaluation value ACT(MB) to a medium value.", "In an image portion other than flat, edge, and texture portions, a medium quantization value QP(MB) avoids excessive or insufficient denoising effect on the image portion.", "In the image processor 1 according to the above embodiment, the setting circuit 22 sets the per-macroblock quantization value QP(MB) for quantization, on the basis of the per-macroblock noise value NOISE(MB).", "The per-macroblock quantization value QP(MB) based on the per-macroblock noise value NOISE(MB) realizes appropriate denoising on a per macroblock basis depending on the noise level per macroblock.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In the image processor 1 according to the above embodiment, the setting circuit 24 sets the per-macroblock correction value for correction, on the basis of the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock correction value based on the per-macroblock activity evaluation value ACT(MB) realizes appropriate correction on a per macroblock basis depending on the attribute of a macroblock.", "In consequence, denoising effect per macroblock is improved and thus the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the setting circuit 22 increases the quantization value QP(MB) with increase in a noise value.", "For a macroblock having a large noise value, a large quantization value QP(MB) achieves high denoising effect by quantization.", "For a macroblock having a small noise value, a small quantization value QP(MB) avoids image degradation due to quantization.", "In the image processor 1 according to the above embodiment, the setting circuit 24 holds multiple types of masks depending on the activity evaluation value ACT(MB), the masks containing arbitrary multipliers by frequency components, and sets the correction value to the multiplier for one of the masks corresponding to the activity evaluation value ACT(MB) calculated by the arithmetic circuit 20.In consequence, the correction value depending on the per-macroblock activity evaluation value ACT(MB) is obtained simply and appropriately.", "In the image processor 1 according to the above embodiment, the setting circuit 24 sets the correction value for a macroblock having a small activity evaluation value ACT(MB) to one time for a low-frequency component, while setting the correction value to substantially zero time for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value ACT(MB) where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The setting circuit 24 sets the correction value for a macroblock having a large activity evaluation value ACT(MB) to one time for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value ACT(MB), masking not to cut off any frequency component realizes correction to sharpen the edge or texture portions, and thus improves image quality.", "The setting circuit set the correction value for a macroblock having a medium activity evaluation value ACT(MB) to one time for low- and middle-frequency components, while setting the correction value to substantially zero time for high-frequency components.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In the image processor 1 according to the above embodiment, the setting circuit 23 (first correction value setting circuit) sets the scaling matrix SM(PIC) (first correction value) per input image on the basis of the image data D2 (second image data) of the whole input image, and the correction circuit 13 performs correction per frequency component on the image data D3 (third image data) to generate the image data D4 (fourth image data).", "Correction per frequency component using the first correction value based on the image data D2 of the whole input image realizes appropriate denoising depending on a noise level per frequency component.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "the setting circuit 23 sets the first correction value to the transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in the ideal image including no noise.", "Such first correction value realizes correction to bring the output image close to the ideal image, and thus improves image quality.", "In the image processor 1 according to the above embodiment, the setting circuit 24 (correction value setting circuit) sets the per-macroblock scaling matrix SM(MB) (correction value) for correction, on the basis of the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock correction value based on the per-macroblock activity evaluation value ACT(MB) realizes appropriate correction on a per macroblock basis depending on the attribute of a macroblock.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "The setting circuit 24 holds multiple types of masks depending on the activity evaluation value ACT(MB), the masks containing arbitrary multipliers by frequency components, and sets the correction value to the multiplier for one of the masks corresponding to the activity evaluation value ACT(MB) calculated by the arithmetic circuit 20.In consequence the correction value depending on the per-macroblock activity evaluation value ACT(MB) is obtained simply and appropriately.", "While the invention has been described in detail, the foregoing description is in all aspects illustrative and not restrictive.", "It is understood that numerous other modifications and variations can be devised without departing from the scope of the invention." ] ]
Patent_15874303
[ [ "COAXIAL CABLE CONNECTOR WITH INTEGRAL RFI PROTECTION", "A coaxial cable connector for coupling an end of a coaxial cable to a terminal is disclosed.", "The connector has a coupler adapted to couple the connector to a terminal, a body assembled with the coupler and a post assembled with the coupler and the body.", "The post is adapted to receive an end of a coaxial cable.", "The post has an integral contacting portion that is monolithic with at least a portion of the post.", "When assembled the coupler and post provide at least one circuitous path resulting in RF shielding such that RF signals external to the coaxial cable connector are attenuated, such that the integrity of an electrical signal transmitted through coaxial cable connector is maintained regardless of the tightness of the coupling of the connector to the terminal." ], [ "1.-20.", "(canceled) 21.A coaxial cable connector for coupling an end of a coaxial cable to a terminal, the coaxial cable comprising an inner conductor, a dielectric surrounding the inner conductor, an outer conductor surrounding the dielectric, and a jacket surrounding the outer conductor, the connector comprising: a coupler configured to couple the connector to the terminal, the coupler comprising a front end, a rear end, a surface defining an inner bore disposed between the front end and the rear end of the coupler, and a lip extending inwardly into the inner bore of the coupler at a rear end of the coupler to define a forward facing surface of the lip; a body assembled with the coupler, the body comprising a forward portion and a rearward portion, the forward portion extending into the inner bore of the coupler and expanding radially outward in the inner bore of the coupler forward of the lip of the coupler to define a rearward facing annular surface opposing the forward facing surface of the lip of the coupler to limit forward axial movement of the coupler; and a post assembled with the coupler and the body, the post comprising a front end extending into the inner bore of the coupler through the rear end of the coupler, a rear end configured to receive the end of the coaxial cable connector, a flange at the front end of the post, an enlarged shoulder between the flange and the rear end of the post, and a contacting portion that is integral and monolithic with the post and extends from the enlarged shoulder into the inner bore of the coupler into contact with the surface defining the inner bore of the coupler.", "22.The coaxial cable connector of claim 21, wherein: the forward portion of the body further comprises a forward facing surface, the enlarged shoulder of the post defines a rearward facing annular surface of the post, and the forward facing surface of the forward portion of the body contacts the rearward facing annular surface of the post with the post in a rearward position.", "23.The coaxial cable connector of claim 21, wherein the body further comprises a forward facing annular surface that limits the rearward axial movement of the coupler.", "24.The coaxial cable connector of claim 23, wherein: the forward portion of the body further comprises a forward facing surface, the enlarged shoulder of the post defines a rearward facing annular surface of the post, and the forward facing surface of the forward portion of the body contacts the rearward facing annular surface of the post with the post in a rearward position.", "25.The coaxial cable connector of claim 23, wherein the forward facing annular surface of the body comprises: a vertical portion expanding radially outward from a middle portion of the body, and a diagonal portion expanding radially outward and rearward from the vertical portion of the forward facing annular surface of the rearward portion of the body.", "26.A coaxial cable connector for coupling an end of a coaxial cable to a terminal, the coaxial cable comprising an inner conductor, a dielectric surrounding the inner conductor, an outer conductor surrounding the dielectric, and a jacket surrounding the outer conductor, the connector comprising: a coupler comprising a front end, a rear end, a surface defining an inner bore disposed between the front end and the rear end, and a lip extending inwardly into the inner bore from the surface defining the inner bore, the lip comprising a forward facing surface and a rearward facing surface, the coupler configured to couple the connector to the terminal; a body assembled with the coupler, the body comprising a forward portion and a rearward portion, the forward portion of the body extending into the inner bore of the coupler and expanding radially outward in the inner bore of the coupler forward of the lip of the coupler to define a rearward facing annular surface opposing the forward facing surface of the lip of the coupler, the rearward portion of the body expanding radially outward behind the rear end of the coupler to define a forward facing annular surface opposing the rearward facing surface of the lip of the coupler; and a post assembled with the coupler and the body, the post comprising a front end extending into the inner bore of the coupler through the rear end of the coupler, wherein the post is configured to receive an end of a coaxial cable and the post comprises a flange, an outer surface, a contacting portion, an enlarged shoulder, and an inner surface, the outer surface of the post extends between the flange and the contacting portion of the post, the enlarged shoulder expands radially from the inner surface of the post and defines a rearward facing annular surface of the post extending between the inner surface of the post and the outer surface of the post, and the contacting portion of the post extends from the enlarged shoulder of the post over the outer surface of the post between the flange of the post and the enlarged shoulder of the post.", "27.A coaxial cable connector for coupling an end of a coaxial cable to a terminal, the coaxial cable comprising an inner conductor, a dielectric surrounding the inner conductor, an outer conductor surrounding the dielectric, and a jacket surrounding the outer conductor, the connector comprising: a coupler configured to couple the connector to the terminal, the coupler comprising a front end, a rear end, a surface defining an inner bore disposed between the front end and the rear end of the coupler, and a lip extending inwardly into the inner bore of the coupler at a rear end of the coupler to define a forward facing surface of the lip; a body assembled with the coupler, the body comprising a forward portion and a rearward portion and a forward facing annular surface between the forward portion and the rearward portion, the forward portion of the body extending into the inner bore of the coupler and expanding radially outward in the inner bore of the coupler forward of the lip of the coupler to define a forward facing surface and the forward facing annular surface of the body limiting the rearward axial movement of the coupler; and a post assembled with the coupler and the body, the post comprising a front end extending into the inner bore of the coupler through the rear end of the coupler, a rear end configured to receive the end of the coaxial cable connector, a flange at the front end of the post, an enlarged shoulder between the flange and the rear end of the post that defines a rearward facing annular surface of the post, and a contacting portion that is integral and monolithic with the post and extends from the enlarged shoulder into the inner bore of the coupler into contact with the surface defining the inner bore of the coupler, wherein the forward facing surface of the forward portion of the body contacts the rearward facing annular surface of the post with the post in a rearward position.", "28.The coaxial cable connector of claim 21, wherein RF signals external to the coaxial cable connector are attenuated by at least about 50 dB in a range up to about 1000 MHz.", "29.The coaxial cable connector of claim 28, wherein the RF signals external to the connector comprise RF signals that ingress into the connector.", "30.The coaxial cable connector of claim 28, wherein the RF signals external to the connector comprise RF signals that egress out from the connector.", "31.The coaxial cable connector of claim 21, wherein a transfer impedance measured from the outer conductor of the coaxial cable to the terminal through the connector averages less than about 0.24 ohms.", "32.The coaxial cable connector of claim 21, wherein a first circuitous path includes a plurality of pairs of electromagnetically coupled faces established by at least one of the lip, the flange, the contacting portion, and the enlarged shoulder, and wherein the first circuitous path attenuates of RF signals external to the connector.", "33.The coaxial cable connector of claim 21, wherein the terminal comprises an equipment connection port, and wherein the coupler comprises a threaded portion configured to connect with a threaded portion of an equipment connection port, and wherein at least one thread of the coupler has a pitch angle different than a pitch angle of at least one thread of the equipment connection port.", "34.The coaxial cable connector of claim 33, wherein the pitch angle of the thread of the coupler is about 2 degrees different than the pitch angle of the thread of the equipment connection port.", "35.The coaxial cable connector of claim 33, wherein the pitch angle of the thread of the coupler is about 62 degrees, and the pitch angle of the thread of the equipment connection port is about 60 degrees.", "36.The coaxial cable connector of claim 33, wherein the threaded portion of the coupler and the threaded portion of the equipment connection port, establish a second circuitous path that attenuates RF signals external to the connector." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY OF THE DETAILED DESCRIPTION <EOH>Embodiments disclosed herein include a coaxial cable connector having an inner conductor, a dielectric surrounding the inner conductor, an outer conductor surrounding the dielectric, and a jacket surrounding the outer conductor and used for coupling an end of a coaxial cable to an equipment connection port.", "The coaxial cable comprises a coupler, a body and a post.", "The coupler is adapted to couple the connector to the equipment connection port.", "The coupler and post provide RF shielding provides RF shielding of the assembled coaxial cable connector such that RF signals external to the coaxial cable connector are attenuated by at least about 50 dB in a range up to about 1000 MHz.", "A transfer impedance measured averages about 0.24 ohms.", "The integrity of an electrical signal transmitted through coaxial cable connector is maintained regardless of the tightness of the coupling of the connector to the equipment connection port.", "The RF signals external to the connector may be understood to mean RF signals that ingress into the connector.", "The RF signals external to the connector may also be understood to mean RF signals that egress out from the connector.", "The coupler may have a step and the post may have a flange, a contacting portion and a shoulder.", "A first circuitous path may be established by the a step, the flange, the contacting portion and the shoulder.", "The first circuitous path attenuates RF signals external to the connector.", "The coupler may have a threaded portion adapted to connect with a threaded portion of the equipment connection port.", "At least one thread on the coupler may have a pitch angle different than a pitch angle of at least one thread of the equipment connection port.", "The pitch angle of the thread of the coupler may be about 2 degrees different than the pitch angle of the thread of the equipment connection port.", "The pitch angle of the thread of the coupler may be about 62 degrees, and the pitch angle of the thread of the equipment connection port may be about 60 degrees.", "The threaded portion of the coupler and the threaded portion of the equipment connection port may establish a second circuitous path, and the second circuitous path may attenuate RF signals external to the connector.", "In yet another aspect, embodiments disclosed herein include a coaxial cable connector having an inner conductor, a dielectric surrounding the inner conductor, an outer conductor surrounding the dielectric, and a jacket surrounding the outer conductor and used for coupling an end of a coaxial cable to an equipment connection port.", "The coaxial cable comprises a coupler, a body and a post.", "The post comprises an integral contacting portion.", "The contacting portion is monolithic with at least a portion of the post.", "When assembled the coupler and post provide at least one circuitous path resulting in RF shielding such that RF signals external to the coaxial cable connector are attenuated, such that the integrity of an electrical signal transmitted through coaxial cable connector is maintained regardless of the tightness of the coupling of the connector to the terminal.", "RF signals external to the coaxial connector comprise at least one of RF signals that ingress into the connector and RF signals that egress out from the connector.", "RF signals are attenuated by at least about 50 dB in a range up to about 1000 MHz and a transfer impedance averages about 0.24 ohms.", "The at least one circuitous path comprises a first circuitous path and a second circuitous path.", "The coupler comprises a lip and a step, and the post comprises a flange and a shoulder.", "The first circuitous path is established by at least one of the step, the lip, the flange, the contacting portion and the shoulder.", "The terminal comprises an equipment connection port, and the coupler comprises a threaded portion adapted to connect with a threaded portion of the equipment connection port, and the threaded portion of the coupler and the threaded portion of the equipment connection port establish a second circuitous path.", "At least one thread on the coupler has a pitch angle different than a pitch angle of at least one thread of the equipment connection port.", "In yet another aspect, embodiments disclosed herein include a coaxial cable connector having an inner conductor, a dielectric surrounding the inner conductor, an outer conductor surrounding the dielectric, and a jacket surrounding the outer conductor and used for coupling an end of a coaxial cable to an equipment connection port.", "The coaxial cable comprises a coupler, a body and a post.", "The coupler is adapted to couple the connector to the equipment connection port.", "The coupler has a step and a threaded portion adapted to connect with a threaded portion of the equipment connection port.", "At least one thread on the coupler has a pitch angle different than a pitch angle of at least one thread of the equipment connection port.", "The body is assembled with the coupler.", "The post is assembled with the coupler and the body and is adapted to receive an end of a coaxial cable.", "The post comprises a flange, a contacting portion and a shoulder.", "A first circuitous path is established by the a step, the flange, the contacting portion and the shoulder.", "A second circuitous path is established by the threaded portion of the coupler and the threaded portion of the equipment connection port.", "The first circuitous path and the second circuitous path provide for RF shielding of the assembled coaxial cable connector wherein RF signals external to the coaxial cable connector are attenuated by at least about 50 dB in a range up to about 1000 MHz, and the integrity of an electrical signal transmitted through coaxial cable connector is maintained regardless of the tightness of the coupling of the connector to the equipment connection port.", "A transfer impedance averages about 0.24 ohms.", "Additionally, the pitch angle of the thread of the coupler may be about 2 degrees different than the pitch angle of the thread of the equipment connection port.", "As a non-limiting example, the pitch angle of the thread of the coupler may be about 62 degrees, and the pitch angle of the thread of the equipment connection port is about 60 degrees.", "Additional features and advantages are set out in the detailed description which follows, and in part will be readily apparent to those skilled in the art from that description or recognized by practicing the embodiments as described herein, including the detailed description, the claims, as well as the appended drawings.", "It is to be understood that both the foregoing general description and the following detailed description are merely exemplary, and are intended to provide an overview or framework to understanding the nature and character of the claims.", "The accompanying drawings are included to provide a further understanding, and are incorporated in and constitute a part of this specification.", "The drawings illustrate one or more embodiment(s), and together with the description serve to explain principles and operation of the various embodiments." ], [ "RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "15/636,842, filed Jun.", "29, 2017, entitled “Coaxial Cable Connector with Integral RFI Protection,” which is a continuation of U.S. application Ser.", "No.", "15/019,498, filed Feb. 9, 2016, entitled “Coaxial Cable Connector With Integral RFI Protection,” which is a continuation of U.S. application Ser.", "No.", "13/653,095, filed Oct. 16, 2012, entitled “Coaxial Cable Connector With Integral RFI Protection,” the disclosures of which are incorporated herein by reference in their entirety.", "This application is related to U.S. application Ser.", "No.", "13/198,765, filed Aug. 5, 2011, entitled “Coaxial Cable Connector with Radio Frequency Interference and Grounding Shield,” which is incorporated herein by reference in its entirety.", "This application is also related to U.S. application Ser.", "No.", "13/652,969, filed Oct. 16, 2012, entitled “Coaxial Cable Connector with Continuity Contacting Portion,” which is incorporated herein by reference in its entirety.", "BACKGROUND Field of the Disclosure The technology of the disclosure relates to coaxial cable connectors and, in particular, to a coaxial cable connector that provides integral radio frequency interference (RFI) shielding.", "Technical Background Coaxial cable connectors, such as type F connectors, are used to attach coaxial cable to another object or appliance, e.g., a television set, DVD player, modem or other electronic communication device having a terminal adapted to engage the connector.", "The terminal of the appliance includes an inner conductor and a surrounding outer conductor.", "Coaxial cable includes a center conductor for transmitting a signal.", "The center conductor is surrounded by a dielectric material, and the dielectric material is surrounded by an outer conductor; this outer conductor may be in the form of a conductive foil and/or braided sheath.", "The outer conductor is typically maintained at ground potential to shield the signal transmitted by the center conductor from stray noise, and to maintain a continuous desired impedance over the signal path.", "The outer conductor is usually surrounded by a plastic cable jacket that electrically insulates, and mechanically protects, the outer conductor.", "Prior to installing a coaxial connector onto an end of the coaxial cable, the end of the coaxial cable is typically prepared by stripping off the end portion of the jacket to expose the end portion of the outer conductor.", "Similarly, it is common to strip off a portion of the dielectric to expose the end portion of the center conductor.", "Coaxial cable connectors of the type known in the trade as “F connectors” often include a tubular post designed to slide over the dielectric material, and under the outer conductor of the coaxial cable, at the prepared end of the coaxial cable.", "If the outer conductor of the cable includes a braided sheath, then the exposed braided sheath is usually folded back over the cable jacket.", "The cable jacket and folded-back outer conductor extend generally around the outside of the tubular post and are typically received in an outer body of the connector; this outer body of the connector is often fixedly secured to the tubular post.", "A coupler is typically rotatably secured around the tubular post and includes an internally-threaded region for engaging external threads formed on the outer conductor of the appliance terminal.", "When connecting the end of a coaxial cable to a terminal of a television set, equipment box, modem, computer or other appliance, it is important to achieve a reliable electrical connection between the outer conductor of the coaxial cable and the outer conductor of the appliance terminal.", "Typically, this goal is usually achieved by ensuring that the coupler of the connector is fully tightened over the connection port of the appliance.", "When fully tightened, the head of the tubular post of the connector directly engages the edge of the outer conductor of the appliance port, thereby making a direct electrical ground connection between the outer conductor of the appliance port and the tubular post; in turn, the tubular post is engaged with the outer conductor of the coaxial cable.", "With the increased use of self-install kits provided to home owners by some CATV system operators has come a rise in customer complaints due to poor picture quality in video systems and/or poor data performance in computer/internet systems.", "Additionally, CATV system operators have found upstream data problems induced by entrance of unwanted radio frequency (“RF”) signals into their systems.", "Complaints of this nature result in CATV system operators having to send a technician to address the issue.", "Often times it is reported by the technician that the cause of the problem is due to a loose F connector fitting, sometimes as a result of inadequate installation of the self-install kit by the homeowner.", "An improperly installed or loose connector may result in poor signal transfer because there are discontinuities along the electrical path between the devices, resulting in ingress of undesired RF signals where RF energy from an external source or sources may enter the connector/cable arrangement causing a signal to noise ratio problem resulting in an unacceptable picture or data performance.", "In particular, RF signals may enter CATV systems from wireless devices, such as cell phones, computers and the like, especially in the 700-800 MHz transmitting range.", "Many of the current state of the art F connectors rely on intimate contact between the F male connector interface and the F female connector interface.", "If, for some reason, the connector interfaces are allowed to pull apart from each other, such as in the case of a loose F male coupler, an interface “gap” may result.", "If not otherwise protected this gap can be a point of RF ingress as previously described.", "A shield that completely surrounds or encloses a structure or device to protect it against RFI is typically referred to as a “Faraday cage.” However, providing such RFI shielding within given structures is complicated when the structure or device comprises moving parts, such as seen in a coaxial connector.", "Accordingly, creating a connector to act in a manner similar to a Faraday cage to prevent ingress and egress of RF signals can be especially challenging due to the necessary relative movement between connector components required to couple the connector to a related port.", "Relative movement of components due to mechanical clearances between the components can result in an ingress or egress path for unwanted RF signals and, further, can disrupt the electrical and mechanical communication between components necessary to provide a reliable ground path.", "The effort to shield and electrically ground a coaxial connector is further complicated when the connector is required to perform when improperly installed, i.e.", "not tightened to a corresponding port.", "U.S. Pat.", "No.", "5,761,053 to, teaches that “[e]lectromagnetic interference (EMI) has been defined as undesired conducted or radiated electrical disturbances from an electrical or electronic apparatus, including transients, which can interfere with the operation of other electrical or electronic apparatus.", "Such disturbances can occur anywhere in the electromagnetic spectrum.", "Radio frequency interference (RFI) is often used interchangeably with electromagnetic interference, although it is more properly restricted to the radio frequency portion of the electromagnetic spectrum, usually defined as between 24 kilohertz (kHz) and 240 gigahertz (GHz).", "A shield is defined as a metallic or otherwise electrically conductive configuration inserted between a source of EMI/RFI and a desired area of protection.", "Such a shield may be provided to prevent electromagnetic energy from radiating from a source.", "Additionally, such a shield may prevent external electromagnetic energy from entering the shielded system.", "As a practical matter, such shields normally take the form of an electrically conductive housing which is electrically grounded.", "The energy of the EMI/RFI is thereby dissipated harmlessly to ground.", "Because EMI/RFI disrupts the operation of electronic components, such as integrated circuit (IC) chips, IC packages, hybrid components, and multi-chip modules, various methods have been used to contain EMI/RFI from electronic components.", "The most common method is to electrically ground a “can”, that will cover the electronic components, to a substrate such as a printed wiring board.", "As is well known, a can is a shield that may be in the form of a conductive housing, a metallized cover, a small metal box, a perforated conductive case wherein spaces are arranged to minimize radiation over a given frequency band, or any other form of a conductive surface that surrounds electronic components.", "When the can is mounted on a substrate such that it completely surrounds and encloses the electronic components, it is often referred to as a Faraday Cage.", "Presently, there are two predominant methods to form a Faraday cage around electronic components for shielding use.", "A first method is to solder a can to a ground strip that surrounds electronic components on a printed wiring board (PWB).", "Although soldering a can provides excellent electrical properties, this method is often labor intensive.", "Also, a soldered can is difficult to remove if an electronic component needs to be re-worked.", "A second method is to mechanically secure a can, or other enclosure, with a suitable mechanical fastener, such as a plurality of screws or a clamp, for example.", "Typically, a conductive gasket material is usually attached to the bottom surface of a can to ensure good electrical contact with the ground strip on the PWB.", "Mechanically securing a can facilitates the re-work of electronic components, however, mechanical fasteners are bulky and occupy “valuable” space on a PWB.” Coaxial cable connectors have attempted to address the above problems by incorporating a continuity member into the coaxial cable connector as a separate component.", "In this regard, FIG.", "1 illustrates a connector 1000 in the prior art having a coupler 2000, a separate post 3000, a separate continuity member 4000, and a body 5000.In connector 1000 the separate continuity member 4000 is captured between post 3000 and body 5000 and contacts at least a portion of coupler 2000.Coupler 2000 is preferably made of metal such as brass and plated with a conductive material such as nickel.", "Post 3000 is preferably made of metal such as brass and plated with a conductive material such as tin.", "Separate conductive member 4000 is preferably made of metal such as phosphor bronze and plated with a conductive material such as tin.", "Body 5000 is preferably made of metal such as brass and plated with a conductive material such as nickel.", "SUMMARY OF THE DETAILED DESCRIPTION Embodiments disclosed herein include a coaxial cable connector having an inner conductor, a dielectric surrounding the inner conductor, an outer conductor surrounding the dielectric, and a jacket surrounding the outer conductor and used for coupling an end of a coaxial cable to an equipment connection port.", "The coaxial cable comprises a coupler, a body and a post.", "The coupler is adapted to couple the connector to the equipment connection port.", "The coupler and post provide RF shielding provides RF shielding of the assembled coaxial cable connector such that RF signals external to the coaxial cable connector are attenuated by at least about 50 dB in a range up to about 1000 MHz.", "A transfer impedance measured averages about 0.24 ohms.", "The integrity of an electrical signal transmitted through coaxial cable connector is maintained regardless of the tightness of the coupling of the connector to the equipment connection port.", "The RF signals external to the connector may be understood to mean RF signals that ingress into the connector.", "The RF signals external to the connector may also be understood to mean RF signals that egress out from the connector.", "The coupler may have a step and the post may have a flange, a contacting portion and a shoulder.", "A first circuitous path may be established by the a step, the flange, the contacting portion and the shoulder.", "The first circuitous path attenuates RF signals external to the connector.", "The coupler may have a threaded portion adapted to connect with a threaded portion of the equipment connection port.", "At least one thread on the coupler may have a pitch angle different than a pitch angle of at least one thread of the equipment connection port.", "The pitch angle of the thread of the coupler may be about 2 degrees different than the pitch angle of the thread of the equipment connection port.", "The pitch angle of the thread of the coupler may be about 62 degrees, and the pitch angle of the thread of the equipment connection port may be about 60 degrees.", "The threaded portion of the coupler and the threaded portion of the equipment connection port may establish a second circuitous path, and the second circuitous path may attenuate RF signals external to the connector.", "In yet another aspect, embodiments disclosed herein include a coaxial cable connector having an inner conductor, a dielectric surrounding the inner conductor, an outer conductor surrounding the dielectric, and a jacket surrounding the outer conductor and used for coupling an end of a coaxial cable to an equipment connection port.", "The coaxial cable comprises a coupler, a body and a post.", "The post comprises an integral contacting portion.", "The contacting portion is monolithic with at least a portion of the post.", "When assembled the coupler and post provide at least one circuitous path resulting in RF shielding such that RF signals external to the coaxial cable connector are attenuated, such that the integrity of an electrical signal transmitted through coaxial cable connector is maintained regardless of the tightness of the coupling of the connector to the terminal.", "RF signals external to the coaxial connector comprise at least one of RF signals that ingress into the connector and RF signals that egress out from the connector.", "RF signals are attenuated by at least about 50 dB in a range up to about 1000 MHz and a transfer impedance averages about 0.24 ohms.", "The at least one circuitous path comprises a first circuitous path and a second circuitous path.", "The coupler comprises a lip and a step, and the post comprises a flange and a shoulder.", "The first circuitous path is established by at least one of the step, the lip, the flange, the contacting portion and the shoulder.", "The terminal comprises an equipment connection port, and the coupler comprises a threaded portion adapted to connect with a threaded portion of the equipment connection port, and the threaded portion of the coupler and the threaded portion of the equipment connection port establish a second circuitous path.", "At least one thread on the coupler has a pitch angle different than a pitch angle of at least one thread of the equipment connection port.", "In yet another aspect, embodiments disclosed herein include a coaxial cable connector having an inner conductor, a dielectric surrounding the inner conductor, an outer conductor surrounding the dielectric, and a jacket surrounding the outer conductor and used for coupling an end of a coaxial cable to an equipment connection port.", "The coaxial cable comprises a coupler, a body and a post.", "The coupler is adapted to couple the connector to the equipment connection port.", "The coupler has a step and a threaded portion adapted to connect with a threaded portion of the equipment connection port.", "At least one thread on the coupler has a pitch angle different than a pitch angle of at least one thread of the equipment connection port.", "The body is assembled with the coupler.", "The post is assembled with the coupler and the body and is adapted to receive an end of a coaxial cable.", "The post comprises a flange, a contacting portion and a shoulder.", "A first circuitous path is established by the a step, the flange, the contacting portion and the shoulder.", "A second circuitous path is established by the threaded portion of the coupler and the threaded portion of the equipment connection port.", "The first circuitous path and the second circuitous path provide for RF shielding of the assembled coaxial cable connector wherein RF signals external to the coaxial cable connector are attenuated by at least about 50 dB in a range up to about 1000 MHz, and the integrity of an electrical signal transmitted through coaxial cable connector is maintained regardless of the tightness of the coupling of the connector to the equipment connection port.", "A transfer impedance averages about 0.24 ohms.", "Additionally, the pitch angle of the thread of the coupler may be about 2 degrees different than the pitch angle of the thread of the equipment connection port.", "As a non-limiting example, the pitch angle of the thread of the coupler may be about 62 degrees, and the pitch angle of the thread of the equipment connection port is about 60 degrees.", "Additional features and advantages are set out in the detailed description which follows, and in part will be readily apparent to those skilled in the art from that description or recognized by practicing the embodiments as described herein, including the detailed description, the claims, as well as the appended drawings.", "It is to be understood that both the foregoing general description and the following detailed description are merely exemplary, and are intended to provide an overview or framework to understanding the nature and character of the claims.", "The accompanying drawings are included to provide a further understanding, and are incorporated in and constitute a part of this specification.", "The drawings illustrate one or more embodiment(s), and together with the description serve to explain principles and operation of the various embodiments.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a side cross sectional view of a coaxial cable connector in the prior art; FIG.", "2 is a side, cross sectional view of an exemplary embodiment of a coaxial connector comprising a post with a contacting portion providing an integral RFI and grounding shield; FIG.", "3A is side, cross-sectional view of the coaxial cable connector of FIG.", "2 in a state of partial assembly; FIG.", "3B is a partial, cross-sectional detail view of the post of the coaxial cable connector of FIG.", "2 in a state of further assembly than as illustrated in FIG.", "3A, and illustrating the contacting portion of the post beginning to form to a contour of the coupler; FIG.", "3C is a partial, cross-sectional detail view of the post of the coaxial cable connector of FIG.", "2 in a state of further assembly than as illustrated in FIGS.", "3A and 3B, and illustrating the contacting portion of the post continuing to form to a contour of the coupler; FIG.", "3D is a partial, cross-sectional detail view of the post of the coaxial cable connector of FIG.", "2 in a state of further assembly than as illustrated in FIGS.", "3A, 3B and 3C and illustrating the contacting portion of the post forming to a contour of the coupler; FIG.", "4A is a partial, cross-sectional view of the post of the coaxial cable connector of FIG.", "2 in which the post is partially inserted into a forming tool; FIG.", "4B is a partial, cross-sectional detail view of the post of the coaxial cable connector of FIG.", "2 in which the post is inserted into the forming tool further than as illustrated in FIG.", "4A using a forming tool and illustrating the contacting portion of the post beginning to form to a contour of the forming tool; FIG.", "4C is a partial cross-sectional detail view of the post of the coaxial cable connector of FIG.", "2 in in which the post is inserted into the forming tool further than as illustrated in FIGS.", "4A and 4B illustrating the contacting portion of the post continuing to form to the contour of the forming tool; FIG.", "4D is a partial cross-sectional detail view of the post of the coaxial cable connector of FIG.", "2 in which the post is fully inserted into the forming tool and illustrating the contacting portion of the post forming to the contour of the forming tool; FIGS.", "5A through 5H are front and side schematic views of exemplary embodiments of the contacting portions of the post; FIG.", "6 is a cross-sectional view of an exemplary embodiment of a coaxial cable connector comprising an integral pin, in the state of assembly with body having a contacting portion forming to a contour of the coupler; FIG.", "6A is a cross-sectional view of the coaxial cable connector illustrated in FIG.", "6 in a partial state of assembly illustrating the contacting portion of the body and adapted to form to a contour of the coupler; FIG.", "7 is a cross-sectional view of an exemplary embodiment of a coaxial cable connector comprising an integral pin, wherein the coupler rotates about a body instead of a post and the contacting portion is part of a component press fit into the body and forming to a contour of the coupler; FIG.", "8 is a cross-sectional view of an exemplary embodiment of a coaxial cable connector in a partial state of assembly and comprising an integral pin, wherein the coupler rotates about a body instead of a post and the contacting portion is part of a component press position in the body and forming to a contour of the coupler; FIG.", "8A is a front and side detail view of the component having the contacting portion of the coaxial cable connector of FIG.", "8; FIG.", "9 is a cross sectional view of an exemplary embodiment of a coaxial cable connector comprising a post-less configuration, and a body having a contacting portion forming to a contour of the coupler; FIG.", "10 is a cross sectional view of an exemplary embodiment of a coaxial cable connector comprising a hex crimp body and a post having a contacting portion forming to a contour of the coupler; FIG.", "11 is an isometric, schematic view of the post of the coaxial cable connector of FIG.", "2 wherein the post has a contacting portion in a formed state; FIG.", "12 is an isometric, cross-sectional view of the post and the coupler of the coaxial cable connector of FIG.", "2 illustrating the contacting portion of the post forming to a contour of the coupler; FIG.", "13 is a cross-sectional view of an exemplary embodiment of a coaxial cable connector having a coupler with a contacting portion forming to a contour of the post; FIG.", "14 is a cross-sectional view of an exemplary embodiment of a coaxial cable connector having a post with a contacting portion forming to a contour of the coupler; FIG.", "15 is a cross-sectional view of an exemplary embodiment of a coaxial cable connector having a post with a contacting portion forming to a contour behind a lip in the coupler toward the rear of the coaxial cable connector; FIG.", "16 is a cross-sectional view of an exemplary embodiment of a coaxial cable connector having a post with a contacting portion forming to a contour behind a lip in the coupler toward the rear of the coaxial cable connector; FIG.", "17 is a cross-sectional view of an exemplary embodiment of a coaxial cable connector having a body with a contacting portion forming to a contour behind a lip in the coupler toward the rear of the coaxial cable connector; FIG.", "18 is a cross-sectional view of an exemplary embodiment of a coaxial cable connector having a post with a contacting portion forming to a contour of a coupler with an undercut; FIG.", "18A is a partial, cross-sectional view of an exemplary embodiment of a coaxial cable connector having a post with a contacting portion forming to a contour of a coupler with an undercut having a prepared coaxial cable inserted in the coaxial cable connector; FIG.", "19 is a partial, cross-sectional view of an exemplary embodiment of a coaxial cable connector having a moveable post with a contacting portion wherein the post is in a forward position; FIG.", "20 is a partial cross sectional view of the coaxial cable connector of FIG.", "19 with the movable post in a rearward position and the contacting portion of the movable post forming to a contour of the coupler; FIG.", "21 is a side, cross sectional view of an exemplary embodiment of an assembled coaxial cable connector providing for circuitous electrical paths at the coupler to form an integral Faraday cage for RF protection; FIG.", "22 is a partial, cross-sectional detail view of the assembled coaxial cable connector of FIG.", "21 illustrating a circuitous path between the coupler, post and body another circuitous path between the coupler and the equipment connection port; FIG.", "23 is a partial, cross sectional detail view of the coupler, the post and the body of FIG.", "22.FIG.", "24 is a partial, cross-sectional detail view of the threads of an equipment connection port and the threads of the coupler of the assembled coaxial cable connector of FIG.", "22; and FIG.", "25 is a graphic representation of the RF shielding of the coaxial cable connector in FIG.", "21 in which the RF shielding is measured in dB over a range of frequency in MHz.", "DETAILED DESCRIPTION Reference will now be made in detail to the embodiments, examples of which are illustrated in the accompanying drawings, in which some, but not all embodiments are shown.", "Indeed, the concepts may be embodied in many different forms and should not be construed as limiting herein.", "Rather, these embodiments are provided so that this disclosure will satisfy applicable legal requirements.", "Whenever possible, like reference numbers will be used to refer to like components or parts.", "Coaxial cable connectors are used to couple a prepared end of a coaxial cable to a threaded female equipment connection port of an appliance.", "The coaxial cable connector may have a post, a moveable post or be postless.", "In each case though, in addition to providing an electrical and mechanical connection between the conductor of the coaxial connector and the conductor of the female equipment connection port, the coaxial cable connector provides a ground path from an outer conductor of the coaxial cable to the equipment connection port.", "The outer conductor may be, as examples, a conductive foil or a braided sheath.", "Maintaining a stable ground path protects against the ingress of undesired radio frequency (“RF”) signals which may degrade performance of the appliance.", "This is especially applicable when the coaxial cable connector is not fully tightened to the equipment connection port, either due to not being tightened upon initial installation or due to becoming loose after installation.", "Embodiments disclosed herein include a coaxial cable connector having an inner conductor, a dielectric surrounding the inner conductor, an outer conductor surrounding the dielectric, and a jacket surrounding the outer conductor and used for coupling an end of a coaxial cable to an equipment connection port.", "The coaxial cable comprises a coupler, a body and a post.", "The coupler is adapted to couple the connector to the equipment connection port.", "The coupler has a step and a threaded portion adapted to connect with a threaded portion of the equipment connection port.", "At least one thread on the coupler has a pitch angle different than a pitch angle of at least one thread of the equipment connection port.", "The body is assembled with the coupler.", "The post is assembled with the coupler and the body and is adapted to receive an end of a coaxial cable.", "The post comprises a flange, a contacting portion and a shoulder.", "The contacting portion is integral and monolithic with at least a portion of the post.", "A first circuitous path is established by the a step, the flange, the contacting portion and the shoulder.", "A second circuitous path is established by the threaded portion of the coupler and the threaded portion of the equipment connection port.", "The first circuitous path and the second circuitous path provide for RF shielding of the assembled coaxial cable connector wherein RF signals external to the coaxial cable connector are attenuated by at least about 50 dB in a range up to about 1000 MHz, and the integrity of an electrical signal transmitted through coaxial cable connector is maintained regardless of the tightness of the coupling of the connector to the equipment connection port.", "A transfer impedance averages about 0.24 ohms.", "Additionally, the pitch angle of the thread of the coupler may be about 2 degrees different than the pitch angle of the thread of the equipment connection port.", "As a non-limiting example, the pitch angle of the thread of the coupler may be about 62 degrees, and the pitch angle of the thread of the equipment connection port is about 60 degrees.", "For purposes of this description, the term “forward” will be used to refer to a direction toward the portion of the coaxial cable connector that attaches to a terminal, such as an appliance equipment port.", "The term “rearward” will be used to refer to a direction that is toward the portion of the coaxial cable connector that receives the coaxial cable.", "The term “terminal” will be used to refer to any type of connection medium to which the coaxial cable connector may be coupled, as examples, an appliance equipment port, any other type of connection port, or an intermediate termination device.", "Additionally, for purposes herein, electrical continuity shall mean DC contact resistance from the outer conductor of the coaxial cable to the equipment port of less than about 3000 milliohms.", "Accordingly, a DC contact resistance of more than about 3000 milliohms shall be considered as indicating electrical discontinuity or an open in the path between the outer conductor of the coaxial cable and the equipment port.", "Referring now to FIG.", "2, there is illustrated an exemplary embodiment of a coaxial cable connector 100.The coaxial cable connector 100 has a front end 105, a back end 195, a coupler 200, a post 300, a body 500, a shell 600 and a gripping member 700.The coupler 200 at least partially comprises a front end 205, a back end 295, a central passage 210, a lip 215 with a forward facing surface 216 and a rearward facing surface 217, a through-bore 220 formed by the lip 215, and a bore 230.Coupler 200 is preferably made of metal such as brass and plated with a conductive material such as nickel.", "Alternately or additionally, selected surfaces of the coupler 200 may be coated with conductive or non-conductive coatings or lubricants, or a combinations thereof.", "Post 300, may be tubular, at least partially comprises a front end 305, a back end 395, and a contacting portion 310.In FIG.", "2, Contacting portion 310 is shown as a protrusion integrally formed and monolithic with post 300.Contacting portion 310 may, but does not have to be, radially projecting.", "Post 300 may also comprise an enlarged shoulder 340, a collar portion 320, a through-bore 325, a rearward facing annular surface 330, and a barbed portion 335 proximate the back end 395.The post 300 is preferably made of metal such as brass and plated with a conductive material such as tin.", "Additionally, the material, in an exemplary embodiment, may have a suitable spring characteristic permitting contacting portion 310 to be flexible, as described below.", "Alternately or additionally, selected surfaces of post 300 may be coated with conductive or non-conductive coatings or lubricants or a combination thereof.", "Contacting portion 310, as noted above, is monolithic with post 300 and provides for electrical continuity through the connector 100 to an equipment port (not shown in FIG.", "2) to which connector 100 may be coupled.", "In this manner, post 300 provides for a stable ground path through the connector 100, and, thereby, electromagnetic shielding to protect against the ingress and egress of RF signals.", "Body 500 at least partially comprises a front end 505, a back end 595, and a central passage 525.Body 500 is preferably made of metal such as brass and plated with a conductive material such as nickel.", "Shell 600 at least partially comprises a front end 605, a back end 695, and a central passage 625.Shell 600 is preferably made of metal such as brass and plated with a conductive material such as nickel.", "Gripping member 700 at least partially comprises a front end 705, a back end 795, and a central passage 725.Gripping member 700 is preferably made of a suitable polymer material such as acetal or nylon.", "The resin can be selected from thermoplastics characterized by good fatigue life, low moisture sensitivity, high resistance to solvents and chemicals, and good electrical properties.", "In FIG.", "2, coaxial cable connector 100 is shown in an unattached, uncompressed state, without a coaxial cable inserted therein.", "Coaxial cable connector 100 couples a prepared end of a coaxial cable to a terminal, such as a threaded female equipment appliance connection port (not shown in FIG.", "2).", "This will be discussed in more detail with reference to FIG.", "18A.", "Shell 600 slideably attaches to body 500 at back end 595 of body 500.Coupler 200 attaches to coaxial cable connector 100 at back end 295 of coupler 200.Coupler 200 may rotatably attach to front end 305 of post 300 while engaging body 500 by means of a press-fit.", "Front end 305 of post 300 positions in central passage 210 of coupler 200 and has a back end 395 which is adapted to extend into a coaxial cable.", "Proximate back end 395, post 300 has a barbed portion 335 extending radially outwardly from post 300.An enlarged shoulder 340 at front end 305 extends inside the coupler 200.Enlarged shoulder 340 comprises a collar portion 320 and a rearward facing annular surface 330.Collar portion 320 allows coupler 200 to rotate by means of a clearance fit with through-bore 220 of coupler 200.Rearward facing annular surface 330 limits forward axial movement of the coupler 200 by engaging forward facing surface 216 of lip 215.Coaxial cable connector 100 may also include a sealing ring 800 seated within coupler 200 to form a seal between coupler 200 and body 500.Contacting portion 310 may be monolithic with or a unitized portion of post 300.As such, contacting portion 310 and post 300 or a portion of post 300 may be constructed from a single piece of material.", "The contacting portion 310 may contact coupler 200 at a position that is forward of forward facing surface 216 of lip 215.In this way, contacting portion 310 of post 300 provides an electrically conductive path between post 300, coupler 200 and body 500.This enables an electrically conductive path from coaxial cable through coaxial cable connector 100 to terminal providing an electrical ground and a shield against RF ingress and egress.", "Contacting portion 310 is formable such that as the coaxial cable connector 100 is assembled, contacting portion 310 may form to a contour of coupler 200.In other words, coupler 200 forms or shapes contacting portion 310 of post 300.The forming and shaping of the contacting portion 310 may have certain elastic/plastic properties based on the material of contacting portion 310.Contacting portion 310 deforms , upon assembly of the components of coaxial cable connector 100, or, alternatively contacting portion 310 of post 300 may be pre-formed, or partially preformed to electrically contactedly fit with coupler 200 as explained in greater detail with reference to FIG.", "4A through FIG.", "4D, below.", "In this manner, post 300 is secured within coaxial cable connector 100, and contacting portion 310 establishes an electrically conductive path between body 500 and coupler 200.Further, the electrically conductive path remains established regardless of the tightness of the coaxial cable connector 100 on the terminal due to the elastic/plastic properties of contacting portion 310.This is due to contacting portion 310 maintaining mechanical and electrical contact between components, in this case, post 300 and coupler 200, notwithstanding the size of any interstice between the components of the coaxial cable connector 100.In other words, contacting portion 310 is integral to and maintains the electrically conductive path established between post 300 and coupler 200 even when the coaxial cable connector 100 is loosened and/or partially disconnected from the terminal, provided there is some contact of coupler 200 with equipment port.", "Although coaxial connector 100 in FIG.", "2 is an axial-compression type coaxial connector having a post 300, contacting portion 310 may be integral to and monolithic with any type of coaxial cable connector and any other component of a coaxial cable connector, examples of which will be discussed herein with reference to the embodiments.", "However, in all such exemplary embodiments, contacting portion 310 provides for electrical continuity from an outer conductor of a coaxial cable received by coaxial cable connector 100 through coaxial cable connector 100 to a terminal, without the need for a separate component.", "Additionally, the contacting portion 310 provides for electrical continuity regardless of how tight or loose the coupler is to the terminal.", "In other words, contacting portion 310 provides for electrical continuity from the outer conductor of the coaxial cable to the terminal regardless and/or irrespective of the tightness or adequacy of the coupling of the coaxial cable connector 100 to the terminal.", "It is only necessary that the coupler 200 be in contact with the terminal.", "Referring now to FIGS.", "3A, 3B 3C and 3D, post 300 is illustrated in different states of assembly with coupler 200 and body 500.In FIG.", "3A, post 300 is illustrated partially assembled with coupler 200 and body 500 with contacting portion 310 of post 300, shown as a protrusion, outside and forward of coupler 200.Contacting portion 310 may, but does not have to be, radially projecting.", "In FIG.", "3B, contacting portion 310 has begun to advance into coupler 200 and contacting portion 310 is beginning to form to a contour of coupler 200.As illustrated in FIG.", "3B, contacting portion 310 is forming to an arcuate or, at least, a partially arcuate shape.", "As post 300 is further advanced into coupler 200 as shown in FIG.", "3C, contacting portion 310 continues to form to the contour of coupler 200.When assembled as shown in FIG.", "3D, contacting portion 310 is forming to the contour of coupler 200 and is contactedly engaged with bore 230 accommodating tolerance variations with bore 230.In FIG.", "3D coupler 200 has a face portion 202 that tapers.", "The face portion 202 guides the contacting portion 310 to its formed state during assembly in a manner that does not compromise its structural integrity, and, thereby, its elastic/plastic property.", "Face portion 202 may be or have other structural features, as a non-limiting example, a curved edge, to guide the contacting portion 310.The flexible or resilient nature of the contacting portion 310 in the formed state as described above, permits coupler 200 to be easily rotated and yet maintain a reliable electrically conductive path.", "It should be understood, that contacting portion 310 is formable and, as such, may exist in an unformed and a formed state based on the elastic/plastic property of the material of contacting portion 310.As the coaxial cable connector 100 assembles contacting portion 310 transition from an unformed state to a formed state.", "Referring now to FIGS.", "4A, 4B, 4C and 4D the post 300 is illustrated in different states of insertion into a forming tool 900.In FIG.", "4A, post 300 is illustrated partially inserted in forming tool 900 with contacting portion 310 of post 300 shown as a protrusion.", "Protrusion may, but does not have to be radially projecting.", "In FIG.", "4B, contacting portion 310 has begun to advance into forming tool 900.As contacting portion 310 is advanced into forming tool 900, contact portion 310 begins flexibly forming to a contour of the interior of forming tool 900.As illustrated in FIG.", "4B, contacting portion 310 is forming to an arcuate or, at least, a partially arcuate shape.", "As post 300 is further advanced into forming tool 900 as shown in FIG.", "4C, contacting portion 310 continues forming to the contour of the interior of forming tool 900.At a final stage of insertion as shown in FIG.", "4C contacting portion 310 is fully formed to the contour of forming tool 900, and has experienced deformation in the forming process but retains spring or resilient characteristics based on the elastic/plastic property of the material of contacting portion 310.Upon completion or partial completion of the forming of contacting portion 310, post 300 is removed from forming tool 900 and may be subsequently installed in the connector 100 or other types of coaxial cable connectors.", "This manner of forming or shaping contacting portion 310 to the contour of forming tool 900 may be useful to aid in handling of post 300 in subsequent manufacturing processes, such as plating for example.", "Additionally, use of this method makes it possible to achieve various configurations of contacting portion 310 formation as illustrated in FIGS.", "5A through 5H.", "FIG.", "5A is a side schematic view of an exemplary embodiment of post 300 where contacting portion 310 is a radially projecting protrusion that completely circumscribes post 300.In this view, contacting portion 310 is formable but has not yet been formed to reflect a contour of coaxial cable connector or forming tool.", "FIG.", "5B is a front schematic view of the post 300 of FIG.", "5.FIG.", "5C is a side schematic view of an exemplary embodiment of post 300 where contacting portion 310 has a multi-cornered configuration.", "Contacting portion 310 may be a protrusion and may, but does not have to be, radially projecting.", "Although in FIG.", "5C contacting portion 310 is shown as tri-cornered, contacting portion 310 can have any number of corner configurations, as non-limiting examples, two, three, four, or more.", "In FIG.", "5C, contacting portion 310 may be formable but has not yet been formed to reflect a contour of coaxial cable connector or forming tool.", "FIG.", "5D is a front schematic view of post 300 of FIG.", "5C.", "FIG.", "5E is a side schematic view of post 300 where contacting portion 310 has a tri-cornered configuration.", "In this view, contacting portion 310 is shown as being formed to a shape in which contacting portion 310 cants or slants toward the front end 305 of post 300.FIG.", "5F is a front schematic view of post 300 of FIG.", "5E.", "FIG.", "5G is a side schematic view of an exemplary embodiment of post 300 where contacting portion 310 has a tri-cornered configuration.", "In this view contacting portion 310 is formed in a manner differing from FIG.", "5E in that indentations 311 in contacting portion 310 result in a segmented or reduced arcuate shape 313.FIG.", "5H is a front schematic view of post 300 of FIG.", "5G.", "It will be apparent to those skilled in the art that contacting portion 310 as illustrated in FIGS.", "2-5H may be integral to and monolithic with post 300.Additionally, contacting portion 310 may have or be any shape, including shapes that may be flush or aligned with other portions of post 300, or may have any number of configurations, as non-limiting examples, configurations ranging from completely circular to multi-cornered geometries, and still perform its function of providing electrical continuity.", "Further, contacting portion 310 may be formable and formed to any shape or in any direction.", "FIG.", "6 is a cross-sectional view of an exemplary embodiment of a coaxial cable connector 110 comprising an integral pin 805, wherein coupler 200 rotates about body 500 instead of post 300 and contacting portion 510 is a protrusion from, integral to and monolithic with body 500 instead of post 300.In this regard, contacting portion 510 may be a unitized portion of body 500.As such, contacting portion 510 may be constructed with body 500 or a portion of body 500 from a single piece of material.", "Coaxial cable connector 110 is configured to accept a coaxial cable.", "Contacting portion 510 may be formed to a contour of coupler 200 as coupler 200 is assembled with body 500 as illustrated in FIG.", "6A.", "FIG.", "6A is a cross-sectional view of an exemplary embodiment of a coaxial cable connector 110 in a state of partial assembly.", "Contacting portion 510 has not been formed to a contour of the coupler 200.Assembling the coupler 200 with the body 500 forms the contacting portion 510 in a rearward facing manner as opposed to a forward facing manner as is illustrated with the contacting portion 310.However, as with contacting portion 310, the material of contacting portion 510 has certain elastic/plastic property which, as contacting portion 510 is formed provides that contacting portion 510 will press against the contour of the coupler 200 and maintain mechanical and electrical contact with coupler 200.Contacting portion 510 provides for electrical continuity from the outer conductor of the coaxial cable to the terminal regardless of the tightness or adequacy of the coupling of the coaxial cable connector 100 to the terminal, and regardless of the tightness of the coaxial cable connector 100 on the terminal in the same way as previously described with respect to contacting portion 310.Additionally or alternatively, contacting portion 310 may be cantilevered or attached at only one end of a segment.", "FIG.", "7 is a cross-sectional view of an exemplary embodiment of a coaxial cable connector 111 comprising an integral pin 805, and a conductive component 400.Coupler 200 rotates about body 500 instead of about a post, which is not present in coaxial cable connector 111.Contacting portion 410 is shown as a protrusion and may be integral to, monolithically with and radially projecting from a conductive component 400 which is press fit into body 500.Contacting portion 410 may be a unitized portion of conductive component 400.As such, the contacting portion 410 may be constructed from a single piece of material with conductive component 400 or a portion of conductive component 400.As with contacting portion 310, the material of contacting portion 410 has certain elastic/plastic property which, as contacting portion 410 is formed provides that contacting portion 410 will press against the contour of the coupler 200 and maintain mechanical and electrical contact with coupler 200 as conductive component 400 inserts in coupler 200 when assembling body 500 with coupler 200 as previously described.", "FIG.", "8 is a cross-sectional view of another exemplary embodiment of the coaxial cable connector 111 comprising an integral pin 805, and a retaining ring 402.The coupler 200 rotates about body 500 instead of a post.", "Contacting portion 410 may be integral with and radially projecting from a retaining ring 402 which fits into a groove formed in body 500.The contacting portion 410 may be a unitized portion of the retaining ring 402.As such, the contacting portion 410 may be constructed from a single piece of material with the retaining ring 402 or a portion of the retaining ring 402.In this regard, FIG.", "8A illustrates front and side views of the retaining ring 402.In FIG.", "8A, contacting portion 410 is shown as three protrusions integral with and radially projecting from retaining ring 402.As discussed above, the material of contacting portion 410 has certain elastic/plastic property which, as contacting portion 410 is formed provides that contacting portion 410 will press against the contour of the coupler 200 and maintain mechanical and electrical contact with coupler 200 as retaining ring 402 inserts in coupler 200 when assembling body 500 with coupler 200 as previously described.", "It will be apparent to those skilled in the art that the contacting portion 410 as illustrated in FIGS.", "6-8A may be integral to the body 500 or may be attached to or be part of another component 400, 402.Additionally, the contacting portion 410 may have or be any shape, including shapes that may be flush or aligned with other portions of the body 500 and/or another component 400, 402, or may have any number of configurations, as non-limiting examples, configurations ranging from completely circular to multi-cornered geometries.", "FIG.", "9 is a cross-sectional view of an embodiment of a coaxial cable connector 112 that is a compression type of connector with no post.", "In other words, having a post-less configuration.", "The coupler 200 rotates about body 500 instead of a post.", "The body 500 comprises contacting portion 510.The contacting portion 510 is integral with the body 500.As such, the contacting portion 510 may be constructed from a single piece of material with the body 500 or a portion of the body 500.The contacting portion 510 forms to a contour of the coupler 200 when the coupler 200 is assembled with the body 500.FIG.", "10 is a cross-sectional view of an embodiment of a coaxial cable connector 113 that is a hex-crimp type connector.", "The coaxial cable connector 113 comprises a coupler 200, a post 300 with a contacting portion 310 and a body 500.The contacting portion 310 is integral to and monolithic with post 300.Contacting portion 310 may be unitized with post 300.As such, contacting portion 310 may be constructed from a single piece of material with post 300 or a portion of post 300.Contacting portion 310 forms to a contour of coupler 200 when coupler 200 is assembled with body 500 and post 300.The coaxial cable connector 113 attaches to a coaxial cable by means radially compressing body 500 with a tool or tools known in the industry.", "FIG.", "11 is an isometric schematic view of post 300 of coaxial cable connector 100 in FIG.", "2 with the contacting portion 310 formed to a position of a contour of a coupler (not shown).", "FIG.", "12 is an isometric cross sectional view of post 300 and coupler 200 of connector 100 in FIG.", "2 illustrated assembled with the post 300.The contacting portion 310 is formed to a contour of the coupler 200.FIG.", "13 is a cross-sectional view of an embodiment of a coaxial cable connector 114 comprising a post 300 and a coupler 200 having a contacting portion 210.Contacting portion 210 is shown as an inwardly directed protrusion.", "Contacting portion 210 is integral to and monolithic with coupler 200 and forms to a contour of post 300 when post 300 assembles with coupler 200.Contacting portion 210 may be unitizedwith coupler 200.As such, contacting portion 210 may be constructed from a single piece of material with coupler 200 or a portion of coupler 200.Contacting portion 210 provides for electrical continuity from the outer conductor of the coaxial cable to the terminal regardless of the tightness or adequacy of the coupling of the coaxial cable connector 114 to the terminal, and regardless of the tightness of coaxial cable connector 114 on the terminal.", "Contacting portion 210 may have or be any shape, including shapes that may be flush or aligned with other portions of coupler 200, or may have and/or be formed to any number of configurations, as non-limiting examples, configurations ranging from completely circular to multi-cornered geometries.", "FIGS.", "14, 15 and 16 are cross-sectional views of embodiments of coaxial cable connectors 115 with a post similar to post 300 comprising a contacting portion 310 as described above such that the contacting portion 310 is shown as outwardly radially projecting, which forms to a contour of the coupler 200 at different locations of the coupler 200.Additionally, the contacting portion 310 may contact the coupler 200 rearward of the lip 215, for example as shown in FIGS.", "15 and 16, which may be at the rearward facing surface 217 of the lip 215, for example as shown in FIG.", "15.FIG.", "17 is a cross-sectional view of an embodiment of a coaxial cable connector 116 with a body 500 comprising a contacting portion 310, wherein the contacting portion 310 is shown as an outwardly directed protrusion from body 500 that forms to the coupler 200.FIG.", "18 is a cross-sectional view of an embodiment of a coaxial cable connector 117 having a post 300 with an integral contacting portion 310 and a coupler 200 with an undercut 231.The contacting portion 310 is shown as a protrusion that forms to the contours of coupler 200 at the position of undercut 231.FIG.", "18A is a cross-sectional view of the coaxial cable connector 117 as shown in FIG.", "18 having a prepared coaxial cable inserted in the coaxial cable connector 117.The body 500 and the post 300 receive the coaxial cable (FIG.", "18A).", "The post 300 at the back end 395 is inserted between an outer conductor and a dielectric layer of the coaxial cable.", "FIG.", "19 is a partial, cross-sectional view of an embodiment of a coaxial cable connector 118 having a post 301 comprising an integral contacting portion 310.The movable post 301 is shown in a forward position with the contacting portion 310 not formed by a contour of the coupler 200.FIG.", "20 is a partial, cross-sectional view of the coaxial cable connector 118 shown in FIG.", "19 with the post 301 in a rearward position and the contacting portion 310 forming to a contour of the coupler 200.RFI shielding within given structures may be complicated when the structure or device comprises moving parts, such as a coaxial cable connector.", "Providing a coaxial cable connector that acts as a Faraday cage to prevent ingress and egress of RF signals can be especially challenging due to the necessary relative movement between connector components required to couple the connector to an equipment port.", "Relative movement of components due to mechanical clearances between the components can result in an ingress or egress path for unwanted RF signal and, further, can disrupt the electrical and mechanical communication between components necessary to provide a reliable ground path.", "To overcome this situation the coaxial cable connector may incorporate one or more circuitous paths that allows necessary relative movement between connector components and still inhibit ingress or egress of RF signal.", "This path, combined with an integral grounding flange of a component that moveably contacts a coupler acts as a rotatable or moveable Faraday cage within the limited space of a RF coaxial connector creating a connector that both shields against RFI and provides electrical ground even when improperly installed.", "In this regard, FIG.", "21 illustrates a coaxial cable connector 119 having front end 105, back end 195, coupler 200, post 300, body 500, compression ring 600 and gripping member 700.Coupler 200 is adapted to couple the coaxial cable connector 119 to a terminal, which includes an equipment connection port.", "Body 500 is assembled with the coupler 200 and post 300.The post 300 is adapted to receive an end of a coaxial cable.", "Coupler 200 at least partially comprises front end 205, back end 295 central passage 210, lip 215, through-bore 220, bore 230 and bore 235.Coupler 200 is preferably made of metal such as brass and plated with a conductive material such as nickel.", "Post 300 at least partially comprises front end 305, back end 395, contacting portion 310, enlarged shoulder 340, collar portion 320, through-bore 325, rearward facing annular surface 330, shoulder 345 and barbed portion 335 proximate back end 395.Post 300 is preferably made of metal such as brass and plated with a conductive material such as tin.", "Contacting portion 310 is integral and monolithic with post 300.Contacting portion 310 provides a stable ground path and protects against the ingress and egress of RF signals.", "Body 500 at least partially comprises front end 505, back end 595, and central passage 525.Body 500 is preferably made of metal such as brass and plated with a conductive material such as nickel.", "Shell 600 at least partially comprises front end 605, back end 695, and central passage 625.Shell 600 is preferably made of metal such as brass and plated with a conductive material such as nickel.", "Gripping member 700 at least partially comprises front end 705, back end 795, and central passage 725.Gripping member 700 is preferably made of a polymer material such as acetal.", "Although, coaxial cable connector 119 in FIG.", "21 is an axial-compression type coaxial connector having post 300, contacting portion 310 may be incorporated in any type of coaxial cable connector.", "Coaxial cable connector 119 is shown in its unattached, uncompressed state, without a coaxial cable inserted therein.", "Coaxial cable connector 119 couples a prepared end of a coaxial cable to a threaded female equipment connection port (not shown in FIG.", "21).", "Coaxial cable connector 119 has a first end 105 and a second end 195.Shell 600 slideably attaches to the coaxial cable connector 119 at back end 595 of body 500.Coupler 200 attaches to coaxial cable connector 119 at back end 295.Coupler 200 may rotatably attach to front end 305 of post 300 while engaging body 300 by means of a press-fit.", "Contacting portion 310 is of monolithic construction with post 300, being formed or constructed in a unitary fashion from a single piece of material with post 300.Post 300 rotatably engages central passage 210 of coupler 200 lip 215.In this way, contacting portion 310 provides an electrically conductive path between post 300, coupler 200 and body 500.This enables an electrically conductive path from the coaxial cable through the coaxial cable connector 119 to the equipment connection port providing an electrical ground and a shield against RF ingress.", "Elimination of separate continuity member 4000 as illustrated in connector 1000 of FIG.", "1 improves DC contact resistance by eliminating mechanical and electrical interfaces between components and further improves DC contact resistance by removing a component made from a material having higher electrical resistance properties.", "An enlarged shoulder 340 at front end 305 extends inside coupler 200.Enlarged shoulder 340 comprises flange 312, contacting portion 310, collar portion 320, rearward facing annular surface 330 and shoulder 345.Collar portion 320 allows coupler 200 to rotate by means of a clearance fit with through bore 220 of coupler 200.Rearward facing annular surface 330 limits forward axial movement of coupler 200 by engaging lip 215.Contacting portion 310 contacts coupler 200 forward of lip 215.Contacting portion 310 may be formed to contactedly fit with the coupler 200 by utilizing coupler 200 to form contacting portion 310 upon assembly of coaxial cable connector 119 components.", "In this manner, contacting portion 310 is secured within coaxial cable connector 119, and establishes mechanical and electrical contact with coupler 200 and, thereby, an electrically conductive path between post 300 and coupler 200.Further, contacting portion 310 remains contactedly fit, in other words in mechanical and electrical contact, with coupler 200 regardless of the tightness of coaxial cable connector 119 on the appliance equipment connection port.", "In this manner, contacting portion 310 is integral to the electrically conductive path established between post 300 and coupler 200 even when the coaxial cable connector 119 is loosened and/or disconnected from the appliance equipment connection port.", "Post 300 has a front end 305 and a back end 395.Back end 395 is adapted to extend into a coaxial cable.", "Proximate back end 395, post 300 has a barbed portion 335 extending radially outwardly from the tubular post 300.With reference to FIG.", "22, there are shown two paths 900, 902, which depict potential RF leakage paths.", "Coaxial cable connector 119 includes structures to increase the attenuation of RF ingress or egress via paths 900, 902.RF leakage may occur via path 900 through coupler 200 back end 295 at the body 500 and between the lip 215 and post 300.However, as shown in FIG.", "23, step 235 and shoulder 345, along with contacting portion 310 and flange 312 form a circuitous path along path 900.The structure of the coupler 200 and post 300 closes off or substantially reduces a potential RF leakage path along path 900, thereby increasing the attenuation of RF ingress or egress signals.", "In this way, coupler 200 and post 500 provide RF shielding such that RF signals external to the coaxial cable connector 119 are attenuated such that the integrity of an electrical signal transmitted through coaxial cable connector 119 is maintained regardless of the tightness of the coupling of the connector to equipment connection port 904.With reference again to FIG.", "22, RF leakage via path 902 may be possible along threaded portion of coupler 200 to equipment connection port 904.This is particularly true when the coaxial cable connector 119 is in a dynamic condition such as during vibration or other type of externally induced motion.", "Under these conditions electrical ground can be lost and an RF ingress path opened when the threads 204 of the coupler 200 and the threads 906 of the equipment connection port 904 become coaxially aligned reducing or eliminating physical contact between the coupler 200 and the equipment connection port 904.By modifying the form of the coupler 200 threads 204 the tendency of the coupler 200 to equipment connection port 904 to lose ground contact and open an RF ingress path via path 902 is mitigated, thereby increasing the attenuation of RF ingress or egress signals.", "The structure of the threads 204 of the coupler 200 may involve aspects including, but are not limited to, pitch diameter of the thread, major diameter of the thread, minor diameter of the thread, thread pitch angle “θ”, thread pitch depth, and thread crest width and thread root radii.", "Typically, the pitch angle “θ” of thread 204 of coupler 200 is designed to match, as much as possible, the pitch angle “θ” of thread 906 of equipment connection port 904.As shown in FIG.", "24, pitch angle “θ” may be different than pitch angle “θ” to reduce interfacial gap between thread 204 of coupler 200 and thread 906 of equipment connection port 904.In this way, the threaded portion of the coupler 200 traverses a shorter distance before contacting the threaded portion of the equipment connection port 904 closing off or substantially reducing a potential RF leakage path along path 902.Typically, thread 906 angle “φ” of the equipment connection port 904 is set at 60 degrees.", "As a non-limiting example, instead of designing coupler 200 with threads 204 of angle “θ”, angle “θ” may be set at about 62 degrees which may provide the reduced interfacial gap as discussed above.", "In this way, coupler 200 and post 500 provide RF shielding such that RF signals external to the coaxial cable connector 119 are attenuated such that the integrity of an electrical signal transmitted through coaxial cable connector 119 is maintained regardless of the tightness of the coupling of the connector to equipment connection port 904.Typically, RF signal leakage is measured by the amount of signal loss expressed in decibel (“dB”).", "Therefore, “dB” relates to how effectively RF shielding is attenuating RF signals.", "In this manner, RF signal ingress into a coaxial cable connector 119 or egress out from a coaxial cable connector 119 may be determined, and, thereby, the ability of the RF shielding of a coaxial cable connector 119 to attenuate RF signals external to the coaxial cable connector 119.Accordingly, the lower the value of “dB” the more effective the attenuation.", "As an example, a measurement RF shielding of −20 dB would indicate that the RF shield attenuates the RF signal by 20 dB as compared at the transmission source.", "For purposes herein, RF signals external to the coaxial cable connector 119 include either or both of RF signal ingress into a coaxial cable connector 119 or egress out from a coaxial cable connector 119.Referring now to FIG.", "25, illustrates comparative RF shielding effectiveness in “dB” of coaxial cable connector 119 over a range of 0-1000 megahertz (“MHz”).", "The coupling 200 was finger tightened on the equipment connection port 904 and then loosened two full turns.", "As illustrated in FIG.", "25, the RF shielding in “dB” for coaxial cable connector 119 for all frequencies tested indicated that the RF signal was attenuated by more than 50 dB.", "Additionally, the effectiveness of RF signal shielding may be determined by measuring transfer impedance of the coaxial cable connector.", "Transfer impedance is the ratio of the longitudinal voltage developed on the secondary side of a RF shield to the current flowing in the RF shield.", "If the shielding effectiveness of a point leakage source is known, the equivalent transfer impedance value can be calculated using the following calculation: SE=20 log Ztotal−45.76 (dB) Accordingly, using this calculation the average equivalent transfer impedance of the coaxial cable connector 119 is about 0.24 ohms.", "As discussed above, electrical continuity shall mean DC contact resistance from the outer conductor of the coaxial cable to the equipment port of less than about 3000 milliohms.", "In addition to increasing the attenuation of RF signals by closing off or reducing the RF leakage via paths 900, 902, the DC contact resistance may be substantially reduced.", "As a non-limiting example, the DC contact resistance may be less than about 100 milliohms, and preferably less than 50 milliohms, and more preferably less than 30 milliohms, and still more preferably less than 10 milliohms.", "It should be understood that while the invention has been described in detail with respect to various exemplary embodiments thereof, it should not be considered limited to such, as numerous modifications are possible without departing from the broad scope of the appended claims.", "It is intended that the embodiments cover the modifications and variations of the embodiments provided they come within the scope of the appended claims and their equivalents.", "Although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation." ] ]
Patent_15874306
[ [ "METHOD OF SEPARATING ELECTRONIC DEVICES HAVING A BACK LAYER AND APPARATUS", "A method of singulating a wafer includes providing a wafer having a plurality of die formed as part of the wafer and separated from each other by spaces, wherein the wafer has first and second opposing major surfaces, and wherein a layer of material is formed along the second major surface.", "The method includes placing the wafer onto a carrier substrate.", "The method includes singulating the wafer through the spaces to form singulation lines after the placing the wafer on the carrier substrate, wherein singulating comprises stopping in proximity to the layer of material.", "The method includes applying a pressure to the entire wafer thereby separating the layer of material in the singulation lines, wherein applying the pressure comprises using a fluid.", "The method provide a way to batch separate layers of material disposed on wafers after singulating the wafers." ], [ "1.An apparatus for batch singulating a layer of material on a substrate comprising: a chamber having a sidewall structure and a chamber surface, wherein the chamber surface is configured for supporting a substrate having a layer of material disposed on a major surface of the substrate; a pressure transfer vessel contained within the sidewall structure; and a structure associated with the chamber, wherein the structure and the pressure transfer vessel are adapted to apply pressure to batch singulate at least portions of the layer of material.", "2.The apparatus of claim 1, wherein: the pressure transfer vessel is configured to hold a fluid; and the chamber surface is configured for supporting a substrate attached to a carrier substrate.", "3.The apparatus of claim 2, wherein the chamber surface is configured for supporting the carrier substrate comprising a carrier tape that is attached to a frame.", "4.The apparatus of claim 1 further comprising a pressure plate interposed between the pressure transfer vessel and the chamber surface.", "5.The apparatus of claim 1, wherein: the structure comprises a compression structure movably associated within the chamber, wherein the pressure transfer vessel is interposed between the chamber surface and the compression structure; and the pressure transfer vessel is configured to have a width larger than a diameter of the substrate.", "6.The apparatus of claim 1, wherein the chamber surface is configured for supporting the substrate having a plurality of die formed as part of the substrate and separated from each other by singulation lines, wherein the singulation lines terminate adjacent to the layer of material.", "7.A method of singulating a wafer comprising: providing a wafer having a plurality of die formed as part of the wafer and separated from each other by spaces, wherein the wafer has first and second opposing major surfaces, and wherein a layer of material is formed along the second major surface; placing the wafer onto a carrier substrate; singulating the wafer through the spaces to form singulation lines after the placing the wafer on the carrier substrate, wherein singulating comprises stopping in proximity to the layer of material; and applying a pressure to the entire wafer thereby separating the layer of material in the singulation lines, wherein applying the pressure comprises using a fluid.", "8.The method of claim 7, wherein applying the pressure comprises applying the pressure through the carrier substrate.", "9.The method of claim 7, wherein: applying the pressure comprises: placing the wafer and carrier substrate within a chamber, the chamber at least partially enclosing a pressure transfer vessel, wherein the pressure transfer vessel contains the fluid; and moving a compression structure against the pressure transfer vessel thereby applying a pressure substantially uniformly along the second major surface to separate the layer of material in the singulation lines.", "10.The method of claim 9, wherein: placing the wafer and the carrier substrate within the chamber comprises placing the pressure transfer vessel against the carrier substrate such that the carrier substrate is between the pressure transfer vessel and the wafer; and wherein the pressure transfer vessel has a width that exceeds that of the wafer.", "11.The method of claim 10 further comprising placing a pressure plate between the pressure transfer vessel and the carrier substrate.", "12.The method of claim 7, wherein: providing the wafer comprises providing a semiconductor wafer where the layer of material comprises a conductive material.", "13.The method of claim 7 further comprising placing a protective film proximate to the first major surface of the wafer before applying the pressure.", "14.The method of claim 7, wherein applying the pressure comprises extruding portions of the carrier substrate into the singulation lines to separate the layer of material, and wherein the portions of the separated layer of material remain on the carrier substrate after separating the layer of material.", "15.The method of claim 7, further comprising heating one or more of the wafer and the carrier substrate during at least a portion of the step of applying the pressure.", "16.A method of singulating a layer of material on a singulated substrate comprising: providing a semiconductor substrate that is attached to a carrier substrate, the semiconductor substrate having a plurality of die formed as part of the semiconductor substrate and separated from each other by singulation lines comprising gaps, wherein the semiconductor substrate has first and second opposing major surfaces, and wherein the layer of material is disposed atop the second major surface, and wherein the singulation lines terminate adjacent to the conductive layer; and using a fluid to simultaneously apply a pressure to the entire semiconductor substrate thereby separating the layer of material in the singulation lines.", "17.The method of claim 16, wherein using the fluid comprises: placing the semiconductor substrate and the carrier substrate within a chamber, the chamber at least partially enclosing a pressure transfer vessel that contains the fluid; and applying a pressure to the pressure transfer vessel thereby applying a transferred pressure to the layer of material to separate the layer of material in the singulation lines.", "18.A method for batch singulating a semiconductor wafer comprising: providing the semiconductor wafer having a plurality of die formed on the semiconductor wafer and separated from each other by spaces, wherein the semiconductor wafer has first and second opposing major surfaces, and wherein a layer of material is formed along the second major surface; placing the semiconductor wafer onto a carrier substrate, wherein the layer of material is adjacent the carrier substrate; after placing the semiconductor wafer onto the carrier substrate, etching the semiconductor wafer through the spaces to form singulation lines comprising gaps and to expose portions of the layer of material in the singulation lines; and applying a pressure to the entire semiconductor wafer through the carrier substrate to separate the layer of material in the singulation lines.", "19.The method of claim 18, wherein applying the pressure comprises applying the pressure using a fluid.", "20.The method of claim 18, further comprising heating one or more of the semiconductor wafer and the carrier substrate during at least a portion of the step of applying the pressure." ], [ "<SOH> BACKGROUND <EOH>The present invention relates, in general, to electronics and, more particularly, to methods for forming electronic devices such as semiconductor dies.", "In the past, the semiconductor industry utilized various methods and equipment to singulate individual semiconductor die from a semiconductor wafer on which the die was manufactured.", "Typically, a technique called scribing or dicing was used to either partially or fully cut through the wafer with a diamond cutting wheel along scribe grids or singulation lines that were formed on the wafer between the individual die.", "To allow for the alignment and the width of the dicing wheel each scribe grid usually had a large width, generally about one hundred fifty (150) microns, which consumed a large portion of the semiconductor wafer.", "Additionally, the time required to scribe each singulation line on the semiconductor wafer could take over one hour or more.", "This time reduced the throughput and manufacturing capacity of a production facility.", "Other methods, which have included thermal laser separation (TLS), laser ablation dicing, and plasma dicing, have been explored as alternatives to scribing.", "Plasma dicing is a promising process compared to scribing and other alternative processes because it supports narrower scribe lines, has increased throughput, and can singulate die in varied and flexible patterns.", "However, plasma dicing has had manufacturing implementation challenges.", "Such challenges have included non-compatibility with wafer backside layers, such as back metal layers, because the etch process has been unable to effectively remove or separate the backside layers from the singulation lines.", "Removing or separating the backside layers from the scribe lines is necessary to facilitate subsequent processing, such as pick-and-place and assembly processes.", "Accordingly, it is desirable to have a method of singulating die from a semiconductor wafer that removes or separates the backside layers from within the singulation lines.", "It would be beneficial for the method to be cost effective and to minimize any damage to or contamination of the separated die." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 illustrates a reduced plan view of an embodiment of a wafer in accordance with the present invention; FIG.", "2 illustrates a cross-sectional view of the wafer of FIG.", "1 mounted to a carrier substrate in accordance with an embodiment of the present invention; FIG.", "3 illustrates a top view of the embodiment of FIG.", "2 ; FIGS.", "4-5 illustrate partial cross-sectional views of the wafer of FIG.", "1 at various stages in a process of singulating die from the wafer in accordance with an embodiment of the present invention; FIG.", "6 illustrates a cross-sectional view of the wafer of FIG.", "1 at a subsequent stage of singulation in accordance with an embodiment of the present invention; FIG.", "7 illustrates an enlarged partial cross-sectional view of the embodiment of FIG.", "6 in accordance with reference portion 7 - 7 ; FIG.", "8 illustrates the wafer of FIG.", "1 after singulation and at a further stage of manufacture in accordance with an embodiment of the present invention; and FIG.", "9 illustrates a flow chart of a batch singulation method in accordance with an embodiment of the present invention.", "detailed-description description=\"Detailed Description\" end=\"lead\"?", "For simplicity and clarity of the illustration, elements in the figures are not necessarily drawn to scale, and the same reference numbers in different figures denote the same elements.", "Additionally, descriptions and details of well-known steps and elements are omitted for simplicity of the description.", "For clarity of the drawings, certain regions of device structures, such as doped regions or dielectric regions, may be illustrated as having generally straight line edges and precise angular corners.", "However, those skilled in the art understand that, due to the diffusion and activation of dopants or formation of layers, the edges of such regions generally may not be straight lines and that the corners may not be precise angles.", "The terms first, second, third and the like in the claims or/and in the Detailed Description of the Drawings, as used in a portion of a name of an element are used for distinguishing between similar elements and not necessarily for describing a sequence, either temporally, spatially, in ranking or in any other manner It is to be understood that the terms so used are interchangeable under appropriate circumstances and that the embodiments described herein are capable of operation in other sequences than described or illustrated herein.", "Furthermore, the term “major surface” when used in conjunction with a semiconductor region, wafer, or substrate means the surface of the semiconductor region, wafer, or substrate that forms an interface with another material, such as a dielectric, an insulator, a conductor, or a polycrystalline semiconductor.", "The major surface can have a topography that changes in the x, y and z directions.", "Also, it is to be understood that where it is stated herein that one layer or region is formed on or disposed on a second layer or another region, the first layer may be formed or disposed directly on the second layer or there may be intervening layers between the first layer and the second layer.", "In addition, as used herein, the term formed on is used with the same meaning as located on or disposed on and is not meant to be limiting regarding any particular fabrication process." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS The present application is a divisional application of co-pending U.S. patent application Ser.", "No.", "15/403,676, filed on Jan. 11, 2017, which is a continuation application of U.S. patent application Ser.", "No.", "15/185,208, filed on Jun.", "17, 2016 and issued as U.S. Pat.", "No.", "9,589,844 on Mar.", "7, 2017, which is a continuation of U.S. patent application Ser.", "No.", "14/222,464, filed on Mar.", "21, 2014 and issued as U.S. Pat.", "No.", "9,418,894 on Aug. 16, 2016, which are hereby incorporated by reference, and priority thereto is hereby claimed.", "BACKGROUND The present invention relates, in general, to electronics and, more particularly, to methods for forming electronic devices such as semiconductor dies.", "In the past, the semiconductor industry utilized various methods and equipment to singulate individual semiconductor die from a semiconductor wafer on which the die was manufactured.", "Typically, a technique called scribing or dicing was used to either partially or fully cut through the wafer with a diamond cutting wheel along scribe grids or singulation lines that were formed on the wafer between the individual die.", "To allow for the alignment and the width of the dicing wheel each scribe grid usually had a large width, generally about one hundred fifty (150) microns, which consumed a large portion of the semiconductor wafer.", "Additionally, the time required to scribe each singulation line on the semiconductor wafer could take over one hour or more.", "This time reduced the throughput and manufacturing capacity of a production facility.", "Other methods, which have included thermal laser separation (TLS), laser ablation dicing, and plasma dicing, have been explored as alternatives to scribing.", "Plasma dicing is a promising process compared to scribing and other alternative processes because it supports narrower scribe lines, has increased throughput, and can singulate die in varied and flexible patterns.", "However, plasma dicing has had manufacturing implementation challenges.", "Such challenges have included non-compatibility with wafer backside layers, such as back metal layers, because the etch process has been unable to effectively remove or separate the backside layers from the singulation lines.", "Removing or separating the backside layers from the scribe lines is necessary to facilitate subsequent processing, such as pick-and-place and assembly processes.", "Accordingly, it is desirable to have a method of singulating die from a semiconductor wafer that removes or separates the backside layers from within the singulation lines.", "It would be beneficial for the method to be cost effective and to minimize any damage to or contamination of the separated die.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a reduced plan view of an embodiment of a wafer in accordance with the present invention; FIG.", "2 illustrates a cross-sectional view of the wafer of FIG.", "1 mounted to a carrier substrate in accordance with an embodiment of the present invention; FIG.", "3 illustrates a top view of the embodiment of FIG.", "2; FIGS.", "4-5 illustrate partial cross-sectional views of the wafer of FIG.", "1 at various stages in a process of singulating die from the wafer in accordance with an embodiment of the present invention; FIG.", "6 illustrates a cross-sectional view of the wafer of FIG.", "1 at a subsequent stage of singulation in accordance with an embodiment of the present invention; FIG.", "7 illustrates an enlarged partial cross-sectional view of the embodiment of FIG.", "6 in accordance with reference portion 7-7; FIG.", "8 illustrates the wafer of FIG.", "1 after singulation and at a further stage of manufacture in accordance with an embodiment of the present invention; and FIG.", "9 illustrates a flow chart of a batch singulation method in accordance with an embodiment of the present invention.", "For simplicity and clarity of the illustration, elements in the figures are not necessarily drawn to scale, and the same reference numbers in different figures denote the same elements.", "Additionally, descriptions and details of well-known steps and elements are omitted for simplicity of the description.", "For clarity of the drawings, certain regions of device structures, such as doped regions or dielectric regions, may be illustrated as having generally straight line edges and precise angular corners.", "However, those skilled in the art understand that, due to the diffusion and activation of dopants or formation of layers, the edges of such regions generally may not be straight lines and that the corners may not be precise angles.", "The terms first, second, third and the like in the claims or/and in the Detailed Description of the Drawings, as used in a portion of a name of an element are used for distinguishing between similar elements and not necessarily for describing a sequence, either temporally, spatially, in ranking or in any other manner It is to be understood that the terms so used are interchangeable under appropriate circumstances and that the embodiments described herein are capable of operation in other sequences than described or illustrated herein.", "Furthermore, the term “major surface” when used in conjunction with a semiconductor region, wafer, or substrate means the surface of the semiconductor region, wafer, or substrate that forms an interface with another material, such as a dielectric, an insulator, a conductor, or a polycrystalline semiconductor.", "The major surface can have a topography that changes in the x, y and z directions.", "Also, it is to be understood that where it is stated herein that one layer or region is formed on or disposed on a second layer or another region, the first layer may be formed or disposed directly on the second layer or there may be intervening layers between the first layer and the second layer.", "In addition, as used herein, the term formed on is used with the same meaning as located on or disposed on and is not meant to be limiting regarding any particular fabrication process.", "DETAILED DESCRIPTION OF THE DRAWINGS FIG.", "1 is a reduced plan view that graphically illustrates a wafer 10 at a later step in fabrication.", "In one embodiment, wafer 10 can be a semiconductor substrate.", "Wafer 10 includes a plurality of semiconductor die, such as die 12, 14, 16, and 18, that are formed on or as part of semiconductor wafer 10.Die 12, 14, 16, and 18 are spaced apart from each other on wafer 10 by spaces in which singulation lines are to be formed or defined, such as scribe lines or singulation lines 13, 15, 17, and 19.As is well known in the art, all of the semiconductor die on wafer 10 generally are separated from each other on all sides by areas or spaces where scribe lines or singulation lines, such as singulation lines 13, 15, 17, and 19 are to be formed.", "Die 12, 14, 16, and 18 can be any kind of electronic device including semiconductor devices such as, diodes, transistors, discrete devices, integrated circuits, sensor devices, optical devices, or other devices known to one of ordinary skill in the art.", "In one embodiment, wafer 10 has completed wafer processing including the formation of a backside layer described later.", "FIG.", "2 illustrates an enlarged cross-sectional view of wafer 10 at an early step in a die singulation method in accordance with an embodiment.", "In one embodiment, wafer 10 is attached to a carrier substrate, transfer tape, or carrier tape 30 that facilitates supporting the plurality of die on wafer 10 after the die are singulated.", "Such carrier tapes are well known to those of skill in the art.", "In one embodiment, carrier tape 30 can be attached to a frame 40, which can include frame portions or portions 401 and 402.In one embodiment, frame 40 is made of a rigid material, such as stainless steel.", "As illustrated, carrier tape 30 can be attached to surface 4010 of frame portion 401 and to surface 4020 of frame portion 402 using, for example, the adhesive side of carrier tape 30.In the cross-section illustrated, wafer 10 can include a bulk substrate 11, such as a silicon substrate, which can include opposing major surfaces 21 and 22.In other embodiments, bulk substrate 11 can comprise other semiconductor materials such as heterojunction semiconductor materials or substrate 11 can be an insulating material such as ceramic materials.", "In one embodiment, contact pads 24 can be formed along, in, on, or above portions of major surface 21 to provide for electrical contact between structures formed within substrate 11 and next levels of assembly or external elements.", "For example, contact pads 24 can be formed to receive bonding wires or clips that subsequently may be attached to contact pads 24, or contact pads 24 can be formed to receive a solder ball, bump or other type of attachment structure.", "Contact pads 24 generally can be a metal or other conductive material.", "Typically, a dielectric material 26 such as, a blanket deposited dielectric layer can be formed on or overlying major surface 21 to function as a passivation layer for wafer 10.In one embodiment, dielectric material 26 can be a material that etches at a slower rate than that of substrate 11.In one embodiment, dielectric material 26 can be a silicon oxide, silicon nitride, or polyimide when substrate 11 is silicon.", "It should also be noted that a separate polymer protective layer, such as a patterned protective layer, can be used to protect the areas not intended to be etched during subsequent processing.", "In one embodiment, the patterned protective layer can be a patterned photoresist layer.", "An example of such a protective layer is noted as element 35 in FIG.", "4 described later.", "In one embodiment, openings can be formed in dielectric material 26 (and other dielectric layers that can be formed above or below dielectric material 26) to expose underlying surfaces of contact pads 24 and surfaces of substrate 11 where singulation lines 13, 15, 17, and 19 are to be formed.", "In one embodiment, the patterned photoresist layer describes previously can be used to form the openings with an etch process.", "As illustrated in FIG.", "2 and in accordance with the present embodiment, wafer 10 further includes a layer of material 28 formed on or overlying major surface 22 of wafer 10.In one embodiment, layer 28 can be a conductive back metal layer.", "Layer 28 can be any suitable conductive material appropriate for electronic technology.", "In one embodiment, layer 28 can be a multi-layer metal system such as, titanium/nickel/silver, titanium/nickel/silver/tungsten, chrome/nickel/gold, copper, copper alloys, gold, or other materials known to those skilled in the art.", "In some embodiments, layer 28 is greater than about one micron in thickness.", "In other embodiments, layer 28 is greater than about two microns in thickness.", "In still other embodiments, layer 28 is greater than about three microns in thickness.", "In another embodiment, layer 28 can be a wafer backside coating (WBC) film, such as a die-attach coating or film.", "In one embodiment, layer 28 can be formed having or provided with recesses, gaps, spaces, or channels between at least some adjacent die.", "In a further embodiment, the gaps are substantially aligned with corresponding spaces on the opposite side of wafer 10 where singulation lines 13, 15, 17, 19 will be formed.", "In another embodiment, layer 28 is separated from the edges of least some of the die.", "FIG.", "3 illustrates a top view of wafer 10 in accordance with the cross-sectional view of FIG.", "2 after wafer 10 is be mounted on carrier tape 30 with layer 28 against carrier tape 30.In one embodiment, carrier tape 30 is mounted to frame 40.As illustrated in FIG.", "3, frame 40 can be configured with alignment portions or notches to better assist placing frame 40 into processing equipment such as the equipment described herein.", "FIG.", "4 illustrates an enlarged cross-sectional view of wafer 10 at a subsequent step during a singulation process in accordance with the present embodiment.", "In FIG.", "4, a plasma or dry etch singulation process is illustrated.", "It is understood that other singulation processes can be used.", "In one embodiment, wafer 10 mounted on carrier tape or film 30 is then placed within an etch apparatus 300, such as a plasma etch apparatus.", "In one embodiment, substrate 11 can be etched through the openings to form or define singulation lines or openings 13, 15, 17, and 19 extending from major surface 21.The etching process can be performed using a chemistry (generally represented as arrows 31) that selectively etches silicon at a much higher rate than that of dielectrics and/or metals.", "In one embodiment, wafer 10 can be etched using a process commonly referred to as the Bosch process.", "In one embodiment, wafer 10 can be etched using the Bosch process in a deep reactive ion etch system.", "In one embodiment, the width of singulation lines 13, 15, 17, and 19 can be from about five microns to about twenty microns.", "Such a width is sufficient to ensure that the openings that form singulation lines 13, 15, 17, and 19 can be formed completely through substrate 11 stopping proximate to or on layer 28 because of the etch selectivity as generally illustrated in FIG.", "5.In one embodiment, layer 28 can be used as a stop layer for the plasma etch singulation process.", "In one embodiment, singulation lines 13, 15, 17, and 19 can be formed in about five to about thirty minutes using the Bosch process.", "A suitable etch apparatus is available from Plasma-Therm of St. Petersburg, Fla., U.S.A.", "FIG.", "6 illustrates a cross-sectional view of a back layer separation apparatus 60 configured to hold wafer 10 including frame 40 and carrier tape 30.In one embodiment, separation apparatus 60 can be configured to process a single wafer and to provide a back layer separation process where layer 28 on wafer 10 is separated substantially at the same time (that is, batch separated) compared to other processes that separate only a localized portion of layer 28 at a time.", "In other embodiments, separation apparatus 60 can be configured to process multiple wafers each in a batch configuration.", "Apparatus 60 can include a compression chamber 62 sized to accommodate wafer 10 and frame 40 depending upon the sizes of such structures.", "In one embodiment, compression chamber 62 is bounded on all sides by a plurality of generally vertical sidewalls 63 that extend generally upward from a lower chamber wall or surface 67.Sidewalls 63 can be attached to lower chamber wall 67 using any suitable attachment devices capable of maintaining pressure with compression chamber 62.Compression chamber 62 further includes an upper chamber wall or surface 68, which can include an opening 69 to accommodate a compression or pressure plate 71 or to provide an entrance for a non-compressible fluid.", "Compression chamber 62 and can be any suitable shape appropriate for processing wafer 10 and frame 40 or other holding structures.", "Compression plate 71 is movably associated or attached within compression chamber 62 and adapted to apply a controlled and substantially uniform pressure to wafer 10 through a pressure transfer vessel 73 containing a fluid 74.In one embodiment, vessel 73 can be a fluid filled bladder that is oriented between wafer 10 and compression plate 71.In one embodiment, vessel 73 comprises a cross-linked polymer material that exhibits high elastic deformation, such as a rubber or other materials as known to those of ordinary skill in the art.", "In one embodiment, vessel 73 is a static pressure balloon.", "In one embodiment, fluid 74 can be water.", "In one embodiment, fluid 74 can be water that is anaerobic (that is, water having low dissolved oxygen content or that has been deoxygenated).", "In some embodiments, fluid 74 can be heated above room temperature.", "In some embodiments, fluid 74 can be heated to a temperature in range from about 35 degrees Celsius to about 65 degrees Celsius.", "In one embodiment, fluid 74 can be heated to a temperature in range from about 45 degrees Celsius to about 55 degrees Celsius.", "In other embodiments, fluid 74 can be a fluid having a higher viscosity than water.", "In some embodiments, fluid 74 can be liquid-crystalline material.", "In still other embodiments, vessel 73 can be filled with a solid material, such as synthetic microspheres, carbon nanotubes, graphene, or other solid or solid-like materials that can impart or transfer pressure from compression plate 71 to carrier tape 30 without damaging wafer 10.In some embodiments, vessel 73 can be filled with a gas.", "In accordance with the present embodiment and illustrated in FIG.", "6, vessel 73 has a horizontal width proximate to wafer 10 that is larger than the horizontal width or diameter of wafer 10 to facilitate batch or near simultaneous singulation or separation of layer 28 in scribe lines 13, 15, 17, and 19 of wafer 10.That is, vessel 73 is configured or adapted to apply a pressure substantially uniformly along or across all of layer 28 and wafer 10 to provide batch separation of layer 28 in the scribe lines.", "In an optional embodiment, a pressure plate 77 can be detachably placed in between vessel 73 and carrier tape 30 above or in spaced relationship with wafer 10 and layer 28.In one embodiment, pressure plate 77 can be a low-alloy, medium-carbon steel or high-carbon steel material with high yield strength, such as spring steel.", "Such a material allows pressure plate 77 to return to its original shape despite any significant bending.", "In one embodiment, pressure plate 77 can be a generally flat plate where the major surfaces lie in substantially parallel horizontal planes.", "In other embodiments, pressure plate 77 can have a lower surface (that is, the surface adjoining carrier tape 30) configured to first apply pressure to the outer portions of wafer 10 before or slightly before pressure applied to the more central portion of wafer 10.For example, in one embodiment pressure plate 77 can have a slightly concave major surface adjoining carrier tape 30 without pressure applied with vessel 73.In another embodiment, pressure plate 77 can have a slightly raised ridge, for example, in the shape or form of a ring around an outer periphery of pressure plate 77.In some embodiments, a protective film or protective pad 83 is placed between wafer 10 and lower chamber wall 67 to protect and/or cushion wafer 10 during the separation of back layer 28.In one embodiment, protective film 83 is a non-adhesive film or a low adhesive film where the adhesive strength is selected so as to minimize the occurrence of individual die being removed from carrier tape 30 after separation of back layer 28 has occurred.", "In other embodiments, protective film 83 can have a high adhesive strength (that is, higher than the adhesive strength of carrier tape 30) if it is desired to have the separated die adhere to protective film 83, for example, for additional processing to the back side of wafer 10.In some embodiments, a controlled downward pressure (represented by arrows 701 and 702) is applied through compression plate 71 using, for example, a stepper motor driving a threaded shaft attached to compression plate 71.In other embodiments, compression plate 71 can be adjusted using hydraulic or pneumatic techniques.", "In some embodiments, compression plate 71 can be adjusted manually.", "It is understood that apparatus 60 may include other sealing devices, fluid heating and delivery devices, and measurement and control systems that are not illustrated for the ease of understanding embodiments of the present invention.", "Suitable apparatus that can be configured in accordance with the description provided herein are available from Instron® of Norwood, Mass., U.S.A. and Geocomp Corporation of St. Johns, N.Y., U.S.A.", "FIG.", "7 illustrates an enlarged partial cross-sectional view of a portion of apparatus 60 and wafer 10 of FIG.", "6 along reference portion 7-7.In FIG.", "7, carrier tape 30 is enlarged to show both a singulation film portion 301 and an adhesive film portion 302 between singulation film portion 301 and layer 28 on wafer 10.In some embodiments, singulation film portion 301 can have a thickness from about 70 microns to about 90 microns and adhesive film portion 302 can have thickness from about 20 microns to about 40 microns.", "In accordance with some embodiments, pressure applied from compression plate 71 is transferred and applied through vessel 73 to optional pressure transfer plate 77 to carrier tape 30 as generally represented by arrows 701, 702, and 703.The downward force applied to carrier tape 30 extrudes adhesive film portion 30 in scribe lines 13, 15, 17, and 19 between die 12, 14, 16, and 18 to separate away or singulate portions of layer 28 in the scribe lines as generally illustrated in FIG.", "7.In some embodiments, a downward force can be in the range from about 700 KPa to 1400 KPa.", "In other embodiments, downward force can be in the range from about 1400 KPa to 3500 KPa.", "One advantage of the present method is that it provides a batch singulation of layer 28 compared to previous processes that provide localized singulation of layer 28.The present embodiments thus reduce manufacturing cycle time.", "Another advantage is that metal separates cleanly and self-aligned to the die edge and further, remaining material of layer 28 between die will remain on the tape after the die are removed with no need to flip the tape to expose and remove or separate the metal.", "FIG.", "8 illustrates a cross-sectional view of wafer 10 at a further stage of manufacturing.", "In one embodiment, die 12, 14, 16, and 18 can be removed from carrier tape 30 as part of a further assembly process using, for example, a pick-and-place apparatus 81 as generally illustrated in FIG.", "8.As illustrated in FIG.", "8 portions 280 separated from layer 28 remain on carrier tape 30.In one embodiment, die 12, 14, 16, and 18 can be attached to conductive lead frames or substrates, electrically connected to leads for traces, and encapsulated with a plastic molding compound.", "In one embodiment, carrier tape 30 can be exposed to a UV light source prior to the pick-and-place step to reduce the adhesiveness of carrier tape 30.FIG.", "9 illustrates a flow chart for batch singulating backside material in accordance with an embodiment.", "In step 900, wafer 10 can be placed onto a carrier film, such as carrier tape 30, as generally illustrated in FIG.", "2.In accordance with the present embodiment, wafer 10 includes back layer, such as layer of material 28.In some embodiments, layer 28 is a conductive metal material.", "In other embodiments, layer 28 can be a Wafer Back Coat (WBC) film, such as a die-attached coating or film.", "In step 901, material, such as semiconductor material, is removed from scribe lines 13, 15, 17, and 19.Semiconductor material can be removed to expose layer 28 in scribe lines 13, 15, 17, and 19, or small amount of material can be left in scribe lines 13, 15, 17, and 19.Stated another way, a sufficient amount of material is removed so that layer 28 can be effectively separated in scribe lines 13, 15, 17, and 19 in a subsequent step.", "In step 902, wafer 10 on carrier tape 30 is placed in apparatus 60 as described with FIG.", "6.In one embodiment, wafer 10 is placed front side or device side down with layer 28 and carrier tape 30 facing upward.", "In one embodiment, pressure plate 77 can be placed adjacent to carrier tape 30 proximate to wafer 10 and layer 28.A fluid filled vessel, such as vessel 73, can then placed proximate to pressure plate 77 as generally illustrated in FIGS.", "6 and 7.In one embodiment, the fluid filled vessel is filled with deoxygenated water heated to temperature from about 35 degrees Celsius to about 65 degrees Celsius.", "In step 903, a pressure is applied to the fluid filled vessel using, for example, a moveable compression plate 71 as described in conjunction with FIG.", "6.In one embodiment, a pressure range from about 500 KPa to 5000 KPa can be used.", "In one embodiment, the pressure applied to the fluid filled vessel causes portions of the carrier film, for example, adhesive film portion 302, to extrude into the scribe lines, such as scribe lines 13, 15, 17, 19, which batch singulates or simultaneously separates all or major portions of layer 28 from the scribe lines.", "In other embodiments, step 903 can applied multiple times (that is, more than once on the same wafer) with pressure applied, then removed, then re-applied.", "In some embodiments, the re-applied pressure can be greater than the previously applied pressure.", "In other embodiments, the re-applied pressure can be less than the previously applied pressure.", "In still other embodiments, compression plate 71 can be slightly tilted and rotated to apply additional pressure around the edge regions of wafer 10.In further embodiments, compression plate 71 can be rocked back and forth in multiple directions.", "From all of the foregoing, one skilled in the art can determine that, according to one embodiment, a method of singulating a wafer (for example, element 10) comprises providing a wafer (for example, element 10) having a plurality of die (for example, elements 12, 14, 16, 18) formed on the wafer and separated from each other by spaces, wherein the wafer has first and second opposing major surfaces (for example, elements 21, 22), and wherein a layer of material (for example, element 28) is formed along the second major surface.", "The method comprises placing the wafer onto a carrier substrate (for example, element 30).", "The method comprises singulating the wafer through the spaces to form singulation lines (for example, elements 13, 15, 17, 19), wherein singulating comprises stopping in proximity to the layer of material.", "The method comprises applying a pressure substantially uniformly along the second major surface to separate the layer of material in the singulation lines.", "In one embodiment of the foregoing method, after applying the pressure portions (for example, element 280) of the separated layer of material remain on the carrier substrate.", "In another embodiment, applying the pressure can include applying the pressure through the carrier substrate with a fluid filled vessel (for example, element 73) and the fluid filled vessel has a width that exceeds that of the wafer.", "In a further embodiment, the fluid filled vessel can contain water.", "In a still further embodiment, the water can be deoxygenated.", "In another embodiment, the method can further include placing a pressure plate between the fluid filled vessel and the carrier substrate, and wherein providing the wafer can comprise providing a semiconductor wafer where the layer of material comprises a conductive material, placing the wafer onto the carrier substrate can comprise placing onto a carrier tape attached to a frame, applying the pressure can comprise applying in a compression chamber, and applying the pressure can comprise a pressure from about 500 KPa to about 5000 KPa.", "In a further embodiment, the method can further comprise heating the wafer while applying the pressure.", "In a still further embodiment, the wafer can be heated to a temperature from about 35 degrees Celsius to about 65 degrees Celsius.", "In another embodiment, the method can further comprise placing a protective film proximate to the first major surface of the wafer before applying the pressure.", "From all of the foregoing, one skilled in the art can determine that, according to another embodiment, a method for batch singulating a semiconductor wafer comprises providing the semiconductor wafer (for example, element 10) having a plurality of die (for example, elements 12, 14, 16, 18) formed on the semiconductor wafer and separated from each other by spaces, wherein the semiconductor wafer has first and second opposing major surfaces (for example, elements 21, 22), and wherein a layer of material (for example, element 28) is formed along the second major surface.", "The method comprises placing the wafer onto a carrier substrate (for example, element 30), wherein the layer of material is adjacent the carrier substrate.", "The method comprises etching the semiconductor wafer through the spaces to form singulation lines (for example, elements 13, 15, 17, 19) and to expose portions of the layer of material in the singulation lines.", "The method comprises applying a pressure substantially uniformly along the second major surface of the semiconductor wafer through the carrier substrate to separate the layer of material in the singulation lines.", "In one embodiment of the foregoing method, applying the pressure can include extruding portions of the carrier substrate into the singulation lines to separate the layer of material, and wherein the portions (for example, element 280) of the separated layer of material remain on the carrier substrate.", "In another embodiment, applying the pressure can include using a fluid filled vessel having a width greater than that of the semiconductor wafer.", "In a further embodiment, applying the pressure can include using a static pressure balloon.", "In a still further embodiment, the static pressure balloon can filled with a heated fluid comprising one or more of a liquid and a gas.", "In another embodiment, providing the semiconductor wafer can include providing the layer of material comprising a conductive material greater than about three microns in thickness, and wherein applying the pressure can comprise a pressure from about 500 KPa to about 5000 KPa.", "From all of the foregoing, one skilled in the art can determine that, according to an additional embodiment, a method of singulating a wafer comprises providing a wafer (for example, element 10) having a plurality of die (for example, elements 12, 14, 16, 18) formed on the wafer and separated from each other by spaces, wherein the wafer has first and second opposing major surfaces (for example, element s21, 22), and wherein a layer of material (for example, element 38) is formed along the second major surface.", "The method comprises placing the wafer onto a carrier substrate (for example, element 30) having an adhesive portion, wherein the layer of material is adjacent the carrier substrate.", "The method separating the wafer through the spaces to form singulation lines (for example, elements 13, 15, 17, 19), wherein singulating lines terminate in proximity to the layer of material.", "The method comprises applying a pressure across the second surface of the wafer to extrude the adhesive portion into the singulation lines to separate the layer of material in the singulation lines, wherein portions (for example, element 280) of the separated layer of material remain on the carrier substrate.", "In one embodiment of the foregoing method the applying step is repeated more than once.", "In another embodiment, applying the pressure can comprise compressing a static pressure balloon (for example, element 73) having a diameter greater than that of the wafer.", "In a further embodiment, applying the pressure can comprise using a fluid filled vessel (for example, elements 73, 74).", "In a still further embodiment, the method can further comprise heating the wafer while applying the pressure.", "In another embodiment, can further comprise placing a pressure plate (for example, element 77) between the fluid filled vessel and the carrier substrate before applying the pressure.", "In a further embodiment, providing the wafer can comprise providing the layer of material having a thickness greater than about three microns and applying the pressure can comprise a pressure between about 500 KPa to about 5000 KPa.", "From all of the foregoing, one skilled in the art can determine that, according to further embodiment, a method for separating a layer of material on a wafer comprises providing the wafer (for example, element 10) having a plurality of die (for example, element 12, 14, 16, 18) formed on the wafer and separated from each other by singulation lines (for example, elements 13, 15, 17, 19), wherein the wafer has first and second opposing major surfaces (for example, elements 21, 22), and wherein a layer of material (for example, element 28) is formed along the second major surface, and wherein the singulation lines extend from the first major surface and terminate proximate to the layer of material, and wherein the wafer is attached to a carrier substrate (for example, element 30).", "The method comprises simultaneously applying a pressure along the entire second major surface of the wafer through the carrier substrate to separate the layer of material in the singulation lines.", "In view of all of the above, it is evident that a novel method is disclosed.", "Included, among other features, is placing a substrate having a layer of material on a major surface of the substrate onto a carrier tape, and forming singulation lines through the substrate to expose portions of the layer of material within the singulation lines.", "A pressure is substantially uniformly applied along the second major surface of the substrate through the carrier tape to separate the layer of material in the singulation lines in a batch configuration.", "In one embodiment, the pressure is applied with a fluid filled vessel that is controllably compressed against the wafer.", "The method provides, among other things, an efficient, reliable, and cost effective process for batch singulating substrates that include back layers, such as thicker back metal layers or WBC layers.", "While the subject matter of the invention is described with specific preferred embodiments and example embodiments, the foregoing drawings and descriptions thereof depict only typical embodiments of the subject matter, and are not therefore to be considered limiting of its scope.", "It is evident that many alternatives and variations will be apparent to those skilled in the art.", "For example, other forms of removable support materials can be used instead of carrier tapes.", "As the claims hereinafter reflect, inventive aspects may lie in less than all features of a single foregoing disclosed embodiment.", "Thus, the hereinafter expressed claims are hereby expressly incorporated into this Detailed Description of the Drawings, with each claim standing on its own as a separate embodiment of the invention.", "Furthermore, while some embodiments described herein include some but not other features included in other embodiments, combinations of features of different embodiments are meant to be within the scope of the invention and meant to form different embodiments as would be understood by those skilled in the art." ] ]
Patent_15874307
[ [ "IMAGE PROCESSING FOR HEAD MOUNTED DISPLAY DEVICES", "Various devices, arrangements and methods for managing communications using a head mounted display device are described.", "In one aspect, tracking data is generated at least in part by one or more sensors in a head mounted display (HMD) device.", "The tracking data indicates one or more facial movements of a user wearing the HMD device.", "A patch image is obtained based on the tracking data.", "The patch image is merged with a facial image.", "Various embodiments relate to the HMD device and other methods for generating and using the patch and facial images." ], [ "1.A method for processing images involving a head mounted display device, the method comprising: obtaining a first set of tracking data, the first set of tracking data generated at least in part by one or more sensors in a first head mounted display (HMD) device and indicating one or more facial movements of a first user, when the HMD device is worn by the first user; obtaining a patch image based on the first set of tracking data that indicates a portion of the face of the first user covered by the first HMD device; obtaining a facial image generated at least in part by capturing a second portion of the face of the first user that is not covered by the first HMD device; and merging the facial image with the patch image such that the merged image indicates the face of the first user including features on the first portion of the face covered by the first HMD device.", "2.The method of claim 1 further comprising: transmitting the merged image to a device.", "3.The method of claim 1 wherein: the patch image is a rendered three dimensional (3D) image; the facial image is a video image generated by a video camera; and the merging involves merging the rendered 3D image with the video image.", "4.The method of claim 1 further comprising: obtaining a 3D model of at least a portion of the face of the first user; adjusting the 3D model based on the first set of tracking data; rendering the adjusted 3D model; and using at least a portion of the rendered 3D model to help form the patch image.", "5.The method of claim 1 further comprising: obtaining a second set of tracking data from a camera device, the second set of tracking data involving one or more of light sensor data and pose data indicating a pose of the head of the first user; and determining the patch image based at least in part on the second set of tracking data.", "6.The method of claim 1 further comprising: obtaining camera device data from a camera device indicating a position of one or more feature points on the head of the first user; obtaining a model of at least a portion of the head of the first user; associating one or more feature points in the model with the one or more feature points in the camera device data; determining a difference between position of the one or more feature points in the model and the position of the one or more feature points in the camera device data; based on the difference, adjusting the position of the one or more feature points in the model; and determining the patch image based at least in part on the model.", "7.The method of claim 1 wherein: obtaining light sensing device data from a light sensing device indicating at least one of 1) a light level around the first user; and 2) a light level on a part of the first user; obtaining a model of at least a portion of the head of the first user; determining a light level simulated on the model; determining a difference between the light level simulated on the model with the light level indicated in the light sensing device data; based on the difference, adjusting the light level simulated on the model; and determining the patch image based at least in part on the model.", "8.The method of claim 1 further comprising: identifying portions of the patch image that intersect with the facial image wherein the patch image indicates the first portion of the face of the first user and the facial image indicates a different, second portion of the face of the first user; and blurring the identified portions of the patch image that intersect with the facial image.", "9.The method of claim 1 further comprising: obtaining a background image indicating a background behind the first user wearing the first HMD device; obtaining a background patch image; and merging the background patch image and the background image wherein the background patch image is positioned in the background image such that the background patch image indicates a part of the background covered by the first HMD device.", "10.The method of claim 1 wherein the method is performed by an image processing device that is connected with the first HMD device through a network and wherein the image processing device is at least one of a server, a camera device that is recording the first user, a television and the first HMD device.", "11.The method of claim 1 further comprising: obtaining one or more images of a second user wherein the one or more images indicate, in real time, facial movements of a portion of the face of the second user that are underneath the second HMD device worn by the second user and wherein the one or more images further indicate, in real time, movements of the head of the second user including portions of the head that are not covered by the second HMD device; and transmitting the one or more images to the first HMD device so that the one or more images can be displayed to the first user.", "12.A computer readable storage medium including executable computer code embodied in a tangible form wherein the computer readable medium comprises: executable computer code operable to obtain a first set of tracking data, the first set of tracking data generated at least in part by one or more sensors in a first head mounted display (HMD) device and indicating one or more facial movements of a first user wearing the first HMD device; executable computer code operable to obtain a patch image based on the first set of tracking data that indicates a portion of the face of the first user covered by the first HMD device; executable computer code operable to obtain a facial image generated at least in part by capturing a second portion of the face of the first user that is not covered by the first HMD device; and executable computer code operable to merge the facial image with the patch image such that the merged image indicates the face of the first user including features on the first portion of the face covered by the first HMD device.", "13.The method of claim 12 wherein: the patch image is a rendered three dimensional (3D) image; the facial image is a video image generated by a video camera; and the merging operation involves merging the rendered 3D image with the video image.", "14.The computer readable medium of claim 12 further comprising: executable computer code operable to obtain a 3D model of at least a portion of the face of the first user; executable computer code operable to adjust the 3D model based on the first set of tracking data; executable computer code operable to render the adjusted 3D model; and executable computer code operable to use at least a portion of the rendered 3D model to help form the patch image.", "15.The computer readable medium of claim 12 further comprising: executable computer code operable to obtain a second set of tracking data from a camera device, the second set of tracking data involving one or more of light sensor data and data indicating a pose of the head of the first user; and executable computer code operable to determine the patch image based at least in part on the second set of tracking data.", "16.A method for revealing face of a user wearing a head-mounted display (HMD) device, the method comprising: obtaining a first image including the user wearing the HMD; obtaining facial features of a portion of the face of the user, wherein the portion of the face is covered by the HMD device; obtaining a second image indicating an environment surrounding the user; generating a patch image based upon a 3-D model of at least the portion of the face, wherein the 3-D model has been adjusted based on the obtained facial features; and rendering a composite image by merging the patch image with the first image and the second image, thus revealing the face of the user.", "17.The method of claim 16, further comprising obtaining the 3-D model of at least the portion of the face, wherein the 3-D model is generated based on scanning of the face of the user.", "18.The method of claim 16, wherein the facial features are tracked by sensors positioned on the HMD device.", "19.The method of claim 18, wherein the tracked facial features indicate one or more facial movements of the user.", "20.The method of claim 16 further comprising: adjusting the 3-D model based on a first set of tracking data; and rendering the adjusted 3-D model." ], [ "<SOH> BACKGROUND <EOH>In the last several years, virtual reality applications have received increasing attention.", "Virtual reality applications involve technologies that immerse the user in a different environment.", "In some applications, the user wears a head mounted display (HMD) device.", "Examples of such devices include the Samsung Gear VR® and the Oculus Rift®.", "Typically, when users wear such devices, their eyes are completely covered.", "The HMD device includes an interior screen that displays images and animation for the user.", "The images give the user the impression that they have been transported into a virtual environment.", "A variety of applications have been contemplated for such HMD devices.", "For example, HMD devices can be used for entertainment applications, such as games in which the user can explore a virtual, fantastical world, and “teleimmersion” applications where the user is transported to another real world location.", "There are ongoing efforts to develop additional applications for HMD devices." ], [ "<SOH> SUMMARY <EOH>In one aspect of the present invention, a head mounted display (HMD) device will be described.", "When worn by a user, the HMD device covers a portion of the face of the user such that the eyes of the user and (large) portions of the face are hidden from view.", "One or more sensors are positioned on the device body.", "The sensor(s) are arranged to track eye movement, eyelid movement, eyebrow movement and/or other facial features of the user.", "A display positioned on the device body is arranged to display an image or media for the user when the HMD device is worn by the user.", "In another aspect of the invention, a method for processing media for use in a communications application will be described.", "Tracking data is obtained.", "The tracking data is generated at least in part by one or more sensors in a HMD device.", "The tracking data indicates one or more facial movements of a user (e.g., gaze, eye rotation, eyebrow or eyelid movements, etc.)", "wearing the HMD device.", "A patch image is obtained based on the tracking data.", "The patch image indicates a portion of the face of the user that is covered by the HMD device.", "A facial image is also obtained.", "The facial image is generated at least in part by capturing a portion of the face of the user that is not covered by the HMD device (e.g., using a camera or any suitable recording/scanning device.)", "The facial image is merged with the patch image such that the merged image indicates the face of the user, which indicates features (e.g., eyes, eyebrows, etc.)", "on the portion of the face of the user covered by the HMD device.", "In various embodiments, the merged image is transmitted to another HMD device so that the facial movements of the user can be displayed in real time at that HMD device.", "Various implementations involve devices, systems and computer code arranged to perform at least some of the above operations." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a divisional of U.S. patent application Ser.", "No.", "14/801,574 (Attorney Docket No.", "SISAP421), filed Jul.", "16, 2015, entitled “IMAGE PROCESSING FOR HEAD MOUNTED DISPLAY DEVICES,” which claims the priority of U.S. provisional patent application No.", "62/163,321, entitled “System for Synthetically Removing Head Mounted Displays from Real-time Video Imagery,” filed May 18, 2015, which are all incorporated herein in entirety for all purposes.", "FIELD OF THE INVENTION The present invention relates generally to the processing of images.", "Various implementations of the present invention relate to the generation and processing of images using a head mounted display device.", "BACKGROUND In the last several years, virtual reality applications have received increasing attention.", "Virtual reality applications involve technologies that immerse the user in a different environment.", "In some applications, the user wears a head mounted display (HMD) device.", "Examples of such devices include the Samsung Gear VR® and the Oculus Rift®.", "Typically, when users wear such devices, their eyes are completely covered.", "The HMD device includes an interior screen that displays images and animation for the user.", "The images give the user the impression that they have been transported into a virtual environment.", "A variety of applications have been contemplated for such HMD devices.", "For example, HMD devices can be used for entertainment applications, such as games in which the user can explore a virtual, fantastical world, and “teleimmersion” applications where the user is transported to another real world location.", "There are ongoing efforts to develop additional applications for HMD devices.", "SUMMARY In one aspect of the present invention, a head mounted display (HMD) device will be described.", "When worn by a user, the HMD device covers a portion of the face of the user such that the eyes of the user and (large) portions of the face are hidden from view.", "One or more sensors are positioned on the device body.", "The sensor(s) are arranged to track eye movement, eyelid movement, eyebrow movement and/or other facial features of the user.", "A display positioned on the device body is arranged to display an image or media for the user when the HMD device is worn by the user.", "In another aspect of the invention, a method for processing media for use in a communications application will be described.", "Tracking data is obtained.", "The tracking data is generated at least in part by one or more sensors in a HMD device.", "The tracking data indicates one or more facial movements of a user (e.g., gaze, eye rotation, eyebrow or eyelid movements, etc.)", "wearing the HMD device.", "A patch image is obtained based on the tracking data.", "The patch image indicates a portion of the face of the user that is covered by the HMD device.", "A facial image is also obtained.", "The facial image is generated at least in part by capturing a portion of the face of the user that is not covered by the HMD device (e.g., using a camera or any suitable recording/scanning device.)", "The facial image is merged with the patch image such that the merged image indicates the face of the user, which indicates features (e.g., eyes, eyebrows, etc.)", "on the portion of the face of the user covered by the HMD device.", "In various embodiments, the merged image is transmitted to another HMD device so that the facial movements of the user can be displayed in real time at that HMD device.", "Various implementations involve devices, systems and computer code arranged to perform at least some of the above operations.", "BRIEF DESCRIPTION OF THE DRAWINGS The invention and the advantages thereof, may best be understood by reference to the following description taken in conjunction with the accompanying drawings in which: FIG.", "1 is a diagram of a communication system involve multiple head mounted display (HMD) devices according to a particular embodiment of the present invention.", "FIG.", "2A is diagram of a user who is wearing an HMD device according to a particular embodiment of the present invention.", "FIG.", "2B is a diagram of a user without an HMD device according to a particular embodiment of the present invention.", "FIGS.", "3A and 3B are flow charts illustrating an example method for managing the communication system illustrated in FIG.", "1.FIG.", "4 is a diagram illustrating an example three dimensional model of the face of a user according to a particular embodiment of the present invention.", "FIG.", "5A is a diagram illustrating an example image of a user in a room according to a particular embodiment of the present invention.", "FIG.", "5B is a diagram illustrating an example background image according to a particular embodiment of the present invention.", "FIG.", "6 is a diagram illustrating a camera device and a user wearing a HMD device according to a particular embodiment of the present invention.", "FIG.", "7A is a diagram illustrating an image of a face of a user according to a particular embodiment of the present invention.", "FIG.", "7B is a diagram illustrating a three dimensional model of the face of the user illustrated in FIG.", "7A.", "FIG.", "8 is a diagram illustrating a technique for sensing light levels according to a particular embodiment of the present invention.", "FIG.", "9A is a diagram illustrating a live image of a user wearing an HMD device according to a particular embodiment of the present invention.", "FIG.", "9B is a diagram illustrating a rendered model of the face of the user illustrated in FIG.", "9A.", "FIG.", "10 is a diagram illustrating a technique for identifying a region for a patch image in a model according to a particular embodiment of the present invention.", "FIG.", "11 is a diagram illustrating a patch image according to a particular embodiment of the present invention.", "FIG.", "12 is a diagram illustrating a region for a patch image in a facial/background image according to a particular embodiment of the present invention.", "FIG.", "13 is a diagram illustrating a merging of a patch image and a facial/background image according to a particular embodiment of the present invention.", "FIG.", "14 is a diagram illustrating a technique for identifying regions in a background image according to a particular embodiment of the present invention.", "FIG.", "15 is a diagram illustrating a technique for merging a background patch image into a facial/background image according to a particular embodiment of the present invention.", "FIGS.", "16, 17 and 18 are diagrams illustrating perspective, back and front views of an HMD device according to a particular embodiment of the present invention.", "FIG.", "19 is a block diagram of a HMD device according to a particular embodiment of the present invention.", "FIG.", "20 is a block diagram of an image processing device according to a particular embodiment of the present invention.", "In the drawings, like reference numerals are sometimes used to designate like structural elements.", "It should also be appreciated that the depictions in the figures are diagrammatic and not to scale.", "DETAILED DESCRIPTION The present invention relates to methods, devices, systems and arrangements for the processing and generation of images for head mounted display (HMD) devices.", "Various implementations allow one user of an HMD device to view the facial expressions of another user, even when all of the users are wearing HMD devices that cover a large portion of their faces.", "As described in the Background, games are a popular application for many virtual reality and HMD device applications.", "One other possible application is communications e.g., virtual reality or video conferencing between users of HMD devices.", "An example of a system 100 for users of HMD devices is illustrated in FIG.", "1.The communication system 100 includes two users, user 105a and user 105b.", "Each user is wearing a HMD device 110a/110b and is situated in a room (rooms 130a and 130b).", "In each room there is also a camera device (camera devices 115a and 115b) that is positioned a short distance away from its respective user.", "The HMD devices and/or camera devices are coupled with one another using a network 125.In some embodiments, there is a server 120 that helps process media and manage communications between the HMD devices.", "In this example, the camera device 115a directs a camera at the face of the user 105a in room 130a.", "The camera device 115a is arranged to record the facial expression and movements of the user 105a, as well as possibly the background of the room 130a behind the user 105a.", "In some implementations, the camera device 115a captures a live video stream of the user 105a.", "The camera device 115a transmits the recorded video data through a network 125 (e.g., the Internet) in real time so that the other user 105b can view the video stream using the HMD device 110b.", "In some embodiments, the camera device 115b receives the recorded data and transmits it to the HMD device 110b for user 115b.", "Alternatively, in other embodiments the HMD device 110b is directly connected to the network 125 and is arranged to receive the recorded data directly from the network 125.Based on the recorded video data, the HMD device 110b worn by user 105b then renders the video stream.", "Accordingly, the HMD device 110b displays the face and movements of the other user 105a in real time.", "In this example, the communication between the user 105a and 105b is two-way.", "That is, the camera device 115b for the user 105b records the face and movements of the user 105b and transmits associated video data to the user 105a across the network 125.Each HMD device also includes microphones that capture the speech of each user.", "This speech is converted into audio data that is also transmitted in real time to the other user across the network 125.Thus, the users 105a/105b are able to communicate with one another in real time, while also viewing each other's faces using their HMD devices.", "Although the above communication system is useful, there is a problem related to the use of the HMD devices.", "This problem is illustrated in FIGS.", "2A and 2B.", "FIG.", "2A is a diagram illustrating the face of user 105a when the user 105a is wearing the HMD device 110a.", "That is, the diagram represents a view of the user 105a as seen from the perspective of the camera device 115a.", "Thus, the diagram also represents the view of the user 105a as seen by the other user 105b.", "As shown in the diagram, the HMD device 110a entirely covers the eyes and other regions on the face of the user 105a such that they are not visible to the camera device 110a or the user 105b.", "For human communication and interaction, however, the ability to view a person's eyes and facial movements is valuable.", "Gaze, eyebrow movement and other facial movements are important elements in a conversation.", "They can help convey the emotion or intent of the speaker.", "The ability to view facial movements would help the communication illustrated in FIG.", "1 to be significantly more engaging and lively.", "In many situations, a user of an HMD device who is participating in a video conference would prefer to see the entire face of the other conference participant, as represented by the face 210 illustrated in FIG.", "2B.", "That is, it is generally preferred that the HMD device 110a be removed and that the eyes and facial expressions of the user be visible.", "Various implementations of the present invention address this issue.", "In some approaches, a patch image is generated.", "That is, in various embodiments, the image of the user 105a wearing the HMD device 110a (e.g., as shown in FIG.", "2A) is “patched” such that the HMD device 110a is removed.", "The patch image fills in the space covered by the HMD device and simulates the facial features and movements of the user (e.g., eyes, gaze, eyelid or eyebrow movements, etc.)", "that would otherwise be hidden by the HMD device 110a.", "In various embodiments, the patch image is based on a rendered 3D model of corresponding portions of the user's face and/or reflects in real time the facial movements and expressions of the user 105a.", "This allows a viewer to see a simulation of the entire face of the user e.g., similar to the face 210 illustrated in FIG.", "2B.", "Referring next to FIGS.", "3A and 3B, an exemplary method 300 for processing imagery for HMD device communication applications will be described.", "In this example, the method is performed primarily using the HMD device 110a, camera device 115a, user 105a and room 130a illustrated in FIG.", "1.Although the method 300 describes various operations being performed by particular devices, it should be appreciated that any operation may instead be performed by any suitable device.", "By way of example, the method describes a camera device 115a that performs various image collection, generation and processing steps, but the same steps may also be performed by the HMD device 105a, the server 120, or another computing device (e.g., a smartphone, a television, a game console, a computer, etc.)", "Initially, at step 305, a three dimensional (3D) model 405 of the face of the user 105a is obtained.", "Generally, the model 405 may be any software model, graphical model and/or mathematical/virtual representation of any part of the user 105a (e.g., the face, head, eyes, eyebrows, any part of the body, etc.)", "A simplified example is illustrated in FIG.", "4.In this example, the 3D model indicates, shows and/or represents the head, face and various facial features of the user 105a (e.g., surface and shape of the head and face, eyes, nose, mouth, skin texture, color, light level, shading, etc.).", "In various implementations, the model is fully three dimensional (i.e., the model can be rotated or tilted in three dimensions) and/or may be modeled using multiple polygons, a mesh, vertices, edges, etc.", "The software for the 3D model 405 may also be capable of automatically adjusting features in the model 405 based on input.", "By way of example, when input is received indicating that the lips should smile, other features in the 3D model 405 may also automatically move in response (e.g., there may be slight movements in the nose or in the area around the lips, etc.", "), thus simulating the many tiny movements that naturally occur in a human face when one part of the face changes or when a particular expression is desired.", "The 3D model 405 may simulate the entire face, head or body, or any portion of the head or body of the user 105a.", "The 3D model 405 may be generated in any suitable manner using any known software or hardware.", "In various embodiments, the 3D model 405 is generated using a camera or any other suitable scanning device (e.g., camera device 115a, a 3D scanner, etc.)", "Generally, the scanning device is used to capture the face of the user when the user is not wearing the HMD device 110a (e.g., before step 313, when the user wears the HMD device 110a and steps in front of the camera device 115a to communicate with another user.)", "In other embodiments, the 3D model 405 is predefined.", "That is, the model 405 may be generic and/or may not be specifically tailored to or based on the actual face of the user 105a.", "Such a model is suitable for applications in which the user does not wish another user to see their real face, but perhaps only a face of a virtual reality avatar or character.", "In the illustrated embodiment, the camera device 115a either generates the model 405 itself, or obtains the model 405 from an external source.", "For example, if another scanning device generated the model, the camera device may download the model data from the scanning device over a network (e.g., the network 125.)", "Alternatively, the model data may be transferred to the camera device 115a using any other suitable technique e.g., using a flash drive, etc.", "In this example method 300, the camera device 115a will later adjust and process the model 405, as will be described later in this application.", "Returning to FIG.", "3A, at step 310, the camera device 115a obtains a background image.", "A background image is any image of a background or environment, as seen from the perspective of a scanning or camera device (e.g., camera device 115a.)", "Generally, the background image captures a portion of the surrounding environment that will later be blocked from view when the user wears the HMD device 110a and steps in front of the camera device 115a to communicate with another user (e.g., as described in step 313.)", "An example of a background image is illustrated in FIGS.", "5A and 5B.", "FIG.", "5A is an image 505 of the user 105a from the perspective of the camera device 115a.", "In this image 505, the user 105a is positioned in front of the camera device 110a and is using the HMD device 110a to communicate with another user 105b (e.g., as described in step 313 below.)", "The image 505 thus portrays the face 410 of the user, the HMD device 110a, parts of the user's body as well as portions of the background.", "In this example, the camera device 115a was used to capture the image 505.FIG.", "5B is a background image 510 that is generally the same as the image illustrated in FIG.", "5A (i.e., taken from the same perspective and by camera device 115a), except that the user 105a is absent from the image.", "In various embodiments, the background image 510 is taken before the image 505 was taken.", "The background image 510 captures at least a portion of the background that would otherwise be blocked from view by the user 105a in image 505.Such portions in the background image 510 can be used for various image processing steps (e.g., steps 370-375), as will be discussed later in this application.", "The background image 510 may be generated in any suitable manner In some embodiments, for example, the camera device 115a scans or captures one or more images of the background before the user enters into its field of view and blocks parts of the background.", "In still other embodiments, a camera/scanning device other than the camera device 115a captures the background.", "By way of example, if a particular camera/scanning device is properly positioned behind the user 105a when the user 105a is using the HMD device 110a and camera device 115a to participate in a video conference (e.g., step 313), the camera/scanning device can capture the background behind the user at any time.", "The camera can then transfer the resulting background image 510 to the camera device 115a for additional processing.", "The background image 510 may be stored in any suitable media/image format e.g., image files, video files, etc.", "Returning to FIG.", "3A, at step 313 the camera device 115a captures an image of the user 105a, who is now wearing the HMD device 110a and is using the device to communicate with another HMD device user 105b.", "The user 105a is situated in front of the camera device 115a, as illustrated in FIG.", "6.In this particular embodiment, the camera device 115a is a video camera and is generating a live video feed of the user 105a and his or her surrounding background.", "The video feed is made of multiple individual images (e.g., video frames.)", "An example of such an image is image 505 of FIG.", "5A, which was discussed above.", "Such images are hereinafter referred to as live images i.e., they are a photographic or photo-like visual recording of the user 105a and background, rather than a rendered, graphical model of the same.", "However, it should be appreciated that the camera device 115a may use any suitable type of video, camera, scanning, rendering and/or monitoring technology, and is not limited to generating the types of images and video described above.", "To wear the HMD device 110a, the user 105a secures the HMD device 110a to his or her head.", "In this particular example, the HMD device 110a entirely covers the eyes of the user 105 and/or prevents any outside light, objects or images from being perceived by the user (although this is not a requirement and the HMD device may have a variety of different features and form factors.)", "The HMD device 110a includes a display unit that displays video, images and/or graphics to the wearer of the device 110a.", "As will be discussed below in greater detail, the HMD device 110a also includes one or more internal sensors and components that are used to gather information on the portions of the user's face that are covered by the HMD device 110a.", "Afterward, at step 315, the HMD device 110a tracks particular facial features of the user 105a.", "Any facial feature that is covered by the HMD device 110a may be tracked.", "In some embodiments, for example, the tracked facial features or movements include but are not limited to gaze (e.g., eye rotation), eyelid movement and eyebrow movement.", "Any suitable software, hardware or sensors may be used inside the HMD device 110a to help track such features.", "In the illustrated embodiment, the HMD device 110a is arranged to track gaze or eye rotation, as well as one or more facial movements (e.g., the movements of the upper and/or lower eyelids.)", "Such tracking may be performed using any known technology or technique (e.g., optical tracking, electrooculography etc.)", "In some approaches, the HMD device 110a includes one or more light sources and sensors (e.g., tracking cameras.)", "These devices are generally positioned on the interior of the HMD device 110a i.e., once the HMD device 110a is worn by the user, the sensors/cameras are hidden from view, have access to and are in close proximity to the portion of the face that is covered by the HMD device 110a.", "In this example, there are one or more tracking cameras that capture images of one or more facial features (e.g., eyelid, gaze, eye rotation, etc.).", "The images are later processed to determine the movement of the facial feature over time.", "In various embodiments, the HMD device also includes one or more light sources.", "These light sources are positioned on the interior of the HMD device and are arranged to project light at the eyes, eye region or other portions of the face covered by the HMD device.", "Each light source emits light that facilitates the tracking of the facial features (e.g., infrared light.)", "The light source(s) and camera(s) may be positioned in any suitable configuration on the HMD device 110a.", "(An example arrangement of IR light sources 1610 and tracking cameras 1615 in the HMD device 110a are illustrated in FIG.", "17, which will be described in greater detail later in the application.)", "The HMD device 110a may also use devices and sensors other than cameras to track facial movements and features.", "In some embodiments, for example, the HMD device 110a detects motion on portions of the face using a biometric sensor unit: e.g.", "electromyography (EMG), electrooculography (EOG).", "In the embodiment illustrated in FIG.", "17, for example, an EMG sensor unit takes the form of a line of sensors 1605 that rests flush against the forehead, eyebrows and cheeks of the user when the user wears the HMD device 110a.", "Another example is that an EOG sensor unit takes the form of sensors 1605b that detects eye rotation and eyelid movement.", "In other implementations, the sensors may be arranged in any suitable configuration on the HMD device.", "The EMG sensor unit detects electrical impulses generated by muscle motion in the face of the user.", "These electrical impulses are stored and analyzed to determine the motion of a portion of the user's face (e.g., the movement of the eyebrows) over time.", "The EOG sensor unit measures electric potentials to detect eye movement via electrode probes.", "Returning to FIG.", "3A, at step 320, the camera device 115a obtains data relating to the above tracking (e.g., data generated using a camera tracking the gaze of the user, EMG/EOG sensor data, any data used to track any facial movements or feature covered by the HMD device, etc.).", "In the illustrated embodiment, the camera device 115a is coupled with the HMD device using a wired or wireless network.", "The HMD device 110a transmits the HMD device tracking data to the camera device 115a through the network.", "The camera device 115a processes the data received from the HMD device 110a to determine what sort of facial movements or expressions are indicated by the data.", "In various embodiments, for example, the camera device 110a processes the images of various facial features (e.g., eye rotation, eyelids, etc.)", "that were captured over a period of time.", "The camera device then analyzes the images in order to determine how the facial features moved during that time period.", "Additionally, the camera device 115a analyzes EMG/EOG data received from the HMD device 110a to determine what types of movements (e.g., eyebrow movements) are indicated by the data.", "The camera device 115a then adjusts the 3D model 405 based on the HMD device tracking data (step 325).", "That is, one or more selected facial movements/positions (e.g., changes in gaze, eye rotation, eyebrow movement/position, eyelid movement/position, etc.)", "detected in step 315 are used to adjust the 3D model 405.Generally, the 3D model 405 is adjusted to at least somewhat incorporate the facial changes, features or movements detected by the HMD device 110a.", "Thus, for example, if a movement in the eyebrow or eyelid of the user 105a was detected, the 3D model 405 is adjusted to simulate that movement.", "If a shift in the gaze of the user was detected, then the 3D model 405 is adjusted accordingly so that it substantially mirrors or copies the shift.", "At step 330, the camera device 115a tracks various features related to the face of the user 105a or the surrounding environment.", "In some embodiments, for example, the camera device 115a measures or tracks the amount of ambient light (e.g, in the room 130a) using a light sensor.", "Additionally or alternatively, the camera device 115a detects the amount of light on a portion of the body or face of the user 105a.", "Any changes in this light level are recorded by the camera device 115a over time.", "Some implementations of the camera device 115a also track changes in the pose or orientation of the face/head of the user.", "The camera device 115a may also track any other facial feature or movement of the user (e.g., any facial movements or features in the portions of the face that are not covered by the HMD device 110a, such as the mouth, lips, cheeks, chin, etc.)", "In some approaches, the camera device tracks a feature, light or marker on the HMD device (e.g., light emitting device 1605 in FIG.", "16) to help determine changes in the pose of the face/head of the user 105a.", "It should be appreciated that there may be multiple camera and/or light sensing devices that gather the above tracking/lighting data.", "The camera/light sensing devices may be distributed in various places in the room 130a and monitor the user 105a and the ambient environment from different angles.", "In that case, these other camera/light sensing devices are coupled to the camera device 115a through a network and the camera device obtains the tracking/lighting data from the other camera/light sensing devices through the network (step 335), so that the camera device 115a can further process the data.", "In some designs, a light sensing device/sensor is on the HMD device 110a.", "In various applications, the HMD device 110a obtains the light sensor data and transmits it to the camera device 115a for further processing and analysis.", "Of course, if the camera device 115a is the only device that generates tracking/light sensing data, the camera device 115a can obtain the data without requiring any transfer of the data through a network.", "In still other embodiments, the camera device 115a is replaced by an image processing device (e.g., the image processing device 2000 of FIG.", "20, the server 120 of FIG.", "1, etc.", "), which does not itself capture images using a camera and/or sense ambient light levels, but instead obtains tracking/lighting/sensor data from one or more camera/light sensing devices/sensors positioned in the room 130a and processes the obtained data (e.g., as described in steps 320, 325, 335-380 of FIGS.", "3A and 3B.)", "Once the camera device 115a obtains the above tracking/lighting data, the 3D model 405 is adjusted based on the data (step 340).", "In various implementations, the camera device 115a analyzes the collected tracking/lighting data e.g., multiple images of the face of the user.", "The camera device 115a performs image processing to determine what kinds of facial movements are indicated in the images.", "Based on the analysis and image processing, the camera device adjusts the model 405.Generally, the model 405 is adjusted to simulate one or more changes that were sensed, detected or tracked in step 330.By way of example, if the light level changed, a tone on the surface of the model 405 may be changed to reflect the difference in the light level.", "If the position or orientation of the head or the user 105a shifted, then that shift would be reflected in the model 405 as well.", "If the shape or position of particular facial features changed (e.g., a movement of the lips, cheeks, etc.", "), then the model 406 id adjusted based on the detected change.", "The aforementioned tracking may be performed in a variety of ways, depending on the needs of a particular application.", "In various implementations, for example, the camera device 115a is arranged to track changes in the pose or orientation of the head or face using one or more feature points.", "Any known technology or technique may be used to perform such tracking.", "An example of one approach is shown in FIGS.", "7A and 7B.", "FIG.", "7A is a diagram representing an image 410 of the actual face of the user 105a (e.g., as shown in image 505 of FIG.", "5A.)", "The camera device 115a captured the image while it was pointed at the user, who at the time was wearing the HMD device 110a and was using it to communicate (e.g., as previously described in connection with FIG.", "6 and step 313.)", "The location of the HMD device 110a is shown by the dotted line region.", "In this simplified example, the camera device 115a selects two feature points 705a and 710a.", "The feature points may be on any portion of the face of the user.", "In various implementations, the feature points are chosen such that they are readily identifiable due to their proximity to particular facial features e.g., such as the ends of the mouth, the tip of the nose, etc.", "FIG.", "7B is a diagram representing the 3D model 405 of the face (e.g., the 3D model obtained in step 305 of FIG.", "3A.)", "The camera device 115a identifies one or more feature points 705b and 710b in the model 405 that correspond to the feature points 705a and 710a selected in the facial image 410.The camera device 115a then compares the positions of the feature points 705a/710a in the facial image 410 to those of the feature points 705b/710b in the model 405.In this particular example, there is a difference between the two sets of feature points, since the head depicted in the 3D model 405, unlike the head in the image 410, is oriented more to one side, rather than looking straight ahead.", "In various embodiments, the camera device 115a then computes a difference or error between the position of the feature point(s) 705a/710a identified in the facial image 410 and the position of the feature point(s) 705b/710b identified in the model 405 (FIG.", "7B.)", "Based on the difference/error, the camera device 115a then adjusts the model 405.In the illustrated embodiment, the difference in the relative positions of the feature points reveal that the orientation of the model 405 is slightly incorrect.", "The model 405 is then adjusted or reoriented so that the difference is reduced.", "This adjustment helps cause the model 405 to orient itself properly i.e., so that the orientation of the model 405 better resembles that of the facial image 410.A somewhat similar technique can be applied to lighting.", "FIG.", "8 and FIG.", "7B illustrate one example approach involving light detection/sensing.", "FIG.", "8 illustrates an image 505 of a user 105a, which is captured by the camera device 115a (e.g., as described in step 313.)", "The camera device 115a identifies a region 810a on the face of the user 105a in the image.", "The camera device 110a determines an approximate light level at that region 810a.", "The camera device 115a identifies a corresponding region 810b on the face of the model 405 illustrated in FIG.", "7B.", "That is, the region 810b is in the same general location on the modeled face as the region 810a on the face in the image 505.The camera device 115a estimates the light level or tone simulated at the region on the model 405.The light levels of the regions 810a and 810b are compared and/or a difference or error between them is determined.", "Based on the difference in light levels, the model 405 is adjusted.", "Generally, the model is adjusted so that the difference is reduced and the light level simulated on the face of the model 405 is more similar to the light level on the face in the image 505.Returning to FIGS.", "3A and 3B, once the model has been adjusted as described in steps 325 and 340, the model 405 is rendered (step 345 of FIG.", "3B.)", "That is, in various embodiments, the model 405, which was stored and adjusted in a software application, is rendered to generate a three dimensional graphical model 905 that resembles the actual face of the user 105a.", "A simplified example is illustrated in FIGS.", "9A and 9B.", "FIG.", "9A is a diagram representing a live image 410 of the actual face of the user 105a, as captured by the camera device 115a (e.g., as described in step 313 of FIG.", "3A.)", "The camera device captured the image while the user was wearing an HMD device and using it to communicate with another user (e.g., as described in connection with FIG.", "6.)", "Thus, in FIG.", "9A, much of the face of the user 105a is covered with the HMD device 110a.", "FIG.", "9B represents an image of the corresponding rendered model 905, which due to the real time adjustments made in steps 325 and 340, closely resembles the actual face of the user 105a in the image 410 in terms of pose, orientation and light levels.", "In contrast to the actual face of the user 105a as seen by the camera device 115a in image 410 or 505, the face of the rendered model 905 is not covered with an HMD device 110a.", "Additionally, due in part to adjustments made to the model in step 325, the facial features (e.g., eyes, eyebrows, eyebrow position, eyelids, gaze, eye rotation, etc.)", "of the user 105a which are hidden in image 410 (FIG.", "9A) by the HMD device 110a are simulated in the rendered model 905 of FIG.", "9B.", "In this particular application, it is intended that the live image 410 of the actual face of the user 105a and its background will be transmitted to another user 105b to facilitate real time communication.", "Thus, the other user 105b will be able to see the face of the user 105a while they are communicating.", "As previously discussed, one challenge of that approach, however, is that the HMD device 110a covers a large portion of the face of the user 105a, thus making the real time communication less engaging and personal.", "To address this issue, the camera device 115a obtains a patch image (step 350).", "In various embodiments, a patch image is an image from a model (e.g., rendered model 905) that is combined with or merged with another image (e.g., live image 410 or 805) to form a composite image.", "Put another way, the image 410/505 of the user 105a wearing the HMD device 110a is “patched” such that the HMD device 110a is removed and a rendered image is put in its place.", "The rendered image includes one or more facial features (e.g., eyes, eyelids, eyebrows, part of the nose, etc.)", "that underlie the HMD device.", "In this example, this allows another user 105b who is communicating with the user 105a to see at least representations of the eyes and eyebrows of that user, which makes the conversation more natural and engaging.", "Additionally, those facial features, although simulated, will track and imitate in real time the movements of corresponding features of the actual user 105a.", "One example approach for generating a patch image is illustrated in FIG.", "10.FIG.", "10 illustrates the rendered 3D model 905 of the head of the user.", "The model 905 has been adjusted based on tracking/lighting data obtained by the camera device 115a (e.g., as discussed in steps 315-450 of FIG.", "3A).", "The camera device 115a identifies a region 1005 of the 3D model that corresponds to the HMD device 110a, as seen in the image 410/505 (e.g., FIG.", "5A) of the user 105a, which shows the actual face of the user as seen by the camera device 115a.", "The region 1005 is illustrated in FIG.", "10 as a square region made of dotted lines.", "In this example, the region 1005 is generally the same size, shape and/or in the same position relative to the face of the user 105a as the HMD device 110a in the image 410/505 of the user 105a.", "Accordingly, in this example, the region 1005 has a rectangular shape, which resembles the shape of the HMD device 110a in live image 410 (FIG.", "9A).", "Afterward, the portion of the rendered 3D image 905 that falls into the region 1005 is extracted, copied or generated from the rendered 3D model 905.This step is illustrated in FIG.", "11.In FIG.", "11, only the portion of the rendered model 905 that is within the boundaries of the region 1005 remains.", "Other portions of the rendered 3D model 905 have been removed.", "The extracted portion of the rendered model 905 is a patch image 1105.Returning to FIG.", "3B, at step 355, one or more edges of the patch image 1105 is blurred or softened.", "That is, the camera device 115a analyzes the patch image 1105, the live image 410/805 and/or the rendered model 905 to determine locations or edges on the patch image that will later merge into another object (e.g., the face of the user 105a.)", "The camera device 115a then blurs, dilates and/or softens those edges using any suitable image processing technique.", "In the illustrated embodiment of FIG.", "11, for example, an analysis of the live image 410/805 and/or the patch image 1105 reveals that if the patch image 1105 is merged into the live image 410/805 such that it replaces the HMD device 110a, the top and bottom edges of the patch image 1105 will merge into the face of the user 105a, as seen in the live image 410/805.To make the merging of the patch image 1105 and the face in the image 410/505 more seamless, the top and bottom edges of the patch image 1105 are thus dilated or blurred to soften the edges (as marked by dotted line regions 1110a and 1110b.)", "Any suitable compositing technique may be used to blue or soften the edges of the patch image.", "On the other hand, the same analysis also reveals that the left and right edges of the patch image will not be merging into the face of the user 105a in the live image 410/805 and instead will mix only with the background.", "Thus, in this example those edges are not dilated or blurred.", "Returning to the method of FIG.", "3B, at step 360, the camera device 115a obtains a facial/background image.", "In this example, the facial/background image is the image taken by a camera/scanning device (e.g., camera device 115a) that captures an image of the face of a user wearing the HMD device.", "The facial/background image may also capture a wide variety of other parts of the body of the user and/or a surrounding background.", "An example of a facial/background image 1205 is the image 505 illustrated in FIG.", "5A and 12.As previously described, the image 505 was taken by the camera device 115a in step 313 of FIG.", "3A.", "In this example, the facial/background image 1205 is a live image i.e., a video frame of a video that includes live footage of the user.", "In other embodiments, however, the facial/background image may include a wide variety of elements (e.g., only the face or part of the face of the user, no background, etc.)", "and/or use a different type of media or image (e.g., a photographic image, a rendered image or model, etc.)", "In the illustrated embodiment, the user 105a is standing in a room 130a with a colored wall and various types of furniture in the background.", "The user 105a is wearing the HMD device 110a.", "At step 365, the patch image 1105 and the facial/background image 1205 are merged.", "In some embodiments, the patch image 1105 is superimposed over or replaces a region of the facial/background image 1205 that includes the HMD device 110a.", "Alternatively, a portion of the facial/background image 1205 containing the HMD device 110a is removed and the patch image 1105 is inserted, blended and/or merged into the facial/background image 1205 into the same position that the HMD device 110a previously occupied.", "An example of this merging process is illustrated in FIG.", "13, in which the patch image 1105 has taken the place of the HMD device 110a illustrated in FIG.", "12.The merging of the facial/background image 1205 and the patch image 1105 results in a composite image 1305.Any suitable type of image processing technique, including processes not described above, may be performed to make the new composite image.", "In some but not necessarily all situations, additional adjustment of the composite image 1305 is desirable.", "For example, in the illustrated embodiment, a review of the composite image 1305 in FIG.", "13 reveals a problem.", "The patch image 1205 in many respects follows the contours of the shape of the removed HMD device 110a, and thus tightly fits into the space that the HMD device 110a used to occupy.", "However, there are regions in the facial/background image 1205 that are not yet properly filled in.", "These are non-facial regions 1310 that were previously covered by the HMD device 110a and that make up parts of the background.", "In the example illustrated in FIG.", "13, these regions 1310 are on either side of the head of the user 105a, although depending on how the head and HMD device 110a are oriented, in some cases only one region may be visible.", "To help address this issue, at step 370, a background patch image is obtained.", "To do this, the camera device 115a analyzes the background image 510 obtained in step 310.This background image 510, which is illustrated FIG.", "5, is an image of the background without the presence of the user 105a.", "Generally, the background image 510 covers at least some of the same parts of the background that were shown in the facial/background image 1205, as well as parts of the background that are hidden or covered in image 1205 by the user 105a and/or the HMD device 110a.", "Thus, the background image 510 contains the information that is needed to fill in the non-facial regions 1310 i.e., the color or texture of the background that would lie behind the non-facial regions which were covered by the HMD device 110a in the facial/background image 1205.The camera device 115a determines regions in the background image 510 that correspond to the non-facial regions 1310 (e.g., have the same approximate position, are in the same general location and/or display the same part of the background.)", "An example of this determination is illustrated by regions 1410 in FIG.", "14.Based on the above determination and analysis of the background image 510, the camera device 115a generates a suitable background patch image 1415.The background patch image 1415 includes/simulates the colors, shading, appearance and/or textures of the identified regions 1410 in the background image 505.At step 375, the background patch image(s) and the composite image 1305 are combined or merged.", "An example of this is illustrated in FIG.", "15.The non-facial regions have now been filled in with background patch image(s) 1415.The background patch image(s) 1415 may be images pre-generated using the regions 1410 in the background image 505, which are then merged with the composite image 1305.In some embodiments, the camera device 115a fills in or paints the regions 1310 in composite image 1305 with one or more colors, texture and/or shading such that they resemble regions 1410 in the background image 505.As a result of the above steps of method 300, a live image (e.g., image 505/1205) of a user 105a wearing an HMD device 110a has been adjusted to remove the HMD device.", "In place of the HMD device, simulated eyes and other portions of the face have been provided using a patch image 1105.In various embodiments, the steps of the method 300 in FIGS.", "3A and 3B are repeated for each video frame of a live video feed of the user 105a.", "That is, for each video frame, facial features are tracked (e.g., steps 315 and 330), a model is adjusted (e.g., steps 325 and 340), a patch image is obtained (e.g., step 350), and the patch image is merged into a facial/background image to form a composite image.", "In some designs, each composite image is an adjusted video frame of a live video stream in which the HMD device has been removed and replaced with a suitable patch image.", "Returning to the method 300 of FIG.", "3B, the camera device 115a transmits the composite image data (e.g., video data made of many of the aforementioned composite image video frames) to a recipient HMD device 110b, which is being worn and used by another user 105b of FIG.", "1 (step 380).", "The recipient HMD device 110b receives the composite image data over the network 125 and renders the received composite image data.", "Over time, as the user 105b receives multiple such composite images, the user will be able to view the changing facial expressions of the user 105a in real time.", "In various embodiments, the user 105b will even be able to view expressive, moving, simulated eyes and eye regions, even though at that time the person generating those expressions has his or her eyes covered with an HMD device.", "In various implementations, the steps of the method 300 are performed by two or more HMD devices (e.g., HMD devices 110a and 110b) concurrently.", "That is, camera device 115a obtains a facial/background image 505/1205 of the user 105a (e.g., step 313), the facial features of the user 105a are tracked (e.g., steps 315 and 330), a patch image 1105 is generated (e.g., step 350), the patch image 1105 is merged into the facial/background image 1205 and the resulting composite image 1305 is sent to user 105b for rendering at the HMD device 110b.", "Similarly and concurrently, camera device 115b obtains a facial/background image of the user 105b, the facial features of the user 105b are tracked, a patch image is generated, the patch image is merged into the facial/background image and the resulting composite image is sent to user 105a for rendering at the HMD device 110a and viewing by the user 105a.", "The tracking, generation and transmission of the composite images occur in real time.", "Even though each user is wearing an HMD device, the user can see simulated eyes and other facial features of the other user.", "These simulated facial features follow the actual facial movements of the corresponding user in real time, thus creating a significantly more engaging, interactive and personal communication experience.", "Some of the embodiments described above relate to a system in which two users with two HMD devices are communicating with one another.", "However, it should be appreciated that the system is not limited to such applications.", "By way of example, most or almost all of the operations illustrated in FIGS.", "3A and 3B may be applied to a system in which there is only one user 105a who uses an HMD device 110a and/or a camera device 115a (FIG.", "1).", "Steps 305-375 are performed as described above.", "Steps 380 and 385 may also be performed, except the composite image is not necessarily transmitted to another user 105b or HMD device 110b.", "Instead, the composite image is provided to or transmitted over a network to any suitable receiving device e.g., a television, a smart phone, a tablet, any suitable computing device or display device, etc.", "In various embodiments, the receiving device is arranged to display the composite image.", "In some approaches, the composite image(s) are received in real time, although this is not a requirement and the composite image(s) may be received at any time.", "That is, the composite image(s) may be generated for any suitable purpose or device, and are not limited to being displayed at another HMD device or for communication applications.", "Referring next to FIG.", "16-19, a head mounted display (HMD) device 1600 according to a particular embodiment of the present invention will be described.", "The HMD device 1600 may be any suitable head mounted display device (e.g., the HMD device 110a of FIG.", "1).", "Perspective, back and front views of an example HMD device 1600 are illustrated in FIGS.", "16-18.FIG.", "19 is a diagram illustrating various components of the HMD device 1600.The HMD device 1600 includes a processor unit 1905, which includes one or more processors, a storage unit 1910, a display unit 1920, a network interface unit 1915, a light emitter unit 1925, a sensor unit 1930, an HMD device control module 1935 and a power source 1940.In various implementations, the processor unit 1905 is not used or is not (primarily) responsible for the processing of images or other operations described below.", "Instead, any data/images to be processed is transferred to a remote device and the processing is performed by the remote device (e.g., the server 120, a game console, the camera device 115a, a television, any suitable computing device, etc.)", "The light emitter unit 1925 includes one or more light emitting devices.", "Any suitable type of light emitting device or light emitting technology may be used (e.g., an infrared light, an LED light) and each light emitting device may be positioned on any surface or part of the HMD device 1600.In various embodiments, for example, a light emitting device is positioned on the exterior of the HMD device 1600, as illustrated by device 1605 in FIGS.", "16 and 18.The light emitting device 1605 emits a light that is used as a marker by the camera device 115a when the HMD device 1600 is worn by a user in front of the camera device 115a.", "That is, the camera device 115a uses the emitted light to help track the movement, orientation and/or pose of the face of the user 105a (e.g., as described in connection with step 330 of FIG.", "3A.)", "The interior of the HMD device 1600 may also include a light emitting device.", "In various designs, for example, there is one or more infrared light emitting devices positioned in the back or interior of the HMD device 1600.One example location for the infrared light is illustrated in FIG.", "17, which shows the interior or rear of the HMD device 1600 i.e., the side of the HMD device that, when worn, is positioned over the eyes and flush against the face of the user.", "One or more light sources 1610 (e.g., infrared light sources) are positioned on the HMD device 1600 and arranged to illuminate the eyes of the user when the user wears the HMD device 1600.The infrared light sources assist in the tracking of particular facial features (e.g., gaze, eyelids, etc.)", "The sensor unit 1930 includes one or more sensors that are arranged to help track facial movements of a user who is wearing the HMD device.", "Any suitable sensor technology may be used, including but not limited to tracking cameras, pressure sensors, temperature sensors, mechanical sensors, motion sensors, light sensors and electrical sensors.", "In various embodiments, for example, there are one or more electromyography (EMG) and electrooculography (EOG) sensors positioned on the interior/back side of the HMD device.", "An example set of EMG sensors 1605 and EOG sensors is illustrated in FIG.", "17.In this example, the EMG sensors 1605 and the EOG sensors 1605a are situated on or within a cushion on the HMD device 1600.When the HMD device 1600 is worn, the cushion and the sensors 1605 are pressed flush against the eyebrows of the user.", "When the eyebrows move, the sensors 1605 detect the electrical impulses generated by the muscle movement.", "The HMD device 1600 then transmits this sensor data to the camera device 115a for processing, as described in steps 315, 320 and 325 of FIG.", "3A.", "Such EMG sensors may be arranged to detect motion in other parts of the face of a user as well.", "There may also be one or more light sensors mounted on the HMD device 1600.One such example is illustrated in FIGS.", "16 and 18.As shown in the figures, a light sensor 1610 is mounted on an exterior surface of the HMD device 1600.The light sensor 1610 is arranged to detect a level of ambient light around the HMD device 1600.The HMD device 1600 is arranged to transmit the light sensor data to an image processing device (e.g., camera device 115a or server 120 of FIG.", "1) using the network interface unit 1915, so that the data can be used to help determine how a tone or light level in a 3D model 405 should be adjusted (e.g., as described in step 340).", "The sensor unit 1930 may also include one or more cameras or other tracking devices that are arranged to track the movement of facial features that are covered by the HMD device 1600.In some embodiments, for example, the sensor unit 1930 includes one or more cameras that are arranged to track gaze, eye rotation, eyelid movement and/or other facial features that underlie the HMD device 1600 when the device is worn by a user.", "An example arrangement of such tracking devices (e.g., tracking cameras 1615) are shown in FIG.", "17.The display unit 1920 is any hardware or software used to display images, video or graphics to a user of the HMD device 1600.An example position for the display unit is illustrated in FIG.", "17.In the illustrated embodiment, when the user wears the HMD device 1600, the display unit 1920 is positioned directly over the eyes of the user.", "The display unit 1920 can use any suitable display and/or projection technology to show images to the user.", "In various embodiments, the display unit 1920 is arranged to provide the user with a virtual reality experience.", "That is, the HMD device 1600 completely covers the eyes of the user, therefore removing the user's ability to see his physical surroundings.", "Once the display unit 1920 is activated, the only thing the user is able to see are the graphics and images that the display unit 1920 generates.", "This can give the user the impression that he or she is an entirely different, virtual environment.", "In some designs, when the user turns his or her head, sensors in the HMD device 1600 detect the motion and cause the images to shift to give an impression that the user is actually physically in the simulated environment and can explore it just as the user would any real, physical environment (i.e., by turning one's head, peering around a corner, looking up and down an object, etc.)", "The display unit 1620 is further arranged to display the face of another HMD device user in real time, with (partially) simulated facial expressions, as described in step 385 of FIG.", "3B.", "Any known virtual reality display technology may be used in the display unit 1920.The power source 1940 includes any suitable hardware or software used to store energy or electrical power.", "The stored energy is used to power other components and operations of the HMD device 1600.Any suitable energy storage mechanism may be used.", "In some embodiments, for example, the power source is a battery.", "In other embodiments, the HMD device 1600 is powered through a wired connection to an external power source.", "The network interface unit 1915 includes any hardware or software suitable for enabling the HMD device 1600 to communicate with other devices (e.g., the camera device 115a, the server 120, another HMD device, etc.)", "over a network (e.g., a local network, network 125 of FIG.", "1, a wireless or wired network, etc.)", "In some embodiments, the network interface unit 1915 is arranged to transmit tracking and sensor data to the camera device 115a for processing (e.g., steps 320 and 335 of FIG.", "3A.)", "The network interface unit 1915 is also arranged to receive images and image data over the network 125 from another camera device and/or HMD device (e.g., step 385 of FIG.", "3B.)", "The network interface unit 1012 is arranged to transmit data and receive data using any suitable network (e.g., LAN, Internet, etc.)", "or communications protocol (e.g., Bluetooth, WiFi, NFC, IEEE 802.15.4, IEEE 802.11, etc.)", "The storage unit 1910 includes any hardware or software suitable for storing data or executable computer code.", "The storage unit 1910 can include but is not limited to a hard drive, flash drive, non-volatile memory, volatile memory or any other type of computer readable storage medium.", "Any operation or method for the HMD device (e.g., HMD device 110a/110b of FIG.", "1) that is described in this application (e.g., step 315 of FIG.", "3A, step 385 of FIG.", "3B, etc.)", "may be stored in the form of executable computer code or instructions in the storage unit 1910.The execution of the computer code or instructions by the processor unit 1905 causes the device 1600 to perform any of the aforementioned operations or methods.", "The HMD device control module 1935 is any hardware or software arranged to perform any of the operations or methods (e.g., step 315 of FIG.", "3A, step 385 of FIG.", "3B, etc.)", "described in this application that pertain to the HMD device (e.g., HMD device 110a/110b of FIG.", "1.)", "In various embodiments, the HMD device control module 1935 is arranged to cause the device 1600 to track facial features, render and display images received from another HMD device/camera device (e.g., steps 315 and 385).", "The HMD device 1600 may have a wide variety of different form factors, sizes, dimensions and configurations.", "One particular example implementation is shown in the FIGS.", "16-18.In the illustrated embodiment, for example, the HMD device 1600 includes a body 1640 with a frontside 1645 and a backside 1650.The body 1640 includes some or all of the electrical and computer components described above and shown in FIG.", "19.The frontside 1645 of the body 1640 is illustrated in FIG.", "18 and includes a frontal plate 1655.When the HMD device 1600 is worn by a user, the frontal plate 1655 and body 1640 completely cover and hide the eyes of the user.", "In various embodiments, the frontal plate 1655 and body 1640 thus entirely prevent any ambient light from reaching the eyes of the user.", "As a result, the HMD device 1600 is able to entirely control what the user sees.", "The backside 1650 of the HMD device 1600, which is illustrated in FIG.", "17, is designed to be placed flush against the face and over the eyes of the user.", "In the illustrated embodiment, the backside 1650 of the HMD device 1600 includes a cushion 1660 that surrounds or borders the display unit 1920.As previously discussed, the cushion may include various biometric sensors (e.g., EMG sensors 1605, EOG 1605a, etc.)", "and is designed to be pressed flush against the forehead or other portions of the face of the user when the HMD device 1600 is worn.", "The HMD device 1600 may also include various structures or mechanisms for firmly securing the HMD device 1600 to the face of a user.", "In the illustrated embodiment, for example, when a user wears the HMD device 1600, the device is secured to the face with a side strap 1665 that goes around the head, as illustrated in FIG.", "16.Another central strap 1670 extends from the top of the body 1640 of the HMD device 1600 over the top of the head.", "In this particular embodiment, one or more light emitting devices 1605 are mounted on a portion of this central strap.", "Such devices emit light that a camera device 115a can use to track the position of the head of the user.", "Additionally or alternatively, such devices may be placed in any suitable location on a surface of the HMD device 1600.Referring next to FIG.", "20, an imaging processing device 2000 according to a particular embodiment of the present invention will be described.", "In various embodiments, the imaging processing device 2000 is a camera device (e.g., the camera device 115a of FIGS.", "1 and 6), although the imaging processing device 2000 may also be any suitable device arranged to collect, generate, process and transmit images as described in the method 300 of FIGS.", "3A and 3B.", "That is, the imaging processing device 2000 may be any device that is arranged to perform some or all of the operations performed by the camera device 115a in the aforementioned method.", "Accordingly, in some embodiments, the imaging processing device 2000 is a camera device, a game console, a server (e.g., the server 120 of FIG.", "1), a computer, a smartphone a television and/or any other suitable computing device.", "The imaging processing device 2000 includes a processor unit 2005 that includes one or more processors, a storage unit 2010, an image processing device control module 2020, an optional sensor unit 2025 and a network interface unit 2015.The network interface unit 2015 includes any hardware or software suitable for enabling the imaging processing device 2000 to communicate with the HMD device (e.g., HMD device 110a/1600), the server 120 or other devices over a network as appropriate.", "In some embodiments, the network interface unit 2015 is arranged to obtain a 3D model 405, a background image 510, HMD device tracking data, camera/light sensor tracking data or other types of data from external sources (e.g., steps 305, 310, 320 and 335 of FIG.", "3A.)", "The network interface unit 2015 is also arranged to transmit image data to an HMD device 110a/110b/1600 over a network, so that the image data can be rendered and seen by a user of the HMD device (e.g., step 380 of FIG.", "3B.)", "The network interface unit 2015 is arranged to transmit data and receive data using any suitable network (e.g., LAN, Internet, etc.)", "or communications protocol (e.g., Bluetooth, WiFi, NFC, IEEE 802.15.4, IEEE 802.11, etc.)", "The storage unit 2010 is any hardware or suitable for storing data or executable computer code.", "The storage unit 2010 can include but is not limited to a hard drive, flash drive, non-volatile memory, volatile memory or any other type of computer readable storage medium.", "Any operation or method for the camera device (e.g., camera device 115a of FIG.", "1) that is described in this application (e.g., steps 305-310, steps 320-385 of FIGS.", "3A and 3B) may be stored in the form of executable computer code or instructions in the storage unit 2010.The execution of the computer code or instructions by the processor unit 2005 causes the device 2000 to perform any of the aforementioned operations or methods.", "The image processing device control module 2020 is any hardware or software arranged to perform any of the operations or methods (e.g., steps 305-310, steps 320-385 of FIGS.", "3A and 3B) described in this application that pertain to the camera device 115a.", "In various embodiments, the image processing device control module 2020 is arranged to cause the device to obtain a 3D model, a background image, HMD device and/or camera device tracking data, render a model, obtain a patch image, merge the patch image and a facial/background image, merge the resulting composite image with a background patch and transmit the composite image (e.g., steps 305-380 of FIGS.", "3A and 3B.)", "The sensor unit 2025 is an optional unit that is included if the image processing device 2000 is, for example, a camera/monitoring device (e.g., the camera device 115a of FIG.", "1.)", "The sensor unit 2025 includes any hardware or software arranged to help track or monitor facial features of a user who wearing an HMD device.", "In various embodiments, for example, the sensor unit 2025 includes one or more cameras that are arranged to track a light emitted by a device on the HMD device.", "In still other embodiments, the camera(s) are used to track the general orientation or pose of the head of a user and/or particular features on the face of the user (e.g., the position of the lips.)", "Some implementations of the sensor unit 2025 include one or more light sensors arranged to track the ambient light level, or the light level on a nearby object or user (e.g., as described in connection with step 330 of FIG.", "3A.)", "The image processing device 2000 then analyzes the images and sensor data and processes them (e.g., as described in steps 330, 335 and 340 of FIG.", "3A.)", "Any of the methods or operations described herein can be stored in a tangible computer readable medium in the form of executable software code.", "The code can then be executed by one or more processors.", "The execution of the code causes a corresponding device (e.g., an image processing device 2000, a server 120, a camera device 115a, an HMD device 110a/1600, etc.)", "to perform the described operations.", "The above methods and arrangements relate to the generation of a patch image.", "In some of the examples described above, the patch image corresponds to only a portion of the face of a user.", "However, in various implementations, the patch image corresponds to other parts of the face or body, or can correspond to or indicate any part of the body or a portion of any object or image.", "The above methods and arrangements also describe techniques for merging a patch image and a facial/background image.", "In some of the aforementioned examples, the facial/background image is an image captured using a (video) camera e.g., each facial/background image is a video frame of a video taken of the user who is wearing an HMD device.", "The patch image is based on a rendered model of at least a portion of the head or face of the user.", "The patch image and the facial/background image are merged, forming a composite image that is partially or mostly a video frame.", "A portion of the composite image is the patch image, which is a pre-rendered model of a portion of the face of the user and is not a photograph or video of the user.", "It should be appreciated, however, that the patch image and the facial/background image may be based on a wide variety of different types of media and formats.", "For example, in some embodiments, the facial/background image is not a frame of a live video feed, but instead is also a rendered three-dimensional model (which in turn may have been generated based on a video or a three dimensional scan of a user and/or his or her surroundings.)", "The techniques described herein can be used to merge a patch image (e.g., a rendered model of a user's eyes or eye region) with the facial/background image (e.g., a rendered model of at least other portions of the user's face or head.)", "In some of the aforementioned examples, an HMD device is described that covers the eyes of a user.", "A facial/background image is taken that captures the user, and a patch image is merged into the facial/background image.", "This merger replaces the HMD device in the image with simulated facial features.", "However, it should be appreciated that the techniques of this application may also be applied to any process in which one image is “patched” with another, and is not necessarily limited only to the specific examples of patch images and HMD devices described above.", "By way of example, in some implementations, the HMD device does not completely cover the eyes of a user and/or may cover other parts of the face or body of a user.", "The patching techniques described herein may be used to generate one or more patch images based on sensors in the HMD device that track features underlying the HMD device.", "Based on such sensor data, a patch image may be generated and merged with a facial/background image of the user and the HMD device (e.g., generally as described in the steps of method 300 of FIGS.", "3A and 3B.)", "Although only a few embodiments of the invention have been described in detail, it should be appreciated that the invention may be implemented in many other forms without departing from the spirit or scope of the invention.", "For example, the present application and figures describe various methods (e.g., methods of FIGS.", "3A and 3B) that perform particular operations.", "It should be appreciated that in some embodiments, one or more of these operations/steps may be modified, reordered and/or deleted.", "Additionally, some figures, such as FIGS.", "1 and 16-20, describe devices that contain various components.", "It should be noted that in some embodiments, one or more of these components may be merged together.", "In still other embodiments, one or more components may be separated into a greater number of components.", "The features of one component may be transferred to another and/or modified as appropriate.", "Each device may have additional components beyond what is shown in the corresponding figure.", "Therefore, the present embodiments should be considered illustrative and not restrictive and the invention is not to be limited to the details given herein." ] ]
Patent_15874318
[ [ "Movable Cooking Appliance", "A movable cooking appliance comprises a structure which is adapted to be placed on a kitchen worktop appliance or inside a cooking oven appliance and includes a heating element and releasable connector assembly for making electrical connection with power supply connectors.", "The heating element is an induction heating element and an electronic driving unit is mounted on the appliance.", "The releasable connector assembly comprising a plug connector having a plurality of terminals designed in order to provide a disconnection signal to the electronic unit before the power supply connectors are fully extracted." ], [ "1.A method of controlling a cooking appliance including a cooking unit having an electronic driving unit, an induction tray configured to be removably attached to the cooking unit and having an induction heating element, and a connector assembly interconnecting the induction tray to the cooking unit to provide power to and control the induction tray, wherein the connector assembly includes a female connector assembly, including a plurality of female terminals, attached to one of the induction tray or the cooking unit and a male connector assembly, including a plurality of male terminals, attached to another one of the induction tray or the cooking unit, said method comprising: when detaching the induction tray from the cooking unit by removing the plurality of male terminals from respective ones of the plurality of female terminals, causing a power source to be disconnected from the induction tray through the male and female connector assemblies before the plurality of male terminals are fully removed from the plurality of female terminals, with at least one male terminal of the plurality of male terminals being a temperature sensor terminal electrically connected to a temperature sensor of the induction heating element, with the at least one male terminal being different in length than other ones of the plurality of male terminals such that the at least one male terminal is removed from at least one female terminal of the plurality of female terminals to provide a disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals, and with one of the plurality of male terminals acting on a switch to provide a disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "2.The method of claim 1, wherein various ones of the plurality of male terminals vary in length so as to be removed from respective ones of the plurality of female terminals at varying times to provide the disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "3.The method of claim 2, wherein the plurality of male terminals includes at least three sets of terminals with distinct lengths so as to be removed from respective ones of the plurality of female terminals at three different times to provide the disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "4.A method of controlling a cooking appliance including a cooking unit having an electronic driving unit, an induction tray configured to be removably attached to the cooking unit and having an induction heating element, and a connector assembly interconnecting the induction tray to the cooking unit to provide power to and control the induction tray, wherein the connector assembly includes a female connector assembly, including a plurality of female terminals, attached to one of the induction tray or the cooking unit and a male connector assembly, including a plurality of male terminals, attached to another one of the induction tray or the cooking unit, said method comprising: when detaching the induction tray from the cooking unit by removing the plurality of male terminals from respective ones of the plurality of female terminals, causing a power source to be disconnected from the induction tray through the male and female connector assemblies before the plurality of male terminals are fully removed from the plurality of female terminals, with at least one male terminal of the plurality of male terminals being a temperature sensor terminal electrically connected to a temperature sensor of the induction heating element, and with the at least one male terminal being different in length than other ones of the plurality of male terminals such that the at least one male terminal is removed from at least one female terminal of the plurality of female terminals to provide a disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "5.The method of claim 4, wherein the at least one male terminal is shorter in length than the other ones of the plurality of male terminals such that removing the at least one male terminal from at least one female terminal of the plurality of female terminals provides the disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "6.The method of claim 4, wherein various ones of the plurality of male terminals vary in length so as to be removed from respective ones of the plurality of female terminals at varying times to provide the disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "7.The method of claim 6, wherein the plurality of male terminals includes at least three sets of terminals with distinct lengths so as to be removed from respective ones of the plurality of female terminals at three different times to provide the disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "8.The method of claim 4, further comprising: when attaching the induction tray to the cooking unit, inserting another male terminal of the plurality of male terminals into at least one female terminal of the plurality of female terminals to establish a ground connection for a sensor circuit, the sensor circuit including the temperature sensor of the induction heating element.", "9.The method of claim 4, further comprising: when attaching the induction tray to the cooking unit, inserting first and second sensor terminals, first and second power terminals and a ground terminal of the plurality of male terminals into respective ones of the plurality of female terminals.", "10.The method of claim 9, wherein the first and second sensor terminals are shorter in length than the first and second power terminals, and the first and second power terminals are shorter in length than the ground terminal such that, when attaching the induction tray to the cooking unit, the ground terminal is inserted into the female connector assembly before the first and second power terminals, and the first and second power terminals are inserted into the female connector before the first and second sensor terminals.", "11.A method of controlling a cooking appliance including a cooking unit having an electronic driving unit, an induction tray configured to be removably attached to the cooking unit and having an induction heating element, and a connector assembly interconnecting the induction tray to the cooking unit to provide power to and control the induction tray, wherein the connector assembly includes a female connector assembly, including a plurality of female terminals, attached to one of the induction tray or the cooking unit and a male connector assembly, including a plurality of male terminals, attached to another one of the induction tray or the cooking unit, said method comprising: when detaching the induction tray from the cooking unit by removing the plurality of male terminals from respective ones of the plurality of female terminals, causing a power source to be disconnected from the induction tray through the male and female connector assemblies before the plurality of male terminals are fully removed from the plurality of female terminals, with one of the plurality of male terminals acting on a switch to provide a disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "12.The method of claim 11, wherein the one of the plurality of male terminals acting on the switch includes the one of the plurality of male terminals acting on a mechanical switch.", "13.The method of claim 11, wherein the one of the plurality of male terminals acting on the switch includes the one of the plurality of male terminals acting on a proximity switch.", "14.The method of claim 11, wherein the one of the plurality of male terminals is different in length than other ones of the plurality of male terminals so as to disengage from the switch and provide the disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "15.The method of claim 14, wherein the one of the plurality of male terminals is longer in length than other ones of the plurality of male terminals so as to disengage from the switch and provide the disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "16.The method of claim 11, wherein various ones of the plurality of male terminals vary in length so as to be removed from respective ones of the plurality of female terminals at varying times to provide the disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "17.The method of claim 16, wherein the plurality of male terminals includes at least three sets of terminals with distinct lengths so as to be removed from respective ones of the plurality of female terminals at three different times to provide the disconnection signal to the electronic driving unit before all of the plurality of male terminals are fully removed from their respective plurality of female terminals.", "18.The method of claim 11, further comprising: when attaching the induction tray to the cooking unit, inserting first and second sensor terminals, first and second power terminals and a ground terminal of the plurality of male terminals into respective ones of the plurality of female terminals.", "19.The method of claim 18, wherein the first and second sensor terminals are shorter in length than the first and second power terminals, and the first and second power terminals are shorter in length than the ground terminal such that, when attaching the induction tray to the cooking unit, the ground terminal is inserted into the female connector assembly before the first and second power terminals, and the first and second power terminals are inserted into the female connector before the first and second sensor terminals." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention is mainly focused on the problem of assuring safe and reliable insertion and extraction of a releasable connector means for connecting an induction tray, for instance, into an oven cavity.", "The present invention also addresses a tray including an induction element being plugged into or unplugged from the socket of a power supply connector means located inside an oven cavity in a safe manner.", "It is therefore an object of the present invention to provide a solution to the above concerns.", "The present invention is focused on the design of a connector that is to be used to connect an induction tray into a socket of an oven cavity or other type of support used for the tray.", "In a preferred embodiment of the invention, the connector has five male terminals, including two for the power connection (i.e., supplying an induction heating coil), two for the temperature sensor connection (that allows a reading of temperature sensor placed in the coil centre of the induction heating element for safety reasons) and one a ground connection (that guarantees electrical safety for the user).", "The design of the connector according to the invention enables a safer and more reliable insertion and extraction of the male plug of the induction heating tray whenever the user uses it as an accessory inside an oven or on a kitchen worktop." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application represents a continuation application of U.S. application Ser.", "No.", "13/079,040, titled “Movable Cooking Appliance” and filed on Apr.", "4, 2011, pending.", "The entire content of this application is incorporated herein by reference.", "BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to movable cooking appliances or cooking trays including structure which is adapted to be placed on a worktop of kitchen furniture or inside a cooking oven (collectively referred to as a cooking unit), and includes a heating element and releasable connector means for making electrical connection with power supply connector means.", "With the term “movable” we mean any kind of cooking and heating appliance which can be plugged or unplugged to a fixed support, whatever such support is.", "Description of the Related Art The above kind of cooking appliances or cooking accessories are well known in the art.", "An example is shown in U.S. Pat.", "No.", "5,272,317.With the known appliances the heating element is an electrical resistance heater connected, for instance, to a shelf or tray adapted to be introduced into an oven cavity.", "The use of electrical resistance heaters has been replaced by more efficient induction heating elements which, despite a higher complexity and cost (mainly due to the complex electronic driving circuit), allow the induction heating elements to reach a desired temperature in a shorter time and with a lower energy consumption.", "One compromise would be to design an induction cooking appliance or accessory without a built-in electronic driving circuit, and integrating this in kitchen furniture or cooking appliance (such as a traditional oven or an induction oven).", "By adopting this solution it is important to assure a safe and reliable connection between the “fixed” electronic driving circuit and the movable induction cooking appliance or accessory.", "Prior art connectors that are in use generally have terminals with equal length.", "The design of these connectors doesn't implement any further safety feature that guarantees power supply cut-off when the user is extracting the removable tray with an induction heater while the tray is working.", "This abnormal procedure may happen during the use of the oven and this can cause a potential risk of electric arcing at the power terminals and potential breakdown of the insulated gate bipolar transistor (IGBT) associated with the electronic driving circuit of the heating element.", "SUMMARY OF THE INVENTION The present invention is mainly focused on the problem of assuring safe and reliable insertion and extraction of a releasable connector means for connecting an induction tray, for instance, into an oven cavity.", "The present invention also addresses a tray including an induction element being plugged into or unplugged from the socket of a power supply connector means located inside an oven cavity in a safe manner.", "It is therefore an object of the present invention to provide a solution to the above concerns.", "The present invention is focused on the design of a connector that is to be used to connect an induction tray into a socket of an oven cavity or other type of support used for the tray.", "In a preferred embodiment of the invention, the connector has five male terminals, including two for the power connection (i.e., supplying an induction heating coil), two for the temperature sensor connection (that allows a reading of temperature sensor placed in the coil centre of the induction heating element for safety reasons) and one a ground connection (that guarantees electrical safety for the user).", "The design of the connector according to the invention enables a safer and more reliable insertion and extraction of the male plug of the induction heating tray whenever the user uses it as an accessory inside an oven or on a kitchen worktop.", "BRIEF DESCRIPTION OF THE DRAWINGS Further advantages and features according to the present invention will be clear from the following detailed description, with reference to the attached drawings in which: FIG.", "1 is a schematic view of an oven according to the present invention; FIG.", "2 is a schematic view detailing the male and female terminals of a plug connector of the oven of FIG.", "1, according to a first embodiment of the invention and in a first configuration of use; FIG.", "3 is a schematic view similar to FIG.", "2, showing the terminals in a second configuration of use; FIG.", "4 is a schematic view similar to FIG.", "2, showing the terminals in a third configuration; FIG.", "5 is a schematic view similar to FIG.", "2, showing the terminals in a fourth configuration; FIG.", "6 is a schematic view detailing the male and female terminals of the plug connector an oven of FIG.", "1, according to a second embodiment of the invention; FIG.", "7 is a variant of the embodiment shown in FIG.", "6; FIG.", "8 is a schematic view detailing the male and female terminals of a plug connector of the oven of FIG.", "1, according to a third embodiment of the invention and in an unplugged configuration; FIG.", "9 is a schematic view similar to FIG.", "8 in a plugged configuration; FIG.", "10 is a schematic view detailing the male and female terminals of a plug connector according to a fourth embodiment of the present invention; FIG.", "11 is a schematic view of the male terminals of a plug connector in accordance with a further embodiment of the present invention; FIG.", "12 is a schematic view of the male terminals of a plug connector in accordance with yet a further embodiment of the present invention; FIG.", "13 is a schematic view detailing the male and female terminals of a plug connector of the oven of FIG.", "1, according to another embodiment of the invention, in a partially unplugged position; and FIG.", "14 is a schematic view similar to FIG.", "13, in a plugged position.", "DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS With reference to the drawings, an induction oven having a cabinet 10 is shown in FIG.", "1, the oven cabinet 10 defining a cooking cavity 10a where an induction tray 12 can be inserted and pulled out.", "The tray 12 has a double layer main body structure made of non-ferromagnetic material, such as aluminium, and includes an embedded induction heating element or coil (indicated at 36 in FIGS.", "11 and 12) with a temperature sensor (depicted at 34 in FIG.", "11).", "On a rear side 12a of the tray 12 there is a plug connector 14 for the electrical connection of tray 12 with a socket connector 16 placed on a rear wall 11 of the oven cavity 10a.", "In the following, we indicate with reference C the overall power connector assembly of the present invention, including the plug or male connector 14 supported by the tray 12 and the socket or female connector 16 supported by the oven.", "As noted previously, with known connectors, the design is not able to provide good safety as it doesn't implement any extra feature which lets the power board cut off the power before male plug extraction.", "Because of this, extraction of the induction tray 12 without cutting off the power supply to tray 12 may cause safety problems for the customer and reliability problems for the oven.", "According to a first embodiment of the present invention depicted in FIG.", "1, the design of connector C presents assemblies of five male terminals and associated female terminals which make up a total of five connections.", "Two sets of the terminals 18 provide power connections, two sets of the terminals 20 are for the temperature sensor connection and one set including terminal 22 is for the ground connection.", "As shown in the embodiment of FIG.", "2, the ground terminal 22 has the greatest length, the sensor terminals 20 (equal to each other in length) are the shortest ones and the power terminals 18 (equal to each other in length) have an intermediate length between the lengths of the ground terminal 22 and of the sensor terminals 20.This design enables the ground terminal 22 to connect first during insertion of plug 14, and to disconnect last during extraction of the plug 14, guaranteeing safety electrical discharge through ground terminal 22 in case there might be a discharge between induction coil 36 (again depicted in FIGS.", "11 and 12) and aluminium plates of the tray 12, thus eliminating the electrical risks for the user.", "FIGS.", "2, 3, 4 and 5 show different positions of the male-female connector C: FIG.", "2 shows a complete insertion of the plug 14 with all terminals having complete electrical contact; FIG.", "3 shows a partial extraction of male plug 14 with ground 22 and power terminals 18 yet in contact; FIG.", "4 shows a configuration in which only ground 22 remains in contact; and FIG.", "5 shows full extraction, i.e., all terminals are not in contact with socket connector 16.As illustrated in FIG.", "3, during extraction of the male plug 14, the sensor terminals 20 lose electrical contact first since they have the shortest length.", "Once this happens, a power board indicated at P senses the connection as an open-circuit and automatically cuts off the power to the tray 12 before the power terminals are actually disconnected (as they are still in contact with the female sockets due to their longer terminals).", "According to a second embodiment of the invention depicted in FIG.", "6, inside the female plug 16 there is a switch 24 that is electrically closed by the ground plug 22 when inserting the male plug 14.This circuit is connected to power board P of the oven.", "The switch 24 can be of any kind.", "For instance, it can be a mechanical switch (that is in physical contact with the terminals) or it can be a proximity switch (that doesn't need a physical contact), such as a reed switch 40 shown in FIGS.", "13 and 14.This switch mechanism 24 can be short-circuited and open-circuited, distinguishing the cases between complete male plug insertion and not complete insertion, respectively.", "As can be seen in FIG.", "6, the extraction of the male plug 14 from the female socket 16 including mechanical switch 24 causes the opening of the circuit, sending therefore a signal to the power board P to interrupt the power supply to the tray 12 before the power terminals 18 are disconnected.", "It is clear that the position of the mechanical switch 24 (in FIG.", "6 it is positioned close to the ground terminal 22) can vary and can be applied to any other terminal.", "However, it must be placed in a way that the mechanical switch 24 opens before the power terminals 18 are completely extracted, in order to allow the power board P to cut off the power before the connector 14 is fully extracted from female plug 16 (safety power cut-off).", "FIG.", "7 shows a connector C which is slightly different from the one shown in FIG.", "6, and where the length of the terminals 18, 20 and 22 are similar to the one shown in FIG.", "2.In this embodiment, the ground terminal 22 remains the longest for safety precaution as already explained.", "If the switch 24 is a reed switch, the terminal involved has to be made of permanent magnetic material.", "A further embodiment of the present invention is shown in FIGS.", "8 and 9, where the male plug 14 has terminals of identical lengths and a female socket 16 with a mechanical switch mechanism 26.This mechanism 26 comprises a metal piece 26a hinged to one of the temperature sensor female terminals 20 via a spring 26b.", "When the male plug 14 is not inserted (FIG.", "8), the metal piece 26a contacts both terminals 20 of sensor 34, short-circuiting them.", "The power board P senses that temperature sensor terminals 20 are short circuited and it doesn't supply power to induction tray 12.Otherwise, when the male plug 14 is inserted (FIG.", "9), the metal piece 26a doesn't contact both terminals 20 and therefore the power board P supplies power to the induction tray 12 as it senses that the male plug 14 is fully inserted and there is no safety issue.", "The embodiment shown in FIG.", "10 has all five terminals 18, 20, 22 mentioned above at equal length, and it presents in addition a sixth terminal 30b (associated with an additional plug 30a) which is made of another material such as ceramic or plastic and which has a greater length than other terminals.", "This sixth terminal 30b turns on and off the electrical connection by a mechanical switch 32 during insertion and extraction, respectively.", "The embodiment shown in FIG.", "11 has the aim of reducing the number of terminals or to avoid the need of adding extra sensor terminals.", "Reducing the number of terminals would provide a cost saving and easier connection in addition to space saving inside the oven.", "More specifically, the male plug 14 in this embodiment has four terminals consisting of one ground terminal 22, two power terminals 18 and one single terminal 20 for a temperature sensor indicated with reference 34 in FIG.", "11, while the induction coil is schematically indicated with reference 36.According to this embodiment, in order to save material and space, it is possible to use the ground terminal 22 as the second sensor terminal.", "This embodiment has the ground terminal 22 with the greatest length, the sensor single terminal 20 with the shortest length and the power terminals 18 in between these two lengths as in the first above embodiment.", "The power board P should be designed for reading the sensor signal with an isolated signal-conditioning circuit, as it is referenced with the oven ground which is isolated with respect to the power supplier in any appliance by default.", "In the further embodiment shown in FIG.", "12, the five terminals of the previous embodiment 18, 20 and 22 are maintained and an extra temperature sensor 38 is added that will still use the ground as a reference level.", "This can also be extended to three readings using three terminals and a ground terminal, and so on.", "Increasing the number of temperature readings enables a better control of the induction heater temperature, and using the ground terminal provides a savings from the number of terminals needed.", "The power board P should be designed for reading the sensor signal with an isolated signal-conditioning circuit in this embodiment, as well.", "Even if in the above embodiments the plug connector 14 is shown as supported by the induction tray 12, it is clear that such a plug connector can be supported by the rear oven wall 11 and the socket connector 16 can be supported by the tray 12 as well." ] ]
Patent_15874320
[ [ "ANTIMICROBIAL COMPOUNDS AND COMPOSITIONS, AND USES THEREOF", "A method of enhancing the growth of an animal is provided.", "The method includes causing the animal to ingest or absorb an effective amount of one or more Fe III complex compounds, including but not limited to Fe III complexes comprising ligands bound to the iron centre selected from amino acids or α-hydroxy acids, o-hydroxy benzoic acids or pyridine-2-carboxylic acids, such as ferric quinate, ferric tyrosine, ferric DOPA and ferric phenylalanine.", "Compounds which are structural and/or functional variants, derivatives and/or analogs of the foregoing compounds, as further described herein are also disclosed.", "Methods for inhibiting, reducing, or preventing biofilm formation or buildup on a surface; the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments; disinfecting surfaces, potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, to anti-microbial agents are also provided." ], [ "1.A composition comprising an effective amount of a compound to inhibit bacterial biofilm formation in a subject, wherein the compound is an Fe III complex having the structure of: Formula A: or a salt and/or hydrate thereof, wherein: X, X1 and X2 are independently selected from the group consisting of NH2, OH, CO2—, CO2H, OR3, NR3H, NR3R4, R3ONO2, R3NO2, SH, SR3, and X, X1 and X2 may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; Y, Y1 and Y2 are independently selected from the group consisting of O, NH, NH2, NR3, NR3R4, SH, OR3, OH, and Y, Y1 and Y2 may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; Z, Z1 and Z2 are independently selected from the group consisting of: O, S, NH, NR3, and Z, Z1 and Z2 may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; R, R′, R1, R1′, R2, and R2′ are independently selected from the group consisting of H, CH3, CH2SH, CH2CO2H, CH2CH2CO2H, CH2C6H5, CH2C3H3N2, CH(CH3)CH2CH3, (CH2)4NH2, CH2CH(CH3)2, CH2CH2SCH3, CH2CONH2, (CH2)4NHCOC4H5NCH3, CH2CH2CH2, CH2CH2CONH2, (CH2)3NHC(NH)NH2, CH2OH, CH(OH)CH3, CH2SeH, CH(CH3)2, CH2C8H6N, CH2C6H4OH, and CH2C6H3(OH)2, and R, R′, R1, R1′, R2, and R2′ may all be the same or they may all be different, or, alternatively, up to five may be the same and one or more may be different; or any relevant pair of R and R′, R1 and R1′, and R2 and R2′ are linked to form a substituted or unsubstituted cycloalkyl ring group; and R3 and R4 can independently be alkyl, alkenyl, alkynyl, phenyl, aryl, halo- and hydroxy-substituted radicals, hydroxyl radicals, nitrogen-substituted radicals, oxygen-substituted radicals, or hydrogen.", "2.The composition of claim 1, wherein R3 and R4 are independently C1-4 alkyl, C1-4 alkenyl, phenyl or benzyl, which latter four groups are optionally substituted by one or more halo or hydroxyl groups.", "3.The composition of claim 1, wherein one, two or all three of the ligands bound to the iron center are selected from amino acids or α-hydroxy acids.", "4.The composition of claim 1, comprising an effective amount of a compound to inhibit bacterial biofilm formation in a subject, the compound having a structure selected from the group consisting of: 5.The composition of claim 3, wherein one, two or all three of the ligands bound to the iron center are α-hydroxy acids.", "6.The composition of claim 1, wherein the one or more compounds are in combination with one or more coccidiostats, antimicrobial agents and one or more excipients, carriers and/or additives.", "7.The composition of claim 1, in a unit dosage form comprising one or more compounds of claim 1 in an amount of up to, or at least, about 1 ng, 10 ng, 50 ng, 100 ng, 500 ng, 1 μg, 10 μg, 50 μg, 100 μg, 500 μg, 1 mg, 10 mg, 100 mg, 500 mg, 1 g, 2 g, 3 g, 4 g, or 5 g. 8.The composition of claim 7, selected from the group consisting of a dietary product, an animal feed, disinfecting product, a human or animal dietary supplement, drinking product, a pharmaceutical or veterinary product, a cosmetic; a food production apparatus, a food processing apparatus, and a coating, wherein the one or more compounds are optionally conjugated to hydroxyapatite.", "9.The composition of claim 8, wherein the concentration of the one or more compounds is between a range of about 1 μM to about 1M.", "10.The composition of claim 8, wherein the composition is an animal feed, and the one or more compounds are in an amount between 0.001 to 20 g per Kg of feed.", "11.The composition of claim 8, wherein the composition is drinking water and the concentration of the one or more compounds is within the range of 0.002 to 15 g/L.", "12.The composition of claim 8, in the form of an emulsion, lotion, cream, ointment, wound dressing, patch, salve, gel, tablet, solution, suspension, foam, a spray, an aerosol, or imbibed into a suitable cloth.", "13.The composition of claim 1, wherein the composition is an animal feed, and wherein the compound is a complex of Fe III and tyrosine.", "14.The composition of claim 1, wherein R, R′, R1, R1′, R2, and R2′ are independently selected from the group consisting of H, CH3, CH2SH, CH2CO2H, CH2CH2CO2H, CH2C6H5, CH(CH3)CH2CH3, (CH2)4NH2, CH2CH(CH3)2, CH2CH2SCH3, CH2CONH2, (CH2)4NHCOC4H5NCH3, CH2CH2CH2, CH2OH, CH(OH)CH3, CH2SeH, CH(CH3)2, CH2C8H6N, CH2C6H4OH, and CH2C6H3(OH)2, and optionally, wherein the compound is not FeQ, FeTyr or FeDOPA." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>A biofilm is an accumulation of microorganisms (bacteria, fungi, and/or protozoa, with associated bacteriophages and other viruses) embedded in a polysaccharide matrix and adherent to solid biological or non-biotic surfaces.", "Biofilms are medically important, accounting for over 80 percent of hospital-acquired microbial infections in the body.", "Examples include infections of the: oral soft tissues, teeth and dental implants; middle ear; gastrointestinal tract; urogenital tract; airway/lung tissue; eye; urinary tract prostheses; peritoneal membrane and peritoneal dialysis catheters, indwelling catheters for hemodialysis and for chronic administration of chemotherapeutic agents (Hickman catheters); cardiac implants such as pacemakers, prosthetic heart valves, ventricular assist devices, and synthetic vascular grafts and stents; prostheses, internal fixation devices, percutaneous sutures; and tracheal and ventilator tubing.", "The microorganisms tend to be far more resistant to antimicrobial agents and to be particularly difficult for the host immune system to render an appropriate response.", "Several bacterial pathogens have been shown to associate with, and in some cases, grow in biofilms, including Legionella pneumophila, S. aureus, Listeria monocytogenes, Campylobacter spp., E. coli O157:H7, Salmonella typhimurium, Pseudomonas, Vibrio cholerae, S. epidermidis, E. faecalis , and Helicobacter pylori.", "Biofilms are remarkably difficult to treat with antimicrobials.", "Antimicrobials may be readily inactivated or fail to penetrate into the biofilm.", "In addition, bacteria within biofilms have increased (up to 1,000-fold higher) resistance to antimicrobial compounds, even though these same bacteria are sensitive to these agents if grown under planktonic conditions.", "In addition, bacteria embedded within biofilms are resistant to both immunological and non-specific defense mechanisms of the body.", "Contact with a solid surface triggers the expression of a panel of bacterial enzymes, which catalyze the formation of sticky polysaccharides that promote colonization and protection.", "The structure of biofilms is such that immune responses may be directed only at those antigens found on the outer surface of the biofilm, and antibodies and other serum or salivary proteins often fail to penetrate into the biofilm.", "In addition, phagocytes are unable to effectively engulf a bacterium growing within a complex polysaccharide matrix attached to a solid surface.", "This causes the phagocyte to release large amounts of pro-inflammatory enzymes and cytokines, leading to inflammation and destruction of nearby tissues.", "Conventional therapy is characteristically ineffective against biofilms, as the minimum inhibitory concentration (MIC) of antimicrobial agents has been shown to be 10 to 1000 fold greater than for planktonic organisms (Hoiby, et al., Int J Antimicrob Agents, 35(4):322-32 (2010).", "It is an object of the present invention to provide compositions and methods for inhibiting or preventing biofilm formation or promoting biofilm dissolution from surfaces of interest.", "It is still an object of the present invention to provide methods for reducing the transmission of pathogens in biofilm.", "It is a further object of the present invention to provide methods to treat antibiotic resistant bacteria.", "It is yet a further object to provide compositions to improve growth performance." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present inventors have identified a class of compounds, as described further below in Section III.A of this application, that have surprisingly been found to provide a broad range of activity, particularly against a diverse array of bacteria.", "The present invention provides numerous uses for, and methods involving, the compounds, particularly in the formation of compositions.", "The present invention also provides compositions, articles and products comprising one or more of the compounds, as described further below.", "The present invention also provides products produced by the application of the numerous uses and methods of the present invention, as well as downstream products produced therefrom.", "In one embodiment, the present invention provides compounds as described further below in Section III.A of this application and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for inhibiting, reducing, or preventing biofilm formation or buildup on a surface or to removing, dispersing, reducing, or eradicating biofilm on a surface.", "Accordingly, compositions for inhibiting, reducing, or removing biofilm buildup in a subject and/or on an article or other item are provided.", "An exemplary compounds and composition include an effective amount of one or more compound selected from Ferric Quinate (Fe-QA, also referred to herein as FeQ), and ferric complexes with L-tyrosine (Fe-Tyr), L-DOPA (Fe-DOPA), L-phenylalanine (Fe-Phe) and hydrates, salts, or derivatives thereof.", "See Formulas IX, VIII and VII, as defined further below, respectively.", "The compositions are effective against biofilms produced by a wide range of microbial species including, without limitation, S. epidermidis, E. faecalis, E. coli, S. aureus, Campylobacter spp.", "H. pylori and Pseudomonas , alone, or in combination.", "In an embodiment, an article or product, including medical devices having on the surface or dispersed therein one or more of the compounds as described further below in Section III.A of this application, or composition comprising the one or more compounds, for example of Formula IX (Fe-QA, or also referred to as FeQ), Formula VII (Fe-DOPA also referred to as FeDOPA) and Formula VIII (Fe-Tyr), or Fe-Phe, are prepared to prevent or reduce the formation of a biofilm on the article, or product, such as to prevent or reduce the formation of a biofilm on the medical device after implantation.", "The surface may be a biological surface (such as a surface of a living human, animal or plant surface, or the surface of a dead or harvested animal or plant), or a non-biological surface including for example, plastics, polymers, biomaterials, and metals.", "The present invention also provides products treated according to this embodiment.", "In another embodiment, the invention provides compounds as described further below in Section III.A of this application and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments.", "In a further embodiment, the invention also relates to compounds and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for disinfecting surfaces, both in biological and non-biological environments, and products that have been coated with, or treated by, one or more of the compounds and/or compositions of the present invention.", "In another embodiment, the invention also relates to compounds and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for potentiating the effects of one or more antibiotics, increasing the sensitivity of bacteria (including antibiotic-resistant bacteria) to one or more antibiotics, and also to reversing antibiotic resistance in bacteria.", "In yet another embodiment, the invention also relates to compounds and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for enhancing the growth of animals and their efficiency of feed utilization, in particular by oral administration of feed and drink compositions.", "Also provided are methods of treating microbial infections in a subject by inhibiting, reducing, or removing biofilm buildup in the subject and methods for treating subjects with microbial infections that are resistant to antibiotics.", "One method includes administering to the subject an effective amount of one or more compounds as described further below in Section III.A of this application, including but not limited to compounds according to Formula A or B as described therein, one or more compounds that bind to major outer membrane proteins (MOMPs) or FlaA of Campylobacter , a mimetic or synthetic human histo-blood group antigen or a synthetic sugar.", "In one embodiment, the method includes administering to the subject an effective amount of a compound represented by Formula I, Formula II, Formula III, Formula IV, Formula V, and Formula VI.", "In a preferred embodiment, the method includes administering to the subject an effective amount of a compound represented by Formula IX (ferric quinate, Fe-QA also designated as FeQ), Formula VII (Fe-DOPA), Formula VIII (Fe-Tyr), or Fe-Phe, and hydrates, salts, or derivatives thereof.", "In another preferred embodiment, the one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as descried therein, one or more compounds of Formula I-IX orX-XIV, or compositions comprising one or more of said compounds, may be used to cure, treat, or prevent symptoms of or associated with a variety of conditions as described herein, such as arterial damage, gastritis, urinary tract infections, biliary tract infections, pyelonephritis, cystitis, sinus infections, ear infections, otitis media, otitis externa, leprosy, tuberculosis, conjunctivitis, bloodstream infections, benign prostatic hyperplasia, chronic prostatitis, lung infections including chronic lung infections of humans with cystic fibrosis, osteomyelitis, catheter infections, bloodstream infections, skin infections, acne, rosacea, dental caries, periodontitis, gingivitis, nosocomial infections, arterial damage, endocarditis, periprosthetic joint infections, open or chronic wound infections, venous stasis ulcers, diabetic ulcers, arterial leg ulcers, pressure ulcers, endocarditis, pneumonia, orthopedic prosthesis and orthopedic implant infections, peritoneal dialysis peritonitis, cirrhosis, and any other acute or chronic infection that involves or is associated with a biofilm.", "In a preferred embodiment for treating antibiotic- (or other antimicrobial-) resistant microbial infections, the method includes administering to the subject an effective amount of an antibiotic or other antimicrobial agent (which may be the antibiotic/antimicrobial to which the microbial infection is resistant) and an effective amount of one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, or one or more compounds represented by any of Formulae I to XIV, such as Formula I, Formula II, Formula III, Formula IV, Formula V, and Formula VI or, preferably, an effective amount of one or more compound represented by Formula IX, Formula VII and Formula VIII and hydrates, salts, or derivatives thereof.", "The antibiotic/antimicrobial agent may be administered before the one or more compounds in accordance with the present invention, however, in a particularly preferred embodiment the antibiotic/antimicrobial agent is administered simultaneously (such as formulated in the same composition, or administered simultaneously in separate compositions) or after the administration of the compounds of the present invention as described further below in Section III.A of this application, including but not limited to compounds represented by Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, and Formula IX, Formula X, Formula XI, Formula XII, Formula XIII and Formula XIV.", "The antibiotic/antimicrobial agent and/or the one or more compounds of the invention may also be incorporated into a medical device for delivery.", "Also provided are methods for inhibiting biofilm buildup on a surface or for reducing or removing biofilm from a surface.", "The method includes contacting the surface with an effective amount of one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, compounds that bind to major outer membrane proteins (MOMPs) or FlaA of Campylobacter , a mimetic or synthetic human histo-blood group antigen or a synthetic sugar, to inhibit or reduce biofilm buildup or to reduce or remove biofilm from the surface.", "In a preferred embodiment, the method includes administering to the subject an effective amount of one or more compound selected from Fe-QA, Fe-Tyr, Fe-DOPA, and Fe-Phe, and hydrates, salts, or derivatives thereof, to interfere with bacteria binding to the surface or each other.", "The surface to be treated may be contacted with the compounds by coating the surface with the one or more compounds.", "In some embodiments, the surface is contacted by immersing the article to be treated in a composition comprising the one or more compounds of the present invention, or flushing, spraying, irrigating, or wiping the surface with a carrier containing the one or more compounds of the present invention.", "The disclosed methods and uses are useful for inhibiting biofilm build up (or reducing or removing biofilm) produced by microbial species including S. epidermidis, E. faecalis, E. coli, S. aureus, Campylobacter spp.", "H. pylori and Pseudomonas , alone, or in combination, on/in a subject.", "The methods are thus also useful in treating disease conditions caused by these and other microorganisms that are associated with biofilm buildup.", "With respect to surfaces, the disclosed methods and uses employing one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, and more preferably one or more compound selected from Fe-QA, Fe-Tyr, Fe-DOPA, and Fe-Phe, and hydrates, salts, or derivatives thereof, are useful for inhibiting biofilm formation, dispersing biofilms and disinfecting articles, including but not limited to dental instruments, teeth, dentures, dental retainers, dental braces including plastic braces (such as Invisalign), medical instruments, medical devices, contact lenses and lens cases, catheters, surfaces (e.g., tabletop, countertop, bathtub, tile, filters, membranes, etc.", "), tubing, drains, pipes including gas pipes, oil pipes, drilling pipes, fracking pipes, sewage pipes, drainage pipes, hoses, fish tanks, showers, children's toys, boat hulls, and cooling towers.", "A further embodiment of the present invention provides articles treated in accordance with the foregoing methods and uses.", "In further embodiments of the present invention, one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, and more preferably one or more compound selected from Fe-QA, Fe-Tyr, Fe-DOPA, and Fe-Phe, and hydrates, salts, or derivatives thereof, may be used in methods to make antifouling coatings, liquid, spray and towelette dispersants, and wound irrigation solutions.", "In further embodiments of the present invention, one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, and more preferably one or more compound selected from Fe-QA, Fe-Tyr, Fe-DOPA, and Fe-Phe, and hydrates, salts, or derivatives thereof, may also be used in cosmetic formulations, including skin treatments, acne treatments, toothpaste, and mouth rinse formulations.", "The compounds disclosed herein may also be applied to the bristles of toothbrushes, dental flosses, and the like, for oral healthcare.", "Also disclosed are compositions comprising one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, and more preferably one or more compound selected from Fe-QA, Fe-Tyr, Fe-DOPA, and Fe-Phe, and hydrates, salts, or derivatives thereof, and methods using such compositions, for improving growth performance of animal such as livestock (including poultry, cattle, sheep, swine and goats) and other animals as discussed further below in section ILA, and as feed and formula supplements for such animals, in place of, or in combination with, existing bacteriostatic or bactericidal or growth enhancing compounds.", "In a preferred embodiment the compositions may be administered to animals, such as livestock, to increase growth performance.", "The compositions may also be used to decrease mortality adjusted feed conversion ratios (MFCR).", "In a preferred embodiment, the method includes administering to the subject an effective amount of a compound represented by Formula IX, Formula VII and Formula VIII, or a hydrate, salt, or derivative thereof.", "In a particularly preferred embodiment the compositions may be administered to chicken and other animals to promote growth.", "Further related disclosure is provided in section II.A of this application, below." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a division of U.S. Ser.", "No.", "14/823,340 filed Aug. 11, 2015, which claims the benefit of and priority to U.S. Ser.", "No.", "62/188,183 filed Jul.", "2, 2015, U.S. Ser.", "No.", "62/171,081, filed Jun.", "4, 2015, U.S. Ser.", "No.", "62/138,499, filed Mar.", "26, 2015, U.S. Ser.", "No.", "62/137,630, filed Mar.", "24, 2015 and U.S. Ser.", "No.", "62/036,790, filed Aug. 13, 2014, all of which are incorporated by reference in their entirety.", "FIELD OF THE INVENTION The present inventors have identified a class of compounds that has a broad range of antimicrobial and other activities, particularly against bacteria, and has developed numerous uses for, and methods involving, the compounds.", "In one aspect, the invention is generally directed to compositions, methods and uses for inhibiting, reducing, or preventing biofilm formation or buildup on a surface or to removing, dispersing, reducing, or eradicating biofilm on a surface.", "In another embodiment, the invention is also generally relates to compositions, methods and uses for the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments.", "In a further embodiment, the invention also relates to compositions, methods and uses for disinfecting surfaces, both in biological and non-biological environments, and products that have been coated with, or treated by, the compounds or compositions of the present invention.", "In another embodiment, the invention also relates to compositions, methods and uses for potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, including antibiotic-resistant bacteria, to antibiotics and/or other anti-microbial agents, and also to reversing antibiotic resistance in bacteria.", "In yet another embodiment, the invention also relates to compositions, methods and uses for enhancing the growth of animals and their efficiency of feed utilization, in particular by oral administration of feed and/or drink compositions.", "BACKGROUND OF THE INVENTION A biofilm is an accumulation of microorganisms (bacteria, fungi, and/or protozoa, with associated bacteriophages and other viruses) embedded in a polysaccharide matrix and adherent to solid biological or non-biotic surfaces.", "Biofilms are medically important, accounting for over 80 percent of hospital-acquired microbial infections in the body.", "Examples include infections of the: oral soft tissues, teeth and dental implants; middle ear; gastrointestinal tract; urogenital tract; airway/lung tissue; eye; urinary tract prostheses; peritoneal membrane and peritoneal dialysis catheters, indwelling catheters for hemodialysis and for chronic administration of chemotherapeutic agents (Hickman catheters); cardiac implants such as pacemakers, prosthetic heart valves, ventricular assist devices, and synthetic vascular grafts and stents; prostheses, internal fixation devices, percutaneous sutures; and tracheal and ventilator tubing.", "The microorganisms tend to be far more resistant to antimicrobial agents and to be particularly difficult for the host immune system to render an appropriate response.", "Several bacterial pathogens have been shown to associate with, and in some cases, grow in biofilms, including Legionella pneumophila, S. aureus, Listeria monocytogenes, Campylobacter spp., E. coli O157:H7, Salmonella typhimurium, Pseudomonas, Vibrio cholerae, S. epidermidis, E. faecalis, and Helicobacter pylori.", "Biofilms are remarkably difficult to treat with antimicrobials.", "Antimicrobials may be readily inactivated or fail to penetrate into the biofilm.", "In addition, bacteria within biofilms have increased (up to 1,000-fold higher) resistance to antimicrobial compounds, even though these same bacteria are sensitive to these agents if grown under planktonic conditions.", "In addition, bacteria embedded within biofilms are resistant to both immunological and non-specific defense mechanisms of the body.", "Contact with a solid surface triggers the expression of a panel of bacterial enzymes, which catalyze the formation of sticky polysaccharides that promote colonization and protection.", "The structure of biofilms is such that immune responses may be directed only at those antigens found on the outer surface of the biofilm, and antibodies and other serum or salivary proteins often fail to penetrate into the biofilm.", "In addition, phagocytes are unable to effectively engulf a bacterium growing within a complex polysaccharide matrix attached to a solid surface.", "This causes the phagocyte to release large amounts of pro-inflammatory enzymes and cytokines, leading to inflammation and destruction of nearby tissues.", "Conventional therapy is characteristically ineffective against biofilms, as the minimum inhibitory concentration (MIC) of antimicrobial agents has been shown to be 10 to 1000 fold greater than for planktonic organisms (Hoiby, et al., Int J Antimicrob Agents, 35(4):322-32 (2010).", "It is an object of the present invention to provide compositions and methods for inhibiting or preventing biofilm formation or promoting biofilm dissolution from surfaces of interest.", "It is still an object of the present invention to provide methods for reducing the transmission of pathogens in biofilm.", "It is a further object of the present invention to provide methods to treat antibiotic resistant bacteria.", "It is yet a further object to provide compositions to improve growth performance.", "SUMMARY OF THE INVENTION The present inventors have identified a class of compounds, as described further below in Section III.A of this application, that have surprisingly been found to provide a broad range of activity, particularly against a diverse array of bacteria.", "The present invention provides numerous uses for, and methods involving, the compounds, particularly in the formation of compositions.", "The present invention also provides compositions, articles and products comprising one or more of the compounds, as described further below.", "The present invention also provides products produced by the application of the numerous uses and methods of the present invention, as well as downstream products produced therefrom.", "In one embodiment, the present invention provides compounds as described further below in Section III.A of this application and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for inhibiting, reducing, or preventing biofilm formation or buildup on a surface or to removing, dispersing, reducing, or eradicating biofilm on a surface.", "Accordingly, compositions for inhibiting, reducing, or removing biofilm buildup in a subject and/or on an article or other item are provided.", "An exemplary compounds and composition include an effective amount of one or more compound selected from Ferric Quinate (Fe-QA, also referred to herein as FeQ), and ferric complexes with L-tyrosine (Fe-Tyr), L-DOPA (Fe-DOPA), L-phenylalanine (Fe-Phe) and hydrates, salts, or derivatives thereof.", "See Formulas IX, VIII and VII, as defined further below, respectively.", "The compositions are effective against biofilms produced by a wide range of microbial species including, without limitation, S. epidermidis, E. faecalis, E. coli, S. aureus, Campylobacter spp.", "H. pylori and Pseudomonas, alone, or in combination.", "In an embodiment, an article or product, including medical devices having on the surface or dispersed therein one or more of the compounds as described further below in Section III.A of this application, or composition comprising the one or more compounds, for example of Formula IX (Fe-QA, or also referred to as FeQ), Formula VII (Fe-DOPA also referred to as FeDOPA) and Formula VIII (Fe-Tyr), or Fe-Phe, are prepared to prevent or reduce the formation of a biofilm on the article, or product, such as to prevent or reduce the formation of a biofilm on the medical device after implantation.", "The surface may be a biological surface (such as a surface of a living human, animal or plant surface, or the surface of a dead or harvested animal or plant), or a non-biological surface including for example, plastics, polymers, biomaterials, and metals.", "The present invention also provides products treated according to this embodiment.", "In another embodiment, the invention provides compounds as described further below in Section III.A of this application and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments.", "In a further embodiment, the invention also relates to compounds and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for disinfecting surfaces, both in biological and non-biological environments, and products that have been coated with, or treated by, one or more of the compounds and/or compositions of the present invention.", "In another embodiment, the invention also relates to compounds and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for potentiating the effects of one or more antibiotics, increasing the sensitivity of bacteria (including antibiotic-resistant bacteria) to one or more antibiotics, and also to reversing antibiotic resistance in bacteria.", "In yet another embodiment, the invention also relates to compounds and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for enhancing the growth of animals and their efficiency of feed utilization, in particular by oral administration of feed and drink compositions.", "Also provided are methods of treating microbial infections in a subject by inhibiting, reducing, or removing biofilm buildup in the subject and methods for treating subjects with microbial infections that are resistant to antibiotics.", "One method includes administering to the subject an effective amount of one or more compounds as described further below in Section III.A of this application, including but not limited to compounds according to Formula A or B as described therein, one or more compounds that bind to major outer membrane proteins (MOMPs) or FlaA of Campylobacter, a mimetic or synthetic human histo-blood group antigen or a synthetic sugar.", "In one embodiment, the method includes administering to the subject an effective amount of a compound represented by Formula I, Formula II, Formula III, Formula IV, Formula V, and Formula VI.", "In a preferred embodiment, the method includes administering to the subject an effective amount of a compound represented by Formula IX (ferric quinate, Fe-QA also designated as FeQ), Formula VII (Fe-DOPA), Formula VIII (Fe-Tyr), or Fe-Phe, and hydrates, salts, or derivatives thereof.", "In another preferred embodiment, the one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as descried therein, one or more compounds of Formula I-IX orX-XIV, or compositions comprising one or more of said compounds, may be used to cure, treat, or prevent symptoms of or associated with a variety of conditions as described herein, such as arterial damage, gastritis, urinary tract infections, biliary tract infections, pyelonephritis, cystitis, sinus infections, ear infections, otitis media, otitis externa, leprosy, tuberculosis, conjunctivitis, bloodstream infections, benign prostatic hyperplasia, chronic prostatitis, lung infections including chronic lung infections of humans with cystic fibrosis, osteomyelitis, catheter infections, bloodstream infections, skin infections, acne, rosacea, dental caries, periodontitis, gingivitis, nosocomial infections, arterial damage, endocarditis, periprosthetic joint infections, open or chronic wound infections, venous stasis ulcers, diabetic ulcers, arterial leg ulcers, pressure ulcers, endocarditis, pneumonia, orthopedic prosthesis and orthopedic implant infections, peritoneal dialysis peritonitis, cirrhosis, and any other acute or chronic infection that involves or is associated with a biofilm.", "In a preferred embodiment for treating antibiotic- (or other antimicrobial-) resistant microbial infections, the method includes administering to the subject an effective amount of an antibiotic or other antimicrobial agent (which may be the antibiotic/antimicrobial to which the microbial infection is resistant) and an effective amount of one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, or one or more compounds represented by any of Formulae I to XIV, such as Formula I, Formula II, Formula III, Formula IV, Formula V, and Formula VI or, preferably, an effective amount of one or more compound represented by Formula IX, Formula VII and Formula VIII and hydrates, salts, or derivatives thereof.", "The antibiotic/antimicrobial agent may be administered before the one or more compounds in accordance with the present invention, however, in a particularly preferred embodiment the antibiotic/antimicrobial agent is administered simultaneously (such as formulated in the same composition, or administered simultaneously in separate compositions) or after the administration of the compounds of the present invention as described further below in Section III.A of this application, including but not limited to compounds represented by Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, and Formula IX, Formula X, Formula XI, Formula XII, Formula XIII and Formula XIV.", "The antibiotic/antimicrobial agent and/or the one or more compounds of the invention may also be incorporated into a medical device for delivery.", "Also provided are methods for inhibiting biofilm buildup on a surface or for reducing or removing biofilm from a surface.", "The method includes contacting the surface with an effective amount of one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, compounds that bind to major outer membrane proteins (MOMPs) or FlaA of Campylobacter, a mimetic or synthetic human histo-blood group antigen or a synthetic sugar, to inhibit or reduce biofilm buildup or to reduce or remove biofilm from the surface.", "In a preferred embodiment, the method includes administering to the subject an effective amount of one or more compound selected from Fe-QA, Fe-Tyr, Fe-DOPA, and Fe-Phe, and hydrates, salts, or derivatives thereof, to interfere with bacteria binding to the surface or each other.", "The surface to be treated may be contacted with the compounds by coating the surface with the one or more compounds.", "In some embodiments, the surface is contacted by immersing the article to be treated in a composition comprising the one or more compounds of the present invention, or flushing, spraying, irrigating, or wiping the surface with a carrier containing the one or more compounds of the present invention.", "The disclosed methods and uses are useful for inhibiting biofilm build up (or reducing or removing biofilm) produced by microbial species including S. epidermidis, E. faecalis, E. coli, S. aureus, Campylobacter spp.", "H. pylori and Pseudomonas, alone, or in combination, on/in a subject.", "The methods are thus also useful in treating disease conditions caused by these and other microorganisms that are associated with biofilm buildup.", "With respect to surfaces, the disclosed methods and uses employing one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, and more preferably one or more compound selected from Fe-QA, Fe-Tyr, Fe-DOPA, and Fe-Phe, and hydrates, salts, or derivatives thereof, are useful for inhibiting biofilm formation, dispersing biofilms and disinfecting articles, including but not limited to dental instruments, teeth, dentures, dental retainers, dental braces including plastic braces (such as Invisalign), medical instruments, medical devices, contact lenses and lens cases, catheters, surfaces (e.g., tabletop, countertop, bathtub, tile, filters, membranes, etc.", "), tubing, drains, pipes including gas pipes, oil pipes, drilling pipes, fracking pipes, sewage pipes, drainage pipes, hoses, fish tanks, showers, children's toys, boat hulls, and cooling towers.", "A further embodiment of the present invention provides articles treated in accordance with the foregoing methods and uses.", "In further embodiments of the present invention, one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, and more preferably one or more compound selected from Fe-QA, Fe-Tyr, Fe-DOPA, and Fe-Phe, and hydrates, salts, or derivatives thereof, may be used in methods to make antifouling coatings, liquid, spray and towelette dispersants, and wound irrigation solutions.", "In further embodiments of the present invention, one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, and more preferably one or more compound selected from Fe-QA, Fe-Tyr, Fe-DOPA, and Fe-Phe, and hydrates, salts, or derivatives thereof, may also be used in cosmetic formulations, including skin treatments, acne treatments, toothpaste, and mouth rinse formulations.", "The compounds disclosed herein may also be applied to the bristles of toothbrushes, dental flosses, and the like, for oral healthcare.", "Also disclosed are compositions comprising one or more compounds as described further below in Section III.A of this application, including but not limited to one or more compounds according to Formula A or B as described therein, and more preferably one or more compound selected from Fe-QA, Fe-Tyr, Fe-DOPA, and Fe-Phe, and hydrates, salts, or derivatives thereof, and methods using such compositions, for improving growth performance of animal such as livestock (including poultry, cattle, sheep, swine and goats) and other animals as discussed further below in section ILA, and as feed and formula supplements for such animals, in place of, or in combination with, existing bacteriostatic or bactericidal or growth enhancing compounds.", "In a preferred embodiment the compositions may be administered to animals, such as livestock, to increase growth performance.", "The compositions may also be used to decrease mortality adjusted feed conversion ratios (MFCR).", "In a preferred embodiment, the method includes administering to the subject an effective amount of a compound represented by Formula IX, Formula VII and Formula VIII, or a hydrate, salt, or derivative thereof.", "In a particularly preferred embodiment the compositions may be administered to chicken and other animals to promote growth.", "Further related disclosure is provided in section II.A of this application, below.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1A is a bar graph showing biofilm formation by Enterococcus faecalis at time T=0 in the presence of absence of different concentrations of Fe-QA.", "FIG.", "1B is a bar graph showing biofilm formation by Enterococcus faecalis at time T=24 h in the presence or absence of different concentrations of Fe-QA.", "FIG.", "2A is a bar graph showing biofilm formation by Staphylococcus epidermidis at time T=0 in the presence of absence of different concentrations of Fe-QA.", "FIG.", "2B is a bar graph showing biofilm formation by Staphylococcus epidermidis at time T=24 h in the presence of absence of different concentrations of Fe-QA.", "FIG.", "3A is a bar graph showing biofilm formation by Staphylococcus aureus at time T=0 in the presence of absence of different concentrations of Fe-QA.", "FIG.", "3B is a bar graph showing biofilm formation by Staphylococcus aureus at time T=24 h in the presence of absence of different concentrations of Fe-QA.", "FIG.", "4A is a bar chart showing the binding of C. jejuni to the BgAgs (common ABO histo-blood group antigens), Leb and H-II, after growing the bacteria in a medium that has either Fe-QA at a concentration of 0.34 mM or 3.4 mM.", "Binding is shown after one passage and four passages (4 generations) with Fe-QA included in the medium, and compared to a control without Fe-QA.", "FIG.", "4B is a bar graph showing the binding of C. jejuni 11168 to BgAgs (common ABO histo-blood group antigens, Core-I, Core-II, H-I, H-II, Leb, Ley and Lex), and the inhibition of this binding by the Fe-QA (inhibitor).", "FIG.", "5A is a bar graph showing the effect of Fe-QA treatment on Helicobacter pylori attachment to human gastric tissue.", "FIG.", "5B is a line graph showing the competitive inhibition of Leb binding to H. pylori by Fe-QA as the concentration of Fe-QA is increased.", "The graph is a plot of the ratio of bound to free Leb versus Fe-QA concentration.", "FIG.", "6A is a bar graph showing the coverage rate of PAO1 Pseudomonas aeruginosa on the surface of a glass slide, comparing Pseudomonas medium only as a control, PAO1 Pseudomonas+100 μM Fe-QA treatment, and PAO1 Pseudomonas with no Fe-QA (X=Fe-QA).", "The graph shows that 100 μM Fe-QA (“X”) inhibits the formation of biofilm by P. aeruginosa.", "FIG.", "6B is a bar graph showing that Fe-QA inhibits formation of biofilm by Uropathogenic E. coli (UPEC).", "The bar graph shows the coverage rate of UPEC on the surface of a glass slide compared to a UPEC medium only control, and UPEC growing in the presence of 0.1 μM, 1 μM, 10 μM, and 100 μM concentrations of Fe-QA.", "FIG.", "7A is a graph showing the growth rate of UPEC in the presence of 100 μM Fe-QA and without Fe-QA over a period of 24 hours.", "RPMI-1640 (bottom line); RPMI-1640+UPEC (middle line); RPMI-1640+100 μM FeQ+UPEC (top line).", "FIG.", "7B is a graph showing the growth rate of Pseudomonas aeruginosa in the presence of 100 μM Fe-QA and without Fe-QA.", "RPMI-1640 (bottom line); RPMI-1640+UPEC (middle line); RPMI 1640+100 μM FeQ+PAO1 (top line).", "FIG.", "8A is a bar chart showing the planktonic growth rates of wildtype Campylobacter jejuni and the same strain after mutation of the T268 of MOMP.", "T268 of MOMP is replaced by glycine to form the MOMP-T strain.", "FIG.", "8B is a bar chart showing the abilities of the wildtype Campylobacter jejuni and the MOMP-T mutant to form biofilms.", "FIG.", "9 is a graph showing the impact of Fe-QA on the rate of growth of a kanamycin resistant strain of E. coli.", "The groups, numbered from the top are as follows: (1) AsdiA-FEQ; (2) AsdiA-FEQ+Kan; (3) AsdiA-FEQ-Kan; (4) medium FEQ; (5) medium-FEQ+Kan; (6) medium-Kan.", "The graph shows the rate of growth of the strain in the presence of Fe-QA ((1)—upper line), kanamycin ((2)—triangles) and a combination of Fe-QA and kanamycin ((3), squares).", "Three baselines are shown for just the medium containing Fe-QA, Fe-QA and kanamycin, and kanamycin alone.", "FIG.", "10A shows the impact on the growth curve of antibiotic resistant Enteropathogenic E. coli (EPEC) strain E2348/69 (genotype Wild Type EPEC O17:H6) when grown in the presence of (i) gentamicin (1.25 μM) (grey circles), (ii) Fe-Tyr (100 μM) (inverted grey triangle ), (iii) gentamicin (1.25 μM) and Fe-Tyr (1.25 μM) (upright white triangle, Δ), and (iv) a control with no gentamicin or Fe-Tyr present (black circles).", "FIG.", "10B shows the Δ growth rate of Enteropathogenic E. coli (EPEC) strain E2348/69 when grown in the presence of (i) gentamicin (1.25 μM), (ii) Fe-Tyr (100 μM), (iii) gentamicin (1.25 μM) and Fe-Tyr (1.25 μM), and (iv) a control with no gentamicin or Fe-Tyr present.", "FIGS.", "11A-C show the impact on the growth curve of antibiotic resistant Enteropathogenic E. coli (EPEC) strain E2348/69 (genotype Wild Type EPEC O17:H6) when grown in the presence of gentamicin (1.25 μM) and increasing concentrations (10-68 μM) of Fe-QA (also known as FeQ).", "FIG.", "11D compares the growth rates of Enteropathogenic E. coli (EPEC) strain E2348/69 when grown in the presence of 10, 34, 68 and 100 μM Fe-QA.", "FIG.", "11E compares the growth rates of Enteropathogenic E. coli (EPEC) strain E2348/69 when grown in the presence of a fixed concentration of gentamicin (1.25 μM) and increasing concentrations of Fe-QA ranging from 10 to 100 μM.", "FIG.", "12 shows quantitatively the difference in the attachment of EPEC cells to the plastic well surface in the absence and presence of FeQ by measurement of the optical absorbance of crystal violet that was absorbed by EPEC cells attached to the surface.", "FIG.", "13 is a graph showing the impact of growth rates of an antibiotic-resistant clinical isolate of Pseudomonas in the presence of kanamycin, FeQ, and kanamycin plus FeQ compared to the strain grown in the absence of kanamycin and FeQ.", "FIGS.", "14A-C show chemical structures of how FeQ can be conjugated to an agent that contains a reactive functional group suitable for immobilizing FeQ, for example, on a surface.", "FIG.", "14A shows the conjugation of FeQ to a calix[4] arene frame that contains a photoreactive functional group.", "FIG.", "14B shows the conjugation of FeQ to a calix [4] arene frame wherein the photo-reactive functional group is positioned in a different location on the calix [4] arene frame compared to the structure of FIG.", "14B.", "FIG.", "14C shows the conjugation of FeQ to a calix[4] arene frame functionalized with two thiol groups.", "FIGS.", "15A and B are chemical structures that illustrate how FeQ can be conjugated via a linker to a substance that binds to a surface.", "In both structures, the linker is spaced between functional groups Y′ and X′, attached to FeQ via Y′ and to hydroxyapatite (HA) via X′.", "The figures differ in the point of attachment to the quinic acid ligand.", "FIG.", "16 is a graph showing that the wildtype O-glycosylated strain of Campylobacter dominates infection of chicken colonized by a mixed population of O-glycosylated and non-glycosylated (MOMPT268G) Campylobacter, and that the non-glycosylated bacteria is unable to colonize in a mixed population.", "FIG.", "17 is a graph showing the average body weight (ABW) of chicken after 42 days of growth.", "The graph compares the ABW at 42 days of chicken challenged with Campylobacter-infected dirty litter at day 20 and treated from days 0-42 with FeQ or FeTyr to (i) a standard commercial target (of 2.979 kg) labeled “Target”, (ii) a negative control (of 3.437 kg) labeled “CNC” where the chicken were not challenged with Campylobacter-infected dirty litter, and (iii) a positive control (of 3.186 kg) labeled “CC” where the chicken were challenged with Campylobacter-infected dirty litter.", "The graph shows that birds challenged with Campylobacter-infected dirty litter have higher ABW at 42 days compared to the positive control (labeled “CC”) when treated with (iv) FeQ at 0.22 g/L in drinking water and FeQ at 0.22 g/kg in feed, labeled “FeQ(W+F)” with an ABW of 3.342 kg, (v) FeQ at 0.22 g/L in drinking water, labeled “FeQ(W)” with an ABW of 3.407 kg, (vi) FeQ at 0.22 g/kg in feed, labeled “FeQ(F)” with an ABW of 3.464 kg, (vii) FeQ at 0.022 g/L in drinking water, labeled “FeQ(W)” with an ABW of 3.304 kg, and (viii) FeTyr at 0.02 g/L in drinking water, labeled FeTyr(W) with an ABW of 3.341 kg.", "FIG.", "18 is a graph showing the mortality adjusted feed conversion ratio (MFCR) of chicken after 42 days of growth.", "The graph compares the MFCR at 42 days of chicken challenged with Campylobacter-infected dirty litter at day 20 and treated from days 0-42 with FeQ or FeTyr to (i) a standard commercial target (of 1.703) labeled “Target”, (ii) a negative control (of 1.563) labeled “CNC” where the chicken were not challenged with Campylobacter, and (iii) a positive control (of 1.679) labeled “CC” where the chicken were challenged with Campylobacter-infected dirty litter.", "The graph shows that birds challenged with Campylobacter-infected dirty litter have lower MFCR at 42 days compared to the positive control (labeled “CC”) when treated with (iv) FeQ at 0.22 g/L in drinking water and FeQ at 0.22 g/kg in feed, labeled “FeQ(W+F)” with a MFCR of 1.595, (v) FeQ at 0.22 g/L in drinking water, labeled “FeQ(W)” with a MFCR of 1.560, (vi) FeQ at 0.22 g/kg in feed, labeled “FeQ(F)” with a MFCR of 1.563, (vii) FeQ at 0.022 g/L in drinking water, labeled “FeQ(W)” with a MFCR of 1.612, and (viii) FeTyr at 0.02 g/L in drinking water, labeled FeTyr(W) with a MFCR of 1.577.FIG.", "19 is a graph showing the number of Campylobacter colony forming units per gram (cfu/g) of bird droppings at day 42.The graph compares the cfu/g at day 42 of chicken that were challenged with Campylobacter-infected dirty litter at day 20 and treated from days 0-42 with FeQ or FeTyr to (i) a negative control labeled “CNC” (with a cfu/g of 28,000) where the chicken were not challenged with Campylobacter-infected dirty litter, and (ii) a positive control labeled “CC” (with a cfu/g of 1,280,000) where chickens were challenged with Campylobacter-infected dirty litter at day 21.The graph shows that birds treated with FeQ or FeTyr have lower levels of Campylobacter in their droppings at day 42 when treated with (iii) FeQ at 0.22 g/L in drinking water and FeQ at 0.22 g/kg in feed, labeled “FeQ(W+F)” with a cfu/g of 4,860, (iv) FeQ at 0.22 g/kg in feed, labeled “FeQ(F)” with a cfu/g of 12,800, (v) FeQ at 0.022 g/L in drinking water, labeled “FeQ(W)” with a cfu/g of 900,000, and (vi) FeTyr at 0.02 g/L in drinking water, labeled FeTyr(W) with a cfu/g of 16,600.FIG.", "20 is a graph showing the average number of Campylobacter colony forming units per gram (cfu/g) of caeca samples at day 42.The graph compares the cfu/g at day 42 of chicken that were challenged with Campylobacter-infected dirty litter at day 20 and treated from days 0-42 with FeQ or FeTyr to (i) a negative control labeled “Treatment-1” where the chicken were not challenged with Campylobacter-infected dirty litter, and (ii) a positive control labeled “Treatment-2” where chickens were challenged with Campylobacter-infected dirty litter at day 21.The graph shows that birds treated with FeQ or FeTyr have lower levels of Campylobacter in their caeca at day 42 when treated with (iii) FeQ at 0.22 g/L in drinking water and FeQ at 0.22 g/kg in feed, labeled “Treatment-3”, (iv) FeQ at 0.22 g/L in water, labeled “Treatment-5”, (v) FeQ at 0.22 g/kg in feed, labeled “Treatment-6”, (vi) FeQ at 0.022 g/L in drinking water, labeled “Treatment-7”, and (vii) FeTyr at 0.02 g/L in drinking water, labeled “Treatment-8”.", "FIGS.", "21A-C show the impact on the growth curve of antibiotic resistant Enteropathogenic E. coli (EPEC) strain E2348169 (genotype Wild Type EPEC O17:H6) when grown in the presence of gentamicin (1.25 μM) and increasing concentrations (130-200 μM) of Fe-DOPA.", "FIG.", "22 is shows quantitatively the difference in the attachment of EPEC cells to the plastic well surface in the absence and presence of FeDOPA (also referred to as Fe-DOPA) by measurement of the optical absorbance of crystal violet that was absorbed by EPEC cells attached to the surface.", "FIG.", "23 shows 3 bar graphs at 24, 48 and 72 hours of the optical absorbance of crystal violet that was absorbed by the EPEC cells that remained attached to the surface of the plastic well after a mature biofilm formed by EPEC-pgA++ was treated with FeTyr (shown as “FeY” in FIG.", "23) at 100 μM, 150 μM and 200 μM compared to an untreated biofilm (labeled “Control”) in a crystal violet assay.", "FIG.", "24A shows the data from positive mode analysis, as an OPLS-DA scores plot.", "This shows a clear separation between fresh media (FM) and other spent media (SMWT; SMWTF; SMMT; SMMTF).", "FIG.", "24B also shows the data from the positive mode analysis, in which the fresh media (FM) results were removed from the plot.", "FIG.", "24C contrasts from FIG.", "24A in that it shows the data from the negative mode analysis.", "FIG.", "24D contrasts with FIG.", "24B in that it shows the data from the negative mode analysis.", "FIGS.", "25A and B show the results of Example 30, which investigate effects upon antibiotic resistance of a laboratory strain of Psuedomonas aeruginosa (PAO1N) and a mixed population of clinical isolates (PAO Mixed), when incubated in Luria-Bertani (LB) media alone, or with different concentrations (34 μM, 100 μM, 200 μM and 340 μM) of FeQ or FePhe.", "FIG.", "25A shows the results with PAO1N cultures.", "FIG.", "25B shows the results with PAO Mixed cultures.", "DETAILED DESCRIPTION OF THE INVENTION I. Definitions “Aerosol” as used herein refers to any preparation of a fine mist of particles, which can be in solution or a suspension, whether or not it is produced using a propellant.", "The term “alkyl” refers to the radical of saturated aliphatic groups (i.e., an alkane with one hydrogen atom removed), including straight-chain alkyl groups, branched-chain alkyl groups, cycloalkyl (alicyclic) groups, alkyl-substituted cycloalkyl groups, and cycloalkyl-substituted alkyl groups.", "In preferred embodiments, a straight chain or branched chain alkyl has 30 or fewer carbon atoms in its backbone (e.g., C1-C30 for straight chains, and C3-C30 for branched chains), preferably 20 or fewer, more preferably 15 or fewer, most preferably 10 or fewer.", "Likewise, preferred cycloalkyls have 3-10 carbon atoms in their ring structure, and more preferably have 5, 6, or 7 carbons in the ring structure.", "The term “alkyl” (or “lower alkyl”) as used throughout the specification, examples, and claims is intended to include both “unsubstituted alkyls” and “substituted alkyls”, the latter of which refers to alkyl moieties having one or more substituents replacing a hydrogen on one or more carbons of the hydrocarbon backbone.", "Such substituents include, but are not limited to, halogen, hydroxyl, carbonyl (such as a carboxyl, alkoxycarbonyl, formyl, or an acyl), thiocarbonyl (such as a thioester, a thioacetate, or a thioformate), alkoxyl, phosphoryl, phosphate, phosphonate, phosphinate, amino, amido, amidine, imine, cyano, nitro, azido, sulfhydryl, alkylthio, sulfate, sulfonate, sulfamoyl, sulfonamido, sulfonyl, heterocyclyl, aralkyl, or an aromatic or heteroaromatic moiety.", "Unless the number of carbons is otherwise specified, “lower alkyl” as used herein means an alkyl group, as defined above, but having from one to ten carbons, more preferably from one to six carbon atoms in its backbone structure.", "Likewise, “lower alkenyl” and “lower alkynyl” have similar chain lengths.", "Throughout the application, preferred alkyl groups are lower alkyls.", "In preferred embodiments, a substituent designated herein as alkyl is a lower alkyl.", "It will be understood by those skilled in the art that the moieties substituted on the hydrocarbon chain can themselves be substituted, if appropriate.", "For instance, the substituents of a substituted alkyl may include halogen, hydroxy, nitro, thiols, amino, azido, imino, amido, phosphoryl (including phosphonate and phosphinate), sulfonyl (including sulfate, sulfonamido, sulfamoyl and sulfonate), and silyl groups, as well as ethers, alkylthios, carbonyls (including ketones, aldehydes, carboxylates, and esters), —CF3, —CN and the like.", "Cycloalkyls can be substituted in the same manner.", "The term “heteroalkyl”, as used herein, refers to straight or branched chain, or cyclic carbon-containing radicals, or combinations thereof, containing at least one heteroatom.", "Suitable heteroatoms include, but are not limited to, O, N, Si, P, Se, B, and S, wherein the phosphorous and sulfur atoms are optionally oxidized, and the nitrogen heteroatom is optionally quaternized.", "Heteroalkyls can be substituted as defined above for alkyl groups.", "The terms “alkenyl” and “alkynyl”, refer to unsaturated aliphatic groups analogous in length and possible substitution to the alkyls described above, but that contain at least one double or triple bond respectively.", "The terms “alkoxyl” or “alkoxy” as used herein refers to an alkyl group, as defined above, having an oxygen radical attached thereto.", "Representative alkoxyl groups include methoxy, ethoxy, propyloxy, tert-butoxy and the like.", "An “ether” is two hydrocarbons covalently linked by an oxygen.", "Accordingly, the substituent of an alkyl that renders that alkyl an ether is or resembles an alkoxyl, such as can be represented by one of —O— alkyl, —O-alkenyl, and —O-alkynyl.", "The terms “aroxy” and “aryloxy”, as used interchangeably herein, can be represented by —O-aryl or O-heteroaryl, wherein aryl and heteroaryl are as defined below.", "The alkoxy and aroxy groups can be substituted as described above for alkyl.", "“Aryl”, as used herein, refers to C5-C10-membered aromatic, heterocyclic, fused aromatic, fused heterocyclic, biaromatic, or bihetereocyclic ring systems.", "Broadly defined, “aryl”, as used herein, includes 5-, 6-, 7-, 8-, 9-, and 10-membered single-ring aromatic groups that may include from zero to four heteroatoms, for example, benzene, pyrrole, furan, thiophene, imidazole, oxazole, thiazole, triazole, pyrazole, pyridine, pyrazine, pyridazine, pyrimidine, and the like.", "Those aryl groups having heteroatoms in the ring structure may also be referred to as “aryl heterocycles” or “heteroaromatics”.", "The aromatic ring can be substituted at one or more ring positions with one or more substituents including, but not limited to, halogen, azide, alkyl, aralkyl, alkenyl, alkynyl, cycloalkyl, hydroxyl, alkoxyl, amino (or quaternized amino), nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, carbonyl, carboxyl, silyl, ether, alkylthio, sulfonyl, sulfonamido, ketone, aldehyde, ester, heterocyclyl, aromatic or heteroaromatic moieties, —CF3, —CN, and combinations thereof.", "The term “aryl” also includes polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjoining rings (i.e., “fused rings”) wherein at least one of the rings is aromatic, e.g., the other cyclic ring or rings can be cycloalkyls, cycloalkenyls, cycloalkynyls, aryls and/or heterocycles.", "Examples of heterocyclic rings include, but are not limited to, benzimidazolyl, benzofuranyl, benzothiofuranyl, benzothiophenyl, benzoxazolyl, benzoxazolinyl, benzthiazolyl, benztriazolyl, benztetrazolyl, benzisoxazolyl, benzisothiazolyl, benzimidazolinyl, carbazolyl, 4aH carbazolyl, carbolinyl, chromanyl, chromenyl, cinnolinyl, decahydroquinolinyl, 2H,6H-1,5,2-dithiazinyl, dihydrofuro[2,3 b]tetrahydrofuran, furanyl, furazanyl, imidazolidinyl, imidazolinyl, imidazolyl, 1H-indazolyl, indolenyl, indolinyl, indolizinyl, indolyl, 3H-indolyl, isatinoyl, isobenzofuranyl, isochromanyl, isoindazolyl, isoindolinyl, isoindolyl, isoquinolinyl, isothiazolyl, isoxazolyl, methylenedioxyphenyl, morpholinyl, naphthyridinyl, octahydroisoquinolinyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, oxazolidinyl, oxazolyl, oxindolyl, pyrimidinyl, phenanthridinyl, phenanthrolinyl, phenazinyl, phenothiazinyl, phenoxathinyl, phenoxazinyl, phthalazinyl, piperazinyl, piperidinyl, piperidonyl, 4-piperidonyl, piperonyl, pteridinyl, purinyl, pyranyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pyridooxazole, pyridoimidazole, pyridothiazole, pyridinyl, pyridyl, pyrimidinyl, pyrrolidinyl, pyrrolinyl, 2H-pyrrolyl, pyrrolyl, quinazolinyl, quinolinyl, 4H-quinolizinyl, quinoxalinyl, quinuclidinyl, tetrahydrofuranyl, tetrahydroisoquinolinyl, tetrahydroquinolinyl, tetrazolyl, 6H-1,2,5-thiadiazinyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, thianthrenyl, thiazolyl, thienyl, thienothiazolyl, thienooxazolyl, thienoimidazolyl, thiophenyl, and xanthenyl.", "One or more of the rings can be substituted as defined above for “aryl”.", "The term “aralkyl”, as used herein, refers to an alkyl group substituted with an aryl group (e.g., an aromatic or heteroaromatic group).", "The term “aralkyloxy” can be represented by —O-aralkyl, wherein aralkyl is as defined above.", "“Biofilm” as used herein refers any group of microorganisms in which cells stick to each other on a surface.", "A “cream” is a viscous liquid or semi-solid emulsion of either the “oil-in-water” or “water-in-oil type”.", "An “emulsion” is a composition containing a mixture of non-miscible components homogenously blended together.", "“Gel” as used herein is a colloid in which the dispersed phase has combined with the continuous phase to produce a semisolid material, such as jelly.", "“Cleaning formulation”, as used herein, means a composition suitable for application to a surface for removing dirt and oils, for disinfecting, or a combination thereof.", "Cleaning formulations can be antibacterial, antimicrobial, or both.", "Cleaning formulations are suitable for use on the human skin, when none of the components of the composition are present at concentrations that cause significant signs of irritation when applied to human skin.", "As used herein, “significant signs of irritation” include erythema, redness, and/or swelling at the site of injection or at the site of application, necrosis at the site of application, exfoliative dermatitis at the site of application, and severe pain that prevents daily activity and/or requires medical attention or hospitalization.", "Cleaning formulations can be suitable for use in the human buccal cavity.", "Cleaning formulations can be suitable for use with articles that, subsequent to exposure and optionally with residual levels of cleaning composition present on and/or in the article, will then be contacted with the human skin or other part of the human body, such as wherein the article (e.g.", "a denture) will be contacted with the buccal cavity, or will be contacted with the eye (e.g.", "a contact lens).", "Cleaning formulations can be suitable for use with foodstuffs and/or their packaging and may, for example, be suitable for cleaning meat products and/or carcasses used in the production of meat products.", "Cleaning formulations may be suitable for cleaning equipment used in food production.", "Cleaning formulations may be suitable for use in cleaning medical devices, including implantable medical devices.", "Many other types of cleaning formulations may also be provided by the present invention, further examples of which are discussed in further sections of this application.", "“Chronic wound” as used herein refers to a wound that fails to progress through an orderly and timely sequence of repair or a wound that does not respond to treatment and/or the demands of treatment are beyond the patient's physical health, tolerance or stamina.", "Many wounds that are first considered to be acute wounds ultimately become chronic wounds due to factors still not well understood.", "One significant factor is the transition of planktonic bacteria within the wound to form a biofilm.", "The term “heteroatom” as used herein means an atom of any element other than carbon or hydrogen.", "Preferred heteroatoms are boron, nitrogen, oxygen, phosphorus, sulfur, and selenium.", "Other heteroatoms include silicon and arsenic.", "“Inhibition” or “inhibiting” of biofilm formation as used herein refers to a decrease of biofilm associated microorganism formation and/or growth.", "A “lotion” is a low- to medium-viscosity liquid formulation.", "As used herein, the term “nitro” means —NO2; the term “halogen” designates —F, —Cl, —Br, or —I; the term “sulfhydryl” means —SH; the term “hydroxyl” means —OH; and the term “sulfonyl” means —SO2—.", "“Oil” as used herein refers to a composition containing at least 95% wt.", "of a lipophilic substance.", "Examples of lipophilic substances include but are not limited to naturally occurring and synthetic oils, fats, fatty acids, lecithins, triglycerides and combinations thereof.", "An “ointment” is a semisolid preparation containing an ointment base and optionally one or more active agents.", "“Parenteral administration”, as used herein, means administration by any method other than through the digestive tract or non-invasive topical or regional routes.", "“Patient” or “subject” to be treated and/or used in accordance with any of the aspect of the present invention as described herein refers to either a human or non-human animal such as a primate, non-human primate, laboratory animal, farm animal, livestock, or a domestic pet.", "Exemplary animals can optionally include chickens, particularly a meat-type chicken such as broiler chicken, or an egg-laying chicken such as a pullet or hen, or a breeder chicken.", "Also optionally included without limitation are other poultry, such as a turkey, geese, quail or ducks, or livestock, such as cattle, sheep, goats or swine, alpaca, banteng, bison, camel, cat, deer, dog, donkey, gayal, guinea pig, horse, llama, mule, rabbit, reindeer, water buffalo, yak, although the skilled person will appreciate that other animals, including zoo animals, captive animals, game animals, fish (include freshwater and saltwater fish, farmed fish, and ornamental fish), other marine and aquatic animals, including shellfish such as, but not limited to, oysters, mussels, clams, shrimps, prawns, lobsters, crayfish, crabs, cuttlefish, octopus, and squid, domestic animals such as cats and dogs, rodents (such as mice, rats, guinea pigs, hamsters), and horses, are also included, as well as any other domestic, wild and farmed animal, including mammals, marine animals, amphibians, birds, reptiles, insects and other invertebrates.", "“Pharmaceutically acceptable” as used herein refers to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals (such as one or more of the animal “patients” or “subjects” as discussed above) without excessive toxicity, irritation, allergic response, or other problems or complications commensurate with a reasonable benefit/risk ratio.", "“Pharmaceutically acceptable salt”, as used herein, refers to derivatives of the compounds defined herein, wherein the parent compound is modified by making acid or base salts thereof.", "“Therapeutically effective” or “effective amount” as used herein means that the amount of the composition used is of sufficient quantity to ameliorate one or more causes or symptoms of a condition, bacterial colonization, disease or disorder.", "Such amelioration only requires a reduction or alteration, not necessarily elimination.", "As used herein, the terms “therapeutically effective amount” “therapeutic amount” and “pharmaceutically effective amount” are synonymous.", "One of skill in the art can readily determine the proper therapeutic amount.", "The term “substituted” as used herein, refers to all permissible substituents of the compounds.", "In the broadest sense, the permissible substituents include acyclic and cyclic, branched and unbranched, carbocyclic and heterocyclic, aromatic and nonaromatic substituents of organic compounds.", "Illustrative substituents include, but are not limited to, halogens, hydroxyl groups, or any other organic groupings containing any number of carbon atoms, preferably 1-14 carbon atoms, and optionally include one or more heteroatoms such as oxygen, sulfur, or nitrogen grouping in linear, branched, or cyclic structural formats.", "Representative substituents include alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, halo, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, sulfonyl, substituted sulfonyl, sulfonic acid, phosphoryl, substituted phosphoryl, phosphonyl, substituted phosphonyl, polyaryl, substituted polyaryl, C3-C20 cyclic, substituted C3-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, and polypeptide groups.", "“Treatment”, “treating”, or “alleviating” as used in connection with a disease or infection refers to an intervention performed with the intention of altering or inhibiting the pathology of a disorder.", "II.", "Aspects of the Invention Although aspects of the invention are described throughout the application, some of the main aspects, which all make use of the compounds of the present invention as described further in section III.A of this application, can be summarized as: (i) Enhancement of animal growth; (ii) Potentiating the effect of antibiotics and other antimicrobial agents, and addressing antibiotic resistance; (iii) Inhibition of formation, and treatment of preformed, biofilms; treating microbial infections reducing microbial colonization; and disinfecting surfaces; (iv) Compounds of the present invention as described in section III.A of this application, and compositions comprising one or more of said compounds.", "These aspects, and further aspects of the present invention, and further embodiments of these aspects, will be discussed in more detail below.", "A. Enhancement of Animal Growth A first aspect of the present invention is based on the surprising finding that compounds of the present invention as described further in section III.A of this application, can be used to enhance animal growth.", "Numerous examples of this effect are provided in Example 18 of the present application, as discussed further below.", "Accordingly, the first aspect of the present invention provides a method of enhancing the growth of an animal, the method comprising causing the animal to ingest and/or absorb an effective amount of one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below.", "In other words, the first aspect of the present invention also provides for the use of one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, for enhancing the growth of an animal, by causing the animal to ingest an effective amount of the one or more compounds.", "Typically, in the practice of the first aspect of the present invention, the one or more compounds will be presented directly to the animal for ingestion and/or absorption.", "However, in one alternative optional embodiment of the first aspect of the present invention, the animal may be caused to ingest or absorb the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, by providing the animal simultaneously, separately or sequentially with components which cause the animal to form an effective amount of the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, in situ.", "For example, the animal could be provided with a source of ferrous sulfate and simultaneously, separately or sequentially with a source of quinic acid or salt thereof (or other α-hydroxyacid), or could be provided with a source of ferrous sulfate and simultaneously, separately or sequentially with a source of a natural or synthetic amino acid, such as L-tyrosine, L-DOPA or L-phenylalanine.", "In a preferred option of the first aspect of the present invention, the animal to ingests and/or absorbs one or more compounds having the structure of Formula A as described further in section III.A of this application below, and in a further preferred option the one or more compounds are selected from the group consisting of a complex of an amino acid with Fe III and a complex of an α-hydroxyacid with Fe III, or salts and/or hydrates thereof.", "In particularly preferred options of the first aspect of the present invention, the one or more compounds may, or may not, be selected from any one or more of the group consisting of a complex of quinic acid with Fe III (such as a complex having the structure of Formula IX), a complex of L-tyrosine with Fe III (such as a complex having the structure of Formula VIII), a complex of L-DOPA with Fe III (such as a complex having the structure of Formula VII), and a complex of L-phenylalanine with Fe III.", "Accordingly, in one embodiment of the first aspect of the invention, a complex of L-tyrosine with Fe III (such as a complex having the structure of Formula VIII) is particularly preferred.", "Optionally, the one or more compounds is not a complex of quinic acid with Fe III (such as a complex having the structure of Formula IX).", "The animal may be caused to ingest or absorb the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, by providing the one or more compounds (or component parts thereof to form the compound(s) in situ) by dietary means, such as in or mixed with an animal feed, as a dietary supplement, and/or in a drinking water.", "A further option, in the case of marine, aquatic, amphibious or other animals that live partially or fully in water, is to add the one or more compounds (or component parts thereof to form the compound(s) in situ) into the water, such as by treatment of ponds containing farmed fish or crustaceans such as shrimp and crawfish.", "Accordingly, for example, in a preferred embodiment, the one or more compounds may be presented to the animal through one or more routes selected from the group consisting of an animal feed, an animal feed supplement, and in drinking water or by exposure to other water.", "It should be noted that, dependent on the solubility of the one or more compounds used, it may be beneficial to introduce a co-solvent to solubilize to aid dissolution in water at an effective concentration.", "Accordingly, in a further embodiment of the first aspect of the present invention, there is provided an animal feed, animal feed supplement and a drinking water supply, each comprising one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below.", "Suitable concentrations of the one or more compounds to include in the animal feed, animal feed supplement and a drinking water supply include concentrations as discussed further below.", "Also provided herewith, in a further embodiment of the first aspect of the present invention, is a method for the production of an animal feed product or animal feed supplement product, the method comprising the steps of incorporating one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, into the animal feed product or animal feed supplement product during the preparation of the feed or supplement.", "The one or more compounds may be incorporated into the product at any stage during the production process and may, for example, be included before one or more heating steps, such a one or more heating steps that comprise exposing a composition comprising the one or more compounds to a temperature of greater than 50° C., greater than 60° C., greater than 70° C., greater than 80° C., greater than 90° C. or greater than 100° C., and preferably wherein the temperature exposure is in a range selected from 50-200° C., 60-150° C., 70-100° C. In some embodiments, a temperature range for a heating step may be in the range of 70-90° C., such as 75-88° C., 80-87° C., 81-86° C., or 82-85° C. Optionally, in one embodiment, a suitable method for the production of an animal feed, such as a feed for a chicken (including a broiler chicken) may include the steps of: (a) combining nutritional and/or other dietary components (such as one or more components selected from wheat, soy, soy oil, minerals and other additives) to form a grist or other mixture; (b) heating the grist or other mixture in a heating step as described above, such as with steam at 85° C. for a time effective to kill any pathogens, such as Salmonella.", "A period of 5-10 minutes, such as 6-8 minutes, is one example of an effective period at 85° C., although the time can be adjusted dependent on the temperature used; (c) cooling the heated mixture.", "Preferably the cooling is conducted at a rate and under conditions effective to avoid the formation of condensation, since condensation can result in the growth of pathogens including Salmonella.", "(d) optionally pressing the cooled mixture; (e) forming feed pellets from the cooled mixture, such as by pelletizing using an extruder that heats the feed to a suitable temperature, as discussed above, for example in the range of 82-85° C.; (f) addition of heat sensitive additives, typically by spraying.", "Heat sensitive additives can include enzymes, which may (for example) be selected from the group consisting of phytase, xylase, beta-lactamase.", "In accordance with the foregoing method for the production of an animal feed product, the method comprising the step of incorporating one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, into the animal feed product at any one or more stages of the production, including during step (a), between steps (a) and (b), during step (b), between steps (b) and (c), during step (c), between steps (c) and (d), during step (d), between steps (d) and (e), during step (e), between steps (e) and (f), during step (f), or after step (f).", "Other additives which may be included either at the time of adding the heat-sensitive additives, or at earlier stages, include one or more additives selected from the list consisting of creatine, amino acids (e.g.", "threonine) and salt.", "An animal feed or animal feed supplement as described herein and useful in the context of the first aspect of the present invention, or any other aspect of the present invention, may either be a vegetarian or non-vegetarian product.", "A vegetarian product contains no meat or fish products.", "A non-vegetarian diet may contain either, or both, fish product (such as fish meal) or meat product (such as meat derivatives, bone meal, etc.).", "Also provided herewith, in a further embodiment of the first aspect of the present invention, is a method for the production of an animal drinking water, the method comprising the addition of one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, into an animal drinking water supply.", "Suitable concentrations of the one or more compounds in a drinking water supply are as discussed below, and are typically in a concentration effective to produce the effect of enhanced growth in accordance with the first aspect of the present invention.", "A determination of a suitable concentration may take into account the amount of drinking water consumed by the animal.", "For example, a broiler chicken in the UK (or at an equivalent temperature to those used in the UK) typically consumes a daily amount of drinking water dependent on its age that can be calculated by reference to the age of the chicken in days multiplied of approximately 4-10 mL, such as 5-9 ml, 6-8 mL, for example about 7.14 mL.", "Thus, for example, a 42 day old broiler chicken may have a daily water consumption of 168 mL to 420 mL per day, more typically around 300 mL per day ±30%, 20%, 15%, 10%, 5%, 4%, 3%, 2%, or 1%.", "Broiler chicken reared at different temperatures may consume more (e.g.", "in southern USA, where temperatures in the summer will be high and water consumption could be higher, particularly in sheds where temperature is not controlled), or less water.", "The animal may ingest or absorb an effective amount of one or more compounds on a regular and repeated basis.", "For example, the animal may ingest or absorb an effective amount of one or more compounds weekly, every other day, every day, or more than once every day during the performance of the method or use.", "In one option, the one or more compounds are included in the an animal feed, an animal feed supplement, and/or in drinking water and the animal ingests the one or more compounds when they eat and/or drink, and optionally every time they eat and/or drink.", "This ingestion or absorption an effective amount of one or more compounds may continue through a period of time of the animal's growth that may correspond to a period of time that is, is up to, or is at least, 5%, 10%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% or substantially 100% of the life of the animal from birth to death.", "The ingestion or absorption an effective amount of one or more compounds may start on the day of the animal's birth, or at the age of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47 days, or more.", "After the animal starts to ingest or absorb the one or compounds, the animal may continue to do so on a regular and repeated basis for a period of time that can be, or be up to, or at least, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47 days, or more.", "In the case of chickens, especially broiler chickens, it may be preferred that the chickens ingest one or more compounds in accordance with the present invention on a repeated and regular basis in a starter diet, in a grower diet and/or in a finisher diet, as described further below.", "Chickens grown for other purposes, such as breeder chickens and/or egg layer chickens, typically receive diets that are different to the broiler chicken, as discussed further in this application and standard diets for breeder and egg layer chickens are well known to those skilled in the art.", "In accordance with further embodiments of the first aspect of the present invention, the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, is incorporated into an animal feed for a breeder chicken and/or egg layer chicken.", "In an embodiment of the first aspect of the present invention, the one or more compounds may be included in an animal feed, or in an animal feed supplement, for the feed of commercial birds such as chickens, turkeys, pheasants, and ducks.", "In one option, the one or more compounds may be included in, or used to supplement, a poultry feeds, which can be a “complete” feed.", "A complete feed is designed to contain all the protein, energy, vitamins, minerals, and other nutrients necessary for proper growth, egg production, and health of the birds.", "Feeding any other ingredients, mixed with the feed or fed separately, beyond the use of a complete feed, can upset the balance of nutrients in the “complete” feed.", "Feeding additional grain or supplement with the complete poultry feed is not recommended.", "Chickens used in optimized commercial broiler production are typically fed different diets depending upon their age.", "For example, chickens for broiler production may be raised using three diets.", "These diets are typically called a “starter”, “grower” and “finisher”.", "“Pre-starter” diets are also possible.", "The “starter”, “grower” and “finisher” are typically distinguished by crude protein content, which is often provided by ingredients such as soybean meal (SBM).", "For example, a starter diet for a broiler chicken may optionally contain a crude protein contents of around 22-25% by weight, such as 22%, 23%, 24% or 25%, with 23 or 25% being preferred.", "In a further example, a grower diet for a broiler chicken may optionally contain a crude protein contents of around 21-23% by weight, such as 21%, 22% or 23%, with 22% being preferred.", "In a further example, a finisher diet for a broiler chicken may optionally contain a crude protein contents of around 19-23% by weight, such as 19%, 20%, 21%, 22% or 23%, with 19%, 20%, or 21% being preferred.", "Additionally or alternatively, the “starter”, “grower” and “finisher” may be distinguished by metabolizable energy (ME) content, which is typically lowest for the starter diet and highest for the finisher diet, with the grower diet having a level between the two.", "For example, a starter diet for a broiler chicken may have an ME of about 3000 or 3025 kcal/kg (±50, 40, 30, 20, 10, 5 or less kcal/kg).", "In a further example, a grower diet for a broiler chicken may have an ME of about 3100 or 3150 kcal/kg (±50, 40, 30, 20, 10, 5 or less kcal/kg).", "In a further example, a grower diet for a broiler chicken may have an ME of about 3200 kcal/kg (±50, 40, 30, 20, 10, 5 or less kcal/kg).", "Animal feeds, including chicken and most particularly broiler chicken feeds, in accordance with the present invention may also typically contain one or more (preferably all) of the following: Macro minerals, which include those selected from the group consisting of calcium, phosphorus, magnesium, sodium, potassium and chloride.", "Trace Minerals, including zinc and/or selenium.", "Added vitamins, which include those selected from the group consisting of vitamin A, nicotinic acid, pantothenic acid, pyridoxine (B6) and biotin in maize and wheatbased feed.", "Additionally there is a basic requirement of broiler chickens for vitamin E at 10-15 mg/kg.", "The need for extra supplementation with vitamin E will depend on the level and type of fat in the diet, on the level of selenium and on the presence of pro- and antioxidants.", "Heat treatment of feeds can result in the destruction of up to 20% of vitamin E Choline may also be given in a complete feed.", "Non-nutritive feed additives may also be included.", "Enzymes are routinely used in poultry feeds to improve digestibility of feed ingredients.", "In general, feed enzymes are available that act on carbohydrates, plant bound minerals and proteins.", "Non Starch Polysaccharide (NSP) enzymes are economically beneficial in wheat-based feeds.", "These enzymes will also allow greater flexibility in the levels of barley to be included in the ration.", "Phytase enzymes can be used to enhance phytate phosphorus utilization.", "Protease enzymes can be included to act upon vegetable products.", "Carbohydrase enzymes can be added, and may provide beneficial responses when used in maize-soya diets.", "When adding enzymes before heat processing of broiler feeds, there is the potential for a loss in enzyme activity.", "This may be avoided by spraying enzymes on to the feed at the end of processing.", "Medicinal and prophylactic drugs (other than the compounds as defined in section III.A.", "below) may be added.", "A wide range of medicinal products, e.g.", "coccidiostats and antibiotics, may be administered through the feed.", "Antibiotic Growth Promoters/Digestion Enhancers can be included and can, for example, provide a mode of action involving modification of the gut microflora, with consequential benefits in nutrient utilization.", "Prebiotics can be added, and refer to a group of substances which stimulate the growth of beneficial microorganisms, at the expense of harmful, micro-organisms.", "Oligosaccharides form the largest group of these products at present.", "Probiotics can be added to introduce live micro-organisms into the digestive tract to assist the establishment of a stable and beneficial microflora.", "The objective is to provide the gut with positive, non-pathogenic micro-organisms which will then prevent colonization with pathogenic micro-organisms by competitive exclusion.", "Organic Acids may be added.", "Organic acid products can be used to reduce bacterial contamination of the feed (e.g.", "after heat treatment) and can also encourage beneficial microflora to develop in the digestive tract of the bird.", "Absorbents are used specifically to absorb mycotoxins.", "They may also have a beneficial effect on general bird health and nutrient absorption.", "There are a range of products available for use as absorbents, including various clays and charcoal.", "Antioxidants can provide important protection against nutrient loss in broiler feeds.", "Some feed ingredients e.g.", "fish meal and fats, can be protected.", "Vitamin premixes should be protected by an antioxidant unless optimum storage times and conditions are provided.", "Additional antioxidants may be added to the final feed where prolonged storage or inadequate storage conditions are unavoidable.", "Anti-Mold Agents can be added.", "For example, mold inhibitors may be added to feed ingredients, which have become contaminated, or to finished rations to reduce growth of fungi and production of mycotoxins.", "Pelleting agents can be added, and are used to improve pellet hardness.", "Some examples of pellet binders are hemicellulose, bentonite and guar gum.", "Other products of possible use in broiler production include essential oils, nucleotides, glucans and specialized plant extracts.", "In areas of the world where its use is permitted, formaldehyde can be used to treat/preserve feed.", "Without limitation, exemplary “starter”, “grower” and “finisher” diets include those shown in Example 18 of this application, below.", "The starter diet with broiler chicks may be fed for about the first 10-12 days (typically in the range of the first 7-14 days of life).", "This starter diet may be followed by the grower diet, which is provided to the broilers for almost 2 weeks (typically from the age of about 11-24 days, although in any case, after the end of the use of the starter diet).", "The finisher diet may be used for the remainder of the production period (typically from the age of about 24, or 25, days to harvest).", "Some broiler houses will use more or less diets (for example 4 diets), and vary the timing of diet changes.", "Broilers are typically harvested between 35 and 42 days, although this time can be longer or shorter.", "The UK market typically harvests at day 30-35.Other countries, including some European countries, harvest as early as 25 days, although more typically from 30 days onwards.", "Yet other countries, such as the US, typically harvest at 42-47 days.", "Non-broiler chickens, including free-range chickens, may be harvested at later ages.", "In the context of the practice of the first aspect of the present invention, any age of harvest may be used, although most typically (e.g.", "in the context of broiler chickens) after the start of the finisher diet, and optionally (and without limitation) on any of days 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70 or beyond, such as up to or about 11 weeks, 12 weeks, 13 weeks, 14 weeks, 15 weeks, 16 weeks, 17 weeks, 18 weeks, 19 weeks, 20 weeks or more.", "In some embodiments of the first aspect of the present invention, methods for the production of broiler chicken or other animals may be performed on groups that are single sex (i.e.", "groups of solely female, or solely male animals), and/or may be performed on groups of mixed sex (i.e.", "mixed male and female) animals.", "For example, in the case of the production of broiler chickens, it may be appropriate to select and rear together a single sex group of male cockerels, and it may be suitable to harvest the cockerels at an earlier age than female or mixed sex groups.", "For example, a single sex cockerel group of broiler chickens may be harvested at the age of around 30 days or, in other options, at the age of any one or more of 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, or more days.", "For example, at the age of 30 days, an untreated cockerel group may have an average target weight of about 1.95 kg, whereas in the case of the enhanced growth resulting from the performance of the method of the first aspect of the present invention, it may be appropriate to harvest the cockerels at an earlier stage at the defined target weight, or to harvest at the same age and a higher average weight, or at the same age and target weight with the use of a reduced consumption of animal feed due to greater feed conversion efficiency.", "In a further example, a mixed sex group of broiler chickens may be harvested at the age of around 35 days or, in other options, at the age of any one or more of 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50 or more days.", "For example, at the age of 35 days, an untreated mixed sex group may have an average target weight of about 2.1-2.2 kg, whereas in the case of the enhanced growth resulting from the performance of the method of the first aspect of the present invention, it may be appropriate to harvest the mixed sex group at an earlier stage at the defined target weight, or to harvest at the same age and a higher average weight, or at the same age and target weight with the use of a reduced consumption of animal feed due to greater feed conversion efficiency.", "In accordance with the practice of the first aspect of the invention, for the purpose of enhancing the growth of broiler chickens, the one or more compounds may be included in any one, two or three of the starter, grower and finisher diets.", "In one embodiment, the one or more compounds may be included in starter diet only.", "In another embodiment, the one or more compounds may be included in grower diet only.", "In another embodiment, the one or more compounds may be included in finisher diet only.", "In another embodiment, the one or more compounds may be included in starter and grower diets only, but not the finisher diet.", "In another embodiment, the one or more compounds may be included in starter and finisher diets only, but not the grower diet.", "In another embodiment, the one or more compounds may be included in grower and finisher diets only, but not the starter diet.", "In another embodiment, the one or more compounds may be included in all of the starter, grower and finisher diets.", "In accordance with further embodiments of the first aspect of the present invention, the animal to be grown may be an egg-laying chicken.", "A typical process of rearing an egg-laying chicken can involve the beginning of egg production at around 23 weeks of age, and slaughter at around 60 weeks of age.", "The egg-laying chicken may be treated in accordance with the first aspect of the present invention prior to beginning egg laying, and/or during egg laying, and/or up to the time of slaughter.", "Treatment may, for example, last for about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, or 60 weeks; the term “about” in that context can include the meaning of ±4, 3, 2, or 1 weeks of the stated value.", "Whereas, typically, egg laying chickens begin to lay eggs at 23 weeks of age, by taking advantage of the enhanced growth and/or enhanced feed utilization of the first aspect of the present invention, it may be appropriate to begin egg production at an earlier age, such as at 18, 19, 20, 21 or 22 weeks of age.", "Further, by taking advantage of the enhanced growth and/or enhanced feed utilization of the first aspect of the present invention, the present invention may be used to achieve an effect (compared to an untreated control group that is reared under identical conditions except for the application of the method of the first aspect of the present invention) selected from: (a) the production with eggs of improved quality.", "Improved quality may, for example, be selected from size, shell quality, air cell, white and yolk.", "The shell quality is determined from any one or more of size, visual defects, specific gravity, color, breaking strength, percent shell (shell weight×100/egg weight), shell thickness, and ultrastructure of the egg.", "The improved quality may be reflected in a higher proportion of eggs being categorized as US grade A or AA (for example, the US standard for grading eggs is discussed at http://www.fao.org/docrep/005/y4628e/y4628e04.htm, the contents of which are incorporated herein by reference); (b) the production of eggs of increased size (such as at a weight that is up to, or at least, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 15%, 20% or more); and/or (c) the production of eggs in increased numbers (such as in an average daily amount, per group of at least 100 animal and/or when assessed over a period of at least 10 days, that is an amount that is up to, or at least, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 15%, 20% or more).", "The same approach can be taken with other egg-laying animals.", "Eggs produced by egg-laying chickens and other animals are labelled with information to indicate the source and date/or of origin.", "Also provided by the present invention, in accordance with a further embodiment of the first aspect, are one or more eggs, such as a box or carton of eggs, produced by the animals (especially egg-laying chickens) that have been treated by a method according to the first aspect of the present invention.", "As indicated above, such eggs will typically carry a label indicating their source and/or date of origin.", "Also provided are downstream products, especially food products, produced from and/or containing eggs or parts thereof produced by the animals (especially egg-laying chickens) that have been treated by a method according to the first aspect of the present invention.", "An animal feed of, or for use in, a first aspect of the present invention may comprise, or be supplemented with, one or more compounds of the present invention in an amount of 0.001 to 20 g of the one or more compounds per kg of feed, such as 0.002 to 15 g/kg, or at a level of, up to, or at least, about 0.002 g/kg, 0.005 g/kg, 0.01 g/kg, 0.02 g/kg, 0.03 g/kg, 0.04 g/kg, 0.05 g/kg, 0.1 g/kg, 0.2 g/kg, 0.3 g/kg, 0.4 g/kg, 0.5 g/kg, 1 g/kg, 2 g/kg, 3 g/kg, 4 g/kg, 5 g/kg, 10 g/kg, 15 g/kg or 20 g/kg.", "An animal drinking water supply of, or for use in, the first aspect of the present invention may comprise, or be supplemented with, one or more compounds of the present invention in an amount of 0.001 to 20 g of the one or more compounds per L of water, such as 0.002 to 15 g/L, or at a level of, up to, or at least, about 0.002 g/L, 0.005 g/L, 0.01 g/L, 0.02 g/L, 0.03 g/L, 0.04 g/L, 0.05 g/L, 0.1 g/L, 0.2 g/L, 0.3 g/L, 0.4 g/L, 0.5 g/L, 1 g/L, 2 g/L, 3 g/L, 4 g/L, 5 g/L, 10 g/L, 15 g/L or 20 g/L.", "The same concentrations can apply to water in which aquatic or other animals live.", "Optionally, the methods and uses of the present invention are conducted such that, during the course of the treatment, the animal ingests and/or absorbs a daily mean average total of FeQ (or an equivalent number of moles of any other one or more compounds according to Formula A or B, or other compounds of the invention as described further in section III.A of this application below) of, of up to, or at least, about 100 μg, 500 μg, 1 mg, 10 mg, 100 mg, 1 g, 2 g, 3 g, 4 g, or 5 g. In an additional or alternative option, the methods and uses of the present invention are conducted such that, during the course of the treatment, the animal ingests and/or absorbs a total of FeQ (or an equivalent number of moles of any other one or more compounds according to Formula A or B, or other compounds of the invention as described further in section III.A of this application below) of, of up to, or at least, about (a) 5 mg, 10 mg, 50 mg, 100 mg, 500 mg, 1 g, 5 g, 10 g, 50 g or 100 g per individual animal and/or (b) 1 mg, 2 mg, 3 mg, 4 mg, 5 mg, 10 mg 50 mg, 100 mg, 200 mg, 300 mg, 400 mg, 500 mg, 600 mg, 700 mg, 800 mg, 900 mg, 1 g, 1.1 g, 1.2 g, 13 g, 1.4 g, 1.5 g, 1.6 g, 1.7 g, 1.8 g, 1.9 g, 2 g, 2.1 g, 2.2 g, 2.3 g, 2.4 g, 2.5 g, 2.6 g, 2.7 g, 2.8 g, 2.9 g, 3 g, 3.5 g, 4 g, 4.5 g, 5 g, 6 g, 7 g, 8 g, 9 g, 10 g, 20, g, 30 g, 40 g, 50 g, 60 g, 70 g, 80 g, 90 g or 100 g per kg of final average body weight, as determined at the day of the final administration of the one or more compounds.", "Accordingly, the present invention also provides animal feed, animal feed supplements, drinking water supplies, and ponds (or other contained water-based growth areas) for use in accordance with the present invention, and comprising the one or more compounds according to Formula A or B, or other compounds of the invention as described further in section III.A of this application below, at the one of the concentrations indicated above.", "Exemplary animal feeds of the present invention include chicken feeds, including (i) starter diets, grower diets and/or finisher diets, particular for a meat-type chicken such as broiler chicken, or (ii) for egg-laying chicken such as a pullet or hen, or (iii) for breeder chickens.", "Also included are feeds for other poultry, such as a turkey, geese, quail, pheasant, or ducks, or livestock, such as cattle, sheep, goats or swine, alpaca, banteng, bison, camel, cat, deer, dog, donkey, gayal, guinea pig, horse, llama, mule, rabbit, reindeer, water buffalo, yak, although the skilled person will appreciate that other feeds for animals, including zoo animals, captive animals, game animals, fish (include freshwater and saltwater fish, farmed fish, and ornamental fish), other marine and aquatic animals, including shellfish such as, but not limited to, oysters, mussels, clams, shrimps, prawns, lobsters, crayfish, crabs, cuttlefish, octopus, and squid, domestic animals such as cats and dogs, rodents (such as mice, rats, guinea pigs, hamsters), and horses, are also provided, as well as any other domestic, wild and farmed animal, including mammals, marine animals, amphibians, birds, reptiles, insects and other invertebrates.", "In one embodiment, in the context of the first aspect of the present invention, the animal may be selected from the group consisting of poultry, such as a chicken, turkey, geese, quail, pheasant, or ducks, or livestock, such as cattle, sheep, goats or swine, alpaca, banteng, bison, camel, cat, deer, dog, donkey, gayal, guinea pig, horse, llama, mule, rabbit, reindeer, water buffalo, yak, although the skilled person will appreciate that other animals, including zoo animals, captive animals, game animals, fish (include freshwater and saltwater fish, farmed fish, and ornamental fish), other marine and aquatic animals (including shellfish such as, but not limited to, oysters, mussels, clams, shrimps, prawns, lobsters, crayfish, crabs, cuttlefish, octopus, and squid), domestic animals such as cats and dogs, rodents (such as mice, rats, guinea pigs, hamsters), and horses, as well as any other domestic, wild and farmed animal, including mammals, marine animals, amphibians, birds, reptiles, insects and other invertebrates may also be treated.", "In a particularly preferred embodiment, the animal is a chicken, for example, a meat-type chicken such as broiler chicken, or an egg-laying chicken such as a pullet or hen, or a breeder chicken.", "The method of enhancing the growth of an animal in accordance with the first aspect of the present invention may be practiced on multiple animals, which may optionally be reared together and, further optionally wherein all animals reared together may be aged matched to within a month, a week, or less, such as within 6, 5, 4, 3, 2 or 1 days of each other.", "For example, the method may be practiced on a group of up to, about, or at least, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 100, 150, 200, 250, 300, 400, 500, 600, 700, 800, 900, 1×103, 2×103, 3×103, 4×103, 5×103, 6×103, 7×103, 8×103, 9×103, 1×104, 2×104, 3×104, 4×104, 5×104, 6×104, 7×104, 8×104, 9×104, 1×105, 2×105, 3×105, 4×105, 5×105, 6×105, 7×105, 8×105, 9×105, 1×106 or more, and all animals in the group may be optionally age matched as indicated above.", "The term “about” in this context can mean within ±50%, ±40%, ±30%, ±20%, ±10%, ±5%, ±4%, ±3%, ±2%, ±1% or less of the stated value.", "The animals treated in accordance with the present invention may be healthy animals, for example, animals which are not infected with or disadvantageously colonized by bacteria or other microorganisms.", "In another embodiment, the animals treated in accordance with the present invention may be unhealthy animals, for example, animals which are infected with and/or disadvantageously colonized by bacteria or other microorganisms.", "An example of a disadvantageous bacterial colonization is Campylobacter colonization in the GI tract of chickens; Campylobacter is not pathogenic and does not cause disease in the chicken itself (although of course it can lead to food poisoning if present in a downstream meat product produced from the chicken)—nevertheless, the Campylobacter colonization can be considered disadvantageous to the chicken as it reduces its ability to grow or efficiently utilize feed.", "As such, in one embodiment, an animal that is disadvantageously colonized by bacteria or other microorganisms is an animal which displays a reduced rate of growth, reduced body weight, reduced weight gain, or less efficient feed conversion ratio due to the colonization, compared to a control animal that differs only in that it does not have the colonization.", "In some embodiments, the animals treated in accordance with the present invention may be animal that have been exposed to the litter (including feacal matter) of one or more other animals of the same or different species.", "Optionally, the litter may be from unhealthy animals which, for example, animals which are infected with and/or disadvantageously colonized by bacteria or other microorganisms.", "In one embodiment of interest to the present invention, the animals treated may be chickens, such as broiler chickens, and they may have been exposed to the litter of other chickens, such as dirty litter as described in the present examples and/or carrying one or more pathogens, such as Actinobacillus, Bordetalla, Campylobacter, Clostridium, Corynebacterium, Escherichia coli, Globicatella, Listeria, Mycobacterium, Salmonella, Staphylococcus, and Streptococcus.", "As such, the animals to be treated in accordance with the present invention may be chickens (or other animals) that are infected and/or colonized by one or more of the foregoing pathogens.", "Accordingly, in some embodiments, the methods and uses of the present invention may be non-therapeutic, in the sense that the animal to be treated is healthy and/or the method and use comprises the eventual slaughter of the animal.", "In other embodiments, the methods and uses of the present invention may include therapeutic benefits to the animals to be treated.", "In one embodiment, the methods and uses of enhancing the growth of an animal in accordance with the first aspect of the present invention can include enhancing one or more characteristics selected from the group consisting of enhancing body weight or (in the case of a group of animals) average body weight (ABW), feed intake or (in the case of a group of animals) average feed intake (AFD), weight gain or (in the case of a group of animals) average weight gain (AWG), feed conversion ratio (FCR) and/or mortality adjusted feed conversion ratio (MFCR).", "In one embodiment (for example, in the context of a group of chickens grown in a pen) MFCR over a given period can be calculated as follows: MFCR=Total feed intake of period per pen/((total live weight of pen+total weight of dead birds in pen)−total live weight of pen in previous period) For example for period 0 to 20 day, MFCR can be calculated as: MFCR0 to 20 day=Total feed intake0-20 days/((Total body weightat day 20+mortality weight0-20 days)−Total body weightday 0).", "The enhancement in growth of the animal may be assessed over any convenient period during the animal's growth.", "It may, for example, be assessed from birth to a predetermined time point, such as up to about 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 or more days.", "The term “about” in this context can mean±5, ±4, ±3, ±2, or ±1 days.", "It may, for example, be assessed from birth to a predetermined time point, such as up to about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99% or 100% of the life span of the animal.", "It may, alternatively, not be measured from birth but be measured over a period of the animal's life lasting up to about 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 or more days.", "Again, the term “about” in this context can mean±5, ±4, ±3, ±2, or ±1 days.", "It may, alternatively, not be measured from birth but be measured over a period of the animal's life representative of about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, or 99% of the life span of the animal.", "In the context of using the first aspect of the present invention to enhance the growth of broiler chickens, which are typically slaughtered at the average age of 35 days (in the EU) and 47 days (in the US), enhanced growth may be measured from birth up to the age of slaughter, or may be measured up to an earlier age, such as up to 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46 or 47 days.", "Alternatively, the enhanced growth of broiler chickens may not be measured from birth but may be over another period of the broiler chicken's life lasting, for example, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46 or 47 days.", "Enhanced growth can, in some embodiments, refer to an enhancement in growth in a subject animal compared to a control which is the same breed of animal as the subject, or an enhancement in a subject group of animals compared to a control group of an equivalent number of animals of the same breed as the subject group, wherein the subject and control are the same age or average age (ideally within a margin of error of less than one day), wherein growth is measured over the same period of time (ideally within a margin of error of less than one day), and wherein the subject and control are reared under the same conditions, differing only in that the subject receives one or more compounds of the present invention, in particular one or more compounds according to Formula A or B, or other compounds of the invention as described further in section III.A of this application below, whereas the control does not.", "In the context of using the present invention to enhance the growth of animals, and in particular poultry, such as chickens and more preferably broiler chickens, an enhancement in the rate of growth may constitute a reduction in the MFCR of the subject by, by up to, or by at least, about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.11, 0.12, 0.13, 0.14, 0.15, 0.16, 0.17, 0.18, 0.19 or 0.20.The term “about” in this context may include the meaning of ±5×10−3.The reduction in MFCR may, for example, be measured between days 0 to 20, or days 20 to 42 of the life of the animal(s).", "Under current economic conditions, it can be calculated that a reduction in MFCR of 0.1 will lead to an approximate saving in feed cost of about 4 US cents per bird over a 42 day growth period and/or about £10 GBP per tonne of animal feed used.", "It will be appreciated that these are substantial savings in an industry in which costs are typically controlled at a level of about 0.01 US cents per bird.", "Further, in the context of using the first aspect of the present invention to enhance the growth of animals, and in particular poultry, such as chickens and more preferably broiler chickens, an enhancement in the rate of growth may constitute an increase in the ABW of the subject by, by up to, or by at least, about 10 g, 20 g, 30 g, 40 g, 50 g, 60 g, 70 g, 80 g, 90 g, 100 g, 110 g, 120 g, 130 g, 140 g, 150 g, 160 g, 170 g, 180 g, 190 g, 200 g, 210 g, 220 g, 230 g, 240 g, 250 g or more.", "The term “about” in this context may include the meaning of ±5 g, 4 g, 3 g, 2 g or 1 g. The increase in the ABW may, for example, be measured between days 0 to 20, or days 20 to 42 or the life of the animal(s).", "In the context of animals that normally (i.e.", "when not treated in accordance with the present invention) have a higher ABW than the normal ABW of broiler chickens (i.e.", "when not treated in accordance with the present invention), then the foregoing values may be increased proportionately.", "That is, for example, in the case of an animal that has a normal ABW 10-fold greater than the normal ABW of a broiler chicken, then the enhancement in the rate of growth provided by the present invention may constitute an increase in the ABW of the subject by, by up to, or by at least, about 100 g, 200 g, 300 g, 400 g, 500 g, 600 g, 700 g, 800 g, 900 g, 1000 g, 1100 g, 1200 g, 1300 g, 1400 g, 1500 g, 1600 g, 1700 g, 1800 g, 1900 g, 2000 g, 2100 g, 2200 g, 2300 g, 2400 g, 2500 g or more, wherein the term “about” in this context may include the meaning of ±50 g, 40 g, 30 g, 20 g or 10 g. Further, in the context of using the first aspect of the present invention to enhance the growth of animals, and in particular poultry, such as chickens and more preferably broiler chickens, an enhancement in the rate of growth may constitute an increase in the average weight gain (AWG) of the subject by, by up to, or by at least, about 10 g, 20 g, 30 g, 40 g, 50 g, 60 g, 70 g, 80 g, 90 g, 100 g, 110 g, 120 g, 130 g, 140 g, 150 g, 160 g, 170 g, 180 g, 190 g, 200 g, 210 g, 220 g, 230 g, 240 g, 250 g, 260 g, 270 g, 280 g, 290 g, 300 g or more over a period of growth, compared to a control animal or group of animals.", "The term “about” in this context may include the meaning of ±5 g, 4 g, 3 g, 2 g or 1 g. The increase in the AWG may, for example, be measured between days 0 to 20, or days 20 to 42 of the life of the animal(s), or during a period of time selected from 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46 or 47 days.", "In the context of animals that normally (i.e.", "when not treated in accordance with the present invention) show a higher AWG than the normal AWG of broiler chickens (i.e.", "when not treated in accordance with the present invention), then the foregoing values may be increased proportionately.", "That is, for example, in the case of an animal that has a normal AWG 10-fold greater than the normal AWG of a broiler chicken over an equivalent period of time, then the enhancement in the rate of growth provided by the present invention may constitute an increase in the AWG of the subject by, by up to, or by at least, about 100 g, 200 g, 300 g, 400 g, 500 g, 600 g, 700 g, 800 g, 900 g, 1000 g, 1100 g, 1200 g, 1300 g, 1400 g, 1500 g, 1600 g, 1700 g, 1800 g, 1900 g, 2000 g, 2100 g, 2200 g, 2300 g, 2400 g, 2500 g, 2600 g, 2700 g, 2800 g, 2900 g, 3000 g or more, wherein the term “about” in this context may include the meaning of ±50 g, 40 g, 30 g, 20 g or 10 g. Prior to the present invention, in the US, the average age of slaughter of a broiler chicken is 47 days at an average weight of 2.6 kg; at the age of 42 days, the average weight may be around 2.5 kg, and in the EU, the average age of slaughter of a broiler chicken 35 days at an average weight of 2.1-2.2 kg.", "It will be appreciated that, as a result of the enhanced growth provided by the methods and uses of the present invention, it will be possible to reach the target weight and harvest the animal or animal products at an earlier stage of the animal's life than would be possible with a control.", "For example, in the context of a broiler chicken, it may be possible to slaughter the animal after having achieved a target body weight 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more days earlier than a control.", "In that context, a target body weight of a broiler chicken may be, may be up to, or may be at least, about 1000 g, 1100 g, 1200 g, 1300 g, 1400 g, 1500 g, 1600 g, 1700 g, 1800 g, 1900 g, 2000 g, 2100 g, 2200 g, 2300 g, 2400 g, 2500 g, 2600 g, 2700 g, 2800 g, 2900 g, 3000 g, 3100 g, 3200 g, 3300 g, 3400 g, 3500 g or more.", "The term “about” in that context may include ±50 g, ±40 g, ±30 g, ±20 g or ±10 g of the stated value.", "To put it another way, the broiler chicken may be slaughtered at, or prior to, the age of 47, 46, 45, 44, 43, 42, 41, 40, 39, 38, 37, 36, 35, 34, 33, 32, 31, 30, 29, 28, 27, 26 or 25 days, ideally wherein it has reached a target body weight at the time of slaughter.", "Thus, for example, in one embodiment of the present invention, the broiler chicken is reared to a target weight of about 2.6 kg, and the method or use includes the step of slaughtering the animal after having achieved a target body weight 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more days earlier than the age of 47 days.", "In another exemplary embodiment, broiler chicken is reared to a target weight of about 2.5 kg, and the method or use includes the step of slaughtering the animal after having achieved a target body weight 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more days earlier than the age of 42 days.", "In another exemplary embodiment, broiler chicken is reared to a target weight of about 2.2 kg, and the method or use includes the step of slaughtering the animal after having achieved a target body weight 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more days earlier than the age of 35 days.", "In another embodiment, the animal is reared for the same amount of time as the industry standard, but presents a greater body weight (such as about, at least, or up to, 0.1%.", "0.5%.", "1%.", "2%.", "3%, 4%, 5%, 10%, 15%, 20%, 25% or more) than the industry standard at the end of the rearing process.", "Thus, in the context of broiler chickens, the animal may be slaughtered at a weight of about 1000 g, 1100 g, 1200 g, 1300 g, 1400 g, 1500 g, 1600 g, 1700 g, 1800 g, 1900 g, 2000 g, 2100 g, 2200 g, 2300 g, 2400 g, 2500 g, 2600 g, 2700 g, 2800 g, 2900 g, 3000 g, 3100 g, 3200 g, 3300 g, 3400 g, 3500 g or more, wherein at the time of slaughter body weight is about, at least, or up to, 0.1%.", "0.5%.", "1%.", "2%.", "3%, 4%, 5%, 10%, 15%, 20%, 25% or more than the control.", "The term “about” as it is applied to weight in that context may include ±50 g, ±40 g, ±30 g, ±20 g or ±10 g of the stated value.", "In yet another embodiment, as a result of the effect of the enhanced growth provided by the methods and uses of the first aspect of the present invention, the animal is able to utilize animal feeds with greater efficiency than a control.", "Accordingly, in another embodiment, the methods and uses of the present invention include the option of rearing an animal to reach a target body weight using less animal feed than is required for a control to reach the target weight.", "For example, it may be possible to use the present invention to rear an animal to reach the target weight using an amount of animal feed that is reduced in weight by 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 1%, 2%, 3%, 4%, 5%, 10%, 15%, 20%, 25% or more, compared to the amount of the same animal feed required by a control to reach the same target weight.", "In that context, a target body weight of a broiler chicken may be, may be up to, or may be at least, about 1000 g, 1100 g, 1200 g, 1300 g, 1400 g, 1500 g, 1600 g, 1700 g, 1800 g, 1900 g, 2000 g, 2100 g, 2200 g, 2300 g, 2400 g, 2500 g, 2600 g, 2700 g, 2800 g, 2900 g, 3000 g, 3100 g, 3200 g, 3300 g, 3400 g, 3500 g or more.", "The term “about” in that context may include ±50 g, ±40 g, ±30 g, ±20 g or ±10 g of the stated value.", "For example, in the context of the industry standard for rearing a broiler chicken for 42 days, it is typical to provide each chicken with total of 5.2 kg of feed throughout its life (a mean average of 123.8 g of feed per day of life).", "In such a situation, in one embodiment, the present invention involves feeding the chicken a total amount of chicken feed that is reduced from 5.2 kg, and/or reduced from a mean average of 123.8 g feed per day, by 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 1%, 2%, 3%, 4%, 5%, 10%, 15%, 20%, 25% or more, during its rearing.", "Accordingly, the methods and uses of the present invention may further comprise the step of rearing the animal to permit enhanced growth.", "A further embodiment in accordance with the first aspect of the present invention provides a method of preventing or reducing the colonization of the gastrointestinal tract of an animal (such as an animal described above) with Campylobacter and/or other bacterial or microorganisms, by causing the animal to ingest and/or absorb an effective amount of one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below.", "In particular, it relates to reduction or prevention of colonization of the gastrointestinal tract of poultry (such as types of a poultry as described above) with Campylobacter.", "It also relates to uses of one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below to prevent the bacteria from adhering to the wall of the gastrointestinal tract of animals and to treat or prevent infection by Campylobacter and/or other bacterial or microorganisms in humans and animals.", "Accordingly, in a further embodiment of the first aspect of the present invention, there is provided a method for disinfection of an animal comprising administering to said animal at least one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below in an effective amount to reduce the number of Campylobacter and/or other bacterial or microorganisms present in the gastrointestinal tract of said animal.", "A further embodiment of the first aspect of the present invention also provides a method for disinfection of an animal comprising administering to said animal at least one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below in an effective amount to prevent said Campylobacter and/or other bacterial or microorganisms from forming a biofilm in the gastrointestinal tract of said animal or to reduce the amount of biofilm formed by Campylobacter and/or other bacterial or microorganisms in the intestinal tract of said animal.", "A further embodiment of the first aspect of the present invention also provides a method for preventing or reducing transmission of Campylobacter infection, and/or infection by other bacteria or microorganisms, from one animal to another, for example preventing or reducing spread of Campylobacter and/or infection by other bacteria or microorganism, within a flock or herd of animals, for example preventing spread of Campylobacter infection and/or infection by other bacteria or microorganisms, within a flock of chickens, including broiler chickens; said method comprising administering to said animals, for example said herd or flock of animals, for example said flock of chickens, one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below in an effective amount to prevent said Campylobacter and/or other bacteria or microorganisms, from forming a biofilm in the gastrointestinal tract of said animal or to reduce the amount of biofilm formed by Campylobacter and/or other bacteria or microorganisms, in the intestinal tract of said animal.", "These methods may allow disinfection, prevention of biofilm formation and reduction of transmission of Campylobacter and/or other bacteria or microorganisms, between animals by preventing or reducing adherence of Campylobacter and/or other bacteria or microorganisms, of the gastrointestinal tract of said animals.", "This is advantageous because the fewer Campylobacter and/or other bacteria or microorganisms, that are in the gastrointestinal tract of an animal at the time of slaughter, the lower the risk of contamination of meat from the animal with Campylobacter and/or other bacteria or microorganisms.", "The fewer Campylobacter and/or other bacteria or microorganisms that are in the gastrointestinal tract of an animal the lower the chance of the Campylobacter and/or other bacteria or microorganisms, forming a biofilm in the gastrointestinal tract of the animal.", "The fewer Campylobacter and/or other bacteria or microorganisms, that are in the gastrointestinal tract of an animal, the lower the chance that the Campylobacter and/or other bacteria or microorganisms, will spread from one animal to another, for example within a herd or flock of animals.", "These methods may also be used to reduce the amount of colonisation of the gastrointestinal tract of any animal with Campylobacter and/or other bacteria or microorganisms.", "It can be particularly advantageous to provide the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below to animals that will be slaughtered for human consumption.", "Poultry includes birds that are used for human consumption such as chickens, geese, turkeys and ducks.", "It is particularly, advantageous to use the compounds of the present invention to reduce or prevent colonisation of the gastrointestinal tract of poultry, in particular chickens, and more particularly broiler chickens, egg laying chicken and/or breeder chickens, with Campylobacter and/or other bacteria or microorganisms because chickens are a leading source of human infection with Campylobacter.", "The number of Campylobacter and/or other bacteria or microorganisms in the gastrointestinal tracts of animals may be reduced by the methods of the present invention.", "In one embodiment the number of colony forming units (cfu) of Campylobacter and/or other bacteria or microorganisms in the gastrointestinal tract of an animal treated with the compounds of the present invention may be reduced by 50%, by 60%, by 70%, by 80%, by 90% or by 100%.", "In one embodiment Campylobacter and/or other bacteria or microorganisms may be substantially eradicated from the gastrointestinal tract of animals treated by the method of the present invention.", "10,000 cfu of Campylobacter are enough for successful chicken colonization.", "1,000 cfu of Campylobacter are enough to infect a human and cause disease in a human.", "Therefore, an effective amount of a compound of the present invention is enough of the compound to reduce the number of Campylobacter and/or other bacteria or microorganisms in the gastrointestinal tract of an animal to a number that is unlikely to cause infection in humans, such as less than 10,000 cfu, 5,000 cfu, 1,000 cfu, 500 cfu, 400 cfu, 300 cfu, 200 cfu, 100 cfu, 90 cfu, 80 cfu, 70 cfu, 60 cfu, 50 cfu or less.", "The number of cfu of Campylobacter and/or other bacteria or microorganisms that would be ingested by a human if they ate meat from an infected animal may be related to the number of Campylobacter and/or other bacteria or microorganisms in the gastrointestinal tract of the animal at the time of slaughter but also depends on other factors such as the amount of contamination of the meat with the contents of the gastrointestinal tract of the animal at the time of slaughter.", "An effective amount of the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, in this context, may be an amount that is enough of the one or more compounds to prevent colonisation of the gastrointestinal tract of the animal with Campylobacter and/or other bacteria or microorganisms.", "In one embodiment the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below may make Campylobacter and/or other bacteria or microorganisms less virulent and less capable of infecting humans even if the total number of Campylobacter and/or other bacteria or microorganisms in the gastrointestinal tract does not decrease.", "In this embodiment administering a compound of the present invention to an animal may affect the metabolism of Campylobacter and/or other bacteria or microorganisms and make them less adaptive to environment (for example, less motile) so that they cannot colonize the gastrointestinal tract and are less likely to be transmitted to other animals or to humans.", "An effective amount of a one or more compounds provided to an animal should be enough to provide the required degree of reduction of Campylobacter and/or other bacterial or microorganism colonisation.", "This may depend on the type of compound and/or the size of the animal.", "In one embodiment, the one of more compounds may be provided in an animal feed, animal drink, or other compositions in concentration within the range of about 1 μM to about 1M, preferably greater than 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 90 μM, 100 μM, 110 μM, 120 μM, 130 μM, 140 μM, 150 μM, 160 μM, 170 μM, 180 μM, 190 μM, 200 μM, 250 μM, 300 μM, 350 μM, 500 μM, 1 mM or more.", "For example, the concentration of the one or more compounds may be: (a) up to 1 μM, 2 μM, 3 μM, 4 μM, 5 μM, 10 μM, 15 μM, 20 μM, 25 μM, 30 μM; (b) within a range selected from the group consisting of from 35 to 335 μM, 40 to 300 μM, 50 to 300 μM, 50 to 250 μM, 50 to 200 μM, 60 to 300 μM, 60 to 250 μM, 60 to 200 μM, 80 to 300 μM, 80 to 250 μM, 80 to 200 μM, 100 to 300 μM, 100 to 250 μM, or 100 to 200 μM; or (c) at least, or about, 345 μM, 350 μM, 360 μM, 370 μM, 380 μM, 390 μM, 400 μM, 450 μM, 0.5 mM, 1 mM, 2 mM or more.", "In another embodiment, the concentration may be within a range selected from the group consisting of from about 1 μM to about 1 mM, or about 30 μM to about 0.5 mM, or about 60 μM to about 0.3 mM.", "In the case of the animal drink (such as drinking water) or other composition types, optionally, the concentration of the one or more compounds in the composition may be within the range of 0.002 to 15 g/L, or at a level of, up to, or at least, about 0.002 g/L, 0.005 g/L, 0.01 g/L, 0.02 g/L, 0.03 g/L, 0.04 g/L, 0.05 g/L, 0.1 g/L, 0.2 g/L, 0.3 g/L, 0.4 g/L, 0.5 g/L, 1 g/L, 2 g/L, 3 g/L, 4 g/L, 5 g/L, 10 g/L, 15 g/L or 20 g/L In another embodiment, the one of more compounds may be provided in an animal feed, animal drink, or other composition in a unit dosage formulation, and/or at a concentration to deliver up to, or at least, about 1 ng, 10 ng, 50 ng, 100 ng, 500 ng, 1 μg, 10 μg, 50 μg, 100 μg, 500 μg, 1 mg, 10 mg, 100 mg, 500 mg, 1 g, 2 g, 3 g, 4 g, or 5 g of the one or more compounds.", "The methods and uses of the present invention may further comprise the step of harvesting a product from the reared animal with enhanced growth.", "The harvested product may be the body or part of the body of the animal.", "In that case, the harvesting process includes the step of slaughtering the animal and optionally preparing an animal carcass or part thereof as a product, such as a meat product.", "Accordingly, the harvested body or part of the body of then animal may be a non-food product, a food product, or a precursor of a food product.", "Carcasses and parts of carcasses may go through a process known as rendering to be made into human and non-human foodstuffs, fats, and other material that can be sold to make commercial products such as cosmetics, paint, cleaners, polishes, glue, soap and ink.", "Further such products that may be foodstuffs include but are not limited to blood, bone, including bone char, bone meal, etc., broths and stocks created with animal fat, bone, and/or connective tissue, carmine also known as cochineal (food dye), casein (found in milk and cheese), civet oil (food flavoring additive), gelatin, isinglass (which, may, for example be used in clarification of beer and wine), L-cysteine (which may for example used in the production of biscuits and bread), lard, meat (including fish, poultry, and game), and rennet (commonly used in the production of cheese).", "Meat and meat products may be of particular interest.", "In one embodiment of particular interest in the context of the present invention, the animal is a chicken, for example, a meat-type chicken such as broiler chicken, or an egg-laying chicken such as a pullet or hen, and the product is harvested from the reared animal.", "Most preferably, the animal is a meat-type chicken, such as broiler chicken, and the harvested product is a carcass or part of the carcass of the chicken.", "After slaughter to produce the carcass, it may or may not be further processed, such as to remove one or more items selected from the group consisting of feathers, offal, neck skin, head, legs, and other items, and may produce a whole dressed carcass ready for sale as a meat product, or ready to send onto further processing.", "In one embodiment the processed carcass may retain the neck or neck skin, or at least 50%, 60%, 70%, 80%, 90% or more thereof as determined either by length or by weight.", "The average weight of the neck or neck skin may be in the range of 15-25 g. Further processing may include performing a cut-up operation wherein the carcass is cut into individual parts, and may involve deboning (i.e.", "where the bones are removed from specific parts) to produce items like breast filets or other boneless products.", "In one exemplary embodiment, a process for the slaughter and/or processing of a chicken may include any one or more of the following methodological step: (i) birds arrive at processing plant, typically in plastic crates; (ii) blue light is used to calm the birds; (iii) birds are hung; (iv) birds enter a stun tank; (v) birds are slaughtered using a neck bleed, optionally with a delay stand for bleeding out the birds; (vi) birds skin and/or feathers are heated, for example with water, to loosen pores holding the feathers; (vii) feathers are removed, e.g.", "using rubber fingers; (viii) an inspection is conducted to remove any birds failing a quality control assessment; (ix) drill or other implement is used to create a hole in the carcass and remove anus; (x) removal of the intestines and other internal organs, typically via the previously-created hole; (xi) optionally, the production line splits for the production of whole chickens and chicken parts; (xii) chicken parts may be cut up using an automated process and through manual labor (workers slicing); optionally including the separate liver, kidney and/or hearts; (xiii) the whole chicken carcass and/or chicken parts may be directly labeled on the floor of the processing plant, ready for the grocery store (further optionally including pricing) so the product can go directly on the store shelf.", "It will be appreciated that alternative methods of stunning the bird are available, and can be substituted for the method indicated in the foregoing method and/or used more generally in accordance with the first aspect of the present invention.", "Exemplary alternative methods of stunning the bird include, for example, controlled atmosphere stunning, controlled atmosphere killing, Bi-phasic CO2, and controlled slow decompression.", "Controlled atmosphere stunning (otherwise known as gas stunning) can be applied to birds in transport crates, which may be conveyed through a tunnel or other chamber filled with increasing concentrations of carbon dioxide, inert gases (argon or nitrogen), or a mixture of these gases.", "The gas or gases induce unconsciousness, before slaughter.", "For example, at that point, the birds are hung on shackles, while insensible, and conveyed to the killing machine for slaughter.", "Controlled atmosphere killing (CAK) can be operated by exposing birds to lethal concentrations of gases long enough that they are actually killed, rather than stunned (to avoid the risk that birds regaining consciousness after exiting the gaseous atmosphere).", "For example, carbon dioxide depresses the central nervous systems directly and produces rapid unconsciousness.", "However, carbon dioxide is aversive to chickens (usually if levels are above 20%).", "Inhalation of the inert gases (e.g.", "argon and nitrogen) can also be used, when inhaled in high concentrations, to cause oxygen deprivation in the body, leading to death.", "Bi-phasic CO2 is a newer gas stunning method which uses carbon dioxide in two phases to kill poultry.", "The first phase containing up to 40% of carbon dioxide (only moderately aversive to chickens), renders the birds unconscious, the second phase follows with lethal carbon dioxide levels.", "Controlled slow decompression can include the use of a Low Atmospheric Pressure System (LAPS).", "Killing by LASP mimics the physiological effects of ascending to high altitudes by using controlled slow decompression, which allows the body of the bird to adjust to changes in pressure and thus lose consciousness (from a lack of oxygen) with minimal discomfort.", "Alternatively, the bird may not be stunned prior to slaughter, e.g.", "in the case of the production of a meat product in accordance with religious laws, such as Halal, Qurrbani/Udhia, and/or Shechita slaughter laws.", "The processing of the carcass may be conducted at adequately low refrigeration temperatures, such as around 1, 2, 3, 4 or 5° C. Accordingly, following the processing of the animal carcass and/or the production of parts thereof, the carcass or part thereof may be further processed to produce a value added product, and this may include one or more steps required to prepare a consumer-ready product, which may include the addition of any one or more of seasoning, breading, sauces, and marinating, as well as special packaging to meet market demands for convenient products.", "Additionally, or alternatively, the harvested product may, for example, be a by-product of the animal, such as milk, eggs, wool, hair, feathers, or litter or other feacal matter and can be collected from the animal without the need to slaughter the animal.", "Such harvested products may then be further processed and converted into other products.", "For example, in the context of milk, then further dairy products can be produced (such as butter, cheese, curd, yoghurt, whey, milk powder, sour cream, dips and other cultured dairy foods, frozen desserts such as ice cream cakes other frozen desserts made with dairy ingredients).", "In the context of eggs, then further products (in particular food products) containing or produced with the whole or part of the collected eggs can be produced.", "In the context of wool, hair or feathers, then it may, for example, be possible to produce fibers or fabrics, products containing wool, hair or feathers (such as, stuffed products), or products may be chemical or enzymatic processing of the wool, hair or feathers.", "For example, amino acids can be produced as a degradation product from wool, hair or feathers.", "Chicken litter can include a mixture of feces, wasted feeds, bedding materials, and feathers can be recycled or composted and then spread on arable land as a low cost organic fertilizer.", "Any and all steps within the entire process of animal rearing, animal harvesting, animal slaughter, carcass processes, animal product production, food production, wrapping, labelling, shipping, stocking and selling in accordance with the first aspect of the present invention may benefit from the application of a surface disinfection or coating in accordance with the third aspect of the present invention, as discussed further below.", "For example, areas for rearing animals in accordance with the first aspect of the present invention may contain one or more disinfected surfaces achieved using the methods, uses and compositions of the third aspect of the present invention.", "Containers for transporting animals in accordance with the practice of the first aspect of the present invention may contain one or more disinfected surfaces achieved using the methods, uses and compositions of the third aspect of the present invention.", "Apparatus used in the slaughter of animals in accordance with the practice of the first aspect of the present invention may contain one or more disinfected surfaces achieved using the methods, uses and compositions of the third aspect of the present invention.", "Apparatus used in the processing and/or labelling of an animal carcass, or a part thereof, in accordance with the practice of the first aspect of the present invention may possess one or more disinfected surfaces achieved using the methods, uses and compositions of the third aspect of the present invention.", "The animal product, including a carcass, a meat product, or any other animal product as produced in accordance with the first aspect of the present invention may be disinfected using the methods, uses and compositions of the third aspect of the present invention.", "Packing, containers and/or wrapping for containing an animal product, including a carcass, a meat product, or any other animal product as produced in accordance with the first aspect of the present invention may be disinfected using the methods, uses and compositions of the third aspect of the present invention.", "These combinations of the approaches set forth by the first and third aspects of the present invention all form optional embodiments of the first aspect of the present invention.", "The present invention also provides products produced by, and/or harvested from, animals treated in accordance with the first aspect of the present invention, including any and all products discussed above, and downstream products including or produced therefrom.", "For example, the present application provides a meat or meat product produced in accordance with the present invention.", "For example, it can provide a carcass or part thereof that is of a greater weight than a standard carcass or part thereof, or is from an animal that is younger than a control.", "Additionally, or alternatively, carcass or part thereof, or any other product obtained from the animal may have a reduced level of microbial (such as bacterial, including Campylobacter) infection or colonization and/or a reduced incidence of biofilms therein, compared to a control.", "It will be appreciated that the foregoing methods and uses for enhancing the growth of an animal may also be applied to humans, for example to increase the growth of humans (such as an aid to developing body mass) and/or improve the efficiency or FCR with which humans digest food.", "This could, for example, have applications for military personnel in helping to reduce the burden of carrying food and/or assist in the instance of food shortages by increasing the dietary benefit of the available food.", "B. Potentiating the Effect of Antibiotics and Other Antimicrobial Agents, and Addressing Antibiotic Resistance It has been discovered that the compounds having the structure of Formula A or B, or other compounds of the present invention as described further in section III.A of this application, are particularly useful in treating or preventing infection by antibiotic-resistant microorganisms.", "The compounds may be administered in order to cause microorganisms to lose their resistance to antibiotics.", "In Example 9, it was shown that a kanamycin-resistant strain of E. coli failed to grow when it was treated with Fe-QA and kanamycin.", "Yet administration of Fe-QA alone had no impact on the growth of the strain.", "In Example 10, it was shown that the growth of another kanamycin-resistant bacterial strain, Campylobacter, was retarded when it was treated with Fe-QA and kanamycin.", "In Example 14, it was shown that the growth of an antibiotic-resistant clinical isolate of Pseudomonas was also retarded when treated with Fe-QA (also known as FeQ) and kanamycin.", "The effect therefore is not limited just to the bacterium, E. coli.", "In Example 12, it has also been shown that a wild type strain of Enteropathogenic E. coli (EPEC) resistant to gentamicin loses its resistance when treated with a combination of Fe-QA and gentamicin.", "The example demonstrates that the effect is not limited to kanamycin, but is seen with other antibiotics.", "Furthermore, the effect is not limited to the compound, Fe-QA, but is also seen with the other compounds.", "In Example 11, it has been shown that the same wild type strain of Enteropathogenic E. coli (EPEC) resistant to gentamicin also loses its resistance when treated with a combination of Fe-Tyr and gentamicin.", "Thus the compounds are capable of causing antibiotic-resistant bacteria to lose their resistance, and therefore administering the compounds and antibiotics can be used to treat antibiotic resistant microorganisms (or prevent infection by these microorganisms).", "Accordingly, a second aspect of the present invention is based on the surprising finding that compounds having the structure of Formula A or B, or other compounds of the present invention as described further in section III.A of this application, can be used to increase the sensitivity of microorganism to antimicrobial agents, to potentiate the effect of antibiotics and other antimicrobial agents, and to address antimicrobial and antibiotic resistance.", "In a further preferred option of the second aspect of the present invention the one or more compounds are selected from the group consisting of a complex of an amino acid with Fe III, and a complex of an α-hydroxyacid with Fe III, or salts and/or hydrates thereof.", "In particularly preferred options of the second aspect of the present invention, the one or more compounds may, or may not, be selected from any one or more of the group consisting of a complex of quinic acid with Fe III (such as a complex having the structure of Formula IX), a complex of L-tyrosine with Fe III (such as a complex having the structure of Formula VIII), a complex of L-DOPA with Fe III (such as a complex having the structure of Formula VII), and a complex of L-phenylalanine with Fe III.", "Accordingly, in one embodiment of the second aspect of the invention, a complex of L-tyrosine with Fe III (such as a complex having the structure of Formula VIII) is particularly preferred.", "Optionally, the one or more compounds is not a complex of quinic acid with Fe III (such as a complex having the structure of Formula IX).", "In a particularly preferred embodiment, the compounds having the structure of Formula A or B, or other compounds of the present invention as described further in section III.A of this application may be used in combination with antimicrobial agents to treat or prevent infection by antibiotic resistant bacteria including Streptococcus pneumoniae, Campylobacter, Neisseria gonorrhoeae, Salmonella (including drug-resistant non-typhoidal Salmonella and drug-resistant Salmonella serotype typhi), Methicillin-resistant Staphylococcus aureus (MRSA), Shigella, Vancomycin-resistant Enterococcus (VRE), Vancomycin-resistant Staphylococcus aureus (VRSA), Erythromycin-resistant Group A Streptococcus, Clindamycin-resistant Group B Streptococcus, Carbapenem-resistant Enterobacteriaceae (CRE), drug-resistant tuberculosis, Extended spectrum Enterobacteriaceae (ESBL), multidrug-resistant Acinetobacter (including MRAB), Clostridium difficile, Enteropathogenic E. coli (EPEC), Pseudomonas aeruginosa, and Uropathogenic E. coli (UPEC).", "In another preferred embodiment.", "In another embodiment, the compounds may be used in combination with antimicrobial agents to treat or prevent infection by antibiotic resistant bacteria including S. epidermidis, E. faecalis, E. coli, S. aureus, Enteropathogenic Escherichia coli (EPEC), Uropathogenic Escherichia coli (UPEC), Pseudomonas, Streptococcus anginosus, Salmonella, including Salmonella Enteritidis and Salmonella Typhimurium, Mycoplasma, Eimeria, Enterococci, Brachyspira, and Clostridium perfringen.", "In a preferred embodiment, the compounds and antimicrobial agents may be administered as a pharmaceutical composition or feed additive.", "Antibiotic-resistant microorganisms (and other microorganisms resistant to other forms of anti-microbial agent) may be treated with the one or more compounds and one or more antibiotics or other anti-microbial agents separately, sequentially or simultaneously.", "The one or more compounds are preferably administered at the same time as the one or more antibiotics or other anti-microbial agents, or preferably such that the compounds and antibiotic(s) are present at the same time.", "(The compounds and the antibiotics/anti-microbial agents may therefore also be administered sequentially.)", "As described previously, the compounds may also be formed in vivo.", "In this instance, the precursors may be administered with the antibiotics or other anti-microbial agents.", "For example, the antibiotics or other anti-microbial agents could be administered with ferrous sulfate and tyrosine (which form Fe-Tyr in vivo) or ferrous sulfate and L-DOPA (which form Fe-DOPA in vivo), or ferrous sulfate and L-phenylalanine (which form Fe-Phe in vivo).", "The combinations of the compounds and antibiotic(s) or other anti-microbial agent(s) may be used to treat many infections, including, but not limited to the following infections: acute bacterial skin infections, hospital-acquired bacterial pneumonia, ventilator-acquired bacterial pneumonia, urinary tract infections, abdominal infections, kidney infections, gonorrhea, osteomyelitis, lung infections, and respiratory tract infections.", "The compounds may also be used in combination with antibiotics or other anti-microbial agents to allow smaller doses of antibiotic or other anti-microbial agents to be used to treat not only antibiotic-resistant microorganisms (and/or other microorganisms resistant to other forms of anti-microbial agent), but also for the treatment of microorganisms that are not resistant to antibiotics or other anti-microbial agents.", "In other words, the compounds may allow smaller doses of antibiotic or other anti-microbial agent to be used to treat or prevent infections, and could also be administered to patients and animals prophylactically.", "For example, the compounds could be administered to poultry prophylactically so that a lower dose of antibiotic and/or other anti-microbial agent was required to treat the birds in the event they become infected.", "Accordingly, a second aspect of the present invention provides a method for the treatment or prophylaxis of a microbial infection or colonization in a patient or animal, the method comprising administering to the patient or animal a product selected from the group consisting of a pharmaceutical or veterinary product, a medical device or a dietary product, wherein the product comprises one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, and preferably wherein the pharmaceutical or veterinary product, medical device or dietary product is administered to the patient or animal separately, simultaneously, or sequentially with the administration of one or more antimicrobials and/or antibiotics.", "In other words, the second aspect of the present invention provides a pharmaceutical or veterinary product, a medical device or a dietary product, wherein the product comprises one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, for use in a method of treatment or prophylaxis of a microbial infection or colonization in a patient or animal, preferably wherein, in use, the pharmaceutical or veterinary product, medical device or dietary product is administered to the patient or animal separately, simultaneously, or sequentially with the administration of one or more antimicrobials and/or antibiotics.", "Likewise, the second aspect of the present invention also provides one or more antimicrobials and/or antibiotics, for use in a method of treatment or prophylaxis of a microbial infection or colonization in a patient or animal, preferably wherein, in use, the pharmaceutical or veterinary product, medical device or dietary product is administered to the patient or animal separately, simultaneously, or sequentially with the administration of a pharmaceutical or veterinary product, a medical device or a dietary product, wherein the product comprises one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below.", "The microbial infection or colonization in a patient or animal may, for example, be pathogenic or non-pathogenic microbes.", "Non-pathogenic microbes can, for example, cause colonization of a host without causing or producing any disease or disorder of the host.", "The microbial infection or colonization addressed by the second aspect of the present invention may be prokaryotic.", "Examples of prokaryotic microbes include bacteria and archaea.", "The microbial infection or colonization addressed by the second aspect of the present invention may be eukaryotic.", "Examples of eukaryotic microbes include protists (such as algae, and slime-molds), fungi, multicellular micro-animals and plants including green algaes.", "One class of microbes of particular interest for the application of the second aspect of the present invention is bacteria, including pathogenic and non-pathogenic bacteria.", "By way of various non-limiting examples, bacteria of particular interest for the application of the second aspect of the present invention include gram positive bacteria, gram negative bacteria, biofilm-forming bacteria, extracellular bacteria, intracellular bacteria (including facultative and obligate intracellular bacteria), aerobic bacteria, and anaerobic bacteria.", "Some bacterial genera of interest, without limitation, include Bacillus, Bartonella, Bordetella, Borrelia, Brucella, Campylobacter, Chlamydia and Chlamydophila, Clostridium, Corynebacterium, Enterococcus, Escherichia, Francisella, Haemophilus, Helicobacter, Legionella, Leptospira, Listeria, Mycobacterium, Mycoplasma, Neisseria, Pseudomonas, Rickettsia, Salmonella, Shigella, Staphylococcus, Streptococcus, Treponema, Ureaplasma, Vibrio, and Yersinia.", "Some bacterial species of interest, without limitation, include Bacillus anthracis, Bacillus cereus, Bartonella henselae, Bartonella quintana, Bordetella pertussis, Borrelia burgdorferi, Borrelia garinii, Borrelia afzelii, Borrelia recurrentis, Brucella abortus, Brucella canis, Brucella melitensis, Brucella suis, Campylobacter jejuni, Chlamydia pneumonia, Chlamydia trachomatis, Chlamydophila psittaci, Clostridium botulinum, Clostridium difficile, Clostridium perfringens, Clostridium tetani, Corynebacterium diphtheria, Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Francisella tularensis, Haemophilus influenza, Helicobacter pylori, Legionella pneumophila, Leptospira interrogans, Leptospira santarosai, Leptospira weilii, Leptospira noguchii, Listeria monocytogenes, Mycobacterium leprae, Mycobacterium tuberculosis, Mycobacterium ulcerans, Mycoplasma pneumonia, Neisseria gonorrhoeae, Neisseria meningitides, Pseudomonas aeruginosa, Rickettsia rickettsia, Salmonella typhi, Salmonella typhimurium, Shigella sonnei, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Streptococcus agalactiae, Streptococcus pneumonia, Streptococcus pyogenes, Treponema pallidum, Ureaplasma urealyticum, Vibrio cholera, Yersinia pestis, Yersinia enterocolitica, Yersinia pseudotuberculosis.", "The treatment or prophylaxis of the second aspect of the present invention may be directed to one or more microorganism that have resistance or increased tolerance to one or more antimicrobial agents.", "For example, the one or microorganisms may be, or include, one or more antibiotic-resistant bacteria.", "As such, in the embodiment in which the second aspect of the present invention is performed by administration separately, simultaneously, or sequentially with the administration of one or more antimicrobials and/or antibiotics, then some or all of the one or more antimicrobials and/or antibiotics may be antimicrobials and/or antibiotics to which the microorganisms to be combatted are resistant.", "To put it another way, typically the microorganisms to be combatted may be those wherein, in the absence of the product comprising one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, the one or more microorganisms is/are resistant to the one or more antimicrobials and/or antibiotics administered to the patient or animal.", "Antimicrobial resistance can include the meaning of resistance of a microorganism to an antimicrobial drug that was originally effective for treatment of infections caused by it.", "Resistant microorganisms are able to withstand attack by antimicrobial drugs, such as antibacterial drugs (e.g.", "antibiotics), antifungals, antivirals, and antimalarials, so that standard treatments become ineffective and infections persist, increasing the risk of spread to others.", "The evolution of resistant strains is a natural phenomenon that occurs when microorganisms replicate themselves erroneously or when resistant traits are exchanged between them.", "The use and misuse of antimicrobial drugs accelerates the emergence of drug-resistant strains.", "Poor infection control practices, inadequate sanitary conditions and inappropriate food-handling encourage the further spread of antimicrobial resistance.", "In one embodiment of the second aspect of the present invention, the microorganism is an antibiotic-resistant microorganism selected from the group consisting of a gram positive bacterium, a gram negative bacterium, a biofilm-forming bacterium, Streptococcus pneumoniae, Campylobacter, Neisseria gonorrhoeae, Salmonella (including drug-resistant non-typhoidal Salmonella and drug-resistant Salmonella serotype typhi), Methicillin-resistant Staphylococcus aureus (MRSA), Shigella, Vancomycin-resistant Enterococcus (VRE), Vancomycin-resistant Staphylococcus aureus (VRSA), Erythromycin-resistant Group A Streptococcus, Clindamycin-resistant Group B Streptococcus, Carbapenem-resistant Enterobacteriaceae (CRE), drug-resistant tuberculosis, Extended spectrum Enterobacteriaceae (ESBL), multidrug-resistant Acinetobacter (including MRAB), Clostridium difficile, Enteropathogenic E. coli (EPEC), Pseudomonas aeruginosa, H. pylori, Streptococcus anginosus and Uropathogenic E. coli (UPEC).", "However, the practice of the second aspect of the invention is not limited to the treatment or prophylaxis of resistant microorganisms.", "The second aspect of the present invention can also be used to increase the sensitivity of non-resistant microorganisms to antimicrobial agents, and thereby provide for a treatment that uses lower dosages of antimicrobial agents, and/or shorter treatment durations with antimicrobial agents, and/or more effective treatment outcomes with antimicrobial agents.", "Accordingly, in a further embodiment of the second aspect of the present invention, the method, or the product for use, is for potentiating the antimicrobial (including antibiotic) effect of the separately, simultaneously, or sequentially administered one or more antimicrobial agents (including one or more antibiotics).", "For example, in a further embodiment, the amount of the separately, simultaneously, or sequentially administered one or more antimicrobial agents (including one or more antibiotics) may be less than a therapeutically effective or therapeutically optimal dose of the one or more antimicrobial agents (including one or more antibiotics) when administered to the patient or animal that is not in receipt of the product.", "In another embodiment, the amount of the separately, simultaneously, or sequentially administered one or more antimicrobial agents (including one or more antibiotics) may be 5%, 10%, 15%, 20%, 30%, 40%, 50%, 60%, 70%, 80% or more, less than a therapeutically effective or therapeutically optimal dose of the one or more antibiotics when administered to the patient or animal that is not in receipt of the product.", "In another embodiment, the treatment duration of the patient receiving the treatment or prophylaxis of the second embodiment may be 5%, 10%, 15%, 20%, 30%, 40%, 50%, 60%, 70%, 80% or more, less than the treatment duration required when the patient or animal is not in receipt of the product.", "Preferably, the subject to be treated in accordance with any embodiment of the second aspect of the present invention, is a human patient.", "The human may be a male.", "Alternatively the human may be a female.", "The human may be aged up to, or greater than, 1 month, 2, months, 3 months, 4 months, 5 months, 6 months, 1 year, 2 years, 3 years, 4 years, 5 years, 6 years, 7 years, 8 years 9 years, 10 years, 15 years 20 years, 30, years, 40 years, 50 years, 60 years, 70 years, 80 years, 90 years, 100 years or more.", "Alternatively, subject to be treated in accordance with any embodiment of the second aspect of the present invention, may be an animal.", "Without limitation, animals for treatment or prophylaxis according to the second aspect of the present invention may be selected from the group consisting of domestic, wild and farmed animal, including mammals, marine animals, amphibians, birds, reptiles, insects and other invertebrates.", "Without limitation, exemplary animals for treatment or prophylaxis include poultry, such as a chicken, turkey, geese, quail, pheasants, or ducks; livestock, such as cattle, sheep, goats or swine, alpaca, banteng, bison, camel, cat, deer, dog, donkey, gayal, guinea pig, horse, llama, mule, rabbit, reindeer, water buffalo, yak; zoo animals; captive animals; game animals; marine or aquatic animals such as fish (include freshwater and saltwater fish, farmed fish, and ornamental fish) and shellfish including but not limited to oysters, mussels, clams, shrimps, prawns, lobsters, crayfish, crabs, cuttlefish, octopus, and squid; domestic animals, such as cat or dog, a rodent (mice, rats, guinea pigs, hamsters), horse.", "The one or more antimicrobial agents used and/or referred to in the second aspect of the present invention include those listed and discussed in section III.B of this application, below.", "In one embodiment, at least one, or all, of the one or more antimicrobial agents is/are an antibiotic.", "The one or more antibiotics may, for example, be selected from the group consisting of aminoglycosides, ansaycins, carbapenems, cephalosporins, glycopeptides, lincosamides, lipopeptides, macrolides, monobactams, nitrofurans, oxazolidinones, penicillins, polypeptides, quinolones/fluoroquinolone, sulfonamides, tetracyclines, clofazimine, dapsone, capreomycin, cycloserine, ethambutol, ethionamide, isoniazid, pyrazinamide, rifampicin (rifampin), rifabutin, rifapentine, streptomycin, arsphenamine, chloramphenicol, fosfomycin, fusidic acid, metronidazole, mupirocin, platensimycin, quinupristin/dalfopristin, thiamphenicol, tigecycline, tinidazole, and trimethoprim; and combinations thereof.", "More specific antibiotics suitable for use in accordance with the second aspect of the present invention include those listed and discussed in section III.B of this application, below.", "In one embodiment of the second aspect of the present invention, the product comprising the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below is selected from the group consisting of a pharmaceutical or veterinary product.", "In one embodiment, it is a pharmaceutical product suitable for use with humans.", "In another embodiment, it is veterinary product suitable for use with animals, including but not limited to one or more animals selected from the group consisting of domestic, wild and farmed animal, including mammals, marine animals, amphibians, birds, reptiles, insects and other invertebrates.", "Without limitation, exemplary animals for treatment or prophylaxis include poultry, such as a chicken, turkey, geese, quail, pheasant, or ducks; livestock, such as cattle, sheep, goats or swine, alpaca, banteng, bison, camel, cat, deer, dog, donkey, gayal, guinea pig, horse, llama, mule, rabbit, reindeer, water buffalo, yak; zoo animals, captive animals, game animals; marine or aquatic animals such as fish (include freshwater and saltwater fish, farmed fish, and ornamental fish) and shellfish including but not limited to oysters, mussels, clams, shrimps, prawns, lobsters, crayfish, crabs, cuttlefish, octopus, and squid; domestic animals, such as cat or dog, a rodent (mice, rats, guinea pigs, hamsters), horse.", "In a preferred embodiment, the animal is a chicken, for example, a meat-type chicken such as broiler chicken, or an egg-laying chicken such as a pullet or hen, or a breeder chicken.", "The pharmaceutical or veterinary product may or may not additionally include the one or more antimicrobial agents (in the embodiment that it does not, then in accordance with the second aspect of the present invention, the product and microbial agent are intended to be administered to the subject in separate compositions, either separately, simultaneously or sequentially).", "The pharmaceutical or veterinary product may include one or more excipients, such as discussed in section III.C of this application, below.", "The pharmaceutical or veterinary product may be presented as a parenteral formulation, such as discussed below in section III.C.1 of this application, including a controlled release formulation, such as discussed below in section III.C.1(a) of this application, and injectable or implantable formulation, such as discussed below in section III.C.1(b) of this application.", "The pharmaceutical or veterinary product may be presented as a enteral formulation, such as discussed below in section III.C.2 of this application, including a controlled release enteral formulation, such as discussed below in section III.C.2(a) of this application, with further reference to extended release dosage forms and delayed release dosage forms as discussed therein.", "The pharmaceutical or veterinary product may be presented as a topical formulation, such as discussed below in section III.C.3 of this application, including as an emulsion, lotion, cream, ointment, gel, or foam as discussed in parts (a), (b), (c), (d) (e) and (f) respectively below in section III.C.3 of this application.", "In another embodiment, the product comprising the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below is a medical device.", "The device may or may not additionally include the one or more antimicrobial agents (in the embodiment that it does not, then in accordance with the second aspect of the present invention, the device and microbial agent are intended to be administered to the subject in separate compositions, either separately, simultaneously or sequentially).", "Medical devices that can comprise the one or more compounds as defined in section III.A of this application can include, without limitation, wound dressings or medical implants.", "Further examples include tubing and other surface medical devices, such as urinary catheter, stents, mucous extraction catheter, suction catheter, umbilical cannula, contact lenses, intrauterine devices, intravaginal and intraintestinal devices, endotracheal tubes, bronchoscopes, dental prostheses and orthodontic devices, surgical instruments, dental instruments, tubing, dental water lines, dental drain tubes, fabrics, paper, indicator strips (e.g., paper indicator strips or plastic indicator strips), adhesives (e.g., hydrogel adhesives, hot-melt adhesives, or solvent-based adhesives), bandages, tissue dressings or healing devices and occlusive patches, and any other surface devices used in the medical field.", "Devices may include electrodes, external prostheses, fixation tapes, compression bandages, and monitors of various types.", "Medical devices also include any device that may be placed at the insertion or implantation site such as the skin near the insertion or implantation site, and which include at least one surface which is susceptible to colonization by biofilm embedded microorganisms.", "In one specific embodiment, a composition is integrated into an adhesive, such as tape, thereby providing an adhesive, which can present and/or deliver the one or more compounds on at least one surface of the adhesive.", "In a particularly preferred embodiment the following devices may comprise, include and/or be coated with the compounds: catheters, including central venous catheters, urinary catheters, dialysis catheters, and indwelling catheters (for example, catheters for hemodialysis and for administration of chemotherapeutic agents), cardiac implants including mechanical heart valves, stents, ventricular assist devices, pacemakers, cardiac rhythm management (CRM) devices, cardiac resynchronization therapy devices (CRTs), and implantable cardioverter defibrillators (JCDs), synthetic vascular grafts, arteriovascular shunts, cerebral spinal fluid shunts, cochlear devices, prosthetic joints, orthopedic implants, internal fixation devices, bone cements, percutaneous sutures, surgical mesh and surgical patches including hernia repair meshes and patches, breast reconstruction meshes and patches, meshes and patches for breast and face lifts, slings, and meshes and patches for pelvic floor reconstruction, tracheal and ventilator tubing, wound dressings, biological implants (including allografts, xenografts and autografts), penile implants, intrauterine devices, endotracheal tubes, and contact lenses.", "In another embodiment, the product comprising the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below is a dietary product.", "The dietary product may or may not additionally include the one or more antimicrobial agents (in the embodiment that it does not, then in accordance with the second aspect of the present invention, the dietary product and microbial agent are intended to be administered to the subject in separate compositions, either separately, simultaneously or sequentially).", "Dietary products can include, for example, food stuffs, dietary supplements, drinks and any other compositions taken orally, which incorporate the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below.", "The one or more compounds are selected from the group consisting of a complex of an amino acid with Fe III, and a complex of an α-hydroxyacid with Fe III, or salts and/or hydrates thereof.", "The one or more compounds may, or may not, be selected from any one or more of the group consisting of a complex of quinic acid with Fe III (such as a complex having the structure of Formula IX), a complex of L-tyrosine with Fe III (such as a complex having the structure of Formula VIII), a complex of L-DOPA with Fe III (such as a complex having the structure of Formula VII), and a complex of L-phenylalanine with Fe III.", "Accordingly, in one embodiment, a complex of L-tyrosine with Fe III (such as a complex having the structure of Formula VIII) is particularly preferred.", "Optionally, the one or more compounds is not a complex of quinic acid with Fe III (such as a complex having the structure of Formula IX).", "A complex of quinic acid with Fe III (Fe-QA, also denoted FeQ), such as defined by Formula IX, can be used with any one or more of the foregoing antibiotics or other antimicrobials, either formulated together in the same composition for administration or presented in separate compositions for use separately, simultaneously or sequentially.", "A complex of quinic acid with Fe III (Fe-QA, also denoted FeQ), such as defined by Formula IX, can be used with any one or more of the foregoing antibiotics or antimicrobials, either formulated together in the same composition for administration or presented in separate compositions for use separately, simultaneously or sequentially.", "A complex of L-tyrosine with Fe III (Fe-Tyr), such as defined by Formula VIII, can be used with any one or more of the foregoing antibiotics or antimicrobials, either formulated together in the same composition for administration or presented in separate compositions for use separately, simultaneously or sequentially.", "A complex of L-DOPA with Fe III (3,4 dihydrophenylalanine) (Fe-DOPA), such as defined by Formula VII, can be with any one or more of the foregoing antibiotics or antibiotics, either formulated together in the same composition for administration or presented in separate compositions for use separately, simultaneously or sequentially.", "A complex of L-phenylalanine with Fe III (Fe-Phe), can be used with any one or more of the foregoing antibiotics or antibiotics, either formulated together in the same composition for administration or presented in separate compositions for use separately, simultaneously or sequentially.", "In one embodiment in which the product selected from the group consisting of a pharmaceutical or veterinary product, a medical device or a dietary product comprising the combination of one or more compounds having the structure having the structure of Formula A or B, or other compounds as described further in section III.A of this application below, and one or more antibiotics or other antimicrobial agents, then optionally the amount (in weight, or moles) and/or concentration of the one or more antibiotics and/or other antimicrobial agents in the product is less than (e.g.", "a reduction of up to, or at least, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 15%, 20%, 35%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more) in comparison to a therapeutically effective or therapeutically optimal amount or concentration of the one or more antibiotics and/or other antimicrobial agents when administered to the patient or animal that is not in receipt of the product.", "The product may be presented in a unit dosage formulation, and optionally the unit dosage formulation may include the one or more antibiotics and/or other antimicrobial agents in an amount (in weight, or moles) or and/or concentration that is less than (e.g.", "a reduction of up to, or at least, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 15%, 20%, 35%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more) in comparison a therapeutically effective or therapeutically optimal dose of the one or more antibiotics when administered to the patient or animal that is not in receipt of the product.", "Also provided is a product per se, such as a pharmaceutical or veterinary product, a medical device or a dietary product, that is suitable for use in accordance with the foregoing methods and uses of the second aspect of the present invention.", "The product comprises one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, optionally in combination with one or more antibiotics or other antimicrobial agents as discussed herein in respect of the second aspect of the present invention.", "As discussed above, in the option in which the product comprises one or more antibiotics or other antimicrobial agents, then they may be included in an amount, concentration and or with a release profile that is ordinarily sub-therapeutic or sub-optimally therapeutic for the treatment or prophylaxis of a microbial infection or colonization.", "Also provided herein, is a method for the sensitization, and/or for the reduction in the tolerance, of one or more microorganisms to a selected antimicrobial agent, the method comprising exposing the one or more microorganisms to one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below.", "To put it another way, the second aspect of the present invention also provides for the use of one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below to increase the sensitivity and/or reduce the tolerance, of one or more microorganisms to a selected antimicrobial agent.", "The microorganisms may, or may not, be microorganisms that are resistant to the selected antimicrobial agent.", "Thus, in one option, the in vivo and/or in vitro growth of the one or more microorganisms may usually be unaffected by the selected antimicrobial agent (either at all, or at a selected concentration) in the absence of the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, whereas exposure to the one or more compounds can cause the in vivo and/or in vitro growth of the one or more microorganisms to be reduced (e.g.", "by 1%, 2%, 3%, 4%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99% or substantially 100%) by exposure to the selected antimicrobial agent (either at all, or at the selected concentration).", "In that context, a “selected concentration” includes concentrations that are pharmaceutically and medically acceptable for use with patients and/or animals, and lower concentrations such as 1%, 2%, 3%, 4%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, or 99% lower, which may or may not be sub-therapeutic.", "In another option, it may already be possible to reduce the in vivo and/or in vitro growth of the one or more microorganisms by exposure to the antimicrobial agent (either at all, or at a selected concentration) in the absence of the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, whereas exposure to the one or more compounds can cause an increase in sensitivity and/or reduction in tolerance to the antimicrobial agent such that the in vivo and/or in vitro growth of the one or more microorganisms is further reduced (e.g.", "by 1%, 2%, 3%, 4%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99% or substantially 100%) by the antimicrobial agent and/or an equivalent level of reduction of growth can be achieved with a lower concentration or amount of the antimicrobial agent (e.g.", "using an amount (in weight) or concentration that is reduced by 1%, 2%, 3%, 4%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99% or substantially 100%) and/or the period of treatment may be shortened, e.g.", "by 1, 2, 3, 4, 5, 6, 7 or more days.", "A further embodiment provides a method for the preparation of a product per se, such as a pharmaceutical or veterinary product, a medical device or a dietary product, that is suitable for use in accordance with the foregoing methods and uses of the second aspect of the present invention.", "The method may include the step of mixing the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below without one or more further components of the product, and thereby forming the product.", "The method may include forming the product (optionally without the one or more compounds), and then spraying or otherwise applying the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, to the product.", "The method may include forming the product (optionally without the one or more compounds), and then coating the product with the one or more compounds having the structure of Formula A or B, or other compounds of the invention as described further in section III.A of this application below, for example, as described further below in the context of coatings.", "The one or more compounds having the structure of Formula A or B, or other compounds as described further in section III.A of this application below (“Component 1”) may be administered simultaneously, separately or sequentially with the one or more antibiotics and/or other anti-microbial agents (“Component 2”).", "In the context of simultaneous administration, Components 1 and 2 may be present in the same product for administration to the patient or animal.", "Alternatively, Components 1 and 2 may be present in separate products which are administered at the same time, although this may be via the same of different routes.", "For example, both of Component 1 and 2 may be administered, in separate products but at the same time, through an enteral route.", "In another embodiment, Component 1 may be administered by an enteral route, and Component 2 may be administered at the same time by a parenteral route.", "In another embodiment, Component 1 may be administered by a parenteral route, and Component 2 may be administered at the same time by an enteral route.", "In another embodiment, both of Component 1 and 2 may be administered, in separate products but at the same time, through a parenteral route.", "In the context of separate and/or sequential administration, Components 1 and 2 are administered to the patient at different times.", "Component 1 may be administered before Component 2, or Component 2 may be administered before Component 1.Preferably, the period of time between the administration of Components 1 and 2 is less than the time taken by the subject to clear an effective amount of the first-administered component, such that effective amounts of Components 1 and 2 will be present in the subject simultaneously.", "However, this may not be essential.", "In any case, the time taken by the subject to clear an effective amount of the first-administered component will vary dependent on the nature of the component, the route of administration and the administered form which may, for example, be a slow, delayed or extended release formulation, product or device.", "The administration of Components 1 and 2 (in either order) may be temporally separated by up to, about, or at least, 10 seconds, 20 seconds, 30 seconds, 40 seconds, 50 seconds, 1 minute, 5 minutes 10 minutes, 20 minutes, 30 minutes 40 minutes 50 minutes 1 hour, 2 hours, 3 hours, 4 hours 5 hours, 6 hours, 7 hours 8 hours, 9 hours, 10 hours, 12 hours, 14 hours, 16 hours, 18 hours, 20 hours 22 hours 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 1 week, 2 weeks, 3 weeks, 1 month or more.", "Sequential administration includes the meaning of repeated and alternating administrations of Components 1 and 2 (in either order), in which the administration of either or both components may be repeated any number of times, such as twice, three times, four times, five times, 10 times, 20 times, 30 times or more.", "Repeated administration of either, or both components, whether administered simultaneously, separately or sequentially, may occur as often as is therapeutically necessary, and can include continuous administration (e.g.", "by intravenous infusion), of administration up to, about, or at least, every 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16,17, 18, 19, 20, 21, 22, 24 or 24 hours, every 1, 2, 3, 4, 5, 6, 7 days, or every 1, 2, 3, 4 or more weeks, throughout the period of treatment.", "The period of treatment in accordance with the second aspect of the present invention is typically selected to achieve a therapeutically or prophylactically effective outcome, and will be judged accordingly, by the skilled professional.", "Example of some suitable periods for treatment can include 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 days, about 1, 2, 3, or 4 weeks, or longer.", "C. Inhibition of Formation, and Treatment of Preformed, Biofilms A third aspect of the present invention is based on the surprising finding that compounds having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application, have a broad range of action in treating and dispersing pre-existing biofilms, and inhibiting the development of biofilms, created by a wide range of bacterial and other microbial sources, and that this action is effective in a diverse array of environments.", "Accordingly, a third aspect of the present invention provides a method of inhibiting biofilm buildup, and/or disrupting a pre-existing biofilm, in or on a subject or article in need thereof, the method comprising administering to the subject or article an effective amount of one or more compounds having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application.", "Put another way, the third aspect of the present invention provides for the use of one or more compounds having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application for inhibiting biofilm buildup, and/or disrupting a pre-existing biofilm, in or on a subject or article in need thereof.", "In one embodiment, the one or more compounds having the structure of Formula A or a salt and/or hydrate thereof, or a functional variant thereof, for use in accordance with the third aspect of the present invention are selected from the group consisting of a complex of an amino acid or an α-hydroxy acid with Fe III, such as a complex of quinic acid with Fe III, a complex of L-tyrosine with Fe III, a complex of L-DOPA with Fe III, a complex of L-phenylalanine with Fe III, the compounds represented by Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, Formula IX, Formula X, Formula XI, Formula XII, Formula XIII, Formulas XIV, a compound selected from the group consisting of a compound that binds to major outer membrane proteins (MOMPs) or FlaA of Campylobacter, a synthetic human histo-blood group antigen, a mimetic of human histo-blood group antigen or a synthetic sugar.", "Particularly preferred compounds may, or may not, include Fe-QA, Fe-Tyr, and/or Fe-DOPA.", "1.Organisms to be Treated, Inhibited, or Killed “Biofilm” as used herein refers any group of microorganisms in which cells stick to each other on a surface.", "Formation of a biofilm begins with the attachment of free-floating microorganisms to a surface.", "These first colonists adhere to the surface initially through weak, reversible adhesion via van der Waals forces.", "If the colonists are not immediately separated from the surface, they can anchor themselves more permanently using cell adhesion structures such as pili.", "Some species are not able to attach to a surface on their own but are sometimes able to anchor themselves to the matrix or directly to earlier colonists.", "It is during this colonization that the cells are able to communicate via quorum sensing.", "Once colonization has begun, the biofilm grows through a combination of cell division and recruitment.", "Polysaccharide matrices typically enclose bacterial biofilms.", "The final stage of biofilm formation is known as dispersion, and is the stage in which the biofilm is established and may only change in shape and size.", "In one embodiment, a biofilm may comprise, consist essentially of, or consist of, microbial cells growing in a biofilm that are physiologically distinct from planktonic cells of the same organism, which, by contrast, are single-cells.", "Optionally, a biofilm may comprise, consist essentially of, or consist of, one species or strain of bacterial cell.", "In an alternative option, a biofilm may comprise, consist essentially of, or consist of, more than one species or strains of bacterial cell, such as up to at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 30, 40, 50, 60 70, 80, 90, 100, 150, 200, 250, 300, 350, 400, 450, 500, 600, 700, 800, 900, 1000 or more different species or strains of bacterial cell.", "The bacterial species or strains in biofilms can include bacteria selected from one or more of gram negative, gram positive, aerobic and anaerobic bacteria and/or archaea.", "Accordingly, compositions and methods for inhibiting, reducing, or removing biofilm forming bacteria and bacterial infections are provided by the third aspect of the present invention.", "In accordance with some embodiments of the third aspect of the present invention, the biofilm forming bacteria to be inhibited, reduced, removed, or treated may be gram-negative and/or gram-positive bacteria, such as Pseudomonas aeruginosa, Campylobacter jejuni, Helicobacter pylori, Escherichia coli, Enteropathogenic Escherichia coli (EPEC), Uropathogenic Escherichia coli (UPEC), Staphylococcus epidermidis, Staphylococcus aureus, and Enterococcus faecalis.", "The following are representative organisms that can be killed or growth inhibited, or their ability to produce or maintain biofilms degraded, reduced, inhibited or prevented in accordance with the third aspect of the present invention.", "One form of biofilm of particular interest in certain embodiments of the third aspect of the present invention is biofilm that forms dental plaque.", "The effectiveness of the present invention against dental plaque is demonstrated in Example 17.The biofilm in dental plaque typically comprises a variety of microbial organisms, including both aerobic and anaerobic bacteria, and typically includes over 700 different species of bacteria and archaea.", "Dental plaque biofilms are responsible for many of the diseases common to the oral cavity including dental caries, periodontitis, gingivitis, and the less common peri-implantitis (similar to periodontitis, but with dental implants), however biofilms can be present on healthy teeth as well.", "Accordingly.", "the third aspect of the present invention also provides methods and uses for preventing or inhibiting the formation of, for treating, or for reversing or removing conditions including dental plaque, dental caries, periodontitis, gingivitis, and the less common peri-implantitis.", "Said method or use may comprise administering a composition according to the third aspect of the present invention to the mouth of a subject, thereby to achieve the intended effect.", "In the context of dental products, and in the context of inhibiting and/or removing dental plaques, an effective concentration of 340 μM is demonstrated in Example 17, although higher or lower concentrations of the one or more compounds according to section III.A below may also be suitable.", "For example, dental products may present the buccal cavity or teeth with one or more of said compounds at a concentration within the range of about 1 μM to about 1M, such as about, or up to, 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 90 μM, 100 μM, 110 μM, 120 μM, 130 μM, 140 μM, 150 μM, 160 μM, 170 μM, 180 μM, 190 μM, 200 μM, 210 μM, 220 μM, 230 μM, 240 μM, 250 μM, 260 μM, 270 μM, 280 μM, 290 μM, 300 μM, 310 μM, 320 μM, 330 μM, 340 μM, 350 μM, 360 μM, 370 μM, 380 μM, 390 μM, 400 μM, 410 μM, 420 μM, 430 μM, 440 μM, 450 μM, 460 μM, 470 μM, 480 μM, 490 μM, 500 μM, 510 μM, 520 μM, 530 μM, 540 μM, 550 μM, 560 μM, 570 μM, 580 μM, 590 μM, 600 μM, 610 μM, 620 μM, 630 μM, 640 μM, 650 μM, 660 μM, 670 μM, 680 μM, 690 μM, 700 μM, 710 μM, 720 μM, 730 μM, 740 μM, 750 μM, 760 μM, 770 μM, 780 μM, 790 μM, 800 μM, 810 μM, 820 μM, 830 μM, 840 μM, 850 μM, 860 μM, 870 μM, 880 μM, 890 μM, 900 μM, 910 μM, 920 μM, 930 μM, 940 μM, 950 μM, 960 μM, 970 μM, 980 μM, 990 μM, 1 mM, 2 mM, 3 mM, 4 mM, 5 mM, 6 mM, 7 mM, 8 mM, 9 mM, 10 mM, 15 mM, 20 mM 25 mM, 30 mM, 35 mM, 40 mM, 45 mM, 50 mM, 60 mM, 70 mM, 80 mM, 90 mM, 100 mM, 150 mM, 200 mM, 250 mM, 300 mM, 350 mM, 400 mM, 450 mM, 500 mM, 600 mM, 700 mM, 800 mM, 900 mM, 1M or more.", "Optionally, the concentration may be: (a) up to 1 μM, 2 μM, 3 μM, 4 μM, 5 μM, 10 μM, 15 μM, 20 μM, 25 μM, 30 μM; (b) within a range selected from the group consisting of from 35 to 335 μM, 40 to 300 μM, 50 to 300 μM, 50 to 250 μM, 50 to 200 μM, 60 to 300 μM, 60 to 250 μM, 60 to 200 μM, 80 to 300 μM, 80 to 250 μM, 80 to 200 μM, 100 to 300 μM, 100 to 250 μM, or 100 to 200 μM; or (c) at least, or about, 345 μM, 350 μM, 360 μM, 370 μM, 380 μM, 390 μM, 400 μM, 450 μM, 0.5 mM, 1 mM, 2 mM or more.", "Optionally the concentration of the one or more compounds may be within a range selected from the group consisting of from about 1 μM to about 1 mM, or about 30 μM to about 0.5 mM, or about 60 μM to about 0.4 mM.", "Another form of biofilm of particular interest to the third aspect of the present invention is biofilm on medical devices, including contact lenses.", "Biofilms on contact lenses may, for example, comprise, consist essentially of, or consist of one or more bacteria selected from Archromobacter, Delftia, Staphylococcus, Stenotrophomonas, and Streptococci species, and Pseudomonas aeruginosa.", "Another form of biofilm of particular interest in the present invention is biofilms formed on the skin, for example biofilms which comprise, consist essentially of, or consist of Propionibacterium acnes.", "Accordingly.", "the third aspect of the present invention also provides methods and uses for preventing or inhibiting the formation of, for treating, or for reversing or removing acne and other microbially-induced skin conditions, including recalcitrant and/or anti-biotic resistant conditions, the method or use comprising the topical administration of a composition according to the third aspect of the present invention to the skin of a subject, thereby to achieve the intended effect.", "Another form of biofilm which may, or may not, be of particular interest in the third aspect of the present invention is biofilms that comprise, consist essentially of, or consist of, epsilon proteobacteria class, such as the spirilloid Wolinella spp., Helicobacter spp., and most particularly Campylobacter spp.", "In one embodiment, the application of the third aspect of the present invention to biofilms that comprise, consist essentially of, or consist of, Campylobacter spp.", "may, or in another option may not, be of interest.", "Many other types of biofilms are of interest for the present invention, further examples of which are discussed in further sections of this application.", "Campylobacter are gram negative, spiral rod shaped bacteria with a single flagellum at one or both poles.", "They belong to the epsilon proteobacteria class and are closely related to Helicobacter and Wolinella.", "At least a dozen species of Campylobacter have been implicated in human disease, with C. jejuni and C. coli the most common.", "Campylobacter jejuni is the major cause of human bacterial gastroenteritis (Pearson, et al., Appl Environ Microbiol., 59:987-996 (1993)).", "The four major sources of infection are raw meat (particularly poultry), untreated water, raw milk, and pets (Humphrey, et al., J Appl Bacteriol.", "61:125-132.", "(1986) and Skirrow, Int J Food Microbiol., 12:9-16 (1991)).", "It has also been suggested that, although not universally the case (Humphrey, et al., Public Health Lab Serv Microbiol Digest., 13:86-88.91996), Jacobs-Reitsma, et al., Epidemiol Infect., 114:413-421 (1995), and Lindblom, et al., J Hyg., 96:385-391 (1986)), survival in the water systems of animal husbandry facilities and animal-processing units promotes infection in animals and cross-contamination of animal carcasses (Humphrey, et al., Epidemiol Infect., 98:263-269 (1987), Kazwala, et al., Vet Rec.", "1990; 126:305-306.", "(1990) and, Pearson, et al., Appl Environ Microbiol., 59:987-996 (1993)).", "Thus, the survival of C. jejuni in aquatic environments is important both directly and indirectly in the causation of human disease.", "Campylobacter spp.", "have outer membrane proteins (OMPs) (Buchanan, Curr.", "Opin.", "Struc.", "Biol., 9(40:455-461 (1999); Huyer, et al., FEMS Microbiol.", "Lett., 37(3):247-250 (1986)].", "The major outer membrane proteins (MOMPs) have unique structural features, and function as porins which are helpful for linking up the bacteria and their environment.", "Campylobacter spp.", "possess polar flagella which provide the necessary motility for intestinal colonization.", "The flagellin gene of Campylobacter has two similar copies: flaA and flaB.", "The length of coding regions for the flaA and flaB sequences are both around 1.7 kilobases, and flaA and flaB sequences locate about 180 bases apart from each other (Meinersmann, et al., Microbiology, 146(9):2283 (2000)).", "In one embodiment of the third aspect of the present invention, the disclosed compositions bind to major outer membrane proteins (MOMPs) or FlaA of Campylobacter and prevent the bound MOMPs and bound FlaA from binding or associating with their ligands on: other Campylobacter bacteria; other species of bacteria; biofilm or biofilm components; or to surfaces.", "By binding to the MOMPs and FlaA, the compounds inhibit the bacteria from binding to surfaces or each other to produce biofilm.", "The inhibition of binding can be accomplished by interfering with the binding of natural ligands of MOMPs or FlaA or by physically inhibiting the association of the bacteria expressing MOMPs or FlaA to other organisms or surfaces.", "In another embodiment of the third aspect of the present invention, the disclosed compositions also bind to the MOMP protein of Campylobacter when MOMP has been mutated to prevent O-glycosylation by mutation of Thr-268 to glycine to form MOMP-T (also referred to as MOMPT268G).", "As shown in Table 1, expression of the MOMPT268G protein has been found to increase 10-fold compared with wildtype.", "Treatment of the MOMPT268G strain with the compositions does not impact planktonic growth, but does partially inhibit biofilm formation demonstrating the compositions bind to the non-glycosylated MOMP with lower affinity.", "As shown in Table 1, expression of the MOMPT268G protein has been found to increase 10-fold compared with wildtype.", "Regardless of whether MOMP is glycosylated or not, the compositions disclosed herein are still effective against mixed populations of glycosylated and non-glycosylated Campylobacter.", "In a mixed population of glycosylated and non-glycosylated forms, the wildtype glycosylated form of Campylobacter greatly outcompetes the mutant non-glycosylated form, and over time the non-glycosylated bacteria disappear and the glycosylated bacteria become the only bacteria present.", "Biofilms are usually found on solid substrates submerged in or exposed to an aqueous solution, although they can form as floating mats on liquid surfaces.", "Biofilms can form on a myriad of surfaces.", "For example, biofilms can grow in showers very easily since they provide a moist and warm environment for the biofilm to thrive.", "Biofilms can form inside water and sewage pipes and cause clogging and corrosion.", "Biofilms on floors and counters can make sanitation difficult in food preparation areas.", "Biofilms can form in cooling- or heating-water systems and are known to reduce heat transfer in these systems One method, or use, in accordance with a third aspect of the present invention includes administering an effective amount of the one or more compounds as defined in section III.A of this application to a subject in need thereof, to inhibit biofilm formations, or alternatively, to reduce and/or remove biofilm formation.", "The one or more compounds may be administered alone, or in combination with an antimicrobial agent, such as an antibiotic.", "In certain embodiments of the third aspect of the present invention, in the context of the treatment of subjects (such as humans or animals) it may be desirable to provide continuous delivery of one or more compounds to a subject in need thereof.", "For intravenous or intra-arterial routes, this can be accomplished using drip systems, such as by intravenous administration.", "For topical applications, repeated application can be done or a patch can be used to provide continuous administration of the compounds over an extended period of time.", "For example, the compounds may be delivered to a chronic wound from a wound dressing.", "The dressing may also contain one or more antibiotics, and if necessary the wound dressing may be changed frequently.", "The compounds may also be delivered in a conjugated form (for example, as shown in FIGS.", "15A-C and FIGS.", "16A and B) so that they are immobilized on a surface.", "In other embodiments of the third aspect of the present invention, the method includes contacting a surface with an effective amount of the compounds, to inhibit biofilm buildup, reduce built up biofilm, and/or remove built up biofilm.", "“Contacting” includes, but is not limited to, touching, impregnating, compounding, mixing, integrating, coating, spraying, dipping, flushing, irrigating, and wiping.", "In certain embodiments, it may be desirable to provide continuous delivery of one or more compounds to the surface or system being treated.", "The compositions can be used to coat, impregnate, flush, or rinse a surface of tubing or a medical device, especially an insertable medical device.", "Tubing includes, but is not limited to, disposable, permanent, and indwelling catheters, long term urinary devices, tissue bonding urinary devices, wound drain tubes, ventricular catheters, endotracheal tubes, breathing tubes, feeding tubes, dairy lines, oil and gas pipeline and drinking water lines.", "When an object is tubing (e.g., dental unit waterline, a dairy line, a food and beverage processing line, etc.", "), a composition may be poured into the tubing and both ends of the tubing clamped such that the composition is retained within the lumen of the tubing.", "The tubing is then allowed to remain filled with the composition for a period of time sufficient to remove substantially all of the microorganisms from at least one surface of the object, generally, for at least about 1 minute to about 48 hours.", "Alternatively, tubing may be flushed by pouring a composition into the lumen of the tubing for an amount of time sufficient to prevent substantial growth of all biofilm embedded microorganisms.", "Such flushing may be required only once, or may be required at regular intervals over the lifetime of use of the tubing.", "Concentrations of active components in a composition may vary as desired or necessary to decrease the amount of time the composition is in contact with a medical device.", "The methods allow disinfection, inhibition, or prevention of biofilm formation on the surfaces being treated and reduction of transmission of biofilm forming microorganisms from the surface to another surface.", "The number of the bacterial colony forming units (cfu) on the surface being treated with the compounds may be reduced by 50%, by 60%, by 70%, by 80%, by 90% or by 100%, or, the buildup of bacterial colony forming units on the treated surface may be reduced by 50%, by 60%, by 70%, by 80%, by 90% or by 100%.", "In one embodiment of the third aspect of the present invention, compositions and articles, including but not limited to pharmaceutical and veterinary compositions, food or feed additive compositions, and dental products including chews may be prepared from the one or more compounds as defined above, optionally formulated and/or used in combination with one or more antibiotics or other anti-microbial agents, and these compositions may further be used for the treatment or prophylaxis of a microbial infection or biofilm formed by bacteria or other microorganisms, including one or more of the following: S. epidermidis, E. faecalis, E. coli, S. aureus including Vancomycin-resistant Staphylococcus aureus (VRSA) and Methicillin-resistant Staphylococcus aureus (MRSA), Enteropathogenic Escherichia coli (EPEC), Uropathogenic Escherichia coli (UPEC), Pseudomonas, Streptococcus pneumoniae, Streptococcus anginosus, Neisseria gonorrhoeae, Salmonella (including drug-resistant non-typhoidal, Salmonella including drug-resistant Salmonella serotype typhi, Salmonella Enteritidis, Salmonella Typhimurium, Mycoplasma, Eimeria, Enterococci, Shigella, Vancomycin-resistant Enterococcus (VRE), Erythromycin-resistant Group A Streptococcus, Clindamycin-resistant Group B Streptococcus, Carbapenem-resistant Enterobacteriaceae (CRE), drug-resistant tuberculosis, Extended spectrum Enterobacteriaceae (ESBL), multidrug-resistant Acinetobacter (including MRAB), Clostridium difficile, Enteropathogenic E. coli (EPEC), Pseudomonas aeruginosa, Brachyspira, Propionibacterium acnes, and Clostridium perfringen.", "2.Methods of Administration In one embodiment, the compounds and formulations, derivatives thereof and combinations thereof for use in accordance with the third aspect of the present invention can be administered topically to a subject in need thereof in an effective amount to prevent or treat a microbial infection, by inhibiting buildup of biofilm or to reduce and/or remove built up biofilm.", "Any suitable topical formulation can be used, for example as described in Section III.C.3 of this application, below, including emulsions (such as those described in section III.C.3(a)), lotions (such as those described in section III.C.3(b)), creams (such as those as described in section III.C.3(c)), ointments (such as those described in section III.C.3(d)), gels (such as those described in section III.C.3(e)), or foams (such as those described in section III.C.3(f)).", "The compositions may be used alone or in combination with known antimicrobial agents, such as those described further below in section III.B of this application.", "As such, compositions described in respect of the second aspect of the present invention may also be useful in the practice of the third aspect of the present invention.", "The compositions are useful for treating topical conditions caused by biofilm buildup by microorganisms including, but not limited to gram-negative and gram-positive bacteria, including Staphylococcus (including, but not limited to S. aureus and Staphylococcus epidermidis), Pseudomonas, E.", "coli., Streptococcus pyogenes (Reviewed in Nusbaum, et al., Skin Therapy Lett., 17(7):1-5 (2012)), Propionibacterium acnes and Streptococcus anginosus.", "In some embodiments the compositions are used as a topical antibacterial medication for skin infections caused by methicillin-resistant Staphylococcus aureus.", "Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that is resistant to many antibiotics.", "The spectrum of disease caused by MRSA appears to be similar to that of Staphylococcus aureus in the community.", "Soft tissue infections (SSTIs), specifically furuncles (abscessed hair follicles or “boils”), carbuncles (coalesced masses of furuncles), and abscesses, are the most frequently reported clinical manifestations.", "The most common manifestations of community associated-MRSA are simple skin infections, such as impetigo, boils, abscesses, folliculitis, and cellulitis.", "Others include children with minor skin infections (such as impetigo) and secondarily infected skin lesions (such as eczema, ulcers, or lacerations).", "The compositions can also be used to treat MRSA infections of the CNS, which include, but are not limited to Meningitis, Brain abscess, subdural empyema, spinal epidural abscess.", "Reviewed in Liu, et al., Clin Infect Dis., 52(3):e18-55 (2011).", "Additional examples of conditions that can be treated include atopic dermatitis, acne, bullous and non-bullous impetigo, pemphigus foliaceus, miliaria, feruncles (also known as boils) and chronic wounds such as diabetic foot ulcers, venous insufficiency ulcers, and pressure ulcers.", "In the context of treating acne, an effective concentration of 340 μM is demonstrated in Example 24, although higher or lower concentrations of the one or more compounds according to section III.A below may also be suitable for the treatment of acne and any of the other skin conditions as discussed herein.", "For example, the treatment of these skin conditions in accordance with the present invention may utilize one or more of said compounds at a concentration within the range of about 1 μM to about 1M, such as about, or up to, 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 90 μM, 100 μM, 110 μM, 120 μM, 130 μM, 140 μM, 150 μM, 160 μM, 170 μM, 180 μM, 190 μM, 200 μM, 210 μM, 220 μM, 230 μM, 240 μM, 250 μM, 260 μM, 270 μM, 280 μM, 290 μM, 300 μM, 310 μM, 320 μM, 330 μM, 340 μM, 350 μM, 360 μM, 370 μM, 380 μM, 390 μM, 400 μM, 410 μM, 420 μM, 430 μM, 440 μM, 450 μM, 460 μM, 470 μM, 480 μM, 490 μM, 500 μM, 510 μM, 520 μM, 530 μM, 540 μM, 550 μM, 560 μM, 570 μM, 580 μM, 590 μM, 600 μM, 610 μM, 620 μM, 630 μM, 640 μM, 650 μM, 660 μM, 670 μM, 680 μM, 690 μM, 700 μM, 710 μM, 720 μM, 730 μM, 740 μM, 750 μM, 760 μM, 770 μM, 780 μM, 790 μM, 800 μM, 810 μM, 820 μM, 830 μM, 840 μM, 850 μM, 860 μM, 870 μM, 880 μM, 890 μM, 900 μM, 910 μM, 920 μM, 930 μM, 940 μM, 950 μM, 960 μM, 970 μM, 980 μM, 990 μM, 1 mM, 2 mM, 3 mM, 4 mM, 5 mM, 6 mM, 7 mM, 8 mM, 9 mM, 10 mM, 15 mM, 20 mM 25 mM, 30 mM, 35 mM, 40 mM, 45 mM, 50 mM, 60 mM, 70 mM, 80 mM, 90 mM, 100 mM, 150 mM, 200 mM, 250 mM, 300 mM, 350 mM, 400 mM, 450 mM, 500 mM, 600 mM, 700 mM, 800 mM, 900 mM, 1M or more.", "Optionally, the concentration may be: (a) up to 1 μM, 2 μM, 3 μM, 4 μM, 5 μM, 10 μM, 15 μM, 20 μM, 25 μM, 30 μM; (b) within a range selected from the group consisting of from 35 to 335 μM, 40 to 300 μM, 50 to 300 μM, 50 to 250 μM, 50 to 200 μM, 60 to 300 μM, 60 to 250 μM, 60 to 200 μM, 80 to 300 μM, 80 to 250 μM, 80 to 200 μM, 100 to 300 μM, 100 to 250 μM, or 100 to 200 μM; or (c) at least, or about, 345 μM, 350 μM, 360 μM, 370 μM, 380 μM, 390 μM, 400 μM, 450 μM, 0.5 mM, 1 mM, 2 mM or more.", "Optionally the concentration of the one or more compounds may be in within a range selected from the group consisting of from about 1 μM to about 1 mM, or about 30 μM to about 0.5 mM, or about 60 μM to about 0.4 mM.", "Atopic dermatitis (AD) affects 10-20% of children with 60% of cases occurring within a child's first year and 85% before the age of 5 (Krakowski, et al., Pediatrics, 122(4):812-24 (2008)).", "Many cases persist into adulthood as evidenced by the 1-3% prevalence of AD among the adult population (Leung, et al., Lancet, 361(9352):151-60 (2003)).", "AD patients are colonized with S. aureus and this organism has been shown to exist in both dry skin as well as areas of severe dermatitis (Ikezawa, et al., Allergy Asthma Immunol Res., 2(4):235-46 (2010)).", "Disease severity has been directly correlated to the degree of S. aureus colonization and therapy generally fails to improve symptoms in the presence of high S. aureus counts (Akiyama, et al., J Dermatol Sci., 23(3):155-6 (2000)).", "Confocal laser scanning micro has demonstrated the presence of biofilms in skin stripping and biopsy specimens from AD patients (Akiyama, et al., Br J Dermatol., 148(3):526-32 (2003)).", "The presence of S. aureus biofilms have been shown in specimens of bullous impetigo and pemphigus foliaceus (Akiyama, et al., Br J Dermatol., 148(3):526-32 (2003)) while biofilms containing both S. aureus and Streptococcus pyogenes have been identified in non-bullous impetigo (Akiyama, et al., J Dermatol Sci., 32(3):193-9 (2003)).", "The difficulty in eradicating S. aureus colonization with conventional antibiotic therapy may be due to the presence of biofilms.", "Biofilm formation has also been demonstrated in a murine model inoculated with S. aureus isolated from a furuncle (Yamasaki, et al., J Antimicrob Chemother., 48(4):573-7 (2001)).", "Biofilms have been implicated in miliaria by a clinical study in which only extracellular polymeric substance (EPS) producing S. epidermidis was capable of inducing lesions after inoculation and occlusion (Mowad, et al., J Am Acad Dermatol., 33(5 Pt 1):729-33 (1995)).", "Biopsy specimens revealed sweat glands blocked with EPS material, further supporting a pathogenic role for biofilms in this condition.", "Several factors, for example, firm adherence of dermatophytes to the nail plate, presence of dormant fungal elements, ability of yeast to form biofilms, and difficulty of eradication all suggest that biofilm involvement in onychomycosis (Burkhart, et al., J Am Acad Dermatol., 47(4):629-31 (2002)).", "Chronic wounds present an optimal environment for microbial proliferation.", "In a clinical study of 66 wounds of various etiologies, 60% of chronic wounds were shown to contain biofilms as compared to 6% of acute wounds, indicating a role of biofilms in wound chronicity.", "Traditional cultures identified Staphylococcus, Pseudomonas, and Enterococcus as the predominant organisms (James, et al., Wound Repair Regen., 16(1):37-44 (2008).", "In a preferred embodiment, the compounds may be incorporated into wound irrigation solutions.", "In another preferred embodiment, the compounds may be incorporated into cosmetic formulations.", "The compositions of the compounds according to the third aspect of the present invention are also useful in oral health for both prophylaxis and treatment of infections.", "For example, the compounds may be used to treat or prevent infections in dental pulp by Streptococcus anginosus, or prevent attachment of biofilms to tooth surfaces.", "The compounds may be applied directly to tooth surfaces or applied to dental pulp during a procedure.", "The compounds may also be incorporated into dental products such as toothpaste, mouthwash, floss, toothpicks, and chewable products (including food products), a mouth shield, a dental instrument, dentures, dental retainers, dental braces including plastic braces (such as Invisalign), bristles of toothbrushes, dental prostheses and orthodontic devices, chewable non-food items, or foods, as well as applied as coatings directly to dental tissues.", "The compositions may be used for dental care of both humans and animals, including pets such as dogs and cats as well as livestock and horses.", "For example, the compounds may be incorporated into chewable foods or toys, such as dog bones and biscuits.", "In fact, in one embodiment of particular interest to the present invention, there is provided a human or animal (especially a dog) chew composition comprising one or more compounds as defined in Section III.A.", "Exemplary dog and other animal chews which can be modified to include the one or more compounds as defined in Section III.A include those described in U.S. Pat.", "No.", "6,086,940, the contents of which are incorporated herein by reference.", "Further exemplary chews include the Oravet® dental hygiene chew produced by Merial (see http://merial.com/en/press-releases/merial-introduces-oravet-dental-hygiene-chews-for-dogs/, the contents of which are incorporated herein by reference) and the Kalloodles dental chews (see http://kanoodlesusa.com/, the contents of which are incorporated herein by reference).", "Dental chews in accordance with the present invention can be used in dogs and other animals to inhibit the production of biofilms that form plaque, and/or to reduce or treat or prophylactically treat halitosis.", "Chewing said chews may also help scrub away existing plaque and/or calculus.", "Optionally, the chews may be usefully used regularly, such as daily and optionally daily after one or more meals.", "The compounds may, in accordance with the third aspect of the present invention, be added to drinking water or other drinkable fluids.", "Other modes of administration in accordance with the third aspect of the present invention can include: (i) Parenteral administration, which may include administration to a patient intravenously, intradermally, intraarterially, intraperitoneally, intralesionally, intracranially, intraarticularly, intraprostatically, intrapleurally, intratracheally, intravitreally, intratumorally, intramuscularly, subcutaneously, subconjunctivally, intravesicularly, intrapericardially, intraumbilically, by injection, and by infusion, for example as further described in Section III.C.1 of this application, below.", "Parenteral administration can include the use of formulations as described herein which are formulated for controlled release including immediate release, delayed release, extended release, pulsatile release, and combinations thereof, as further described in Section III.C.1(a) of this application, below.", "(ii) The compounds can be incorporated into injectable/implantable solid or semi-solid implants, such as polymeric implants, for example as further described in Section III.C.1(b) of this application, below.", "(iii) Enteral administration, including administration in the form of suitable oral dosage forms such as tablets, capsules, solutions, suspensions, syrups, and lozenges, for example, as further described in Section III.C.2 of this application, below.", "Optionally, enteral administration may include administration of controlled release enteral formulations, including oral dosage forms, such as capsules, tablets, solutions, and suspensions, which are formulated for controlled release, including extended and/or delayed release, such as described in more detail below in Section III.C.2(a) of this application.", "(iv) The administration of one or more disinfecting formulations or cleaning formulations, such as those described in Section III.C.4 of this application, below.", "3.Hospital and Other Environments The methods and uses of the third aspect of the present invention may be practiced in the hospital and also in other medical and non-medical environments in order to address, inhibit, treat, ameliorate and/or disrupt biofilms.", "Further examples of microbial infection and colonizations and biofilm formations that can be addressed by the third aspect of the invention are discussed further below, and also further define medical uses and methods in accordance with the third aspect of the present invention for the treatment and/or prophylaxis of subjects (including humans and animals) in need thereof.", "For example, S. epidermidis contributes to biofilms that grow on plastic devices placed within the body (Otto, Nature Reviews Microbiology, 7(8):555-567 (2009)).", "This occurs most commonly on intravenous catheters and on medical prostheses (Hedin, Scandinavian Journal of Infectious Diseases Supplementum, 90:1-59 (1993)).", "Infection can also occur in dialysis patients or anyone with an implanted plastic device that may have been contaminated.", "Another disease it causes is endocarditis.", "This occurs most often in patients with defective heart valves.", "In some other cases, sepsis can occur in hospital patients.", "As a further example, Methicillin-resistant S. aureus (MRSA), is one of a number of greatly feared strains of S. aureus which have become resistant to most β-lactam antibiotics.", "MRSA strains are most often found associated with institutions such as hospitals, but are becoming increasingly prevalent in community-acquired infections.", "A recent study by the Translational Genomics Research Institute showed that nearly half (47%) of the meat and poultry in U.S. grocery stores were contaminated with S. aureus, with more than half (52%) of those bacteria resistant to antibiotics (ScienceDaily, 15 Apr.", "2011).", "In another example, Enterococcus faecalis causes many of the antibiotic resistant infections in hospitals, a consequence of its inherent resistance to certain antibiotics and its ability to survive and proliferate in the intestinal tract.", "Escherichia coli is one of the most frequent causes of many common bacterial infections, including cholecystitis, bacteremia, cholangitis, urinary tract infections other clinical infections such as neonatal meningitis and pneumonia.", "For example, the compositions can be used to treat (for example, as adjunct therapy) conditions caused by community- and/or hospital-acquired urinary tract infections (UTI's) caused by strains of Escherichia coli (drug resistant or otherwise) in immunocompromised patients.", "In accordance with a further example, the aggressive colonization of stainless steel surfaces by P. aeruginosa for example, apart from being of enormous industrial significance, is also of medical relevance; P. aeruginosa infections are prevalent in burn units where large stainless steel tubs, known as hydrotherapy units, are often used to treat patients with severe burns.", "Antibiotics are largely ineffective in clearing biofilms, although the third and second aspects of the present invention may be combined in order to potentiate the effect of antibiotics.", "The most common treatment for these infections is to remove or replace the infected implant, though in all cases, prevention is ideal.", "The drug of choice is often vancomycin, to which rifampin or aminoglycoside can be added.", "Hand washing has been shown to reduce the spread of infection.", "Accordingly, compositions in accordance with the third aspect of the present invention may include hand wash and/or hand spray compositions, and may be used accordingly in the treatment of hands and other body surfaces.", "Preliminary research also indicates S. epidermidis is universally found inside affected acne vulgaris pores, where Propionibacterium acnes is normally the sole resident (Bek-Thomson, et al., J. Clin.", "Microbiol., 46(10):3355-3360 (2008).", "a.", "Use as Disinfection Agent The one or more compounds for use in the third aspect of the present invention can, in accordance with a further embodiment, be used as disinfection (or pesticide) agents (the United States Environmental Protection Agency, “EPA”, defines biofilms as pestilent), for example, in high risk environments such as in hardware from hospitals or healthcare facilities.", "As such, the one or more compounds may be formulated as a disinfecting formulation or cleaning formulation, such as those described in Section III.C.4 of this application, below.", "In accordance with a further embodiment of the third aspect of the present invention, there is provided a method or use comprising the use of the disinfection agent in high-risk environments such as in hardware from hospitals or healthcare facilities, cosmetic, consumer and industrial applications, to prevent biofilm buildup or reduce biofilm from a surface of interest.", "In these embodiments, the compounds may, for example, be sprayed onto the surface in the form of a foam, solution or gel, or applied to the surface (wipe down) by means of a carrier for example tissue, material or other porous item containing the one or more compounds.", "A further embodiment of the third aspect of the present invention is a disinfection agent as described herein and also provided is a product or article treated with a disinfection agent as described herein.", "The World Health Organization (WHO) estimates that at any time, more than 1.4 million people worldwide are affected by infections acquired in hospitals.", "Cleaning, disinfection and sterilization saves lives and improves patient outcomes.", "Between 5% and 10% of patients admitted to modern hospitals in the developed world acquire one or more healthcare-associated infections.", "The Centers for Disease Control and Prevention (CDC) estimate that approximately 1.7 million healthcare-associated infections occur annually in hospitals in the United States, and are associated with nearly 100,000 deaths each year.", "Healthcare-associated infections are also an important problem in extended care facilities, including nursing homes and rehabilitation units.", "Transmission of healthcare-associated pathogens most frequently occurs via the hands of healthcare workers, who inadvertently contaminate their hands during various patient care activities.", "Less frequently, contaminated surfaces in healthcare facilities may contribute to the spread of healthcare-associated pathogens.", "The varying levels of disinfection used in a healthcare facility may be defined by Spaulding's Classification (Sehulster, et al., Guidelines for environmental infection control in health-care facilities.", "Recommendations from CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC).", "Chicago Ill.; American Society for Healthcare Engineering/American Hospital Association; 2004.).", "Spaulding's levels, non-critical, semi-critical, and critical, are based on the potential for infectious disease spread via equipment, instruments, and furniture as well as the level of sterility normally required for the body part coming in contact with it.", "Levels of disinfection that correlate with Spaulding's classification are low, intermediate, high, and sterilization.", "The US Centers for Disease Control (CDC) has further delineated disinfection levels for environmental surfaces in its “Guidelines for Environmental Infection Control in Health-Care Facilities”.", "Critical items confer a high risk for infection if they are contaminated with any microorganism.", "Thus, the third aspect of the present invention also provides objects treated for sterilization as described herein, which objects enter sterile tissue or the vascular system and must be sterile because any microbial contamination could transmit disease.", "This category includes surgical instruments, cardiac and urinary catheters, implants, and ultrasound probes used in sterile body cavities.", "Semi critical items contact mucous membranes or nonintact skin.", "This category includes respiratory therapy and anesthesia equipment, some endoscopes, laryngoscope blades, esophageal manometry probes, cystoscopes, anorectal manometry catheters, and diaphragm fitting rings.", "These medical devices should be free from all microorganisms; however, small numbers of bacterial spores are permissible.", "Specific examples of critical or semi critical instruments include invasive endoscopes such as laparoscopes, and rigid instruments with no operating channel Arthroscopes and laparoscopes which are inserted into sterile body cavities as well as accessory instrumentation should be sterile.", "Other examples include gastroscopes, duodenoscopes, sigmoidoscopes, proctoscopes, colonoscopes, bronchoscopes, and laryngoscopes.", "The compounds may also be used in accordance with the third aspect of the present invention as food processing aids.", "For example, solutions of the one or more compounds as defined in section III.A below could be sprayed on animal carcasses or products (include meat part products) derived therefrom (i.e.", "poultry, fish, and meat or others, for example, as described in respect of the first aspect of the present invention) to prevent or inhibit colonization by bacteria, or inactivate biofilm formation.", "The compounds could, for example, be applied by dipping chicken (or other animal) carcasses or product derived therefrom in a container of a solution of the compounds, or by spraying an animal carcass with a solution of the compounds.", "In a preferred embodiment, aqueous solutions of FeQ, FeTyr, FeDOPA and/or Fe-Phe may be used as food processing aids.", "After treatment, the compounds may, if desired, be removed by washing.", "A further embodiment of the third aspect of the present invention provides an animal carcass (such as a chicken or other poultry, fish or other meat) and/or products (include meat part products) derived therefrom which have been treated, for example by spraying or dipping, in accordance with the third aspect of the present invention, and optionally wherein the one or more compounds are subsequently removed fully or partially by washing.", "b.", "Use as a Coating In other embodiments of the third aspect of the present invention, the one or more compounds having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application, can be incorporated into coatings used to coat medical devices, and other articles.", "Accordingly, the third aspect of the present invention also provides a method of coating a device or other article, comprising applying a coating comprising, consisting essentially of, or consisting of, one or more compounds having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application.", "The third aspect of the present invention also provides coated devices or articles, having a coating comprising, consisting essentially of, or consisting of, one or more compounds having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application.", "Suitable coating methods are known in the art.", "Methods for coating medical devices are disclosed for example in U.S.", "Publication Nos.", "20030054090 and 20120276280 and U.S. Pat.", "Nos.", "5,879,697, 7,247,338 and 8,028,646.The compounds can be applied to medical devices and other articles in any number of ways, including, but not limited to, ionic binding to a surface coating, passive adsorption, or dispersion within a polymeric base material making up the surface of the device or coated on the device surfaces (for example by dip coating, spray coating, ultrasonic spray coating, melt processing, application of films, solvent coating, etc.).", "In a preferred embodiment, the one or more compounds are combined with polymers, and coated on medical devices or other articles.", "Suitable polymers include, but are not limited, to poly(lactides); poly(glycolides); poly(lactide-co-glycolides); poly(lactic acid); poly(glycolic acid); poly(lactic acid-co-glycolic acids); polycaprolactones; poly(orthoesters); polyanhydrides; poly(phosphazenes); polyhydroxyalkanoates [including poly-3-hydroxybutyrate, poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV), poly-4-hydroxybutyrate, poly-3-hydroxybutyrate-co-4-hydroxybutyrate]; synthetically or biologically prepared polyesters (including polyesters with one or more of the following monomeric units: glycolic, lactic; trimethylene carbonate, p-dioxanone, or ε-caprolactone); poly(lactide-co-caprolactones); polyesters; polycarbonates; tyrosine polycarbonates; polyamides (including synthetic and natural polyamides, polypeptides, and poly(amino acids)); polyesteramides; poly(dioxanones); poly(alkylene alkylates); polyethers (such as polyethylene glycol, PEG, and polyethylene oxide, PEO); polyvinyl pyrrolidones or PVP; polyurethanes; polyetheresters; polyacetals; polycyanoacrylates; poly(oxyethylene)/poly(oxypropylene) copolymers; polyacetals, polyketals; polyphosphates; (phosphorous-containing) polymers; polyphosphoesters; polyalkylene oxalates; polyalkylene succinates; poly(maleic acids); chitin; chitosan; modified chitosan; collagen; silk; biocompatible polysaccharides; biocompatible copolymers (including block copolymers or random copolymers); hydrophilic or water soluble polymers, such as polyethylene glycol, (PEG) or polyvinyl pyrrolidone (PVP), with blocks of other biocompatible or biodegradable polymers, for example, poly(lactide), poly(lactide-co-glycolide, or polycaprolcatone or combinations thereof, polymers and copolymers of ethylene and propylene, including ultra-high molecular weight polyethylene, ultra-high molecular weight polypropylene, nylon, polyesters such as poly(ethylene terephthalate), poly(tetrafluoroethylene), polyurethanes, poly(ether-urethanes), poly(methylmethacrylate), polyether ether ketone, polyolefins, Dacron, latex, silicones, polymeric cements, and poly(ethylene oxide).", "In another preferred embodiment of the third aspect of the present invention, the one or more compounds can be first conjugated with other agents that have an affinity for, or can react with, a surface, and thereby immobilized on a surface.", "For example, the compounds can be tethered to a linkage that can be photo-activated to bind to a surface, or activated via another mechanism.", "Examples of devices and articles that can be coated using the compositions include tubing and other surface medical devices, such as urinary catheter, stents, mucous extraction catheter, suction catheter, umbilical cannula, contact lenses, intrauterine devices, intravaginal and intraintestinal devices, endotracheal tubes, bronchoscopes, dental prostheses and orthodontic devices, dentures, teeth, surgical instruments, dental instruments, tubing, dental water lines, dental drain tubes, fabrics, paper, indicator strips (e.g., paper indicator strips or plastic indicator strips), adhesives (e.g., hydrogel adhesives, hot-melt adhesives, or solvent-based adhesives), bandages, tissue dressings or healing devices and occlusive patches, and any other surface devices used in the medical field.", "Devices may include electrodes, external prostheses, fixation tapes, compression bandages, and monitors of various types.", "Medical devices also include any device that may be placed at the insertion or implantation site such as the skin near the insertion or implantation site, and which include at least one surface which is susceptible to colonization by biofilm embedded microorganisms.", "In one specific embodiment, a composition is integrated into an adhesive, such as tape, thereby providing an adhesive, which may prevent growth or proliferation of biofilm embedded microorganisms on at least one surface of the adhesive.", "Medical devices include surfaces of equipment in operating rooms, emergency rooms, hospital rooms, clinics, and bathrooms.", "In a particularly preferred embodiment the following devices may be coated with the compounds: catheters, including central venous catheters, urinary catheters, dialysis catheters, and indwelling catheters (for example, catheters for hemodialysis and for administration of chemotherapeutic agents), cardiac implants including mechanical heart valves, stents, ventricular assist devices, pacemakers, cardiac rhythm management (CRM) devices, cardiac resynchronization therapy devices (CRTs), and implantable cardioverter defibrillators (ICDs), synthetic vascular grafts, arteriovascular shunts, cerebral spinal fluid shunts, cochlear devices, prosthetic joints, orthopedic implants, internal fixation devices, bone cements, percutaneous sutures, surgical mesh and surgical patches including hernia repair meshes and patches, breast reconstruction meshes and patches, meshes and patches for breast and face lifts, slings, and meshes and patches for pelvic floor reconstruction, tracheal and ventilator tubing, wound dressings, biological implants (including allografts, xenografts and autografts), penile implants, intrauterine devices, endotracheal tubes, and contact lenses.", "Other articles that can be coated in accordance with the third aspect of the present invention include articles for use in rearing animals, such as animals and articles mentioned in the context of the first aspect of the present invention.", "Yet other articles that can be coated in accordance with the third aspect of the present invention include articles for use in the process of slaughter and/or processing the carcasses or parts thereof of animals, such as animals and articles mentioned in the context of the first aspect of the present invention.", "Yet further articles that can be coated in accordance with the third aspect of the present invention include articles for the preparation and/or containment of food stuffs, including foodstuffs comprising raw or cooked meats, eggs, dairy products or other food products.", "The food products may be human and/or animal food products.", "Yet further articles that can be coated in accordance with the third aspect of the present invention include articles for the preparation and/or containment of drinks.", "Accordingly, in another embodiment of the third aspect of the present invention there is provided a method of disinfecting a surface, or protecting a surface against infection, in need thereof, the method comprising contacting the surface with an effective amount of one or more compounds having the structure of having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application, wherein the one or more compounds are coated onto the surface to be disinfected.", "In some embodiments the one or more compounds may be applied to the surface in the form of a spray, an aerosol, or a foam.", "The coated surface may, for example, be formed on the surface of an instrument selected from the group consisting of surgical instruments, cardiac and urinary catheters, implants, and ultrasound probes used in sterile body cavities.", "The coated surface may, for example, be formed on the surface of a device selected from the group consisting of urinary catheter, stents, mucous extraction catheter, suction catheter, umbilical cannula, contact lenses, intrauterine devices, intravaginal and intraintestinal devices, endotracheal tubes, bronchoscopes, dental prostheses and orthodontic devices, surgical instruments, dental instruments, tubing, dental water lines, dental drain tubes, fabrics, paper, indicator strips (e.g., paper indicator strips or plastic indicator strips), adhesives (e.g., hydrogel adhesives, hot-melt adhesives, or solvent-based adhesives), bandages, tissue dressings or healing devices and occlusive patches, catheters, including central venous catheters, urinary catheters, dialysis catheters, and indwelling catheters, cardiac implants, mechanical heart valves, stents, ventricular assist devices, pacemakers, cardiac rhythm management (CRM) devices, cardiac resynchronization therapy devices (CRTs), and implantable cardioverter defibrillators (ICDs), synthetic vascular grafts, arteriovascular shunts, cerebral spinal fluid shunts, cochlear devices, prosthetic joints, orthopedic implants, internal fixation devices, bone cements, percutaneous sutures, surgical mesh and surgical patches including hernia repair mesh, breast reconstruction mesh, mesh for breast and face lifts, slings, and mesh for pelvic floor reconstruction, tracheal and ventilator tubing, wound dressings, biological implants, penile implants, intrauterine devices, endotracheal tubes, and contact lenses.", "The coated surface may, for example, be formed on the surface of an article selected from the group consisting of an industrial pipeline, liquid distribution lines, oil and gas pipelines and cosmetic container.", "The coated surface may, for example, be formed on the surface of, or be incorporated into, or onto, a household item, such as an item selected from the group consisting of household disinfectants; laundry detergent; cleaning supplies; equipment involved in the leeching process or mining; wound care; toothpaste; mouth wash; dental floss; toothpicks; chewable products (including food products); a mouth shield; a dental instrument; dentures; dental retainers; dental braces including plastic braces (such as Invisalign); bristles of toothbrushes; dental prostheses and orthodontic devices; chewable non-food items, foods, or toys, such as dog bones and biscuits; a vacuum system; HVAC ((heating, ventilation and air conditioning)) systems; vacuum cleaner bags; paint covering; wall coverings; window frames; doors; door frames; cooling towers; humidifiers; vacuum cleaners; filters such as a vacuum filter, a humidifier filter, hot tub filter, or a swimming pool filter; toys; plastic bottles; water jugs; tap and water spout; washing machines; dishwashers; animal water dishes; bathroom tiles and fixtures; sinks; showers; shower heads; toilets; toilets lids; toilet seats; sealants and grout; towels; TUPPERWARE®; dishes; cups; utensils such as forks, spoons, knives, and spatulas; bowls; food storage containers; beverage storage containers; cutting boards; dish drying trays; garbage bags; sinks; fish ponds; swimming pools; swimming pool liners; swimming pool skimmer; pond liners; bird baths; garden hose; water sprinkling lines; planters; and hot tubs.", "The coated surface may, for example, be formed on the surface of, or incorporated into, or onto, an article, device or apparatus used in the rearing and/or transport of animals, such as a chicken, for example, a meat-type chicken such as broiler chicken, or an egg-laying chicken such as a pullet or hen, or a breeder chicken, other poultry, such as a turkey, geese, quail or ducks, or livestock, such as cattle, sheep, goats or swine, alpaca, banteng, bison, camel, cat, deer, dog, donkey, gayal, guinea pig, horse, llama, mule, rabbit, reindeer, water buffalo, yak, although the skilled person will appreciate that other feeds for animals, including zoo animals, captive animals, game animals, fish (include freshwater and saltwater fish, farmed fish, and ornamental fish), other marine and aquatic animals, including shellfish such as, but not limited to, oysters, mussels, clams, shrimps, prawns, lobsters, crayfish, crabs, cuttlefish, octopus, and squid, domestic animals such as cats and dogs, rodents (such as mice, rats, guinea pigs, hamsters), and horses, are also provided, as well as any other domestic, wild and farmed animal, including mammals, marine animals, amphibians, birds, reptiles, insects and other invertebrates.", "In some embodiments, the device or apparatus used in the rearing and/or transport of animals may be selected from an article, device or apparatus that is for the delivery and/or containment of animal feed and/or animal drinking water.", "The coated surface may, for example, be formed on the surface of, or incorporated into, or onto, an article, device or apparatus used in the rearing, housing and/or transport of animals, such as a chicken, for example, a meat-type chicken such as broiler chicken, or an egg-laying chicken such as a pullet or hen, or a breeder chicken, other poultry, such as a turkey, geese, quail or ducks, or livestock, such as cattle, sheep, goats or swine, alpaca, banteng, bison, camel, cat, deer, dog, donkey, gayal, guinea pig, horse, llama, mule, rabbit, reindeer, water buffalo, yak, although the skilled person will appreciate that other feeds for animals, including zoo animals, captive animals, game animals, fish (include freshwater and saltwater fish, farmed fish, and ornamental fish), other marine and aquatic animals, including shellfish such as, but not limited to, oysters, mussels, clams, shrimps, prawns, lobsters, crayfish, crabs, cuttlefish, octopus, and squid, domestic animals such as cats and dogs, rodents (such as mice, rats, guinea pigs, hamsters), and horses, are also provided, as well as any other domestic, wild and farmed animal, including mammals, marine animals, amphibians, birds, reptiles, insects and other invertebrates.", "In some embodiments, the article, device or apparatus used in the rearing, housing and/or transport of animals can include one or more of an article, device or apparatus used in the production, creation, collection, storage, processing and/or packaging of an animal product.", "For example, an animal product may be a by-product of the animal (e.g.", "milk, eggs, or wool) or a downstream product thereof.", "Alternatively, an animal product may be the body or part of the body of the animal, and the harvesting process optionally includes the step of slaughtering the animal and further optionally preparing an animal carcass or part thereof as a product, such as a meat product.", "The third aspect of the present invention also, therefore, provides a device, article, product, item, formulation, composition or coating per se, having a coating comprising one or more compounds having the structure or having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application, and for their use in the above-defined methods.", "In one embodiment, the device, article, product, item, formulation, composition or coating comprises the one or more compounds in the coating in an amount effective to prevent biofilm formation.", "In another embodiment, the device, article, product, item, formulation, composition or coating comprises the one or more compounds in the coating in an amount effective to treat or reduce biofilm formation.", "The third aspect of the present invention also provides the direct per se products of the above-defined methods and uses of the third aspect of the present invention, and downstream product produced therefrom.", "The third aspect of the present invention also provides a compound conjugated to a structure that can anchor to a surface, wherein the compound has the structure of having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application.", "It may be preferred that the compound is selected from the group consisting of a complex of an amino acid or an α-hydroxy acid with Fe III, such as a complex of quinic acid with Fe III, a complex of L-tyrosine with Fe III, a complex of L-DOPA with Fe III and/or a complex of L-phenylalanine with Fe III.", "Optionally, the compound may be selected from the group consisting of the compounds represented by Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, Formula IX, Formula X, Formula XI, Formula XII, Formula XIII, Formula XIV, a compound that binds to major outer membrane proteins (MOMPs) or FlaA of Campylobacter, a synthetic human histo-blood group antigen, a mimetic of human histo-blood group antigen or a synthetic sugar.", "Also provided by the third aspect of the present invention is a composition comprising one or more conjugated compounds as defined above, and an article coated with one or more of said conjugated compounds, or with said composition.", "In one embodiment, the structure of the conjugated compound comprises hydroxyapatite or derivative thereof, and the conjugate is capable of anchoring, or is anchored to, a dental tissue.", "For example, in a further embodiment, conjugated forms of the compounds, such as those shown in FIGS.", "16A and B wherein the compounds are conjugated to hydroxyapatite may be applied to tooth tissues, such as tooth enamel, dentin and pulp in order to prevent dental caries and infection.", "In another embodiment, the compounds can be applied using photo-reactive chemistry, for example, using conjugated forms of the compounds such as those shown in FIGS.", "15A and B.", "4.Industrial, Cosmetic and Consumer Applications The compositions can be used in accordance with a further embodiment of the third aspect of the present invention to disinfect industrial surfaces, by preventing and/or removing biofilm buildup on such surfaces.", "In this embodiment, the formation of the biofilm may be prevented or inhibited, or a preformed biofilm may be removed by a method that comprises applying a composition of the present invention comprising the one or more compounds having the structure of Formula A or B, or other compounds of the present invention as described further in section III.A of this application, onto a surface in need thereof, for example as a spray, foam, gel, powders; dish or laundry detergents (liquid or solid), surface wax, glass cleaner, etc.", "Accordingly, the third aspect of the present invention also provides an object or article that has been treated in accordance with the foregoing method.", "Biofilms are continuously produced and often accumulate on numerous industrial surfaces and on biological surfaces.", "In an industrial setting, the presence of these biofilms causes a decrease in the efficiency of industrial machinery, requires increased maintenance, and presents potential health hazards.", "For example, the surfaces of water cooling towers become increasingly coated with microbially produced biofilm slime which both constricts water flow and reduces heat exchange capacity.", "Water cooling tower biofilms may also harbor pathogenic microorganisms such as Legionella pneumophila.", "Food preparation lines are routinely plagued by biofilm build-up both on the machinery and on the food product where biofilms often include potential pathogens.", "Biofilm formation comes with associated problems, such as accelerated deterioration of equipment through corrosion from cellular byproducts.", "There may also be a reduction in the efficacy of heat transfer and impairment of detection devices as the film disrupts transmission.", "Pseudomonas aeruginosa readily binds to stainless steel or plastic (e.g.", "polyvinylchloride, polystyrene) surfaces causing major problems in both the medical and food industries, forming biofilm.", "Biofilms readily form on PVC and glass surfaces under the static condition, especially in the food industry.", "a.", "Industrial Applications The compositions and coatings in accordance with the third aspect of the present invention can be used to clean, or maintain, pipelines and hoses in industries such as food and beverage industries, paper mills, sewage treatment, drainage, cooling towers and gas and oil industries by contacting a surface with biofilm growth with the composition.", "Industrial applications include their use in dairy lines, either as a flush or wash for such lines, or incorporated within the lines, for example as a coating; liquid distribution lines in the food and beverage manufacturing or dispensing, for example, use as a coating in feeder lines for high sugar or syrup distribution in the manufacturing of soft drinks; pulp and paper mills (for biofouling); in the manufacturing and containment of cosmetics from production line equipment down to the end consumable, either incorporated within the cosmetic or coated on the jar containing the cosmetic; in water treatment facilities; in the leaching process used in mining; to prevent corrosion caused or accelerated by organisms, in oil and gas pipelines including fracking pipes, in the souring souring of oil fields, in antifouling coatings (for example on submarines and boats), and in cooling towers.", "b.", "Consumer and Light Commercial Applications Consumer and light commercial uses of the compounds and coatings in accordance with the third aspect of the present invention include their incorporation in general household disinfectants; laundry detergent; cleaning supplies; equipment involved in the leeching process or mining; wound care; a vacuum system; HVAC (heating, ventilation and air conditioning) systems; vacuum cleaner bags; paint covering; wall coverings; window frames; doors; door frames; cooling towers; boat hulls, humidifiers; vacuum cleaners; filters and membranes, such as a vacuum filter, a humidifier filter, hot tub filter, osmosis membranes, or a swimming pool filter; toys; plastic bottles; water jugs; toothpaste, mouthwash, a tap and water spout; incorporation into plastics for a variety of household items including the inside and outside of washing machines and dishwashers; animal water dishes; bathroom tiles and fixtures; sinks; showers; shower heads; toilets; toilets lids; toilet seats; sealants and grout; towels; TUPPERWARE®; dishes; cups; utensils such as forks, spoons, knives, and spatulas; bowls; food storage containers; beverage storage containers; cutting boards; dish drying trays; garbage bags; bathtubs including whirlpool and jacuzzi bathtubs; sinks; fish ponds and tanks; swimming pools; swimming pool liners; swimming pool skimmer; pond liners; bird baths; garden hose; water sprinkling lines; planters; and hot tubs.", "c. Cosmetic Applications A further embodiment of the third aspect of the present invention provides cosmetics and cosmetic applications, as well as containers for cosmetics and applicators for cosmetics that incorporate and/or are coated by, the one or more compounds having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application.", "Cosmetics (also known as makeup or make-up) include care substances used to enhance the appearance or odor of the human body.", "They are generally mixtures of chemical compounds, some being derived from natural sources (including natural oils) and many being synthetics.", "A cosmetic may be a substance that is suitable to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions.", "Although soap is traditionally not considered to be a cosmetic, for the purposes of the present description the discussion of cosmetics can also be applied to soaps.", "Exemplary cosmetics include skin-care creams, lotions, powders, perfumes, lipsticks, fingernail and toe nail polish, eye and facial makeup, towelettes, permanent waves, colored contact lenses, hair colors, hair sprays and gels, deodorants, hand sanitizer, baby products, bath oils, bubble baths, bath salts, butters and many other types of products.", "A subset of cosmetics is called “make-up,” which refers primarily to coloring products intended to alter the user's appearance.", "Cosmetics that are meant to be used on the face and eye area are usually applied with a brush or the fingertips.", "Cosmetics may comprise a variety of organic compounds and inorganic compounds.", "Typical organic compounds can include modified natural oils and fats as well as a variety of petrochemically derived agents.", "Inorganic compounds can include processed minerals such as iron oxides, talc, and zinc oxide.", "The oxides of zinc and iron may be classified as pigments, i.e.", "colorants, and may have no solubility in solvents.", "The application of the third aspect of the present invention to cosmetics, cosmetic applications, cosmetic containers and/or cosmetic applicators may provide for methods to reduce, avoid, minimise or disrupt biofilms in the cosmetics, containers and/or applicators.", "Further, insofar as the applicant of the cosmetic to the body of the user achieves the delivery of one or more compounds having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application, then the cosmetics may be used to treat individuals in accordance with any of the embodiments of the second to third aspects of the present invention, particularly in the context of treating, reducing, prevent or disrupting bacterial infections, colonization, or biofilms on the skin, hair, nails, and/or in teeth of the user.", "5.Additional Medical Applications In a further embodiment of the third aspect of the present invention, the compounds having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application, and compositions comprising one or more of said compound, can be used to treat any medical condition associated with biofilm formation as a result of microorganisms including, but not limited to gram-negative and gram-positive bacteria, including Pseudomonas, H. pylori, E. feacalis, Campylobacter, E. coli, EPEC, UPEC and Staphylococcus.", "In addition to the conditions discussed above, rarer, but more serious manifestations of MRSA can occur, such as necrotizing fasciitis and pyomyositis (most commonly found in the tropics), necrotizing pneumonia, infective endocarditis (which affects the valves of the heart), and bone and joint infections.", "Additional conditions include severe or extensive disease (e.g., involving multiple sites of infection) or rapid progression in presence of associated cellulitis, signs and symptoms of systemic illness, associated comorbidities or immunosuppression, extremes of age, abscess in an area difficult to drain (e.g., face, hand, and genitalia), associated septic phlebitis, and lack of response to incision and drainage alone, purulent cellulitis, hospitalized patients with complicated SSTI (cSSTI; defined as patients with deeper soft-tissue infections, surgical/traumatic wound infection, and infected ulcers and burns), osteomyelitis, device-related osteoarticular infections.", "In a further embodiment, the compounds having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application, and compositions comprising one or more of said compound, may also be used in the treatment of keratitis, colon cancer (where biofilms play a role), and peri-implantitis, a bacterial infection around an implant that results in inflammation of the gums, and can lead to bone loss in the jaw.", "Certain strains of enterohaemorrhagic E. coli (EHEC) found in the gut of both animals and humans can cause disease, and can be life-threatening in a small group of patients that develop haemolytic uraemic syndrome (HUS).", "EHEC is not treated with antibiotics because of the risks of developing HUS.", "The compounds may be useful in the treatment of EHEC infections both in humans and animals, and particularly in cattle.", "Uropathogenic E. coli (UPEC) is the predominant etiologic agent that causes UTIs.", "Accordingly, the compositions can also be used to inhibit or reduce biofilm involved in lower urinary tract infections (UTIs).", "UTI's in human have been traditionally considered to be a self-limiting disease involving bacteria residing in the lumen of bladders.", "Intracellular bacterial community-like structures also have been identified in the urine sediments of patients with UTIs in a prospective study.", "In one embodiment, the biofilm that is inhibited or disrupted by the third aspect of the present invention may be a bacterial biofilm.", "The bacteria forming the biofilm may be gram positive, or in an alternative embodiment may be gram negative, or the biofilm may be formed by a mixture of gram positive and gram negative bacteria.", "Optionally, the biofilm may be formed by bacteria selected from the group consisting of S. epidermidis, E. faecalis, E. coli, S. aureus, H. pylori, Campylobacter, Enteropathogenic Escherichia coli (EPEC), Uropathogenic Escherichia coli (UPEC), and Pseudomonas or combinations thereof.", "Optionally, in certain embodiments of the third aspect of the present invention, the biofilm is a biofilm that is formed by bacteria other than bacteria that comprise, consist essentially of, or consist of proteobacteria class, such as any one or more of the spirilloid Wolinella spp., Helicobacter spp., and most particularly Campylobacter spp.", "Optionally, the one or more compounds administered to a subject (such as a human or animal) in accordance with the third aspect of the present invention may be a pharmaceutical or veterinary product, and further may include one or more excipients, such as discussed in section III.C of this application, below.", "In one embodiment of the third aspect of the present invention, for the treatment of biofilms in a subject (such as a human or animal), the one or more compounds is administered to a subject by one or more routes selected from: parenteral delivery, such as discussed below in section III.C.1 of this application, including a controlled release formulation, such as discussed below in section III.C.1(a) of this application, and injectable or implantable formulation, such as discussed below in section III.C.1(b) of this application; enteral delivery, such as discussed below in section III.C.2 of this application, including a controlled release enteral formulation, such as discussed below in section III.C.2(a) of this application, with further reference to extended release dosage forms and delayed release dosage forms as discussed therein; oral delivery; topical delivery, such as discussed below in section III.C.3 of this application, including as an emulsion, lotion, cream, ointment, gel, or foam as discussed in parts (a), (b), (c), (d) (e) and (f) respectively below in section III.C.3 of this application; buccal delivery; sublabial delivery; sublingual delivery; in or on a dental product, such as a toothpaste, a mouthwash, a dental floss, a mouth shield; dermal delivery; or transdermal delivery.", "In some embodiment of the third aspect of the present invention, the biofilm may be associated with a bacterial infection selected from the group consisting of impetigo, boils, abscesses, folliculitis, cellulitis, necrotizing fasciitis, pyomyositis, surgical/traumatic wound infection, and infected ulcers and burns), osteomyelitis, device-related osteoarticular infections, impetigo, secondarily infected skin lesions, meningitis, brain abscess, subdural empyema, spinal epidural abscess, arterial damage, gastritis, urinary tract infections, biliary tract infections, pyelonephritis, cystitis, sinus infections, ear infections, otitis media, otitis externa, leprosy, tuberculosis, conjunctivitis, bloodstream infections, benign prostatic hyperplasia, chronic prostatitis, lung infections including chronic lung infections of humans with cystic fibrosis, osteomyelitis, catheter infections, bloodstream infections, skin infections, acne, rosacea, dental caries, periodontitis, gingivitis, nosocomial infections, arterial damage, endocarditis, periprosthetic joint infections, open or chronic wound infections, venous stasis ulcers, diabetic ulcers, arterial leg ulcers, pressure ulcers, endocarditis, pneumonia, orthopedic prosthesis and orthopedic implant infections, peritoneal dialysis peritonitis, cirrhosis, and any other acute or chronic infection that involves or possesses a biofilm.", "A further embodiment of the third aspect of the present invention provides a method of treating a microbial infection in a subject in need thereof, the method comprising administering to the subject an effective amount of one or more compounds having the structure of Formula A or B, or other compounds of the invention of the present invention as described further in section III.A of this application.", "Likewise, this embodiment also provides for the use of one or more of said compounds for treating a microbial infection in a subject in need thereof.", "In certain embodiments, the microbial infection is caused by bacteria, such as gram positive bacteria, or gram negative bacteria.", "For example, the infection may be caused by bacteria selected from the group consisting of S. epidermidis, E. faecalis, E. coli, S. aureus, H. pylori, Campylobacter, Enteropathogenic Escherichia coli (EPEC), Uropathogenic Escherichia coli (UPEC), and Pseudomonas or combinations thereof and/or optionally wherein the infection is not caused by bacteria that comprise, consist essentially of, or consist of proteobacteria class, such as any one or more of the spirilloid Wolinella spp., Helicobacter spp., and most particularly Campylobacter spp.", "Optionally, in the treatment of a microbial infection in a subject in need thereof in accordance with this embodiment of the third aspect of the present invention, the one or more compounds may be administered to a subject by parenteral delivery; enteral delivery; oral delivery; topical delivery, such as in the form of an emulsion, lotion, cream, ointment, gel or foam; buccal delivery; sublabial delivery; sublingual delivery; in or on a dental product or dental device, such as a dental product, including but not limited to a toothpaste, a mouthwash, a dental floss, toothpicks, chewable products (including food products), a mouth shield, a dental instrument, dentures, dental retainers, dental braces including plastic braces (such as Invisalign), bristles of toothbrushes, dental prostheses and orthodontic devices, chewable non-food items, foods, or toys, such as dog bones and biscuits; dermal delivery; or transdermal delivery.", "In certain embodiments, the treatment of a microbial infection in a subject in need thereof in accordance with the this embodiment of the third aspect of the present invention may be to treat an infection is selected from the group consisting of impetigo, boils, abscesses, folliculitis, cellulitis, necrotizing fasciitis, pyomyositis, surgical/traumatic wound infection, and infected ulcers and burns), osteomyelitis, device-related osteoarticular infections, impetigo, secondarily infected skin lesions, meningitis, brain abscess, subdural empyema, spinal epidural abscess, arterial damage, gastritis, urinary tract infections, biliary tract infections, pyelonephritis, cystitis, sinus infections, ear infections, otitis media, otitis externa, leprosy, tuberculosis, conjunctivitis, bloodstream infections, benign prostatic hyperplasia, chronic prostatitis, lung infections including chronic lung infections of humans with cystic fibrosis, osteomyelitis, catheter infections, bloodstream infections, skin infections, acne, rosacea, dental caries, periodontitis, gingivitis, nosocomial infections, arterial damage, endocarditis, periprosthetic joint infections, open or chronic wound infections, venous stasis ulcers, diabetic ulcers, arterial leg ulcers, pressure ulcers, endocarditis, pneumonia, orthopedic prosthesis and orthopedic implant infections, peritoneal dialysis peritonitis, cirrhosis, and any other acute or chronic infection that involves or possesses a biofilm.", "In certain embodiments for the treatment of a microbial infection in a subject in need thereof in accordance with this embodiment of the third aspect of the present invention, the infection may be caused by a drug-resistant strain of E. coli.", "Optionally, the treatment of a microbial infection in a subject in need thereof in accordance with this embodiment of the third aspect of the present invention may be for the treatment of a urinary tract infection.", "Optionally, the treatment of a microbial infection in a subject in need thereof in accordance with this embodiment of the third aspect of the present invention, the subject may be one that is hospitalized and/or is immunocompromised.", "Optionally, the treatment of a microbial infection in a subject in need thereof in accordance with this embodiment of the third aspect of the present invention may also include further administering one or more antimicrobial agents, such as one or more antibiotics, to the subject.", "This may, for example, be conducted in accordance with any one or more of the embodiments of the second aspect of the present invention.", "III.", "Compounds and Compositions The present inventors have identified a class of a broad range of activity, particularly against bacteria, and has developed numerous uses for, and methods involving, the compounds, particularly in the formation of compositions.", "The compounds, which are further defined in Section III.A of this application, below, and compositions comprising one or more of said compounds, are presented herewith as a fourth aspect of the present invention.", "The compounds and compositions comprising one or more of the compounds can be used to inhibit or reduce biofilm formation on a surface, treat or prevent an infection, and kill some antibiotic resistant organisms.", "In one embodiment, the invention is generally directed to compounds and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for inhibiting, reducing, or preventing biofilm formation or buildup on a surface or to removing, dispersing, reducing, or eradicating biofilm on a surface.", "In another embodiment, the invention also generally relates to compounds and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments.", "In a further embodiment, the invention also relates to compounds and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for disinfecting surfaces, both in biological and non-biological environments, and products that have been coated with, or treated by, one or more of the compounds and/or compositions of the present invention.", "In another embodiment, the invention also relates to compounds and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for potentiating the effects of one or more antibiotics, increasing the sensitivity of bacteria (including antibiotic-resistant bacteria) to one or more antibiotics, and also to reversing antibiotic resistance in bacteria.", "In yet another embodiment, the invention also relates to compounds and compositions comprising one or more of the compounds, and methods and uses employing one or more of the compounds and/or compositions, for enhancing the growth of animals and their efficiency of feed utilization, in particular by oral administration of feed and drink compositions.", "A.", "Compounds The following compounds as described in this section of the application are provided herewith as a fourth aspect of the present invention.", "All other aspects of the present invention may utilize one or more types of compounds as defined in this section, including derivatives and salts as defined in sub-sections 1 and 2, respectively.", "Compositions comprising, consisting essentially of, or consisting of, one or more of these compounds is also provided as a further embodiment of the fourth aspect of the present invention.", "These compositions may be used in all of the other various aspects of the present invention, and methods and uses of the present invention which employ said compositions, and may comprise, consist essentially of, or consist of, one or more types of compound as defined in this section, including derivatives and salts as defined in sub-sections 1 and 2, respectively.", "Without limitation, compounds of particular interest for use in accordance with the present invention include Fe III complexes comprising ligands bound to the iron centre selected from amino acids or α-hydroxy acids, including but not limited to ferric quinate (also referred to herein interchangeable as FeQ and Fe-QA), ferric tyrosine (also referred to herein as FeTyr), ferric DOPA (also referred to herein as FeDOPA), and ferric phenylalanine (also referred to herein as Fe-Phe).", "Further, compounds which are structural and/or functional variants, derivatives and/or analogs of the foregoing compounds, as further described below in this section, are of particular interest to the present invention.", "The ligands that may be used in such complexes include ligands based on amino acids, α-hydroxy acids, o-hydroxy benzoic acids or pyridine-2-carboxylic acids.", "Exemplary amino acids can include, but are not limited to alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine, each preferably in the L-isoform although, as discussed above, in an alternative embodiment one or more (optionally all) may be in the D-isoform.", "Mixtures of optical isomers of the same amino acid may, or may not, be used in some embodiments.", "Exemplary α-hydroxy acids include, but are not limited to, quinic acid, lactic acid, glycolic acid, citric acid and mandelic acid.", "Exemplary o-hydroxy benzoic acids include, but are not limited to, salicylic acid.", "Exemplary pyridine-2-carboxylic acids include, but are not limited to, α-Picolinic acid.", "In certain embodiments, compounds for use in the present invention, and which may bind to MOMPs or FlaA of Campylobacter, are Fe III complexes each containing three bidentate ligands, such as described herein.", "In further embodiments, compounds for use in the present invention, and which may optionally bind to MOMPs or FlaA of Campylobacter, are Fe III complexes defined according to the following chemical Formula A: or a salt and/or hydrate thereof, wherein: X, X1 and X2 can independently be NH2, OH, CO2—, CO2H, OR3, NR3H, NR3R4, R3ONO2, R3NO2, SH, SR3, and X, X1 and X2 may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; Y, Y1 and Y2 can independently be O, NH, NH2, NR3, NR3R4, SH, OR3, OH, and Y, Y1 and Y2 may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; Z, Z1 and Z2 may independently be: O, S, NH, NR3, and Z, Z1 and Z2 may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; R, R′, R1, R1′, R2, and R2′ can independently be H, CH3, CH2SH, CH2CO2H, CH2CH2CO2H, CH2C6H5, CH2C3H3N2, CH(CH3)CH2CH3, (CH2)4NH2, CH2CH(CH3)2, CH2CH2SCH3, CH2CONH2, (CH2)4NHCOC4H5NCH3, CH2CH2CH2, CH2CH2CONH2, (CH2)3NHC(NH)NH2, CH2OH, CH(OH)CH3, CH2SeH, CH(CH3)2, CH2C8H6N, CH2C6H4OH and R, R′, R1, R1′, R2, and R2′ may all be the same or they may all be different, or, alternatively, up to five may be the same and one or more may be different; or any relevant pair of R and R′, R1 and R1′, and R2 and R2′ (i.e.", "when they are bound to the same carbon atom) are linked to form a substituted or unsubstituted cycloalkyl ring group; R3 and R4 can independently be alkyl, alkenyl, alkynyl, phenyl, aryl, halo- and hydroxy-substituted radicals, hydroxyl radicals, nitrogen-substituted radicals, oxygen-substituted radicals, or hydrogen.", "In some embodiments, R3 and R4 may all be the same or they may all be different, or, alternatively, two may be the same and one may be different.", "In embodiments in which one or more pairs of R and R′, R1 and R1′, and R2 and R2′ are linked to form a substituted or unsubstituted cycloalkyl ring group, the substituents on the cycloalkyl group can be selected from, but are not limited to, ═O and, particularly, OH, NH2, NR3, NR3R4, SH, and OR3; where R3 and R4 are as defined above.", "It is preferred that the bonds between the Fe and X, X1 and X2 and between the Fe and Y1 and Y2 are ionic.", "In a particular embodiment, X, X1 and X2 can independently be NH2, OH, CO2—, CO2H, OR3, NR3H or NR3R4 (preferably NH2 or OH); Y, Y1 and Y2 can independently be O, NH, NH2, OR3 or OH (preferably O); Z, Z1 and Z2 may independently be O or S (preferably O); R, R′, R1, R1′, R2, and R2′ can independently be H, CH3, CH2SH, CH2CO2H, CH2CH2CO2H, CH2C6H5, CH2C3H3N2, CH(CH3)CH2CH3, (CH2)4NH2, CH2CH(CH3)2, CH2CH2SCH3, CH2CONH2, (CH2)4NHCOC4H5NCH3, CH2CH2CH2, CH2CH2CONH2, (CH2)3NHC(NH)NH2, CH2OH, CH(OH)CH3, CH2SeH, CH(CH3)2, CH2C8H6N, CH2C6H4OH; or any relevant pair of R and R′, R1 and R1′, and R2 and R2′ are linked to form a 4- to 6-membered substituted or unsubstituted cycloalkyl ring group (optionally wherein the substituents on the cycloalkyl group are selected from ═O and, particularly, OH, NH2, NHR3, NR3R4, SH, and OR3); and R3 and R4 independently represent methyl, ethyl, propyl, butyl, or benzyl.", "Particular compounds that may be mentioned include those in which R′, R1′ and R2′ represent H, and R, R1 and R2 represent a group as defined above other than H; or each pair of R and R′, R1 and R1′, and R2 and R2′ (i.e.", "when they are bound to the same carbon atom) are linked to form a cyclohexyl ring group optionally substituted one or more substituents selected from ═O and, particularly, OH, NH2, NHR3, NR3R4, SH, and OR3.In a further embodiment, R3 and R4 are independently C1-4 alkyl, C1-4 alkenyl, phenyl or benzyl (which latter four groups are optionally substituted by one or more halo or hydroxyl groups).", "For example, R3 and R4 may independently represent methyl, ethyl, propyl, butyl or benzyl.", "In a preferred embodiment, Y, Y1 and Y2 represent O, and Z, Z1 and Z2 represent O.", "Particular examples of such compounds include those in which X, X1 and X2 independently represent NH2 or OH.", "Functional variants of compounds according to Formula A may also be used in the present invention, and include other compounds as described in this section of the application.", "For example, in a yet further embodiment, compounds for use in the present invention, and which may bind to MOMPs or FlaA of Campylobacter, are Fe III complexes defined according to the following chemical Formula B: or a salt and/or hydrate thereof, wherein: X3, X4 and X5 can independently be —C(R8)═, or —N═; R8 can independently be NH2, OH, CO2—, CO2H, OR9, NR9H, NR9R10, R9ONO2, R9NO2, SH, SR9, and each R8 may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; Y3, Y4 and Y5 can independently be O, NH, NH2, NR9, NR9R10, SH, OR9, OH, and Y3, Y4 and Y5 may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; Z3, Z4 and Z5 may independently be: O, S, NH, NR9, and Z3, Z4 and Z5 may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; m1, m2 and m3 may independently be 0, 1, 2, 3 or 4; and m1, m2 and m3 may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; R5, R6 and R7 are each independently selected from OH, NH2, NHR9, NR9R10, SH, and OR9; and R5, R6 and R7 may all be the same or they may all be different; R9 and R10 can independently be alkyl, alkenyl, alkynyl, phenyl, aryl, halo- and hydroxy-substituted radicals, hydroxyl radicals, nitrogen-substituted radicals, oxygen-substituted radicals, or hydrogen.", "In some embodiments, R9 and R10 may all be the same or they may all be different.", "It is preferred that the bonds between the Fe and X3, X4 and X5 and between the Fe and Y3, Y4 and Y5 are ionic.", "In a particular embodiment, X3, X4 and X5 can independently be —C(OH)═, or —N═; Y3, Y4 and Y5 can independently be O, NH, NH2, OR9 or OH (preferably O); Z, Z1 and Z2 may independently be O or S (preferably O); R5, R6 and R7 are each independently selected from OH, NH2, NHR9, and OR9 (preferably R5, R6 and R7 are all OH); m1, m2 and m3 may independently be selected from 0, 1 and 2; and R9 and R10 independently represent methyl, ethyl, propyl, butyl, or benzyl.", "In a further embodiment, R9 and R10 are independently C1-4 alkyl, C1-4 alkenyl, phenyl or benzyl (which latter four groups are optionally substituted by one or more halo or hydroxyl groups).", "For example, R3 and R4 may independently represent methyl, ethyl, propyl, butyl or benzyl.", "In a preferred embodiment, Y3, Y4 and Y5 represent O, Z3, Z4 and Z5 represent O, R5, R6 and R7 represent OH, and m1, m2 and m3 are selected from 0, 1 and 2.Particular examples of such compounds include those in which X3, X4 and X5 independently represent —C(OH)═ or —N═.", "In a further preferred embodiment, the ligands bound to the iron centre are amino acids or α-hydroxy acids.", "Therefore, it is most preferred that Y, Y1, Y2, Z, Z1 and Z2 represent O, X, X1 and X2 represent NH2 or OH, and R′, R1′ and R2′ represent H. Where one or more of the ligands is an amino acid (e.g.", "for compounds of formula A in which X, X1 and X2 represent NH2), then it is preferred that the amino acid is an L-amino acid (or glycine), although in an alternative embodiment one or more (optionally all) of the ligands may be a D-amino acid.", "Exemplary amino acids can include, but are not limited to alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine, each preferably in the L-isoform although, as discussed above, in an alternative embodiment one or more (optionally all) may be in the D-isoform.", "Mixtures of optical isomers of the same amino acid may, or may not, be used in some embodiments.", "Exemplary compounds of Fe complexes according to Formula A include Formulas VII-IX as shown below: g) a complex of L-DOPA with Fe III (3,4 dihydrophenylalanine) (Fe-DOPA) h) a complex of L-tyrosine with Fe III (Fe-Tyr, also denoted Fe-Y) i) a complex of quinic acid with Fe III (Fe-QA, also denoted FeQ) Exemplary compounds of Fe complexes according to Formula B include Formulas X-XIV as shown below: j) a complex of 2,3,5-trihydroxybenzoic acid with Fe III k) a complex of 2,4,5-trihydroxybenzoic acid with Fe l) a complex of 3-dehydroquinic acid with Fe III m) a complex of 4,6-dihydroxypyridine-2-carboxylic acid with Fe III n) a complex of salicylic acid with Fe III Optionally, in one embodiment, an Fe complex as described above (e.g.", "according to Formula A or Formula B) for use in any of the first, second or third aspects of the present invention may not be a complex of quinic acid with Fe III (such as a complex having the structure of Formula IX).", "That is to say, in one optional embodiment, Formula A excludes a complex of quinic acid with Fe III (such as a complex having the structure of Formula IX).", "In a further embodiment, a compound according to Formula A, or Formula B, for use in the present invention may be a compound that inhibits the binding of C. jejuni to a histo-blood group antigen.", "This can, for example, be measured when the bacteria is grown in a medium containing the compound, the medium containing the compound is washed away, and the binding of the bacteria to the histo-blood group antigen is determined by an ELISA assay (such as in accordance with the method as described in Example 4) and compared to a control where the bacteria is not grown in the presence of the compound.", "Preferably the compound inhibits the binding of C. jejuni to a histo-blood group antigen at a level that is at, or at least, about 1%, 2%, 3%, 4%, more preferably at, or at least, about 5%, even more preferably at, or at least, about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99%, 100% or more than the level of inhibition of the binding of C. jejuni to a histo-blood group antigen by either a complex of L-tyrosine with Fe III or a complex of quinic acid with Fe III at the same molar concentration.", "In a further embodiment, a compound according to Formula A, or Formula B, for use in the present invention may be a compound that inhibits biofilm formation by bacteria as measured in a plastic bead assay (such as in accordance with a method as described in Example 1), wherein the bacteria is grown in a medium containing the compound to form a growth suspension of the bacteria at 0.0001 OD/ml, the growth suspension is allowed to grow with plastic coated UV beads (Lascells), and the beads are assayed after 24 hours for the presence of biofilm formation on the beads (by counting bacteria after release from the beads), and compared to a control group where the bacteria is not grown in the presence of the compound.", "Preferably the compound inhibits the binding of the bacteria to the plastic coated beads at a level of inhibition that is at, or at least, about 1%, 2%, 3%, 4%, more preferably at, or at least, about 5%, even more preferably at, or at least, about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99%, 100% or more of the level of inhibition of the binding of the bacteria to the plastic coated UV beads by either a complex of L-tyrosine with Fe III or a complex of quinic acid with Fe III at the same molar concentration.", "In particularly preferred embodiment, the bacteria can be Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus, Campylobacter jejuni, Pseudomonas aeruginosa, Uropathogenic Escherichia coli, and Enteropathogenic Escherichia coli.", "In a further embodiment, a compound according to Formula A, or Formula B, for use in the present invention may be a compound that inhibits binding of Helicobacter pylori to human gastric tissue (for example as determined by a method as described in Example 5) at a level of inhibition that is at, or at least, about 1%, 2%, 3%, 4%, more preferably at, or at least, about 5%, even more preferably at, or at least, about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99%, 100% or more of the level of inhibition of the binding of the bacteria to human gastric tissue by either a complex of L-tyrosine with Fe III or a complex of quinic acid with Fe III at the same molar concentration as measured by counting the average number of bacteria bound to the tissue.", "In a further embodiment, a compound according to Formula A, or Formula B, for use in the present invention may be a compound that inhibits biofilm formation of a bacteria, but does not inhibit planktonic growth of the bacteria (for example, as determined using a method as described in Example 7), wherein the bacteria can be one or more of the following: Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus, Campylobacter jejuni, Pseudomonas aeruginosa, Uropathogenic Escherichia coli, and Enteropathogenic Escherichia coli.", "Preferably the compounds inhibit biofilm formation (for example, as measured by coverage rate in Example 7), at a level that is at, or at least, about 1%, 2%, 3%, 4%, more preferably at, or at least, about 5%, even more preferably at, or at least, about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99%, 100% or more of the level of biofilm inhibition by a complex of L-tyrosine with Fe III or a complex of quinic acid with Fe III at the same molar concentration.", "In a further embodiment, a compound according to Formula A, or Formula B, for use in the present invention may be a compound for the treatment of cystic fibrosis.", "In one embodiment, one or more compounds of Formula A may be delivered using a nebulizer spray.", "In another embodiment, one or more compounds of Formula A may be delivered in liposomes for the treatment of patients with cystic fibrosis.", "In a further embodiment, a compound according to Formula A, or Formula B, for use in the present invention may be a compound that prevents attachment of bacteria to a surface (for example, when determined in accordance with a method as described in Example 13), and the prevention of attachment of bacteria to the surface is at a level that is at, or at least, about 1%, 2%, 3%, 4%, more preferably at, or at least, about 5%, even more preferably at, or at least, about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99%, 100% or more of the level of bacteria attachment by a complex of L-tyrosine with Fe III or a complex of quinic acid with Fe III at the same molar concentration as measured by optical density.", "In particularly preferred embodiment, the bacteria can be Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus, Campylobacter jejuni, Pseudomonas aeruginosa, Uropathogenic Escherichia coli, and Enteropathogenic Escherichia coli.", "In a further embodiment, a compound according to Formula A, or Formula B, for use in the present invention may be a compound that is capable of rendering an antibiotic resistant strain of bacteria sensitive to the antibiotic to which it is otherwise resistant (for example, when determined by a method that comprises immersing a patch in a solution of the compound and an antibiotic, such as kanamycin, for example at a concentration of 50 μg/mL as described in Example 9, placed on a plate with the antibiotic resistant strain (such as a kanamycin resistant strain of Enteropathogenic Escherichia coli or Campylobacter jejuni)), and causes the bacteria to fail to grow or reduces the rate of growth of the antibiotic resistant strain in the presence of the antibiotic by a level that is a level that is at, or at least, about 1%, 2%, 3%, 4%, more preferably at, or at least, about 5%, even more preferably at, or at least, about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99%, 100% or more of the level of reduction of the rate of growth caused by a complex of L-tyrosine with Fe III or a complex of quinic acid with Fe III at the same molar concentration.", "In a further embodiment, a compound according to Formula A, or Formula B, for use in the present invention may be a compound that causes a decrease in the rate of growth to a level that is at, or at least, about 1%, 2%, 3%, 4%, more preferably at, or at least, about 5%, even more preferably at, or at least, about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99%, 100% or more of the decrease in the rate of growth measured by optical density of an antibiotic resistant bacteria when grow in the presence of the compound and the antibiotic, for example as determined by a method as described in Examples 11 and/or 12.The combinations of antibiotics and antibiotic resistant bacteria can, for example, be one or more of the following: (i) kanamycin and a kanamycin-resistant bacteria, (ii) gentamicin and a gentamicin-resistant enteropathogenic Escherichia coli, and (iii) kanamycin and a clinical isolate of Pseudomonas (PAO Clinical) as described in Example 14.In accordance with one embodiment, instead of the direct administration of the one or more compounds, it or they may be formed in vivo, by administering a suitable iron containing substance and one or more suitable ligands capable of forming the compounds in vivo with the iron compound (see: Campbell and Hasinoff, Ferrous sulfate reduces levodopa bioavailability: Chelation as a possible mechanism, Clin.", "Pharmacol.", "Ther.", "45:220-5, 1989).", "For example, ferrous sulfate and tyrosine (as ligand) may be administered in order to form Fe-Tyr in vivo, ferrous sulfate and L-DOPA (as ligand) may be administered in order to form Fe-DOPA in vivo, ferrous sulfate and L-phenylalanine (as ligand) may be administered in order to form Fe-Phe in vivo or ferrous sulfate and quinic acid (as ligand) may be administered in order to from Fe-QA in vivo.", "In this example, Fe2+ is oxidized to Fe3+ in vivo, and may complex with tyrosine, L-DOPA, or phenylalanine respectively.", "The compounds may also be formed in vivo from any substance that can be metabolized in vivo to the compounds.", "For example, phenylalanine could be administered with ferrous sulfate since it will be metabolized to tyrosine in vivo, and may then complex with the ferric iron (formed from oxidation of ferrous sulfate).", "Alternatively, ferric chloride could also be administered with, for example, tyrosine, quinic acid, L-DOPA and/or phenylalanine.", "Optionally, one or more compounds for use in any of the first, second or third aspects of the present invention (which may or may not be compounds according to Formula A or Formula B as discussed above) are ligands for the major outer membrane proteins (MOMPs) or FlaA of Campylobacter, and/or may be capable of downregulating the expression of FlaA and/or FlaB proteins in a bacteria such as Campylobacter, such as to the extent of causing a reduced bacterial motility such as when determined by a method as described in Example 21 of the present application.", "The binding of the compounds to the MOMPs or FlaA inhibits the MOMPs or FlaA from attaching, binding, or associating with other proteins, biofilm components, surfaces or other bacteria.", "The compound can be a mimetic or synthetic human histo-blood group antigen or a synthetic sugar.", "A synthetic human histo-blood group antigen may be a sugar, for example a saccharide having the same structure as a natural human histo-blood group antigen such as for example H-I antigen, H-II antigen, Lewis antigen, Leb, Lex or Ley.", "A preferred compound is ferric quinate (Fe-QA).", "The compounds provided herein which bind to MOMPs or FlaA of Campylobacter include compounds with structures described in this section, in accordance with Formulae A or B, or further compounds as described below.", "It has been demonstrated that these compounds inhibit both gram negative bacteria, such as Pseudomonas aeruginosa, Campylobacter jejuni, Helicobacter pylori, Escherichia coli, Enteropathogenic Escherichia coli (EPEC), Uropathogenic Escherichia coli (UPEC) and gram positive bacteria, such as Staphylococcus epidermidis, Staphylococcus aureus, and Enterococcus faecalis, which are believed to be predictive of efficacy with other species There is low homology between the MOMP of Campylobacter and other bacteria.", "It is believed that the compounds interact with several surface porin-like bacterial proteins that have not yet been identified on other bacteria.", "In further embodiments, compounds for use in the present invention may, or may not, optionally include one or more compounds selected from: a) N-[3-quinylamino-2-(quinylaminomethyl)-propyl]-quinamde b) N-{2-[Bis-(2-quinylaminoethyl)-amino]-ethyl}-quinamide c) Phosphoric acid tris-(2-quinylamino-ethyl) ester d) N-(3,5-Bis-quinylamino-cyclohexyl)-quinamide e) N-(4,5-Bis-quinylamino-2-hydroxy-6-hydroxymethyl-tetrahydropyran-3-yl)-quinamide f) N-(4,5-Bis-quinylamino-2-hydroxy-6-quinylaminomethyl-tetrahydropyran-3-yl)-quinamide The foregoing compounds for use in any of the aspects of the present invention may also be in the form of hydrates, or salts of hydrates.", "For example, the compositions may be Fe-Tyr.xH2O, FeQ.xH2O, FeDOPA.xH2O or Fe-Phe.xH2O.", "The compounds may also be hydrates containing salts, for example hydrates with bases such as lithium hydroxide, sodium hydroxide or potassium hydroxide present.", "In the case of compounds which are Fe III complexes comprising ligands bound to the iron centre, as described above, in one option not all ligands will be the same in the compositions comprising the Fe III complex compounds.", "For example, in the case that the compound is FeTyr, then this may be formed by creating a complex from Fe III and a commercial source of tyrosine (Tyr), which may include low levels (typically, less than 10%, such as less than 5% or about 2.5%) of one or more further amino acids, such as cysteine (Cys) and/or phenylalanine (Phe), and so in one optional embodiment, when the compound is FeTyr, then some of the compounds in the composition may include one or more alternative amino acids (e.g.", "Cys and/or Phe) as ligands.", "The proportion of ligands in the FeTyr composition that are not Tyr may be less than 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2% or 1% and may be substantially 0%.", "The same applies mutatis mutandis to other ligands used in the preparation of Fe III complexes for use in the present invention.", "Therefore, for example, in a composition comprising an Fe III complex as described above, it may be that less than 100% of the Fe III ligands are identical, although preferably at least 50%, 60%, 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% of the ligands in the composition are identical.", "In that context, in one embodiment the term “identical” discriminates between enantiomeric forms of ligand, that is, different enantiomers are not identical; whereas, in another embodiment, the term “identical” can be applied to different enantiomeric forms of ligand, that is, optionally different enantiomeric forms of the same ligand are considered to be identical.", "1.Derivatives Derivatives of the compounds for use in accordance with any of the aspects of the present invention, such as the compounds defined above, including Formula I-IX, Formula X to XIV, Formula A (or hydrates thereof) and Formula B or hydrates thereof), may also be used.", "The term “derivative” does not mean that the derivative is synthesized from the parent compound either as a starting material or intermediate, although this may be the case.", "The term “derivative” can include salts (for example, pharmaceutically acceptable salts), prodrugs, or metabolites of the parent compound.", "Derivatives include compounds in which free amino groups in the parent compound have been derivatized to form amine hydrochlorides, p-toluene sulfoamides, benzoxycarboamides, t-butyloxycarboamides, thiourethane-type derivatives, trifluoroacetylamides, chloroacetylamides, or formamides.", "Derivatives include compounds having one or more amino substituents or hydrogen groups replaced with substituted or unsubstituted alkyl, aminoalkyl, aryl, or heteroaryl groups having from 1 to 30 carbon atoms.", "2.Salts The compounds for use in accordance with any of the aspects of the present invention, such as the compounds defined above, including of Formula I-IX, Formula X to XIV, Formula A (or hydrates thereof) and Formula B or hydrates thereof) can be in the form of a salt, for example, a pharmaceutically acceptable salt.", "Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; and alkali or organic salts of acidic residues such as carboxylic acids.", "The pharmaceutically acceptable salts include the conventional non-toxic salts or the quaternary ammonium salts of the parent compound formed, for example, from non-toxic inorganic or organic acids and inorganic or organic bases.", "Such conventional non-toxic salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, and nitric acids; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, pamoic, maleic, hydroxymaleic, phenylacetic, glutamic, benzoic, salicylic, sulfanilic, 2-acetoxybenzoic, fumaric, tolunesulfonic, naphthalenesulfonic, methanesulfonic, ethane disulfonic, oxalic, and isethionic salts, and bases such as lithium hydroxide, sodium hydroxide, potassium hydroxide and ammonium hydroxide.", "The pharmaceutically acceptable salts of the compounds can be synthesized from the parent compound, which contains a basic or acidic moiety, by conventional chemical methods.", "Generally, such salts can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, non-aqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred.", "Lists of suitable salts are found in Remington's Pharmaceutical Sciences, 20th ed., Lippincott Williams & Wilkins, Baltimore, Md., 2000, p. 704; and “Handbook of Pharmaceutical Salts: Properties, Selection, and Use,” P. Heinrich Stahl and Camille G. Wermuth, Eds., Wiley-VCH, Weinheim, 2002.B.", "Antimicrobial Agents Antimicrobial agents that may be used therapeutically and/or non-therapeutically with the compounds of the present invention in accordance with any of the first, second, or third aspects of the present invention, for example for the treatment or prophylaxis of microbial infection in accordance with the third aspect of the present invention and/or in accordance with the second aspect of the present invention, either separately, simultaneously or sequentially, include, but are not limited to: (i) Aminoglycosides, including amikacin, gentamicin, kanamycin, neomycin, netilmicin, tobramycin, paromomycin, streptomycin, spectinomycin; (ii) Ansaycins, including geldanamycin, herbimycin, rifaximin, (iii) Carbacephem, including loracarbef, (iv) Carbapenems, including ertapenem, doripenem, imipenem/cilastatin, meropenem, (v) Cephalosporins, including cefadroxil, cefazolin, cefalotin or cefalothin, cephalexin, cefaclor, cefamandole, cefoxitin, cefprozil, cefuroxime, cefixime, cefdinir, cefditoren, cefoperazone, cefotaxime, cefpodoxime, ceftazidime, ceftibuten, ceftizoxime, ceftriaxone, cefepime, ceftaroline fosamil, ceftobiprole, (vi) Glycopeptides, including teicoplanin, vancomycin, telavancin, dalbavancin, oritavancin, (vii) Lincosamides, including clindamycin, lincomycin, (viii) Lipopeptides including daptomycin, (ix) Macrolides including azithromycin, clarithromycin, dirithromycin, erythromycin, roxithromycin, troleandomycin, telithromycin, spiramyin, (x) Monobactams, including aztreonam, (xi) Nitrofurans, including furazolidone, nitrofurantoin, (xii) Oxazolidinones, including linezolid, posizolid, radezolid, torezolid, (xiii) Penicillins, including amoxicillin, ampicillin, azlocillin, carbenicillin, cloxacillin, dicloxacillin, flucloxacillin, mezlocillin, methicillin, nafcillin, oxacillin, penicillin G, penicillin V, piperacillin, temocillin, ticarcillin, amoxicillin/clavulanate, ampicillin/sulbactam, peperacillin/tazobactam, ticarcillin/clavulanate (xiv) Polypeptides including bacitracin, colistin, polymyxin B, (xv) Quinolones/Fluoroquinolone, including ciprofloxacin, enoxacin, gatifloxacin, gemifloxacin, levofloxacin, lomefloxacin, moxifloxacin, nalidixic acid, norfloxacin, ofloxacin, trovafloxacin, grepafloxacin, sparfloxacin, temafloxacin, (xvi) Sulfonamides, including mafenide, sulfacetamide, sulfadiazine, silver sulfadiazine, sulfadimethoxine, sulfamethizole, sulfamethoxazole, sulfanilamide, sulfasalazine, sulfisoxazole, trimethoprim-sulfamethoxazole (co-trimoxazaole), sulfonamidochrysoidine, (xvii) Tetracyclines, including demeclocycline, doxycycline, minocycline, oxytetracycline, tetracycline, (xviii) clofazimine, dapsone, capreomycin, cycloserine, ethambutol, ethionamide, isoniazid, pyrazinamide, rifampicin (rifampin), rifabutin, rifapentine, streptomycin, arsphenamine, chloramphenicol, fosfomycin, fusidic acid, metronidazole, mupirocin, platensimycin, quinupristin/dalfopristin, thiamphenicol, tigecycline, tinidazole, and trimethoprim; and combinations thereof.", "The compounds may also be combined with triclosan and chlorhexidine.", "Other antimicrobial agents include: aztreonam; cefotetan and its disodium salt; loracarbef; cefoxitin and its sodium salt; cefazolin and its sodium salt; cefaclor; ceftibuten and its sodium salt; ceftizoxime; ceftizoxime sodium salt; cefoperazone and its sodium salt; cefuroxime and its sodium salt; cefuroxime axetil; cefprozil; ceftazidime; cefotaxime and its sodium salt; cefadroxil; ceftazidime and its sodium salt; cephalexin; cefamandole nafate; cefepime and its hydrochloride, sulfate, and phosphate salt; cefdinir and its sodium salt; ceftriaxone and its sodium salt; cefixime and its sodium salt; cefpodoxime proxetil; meropenem and its sodium salt; imipenem and its sodium salt; cilastatin and its sodium salt; azithromycin; clarithromycin; dirithromycin; erythromycin and hydrochloride, sulfate, or phosphate salts, ethylsuccinate, and stearate forms thereof, clindamycin; clindamycin hydrochloride, sulfate, or phosphate salt; lincomycin and hydrochloride, sulfate, or phosphate salt thereof, tobramycin and its hydrochloride, sulfate, or phosphate salt; streptomycin and its hydrochloride, sulfate, or phosphate salt; neomycin and its hydrochloride, sulfate, or phosphate salt; acetyl sulfisoxazole; colistimethate and its sodium salt; quinupristin; dalfopristin; amoxicillin; ampicillin and its sodium salt; clavulanic acid and its sodium or potassium salt; penicillin G; penicillin G benzathine, or procaine salt; penicillin G sodium or potassium salt; carbenicillin and its disodium or indanyl disodium salt; piperacillin and its sodium salt; ticarcillin and its disodium salt; sulbactam and its sodium salt; moxifloxacin; ciprofloxacin; ofloxacin; levofloxacins; norfloxacin; gatifloxacin; trovafloxacin mesylate; alatrofloxacin mesylate; trimethoprim; sulfamethoxazole; demeclocycline and its hydrochloride, sulfate, or phosphate salt; doxycycline and its hydrochloride, sulfate, or phosphate salt; oxytetracycline and its hydrochloride, sulfate, or phosphate salt; chlortetracycline and its hydrochloride, sulfate, or phosphate salt; metronidazole; dapsone; atovaquone; rifabutin; linezolide; polymyxin B and its hydrochloride, sulfate, or phosphate salt; sulfacetamide and its sodium salt; clarithromycin; and silver ions, salts, and complexes.", "One preferred embodiment of any of the aspects of the present invention, such as in accordance with the second aspect of the present invention, envisages the use of a complex of quinic acid with Fe III (Fe-QA, also denoted FeQ), such as defined by Formula IX, with any one or more of the foregoing antibiotics, either formulated together in the same composition for administration or presented in separate compositions for use separately, simultaneously or sequentially.", "Another preferred embodiment, of any of the aspects of the present invention, such as in accordance with the second aspect of the present invention, envisages the use of a complex of L-tyrosine with Fe III (Fe-Tyr), such as defined by Formula VIII, with any one or more of the foregoing antibiotics, either formulated together in the same composition for administration or presented in separate compositions for use separately, simultaneously or sequentially.", "In another preferred embodiment, of any of the aspects of the present invention, such as in accordance with the second aspect of the present invention, envisages the use of a complex of L-DOPA with Fe III (3,4 dihydrophenylalanine) (Fe-DOPA), such as defined by Formula VII, with any one or more of the foregoing antibiotics, either formulated together in the same composition for administration or presented in separate compositions for use separately, simultaneously or sequentially.", "In another preferred embodiment, of any of the aspects of the present invention, such as in accordance with the second aspect of the present invention, envisages the use of a complex of L-phenylalanine with Fe III (Fe-Phe), with any one or more of the foregoing antibiotics, either formulated together in the same composition for administration or presented in separate compositions for use separately, simultaneously or sequentially.", "C. Excipients and Carriers The compounds as defined in section III.A above can be formulated for use in accordance with any of the first, second or third aspect of the present invention and may, for example, be formulated in a way that is suitable for enteral, parenteral, topical, or pulmonary administration.", "The compounds as defined in section III.A above can be combined with one or more pharmaceutically acceptable carriers and/or excipients that are considered safe and effective and may be administered to an individual without causing undesirable biological side effects or unwanted interactions.", "The carrier can include all components present in the pharmaceutical formulation other than the active ingredient or ingredients.", "The compounds are included in the formulation in an effective amount to achieve the effect of the first, second or third aspects of the present invention, for example in an amount that is effective to inhibit biofilm formation or reduce biofilm buildup.", "An effective amount of a compound provided to a subject may be an amount that is enough to provide the required degree of reduction of microbial colonization.", "This may depend on the type of compound and/or the size of the animal.", "In one embodiment an effective amount of the compound may be an amount that is effective to deliver the compound to the site at which action is required in a concentration that ranges from 1 μm to 1 M, preferably greater than 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 90 μM, 100 μM, 110 μM, 120 μM, 130 μM, 140 μM, 150 μM, 160 μM, 170 μM, 180 μM, 190 μM, 200 μM or more.", "A suitable concentration may be within the range of about 1 μm to about 1 mM, or about 30 μm to about 0.5 mM, or about 60 μM to about 0.3 mM.", "These concentrations may particularly apply to the performance of the invention in the context of the second and/or third aspects of the present invention.", "In a further embodiment an effective amount of the compound may be 0.3 to 32 mg/day/kg bodyweight of the subject such as a chicken.", "In another embodiment an effective concentration of the compound may be between 0.001 to 1 mM for use in coatings or devices, or solutions.", "The compounds can also be formulated for use as a disinfectant, for example, in a hospital environment or for industrial application.", "1.Parenteral Formulations The compounds as defined in section III.A above for use in accordance with any of the first, second or third aspect of the present invention and may be formulated for parenteral administration.", "Parenteral administration may include administration to a patient intravenously, intradermally, intraarterially, intraperitoneally, intralesionally, intracranially, intraarticularly, intraprostatically, intrapleurally, intratracheally, intravitreally, intratumorally, intramuscularly, subcutaneously, subconjunctivally, intravesicularly, intrapericardially, intraumbilically, by injection, and by infusion.", "Parenteral formulations can be prepared as aqueous compositions using techniques known in the art.", "Typically, such compositions can be prepared as injectable formulations, for example, solutions or suspensions; solid forms suitable for using to prepare solutions or suspensions upon the addition of a reconstitution medium prior to injection; emulsions, such as water-in-oil (w/o) emulsions, oil-in-water (o/w) emulsions, and microemulsions thereof, liposomes, or emulsomes.", "The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, one or more polyols (e.g., glycerol, propylene glycol, and liquid polyethylene glycol), oils, such as vegetable oils (e.g., peanut oil, corn oil, sesame oil, etc.", "), and combinations thereof.", "The proper fluidity can be maintained, for example, by the use of a coating, such as lecithin, by the maintenance of the required particle size in the case of dispersion and/or by the use of surfactants.", "In many cases, it will be preferable to include isotonic agents, for example, sugars or sodium chloride.", "Solutions and dispersions of the active compounds as the free acid or base or pharmacologically acceptable salts thereof can be prepared in water or another solvent or dispersing medium suitably mixed with one or more pharmaceutically acceptable excipients including, but not limited to, surfactants, dispersants, emulsifiers, pH modifying agents, viscosity modifying agents, and combination thereof.", "Suitable surfactants may be anionic, cationic, amphoteric or nonionic surface-active agents.", "Suitable anionic surfactants include, but are not limited to, those containing carboxylate, sulfonate and sulfate ions.", "Examples of anionic surfactants include sodium, potassium, ammonium ions of long chain alkyl sulfonates and alkyl aryl sulfonates such as sodium dodecylbenzene sulfonate; dialkyl sodium sulfosuccinates, such as sodium dodecylbenzene sulfonate; dialkyl sodium sulfosuccinates, such as sodium bis-(2-ethylthioxyl)-sulfosuccinate; and alkyl sulfates such as sodium lauryl sulfate.", "Cationic surfactants include, but are not limited to, quaternary ammonium compounds such as benzalkonium chloride, benzethonium chloride, cetrimonium bromide, stearyl dimethylbenzyl ammonium chloride, polyoxyethylene and coconut amine Examples of nonionic surfactants include ethylene glycol monostearate, propylene glycol myristate, glyceryl monostearate, glyceryl stearate, polyglyceryl-4-oleate, sorbitan acylate, sucrose acylate, PEG-150 laurate, PEG-400 monolaurate, polyoxyethylene monolaurate, polysorbates, polyoxyethylene octylphenylether, PEG-1000 cetyl ether, polyoxyethylene tridecyl ether, polypropylene glycol butyl ether, Poloxamer® (triblock copolymer of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene) 401, stearoyl monoisopropanolamide, and polyoxyethylene hydrogenated tallow amide.", "Examples of amphoteric surfactants include sodium N-dodecyl-.beta.-alanine, sodium N-lauryl-β-iminodipropionate, myristoamphoacetate, lauryl betaine and lauryl sulfobetaine.", "The formulation can contain a preservative to prevent the growth of microorganisms.", "Suitable preservatives include, but are not limited to, parabens, chlorobutanol, phenol, sorbic acid, and thimerosal.", "The formulation may also contain an antioxidant to prevent degradation of the active agent(s).", "The formulation is typically buffered to a pH of 3-8 for parenteral administration upon reconstitution.", "Suitable buffers include, but are not limited to, phosphate buffers, acetate buffers, and citrate buffers.", "It is to be noted that FeQ and some of the other compounds as defined in Section III.A of the application are acidic, and so advantageously are formulated with a buffer in order to achieve a suitable pH, particularly in the context of preparing injectable formulation, including formulations for intravenous injection.", "Water-soluble polymers are often used in formulations for parenteral administration.", "Suitable water-soluble polymers include, but are not limited to, polyvinylpyrrolidone, dextran, carboxymethylcellulose, and polyethylene glycol.", "Sterile injectable solutions can be prepared by incorporating the active compounds in the required amount in the appropriate solvent or dispersion medium with one or more of the excipients listed above, as required, followed by filtered sterilization.", "Generally, dispersions are prepared by incorporating the various sterilized active ingredients into a sterile vehicle which contains the basic dispersion medium and the required other ingredients from those listed above.", "In the case of sterile powders for the preparation of sterile injectable solutions, the preferred methods of preparation are vacuum-drying and freeze-drying techniques which yield a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof.", "The powders can be prepared in such a manner that the particles are porous in nature, which can increase dissolution of the particles.", "Methods for making porous particles are well known in the art.", "(a) Controlled Release Formulations The parenteral formulations described herein comprising one or more compounds as defined in section III.A above for use in accordance with any of the first, second or third aspect of the present invention may be formulated for controlled release including immediate release, delayed release, extended release, pulsatile release, and combinations thereof.", "1.Nano- and Microparticles For parenteral administration, the one or more compounds as defined in section III.A above for use in accordance with any of the first, second or third aspect of the present invention, and optional one or more additional active agents, can be incorporated into microparticles, nanoparticles, or combinations thereof that provide controlled release of the compounds and/or one or more additional active agents.", "In embodiments wherein the formulations contains two or more active components, such as drugs, then they can be formulated for the same type of controlled release (e.g., delayed, extended, immediate, or pulsatile) or they can be independently formulated for different types of release (e.g., immediate and delayed, immediate and extended, delayed and extended, delayed and pulsatile, etc.).", "For example, the compounds and/or one or more additional active agents can be incorporated into polymeric microparticles, which provide controlled release of the active agent(s).", "Release of the active agent (s) is controlled by diffusion of the drug(s) out of the microparticles and/or degradation of the polymeric particles by hydrolysis and/or enzymatic degradation.", "Suitable polymers include ethylcellulose and other natural or synthetic cellulose derivatives.", "Polymers, which are slowly soluble and form a gel in an aqueous environment, such as hydroxypropyl methylcellulose or polyethylene oxide, can also be suitable as materials for drug containing microparticles.", "Other polymers include, but are not limited to, polyanhydrides, poly(ester anhydrides), polyesters, such as polylactide (PLA), polyglycolide (PGA), poly(lactide-co-glycolide) (PLGA), polydioxanone, poly-3-hydroxybutyrate (PHB) and copolymers thereof, poly-4-hydroxybutyrate (P4HB) and copolymers thereof, polycaprolactone and copolymers thereof, polymers including, but not limited to, polymers of glycolic acid, lactic acid, 1,4-dioxanone, trimethylene carbonate, 3-hydroxybutyric acid, 4-hydroxybutyrate, e-caprolactone, including polyglycolic acid, polylactic acid, polydioxanone, polycaprolactone, copolymers of glycolic and lactic acids, such as VICRYL® polymer, MAXON® and MONOCRYL® polymers, and including poly(lactide-co-caprolactones); poly(orthoesters); polyanhydrides; poly(phosphazenes); polyhydroxyalkanoates; synthetically or biologically prepared polyesters; polycarbonates; tyrosine polycarbonates; polyamides (including synthetic and natural polyamides, polypeptides, and poly(amino acids)); polyesteramides; poly(alkylene alkylates); polyethers (such as polyethylene glycol, PEG, and polyethylene oxide, PEO); polyvinyl pyrrolidones or PVP; polyurethanes; polyetheresters; polyacetals; polycyanoacrylates; poly(oxyethylene)/poly(oxypropylene) copolymers; polyacetals, polyketals; polyphosphates; (phosphorous-containing) polymers; polyphosphoesters; polyalkylene oxalates; polyalkylene succinates; poly(maleic acids); silk (including recombinant silks and silk derivatives and analogs); chitin; chitosan; modified chitosan; biocompatible polysaccharides; hydrophilic or water soluble polymers, such as polyethylene glycol, (PEG) or polyvinyl pyrrolidone (PVP), with blocks of other biocompatible or biodegradable polymers, for example, poly(lactide), poly(lactide-co-glycolide, or polycaprolcatone and copolymers thereof, including random copolymers and block copolymers thereof.", "and combinations thereof.", "Alternatively, the active agent can be incorporated into microparticles prepared from materials which are insoluble in aqueous solution or slowly soluble in aqueous solution, but are capable of degrading within the GI tract by means including enzymatic degradation, surfactant action of bile acids, and/or mechanical erosion.", "As used herein, the term “slowly soluble in water” refers to materials that are not dissolved in water within a period of 30 minutes.", "Preferred examples include fats, fatty substances, waxes, wax-like substances and mixtures thereof.", "Suitable fats and fatty substances include fatty alcohols (such as lauryl, myristyl stearyl, cetyl or cetostearyl alcohol), fatty acids and derivatives, including but not limited to fatty acid esters, fatty acid glycerides (mono-, di- and tri-glycerides), and hydrogenated fats.", "Specific examples include, but are not limited to hydrogenated vegetable oil, hydrogenated cottonseed oil, hydrogenated castor oil, hydrogenated oils available under the trade name STEROTEX®, stearic acid, cocoa butter, and stearyl alcohol.", "Suitable waxes and wax-like materials include natural or synthetic waxes, hydrocarbons, and normal waxes.", "Specific examples of waxes include beeswax, glycowax, castor wax, carnauba wax, paraffins and candelilla wax.", "As used herein, a wax-like material is defined as any material, which is normally solid at room temperature and has a melting point of from about 30 to 300° C. In some cases, it may be desirable to alter the rate of water penetration into the microparticles.", "To this end, rate-controlling (wicking) agents can be formulated along with the fats or waxes listed above.", "Examples of rate-controlling materials include certain starch derivatives (e.g., waxy maltodextrin and drum dried corn starch), cellulose derivatives (e.g., hydroxypropylmethyl-cellulose, hydroxypropylcellulose, methylcellulose, and carboxymethyl-cellulose), alginic acid, lactose and talc.", "Additionally, a pharmaceutically acceptable surfactant (for example, lecithin) may be added to facilitate the degradation of such microparticles.", "Proteins, which are water insoluble, such as zein, can also be used as materials for the formation of active agent containing microparticles.", "Additionally, proteins, polysaccharides and combinations thereof, which are water-soluble, can be formulated with drug into microparticles and subsequently cross-linked to form an insoluble network.", "For example, cyclodextrins can be complexed with individual drug molecules and subsequently cross-linked.", "2.Method of Making Nano- and Microparticles Encapsulation or incorporation of active agent, such as the one or more compounds as defined in section III.A above for use in accordance with any of the first, second or third aspect of the present invention, into carrier materials to produce drug-containing microparticles can be achieved through known pharmaceutical formulation techniques.", "In the case of formulation in fats, waxes or wax-like materials, the carrier material is typically heated above its melting temperature and the active agent is added to form a mixture comprising active agent particles suspended in the carrier material, active agent dissolved in the carrier material, or a mixture thereof.", "Microparticles can be subsequently formulated through several methods including, but not limited to, the processes of congealing, extrusion, spray chilling or aqueous dispersion.", "In a preferred process, wax is heated above its melting temperature, active agent is added, and the molten wax-drug mixture is congealed under constant stirring as the mixture cools.", "Alternatively, the molten wax-drug mixture can be extruded and spheronized to form pellets or beads.", "These processes are known in the art.", "For some carrier materials it may be desirable to use a solvent evaporation technique to produce active agent-containing microparticles.", "In this case active agent and carrier material are co-dissolved in a mutual solvent and microparticles can subsequently be produced by several techniques including, but not limited to, forming an emulsion in water or other appropriate media, spray drying or by evaporating off the solvent from the bulk solution and milling the resulting material.", "In some embodiments, active agent in a particulate form is homogeneously dispersed in a water-insoluble or slowly water soluble material.", "To minimize the size of the active agent particles within the composition, the active agent powder itself may be milled to generate fine particles prior to formulation.", "The process of jet milling, known in the pharmaceutical art, can be used for this purpose.", "In some embodiments active agent in a particulate form is homogeneously dispersed in a wax or wax like substance by heating the wax or wax like substance above its melting point and adding the active agent particles while stirring the mixture.", "In this case a pharmaceutically acceptable surfactant may be added to the mixture to facilitate the dispersion of the active agent particles.", "The particles can also be coated with one or more modified release coatings.", "Solid esters of fatty acids, which are hydrolyzed by lipases, can be spray coated onto microparticles or active agent particles.", "Zein is an example of a naturally water-insoluble protein.", "It can be coated onto active agent containing microparticles or active agent particles by spray coating or by wet granulation techniques.", "In addition to naturally water-insoluble materials, some substrates of digestive enzymes can be treated with cross-linking procedures, resulting in the formation of non-soluble networks.", "Many methods of cross-linking proteins, initiated by both chemical and physical means, have been reported.", "One of the most common methods to obtain cross-linking is the use of chemical cross-linking agents.", "Examples of chemical cross-linking agents include aldehydes (gluteraldehyde and formaldehyde), epoxy compounds, carbodiimides, and genipin.", "In addition to these cross-linking agents, oxidized and native sugars have been used to cross-link gelatin.", "Cross-linking can also be accomplished using enzymatic means; for example, transglutaminase has been approved as a GRAS substance for cross-linking seafood products.", "Finally, cross-linking can be initiated by physical means such as thermal treatment, UV irradiation and gamma irradiation.", "To produce a coating layer of cross-linked protein surrounding active agent containing microparticles or active agent particles, a water-soluble protein can be spray coated onto the microparticles and subsequently cross-linked by the one of the methods described above.", "Alternatively, active agent-containing microparticles can be microencapsulated within protein by coacervation-phase separation (for example, by the addition of salts) and subsequently cross-linked.", "Some suitable proteins for this purpose include gelatin, albumin, casein, and gluten.", "Polysaccharides can also be cross-linked to form a water-insoluble network.", "For many polysaccharides, this can be accomplished by reaction with calcium salts or multivalent cations, which cross-link the main polymer chains.", "Pectin, alginate, dextran, amylose and guar gum are subject to cross-linking in the presence of multivalent cations.", "Complexes between oppositely charged polysaccharides can also be formed; pectin and chitosan, for example, can be complexed via electrostatic interactions.", "(b) Injectable/Implantable Formulations The one or more compounds as defined in section III.A above for use in accordance with any of the first, second or third aspect of the present invention can be incorporated into injectable/implantable solid or semi-solid implants, such as polymeric implants.", "In one embodiment, the compounds are incorporated into a polymer that is a liquid or paste at room temperature, but upon contact with aqueous medium, such as physiological fluids, exhibits an increase in viscosity to form a semi-solid or solid material.", "Exemplary polymers include, but are not limited to, hydroxyalkanoic acid polyesters derived from the copolymerization of at least one unsaturated hydroxy fatty acid copolymerized with hydroxyalkanoic acids.", "The polymer can be melted, mixed with the active substance and cast or injection molded into a device.", "Such melt fabrication require polymers having a melting point that is below the temperature at which the substance to be delivered and polymer degrade or become reactive.", "The device can also be prepared by solvent casting where the polymer is dissolved in a solvent and the drug dissolved or dispersed in the polymer solution and the solvent is then evaporated.", "Solvent processes require that the polymer be soluble in organic solvents.", "Another method is compression molding of a mixed powder of the polymer and the drug or polymer particles loaded with the active agent.", "Alternatively, the compounds can be incorporated into a polymer matrix and molded, compressed, or extruded into a device that is a solid at room temperature.", "For example, the compounds can be incorporated into a biodegradable polymer, such as polyanhydrides, polyhydroalkanoic acids (PHAs), PLA, PGA, PLGA, polycaprolactone, polyesters, polyamides, polyorthoesters, polyphosphazenes, proteins and polysaccharides such as collagen, hyaluronic acid, albumin and gelatin, and combinations thereof and compressed into solid device, such as disks, or extruded into a device, such as rods.", "Further alternative polymers for use in this context include polymers include, but are not limited to, polymers of glycolic acid, lactic acid, 1,4-dioxanone, trimethylene carbonate, 3-hydroxybutyric acid, 4-hydroxybutyrate, e-caprolactone, including polyglycolic acid, polylactic acid, polydioxanone, polycaprolactone, copolymers of glycolic and lactic acids, such as VICRYL® polymer, MAXON® and MONOCRYL® polymers, and including poly(lactide-co-caprolactones); poly(orthoesters); polyanhydrides; poly(phosphazenes); polyhydroxyalkanoates; synthetically or biologically prepared polyesters; polycarbonates; tyrosine polycarbonates; polyamides (including synthetic and natural polyamides, polypeptides, and poly(amino acids)); polyesteramides; poly(alkylene alkylates); polyethers (such as polyethylene glycol, PEG, and polyethylene oxide, PEO); polyvinyl pyrrolidones or PVP; polyurethanes; polyetheresters; polyacetals; polycyanoacrylates; poly(oxyethylene)/poly(oxypropylene) copolymers; polyacetals, polyketals; polyphosphates; (phosphorous-containing) polymers; polyphosphoesters; polyalkylene oxalates; polyalkylene succinates; poly(maleic acids); silk (including recombinant silks and silk derivatives and analogs); chitin; chitosan; modified chitosan; biocompatible polysaccharides; hydrophilic or water soluble polymers, such as polyethylene glycol, (PEG) or polyvinyl pyrrolidone (PVP), with blocks of other biocompatible or biodegradable polymers, for example, poly(lactide), poly(lactide-co-glycolide, or polycaprolcatone and copolymers thereof, including random copolymers and block copolymers thereof.", "The release of the one or more compounds from the implant can be varied by selection of the polymer, the molecular weight of the polymer, and/or modification of the polymer to increase degradation, such as the formation of pores and/or incorporation of hydrolyzable linkages.", "Methods for modifying the properties of biodegradable polymers to vary the release profile of the compounds from the implant are well known in the art.", "2.Enteral Formulations The compounds as defined in section III.A above for use in accordance with any of the first, second or third aspect of the present invention and may be formulated for enteral administration.", "Suitable oral dosage forms include tablets, capsules, solutions, suspensions, syrups, and lozenges.", "Tablets can be made using compression or molding techniques well known in the art.", "Gelatin or non-gelatin capsules can be prepared as hard or soft capsule shells, which can encapsulate liquid, solid, and semi-solid fill materials, using techniques well known in the art.", "Formulations may be prepared using a pharmaceutically acceptable carrier.", "As generally used herein “carrier” includes, but is not limited to, diluents, preservatives, binders, lubricants, disintegrators, swelling agents, fillers, stabilizers, and combinations thereof.", "Carrier also includes all components of the coating composition, which may include plasticizers, pigments, colorants, stabilizing agents, and glidants.", "Examples of suitable coating materials include, but are not limited to, cellulose polymers such as cellulose acetate phthalate, hydroxypropyl cellulose, hydroxypropyl methylcellulose, hydroxypropyl methylcellulose phthalate and hydroxypropyl methylcellulose acetate succinate; polyvinyl acetate phthalate, acrylic acid polymers and copolymers, and methacrylic resins that are commercially available under the trade name EUDRAGIT® (Roth Pharma, Westerstadt, Germany), zein, shellac, and polysaccharides.", "Additionally, the coating material may contain conventional carriers such as plasticizers, pigments, colorants, glidants, stabilization agents, pore formers and surfactants.", "“Diluents”, also referred to as “fillers,” are typically necessary to increase the bulk of a solid dosage form so that a practical size is provided for compression of tablets or formation of beads and granules.", "Suitable diluents include, but are not limited to, dicalcium phosphate dihydrate, calcium sulfate, lactose, sucrose, mannitol, sorbitol, cellulose, microcrystalline cellulose, kaolin, sodium chloride, dry starch, hydrolyzed starches, pregelatinized starch, silicone dioxide, titanium oxide, magnesium aluminum silicate and powdered sugar.", "“Binders” are used to impart cohesive qualities to a solid dosage formulation, and thus ensure that a tablet or bead or granule remains intact after the formation of the dosage forms.", "Suitable binder materials include, but are not limited to, starch, pregelatinized starch, gelatin, sugars (including sucrose, glucose, dextrose, lactose and sorbitol), polyethylene glycol, waxes, natural and synthetic gums such as acacia, tragacanth, sodium alginate, cellulose, including hydroxypropylmethylcellulose, hydroxypropylcellulose, ethylcellulose, and veegum, and synthetic polymers such as acrylic acid and methacrylic acid copolymers, methacrylic acid copolymers, methyl methacrylate copolymers, aminoalkyl methacrylate copolymers, polyacrylic acid/polymethacrylic acid and polyvinylpyrrolidone.", "“Lubricants” are used to facilitate tablet manufacture.", "Examples of suitable lubricants include, but are not limited to, magnesium stearate, calcium stearate, stearic acid, glycerol behenate, polyethylene glycol, talc, and mineral oil.", "“Disintegrants” are used to facilitate dosage form disintegration or “breakup” after administration, and generally include, but are not limited to, starch, sodium starch glycolate, sodium carboxymethyl starch, sodium carboxymethylcellulose, hydroxypropyl cellulose, pregelatinized starch, clays, cellulose, alginine, gums or cross linked polymers, such as cross-linked PVP (POLYPLASDONE® XL from GAF Chemical Corp).", "“Stabilizers” are used to inhibit or retard drug decomposition reactions, which include, by way of example, oxidative reactions.", "Suitable stabilizers include, but are not limited to, antioxidants, butylated hydroxytoluene (BHT); ascorbic acid, its salts and esters; Vitamin E, tocopherol and its salts; sulfites such as sodium metabisulphite; cysteine and its derivatives; citric acid; propyl gallate, and butylated hydroxyanisole (BHA).", "(a) Controlled Release Enteral Formulations Oral dosage forms, such as capsules, tablets, solutions, and suspensions, can be formulated for controlled release, for example, for the controlled release of the one or more compounds as defined in section III.A above for use in accordance with any of the first, second or third aspect of the present invention.", "For example, the one or more compounds and optional one or more additional active agents can be formulated into nanoparticles, microparticles, and combinations thereof, and encapsulated in a soft or hard gelatin or non-gelatin capsule or dispersed in a dispersing medium to form an oral suspension or syrup.", "The particles can be formed of the active agent and a controlled release polymer or matrix.", "Alternatively, the active agent particles can be coated with one or more controlled release coatings prior to incorporation in to the finished dosage form.", "In another embodiment, the one or more compounds and optional one or more additional active agents are dispersed in a matrix material, which gels or emulsifies upon contact with an aqueous medium, such as physiological fluids.", "In the case of gels, the matrix swells entrapping the active agents, which are released slowly over time by diffusion and/or degradation of the matrix material.", "Such matrices can be formulated as tablets or as fill materials for hard and soft capsules.", "In still another embodiment, the one or more compounds, and optional one or more additional active agents are formulated into a sold oral dosage form, such as a tablet or capsule, and the solid dosage form is coated with one or more controlled release coatings, such as a delayed release coatings or extended release coatings.", "The coating or coatings may also contain the compounds and/or additional active agents.", "(1) Extended release dosage forms The extended release formulations are generally prepared as diffusion or osmotic systems, which are known in the art.", "A diffusion system typically consists of two types of devices, a reservoir and a matrix, and is well known and described in the art.", "The matrix devices are generally prepared by compressing the drug with a slowly dissolving polymer carrier into a tablet form.", "The three major types of materials used in the preparation of matrix devices are insoluble plastics, hydrophilic polymers, and fatty compounds.", "Plastic matrices include, but are not limited to, methyl acrylate-methyl methacrylate, polyvinyl chloride, and polyethylene.", "Hydrophilic polymers include, but are not limited to, cellulosic polymers such as methyl and ethyl cellulose, hydroxyalkylcelluloses such as hydroxypropyl-cellulose, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, and CARBOPOL® 934 (cross-linked polyacrylate polymer), polyethylene oxides and mixtures thereof.", "Fatty compounds include, but are not limited to, various waxes such as carnauba wax and glyceryl tristearate and wax-type substances including hydrogenated castor oil or hydrogenated vegetable oil, or mixtures thereof.", "In certain preferred embodiments, the plastic material is a pharmaceutically acceptable acrylic polymer, including but not limited to, acrylic acid and methacrylic acid copolymers, methyl methacrylate, methyl methacrylate copolymers, ethoxyethyl methacrylates, cyanoethyl methacrylate, aminoalkyl methacrylate copolymer, poly(acrylic acid), poly(methacrylic acid), methacrylic acid alkylamine copolymer poly(methyl methacrylate), poly(methacrylic acid)(anhydride), polymethacrylate, polyacrylamide, poly(methacrylic acid anhydride), and glycidyl methacrylate copolymers.", "In certain preferred embodiments, the acrylic polymer is comprised of one or more ammonio methacrylate copolymers Ammonio methacrylate copolymers are well known in the art, and are described in NF XVII as fully polymerized copolymers of acrylic and methacrylic acid esters with a low content of quaternary ammonium groups.", "In one preferred embodiment, the acrylic polymer is an acrylic resin lacquer such as that which is commercially available from Rohm Pharma under the tradename EUDRAGIT®.", "In further preferred embodiments, the acrylic polymer comprises a mixture of two acrylic resin lacquers commercially available from Rohm Pharma under the trade names EUDRAGIT® RL30D and EUDRAGIT® RS30D, respectively.", "EUDRAGIT® RL30D and EUDRAGIT® RS30D are copolymers of acrylic and methacrylic esters with a low content of quaternary ammonium groups, the molar ratio of ammonium groups to the remaining neutral (meth)acrylic esters being 1:20 in EUDRAGIT® RL30D and 1:40 in EUDRAGIT® RS30D.", "The mean molecular weight is about 150,000.EUDRAGIT® S-100 and EUDRAGIT® L-100 are also preferred.", "The code designations RL (high permeability) and RS (low permeability) refer to the permeability properties of these agents.", "EUDRAGIT® RL/RS mixtures are insoluble in water and in digestive fluids.", "However, multiparticulate systems formed to include the same are swellable and permeable in aqueous solutions and digestive fluids.", "The polymers described above such as EUDRAGIT® RL/RS may be mixed together in any desired ratio in order to ultimately obtain a sustained-release formulation having a desirable dissolution profile.", "Desirable sustained-release multiparticulate systems may be obtained, for instance, from 100% EUDRAGIT® RL, 50% EUDRAGIT® RL and 50% EUDRAGIT t® RS, and 10% EUDRAGIT® RL and 90% EUDRAGIT® RS.", "One skilled in the art will recognize that other acrylic polymers may also be used, such as, for example, EUDRAGIT® L. Alternatively, extended release formulations can be prepared using osmotic systems or by applying a semi-permeable coating to the dosage form.", "In the latter case, the desired drug release profile can be achieved by combining low permeable and high permeable coating materials in suitable proportion.", "The devices with different drug release mechanisms described above can be combined in a final dosage form comprising single or multiple units.", "Examples of multiple units include, but are not limited to, multilayer tablets and capsules containing tablets, beads, or granules.", "An immediate release portion can be added to the extended release system by means of either applying an immediate release layer on top of the extended release core using a coating or compression process or in a multiple unit system such as a capsule containing extended and immediate release beads.", "Extended release tablets containing hydrophilic polymers are prepared by techniques commonly known in the art such as direct compression, wet granulation, or dry granulation.", "Their formulations usually incorporate polymers, diluents, binders, and lubricants as well as the active pharmaceutical ingredient.", "The usual diluents include inert powdered substances such as starches, powdered cellulose, especially crystalline and microcrystalline cellulose, sugars such as fructose, mannitol and sucrose, grain flours and similar edible powders.", "Typical diluents include, for example, various types of starch, lactose, mannitol, kaolin, calcium phosphate or sulfate, inorganic salts such as sodium chloride and powdered sugar.", "Powdered cellulose derivatives are also useful.", "Typical tablet binders include substances such as starch, gelatin and sugars such as lactose, fructose, and glucose.", "Natural and synthetic gums, including acacia, alginates, methylcellulose, and polyvinylpyrrolidone can also be used.", "Polyethylene glycol, hydrophilic polymers, ethylcellulose and waxes can also serve as binders.", "A lubricant is necessary in a tablet formulation to prevent the tablet and punches from sticking in the die.", "The lubricant is chosen from such slippery solids as talc, magnesium and calcium stearate, stearic acid and hydrogenated vegetable oils.", "Extended release tablets containing wax materials are generally prepared using methods known in the art such as a direct blend method, a congealing method, and an aqueous dispersion method.", "In the congealing method, the drug is mixed with a wax material and either spray-congealed or congealed and screened and processed.", "(2) Delayed Release Dosage Forms Delayed release formulations can be created by coating a solid dosage form with a polymer film, which is insoluble in the acidic environment of the stomach, and soluble in the neutral environment of the small intestine.", "The delayed release dosage units can be prepared, for example, by coating an active agent or an active agent-containing composition with a selected coating material.", "The active agent-containing composition may be, e.g., a tablet for incorporation into a capsule, a tablet for use as an inner core in a “coated core” dosage form, or a plurality of active agent-containing beads, particles or granules, for incorporation into either a tablet or capsule.", "Preferred coating materials include bioerodible, gradually hydrolyzable, gradually water-soluble, and/or enzymatically degradable polymers, and may be conventional “enteric” polymers.", "Enteric polymers, as will be appreciated by those skilled in the art, become soluble in the higher pH environment of the lower gastrointestinal tract or slowly erode as the dosage form passes through the gastrointestinal tract, while enzymatically degradable polymers are degraded by bacterial enzymes present in the lower gastrointestinal tract, particularly in the colon.", "Suitable coating materials for effecting delayed release include, but are not limited to, cellulosic polymers such as hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose acetate succinate, hydroxypropylmethyl cellulose phthalate, methylcellulose, ethyl cellulose, cellulose acetate, cellulose acetate phthalate, cellulose acetate trimellitate and carboxymethylcellulose sodium; acrylic acid polymers and copolymers, preferably formed from acrylic acid, methacrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate and/or ethyl methacrylate, and other methacrylic resins that are commercially available under the tradename EUDRAGIT® (Rohm Pharma; Westerstadt, Germany), including EUDRAGIT® L30D-55 and L100-55 (soluble at pH 5.5 and above), EUDRAGIT® L-100 (soluble at pH 6.0 and above), EUDRAGIT® S (soluble at pH 7.0 and above, as a result of a higher degree of esterification), and EUDRAGITS® NE, RL and RS (water-insoluble polymers having different degrees of permeability and expandability); vinyl polymers and copolymers such as polyvinyl pyrrolidone, vinyl acetate, vinylacetate phthalate, vinylacetate crotonic acid copolymer, and ethylene-vinyl acetate copolymer; enzymatically degradable polymers such as azo polymers, pectin, chitosan, amylose and guar gum; zein and shellac.", "Combinations of different coating materials may also be used.", "Multi-layer coatings using different polymers may also be applied.", "The preferred coating weights for particular coating materials may be readily determined by those skilled in the art by evaluating individual release profiles for tablets, beads and granules prepared with different quantities of various coating materials.", "It is the combination of materials, method and form of application that produce the desired release characteristics, which one can determine only from the clinical studies.", "The coating composition may include conventional additives, such as plasticizers, pigments, colorants, stabilizing agents, glidants, etc.", "A plasticizer is normally present to reduce the fragility of the coating, and will generally represent about 3 wt.", "% to 50 wt.", "%”, or 10 wt % to 50 wt.", "%, relative to the dry weight of the polymer.", "Examples of typical plasticizers include polyethylene glycol, propylene glycol, triacetin, dimethyl phthalate, diethyl phthalate, dibutyl phthalate, dibutyl sebacate, triethyl citrate, tributyl citrate, triethyl acetyl citrate, castor oil and acetylated monoglycerides.", "A stabilizing agent is preferably used to stabilize particles in the dispersion.", "Typical stabilizing agents are nonionic emulsifiers such as sorbitan esters, polysorbates and polyvinylpyrrolidone.", "Glidants are recommended to reduce sticking effects during film formation and drying, and will generally represent approximately 25 wt.", "% to 100 wt.", "% of the polymer weight in the coating solution.", "One effective glidant is talc.", "Other glidants such as magnesium stearate and glycerol monostearates may also be used.", "Pigments such as titanium dioxide may also be used.", "Small quantities of an anti-foaming agent, such as a silicone (e.g., simethicone), may also be added to the coating composition.", "3.Topical Formulations The compounds as defined in section III.A above for use in accordance with any of the first, second or third aspect of the present invention and may be formulated for topical administration.", "The formulations may contain the one or more compounds discussed above, alone or in combination, in an effective amount to prevent or inhibit biofilm formation on a surface, or reduce the amount of biofilm on a surface being treated.", "1000 colony forming units (cfu) of Campylobacter are enough to infect a human and cause disease in a human.", "Therefore, in one embodiment, an effective amount of the one or more compounds as defined in section III.A of this application is, or are, enough of the compound(s), alone, or in combination with other compounds, to reduce the number of cfu of Campylobacter or other microorganism of interest on the surface being treated to a number that is unlikely to, or which will not, cause infection in humans.", "Suitable dosage forms for topical administration include creams, ointments, salves, sprays, gels, lotions, irrigants, and emulsions.", "“Buffers” are used to control pH of a composition.", "Preferably, the buffers buffer the composition from a pH of about 4 to a pH of about 7.5, more preferably from a pH of about 4 to a pH of about 7, and most preferably from a pH of about 5 to a pH of about 7.In a preferred embodiment, the buffer is triethanolamine.", "“Emollients” are an externally applied agent that softens or soothes skin and are generally known in the art and listed in compendia, such as the “Handbook of Pharmaceutical Excipients”, 4th Ed., Pharmaceutical Press, 2003.These include, without limitation, almond oil, castor oil, ceratonia extract, cetostearoyl alcohol, cetyl alcohol, cetyl esters wax, cholesterol, cottonseed oil, cyclomethicone, ethylene glycol palmitostearate, glycerin, glycerin monostearate, glyceryl monooleate, isopropyl myristate, isopropyl palmitate, lanolin, lecithin, light mineral oil, medium-chain triglycerides, mineral oil and lanolin alcohols, petrolatum, petrolatum and lanolin alcohols, soybean oil, starch, stearyl alcohol, sunflower oil, xylitol and combinations thereof.", "In one embodiment, the emollients are ethylhexylstearate and ethylhexyl palmitate.", "“Emulsifiers” are surface active substances which promote the suspension of one liquid in another and promote the formation of a stable mixture, or emulsion, of oil and water.", "Common emulsifiers are: metallic soaps, certain animal and vegetable oils, and various polar compounds.", "Suitable emulsifiers include acacia, anionic emulsifying wax, calcium stearate, carbomers, cetostearyl alcohol, cetyl alcohol, cholesterol, diethanolamine, ethylene glycol palmitostearate, glycerin monostearate, glyceryl monooleate, hydroxpropyl cellulose, hypromellose, lanolin, hydrous, lanolin alcohols, lecithin, medium-chain triglycerides, methylcellulose, mineral oil and lanolin alcohols, monobasic sodium phosphate, monoethanolamine, nonionic emulsifying wax, oleic acid, poloxamer, poloxamers, polyoxyethylene alkyl ethers, polyoxyethylene castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene stearates, propylene glycol alginate, self-emulsifying glyceryl monostearate, sodium citrate dehydrate, sodium lauryl sulfate, sorbitan esters, stearic acid, sunflower oil, tragacanth, triethanolamine, xanthan gum and combinations thereof.", "In one embodiment, the emulsifier is glycerol stearate.", "“Penetration enhancers” are known in the art and include, but are not limited to, fatty alcohols, fatty acid esters, fatty acids, fatty alcohol ethers, amino acids, phospholipids, lecithins, cholate salts, enzymes, amines and amides, complexing agents (liposomes, cyclodextrins, modified celluloses, and diimides), macrocyclics, such as macrocylic lactones, ketones, and anhydrides and cyclic ureas, surfactants, N-methyl pyrrolidones and derivatives thereof, DMSO and related compounds, ionic compounds, azone and related compounds, and solvents, such as alcohols, ketones, amides, polyols (e.g., glycols).", "Examples of these classes are known in the art.", "“Preservatives” can be used to prevent the growth of fungi and microorganisms.", "Suitable antifungal and antimicrobial agents include, but are not limited to, benzoic acid, butylparaben, ethyl paraben, methyl paraben, propylparaben, sodium benzoate, sodium propionate, benzalkonium chloride, benzethonium chloride, benzyl alcohol, cetylpyridinium chloride, chlorobutanol, phenol, phenylethyl alcohol, and thimerosal.", "“Surfactants” are surface-active agents that lower surface tension and thereby increase the emulsifying, foaming, dispersing, spreading and wetting properties of a product.", "Suitable non-ionic surfactants include emulsifying wax, glyceryl monooleate, polyoxyethylene alkyl ethers, polyoxyethylene castor oil derivatives, polysorbate, sorbitan esters, benzyl alcohol, benzyl benzoate, cyclodextrins, glycerin monostearate, poloxamer, povidone and combinations thereof.", "In one embodiment, the non-ionic surfactant is stearyl alcohol.", "(a) Emulsions An emulsion is a preparation of one liquid distributed in small globules throughout the body of a second liquid.", "In particular embodiments, the non-miscible components of the emulsion include a lipophilic component and an aqueous component.", "The dispersed liquid is the discontinuous phase, and the dispersion medium is the continuous phase.", "When oil is the dispersed liquid and an aqueous solution is the continuous phase, it is known as an oil-in-water emulsion, whereas when water or aqueous solution is the dispersed phase and oil or oleaginous substance is the continuous phase, it is known as a water-in-oil emulsion.", "Either or both of the oil phase and the aqueous phase may contain one or more surfactants, emulsifiers, emulsion stabilizers, buffers, and other excipients.", "Preferred excipients include surfactants, especially non-ionic surfactants; emulsifying agents, especially emulsifying waxes; and liquid non-volatile non-aqueous materials, particularly glycols such as propylene glycol.", "The oil phase may contain other oily pharmaceutically approved excipients.", "For example, materials such as hydroxylated castor oil or sesame oil may be used in the oil phase as surfactants or emulsifiers.", "The oil phase may consist at least in part of a propellant, such as an HFA propellant.", "Either or both of the oil phase and the aqueous phase may contain one or more surfactants, emulsifiers, emulsion stabilizers, buffers, and other excipients.", "Preferred excipients include surfactants, especially non-ionic surfactants; emulsifying agents, especially emulsifying waxes; and liquid non-volatile non-aqueous materials, particularly glycols such as propylene glycol.", "The oil phase may contain other oily pharmaceutically approved excipients.", "For example, materials such as hydroxylated castor oil or sesame oil may be used in the oil phase as surfactants or emulsifiers.", "A sub-set of emulsions are the self-emulsifying systems.", "These delivery systems are typically capsules (hard shell or soft shell) comprised of the compound dispersed or dissolved in a mixture of surfactant(s) and lipophilic liquids such as oils or other water immiscible liquids.", "When the capsule is exposed to an aqueous environment and the outer gelatin shell dissolves, contact between the aqueous medium and the capsule contents instantly generates very small emulsion droplets.", "These typically are in the size range of micelles or nanoparticles.", "No mixing force is required to generate the emulsion as is typically the case in emulsion formulation processes.", "(b) Lotions A lotion can contain finely powdered substances that are insoluble in the dispersion medium through the use of suspending agents and dispersing agents.", "Alternatively, lotions can have as the dispersed phase liquid substances that are immiscible with the vehicle and are usually dispersed by means of emulsifying agents or other suitable stabilizers.", "In one embodiment, the lotion is in the form of an emulsion having a viscosity of between 100 and 1000 centistokes.", "The fluidity of lotions permits rapid and uniform application over a wide surface area.", "Lotions are typically intended to dry on the skin leaving a thin coat of their medicinal components on the skin's surface.", "(c) Creams Creams may contain emulsifying agents and/or other stabilizing agents.", "In one embodiment, the formulation is in the form of a cream having a viscosity of greater than 1000 centistokes, typically in the range of 20,000-50,000 centistokes.", "Creams are often time preferred over ointments, as they are generally easier to spread and easier to remove.", "The difference between a cream and a lotion is the viscosity, which is dependent on the amount/use of various oils and the percentage of water used to prepare the formulations.", "Creams are typically thicker than lotions, may have various uses and often one uses more varied oils/butters, depending upon the desired effect upon the skin.", "In a cream formulation, the water-base percentage is about 60-75% and the oil-base is about 20-30% of the total, with the other percentages being the emulsifier agent, preservatives and additives for a total of 100%.", "(d) Ointments Examples of suitable ointment bases include hydrocarbon bases (e.g., petrolatum, white petrolatum, yellow ointment, and mineral oil); absorption bases (hydrophilic petrolatum, anhydrous lanolin, lanolin, and cold cream); water-removable bases (e.g., hydrophilic ointment), and water-soluble bases (e.g., polyethylene glycol ointments).", "Pastes typically differ from ointments in that they contain a larger percentage of solids.", "Pastes are typically more absorptive and less greasy than ointments prepared with the same components.", "(e) Gels Gels are semisolid systems containing dispersions of small or large molecules in a liquid vehicle that is rendered semisolid by the action of a thickening agent or polymeric material dissolved or suspended in the liquid vehicle.", "The liquid may include a lipophilic component, an aqueous component or both.", "Some emulsions may be gels or otherwise include a gel component.", "Some gels, however, are not emulsions because they do not contain a homogenized blend of immiscible components.", "Suitable gelling agents include, but are not limited to, modified celluloses, such as hydroxypropyl cellulose and hydroxyethyl cellulose; Carbopol homopolymers and copolymers; and combinations thereof.", "Suitable solvents in the liquid vehicle include, but are not limited to, diglycol monoethyl ether; alkylene glycols, such as propylene glycol; dimethyl isosorbide; alcohols, such as isopropyl alcohol and ethanol.", "The solvents are typically selected for their ability to dissolve the compound.", "Other additives, which improve the skin feel and/or emolliency of the formulation, may also be incorporated.", "Examples of such additives include, but are not limited to, isopropyl myristate, ethyl acetate, C12-C15 alkyl benzoates, mineral oil, squalane, cyclomethicone, capric/caprylic triglycerides, and combinations thereof.", "(f) Foams Foams consist of an emulsion in combination with a gaseous propellant.", "The gaseous propellant consists primarily of hydrofluoroalkanes (HFAs).", "Suitable propellants include HFAs such as 1,1,1,2-tetrafluoroethane (HFA 134a) and 1,1,1,2,3,3,3-heptafluoropropane (HFA 227), but mixtures and admixtures of these and other HFAs that are currently approved or may become approved for medical use are suitable.", "The propellants preferably are not hydrocarbon propellant gases, which can produce flammable or explosive vapors during spraying.", "Furthermore, the compositions preferably contain no volatile alcohols, which can produce flammable or explosive vapors during use.", "4.Disinfecting and Cleaning Formulations The compounds as defined in section III.A above for use in accordance with any of the first, second or third aspect of the present invention may be formulated into cleaning formulations.", "The cleaning formulations include formulations that are highly efficacious for household cleaning applications (e.g., hard surfaces like floors, countertops, tubs, tile, dishes and softer cloth materials like clothing, sponges, paper towels, etc.", "), personal care applications (e.g.", "lotions, shower gels, soaps, shampoos, sprays, wipes, toothpaste, acne treatments, skin cleansers, mouthwash, wound irrigation solutions, towelettes, contact lenses and lens cases) and industrial and hospital applications (e.g., antifouling coatings, and disinfection of instruments, medical devices, gloves, filters, membranes, tubing, drains, pipes including gas pipes, oil pipes, drilling pipes, fracking pipes, sewage pipes, drainage pipes, hoses, animal carcasses, fish tanks, showers, children's toys, boat hulls, and cooling towers).", "These formulations are efficacious for cleaning surfaces which are infected or contaminated with biofilm or for preventing the formation of biofilm on these surfaces.", "The compounds can be formulated into a solution in a suitable solvent for administration in a spray bottle, the compounds can be formulated as an aerosol, as a foam, suitable for spraying onto surfaces, or, they can be imbibed into a cloth or other item suitable for wiping down a surface to be disinfected.", "Methods for making formulations for use as a disinfectant in the forms are known in the art.", "One embodiment provides the compounds or a derivative thereof in a composition containing a pH dye indicator and an alkaline substance.", "The pH indicator dye indicates what surface has been disinfected and ensures that a sufficient time has passed to disinfect the surface.", "See for example, U.S.", "Publication No.", "20140057987, which is incorporated by reference in its entirety.", "Cleaning formulations can include the compounds and an acceptable carrier.", "The carrier can be in a wide variety of forms.", "For example, the carrier may be an aqueous-based solution or cleanser, an alcohol-based solution or gel or an emulsion carrier, including, but not limited to, oil-in-water, water-in-oil, water-in-oil-in-water, and oil-in-water-in-silicone emulsions.", "The carrier solution containing the compound(s) can be applied directly to the surface to be treated or delivered via a suitable substrate.", "The cleaning formulations can be formulated for use on the skin.", "In these embodiments the compounds can be formulate in a dermatologically acceptable carrier.", "The dermatologically acceptable carriers can also be, for example, formulated as alcohol or water based hand cleansers, toilet bars, liquid soaps, shampoos, bath gels, hair conditioners, hair tonics, pastes, or mousses.", "Cleaning formulations can contain one or more surfactants.", "The surfactant is suitably selected from anionic, nonionic, zwitterionic, amphoteric and ampholytic surfactants, as well as mixtures of these surfactants.", "Such surfactants are well known to those skilled in the detergency art.", "Non limiting examples of possible surfactants include isoceteth-20, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, and sodium lauryl sulfate.", "Examples of a broad variety of additional surfactants are described in McCutcheon's Detergents and Emulsifiers.", "North American Edition (1986), published by Allured Publishing Corporation.", "The cleansing formulations can optionally contain, at their art-established levels, other materials which are conventionally used in cleansing formulations.", "Additional carriers suitable for the cleaning formulations may include various substrate-based products.", "In such instances, the present formulations may be impregnated into or onto the substrate products and may be allowed to remain wet or may be subjected to a drying process.", "For instance, suitable carriers include, but are not limited to, dry and wet wipes suitable for personal care and household use (e.g., nonwoven baby wipes, household cleaning wipes, surgical preparation wipes, etc.", "); diapers; infant changing pads; dental floss; personal care and household care sponges or woven cloths (e.g., washcloths, towels, etc.", "); tissue-type products (e.g.", "facial tissue, paper towels, etc.", "); and disposable garments (e.g., gloves, smocks, surgical masks, infant bibs, socks, shoe inserts, etc.).", "Cleaning formulations can be incorporated into various household care products including, but not limited to, hard surface cleaners (e.g., disinfectant sprays, liquids, or powders); dish or laundry detergents (liquid or solid), floor waxes, glass cleaners, etc.", "Exemplary carriers can include aqueous solutions, e.g.", "having from about 0% to about 98.8%, by weight of the composition, of water.", "Additionally, carriers may contain an aqueous alcohol solution.", "The amount of alcohol present in the alcohol solution will vary depending on the type of product in which the composition is incorporated, i.e.", "say a wipe where the preferred amount of alcohol present would be from about 0% to about 25% whereas a hand sanitizer preferably contains from about 60% to about 95%, of alcohol.", "Therefore, suitable dermatologically acceptable alcohol solutions or gels may contain from about 0% to about 95%, by weight of the composition, of an alcohol.", "Alcohols suitable for inclusion in the alcohol solutions of the carrier include, but are not limited to, monohydric alcohols, dihydric alcohols, and combinations thereof.", "More preferred alcohols are selected from the group consisting of monohydric linear or branched C2-C18 alcohols.", "The most preferred alcohols are selected from the group consisting of ethanol, isopropanol, n-propanol, butanol, and combinations thereof.", "The cleaning formulations which contain an alcohol solution may be anhydrous or water containing.", "Thickeners can be added to the water or alcohol based to form a gel.", "Examples of suitable thickeners include, but are not limited to, naturally-occurring polymeric materials such as sodium alginate, xanthan gum, quince seed extract, tragacanth gum, starch and the like, semi-synthetic polymeric materials such as cellulose ethers (e.g.", "hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxy propylmethyl cellulose), polyvinylpyrrolidone, polyvinylalcohol, guar gum, hydroxypropyl guar gum, soluble starch, cationic celluloses, cationic guars and the like and synthetic polymeric materials such as carboxyvinyl polymers, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid polymers, polymethacrylic acid polymers, polyvinyl acetate polymers, polyvinyl chloride polymers, and polyvinylidene chloride polymers.", "Inorganic thickeners may also be used such as aluminum silicates, such as, for example, bentonites, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate.", "The cleaning formulations can contain, in addition to the compounds described above, one or more antimicrobial or antifungal agents.", "Such agents are capable of destroying microbes, preventing the development of microbes or preventing the pathogenic action of microbes.", "Examples of additional antimicrobial and antifungal agents include β-lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, 2,4,4′-trichloro-2′-hydroxy diphenyl ether (TRICLOSAN®), phenoxyethanol, phenoxy propanol, phenoxyisopropanol, doxycycline, capreomycin, chlorhexidine, chlortetracycline, oxytetracycline, clindamycin, ethambutol, hexamidine isethionate, metronidazole, pentamidine, gentamicin, kanamycin, lineomycin, methacycline, methenamine, minocycline, neomycin, netilmicin, paromomycin, streptomycin, tobramycin, miconazole, tetracycline hydrochloride, erythromycin, zinc erythromycin, erythromycin estolate, erythromycin stearate, amikacin sulfate, doxycycline hydrochloride, capreomycin sulfate, chlorhexidine gluconate, chlorhexidine hydrochloride, chlortetracycline hydrochloride, oxytetracycline hydrochloride, clindamycin hydrochloride, ethambutol hydrochloride, metronidazole hydrochloride, pentamidine hydrochloride, gentamicin sulfate, kanamycin sulfate, lineomycin hydrochloride, methacycline hydrochloride, methenamine hippurate, methenamine mandelate, minocycline hydrochloride, neomycin sulfate, netilmicin sulfate, paromomycin sulfate, streptomycin sulfate, tobramycin sulfate, miconazole hydrochloride, ketaconazole, amanfadine hydrochloride, amanfadine sulfate, octopirox, parachlorometa xylenol, nystatin, tolnaftate, pyrithiones (especially zinc pyrithione which is also known as ZPT), dimethyldimethylol hydantoin (GLYDANT®), methylchloroisothiazolinone/methylisothiazolinone (KATHON CG®), sodium sulfite, sodium bisulfite, imidazolidinyl urea (Germall 115®), diazolidinyl urea (GERMAILL benzyl alcohol, 2-bromo-2-nitropropane-1,3-diol (BRONOPOL®), formalin (formaldehyde), iodopropenyl butylcarbamate (POLYPHASE P100®), chloroacetamide, methanamine, methyldibromonitrile glutaronitrile (1,2-Dibromo-2,4-dicyanobutane or TEKTAMER®), glutaraldehyde, 5-bromo-5-nitro-1,3-dioxane (BRONIDOX®), phenethyl alcohol, o-phenylphenol/sodium o-phenylphenol, sodium hydroxymethylglycinate (SUTTOCIDE A®), polymethoxy bicyclic oxazolidine (NUOSEPt C®), dimethoxane, thimersal dichlorobenzyl alcohol, captan, chloφhenenesin, dichlorophene, chlorbutanol, glyceryl laurate, halogenated diphenyl ethers like 2,4,4′-trichloro-2′-hydroxy-diphenyl ether (TRICLOSAN® or TCS), 2,2′-dihydroxy-5,5′-dibromo-diphenyl ether, phenolic compounds like phenol, 2-methyl phenol, 3-methyl phenol, 4-methyl phenol, 4-ethyl phenol, 2,4-dimethyl phenol, 2,5-dimethyl pPhenol, 3,4-dimethyl phenol, 2,6-dimethyl phenol, 4-n-propyl phenol, 4-n-butyl phenol, 4-n-amyl phenol, 4-tert-amyl phenol, 4-n-hexyl phenol, 4-n-heptyl phenol, mono- and poly-alkyl and aromatic halophenols such as p-chlorophenol, methyl p-chlorophenol, ethyl p-chlorophenol, n-propyl p-chlorophenol, n-butyl p-chlorophenol, n-amyl p-chlorophenol, sec-amyl p-chlorophenol, n-hexyl p-chlorophenol, cyclohexyl p-chlorophenol, n-heptyl p-chlorophenol, n-octyl p-chlorophenol, o-chlorophenol, methyl o-chlorophenol, ethyl o-chlorophenol, n-propyl o-chlorophenol, n-butyl o-chlorophenol, n-amyl o-chlorophenol, tert-amyl o-chlorophenol, n-hexyl o-chlorophenol, n-heptyl o-chlorophenol, o-benzyl p-chlorophenol, o-benzyl-m-methyl p-chlorophenol, o-benzyl-m, m-dimethyl p-chlorophenol, o-phenylethyl p-chlorophenol, o-phenylethyl-m-methyl p-chlorophenol, 3-methyl p-chlorophenol, 3,5-dimethyl p-chlorophenol, 6-ethy 1-3-methyl p-chlorophenol, 6-n-propyl-3-methyl p-chlorophenol, 6-iso-propyl-3-methyl p-chlorophenol, 2-ethyl-3,5-dimethyl p-chlorophenol, 6-sec-butyl-3-methyl p-chlorophenol, 2-iso-propyl-3,5-dimethyl p-chlorophenol, 6-diethylmethyl-3-methyl p-chlorophenol, 6-iso-propyl-2-ethyl-3-methyl p-chlorophenol, 2-sec-amyl-3,5-dimethyl p-chlorophenol, 2-diethylmethyl-3,5-dimethyl p-chlorophenol, 6-sec-octyl-3-methyl p-chlorophenol, p-chloro-m-cresol, p-bromophenol, methyl p-bromophenol, ethyl p-bromophenol, n-propyl p-bromophenol, n-butyl p-bromophenol, n-amyl p-bromophenol, sec-amyl p-bromophenol, n-hexyl p-bromophenol, cyclohexyl p-bromophenol, o-bromophenol, tert-amyl o-bromophenol, n-hexyl o-bromophenol, n-propyl-m,m-dimethyl o-bromophenol, 2-phenyl phenol, 4-chloro-2-methyl phenol, 4-chloro-3-methyl phenol, 4-chloro-3,5-dimethyl phenol, 2,4-dichloro-3,5-dimethylphenol, 3,4,5,6-terabromo-2-methylphenol, 5-methyl-2-pentylphenol, 4-isopropyl-3-methylphenol, para-chloro-meta-xylenol (PCMX), chlorothymol, 5-chloro-2-hydroxydiphenylmethane, resorcinol and its derivatives including methyl resorcinol, ethyl resorcinol, n-propyl resorcinol, n-butyl resorcinol, n-amyl resorcinol, n-hexyl resorcinol, n-heptyl resorcinol, n-octyl resorcinol, n-nonyl resorcinol, phenyl resorcinol, benzyl resorcinol, phenylethyl resorcinol, phenylpropyl resorcinol, p-chlorobenzyl resorcinol, 5-chloro 2,4-dihydroxydiphenyl methane, 4′-chloro 2,4-dihydroxydiphenyl methane, 5-bromo 2,4-dihydroxydiphenyl methane, and 4′-bromo 2,4-dihydroxydiphenyl methane, bisphenolic compounds like 2,2′-methylene bis (4-chlorophenol), 2,2′-methylene bis (3,4,6-trichlorophenol), 2,2′-methylene bis (4-chloro-6-bromophenol), bis (2-hydroxy-3,5-dichlorophenyl) sulphide, and bis (2-hydroxy-5-chlorobenzyl)sulphide, benzoic esters (parabens) like methylparaben, propylparaben, butylparaben, ethylparaben, isopropylparaben, isobutylparaben, benzylparaben, sodium methylparaben, and sodium propylparaben, halogenated carbanilides (e.g., 3,4,4′-trichlorocarbanilides (TRICLOCARBAN® or TCC), 3-trifluoromethyl-4,4′-dichlorocarbanilide, 3,3′,4-trichlorocarbanilide, etc.", "), cationic actives such as benzalkonium chloride, and clotrimazole.", "Another class of antimicrobial agents (specifically antibacterial agents) which are useful, are the so-called “natural” antibacterial actives, referred to as natural essential oils.", "Typical natural essential oil antibacterial actives include oils of anise, lemon, orange, rosemary, wintergreen, thyme, lavender, cloves, hops, tea tree, citronella, wheat, barley, lemongrass, cedar leaf, cedarwood, cinnamon, fleagrass, geranium, sandalwood, violet, cranberry, eucalyptus, vervain, peppermint, gum benzoin, basil, fennel, fir, balsam, menthol, ocmea origanum, Hydastis carradensis, Berberidaceae daceae, Ratanhiae and Curcuma longa.", "The cleaning formulations may be packaged in a variety of suitable packaging known to those skilled in the art.", "The liquid formulations may desirably be packaged in manually operated spray dispensing containers, which are usually made of synthetic organic polymeric plastic materials.", "Accordingly, disinfecting formulations containing the compounds and packaged in a spray dispenser, preferably in a trigger spray dispenser or a pump spray dispenser, are envisioned.", "Spray-type dispensers allow to uniformly apply to a relatively large area of a surface to be disinfected a liquid cleaning formulations described herein.", "The compounds can be impregnated into a nonwoven absorbent wipe.", "Disinfectant wet wipes are also disclosed for example in U.S. Pat.", "No.", "8,563,017.The compounds can be in an aqueous foam with a special surfactant system capable of generating a foam.", "See U.S. Pat.", "No.", "8,097,265, U.S. Pat.", "No.", "5,891,922 and U.S. Pat.", "No.", "4,889,645.The compounds can also be in a pressurized spray aerosol.", "See also, U.S.", "Publication No.", "20010053333 which discloses a liquid flash-dry aerosol disinfectant composition with a flash vaporization component and an effective amount of an antimicrobial agent.", "It is within the abilities of one of ordinary skill in the art to determine the effective amount of the compounds to include in an aerosol, foam, solution or disinfectant cloth for the purpose of sterilizing for example, high risk hospital surfaces.", "D. Conjugation and Immobilization of Compounds The one or more compounds as defined in section III.A above for use in accordance with any of the first, second or third aspect of the present invention and may be presented as conjugated and/or immobilized compounds.", "The compounds may be conjugated with other agents in order to retain the compounds on surfaces, for example, to prevent biofilm formation on a surface.", "In one embodiment, the compounds may be conjugated to an agent that has affinity for a surface in order to retain the compounds on that surface.", "For example, the compounds may be conjugated to an agent wherein the agent is a polymer or oligomer, and the polymer or oligomer has a high affinity for the surface.", "In another embodiment the compounds may be conjugated to an agent wherein the agent comprises a reactive moiety suitable for anchoring to a surface.", "The reactive moiety may, for example, be photo-reactive, or capable of coupling covalently to a surface.", "The reactive moiety may also incorporate spacers and linkers and other functional groups in order to place the compound in a desired location relative to the surface.", "FIGS.", "15A-C are examples of how FeQ (Fe-QA) may be conjugated to an agent comprising a reactive moiety suitable for anchoring to a surface.", "In each of the three examples, FeQ is conjugated to a calix[4] arene frame that comprises a reactive moiety.", "In FIG.", "15A, FeQ is conjugated via a linker to a calix[4] arene frame that contains a photoreactive functional group.", "FIG.", "15B is a variant of FIG.", "15A which shows that the reactive moiety can be positioned at a different location on the calix[4] arene frame.", "FIG.", "15C is an example of FeQ conjugated to a calix[4] arene frame, wherein the latter is functionalized with thiol groups that are capable of reacting with surfaces.", "It should be understood that different linkers or no linkers may be used, and that other agents may be used instead of the calix[4] arene frame, including cyclodextrins and other polymers and oligomers.", "In yet another embodiment, the compounds may be conjugated to an agent that comprises a substance with an affinity for a surface.", "The agent may incorporate spacers and linkers and other functional groups in order to place the compound in the desired location relative to the surface.", "In one embodiment, the agent contains hydroxyapatite.", "FIGS.", "16 A and B are examples of how FeQ (Fe-QA) may be conjugated via a linker to hydroxyapatite.", "In these examples, the linkers are attached in different positions to one of the quinic acid ligands via a functional group, Y′, and at the other end of the linker are attached to hydroxyapatite (HA) via a second functional group, X′.", "In an alternative embodiment, the HA group in the structures of FIGS.", "16A and B may be replaced with a reactive group that can attach (or be attached) to a surface, such as a photo-reactive compound, isocyanate, hydroxy group, amine, trialkoxysilyl ether, such as a triethoxysilyl ether, or phosphate ester.", "These groups may be attached directly to the polyethylene glycol, or an additional linker inserted between the reactive group and the polyethylene glycol.", "E. Feeds and Feed Supplements In accordance with the first aspect of the present invention, a further embodiment of the present invention provides that the compounds as defined in section III.A can be formulated into growth promoting formulations.", "The one or more compounds may be used, for example, in feed or formula to improve the growth of chicken, for example, a meat-type chicken such as broiler chicken, or an egg-laying chicken such as a pullet or hen, or a breeder chicken, other poultry, such as a turkey, geese, quail, pheasant, or ducks, or livestock such as cattle, sheep, goats, swine, alpaca, banteng, bison, camel, cat, deer, dog, donkey, gayal, guinea pig, horse, llama, mule, rabbit, reindeer, water buffalo, yak, although the skilled person will appreciate that other feeds for animals, including zoo animals, captive animals, game animals, fish (include freshwater and saltwater fish, farmed fish, and ornamental fish), other marine and aquatic animals, including shellfish such as, but not limited to, oysters, mussels, clams, shrimps, prawns, lobsters, crayfish, crabs, cuttlefish, octopus, and squid, domestic animals such as cats and dogs, rodents (such as mice, rats, guinea pigs, hamsters), and horses, are also provided, as well as any other domestic, wild and farmed animal, including mammals, marine animals, amphibians, birds, reptiles, insects and other invertebrates.", "The one or more compounds may be added to drinking water for any of said animals to improve growth The compounds may be useful in treatment of ponds, tanks, or other aquatic or marine environments containing fish (include freshwater and saltwater fish, farmed fish and ornamental fish), other marine and aquatic animals, including shellfish or crustaceans such as shrimp, oysters, mussels, clams, prawns, lobsters, crayfish, crabs, cuttlefish, octopus and crawfish.", "The one or more compounds may be used alone or in combination with other anti-microbial, bactericidal or bacteriostatic compounds (for example, in accordance with the second or third aspect of the present invention) and/or growth enhancing agents.", "The compounds as defined in section III.A can improve growth performance, and can be used to increase average body weight during growth.", "The compounds can also be used to improve feed conversion ratio.", "In particular, the compounds can be used to decrease the mortality adjusted feed conversion ratios (MFCR).", "The compounds may be used to produce animals with higher average body weight in a given period of time, or may be used to reach a target average body weight in a shorter period of time.", "The compounds may be used to decrease the amount of feed necessary for an animal to attain a target weight.", "In addition, the compounds may be used in stressed environments to improve growth and MFCR.", "These environments include but are not limited to high stocking densities of animals, dirty pen litter, presence of pathogens, presence of Campylobacter and other bacteria, and high temperature environments.", "The compositions are particularly useful in feeds for commercial birds such as chickens, turkeys, pheasants, and ducks.", "Exemplary poultry feeds in which the as one or more compounds defined in section III.A can be included, include poultry feeds that are referred to as “complete” feeds, because they are designed to contain all the protein, energy, vitamins, minerals, and other nutrients necessary for proper growth, egg production, and health of the birds.", "Feeding any other ingredients, mixed with the feed or fed separately, upsets the balance of nutrients in the “complete” feed.", "Feeding additional grain or supplement with the complete poultry feed is not recommended.", "Chickens used in optimized commercial broiler production are typically fed different diets depending upon their age.", "For example, chickens for broiler production may be raised using three diets.", "These diets are typically called a “starter”, “grower” and “finisher”.", "The starter diet may be fed for about the first 10-12 days (typically in the range of 7-14 days).", "This starter diet is followed by the grower diet, which is provided to the broilers for almost 2 weeks (typically from about 11-24 days).", "The finisher diet is used for the remainder of the production period (typically from 24 to 42 days).", "Some broiler houses will use more or less diets (for example 4 diets), and vary the timing of diet changes.", "Broilers are typically harvested between 30 and 42 days, although this time can be longer or shorter.", "Further details and options are discussed above in the context of the first aspect of the present invention.", "F. Treatment to Promote Growth As discussed above in more detail, in the context of the first aspect of the present invention, it has been discovered that the one or more compounds defined in section III.A of this application, above, are particularly useful in promoting growth.", "The compounds may be added to animal feed or animal drinking water in order to promote growth.", "Addition of the compounds to feed or drinking water results in improved growth.", "It has also been discovered that the compounds can be added to animal feed or animal drinking water in order to decrease the mortality adjusted feed conversion ratio.", "Thus it is possible to use the compounds to decrease the amount of feed necessary for an animal to grow.", "The compounds may further be administered with other animal additives, and may be administered in commercial feeds.", "In a preferred embodiment, the compounds are administered in feeds.", "It has also been discovered that the compounds can be administered to animals that are in a stressed environment in order to improve their growth performance.", "In a stressed environment the compounds promote growth that yields animals with higher average body weights.", "The compounds also decrease mortality adjusted feed conversion ratios in stressed environments.", "EXAMPLES The following non-limiting examples are included to demonstrate particular embodiments of the various aspects of the present invention.", "It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventor to function well in the practice of the invention, and thus can be considered to constitute preferred modes for its practice.", "However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.", "Example 1.Inhibition of Biofilm Formation on Beads Surface by Enterococcus faecalis NCTC 12697 Using Fe-QA Materials and Methods Bacteria (Enterococcus faecalis NCTC 12697, Staphylococcus epidermidis F1513 and Staphylococcus aureus ATCC 25923) were grown on Brain heart infusion (BHI) passaged to new medium either containing Fe-QA or alone.", "Growth suspensions were prepared at 0.0001 OD/ml and then allowed to grow at 37° C. under normal atmospheric conditions for 24 h in BHI with plastic coated UV beads (Lascells).", "After 48 h, 10 μl suspension was serially diluted 10 fold to 10-3, 10-4, 10-5, 10-6, 10-7, 10-8.For each dilution, 10 μl was spotted on BHI agar plates and colonies counted after 24 h. The beads were also removed washed in PBS before adding to 1 ml PBS.", "After vortex mixing, 10 μl of the cell suspension was serially diluted as above and cell counts carried out.", "Results Enterococcus faecalis causes many of the antibiotic resistant infections in hospitals, a consequence of its inherent resistance to certain antibiotics and of its ability to survive and proliferate in the intestinal tract.", "A Ser/Thr kinase in Enterococcus faecalis is found to mediate antimicrobial resistance.", "Studies have shown that PrkC, a one-component signaling protein containing a eukaryotic-type Ser/Thr kinase domain, allowed for inherent antimicrobial resistance and intestinal persistence of E. faecalis (Kristich, et al., Proc.", "Nat.", "Acad.", "Sci.", "USA, 104(9):3508-3513 (2007)).", "Kristich, et al.", "found that an E. faecalis mutant lacking PrkC grew at a wild-type rate in the absence of antimicrobial stress but showed enhanced sensitivity to cell-envelope-active compounds, including antibiotics that targeted cell-wall biogenesis and bile detergents.", "PrkC regulates physiological processes in E. faecalis that are key to its success as a nosocomial pathogen.", "The effect of Fe-QA on biofilm formation by E. faecalis was tested as described in the materials and methods.", "The data (FIGS.", "1A and 1B) shows that Fe-QA inhibited E. faecalis biofilm formation as measured following treatment of E. faecalis grown on plastic coated UV beads.", "Example 2.Inhibition of Biofilm Formation on Beads Surface by Staphylococcus epidermidis F1513 Using Fe-QA Materials and Methods The effect of Fe-QA on biofilm formation by S. epidermidis F1513 was tested as described in the materials and methods of Example 1.Results The data (FIGS.", "2A and 2B) shows that Fe-QA inhibited S. epidermidis biofilm formation as measured following treatment of S. epidermidis grown on plastic coated UV beads.", "Example 3.Inhibition of Biofilm Formation on Beads Surface by Staphylococcus aureus ATCC 25923 Using Fe-QA The treatment of choice for S. aureus infection is penicillin; in most countries, however, penicillin resistance is extremely common, and first-line therapy is most commonly a penicillinase-resistant β-lactam antibiotic (for example, oxacillin or flucloxacillin).", "Combination therapy with gentamicin may be used to treat serious infections, such as endocarditis, but its use is controversial because of the high risk of damage to the kidneys (Cosgrove, et al., Clin Infect Dis, 48(6):713-721 (2009).", "The duration of treatment depends on the site of infection and on severity.", "Materials and Methods The effect of Fe-QA on biofilm formation by S. aureus was tested as described in the materials and methods of Example 1.Results The data (FIGS.", "3A and 3B) shows that Fe-QA inhibited S. aureus biofilm formation as measured following treatment of S. aureus grown on plastic coated UV beads.", "Example 4.Phenotypic Changes and Inhibition of Campylobacter jejuni NCTC 11168 Binding to Histo-Blood Group Antigens by Fe-QA Materials and Methods Binding of C. jejuni NCTC 11168 to the BgAgs (common ABO histo-blood group antigens), Leb and H-II was measured after growing the bacteria in a medium that has either Fe-QA at 0.34 mM or 3.4 mM.", "The binding is measured by washing away the Fe-Q containing medium prior to testing the bacteria by ELISA as described below.", "Binding was measured after one passage and four passages (4 generations) with Fe-QA included in the medium, and compared to a control without Fe-QA.", "Binding of C. jejuni 11168 to BgAgs (common ABO histo-blood group antigens) that are expressed, for example, on the surfaces of erythrocytes, and the inhibition of this binding by Fe-QA was quantified using the ELISA method described below.", "The ELISA was performed as follows: BSA-BgAg conjugates were obtained from IsoSep, Tullinge, Sweden.", "Coupling of BgAgs to 96-well plates (NUNC Immobilizer Amino) was carried Out by the addition of 100 μl BSA-BgAg (5 μg/ml unless stated otherwise) in sodium carbonate buffer to each well.", "Plates were incubated at room temperature for 2 ft before unbound reagent was removed by washing three times in PBS-T. All wells were blocked by the addition of 100 nil 1% BSA/PBS and incubated for 2 h at room temperature.", "After further washing in PBS-T, 100 ml of DIG-tagged bacteria (at OD600 of 0.05) were added to each well and incubated overnight at 4° C. Plates were washed three times in PBS-T before 100 ml anti-digoxigenin-POD solution (Roche Diagnostics; 1 in 5000 diluted in 1% BSA/PBS) was added and incubated for 1 h at room temperature.", "Plates were again vigorously washed in PBS-T and color developed by adding 100 μl ABTS substrate (Roche).", "Plates were read with an ELISA reader (Biotek EL800) at an absorbance of 405 nm.", "Specific binding was determined by subtracting the binding of each strain to BSA (typically OD405 0.07-0.09) from the binding to each BSA-BgAg conjugate.", "Inhibition assays shown in FIG.", "4B were carried out as above but after the removal of the blocking solution, DIG-labeled C. jejuni was pre-incubated for 4 h with an Fe-QA solution (0.34 mM) before being added to each well.", "Results FIG.", "4A shows the binding of C. jejuni to the BgAgs (common ABO histo-blood group antigens), Leb and H-II, after growing the bacteria in a medium that has either Fe-QA at 0.34 mM or 3.4 mM.", "The results show a marked decrease in binding to Leb and H-II particularly in the group that was treated with the higher concentration of Fe-QA (3.4 mM).", "A statistically significant decrease was also found at the lower Fe-QA concentration of 0.34 mM when compared to the control group.", "It is therefore apparent that treating the bacteria with Fe-QA for several generations results in a phenotypic change, and the bacteria lose the ability to bind to the BgAg's permanently.", "FIG.", "4B shows the binding of C. jejuni 11168 to BgAgs (common ABO histo-blood group antigens) that are expressed, for example, on the surfaces of erythrocytes, and the inhibition of this binding by Fe-QA.", "Binding is quantified using the ELISA method described below.", "The bar graphs show binding for the non-treated C. jejuni 11168-NT (NT=non-treated) to BgAgs, and the significant inhibition of binding by pre-incubation of the bacteria with Fe-QA prior to adding the bacteria to the ELISA plate.", "Example 5.Inhibition of Helicobacter pylori CCUG 17875 Attachment to Human Gastric Tissue Materials and Methods The ability of H. pylori CCUG 17875 to bind to samples of human gastric tissue in the presence of Lewis b antigen, Leb, and two concentrations of Fe-QA (1 mM and 0.2 mM) was measured.", "Binding was quantified by fluorescence using H. pylori that had been labeled with fluorescein using FITC (fluorescein isothiocyanate), and human gastric tissue that was embedded in parafilm.", "The bacteria were suspended in blocking buffer (1% BSA in PBS) and applied to re-hydrated histo-sections of human gastric tissue.", "Binding was assessed microscopically, and quantified as the average number of bacteria bound to the tissue.", "Binding of Leb to H. pylori strain 17875 at pH 7.4 was assayed by labeling Leb with radioactive iodine (I-125), mixing the radioactive antigen with H. pylori bacteria, pelletizing the bacteria using a centrifuge, and measuring the radioactivity in the pellet and in the supernatant.", "Any Leb that is bound to the bacteria is quantified by the measurement of radioactivity in the pellet.", "The ratio of the radioactivity in the pellet to the supernatant therefore corresponds to the ratio of Leb bound by the bacteria to that which remains unbound, expressed as bound/free.", "Results The ability of H. pylori to bind to samples of human gastric tissue in the presence of Lewis b antigen, Leb, and two concentrations of Fe-QA (1 mM and 0.2 mM) is shown in FIG.", "5A The results show that the binding of H. pylori to human gastric tissue is significantly reduced in the presence of Leb (10 μg/ml) and Fe-QA at both 1 mM and 0.2 mM concentrations when incubated for 1 hour at room temperature.", "Reduction in bacterial binding was estimated by counting the number of specifically adhered bacteria to the gastric pit region under 200× magnification.", "Fe-QA therefore prevents bacterial attachment of H. pylori to gastric epithelium.", "FIG.", "5B shows the competitive inhibition of Leb binding to H. pylori by Fe-QA as the concentration of Fe-QA is increased.", "The graph is a plot of the ratio of bound/free Leb versus Fe-QA concentration (μM).", "The graph shows that Fe-QA increasingly inhibits binding of the Leb to H. pylori as the amount of Fe-QA is increased.", "Example 6.Fe-QA Prevention of Biofilm Formation by Pseudomonas aeruginosa and Uropathogenic E. coli (UPEC) Materials and Methods Pseudomonas aeruginosa PAO-1, and a clinically isolated uropathogenic Escherichia coli UPEC-536 were routinely grown on either LB (Luria-Bertani, Oxoid, UK) agar plates at 37° C. or in broth at 37° C. with 200 rpm shaking.", "UV-sterilized glass slides were incubated in either 15 mL RPMI-1640 defined medium (Sigma, UK) or 15 mL RPMI-1640 with Fe-QA inoculated with diluted (OD600=0.01) bacteria from overnight cultures at 37° C. with 60 rpm shaking for 72 hours.", "The slides were removed from bacterial culture and washed with 15 mL phosphate buffered saline at room temperature for 5 minutes three times and then rinsed with distilled H2O.", "After washing, the slides were stained with 20 μM SYTO17 dye (Invitrogen, UK) at room temperature for 30 minutes.", "After removing excess staining dye and air-drying, the samples were examined using a Carl Zeiss LSM 700 Laser Scanning Microscope with ZEN 2009 imaging software (Carl Zeiss, Germany).", "The coverage rate of bacteria on the surface was analysed using open source Image J 1.44 software (National Institute of Health, US).", "Results FIG.", "6A shows that Fe-QA (“X”) at 100 μM inhibits the formation of biofilm by Pseudomonas aeruginosa.", "In the absence of Fe-QA, a higher coverage rate was measured for Pseudomonas aeruginosa than in the presence of a 100 μM concentration of Fe-QA.", "FIG.", "6B shows that Fe-QA inhibits the formation of biofilm by Uropathogenic E. coli (UPEC).", "In the absence of Fe-Q (“0 μM), a higher coverage rate is measured for UPEC than in the presence of 0.1 μM, 1 μM, 10 μM and 100 μM concentrations of Fe-QA.", "Example 7.Planktonic Growth of Bacteria in the Presence of Fe-QA Materials and Methods The growth rate of Uropathogenic E. coli UPEC-536 in RPMI-1640 media over a period of 24 hours was compared to the growth rate of UPEC in RPMI-1640 media, but in the presence of 100 μM Fe-QA.", "The growth rate of Pseudomonas aeruginosa in RPMI-1640 media was also compared to the growth rate of Pseudomonas aeruginosa in RPMI-1640 media, but in the presence of 100 μM Fe-QA.", "Results FIG.", "7A is a graph showing the growth rate of UPEC in RPMI-1640 media over a period of 24 hours.", "The growth rate is compared to the growth rate of UPEC in RPMI-1640 media, but in the presence of 100 μM Fe-QA.", "(The optical absorbance of the RPMI-1640 is also shown for reference.)", "The graph demonstrates that Fe-QA does not inhibit the growth of UPEC.", "However, as shown in Example 6 and FIG.", "6B, Fe-QA inhibits biofilm formation.", "Therefore, the inhibition of biofilm formation is not due to bacterial growth inhibition.", "FIG.", "7B is a graph showing the growth rate of Pseudomonas aeruginosa in RPMI-1640 media.", "The growth rate is compared to the growth rate of Pseudomonas aeruginosa in RPMI-1640 media, but in the presence of 100 μM Fe-QA.", "(The optical absorbance of the RPMI-1640 is also shown for reference.)", "The graph demonstrates that Fe-QA does not inhibit the growth of Pseudomonas aeruginosa as was also found for UPEC (above).", "However, as shown in Example 6 and FIG.", "6A, Fe-QA inhibits biofilm formation of Pseudomonas aeruginosa.", "Therefore, the inhibition of biofilm formation is not due to bacterial growth inhibition.", "Example 8.Planktonic Growth Versus Biofilm Growth of C. jejuni MOMP T268G Mutant Materials and Methods A MOMP-T strain of Campylobacter jejuni NCTC 11168 was prepared by mutating T268 of MOMP.", "The T268 of MOMP was replaced with glycine.", "The planktonic growth of the MOMP-T strain of Campylobacter jejuni and its ability to form a biofilm compared to the wild type strain was determined.", "Bacteria (wildtype and the MOMP-T strain) were grown on CCDA selective charcoal agar and then passaged to Mueller-Hinton broth (MHB).", "Growth suspensions were prepared at 0.02 OD/ml and then allowed to grow at 37° C. under atmospheric conditions (5% CO2, 6% O2) for 48 h in MHB with plastic coated UV beads (Lascells).", "After 48 h, 10 μl suspension was serially diluted 10 fold to 10−3, 10−4, 10−5, 10−6, 10−7, and 10−8.For each dilution, 10 μl was spotted on CCDA selective agar plates and colonies counted after 48 h. The beads were also removed and washed in PBS before adding to 1 ml PBS.", "After vortex mixing, 10 μl of the cell suspension was serially diluted as above and cell counts carried out to quantify biofilm formation.", "Results FIG.", "8A shows that mutation of T268 of MOMP does not impact the growth of Campylobacter jejuni relative to wildtype even though it is known that T268 of MOMP is O-glycosylated.", "However, FIG.", "8B shows that mutation of T268 of MOMP does impact biofilm formation.", "The experiment demonstrates that O-glycosylation of MOMP at T268 in Campylobacter is vital for biofilm formation, and the necessity of the MOMP-T268 glycan for aggregation and biofilm formation.", "Example 9.Fe-QA Treatment Makes Antibiotic Resistant Strain of E. coli Lose Resistance to Antibiotics Materials and Methods A kanamycin resistance gene was introduced into the genome of Enteropathogenic E. coli EPEC, (E2348/69), genotype; Wildtype EPEC-O-17:H6 allowing the kanamycin resistant strain of EPEC to grow in the presence of a patch that has been immersed in kanamycin (at a concentration of 50 μg/mL).", "The kanamycin resistant strain of EPEC was then immersed in a patch in a solution of Fe-QA.", "Results Immersing a patch in a solution of Fe-QA, and then placing the patch on a growth plate with the kanamycin resistant strain also had no significant effect on bacterial growth.", "However, immersing the patch in a solution of Fe-QA and kanamycin, and then placing on a growth plate caused the bacteria to fail to grow.", "The experiment demonstrates that Fe-QA has no significant impact on the growth of the bacteria.", "However, Fe-QA makes the bacteria more sensitive to kanamycin even though the bacteria carry a kanamycin resistant gene, and is therefore resistant to the antibiotic.", "The Fe-QA can therefore be used in conjunction with antibiotics to kill or inhibit the growth of antibiotic resistant bacteria.", "FIG.", "9 is a graph that shows the impact on the growth curve of the EPEC kanamycin resistant strain when grown in the presence of: (i) kanamycin (line number 2 from top, (triangles)), (ii) Fe-QA (line number 1, from top), and (iii) kanamycin and Fe-QA (line number 3, from top (squares)).", "The most rapid growth was found when the strain was grown in medium only containing Fe-QA.", "However, a difference was observed between the rate of growth of the strain in the presence of kanamycin versus kanamycin and Fe-QA.", "The double-headed arrow indicates the difference in rates between these two growth conditions.", "The rate of growth of the strain was inhibited in the presence of kanamycin and Fe-Q relative to the rate of growth of the strain just in the presence of kanamycin.", "This is further evidence that Fe-QA can be used in conjunction with antibiotics to kill or inhibit the growth of antibiotic resistant bacteria.", "Example 10.Fe-QA Treatment Makes Antibiotic Resistant Strain of C. jejuni NCYC 11168 Lose Resistance to Antibiotic Materials and Methods A patch immersed in a solution of Fe-QA was placed on a growth plate with wildtype Campylobacter jejuni NCTC 11168 (that does not carry a kanamycin resistance gene).", "The wildtype C. jejuni grew normally, and was not affected by FeQ.", "A patch was also immersed in a solution of kanamycin and Fe-QA, and placed on a growth plate of wildtype C. jejuni.", "The growth of C. jejuni was impacted showing that wildtype C. jejuni is sensitive to the presence of kanamycin.", "The patch experiments were repeated with a Campylobacter jejuni NCTC 11168 strain carrying a kanamycin resistance gene wherein patches were immersed in (i) kanamycin only, (ii) Fe-QA only, and (iii) kanamycin and Fe-QA.", "The growth of the C. jejuni strain carrying the kanamycin resistance gene was not impacted by the patches immersed in (i) kanamycin and (ii) Fe-QA, however, the growth was impacted by the patch that was immersed in both kanamycin and Fe-QA.", "The results further demonstrate that Fe-QA can be used in combination with antibiotics to inhibit or kill antibiotic resistant bacteria.", "Example 11.Fe-Tyr Treatment Makes Antibiotic Resistant Strain of Enteropathogenic E. Coli (EPEC) E2348/69 Lose Resistance to Antibiotic Materials and Methods The impact on the growth curve of antibiotic resistant Enteropathogenic E. coli (EPEC) strain E2348/69 (genotype Wild Type EPEC O17:H6) when grown in the presence of (i) gentamicin (1.25 μM), (ii) Fe-Tyr (100 μM), (iii) gentamicin (1.25 μM) and Fe-Tyr (1.25 μM), and (iv) a control with no gentamicin or Fe-Tyr present was determined.", "Results FIG.", "10A is a graph that shows the impact on the growth curve of antibiotic resistant Enteropathogenic E. coli (EPEC) strain E2348/69 (genotype Wild Type EPEC O17:H6) when grown in the presence of (i) gentamicin (1.25 μM) (grey circles), (ii) Fe-Tyr (100 μM) (grey inverted triangles), (iii) gentamicin (1.25 μM) and Fe-Tyr (1.25 μM) (white upright triangles), and (iv) a control with no gentamicin or Fe-Tyr present (black circles).", "The most rapid growth (see FIG.", "10B) was found when the strain was grown in medium only containing Fe-Tyr, which was comparable to the control (without gentamicin or Fe-Tyr present).", "However, a difference was observed between the rate of growth of the strain in the presence of the antibiotic gentamicin versus gentamicin and Fe-Tyr.", "Thus it was shown that the rate of growth of the strain was inhibited in the presence of gentamicin and Fe-Tyr relative to the rate of growth of the strain just in the presence of gentamicin.", "This is evidence that Fe-Tyr can be used in conjunction with antibiotics to kill or inhibit the growth of antibiotic resistant bacteria.", "Example 12.FeQ (Known Also as “Fe-QA”) Treatment Makes Antibiotic Resistant Strain of Enteropathogenic E. Coli (EPEC) E2348/69 Lose Resistance to Antibiotic Materials and Methods The impact on the growth curve of antibiotic resistant Enteropathogenic E. coli (EPEC) strain E2348/69 (genotype Wild Type EPEC O17:H6) when grown in the presence of a fixed concentration of gentamicin (1.25 μM) and an increasing concentration of FeQ versus the strain grown in the presence of only FeQ or only gentamicin, was determined.", "Results FIGS.", "11A-C are graphs that show the impact on the growth curve of antibiotic resistant Enteropathogenic E. coli (EPEC) strain E2348/69 (genotype Wild Type EPEC O17:H6) when grown in the presence of a fixed concentration of gentamicin (1.25 μM) and an increasing concentration of FeQ (FIG.", "11A: 10 μM, FIG.", "11B: 34 μM and FIG.", "11C: 68 μM) versus the strain grown in the presence of only FeQ or only gentamicin.", "As shown in FIG.", "11D, increasing the concentration of FeQ from 10 μM to 100 μM did not impact the growth rate of the strain.", "However, FIG.", "11E clearly shows that a difference was observed between the rate of growth of the strain in the presence of the antibiotic gentamicin versus the combination of gentamicin and FeQ.", "Thus it was shown the rate of growth of the strain was inhibited in the presence of gentamicin and FeQ relative to the rate of growth of the strain just in the presence of gentamicin.", "This is further evidence that FeQ can be used in conjunction with antibiotics to kill or inhibit the growth of antibiotic resistant bacteria.", "Example 13.FeQ Prevents Attachment of Bacteria to Surfaces Materials and Methods Enteropathogenic E. coli (EPEC) E2348/69 were grown in wells for 48 hours at 37° C. in the presence of FeQ (100 μM), and in the absence of FeQ (as control).", "After 48 hours, the wells were washed in order to remove suspended cells.", "Crystal violet was then added to each well.", "The wells were then washed to remove excess dye.", "A mixture of acetone/ethanol was then added to the wells to re-suspend any cells attached to the plastic surface of the wells, and dissolve any dye present.", "The presence of dye in each well was then quantified by measuring the O.D.", "at 570 nm.", "Results In the absence of FeQ, EPEC binds to the plastic surface and forms a biofilm that is readily detected by dying with crystal violet.", "However, in the presence of FeQ, EPEC is unable to attach to the plastic surface and form a biofilm, and is not detected by adding crystal violet.", "FIG.", "12 shows quantitatively the difference in the attachment of EPEC cells to the plastic well surface in the absence and presence of FeQ by measurement of the optical absorbance of crystal violet that was absorbed by EPEC cells attached to the surface.", "At an FeQ concentration of 100 μM there is little or no attachment of bacterial cells to the surface and no biofilm formation.", "Example 14.FeQ (Known Also as “Fe-QA”) Treatment Makes Antibiotic Resistant Strain of Pseudomonas aeruginosa PAO-1 Lose Resistance to Antibiotic Materials and Methods The impact on the growth curve of an antibiotic resistant clinical isolate of Pseudomonas aeruginosa (PAO-1 Clinical) grown in the presence of kanamycin and FeQ versus the clinical isolate grown in the presence of (i) FeQ, (ii) kanamycin or (iii) without addition of FeQ or kanamycin (control) was assessed.", "Results FIG.", "13 is a graph that shows the impact on the growth curve of an antibiotic resistant clinical isolate of Pseudomonas (PAO-1 Clinical) grown in the presence of kanamycin and FeQ versus the clinical isolate grown in the presence of (i) FeQ, (ii) kanamycin or (iii) without addition of FeQ or kanamycin (control).", "The graph shows a large reduction in the growth rate of the Pseudomonas PAO clinical isolate when kanamycin and FeQ are added to the growth media versus either kanamycin or FeQ alone.", "The example demonstrates that FeQ causes the Pseudomonas clinical isolate to lose its sensitivity to the antibiotic.", "Example 15.Impact of FeQ and Mutation of the Glycosylation Site of the MOMP Protein of Campylobacter jejuni on Protein Expression Materials and Methods In order to determine the role of FeQ and glycosylation on protein expression by Campylobacter, a quantitative proteomic approach was undertaken to determine protein contents upon FeQ treatment of Campylobacter jejuni NCTC 11168 wildtype (WT) and a mutant strain (MOMPT268G), also referred to as MOMP-T, where the O-glycosylation site of MOMP had been disrupted by an amino acid substitution preventing glycosylation of MOMP.", "Protein expression of (i) Campylobacter jejuni 11168 wildtype (WT), (ii) Campylobacter jejuni 11168 MOMP-T (MOMP-T), (iii) Campylobacter jejuni 11168 wildtype (WT) in the presence of FeQ, and (iv) Campylobacter jejuni 11168 MOMP-T in the presence of FeQ were determined using isobaric tags for relative and absolute quantitation (iTRAQ).", "Bacterial proteins were identified using LC-MS/MS and iTRAQ, and functions assigned according to the Gene Ontology classification system.", "A total of 274,533 mass spectra from all samples led to the identification of 626 peptides (i.e.", "420 unique peptides that were assigned to 160 Campylobacter proteins).", "Results Table 1 shows the results of iTRAQ analysis comparing the ratios of protein expression for (a) WT/MOMP-T, (b) WT+FeQ/WT, (c) MOMP-T+FeQ/MOMP-T, and (d) WT+FeQ/MOMP-T+FeQ, wherein (a) is the ratio of Campylobacter jejuni 11168 wildtype to the Campylobacter jejuni 11168 T268G mutant, (b) is the ratio of Campylobacter jejuni 11168 wildtype treated with FeQ to Campylobacter jejuni 11168 wildtype, (c) is the ratio of the Campylobacter jejuni 11168 T268G mutant treated with FeQ to the Campylobacter jejuni 11168 T268G mutant, and (d) is the ratio of Campylobacter jejuni 11168 wildtype treated with FeQ to the Campylobacter jejuni 11168 T268G mutant treated with FeQ.", "TABLE 1 iTRAQ analysis WT + FeQ/ # Unique WT/MOMP-T WT + FeQ/WT MOMP-T + FeQ/MOMP-T MOMP-T + FeQ Accession Description MW [kDa] Coverage # Proteins Peptides # Peptides 114/116 115/114 117/116 115/117 A0A059H879 Molecular chaperone GroEL 57.9 56.51 30 20 24 0.821 1.460 1.222 1.082 OS = Campylobacter jejuni Cj1 GN = groEL PE = 4 SV = 1 − [A0A059H879_CAMJU] A3ZEC2 Elongation factor Tu 43.6 51.63 16 14 15 0.916 0.907 0.945 0.949 OS = Campylobacter jejuni subsp.", "jejuni HB93-13 GN = tuf PE = 3 SV = 1 − [A3ZEC2_CAMJU] H7YTU2 Putative GMC 63.7 27.23 34 11 12 1.494 1.476 1.319 1.894 oxidoreductase subunit OS = Campylobacter jejuni subsp.", "jejuni LMG 23357 GN = cje133_09008 PE = 4 SV = 1 − [H7YTU2_CAMJU] H7YEB5 Nickel-dependent 63.5 30.30 36 9 12 0.585 1.027 0.890 0.818 hydrogenase, large subunit OS = Campylobacter jejuni subsp.", "jejuni LMG 9879 GN = cje120_00450 PE = 3 SV = 1 − [H7YEB5_CAMJU] A0A059GL54 Cytochrome C biogenesis 36.8 34.90 18 9 11 1.162 0.694 0.778 1.118 protein CcsA OS = Campylobacter jejuni 255 GN = L034_08235 PE = 4 SV = 1 − [A0A059GL54_CAMJU] H7ZE54 Chemotaxis protein CheA 85.2 20.03 24 9 13 0.720 1.176 1.034 0.861 OS = Campylobacter jejuni subsp.", "jejuni 2008-1025 GN = cje145_01162 PE = 4 SV = 1 − [H7ZE54_CAMJU] E5Z9V4 Methyl-accepting chemotaxis 71.3 38.73 229 8 21 0.893 1.172 1.049 1.105 protein (MCP) signaling domain protein (Fragment) OS = Campylobacter jejuni subsp.", "jejuni DFVF1099 GN = CSQ_1786 PE = 4 SV = 1 − [E5Z9V4_CAMJU] A0A023WIW7 Fumarate reductase 73.7 19.76 30 8 11 0.865 0.832 0.766 0.992 flavoprotein subunit OS = Campylobacter jejuni subsp.", "jejuni CG8421 GN = CJ8421_02050 PE = 4 SV = 1 − [A0A023WIW7_CAMJU] W8JBW7 Cytochrome C 41.4 29.95 25 8 10 0.574 1.116 0.820 0.816 OS = Campylobacter jejuni subsp.", "jejuni NCTC 11168-Kf1 GN = N919_05910 PE = 4 SV = 1 − [W8JBW7_CAMJE] A8FJR2 ATP synthase subunit beta 50.8 20.65 14 7 8 0.718 1.106 0.942 1.019 OS = Campylobacter jejuni subsp.", "jejuni serotype O:6 (strain 81116/NCTC 11828) GN = atpD PE = 3 SV = 1 − [ATPB_CAMJ8] Q9PPE0 Probable thiol peroxidase 18.4 60.00 12 7 8 1.159 1.281 1.162 1.446 OS = Campylobacter jejuni subsp.", "jejuni serotype O:2 (strain NCTC 11168) GN = tpx PE = 3 SV = 1 − [TPX_CAMJE] E5ZFX0 Methyl-accepting chemotaxis 41.8 26.39 95 7 8 0.676 1.183 1.061 0.748 protein (MCP) signaling domain protein (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_2003 PE = 4 SV = 1 − [E5ZFX0_CAMJU] H7ZH37 Putative amino-acid 30.9 46.95 29 7 12 0.568 1.623 1.058 0.980 transporter periplasmic solute-binding protein OS = Campylobacter jejuni subsp.", "jejuni 2008-1025 GN = cje145_06564 PE = 4 SV = 1 − [H7ZH37_CAMJU] D2MUR2 Possible bacterioferritin 17.2 69.80 14 7 9 0.766 1.045 0.951 0.939 OS = Campylobacter jejuni subsp.", "jejuni 1336 GN = C1336_000320070 PE = 3 SV = 1 − [D2MUR2_CAMJU] H8BN80 Methyl-accepting chemotaxis 76.1 21.16 79 6 10 0.702 1.106 1.005 0.857 protein (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 87459 GN = cje34_06680 PE = 4 SV = 1 − [H8BN80_CAMJU] W8J4X8 Chemotaxis protein 72.3 36.42 189 6 20 0.873 1.095 1.015 0.994 OS = Campylobacter jejuni subsp.", "jejuni NCTC 11168-Kf1 GN = N919_00720 PE = 4 SV = 1 − [W8J4X8_CAMJE] A0A059H748 Formate dehydrogenase 82.3 12.08 36 6 7 1.311 0.622 0.795 1.077 OS = Campylobacter jejuni Cj2 GN = N215_08730 PE = 4 SV = 1 − [A0A059H748_CAMJU] A0A059GQU9 Cytochrome C 69.2 15.90 39 6 8 0.785 0.882 0.892 0.817 OS = Campylobacter jejuni 255 GN = L034_04325 PE = 4 SV = 1 − [A0A059GQU9_CAMJU] Q9PI32 50S ribosomal protein L7/L12 13.1 48.00 12 5 5 0.555 1.156 0.899 0.849 OS = Campylobacter jejuni subsp.", "jejuni serotype O:2 (strain NCTC 11168) GN = rplL PE = 3 SV = 1 − [RL7_CAMJE] N4Y7C8 ATP synthase subunit alpha 52.0 20.21 26 5 9 0.943 0.985 1.042 1.145 OS = Campylobacter jejuni subsp.", "jejuni ICDCCJ07004 GN = atpA PE = 3 SV = 1 − [N4Y7C8_CAMJU] W2ANI8 Chemotaxis protein 70.2 35.36 175 5 19 0.557 1.240 0.923 0.655 (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 81-176- UMCW7 GN = X909_03500 PE = 4 SV = 1 − [W2ANI8_CAMJJ] A0A059GKB1 Uncharacterized protein 20.5 42.63 20 5 7 1.416 0.969 0.688 2.228 OS = Campylobacter jejuni 30286 GN = N196_05010 PE = 4 SV = 1 − [A0A059GKB1_CAMJU] E5Z8A4 PPIC-type PPIASE domain 29.4 29.66 23 5 7 1.657 1.318 1.852 1.268 protein OS = Campylobacter jejuni subsp.", "jejuni DFVF1099 GN = CSQ_1024 PE = 4 SV = 1 − [E5Z8A4_CAMJU] E5ZDN6 Periplasmic nitrate 99.4 13.13 23 5 10 1.247 0.694 0.745 1.406 reductase, large subunit (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = napA PE = 3 SV = 1 − [E5ZDN6_CAMJU] A0A059GE96 Inosine-5-monophosphate 52.1 23.09 28 5 8 1.060 1.048 1.203 0.976 dehydrogenase OS = Campylobacter jejuni 10186 GN = N194_07695 PE = 4 SV = 1 − [A0A059GE96_CAMJU] A0A059GIX6 Pyruvate-flavodoxin 131.3 6.32 34 5 6 1.155 0.905 0.998 1.104 oxidoreductase OS = Campylobacter jejuni 10186 GN = N194_00565 PE = 4 SV = 1 − [A0A059GIX6_CAMJU] A0A059H231 DNA-directed RNA 155.5 4.29 34 5 5 1.143 1.013 1.208 1.014 polymerase subunit beta OS = Campylobacter jejuni Cj5 GN = N213_08515 PE = 4 SV = 1 − [A0A059H231_CAMJU] Q3HR22 Putative ATP/GTP binding 33.8 23.76 33 5 6 0.551 1.156 0.934 0.700 protein (Fragment) OS = Campylobacter jejuni PE = 4 SV = 1 − [Q3HR22_CAMJU] A8FNQ7 DNA-directed RNA 37.7 18.10 10 4 6 0.858 0.993 0.931 1.056 polymerase subunit alpha OS = Campylobacter jejuni subsp.", "jejuni serotype O:6 (strain 81116/NCTC 11828) GN = rpoA PE = 3 SV = 1 − [RPOA_CAMJ8] D3FK01 Alkyl hydroperoxide reductase 22.0 36.87 6 4 5 1.141 1.110 1.085 1.255 OS = Campylobacter jejuni subsp.", "jejuni (strain IA3902) GN = ahpC PE = 4 SV = 1 − [D3FK01_CAMJI] A0A059GHU6 Lipoprotein 17.8 33.94 10 4 5 0.520 1.095 0.681 0.994 OS = Campylobacter jejuni 30286 GN = N196_08005 PE = 4 SV = 1 − [A0A059GHU6_CAMJU] H8BUP1 Putative oxidoreductase 26.0 25.64 14 4 4 1.497 1.388 1.418 1.468 subunit OS = Campylobacter jejuni subsp.", "jejuni 140-16 GN = cje4_08690 PE = 4 SV = 1 − [H8BUP1_CAMJU] A0A059GU70 Serine protease 51.0 15.04 31 4 6 1.548 1.469 1.572 1.562 OS = Campylobacter jejuni 30318 GN = N212_01200 PE = 4 SV = 1 − [A0A059GU70_CAMJU] D3FN39 Bipartate energy taxis 19.3 24.85 19 4 4 0.375 2.172 1.256 0.740 response protein cetB OS = Campylobacter jejuni subsp.", "jejuni (strain IA3902) GN = cetB PE = 4 SV = 1 − [D3FN39_CAMJI] A0A059I201 Chemotaxis protein CheY 34.8 18.77 15 4 4 0.820 1.034 0.965 0.955 (Fragment) OS = Campylobacter jejuni K5 GN = N218_00260 PE = 4 SV = 1 − [A0A059I201_CAMJU] E5ZAL2 Ketol-acid reductoisomerase 36.7 16.27 24 3 4 0.851 1.126 1.009 1.019 OS = Campylobacter jejuni subsp.", "jejuni 305 GN = ilvC PE = 3 SV = 1 − [E5ZAL2_CAMJU] H7Y518 Major outer membrane 45.6 30.90 215 3 10 0.109 0.832 0.840 0.121 protein OS = Campylobacter jejuni subsp.", "jejuni LMG 23269 GN = cje114_01222 PE = 4 SV = 1 − [H7Y518_CAMJU] D6BWG0 Fibronectin-binding protein 23.4 17.54 32 3 4 0.478 1.008 0.784 0.678 (Fragment) OS = Campylobacter jejuni GN = cadF PE = 3 SV = 1 − [D6BWG0_CAMJU] N4Y4W1 Fumarate reductase iron-sulfur 24.9 24.77 11 3 4 0.737 0.776 0.716 0.868 subunit OS = Campylobacter jejuni subsp.", "jejuni ICDCCJ07004 GN = H741_1738 PE = 4 SV = 1 − [N4Y4W1_CAMJU] A0A059HYE2 50S ribosomal protein L5 19.7 26.55 16 3 4 0.880 0.878 1.078 0.736 (Fragment) OS = Campylobacter jejuni K5 GN = N218_12355 PE = 4 SV = 1 − [A0A059HYE2_CAMJU] T2D4H6 Nitrogen fixation protein NifU 32.4 19.73 22 3 5 1.099 1.379 1.207 1.364 OS = Campylobacter jejuni subsp.", "jejuni 00-2544 GN = N755_00276 PE = 3 SV = 1 − [T2D4H6_CAMJU] H7X7T5 Non-heme iron protein 17.0 48.99 17 3 6 1.198 0.956 0.748 1.957 OS = Campylobacter jejuni subsp.", "jejuni 51494 GN = cje10_07457 PE = 4 SV = 1 − [H7X7T5_CAMJU] A0A059I263 50S ribosomal protein L13 15.7 30.50 9 3 4 0.784 0.864 0.928 0.765 OS = Campylobacter jejuni K5 GN = N218_00710 PE = 4 SV = 1 − [A0A059I263_CAMJU] A0A059GLY8 O-acetylhomoserine 46.6 10.64 25 3 3 0.531 1.165 1.089 0.666 aminocarboxypropyltransferase OS = Campylobacter jejuni 30286 GN = N196_03230 PE = 4 SV = 1 − [A0A059GLY8_CAMJU] E5ZGX0 30S ribosomal protein S1 60.1 6.58 39 3 3 1.167 0.899 0.966 1.180 OS = Campylobacter jejuni subsp.", "jejuni 327 GN = CSU_0110 PE = 3 SV = 1 − [E5ZGX0_CAMJU] A0A059HDM4 Ferritin OS = Campylobacter 19.5 28.74 7 3 4 0.679 1.225 1.263 0.729 jejuni Cj1 GN = N214_07950 PE = 4 SV = 1 − [A0A059HDM4_CAMJU] A0A059H490 Capsule biosynthesis protein 42.5 9.68 37 3 3 0.848 1.123 1.000 1.034 OS = Campylobacter jejuni 30318 GN = N212_06885 PE = 4 SV = 1 − [A0A059H490_CAMJU] A0A059H487 Cytochrome Cbb3 31.1 12.54 14 3 3 0.605 0.898 0.814 0.799 OS = Campylobacter jejuni Cj5 GN = N213_05015 PE = 4 SV = 1 − [A0A059H487_CAMJU] A0A059H9K5 Uncharacterized protein 16.1 24.31 21 3 3 1.324 1.130 1.047 1.527 OS = Campylobacter jejuni Cj1 GN = N214_00085 PE = 4 SV = 1 − [A0A059H9K5_CAMJU] E6RSV9 Putative periplasmic protein 26.4 21.03 39 3 4 0.734 1.145 1.044 0.897 OS = Campylobacter jejuni subsp.", "jejuni (strain S3) GN = CJS3_0034 PE = 4 SV = 1 − [E6RSV9_CAMJS] H7ZHL3 Thioredoxin 11.3 39.42 3 3 3 1.049 1.096 1.010 1.208 OS = Campylobacter jejuni subsp.", "jejuni 2008-1025 GN = cje145_07496 PE = 3 SV = 1 − [H7ZHL3_CAMJU] A5KGI0 Trigger factor 50.9 9.26 32 3 4 1.196 0.959 1.622 0.690 OS = Campylobacter jejuni subsp.", "jejuni CG8486 GN = tig PE = 3 SV = 1 − [A5KGI0_CAMJU] A1VYF9 Acyl carrier protein 8.6 44.16 5 2 3 0.834 1.042 0.962 0.954 OS = Campylobacter jejuni subsp.", "jejuni serotype O:23/36 (strain 81-176) GN = acpP PE = 3 SV = 1 − [ACP_CAMJJ] A7H623 Protein RecA 37.0 8.75 13 2 2 0.333 0.827 1.507 0.199 OS = Campylobacter jejuni subsp.", "doylei (strain ATCC BAA-1458/RM4099/269.97) GN = recA PE = 3 SV = 1 − [RECA_CAMJD] A7H646 50S ribosomal protein L14 13.3 15.57 4 2 2 1.392 0.788 1.197 0.996 OS = Campylobacter jejuni subsp.", "doylei (strain ATCC BAA-1458/RM4099/269.97) GN = rplN PE = 3 SV = 1 − [RL14_CAMJD] A8FJQ0 50S ribosomal protein L27 9.3 32.14 4 2 2 0.427 0.991 0.987 0.466 OS = Campylobacter jejuni subsp.", "jejuni serotype O:6 (strain 81116/NCTC 11828) GN = rpmA PE = 3 SV = 1 − [RL27_CAMJ8] A0A059GI82 Preprotein translocase subunit 98.0 2.67 39 2 2 1.461 1.058 1.347 1.299 SecA OS = Campylobacter jejuni 10186 GN = N194_01400 PE = 4 SV = 1 − [A0A059GI82_CAMJU] R4VJ36 Methyl-accepting chemotaxis 40.5 9.89 68 2 3 1.356 0.726 0.954 1.120 protein (Fragment) OS = Campylobacter jejuni PE = 4 SV = 1 − [R4VJ36_CAMJU] E5ZGP1 Translation initiation factor IF- 74.4 3.52 45 2 2 1.518 0.950 1.416 1.106 2 (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = infB PE = 3 SV = 1 − [E5ZGP1_CAMJU] A0A059HWV0 Molecular chaperone DnaK 44.2 6.80 30 2 2 1.115 1.065 1.140 1.161 (Fragment) OS = Campylobacter jejuni K5 GN = dnaK PE = 4 SV = 1 − [A0A059HWV0_CAMJU] D2MY32 DNA-binding protein HU 10.3 58.16 7 2 4 0.523 1.053 0.764 0.782 OS = Campylobacter jejuni subsp.", "jejuni 414 GN = C414_000220094 PE = 3 SV = 1 − [D2MY32_CAMJU] E5Z911 10 kDa chaperonin (Fragment) 8.5 33.33 11 2 2 0.833 1.334 1.307 0.937 OS = Campylobacter jejuni subsp.", "jejuni DFVF1099 GN = CSQ_1483 PE = 3 SV = 1 − [E5Z911_CAMJU] A5KF33 DNA-directed RNA 71.4 5.35 39 2 3 1.072 0.852 1.198 0.829 polymerase OS = Campylobacter jejuni subsp.", "jejuni CG8486 GN = Cj8486_0470 PE = 3 SV = 1 − [A5KF33_CAMJU] A0A059GK15 Chemotaxis protein CheY 25.5 10.76 11 2 2 1.082 1.172 0.861 1.497 OS = Campylobacter jejuni 30286 GN = N196_06275 PE = 4 SV = 1 − [A0A059GK15_CAMJU] H7X9T0 Putative periplasmic 10.8 26.00 9 2 3 2.195 0.784 0.518 3.608 cytochrome C OS = Campylobacter jejuni subsp.", "jejuni LMG 23216 GN = cje100_00683 PE = 4 SV = 1 − [H7X9T0_CAMJU] H8A1L3 Succinyl-CoA ligase [ADP- 41.8 10.85 31 2 4 1.598 0.731 0.879 1.443 forming] subunit beta OS = Campylobacter jejuni subsp.", "jejuni 1997-1 GN = sucC PE = 3 SV = 1 − [H8A1L3_CAMJU] E5ZK16 Aspartate ammonia-lyase 51.5 18.24 28 2 7 2.064 0.774 1.001 1.821 OS = Campylobacter jejuni subsp.", "jejuni 327 GN = aspA PE = 4 SV = 1 − [E5ZK16_CAMJU] H8AV03 Flavodoxin 17.1 46.63 15 2 5 0.869 1.453 0.941 1.505 OS = Campylobacter jejuni subsp.", "jejuni 1997-11 GN = cje23_01298 PE = 3 SV = 1 − [H8AV03_CAMJU] E6S147 Heat shock protein HtpG 43.4 8.49 38 2 2 1.211 0.971 1.132 1.129 OS = Campylobacter jejuni subsp.", "jejuni serotype HS:41 (strain ICDCCJ07001) GN = ICDCCJ07001_468 PE = 4 SV = 1 − [E6S147_CAMJC] T2DA57 Biotin sulfoxide reductase 83.5 4.83 24 2 3 1.297 0.947 1.394 0.957 OS = Campylobacter jejuni subsp.", "jejuni 00-2538 GN = N565_00245 PE = 3 SV = 1 − [T2DA57_CAMJU] W2AJL6 Hemolysin D 35.9 7.29 29 2 2 0.923 1.075 1.067 1.011 OS = Campylobacter jejuni subsp.", "jejuni 81-176-DRH212 GN = X908_07140 PE = 4 SV = 1 − [W2AJL6_CAMJJ] A0A059HWP5 50S ribosomal protein L6 19.6 13.48 11 2 2 0.685 0.939 0.944 0.740 OS = Campylobacter jejuni 20176 GN = N195_02450 PE = 4 SV = 1 − [A0A059HWP5_CAMJU] A0A059I3A1 Bifunctional aconitate 68.5 7.91 41 2 4 1.215 1.015 0.960 1.395 hydratase 2/2-methylisocitrate dehydratase (Fragment) OS = Campylobacter jejuni K5 GN = N218_00085 PE = 4 SV = 1 − [A0A059I3A1_CAMJU] E5Z763 Histidine-binding protein 16.6 12.00 25 2 2 0.536 1.228 0.916 0.781 OS = Campylobacter jejuni subsp.", "jejuni DFVF1099 GN = CSQ_0818 PE = 4 SV = 1 − [E5Z763_CAMJU] N4Y795 Periplasmic nitrate reductase, 18.5 23.08 14 2 2 1.045 0.800 0.679 1.337 electron transfer subunit OS = Campylobacter jejuni subsp.", "jejuni ICDCCJ07004 GN = H741_0553 PE = 3 SV = 1 − [N4Y795_CAMJU] E5ZDN8 Major antigenic peptide PEB2 23.4 11.06 24 2 2 1.820 0.919 1.187 1.624 OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_1183 PE = 4 SV = 1 − [E5ZDN8_CAMJU] A0A023WJ10 Multifunctional 53.7 7.87 41 2 3 2.246 0.792 1.851 1.044 aminopeptidase A OS = Campylobacter jejuni subsp.", "jejuni CG8421 GN = CJ8421_04595 PE = 4 SV = 1 − [A0A023WJ10_CAMJU] E5Z8E0 Ubiquinol-cytochrome c 17.0 26.75 18 2 3 0.661 1.010 0.843 0.861 reductase, iron-sulfur subunit OS = Campylobacter jejuni subsp.", "jejuni DFVF1099 GN = petA PE = 4 SV = 1 − [E5Z8E0_CAMJU] A3ZFB9 Protein TolB (Fragment) 37.1 7.51 20 2 2 1.168 0.974 1.030 1.200 OS = Campylobacter jejuni subsp.", "jejuni HB93-13 GN = CJJHB9313_0128 PE = 4 SV = 1 − [A3ZFB9_CAMJU] E5ZCI8 Cytochrome c oxidase, cbb3- 21.0 15.14 11 2 2 0.654 0.917 0.830 0.766 type, subunit II (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = ccoO PE = 4 SV = 1 − [E5ZCI8_CAMJU] E5ZDB1 UDP-N-acetylglucosamine 1- 43.3 6.47 29 2 2 1.339 0.913 1.188 1.119 carboxyvinyltransferase (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = murA PE = 3 SV = 1 − [E5ZDB1_CAMJU] A8FP13 50S ribosomal protein L29 7.0 11.48 4 1 1 OS = Campylobacter jejuni subsp.", "jejuni serotype O:6 (strain 81116/NCTC 11828) GN = rpmC PE = 3 SV = 1 − [RL29_CAMJ8] A7H1N3 50S ribosomal protein L31 7.3 15.38 4 1 1 1.075 0.960 1.247 0.899 OS = Campylobacter jejuni subsp.", "doylei (strain ATCC BAA-1458/RM4099/269.97) GN = rpmE PE = 3 SV = 1 − [RL31_CAMJD] E7G1N6 30S ribosomal protein S12 13.4 13.93 6 1 2 1.278 0.572 0.758 1.051 OS = Campylobacter jejuni subsp.", "jejuni DFVF1099 GN = rpsL PE = 3 SV = 1 − [E7G1N6_CAMJU] E5ZKB7 Methyl-accepting chemotaxis 66.0 3.42 77 1 2 1.419 1.018 1.069 1.467 protein (MCP) signaling domain protein OS = Campylobacter jejuni subsp.", "jejuni 327 GN = CSU_1383 PE = 4 SV = 1 − [E5ZKB7_CAMJU] H7Y9X9 50S ribosomal protein L25 19.5 12.36 8 1 2 OS = Campylobacter jejuni subsp.", "jejuni 55037 GN = rplY PE = 3 SV = 1 − [H7Y9X9_CAMJU] E5Z7S7 HAD-superfamily hydrolase, 114.6 1.54 2 1 1 1.275 0.867 1.201 1.000 subfamily IA, variant 1 family protein OS = Campylobacter jejuni subsp.", "jejuni DFVF1099 GN = CSQ_1071 PE = 4 SV = 1 − [E5Z7S7_CAMJU] A0A059HMD1 Membrane protein 45.7 23.29 114 1 8 0.224 0.963 0.840 0.279 OS = Campylobacter jejuni Cj2 GN = N215_00405 PE = 4 SV = 1 − [A0A059HMD1_CAMJU] A0A059GML6 Thiamine biosynthesis 47.4 2.33 29 1 1 1.462 0.787 1.142 1.095 protein ThiC OS = Campylobacter jejuni 255 GN = L034_06270 PE = 4 SV = 1 − [A0A059GML6_CAMJU] A0A059GQ49 NADH dehydrogenase 24.9 6.57 8 1 1 0.793 0.891 0.886 0.866 OS = Campylobacter jejuni 10186 GN = N194_04245 PE = 4 SV = 1 − [A0A059GQ49_CAMJU] D2MZ94 Fibronectin type III domain 45.2 3.74 26 1 2 protein OS = Campylobacter jejuni subsp.", "jejuni 414 GN = C414_000260115 PE = 4 SV = 1 − [D2MZ94_CAMJU] A0A059HT33 30S ribosomal protein S6 12.5 6.60 9 1 1 0.857 1.009 1.187 0.792 (Fragment) OS = Campylobacter jejuni K5 GN = N218_16365 PE = 4 SV = 1 − [A0A059HT33_CAMJU] A0A059HR90 Superoxide dismutase 24.8 14.09 15 1 3 OS = Campylobacter jejuni K1 GN = N217_00445 PE = 4 SV = 1 − [A0A059HR90_CAMJU] H7ZK03 ATP-dependent chaperone 31.6 7.39 49 1 2 1.019 1.107 1.339 0.915 protein ClpB (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 2008-894 GN = cje146_02596 PE = 4 SV = 1 − [H7ZK03_CAMJU] I6YES0 Flagellin A (Fragment) 58.9 22.24 355 1 10 0.477 0.897 0.908 0.512 OS = Campylobacter jejuni GN = flaA PE = 4 SV = 1 − [I6YES0_CAMJU] H7QVG3 DNA-binding response 34.4 2.03 2 1 1 3.811 0.308 1.290 0.990 regulator, putative OS = Campylobacter coli 111- 3 GN = cco1_05089 PE = 4 SV = 1 − [H7QVG3_CAMCO] A0A059HJZ0 Uncharacterized protein 13.9 13.22 9 1 1 1.048 0.911 1.037 1.000 OS = Campylobacter jejuni Cj2 GN = N215_00975 PE = 4 SV = 1 − [A0A059HJZ0_CAMJU] A3YTA0 Ribosomal protein L3 18.6 10.00 9 1 2 0.614 0.838 0.685 0.816 (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 260.94 GN = rplC PE = 4 SV = 1 − [A3YTA0_CAMJU] A3ZGX1 Flagellin subunit protein 59.2 19.06 241 1 8 2.832 0.535 0.869 1.896 FlaB OS = Campylobacter jejuni subsp.", "jejuni 84-25 GN = flaB PE = 4 SV = 1 − [A3ZGX1_CAMJU] H7QW70 RNA polymerase sigma factor 72.7 1.13 16 1 1 1.195 1.023 1.175 1.130 RpoD OS = Campylobacter coli 111-3 GN = rpoD PE = 3 SV = 1 − [H7QW70_CAMCO] A0A059GGJ8 Aspartate ammonia-lyase 51.7 19.23 11 1 8 2.534 0.638 0.947 1.855 OS = Campylobacter jejuni 10186 GN = aspA PE = 4 SV = 1 − [A0A059GGJ8_CAMJU] A0A059GN06 50S ribosomal protein L1 25.0 10.30 4 1 2 0.724 1.063 0.790 1.058 OS = Campylobacter jejuni 255 GN = L034_06405 PE = 4 SV = 1 − [A0A059GN06_CAMJU] A0A023WJ77 2-oxoglutarate-acceptor 41.1 10.96 20 1 2 1.317 1.251 1.456 1.230 oxidoreductase subunit OorA OS = Campylobacter jejuni subsp.", "jejuni CG8421 GN = oorA PE = 4 SV = 1 − [A0A023WJ77_CAMJU] H7XU40 Putative transmembrane 30.7 9.71 32 1 3 protein OS = Campylobacter jejuni subsp.", "jejuni 60004 GN = cje11_00070 PE = 4 SV = 1 − [H7XU40_CAMJU] H7XPE7 Uncharacterized protein 28.2 2.81 27 1 1 0.602 1.000 0.949 0.689 OS = Campylobacter jejuni subsp.", "jejuni LMG 23263 GN = cje109_01311 PE = 4 SV = 1 − [H7XPE7_CAMJU] H7YV89 Uncharacterized protein 14.7 7.20 27 1 1 0.825 0.963 0.972 0.888 (Fragment) OS = Campylobacter jejuni subsp.", "jejuni ATCC 33560 GN = cje135_02523 PE = 4 SV = 1 − [H7YV89_CAMJU] A0A059HSX2 Membrane protein 17.7 6.04 11 1 1 0.672 1.062 0.884 0.877 OS = Campylobacter jejuni 20176 GN = N195_04100 PE = 4 SV = 1 − [A0A059HSX2_CAMJU] A5KI22 ATP synthase F1 sector 27.7 12.81 22 1 3 0.666 1.217 0.853 1.033 gamma subunit OS = Campylobacter jejuni subsp.", "jejuni CG8486 GN = Cj8486_0101 PE = 4 SV = 1 − [A5KI22_CAMJU] A0A059I444 Branched-chain amino acid 32.7 6.80 18 1 2 aminotransferase (Fragment) OS = Campylobacter jejuni K5 GN = N218_11890 PE = 4 SV = 1 − [A0A059I444_CAMJU] E5ZGJ6 Delta-aminolevulinic acid 34.3 2.89 27 1 1 dehydratase OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_2245 PE = 3 SV = 1 − [E5ZGJ6_CAMJU] E5ZFV6 Fibronectin type III domain 28.2 8.40 43 1 2 2.266 0.906 0.963 2.318 protein (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_1989 PE = 4 SV = 1 − [E5ZFV6_CAMJU] A0A059GNV7 2-oxoglutarate ferredoxin 31.2 4.27 14 1 1 1.156 1.022 1.005 1.276 oxidoreductase subunit beta OS = Campylobacter jejuni 10186 GN = N194_05915 PE = 4 SV = 1 − [A0A059GNV7_CAMJU] A5KFW1 Membrane bound zinc 40.7 7.55 20 1 2 1.000 0.979 1.086 0.979 metallopeptidase OS = Campylobacter jejuni subsp.", "jejuni CG8486 GN = Cj8486_1154c PE = 3 SV = 1 − [A5KFW1_CAMJU] H8A911 Putative endonuclease 64.2 1.65 9 1 1 (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 2008-979 GN = cje160_10022 PE = 4 SV = 1 − [H8A911_CAMJU] X0N637 30S ribosomal protein S15 10.0 10.23 4 1 1 0.180 0.759 1.075 0.138 OS = Campylobacter jejuni X GN = rpsO PE = 3 SV = 1 − [X0N637_CAMJU] Q29XU5 50S ribosomal protein L15 11.4 10.58 13 1 1 0.464 1.015 0.568 0.901 (Fragment) OS = Campylobacter jejuni GN = rpsLO PE = 3 SV = 1 − [Q29XU5_CAMJU] A0A059HZ15 30S ribosomal protein S5 13.3 9.45 4 1 1 0.374 1.290 0.833 0.629 (Fragment) OS = Campylobacter jejuni K5 GN = N218_07570 PE = 4 SV = 1 − [A0A059HZ15_CAMJU] A0A059GK29 Uncharacterized protein 21.0 14.21 15 1 2 OS = Campylobacter jejuni 30286 GN = N196_05955 PE = 4 SV = 1 − [A0A059GK29_CAMJU] E1PQD5 Transcription termination 38.8 3.16 11 1 1 0.856 1.519 1.405 1.005 factor Rho OS = Campylobacter jejuni subsp.", "jejuni serotype HS21 (strain M1/99/308) GN = rho PE = 3 SV = 1 − [E1PQD5_CAMJM] A0A059GFH4 7-alpha-hydroxysteroid 28.1 8.49 23 1 2 1.528 0.847 1.582 0.888 dehydrogenase OS = Campylobacter jejuni 255 GN = L034_05345 PE = 4 SV = 1 − [A0A059GFH4_CAMJU] W2AH04 50S ribosomal protein L21 10.4 10.53 9 1 1 0.584 1.000 0.737 0.861 OS = Campylobacter jejuni subsp.", "jejuni 81-176-DRH212 GN = X908_06720 PE = 3 SV = 1 − [W2AH04_CAMJJ] D2MWN2 Uncharacterized protein 8.9 11.84 2 1 1 1.634 1.000 1.134 1.566 OS = Campylobacter jejuni subsp.", "jejuni 414 GN = C414_000040068 PE = 4 SV = 1 − [D2MWN2_CAMJU] A0A059H8K1 Ubiquinol cytochrome C 48.1 2.40 10 1 1 0.689 0.984 0.821 0.897 oxidoreductase OS = Campylobacter jejuni Cj1 GN = N214_01665 PE = 4 SV = 1 − [A0A059H8K1_CAMJU] W2U6P5 Uncharacterized protein 5.8 19.23 22 1 1 OS = Campylobacter jejuni subsp.", "jejuni 81-176-UMCW9 GN = X910_08590 PE = 4 SV = 1 − [W2U6P5_CAMJJ] E5ZLJ7 3-dehydroquinate dehydratase 17.2 6.41 8 1 1 1.063 0.892 1.114 0.838 OS = Campylobacter jejuni subsp.", "jejuni 327 GN = aroQ PE = 3 SV = 1 − [E5ZLJ7_CAMJU] A3YNF7 Oxaloacetate decarboxylase, 65.8 2.50 16 1 1 1.673 0.966 1.200 1.463 alpha subunit, putative OS = Campylobacter jejuni subsp.", "jejuni CF93-6 GN = CJJCF936_1007 PE = 4 SV = 1 − [A3YNF7_CAMJU] Q29VV8 Putative nucleotidyl sugar 28.5 8.27 15 1 2 epimerase OS = Campylobacter jejuni subsp.", "jejuni serotype O:23/36 (strain 81-176) GN = CJB1426c PE = 4 SV = 1 − [Q29VV8_CAMJJ] A0A059I1M1 30S ribosomal protein S7 15.0 9.02 5 1 1 0.704 1.048 0.835 0.961 (Fragment) OS = Campylobacter jejuni K5 GN = N218_01130 PE = 4 SV = 1 − [A0A059I1M1_CAMJU] W2AGH3 Fur family transcriptional 8.8 13.92 7 1 1 1.333 1.021 1.255 1.178 regulator OS = Campylobacter jejuni subsp.", "jejuni 81-176- DRH212 GN = X908_06930 PE = 4 SV = 1 − [W2AGH3_CAMJJ] E5ZEC9 Methionyl-tRNA synthetase 9.7 13.41 45 1 1 2.302 0.862 1.589 1.380 (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_1425 PE = 4 SV = 1 − [E5ZEC9_CAMJU] Q001V3 Putative cytochrome C-type 17.3 7.33 13 1 1 0.902 1.006 1.038 0.951 haem-binding periplasmic protein (Fragment) OS = Campylobacter jejuni PE = 4 SV = 1 − [Q001V3_CAMJU] E5ZBV9 30S ribosomal protein S8 6.0 22.64 8 1 1 0.718 0.827 0.960 0.672 (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_0466 PE = 4 SV = 1 − [E5ZBV9_CAMJU] A5KH24 Glutamate-1-semialdehyde 2,1- 44.3 2.69 27 1 1 1.252 0.933 0.921 1.378 aminomutase OS = Campylobacter jejuni subsp.", "jejuni CG8486 GN = hemL PE = 1 SV = 1 − [A5KH24_CAMJU] A0A023WHY9 Succinyl-CoA synthase, alpha 30.0 9.69 15 1 2 1.069 0.851 0.923 1.071 subunit OS = Campylobacter jejuni subsp.", "jejuni CG8421 GN = CJ8421_02610 PE = 4 SV = 1 − [A0A023WHY9_CAMJU] A0A023WJZ2 Bifunctional adhesin/ABC 28.2 4.25 25 1 1 1.215 0.799 0.747 1.412 transporter aspartate/glutamate-binding protein OS = Campylobacter jejuni subsp.", "jejuni CG8421 GN = CJ8421_04555 PE = 4 SV = 1 − [A0A023WJZ2_CAMJU] E5ZG55 Nucleoside diphosphate kinase 11.4 10.68 11 1 1 OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_2085 PE = 3 SV = 1 − [E5ZG55_CAMJU] A0A059HYD1 Enolase (Fragment) 36.6 3.53 33 1 1 OS = Campylobacter jejuni K5 GN = eno PE = 4 SV = 1 − [A0A059HYD1_CAMJU] A3YPW8 Uncharacterized protein 13.1 10.17 18 1 1 (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 260.94 GN = CJJ26094_1432 PE = 4 SV = 1 − [A3YPW8_CAMJU] A0A059GQ16 50S ribosomal protein L16 16.3 8.51 4 1 1 OS = Campylobacter jejuni 10186 GN = N194_05010 PE = 4 SV = 1 − [A0A059GQ16_CAMJU] E6RY61 Cytochrome c biogenesis 43.7 3.45 41 1 1 1.247 1.052 1.234 1.154 protein, CcmF/CycK/CcsA family OS = Campylobacter jejuni subsp.", "jejuni serotype HS:41 (strain ICDCCJ07001) GN = ICDCCJ07001_974 PE = 4 SV = 1 − [E6RY61_CAMJC] A5KHZ1 Uncharacterized protein 33.8 4.03 24 1 1 2.039 0.831 0.889 2.072 OS = Campylobacter jejuni subsp.", "jejuni CG8486 GN = Cj8486_0065 PE = 4 SV = 1 − [A5KHZ1_CAMJU] A0A059GQV0 Flagellar basal body protein 19.9 6.18 11 1 1 0.539 1.269 0.875 0.850 FliL OS = Campylobacter jejuni 255 GN = L034_04560 PE = 4 SV = 1 − [A0A059GQV0_CAMJU] E5ZIW7 Elongation factor P 20.5 7.07 8 1 1 OS = Campylobacter jejuni subsp.", "jejuni 327 GN = efp PE = 3 SV = 1 − [E5ZIW7_CAMJU] A1VX93 Membrane protein, putative, 10.8 13.98 9 1 1 0.478 1.120 1.284 0.453 degenerate OS = Campylobacter jejuni subsp.", "jejuni serotype O:23/36 (strain 81-176) GN = CJJ81176_0041 PE = 4 SV = 1 − [A1VX93_CAMJJ] A0A059GDI2 Membrane protein 35.6 8.33 12 1 2 0.808 1.432 0.862 1.459 OS = Campylobacter jejuni 30286 GN = N196_02850 PE = 4 SV = 1 − [A0A059GDI2_CAMJU] A1VXK7 Uncharacterized protein 33.7 8.74 20 1 2 OS = Campylobacter jejuni subsp.", "jejuni serotype O:23/36 (strain 81-176) GN = CJJ81176_0159 PE = 4 SV = 1 − [A1VXK7_CAMJJ] E5ZAK6 Glucosamine-fructose-6- 25.0 5.88 31 1 1 1.599 1.108 1.171 1.644 phosphate aminotransferase OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_0017 PE = 4 SV = 1 − [E5ZAK6_CAMJU] E5ZDP4 Amino-acid ABC transporter 22.0 6.74 22 1 1 1.000 1.001 0.965 1.127 ATP-binding protein YecC (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_1189 PE = 3 SV = 1 − [E5ZDP4_CAMJU] E5ZBA2 50S ribosomal protein L4 18.6 8.77 17 1 1 (BL4) (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_0286 PE = 4 SV = 1 − [E5ZBA2_CAMJU] Q9R5T9 PEB2 = MAJOR antigenic 3.7 42.86 1 1 1 peptide (Fragment) OS = Campylobacter jejuni PE = 1 SV = 1 − [Q9R5T9_CAMJU] E5ZIC4 4-oxalocrotonate tautomerase 7.5 20.59 4 1 1 family enzyme family protein OS = Campylobacter jejuni subsp.", "jejuni 327 GN = dmpI PE = 4 SV = 1 − [E5ZIC4_CAMJU] A0A059GHF9 Protease OS = Campylobacter 48.0 3.85 23 1 1 jejuni 10186 GN = N194_01570 PE = 4 SV = 1 − [A0A059GHF9_CAMJU] A0A059HXA8 50S ribosomal protein L2 26.5 7.05 15 1 1 0.841 0.997 0.884 1.031 (Fragment) OS = Campylobacter jejuni K5 GN = N218_11745 PE = 4 SV = 1 − [A0A059HXA8_CAMJU] A0A023WM76 Homoserine O- 34.2 5.12 11 1 1 1.023 0.983 1.241 0.880 succinyltransferase OS = Campylobacter jejuni subsp.", "jejuni CG8421 GN = CJ8421_08685 PE = 4 SV = 1 − [A0A023WM76_CAMJU] E5ZF74 Uncharacterized protein 14.5 12.10 14 1 1 1.093 0.936 1.113 0.998 (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_1726 PE = 4 SV = 1 − [E5ZF74_CAMJU] H7YSG7 Quinone-reactive Ni/Fe- 31.9 6.19 25 1 1 0.635 1.131 0.790 0.989 hydrogenase, small subunit (Fragment) OS = Campylobacter jejuni subsp.", "jejuni LMG 23357 GN = cje133_06525 PE = 4 SV = 1 − [H7YSG7_CAMJU] H7YGU5 L-lactate permease 56.2 3.80 22 1 1 0.494 1.037 0.781 0.713 (Fragment) OS = Campylobacter jejuni subsp.", "jejuni LMG 9879 GN = cje120_05071 PE = 4 SV = 1 − [H7YGU5_CAMJU] A0A059GH71 Uncharacterized protein 25.9 7.79 13 1 1 0.977 1.155 1.268 0.967 OS = Campylobacter jejuni 30286 GN = N196_08385 PE = 4 SV = 1 − [A0A059GH71_CAMJU] E5ZBY8 Plasminogen-binding protein 29.3 7.25 31 1 1 1.100 0.994 1.094 1.086 PgbB domain protein (Fragment) OS = Campylobacter jejuni subsp.", "jejuni 305 GN = CSS_0530 PE = 4 SV = 1 − [E5ZBY8_CAMJU] U4NW65 Flagellin OS = Campylobacter 59.0 21.85 350 0 10 jejuni 4031 GN = BN867_13230 PE = 4 SV = 1 − [U4NW65_CAMJU] The results in Table 1 show significant changes in protein expression for 34 proteins when Campylobacter jejuni NCTC11168 wildtype or the Campylobacter jejuni 11168 T268G mutant are treated with FeQ (see ratios of WT+FeQ/WT and MOMP-T+FeQ/MOMP-T).", "The impact of mutating the MOMP protein of Campylobacter jejuni at Thr-268 to glycine is also demonstrated by the ratio of Campylobacter jejuni 11168 wildtype to Campylobacter jejuni 11168 T268G mutant (WT/MOMP-T in Table 1), and showed an up-regulation with a ratio higher than 1.5 for nine proteins (Putative periplasmic cytochrome C, Aspartate ammonia-lyase, Multifunctional aminopeptidase, Succinyl-CoA ligase, DNA-binding response regulator, Flagellin subunit protein FlaB, Aspartate ammonia-lyase, Fibronectin type III domain protein and Glucosamine-fructose-6-phosphate aminotransferase) while ten proteins showed down-regulation with a ratio of less than 0.6 (Nickel-dependent hydrogenase, Putative amino-acid transporter, Chemotaxis protein (Fragment), Putative ATP/GTP binding protein, Lipoprotein, Bipartate energy taxis response protein cetB, Major outer membrane protein, Membrane protein, Flagellin A, Membrane protein and L-lactate permease).", "These results at least demonstrate that glycosylation of Campylobacter jejuni 11168 wildtype affects the expression of MOMP and Flagellin A/B, which are involved in bacterial motility, adhesion to BgAgs, aggregation and biofilm formation.", "Comparison of the ratios of WT+FeQ/WT in Table 1 shows that five proteins (Putative GMC oxidoreductase, Chemotaxis protein (Fragment), Putative amino-acid transporter, Bipartate energy taxis response protein cetB and Ferritin) were all up-regulated above 20% and ten proteins ((Formate dehydrogenase, Periplasmic nitrate reductase, Putative periplasmic cytochrome C, Succinyl-CoA ligase, Aspartate ammonia-lyase, Multifunctional aminopeptidase A, Thiamine biosynthesis protein ThiC, DNA-binding response regulator, Aspartate ammonia-lyase (different subunit) and Flagellin B, FlaB) were down-regulated more than 20%.", "Notably, the results demonstrate that the glycosylated MOMP of the wildtype strain was down-regulated about 20%, and Flagellin B (major subunit of flagellum) was down-regulated about 45% when Campylobacter jejuni 11168 wildtype was treated with FeQ.", "These results at least demonstrate that FeQ has an impact on the expression of two essential proteins involved in colonization, adhesion and motility.", "Example 16.Glycosylated Campylobacter Dominates Colonization of Chicken in a Mixed Glycosylated and Non-Glycosylated Population of Campylobacter Materials and Methods Chickens were colonized by a mixed strain (105 cfu, 50/50) of Campylobacter jejuni 11168 wildtype (O-glycosylated) and the MOMPT268G mutant of Campylobacter (non-glycosylated).", "The chickens were orally challenged and after 7 days post-infection caecal samples were analyzed.", "Results FIG.", "16 is a graph showing the colonization of chickens by a mixed strain (105 cfu, 50/50) of Campylobacter jejuni 11168 wildtype (0-glycosylated) and the MOMPT268G mutant of Campylobacter (non-glycosylated).", "The chickens were orally challenged and after 7 days post-infection caecal samples were analyzed.", "The results show that the O-glycosylated wildtype strain dominates, and is able to establish an infection.", "In contrast, the non-glycosylated strain (MOMPT268G) was unable to colonize the chicken's GI tract, and no mutant strain could be detected.", "Example 17.FeQ Prevents Formation of Biofilm on Human Teeth Materials and Methods Molar teeth were extracted from human patients, and mouth swabs taken from each patient to obtain samples of each patient's bacterial flora present in the mouth.", "The mouth swabs were cultured in the laboratory using LB media in order to grow bacterial populations ordinarily present in the mouth of each patient.", "The extracted teeth were washed and brushed extensively using PBS buffer and ethanol.", "Each patient's tooth was then placed in the bacterial culture prepared from that patient's bacterial flora sample, and cultured aerobically for 24 hours in LB media.", "The teeth were then stained with CEPLAC™ (Manx Healthcare Ltd, Warwick, UK), and washed three times with PBS-Tween (50 mL) to determine if biofilm had been formed on the teeth.", "Results All teeth stained red indicating the presence of biofilm on the teeth after just 24 hours.", "The same teeth were then cleaned using PBS buffer and ethanol, and the procedure repeated except with 48 hours of culturing in the presence of FeQ (340 μM).", "After 48 hours, no teeth stained red demonstrating that biofilms could not be established on the teeth in the presence of FeQ.", "Example 18.Efficacy of FeQ and FeTyr to Reduce Campylobacter Carriage in Chickens and Promote Growth in Chickens Materials and Methods A study was performed to evaluate growth promotion and reduction of Campylobacter carriage using FeQ and FeTyr in Ross 308 male broilers with 7 treatment groups.", "Each treatment group comprised four replicates of 10 birds per pen (40 birds/treatment group and 4 pens of 10 birds/treatment group), and there were 2 control groups and 5 test groups.", "All the test groups and one of the control groups were exposed at day 20 of the trial to dirty litter, which tested positive for Campylobacter.", "This method was used to provide a more natural method to Campylobacter challenge the birds.", "Thus there was a positive control where one treatment group was challenged with Campylobacter and one negative control group where the birds were not challenged, and five treatment groups that were all challenged with Campylobacter.", "The total number of birds used in the 7 treatment groups was 280.Details of the treatments are provided in Table 2.Treatment group 1 was a negative control where birds just received the commercial feed, and were not challenged with dirty litter containing Campylobacter.", "Treatment group 2 was the positive control where the birds received the commercial feed, and were challenged with dirty litter containing Campylobacter at day 20.Treatment group 3 received 0.22 g/L of FeQ in their drinking water and 0.22 g/Kg FeQ in their feed during the entire trial, and was challenged with dirty litter containing Campylobacter at day 20.Treatment group 5 received 0.22 g/L of FeQ in their drinking water during the entire trial, and was challenged with dirty litter containing Campylobacter at day 20.Treatment group 6 received 0.22 g/kg FeQ in their feed during the entire trial, and was challenged with dirty litter containing Campylobacter at day 20.Treatment group 7 received 0.022 g/L FeQ in their drinking water during the entire trial, and was challenged with dirty litter containing Campylobacter at day 20.Treatment group 8 received 0.02 g/L FeTyr in their drinking water during the entire trial, and was challenged with dirty litter containing Campylobacter at day 20.The FeTyr was pre-dissolved in DMSO, and diluted to provide a solution of 0.02 g/L of FeTyr in water.", "(An additional treatment group 4 was terminated due to solubility issues.)", "TABLE 2 Treatment Details Campylobacter Treatment Description Challenge 1 Control-1 Commercial feed No 2 Control-2 Commercial feed Yes 3 0.22 g/L FeQ in water + 0.22 g/kg FeQ in Yes feed 5 0.22 g/L FeQ in water Yes 6 0.22 g/kg FeQ in feed Yes 7 0.022 g/L FeQ in water Yes 8 0.02 g/L FeTyr in water Yes The birds were fed with a commercial three-phase feeding program using starter, grower and finisher feeds with formulations shown in Table 3.All diets had coccidiostat (MAXIBAN® at 0.0625% in starter and finisher phase diets and MONTEBAN® at 0.06% in finisher phase).", "Xylanase (RONOZYME® WX at 200 g per ton) and phytase (RONOZYME® P at 150 grams per ton) were added to all diets.", "TABLE 3 Basal feed formulation for starter, grower and finisher diets Raw Material STARTER % GROWER % FINISHER % Barley 10.5 8.4 7.2 Wheat 50.0 55.0 60.0 Soya Ext Hipro 26.0 23.0 19.0 Full fat Soya Cherwell 5.0 5.0 5.0 L Lysine HCl 0.40 0.30 0.30 DL-methionine 0.40 0.35 0.30 L-threonine 0.15 0.15 0.15 Soya Oil 4.0 4.50 4.75 Limestone 1.25 1.25 1.25 MonoCal phosphate 1.50 1.25 1.25 Salt 0.25 0.25 0.25 Sodium bicarbarbonate 0.15 0.15 0.15 Broiler Premix 0.40 0.40 0.40 Nutrient Analysis Analysis Analysis Fat (ether extract) 6.34 6.85 7.11 Protein 21.85 20.64 19.14 Fibre 3.08 3.02 2.97 Ash 6.01 5.68 5.50 ME-P 12.78 13.04 13.22 Total lysine 1.45 1.28 1.17 Available lysine 1.35 1.19 1.09 Methionine 0.69 0.62 0.55 Total methionine and 1.03 0.95 0.85 cysteine Threonine 0.91 0.86 0.79 Tryptophan 0.25 0.23 0.21 Calcium 0.95 0.91 0.89 Phosphorus 0.72 0.66 0.65 Available phosphorus 0.48 0.42 0.42 Salt 0.30 0.30 0.30 Sodium 0.17 0.17 0.17 Vit A 13.20 13.5 13.50 Vit D3 5.0 5.0 5.00 Vit E 100 100 100 The feeding program is show in Table 4.The birds were reared in floor pens to day 42, and fed starter, grower and finisher feed at day 0 to 11, 11 to 24, and 24 to 42 days, respectively.", "All birds were weighed individually and feed weigh backs recorded per pen at day 0, 11, 21, 24 and 42 days.", "TABLE 4 Feeding Program Feeding Phase Starter Grower Finisher (days of age) 0-11 11-24 24-42 Prior to challenging the chickens with dirty litter containing Campylobacter at day 20, each pen was tested for Campylobacter using cloacal swabs.", "All pens tested negative for Campylobacter prior to the challenge.", "At day 20, litter, which was naturally Campylobacter-contaminated was tested to confirm the presence of Campylobacter, and then added (approximately 2 kg/pen) to the litter in all pens except in pens for treatment group 1 (the negative control).", "At day 28, the pen litter was sampled to confirm the presence or absence of Campylobacter.", "At day 41 and 42, caecal samples were taken from 3 birds per pen (12 birds per treatment group) and tested for Campylobacter enumeration.", "At day 42, digesta, fecal samples, and caecal content was taken from all birds, and pooled per pen.", "Two birds per pen were also taken from treatment groups 1-3, euthanized, and blood samples taken.", "Samples were analyzed for blood chemistry, including analysis for alkaline phosphatase, aspartate amino transferase, alanine amino transferase, gamma-glutamyl transferase, lactate dehydrogenase, total protein, albumin, globulin, amylase and glucose.", "In order to minimize risk of cross-contamination, standard industry biosecurity measures were used including: disinfecting boots, changing overshoes and gloves between pens/treatments, entering Campylobacter negative pens before entering Campylobacter positive pens, and leaving adjacent pens empty.", "Daily health, culls, and mortality were recorded.", "All bird weights were recorded at 0, 11, 21, 24, 33 and 42 days.", "Weight gains, feed intake and feed conversion ratio (FCR) were derived for each feeding period.", "The effect of the treatment groups compared to the negative control group (treatment group 1) and the positive control group (treatment group 2) is shown in Tables 5-12 for the periods 0-11 days, 11-20 days, 20-25 days, 11-25 days, 25-42 days, 20-42 days, 0-20 days, and 0-42 days.", "Results FIG.", "17 shows the average body weight at day 42 for all treatment groups, and a comparison to a commercial control labeled “Target”.", "The figure shows that treatment group 1 (the negative control labeled “CNC”) attained an average body weight (ABW) of 3.437 kg at day 42 (which was higher than the commercial target of 2.979 kg).", "The positive control (labeled “CC”), which was challenged with dirty litter containing Campylobacter at day 20, in contrast only attained an ABW of 3.186 kg at day 42, which was significantly less than the negative control (treatment group 1).", "This result demonstrates that challenging with dirty litter contaminated with Campylobacter resulted in a reduction of growth of the chicken by an average of 251 grams.", "However, when the chickens were challenged with dirty litter containing Campylobacter but treated with FeQ or FeTyr in treatment groups 3, 5, 6, 7 and 8, all treatment groups performed better than the positive control demonstrating that FeQ and FeTyr treatment had a positive effect on growth.", "In fact, FeQ in feed at 0.22 g/kg (treatment group 6) produced chicken with an ABW of 3.464 kg, which was higher than the negative control ABW of 3.437 kg even though treatment group 6 had been challenged with dirty litter containing Campylobacter.", "FIG.", "18 shows the mortality adjusted feed conversion rate (MFCR) at day 42 for all treatment groups, and a comparison to a commercial control labeled “Target”.", "(A lower MFCR number is a better result.)", "The figure shows that treatment group 1 (the negative control labeled “CNC”) had a MFCR of 1.563, which was lower than the commercial target of 1.703.The positive control, labeled “CC” which was challenged with the dirty litter containing Campylobacter at day 20 had a significantly higher MFCR of 1.679 than the negative control.", "Thus challenging with dirty litter infected with Campylobacter resulted in a higher MFCR.", "However, when the chickens were challenged with dirty litter infected with Campylobacter but treated with FeQ or FeTyr in treatment groups 3, 5, 6, 7 and 8, all treatment groups performed better than the positive control demonstrating that FeQ and FeTyr treatment had a positive effect on MFCR (i.e.", "decreasing the numerical MFCR).", "The results show that treatment groups 3, 5, 6, 7 and 8 had MFCR values of 1.595, 1.560, 1.563, 1.612 and 1.577, respectively.", "Furthermore, treatment groups 5 and 6 performed as well as the negative control even when challenged with dirty litter containing Campylobacter.", "FIG.", "19 shows the number of Campylobacter colony forming units per gram (cfu/g) of bird droppings at day 42 for treatment groups 1-3 and 6-8.", "(A lower number is a better result.)", "The results show that treatment groups 3 and 6-8 all performed better than the positive control (treatment group 2) demonstrating that FeQ and FeTyr had a positive effect on reducing Campylobacter infection of poultry.", "Notably, chicken treated with FeTyr, FeQ in feed, and FeQ in feed and water all had colony forming units of Campylobacter per gram of dropping that were similar to, or less than, those of the negative control group (treatment group 1).", "The detection of low levels of Campylobacter in the negative controls demonstrates how highly contagious the bacterium is, and is likely to be an indication that a small number of birds in the negative control group became infected despite not being experimentally challenged with dirty litter.", "The results in FIG.", "19 for the low concentration of FeQ in water (0.022 g/L; treatment group 7) appears to show less of an effect than the other treatment groups, although this difference was considered more likely due to experimental error for example following cross contamination of samples.", "As discussed below, the results obtained from a further experiment, as given in FIG.", "20 confirm that treatment group 7 did, indeed, also provide the highly beneficial effect.", "FIG.", "20 shows the average number of Campylobacter colony forming units per gram (cfu/g) of caeca samples at day 42 for treatment groups 1-3 and 5-8.The results show that all the treatment groups (3 and 5-8) all performed better than the positive control (treatment group 2) demonstrating that FeQ and FeTyr had a positive effect on reducing Campylobacter infection of poultry.", "The effect of the treatments on overall livability and European production and efficiency factor (EPEF) is shown in Table 5.", "(EPEF=[(Livability×Live weight in kg at end of trial/Age in Days×FCR commercial)×100].", "The effect of FeQ treatment on growth performance in the absence of Campylobacter challenge during the starter phase (0-11 days) and period from 0-20 days is shown in Table 14.Since the negative and positive controls (treatment groups 1 and 2) are identical prior to challenge with the dirty litter at day 20, these groups may be pooled for comparison to treatment groups 3, 5, 6, and 7 in order to see if FeQ had an effect on growth in the absence of a challenge by dirty litter contaminated with Campylobacter during the first 20 days of growth.", "The results demonstrate that FeQ promotes growth of chicken even in the absence of a challenge from dirty litter contaminated with Campylobacter.", "At day 20, the average body weight (ABW) for the control groups (treatment groups 1 and 2) is 0.927 kg versus 0.963 kg for treatment groups 3, 5, 6 and 7 which all received FeQ.", "This improvement in body weight is also reflected in a significantly better MFCR for the FeQ treated birds.", "Table 11 shows the MFCR for the birds treated in groups 3, 5, 6 and 7 is 1.2996 versus 1.3374 for the control groups (treatment groups 1 and 2).", "Notably the P-value is less than 0.05.The same positive effect of FeTyr treatment on growth performance in the absence of Campylobacter challenge is also evident from Table 11.The AWG during the first 20 days of production for chicken treated with FeTyr (treatment group 8) is 0.895 kg compared to 0.884 and 0.889 kg for treatment groups 1 and 2 (negative and positive controls).", "Furthermore, the MFCR during the first 20 days of production for chicken treated with FeTyr (treatment group 8) is 1.311 versus 1.32 and 1.355 for treatment groups 1 and 2, respectively.", "(A lower MFCR value is an improvement.)", "The results of this study demonstrate that both FeQ and FeTyr promote growth and decrease the mortality adjusted feed conversion ratio (MFCR) in the absence or presence of dirty litter contaminated with Campylobacter.", "TABLE 5 Effect of treatments on growth performance during starter phase (day 0-11) ABW AFD AWG MFCR Treatment Day 0 Day 11 Day 0-11 1 0.040 0.331 0.348 0.291 1.239b 2 0.040 0.337 0.359 0.297 1.228b 3 0.040 0.346 0.356 0.306 1.181ab 5 0.040 0.334 0.352 0.294 1.210ab 6 0.041 0.351 0.360 0.310 1.168a 7 0.040 0.325 0.348 0.285 1.236b 8 0.040 0.329 0.353 0.289 1.229b P-value 0.136 0.418 0.979 0.463 0.005 SED 0.000 0.013 0.016 0.013 0.018 P-value for contrast 1 vs 2 0.512 0.667 0.519 0.682 0.584 1 vs 2 to 8 0.666 0.573 0.603 0.583 0.045 2 vs 3567 0.632 0.844 0.723 0.834 0.054 5 vs 6 0.099 0.213 0.627 0.233 0.033 5 vs 7 0.141 0.466 0.804 0.494 0.170 2 vs 8 0.645 0.538 0.709 0.549 0.982 a-bwithin a column reflects differences between treatments when P < 0.05; SED = Standard errors of difference of means; ABW = average body weight (kg); AFD = average feed intake (kg); AWG = average weight gain (kg); MFCR = Mortality adjusted feed conversion ratio; FCR = Feed conversion ratio-commercial.", "TABLE 6 Effect of treatments on growth performance during grower phase (day 11-20) ABW AFD AWG MFCR Treatment Day 20 Day 11-20 1 0.924 0.799 0.593 1.362 2 0.929 0.838 0.592 1.421 3 0.972 0.857 0.625 1.375 5 0.943 0.821 0.609 1.348 6 0.991 0.841 0.640 1.343 7 0.947 0.829 0.622 1.333 8 0.935 0.809 0.606 1.351 P-value 0.358 0.311 0.279 0.279 SED 0.032 0.025 0.021 0.036 P-value for contrast 1 vs 2 0.875 0.133 0.977 0.115 1 vs 2 to 8 0.248 0.094 0.175 0.987 2 vs 3567 0.189 0.961 0.075 0.020 5 vs 6 0.145 0.427 0.160 0.884 5 vs 7 0.913 0.737 0.546 0.673 2 vs 8 0.850 0.253 0.516 0.065 SED = Standard errors of difference of means; ABW = average body weight (kg); AFD = average feed intake (kg); AWG = average weight gain (kg); MFCR = Mortality adjusted FCR; FCR = FCR commercial.", "TABLE 7 Effect of treatments on growth performance during period day 20-25.ABW AFD AWG MFCR Treatment Day 25 Day 20-25 1 1.366 0.662 0.442 1.500 2 1.371 0.652 0.442 1.550 3 1.424 0.667 0.453 1.477 5 1.384 0.658 0.441 1.495 6 1.426 0.685 0.434 1.599 7 1.388 0.661 0.441 1.513 8 1.377 0.662 0.442 1.499 P-value 0.723 0.916 0.999 0.882 SED 0.044 0.026 0.030 0.096 P-value for contrast 1 vs 2 0.912 0.685 0.998 0.604 1 vs 2 to 8 0.403 0.932 0.996 0.759 2 vs 3567 0.339 0.444 0.990 0.707 5 vs 6 0.361 0.311 0.826 0.294 5 vs 7 0.930 0.902 0.988 0.854 2 vs 8 0.892 0.693 0.999 0.604 SED = Standard errors of difference of means; ABW = average body weight (kg); AFD = average feed intake (kg); AWG = average weight gain (kg); MFCR = Mortality adjusted FCR; FCR = FCR commercial.", "TABLE 8 Effect of treatments on overall growth performance during grower phase (day 11-25) AFD AWG MFCR Treatment Day 11-25 1 1.462 1.035 1.421 2 1.490 1.034 1.457 3 1.524 1.078 1.417 5 1.479 1.050 1.409 6 1.526 1.075 1.440 7 1.490 1.064 1.406 8 1.471 1.048 1.414 P-value 0.660 0.804 0.598 SED 0.042 0.036 0.030 P-value for contrast 1 vs 2 0.516 0.984 0.241 1 vs 2 to 8 0.293 0.406 0.891 2 vs 3567 0.657 0.267 0.118 5 vs 6 0.280 0.498 0.300 5 vs 7 0.787 0.707 0.925 2 vs 8 0.664 0.695 0.165 SED = Standard errors of difference of means; ABW = average body weight (kg); AFD = average feed intake (kg); AWG = average weight gain (kg); MFCR = Mortality adjusted FCR.", "TABLE 9 Effect of treatments on overall growth performance during finisher phase (day 25-42) ABW AFD AWG MFCR Treatment Day 42 Day 25-42 1 3.437 3.479 2.070b 1.688 2 3.186 3.480 1.814a 1.889 3 3.342 3.387 1.918ab 1.773 5 3.407 3.357 2.023b 1.706 6 3.464 3.315 2.039b 1.704 7 3.304 3.362 1.916ab 1.793 8 3.341 3.434 1.964ab 1.716 P-value 0.027 0.56 0.009 0.211 SED 0.075 0.099 0.062 0.081 P-value for contrast 1 vs 2 0.004 0.997 <.001 0.022 1 vs 2 to 8 0.110 0.247 0.016 0.233 2 vs 3567 0.004 0.129 0.004 0.035 5 vs 6 0.455 0.680 0.800 0.988 5 vs 7 0.187 0.960 0.101 0.294 2 vs 8 0.053 0.649 0.027 0.046 a-bwithin a column reflects differences between treatments when P < 0.05; SED = Standard errors of difference of means; ABW = average body weight (kg); AFD = average feed intake (kg); AWG = average weight gain (kg); MFCR = Mortality adjusted FCR; FCR = FCR commercial.", "TABLE 10 Effect of treatments on the growth performance during the experimental period of day 20-42 (after the birds were challenged) AFD AWG MFCR Treatment Day 20-42 1 4.142 2.512b 1.653 2 4.131 2.256a 1.820 3 4.054 2.370ab 1.713 5 4.015 2.464ab 1.665 6 4.001 2.473ab 1.678 7 4.023 2.357ab 1.739 8 4.096 2.406ab 1.676 P-value 0.767 0.025 0.344 SED 0.110 0.068 0.075 P-value for contrast 1 vs 2 0.926 0.001 0.038 1 vs 2 to 8 0.306 0.028 0.290 2 vs 3567 0.229 0.008 0.055 5 vs 6 0.898 0.894 0.856 5 vs 7 0.941 0.138 0.331 2 vs 8 0.752 0.042 0.070 a-bwithin a column reflects differences between treatments when P < 0.05; SED = Standard errors of difference of means; ABW = average body weight (kg); AFD = average feed intake (kg); AWG = average weight gain (kg); MFCR = Mortality adjusted.", "TABLE 11 Overall effect of treatments on growth performance during the experimental period of day 0-20 (before birds were challenged).", "AFD AWG MFCR Treatment Day 0-20 1 1.147 0.884 1.320 2 1.196 0.889 1.355 3 1.213 0.931 1.310 5 1.173 0.903 1.303 6 1.201 0.951 1.284 7 1.178 0.907 1.302 8 1.161 0.895 1.311 P-value 0.623 0.368 0.225 SED 0.038 0.032 0.025 P-value for contrast 1 vs 2 0.215 0.881 0.181 1 vs 2 to 8 0.191 0.251 0.627 2 vs 3567 0.860 0.188 0.012 5 vs 6 0.476 0.150 0.469 5 vs 7 0.907 0.899 0.978 2 vs 8 0.371 0.846 0.094 SED = Standard errors of difference of means; ABW = average body weight (kg); AFD = average feed intake (kg); AWG = average weight gain (kg); MFCR = Mortality adjusted.", "TABLE 12 Overall effect of treatment groups on growth performance (day 0-42) AFD AWG MFCR Treatment Day 0-42 1 5.289 3.397b 1.563 2 5.328 3.145a 1.679 3 5.267 3.302ab 1.595 5 5.188 3.367ab 1.560 6 5.201 3.423b 1.563 7 5.201 3.265ab 1.612 8 5.258 3.301ab 1.577 P-value 0.920 0.028 0.193 SED 0.132 0.075 0.047 P-value for contrast 1 vs 2 0.773 0.004 0.024 1 vs 2 to 8 0.633 0.111 0.352 2 vs 3567 0.29 0.004 0.018 5 vs 6 0.920 0.461 0.954 5 vs 7 0.924 0.190 0.284 2 vs 8 0.601 0.053 0.043 a-bwithin a column reflects differences between treatments when P < 0.05; SED = Standard errors of difference of means; ABW = average body weight (kg); AFD = average feed intake (kg); AWG = average weight gain (kg); MFCR = Mortality adjusted.", "TABLE 13 The effect of treatments on overall liveability and European production and efficiency factor (EPEF) EPEF Treatment Day 20 Day 42 1 318.3 282.8 2 334.7 250.7 3 350.4 262.9 5 352.0 278.3 6 364.8 265.0 7 354.5 276.2 8 336.4 296.0 P-value 0.547 0.842 SED 23.83 31.68 P-value for contrast 1 vs 2 0.500 0.323 1 vs 2 to 8 0.111 0.645 2 vs 3567 0.285 0.437 5 vs 6 0.599 0.680 5 vs 7 0.919 0.949 2 vs 8 0.945 0.170 TABLE 14 Effect of treatments on growth performance in absence of Campylobacter challenge during starter phase (0-11 days) and period 0-20 days.", "ABW ABW AFD 0-20 AWG 0-20 MFCR Treatment Day 11 Day 20 days days 0-20 Groups 1 & 2 0.334 0.927 1.172 0.887 1.3374 FeQ 0.339 0.963 1.191 0.923 1.2996 (Groups 3, 5, 6, 7) P-value 0.584 0.079 0.432 0.078 0.029 SED 0.009 0.020 0.024 0.020 0.016 ABW = average body weight (kg); AFD = average feed intake (kg); AWG = average weight gain (kg); MFCR = mortality adjusted feed conversion ratio Example 19.FeDOPA Treatment Makes Antibiotic Resistant Strain of Enteropathogenic E. Coli (EPEC) E2348/69 Lose Resistance to Antibiotic Materials and Methods The impact on the growth curve of antibiotic resistant Enteropathogenic E. coli (EPEC) strain E2348/69 (genotype Wild Type EPEC O17:H6) when grown in the presence of a fixed concentration of gentamicin (1.25 μM) and an increasing concentration of FeDOPA versus the strain grown in the presence of only FeDOPA or only gentamicin, was determined.", "Results FIGS.", "21A-C are graphs that show the impact on the growth curve of antibiotic resistant Enteropathogenic E. coli (EPEC) strain E2348/69 (genotype Wild Type EPEC O17:H6) when grown in the presence of a fixed concentration of gentamicin (1.25 μM) and an increasing concentration of FeDOPA (FIG.", "21A: 130 μM, FIG.", "21B: 160 μM and FIG.", "11C: 200 μM) versus the strain grown in the presence of only FeDOPA or only gentamicin.", "The graphs show that the rate of growth of the strain was inhibited in the presence of gentamicin and FeDOPA relative to the rate of growth of the strain just in the presence of gentamicin.", "This is evidence that FeDOPA can be used in conjunction with antibiotics to kill or inhibit the growth of antibiotic resistant bacteria.", "Example 20.FeDOPA Prevents Attachment of Bacteria to Surfaces Materials and Methods Enteropathogenic E. coli (EPEC) E2348/69 were grown in wells for 48 hours at 37° C. in the presence of FeDOPA (10-250 μM), and in the absence of FeDOPA (as control).", "After 48 hours, the wells were washed in order to remove suspended cells.", "Crystal violet was then added to each well.", "The wells were then washed to remove excess dye.", "A mixture of acetone/ethanol was then added to the wells to re-suspend any cells attached to the plastic surface of the wells, and dissolve any dye present.", "The presence of dye in each well was then quantified by measuring the O.D.", "at 570 nm.", "Results In the absence of FeDOPA, EPEC binds to the plastic surface and forms a biofilm that is readily detected by dying with crystal violet.", "However, in the presence of FeDOPA, EPEC attachment to the plastic surface and formation of a biofilm is inhibited.", "FIG.", "22 shows quantitatively the difference in the attachment of EPEC cells to the plastic well surface in the absence and presence of FeDOPA by measurement of the optical absorbance of crystal violet that was absorbed by EPEC cells attached to the surface.", "At an FeDOPA concentration of 68-250 μM attachment of bacterial cells to the surface and biofilm formation is inhibited.", "Example 21.Campylobacter jejuni Loses Motility after Treatment with FeQ Campylobacter jejuni NCTC 11168 was treated with FeQ (34 μM) and a plate containing brain-heart infusion (BHI) medium inoculated with 5 2×105 colony forming units of the treated bacteria and the plate was cultured for 43 hours.", "The growth and motility of the bacteria after treatment with FeQ was compared to a positive control where the bacteria had not been treated with FeQ, and also to a negative control where no bacteria were applied to a plate of the BHI medium.", "The data (not shown) showed that after 43 hours, the Campylobacter jejuni treated with FeQ had a clear zone around the bacteria indicating that the bacteria was not motile.", "In contrast, Campylobacter jejuni that was not treated with FeQ was motile, and spread around the culture plate.", "There was no growth visible, as expected, on the plates that were not inoculated with bacteria.", "The experiment demonstrates that the Campylobacter jejuni loses motility after treatment with FeQ, and is consistent with the results obtained by iTRAQ analysis that demonstrate that FeQ down regulates FlaA expression (the Flagella of Campylobacter).", "Example 22.Disruption of a Preformed Biofilm with FeTyr Crystal violet assays were used as described above to demonstrate that FeTyr could disrupt a pre-formed biofilm.", "A mature biofilm formed by EPEC-pgA++ was treated with FeTyr for 24, 48 and 72 hours at FeTyr concentrations of 100 μM, 150 μM and 200 μM and the presence of the biofilm after these times was compared to an untreated biofilm (labeled “Control”) using a crystal violet assay.", "The color of the control wells was more intense in color at 72 hours than those that were treated with FeTyr at 100, 150 and 200 μM for 72 hours.", "FIG.", "23 shows quantitatively the optical absorbance of crystal violet at 570 nm that was absorbed by the EPEC cells that remained attached to the surface of the plastic well after a mature biofilm formed by EPEC-pgA++ was treated with FeTyr (shown as FeY in FIG.", "23) at 100 μM, 150 μM and 200 μM compared to an untreated biofilm (labeled “Control”) in the crystal violet assay.", "A significantly lower optical absorbance was found at 72 hours for the biofilm treated with FeTyr at 100, 150 and 200 μM at 72 hours.", "These results demonstrate that FeTyr can disrupt a pre-formed biofilm.", "Example 23.Disruption of a Preformed Biofilm with FeTyr and Fe-DOPA A BioFlux system was used to demonstrate that FeTyr and Fe-DOPA can be used to disrupt a mature EPEC-ΔcsrA biofilm.", "Our studies showed that that a mature biofilm of EPEC-ΔcsrA can be formed in the presence of LB medium 30% v/v and imaged (data not shown).", "The mature biofilm was treated with FeTyr at concentrations of 100, 150 and 200 μM for 20 hours and compared to a control biofilm that had just been treated with LB medium 30% v/v.", "It was found that biofilm dispersion increased as the concentration of FeTyr was increased from 100 to 200 μM (data not shown).", "Mature biofilm was treated with FeDOPA at a concentration of 100 μM for 20 hours and compared to a control biofilm that had just been treated with LB medium 30% v/v.", "It was found that Fe-DOPA dispersed the biofilm at a concentration of 100 μM (data not shown).", "Example 24.Treatment of an Acne Patient with FeQ An 18 year old female patient was treated continuously for 30 days by applying a solution of ferric quinate (340 μM) to her acne vulgarism (“acne”) once each day.", "Within 5 days of the start of treatment, her acne, which had not previously responded to treatment with antibiotics, began to show signs of healing.", "After treatment for 30 days, her acne was completely healed.", "Her acne did not recur even after discontinuation of treatment for over one year.", "Example 25.Effect of FeQ on Biofilm Formation of a Medical Device Materials and Methods To investigate the effect of Ferric Quinate (FeQ) on the surface integrity of contact lenses, two contact lenses were independently incubated in either saline solution, or saline solution with a final concentration of 340 μM FeQ at 4° C. for 7 days, whilst gently shaking.", "The lenses were then washed 6 times with phosphate-buffered solution (PBS)+0.05% Tween.", "Each lens was then washed twice with distilled water before analysis via environmental scanning electron microscope (ESEM).", "To investigate biofilm formation on the contact lens, clinically determined PAO-1 strains of Pseudomonas aeruginosa were incubated with the lenses in either Luria-Bertani Media (LB) or LB with a final concentration of 340 μM FeQ at 37° C. for 24 hours in a non-shaking incubator.", "The lenses were then washed 6 times with PBS+0.05% Tween, before being stored overnight in PBS+0.05% Tween.", "In preparation for the ESEM, formaldehyde was added to a final concentration of 1% and incubated for 10 minutes in order to inactivate the bacteria.", "The lenses were then washed 4 times with PBS+0.05% Tween, and immediately before analysis the lenses were washed a further two times with distilled water.", "Results Surface Integrity Lenses were treated with 340 μM FeQ or left untreated (control) to investigate the effect, if any, of FeQ treatment on the surface integrity of the contact lens.", "The results show that FeQ at 340 μM does not have any visible significant effect (via ESEM) on the surface integrity of the contact lens.", "Biofilm Formation ESEM images (data not shown) following incubation with bacteria only showed large scale biofilm development of Pseudomonas aeruginosa, over the surface of the contact lens.", "Analysis via the ESEM requires vacuum and causes areas of the biofilm to dehydrate, which is responsible for the perforated appearance of the biofilm of the contact lens.", "The dehydration gives perception of depth, and shows the biofilm formed in the absence of FeQ to be substantial.", "Individual bacteria were visible in the biofilm, surrounded by the extracellular matrix (ECM).", "The impact of incubation with bacteria in the presence of FeQ 340 μM was also investigated.", "These images (data not shown) showed that, in the presence of FeQ at 340 μM, Pseudomonas aeruginosa appears as either single bacterium, or small aggregates of bacteria, with no apparent ECM formation.", "These results indicate that FeQ inhibits biofilm formation of Pseudomonas aeruginosa.", "Based on these results, it can be concluded the FeQ and other compounds as described herein can be used to inhibit or prevent biofilm formation on medical devices, such as but not limited to, contact lenses.", "Example 26: Metabolomic Analysis Materials and Methods Strains analysed were the wild type Campylobacter jejuni NCTC 11168, and a mutant (MOMP268T/G) where Thr-268 of the MOMP protein of the wild type is mutated to glycine, resulting in a strain of the bacteria in which the MOMP protein cannot be glycosylated.", "The mutant is further described in WO 2013/121214.The strains were grown for 48 hours in Mueller Hinton Broth (MHB).", "In non-control samples, the bacteria (wild type and mutant) were treated with FeQ at a concentration of 340 μM.", "Three replicates of a sample were taken from each culture, and each replicate was analysed three times (i.e.", "producing 9 reads for each sample).", "Thus, for example, the sample taken from fresh media (FM) produced nine reads, labelled FM-1_1, 1_2, 1_3, 2_1, 2_2, 2_3, 3_1, 3_2 and 3_3, respectively.", "It is the same for each of the other samples, which are: SMWT: spent media from the wild type control culture SMWTF: spent media from the wild type culture grown in the presence of FeQ SMMT: spent media from the mutant control culture SMMTF: spent media from the mutant culture grown in the presence of FeQ For metabolite profiling, LC was performed on an Accela system (Thermo Fisher Scientific, Hemel Hempstead, UK).", "Chromatographic separation was carried out using a ZIC-pHILIC (150 mm×4.6 mm, 5 μm column, Merck Sequant) as previously described (Creek et al.", "2011, Anal Chem 83, 8703-8710).", "Briefly, the column was maintained at 45° C. and samples were eluted with a linear gradient from 80% B to 5% B over 15 min, followed by an 2 min linear gradient from 5% B to 80% B, and 7 min re-equilibration with 80% B at the flow rate of 300 μl/min Mobile phase A was 20 mM ammonium carbonate in water and mobile phase B was acetonitrile 100% acetonitrile.", "The injection volume was 10 μl and samples were maintained at 4° C. An Orbitrap Exactive (Thermo Fisher Scientific, Hemel Hempstead, UK) with a HESI 2 probe was operated in polarity switching mode, with the following settings: resolution 50 000, AGC 1×106, m/z range 70-1400, sheath gas 40, auxiliary gas 5, sweep gas 1, probe temperature 150° C., and capillary temperature 275° C. For positive mode ionisation: source voltage +4.5 kV, capillary voltage +50 V, tube voltage +70 kV, skimmer voltage +20 V. For negative mode ionisation: source voltage −3.5 kV, capillary voltage −50 V, tube voltage −70 V, skimmer voltage −20 V. Mass calibration was performed for each polarity immediately before each analysis batch.", "The calibration mass range was extended to cover small metabolites by inclusion of low-mass contaminants with the standard Thermo calibration mixture masses (below m/z 1400), C2H6NO2 for positive ion electrospray ionisation (PIESI) mode (m/z 76.0393) and C3H5O3 for negative ion electrospray ionisation (NIESI) mode (m/z 89.0244).", "Data Processing and Analysis Raw LC-MS data were processed with XCMS for untargeted peak-picking (Tautenhahn et al.", "2008, BMC Bioinformatics 9, 504) and mzMatch.R for peak matching and annotation of related peaks (Scheltema et al.", "2011, Analytical Chemistry 83, 2786-2793).", "Putative metabolite identification was carried out by IDEOM using the default parameters (Creek et al.", "2012, Analytical Chemistry 84, 8442-8447).", "Metabolite identification was performed by matching accurate masses and retention times of authentic standards (Level 1 metabolite identification according to the Metabolomics Standards Initiative (Sumner et al.", "2014, Metabolomics 10, 1047-1049; Sumner et al.", "2007, Metabolomics 3, 211-221).", "However, when standards were not available, predicted retention times were used, hence these identifications should be considered as putative (Level 2 identification).", "Results and Conclusions FIG.", "24A shows the data from positive mode analysis, as an OPLS-DA scores plot.", "This shows a clear separation between fresh media (FM) and other spent media (SMWT; SMWTF; SMMT; SMMTF) which demonstrates that a lot of metabolites were excreted and consumed during cell culture.", "FIG.", "24B also shows the data from the positive mode analysis.", "The fresh media (FM) results were removed from the plot, because they are so different from the other samples so that any differences between the different spent media samples could be hidden.", "This plot shows a clear separation between wild type (SMWT) and wild type+FeQ (SMMTF), but the SMMT and SMMTF clustered more closely.", "This indicates that FeQ does not cause large detectable change between mutant and mutant+FeQ.", "Overall, it is clear that there are less metabolic changes caused by FeQ in the mutant than in the wild type.", "FIG.", "24C contrasts from FIG.", "24A in that it shows the data from the negative mode analysis, although essentially the same pattern and conclusions apply as in FIG.", "24A.", "FIG.", "24D contrasts with FIG.", "24B in that it shows the data from the negative mode analysis.", "The negative mode data in FIG.", "24D shows slightly different trends from the positive mode data, and demonstrates a clear separation between mutant (SMMT) and mutant+FeQ (SMMTF) samples, as well as between the SMWT and SMWTF samples.", "These data demonstrate how fundamentally the metabolism of bacteria is changed by treatment with FeQ.", "This is consistent with the phenotypic changes observed in bacteria treated with FeQ (as confirmed by iTRAQ results as discussed in Example 15), and provides an insight into the mechanism underlying the ability of FeQ and its related compounds as discussed in section III.A of this application to treat bacteria and cause an inhibition in their ability to form biofilm, colonise chickens and other animals, and even make the bacteria less resistance to antibiotics.", "Example 27: Preparation Protocol for K[Fe(C7H11O6)3](OH) 3H2O (FeQ) FeCl3.6H2O (50 g, 184 mmol, Alfa Aesar, 97%) was placed in a flask and dissolved in 300 mL of H2O (J.T.", "baker, HPLC grade).", "To that solution, D-(−)-quinic acid (110 g, 572 mmol, Buchlr Gmbh, 96%) was added slowly with continuous stirring.", "The pH of the solution was adjusted to ˜3 by addition of 10M KOH (Alfa Aesar, 85%) (˜80 mL was required).", "The dark yellow solution darkened to brownish upon addition of KOH.", "The dark solution was stirred for 1 h at room temperature.", "After stirring at room temperature for 1 h ethanol (EMD, 94%) (2.5 l) was added slowly to the solution with stirring.", "After addition of approximately ¼ of the total ethanol, the solution lightened visibly and a fine solid began to precipitate from solution.", "After addition of the remaining ethanol, the solution is allowed to sit overnight at room temperature.", "The solids are collected by vacuum filtration on a fritted funnel and allowed to dry on the funnel while the vacuum is continued for 2-3 h. The bright yellow solid is spread in a thin layer in a drying dish and dried open to the air for 3 days followed by drying under vacuum for 48 h to give 155 g of the final product.", "Example 28: Synthesis of Fe(Tyr)3 L-tyrosine (5.43 g, 30 mmol, Chem Impex, 99.5%) and LiOH.H2O (1.26 g, 30 mmol, EMD, 94%) were dissolved in water (250 ml, J.T.", "Baker, HPLC grade)) and the solution heated to 70° C. for 20 min.", "The FeCl3 salt (1.62 g, 10 mmol, Alfa Aesar, 98%)) was dissolved in a minimum quantity of water (3-5 ml) and was added to the tyrosine/LiOH solution.", "Precipitation (brown solid) was almost instantaneous but stirring with heating continued for 15 min.", "The product was allowed to cool to room temperature and was collected by filtration.", "The product was air dried and then further dried in a lyophilizer.", "Isolated yield was 5.85 g. Example 29: Synthesis of Fe(DOPA)3 L-Dopa (11.84 g, 60 mmol, AK Scientific, 98%) and LiOH.H2O (2.52 g, 60 mmol, EMD, 94%) were dissolved in water (100 ml, J.T.", "Baker, HPLC grade) and the solution heated to 70° C. for 20 min.", "The FeCl3 salt (3.2 g, 20 mmol, Alfa Aesar, 98%) was dissolved in a minimum quantity of water (6-10 ml) and was added to the Dopa/LiOH solution vigorous.", "Precipitation (very dark purple) was almost instantaneous but stirring with heating continued for 15 min.", "The product was allowed to cool to room temperature and was collected by filtration.", "The product was air dried and then further dried in a lyophilizer Isolated yield was 6.5 g. More solid (4 g) was collected from the filtrate and dried in the same way.", "Overall yield was 10.5 g. Example 30: Fe-Q and Fe-Phe Potentiate the Effect of Antibiotics Methods To investigate effects upon antibiotic resistance, a laboratory strain of Psuedomonas aeruginosa (PAO1N) and a mixed population of clinical isolates (PAO Mixed) were incubated in Luria-Bertani (LB) media alone, or with different concentrations (34 μM, 100 μM, 200 μM and 340 μM) of FeQ or FePhe.", "Each of the different media, bar one control, contained 10 μg/ml of the aminoglycoside antibiotic Amikacin.", "10 μl of the bacterial strains were added into each well of a 96-well micro-titer plate, before 290 μl of the relevant media was added to wells.", "Each different condition was repeated in sextuplicate.", "The plate was incubated at 37° C. within a micro-titer plate reader for 17.5 hours, with the OD600 read every 30 minutes.", "Results The results are shown in FIGS.", "25A and 25B.", "These figures show that Fe-Q and Fe-Phe provide similar effects at reducing tolerance of PAO1N and PAO Mixed to the aminoglycoside Amikacin." ] ]
Patent_15874321
[ [ "Electrode Composite Material, Preparation Method Thereof, Cathode And Battery Including The Same", "An electrode composite material is disclosed in the invention.", "The electrode composite material comprises ABxCyDz, wherein A is selected from at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer; B comprises sulfur, C is selected from carbon material; D is selected from metal oxides, 1≤x≤20, 0≤y<1, and 0≤z<1.", "Comparing to the prior art, the conductivity of the electrode composite material is obviously increased, the material is dispersed uniformly and the size of the material is small.", "The electrochemical performance of the electrode composite material is improved.", "It has a good cycle life and high discharging capacity efficiency.", "A method for manufacturing the electrode composite material, a positive electrode using the electrode composite material and a battery including the same are also disclosed in the invention." ], [ "1-10.", "(canceled) 11.A method for preparing an electrode composite material comprising the following steps: dispersing sulfur in a first solvent to get a first solution; adding at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer into a second solvent to obtain a second solution; mixing the first solution, the second solution, and at least one metal oxide by ball milling in an inert atmosphere to obtain a mixture; drying the mixture to remove the solvents from the mixture; and then heat-treating the dried mixture in a protective gas; and cooling the heat-treated mixture to obtain the electrode composite material; wherein the first solvent is selected from one of carbon disulfide, toluene, and liquid hydrocarbon, wherein the second solvent is selected from one of dimethylformamide, dimethyl acrylamide, a mixture of dimethyl acrylamide and lithium chloride, and dimethyl sulfoxide, and wherein the heat-treating step is performed at a temperature of 150-450° C. for a duration of 1-20 h. 12.The method for preparing an electrode composite material according to claim 11, wherein the metal oxide is MgaNibO, wherein 0<a<1, 0<b<1 and a+b=1.13.The method for preparing an electrode composite material according to claim 11, wherein the metal oxide comprises a mixture of MgO and NiO, or a mixture of MgO and CuO.", "14.The method for preparing an electrode composite material according to claim 11, wherein the ball milling is performed at a rotation speed of 200-1300 rpm for a duration of 0.5-12 h. 15.The method for preparing an electrode composite material according to claim 11, wherein the drying step is performed at a temperature of 35-75° C. for a duration of 3-12 h. 16.The method for preparing an electrode composite material according to claim 11, wherein the protective gas is selected from one of Ar, N2, a reductive gas mixture of Ar and H2, and a reductive gas mixture of N2 and H2.17.An electrode composite material prepared by method of claim 11, the electrode composite material comprising ABxCyDz, wherein A is selected from at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer, B is sulfur, C is a carbon based material, and D is a metal oxide; and wherein 1≤x≤20, 0≤y<1, and 0≤z<1.18.The electrode composite material according to claim 17, wherein y=0 and 0<z<1.19.The electrode composite material according to claim 17, wherein 0<y<1 and 0<z<1.20.The electrode composite material according to claim 17, wherein the polyacrylonitrile copolymer is selected from at least one of polyacrylonitrile methylmethacrylate copolymer, and polyacrylonitrile polypyrrole copolymer.", "21.The electrode composite material according to claim 17, wherein the carbon based material is selected from at least one of ketjen black, acetylene black, active carbon, single wall carbon nano-tube, multi wall carbon nano-tube, and graphene.", "22.The electrode composite material according to claim 17, wherein the metal oxide of D is selected from at least one of MgaNibO, MgO, NiO, V2O5, CuO, MgcCudO, La2O3, Zr2O3, Ce2O3, and Mn2Of, wherein 0<a<1, 0<b<1, a+b=1, 0<c<1, 0<d<1, and c+d=1, and wherein the value of f is 2 or 3 or 4 or 7.23.A cathode for a battery, comprising the electrode composite material according to claim 17.24.A battery, comprising a cathode, an anode and an electrolyte provided between the cathode and anode, the cathode comprising a cathode current collector and the electrode composite material according to claim 17.25.The battery according to claim 24, wherein the electrolyte is selected from one of polyvinylidene fluoride, polyvinylidene fluoride-poly(methyl methacrylate) copolymer, polyvinylidene fluoride-hexafluoropropylene copolymer, and polyethylene glycol boric acid ester polymers.", "26.The battery according to claim 24, wherein the cathode current collector is selected from one of aluminum foil, nickel foam, and stainless steel net." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>With the development of technology, energy especially renewable green energy is in great demand.", "Batteries as energy storage and conversion device are playing an irreplaceable role.", "Lithium-ion batteries are leading power sources due to their high weight and volume specific energy.", "The development of lithium-ion battery focuses on low cost, high energy density, long cycle life and green environmental protection.", "Currently, the commercialized cathode material is lithium Intercalation compounds with a layer structure (lithium cobalt oxide), spinel structure (lithium manganese oxide) or olivine structure.", "Lithium cobalt oxide (LiCoO 2 ) has high theoretical capacity of 275 mAh/g, along with high cost and toxicity, and its character of easy decomposition during overcharge may cause dramatically decrease of battery capacity and safety issues.", "Lithium manganese oxide (LiMn 2 O 4 ) with theoretical capacity of 148 mAh/g, actually less than 130 mAh/g, is unstable, of which the crystal structure may deform during the charging and discharging process, resulting in low cycling efficiency; lithium Iron phosphate (LiFePO 4 ) with theoretical capacity of 172 mAh/g has poor conductivity and reducing reversible capacity.", "The above conventional lithium-ion battery cathode materials cannot satisfy the requirement of battery development due to their capacity and some other problems.", "Theoretical capacity of elemental sulfur is 1675 mAh/g which is much higher than those of commercialized cathode materials.", "The battery composed of sulfur and metal lithium has theoretical specific energy of 2600 mAh/g which is the main stream in battery development.", "Cathode materials containing elemental sulfur, sulfur-containing inorganic sulfides, organic sulfides, organic disulfides, organic polysulfides, or carbon-sulfur have been wildly researched by now, but some problems still exist therein.", "Firstly, conductive agents have to be added due to the poor conductivity of sulfur and sulphide; secondly, solubility of polysulfides as discharge products in electrolyte may affect the cyclability of battery.", "Thus, researches on sulfur based cathode material focus on how to improve the conductivity and cyclability of materials solve the solubility problem of polysulfides as discharge products.", "Chinese patent application CN101891930A provides a sulfur composite cathode material containing carbon nanotube, sulfur is embedded in the composite.", "The battery has enhanced capacity.", "But, the battery with high cost and complex process is not suitable for industrialization due to the use of high costly carbon nanotube." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention aims to provide an electrode composite material with high capacity and reversible electrochemical performance.", "Accordingly to one aspect, the invention provides an electrode composite material comprising AB x C y D z , A being selected from at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer B being selected from sulfur; C being selected from carbon based materials; D being selected from metal oxides; 1≤x≤20, 0≤y<1, and 0≤z<1.Preferably, y=0, 0<z<1.Preferably, 0<y<1, 0<z<1.Preferably, the polyacrylonitrile copolymer is selected from at least one of polyacrylonitrile methylmethacrylate copolymer, and polyacrylonitrile polypyrrole copolymer.", "Preferably, the carbon based material is selected from at least one of ketjen black, Acetylene black, active carbon, single wall carbon nano-tube, multi wall carbon nano-tube and graphene.", "Preferably, the metal oxide is selected from at least one of Mg a Ni b O, MgO, NiO, V 2 O 5 , CuO, Mg c Cu d O, La 2 O 3 , Zr 2 O 3 , Ce 2 O 3 , and Mn 2 O f ; 0<a<1, 0<b<1, a+b=1; 0<c<1, 0<d<1, c+d=1; the value of f is 2 or 3 or 4 or 7.Accordingly to one aspect, the invention provides a cathode for battery, comprising the electrode composite material described above.", "Accordingly to one aspect, the invention provides a battery, comprising a cathode, an anode and an electrolyte provided between the cathode and anode, the cathode comprising a cathode current collector and the electrode composite material described above.", "Preferably, the electrolyte is selected from one of polyvinylidene fluoride, polyvinylidene fluoride-poly(methyl methacrylate) copolymer, polyvinylidene fluoride-hexafluoropropylene copolymer, and polyethylene glycol boric acid ester polymers.", "Preferably, the cathode current collector is selected from one of Aluminum foil, Nickel foam, and stainless steel net.", "Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising the following steps: dispersing sulfur in a first solvent to get a first solution; adding at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer into a second solvent to get a second solution; mixing the first solution, the second solution and at least one of a metal oxide by ball milling in an inert atmosphere to get a mixture; drying the mixture to remove the solvents therein; and then, heat-treating the mixture in a protective gas, cooling to get the electrode composite material; the first solvent being selected from one of carbon disulfide, toluene, and liquid hydrocarbon; the second solvent being selected from one of dimethylformamide, dimethyl acrylamide, a mixture of dimethyl acrylamide and lithium chloride, and dimethyl sulfoxide.", "Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising the following steps: dispersing sulfur in a first solvent to get a first solution; soaking carbon based material into the first solution and vacuum drying to remove the solvent therein to get a first mixture; mixing the first mixture, at least one of a metal oxide, at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer by ball milling in an inert atmosphere to get a second mixture; vacuum drying the second mixture to remove the solvents therein; heat-treating the second mixture in a protective gas and then cooling to get the electrode composite material; the first solvent being selected from one of carbon disulfide, toluene, and liquid hydrocarbon.", "Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising the following steps: dispersing sulfur in a first solvent to get a first solution; soaking carbon based material into the first solution and vacuum drying to remove the solvent therein to get a first mixture; adding at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer into a second solvent to get a second solution; mixing at least one of a metal oxide, the first mixture and the second solution by ball milling in inert atmosphere to get a second mixture; drying the second mixture to remove the solvents therein; heat-treating the second mixture in a protection gas, then cooling to get the electrode composite material; the first solvent being selected from one of carbon disulfide, toluene, and liquid hydrocarbon; the second solvent being selected from one of dimethylformamide, dimethyl acrylamide, a mixture of dimethyl acrylamide and lithium chloride, and dimethyl sulfoxide.", "Preferably, the metal oxide is Mg a Ni b O, 0<a<1, 0<b<1, a+b=1.Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising the following steps: mixing at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer, and at least one of metal oxides in solvent to get a first mixture; ball milling the first mixture to get a second mixture, vacuum drying the second mixture, and then heat-treating in protective gas or vacuum atmosphere, cooling to get the electrode composite material.", "Preferably, the metal oxide comprises a mixture of MgO and NiO, or a mixture of MgO and CuO.", "Preferably, the rotation speed range of the ball milling is 200-1300 rpm, the duration of ball milling is 0.5-12 h. Preferably, the temperature of the heat-treating is 150-450° C., the duration of the heat-treating is 1-20 h. Preferably, the temperature of the vacuum drying is 35-75° C., the duration of the vacuum drying time is 3-12 h. Preferably, the protective gas is selected from one of Ar, N 2 , a reductive gas mixture of Ar and H 2 , and a reductive gas mixture of N 2 and H 2 .", "The method provided in the present invention for preparing an electrode composite material comprises solution method and mechanical ball milling, so that each component of the electrode composite material can be more uniformly dispersed.", "The conductivity and electrochemical performance of sulfur based electrode composite material is obviously enhanced due to the addition of carbon based material and metal oxides.", "Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising element sulfur, at least one of polyacrylonitrile and polyacrylonitrile copolymer, comprising the following steps: Mixing sulfur, at least one of polyacrylonitrile and polyacrylonitrile copolymer, the resultant being heat-treated in an inert gas or vacuum atmosphere at the temperature range of 250-350° C., for no less than 1 h, then the electrode composite material being obtained.", "Preferably, the polyacrylonitrile copolymer is selected from at least one of polyacrylonitrile methylmethacrylate copolymer and polyacrylonitrile polypyrrole copolymer.", "Preferably, the weight ratio range of sulfur in the electrode composite material is 70-80%.", "Preferably, the weight ratio of sulfur and at least one of polyacrylonitrile and polyacrylonitrile copolymer is 4:1.Preferably, the inert gas is selected from Ar, or N 2 .", "Preferably, the sulfur and at least one of polyacrylonitrile and polyacrylonitrile copolymer are manually mixed.", "Preferably, the duration of manual mixing is 1-30 minutes.", "Ball milling which is time and energy consuming is skipped from the method provided in the present invention for preparing the electrode composite material, which prevent the structure of polymer from damaging.", "The method is simple and easy to operate, and the electrode composite material prepared thereby exhibits excellent property.", "Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising element sulfur and polyacrylonitrile, comprising the following steps: Sulfur and polyacrylonitrile being mechanically mixed, then dried in a vacuum atmosphere, the resultant being heat-treated in an inert gas or a vacuum atmosphere at 250-350° C. for 0.5-4 h, then the electrode composite material being obtained.", "Preferably, the mechanical mixing is conducted by ball milling.", "Preferably, the duration of the heat-treatment is 2.5 h. Preferably, the weight ration of sulfur and polyacrylonitrile is 4:1.Preferably, the temperature of vacuum drying is 50-80° C. Preferably, the duration of vacuum drying is 1-3 hours.", "The electrode composite material obtained by the method in the present invention exhibits excellent electrochemical properties and thermal stability, and the method is simple and suitable for industrialization.", "Accordingly to one aspect, the Invention provides a method for preparing an electrode composite material comprising element sulfur and polypyrrole, comprising the following steps: Sulfur and polypyrrole being mechanically mixed, and then the electrode composite material being obtained.", "Preferably, Sulfur has a nano or micro particles.", "Preferably, polypyrrole has a branched nanostructure.", "Preferably, the diameter distribution range of polypyrrole is 25-150 nm.", "Preferably, the duration of ball-milling is 1-6 h. Preferably, the rotation speed of the ball-milling is 200-1200 rpm.", "Preferably, polypyrrole is synthesized as described below: pyrrole monomer is added into the cetyltrimethylammonium bromide solution, and stirred.", "Subsequently, aqueous solution of ammonium persulfate is added, and the solution is stirred for 12-24 h. All synthesis procedures are carried out at a temperature range between 0-5° C. The final precipitate of PPy is separated via filtration, thoroughly washed and then dried.", "Preferably, the drying is carried out in a vacuum atmosphere.", "Preferably, the temperature range of the drying is 50-100° C. Preferably, the duration of the drying is 12-24 h. The method of preparing the electrode composite material provided in the present invention comprises a simple one-step ball-milling without heat-treatment which may cause the loss of sulfur.", "As a result, the utilization of the electrode composite material is improved and the method process is simplified, the method provided in the present invention for preparing lithium ion battery with high performance sulfur based cathode has promising prospect." ], [ "FIELD OF THE INVENTION The present invention relates to an electrode composite material, a method for preparing the electrode composite material, a cathode containing the electrode composite material, as well as battery containing the electrode composite material.", "BACKGROUND OF THE INVENTION With the development of technology, energy especially renewable green energy is in great demand.", "Batteries as energy storage and conversion device are playing an irreplaceable role.", "Lithium-ion batteries are leading power sources due to their high weight and volume specific energy.", "The development of lithium-ion battery focuses on low cost, high energy density, long cycle life and green environmental protection.", "Currently, the commercialized cathode material is lithium Intercalation compounds with a layer structure (lithium cobalt oxide), spinel structure (lithium manganese oxide) or olivine structure.", "Lithium cobalt oxide (LiCoO2) has high theoretical capacity of 275 mAh/g, along with high cost and toxicity, and its character of easy decomposition during overcharge may cause dramatically decrease of battery capacity and safety issues.", "Lithium manganese oxide (LiMn2O4) with theoretical capacity of 148 mAh/g, actually less than 130 mAh/g, is unstable, of which the crystal structure may deform during the charging and discharging process, resulting in low cycling efficiency; lithium Iron phosphate (LiFePO4) with theoretical capacity of 172 mAh/g has poor conductivity and reducing reversible capacity.", "The above conventional lithium-ion battery cathode materials cannot satisfy the requirement of battery development due to their capacity and some other problems.", "Theoretical capacity of elemental sulfur is 1675 mAh/g which is much higher than those of commercialized cathode materials.", "The battery composed of sulfur and metal lithium has theoretical specific energy of 2600 mAh/g which is the main stream in battery development.", "Cathode materials containing elemental sulfur, sulfur-containing inorganic sulfides, organic sulfides, organic disulfides, organic polysulfides, or carbon-sulfur have been wildly researched by now, but some problems still exist therein.", "Firstly, conductive agents have to be added due to the poor conductivity of sulfur and sulphide; secondly, solubility of polysulfides as discharge products in electrolyte may affect the cyclability of battery.", "Thus, researches on sulfur based cathode material focus on how to improve the conductivity and cyclability of materials solve the solubility problem of polysulfides as discharge products.", "Chinese patent application CN101891930A provides a sulfur composite cathode material containing carbon nanotube, sulfur is embedded in the composite.", "The battery has enhanced capacity.", "But, the battery with high cost and complex process is not suitable for industrialization due to the use of high costly carbon nanotube.", "SUMMARY OF THE INVENTION The present invention aims to provide an electrode composite material with high capacity and reversible electrochemical performance.", "Accordingly to one aspect, the invention provides an electrode composite material comprising ABxCyDz, A being selected from at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer B being selected from sulfur; C being selected from carbon based materials; D being selected from metal oxides; 1≤x≤20, 0≤y<1, and 0≤z<1.Preferably, y=0, 0<z<1.Preferably, 0<y<1, 0<z<1.Preferably, the polyacrylonitrile copolymer is selected from at least one of polyacrylonitrile methylmethacrylate copolymer, and polyacrylonitrile polypyrrole copolymer.", "Preferably, the carbon based material is selected from at least one of ketjen black, Acetylene black, active carbon, single wall carbon nano-tube, multi wall carbon nano-tube and graphene.", "Preferably, the metal oxide is selected from at least one of MgaNibO, MgO, NiO, V2O5, CuO, MgcCudO, La2O3, Zr2O3, Ce2O3, and Mn2Of; 0<a<1, 0<b<1, a+b=1; 0<c<1, 0<d<1, c+d=1; the value of f is 2 or 3 or 4 or 7.Accordingly to one aspect, the invention provides a cathode for battery, comprising the electrode composite material described above.", "Accordingly to one aspect, the invention provides a battery, comprising a cathode, an anode and an electrolyte provided between the cathode and anode, the cathode comprising a cathode current collector and the electrode composite material described above.", "Preferably, the electrolyte is selected from one of polyvinylidene fluoride, polyvinylidene fluoride-poly(methyl methacrylate) copolymer, polyvinylidene fluoride-hexafluoropropylene copolymer, and polyethylene glycol boric acid ester polymers.", "Preferably, the cathode current collector is selected from one of Aluminum foil, Nickel foam, and stainless steel net.", "Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising the following steps: dispersing sulfur in a first solvent to get a first solution; adding at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer into a second solvent to get a second solution; mixing the first solution, the second solution and at least one of a metal oxide by ball milling in an inert atmosphere to get a mixture; drying the mixture to remove the solvents therein; and then, heat-treating the mixture in a protective gas, cooling to get the electrode composite material; the first solvent being selected from one of carbon disulfide, toluene, and liquid hydrocarbon; the second solvent being selected from one of dimethylformamide, dimethyl acrylamide, a mixture of dimethyl acrylamide and lithium chloride, and dimethyl sulfoxide.", "Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising the following steps: dispersing sulfur in a first solvent to get a first solution; soaking carbon based material into the first solution and vacuum drying to remove the solvent therein to get a first mixture; mixing the first mixture, at least one of a metal oxide, at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer by ball milling in an inert atmosphere to get a second mixture; vacuum drying the second mixture to remove the solvents therein; heat-treating the second mixture in a protective gas and then cooling to get the electrode composite material; the first solvent being selected from one of carbon disulfide, toluene, and liquid hydrocarbon.", "Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising the following steps: dispersing sulfur in a first solvent to get a first solution; soaking carbon based material into the first solution and vacuum drying to remove the solvent therein to get a first mixture; adding at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer into a second solvent to get a second solution; mixing at least one of a metal oxide, the first mixture and the second solution by ball milling in inert atmosphere to get a second mixture; drying the second mixture to remove the solvents therein; heat-treating the second mixture in a protection gas, then cooling to get the electrode composite material; the first solvent being selected from one of carbon disulfide, toluene, and liquid hydrocarbon; the second solvent being selected from one of dimethylformamide, dimethyl acrylamide, a mixture of dimethyl acrylamide and lithium chloride, and dimethyl sulfoxide.", "Preferably, the metal oxide is MgaNibO, 0<a<1, 0<b<1, a+b=1.Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising the following steps: mixing at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer, and at least one of metal oxides in solvent to get a first mixture; ball milling the first mixture to get a second mixture, vacuum drying the second mixture, and then heat-treating in protective gas or vacuum atmosphere, cooling to get the electrode composite material.", "Preferably, the metal oxide comprises a mixture of MgO and NiO, or a mixture of MgO and CuO.", "Preferably, the rotation speed range of the ball milling is 200-1300 rpm, the duration of ball milling is 0.5-12 h. Preferably, the temperature of the heat-treating is 150-450° C., the duration of the heat-treating is 1-20 h. Preferably, the temperature of the vacuum drying is 35-75° C., the duration of the vacuum drying time is 3-12 h. Preferably, the protective gas is selected from one of Ar, N2, a reductive gas mixture of Ar and H2, and a reductive gas mixture of N2 and H2.The method provided in the present invention for preparing an electrode composite material comprises solution method and mechanical ball milling, so that each component of the electrode composite material can be more uniformly dispersed.", "The conductivity and electrochemical performance of sulfur based electrode composite material is obviously enhanced due to the addition of carbon based material and metal oxides.", "Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising element sulfur, at least one of polyacrylonitrile and polyacrylonitrile copolymer, comprising the following steps: Mixing sulfur, at least one of polyacrylonitrile and polyacrylonitrile copolymer, the resultant being heat-treated in an inert gas or vacuum atmosphere at the temperature range of 250-350° C., for no less than 1 h, then the electrode composite material being obtained.", "Preferably, the polyacrylonitrile copolymer is selected from at least one of polyacrylonitrile methylmethacrylate copolymer and polyacrylonitrile polypyrrole copolymer.", "Preferably, the weight ratio range of sulfur in the electrode composite material is 70-80%.", "Preferably, the weight ratio of sulfur and at least one of polyacrylonitrile and polyacrylonitrile copolymer is 4:1.Preferably, the inert gas is selected from Ar, or N2.Preferably, the sulfur and at least one of polyacrylonitrile and polyacrylonitrile copolymer are manually mixed.", "Preferably, the duration of manual mixing is 1-30 minutes.", "Ball milling which is time and energy consuming is skipped from the method provided in the present invention for preparing the electrode composite material, which prevent the structure of polymer from damaging.", "The method is simple and easy to operate, and the electrode composite material prepared thereby exhibits excellent property.", "Accordingly to one aspect, the invention provides a method for preparing an electrode composite material comprising element sulfur and polyacrylonitrile, comprising the following steps: Sulfur and polyacrylonitrile being mechanically mixed, then dried in a vacuum atmosphere, the resultant being heat-treated in an inert gas or a vacuum atmosphere at 250-350° C. for 0.5-4 h, then the electrode composite material being obtained.", "Preferably, the mechanical mixing is conducted by ball milling.", "Preferably, the duration of the heat-treatment is 2.5 h. Preferably, the weight ration of sulfur and polyacrylonitrile is 4:1.Preferably, the temperature of vacuum drying is 50-80° C. Preferably, the duration of vacuum drying is 1-3 hours.", "The electrode composite material obtained by the method in the present invention exhibits excellent electrochemical properties and thermal stability, and the method is simple and suitable for industrialization.", "Accordingly to one aspect, the Invention provides a method for preparing an electrode composite material comprising element sulfur and polypyrrole, comprising the following steps: Sulfur and polypyrrole being mechanically mixed, and then the electrode composite material being obtained.", "Preferably, Sulfur has a nano or micro particles.", "Preferably, polypyrrole has a branched nanostructure.", "Preferably, the diameter distribution range of polypyrrole is 25-150 nm.", "Preferably, the duration of ball-milling is 1-6 h. Preferably, the rotation speed of the ball-milling is 200-1200 rpm.", "Preferably, polypyrrole is synthesized as described below: pyrrole monomer is added into the cetyltrimethylammonium bromide solution, and stirred.", "Subsequently, aqueous solution of ammonium persulfate is added, and the solution is stirred for 12-24 h. All synthesis procedures are carried out at a temperature range between 0-5° C. The final precipitate of PPy is separated via filtration, thoroughly washed and then dried.", "Preferably, the drying is carried out in a vacuum atmosphere.", "Preferably, the temperature range of the drying is 50-100° C. Preferably, the duration of the drying is 12-24 h. The method of preparing the electrode composite material provided in the present invention comprises a simple one-step ball-milling without heat-treatment which may cause the loss of sulfur.", "As a result, the utilization of the electrode composite material is improved and the method process is simplified, the method provided in the present invention for preparing lithium ion battery with high performance sulfur based cathode has promising prospect.", "BRIEF DESCRIPTION OF THE DRAWINGS The features of the Invention will become more apparent in the following detailed description in which reference is made to the appended drawings wherein: FIG.", "1 shows the XRD spectra of sulfur, KB and the composites S/KB and PAN/S/KB; FIG.", "2 shows the SEM image of the composite material PAN/S; FIG.", "3 shows the SEM image of the composite material PAN/S/Mg0.6Ni0.4O; FIG.", "4 shows the SEM images of the composite material PAN/S/KB/Mg0.6Ni0.4O; FIG.", "5 shows the cyclic voltammetry curves of the batteries provided in example 4 and 5; FIG.", "6 shows the charge-discharge profiles of the battery containing S/PAN composite cathode at 0.2 C provided in example 4; FIG.", "7 shows the charge-discharge profiles of the battery containing PAN/S/Mg0.6Ni0.4O composite cathode at 0.2 C provided in example 5; FIG.", "8 shows the AC impedance plots of S/PAN composite provided in example 4 and PAN/S/Mg0.6Ni0.4O composite provided in example 5; FIG.", "9 shows the capacity retention data for the battery containing PAN/S/Mg0.6Ni0.4O composite cathode at 0.2 C provided in example 5; FIG.", "10 shows the charge-discharge profiles of the battery at 0.2 C provided in example 6; FIG.", "11 shows the XRD spectra of the starting components S, Mg0.6Ni0.4O, and PAN/S/KB/Mg0.6Ni0.4O composite; FIG.", "12 shows the galvanostatic charge-discharge profiles of the battery containing PAN/S/KB/Mg0.6Ni0.4O composite cathode at 0.2 C provided in example 9; FIG.", "13 shows cyclability data along with the cycling efficiency at 0.5 C for batteries containing PAN/S/KB/Mg0.6Ni0.4O composite provided in example 5 and PAN/S/Mg0.6Ni0.4O composite provided in example 9; FIG.", "14 shows the rate capability data for the batteries containing PAN/S/KB/Mg0.6Ni0.4O composite provided in example 5 and PAN/S/Mg0.6Ni0.4O composite provided in example 9; FIG.", "15 shows the capacity retention data for the battery at 0.2 C provided in example 11; FIG.", "16 shows the XRD patterns of pure S, pure PPy and PPy/S composite; FIG.", "17 shows the TEM data of PPy/S composite; FIG.", "18 shows the CV curves of the batteries containing PPy/S composite, S and PPy, used as a cathode active material in the lithium half-battery provided in example 21, comparative example 1 and 2; FIG.", "19 shows the initial profiles of galvanostatic charge-discharge tests of the battery with PPy/S composite cathode provided in example 21; FIG.", "20 shows the cyclability of batteries provided in example 21 and comparative example 1; FIG.", "21 shows AC impedance behavior of the batteries containing S and PPy/S cathode provided in example 21 and comparative example 1; FIG.", "22 shows SEM images of the PAN/S composite without heat treatment; FIG.", "23 shows SEM images of the PAN/S composite with heat treatment; FIG.", "24 shows the charge/discharge profiles of the battery at 0.2 C provided in example 23; FIG.", "25 shows the charge/discharge profiles of the battery provided in comparative example 3 at 0.2 C; FIG.", "26 shows the cycle ability of the battery provided in example 23; FIG.", "27 shows the cycle ability of the battery provided in comparative example 3; FIG.", "28 shows the cycle ability of the battery containing PAN/S composite provided in example 23 at different current density; FIG.", "29 shows the FTIR spectra of PAN and the composites provided in the example 24-26 and comparative example 4; FIG.", "30 shows the surface morphology of the composite S/DPAN provided in example 26 by FE-SEM; FIG.", "31 shows the surface morphology of the composite S/PAN provided in comparative example 4 by FE-SEM; FIG.", "32 shows the thermal behavior of S, PAN, composites S/DPAN and S/PAN by TG-DTA and its time derivative DTG; FIG.", "33 shows the thermal behavior of S/PAN composites provided in example 24-26 and comparative example 4; FIG.", "34 shows the variation of specific discharge capacity at 5th cycle upon changing the heat treatment time, at 0.2 C; FIG.", "35 shows the CV curves of the battery provided in example 25 with the scanning rate of 0.1 mV/s; FIG.", "36 shows the charge/discharge profiles of the battery provided in example 25 at the 1st, 2nd, 5th and 10th cycles; FIG.", "37 shows the cycle ability of the battery provided in example 25.DETAILED DESCRIPTION OF THE INVENTION In one aspect, the present invention provides an electrode composite material with high capacity and good electrochemical reversibility.", "An electrode comprises ABxCyDz, A is selected from at least one of polypyrrole (PPy), polyacrylonitrile (PAN) and polyacrylonitrile copolymer; B is element sulfur; C is selected from carbon based material; D is selected from metal oxides; wherein, 1≤x≤20, 0≤y<1, and 0≤z<1.Polyacrylonitrile copolymer is selected from at least one of polyacrylonitrile methylmethacrylate copolymer and PAN-PPy copolymer.", "PPy with excellent conductivity is wildly used in the surface modification of electrode and electrode materials.", "The pyrolysis reaction of PAN at 200-300° C. comprises the process of cyclization of nitrile groups, dehydrogenation, conjugating and cross-linking etc., and conjugated polypyrrole with excellent conductivity is formed.", "The low temperature pyrolysis nature of PAN provides a good support for the preparation of electrode composite material.", "Both PAN-methyl methacrylate copolymer with PAN unit and PAN-Ppy combined with the double properties of PAN and Ppy could be used as a support for the electrode composite material.", "Meanwhile, the content of A in the electrode composite material is no more than 20% by weight.", "Specifically, A is PAN.", "Carbon based material is selected from at least one of ketjen black (KB), acetylene black, active carbon, single wall carbon nanotube, multi-wall carbon nanotube and graphene.", "Carbon based materials are generally characterized by a large surface area, strong adsorption function, and the excellent electrical conductivity, which is suitable as a conductive additive.", "According to one embodiment, carbon based material is KB.", "The particle size of KB is about 30 nm, while along with high specific surface area of 1400 m2/g and a strong adsorption capacity.", "The addition of KB not only improve the conductivity of material, but also effectively restrain the agglomeration of composite during the preparation process due to its large specific surface area and strong adsorption capacity, which ensure that the composite has smaller particle size and uniformly distribute.", "So the diffusion path of lithium ions is shortened and the conductivity of composite is improved.", "In addition, the cost of KB is relatively cheap; the cost of the composite electrode containing KB is also low and of practicality.", "Metal oxides comprises at least one of MgaNibO, MgO, NiO, V2O5, CuO, MgcCudO, La2O3, Zr2O3, Ce2O3 and Mn2Of, wherein, 0<a<1, 0<b<1, a+b=1; 0<c<1, 0<d<1, c+d=1; the value of f is 2 or 3 or 4 or 7.More specifically, MgaNibO comprises but not limited to Mg0.6Ni0.4O; MgcCudO comprises but not limited to Mg0.8Cu0.2O.", "The improved conductivity of the electrode composite material and the suppression of dissolving of intermediate product polysulfides are due to the addition of metal oxides, which improve the utilization of sulfur and cycle ability of battery.", "According to one embodiment, the metal oxides comprise a mixture of MgO and NiO, or a mixture of MgO and CuO.", "For the electrode composite material, the effect of mixture containing MgO and NiO and mixture containing MgO and CuO may equal to that of Mg0.6Ni0.4O and Mg0.6Cu0.2O, but the mixture containing MgO and NiO, or MgO and CuO is superior in preparation technique.", "Though element sulfur has high theoretical capacity, sulfur is an electron and ion insulator at room temperature.", "Lithium-sulfur battery containing sulfur as cathode is impossible charged and discharged at room temperature.", "Therefore, an electron and ion conductor must be added into the sulfur cathode.", "The sulfur-containing electrode composite provided in the present invention aims to improve the conductivity of sulfur-containing electrode composite material, and also improve the capacity and cycle ability of the electrode.", "According to one aspect of the invention, an electrode composite ABxCyDz, A is selected from at least one of polypyrrole (PPy), polyacrylonitrile (PAN) and polyacrylonitrile copolymer; B is element sulfur; C is selected from carbon based material; D is selected from metal oxides; wherein, 1≤x≤20, 0<y<0, and 0<z<1.According to one aspect of the invention, an electrode composite ABxCyDz, A is selected from at least one of polypyrrole (PPy), polyacrylonitrile (PAN) and polyacrylonitrile copolymer; B is element sulfur; C is selected from carbon based material; D is selected from metal oxides; wherein, 1≤x≤20, 0<y<1, and 0<z<1.According to one embodiment, the electrode composite material comprises a binary composite PAN/S containing PAN and S. According to a preferable embodiment, the electrode composite material comprises a ternary composite PAN/S/KB containing PAN, S and KB.", "According to a more preferable embodiment, the electrode composite material comprises a quaternary composite PAN/S/KB/Mg0.6Ni0.4O containing PAN, S, KB and metal oxides.", "Disclosed is a cathode for battery, the electrode composite material described above used as cathode active material is combined with a cathode current collector to form the cathode.", "Disclosed is a battery, comprising a cathode, an anode and an electrolyte between the cathode and anode.", "The cathode comprises a cathode current collector and a cathode active material.", "The cathode active material comprises the electrode composite material described above; the weight rate range of the electrode composite material in the cathode active material is 50-90%, wherein the cathode further comprises a conductive agent and a binder.", "Preferably, the electrode composite material in the cathode active material is 80% by weight.", "The conductive agent comprises at least one of conductive polymer, active carbon, graphene, carbon black, carbon fibre, metal fibre, metal powder and metal sheet.", "In a preferable embodiment, the conductive agent is KB.", "The binder comprises one of polyethylene oxide, polypropylene oxide, polyacrylonitrile, polyimides, polyesters, polyethers, fluorinated polymers, polydivinyl polyethylene glycol, polyethylene glycol diacrylate, polyethylene glycol dimethacrylate, a combination thereof and derivatives.", "In one embodiment, the binder is polyvinylidene fluoride (PVDF).", "The weight rate range of the binder in the cathode active material is 1-30%.", "The cathode current collector comprises but not limited to one of nickel foam, aluminum foil, and stainless steel net.", "Preferably, the cathode current collector is nickel foam.", "The anode comprises an anode current collector and an anode active material which comprises but not limited to one of metal lithium, lithium alloys, lithium carbide and silicon based material.", "The anode current collector comprises but not limited to copper foil, copper net, aluminum foil, nickel foam and stainless steel net.", "When the anode active material is lithium, lithium itself can be used as an anode current collector.", "Lithium alloys include lithium-aluminum alloy, lithium-magnesium alloy and lithium-tin alloy; carbon based material in the lithium carbide comprises but not limited to one of crystalline carbon, amorphous carbon, and a mixture thereof.", "Silicon based material is selected from at least one of silicon, silicon alloy, silicon coated with metal, silicon doped with metal.", "Silicon alloy comprises silicon-carbon alloy, silicon-lithium alloy and silicon-manganese.", "In order to improve the electron conductivity, silicon is coated or doped with metal which comprises but not limited to copper, tin and silver.", "According to an embodiment, silicon coated with metal is 3D porous silicon coated with silver.", "In order to ensure that lithium ions exist in the cathode or anode in the process of charge and discharge, cathode or anode should be pre-intercalated with lithium ions if sulfur based cathode and silicon based anode contains no lithium ions.", "The method of pre-intercalating treatment comprises but not limited to chemical reaction and electrochemical reaction.", "Electrolyte at least comprises a lithium salt and a mixed organic solvent.", "According to a embodiment, 1 M LIPF6 in a solution of ethylene carbonate (EC):dimethyl carbonate (DMC):diethylene carbonate (DEC) is used as a liquid electrolyte.", "The lithium salts comprise but not limited to lithium hexafluorophosphate (LiPFe), lithium tetrafluoroborate (LiBF4), lithium perchlorate (LiClO4), lithium trifluoromethanesulfonate (LiCF3SO3), bistrifluoromethanesulfonimide lithium salt (LiN(CF3SO2)2).", "The addition of lithium salts in electrolyte can effectively increase the ionic conductivity of the electrolyte.", "The solvent of electrolyte can be a normal organic solvent, for example, dimethoxy ethane (DME), ethylene carbonate (EC), diethylene carbonate (DEC), propylene carbonate (PC), 1, 3-dioxolane (DIOX), ether, Bis(2-methoxy ethyl)ether, lactone, Sulfone, Sulfolane or a mixture thereof.", "Moreover, the solvent can be a polymer, such as polyvinylidene difluoride (PVDF), polyvinylidene difluoride-polymethylmethacrylate copolymer (PVDF-PMMA), polyvinylidene difluoride hexafluoropropylene copolymer (PVDF-HFP), polyethylene glycol borate esters (PEG-borate esters).", "Electrolyte in gel state is helpful for preventing the leakage of electrolyte and avoiding environmental contamination, along with improving the safety of the battery.", "In one aspect of the invention, a separator may be provided with the battery structure.", "In such case, the separator may comprise an organic or inorganic porous material.", "In one aspect, the separator has a porosity of 20-95% and includes pores having a pore size of 0.001-100 μm.", "In one aspect of the invention, the cathode slurry is prepared by mixing the electrode composite material, KB as conductive agent, PVDF as binder with organic solvent as dispersant.", "The cathode slurry is spread onto the surface of the cathode current collector by any means which can provide a substantially uniform coating layer thereon, such as doctor blade method, wired draw rod method, screen printing method or others.", "The solvent in the cathode slurry can be removed by evaporation under normal or low pressure and ambient or elevated temperature, the removal speed of solvent is preferably kept substantially constant along the surface of the slurry.", "Then, CR2032 coin battery is assembled with the obtained cathode, anode, electrolyte and a separator.", "According to one aspect of the present invention, a series of methods for preparing the electrode composite material ABxCyDz is provided.", "Preparation methods are simple and easy to industrialization, while the electrode composite materials prepared thereby have excellent electrochemical properties that can be used in the electrochemical devices, such as battery.", "Three methods for preparing the electrode composite material ABxCyDz are provided, wherein y=0, z=0.Method 1 A method for preparing an electrode composite material comprising element sulfur, at least one of polypyrrole, polyacrylonitrile and polyacrylonitrile copolymer, comprises the following steps.", "Sulfur and at least one of polypyrrole, polyacrylonitrile and polyacrylonitrile copolymer are mixed, the resultant is heat-treated in an inert gas or a vacuum atmosphere, the temperature range of heat-treatment is 250-350° C., the duration of heat-treatment is no less than 1 h, then the electrode composite material is obtained.", "The weight ratio of sulfur in the electrode composite material is 70-80%, more specifically, the weight ratio of sulfur and at least one of PAN and PAN copolymer is 4:1.The inert gas is selected from Ar or N2.In an embodiment, the electrode composite material is heat-treated in Ar gas.", "Specifically, sulfur and at least one of PAN and PAN copolymer are manually mixed; the duration of manual mixing is 1-30 minutes, preferably, 2-3 minutes.", "Specifically, the resultant is heat-treated at 3001 for 3 h. Traditional method for preparing sulfur based electrode composite material includes mechanical mixing, such as ball milling which is time/energy consuming and may affect the structure of electrode composite material, especially material with polymer, for the long chain structure of the polymer could break.", "The mechanical mixing process is skipped from the method provided in the present invention for preparing the electrode composite material.", "The method is easy to operate and prevent the electrode composite material from adverse effect.", "The electrode composite material prepared by the method disclosed in the present invention could be used as a cathode material, further, may be used for preparing battery with cathode containing the electrode composite material.", "The method provided in the present invention for preparing the electrode composite material is simple, suitable for industrialization and without adverse influence in respect of material structure and property.", "The electrode composite material obtained by the method in the present invention exhibits excellent electrochemical properties, which greatly accelerate the commercialization of the battery.", "Method 2 A method for preparing an electrode composite material comprising element sulfur and polyacrylonitrile, comprises the following steps.", "Sulfur and polyacrylonitrile are mechanically mixed, then dried in a vacuum atmosphere, the resultant is heat-treated in an inert gas or a vacuum atmosphere, the temperature range of heat-treatment is 250-350° C., the duration of heat-treatment is 0.5-4 h, then the electrode composite material is obtained.", "The mechanical mixing is conducted by ball milling.", "The vacuum drying temperature is 50-80° C. for 1-3 h. More specifically, S and PAN are mixed in weight ratio of S/PAN=4:1 by ball-milling for 5 h with ethanol as dispersant.", "The resulted mixtures are dried at 50° C. for 3 h in vacuum oven and then annealed at 300° C. for 0.5-4 h. Preferably, the annealing time is 2.5 h. The electrode composite material obtained by the method in the present invention exhibits excellent electrochemical property and thermal stability, and the method is simple and suitable for industrialization.", "Method 3 A method for preparing an electrode composite material comprising element sulfur and polypyrrole, comprises the following steps.", "Sulfur and polypyrrole are mechanically mixed, and then the electrode composite material is obtained.", "Sulfur has a nano or micro particles.", "According to an embodiment, the average particle size of the sulfur is 150 micron.", "Polypyrrole has a branched nanostructure with diameter distribution range of 25-150 nm.", "PPy and sulfur are mixed by ball milling, specifically, PPy is mixed with S in the weight ratio PPy:S=1:2 by ball-milling for 1-6 h at 200-1200 rpm.", "According to an embodiment, PPy is mixed with S by ball-milling for 3 h at 600 rpm.", "Polypyrrole is synthesized as described below: pyrrole monomer is added into the cetyltrimethylammonium bromide (CTAB) solution, and stirred.", "Subsequently, aqueous solution of ammonium persulfate (Sigma-Aldrich, 98% purity) is added, and the solution is stirred for 12-24 h. All synthesis procedures are carried out in a temperature range between 0-5° C. The final precipitate of PPy is separated via filtration, thoroughly washed and then dried.", "Specifically, pyrrole monomer is added into an aqueous solution with cationic surfactant CTAB and vigorously stirred to make the pyrrole monomer dissolved.", "Subsequently, ammonium persulfate is added, as an oxidizing agent, to initiate the polymerization, and the solution is stirred for 24 h. The final precipitate of PPy is separated via filtration, thoroughly washed with deionized water and ethanol for high purity of PPy.", "The resulted PPy is dried after being washed.", "Specifically, PPy is dried in a vacuum atmosphere at 50-100° C. According to an embodiment, the drying temperature is 70° C. for 12-24 h, 12 h is preferable.", "Though element sulfur has a high theoretical capacity, sulfur is an electron and ion insulator at room temperature, lithium-sulfur battery containing 100% content sulfur as cathode is impossible charged and discharged at room temperature.", "PPy with excellent conductivity is wildly used in the surface modification of electrode and as electrode materials.", "The electrode composite material S/PPy is prepared via the method provided in the present invention has excellent electrochemical performance.", "Branched conductive PPy matrix with nanostructure is uniformly coated with S, which enhance the conductivity of PPy/S.", "Furthermore, the branched structure of the nanocomposite and high porosity of the PPy matrix could hinder the polysulfide dissolution and improve the utilization of S. The method provided in the present invention is simple and heat-treatment is exclusive to avoid the sulfur loss.", "Thus, the method disclosed in the present invention for preparing the electrode composite S/PPy is suitable for industrial application in the battery containing the electrode composites.", "The electrode composite S/PPy is prepared by a simple one-step ball-milling without heat-treatment.", "This method is economical, environmentally friendly, for the exclusion of the heat treatment process may reduce the loss of sulfur and avoid the generation of harmful sulphide.", "The electrochemical performance is significantly enhanced of battery composed of this composite S/PPy and a liquid electrolyte, which is equal to that composed of sulfur based cathode containing expensive carbon materials prepared by complex process.", "Accordingly, the method provided in the present invention for preparing lithium ion battery with high performance sulfur based cathode has promising prospect.", "Two methods for preparing the electrode composite material ABxCyDz are provided, wherein y=0, 0<z<1.Method 1 A method for preparing an electrode composite material comprises the following steps.", "disperse sulfur in a first solvent to get a first solution; add at least one of polypyrrole, polyacrylonitrile and polyacrylonitrile copolymer into a second solvent to get a second solution; mix the first solution, the second solution, and at least one of metal oxides by ball milling in inert atmosphere to get a mixture; dry the mixture to remove the solvents therein; then, the mixture is heat-treated in a protective gas, and cooled naturally.", "Then, the electrode composite material is obtained; the first solvent is selected from one of carbon disulfide, toluene and liquid hydrocarbon; the second solvent is selected from one of dimethylformamide, dimethyl acrylamide, a mixture containing dimethyl acrylamide and lithium chloride, and dimethyl sulfoxide.", "The first solution, the second solution, and at least one of metal oxides are mixed uniformly by ball milling at 200-1300 rpm for 1-20 h. The ball milling is conducted in an inert gas to avoid side reaction.", "Specifically, the metal oxides comprise MgaNibO, wherein, 0<a<1, 0<b<1, a+b=1.According to an embodiment, the metal oxide is Mg0.6Ni0.4O.", "After being dried, the mixture is further heat treated at 150-450° C. for 1-20 h. The protective gas comprises Ar, N2, a reductive gas mixture of Ar and H2, and a reductive gas mixture of N2 and H2.According to one aspect of this method, S is dissolved in the organic solvent of CS2, and then mixed with DMF solution of PAN and Mg0.6Ni0.4O by ball milling in Ar gas.", "All mixtures (precursors) are dried in a vacuum oven to remove the solvents and then heat treated, and then cooled to get the electrode composite material.", "Method 2 A method for preparing an electrode composite material comprises the following steps.", "Mix sulfur, at least one of polypyrrole, polyacrylonitrile and polyacrylonitrile copolymer, and at least one of metal oxides in solvent to get a first mixture, ball mill the first mixture to get a second mixture, vacuum dry the second mixture, and then heat-treat in a protective gas or vacuum atmosphere, cool to get the electrode composite material.", "Preferably, the weight ratio range of sulfur in precursors is 60-95%, while polymer of polypyrrole, polyacrylonitrile, polyacrylonitrile copolymer, or a combination thereof is 2-40%, and the metal oxide is 0-20%.", "The solvent comprises but not limited to ethanol or N-methyl-2-pyrrolidone (NMP).", "According to a specific embodiment, metal oxide comprises Mg0.6Ni0.4O, or Mg0.8Cu2O.", "Preferably, metal oxide is a mixture of MgO and NiO, or a mixture of MgO and CuO.", "The ball milling is carried out at rotation speed of 200-1300 rpm for 1-20 h. In the process of drying, the temperature range is 150-450° C. for no less than 1 h. Preferably, the temperature range is 250-400° C. for 1-20 h. The drying is carried out in a protective gas or vacuum atmosphere.", "The protective gas comprises Ar or N2.According to an aspect of this method, sulfur, PAN and Mg0.6Ni0.4O are dissolved in ethanol as dispersant to get a first mixture, and then ball milled to get a second mixture.", "The second mixture is vacuum dried and heat treated at 300° C. for 3 h, then cooled to get the electrode composite material PAN/S/Mg0.6Ni0.4O.", "Two methods for preparing the electrode composite material ABxCyDz are provided, wherein 0<y<1, 0<z<1.Method 1 A method for preparing an electrode composite material comprises the following steps.", "disperse sulfur in a first solvent to get a first solution; soak a carbon based material into the first solution and vacuum dry to remove the solvent therein to get a first mixture; mix the first mixture, at least one of metal oxides, at least one of polypyrrole, polyacrylonitrile and polyacrylonitrile copolymer by ball milling in an inert atmosphere to get a second mixture; vacuum dry the second mixture to remove the solvents therein; heat-treat the second mixture in a protective gas and then cool to get the electrode composite material; the first solvent is selected from one of carbon disulfide, toluene and liquid hydrocarbon.", "The first mixture, at least one of metal oxides, at least one of polypyrrole, polyacrylonitrile, and polyacrylonitrile copolymer are uniformly mixed by ball milling at 200-1300 rpm for 1-20 h. The ball milling is conducted in an inert gas to avoid the side reaction.", "The metal oxide comprises MgaNibO, wherein 0<a<1, 0<b<1, a+b=1.Specifically, the metal oxide is Mg0.6Ni0.4O.", "The second mixture is vacuum dried at 35-75° C. for 3-12 h. After being vacuum dried, the second mixture is further heat treated at 150-450° C. for 1-20 h. The protective gas comprises Ar, N2, a reductive gas mixture of Ar and H2, or a reductive gas mixture of N2 and H2.According to one aspect of this method, sulfur is dissolved in organic solvent CS2 with KB, then vacuum dried to remove the solvent CS2 to get the first mixture.", "Then the first mixture, PAN and Mg0.6Ni0.4O are mixed by ball milling in Ar gas, the resultant is vacuum dried to remove the solvent, and then heat treated in N2 gas.", "After cooling the electrode composite material is obtained.", "Method 2 A method for preparing an electrode composite material comprises the following steps.", "disperse sulfur in a first solvent to get a first solution; soak a carbon based material into the first solution and vacuum dry to remove the solvent therein to get a first mixture; add at least one of polypyrrole, polyacrylonitrile and polyacrylonitrile copolymer into a second solvent to get a second solution; mix at least one of metal oxides, the first mixture, the second solution by ball milling in an inert atmosphere to get a second mixture; dry the second mixture to remove the solvents therein; heat-treat the second mixture in a protection gas, then cool to get the electrode composite material; the first solvent is selected from one of carbon disulfide, toluene, and liquid hydrocarbon; the second solvent is selected from one of dimethylformamide, dimethyl acrylamide, a mixture of dimethyl acrylamide and lithium chloride and dimethyl sulfoxide.", "The first mixture, at least one of metal oxides and the second solution are uniformly mixed by ball milling at 200-1300 rpm for 1-20 h. The ball milling is conducted in an inert gas to avoid the side reaction.", "The metal oxide comprises MgaNibO, wherein 0<a<1, 0<b<1, a+b=1.Specifically, metal oxide is Mg0.6Ni0.4O.", "The second mixture is vacuum dried at 35-75° C. for 3-12 h. After being vacuum dried, the second mixture is further heat-treated at 150-450° C. for 1-20 h. The protective gas comprises Ar, N2, a reductive gas mixture of Ar and H2, and a reductive gas mixture of N2 and H2.According to one aspect of this method, sulfur is dissolved in the organic solvent CS2 with KB, then vacuum dried to remove the solvent CS2 to get the first mixture, and then mixed with DMF solution of PAN and Mg0.6Ni0.4O by ball milling in Ar gas, the resultant is vacuum dried to remove the solvent, and then heat treated.", "After being cooled, the electrode composite material is obtained.", "The methods provided in the present invention for preparing an electrode composite material comprise solution method, mechanical ball milling, drying and heat treatment, so that each component of the electrode composite material can be more uniformly dispersed with smaller size, while the particle size of the electrode composite material is also smaller.", "Aspects of the present invention are described below by means of various illustrative examples.", "EXAMPLES Example 1 4 g S is dissolved in 30 cm3 of CS2, then is mixed with the PAN solution in dimethyl formamide (DMF) and dried in a vacuum oven at 65° C. for 3 h to remove the solvents and then heat treated at 350° C. for 3 h in a tubular furnace in Ar gas to make sulfur melt and react with PAN, then cooled to prepare the binary S/PAN composite.", "During the preparation process, the weight ratio of composite precursors (before heat treatment) is S:PAN=4:1.FIG.", "1 shows the XRD spectra of sulfur, KB and the composite PAN/S/KB prepared via mechanical and solution routes.", "It can be seen that the characteristic peaks of sulfur disappear in the composite S/KB and PAN/S/KB, and sublimed sulfur precipitates in highly crystallized form when cooled to the ambient temperature, which can be an indication of that element sulfur in melting state can be trapped into the carbon based grid and pores of PAN, and partially participate in bonding reaction to form sulfur based composite.", "The samples are weighted before and after heat treatment, which shows about 10 wt.", "% loss of sulfur during heating.", "FIG.", "2 shows the SEM image of the prepared binary composite PAN/S.", "One can see that the binary composite PAN/S has a smooth surface, due to element sulfur in melting state can being trapped into the carbon based grid and pores of PAN, and partially participating in bonding reaction to form sulfur based composite.", "Example 2 4 g S is dissolved in 30 cm3 of CS2, then is mixed with the PAN solution in DMF by ball milling at 800 rpm for 2 h with Mg0.8Ni0.4O, and dried in a vacuum oven at 65° C. for 3 h to remove the solvents and then heat treated at 350° C. for 3 h in a tubular furnace in Ar gas, then cooled to prepare the ternary composite PAN/S/Mg0.6Ni0.4O.", "During the preparation process, the weight ratio of composite precursors (before heat treatment) is S:PAN:Mg0.6Ni0.4O=4:1:0.3.FIG.", "3 shows the SEM image of the prepared ternary composite PAN/S/Mg0.6Ni0.4O.", "One can see that the surface morphology of the binary composite PAN/S is quite different from that of the ternary composite PAN/S/Mg0.6Ni0.4O.", "The ternary composite PAN/S/Mg0.6Ni0.4O surface is rough and consists of many agglomerated nanosized particles, which could enhance the materials reactivity via increasing the available reactive surface area of the composite.", "Also, this morphology change could be due to the formation of the surface layer of Mg0.6Ni0.4O, which could stabilize the material surface and consequently enhance the electrochemical stability of the ternary composite PAN/S/Mg0.6Ni0.Example 3 4 g S is dissolved in 30 cm3 of CS2 with KB, and dried in a vacuum oven to remove the solvent CS2, then mixture of S/KB is obtained.", "PAN is dissolved in DMF, then is mixed with the mixture of S/KB by ball milling at 800 rpm for 2 h with Mg0.6Ni0.4O, and dried in a vacuum oven at 65° C. for 3 h to remove the solvents and then heat treated at 350° C. for 3 h in a tubular furnace in Ar gas, then cooled to prepare the quaternary composite PAN/S/KB/Mg0.6Ni0.4O.", "During the preparation process, the weight ratio of composite precursors (before heat treatment) is S:PAN:KB:Mg0.6Ni0.4O=4:1:0.25:0.25.FIG.", "4 presents the SEM images of the quaternary composite PAN/S/KB/Mg0.6Ni0.4O.", "The addition of KB leads to the electronic conductivity improvement and prevents the agglomeration of the material during ball milling.", "One can see from FIG.", "4 that the addition of KB into the sulfur-polymer composite leads to the reduced agglomeration of the quaternary composite nanoparticles compared with the ternary system.", "Therefore, along with the electronic conductivity enhancement, the addition of KB could favour the enhanced ionic conductivity of the quaternary composite as well due to the reduced lithium diffusion paths within the smaller particles of the cathode material.", "Example 4 Sulfur polymer composite cathode is prepared by mixing 80 wt.", "% of S/PAN, composite as an active material, 10 wt.", "% ketjen black (KB) as a conductor, and 10 wt.", "% polyvinylidene fluoride (PVDF) as a binder dissolved in N-methyl-2-pyrrolidine (NMP) and coating the resulting slurry on a nickel foam using doctor blade technique.", "The composite cathode is dried thereafter at 50° C. for 24 h in a vacuum oven.", "After drying, the composite cathode was cut into circles.", "Coin-type batteries of CR2032 are assembled in an Ar-filled glove box by stacking a porous polypropylene separator containing 1 M LiPF6 EC:DMC:DEC=1:1:1 (by volume) as liquid electrolyte between the cathode and lithium metal anode.", "The battery is discharged and charged galvanostatically at the same current density between 1.0 V and 3.0 V vs. Li+/Li at various C rates at room temperature.", "Example 5 Sulfur polymer composite cathode is prepared by mixing 80 wt.", "% of PAN/S/Mg0.6Ni0.4O composite as an active material, 10 wt.", "% KB as a conductor, and 10 wt.", "% PVDF as a binder dissolved in NMP and coating the resulting slurry on a nickel foam using doctor blade technique.", "The composite cathode is dried thereafter at 50° C. for 24 h in a vacuum oven.", "After drying, the composite cathode was cut into circles.", "Coin-type batteries of CR2032 are assembled in an Ar-filled glove box by stacking a porous polypropylene separator containing 1 M LIPF6 EC:DMC:DEC=1:1:1 (by volume) as liquid electrolyte between the cathode and lithium metal anode.", "FIG.", "5 shows the cyclic voltammetry curves of the batteries provided in example 4 and 5, respectively.", "It can be seen that the addition of Mg0.6Ni0.4O leads to the enhanced electrochemical response of the cathode material.", "The Mg0.6Ni0.4O added ternary composite PAN/S/Mg0.6Ni0.4O has 2 well-separated reduction peaks accompanied with an oxidation peak in the reverse scan in the CV curves.", "The corresponding peaks of the binary S/PAN composite are weaker and broader.", "FIGS.", "6 and 7 show the charge-discharge profiles of battery at 0.2 C provided in example 4 and 5.It can be clearly seen that the kinetic improvement and the polarization decrease achieved in the system by the addition of Mg0.6Ni0.4O could be very beneficial for the utilization of low-conductive sulfur active material in the composite cathode and could play a remarkable role in the improvement of the energy and power density of the battery.", "The test result shows that the potential plateau of the ternary composite PAN/S/Mg0.6Ni0.4O becomes relatively flattened compared with that of the binary composite S/PAN, and the voltage gap between charge and discharge decreases, indicating improved electrochemical kinetics of the cathode with PAN/S/Mg0.6Ni0.4O.", "A specific capacity of 650 mAh/g of battery in example 5 is delivered in the first discharge, and a reversible capacity of 540 mAh/g is obtained in the second cycle.", "FIG.", "8 shows the AC impedance plots of a binary S/PAN and ternary PAN/S/Mg0.6Ni0.4O composites.", "The comparison of the AlS spectra of the composite cathodes shows that the impedance of ternary PAN/S/Mg0.6Ni0.4O composite is smaller than that of binary S/PAN.", "FIG.", "9 shows the capacity retention data for the battery provided in example 5 with ternary PAN/S/Mg0.6Ni0.4O composite cathode at 0.2 C upon prolonged cycling.", "The capacity retention is high and remains above 80% of the initial capacity even after 450 cycles.", "Example 6 A battery is made according to a method similar to that described in example 5.However, in this case, aluminum foil is used as cathode current collector.", "FIG.", "10 shows the charge-discharge profiles of battery at 0.2 C provided in example 6.The test result shows that the potential plateau become relatively flattened compared with that of FIG.", "7, and the voltage gap between charge and discharge decrease, indicating improved electrochemical performance of the cathode with PAN/S/Mg0.6Ni0.4O.", "Example 7 A battery is made according to a method similar to that described in example 5.However, in this case, 1 M LiPF6 EC:DMC:DEC=1:1:1 (by volume) soaked in polymer PVDF-HFP is used as electrolyte.", "Example 8 A battery is made according to a method similar to that described in example 5.However, in this case, 1 M LiPF6 EC:DMC:DEC=1:1:1 (by volume) soaked in polymer polyethylene glycol boric acid ester is used as electrolyte.", "Example 9 Sulfur polymer composite cathode is prepared by mixing 80 wt.", "% of PAN/S/KB/Mg0.6Ni04O composite as an active material, 10 wt.", "% KB as a conductor, and 10 wt.", "% PVDF as a binder dissolved in NMP and coating the resulting slurry on a nickel foam using doctor blade technique.", "The composite cathode is dried thereafter at 50° C. for 24 h in a vacuum oven.", "After drying, the composite cathode was cut into circles.", "Coin-type batteries of CR2032 are assembled in an Ar-filled glove box by stacking a porous polypropylene separator containing 1 M LiPF6 EC:DMC:DEC=1:1:1 (by volume) as liquid electrolyte between the cathode and lithium metal anode.", "FIG.", "11 shows the XRD spectra of the starting components S, Mg0.6Ni0.4O, PAN/S/KB/Mg0.6Ni0.4O.", "It can be seen from FIG.", "11 that the peaks of Mg0.6Ni0.4O remain in the composite PAN/S/KB/Mg0.6Ni0.4O, which could be considered as an indication that Mg0.6Ni0.4O is kept in the composite cathode without remarkable structural changes.", "FIG.", "12 presents the galvanostatic charge-discharge profiles of the battery with quaternary PAN/S/KB/Mg0.6Ni0.4O composite cathode at 0.2 C. It can be seen that the potential plateau becomes relatively flattened compared with that of FIG.", "7, and the voltage gap between charge and discharge decreases; the addition of Mg0.4Ni0.6O leads to the improvement of cathode conductivity and the reduction of electrode polarization; besides, the particle sizes of the KB-added composite compared with the S/PAN/Mg0.6Ni0.4O composite are remarkably reduced, due to the improved electronic conductivity of the cathode and the agglomeration reduction effect of KB, which shorten the diffusion path of Lithium ion and make the battery charged faster.", "FIG.", "13 shows cyclability data along with the cycling efficiency at 0.5 C for batteries with PAN/S/KB/Mg0.6Ni0.4O and PAN/S/Mg0.6Ni0.4O composites respectively.", "It can be seen that both cathodes exhibit excellent cycling efficiency, and the KB added composites PAN/S/KB/Mg0.6Ni0.4 shows improved discharge capacity compared with the ternary composite PAN/S/Mg0.6Ni0.4.FIG.", "14 shows the rate capability data for batteries with PAN/S/KB/Mg0.6Ni0.4O and PAN/S/Mg0.6Ni0.4O composites respectively.", "It can be seen that the discharge capacity of battery with PAN/S/KB/Mg0.6Ni0.4O composite cathode is more than that of battery with PAN/S/Mg0.6Ni0.4O composite cathode, which can be an indication that the electrochemical performance of composite cathode could be remarkably improved by the addition of KB.", "Battery with PAN/S/KB/Mg0.6Ni0.4O composite cathode delivers a stabilized discharge capacity of about 410 mAh/g compared with 320 mAh/g of the battery with ternary PAN/S/Mg0.6Ni0.4O cathode with about 100% capacity retention over 40 cycles at 0.5 C galvanostatic charge-discharge.", "Example 10 A battery is made according to a method similar to that described in example 9.However, in this case, aluminum foil is used as cathode current collector.", "Example 11 A battery is made according to a method similar to that described in example 9.However, in this case, 1 M LIPF6 EC:DMC:DEC=1:1:1 (by volume) soaked in polymer PVDF-HFP is used as electrolyte.", "FIG.", "15 shows the capacity retention data for the battery provided in example 11 at 0.2 C. It can be seen that the fading of capacity of battery is relatively slow after two cycles, and the discharge capacity is recovered at 20th cycles.", "Example 12 A battery is made according to a method similar to that described in example 9.However, in this case, 1 M LiPF6 EC:DMC:DEC=1:1:1 (by volume) soaked in polymer polyethylene glycol boric acid ester is used as electrolyte.", "Example 13 Element S, PAN and Mg0.6Ni0.4O are mixed in weight ratio of S/PAN/Mg0.6Ni0.4O=4:1:0.25 by ball-milling for 5 h with ethanol as dispersant.", "The resulted mixtures are dried at 50° C. for 3 h in vacuum oven and then annealed at 300° C. for 3 h in Ar atmosphere.", "Finally, ternary PAN/S/Mg0.6Ni0.4O composite is obtained.", "S based cathode is prepared by making slurry of 80 wt.", "% PAN/S/Mg0.6Ni0.4O as an active material, 10 wt.", "% ketjen black as a conductor and 10 wt.", "% polyvinylidene fluoride (PVDF) binder in NMP.", "The resulted slurry is spread onto a nickel foam and vacuum dried at 50° C. for 12 h, then pressed using a rolling machine to get the cathode plate.", "Separator used here is a porous polypropylene membrane.", "1 M LIPF6 in a solution of ethylene carbonate (EC):dimethyl carbonate (DMC):diethylene carbonate (DEC) (EC:DMC:DEC volume ratio=1:1:1) is used as a liquid electrolyte.", "The CR2032 coin battery is assembled in a gloved box filled with high purity Ar.", "Example 14 A battery is made according to a method similar to that described in example 13.However, in this case, Mg0.8Cu0.2O is used instead of Mg0.6Ni0.4O to prepare ternary PAN/S/Mg0.8Cu0.2O composite and CR2032 coin battery with ternary PAN/S/Mg0.8Cu0.2O composite cathode.", "Example 15 A battery is made according to a method similar to that described in example 13.However, in this case, mixture of MgO and NiO is used instead of Mg0.6Ni0.4O to prepare ternary PAN/S/MgO+NiO composite and CR2032 coin battery with ternary PAN/S/MgO+NiO composite cathode.", "The weight ratio of MgO and NiO is 6:4.Example 16 A battery is made according to a method similar to that described in example 13.However, in this case, mixture of MgO and CuO is used instead of Mg0.6Ni0.4O to prepare ternary PAN/S/MgO+CuO composite and CR2032 coin battery with ternary PAN/S/MgO+CuO composite cathode.", "The weight ratio of MgO and CuO is 8:2.Example 17 A battery is made according to a method similar to that described in example 13.However, in this case, MgO is used instead of Mg0.6Ni0.4O to prepare ternary PAN/S/MgO composite and CR2032 coin battery with ternary PAN/S/MgO composite cathode.", "Example 18 A battery is made according to a method similar to that described in example 13.However, in this case, NiO is used instead of Mg0.6Ni0.4O to prepare ternary PAN/S/NiO composite and CR2032 coin battery with ternary PAN/S/NiO composite cathode.", "Example 19 A battery is made according to a method similar to that described in example 13.However, in this case, CuO is used instead of Mg0.6Ni0.4O to prepare ternary PAN/S/CuO composite and CR2032 coin battery with ternary PAN/S/CuO composite cathode.", "Then, the batteries in example 13-19 are tested.", "The batteries are charged and discharged galvanostatically at 0.2 C (1 C=1672 mAh/g) between 1 and 3 V at room temperature.", "Specific capacities and current densities are calculated based on the amount of S in cathode, which could be identified by using an elemental analyzer.", "The electrochemical performance of batteries is presented in table 1.The coulombic efficiency of batteries in example 13-19 is nearly 100% after 35 cycles.", "Battery in example 13 shows the best discharge capacity and discharge capacity retention.", "The equivalent electrochemical performances of batteries in example 14-17 indicate that the addition of MgO is the main reason for improvement of cyclability.", "Of the batteries in example 17-19, the battery in example 17 shows the best electrochemical performance.", "Batteries in example 13 and 15 show the equivalent performance, so do the batteries in example 14 and 16, which can be the indication that the effect of mixture of MgO and NiO is equal to Mg0.6Ni0.4O and MgO and CuO is equal to Mg0.8Cu0.2O.", "Nevertheless, the method of preparing the mixture of MgO/NiO and MgO/CuO is more simple and economic than that of Mg0.6Ni0.4O and Mg0.8Cu0.2O.", "TABLE 1 Discharge Cathode Discharge capacity Coulombic active capacity retention efficiency material Anode Eectrolyte Voltage (mAh/g) (%) (%) Example 13 PAN/S/Mg0.6Ni0.4O Li LiPF6 1-3 V 1250 96 ~100 EC/DEC/DMC Example 14 PAN/S/Mg0.8Cu0.2O 1125 88 Example 15 PAN/S/MgO + 1100 92 NiO Example 16 PAN/S/MgO + 1150 86.7 CuO Example 17 PAN/S/MgO 1104 95 Example 18 PAN/S/NiO 1026 85.6 Example 19 PAN/S/CuO 1058 82.2 12.4 g cetyltrimethylammonium bromide (CTAB) (Sigma, ≥299.9% purity) is dissolved in 0.75 L deionized water, and then 0.015 L of pyrrole monomer (Aldrich, 98% purity) is added into the CTAB solution, stirred for 3 h. Subsequently, 0.045 L aqueous solution of 5.1 g ammonium persulfate (Sigma-Aldrich, 98% purity) is added, as an oxidizing agent, to initiate the polymerization, and the solution is stirred for 24 h. All synthesis procedures are carried out in a temperature range between 0-5° C. The final precipitate of PPy is separated via filtration, thoroughly washed with deionized water and ethanol, and then vacuum dried at 70° C. for 12 h. To make PPy/S composite, PPy is mixed with S (Sigma-Aldrich, 100-mesh particle size powder) in the weight ratio PPy:S=1:2, by ball-milling for 3 h at 600 rpm.", "The XRD patterns of pure S, pure PPy and PPy/S composite are shown in FIG.", "16.One can see that while PPy is amorphous.", "In comparison with S, the PPy/S composite shows sharp peaks of S with reduced peak intensity.", "On the other hand, no peak shift could be observed, which could be an indication of the absence of phase transformations due to ball milling, and the sulfur crystal structure remains in the PPy/S composite.", "However, the XRD peak intensity reduction may indicate partial absorption of melted sulfur, during ball-milling, into the porous structure of PPy, since ball-milling generates heat and the temperature increases over the melting point of sulfur.", "Chemical analysis has shown that the sulfur content in the PPy/S composite is about 65 wt %, i.e.", "there is no significant sulfur loss when the composite is prepared by the method in the present invention.", "The TEM data of PPy/S composite is presented in FIG.", "17 which shows that the PPy/S composite has a well-developed branched structure.", "Specific surface area of the as-prepared PPy is 129.8 m2/g with the pore volume of 0.55 cm3/g.", "After mixing with sulfur, the specific surface area of PPy/S is only 4.4 m2/g with the pore volume of 0.052 cm3/g.", "This remarkable specific surface area and pore size reduction of PPy/S composite could be mainly due to deposition of a large amount of sulfur into the pores and surface of PPy.", "The formation of the PPy/S composite with homogeneous sulfur deposition on the conductive PPy surface may drastically improve the conductivity of the composite cathode, which is important for the sulfur utilization and increase of the sulfur cathode capacity.", "Furthermore, the branched nanostructure of PPy/S could accommodate the volume change of the composite during charge and discharge and improve the cyclability of the composite cathode.", "A high S content cathode is desirable to construct a high energy density battery.", "Exclusion of the heat treatment from the synthetic route for the PPy/S composite along with saving energy and simplifying the preparation process prevents the sulfur loss due to its sublimation.", "This also prevents the generation of toxic volatile sulfur compounds at high temperature conditions; therefore, the preparation technique provided in the present invention could be more preferable than the conventional prolonged multi-step and high temperature techniques for preparation of conductive S-containing composites.", "Example 21 The electrochemical performance of PPy/S composite samples is investigated using coin-type batteries (CR2032).", "The composite cathode slurry is prepared by mixing 80 wt % PPy/S, 10 wt % PVdF (Kynar, HSV900) as a binder and 10 wt % acetylene black (MTI, 99.5% purity) conducting agent in NMP (Sigma-Aldrich, ≥99.5% purity).", "The resultant slurry in NMP is spread onto a circular piece of nickel foam (MTI, ≥99% purity) with 1 cm in diameter.", "After drying in a vacuum oven for 12 h at 60° C., the cathode is pressed at 8 MPa by a hydraulic press in order to achieve good contact between the active material and nickel foam.", "The electrodes are prepared to make their weight and thickness the same by precise weighing, pressing and controlling its geometry.", "The battery is composed of lithium metal anode and as prepared PPy/S cathode separated by a microporous polypropylene separator soaked in 1 mol/L solution of lithium bistrifluoromethanesulfonamide (LiTFSI) (Aldrich, 96% purity) in tetraethylene glycol dimethyl ether (Aldrich, 99% purity) electrolyte.", "The coin battery is assembled in a Braun glove box filled with high purity argon (99.9995% purity).", "Comparative Example 1 A battery is made according to a method similar to that described in example 21.However, in this case, the cathode is prepared by mixing 60 wt % S, 30 wt % acetylene black (MTI, 99.5% purity) conducting agent and 10 wt % PVdF as a binder.", "Comparative Example 2 A battery is made according to a method similar to that described in example 21.However, in this case, the cathode is prepared by mixing 60 wt % PPy, 30 wt % acetylene black (MTI, 99.5% purity) conducting agent and 10 wt % PVdF as a binder.", "The electrochemical performance of batteries in example 21, comparative example 1 and 2 is tested.", "The batteries are tested galvanostatically on a multichannel battery tester (BT-2000, Arbin Instruments) between 1 and 3 V vs. Li+/Li electrode at a current density of 100 mA/g.", "Applied currents and specific capacities are calculated on the basis of the weight of S in the cathode.", "Cyclic voltammetry (CV) and AC impedance spectroscopy (AIS) are performed with a potentiostat (VMP3, Biologic).", "CV is conducted between 1 and 3 V vs. Li+/Li at a scanning rate of 0.1 mV/s.", "The frequency of AC impedance is varied from 1 MHz to 1 Hz with applied voltage amplitude of 10 mV.", "All electrochemical measurements are performed at room temperature.", "The CV curves are shown in FIG.", "18 for batteries with PPy/S, S and PPy composite, used as a cathode active material in the lithium half-battery provided in example 21, comparative example 1 and 2.One can see that for pure S cathode in comparative example 1, one broad reduction peak is observed at about 1.5 V vs. Li+/Li, and the electrochemical processes are slow and poorly reversible.", "It can also be seen that battery with PPy composite cathode is electrochemically inactive at 1-3 V and there are no noticeable electrochemical processes observed.", "In the case of the battery with S/PPy composite cathode, two pairs of complex reversible redox peaks are observed around 2 and 2.5 V, which is possible due to the multi-step electrochemical reactions of S with Li+.", "The CV data reveals that PPy improves the electrochemical kinetics of S. The initial profiles of galvanostatic charge-discharge tests of the battery with PPy/S cathode provided in example 21 are shown in FIG.", "19.It can be seen that two main plateaus appear in the potential profiles, which could be attributed to two main electrochemical reactions taking place at sulfur cathode upon cycling in Li/S battery.", "The results are in good agreement with the CV data.", "The first electrochemical reaction is presented by a short discharge plateau about 2.5 V and related to the formation of higher-order lithium polysulfides (Li2Sn, n≥4), which are soluble in the liquid electrolyte.", "The following prolonged plateau around 2.0 V in the discharge profiles reflects the following electrochemical transition of the polysulfides to lithium sulfide Li2S, and this reaction kinetics is slower than that of the polysulfide formation.", "It could be seen that while the 2 V discharge plateaus had no remarkable difference between the first and third cycles, the higher voltage plateau diminishes and almost disappears after the third cycle.", "Discharge capacity of 1050 mAh/g is obtained at the third cycle.", "The cyclability of batteries provided in example 21 and comparative example 1 is showed in FIG.", "20.It can be seen that the battery with PPy/S composite cathode cyclability is remarkably enhanced compared with that of the S cathode.", "The discharge capacity of battery in example 21 has been stabilized after 25 cycles at about 600 mAh/g and a discharge capacity of 500 mAh/g is retained after 40 cycles.", "In contrast, the discharge capacity of battery in comparative example 1 drastically decreased with cycling.", "The battery with pure sulfur cathode has a discharge capacity of only about 110 mAh/g at the 40th cycle.", "AC Impedance behavior of the batteries with S and PPy/S cathode provided in example 21 and comparative example 1 is given in FIG.", "21.A much smaller high-to-medium frequency semicircle can be seen in the PPy/S cathode AIS spectra compared with that of the sulfur cathode in comparative example 1.This indicates a significant decrease in charge transfer resistance in the PPy/S composite, which may be due to the high conductivity polypyrrole.", "This charge transfer enhancement leads to the electrochemical performance improvement of the composite cathode.", "Example 22 Sulfur (Sigma-Aldrich, 100-mesh particle size powder), polyacrylonitrile (PAN) (Sigma-Aldrich) are mixed by hand for 2-3 minutes in the weight ratio of 4:1.All mixtures (precursors) are heat treated at 300° C. for 3 h in a tubular furnace in Ar gas to make sulfur melt and react with PAN.", "Then, PAN/S composite is obtained.", "The morphology of the composite PAN/S is characterized by scanning electron microscopy (SEM, FE-SEM LEO 1530).", "SEM images of composite PAN/S without heat treatment and with heat treatment are presented in FIGS.", "22 and 23, respectively.", "One can see that the size of the composite PAN/S without heat treatment is quite bigger than that of the composite PAN/S with heat treatment.", "The composite PAN/S surface is rough and consists of many agglomerated nano sized particles, which could enhance the PAN/S reactivity via increasing the available reactive surface area of the composite.", "Example 23 PAN/S composite cathode is prepared by mixing 80 wt.", "% of PAN/S composite as an active material, 10 wt.", "% ketjen black (MTI, 99.5% purity) as a conductor, and 10 wt.", "% polyvinylidene fluoride (PVDF) (Kynar, HSV900) as a binder dissolved in N-methyl-2-pyrrolidine (NMP) (Sigma-Aldrich, 299.5% purity).", "The resulting slurry is spread onto circular nickel foam with 1 cm diameter and then vacuum dried at 60° C. for 12 h, the cathode electrode is pressed at 8 MPa by a hydraulic presser in order to achieve good contact between the active material and nickel foam.", "1 M LiPF6 in a solution of ethylene carbonate (EC):dimethyl carbonate (DMC):diethylene carbonate (DEC) (EC:DMC:DEC volume ratio=1:1:1) is used as the liquid electrolyte.", "The separator used here is a porous polypropylene membrane.", "The battery is assembled in a gloved box filled with high purity Ar.", "Comparative Example 3 A battery is made according to a method similar to that described in example 23.However, in this case, ball milling is used for mixing the S and PAN instead of manual mixing.", "The electrochemical performance of batteries in example 23 and comparative example 3 is tested.", "The batteries are charged and discharged galvanostatically at 0.2 C (1 C=1672 mAh/g) between 1 and 3 V at room temperature.", "Specific capacities and current densities are calculated based on the amount of S in the cathode.", "FIGS.", "24 and 25 show the charge/discharge profiles of the batteries provided in example 23 and comparative example 3, respectively, at 0.2 C. From these figures we can see big difference, PAN/S without ball-milling delivered a stable discharge capacity at about 1300 mAh/g based on sulfur at the 5th cycle, which is higher than that of PAN/S with ball-milling (1000 mAh/g).", "FIGS.", "26 and 27 show the cycle ability of the batteries provided in example 23 and comparative example 3, respectively.", "It can be seen that battery with PAN/S composite without ball-milling in example 23 runs for longer cycle than battery with PAN/S composite with ball-milling.", "FIG.", "28 illustrates cycle ability of battery provided in example 23 at different current density.", "From FIG.", "28 we can see that after high current density it can recover, it means it can handle high current density.", "Example 24 Sulfur (Sigma-Aldrich, 100-mesh particle size) and PAN (Sigma-Aldrich, average MW=150,000) are mixed by ball milling (Fritsch, pulverisette 7) at a weight ratio of 4:1 for 5 h with ethanol as the dispersant.", "The resulting mixture is dried at 50° C. for 3 h in a vacuum oven and then annealed at 300° C. in Ar atmosphere.", "The heat treatment time is 0.5 h. Then, dehydrogenated S/DPAN composite is obtained.", "The electrochemical performance of the S/DPAN composite is investigated using coin-type battery (CR2032).", "The composite cathode comprised 80 wt % S/DPAN with 10 wt % ketjenblack (EC600JD, Akzo Nobel) and the rest with polyvinylidene fluoride (PVdF) (Kynar, HSV900) as the binder.", "These materials are dispersed in NMP (Sigma-Aldrich, ≥99.5% purity).", "The resultant slurry is spread uniformly onto a circular nickel foam disc of 1 cm in diameter, then dried in a vacuum oven at 50° C. for 12 h. The average weight of S/DPAN composite is about 10-12 mg per electrode.", "Lithium metal is used as anode, while a microporous polypropylene film is separator.", "1 M solution of LiPF6 in a mixed solvent of ethylene carbonate (EC), dimethyl carbonate (DMC), and diethylene carbonate (DEC) with 1:1:1 weight ratio (LP71, Merck Chemicals) is used as the liquid electrolyte.", "The coin battery is assembled in a Braun glove box filled with high purity argon gas.", "The battery is tested galvanostatically on a multi-channel battery tester (BT-2000, Arbin) between 1 and 3 V at 0.2 C charge/discharge rate (current density=334.4 mA/g).", "CV is conducted between 1 and 3 V vs. Li+/Li at a scanning rate of 0.1 mV/s.", "The electrochemical tests are conducted at ambient temperature.", "Example 25 A battery is made according to a method similar to that described in example 25.However, in this case, the heat treatment time is 2.5 h instead of 0.5 h. A battery is made according to a method similar to that described in example 24.However, in this case, the heat treatment time is 2.5 h instead of 0.5 h. Example 26 A battery is made according to a method similar to that described in example 24.However, in this case, the heat treatment time is 4 h instead of 0.5 h. Comparative Example 4 A battery is made according to a method similar to that described in example 24.However, in this case, heat treatment is excluded after ball mixing of S and PAN.", "FIG.", "29 shows the FTIR spectra of PAN and composites provided in example 24-26, comparative example 4.The characteristic peak at 2244 cm−1 represents the —CN group, and the one at 1455 cm−1 is related to the —CH2 group, in the FTIR spectrum of PAN.", "The spectra of S/PAN and PAN are similar, indicating that there is no reaction between sulfur and PAN during ball-milling.", "After 0.5 h of heat treatment, these characteristic peaks no longer exist and are replaced by new peaks.", "The peak at 1498 cm−1 represents the C═C double bond, and a —CH deformation is corresponded by a new peak at 1359 cm−1.The formation of the cyclic structure is reflected by the peaks at 1427 cm−1 and 803 cm−1.The peak intensity significantly increases when heat treatment time increases from 0.5 to 2.5 h, and then slightly changes when heat treatment temperature increases from 2.5 to 4 h. The later fact indicates that there is no significant chemical transformation between 2.5 h and 4 h. The surface morphologies of the composite S/PAN provided in example 26 and comparative example 4 are studied by FE-SEM as shown in FIGS.", "30 and 31, respectively.", "Both composites are aggregates consist of primary particles with particle sizes within 100-400 nm.", "However, their morphologies are quite distinguishable, indicating a major change during heat treatment.", "FIG.", "32 shows the thermal behavior of S, PAN, composites provided in example 26 and comparative example 4 which is studied by TG-DTA and its time derivative DTG.", "It can be seen from the figure that sufficient heat treatment time improves the thermal stability of the composites considerably, which can be ascribed to the formation of a highly stable structure in the composites.", "FIG.", "33 shows the thermal behavior of S/PAN composites provided in example 24-26 and comparative example 4.This is a further proof of improving thermal stability of the mixtures by increasing heat treatment time, and S/PAN composites after heat treatment time of 2.5 h and 4 h have almost the same thermal behaviour.", "FIG.", "34 presents the variation of specific discharge capacity at 5th cycle upon changing the heat treatment time, at 0.2 C. While almost no discharge capacity can be delivered by the S/PAN without heat treatment, annealing it for 0.5 h results in a specific discharge capacity of 370 mAh/g.", "The specific discharge capacity slightly increases with the heat treatment time of up to 1.5 h, and then drastically increases with the heat treatment time up to 2.5 h. For the heat treatment times longer than 2.5 h, the specific discharge capacity slightly decreased.", "There might be deterioration in the S/DPAN structure with further heat treatment.", "The black dots in FIG.", "34 represent discharge capacity based on the content of sulfur in the cathode, while the black frames represent discharge capacity based on the weight of composite.", "Henceforth, 2.5 h is the optimum heat treatment time.", "FIG.", "35 is CV curves of battery provided in example 25 with the scanning rate of 0.1 mV/s.", "FIG.", "36 shows the charge/discharge profiles of battery provided in example 25 at the 1st, 2nd, 5th and 10th cycles.", "FIG.", "37 shows the cyclability of the battery provided in example 25.Discharge capacity of the battery gradually decreases with cycle number.", "Reversible capacity retention of 81.7% can be achieved after 50 cycles at 0.2 C. Although the invention has been described with reference to certain specific embodiments, various modifications thereof will be apparent to those skilled in the art without departing from the purpose and scope of the invention as outlined in the claims appended hereto.", "Any examples provided herein are included solely for the purpose of illustrating the invention and are not intended to limit the invention in any way.", "Any drawings provided herein are solely for the purpose of illustrating various aspects of the invention and are not intended to be drawn to scale or to limit the invention in any way.", "The disclosures of all prior art recited herein are incorporated herein by reference in their entirety." ] ]
Patent_15874327
[ [ "CROSS FLOW FAN FOR WIDE AIRCRAFT FUSELAGE", "A cross flow fan to be incorporated into an aircraft fuselage comprises an ingestion fan rotor to be positioned in a tail section of an aircraft fuselage to reduce boundary layer air from a top surface of the fuselage and to drive the air away from the top surface, and a drive arrangement for the ingestion fan rotor.", "An aircraft is also disclosed." ], [ "1.A cross flow fan to be incorporated into an aircraft fuselage comprising: an ingestion fan rotor to be positioned in a tail section of an aircraft fuselage to reduce boundary layer air from a top surface of the fuselage and to drive the air away from the top surface; and a drive arrangement for said ingestion fan rotor.", "2.The cross flow fan as set forth in claim 1, wherein said drive arrangement is positioned at at least one axial end of the ingestion fan rotor.", "3.The cross flow fan as set forth in claim 2, wherein said drive arrangement drives said ingestion fan rotor through a bevel gear.", "4.The cross flow fan as set forth in claim 1, wherein said drive arrangement is positioned at an axially intermediate location on said ingestion fan rotor.", "5.The cross flow fan as set forth in claim 4, wherein said drive arrangement drives said ingestion fan rotor through a bevel gear.", "6.The cross flow fan as set forth in claim 1, wherein said drive arrangement incorporates at least one electric motor.", "7.The cross flow fan as set forth in claim 6, wherein at least two electric motors drive said ingestion fan rotor.", "8.The cross flow fan as set forth in claim 1, wherein said drive arrangement includes a gas turbine engine.", "9.The cross flow fan as set forth in claim 1, wherein said drive arrangement drives said ingestion fan rotor through a bevel gear.", "10.An aircraft comprising: an aircraft fuselage having a relatively wide cross-sectional area at a location forward of a tail; main gas turbine engines for driving the aircraft mounted at a location remote from said relatively wide portion of said fuselage; an ingestion fan rotor positioned at said wide cross-sectional area to reduce boundary layer air from a top surface of the fuselage and to drive the air away from the top surface; and a drive arrangement for said ingestion fan rotor.", "11.The aircraft as set forth in claim 10, wherein said drive arrangement is positioned on at least one axial end of the ingestion fan rotor.", "12.The aircraft as set forth in claim 11, wherein said drive arrangement drives said ingestion fan rotor through a bevel gear.", "13.The aircraft as set forth in claim 10, wherein said drive arrangement is positioned at an axially intermediate location on said ingestion fan rotor.", "14.The aircraft as set forth in claim 13, wherein said drive arrangement drives said ingestion fan rotor through a bevel gear.", "15.The aircraft as set forth in claim 8, wherein said drive arrangement incorporates at least one electric motor.", "16.The aircraft as set forth in claim 15, wherein at least two electric motors drive said ingestion fan rotor.", "17.The aircraft as set forth in claim 10, wherein said drive arrangement includes an ingestion gas turbine engine.", "18.The aircraft as set forth in claim 17, further comprising rear stabilizers extending upwardly from a fuselage body and connected to a tail, and said ingestion gas turbine engine is mounted in at least one of said stabilizers.", "19.The aircraft as set forth in claim 10, further comprising rear stabilizers extending upwardly from a fuselage body and connected to a tail, and said drive arrangement is mounted in at least one of said stabilizers.", "20.The aircraft as set forth in claim 10, wherein said drive arrangement drives said ingestion fan rotor through a bevel gear.", "21.The aircraft as set forth in claim 10, wherein there is a combined propulsion provided by said ingestion fan rotor and said main gas turbine engines in combination, and said ingestion fan rotor providing greater than or equal to about 10% and less than or equal to about 25% of the total propulsion.", "22.The aircraft as set forth in claim 10, wherein said relatively wide cross-section area has a width to height ratio greater than or equal to about 1.5." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Aircraft bodies have been proposed that have a so-called “double-bubble” fuselage near the tail.", "In such bodies, there are two part cylindrical sections on opposed sides, with an elongated intermediate section, such that the aircraft body is relatively wide.", "In such an aircraft body, boundary layer air along the wide fuselage creates drag issues.", "It is been proposed to place the gas turbine engines for the aircraft in the fuselage and forward of the tail to utilize this air as part of the air for the gas turbine engines.", "However, other engine locations may be desirable." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>This application relates to a cross flow fan to reduce boundary layer air that would otherwise create drag in proposed aircraft bodies having a relatively wide fuselage.", "In a featured embodiment, a cross flow fan to be incorporated into an aircraft fuselage comprises an ingestion fan rotor to be positioned in a tail section of an aircraft fuselage to reduce boundary layer air from a top surface of the fuselage and to drive the air away from the top surface, and a drive arrangement for the ingestion fan rotor.", "In another embodiment according to the previous embodiment, the drive arrangement is positioned at at least one axial end of the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another embodiment according to any of the previous embodiments, the drive arrangement is positioned at an axially intermediate location on the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another embodiment according to any of the previous embodiments, the drive arrangement incorporates at least one electric motor.", "In another embodiment according to any of the previous embodiments, at least two electric motors drive the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement includes an ingestion gas turbine engine.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another featured embodiment, an aircraft comprises an aircraft fuselage having a relatively wide cross-sectional area at a location forward of a tail.", "A main gas turbine engine drives the aircraft mounted at a location remote from the relatively wide portion of the fuselage.", "An ingestion fan rotor is positioned at the wide cross-sectional area to reduce boundary layer air from a top surface of the fuselage and to drive the air away from the top surface.", "A drive arrangement is provided for the ingestion fan rotor.", "In another embodiment according to the previous embodiment, the drive arrangement is positioned on at least one axial end of the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another embodiment according to any of the previous embodiments, the drive arrangement is positioned at an axially intermediate location on the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another embodiment according to any of the previous embodiments, the drive arrangement incorporates at least one electric motor.", "In another embodiment according to any of the previous embodiments, at least two electric motors drive the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement includes an ingestion gas turbine engine.", "In another embodiment according to any of the previous embodiments, rear stabilizers extend upwardly from a fuselage body and connect to a tail.", "The ingestion gas turbine engine is mounted in at least one of the stabilizers.", "In another embodiment according to any of the previous embodiments, rear stabilizers extend upwardly from a fuselage body and connect to a tail.", "The drive arrangement is mounted in at least one of the stabilizers.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another embodiment according to any of the previous embodiments, there is a combined propulsion provided by the ingestion fan rotor and the main gas turbine engines in combination.", "The ingestion fan rotor provides greater than or equal to about 10% and less than or equal to about 25% of the total propulsion.", "In another embodiment according to any of the previous embodiments, the relatively wide cross-section area has a width to height ratio greater than or equal to about 1.5.These and other features may be best understood from the following drawings and specification." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This disclosure is a continuation in part of U.S. patent application Ser.", "No.", "15/072,267 filed Mar.", "17, 2016.BACKGROUND OF THE INVENTION Aircraft bodies have been proposed that have a so-called “double-bubble” fuselage near the tail.", "In such bodies, there are two part cylindrical sections on opposed sides, with an elongated intermediate section, such that the aircraft body is relatively wide.", "In such an aircraft body, boundary layer air along the wide fuselage creates drag issues.", "It is been proposed to place the gas turbine engines for the aircraft in the fuselage and forward of the tail to utilize this air as part of the air for the gas turbine engines.", "However, other engine locations may be desirable.", "SUMMARY OF THE INVENTION This application relates to a cross flow fan to reduce boundary layer air that would otherwise create drag in proposed aircraft bodies having a relatively wide fuselage.", "In a featured embodiment, a cross flow fan to be incorporated into an aircraft fuselage comprises an ingestion fan rotor to be positioned in a tail section of an aircraft fuselage to reduce boundary layer air from a top surface of the fuselage and to drive the air away from the top surface, and a drive arrangement for the ingestion fan rotor.", "In another embodiment according to the previous embodiment, the drive arrangement is positioned at at least one axial end of the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another embodiment according to any of the previous embodiments, the drive arrangement is positioned at an axially intermediate location on the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another embodiment according to any of the previous embodiments, the drive arrangement incorporates at least one electric motor.", "In another embodiment according to any of the previous embodiments, at least two electric motors drive the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement includes an ingestion gas turbine engine.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another featured embodiment, an aircraft comprises an aircraft fuselage having a relatively wide cross-sectional area at a location forward of a tail.", "A main gas turbine engine drives the aircraft mounted at a location remote from the relatively wide portion of the fuselage.", "An ingestion fan rotor is positioned at the wide cross-sectional area to reduce boundary layer air from a top surface of the fuselage and to drive the air away from the top surface.", "A drive arrangement is provided for the ingestion fan rotor.", "In another embodiment according to the previous embodiment, the drive arrangement is positioned on at least one axial end of the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another embodiment according to any of the previous embodiments, the drive arrangement is positioned at an axially intermediate location on the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another embodiment according to any of the previous embodiments, the drive arrangement incorporates at least one electric motor.", "In another embodiment according to any of the previous embodiments, at least two electric motors drive the ingestion fan rotor.", "In another embodiment according to any of the previous embodiments, the drive arrangement includes an ingestion gas turbine engine.", "In another embodiment according to any of the previous embodiments, rear stabilizers extend upwardly from a fuselage body and connect to a tail.", "The ingestion gas turbine engine is mounted in at least one of the stabilizers.", "In another embodiment according to any of the previous embodiments, rear stabilizers extend upwardly from a fuselage body and connect to a tail.", "The drive arrangement is mounted in at least one of the stabilizers.", "In another embodiment according to any of the previous embodiments, the drive arrangement drives the ingestion fan rotor through a bevel gear.", "In another embodiment according to any of the previous embodiments, there is a combined propulsion provided by the ingestion fan rotor and the main gas turbine engines in combination.", "The ingestion fan rotor provides greater than or equal to about 10% and less than or equal to about 25% of the total propulsion.", "In another embodiment according to any of the previous embodiments, the relatively wide cross-section area has a width to height ratio greater than or equal to about 1.5.These and other features may be best understood from the following drawings and specification.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 shows a proposed aircraft body.", "FIG.", "2 is a cross-sectional view along line 2-2 of FIG.", "1.FIG.", "3 shows a cross flow fan.", "FIG.", "4 shows a drive arrangement embodiment for a cross flow fan.", "FIG.", "5A shows an alternative drive arrangement embodiment for a cross flow fan.", "FIG.", "5B shows a detail of the FIG.", "5A embodiment.", "FIG.", "6 shows yet another alternative embodiment for a cross flow fan.", "DETAILED DESCRIPTION FIG.", "1 shows an aircraft body 20 having a fuselage 22 and engines 24 mounted beneath wings 26.The aircraft body 20 is a so-called “double-bubble” aircraft body.", "Rear stabilizers 28 lead to a tail 30.A fuselage area 32 on top of the aircraft forward of the tail 30 is relatively wide and boundary layer air across the wide fuselage raises drag issues.", "As such, in this disclosure, an air intake 34 leads to a cross flow fan to energize this boundary layer air.", "FIG.", "2 is a cross-sectional view along line 2-2 of FIG.", "1.The fuselage is not generally cylindrical in cross section.", "This differs from the prior art conventional tube+wing aircraft in which the fuselage is basically a cylindrical tube.", "The noncylindrical fuselage has a horizontal width significantly greater than its vertical height.", "This configuration may be achieved with a double bubble, which is essentially two cylinders blended together in the horizontal direction, or more generally any elongated or elliptical cross section that has width to height ratio significantly greater than unity.", "In embodiments, the ratio is greater than or equal to about 1.5 The flattened non-cylindrical fuselage shape has several potential advantages.", "It has less external wetted surface area for a given number of passengers compared to the cylindrical cross section, thus lowering aerodynamic drag.", "The flattened fuselage shape may be able to carry some lift, thus reducing the amount of lift required from the wings and the associated wing area.", "A further advantage that pertains to the present invention is that the flattened fuselage may close out at the back end to a flat beavertail shape with a trailing edge of finite width.", "The fuselage boundary layer may then be ingested into a high aspect ratio rectangular “mail slot” inlet arranged near the trailing edge of the beavertail between the vertical stabilizers 28.As shown, the fuselage in the area 32 is not generally cylindrical in cross-section, as in the case in standard aircraft today.", "Rather, there are opposed semicircular portions 36 separated by a generally straight area 40.Thus, there are more circular sides and less curved central areas 40.As mentioned, this results in a wide fuselage and drag issues being raised.", "FIG.", "3 shows details of the intake 34.As shown, a top 42 of the fuselage is spaced above a fan 44.The fan is a transverse axis fan, also known as a crossflow fan.", "Fan 44 will drive the boundary layer air mentioned above to an outlet 45 rearward of the aircraft such that the drag issues mentioned above are reduced.", "FIG.", "4 shows the fan 44 being driven by electric motors 48.Motors 48 drive shafts 46 that drive the fan 44 through bevel gears 47.Due to the bevel gears 47, the motors 48 can be positioned off axis relative to the fan 44, and such that the fan 44 is able to remove the boundary layer air across the majority of the width of the fuselage section 32.That is, the motors 48 drive axial ends of fan rotor 44.While two electric motors are illustrated, it may be that only a single motor is necessary.", "FIG.", "5A shows an alternative wherein a fan rotor 52 is driven by a small gas turbine engine 54.A turbine drives a gear 56 to, in turn, drive the fan rotor 52 through a bevel gear arrangement.", "An air scoop 58 has an inlet 60 to bring air to the gas turbine engine 54.As shown in FIG.", "5B, the air inlet 60 and the engine 54 may be mounted in an axially intermediate location to drive the fan rotor 52.The gas turbine engine 54 may also be utilized as an auxiliary power unit (APU) to provide power and other functions associated with the aircraft.", "FIG.", "6 shows an alternative embodiment wherein the air intake 64 and also the gas turbine engine (not specifically illustrated) is mounted within the stabilizer 62.Such a location may also be utilized for the electric motor embodiment of FIG.", "4.The cross-flow fan across these embodiments will provide propulsion.", "Still, the bulk of the propulsion for the aircraft will come from the main gas turbine engines.", "In embodiments, the cross-flow fan may provide 10-25% of the overall propulsion provided in combination with the main gas turbine engines.", "Stated another way, there is a combined propulsion provided by the tail mounted fan rotor and the main gas turbine engines in combination.", "The fan rotor provides greater than or equal to about 10% and less than or equal to about 25% of the total propulsion.", "Although an embodiment of this invention has been disclosed, a worker of ordinary skill in this art would recognize that certain modifications would come within the scope of this invention.", "For that reason, the following claims should be studied to determine the true scope and content of this invention." ] ]
Patent_15874335
[ [ "DISULFIDE-LINKED POLYETHYLENEGLYCOL/PEPTIDE CONJUGATES FOR THE TRANSFECTION OF NUCLEIC ACIDS", "The present invention is directed to an inventive polymeric carrier molecule according to generic formula (I) and variations thereof, which allows for efficient transfection of nucleic acids into cells in vivo and in vitro, a polymeric carrier cargo complex formed by a nucleic acid and the inventive polymeric carrier molecule, but also to methods of preparation of this inventive polymeric carrier molecule and of the inventive polymeric carrier cargo complex.", "The present invention also provides methods of application and use of this inventive polymeric carrier molecule and the inventive polymeric carrier cargo complex as a medicament, for the treatment of various diseases, and in the preparation of a pharmaceutical composition for the treatment of such diseases." ], [ "1.Polymeric carrier molecule according to formula (I): L-P1—S—[S—P2—S]n—S—P3-L wherein, P1 and P3 are different or identical to each other and represent a linear or branched hydrophilic polymer chain, each P1 and P3 exhibiting at least one —SH-moiety, capable to form a disulfide linkage upon condensation with component P2, the linear or branched hydrophilic polymer chain selected independent from each other from polyethylene glycol (PEG), poly-N-(2-hydroxypropyl)methacrylamide, poly-2-(methacryloyloxy)ethyl phosphorylcholines, poly(hydroxyalkyl L-asparagine), poly(2-(methacryloyloxy)ethyl phosphorylcholine), hydroxyethylstarch or poly(hydroxyalkyl L-glutamine), wherein the hydrophilic polymer chain exhibits a molecular weight of about 1 kDa to about 100 kDa, P2 is a cationic or polycationic peptide or protein, having a length of about 3 to about 100 amino acids, or is a cationic or polycationic polymer, having a molecular weight of about 0.5 kDa to about 30 kDa, each P2 exhibiting at least two —SH-moieties, capable to form a disulfide linkage upon condensation with further components P2 or component(s) P1 and/or P3; S—S— is a (reversible) disulfide bond; L is an optional ligand, which may be present or not, and may be selected independent from the other from RGD, Transferrin, Folate, a signal peptide or signal sequence, a localization signal or sequence, a nuclear localization signal or sequence (NLS), an antibody, a cell penetrating peptide, TAT, a ligand of a receptor, cytokines, hormones, growth factors, small molecules, carbohydrates, mannose, galactose, synthetic ligands, small molecule agonists, inhibitors or a antagonists of receptors, or RGD peptidomimetic analogues; and n is an integer, selected from a range of about 1 to 50, preferably in a range of about 1, 2, 3, 4, or 5 to 10, more preferably in a range of about 1, 2, 3, or 4 to 9.2.The polymeric carrier molecule according to claim 1, wherein the polymeric carrier molecule additionally contains an amino acid component (AA)x′ wherein x is an integer selected from a range of about 1 to 100.3.The polymeric carrier molecule according to claim 2, wherein the amino acid component (AA)x comprises an aromatic amino acid component, a hydrophilic amino acid component, a lipophilic amino acid component, a weak basic amino acid component, a signal peptide, localization signal or sequence, a nuclear localization signal or sequence, a cell penetrating peptide, a therapeutically active protein or peptide, an antigen or an antigenic epitope, a tumour antigen, a pathogenic antigen (an animal antigen, a viral antigen, a protozoal antigen, a bacterial antigen, an allergic antigen), an autoimmune antigen, or a further antigen, an allergen, an antibody, an immunostimulatory protein or peptide, an antigenspecific T-cell receptor, or another protein or peptide suitable for a specific (therapeutic) application.", "4.The polymeric carrier molecule according to claim 1, wherein the amino acid component (AA)x occurs as a mixed repetitive amino acid component [(AA)x]z′ wherein z is an integer selected from a range of about 1 to 30.5.The polymeric carrier molecule according to claim 2, wherein formula (I) is modified according to formula (Ia) L-P1—S—{[S—P2—S]a[S-(AA)x-S]b}—S—P3-L, wherein x, z, S, L, AA, P1, P2 and P3 are as defined before and a+b=n, wherein n is as defined before, preferably in a range of about 1, 2, 3, 4, or 5 to 10; a is an integer, selected independent from integer b from a range of about 1 to 50, preferably in a range of about 1, 2, 3, 4, or 5 to 10, and b is an integer, selected independent from integer a from a range of about 1 to 50, preferably in a range of about 1, 2, 3, 4, or 5 to 10, and wherein the single components [S—P2—S] and [S-(AA)x-S] occur in any order in the subformula {[S—P2—S]a[S-(AA)x-S]b}.", "6.The polymeric carrier molecule according to claim 1, wherein component P2 is a cationic or polycationic peptide selected from protamine, nucleoline, spermine or spermidine, poly-L-lysine (PLL), basic polypeptides, polyarginine, cell penetrating peptides (CPPs), chimeric CPPs, Transportan, or MPG peptides, HIV-binding peptides, Tat, HIV-1 Tat (HIV), Tat-derived peptides, oligoarginines, members of the penetratin family, Penetratin, Antennapedia-derived peptides (particularly from Drosophila antennapedia), pAntp, plsl, etc., antimicrobial-derived CPPs, Buforin-2, Bac715-24, SynB, SynB(1), pVEC, hCT-derived peptides, SAP, MAP, KALA, PpTG20, Proline-rich peptides, Loligomere, Arginine-rich peptides, Calcitonin-peptides, FGF, Lactoferrin, histones, VP22 derived or analog peptides, HSV, VP22 (Herpes simplex), MAP, KALA or protein transduction domains (PTDs, PpT620, prolin-rich peptides, lysine-rich peptides, Pep-1, L-oligomers, Calcitonin peptide(s).", "7.The polymeric carrier molecule according to claim 1, wherein the —SH-moiety of component(s) P2 is provided by a cysteine.", "8.The polymeric carrier molecule according to claim 1, wherein component P2 is selected from a peptide comprising a cationic peptide of formula (IIb): Cys {(Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x}Cys, wherein l+m+n+o+x=8-15, and l, m, n or o independently of each other may be any number selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15, provided that the overall content of Arg, Lys, His and Orn represents at least 10% of all amino acids of the oligopeptide; and Xaa may be any amino acid selected from native or non-native amino acids except of Arg, Lys, His or Orn; and x may be any number selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14, provided, that the overall content of Xaa does not exceed 90% of all amino acids of the oligopeptide.", "9.Polymeric carrier cargo complex formed of a polymeric carrier molecule according to claim 1 and a nucleic acid.", "10.The polymeric carrier cargo complex according to claim 9, wherein the nucleic acid is provided in a molar ratio of about 5 to 10000 of inventive polymeric carrier molecule:nucleic acid.", "11.The polymeric carrier cargo complex according to claim 9, wherein the nucleic acid is a DNA or a RNA, a coding nucleic acid, a coding DNA, a coding RNA, a coding mRNA, an siRNA, an immunostimulatory nucleic acid, an immunostimulatory CpG nucleic acid, or an immunostimulatory RNA (isRNA), 12.The polymeric carrier cargo complex according to claim 9, wherein the nucleic acid encodes a therapeutically active protein or peptide, an antigen, including tumor antigens, pathogenic antigens, animal antigens, viral antigens, protozoal antigens, bacterial antigens, allergic antigens, autoimmune antigens, allergens, antibodies, immunostimulatory proteins or peptides, or antigen-specific T-cell receptors.", "13.Method of preparing a polymeric carrier molecule as defined in claim 1 comprising following steps a) providing at least one cationic or polycationic protein or peptide as component P2 as defined herein and/or at least one cationic or polycationic polymer as component P2 as defined according to claim 1, and optionally at least one further component (AA)x, mixing these components, preferably in a basic milieu, preferably in the presence of oxygen or a further starter which leads to mild oxidation conditions, and thereby condensing and thus polymerizing these components with each other via disulfide bonds in a polymerization condensation or polycondensation to obtain a repetitive component H—[S—P2—S]n—H or H{[S—P2—S]a[S-(AA)x-S]b}H; b) providing a hydrophilic polymer P1 and/or P3 as defined according to claim 1, optionally modified with a ligand L and/or an amino acid component (AA)x as defined according to claim 1; c) mixing the hydrophilic polymer P1 and/or P3 according to step b) with the repetitive component H—[S—P2—S]n—H or H{[S—P2—S]a[S-(AA)x-S]b}H obtained according to step a) in a ratio of about 2:1, and thereby typically terminating the polymerization condensation or polycondensation reaction and obtaining the inventive polymeric carrier molecule according to formula (I) or (Ia); d) optionally purifying the polymeric carrier molecule obtained according to step c).", "14.Pharmaceutical composition or vaccine, comprising the polymeric carrier cargo complex according to claim 9 and optionally a pharmaceutically acceptable carrier and/or vehicle.", "15.Polymeric carrier molecule according to claim 1 for use as a medicament.", "16.Polymeric carrier molecule according to claim 1, for use in the prophylaxis, treatment and/or amelioration of diseases selected from cancer or tumour diseases, infectious diseases, preferably (viral, bacterial or protozoological) infectious diseases, autoimmune diseases, allergies or allergic diseases, monogenetic diseases, i.e.", "(hereditary) diseases, or genetic diseases in general, diseases which have a genetic inherited background and which are typically caused by a defined gene defect and are inherited according to Mendel's laws, cardiovascular diseases, neuronal diseases, diseases of the respiratory system, diseases of the digestive system, diseases of the skin, musculoskeletal disorders, disorders of the connective tissue, neoplasms, immune deficiencies, endocrine, nutritional and metabolic diseases, eye diseases and ear diseases." ], [ "The present invention is directed to an inventive polymeric carrier molecule according to generic formula (I) and variations thereof, which allows for efficient transfection of nucleic acids into cells in vivo and in vitro, a polymeric carrier cargo complex formed by a nucleic acid and the inventive polymeric carrier molecule, but also to methods of preparation of this inventive polymeric carrier molecule and of the inventive polymeric carrier cargo complex.", "The present invention also provides methods of application and use of this inventive polymeric carrier molecule and the inventive polymeric carrier cargo complex as a medicament, for the treatment of various diseases, and in the preparation of a pharmaceutical composition for the treatment of such diseases.", "Various diseases today require a treatment which involves administration of peptide-, protein-, and nucleic acid-based drugs, particularly the transfection of nucleic acids into cells or tissues.", "The full therapeutic potential of peptide-, protein-, and nucleic acid-based drugs is frequently compromised by their limited ability to cross the plasma membrane of mammalian cells, resulting in poor cellular access and inadequate therapeutic efficacy.", "Today this hurdle represents a major challenge for the biomedical development and commercial success of many biopharmaceuticals (see e.g.", "Foerg and Merkle, Journal of Pharmaceutical Sciences, published online at www.interscience.wiley.com, 2008, 97(1): 144-62).", "For some diseases or disorders, gene therapeutic approaches have been developed as a specific form of such treatments.", "These treatments in general utilize transfection of nucleic acids or genes into cells or tissues, whereas gene therapeutic approaches additionally involve the insertion of one or more of these nucleic acids or genes into an individual's cells and tissues to treat a disease, e.g.", "hereditary diseases, in which a defective mutant allele is replaced with a functional one.", "Transfer or insertion of one or more of these nucleic acids or genes into an individual's cells, however, still represents a major challenge today and is absolutely necessary for ensuring a good therapeutical effect of a nucleic acid based medicaments, particularly in the field of gene therapy.", "To achieve successful transfer of nucleic acids or genes into an individual's cells, a number of different hurdles have to be passed.", "The transport of nucleic acids typically occurs via association of the nucleic acid with the cell membrane and subsequent uptake by the endosomes.", "In the endosomes, the introduced nucleic acids are separated from the cytosol.", "As expression occurs in the cytosol, these nucleic acids have to depart the cytosol.", "If the nucleic acids do not manage departing the cytosol, either the endosome fuses with the lysosome leading to a degradation of its content, or the endosome fuses with the cell membrane leading to a return of its content into the extracellular medium.", "For efficient transfer of nucleic acids, the endosomal escape thus appears to be one of the most important steps additional to the efficiency of transfection itself.", "Until now, there are different approaches addressing these issues.", "However, no approach was at least successful in all aspects.", "Transfection agents used in the art today typically comprise peptides, different polymers, lipids as well as nano- and microparticles (see e.g.", "Gao, X., K. S. Kim, et al.", "(2007), Aaps J 9(1): E92-104).", "These transfection agents typically have been used successfully only in in vitro reactions.", "When transfecting nucleic acids in vivo into cells of a living animal, further requirements have to be fulfilled.", "As an example, the complex has to be stable in physiological salt solutions with respect to agglomerisation.", "Furthermore, it does not interact with parts of the complement system of the host.", "Additionally, the complex shall protect the nucleic acid from early extracellular degradation by ubiquitiously occurring nucleases.", "For genetherapeutic applications it is furthermore of utmost importance, that the carrier is not recognized by the adaptive immune system (immunogenicity) and does not stimulate an unspecific cytokine storm (acute immune response) (see Gao, Kim et al., (2007, supra); Martin, M. E. and K. G. Rice (2007), Aaps J 9(1): E18-29; and Foerg and Merkle, (2008, supra)).", "Foerg and Merkle (2008, supra), discuss therapeutic potential of peptide-, protein and nucleic acid-based drugs.", "According to their analysis, the full therapeutic potential of these drugs is frequently compromised by their limited ability to cross the plasma membrane of mammalian cells, resulting in poor cellular access and inadequate therapeutic efficacy.", "Today this hurdle represents a major challenge for the biomedical development and commercial success of many biopharmaceuticals.", "In this context, Gao et al.", "(Gao et al.", "The AAPS Journal 2007; 9(1) Article 9) see the primary challenge for gene therapy in the development of a method that delivers a therapeutic gene to selected cells where proper gene expression can be achieved.", "Gene delivery and particularly successful transfection of nucleic acids into cells or tissue is, however, not simple and typically dependent on many factors.", "For successful delivery, e.g., delivery of nucleic acids or genes into cells or tissue, many barriers must be overcome.", "According to Gao et al.", "(2007) an ideal gene delivery method needs to meet 3 major criteria: (1) it should protect the transgene against degradation by nucleases in intercellular matrices, (2) it should bring the transgene across the plasma membrane and (3) it should have no detrimental effects.", "These goals may be achieved by using a combination of different compounds or vectors.", "Notably, there are some compounds or vectors, which overcome at least some of these barriers.", "Most usually, transfection, e.g.", "of nucleic acids, is carried out using viral or non-viral vectors.", "For successful delivery, these viral or non-viral vectors must be able to overcome the above mentioned barriers.", "The most successful gene therapy strategies available today rely on the use of viral vectors, such as adenoviruses, adeno-associated viruses, retroviruses, and herpes viruses.", "Viral vectors are able to mediate gene transfer with high efficiency and the possibility of long-term gene expression, and satisfy 2 out of 3 criteria.", "However, the acute immune response, immunogenicity, and insertion mutagenesis uncovered in gene therapy clinical trials have raised serious safety concerns about some commonly used viral vectors.", "A solution to this problem may be found in the use of non-viral vectors.", "Although non-viral vectors are not as efficient as viral vectors, many non-viral vectors have been developed to provide a safer alternative in gene therapy.", "Methods of nonviral gene delivery have been explored using physical (carrier-free gene delivery) and chemical approaches (synthetic vector-based gene delivery).", "Physical approaches usually include needle injection, electroporation, gene gun, ultrasound, and hydrodynamic delivery, employ a physical force that permeates the cell membrane and facilitates intracellular gene transfer.", "The chemical approaches typically use synthetic or naturally occurring compounds (cationic lipids, cationic polymers, lipid-polymer hybrid systems) as carriers to deliver the transgene into cells.", "Although significant progress has been made in the basic science and applications of various nonviral gene delivery systems, the majority of nonviral approaches is still much less efficient than viral vectors, especially for in vivo gene delivery (see e.g.", "Gao et al.", "The AAPS Journal 2007; 9(1) Article 9).", "Over the past decade, attractive prospects for a substantial improvement in the cellular delivery of nucleic acids have been announced that were supposed to result from their physical assembly or chemical ligation to so-called cell penetrating peptides (CPPs) also denoted as protein-transduction domains (PTDs) (see Foerg and Merkle, (2008, supra)).", "CPPs represent short peptide sequences of 10 to about 30 amino acids which can cross the plasma membrane of mammalian cells and may thus offer unprecedented opportunities for cellular drug delivery.", "Nearly all of these peptides comprise a series of cationic amino acids in combination with a sequence, which forms an α-helix at low pH.", "As the pH is continuously lowered in vivo by proton pumps, a conformational change of the peptide is usually initiated rapidly.", "This helix motif mediates an insertion into the membrane of the endosome leading to a release of its content into the cytoplasma (see Foerg and Merkle, (2008, supra); and Vives, E., P. Brodin, et a.", "(1997).", "“A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus.” J Biol Chem 272(25): 16010-7).", "Despite these advantages, a major obstacle to CPP mediated drug delivery is thought to consist in the often rapid metabolic clearance of the peptides when in contact or passing the enzymatic barriers of epithelia and endothelia.", "In conclusion, metabolic stability of CPPs represents an important biopharmaceutical factor for their cellular bioavailability.", "However, there are no CPPs available in the art, which are on the one hand side stable enough to carry their cargo to the target before they are metabolically cleaved, and which on the other hand side can be cleared from the tissue before they can accumulate and reach toxic levels.", "One further approach in the art for delivering cargo molecules into cells, e.g.", "for gene therapy, comprises peptide ligands (see Martin and Rice (see Martin and Rice, The AAPS Journal 2007; 9 (1) Article 3)).", "Peptide ligands can be short sequences taken from larger proteins that represent the essential amino acids needed for receptor recognition, such as EGF peptide used to target cancer cells.", "Other peptide ligands have been identified including the ligands used to target the lectin-like oxidized LDL receptor (LOX-1).", "Up-regulation of LOX-1 in endothelial cells is associated with dysfunctional states such as hypertension and atherosclerosis.", "Such peptide ligands, however, are not suitable for many gene therapeutic approaches, as they cannot be linked to their cargo molecules by complexation or adhesion but require covalent bonds, e.g.", "crosslinkers, which typically exhibit cytotoxic effects in the cell.", "Synthetic vectors may also be used in the art for delivering cargo molecules into cells, e.g., for the purpose of gene therapy.", "However, one main disadvantage of many synthetic vectors is their poor transfection efficiency compared to viral vectors and significant improvements are required to enable further clinical development.", "Several barriers that limit nucleic acid transfer both in vitro and in vivo have been identified, and include poor intracellular delivery, toxicity and instability of vectors in physiological conditions (see.", "e.g.", "Read, M. L., K. H. Bremner, et al.", "(2003).", "“Vectors based on reducible polycations facilitate intracellular release of nucleic acids.” J Gene Med 5(3): 232-45).", "One specific approach in gene therapy uses cationic lipids.", "However, although many cationic lipids show excellent transfection activity in cell culture, most do not perform well in the presence of serum, and only a few are active in vivo.", "A dramatic change in size, surface charge, and lipid composition occurs when lipoplexes are exposed to the overwhelming amount of negatively charged and often amphipatic proteins and polysaccharides that are present in blood, mucus epithelial lining fluid, or tissue matrix.", "Once administered in vivo, lipoplexes tend to interact with negatively charged blood components and form large aggregates that could be absorbed onto the surface of circulating red blood cells, trapped in a thick mucus layer or embolized in microvasculatures, preventing them from reaching the intended target cells in the distal location.", "Furthermore, toxicity related to gene transfer by lipoplexes has been observed.", "Symptomes include inter alia induction of inflammatory cyokines.", "In humans, various degrees of adverse inflammatory reactions, including flu-like symptoms were noted among subjects who received lipoplexes.", "Accordingly, it appears questionable, as to whether lipoplexes can be safely used in humans at all.", "One further, more promising approach in gene therapy utilizes cationic polymers.", "Cationic polymers turned out to be efficient in transfection of nucleic acids, as they can tightly complex and condense a negatively charged nucleic acid.", "Thus, a number of cationic polymers have been explored as carriers for in vitro and in vivo gene delivery.", "These include polyethylenimine (PEI), polyamidoamine and polypropylamine dendrimers, polyallylamine, cationic dextran, chitosan, cationic proteins and cationic peptides.", "Although most cationic polymers share the function of condensing DNA into small particles and facilitating cellular uptake via endocytosis through charge-charge interaction with anionic sites on cell surfaces, their transfection activity and toxicity differ dramatically.", "Interestingly, cationic polymers exhibit better transfection efficiency with rising molecular weight due to stronger complexation of the negatively charged nucleic acid cargo.", "However, a rising molecular weight also leads to a rising toxicity of the cationic polymer.", "PEI is perhaps the most active and most studied polymer for gene delivery, but its main drawback as a transfection reagent relates to its non-biodegradable nature and toxicity.", "Furthermore, even though polyplexes formed by high molecular weight polymers exhibit improved stability under physiological conditions, data have indicated that such polymers can hinder vector unpacking.", "For example, poly (L-lysine) (PLL) of 19 and 36 residues was shown to dissociate from DNA more rapidly than PLL of 180 residues resulting in significantly enhanced short-term gene expression.", "A minimum length of six to eight cationic amino acids is required to compact DNA into structures active in receptor-mediated gene delivery.", "However, polyplexes formed with short polycations are unstable under physiological conditions and typically aggregate rapidly in physiological salt solutions.", "To overcome this negative impact, Read et al.", "(see Read, M. L., K. H. Bremner, et al.", "(2003).", "“Vectors based on reducible polycations facilitate intracellular release of nucleic acids.” J Gene Med 5(3): 232-45; and Read, M. L., S. Singh, et al.", "(2005).", "“A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids.” Nucleic Acids Res 33(9): e86) developed a new type of synthetic vector based on a linear reducible polycation (RPC) prepared by oxidative polycondensation of the peptide Cys-Lys10-Cys that can be cleaved by the intracellular environment to facilitate release of nucleic acids.", "They could show that polyplexes formed by RPC are destabilised by reducing conditions enabling efficient release of DNA and mRNA.", "Cleavage of the RPC also reduced toxicity of the polycation to levels comparable with low molecular weight peptides.", "The disadvantage of this approach of Read et al.", "(2003, supra) was that the endosomolytic agent chloroquine or the cationic lipid DOTAP was additionally necessary to enhance transfection efficiency to adequate levels.", "As a consequence Read et al.", "(2005, supra) included histidine residues in the RPCs which have a known endosomal buffering capacity.", "They could show that histidine-rich RPCs can be cleaved by the intracellular reducing environment enabling efficient cytoplasmic delivery of a broad range of nucleic acids, including plasmid DNA, mRNA and siRNA molecules without the requirement for the endosomolytic agent chloroquine.", "Unfortunately; Read et al.", "(2005, supra) did not assess whether histidine-rich RPCs can be directly used for in vivo applications.", "In their study, transfections were performed in the absence of serum to avoid masking the ability of histidine residues to enhance gene transfer that may have arisen from binding of serum proteins to polyplexes restricting cellular uptake.", "Preliminary experiments indicate that the transfection properties of histidine-rich RPC polyplexes can be affected by the presence of serum proteins with a 50% decrease in GFP-positive cells observed in 10% FCS (fetal calf serum).", "For in vivo application they propose modifications with the hydrophilic polymer poly-[N-(2 hydroxy-propyl)methacrylamide].", "Unfortunately, Read et al.", "(2005, supra) did not prevent aggregation of polyplexes and binding of polycationic proteins to serum proteins.", "Furthermore, due to the large excess of polymer, which is characterized by the high N/P ratio, strong cationic complexes are formed when complexing the nucleic acid, which are only of limited use in vivo due to their strong tendency of salt induced agglomeration and interactions with serum contents (opsonization).", "Additionally, these complexes may excite an acute immune response, when used for purposes of gene therapy.", "Read et al (2003, supra) did also not provide in vivo data for the RPC based complexes shown in the publication.", "It has also turned out that these strong cationic RPC based complexes are completely inactive subsequent to local administration into the dermis.", "Furthermore Read et al.", "(2005, supra) used stringent oxidation conditions (30% DMSO) to induce the generation of high molecular polymers with as long as possible chain lengths (“step-growth polymerization”) to ensure complete complexation of the nucleic acid cargo.", "In an approach similar to Read et al.", "McKenzie et al.", "(McKenzie, D. L., K. Y. Kwok, et al.", "(2000), J Biol Chem 275(14): 9970-7., McKenzie, D. L., E. Smiley, et al.", "(2000), Bioconjug Chem 11(6): 901-9, and U.S. Pat.", "No.", "6,770,740 B1) developed self-crosslinking peptides as gene delivery agents by inserting multiple cysteines into short synthetic peptides for the purpose of decreasing toxicity as observed with high-molecular polycations.", "For complexation of DNA they mixed the self-crosslinking peptides with DNA to induce interpeptide disulfide bonds concurrently to complexation of the DNA cargo.", "For in vivo gene delivery approaches they propose the derivatization of the self-crosslinking peptides with a stealthing (e.g.", "polyethylene glycol) or targeting agent operatively attached to the peptide at a site distal from each terminus.", "In a further approach the same authors developed for the purpose of masking DNA peptide condensates and thereby reducing interaction with blood components, the derivatization of the non crosslinking cationic peptide CWK18 with polyethylene glycol by reducible or non-reducible linkages (Kwok, K. Y., D. L. McKenzie, et al.", "(1999).", "“Formulation of highly soluble poly(ethylene glycol)-peptide DNA condensates.” J Pharm Sci 88(10): 996-1003.).", "Summarizing the above, the present prior art as exemplified above suffers from various disadvantages.", "One particular disadvantage of the self-crosslinking peptides as described by Read et al.", "(2003, supra) or McKenzie et al.", "(2000 I and II, supra and U.S. Pat.", "No.", "6,770,740 B1) concerns the high positive charge on the surface of the particles formed.", "Due to the high positive charge the particles exhibit a high instability towards agglomeration when subjecting these particles in vivo to raised salt concentrations.", "Such salt concentrations, however, typically occur in vivo in cells or extracellular media.", "Furthermore, high positively charged complexes show a strong tendency of opsonization.", "This leads to an enhanced uptake by macrophages and furthermore to a fast inactivation of the complex due to degradation.", "Particularly the uptake of these complexes by cells of the immune system in general leads to a downstream stimulation of different cytokines.", "This unspecific activation of the innate immune system, however, represents a severe disadvantage of these systems and should be avoided, particularly for the purpose of several aspects of gene therapy, where an acute immune response (cytokine storm) is strictly to be avoided.", "Additionally, in biological systems positively charged complexes can easily be bound or immobilized by negatively charged components of the extracellular matrix or the serum.", "Also, the nucleic acids in the complex may be released too early, leading to reduced efficiency of the transfer and half life of the complexes in vivo.", "Furthermore, a reversible derivatization of carriers with a stealthing agent being advantageous for in vivo gene delivery, such as polyethylene glycol (PEG), was only possible for peptide monomers but not for self-crosslinking peptides or rather for a polymeric carrier with a defined polymer chain length.", "In particular, such a reversible derivatization was not possible at the terminal ends of the crosslinked cationic peptide carrier.", "Additionally, in the prior art only high-molecular polymers with long polymer chains or with an undefined polymer chain length consisting of self-crosslinking peptides were described, which unfortunately compact their cargo to such an extent that cargo release in the cell is limited.", "The extremely undefined polymer chain length is further problematic regarding approvement of a medicament based on RPC.", "One precondition for an approvement of a medicament is that every preparation of the medicament has always the same composition, the same structure and the same properties.", "This cannot be ensured for complexes based on RPC's from the prior art.", "Furthermore the RPC-based polymers or complexes provided in the prior art are difficult to characterize due to their undefined structure or polymer chain length.", "But characterization of the resulting complex or of the polymeric carrier is absolutely necessary for the approvement of a medicament.", "In consequence, no feasible method or carrier has been presented until today, which allows both compacting and stabilizing a nucleic acid for the purposes of gene therapy and other therapeutic applications, which show a good transfection activity in combination with a good release of the nucleic acid cargo, particularly in vivo and low or even no toxicity, e.g.", "due to the combination of a reversible stealthing and a reversible complexation of the nucleic acid by self-crosslinking polymers.", "Accordingly, there is still an intensive need in the art to provide carriers for the purpose of gene transfer, which are on the one hand side stable enough to carry their cargo to the target before they are metabolically cleaved, and which on the other hand side can be cleared from the tissue before they can accumulate and reach toxic levels.", "The object underlying the present invention is therefore to provide a carrier or a complexing agent, particularly for the transfection of nucleic acids for the purposes of gene therapy or other therapeutic applications, which is capable to compact nucleic acids, preferably coding DNA or coding RNA, such as mRNA, and which allows efficient transfection of the nucleic acid into different cell lines in vitro but also transfection in vivo.", "As uptake by cells occurs via the endosomal route, such a carrier or a complexing agent shall also allow or provide for efficient release of the nucleic acid.", "Additionally, it is preferred, that the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and such carrier or a complexing agent shows improved resistance to agglomeration.", "It should preferably also confer enhanced stability to the nucleic acid cargo with respect to serum containing media.", "Most importantly, in vivo activity shall be obtained, thereby suppressing at least in part an acute immune reaction.", "Furthermore a reproducible production and a characterization of the carrier should be assured.", "This object is solved by the subject matter of the present invention, preferably by the subject matter of the attached claims.", "Particularly, according to the first embodiment of the present invention the above object is solved by a polymeric carrier molecule according to generic formula (I): L-P1—S—[S—P2—S]n—S—P3-L wherein, P1 and P3 are different or identical to each other and represent a linear or branched hydrophilic polymer chain, each P1 and P3 exhibiting at least one —SH— moiety, capable to form a disulfide linkage upon condensation with component P2, or alternatively with (AA)x, or [(AA)x], if such components are used as a linker between P1 and P2 or P3 and P2) and/or with further components (e.g.", "(AA)x, [(AA)x]z or L), the linear or branched hydrophilic polymer chain selected independent from each other from polyethylene glycol (PEG), poly-N-(2-hydroxypropyl)methacrylamide, poly-2-(methacryloyloxy)ethyl phosphorylcholines, poly(hydroxyalkyl L-asparagine), poly(2-(methacryloyloxy)ethyl phosphorylcholine), hydroxyethylstarch or poly(hydroxyalkyl L-glutamine), wherein the hydrophilic polymer chain exhibits a molecular weight of about 1 kDa to about 100 kDa, preferably of about 2 kDa to about 25 kDa; or more preferably of about 2 kDa to about 10 kDa, e.g.", "about 5 kDa to about 25 kDa or 5 kDa to about 10 kDa; P2 is a cationic or polycationic peptide or protein, and preferably having a length of about 3 to about 100 amino acids, more preferably having a length of about 3 to about 50 amino acids, even more preferably having a length of about 3 to about 25 amino acids, e.g.", "a length of about 3 to 10, 5 to 15, 10 to 20 or 15 to 25 amino acids, more preferably a length of about 5 to about 20 and even more preferably a length of about 10 to about 20; is a cationic or polycationic polymer, typically having a molecular weight of about 0.5 kDa to about 30 kDa, including a molecular weight of about 1 kDa to about 20 kDa, even more preferably of about 1.5 kDa to about 10 kDa, or having a molecular weight of about 0.5 kDa to about 100 kDa, including a molecular weight of about 10 kDa to about 50 kDa, even more preferably of about 10 kDa to about 30 kDa; each P2 exhibiting at least two —SH-moieties, capable to form a disulfide linkage upon condensation with further components P2 or component(s) P1 and/or P3 or alternatively with further components (e.g.", "(AA)x, or [(AA)x]z) —S—S— is a (reversible) disulfide bond (the brackets are omitted for better readability), wherein S preferably represents sulphur or a —SH carrying moiety, which has formed a (reversible) disulfide bond.", "The (reversible) disulfide bond is preferably formed by condensation of —SH-moieties of either components P1 and P2, P2 and P2, or P2 and P3, or optionally of further components as defined herein (e.g.", "L, (AA)x, [(AA)x]z, etc.", "); The —SH-moiety may be part of the structure of these components or added by a modification as defined below; L is an optional ligand, which may be present or not, and may be selected independent from the other from RGD, Transferrin, Folate, a signal peptide or signal sequence, a localization signal or sequence, a nuclear localization signal or sequence (NLS), an antibody, a cell penetrating peptide, (e.g.", "TAT or KALA), a ligand of a receptor (e.g.", "cytokines, hormones, growth factors etc.", "), small molecules (e.g.", "carbohydrates like mannose or galctose or synthetic ligands), small molecule agonists, inhibitors or antagonists of receptors (e.g.", "RGD peptidomimetic analogues) etc.", "; n is an integer, typically selected from a range of about 1 to 50, preferably from a range of about 1, 2 or 3 to 30, more preferably from a range of about 1, 2, 3, 4, or 5 to 25, or a range of about 1, 2, 3, 4, or 5 to 20, or a range of about 1, 2, 3, 4, or 5 to 15, or a range of about 1, 2, 3, 4, or 5 to 10, including e.g.", "a range of about 4 to 9, 4 to 10, 3 to 20, 4 to 20, 5 to 20, or 10 to 20, or a range of about 3 to 15, 4 to 15, 5 to 15, or 10 to 15, or a range of about 6 to 11 or 7 to 10.Most preferably, n is in a range of about 1, 2, 3, 4, or 5 to 10, more preferably in a range of about 1, 2, 3, or 4 to 9, in a range of about 1, 2, 3, or 4 to 8, or in a range of about 1, 2, or 3 to 7.The inventive polymeric carrier molecule according to generic formula (I) is prepared by a new synthesis strategy and advantageously allows to define the length of the polymer chain and to combine desired properties of different (short) polymers in one polymer, e.g.", "to efficiently compact nucleic acids for the purpose of efficient transfection of nucleic acids for the purposes of gene therapy or other therapeutic applications without loss of activity, particularly efficient transfection of a nucleic acid into different cell lines in vitro but also transfection in vivo.", "The inventive polymeric carrier molecule is furthermore not toxic to cells and provides for efficient release of its nucleic acid cargo.", "Finally, it shows improved resistance to agglomeration due to the reversible addition of hydrophilic polymer chains (e.g.", "PEG-monomers) particularly to the terminal ends of the inventive polymeric carrier molecule according to generic formula (I), which additionally confers enhanced stability of the nucleic acid cargo with respect to serum containing media and prevents recognition of the polymeric carrier cargo complex by the immune system.", "Even more advantageously, the inventive polymeric carrier molecule according to generic formula (I) allows to considerably vary its peptide or polymeric content and thus to modulate its biophysical/biochemical properties, particularly the cationic properties of component [S—P2—S]n, quite easily and fast, e.g.", "by incorporating as components P2 the same or different cationic peptide(s), protein(s) or polymer(s) and optionally adding other components, e.g.", "amino acid component(s) (AA)x, into the repetitive component [S—P2—S] to form a modified repetitive component such as {[S—P2—S]a/[S-(AA)x-S]b} as a core motif of the inventive polymeric carrier (wherein a+b=n, see below).", "Even though consisting of quite small non-toxic monomer units the inventive polymeric carrier molecule forms a cationic binding sequence with a defined chain length providing a strong condensation of the nucleic acid cargo and complex stability.", "Under the reducing conditions of the cytosole (e.g.", "cytosolic GSH), the complex is rapidly degraded into its monomers, which are further degraded (e.g.", "oligopeptides) or secreted (e.g.", "PEG).", "This supports deliberation of the nucleic acid cargo in the cytosol.", "Due to degradation into small oligopeptides in the cytosole, no toxicity is observed as known for high-molecular oligopeptides, e.g.", "from high-molecular oligoarginine.", "The PEG-“coating” also allows to somehow “coat” the polymeric carrier with a hydrophilic coating at its terminal ends, which prevents salt-mediated agglomeration and undesired interactions with serum contents.", "In the cytosole, this “coating” is easily removed under the reducing conditions of the cell.", "Also, this effect promotes deliberation of the nucleic acid cargo in the cytosol.", "As defined above, ligands (L), may be optionally used in the inventive polymeric carrier molecule according to generic formula (I), e.g.", "for direction of the inventive carrier polymer and its complexed nucleic acid into specific cells.", "They may be selected independent from the other from RGD, Transferrin, Folate, a signal peptide or signal sequence, a localization signal or sequence, a nuclear localization signal or sequence (NLS), an antibody, a cell penetrating peptide, (e.g.", "TAT), a ligand of a receptor (e.g.", "cytokines, hormones, growth factors etc.", "), small molecules (e.g.", "carbohydrates like mannose or galctose or synthetic ligands), small molecule agonists, inhibitors or antagonists of receptors (e.g.", "RGD peptidomimetic analogues) etc.", "Particularly preferred in this context is mannose as ligand to target antigen presenting cells which carries on their cell membrane mannose receptors.", "In a further preferred aspect of the first embodiment of the present invention galactose as optional ligand can be used to target hepatocytes.", "Such ligands may be attached to component P1 and/or P3 by reversible disulfide bonds as defined below or by any other possible chemical attachment, e.g.", "by amide formation (e.g.", "carboxylic acids, sulphonic acids, amines, etc.", "), by Michael addition (e.g maleinimide moieties, α,β unsatured carbonyls, etc.", "), by click chemistry (e.g.", "azides or alkines), by alkene/alkine methatesis (e.g.", "alkenes or alkines), imine or hydrozone formation (aldehydes or ketons, hydrazins, hydroxylamins, amines), complexation reactions (avidin, biotin, protein G) or components which allow Sn-type substitution reactions (e.g halogenalkans, thiols, alcohols, amines, hydrazines, hydrazides, sulphonic acid esters, oxyphosphonium salts) or other chemical moieties which can be utilized in the attachment of further components.", "In the context of formula (I) of the present invention components P1 and P3 represent a linear or branched hydrophilic polymer chain, containing at least one —SH-moiety, each P1 and P3 independently selected from each other, e.g.", "from polyethylene glycol (PEG), poly-N-(2-hydroxypropyl)methacrylamide, poly-2-(methacryloyloxy)ethyl phosphorylcholines, poly(hydroxyalkyl L-asparagine) or poly(hydroxyalkyl L-glutamine).", "P1 and P3 may be identical or different to each other.", "Preferably, each of hydrophilic polymers P1 and P3 exhibits a molecular weight of about 1 kDa to about 100 kDa, preferably of about 1 kDa to about 75 kDa, more preferably of about 5 kDa to about 50 kDa, even more preferably of about 5 kDa to about 25 kDa.", "Additionally, each of hydrophilic polymers P1 and P3 typically exhibits at least one —SH-moiety, wherein the at least one —SH-moiety is capable to form a disulfide linkage upon condensation with component P2 or with component (AA)x, if used as linker between P1 and P2 or P3 and P2 as defined below and optionally with a further component, e.g.", "L and/or (AA)x, e.g.", "if two or more —SH-moieties are contained.", "The following subformulas “P1—S—S—P2” and “P2—S—S—P3” of generic formula (I) above (the brackets are omitted for better readability), wherein any of S, P1 and P3 are as defined herein, typically represent a situation, wherein one-SH-moiety of hydrophilic polymers P1 and P3 was condensed with one —SH-moiety of component P2 of generic formula (I) above, wherein both sulphurs of these —SH-moieties form a disulfide bond —S—S— as defined herein in formula (I).", "These —SH-moieties are typically provided by each of the hydrophilic polymers P1 and P3, e.g.", "via an internal cysteine or any further (modified) amino acid or compound which carries a —SH moiety.", "Accordingly, the subformulas “P1—S—S—P2” and “P2—S—S—P3” may also be written as “P1-Cys-Cys-P2” and “P2-Cys-Cys-P3”, if the —SH— moiety is provided by a cysteine, wherein the term Cys-Cys represents two cysteines coupled via a disulfide bond, not via a peptide bond.", "In this case, the term “—S—S—” in these formulae may also be written as “—S-Cys”, as “-Cys-S” or as “-Cys-Cys-”.", "In this context, the term “-Cys-Cys-” does not represent a peptide bond but a linkage of two cysteines via their —SH-moieties to form a disulfide bond.", "Accordingly, the term “-Cys-Cys-” also may be understood generally as “-(Cys-S)—(S-Cys)-”, wherein in this specific case S indicates the sulfur of the —SH-moiety of cysteine.", "Likewise, the terms “—S-Cys” and “-Cys-S” indicate a disulfide bond between a —SH containing moiety and a cysteine, which may also be written as “—S—(S-Cys)” and “-(Cys-S)—S”.", "Alternatively, the hydrophilic polymers P1 and P3 may be modified with a —SH moiety, preferably via a chemical reaction with a compound carrying a —SH moiety, such that each of the hydrophilic polymers P1 and P3 carries at least one such —SH moiety.", "Such a compound carrying a —SH moiety may be e.g.", "an (additional) cysteine or any further (modified) amino acid, which carries a —SH moiety.", "Such a compound may also be any non-amino compound or moiety, which contains or allows to introduce a —SH moiety into hydrophilic polymers P1 and P3 as defined herein.", "Such non-amino compounds may be attached to the hydrophilic polymers P1 and P3 of formula (I) according to the present invention via chemical reactions or binding of compounds, e.g.", "by binding of a 3-thio propionic acid or thioimolane, by amide formation (e.g.", "carboxylic acids, sulphonic acids, amines, etc.", "), by Michael addition (e.g maleinimide moieties, α,β unsatured carbonyls, etc.", "), by click chemistry (e.g.", "azides or alkines), by alkene/alkine methatesis (e.g.", "alkenes or alkines), imine or hydrozone formation (aldehydes or ketons, hydrazins, hydroxylamins, amines), complexation reactions (avidin, biotin, protein G) or components which allow Sn-type substitution reactions (e.g halogenalkans, thiols, alcohols, amines, hydrazines, hydrazides, sulphonic acid esters, oxyphosphonium salts) or other chemical moieties which can be utilized in the attachment of further components.", "A particularly preferred PEG derivate in this context is alpha-Methoxy-omega-mercapto poly(ethylene glycol).", "In each case, the SH-moiety, e.g.", "of a cysteine or of any further (modified) amino acid or compound, may be present at the terminal ends or internally at any position of hydrophilic polymers P1 and P3.As defined herein, each of hydrophilic polymers P1 and P3 typically exhibits at least one —SH-moiety preferably at one terminal end, but may also contain two or even more —SH-moieties, which may be used to additionally attach further components as defined herein, e.g.", "a ligand, an amino acid component (AA)x, antibodies, cell penetrating peptides (e.g.", "TAT), etc.", "According to a further preferred aspect of the first embodiment of the present invention, each of hydrophilic polymers P1 and P3 may also contain at least one further functional moiety, which allows attaching further components as defined herein, e.g.", "a ligand, an amino acid component (AA)x, etc.", "Such functional moieties may be selected from functionalities which allow the attachment of further components, e.g.", "functionalities as defined herein, e.g.", "by amide formation (e.g.", "carboxylic acids, sulphonic acids, amines, etc.", "), by Michael addition (e.g maleinimide moieties, α,β unsatured carbonyls, etc.", "), by click chemistry (e.g.", "azides or alkines), by alkene/alkine methatesis (e.g.", "alkenes or alkines), imine or hydrozone formation (aldehydes or ketons, hydrazins, hydroxylamins, amines), complexation reactions (avidin, biotin, protein G) or components which allow Sn-type substitution reactions (e.g halogenalkans, thiols, alcohols, amines, hydrazines, hydrazides, sulphonic acid esters, oxyphosphonium salts) or other chemical moieties which can be utilized in the attachment of further components.", "Component P2 in the context of formula (I) of the present invention preferably represents a cationic or polycationic peptide or protein or alternatively a cationic or polycationic polymer.", "Each component P2 typically exhibits at least two —SH-moieties, capable to form a disulfide linkage upon condensation with further components P2, component(s) P1 and/or P3 or alternatively with further components, e.g.", "amino acid components (AA)x.", "Component P2 typically occurs within the repetitive component [—S—P2—S—], of formula (I) of the present invention.", "The term “cationic or polycationic” typically refers to a charged molecule, which is positively charged (cation) at a pH value of about 1 to 9, preferably 4 to 9, 5 to 8 or even 6 to 8, more preferably of a pH value of or below 9, of or below 8, of or below 7, most preferably at physiological pH values, e.g.", "about 7.3 to 7.4.Accordingly, a cationic or polycationic peptide or protein as component P2 or alternatively a cationic or polycationic polymer as component P2 according to the present invention is positively charged under physiological conditions, particularly under physiological salt conditions of the cell in vivo.", "In the specific case that component P2 of formula (I) of the present invention is a cationic or polycationic peptide or protein the cationic properties of component [S—P2—S]n or {[S—P2—S]a/[S-(AA)x-S]b (as defined below) may be determined upon its content of cationic amino acids in the entire component [S—P2—S]n or {[S—P2—S]a/[S-(AA)x-S]b}.", "Preferably, the content of cationic amino acids in component [S—P2—S]n or {[S—P2—S]a/[S-(AA)x-S]b} is at least 10%, 20%, or 30%, preferably at least 40%, more preferably at least 50%, 60% or 70%, but also preferably at least 80%, 90%, or even 95%, 96%, 97%, 98%, 99% or 100%, most preferably at least 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99% or 100%, or may be in the range of about 10% to 90%, more preferably in the range of about 15% to 75%, even more preferably in the range of about 20% to 50%, e.g.", "20, 30, 40 or 50%, or in a range formed by any two of the afore mentioned values, provided, that the content of all amino acids, e.g.", "cationic, lipophilic, hydrophilic, aromatic and further amino acids, in the entire component [S—P2—S]n or {[S—P2—S]a/[S-(AA)x-S]b} is 100%.", "In the specific case that component P2 of formula (I) of the present invention is a cationic or polycationic polymer the cationic properties of component [S—P2—S]n or {[S—P2—S]a/[S-(AA)x-S]b} may be determined upon its content of cationic charges in the entire component [S—P2—S]n or {[S—P2—S]a/[S-(AA)x-S]b} when compared to the overall charges of component [S—P2—S]n or {[S—P2—S]a/[S-(AA)x-S]b}.", "Preferably, the content of cationic charges in component [S—P2—S]n or {[S—P2-s]a[S-(AA)x-S]b} at a (physiological) pH as defined herein is at least 10%, 20%, or 30%, preferably at least 40%, more preferably at least 50%, 60% or 70%, but also preferably at least 80%, 90%, or even 95%, 96%, 97%, 98%, 99% or 100%, most preferably at least 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99% or 100%, or may be in the range of about 10% to 90%, more preferably in the range of about 15% to 75%, even preferably in the range of about 20% to 50%, e.g.", "20, 30, 40 or 50%, or in a range formed by any two of the afore mentioned values, provided, that the content of all charges, e.g.", "positive and negative charges at a (physiological) pH as defined herein, in the entire component [S—P2—S]n or {[S—P2—S]a/[S-(AA)x-S]b} is 100%.", "In the specific context of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) L-P1—S—[S—P2—S]n—S—P3-L as defined herein (or according to any of its subformulas herein) it is particularly preferred that at least 10% of all charges in the whole repetitive component [S—P2—S]n or {[S—P2—S]a/[S-(AA)x-S]b} are cationic to allow complexation of the negatively charged nucleic acid cargo.", "The cationic or polycationic peptide or protein as component P2, or the cationic or polycationic polymer as component P2, is preferably a linear molecule, however, branched cationic or polycationic peptides or proteins as component P2 or branched cationic or polycationic polymers as component P2 may also be used.", "Typically, component P2, e.g.", "the cationic or polycationic peptide or protein or the cationic or polycationic polymer as defined herein, is linked to its neighboring components, e.g.", "components P1 and P3, and/or as a part of repetitive component [S—P2—S]n to further components P2, via disulfide bonds (—S—S—) or to (AA)x components as part of {[S—P2—S]a/[S-(AA)x-S]b}.", "In this context, the sulfurs adjacent to component P2 in the repetitive component [S—P2—S]n and as defined in generic formula (I) L-P1—S—[S—P2—S]n—S—P3-L, necessary for providing a disulfide bond, may be provided by component P2 itself by a —SH moiety as defined herein or may be provided by modifying component P2 accordingly to exhibit a —SH moiety within the above definition of repetitive component [S—P2—S]n. The —SH moieties for component P2 are preferably as defined herein for components P1 and P3.If such —SH-moieties, necessary to form a disulfide bond (—S—S—) within the above meaning, are provided by component P2 itself this may occur e.g.", "by at least two cysteines or any further (modified) amino acids or chemical compounds, which carry a —SH moiety, already occurring within the amino acid sequence of component P2 at whatever position of the amino acid sequence of component P2.Alternatively, component P2 may be modified accordingly with a chemical compound, e.g.", "a cysteine or any further (modified) amino acid or chemical compound, which carries a (free) —SH moiety.", "Thereby, component P2 preferably carries at least two —SH-moieties, which sulphurs atoms are capable to form a disulfide bond upon condensation with a-SH-moiety of components P1 or P3 as defined herein, or between a first component P2 and a further component P2, etc.", "Such —SH-moieties are preferably as defined herein.", "Preferably the at least two SH-moieties are located at the terminal ends or near to the terminal ends of component P2 According to one specific aspect of the first embodiment of the present invention, component P2 within repetitive component [S—P2—S]n of generic formula (I) above may comprise a cysteine as a —SH moiety.", "In this context, repetitive component [S—P2—S]n may thus be written as follows: [Cys-P2-Cys] wherein n and P2 are as defined herein and each Cys provides for the —SH-moiety for the disulfide bond.", "Cys is the amino acid cysteine in its three letter code.", "(For illustrative purposes, in the present description the disulfide bond —S—S— generally may also be written as -(Cys-S)—(S-Cys)-, wherein Cys-S represents a Cysteine with an naturally occurring —SH moiety, wherein this —SH moiety forms a disulfide bond with a —SH moiety of a second cysteine.", "Accordingly, repetitive component [Cys-P2-Cys]n may also be written as [(S-Cys)-P2-(Cys-S)]n, which indicates that the —SH-moiety is provided by a cysteine and the Cysteine itself provides for the sulfur of the disulfide bond.)", "In the context of the entire formula (I) above, this specific aspect of the first embodiment thus may be defined as follows: L-P1—S-[Cys-P2-Cys]n-S—P3-L wherein L, P1, P2, P3 and n are as defined herein, S is sulphur and each Cys provides for one —SH-moiety for the disulfide bond.", "In each case, the SH-moiety, e.g.", "of a cysteine or any further (modified) amino acid or further compound used for modification of component P2, may be present in the cationic or polycationic peptide or protein or cationic or polycationic polymer as component P2, internally or at one or both of its terminal ends, e.g.", "if a cationic or polycationic peptide or protein is used as component P2 at the N-terminal end or at the C-terminal end, at both these terminal ends, and/or internally at any position of the cationic or polycationic peptide or protein as component P2.Preferably, the —SH moiety may be present in component P2 at least at one terminal end, more preferably at both terminal ends, e.g.", "at the N-terminal end and/or at the C-terminal end, more preferably at both the N-terminal and the C-terminal end of a cationic or polycationic peptide or protein as component P2.Due to its repetitive character component [S—P2—S]n may represent a situation, wherein one of the at least two —SH-moieties of component P2 was condensed with a —SH-moiety of a further component P2 of generic formula (I) above, wherein both sulphurs of these —SH-moieties form a disulfide bond (—S—S—) between a first component P2 and at least one further component P2.In this context, the number of repetitions of component P2 in formula (I) according to the present invention is defined by integer n. n is an integer, typically selected from a range of about 1 to 50, preferably from a range of about 1, 2 or 3 to 30, more preferably from a range of about 1, 2, 3, 4, or 5 to 25, or a range of about 1, 2, 3, 4, or 5 to 20, or a range of about 1, 2, 3, 4, or 5 to 15, or a range of about 1, 2, 3, 4, or 5 to 10, including e.g.", "a range of about 3 to 20, 4 to 20, 5 to 20, or 10 to 20, or a range of about 3 to 15, 4 to 15, 5 to 15, or 10 to 15, or a range of about 6 to 11 or 7 to 10.If, for example, in repetitive component [S—P2—S]n integer n is 5, repetitive component [S—P2—S]n preferably reads as follows: [S—P2—S—S—P2—S—S—P2—S—S—P2—S—S—P2—S] In the above example component P2 occurs 5 times (preferably in a linear order), wherein each component P2 is linked to its neighbor component by a disulfide bond within the above definition of repetitive component [S—P2—S]n. Any of components P2 may be the same or different from each other.", "According to one particular aspect of this embodiment, component P2 represents a cationic or polycationic peptide or protein having a length of about 3 to about 100 amino acids, more preferably having a length of about 3 to about 50 amino acids, even more preferably having a length of about 3 to about 25 amino acids, e.g.", "having a length of about 3 to 10, 5 to 15, 10 to 20 or 15 to 25 amino acids, more preferably a length of about 5 to about 20 and even more preferably a length of about 10 to about 20.The cationic or polycationic peptide or protein as component P2 may be any protein or peptide suitable for this purpose and exhibiting at least two —SH-moieties, particular any cationic or polycationic peptide or protein capable to complex a nucleic acid as defined according to the present invention, and thereby preferably condensing the nucleic acid.", "Particularly preferred, cationic or polycationic peptides or proteins as component P2 exhibiting at least two —SH-moieties may be selected from protamine, nucleoline, spermine or spermidine, poly-L-lysine (PLL), basic polypeptides, poly-arginine, cell penetrating peptides (CPPs), chimeric CPPs, such as Transportan, or MPG peptides, HIV-binding peptides, Tat, HIV-1 Tat (HIV), Tat-derived peptides, oligoarginines, members of the penetratin family, e.g.", "Penetratin, Antennapedia-derived peptides (particularly from Drosophila antennapedia), pAntp, pIsI, etc., antimicrobial-derived CPPs e.g.", "Buforin-2, Bac715-24, SynB, SynB(1), pVEC, hCT-derived peptides, SAP, MAP, KALA, PpTG20, Proline-rich peptides, Loligomere, Arginine-rich peptides, Calcitonin-peptides, FGF, Lactoferrin, histones, VP22 derived or analog peptides, HSV, VP22 (Herpes simplex), MAP, KALA or protein transduction domains (PTDs, PpT620, prolin-rich peptides, lysine-rich peptides, Pep-1, L-oligomers, Calcitonin peptide(s), etc.", "According to one particular preferred aspect of the first embodiment of the present invention, cationic or polycationic peptides or proteins as component P2 are selected from following cationic peptides having the following total sum formula (II), preferably under the provison that they exhibit additionally at least two —SH-moieties: {(Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x}; (formula (II)) wherein l+m+n+o+x=8-15, and l, m, n or o independently of each other may be any number selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15, provided that the overall content of Arg, Lys, His and Orn represents at least 10% of all amino acids of the oligopeptide; and Xaa may be any amino acid selected from native (=naturally occurring) or non-native amino acids except of Arg, Lys, His or Orn; and x may be any number selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14, provided, that the overall content of Xaa does not exceed 90% of all amino acids of the oligopeptide.", "Any of amino acids Arg, Lys, His, Orn and Xaa may be positioned at any place of the peptide.", "Particularly preferred peptides of this formula are oligoarginines such as e.g.", "Arg7, Arg8, Arg9, Arg7, H3R9, R9H3, H3R9H3, YSSR9SSY, (RKH)4, Y(RKH)2R, etc.", "(SEQ ID NOs: 1-9).", "According to a particular preferred aspect of the first embodiment, cationic or polycationic peptides or proteins as component P2, having the empirical formula (II) as shown above and additionally exhibiting at least two —SH-moieties, may be, without being restricted thereto, selected from the following subgroup of formulae: Arg8, Arg9, Arg10, Arg11, Arg12, Arg13, Arg14, Arg15; (SEQ ID NOs: 2-3, 10-15); Lys8, Lys9, Lys10, Lys11, Lys12, Lys73, Lys14, Lys15; (SEQ ID NOs: 16-23); His8, His9, His10, His11, His12, His13, His14, His15; (SEQ ID NOs: 24-31); Orn8, Orn9, Orn10, Orn11, Orn12, Orn13, Orn14, Orn15; (SEQ ID NOs: 32-39); According to a further particularly preferred aspect of the first embodiment, cationic or polycationic peptides or proteins as component P2, having the empirical formula (II) as shown above and additionally exhibiting at least two —SH-moieties, may be, without being restricted thereto, selected from the following subgroup of formulae, wherein the following formulae (as with empirical formula (II)) do not specify any amino acid order, but are intended to reflect empirical formulae by exclusively specifying the (number of) amino acids as components of the respective peptide.", "Accordingly, as an example, empirical formula Arg(7-14)Lys1 is intended to mean that peptides falling under this formula contain 7 to 14 Arg residues and 1 Lys residue of whatsoever order.", "If the peptides contain 7 Arg residues and 1 Lys residue, all variants having 7 Arg residues and 1 Lys residue are encompassed.", "The Lys residue may therefore be positioned anywhere in the e.g.", "8 amino acid long sequence composed of 7 Arg and 1 Lys residues.", "The subgroup preferably comprises: Arg(7-14)Lys1, Arg(7-14)His1, Arg(7-14)Orn1, Lys(7-14)His1, Lys(7-14)Orn1, His(7-14)Orn1; Arg(6-13)Lys2, Arg(6-13)His2, Arg(6-13)Orn2, Lys(6-13)His2, Lys(6-13)Orn2, His(6-13)Orn2; Arg(5-12)Lys3, Arg(5-12)His3, Arg(5-12)Orn3, Lys(5-12)His3, Lys(5-12)Orn3, His(5-12)Orn3; Arg(4-11)Lys4, Arg(4-11)His4, Arg(4-11)Orn4, Lys(4-11)His4, Lys(4-11)Orn4, His(4-11)Orn4; Arg(3-10)Lys5, Arg(3-10)His5, Arg(3-10)Orn5, Lys(3-10)His5, Lys(3-10)Orn5, His(3-10)Orn5; Arg(2-9)Lys6, Arg(2-9)His6, Arg(2-9)Orn6, Lys(2-9)His6, Lys(2-9)Orn6, His(2-9)Orn6; Arg(1-8)Lys7, Arg(1-8)His7, Arg(1-8)Orn7, Lys(1-8)His7, Lys(1-8)Orn7, His(1-8)Orn7; Arg(6-13)Lys1His1, Arg(6-13)Lys1Orn1, Arg(6-13)His1Orn1, Arg1Lys(6-13)His1, Arg1Lys(6-13)Orn1, Lys(6-13) His1Orn1, Arg1Lys1His(6-13), Arg1His(6-13)Orn1, Lys1His(6-13)Orn1; Arg(5-12)Lys2His1, Arg(5-12)Lys1His2, Arg(5-12)Lys2Orn1, Arg(5-12)Lys1Orn2, Arg(5-12)His2Orn1, Arg(5-12) His1Orn2, Arg2Lys(5-12)His2, Arg2Lys(5-12)His2, Arg2Lys(5-12)Orn1, Arg2Lys(5-12)Orn2, Lys(5-12) His2Orn1, Lys(5-12)His1Orn2, Arg2Lys2His(5-12), Arg1Lys2His(5-12), Arg2His(5-12)Orn1, Arg1His(5-12) Orn2, Lys2His(5-12)Orn1, Lys1His(5-12)Orn2; Arg(4-11)Lys3His1, Arg(4-11)Lys2His2, Arg(4-11)Lys1His3, Arg(4-11)Lys3Orn1, Arg(4-11)Lys2Orn2, Arg(4-11) Lys1Orn3, Arg(4-11)His3Orn1, Arg(4-11)His2Orn2, Arg(4-11)His1Orn3, Arg3Lys(4-11)His1, Arg2Lys(4-11) His2, Arg1Lys(4-11)His3, Arg3Lys(4-11)Orn1, Arg2Lys(4-11)Orn2, Arg1Lys(4-11)Orn3, Lys(4-11)His3Orn1, Lys(4-11)His2Orn2, Lys(4-11)His1Orn3, Arg3Lys1His(4-11), Arg2Lys2His(4-11), Arg1Lys3His(4-11), Arg3His(4-11)Orn1, Arg2His(4-11)Orn2, Arg1His(4-11)Orn3, Lys3His(4-11)Orn1, Lys2His(4-11)Orn2, Lys1His(4-11)Orn3; Arg(3-10)Lys4His1, Arg(3-10)Lys3His2, Arg(3-10)Lys2His3, Arg(3-10)Lys1His4, Arg(3-10)Lys4Orn1, Arg(3-10) Lys3Orn2, Arg(3-10)Lys2Orn3, Arg(3-10)Lys1Orn4, Arg(3-10)His4Orn1, Arg(3-10)His3Orn2, Arg(3-10) His2Orn3, Arg(3-10)His1Orn4, Arg4Lys(3-10)His1, Arg3Lys(3-10)His2, Arg2Lys(3-10)His3, Arg1Lys(3-10) His4, Arg4Lys(3-10)Orn1, Arg3Lys(3-10)Orn2, Arg2Lys(3-10)Orn3, Arg1Lys(3-10)Orn4, Lys(3-10)His4Orn1, Lys(3-10)His3Orn2, Lys(3-10)His2Orn3, Lys(3-10)His1Orn4, Arg4Lys1His(3-10), Arg3Lys2His(3-10), Arg2Lys3His(3-10), Arg2Lys4His(3-10), Arg4His(3-10)Orn1, Arg3His(3-10)Orn2, Arg2His(3-10)Orn3, Arg1His(3-10)Orn4, Lys4His(3-10)Orn1, Lys3His(3-10)Orn2, Lys2His(3-10)Orn3, Lys1His(3-10)Orn4; Arg(2-9)Lys5His1, Arg(2-9)Lys4His2, Arg(2-9)Lys3His3, Arg(2-9)Lys2His4, Arg(2-9)Lys1His5, Arg(2-9) Lys5Orn1, Arg(2-9)Lys4Orn2, Arg(2-9)Lys3Orn3, Arg(2-9)Lys2Orn4, Arg(2-9)Lys1Orn5, Arg(2-9)His5Orn1, Arg(2-9)His4Orn2, Arg(2-9)His3Orn3, Arg(2-9)His2Orn4, Arg(2-9)His1Orn5, Arg5Lys(2-9)His1, Arg4Lys(2-9) His2, Arg3Lys(2-9)His3, Arg2Lys(2-9)His4, Arg1Lys(2-9)His5, Arg5Lys(2-9)Orn1, Arg4Lys(2-9)Orn2, Arg3Lys(2-9)Orn3, Arg2Lys(2-9)Orn4, Arg1Lys(2-9)Orn5, Lys(2-9)His5Orn1, Lys(2-9)His4Orn2, Lys(2-9) His3Orn3, Lys(2-9)His2Orn4, Lys(2-9)His1Orn5, Arg5Lys1His(2-9), Arg4Lys2His(2-9), Arg3Lys3His(2-9), Arg2Lys4His(2-9), Arg1Lys5His(2-9), Arg5His(2-9)Orn1, Arg4His(2-9)Orn2, Arg3His(2-9)Orn3, Arg2His(2-9) Orn4, Arg1His(2-9)Orn5, Lys5His(2-9)Orn1, Lys4His(2-9)Orn2, Lys3His(2-9)Orn3, Lys2His(2-9)Orn4, Lys1His(2-9)Orn5; Arg(1-8)Lys6His1, Arg(1-8)Lys5His2, Arg(1-8)Lys4His3, Arg(1-8)Lys3His4, Arg(1-8)Lys2His5, Arg(1-8) Lys1His6, Arg(1-8)Lys6Orn1, Arg(1-8)Lys5Orn2, Arg(1-8)Lys4Orn3, Arg(1-8)Lys3Orn4, Arg(1-8)Lys2Orn5, Arg(1-8)Lys1Orn6, Arg(1-8)His6Orn1, Arg(1-8)His5Orn2, Arg(1-8)His4Orn3, Arg(1-8)His3Orn4, Arg(1-8) His2Orn5, Arg(1-8)His1Orn6, Arg6Lys(1-8)His1, Arg5Lys(1-8)His2, Arg4Lys(1-8)His3, Arg3Lys(1-8)His4, Arg2Lys(1-8)His5, Arg1Lys(1-8) His6, Arg6Lys(1-8)Orn1, Arg5Lys(1-8)Orn2, Arg4Lys(1-8)Orn3, Arg3Lys(1-8) Orn4, Arg2Lys(1-8)Orn5, Arg1Lys(1-8)Orn6, Lys(1-8)His6Orn1, Lys(1-8)His5Orn2, Lys(1-8)His4Orn3, Lys(1-8)His3Orn4, Lys(1-8)His2Orn5, Lys(1-8)His1Orn6, Arg6Lys1His(1-8), Arg5Lys2His(1-8), Arg4Lys3His(1-8), Arg3Lys4His(1-8), Arg2Lys5His(1-8), Arg1Lys6His(1-8), Arg6His(1-8)Orn1, Arg5His(1-8) Orn2, Arg4His(1-8)Orn3, Arg3His(1-8)Orn4, Arg2His(1-8)Orn5, Arg1His(1-8)Orn6, Lys6His(1-8)Orn1, Lys5His(1-8)Orn2, Lys4His(1-8)Orn3, Lys3His(1-8)Orn4, Lys2His(1-8)Orn5, Lys1His(1-8)Orn6; Arg(5-12)Lys1His1Orn1, Arg1Lys(5-12)His1Orn1, Arg1Lys1His(5-12)Orn1, Arg1Lys1His1Orn(5-12); Arg(4-11)Lys2His1Orn1, Arg(4-11)Lys His2Orn1, Arg(4-11)Lys1His1Orn2, Arg2Lys(4-11)His1Orn1, Arg1Lys(4-11)His2Orn1, Arg1Lys(4-11)His1Orn2, Arg2Lys1His(4-11)Orn1, Arg1Lys2His(4-11)Orn1, Arg1Lys1His(4-11)Orn2, Arg2Lys1His1Orn(4-11) Arg1Lys2His1Orn(4-11), Arg1Lys1His2Orn(4-11); Arg(3-10)Lys3His1Orn1, Arg(3-10)Lys2His2Orn1, Arg(3-10)Lys2His1Orn2, Arg(3-10)Lys1His2Orn2, Arg(3-10) Lys1His1Orn3, Arg3Lys(3-10)His1Orn1, Arg2Lys(3-10)His2Orn1, Arg2Lys(3-10)His1Orn2, Arg1Lys(3-10) His2Orn2, Arg1Lys(3-10)His1Orn3, Arg3Lys1His(3-10)Orn1, Arg2Lys2His(3-10)Orn1, Arg2Lys1His(3-10) Orn2, Arg1Lys2His(3-10)Orn2, Arg1Lys1His(3-10)Orn3, Arg3Lys1His1Orn(3-10), Arg2Lys2His1Orn(3-10), Arg2Lys1His2Orn(3-10)Arg1Lys2His2Orn(3-10), Arg1Lys1His3Orn(3-10); Arg(2-9)Lys4His1Orn1, Arg(2-9)Lys His4Orn1, Arg(2-9)Lys1His1Orn4, Arg(2-9)Lys3His2Orn1, Arg(2-9) Lys3His1Orn2, Arg(2-9)Lys2His3Orn1, Arg(2-9)Lys2His1Orn3, Arg(2-9)Lys1His2Orn3, Arg(2-9) Lys His3Orn2, Arg(2-9)Lys2His2Orn2, Arg4Lys(2-9)His1Orn1, Arg1Lys(2-9)His4Orn1, Arg1Lys(2-9) His1Orn4, Arg3Lys(2-9)His2Orn1, Arg3Lys(2-9)His1Orn2, Arg2Lys(2-9)His3Orn1, Arg2Lys(2-9) His1Orn3, Arg1Lys(2-9)His2Orn3, Arg1Lys(2-9)His3Orn2, Arg2Lys(2-9)His2Orn2, Arg4Lys1His(2-9) Orn1, Arg1Lys4His(2-9)Orn1, Arg1Lys1His(2-9)Orn4, Arg3Lys2His(2-9)Orn1, Arg3Lys1His(2-9)Orn2, Arg2Lys3His(2-9)Orn1, Arg2Lys1His(2-9)Orn3, Arg1Lys2His(2-9)Orn3, Arg1Lys3His(2-9)Orn2, Arg2Lys2His(2-9)Orn2, Arg4Lys1His1Orn(2-9), Arg1Lys4His1Orn(2-9), Arg1Lys1His4Orn(2-9), Arg3Lys2His1Orn(2-9), Arg3Lys1His2Orn(2-9), Arg2Lys3His1Orn(2-9), Arg2Lys1His3Orn(2-9), Arg1Lys2His3Orn(2-9), Arg1Lys3His2Orn(2-9), Arg2Lys2His2Orn(2-9); Arg(1-8)Lys5His1Orn1, Arg(1-8)Lys1His5Orn1, Arg(1-8)Lys1His1Orn5, Arg(1-8)Lys4His2Orn1, Arg(1-8) Lys2His4Orn1, Arg(1-8)Lys2His1Orn4, Arg(1-8)Lys1His2Orn4, Arg(1-8)Lys1His4Orn2, Arg(1-8) Lys4His1Orn2, Arg(1-8)Lys3His3Orn1, Arg(1-8)Lys3His1Orn3, Arg(1-8)Lys1His3Orn3, Arg5Lys(1-8) His1Orn1, Arg1Lys(1-8)His5Orn1, Arg1Lys(1-8)His1Orn5, Arg4Lys(1-8)His2Orn1, Arg2Lys(1-8) His4Orn1, Arg2Lys(1-8)His1Orn4, Arg1Lys(1-8)His2Orn4, Arg1Lys(1-8)His4Orn2, Arg4Lys(1-8) His1Orn2, Arg3Lys(1-8)His3Orn1, Arg3Lys(1-8)His1Orn3, Arg1Lys(1-8)His3Orn3, Arg5Lys1His(1-8) Orn1, Arg1Lys5His(1-8)Orn1, Arg1Lys1His(1-8)Orn5, Arg4Lys2His(1-8)Orn1, Arg2Lys4His(1-8)Orn1, Arg2Lys1His(1-8)Orn4, Arg1Lys2His(1-8)Orn4, Arg1Lys4His(1-8)Orn2, Arg4Lys1His(1-8)Orn2, Arg3Lys3His(1-8)Orn1, Arg3Lys1His(1-8)Orn3, Arg1Lys3His(1-8)Orn3, Arg5Lys1His1Orn(1-8), Arg1Lys5His1Orn(1-8), Arg1Lys1His5Orn(1-8), Arg4Lys2His1Orn(1-8), Arg2Lys4His1Orn(1-8), Arg2Lys1His4Orn(1-8), Arg1Lys2His4Orn(1-8), Arg1Lys4His2Orn(1-8), Arg4Lys1His2Orn(1-8), Arg3Lys3His1Orn(1-8), Arg3Lys1His3Orn(1-8), Arg1Lys3His3Orn(1-8); According to another particular preferred aspect of the first embodiment, cationic or polycationic peptides or proteins as component P2, having the empirical formula (II) as shown above, and additionally exhibiting at least two —SH-moieties may be, without being restricted thereto, selected from following formulae: Arg8, Arg9, Arg10, Arg11, Arg12, Arg13, Arg14, Arg15; Lys8, Lys9, Lys10, Lys11, Lys12, Lys13, Lys14, Lys15; His8, His9, His10, His11, His12, His13, His14, His15; Orn8, Orn9, Orn10, Orn11, Orn12, Orn13, Orn14, Orn15; (SEQ ID NOs: 2-3, 10-39, see above).", "According to a further particular preferred aspect of the first embodiment, cationic or polycationic peptides or proteins as component P2, having the empirical formula (II) as shown above, and additionally exhibiting at least two —SH-moieties may be, without being restricted thereto, selected from the subgroup consisting of generic formulas Arg9 (also termed R9), Arg9His3 (also termed R9H3), His3Arg9His3 (also termed H3R9H3), TyrSerSerArg9SerSerTyr (also termed YSSR9SSY), His3Arg9SerSerTyr (also termed H3R9SSY), (ArgLysHis)4 (also termed (RKH)4), Tyr(ArgLysHis)2Arg (also termed Y(RKH)2R); (SEQ ID NOs: 2, 5-9, 40, see above).", "Even more preferably, these generic formulas are defined as follows: According to a one further particular preferred aspect of the first embodiment, the cationic or polycationic peptide or protein as component P2, when defined according to formula {(Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x} (formula (II)) as shown above, and additionally exhibiting at least two —SH-moieties may be, without being restricted thereto, selected from formula (IIa), preferably under the provision that at least one —SH-moiety is provided by a cysteine residue: {(Arg)l;(Lys)m;(His)n;(Orn)o;(Cys)x} (formula (IIa)) wherein (Arg)l;(Lys)m;(His)n;(Orn)o; and x are as defined herein, Alternatively, the cationic or polycationic peptide or protein as component P2, when defined according to formula {(Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x} (formula (II)) as shown above, and additionally exhibiting at least two —SH-moieties may be, without being restricted thereto, selected from formula (IIa′), preferably under the provision that at least one —SH— moiety is provided by a cysteine residue: {(Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa′)x;(Cys)y} (formula (IIa′)) wherein (Arg)l;(Lys)m;(His)n;(Orn)o; and x are as defined herein, Xaa′ is any amino acid selected from native (=naturally occurring) or non-native amino acids except of Arg, Lys, His, Orn or Cys and y is any number selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21-30, 31-40, 41-50, 51-60, 61-70, 71-80 and 81-90, provided that the overall content of Arg (Arginine), Lys (Lysine), His (Histidine) and Orn (Ornithine) represents at least 10% of all amino acids of the oligopeptide.", "These aspects of the first embodiment of the present invention may apply to situations, wherein component P2 is selected from a cationic or polycationic peptide or protein according to empirical formula (Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x (formula (II)) as shown above, which comprises or has been modified with at least one cysteine as —SH moiety in the above meaning such that the cationic or polycationic peptide as component P2 carries at least one cysteine, which is capable to form a disulfide bond with other components of formula (I).", "According to another particular preferred aspect of the first embodiment, the cationic or polycationic peptide or protein as component P2, when defined according to formula {(Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x} (formula (II)) as shown above, and preferably additionally exhibiting at least two —SH-moieties may be, without being restricted thereto, selected from formula (IIb), preferably under the provision that the at least two —SH-moieties are provided by two terminal cysteine residues: Cys {(Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x}Cys (formula (IIb)) wherein (Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x are as defined herein and form a core of amino acids according to (semiempirical) formula (II).", "Exemplary examples may comprise any of the above sequences flanked by two Cys and following sequences: Cys(Arg8)Cys, Cys(Arg9)Cys, Cys(Arg10)Cys, Cys(Arg11)Cys, Cys(Arg12)Cys, Cys(Arg13)Cys, Cys(Arg14)Cys, Cys(Arg15)Cys; Cys(Lys8)Cys, Cys(Lys9)Cys, Cys(Lys10)Cys, Cys(Lys11)Cys, Cys(Lys12)Cys, Cys(Lys13)Cys, Cys(Lys14)Cys, Cys(Lys15)Cys; Cys(His8)Cys, Cys(His9)Cys, Cys(His10)Cys, Cys(His11)Cys, Cys(His12)Cys, Cys(His13)Cys, Cys(His14)Cys, Cys(His15)Cys; Cys(Orn8)Cys, Cys(Orn9)Cys, Cys(Orn10)Cys, Cys(Orn11)Cys, Cys(Orn12)Cys, Cys(Orn13)Cys, Cys(Orn14)Cys, Cys(Orn15)Cys, (SEQ ID NOs: 41 to 72) more preferably following exemplary sequences (SEQ ID NOs: 73 to 84): CysArg9Cys: Cys-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Cys-Cys CysArg9His3Cys: Cys-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-His-His-His-Cys CysHis3Arg9His3Cys: Cys-His-His-His-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-His-His-His-Cys CysTyrSerSerArg9SerSerTyrCys: Cys-Tyr-Ser-Ser-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Ser-Ser-Tyr-Cys CysHis3Arg9SerSerTyrCys: Cys-His-His-His-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Ser-Ser-Tyr-Cys Cys (ArgLysHis)4Cys: Cys-Arg-Lys-His-Arg-Lys-His-Arg-Lys-His-Arg-Lys-His-Cys CysTyr(ArgLysHis)2ArgCys: Cys-Tyr-Arg-Lys-His-Arg-Lys-His-Arg-Cys CysHis3Arg9His3Cys: Cys-His-His-His-Arg-Arg-Arg-Arg-His-His-His-Cys CysHis6Arg9His6Cys: Cys-His-His-His-His-His-His-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-His-His-His-His-His-His-Cys CysHis3Arg4His3Cys: Cys-His-His-His-Arg-Arg-Arg-Arg-His-His-His-Cys CysHis6Arg4His6Cys Cys-His-His-His-His-His-His-Arg-Arg-Arg-Arg-His-His-His-His-His-His-Cys CysArg12Cys: Cys-Arg-Arg-Arg-Arg-Arg Arg-Arg-Arg-Arg-Arg-Arg-Arg-Cys This aspect of the first embodiment of the present invention may apply to situations, wherein the polycationic peptide or protein as component P2, e.g.", "when defined according to empirical formula (Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x (formula (II)) as shown above, has been modified with at least two (terminal) cysteines as —SH moieties in the above meaning such that component P2 carries at least two (terminal) cysteines, which are capable to form a disulfide bond with other components of formula (I).", "According to another aspect of the first embodiment, component P2 represents a cationic or polycationic polymer, selected from e.g.", "any cationic polymer suitable in this context, provided that this cationic polymer exhibits at least two —SH-moieties, which provide for a disulfide bond linking component P2 with component P1 or P3, or with further component(s) P2 or amino acid components (AA)x.", "Thus, likewise as defined herein, component P2 may occur as a repetitive component as defined herein as represented by subformula [S—P2—S]n or {[S—P2—S]a/[S-(AA)x-S]b}, wherein the same or different cationic or polycationic polymers P2 may be used in said repetitive component.", "Preferably, component P2 represents a cationic or polycationic polymer, typically exhibiting a molecular weight of about 0.5 kDa to about 100 kDa, of about 1 kDa to about 75 kDa, of about 5 kDa to about 50 kDa, of about 5 kDa to about 30 kDa, or a molecular weight of about 10 kDa to about 50 kDa, or of about 10 kDa to about 30 kDa, preferably of about 0.5 kDa to about 30 kDa, more preferably of about 1 kDa to about 20 kDa, and even more preferably of about 1.5 kDa to about 10 kDa.", "Additionally, the cationic or polycationic polymer as component P2 typically exhibits at least two —SH moieties, which are capable to form a disulfide linkage upon condensation with either components P1 or P3 or with other components P2 or amino acid components (AA)x. as defined herein.", "When component P2 represents a cationic or polycationic polymer, such a polymer may be selected from acrylates, modified acrylates, such as pDMAEMA (poly(dimethylaminoethyl methylacrylate)), chitosanes, aziridines or 2-ethyl-2-oxazoline (forming oligo ethylenimines or modified oligoethylenimines), polymers obtained by reaction of bisacrylates with amines forming oligo beta aminoesters or poly amido amines, or other polymers like polyesters, polycarbonates, etc.", "Each molecule of these cationic or polycationic polymers typically exhibits at least two —SH-moieties, wherein these at least two —SH-moieties may be introduced into the cationic or polycationic polymer by chemical modifications, e.g.", "using imonothiolan, 3-thio propionic acid or introduction of —SH-moieties containing amino acids, such as cystein, methionine or any further (modified) amino acid.", "Such —SH-moieties are preferably as already defined above for components P1, P2 or P3.Component P2 of formula (I) of the present invention preferably occurs as repetitive component [—S—P2—S-]n. Such a repetitive component [S—P2—S]n may be prepared using at least one or even more of the same or different of the above defined components P2 and polymerizing same in a polymerization condensation reaction via their —SH-moieties.", "According to one specific aspect of the first embodiment, such a repetitive component [S—P2—S]n may be prepared using at least one or even more of the same or different of the above defined cationic or polycationic peptides or proteins, and polymerizing same in a polymerization condensation reaction via their —SH-moieties.", "Accordingly, such a repetitive component [S—P2—S]n contains a number of at least one or even more of the same or different of the above defined cationic or polycationic proteins or peptides determined by integer n. According to another specific aspect of the first embodiment, such a repetitive component [S—P2—S]n may be prepared using at least one or even more of the same or different of the above defined cationic or polycationic polymers, and polymerizing same in a polymerization condensation reaction via their —SH-moieties.", "Accordingly, such a repetitive component [S—P2—S]n contains a number of at least one or even more of the same or different of the above defined cationic or polycationic polymers determined by integer n. According to a further specific aspect of the first embodiment, such a repetitive component [S—P2—S]n may be prepared using at least one or even more of the same or different of the above defined cationic or polycationic polymers and at least one or even more of the same or different of the above defined cationic or polycationic proteins or peptides, and polymerizing same in a polymerization condensation reaction via their —SH-moieties.", "Accordingly, such a repetitive component [S—P2—S]n contains a number of at least one or even more of the same or different of the above defined cationic or polycationic polymers and at least one or even more of the same or different of the above defined cationic or polycationic proteins or peptides, both together determined by integer n. According to a further aspect of the first embodiment, the inventive polymeric carrier according to formula (I) above, may comprise at least one amino acid component (AA)x, wherein AA is preferably an amino acid as defined in the following, which, when occurring as amino acid component (AA)x, allows to (substantially) modify the biophysical/biochemical properties of the inventive polymeric carrier according to formula (I) as defined herein.", "According to the present invention, the number of amino acids in such an amino acid component (AA)x (repetitions) is defined by x.", "In the above context, x is preferably an integer and may be selected from a range of about 1 to 100, preferably from a range of about 1 to 50, more preferably 1 to 30, and even more preferably selected from a number comprising 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15-30, e.g.", "from a range of about 1 to 30, from a range of about 1 to 15, or from a number comprising 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15, or may be selected from a range formed by any two of the afore mentioned values.", "Such components (AA)x may be contained in every parts of the inventive polymeric carrier according to formula (I) above and therefore may be attached to all components of the inventive polymeric carrier according to formula (I).", "It is particularly preferred that (AA)x is present as ligand or part of the repetitive component [S—P2—S]n. In this contex it is particularly preferred that the amino acid component (AA)x contains or is flanked (e.g.", "terminally) by at least one —SH containing moiety, which allows introducing this component (AA)x via a disulfide bond into the polymeric carrier according to formula (I) as defined herein.", "In this context, the amino acid component (AA)x may also be read as a component —S-(AA)x- or —S-(AA)x-S—, wherein S represents a —SH containing moiety (or, of course, one sulfur of a disulfide bond), e.g.", "a cysteine residue.", "In the specific case that the —SH containing moiety represents a cysteine, the amino acid component (AA)x may also be read as -Cys-(AA)x- or -Cys-(AA)x-Cys- wherein Cys represents Cysteine and provides for the necessary —SH-moiety for a disulfide bond.", "(Accordingly, -Cys-(AA)x-Cys- may also be written as —(S-Cys)-(AA)x-(Cys-S)— and -Cys-(AA)x-may also be written as —(S-Cys)-(AA)x-).)", "The —SH containing moiety may be also introduced into the amino acid component (AA)x using any of modifications or reactions as shown above for components P1, P2 or P3.In the specific case that the amino acid component (AA)x is linked to two components of the inventive polymeric carrier according to formula (I) it is preferred that (AA)x contains at least two —SH-moieties, e.g.", "at least two Cysteines, preferably at its terminal ends.", "This is particularly preferred if (AA)x is part of the repetitive component [S—P2—S]n. In an alternative the amino acid component (AA)x is introduced into the inventive polymeric carrier according to formula (I) as defined herein via any chemical possible addition reaction.", "Therefore the amino acid component (AA)x contains at least one further functional moiety, which allows attaching same to a further component as defined herein, e.g.", "component P1 or P3, P2, L, or a further amino acid component (AA)x, etc.", "Such functional moieties may be selected from functionalities which allow the attachment of further components, e.g.", "functionalities as defined herein, e.g.", "by amide formation (e.g.", "carboxylic acids, sulphonic acids, amines, etc.", "), by Michael addition (e.g maleinimide moieties, α,β unsatured carbonyls, etc.", "), by click chemistry (e.g.", "azides or alkines), by alkene/alkine methatesis (e.g.", "alkenes or alkines), imine or hydrozone formation (aldehydes or ketons, hydrazins, hydroxylamins, amines), complexation reactions (avidin, biotin, protein G) or components which allow Sn-type substitution reactions (e.g halogenalkans, thiols, alcohols, amines, hydrazines, hydrazides, sulphonic acid esters, oxyphosphonium salts) or other chemical moieties which can be utilized in the attachment of further components.", "The amino acid component (AA)x may also occur as a mixed repetitive amino acid component [(AA)x]z, wherein the number of amino acid components (AA)x is further defined by z.", "In this context, z is an integer and may be selected from a range of about 1 to 30, preferably from a range of about 1 to 15, more preferably 1 to 10 or 1 to 5 and even more preferably selected from a number selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15, or may be selected from a range formed by any two of the afore mentioned values.", "Such a mixed repetitive amino acid component [(AA)x], may be used to integrate several of the same or different amino acid components (AA)x as defined herein in the inventive polymeric carrier.", "Preferably, in the mixed repetitive amino acid component [(AA)]z the amino acid component (AA)) may contain or may be flanked (e.g.", "terminally) by at least one —SH containing moiety, preferably at least two —SH containing moieties as already defined above, which allows coupling the different amino acid components (AA)x using a disulfide bond via a condensation polymerization.", "Likewise as above, the mixed repetitive amino acid component [(AA)x], may also be read as [S-(AA)x-S]z, wherein S represents a —SH containing moiety, e.g.", "a cysteine residue.", "In the specific case that the —SH containing moiety represents a cysteine, the mixed repetitive amino acid component [(AA)x]z may also be read as [Cys-(AA)x-Cys]z, wherein Cys represents Cysteine and provides for the necessary —SH-moiety for a disulfide bond.", "The —SH containing moiety may be also introduced into the amino acid component (AA)x using any of modifications or reactions as shown above for components P1, P2 or P3.The amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x]z may be provided with at least one —SH-moiety, e.g.", "in a form represented by formula (AA)x-SH.", "Then, the component (AA)x according to formula (AA)x-SH or the mixed repetitive amino acid component [(AA)x]z according to formula [(AA)x]z—SH, may be bound to any of components L, P1, P2 and/or P3 or another component (AA)x via a disulfide bond.", "If bound to component P1 and/or component P3, components P1 and/or P3 preferably exhibit at least two —SH-moieties to allow further binding of components P1 and/or P3 to a component P2 via a —SH-moiety forming a disulfide bond (see above).", "The amino acid component (AA)x in a form represented by formula (AA)x-SH or the mixed repetitive amino acid component [(AA)x]z according to formula [(AA)x]z—SH may be also used to terminate a condensation reaction due to its single —SH moiety.", "In this case, the amino acid component (AA)x in a form represented by formula (AA)x-SH is preferably coupled terminally to components P1 and/or P3.The amino acid component (AA)x in a form represented by formula (AA)x-SH or the mixed repetitive amino acid component [(AA)x]Z according to formula [(AA)x]z—SH may be also used to bind internally to any of components L, P1, P2 and/or P3 or a further component (AA)x via a further internal —SH-moiety of any of components L, P1, P2 and/or P3 or (AA)x.", "Furthermore, the amino acid component (AA)x may be provided with two —SH-moieties (or even more), e.g.", "in a form represented by formula HS-(AA)x-SH.", "Additionally, the mixed repetitive amino acid component [(AA)x]z may be provided with two —SH-moieties (or even more), e.g.", "in a form represented by formula HS—[(AA)x]z—SH, to allow binding to two functionalities via disulfide bonds, e.g.", "if the amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x]z is used as a linker between two further components (e.g.", "as a linker between components L and P1, between components P1 and P2, in or as a part of repetitive component [S—P2—S]n, between components P2 and P3 and/or between components P3 and L).", "In this case, one —SH moiety is preferably protected in a first step using a protecting group as known in the art, leading to an amino acid component (AA)x of formula HS-(AA)x-S-protecting group or to a mixed repetitive amino acid component [(AA)x]z of formula HS—[(AA)x]z—S-protecting group.", "Then, the amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x]z may be bound to a component L, P1, P2 and/or P3, to form a first disulfide bond via the non-protected —SH moiety.", "The protected-SH-moiety is then typically deprotected and bound to a further free —SH-moiety of a further component L, P1, P2 and/or P3 to form a second disulfide bond.", "In the case that the amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x]z is part of the repetitive component [S—P2—S]n it is preferred that the formation of the disulfide bonds between (AA)x and P2 concurrently occurs with the polycondensation reaction of the repetitive component [S—P2—S]n and therefore no protection of the at least two terminal —SH-moieties is not necessary.", "Alternatively, the amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x]z may be provided with other functionalities as already described above for components P1 and P2 and/or P3, which allow binding of the amino acid component (AA)x or binding of the mixed repetitive amino acid component [(AA)x]z to any of components P1, P2 and/or P3 or (AA)x and optionally to component L. Thus, according to the present invention, the amino acid component (AA)x and/or the mixed repetitive amino acid component [(AA)x]z may be bound to P1, P2, P3, (AA)x and/or L with or without using a disulfide linkage.", "Binding without using a disulfide linkage may be accomplished by any of the reactions described above, preferably by binding the amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x]z to P1, P2, P3, (AA)x and/or L using an amid-chemistry as defined herein.", "If desired or necessary, the other terminus of the amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x]z, e.g.", "the N- or C-terminus, may be used to couple another component, e.g.", "a ligand L. For this purpose, the other terminus of the amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x], preferably comprises or is modified to comprise a further functionality, e.g.", "an alkyn-species (see above), which may be used to add the other component via e.g.", "click-chemistry.", "Such a construct, e.g.", "L-(AA)x-P1—S— or L-[(AA)x]z-P1—S—, may be used to terminate the polymerization condensation reaction of repetitive component [S—P2—S]n. If the ligand is bound via an acid-labile bond, the bond may be cleaved off in the endosome and the inventive polymeric carrier presents amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x]z at its surface.", "The amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x]z may occur as a further component of generic formula (I) above, e.g.", "as a linker between components P1 or P3 and P2, as a linker between components L and P1 or P2 or as an additional component of the repetitive component [S—P2—S]n. According to a first alternative, such an amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x]Z may be present as a linker between components P1 or P3 and component P2.This is preferably represented in the context of the entire inventive polymeric carrier according to formula (I) by following formulae: L-P1—S—S-(AA)x-S—[S—P2—S]n—S-(AA)x-S—S—P3-L, or L-P1—S—[S-(AA)x-S]z—[S—P2—S]n—[S-(AA)x-S]z—S—P3-L, wherein n, x, z, S, L, AA, P1, P2 and P3 are preferably as defined herein.", "In the above formulae, the term “—S—S—” represents a disulfide bond, wherein this at least one sulfur of the disulfide bond may also be provided by a cysteine.", "In this case, the term “—S—S—” in these formulae may also be written as “—S-Cys”, as “-Cys-S” or as “-Cys-Cys-”.", "In this context, the term “-Cys-Cys-” does not represent a peptide bond but a linkage of two cysteines via their —SH-moieties to form a disulfide bond.", "Accordingly, the term “-Cys-Cys-” may also be understood generally as “-(Cys-S)—(S-Cys)-”, wherein in this specific case S indicates the sulfur of the —SH-moiety of cysteine.", "Likewise, the terms “—S-Cys” and “-Cys-S” indicate a disulfide bond between a —SH containing moiety and a cysteine, which may also be written as “—S—(S-Cys)” and “-(Cys-S)—S”.", "According to a second alternative, such an amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x], may be present as a linker between components P1 or P3 and component L. This is preferably represented in the context of the entire inventive polymeric carrier according to formula (I) by following formulae: L-(AA)x-P1—S—[S—P2—S]n—S—P3-(AA)x-L, or L-[(AA)x]z-P1—S—[S—P2—S]n—S—P3—[(AA)x]z-L, or alternatively L-(AA)x-S—S—P1—S—[S—P2—S]n—S—P3—S—S-(AA)x-S—S-L, or L-S—S-(AA)x-S—S—P1—S—[S—P2—S]n—S—P3—S—S-(AA)x-S—S-L, or L-S—[S-(AA)x-S]z—S—P1—S—[S—P2—S]n—S—P3—S—[S-(AA)x-S]z—S-L, etc.", "wherein n, x, z, S, L, AA, P1, P2 and P3 are preferably as defined herein.", "In the above formulae, the term “—S—S—” represents a disulfide bond, as already defined above.", "According to a third alternative, such an amino acid component (AA)x or the mixed repetitive amino acid component [(AA)x]z may be present as a part of components P1 and/or P3, wherein the amino acid component (AA)x may be directly bound to (e.g.", "the terminus of) component P1 and/or P3 without a further ligand L. In this case the (AA)x component may be in the form of a ligand as defined above.", "This is preferably represented in the context of the entire inventive polymeric carrier according to formula (I) by following formulae: (AA)x-P1—S—[S—P2—S]n—S—P3-(AA)x, or [(AA)x]z-P1—S—[S—P2—S]n—S—P3—[(AA)x], or or alternatively (AA)x-S—S—P1—S—[S—P2—S]n—S—P3—S—S-(AA)x, or H—[S-(AA)x-S]z—S—P1—S—[S—P2—S]n—S—S—P3—S—[S-(AA)x-S]z—H, wherein n, x, z, S, AA, P1, P2 and P3 are preferably as defined herein.", "In the above formulae, the term “—S—S—” represents a disulfide bond, as already defined above.", "The free —SH moiety at the terminal ends in the last formula may also be terminated using a monothiol compound as defined herein.", "According to a fourth and particularly preferred alternative, the amino acid component (AA)x, preferably written as S-(AA)x-S or [S-(AA)x-S] may be used to modify component P2, particularly the content of component S—P2—S in repetitive component [S—P2—S]n of formula (I) above.", "This may be represented in the context of the entire polymeric carrier according to formula (I) e.g.", "by following formula (Ia): L-P1—S—{[S—P2—S]a[S-(AA)x-Sb}—S—P3-L, wherein x, S, L, AA, P1, P2 and P3 are preferably as defined herein.", "In formula (Ia) above, any of the single components [S—P2—S] and [S-(AA)x-S] may occur in any order in the subformula {[S—P2—S]a[S-(AA)x-S]b}.", "The numbers of single components [S—P2—S] and [S-(AA)x-S] in the subformula {[S—P2—S]a[S-(AA)x-S]b} are determined by integers a and b, wherein a+b=n.", "n is an integer and is defined as above for formula (I).", "a is an integer, typically selected independent from integer b from a range of about 1 to 50, preferably from a range of about 1, 2 or 3 to 30, more preferably from a range of about 1, 2, 3, 4, or 5 to 25, or a range of about 1, 2, 3, 4, or 5 to 20, or a range of about 1, 2, 3, 4, or 5 to 15, or a range of about 1, 2, 3, 4, or 5 to 10, including e.g.", "a range of about 3 to 20, 4 to 20, 5 to 20, or 10 to 20, or a range of about 3 to 15, 4 to 15, 5 to 15, or 10 to 15, or a range of about 6 to 11 or 7 to 10.Most preferably, a is in a range of about 1, 2, 3, 4, or 5 to 10, more preferably in a range of about 1, 2, 3, or 4 to 9, in a range of about 1, 2, 3, or 4 to 8, or in a range of about 1, 2, or 3 to 7.b is an integer, typically selected independent from integer a from a range of about 0 to 50 or 1 to 50, preferably from a range of about 0, 1, 2 or 3 to 30, more preferably from a range of about 0, 1, 2, 3, 4, or 5 to 25, or a range of about 0, 1, 2, 3, 4, or 5 to 20, or a range of about 0, 1, 2, 3, 4, or 5 to 15, or a range of about 0, 1, 2, 3, 4, or 5 to 10, including e.g.", "a range of about 3 to 20, 4 to 20, 5 to 20, or 10 to 20, or a range of about 3 to 15, 4 to 15, 5 to 15, or 10 to 15, or a range of about 6 to 11 or 7 to 10.Most preferably, b is in a range of about 1, 2, 3, 4, or 5 to 10, more preferably in a range of about 1, 2, 3, or 4 to 9, in a range of about 1, 2, 3, or 4 to 8, or in a range of about 1, 2, or 3 to 7.In the above formula, the term “—S—S—” (the brackets are omitted for better readability) represents a disulfide bond as already defined above.", "The modification of component P2, particularly of component S—P2—S of repetitive component [S—P2—S]n, by “diluting” same with amino acid components (AA)x may be also realized in the context of any of the afore mentioned alternatives of the entire polymeric carrier according to formula (I), L-P1—S—S-(AA)x-S—{[S—P2—S]a[S-(AA)x-S]b}—S-(AA)x-S—S—P-L, or L-P1—S—[S-(AA)x-S]z—{[S—P2—S]a[S-(AA)x-S]b}—[S-(AA)x-S]z—S—P3-L, or L-(AA)x-P1—S—{[S—P2—S]a[S-(AA)x-S]b}—S—P3-(AA)x-L, or L-[(AA)x]zP1—S—{[S—P2—S]a[S-(AA)x-S]b}—S—P3-[(AA)x]z-L, or L-(AA)x-S—S—P1—S—{[S—P2—S]a[S-(AA)x-S]b}—S—P3—S—S-(AA)x-S—S-L, or L-S—S-(AA)x-S—S—P1—S—{[S—P2—S]a[S-(AA)x-S]b}—S—P3—S—S-(AA)x-S—S-L, or L-S—[S-(AA)x-S]z—S—P1—S—{[S—P2—S]a[S-(AA)x-S]b}—S—P3—S—[S-(AA)x-S]z—S-L, or (AA)x-P1—S—{[S—P2—S]a[S-(AA)x-S]b}—S—P3-(AA)x, or [(AA)x]-P1—S—{[S—P2—S]a[S-(AA)x-S]b}—S—P3-[(AA)x], or (AA)x-S—S—P1—S—{[S—P2—S]a[S-(AA)x-S]b}—S—P3—S—S-(AA)x, or H—[S-(AA)x-S]z—S—P1—S—{[S—P2—S]a[S-(AA)x-S]b}—S—P3—S—[S-(AA)x-S]z—H, wherein n, x, z, a, b, S, L, AA, P1, P2 and P3 are preferably as defined herein.", "Likewise, the term “—S—S—” represents a disulfide bond and is preferably as defined herein.", "In the above alternatives, wherein the component [S—P2—S] is preferably “diluted” with amino acid components [S-(AA)x-S], the ratio is determined by integers a and b, wherein a+b=n.", "Preferably, integers a and b are selected such that the cationic binding properties of component [S—P2—S] are not lost but remain to a minimum extent in subformula/component {[S—P2—S]a[S-(AA)x-S]b}.", "This allows to weaken (“dilute”) the cationic binding strength of component [S—P2—S] in repetitive component [S—P2—S]n of inventive polymeric carrier of formula (I) to a desired extent.", "In this specific context the (desired) cationic binding strength of subformula/component {[S—P2—S]a[S-(AA)x-S]b} may be determined using different methods.", "According to a first alternative, component P2 of formula (I) of the present invention is particularly preferable a cationic or polycationic peptide as defined herein.", "Furthermore, the amino acid component (AA)x, preferably written as [S-(AA)x-S], typically resembles a peptide sequence.", "In this specific case, the cationic properties of subformula/component {[S—P2-s]a[S-(AA)x-S]b} may be determined upon their content of cationic amino acids in the entire subformula/component.", "Preferably, the content of cationic amino acids in subformula/component {[S—P2—S]a[S-(AA)x-S]b} is at least 10%, 20%, or 30%, preferably at least 40%, more preferably at least 50%, 60% or 70%, but also preferably at least 80%, 90%, or even 95%, 96%, 97%, 98%, 99% or 100%, most preferably at least 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99% or 100%, or may be in the range of about 10% to 90%, more preferably in the range of about 15% to 75%, even preferably in the range of about 20% to 50%, e.g.", "20, 30, 40 or 50%, or in a range formed by any two of the afore mentioned values, provided, that the content of all amino acids, e.g.", "cationic, lipophilic, hydrophilic, aromatic and further amino acids, in the entire subformula/component {[S—P2—S]a[S-(AA)x-S]b} is 100%.", "According to a second alternative, component P2 of formula (I) of the present invention is particularly preferable a cationic or polycationic polymer as defined herein.", "The amino acid component (AA)x, preferably written as [S-(AA)x-S], typically resembles a peptide sequence.", "In this specific case, the cationic properties of subformula/component {[S—P2—S]a[S-(AA)x-S]b} may be determined upon their content of cationic charges in the entire subformula/component.", "Preferably, the content of cationic charges in subformula/component {[S—P2—S]a[S-(AA)x-S]b} at a (physiological) pH as defined herein is at least 10%, 20%, or 30%, preferably at least 40%, more preferably at least 50%, 60% or 70%, but also preferably at least 80%, 90%, or even 95%, 96%, 97%, 98%, 99% or 100%, most preferably at least 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99% or 100%, or may be in the range of about 10% to 90%, more preferably in the range of about 15% to 75%, even preferably in the range of about 20% to 50%, e.g.", "20, 30, 40 or 50%, or in a range formed by any two of the afore mentioned values, provided, that the content of all charges, e.g.", "positive and negative charges at a (physiological) pH as defined herein, in the entire subformula/component {[S—P2—S]a[S-(AA)x-S]b} is 100%.", "In the context of the present invention, the amino acid component (AA)x may be selected from the following alternatives.", "According to a first alternative, the amino acid component (AA)x may be an aromatic amino acid component (AA)x.", "The incorporation of aromatic amino acids or sequences as an amino aromatic acid component (AA)x into the inventive polymeric carrier according to formula (I) of the present invention enables a different (second) binding of the inventive polymeric carrier to the nucleic acid due to interactions of the aromatic amino acids with the bases of the nucleic acid cargo in contrast to the binding thereof by cationic charged sequences of the polymeric carrier molecule to the phosphate backbone.", "This interaction may occur e.g.", "by intercalations or by minor or major groove binding.", "This kind of interaction is not prone to decompaction by anionic complexing partners (e.g.", "Heparin, Hyaluronic acids) which are found mainly in the extracellular matrix in vivo and is also less susceptible to salt effects.", "For this purpose, the amino acid AA in the aromatic amino acid component (AA)x may be selected from either the same or different aromatic amino acids e.g.", "selected from Trp, Tyr, or Phe.", "Alternatively, the amino acid AA (or the entire aromatic amino acid component (AA)x) may be selected from following peptide combinations Trp-Tyr, Tyr-Trp, Trp-Trp, Tyr-Tyr, Trp-Tyr-Trp, Tyr-Trp-Tyr, Trp-Trp-Trp, Tyr-Tyr-Tyr, Trp-Tyr-Trp-Tyr, Tyr-Trp-Tyr-Trp, Trp-Trp-Trp-Trp, Phe-Tyr, Tyr-Phe, Phe-Phe, Phe-Tyr-Phe, Tyr-Phe-Tyr, Phe-Phe-Phe, Phe-Tyr-Phe-Tyr, Tyr-Phe-Tyr-Phe, Phe-Phe-Phe-Phe, Phe-Trp, Trp-Phe, Phe-Phe, Phe-Trp-Phe, Trp-Phe-Trp, Phe-Trp-Phe-Trp, Trp-Phe-Trp-Phe, or Tyr-Tyr-Tyr-Tyr, etc.", "(SEQ ID NOs: 85-112) or combinations thereof.", "Additionally, the aromatic amino acid component (AA)x may contain or may be flanked by a —SH containing moiety, which allows introducing this component via a disulfide bond as a further part of generic formula (I) above, e.g.", "as a linker or more preferably as a component of the repetitive component [S—P2—S]n. Such a —SH containing moiety may be any moiety as defined herein suitable to couple one component as defined herein to a further component as defined herein.", "As an example, such a —SH containing moiety may be a cysteine.", "Then, e.g.", "the aromatic amino acid component (AA)x may be selected from e.g.", "peptide combinations Cys-Tyr-Cys, Cys-Trp-Cys, Cys-Trp-Tyr-Cys, Cys-Tyr-Trp-Cys, Cys-Trp-Trp-Cys, Cys-Tyr-Tyr-Cys, Cys-Trp-Tyr-Trp-Cys, Cys-Tyr-Trp-Tyr-Cys, Cys-Trp-Trp-Trp-Cys, Cys-Tyr-Tyr-Tyr-Cys, Cys-Trp-Tyr-Trp-Tyr-Cys, Cys-Tyr-Trp-Tyr-Trp-Cys, Cys-Trp-Trp-Trp-Trp-Cys, Cys-Tyr-Tyr-Tyr-Tyr-Cys, Cys-Phe-Cys, Cys-Phe-Tyr-Cys, Cys-Tyr-Phe-Cys, Cys-Phe-Phe-Cys, Cys-Tyr-Tyr-Cys, Cys-Phe-Tyr-Phe-Cys, Cys-Tyr-Phe-Tyr-Cys, Cys-Phe-Phe-Phe-Cys, Cys-Tyr-Tyr-Tyr-Cys, Cys-Phe-Tyr-Phe-Tyr-Cys, Cys-Tyr-Phe-Tyr-Phe-Cys, or Cys-Phe-Phe-Phe-Phe-Cys, Cys-Phe-Trp-Cys, Cys-Trp-Phe-Cys, Cys-Trp-Trp-Cys, Cys-Phe-Trp-Phe-Cys, Cys-Trp-Phe-Trp-Cys, Cys-Phe-Trp-Phe-Trp-Cys, Cys-Trp-Phe-Trp-Phe-Cys, etc.", "(SEQ ID NOs: 113-145) or combinations thereof.", "Each Cys above may also be replaced by any modified peptide or chemical compound carrying a free —SH-moiety as defined herein.", "Additionally, the aromatic amino acid component (AA)x may contain at least one proline, which may serve as a structure breaker of longer repetitive sequences of Trp, Tyr and Phe in the aromatic amino acid component (AA)x, preferably two, three or more prolines.", "According to a second alternative, the amino acid component (AA)x may be a hydrophilic (and preferably non charged polar) amino acid component (AA)x.", "The incorporation of hydrophilic (and preferably non charged polar) amino acids or sequences as amino hydrophilic (and preferably non charged polar) acid component (AA)x into the inventive polymeric carrier according to formula (I) of the present invention enables a more flexible binding to the nucleic acid cargo.", "This leads to a more effective compaction of the nucleic acid cargo and hence to a better protection against nucleases and unwanted decompaction.", "It also allows provision of a (long) inventive polymeric carrier according to formula (I) which exhibits a reduced cationic charge over the entire carrier or preferably within repetitive component [S—P2—S]n and in this context to better adjusted binding properties, if desired or necessary.", "For this purpose, the amino acid AA in the hydrophilic (and preferably non charged polar) amino acid component (AA)x may be selected from either the same or different hydrophilic (and preferably non charged polar) amino acids e.g.", "selected from Thr, Ser, Asn or Gin.", "Alternatively, the amino acid AA (or the entire hydrophilic (and preferably non charged polar) amino acid component (AA)x) may be selected from following peptide combinations Ser-Thr, Thr-Ser, Ser-Ser, Thr-Thr, Ser-Thr-Ser, Thr-Ser-Thr, Ser-Ser-Ser, Thr-Thr-Thr, Ser-Thr-Ser-Thr, Thr-Ser-Thr-Ser, Ser-Ser-Ser-Ser, Thr-Thr-Thr-Thr, Gln-Asn, Asn-Gln, Gin-Gin, Asn-Asn, Gln-Asn-Gln, Asn-Gln-Asn, Gln-Gln-Gln, Asn-Asn-Asn, Gln-Asn-Gln-Asn, Asn-Gln-Asn-Gln, Gin-Gin-Gin-Gin, Asn-Asn-Asn-Asn, Ser-Asn, Asn-Ser, Ser-Ser, Asn-Asn, Ser-Asn-Ser, Asn-Ser-Asn, Ser-Ser-Ser, Asn-Asn-Asn, Ser-Asn-Ser-Asn, Asn-Ser-Asn-Ser, Ser-Ser-Ser-Ser, or Asn-Asn-Asn-Asn, etc.", "(SEQ ID NOs: 146-181) or combinations thereof.", "Additionally, the hydrophilic (and preferably non charged polar) amino acid component (AA)x may contain or may be flanked by a —SH containing moiety, which allows introducing this component via a disulfide bond as a further part of generic formula (I) above, e.g.", "as a linker or more preferably as component of the repetitive component [S—P2—S]n. Such a —SH containing moiety may be any moiety as defined herein suitable to couple one component as defined herein to a further component as defined herein.", "As an example, such a —SH containing moiety may be a cysteine.", "Then, e.g.", "the hydrophilic (and preferably non charged polar) amino acid component (AA)x may be selected from e.g.", "peptide combinations Cys-Thr-Cys, Cys-Ser-Cys, Cys-Ser-Thr-Cys, Cys-Thr-Ser-Cys, Cys-Ser-Ser-Cys, Cys-Thr-Thr-Cys, Cys-Ser-Thr-Ser-Cys, Cys-Thr-Ser-Thr-Cys, Cys-Ser-Ser-Ser-Cys, Cys-Thr-Thr-Thr-Cys, Cys-Ser-Thr-Ser-Thr-Cys, Cys-Thr-Ser-Thr-Ser-Cys, Cys-Ser-Ser-Ser-Ser-Cys, Cys-Thr-Thr-Thr-Thr-Cys, Cys-Asn-Cys, Cys-Gln-Cys, Cys-Gln-Asn-Cys, Cys-Asn-Gln-Cys, Cys-Gln-Gln-Cys, Cys-Asn-Asn-Cys, Cys-Gln-Asn-Gln-Cys, Cys-Asn-Gln-Asn-Cys, Cys-Gln-Gln-Gln-Cys, Cys-Asn-Asn-Asn-Cys, Cys-Gin-Asn-Gln-Asn-Cys, Cys-Asn-Gin-Asn-Gin-Cys, Cys-G In-Gln-Gln-Gln-Cys, Cys-Asn-Asn-Asn-Asn-Cys, Cys-Asn-Cys, Cys-Ser-Cys, Cys-Ser-Asn-Cys, Cys-Asn-Ser-Cys, Cys-Ser-Ser-Cys, Cys-Asn-Asn-Cys, Cys-Ser-Asn-Ser-Cys, Cys-Asn-Ser-Asn-Cys, Cys-Ser-Ser-Ser-Cys, Cys-Asn-Asn-Asn-Cys, Cys-Ser-Asn-Ser-Asn-Cys, Cys-Asn-Ser-Asn-Ser-Cys, Cys-Ser-Ser-Ser-Ser-Cys, or Cys-Asn-Asn-Asn-Asn-Cys, etc.", "(SEQ ID NOs: 182-223) or combinations thereof.", "Each Cys above may also be replaced by any modified peptide or chemical compound carrying a free —SH-moiety as defined herein.", "Additionally, the hydrophilic (and preferably non charged polar) amino acid component (AA)x may contain at least one proline, which may serve as a structure breaker of longer repetitive sequences of Ser, Thr and Asn in the hydrophilic (and preferably non charged polar) amino acid component (AA)x, preferably two, three or more prolines.", "According to a third alternative, the amino acid component (AA)x may be a lipophilic amino acid component (AA)x.", "The incorporation of lipophilic amino acids or sequences as amino lipophilic acid component (AA)x into the inventive polymeric carrier according to formula (I) of the present invention enables a stronger compaction of the nucleic acid cargo and/or the polymeric carrier according to formula (I) and its nucleic acid cargo when forming a complex.", "This is particularly due to interactions of one or more polymer strands of the inventive polymeric carrier, particularly of lipophilic sections of lipophilic amino acid component (AA)x, preferably in the context of subformula/component {[S—P2—S]a[S-(AA)x-S]b}, and the nucleic acid cargo.", "This interaction will preferably add an additional stability to the complex between the polymeric carrier according to formula (I) and its nucleic acid cargo.", "This stabilization may somehow be compared to a sort of non covalent crosslinking between different polymer strands.", "Especially in aqueous environment this interaction is typically strong and provides a significant effect.", "For this purpose, the amino acid AA in the lipophilic amino acid component (AA)x may be selected from either the same or different lipophilic amino acids e.g.", "selected from Leu, Val, Ile, Ala, Met.", "Alternatively, the amino acid AA (or the entire lipophilic amino acid component (AA)x) may be selected from following peptide combinations Leu-Val, Val-Leu, Leu-Leu, Val-Val, Leu-Val-Leu, Val-Leu-Val, Leu-Leu-Leu, Val-Val-Val, Leu-Val-Leu-Val, Val-Leu-Val-Leu, Leu-Leu-Leu-Leu, Val-Val-Val-Val, Ile-Ala, Ala-Ile, Ile-Ile, Ala-Ala, Ile-Ala-lie, Ala-Ile-Ala, Ile-Ile-Ile, Ala-Ala-Ala, Ile-Ala-Ile-Ala, Ala-Ile-Ala-Ile, Ile-Ile-Ile-Ile, Ala-Ala-Ala-Ala, Met-Ala, Ala-Met, Met-Met, Ala-Ala, Met-Ala-Met, Ala-Met-Ala, Met-Met-Met, Ala-Ala-Ala, Met-Ala-Met-Ala, Ala-Met-Ala-Met, or Met-Met-Met-Met etc.", "(SEQ ID NOs: 224-258) or combinations thereof.", "Additionally, the lipophilic amino acid component (AA)x may contain or may be flanked by a —SH containing moiety, which allows introducing this component via a disulfide bond as a further part of generic formula (I) above, e.g.", "as a linker or more preferably as component of the repetitive component [S—P2—S]n. Such a —SH containing moiety may be any moiety as defined herein suitable to couple one component as defined herein to a further component as defined herein.", "As an example, such a —SH containing moiety may be a cysteine.", "Then, e.g.", "the lipophilic amino acid component (AA)x may be selected from e.g.", "peptide combinations Cys-Val-Cys, Cys-Leu-Cys, Cys-Leu-Val-Cys, Cys-Val-Leu-Cys, Cys-Leu-Leu-Cys, Cys-Val-Val-Cys, Cys-Leu-Val-Leu-Cys, Cys-Val-Leu-Val-Cys, Cys-Leu-Leu-Leu-Cys, Cys-Val-Val-Val-Cys, Cys-Leu-Val-Leu-Val-Cys, Cys-Val-Leu-Val-Leu-Cys, Cys-Leu-Leu-Leu-Leu-Cys, Cys-Val-Val-Val-Val-Cys, Cys-Ala-Cys, Cys-Ile-Cys, Cys-Ile-Ala-Cys, Cys-Ala-ile-Cys, Cys-Ile-Ile-Cys, Cys-Ala-Ala-Cys, Cys-Ile-Ala-Ile-Cys, Cys-Ala-Ile-Ala-Cys, Cys-Ile-Ile-Ile-Cys, Cys-Ala-Ala-Ala-Cys, Cys-Ile-Ala-ile-Ala-Cys, Cys-Ala-Ile-Ala-Ile-Cys, Cys-Ile-Ile-Ile-Ile-Cys, or Cys-Ala-Ala-Ala-Ala-Cys, Cys-Met-Cys, Cys-Met-Ala-Cys, Cys-Ala-Met-Cys, Cys-Met-Met-Cys, Cys-Ala-Ala-Cys, Cys-Met-Ala-Met-Cys, Cys-Ala-Met-Ala-Cys, Cys-Met-Met-Met-Cys, Cys-Ala-Ala-Ala-Cys, Cys-Met-Ala-Met-Ala-Cys, Cys-Ala-Met-Ala-Met-Cys, Cys-Met-Met-Met-Met-Cys, or Cys-Ala-Ala-Ala-Ala-Cys, etc.", "(SEQ ID NOs: 289-299) or combinations thereof.", "Each Cys above may also be replaced by any modified peptide or chemical compound carrying a free —SH-moiety as defined herein.", "Additionally, the lipophilic amino acid component (AA)x may contain at least one proline, which may serve as a structure breaker of longer repetitive sequences of Leu, Val, lie, Ala and Met in the lipophilic amino acid component (AA)x, preferably two, three or more prolines.", "According to a fourth alternative, the amino acid component (AA)x may be a weak basic amino acid component (AA)x.", "The incorporation of weak basic amino acids or sequences as weak basic amino acid component (AA)x into the inventive polymeric carrier according to formula (I) of the present invention may serve as a proton sponge and facilitates endosomal escape (also called endosomal release) (proton sponge effect).", "Incorporation of such a weak basic amino acid component (AA)x preferably enhances transfection efficiency.", "For this purpose, the amino acid AA in the weak basic amino acid component (AA)x may be selected from either the same or different weak amino acids e.g.", "selected from histidine or aspartate (aspartic acid).", "Alternatively, the weak basic amino acid AA (or the entire weak basic amino acid component (AA).)", "may be selected from following peptide combinations Asp-His, His-Asp, Asp-Asp, His-His, Asp-His-Asp, His-Asp-His, Asp-Asp-Asp, His-His-His, Asp-His-Asp-His, His-Asp-His-Asp, Asp-Asp-Asp-Asp, or His-His-His-His, etc.", "(SEQ ID NOs: 300-311) or combinations thereof.", "Additionally, the weak basic amino acid component (AA)x may contain or may be flanked by a —SH containing moiety, which allows introducing this component via a disulfide bond as a further part of generic formula (I) above, e.g.", "as a linker or more preferably as component of the repetitive component [S—P2—S]n. Such a —SH containing moiety may be any moiety as defined herein suitable to couple one component as defined herein to a further component as defined herein.", "As an example, such a —SH containing moiety may be a cysteine.", "Then, e.g.", "the weak basic amino acid component (AA)x may be selected from e.g.", "peptide combinations Cys-His-Cys, Cys-Asp-Cys, Cys-Asp-His-Cys, Cys-His-Asp-Cys, Cys-Asp-Asp-Cys, Cys-His-His-Cys, Cys-Asp-His-Asp-Cys, Cys-His-Asp-His-Cys, Cys-Asp-Asp-Asp-Cys, Cys-His-His-His-Cys, Cys-Asp-His-Asp-His-Cys, Cys-His-Asp-His-Asp-Cys, Cys-Asp-Asp-Asp-Asp-Cys, or Cys-His-His-His-His-Cys, etc.", "(SEQ ID NOs: 312-325) or combinations thereof.", "Each Cys above may also be replaced by any modified peptide or chemical compound carrying a free —SH-moiety as defined herein.", "Additionally, the weak basic amino acid component (AA)x may contain at least one proline, which may serve as a structure breaker of longer repetitive sequences of histidine or aspartate (aspartic acid) in the weak basic amino acid component (AA)x, preferably two, three or more prolines.", "Additionally, the inventive polymeric carrier according to formula (I) above (or according to any of its subformulas herein), may comprise as an additional component, preferably as a ligand L or as an amino acid component (AA)x a signal peptide, a localization signal or sequence or a nuclear localization signal or sequence (NLS), which allows a translocalization of the inventive polymeric carrier according to formula (I) above to a specific target, e.g.", "into the cell, into the nucleus, into the endosomal compartment, sequences for the mitochondrial matrix, localisation sequences for the plasma membrane, localisation sequences for the Golgi apparatus, the nucleus, the cytoplasm and the cytosceleton, etc.", "Such a signal peptide, localization signal or sequence or nuclear localization signal may be used for the transport of any of the herein defined nucleic acids, preferably an RNA or a DNA, more preferably an shRNA or a pDNA, e.g.", "into the nucleus.", "Without being limited thereto, such a signal peptide, localization signal or sequence or nuclear localization signal may comprise, e.g., localisation sequences for the endoplasmic reticulum.", "Particular localization signals or sequences or nuclear localization signals may include e.g.", "KDEL (SEQ ID NO: 326), DDEL (SEQ ID NO: 327), DEEL (SEQ ID NO: 328), QEDL (SEQ ID NO: 329), RDEL (SEQ ID NO: 330), and GQNLSTSN (SEQ ID NO: 331), nuclear localisation sequences, including PKKKRKV (SEQ ID NO: 332), PQKKIKS (SEQ ID NO: 333), QPKKP (SEQ ID NO: 334), RKKR (SEQ ID NO: 335), RKKRRQRRRAHQ (SEQ ID NO: 336), RQARRNRRRRWRERQR (SEQ ID NO: 337), MPLTRRRPAASQALAPPTP (SEQ ID NO: 338), GAALTILV (SEQ ID NO: 339), and GAALTLLG (SEQ ID NO: 340), localisation sequences for the endosomal compartiment, including MDDQRDLISNNEQLP (SEQ ID NO: 341), localisation sequences for the mitochondrial matrix, including MLFNLRXXLNNAAFRHGHNFMVRNFRCGQPLX (SEQ ID NO: 342), localisation sequences for the plasma membrane: GCVCSSNP (SEQ ID NO: 343), GQTVTTPL (SEQ ID NO: 344), GQELSQHE (SEQ ID NO: 345), GNSPSYNP (SEQ ID NO: 346), GVSGSKGQ (SEQ ID NO: 347), GQTITTPL (SEQ ID NO: 348), GQTLTTPL (SEQ ID NO: 349), GQIFSRSA (SEQ ID NO: 350), GQIHGLSP (SEQ ID NO: 351), GARASVLS (SEQ ID NO: 352), and GCTLSAEE (SEQ ID NO: 353), localisation sequences for the endoplasmic reticulum and the nucleus, including GAQVSSQK (SEQ ID NO: 354), and GAQLSRNT (SEQ ID NO: 355), localisation sequences for the Golgi apparatus, the nucleus, the cytoplasm and the cytosceleton, including GNAAAAKK (SEQ ID NO: 356), localisation sequences for the cytoplasm and cytosceleton, including GNEASYPL (SEQ ID NO: 357), localisation sequences for the plasma membrane and cytosceleton, including GSSKSKPK (SEQ ID NO: 358), etc.", "Examples of secretory signal peptide sequences as defined herein include, without being limited thereto, signal sequences of classical or non-classical MHC-molecules (e.g.", "signal sequences of MHC I and II molecules, e.g.", "of the MHC class I molecule HLA-A*0201), signal sequences of cytokines or immunoglobulines as defined herein, signal sequences of the invariant chain of immunoglobulines or antibodies as defined herein, signal sequences of Lamp1, Tapasin, Erp57, Calretikulin, Calnexin, and further membrane associated proteins or of proteins associated with the endoplasmic reticulum (ER) or the endosomal-lysosomal compartiment.", "Particularly preferably, signal sequences of MHC class I molecule HLA-A*0201 may be used according to the present invention.", "Most preferably such an additional component may occur as component L as defined herein.", "Alternatively, such an additional component may also be bound e.g.", "to a component L, P1, P2, P3 or (AA)x as defined herein, e.g.", "to a side chain of any of components L, P1, P2, P3 or (AA)x, preferably via a side chain of component P2, or optionally as a linker between components L and P1 or P3 and L. The binding to any of components L, P1, P2, or P3 may also be accomplished using an acid-labile bond, preferably via a side chain of any of components L, P1, P2, P3, which allows to detach or release the additional component at lower pH-values, e.g.", "at physiological pH-values as defined herein.", "Additionally, the inventive polymeric carrier according to formula (I) above (or according to any of its subformulas herein), may comprise further functional peptides or proteins preferably as ligand or amino acid component (AA)x, which may modulate the functionality of the inventive polymeric carrier accordingly.", "According to one alternative, such further functional peptides or proteins may comprise so called cell penetrating peptides (CPPs) or cationic peptides for transportation.", "Particularly preferred are CPPs, which induce a pH-mediated conformational change in the endosome and lead to an improved release of the inventive polymeric carrier (in complex with a nucleic acid) from the endosome by insertion into the lipid layer of the liposome.", "Such called cell penetrating peptides (CPPs) or cationic peptides for transportation, may include, without being limited thereto protamine, nucleoline, spermine or spermidine, poly-L-lysine (PLL), basic polypeptides, poly-arginine, cell penetrating peptides (CPPs), chimeric CPPs, such as Transportan, or MPG peptides, HIV-binding peptides, Tat, HIV-1 Tat (HIV), Tat-derived peptides, oligoarginines, members of the penetratin family, e.g.", "Penetratin, Antennapedia-derived peptides (particularly from Drosophila antennapedia), pAntp, pIsI, etc., antimicrobial-derived CPPs e.g.", "Buforin-2, Bac715-24, SynB, SynB(1), pVEC, hCT-derived peptides, SAP, MAP, KALA, PpTG20, Proline-rich peptides, Loligomers, Arginine-rich peptides, Calcitonin-peptides, FGF, Lactoferrin, poly-L-Lysine, poly-Arginine, histones, VP22 derived or analog peptides, HSV, VP22 (Herpes simplex), MAP, KALA or protein transduction domains (PTDs, PpT620, prolin-rich peptides, arginine-rich peptides, lysine-rich peptides, Pep-1, L-oligomers, Calcitonin peptide(s), etc.", "Likewise, such an additional component may occur as component L or (AA)x as defined herein.", "Alternatively, such an additional component may also be bound to a component L, P1, P2, P3 or (AA)x as defined herein, e.g.", "to a side chain of any of components L, P1, P2, P3, or (AA)x preferably via a side chain of component P2, or optionally as a linker between components L and P1 or P3 and L. The binding to any of components L, P1, P2, P3 or (AA)x may also be accomplished using an acid-labile bond, preferably via a side chain of any of components L, P1, P2, P3, or (AA)x which allows to detach or release the additional component at lower pH-values, e.g.", "at physiological pH-values as defined herein.", "In this context it is particularly preferred that this additional component occurs as ligand L or as amino acid component (AA)x of the repetitive component [S—P2—S]n of formula (I).", "According to a last alternative, the inventive polymeric carrier according to formula (I) above (or according to any of its subformulas herein), may comprise as an additional component, preferably as amino acid component (AA)x, any peptide or protein which can execute any favorable function in the cell.", "Particularly preferred are peptides or proteins selected from therapeutically active proteins or peptides, from antigens, e.g.", "tumour antigens, pathogenic antigens (animal antigens, viral antigens, protozoal antigens, bacterial antigens, allergic antigens), autoimmune antigens, or further antigens, from allergens, from antibodies, from immunostimulatory proteins or peptides, from antigen-specific T-cell receptors, or from any other protein or peptide suitable for a specific (therapeutic) application as defined below for coding nucleic acids.", "Particularly preferred are peptide epitopes from antigens as defined herein.", "Likewise, such an additional component may occur preferably as (AA)x as defined herein.", "Alternatively, such an additional component may also be bound to a component L, P1, P2, P3 or (AA)x as defined herein, e.g.", "to a side chain of any of components L, P1, P2, P3, or (AA)x preferably via a side chain of component P2, or optionally as a linker between components L and P1 or P3 and L. The binding to any of components L, P1, P2, P3 or (AA)x may also be accomplished using an acid-labile bond, preferably via a side chain of any of components L, P1, P2, P3, or (AA)x which allows to detach or release the additional component at lower pH-values, e.g.", "at physiological pH-values as defined herein.", "In this context it is particularly preferred that this additional component occurs as amino acid component (AA)x of the repetitive component [S—P2—S]n of formula (I).", "The inventive polymeric carrier according to formula (I) may comprise at least one of the above mentioned cationic or polycationic peptides, proteins or polymers or further components, e.g.", "(AA)x wherein any of the above alternatives may be combined with each other, and may be formed by polymerizing same in a polymerization condensation reaction via their —SH-moieties.", "The object underlying the present invention is furthermore solved according to a second embodiment of the present invention by the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) L-P1—S—[S—P2—S]n—S—P3-L as defined herein (or according to any of its subformulas as defined herein).", "This complex may also be termed “complexed nucleic acid” for the purposes of the present application.", "In the inventive polymeric carrier cargo complex, the polymeric carrier molecule according to generic formula (I) L-P1—S—[S—P2—S]n—S—P3-L as defined herein (or according to any of its subformulas herein) and the nucleic acid cargo are typically provided in a molar ratio of about 5 to 10000, preferably in a molar ratio of about 5 to 5000, more preferably in a molar ratio of about 5 to 2500, even more preferably in a molar ratio of about 5 to 2000, and most preferably in a molar ratio of about 5 to 1000 of inventive polymeric carrier molecule:nucleic acid, or in a molar ratio of about 50 to 1000 of inventive polymeric carrier molecule:nucleic acid, e.g.", "in a molar ratio of about 10 to 5000, in a molar ratio of about 20 to 2500, in a molar ratio of about 25 to 2000 of inventive polymeric carrier molecule:nucleic acid.", "Furthermore, in the inventive polymeric carrier cargo complex, the polymeric carrier molecule according to generic formula (I) L-P1—S—[S—P2—S]n—S—P3-L as defined herein (or according to any of its subformulas herein) and the nucleic acid cargo are preferably provided in an N/P-ratio of about 0.1 to 20, preferably in an N/P-ratio of about 0.2 to 12, and even more preferably in an N/P-ratio of about 0.4 to 10 or 0.6 to 5.In this context, an N/P-ratio is defined as the nitrogen/phosphate ratio (N/P-ratio) of the entire inventive polymeric carrier cargo complex.", "This is typically illustrative for the content/amount of peptides, if peptides are used, in the inventive polymeric carrier and characteristic for the content/amount of nucleic acids bound or complexed in the inventive polymeric carrier cargo complex.", "It may be calculated on the basis that, for example, 1 μg RNA typically contains about 3 nmol phosphate residues, provided that the RNA exhibits a statistical distribution of bases.", "Additionally, 1 μg peptide typically contains about x*1 μg/M(peptide) nmol nitrogen residues, dependent on the molecular weight and the number x of its (cationic) amino acids.", "In the context of the present invention such a nucleic acid cargo of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) (or according to any of its subformulas herein) may be any suitable nucleic acid, selected e.g.", "from any DNA, preferably, without being limited thereto, e.g.", "genomic DNA, single-stranded DNA molecules, double-stranded DNA molecules, coding DNA, DNA primers, DNA probes, a pDNA, immunostimulating DNA or may be selected e.g.", "from any PNA (peptide nucleic acid) or may be selected e.g.", "from any RNA, preferably, without being limited thereto, a coding RNA, a messenger RNA (mRNA), an siRNA, an shRNA, an antisense RNA, or riboswitches, immunostimulating RNA (isRNA) ribozymes or aptamers; etc.", "The nucleic acid may also be a ribosomal RNA (rRNA), a transfer RNA (tRNA), a messenger RNA (mRNA), or a viral RNA (vRNA).", "Preferably, the nucleic acid is RNA, more preferably a coding RNA.", "Even more preferably, the nucleic acid may be a (linear) single-stranded RNA, even more preferably an mRNA.", "In the context of the present invention, an mRNA is typically an RNA, which is composed of several structural elements, e.g.", "an optional 5′-UTR region, an upstream positioned ribosomal binding site followed by a coding region, an optional 3′-UTR region, which may be followed by a poly-A tail (and/or a poly-C-tail).", "An mRNA may occur as a mono-, di-, or even multicistronic RNA, i.e.", "an RNA which carries the coding sequences of one, two or more (identical or different) proteins or peptides as defined herein.", "Such coding sequences in di-, or even multicistronic mRNA may be separated by at least one IRES (internal ribosomal entry site) sequence.", "Furthermore, the nucleic acid of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) (or according to any of its subformulas herein) may be a single- or a double-stranded nucleic acid (molecule) (which may also be regarded as a nucleic acid (molecule) due to non-covalent association of two single-stranded nucleic acid(s) (molecules)) or a partially double-stranded or partially single stranded nucleic acid, which are at least partially self complementary (both of these partially double-stranded or partially single stranded nucleic acid molecules are typically formed by a longer and a shorter single-stranded nucleic acid molecule or by two single stranded nucleic acid molecules, which are about equal in length, wherein one single-stranded nucleic acid molecule is in part complementary to the other single-stranded nucleic acid molecule and both thus form a double-stranded nucleic acid molecule in this region, i.e.", "a partially double-stranded or partially single stranded nucleic acid (molecule).", "Preferably, the nucleic acid (molecule) may be a single-stranded nucleic acid molecule.", "Furthermore, the nucleic acid (molecule) may be a circular or linear nucleic acid molecule, preferably a linear nucleic acid molecule.", "Coding Nucleic Acids: The nucleic acid molecule of the inventive polymeric carrier cargo complex may encode a protein or a peptide, which may be selected, without being restricted thereto, e.g.", "from therapeutically active proteins or peptides, selected e.g, from adjuvant proteins, from antigens, e.g.", "tumour antigens, pathogenic antigens (e.g.", "selected, from animal antigens, from viral antigens, from protozoal antigens, from bacterial antigens), allergenic antigens, autoimmune antigens, or further antigens, from allergens, from antibodies, from immunostimulatory proteins or peptides, from antigen-specific T-cell receptors, or from any other protein or peptide suitable for a specific (therapeutic) application, wherein the coding nucleic acid may be transported into a cell, a tissue or an organism and the protein may be expressed subsequently in this cell, tissue or organism.", "The coding region of the nucleic acid molecule of the inventive polymeric carrier cargo complex may occur as a mono-, di-, or even multicistronic nucleic acid, i.e.", "a nucleic acid which carries the coding sequences of one, two or more proteins or peptides.", "Such coding sequences in di-, or even multicistronic nucleic acids may be separated by at least one internal ribosome entry site (IRES) sequence, or by signal peptides which induce the cleavage of the resulting polypeptide which comprises several proteins or peptides.", "In particular preferred aspects the encoded peptides or proteins are selected from human, viral, bacterial, protozoan proteins or peptides.", "a) Therapeutically Active Proteins In the context of the present invention, therapeutically active proteins or peptides may be encoded by the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex.", "Therapeutically active proteins are defined herein as proteins which have an effect on healing, prevent prophylactically or treat therapeutically a disease, preferably as defined herein, or are proteins of which an individual is in need of.", "These may be selected from any naturally or synthetically designed occurring recombinant or isolated protein known to a skilled person from the prior art.", "Without being restricted thereto therapeutically active proteins may comprise proteins, capable of stimulating or inhibiting the signal transduction in the cell, e.g.", "cytokines, lymphokines, monokines, growth factors, receptors, signal transduction molecules, transcription factors, etc; anticoagulants; antithrombins; antiallergic proteins; apoptotic factors or apoptosis related proteins, therapeutic active enzymes and any protein connected with any acquired disease or any hereditary disease.", "A therapeutically active protein, which may be encoded by the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex, may also be an adjuvant protein.", "In this context, an adjuvant protein is preferably to be understood as any protein, which is capable to elicit an innate immune response as defined herein.", "Preferably, such an innate immune response comprises activation of a pattern recognition receptor, such as e.g.", "a receptor selected from the Toll-like receptor (TLR) family, including e.g.", "a Toll like receptor selected from human TLR1 to TLR10 or from murine Toll like receptors TLR1 to TLR13.More preferably, the adjuvant protein is selected from human adjuvant proteins or from pathogenic adjuvant proteins, selected from the group consisting of, without being limited thereto, bacterial proteins, protozoan proteins, viral proteins, or fungal proteins, animal proteins, in particular from bacterial adjuvant proteins.", "In addition, nucleic acids encoding human proteins involved in adjuvant effects (e.g.", "ligands of pattern recognition receptors, pattern recognition receptors, proteins of the signal transduction pathways, transcription factors or cytokines) may be used as well.", "b) Antigens The nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex may alternatively encode an antigen.", "According to the present invention, the term “antigen” refers to a substance which is recognized by the immune system and is capable of triggering an antigen-specific immune response, e.g.", "by formation of antibodies or antigen-specific T-cells as part of an adaptive immune response.", "In this context an antigenic epitope, fragment or peptide of a protein means particularly B cell and T cell epitopes which may be recognized by B cells, antibodies or T cells respectively.", "In the context of the present invention, antigens as encoded by the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex typically comprise any antigen, antigenic epitope or antigenic peptide, falling under the above definition, more preferably protein and peptide antigens, e.g.", "tumour antigens, allergenic antigens, auto-immune self-antigens, pathogenic antigens, etc.", "In particular antigens as encoded by the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex may be antigens generated outside the cell, more typically antigens not derived from the host organism (e.g.", "a human) itself (i.e.", "non-self antigens) but rather derived from host cells outside the host organism, e.g.", "viral antigens, bacterial antigens, fungal antigens, protozoological antigens, animal antigens, allergenic antigens, etc.", "Allergenic antigens (allergy antigens) are typically antigens, which cause an allergy in a human and may be derived from either a human or other sources.", "Additionally, antigens as encoded by the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex may be furthermore antigens generated inside the cell, the tissue or the body.", "Such antigens include antigens derived from the host organism (e.g.", "a human) itself, e.g.", "tumour antigens, self-antigens or auto-antigens, such as auto-immune self-antigens, etc., but also (non-self) antigens as defined herein, which have been originally been derived from host cells outside the host organism, but which are fragmented or degraded inside the body, tissue or cell, e.g.", "by (protease) degradation, metabolism, etc.", "One class of antigens as encoded by the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex comprises tumour antigens.", "“Tumour antigens” are preferably located on the surface of the (tumour) cell.", "Tumour antigens may also be selected from proteins, which are overexpressed in tumour cells compared to a normal cell.", "Furthermore, tumour antigens also include antigens expressed in cells which are (were) not themselves (or originally not themselves) degenerated but are associated with the supposed tumour.", "Antigens which are connected with tumour-supplying vessels or (re)formation thereof, in particular those antigens which are associated with neovascularization, e.g.", "growth factors, such as VEGF, bFGF etc., are also included herein.", "Antigens connected with a tumour furthermore include antigens from cells or tissues, typically embedding the tumour.", "Further, some substances (usually proteins or peptides) are expressed in patients suffering (knowingly or not-knowingly) from a cancer disease and they occur in increased concentrations in the body fluids of said patients.", "These substances are also referred to as “tumour antigens”, however they are not antigens in the stringent meaning of an immune response inducing substance.", "The class of tumour antigens can be divided further into tumour-specific antigens (TSAs) and tumour-associated-antigens (TAAs).", "TSAs can only be presented by tumour cells and never by normal “healthy” cells.", "They typically result from a tumour specific mutation.", "TAAs, which are more common, are usually presented by both tumour and healthy cells.", "These antigens are recognized and the antigen-presenting cell can be destroyed by cytotoxic T cells.", "Additionally, tumour antigens can also occur on the surface of the tumour in the form of, e.g., a mutated receptor.", "In this case, they can be recognized by antibodies.", "According to a preferred aspect, such tumor antigens as encoded by the nucleic acid of the inventive polymeric carrier cargo complex are selected from the group consisting of 5T4, 707-AP, 9D7, AFP, AlbZIP HPG1, alpha-5-beta-1-integrin, alpha-5-beta-6-integrin, alpha-actinin-4/m, alpha-methylacyl-coenzyme A racemase, ART-4, ARTC1/m, B7H4, BAGE-1, BCL-2, bcr/abl, beta-catenin/m, BING-4, BRCA1/m, BRCA2/m, CA 15-3/CA 27-29, CA 19-9, CA72-4, CA125, calreticulin, CAMEL, CASP-8/m, cathepsin B, cathepsin L, CD19, CD20, CD22, CD25, CDE30, CD33, CD4, CD52, CD55, CD56, CD80, CDC27/m, CDK4/m, CDKN2A/m, CEA, CLCA2, CML28, CML66, COA-1/m, coactosin-like protein, collage XXIII, COX-2, CT-9/BRD6, Cten, cyclin B1, cyclin D1, cyp-B, CYPB1, DAM-10, DAM-6, DEK-CAN, EFTUD2/m, EGFR, ELF2/m, EMMPRIN, EpCam, EphA2, EphA3, ErbB3, ETV6-AML1, EZH2, FGF-5, FN, Frau-1, G250, GAGE-1, GAGE-2, GAGE-3, GAGE-4, GAGE-5, GAGE-6, GAGE7b, GAGE-8, GDEP, GnT-V, gp100, GPC3, GPNMB/m, HAGE, HAST-2, hepsin, Her2/neu, HERV-K-MEL, HLA-A*0201-R171, HLA-A11/m, HLA-A2/m, HNE, homeobox NKX3.1, HOM-TES-14/SCP-1, HOM-TES-85, HPV-E6, HPV-E7, HSP70-2M, HST-2, hTERT, iCE, IGF-1R, IL-13Ra2, IL-2R, IL-5, immature laminin receptor, kallikrein-2, kallikrein-4, Ki67, KIAA0205, KIAA0205/m, KK-LC-1, K-Ras/m, LAGE-A1, LDLR-FUT, MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-A6, MAGE-A9, MAGE-A10, MAGE-A12, MAGE-B1, MAGE-B2, MAGE-B3, MAGE-B4, MAGE-B5, MAGE-B6, MAGE-B10, MAGE-B16, MAGE-B17, MAGE-C1, MAGE-C2, MAGE-C3, MAGE-D1, MAGE-D2, MAGE-D4, MAGE-E1, MAGE-E2, MAGE-F1, MAGE-H1, MAGEL2, mammaglobin A, MART-1/melan-A, MART-2, MART-2/m, matrix protein 22, MC1R, M-CSF, ME1/m, mesothelin, MG50/PXDN, MMP11, MN/CA IX-antigen, MRP-3, MUC-1, MUC-2, MUM-1/m, MUM-2/m, MUM-3/m, myosin class I/m, NA88-A, N-acetylglucosaminyltransferase-V, Neo-PAP, Neo-PAP/m, NFYC/m, NGEP, NMP22, NPM/ALK, N-Ras/m, NSE, NY-ESO-1, NY-ESO-B, OA1, OFA-iLRP, OGT, OGT/m, OS-9, OS-9/m, osteocalcin, osteopontin, p15, p190 minor bcr-abl, p53, p53/m, PAGE-4, PAI-1, PAI-2, PART-1, PATE, PDEF, Pim-1-Kinase, Pin-1, Pml/PARalpha, POTE, PRAME, PRDX5/m, prostein, proteinase-3, PSA, PSCA, PSGR, PSM, PSMA, PTPRK/m, RAGE-1, RBAF600/m, RHAMM/CD168, RU1, RU2, S-100, SAGE, SART-1, SART-2, SART-3, SCC, SIRT2/m, Sp17, SSX-1, SSX-2/HOM-MEL-40, SSX-4, STAMP-1, STEAP, survivin, survivin-2B, SYT-SSX-1, SYT-SSX-2, TA-90, TAG-72, TARP, TEL-AML1, TGFbeta, TGFbetaRII, TGM-4, TPI/m, TRAG-3, TRG, TRP-1, TRP-2/6b, TRP/INT2, TRP-p8, tyrosinase, UPA, VEGF, VEGFR-2/FLK-1, and WT1, or a fragment, variant or epitope thereof.", "Epitopes typically comprise 5 to 15, preferably 5 to 12, more preferably 6 to 9 amino acids of the antigen, preferably in its native form.", "According to another alternative, one further class of antigens as encoded by the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex comprises allergenic antigens.", "Such allergenic antigens may be selected from antigens derived from different sources, e.g.", "from animals, plants, fungi, bacteria, etc.", "Allergens in this context include e.g.", "grasses, pollens, molds, drugs, or numerous environmental triggers, etc.", "Allergenic antigens typically belong to different classes of compounds, such as nucleic acids and their fragments, proteins or peptides and their fragments, carbohydrates, polysaccharides, sugars, lipids, phospholipids, etc.", "Of particular interest in the context of the present invention are antigens, which may be encoded by the nucleic acid molecule of the inventive polymeric carrier cargo complex, i.e.", "protein or peptide antigens and their fragments or epitopes, or nucleic acids and their fragments, particularly nucleic acids and their fragments, encoding such protein or peptide antigens and their fragments or epitopes.", "c) Antibodies According to a further alternative, the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex may encode an antibody or an antibody fragment.", "According to the present invention, such an antibody may be selected from any antibody, e.g.", "any recombinantly produced or naturally occurring antibodies, known in the art, in particular antibodies suitable for therapeutic, diagnostic or scientific purposes, or antibodies which have been identified in relation to specific cancer diseases.", "Herein, the term “antibody” is used in its broadest sense and specifically covers monoclonal and polyclonal antibodies (including agonist, antagonist, and blocking or neutralizing antibodies) and antibody species with polyepitopic specificity.", "According to the invention, the term “antibody” typically comprises any antibody known in the art (e.g.", "IgM, IgD, IgG, IgA and IgE antibodies), such as naturally occurring antibodies, antibodies generated by immunization in a host organism, antibodies which were isolated and identified from naturally occurring antibodies or antibodies generated by immunization in a host organism and recombinantly produced by biomolecular methods known in the art, as well as chimeric antibodies, human antibodies, humanized antibodies, bispecific antibodies, intrabodies, i.e.", "antibodies expressed in cells and optionally localized in specific cell compartments, and fragments and variants of the aforementioned antibodies.", "In general, an antibody consists of a light chain and a heavy chain both having variable and constant domains.", "The light chain consists of an N-terminal variable domain, V1, and a C-terminal constant domain, CL.", "In contrast, the heavy chain of the IgG antibody, for example, is comprised of an N-terminal variable domain, VH, and three constant domains, CH1, CH2 und CH3.In the context of the present invention, antibodies as encoded by the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex may preferably comprise full-length antibodies, i.e.", "antibodies composed of the full heavy and full light chains, as described above.", "However, derivatives of antibodies such as antibody fragments, variants or adducts may also be encoded by the nucleic acid molecule of the herein defined inventive inventive polymeric carrier cargo complex.", "Antibody fragments are preferably selected from Fab, Fab′, F(ab′)2, Fc, Facb, pFc′, Fd and Fv fragments of the aforementioned (full-length) antibodies.", "In general, antibody fragments are known in the art.", "For example, a Fab (“fragment, antigen binding”) fragment is composed of one constant and one variable domain of each of the heavy and the light chain.", "The two variable domains bind the epitope on specific antigens.", "The two chains are connected via a disulfide linkage.", "A scFv (“single chain variable fragment”) fragment, for example, typically consists of the variable domains of the light and heavy chains.", "The domains are linked by an artificial linkage, in general a polypeptide linkage such as a peptide composed of 15-25 glycine, proline and/or serine residues.", "In the present context it is preferable that the different chains of the antibody or antibody fragment are encoded by a multicistronic nucleic acid molecule.", "Alternatively, the different strains of the antibody or antibody fragment are encoded by several monocistronic nucleic acid(s) (sequences).", "siRNA: According to a further alternative, the nucleic acid of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) (or according to any of its subformulas herein) may be in the form of dsRNA, preferably siRNA.", "A dsRNA, or a siRNA, is of interest particularly in connection with the phenomenon of RNA interference.", "The in vitro technique of RNA interference (RNAi) is based on double-stranded RNA molecules (dsRNA), which trigger the sequence-specific suppression of gene expression (Zamore (2001) Nat.", "Struct.", "Biol.", "9: 746-750; Sharp (2001) Genes Dev.", "5:485-490: Hannon (2002) Nature 41: 244-251).", "In the transfection of mammalian cells with long dsRNA, the activation of protein kinase R and RnaseL brings about unspecific effects, such as, for example, an interferon response (Stark et al.", "(1998) Annu.", "Rev.", "Biochem.", "67: 227-264; He and Katze (2002) Viral Immunol.", "15: 95-119).", "These unspecific effects are avoided when shorter, for example 21- to 23-mer, so-called siRNA (small interfering RNA), is used, because unspecific effects are not triggered by siRNA that is shorter than 30 bp (Elbashir et al.", "(2001) Nature 411: 494-498).", "The nucleic acid of the inventive polymeric carrier cargo complex may thus be a double-stranded RNA (dsRNA) having a length of from 17 to 29, preferably from 19 to 25, and preferably being at least 90%, more preferably 95% and especially 100% (of the nucleotides of a dsRNA) complementary to a section of the nucleic acid sequence of a (therapeutically relevant) protein or antigen described (as active ingredient) hereinbefore, either a coding or a non-coding section, preferably a coding section.", "90% complementary means that with a length of a dsRNA described herein of, for example, 20 nucleotides, this contains not more than 2 nucleotides without corresponding complementarity with the corresponding section of the mRNA.", "The sequence of the double-stranded RNA used according to the invention as the nucleic acid of the inventive polymeric carrier cargo complex is, however, preferably wholly complementary in its general structure with a section of the nucleic acid of a therapeutically relevant protein or antigen described hereinbefore.", "In this context the nucleic acid of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) may be a dsRNA having the general structure 5′-(N17-29)-3′, preferably having the general structure 5′-(N19-25)-3′, more preferably having the general structure 5′-(N19-24)-3′, or yet more preferably having the general structure 5′-(N21-23)-3′, wherein for each general structure each N is a (preferably different) nucleotide of a section of the mRNA of a therapeutically relevant protein or antigen described hereinbefore, preferably being selected from a continuous number of 17 to 29 nucleotides of the mRNA of a therapeutically relevant protein or antigen and being present in the general structure 5′-(N17-29)-3′ in their natural order.", "In principle, all the sections having a length of from 17 to 29, preferably from 19 to 25, base pairs that occur in the coding region of the mRNA can serve as target sequence for a dsRNA herein.", "Equally, dsRNAs used as nucleic acid of the inventive polymeric carrier cargo complex can also be directed against nucleotide sequences of a (therapeutically relevant) protein or antigen described (as active ingredient) hereinbefore that do not lie in the coding region, in particular in the 5′ non-coding region of the mRNA, for example, therefore, against non-coding regions of the mRNA having a regulatory function.", "The target sequence of the dsRNA used as nucleic acid of the inventive polymeric carrier cargo complex can therefore lie in the translated and untranslated region of the mRNA and/or in the region of the control elements of a protein or antigen described hereinbefore.", "The target sequence of a dsRNA used as nucleic acid of the inventive polymeric carrier cargo complex can also lie in the overlapping region of untranslated and translated sequence; in particular, the target sequence can comprise at least one nucleotide upstream of the start triplet of the coding region of the mRNA.", "Immunostimulatory Nucleic Acids: a) Immunostimulatory CpG Nucleic Acids: According to another alternative, the nucleic acid of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) (or according to any of its subformulas herein) may be in the form of a a(n) (immunostimulatory) CpG nucleic acid, in particular CpG-RNA or CpG-DNA, which preferably induces an innate immune response.", "A CpG-RNA or CpG-DNA used according to the invention can be a single-stranded CpG-DNA (ss CpG-DNA), a double-stranded CpG-DNA (dsDNA), a single-stranded CpG-RNA (ss CpG-RNA) or a double-stranded CpG-RNA (ds CpG-RNA).", "The CpG nucleic acid used according to the invention is preferably in the form of CpG-RNA, more preferably in the form of single-stranded CpG-RNA (ss CpG-RNA).", "Also preferably, such CpG nucleic acids have a length as described above.", "Preferably the CpG motifs are unmethylated.", "b) Immunostimulatory RNA (isRNA): Likewise, according to a further alternative, the nucleic acid of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) (or according to any of its subformulas herein) may be in the form of a of an immunostimulatory RNA (isRNA), which preferably elicits an innate immune response.", "Such an immunostimulatory RNA may be any (double-stranded or single-stranded) RNA, e.g.", "a coding RNA, as defined herein.", "Preferably, the immunostimulatory RNA may be a single-stranded, a double-stranded or a partially double-stranded RNA, more preferably a single-stranded RNA, and/or a circular or linear RNA, more preferably a linear RNA.", "More preferably, the immunostimulatory RNA may be a (linear) single-stranded RNA.", "Even more preferably, the immunostimulatory RNA may be a (long) (linear) single-stranded) non-coding RNA.", "In this context it is particular preferred that the isRNA carries a triphosphate at its 5′-end which is the case for in vitro transcribed RNA.", "An immunostimulatory RNA may also occur as a short RNA oligonucleotide as defined herein.", "An immunostimulatory RNA as used herein may furthermore be selected from any class of RNA molecules, found in nature or being prepared synthetically, and which can induce an innate immune response and may support an adaptive immune response induced by an antigen.", "In this context, an immune response may occur in various ways.", "A substantial factor for a suitable (adaptive) immune response is the stimulation of different T-cell sub-populations.", "T-lymphocytes are typically divided into two sub-populations, the T-helper 1 (Th1) cells and the T-helper 2 (Th2) cells, with which the immune system is capable of destroying intracellular (Th1) and extracellular (Th2) pathogens (e.g.", "antigens).", "The two Th cell populations differ in the pattern of the effector proteins (cytokines) produced by them.", "Thus, Th1 cells assist the cellular immune response by activation of macrophages and cytotoxic T-cells.", "Th2 cells, on the other hand, promote the humoral immune response by stimulation of B-cells for conversion into plasma cells and by formation of antibodies (e.g.", "against antigens).", "The Th1/Th2 ratio is therefore of great importance in the induction and maintenance of an adaptive immune response.", "In connection with the present invention, the Th1/Th2 ratio of the (adaptive) immune response is preferably shifted in the direction towards the cellular response (Th1 response) and a cellular immune response is thereby induced.", "According to one example, the innate immune system which may support an adaptive immune response, may be activated by ligands of Toll-like receptors (TLRs).", "TLRs are a family of highly conserved pattern recognition receptor (PRR) polypeptides that recognize pathogen-associated molecular patterns (PAMPs) and play a critical role in innate immunity in mammals.", "Currently at least thirteen family members, designated TLR1-TLR13 (Toll-like receptors: TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12 or TLR13), have been identified.", "Furthermore, a number of specific TLR ligands have been identified.", "It was e.g.", "found that unmethylated bacterial DNA and synthetic analogs thereof (CpG DNA) are ligands for TLR9 (Hemmi H et a.", "(2000) Nature 408:740-5; Bauer S et al.", "(2001) Proc NatlAcadSci USA 98, 9237-42).", "Furthermore, it has been reported that ligands for certain TLRs include certain nucleic acid molecules and that certain types of RNA are immunostimulatory in a sequence-independent or sequence-dependent manner, wherein these various immunostimulatory RNAs may e.g.", "stimulate TLR3, TLR7, or TLR8, or intracellular receptors such as RIG-I, MDA-5, etc.", "E.g.", "Lipford et al.", "determined certain G,U-containing oligoribonucleotides as immunostimulatory by acting via TLR7 and TLR8 (see WO 03/086280).", "The immunostimulatory G,U-containing oligoribonucleotides described by Lipford et al.", "were believed to be derivable from RNA sources including ribosomal RNA, transfer RNA, messenger RNA, and viral RNA.", "The immunostimulatory RNA (isRNA) used as the nucleic acid molecule of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) (or according to any of its subformulas herein) may thus comprise any RNA sequence known to be immunostimulatory, including, without being limited thereto, RNA sequences representing and/or encoding ligands of TLRs, preferably selected from human family members TLR1-TLR10 or murine family members TLR1-TLR13, more preferably selected from (human) family members TLR1-TLR10, even more preferably from TLR7 and TLR8, ligands for intracellular receptors for RNA (such as RIG-I or MDA-5, etc.)", "(see e.g.", "Meylan, E., Tschopp, J.", "(2006).", "Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses.", "Mol.", "Cell 22, 561-569), or any other immunostimulatory RNA sequence.", "Furthermore, (classes of) immunostimulatory RNA molecules, used as the nucleic acid molecule of the inventive polymeric carrier cargo complex may include any other RNA capable of eliciting an immune response.", "Without being limited thereto, such an immunostimulatory RNA may include ribosomal RNA (rRNA), transfer RNA (tRNA), messenger RNA (mRNA), and viral RNA (vRNA).", "Such an immunostimulatory RNA may comprise a length of 1000 to 5000, of 500 to 5000, of 5 to 5000, or of 5 to 1000, 5 to 500, 5 to 250, of 5 to 100, of 5 to 50 or of 5 to 30 nucleotides.", "According to a particularly preferred aspect of this embodiment of the present invention, such immunostimulatory nucleic acid sequences particularly isRNA consist of or comprise a nucleic acid of formula (III) or (IV): GlXmGn, (formula (III)) wherein: G is guanosine, uracil or an analogue of guanosine or uracil; X is guanosine, uracil, adenosine, thymidine, cytosine or an analogue of the above-mentioned nucleotides; l is an integer from 1 to 40, wherein when l=1 G is guanosine or an analogue thereof, when l>1 at least 50% of the nucleotides are guanosine or an analogue thereof; m is an integer and is at least 3; wherein when m=3 X is uracil or an analogue thereof, when m>3 at least 3 successive uracils or analogues of uracil occur; n is an integer from 1 to 40, wherein when n=1 G is guanosine or an analogue thereof, when n>1 at least 50% of the nucleotides are guanosine or an analogue thereof.", "ClXmCn, (formula (IV)) wherein: C is cytosine, uracil or an analogue of cytosine or uracil; X is guanosine, uracil, adenosine, thymidine, cytosine or an analogue of the above-mentioned nucleotides; l is an integer from 1 to 40, wherein when l=1 C is cytosine or an analogue thereof, when l>1 at least 50% of the nucleotides are cytosine or an analogue thereof; m is an integer and is at least 3; wherein when m=3 X is uracil or an analogue thereof, when m>3 at least 3 successive uracils or analogues of uracil occur; n is an integer from 1 to 40, wherein when n=1 C is cytosine or an analogue thereof, when n>1 at least 50% of the nucleotides are cytosine or an analogue thereof.", "The nucleic acids of formula (III) or (IV), which may be used as the nucleic acid cargo of the inventive polymeric carrier cargo complex may be relatively short nucleic acid molecules with a typical length of approximately from 5 to 100 (but may also be longer than 100 nucleotides for specific embodiments, e.g.", "up to 200 nucleotides), from 5 to 90 or from 5 to 80 nucleotides, preferably a length of approximately from 5 to 70, more preferably a length of approximately from 8 to 60 and, more preferably a length of approximately from 15 to 60 nucleotides, more preferably from 20 to 60, most preferably from 30 to 60 nucleotides.", "If the nucleic acid of the inventive nucleic acid cargo complex has a maximum length of e.g.", "100 nucleotides, m will typically be <=98.The number of nucleotides G in the nucleic acid of formula (III) is determined by l or n. l and n, independently of one another, are each an integer from 1 to 40, wherein when l or n=1 G is guanosine or an analogue thereof, and when l or n>1 at least 50% of the nucleotides are guanosine or an analogue thereof.", "For example, without implying any limitation, when l or n=4 Gl or Gn can be, for example, a GUGU, GGUU, UGUG, UUGG, GUUG, GGGU, GGUG, GUGG, UGGG or GGGG, etc.", "; when l or n=5 Gl or Gn can be, for example, a GGGUU, GGUGU, GUGGU, UGGGU, UGGUG, UGUGG, UUGGG, GUGUG, GGGGU, GGGUG, GGUGG, GUGGG, UGGGG, or GGGGG, etc.", "; etc.", "A nucleotide adjacent to Xm in the nucleic acid of formula (III) according to the invention is preferably not a uracil.", "Similarly, the number of nucleotides C in the nucleic acid of formula (IV) according to the invention is determined by l or n. l and n, independently of one another, are each an integer from 1 to 40, wherein when l or n=1 C is cytosine or an analogue thereof, and when l or n>1 at least 50% of the nucleotides are cytosine or an analogue thereof.", "For example, without implying any limitation, when l or n=4, Cl or Cn can be, for example, a CUCU, CCUU, UCUC, UUCC, CUUC, CCCU, CCUC, CUCC, UCCC or CCCC, etc.", "; when l or n=5 Cl or Cn can be, for example, a CCCUU, CCUCU, CUCCU, UCCCU, UCCUC, UCUCC, UUCCC, CUCUC, CCCCU, CCCUC, CCUCC, CUCCC, UCCCC, or CCCCC, etc.", "; etc.", "A nucleotide adjacent to Xm in the nucleic acid of formula (IV) according to the invention is preferably not a uracil.", "Preferably, for formula (III), when l or n>1, at least 60%, 70%, 80%, 90% or even 100% of the nucleotides are guanosine or an analogue thereof, as defined above.", "The remaining nucleotides to 100% (when guanosine constitutes less than 100% of the nucleotides) in the flanking sequences Gl and/or Gn are uracil or an analogue thereof, as defined hereinbefore.", "Also preferably, l and n, independently of one another, are each an integer from 2 to 30, more preferably an integer from 2 to 20 and yet more preferably an integer from 2 to 15.The lower limit of l or n can be varied if necessary and is at least 1, preferably at least 2, more preferably at least 3, 4, 5, 6, 7, 8, 9 or 10.This definition applies correspondingly to formula (IV).", "According to a further particularly preferred aspect of this embodiment, such immunostimulatory nucleic acid sequences particularly isRNA consist of or comprise a nucleic acid of formula (V) or (VI): (NuGlXmGnNv)a, (formula (V)) wherein: G is guanosine (guanine), uridine (uracil) or an analogue of guanosine (guanine) or uridine (uracil), preferably guanosine (guanine) or an analogue thereof; X is guanosine (guanine), uridine (uracil), adenosine (adenine), thymidine (thymine), cytidine (cytosine), or an analogue of these nucleotides (nucleosides), preferably uridine (uracil) or an analogue thereof; N is a nucleic acid sequence having a length of about 4 to 50, preferably of about 4 to 40, more preferably of about 4 to 30 or 4 to 20 nucleic acids, each N independently being selected from guanosine (guanine), uridine (uracil), adenosine (adenine), thymidine (thymine), cytidine (cytosine) or an analogue of these nucleotides (nucleosides); a is an integer from 1 to 20, preferably from 1 to 15, most preferably from 1 to 10; l is an integer from 1 to 40, wherein when l=1, G is guanosine (guanine) or an analogue thereof, when l>1, at least 50% of these nucleotides (nucleosides) are guanosine (guanine) or an analogue thereof; m is an integer and is at least 3; wherein when m=3, X is uridine (uracil) or an analogue thereof, and when m>3, at least 3 successive uridines (uracils) or analogues of uridine (uracil) occur; n is an integer from 1 to 40, wherein when n=1, G is guanosine (guanine) or an analogue thereof, when n>1, at least 50% of these nucleotides (nucleosides) are guanosine (guanine) or an analogue thereof; u,v may be independently from each other an integer from 0 to 50, preferably wherein when u=0, v≥1, or when v=0, u≥1; wherein the nucleic acid molecule of formula (V) has a length of at least 50 nucleotides, preferably of at least 100 nucleotides, more preferably of at least 150 nucleotides, even more preferably of at least 200 nucleotides and most preferably of at least 250 nucleotides.", "(NuClXmCnNv)a (formula (VI)) wherein: C is cytidine (cytosine), uridine (uracil) or an analogue of cytidine (cytosine) or uridine (uracil), preferably cytidine (cytosine) or an analogue thereof; X is guanosine (guanine), uridine (uracil), adenosine (adenine), thymidine (thymine), cytidine (cytosine) or an analogue of the above-mentioned nucleotides (nucleosides), preferably uridine (uracil) or an analogue thereof; N is each a nucleic acid sequence having independent from each other a length of about 4 to 50, preferably of about 4 to 40, more preferably of about 4 to 30 or 4 to 20 nucleic acids, each N independently being selected from guanosine (guanine), uridine (uracil), adenosine (adenine), thymidine (thymine), cytidine (cytosine) or an analogue of these nucleotides (nucleosides); a is an integer from 1 to 20, preferably from 1 to 15, most preferably from 1 to 10; l is an integer from 1 to 40, wherein when l=1, C is cytidine (cytosine) or an analogue thereof, when l>1, at least 50% of these nucleotides (nucleosides) are cytidine (cytosine) or an analogue thereof; m is an integer and is at least 3; wherein when m=3, X is uridine (uracil) or an analogue thereof, when m>3, at least 3 successive uridines (uracils) or analogues of uridine (uracil) occur; n is an integer from 1 to 40, wherein when n=1, C is cytidine (cytosine) or an analogue thereof, when n>1, at least 50% of these nucleotides (nucleosides) are cytidine (cytosine) or an analogue thereof.", "u, v may be independently from each other an integer from 0 to 50, preferably wherein when u=0, v≥1, or when v=0, u≥1; wherein the nucleic acid molecule of formula (VI) according to the invention has a length of at least 50 nucleotides, preferably of at least 100 nucleotides, more preferably of at least 150 nucleotides, even more preferably of at least 200 nucleotides and most preferably of at least 250 nucleotides.", "For formula (VI), any of the definitions given above for elements N (i.e.", "Nu and Nv) and X (Xm), particularly the core structure as defined above, as well as for integers a, l, m, n, u and v, similarly apply to elements of formula (V) correspondingly, wherein in formula (VI) the core structure is defined by ClXmCn.", "The definition of bordering elements Nu and Nv is identical to the definitions given above for Nu and Nv.", "According to a very particularly preferred aspect of this embodiment, the inventive nucleic acid molecule according to formula (V) may be selected from e.g.", "any of the following sequences: (SEQ ID NO: 359) UAGCGAAGCUCUUGGACCUAGGUUUUUUUUUUUUUUUGGGUGCGUUCCUA GAAGUACACG (SEQ ID NO: 360) UAGCGAAGCUCUUGGACCUAGGUUUUUUUUUUUUUUUGGGUGCGUUCCUA GAAGUACACGAUCGCUUCGAGAACCUGGAUCCAAAAAAAAAAAAAAACCC ACGCAAGGAUCUUCAUGUGC (SEQ ID NO: 361) GGGAGAAAGCUCAAGCUUGGAGCAAUGCCCGCACAUUGAGGAAACCGAGU UGCAUAUCUCAGAGUAUUGGCCCCCGUGUAGGUUAUUCUUGACAGACAGU GGAGCUUAUUCACUCCCAGGAUCCGAGUCGCAUACUACGGUACUGGUGAC AGACCUAGGUCGUCAGUUGACCAGUCCGCCACUAGACGUGAGUCCGUCAA AGCAGUUAGAUGUUACACUCUAUUAGAUC (SEQ ID NO: 362) GGGAGAAAGCUCAAGCUUGGAGCAAUGCCCGCACAUUGAGGAAACCGAGU UGCAUAUCUCAGAGUAUUGGCCCCCGUGUAGGUUAUUCUUGACAGACAGU GGAGCUUAUUCACUCCCAGGAUCCGAGUCGCAUACUACGGUACUGGUGAC AGACCUAGGUCGUCAGUUGACCAGUCCGCCACUAGACGUGAGUCCGUCAA AGCAGUUAGAUGUUACACUCUAUUAGAUCUCGGAUUACAGCUGGAAGGAG CAGGAGUAGUGUUCUUGCUCUAAGUACCGAGUGUGCCCAAUACCCGAUCA GCUUAUUAACGAACGGCUCCUCCUCUUAGACUGCAGCGUAAGUGCGGAAU CUGGGGAUCAAAUUACUGACUGCCUGGAUUACCCUCGGACAUAUAACCUU GUAGCACGCUGUUGCUGUAUAGGUGACCAACGCCCACUCGAGUAGACCAG CUCUCUUAGUCCGGACAAUGAUAGGAGGCGCGGUCAAUCUACUUCUGGCU AGUUAAGAAUAGGCUGCACCGACCUCUAUAAGUAGCGUGUCCUCUAG (SEQ ID NO: 363) GGGAGAAAGCUCAAGCUUGGAGCAAUGCCCGCACAUUGAGGAAACCGAGU UGCAUAUCUCAGAGUAUUGGCCCCCGUGUAGGUUAUUCUUGACAGACAGU GGAGCUUAUUCACUCCCAGGAUCCGAGUCGCAUACUACGGUACUGGUGAC AGACCUAGGUCGUCAGUUGACCAGUCCGCCACUAGACGUGAGUCCGUCAA AGCAGUUAGAUGUUACACUCUAUUAGAUCUCGGAUUACAGCUGGAAGGAG CAGGAGUAGUGUUCUUGCUCUAAGUACCGAGUGUGCCCAAUACCCGAUCA GCUUAUUAACGAACGGCUCCUCCUCUUAGACUGCAGCGUAAGUGCGGAAU CUGGGGAUCAAAUUACUGACUGCCUGGAUUACCCUCGGACAUAUAACCUU GUAGCACGCUGUUGCUGUAUAGGUGACCAACGCCCACUCGAGUAGACCAG CUCUCUUAGUCCGGACAAUGAUAGGAGGCGCGGUCAAUCUACUUCUGGCU AGUUAAGAAUAGGCUGCACCGACCUCUAUAAGUAGCGUGUCCUCUAGAGC UACGCAGGUUCGCAAUAAAAGCGUUGAUUAGUGUGCAUAGAACAGACCUC UUAUUCGGUGAAACGCCAGAAUGCUAAAUUCCAAUAACUCUUCCCAAAAC GCGUACGGCCGAAGACGCGCGCUUAUCUUGUGUACGUUCUCGCACAUGGA AGAAUCAGCGGGCAUGGUGGUAGGGCAAUAGGGGAGCUGGGUAGCAGCGA AAAAGGGCCCCUGCGCACGUAGCUUCGCUGUUCGUCUGAAACAACCCGGC AUCCGUUGUAGCGAUCCCGUUAUCAGUGUUAUUCUUGUGCGCACUAAGAU UCAUGGUGUAGUCGACAAUAACAGCGUCUUGGCAGAUUCUGGUCACGUGC CCUAUGCCCGGGCUUGUGCCUCUCAGGUGCACAGCGAUACUUAAAGCCUU CAAGGUACUCGACGUGGGUACCGAUUCGUGACACUUCCUAAGAUUAUUCC ACUGUGUUAGCCCCGCACCGCCGACCUAAACUGGUCCAAUGUAUACGCAU UCGCUGAGCGGAUCGAUAAUAAAAGCUUGAAUU (SEQ ID NO: 364) GGGAGAAAGCUCAAGCUUAUCCAAGUAGGCUGGUCACCUGUACAACGUAG CCGGUAUUUUUUUUUUUUUUUUUUUUUUGACCGUCUCAAGGUCCAAGUUA GUCUGCCUAUAAAGGUGCGGAUCCACAGCUGAUGAAAGACUUGUGCGGUA CGGUUAAUCUCCCCUUUUUUUUUUUUUUUUUUUUUAGUAAAUGCGUCUAC UGAAUCCAGCGAUGAUGCUGGCCCAGAUC (R 722 SEQ ID NO: 365) GGGAGAAAGCUCAAGCUUAUCCAAGUAGGCUGGUCACCUGUACAACGUAG CCGGUAUUUUUUUUUUUUUUUUUUUUUUGACCGUCUCAAGGUCCAAGUUA GUCUGCCUAUAAAGGUGCGGAUCCACAGCUGAUGAAAGACUUGUGCGGUA CGGUUAAUCUCCCCUUUUUUUUUUUUUUUUUUUUUAGUAAAUGCGUCUAC UGAAUCCAGCGAUGAUGCUGGCCCAGAUCUUCGACCACAAGUGCAUAUAG UAGUCAUCGAGGGUCGCCUUUUUUUUUUUUUUUUUUUUUUUGGCCCAGUU CUGAGACUUCGCUAGAGACUACAGUUACAGCUGCAGUAGUAACCACUGCG GCUAUUGCAGGAAAUCCCGUUCAGGUUUUUUUUUUUUUUUUUUUUUCCGC UCACUAUGAUUAAGAACCAGGUGGAGUGUCACUGCUCUCGAGGUCUCACG AGAGCGCUCGAUACAGUCCUUGGAAGAAUCUUUUUUUUUUUUUUUUUUUU UUGUGCGACGAUCACAGAGAACUUCUAUUCAUGCAGGUCUGCUCUA (SEQ ID NO: 366) GGGAGAAAGCUCAAGCUUAUCCAAGUAGGCUGGUCACCUGUACAACGUAG CCGGUAUUUUUUUUUUUUUUUUUUUUUUGACCGUCUCAAGGUCCAAGUUA GUCUGCCUAUAAAGGUGCGGAUCCACAGCUGAUGAAAGACUUGUGCGGUA CGGUUAAUCUCCCCUUUUUUUUUUUUUUUUUUUUUAGUAAAUGCGUCUAC UGAAUCCAGCGAUGAUGCUGGCCCAGAUCUUCGACCACAAGUGCAUAUAG UAGUCAUCGAGGGUCGCCUUUUUUUUUUUUUUUUUUUUUUUGGCCCAGUU CUGAGACUUCGCUAGAGACUACAGUUACAGCUGCAGUAGUAACCACUGCG GCUAUUGCAGGAAAUCCCGUUCAGGUUUUUUUUUUUUUUUUUUUUUCCGC UCACUAUGAUUAAGAACCAGGUGGAGUGUCACUGCUCUCGAGGUCUCACG AGAGCGCUCGAUACAGUCCUUGGAAGAAUCUUUUUUUUUUUUUUUUUUUU UUGUGCGACGAUCACAGAGAACUUCUAUUCAUGCAGGUCUGCUCUAGAAC GAACUGACCUGACGCCUGAACUUAUGAGCGUGCGUAUUUUUUUUUUUUUU UUUUUUUUUCCUCCCAACAAAUGUCGAUCAAUAGCUGGGCUGUUGGAGAC GCGUCAGCAAAUGCCGUGGCUCCAUAGGACGUGUAGACUUCUAUUUUUUU UUUUUUUUUUUUUUCCCGGGACCACAAAUAAUAUUCUUGCUUGGUUGGGC GCAAGGGCCCCGUAUCAGGUCAUAAACGGGUACAUGUUGCACAGGCUCCU UUUUUUUUUUUUUUUUUUUUUUCGCUGAGUUAUUCCGGUCUCAAAAGACG GCAGACGUCAGUCGACAACACGGUCUAAAGCAGUGCUACAAUCUGCCGUG UUCGUGUUUUUUUUUUUUUUUUUUUUGUGAACCUACACGGCGUGCACUGU AGUUCGCAAUUCAUAGGGUACCGGCUCAGAGUUAUGCCUUGGUUGAAAAC UGCCCAGCAUACUUUUUUUUUUUUUUUUUUUUCAUAUUCCCAUGCUAAGC AAGGGAUGCCGCGAGUCAUGUUAAGCUUGAAUU According to another very particularly preferred embodiment, the nucleic acid molecule according to formula (VI) may be selected from e.g.", "any of the following sequences: (SEQ ID NO: 367) UAGCGAAGCUCUUGGACCUACCUUUUUUUUUUUUUUCCCUGCGUUCCUAG AAGUACACG or (SEQ ID NO: 368) UAGCGAAGCUCUUGGACCUACCUUUUUUUUUUUUUUUCCCUGCGUUCCUA GAAGUACACGAUCGCUUCGAGAACCUGGAUGGAAAAAAAAAAAAAAAGGG ACGCAAGGAUCUUCAUGUGC In a further preferred embodiment the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex may also occur in the form of a modified nucleic acid.", "According to a further aspect, the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex may be provided as a “stabilized nucleic acid”, preferably as a stabilized RNA or DNA, more preferably as a RNA that is essentially resistant to in vivo degradation (e.g.", "by an exo- or endo-nuclease).", "In this context, the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex may contain backbone modifications, sugar modifications or base modifications.", "A backbone modification in connection with the present invention is a modification in which phosphates of the backbone of the nucleotides contained in the nucleic acid molecule of the inventive polymeric carrier cargo complex are chemically modified.", "A sugar modification in connection with the present invention is a chemical modification of the sugar of the nucleotides of the nucleic acid molecule of the inventive polymeric carrier cargo complex.", "Furthermore, a base modification in connection with the present invention is a chemical modification of the base moiety of the nucleotides of the nucleic acid molecule of the inventive polymeric carrier cargo complex.", "According to a further aspect, the nucleic acid molecule of the herein defined inventive polymeric carrier cargo complex can contain a lipid modification.", "The nucleic acid of the inventive polymeric carrier cargo complex as defined herein may also be in the form of a modified nucleic acid, wherein any modification, as defined herein, may be introduced into the nucleic acid.", "Modifications as defined herein preferably lead to a further stabilized nucleic acid.", "According to one aspect, the nucleic acid of the inventive polymeric carrier cargo complex as defined herein may thus be provided as a “stabilized nucleic acid”, preferably as a stabilized mRNA, more preferably as an mRNA that is essentially resistant to in vivo degradation (e.g.", "by an exo- or endo-nuclease).", "Such stabilization can be effected, for example, by a modified phosphate in which phosphates of the backbone of the nucleotides contained in the nucleic acid are chemically modified.", "The nucleic acid of the inventive polymeric carrier cargo complex may additionally or alternatively also contain sugar or base modifications.", "The nucleic acid of the inventive polymeric carrier cargo complex, particularly if provided as an mRNA, can also be stabilized against degradation by RNases by the addition of a so-called “5′ cap” structure.", "Particular preference is given in this connection to an m7G(5′)ppp (5′(A,G(5′)ppp(5′)A or G(5′)ppp(5′)G as the 5′ cap” structure.", "According to a further aspect, the nucleic acid of the inventive polymeric carrier cargo complex may contain, especially if the nucleic acid is in the form of an mRNA, a poly-A tail on the 3′ terminus of typically about 10 to 200 adenosine nucleotides, preferably about 10 to 100 adenosine nucleotides, more preferably about 20 to 100 adenosine nucleotides or even more preferably about 40 to 80 adenosine nucleotides.", "According to a further aspect, the nucleic acid of the inventive polymeric carrier cargo complex may contain, especially if the nucleic acid is in the form of an mRNA, a poly-C tail on the 3′ terminus of typically about 10 to 200 cytosine nucleotides, preferably about 10 to 100 cytosine nucleotides, more preferably about 20 to 70 cytosine nucleotides or even more preferably about 20 to 60 or even 10 to 40 cytosine nucleotides.", "According to another aspect, the nucleic acid of the inventive polymeric carrier cargo complex may be modified, and thus stabilized, especially if the nucleic acid is in the form of an mRNA, by modifying the G/C content of the nucleic acid, particularly an mRNA, preferably of the coding region thereof.", "In a particularly preferred aspect of the present invention, the G/C content of the coding region of the nucleic acid of the inventive polymeric carrier cargo complex, especially if the nucleic acid is in the form of an mRNA, is modified, particularly increased, compared to the G/C content of the coding region of its particular wild-type mRNA, i.e.", "the unmodified mRNA.", "The encoded amino acid sequence of the at least one mRNA is preferably not modified compared to the coded amino acid sequence of the particular wild-type mRNA.", "Preferably, the G/C content of the coding region of nucleic acid of the inventive polymeric carrier cargo complex, especially if the nucleic acid is in the form of an mRNA, is increased by at least 7%, more preferably by at least 15%, particularly preferably by at least 20%, compared to the G/C content of the coded region of the wild-type mRNA which codes for an antigen, antigenic protein or antigenic peptide as deinined herein or its fragment or variant thereof.", "According to a specific embodiment at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, more preferably at least 70%, even more preferably at least 80% and most preferably at least 90%, 95% or even 100% of the substitutable codons in the region coding for a protein or peptide as defined herein or its fragment or variant thereof or the whole sequence of the wild type mRNA sequence are substituted, thereby increasing the GC/content of said sequence.", "In this context, it is particularly preferable to increase the G/C content of the nucleic acid of the inventive polymeric carrier cargo complex, especially if the nucleic acid is in the form of an mRNA, to the maximum (i.e.", "100% of the substitutable codons), in particular in the region coding for a protein, compared to the wild-type sequence.", "According to the invention, a further preferred modification of the nucleic acid of the inventive polymeric carrier cargo complex, especially if the nucleic acid is in the form of an mRNA, the region which codes for the adjuvant protein is modified compared to the corresponding region of the wild-type mRNA such that at least one codon of the wild-type sequence which codes for a tRNA which is relatively rare in the cell is exchanged for a codon which codes for a tRNA which is relatively frequent in the cell and carries the same amino acid as the relatively rare tRNA.", "By this modification, the sequences of the nucleic acid, especially if the nucleic acid is in the form of an mRNA, is modified such that codons for which frequently occurring tRNAs are available are inserted.", "In other words, according to the invention, by this modification all codons of the wild-type sequence which code for a tRNA which is relatively rare in the cell can in each case be exchanged for a codon which codes for a tRNA which is relatively frequent in the cell and which, in each case, carries the same amino acid as the relatively rare tRNA.", "Which tRNAs occur relatively frequently in the cell and which, in contrast, occur relatively rarely is known to a person skilled in the art; cf.", "e.g.", "Akashi, Curr.", "Opin.", "Genet.", "Dev.", "2001, 11(6): 660-666.The codons which use for the particular amino acid the tRNA which occurs the most frequently, e.g.", "the Gly codon, which uses the tRNA which occurs the most frequently in the (human) cell, are particularly preferred.", "Nucleic acid molecules used according to the present invention as defined herein may be prepared using any method known in the art, including synthetic methods such as e.g.", "solid phase synthesis, as well as in vitro methods, such as in vitro transcription reactions or in vivo reactions, such as in vivo propagation of DNA plasmids in bacteria.", "According to another particularly preferred embodiment, the nucleic acid of the inventive polymeric carrier cargo complex, especially if the nucleic acid is in the form of a coding nucleic acid, preferably an mRNA, may additionally or alternatively encode a secretory signal peptide.", "Such signal peptides are sequences, which typically exhibit a length of about 15 to 30 amino acids and are preferably located at the N-terminus of the encoded peptide, without being limited thereto.", "Signal peptides as defined herein preferably allow the transport of the protein or peptide as encoded by the nucleic acid of the present invention, especially if the nucleic acid is in the form of an mRNA, into a defined cellular compartiment, preferably the cell surface, the endoplasmic reticulum (ER) or the endosomal-lysosomal compartiment.", "Any of the above modifications may be applied to the nucleic acid of the inventive polymeric carrier cargo complex, especially if the nucleic acid is in the form of an mRNA, and further to any nucleic acid as used in the context of the present invention and may be, if suitable or necessary, be combined with each other in any combination, provided, these combinations of modifications do not interfere with each other in the respective nucleic acid.", "A person skilled in the art will be able to take his choice accordingly.", "Proteins or peptides as encoded by the nucleic acid of the inventive polymeric carrier cargo complex as defined herein, may comprise fragments or variants of those sequences.", "Additionally, the nucleic acid of the inventive polymeric carrier cargo complex may comprise fragments or variants of those coding sequences.", "Such fragments or variants may typically comprise a sequence having a sequence identity with one of the above mentioned proteins or peptides or sequences of their encoding nucleic acid sequences of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, preferably at least 70%, more preferably at least 80%, equally more preferably at least 85%, even more preferably at least 90% and most preferably at least 95% or even 97%, to the entire wild-type sequence, either on nucleic acid level or on amino acid level.", "“Fragments” of proteins or peptides in the context of the present invention may comprise a sequence of an protein or peptide as defined herein, which is, with regard to its amino acid sequence (or its encoded nucleic acid sequence), N-terminally, C-terminally and/or intrasequentially truncated compared to the amino acid sequence of the original (native) protein (or its encoded nucleic acid sequence).", "Such truncation may thus occur either on the amino acid level or correspondingly on the nucleic acid level.", "A sequence identity with respect to such a fragment as defined herein may therefore preferably refer to the entire protein or peptide as defined herein or to the entire (coding) nucleic acid sequence of such a protein or peptide.", "The same applies accordingly to nucleic acids.", "Such fragments of proteins or peptides in the context of the present invention may furthermore comprise a sequence of a protein or peptide as defined herein, which has a length of about 6 to about 20 or even more amino acids, e.g.", "fragments as processed and presented by MHC class I molecules, preferably having a length of about 8 to about 10 amino acids, e.g.", "8, 9, or 10, (or even 6, 7, 11, or 12 amino acids), or fragments as processed and presented by MHC class II molecules, preferably having a length of about 13 or more amino acids, e.g.", "13, 14, 15, 16, 17, 18, 19, 20 or even more amino acids, wherein these fragments may be selected from any part of the amino acid sequence.", "These fragments are typically recognized by T-cells in form of a complex consisting of the peptide fragment and an MHC molecule, i.e.", "the fragments are typically not recognized in their native form.", "The fragments of proteins or peptides as defined herein may also comprise epitopes of those proteins or peptides.", "Epitopes (also called “antigen determinants”) in the context of the present invention are typically fragments located on the outer surface of (native) proteins or peptides as defined herein, preferably having 5 to 15 amino acids, more preferably having 5 to 12 amino acids, even more preferably having 6 to 9 amino acids, which may be recognized by antibodies or B-cell receptors, i.e.", "in their native form.", "Such epitopes of proteins or peptides may furthermore be selected from any of the herein mentioned variants of such proteins or peptides.", "In this context antigenic determinants can be conformational or discontinous epitopes which are composed of segments of the proteins or peptides as defined herein that are discontinuous in the amino acid sequence of the proteins or peptides as defined herein but are brought together in the three-dimensional structure or continuous or linear epitopes which are composed of a single polypeptide chain.", "“Variants” of proteins or peptides as defined herein may be encoded by the nucleic acid of the inventive polymeric carrier cargo complex, wherein nucleotides of the nucleic acid, encoding the protein or peptide as defined herein, are exchanged.", "Thereby, a protein or peptide may be generated, having an amino acid sequence which differs from the original sequence in one or more mutation(s), such as one or more substituted, inserted and/or deleted amino acid(s).", "Preferably, these fragments and/or variants have the same biological function or specific activity compared to the full-length native protein, e.g.", "its specific antigenic property.", "The present invention also provides a method of preparing the inventive polymeric carrier molecule according to formula (I) L-P1—S—[S—P2—S]n—S—P3-L as defined herein or according to any subformula thereof as defined herein (e.g.", "(Ia), etc.).", "It also provides the product obtained or obtainable by such an inventive method (product by process).", "The method preferably comprises following steps: a) providing at least one cationic or polycationic protein or peptide as component P2 as defined herein and/or at least one cationic or polycationic polymer as component P2 as defined herein, and optionally at least one further component (e.g.", "(AA)x, [(AAx)]z, etc.", "), preferably in the ratios indicated above by formula (I), mixing these components, preferably in a basic milieu as defined herein, preferably in the presence of oxygen or a further starter as defined herein which leads to mild oxidation conditions, preferably at a pH, at a temperature and at time as defined herein, and thereby condensing and thus polymerizing these components with each other via disulfide bonds (in a polymerization condensation or polycondensation) to obtain a repetitive component H—[S—P2—S]n—H or H{[S—P2—S]a[S-(AA)x-S]b}H, etc.", "; b) providing a hydrophilic polymer P1 and/or P3 as defined herein, optionally modified with a ligand L and/or an amino acid component (AA)x as defined herein; c) mixing the hydrophilic polymer P1 and/or P3 provided according to step b) with the repetitive component H—[S—P2—S]n—H or H{[S—P2—S]a[S-(AA)x-S]b}H, etc.", "obtained according to step a), typically in a ratio of about 2:1, (and thereby typically terminating the polymerization condensation or polycondensation reaction) and obtaining the inventive polymeric carrier, preferably according to formula (I) as defined herein or according to any subformula thereof as defined herein; d) optionally purifying the inventive polymeric carrier obtained according to step c), preferably using a method as defined herein; e) optionally adding a nucleic acid as defined herein to the inventive polymeric carrier obtained according to step c) or d), preferably in the above mentioned ratios, and complexing the nucleic acid with the polymeric carrier obtained according to step c) or d) to obtain an inventive polymeric carrier cargo complex as defined herein.", "The inventive method of preparing the inventive polymeric carrier according to formula (I) as defined herein represents a multi-step condensation polymerization or polycondensation reaction via —SH moieties of the educts, e.g.", "component(s) P2 as defined herein, further components P1 and/or P3 and optionally further components (AA)x.", "The condensation polymerization or polycondensation reaction preferably leads to the inventive polymeric carrier as a condensation polymer, wherein the single components are linked by disulfide bonds.", "This condensation polymerization leads to the inventive polymeric carrier according to formula (I) preparing in a first step a) of the condensation reaction the inventive repetitive component H—[S—P2—S]n—H or a variant thereof as a sort of a “core” or “central motif” of the inventive polymeric carrier.", "In a second step b) components P1 and/or P3 are provided, which allow to terminate or to somehow “coat” the inventive repetitive component H—[S—P2—S]n—H or a variant thereof in a third step c) by adding components P1 and/or P3 as defined herein (optionally modified with a ligand L and/or an amino acid component (AA)x as defined herein) to the condensation product obtained according to step a).", "In subsequent step d), this product may be purified and further used to complex a nucleic acid cargo as defined herein to obtain an inventive complex.", "It is important to understand that the inventive method is based on an equibrility reaction under mild oxidation conditions in steps a), (b)) and c), which, upon balancing the equilibirity state, allows to obtain the inventive polymeric carrier according to formula (I) above or according to any of its subformulas comprising the selected components in the desired molar ratios.", "For this purpose, long reaction times are envisaged to achieve an equibrility state in steps a), (b)) and c).", "If for example a condensation polymerization is to be carried out using a molar ratio of 5 components P2 in step a), the equilibrium is surprisingly settled at a polymer length of about 5 after sufficient time, preferably e.g.", ">12 hours.", "However, due to the equilibrium the polymer length (as defined by n) is not fixed at a specific value, e.g.", "5, but may vary accordingly within the equibrility reaction.", "Accordingly, about 5 may mean about 4 to 6, or even about 3 to 7.Preferably, the polymer length and thus the integer n (and thus a, b and a+b) varies within a limit of about ±1, or ±2.As defined herein in a step a) of the inventive method of preparing the inventive polymeric carrier according to formula (I) at least one cationic or polycationic protein or peptide as component P2 as defined herein and/or at least one cationic or polycationic polymer as component P2 as defined herein are provided, preferably in the ratios indicated above by formula (I).", "These components are mixed, preferably in a basic milieu as defined herein, preferably in the presence of oxygen or a further starter as defined herein which leads to mild oxidation conditions, preferably at a pH, and at a temperature and at a time as defined herein, and thereby condensing and thus polymerizing these components with each other via disulfide bonds (in a polymerization condensation or polycondensation) to obtain a repetitive component H—[S—P2—S]n—H.", "According to an alternative, in step a) of the inventive method of preparing the inventive polymeric carrier at least one cationic or polycationic protein or peptide and/or at least one cationic or polycationic polymer are provided and used as component(s) P2 as defined herein, and additionally at least one amino acid component (AA)x is provided as defined herein, and components P2 and (AA)x are used for a polymerization condensation or polycondensation according to step a).", "Preferably, the components are all provided in the ratios indicated above by formula (Ia), mixed, preferably in a basic milieu as defined herein, preferably in the presence of oxygen or a further starter as defined herein which leads to mild oxidation conditions, preferably at a pH, at a temperature and at time as defined herein.", "Upon mixing and starting the reaction, the components are condensed and thus polymerized with each other via disulfide bonds (in a polymerization condensation or polycondensation) to obtain a repetitive component H—{[S—P2—S]a[S-(AA)x-S]b}—H.", "In both of the above alternatives, different component(s) P2, particularly different peptides and/or different polymers as component P2, may be selected in the condensation polymerization as indicated above.", "In this context, the selection of different component(s) P2 is typically dependent upon the desired properties of the final inventive polymeric carrier and the desired cationic strength of the final inventive polymeric carrier or its central core motif.", "Accordingly, the repetitive component [S—P2—S]n, may furthermore be “diluted” or modified in the above alternative of step a) e.g.", "by introducing an amino acid component (AA)x as defined herein, preferably in the above defined ratios.", "Thereby, a modified central core motif {[S—P2—S]a[S-(AA)x-S]b} may be obtained, wherein the cationic character of (unmodified) repetitive component [S—P2—S]n typically remains in the limitations as defined herein.", "The properties of the final inventive polymeric carrier may thus be adjusted as desired with properties of components (AA)x by inserting amino acid component (AA)x as defined herein in steps a), b) and/or c).", "In all cases, step a) is based on an equibrility reaction under mild oxidation conditions which, upon balancing the equilibirity state, allows to obtain either inventive repetitive component H—[S—P2—S]n—H or inventive repetitive component H—{[S—P2—S]a/[S-(AA)x-S]b}—H in the desired molar ratios.", "In the equilibirity state, n is preferably 1, 2, 3, 4, or 5 to 10, more preferably 4 to 9, and a+b=n is as defined above, preferably a+b=1, 2, 3, 4, or 5 to 10, more preferably 4 to 9.For this purpose, long reaction times are envisaged to achieve an equibrility state in step a), most preferably e.g.", ">12 hours.", "Accordingly, step a) of the inventive method of preparing a polymeric carrier typically requires at least about 5 hours, even more preferably at least about 7.5 hours or even 10 hours, most preferably at least about 12 hours, e.g.", "a reaction time of about 12 to 60 hours, a reaction time of about 12 to 48 hours, a reaction time of about 12 to 36 hours, or a reaction time of about 12 to 24 hours, etc, wherein the lower border of 12 hours of the latter ranges may also be adjusted to 10, 7.5, or even 5 hours.", "Advantageously, the equilibirity state can be balanced using the inventive method.", "In step a), the at least one cationic or polycationic protein or peptide as component P2 as defined herein and/or at least one cationic or polycationic polymer as component P2 as defined herein, and optionally at least one amino acid component (AA)x as defined herein, are preferably contained in a basic milieu in the step a) of the inventive method of preparing the inventive polymeric carrier according to formula (I) (or any of its subformulas, e.g.", "(Ia)).", "Such a basic milieu typically exhibits a pH range of about 6 to about 12, preferably a pH range of about 7 to about 10, more preferably a pH range of about 8 to about 10, e.g.", "about 8, 8.5, 9, 9.5, or 10 or any range selected from any two of these or the aforementioned values.", "20 Furthermore, the temperature of the solution in step a) is preferably in a range of about 5° C. to about 60° C., more preferably in a range of about 15° C. to about 40° C., even more preferably in a range of about 20° C. to about 30° C., and most preferably in a range of about 20° C. to about 25° C., e.g.", "about 25° C. In step a) of the inventive method of preparing the inventive polymeric carrier according to formula (I) (or any of its subformulas, e.g.", "(Ia)) as defined herein buffers may be used as suitable.", "Preferred buffers may comprise, but are not limited to carbonate buffers, borate buffers, Bicine buffer, CHES buffer, CAPS buffer, Ethanolamine containing buffers, HEPES, MOPS buffer, Phosphate buffer, PIPES buffer, Tris buffer, Tricine buffer, TAPS buffer, and/or TES buffer as buffering agents.", "Particularly preferred is a carbonate buffer.", "Upon mixing the components, preferably in the presence of oxygen, preferably in the presence of a basic mileu as defined herein, the condensation polymerization or polycondensation reaction is started.", "For this purpose, the mixture in step a) is preferably exposed to oxygen or may be started using a further starter, e.g.", "a catalytical amount of an oxidizing agent, e.g.", "DMSO, etc.", "To determine the desired polymer chain length the condensation reaction has to be carried out under mild oxidation conditions, preferably in the presencence of less than 30% DMSO, more preferably in the presence of less than 20% DMSO and most preferably in the presence of less than 10% DMSO.", "Upon start of the condensation polymerization or polycondensation reaction the at least one cationic or polycationic protein or peptide and/or at least one cationic or polycationic polymer as component P2 and optionally at least one amino acid component (AA)x as defined herein, are condensed and thus polymerized with each other via disulfide bonds (polymerization condensation or polycondensation).", "In this reaction step a) preferably linear polymers are created using monomers with at least two reactive —SH moieties, i.e.", "at least one cationic or polycationic protein or peptide and/or at least one cationic or polycationic polymer as component P2 as defined herein, each component P2 exhibiting at least two free —SH-moieties as defined herein, e.g.", "at their terminal ends.", "However, components P2 with more than two free —SH-moieties may be used, which may lead to branched polymers.", "According to one other specific embodiment, the condensation product obtained according to step a) may be modified (e.g.", "in a step al)) by adding an amino acid component (AA)x or a mixed repetitive amino acid component [(AA)x]z as defined herein e.g.", "to the terminal ends of the condensation product of step a).", "This may occur via any functionality as defined herein, e.g a —SH moiety or any further functionality described herein, preferably a —SH moiety.", "For this purpose, amino acid component (AA)x or a mixed repetitive amino acid component [(AA)x]z may be provided with two (or even more) —SH-moieties, e.g.", "in a form represented by formulae “H(S-AA-S)xH” or “H[S-(AA)x-S]zH”.", "Then, a polycondensation fraction may be carried out with the products of step a), i.e.", "inventive repetitive component H—[S—P2—S]n—H or inventive repetitive component H—{[S—P2—S]a[S-(AA)x-S]b}—H, leading to intermediate components H(S-AA-S)x—[S—P2—S]n—(S-AA-S)xH, or H [S-(AA)x-S]z—[S—P2—S]n—[S-(AA)x-S]zH, or H(S-AA-S)x—{[S—P2—S]a[S-(AA)x-S]b}—(S-AA-S)xH, or H [S-(AA)x-S]z—{[S—P2—S]a[S-(AA)x-S]b}—[S-(AA)x-S]zH.", "Any single or all of these intermediate components or the inventive repetitive component H—[S—P2—S]n—H or the inventive repetitive component H—{[S—P2—S]a[S-(AA)x-S]b}—H obtained according to step a), may be used to be coupled to the polymers provided in step b) of the inventive method.", "According to a second step b) of the inventive method of preparing the inventive polymeric carrier according to formula (I) as defined herein (or according to any of its subformulas), a hydrophilic polymer P1 and/or P3 as defined herein is added to the condensation product obtained according to step a).", "In this context, the hydrophilic polymers P1 and/or P3 as defined herein, preferably exhibit at least one —SH-moiety, more preferably only one —SH-moiety per hydrophilic polymers P1 and/or P3 as defined herein, thereby terminally stopping the polymerization condensation or polycondensation according to step a) in step c).", "Hydrophilic polymers P1 and/or P3 as defined herein may be the same or different, wherein these polymers may be selected according to the desired properties.", "Typically, hydrophilic polymers P1 and/or P3 as a whole may be added to the condensation product obtained according to step a) in a ratio of about 2:1 hydrophilic polymer P1 and/or P3: condensation product obtained according to step a).", "According to one alternative, the hydrophilic polymer(s) P1 and/or P3 additionally may be modified with either a component L (ligand) as defined herein or a component (AA)x or [(AA)x]z as defined herein or both a component L (ligand) as defined herein and a component (AA)x or [(AA)x]z as defined herein.", "According to a first example, a ligand is attached to component(s) P1 and/or P3 as component L prior to providing component(s) P1 and/or P3 in step b) via any functionality as defined herein, e.g a —SH moiety.", "This ligand is preferably attached to the hydrophilic polymer(s) P1 and/or P3 at one terminus of these polymers.", "If the attachment is carried out via —SH bonds, the hydrophilic polymer(s) P1 and/or P3 are preferably provided with two (or even more) —SH-moieties, e.g.", "in a form represented by formulae HS—P1—SH or HS—P3—SH.", "Ligand L preferably carries only one —SH moiety.", "In this case, one —SH moiety of hydrophilic polymer(s) P1 and/or P3 is preferably protected in a first step using a protecting group as known in the art.", "Then, the hydrophilic polymer(s) P1 and/or P3 may be bound to a component L to form a first disulfide bond via the non-protected —SH moiety.", "The protected —SH-moiety of hydrophilic polymer(s) P1 and/or P3 is then typically deprotected for further reactions.", "This preferably leads to following intermediate components L-S—S—P1—SH, or HS—P3—S—S-L. Alternatively, the above intermediate components may be provided similarly without the necessity of blocking the free —SH-moieties.", "These intermediate components may be used in step c) to be coupled with the condensation products obtained according to step a) above, e.g.", "to form a second disulfide bond with inventive repetitive component H—[S—P2—S]n—H or inventive mixed repetitive component H—{[S—P2—S]a[S-(AA)x-S]b}—H obtained according to step a) or any of its modifications, e.g.", "according to step al).", "If the attachment is carried out via other moieties, any of the reactions as defined herein may be used accordingly.", "According to a further example, an amino acid component (AA)x or a mixed repetitive amino acid component [(AA)x]z as defined herein may be attached to component(s) P1 and/or P3 prior to providing component(s) P1 and/or P3 via any functionality as defined herein, e.g a —SH moiety.", "The amino acid component (AA)x or a mixed repetitive amino acid component [(AA)x]z may be attached to the hydrophilic polymer(s) P1 and/or P3 at any position within these polymers or at one or both termini of these polymers.", "In one specific case, the amino acid component (AA)x or a mixed repetitive amino acid component [(AA)x]z may be provided as a linker between component(s) P1 and/or P3 and the condensation product obtained according to step a) above or as a linker between component(s) P1 and/or P3 and a further component, e.g.", "a linker L, or according to another alternative, as a terminating component at one terminus of component(s) P1 and/or P3.In any of these cases, the attachment preferably may carried out via —SH bonds, wherein the hydrophilic polymer(s) P1 and/or P3 are preferably provided with two (or even more) —SH-moieties, e.g.", "in a form represented by formula “HS—P1—SH” or “HS—P3—SH”, wherein preferably one of these to —SH moieties is protected, e.g.", "in a form represented by formula “HS—P1—S-protecting group” or “protecting group-S—P3—SH”.", "Furthermore, amino acid component (AA)x or a mixed repetitive amino acid component [(AA)x]z are also preferably provided with two (or even more) —SH-moieties, e.g.", "in a form represented by formulae “H(S-AA-S)x—H” or “H[S-(AA)x—S]zH”, wherein preferably one of these to —SH moieties is protected, e.g.", "in a form represented by formulae “protecting group-(S-AA-S)x—SH” or “H [S-(AA)x-S]z-protecting group”.", "Then, a polycondensation reaction may be carried out with polymers “HS—P1—S-protecting group” or “protecting group-S—P3—SH” leading to intermediate components “protecting group-S—P1—S—(S-AA-S)x—S-protecting group”, “protecting group-(S-AA-S)—S—S—P3—S-protecting group”, “protecting group-S—P1—S— [S-(AA)x-S]z-protecting group”, or “protecting group-[S-(AA)x-S]z—S—P3—S-protecting group”.", "Any single or all of these intermediate components may then be used in step c) of the inventive method to be coupled to the condensation product according to step a).", "For this purpose, at least one or both protecting groups (selected upon the desired direction of the component in the final carrier) of each intermediate compound may be deprotected prior to providing them in step b), leading to following intermediate components “HS—P1—S—(S-AA-S))x—SH”, “H(S-AA-S)x—S—S—P3—SH”, “HS—P1—S—[S-(AA)x-S]zH”, or “H [S-(AA)x-S]z—S—P3—SH”, Alternatively, the above intermediate components may be provided similarly without the necessity of blocking the free —SH-moieties.", "Any single or all of these intermediate components may then be provided in step b) of the inventive method to be coupled to the condensation product according to step a).", "If any of the afore mentioned intermediate components is provided in step b), this condensation reaction may be terminated in a step c) by adding a linker component as defined herein with one —SH-moiety (e.g.", "L-SH) or any further component with a single —SH moiety, e.g.", "as defined herein.", "In one further specific case, the amino acid component (AA)x or a mixed repetitive amino acid component [(AA)x]z may be used as a terminal component at one terminus of component(s) P1 and/or P3 without adding a further component to the amino acid component (AA)x or a mixed repetitive amino acid component [(AA)x]z.", "According to a further example, an amino acid component (AA)x or a mixed repetitive amino acid component [(AA)x]z as defined herein may be attached to component(s) P1 and/or P3 prior to step c), wherein component(s) P1 and/or P3 have been already modified with a linker.", "For this purpose, component(s) P1 and/or P3 preferably carry (at least) two —SH moieties as defined herein, wherein a polycondensation is carried out with a linker, carrying e.g.", "one —SH moiety.", "This reaction may be carried out by using protecting groups as defined herein, or, preferably, without protecting groups.", "Alternatively, any further functionality as defined herein except —SH moieties may be used for coupling.", "Then, the second —SH moiety of component(s)P and/or P3 may be used to couple an amino acid component (AA)x or a mixed repetitive amino acid component [(AA)z], as defined herein via —SH-moieties, e.g.", "in a form represented by formulae “H(S-AA-S)x—H” or “H[S-(AA)x-S]zH”.", "The reaction preferably leads to following intermediate compounds “L-S—S—P1—S—(S-AA-S)x—SH”, “L-S—S—P1—S— [S-(AA)x-S]zH”, or “HS—(S-AA-S)x—S—S—P3—S—S-L”, or “H S— [S-(AA)x-S]z—S—P3—S—S-L”; or, if component L has been linked without a dislufide bond to following intermediate products “L-P1—S—(S-AA-S)x—SH”, “L-P1—S—[S-(AA)x-S]zH”, or “HS—(S-AA-S)x—S—S—P3-L”, or “HS—[S-(AA)x-S]z—S—P3-L”; In step c) the hydrophilic polymers P1 and/or P3 (or any of the intermediate components provided according to step b)) as defined herein, are provided and mixed with the repetitive component H—[S—P2—S]n—H, with the mixed repetitive component H—{[S—P2—S]a[S-(AA)x-S]b}—H, or any of the intermediate components obtained according to step a), typically in a ratio of about 2:1.The reaction is typically started and carried out under conditions already described above for step a) (pH, temperature, reaction time, buffers, etc.).", "Step c) allows to terminate the polymerization condensation or polycondensation reaction and to obtain the inventive polymeric carrier according to formula (I) or (Ia) or according to any of subformulas thereof as defined herein, preferably the inventive polymeric carrier according to formula (I) L-P1—S—[S—P2—S]n—S—P3-L or according to formula (Ia) L-P1—S—{[S—P2—S]a[S-(AA)x-S]b}—S—P3-L.", "According to a further step d) of the inventive method of preparing the inventive polymeric carrier according to formula (I) or (Ia) as defined herein, or according to any of subformulas thereof as defined herein, the inventive polymeric carrier obtained according to step c) is optionally purified.", "Purification may occur by using chromatographic methods, such as HPLC, FPLC, GPS, dialysis, etc.", "According to a final step e) of the inventive method of preparing the inventive polymeric carrier according to formula (I) or (Ia) as defined herein, or according to any of subformulas thereof as defined herein, a nucleic acid as defined herein is optionally added to the inventive polymeric carrier obtained according to step c) or d), preferably in the above mentioned ratios.", "Typically, in the inventive complex, the polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein, as defined herein and the nucleic acid are provided in a molar ratio of about 5 to 10000, preferably in a molar ratio of about 5 to 5000, more preferably in a molar ratio of about 5 to 2500, even more preferably in a molar ratio of about 5 to 1000 polymeric carrier:nucleic acid, e.g.", "in a molar ratio of about 10 to 10000, in a molar ratio of about 10 to 5000, in a molar ratio of about 25 to 2500, or in a molar ratio of about 50 to 1000 polymeric carrier:nucleic acid.", "The N/P ratios are preferably as indicated above.", "The inventive method of preparing the inventive polymeric carrier according to formula (I) or (Ia) or according to any of subformulas thereof as defined herein is particularly suitable to adapt the chemical properties of the desired inventive polymeric carrier due to specific selection of its components P2, L, (AA)x, or [(AA)x]z thereby avoiding agglomeration and toxicity in vivo.", "Furthermore, a skilled person would not have expected to obtain an inventive polymeric carrier using the above inventive method as the skilled person would always have expected that the polymer obtained according to the inventive method due to general rules of equilibirity reactions leads to a monomeric content of component P2, flanked by monomeric components P1 and/or P3, wherein the linkages are formed by disulfide bonds.", "In contrast, the present inventors were surprisingly able to show that when using a specific ratio of polymers and method steps as defined herein, particularly mild oxidation conditions during the polymerization reaction, the polymerization condensation can be directed to specifically obtain a desired distribution of polymers and a desired average length and the desired inventive polymeric carrier according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein without the necessity of blocking the free —SH-moieties.", "This was not expected by a skilled person.", "According to a further embodiment, the present invention also provides a pharmaceutical composition, comprising the inventive polymeric carrier cargo complex formed by a nucleic acid cargo as defined herein and a polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein and optionally a pharmaceutically acceptable carrier and/or vehicle.", "As a first ingredient, the inventive pharmaceutical composition comprises the polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein.", "As a second ingredient the inventive pharmaceutical composition may comprise at least one additional pharmaceutically active component.", "A pharmaceutically active component in this connection is a compound that has a therapeutic effect to heal, ameliorate or prevent a particular indication, preferably cancer diseases, autoimmune disease, allergies or infectious diseases.", "Such compounds include, without implying any limitation, peptides or proteins, preferably as defined herein for coding nucleic acids, nucleic acids, preferably as defined herein, (therapeutically active) low molecular weight organic or inorganic compounds (molecular weight less than 5000, preferably less than 1000), sugars, antigens or antibodies, preferably as defined herein, therapeutic agents already known in the prior art, antigenic cells, antigenic cellular fragments, cellular fractions; cell wall components (e.g.", "polysaccharides), modified, attenuated or de-activated (e.g.", "chemically or by irradiation) pathogens (virus, bacteria etc.", "), adjuvants, preferably as defined herein, etc.", "Furthermore, the inventive pharmaceutical composition may comprise a pharmaceutically acceptable carrier and/or vehicle.", "In the context of the present invention, a pharmaceutically acceptable carrier typically includes the liquid or non-liquid basis of the inventive inventive pharmaceutical composition.", "If the inventive pharmaceutical composition is provided in liquid form, the carrier will typically be pyrogen-free water; isotonic saline or buffered (aqueous) solutions, e.g phosphate, citrate etc.", "buffered solutions.", "Particularly for injection of the inventive inventive pharmaceutical composition, water or preferably a buffer, more preferably an aqueous buffer, may be used, containing a sodium salt, preferably at least 50 mM of a sodium salt, a calcium salt, preferably at least 0.01 mM of a calcium salt, and optionally a potassium salt, preferably at least 3 mM of a potassium salt.", "According to a preferred embodiment, the sodium, calcium and, optionally, potassium salts may occur in the form of their halogenides, e.g.", "chlorides, iodides, or bromides, in the form of their hydroxides, carbonates, hydrogen carbonates, or sulfates, etc.", "Without being limited thereto, examples of sodium salts include e.g.", "NaCl, Nal, NaBr, Na2CO3, NaHCO3, Na2SO4, examples of the optional potassium salts include e.g.", "KCl, Kl, KBr, K2CO3, KHCO3, K2SO4, and examples of calcium salts include e.g.", "CaCl2, CaI2, CaBr2, CaCO3, CaSO4, Ca(OH)2.Furthermore, organic anions of the aforementioned cations may be contained in the buffer.", "According to a more preferred embodiment, the buffer suitable for injection purposes as defined herein, may contain salts selected from sodium chloride (NaCl), calcium chloride (CaCl2) and optionally potassium chloride (KCl), wherein further anions may be present additional to the chlorides.", "CaCl2 can also be replaced by another salt like KCl.", "Typically, the salts in the injection buffer are present in a concentration of at least 50 mM sodium chloride (NaCl), at least 3 mM potassium chloride (KCl) and at least 0.01 mM calcium chloride (CaCl2).", "The injection buffer may be hypertonic, isotonic or hypotonic with reference to the specific reference medium, i.e.", "the buffer may have a higher, identical or lower salt content with reference to the specific reference medium, wherein preferably such concentrations of the afore mentioned salts may be used, which do not lead to damage of cells due to osmosis or other concentration effects.", "Reference media are e.g.", "liquids occurring in “in vivo” methods, such as blood, lymph, cytosolic liquids, or other body liquids, or e.g.", "liquids, which may be used as reference media in “in vitro” methods, such as common buffers or liquids.", "Such common buffers or liquids are known to a skilled person.", "Ringer-Lactate solution is particularly preferred as a liquid basis.", "According to another aspect, the inventive pharmaceutical composition may comprise an adjuvant.", "In this context, an adjuvant may be understood as any compound, which is suitable to initiate or increase an immune response of the innate immune system, i.e.", "a non-specific immune response.", "With other words, when administered, the inventive pharmaceutical composition typically elicits an innate immune response due to the adjuvant, optionally contained therein.", "Such an adjuvant may be selected from any adjuvant known to a skilled person and suitable for the present case, i.e.", "supporting the induction of an innate immune response in a mammal.", "The inventive pharmaceutical composition may be administered orally, parenterally, by inhalation spray, topically, rectally, nasally, buccally, vaginally or via an implanted reservoir.", "The term parenteral as used herein includes subcutaneous, intravenous, intramuscular, intra-articular, intra-synovial, intrasternal, intrathecal, intrahepatic, intralesional, intracranial, transdermal, intradermal, intrapulmonal, intraperitoneal, intracardial, intraarterial, and sublingual injection or infusion techniques.", "The inventive pharmaceutical composition may be used for human and also for veterinary medical purposes, preferably for human medical purposes, as a pharmaceutical composition in general or as a vaccine.", "According to a particular preferred aspect, the inventive pharmaceutical composition (or the inventive polymeric carrier cargo complex) may be provided or used as an immunostimulating agent.", "In this context, the inventive pharmaceutical composition is preferably as defined above.", "More preferably, the nucleic acid of the inventive polymeric carrier cargo complex, preferably contained in the pharmaceutical composition, is typically an immunostimulatory nucleic acid as defined herein, e.g.", "a CpG-DNA or an immunostimulatory RNA (isRNA).", "Alternatively or additionally, the nucleic acid of the inventive polymeric carrier cargo complex, preferably contained in the pharmaceutical composition, is a coding nucleic acid as defined herein, preferably a cDNA or an mRNA, more preferably encoding an adjuvant protein preferably as defined herein.", "In a specific aspect of this embodiment in this context it is preferred that an adjuvant protein is a component of the polymeric carrier, preferably as (AA)x, component.", "According to an even more preferred aspect, the inventive pharmaceutical composition (or the inventive polymeric carrier cargo complex) may be provided or used as an adjuvant.", "In this context, the adjuvant is preferably defined as the inventive pharmaceutical composition above.", "More preferably, the nucleic acid of the inventive polymeric carrier cargo complex, preferably contained in the adjuvant, is typically an immunostimulatory nucleic acid as defined herein, e.g.", "a CpG-DNA or an immunostimulatory RNA (isRNA).", "Alternatively or additionally, the nucleic acid of the inventive polymeric carrier cargo complex, preferably contained in the adjuvant, is a coding nucleic acid as defined herein, preferably a cDNA or an mRNA, more preferably encoding an adjuvant protein, preferably as defined herein.", "The inventive polymeric carrier cargo complex, preferably contained in the adjuvant, typically initiates an innate immune response in the patient to be treated.", "Such an adjuvant may be utilized in any accompanying therapy, with any known vaccine or any further (known) therapeutic agent, preferably prior to, concurrent with or subsequent to administration of the main therapy, prior to, concurrent with or subsequent to administration of a further (known) vaccine or a (known) further therapeutic agent.", "The inventive polymeric carrier cargo complex or the inventive pharmaceutical composition as defined herein provided or used as an adjuvant is preferably capable of triggering a non-antigen-specific, (innate) immune reaction (as provided by the innate immune system), preferably in an immunostimulating manner.", "An immune reaction can generally be brought about in various ways.", "An important factor for a suitable immune response is the stimulation of different T-cell sub-populations.", "T-lymphocytes typically differentiate into two sub-populations, the T-helper 1 (Th1) cells and the T-helper 2 (Th2) cells, with which the immune system is capable of destroying intracellular (Th1) and extracellular (Th2) pathogens (e.g.", "antigens).", "The two Th cell populations differ in the pattern of effector proteins (cytokines) produced by them.", "Thus, Th1 cells assist the cellular immune response by activation of macrophages and cytotoxic T-cells.", "Th2 cells, on the other hand, promote the humoral immune response by stimulation of B-cells for conversion into plasma cells and by formation of antibodies (e.g.", "against antigens).", "The Th1/Th2 ratio is therefore of great importance in the immune response.", "In connection with the present invention, the Th1/Th2 ratio of the immune response is preferably displaced by the immune-stimulating agent, namely the inventive polymeric carrier cargo complex in the direction towards the cellular response, that is to say the Th1 response, and a predominantly cellular immune response is thereby induced.", "As defined above, the inventive polymeric carrier cargo complex exerts by itself an unspecific innate immune response, which allows the inventive polymeric carrier cargo complex be used as such (without adding another pharmaceutically active component) as an immunostimulating agent.", "If administered together with another pharmaceutically active component, preferably a specifically immunogenic component, preferably an antigen, the nucleic acid of the invention serves as an adjuvant supporting the specific adaptive immune response elicited by the other pharmaceutically active component e.g.", "an antigen.", "According to another particularly preferred embodiment, the inventive pharmaceutical composition (or the inventive polymeric carrier cargo complex) may be provided or used as a vaccine.", "Such an inventive vaccine is typically composed like the inventive pharmaceutical composition and preferably supports or elicits an immune response of the immune system of a patient to be treated, e.g.", "an innate immune response, if an RNA or mRNA is used as the nucleic acid molecule of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein.", "Furthermore or alternatively, the inventive vaccine may elicit an adaptive immune response, preferably, if the nucleic acid of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein encodes any of the above mentioned antigens or proteins, which elicit an adaptive immune response.", "In this context, the vaccine is preferably defined as an adjuvant or as an inventive pharmaceutical composition as disclosed above.", "More preferably, the nucleic acid of the inventive polymeric carrier cargo complex, contained in such a vaccine, may be any nucleic acid as defined above, preferably an immunostimulatory nucleic acid as defined herein, e.g.", "a CpG-DNA or an immunostimulatory RNA (isRNA).", "Alternatively or additionally, the nucleic acid of the inventive polymeric carrier cargo complex, preferably contained in the vaccine, is a coding nucleic acid as defined herein, preferably a cDNA or an mRNA, more preferably encoding an adjuvant protein, preferably as defined herein.", "Alternatively or additionally, the nucleic acid of the inventive polymeric carrier cargo complex, preferably contained in the vaccine, is a coding nucleic acid as defined herein, preferably a cDNA or an mRNA, more preferably encoding an antigen, preferably as defined herein.", "Furthermore, particularly, if the nucleic acid of the inventive polymeric carrier cargo complex does not encode an antigen, the inventive vaccine may contain an antigen, preferably as defined above, either as a protein or peptide or encoded by a nucleic acid, or antigenic cells, antigenic cellular fragments, cellular fractions; cell wall components (e.g.", "polysaccharides), modified, attenuated or de-activated (e.g.", "chemically or by irradiation) pathogens (virus, bacteria etc.).", "According to a further aspect the inventive vaccine may contain a peptide or protein antigen as (AA)x component of the inventive polymeric carrier as defined herein, preferably as part of the repetitive component [S—P2—S]n. The inventive vaccine may also comprise a pharmaceutically acceptable carrier, adjuvant, and/or vehicle as defined herein for the inventive pharmaceutical composition.", "The inventive vaccine can additionally contain one or more auxiliary substances in order to increase its immunogenicity, if desired.", "A synergistic action of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and a polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein and of an auxiliary substance, which may be optionally contained in the inventive vaccine as defined herein, is preferably achieved thereby.", "Depending on the various types of auxiliary substances, various mechanisms can come into consideration in this respect.", "For example, compounds that permit the maturation of dendritic cells (DCs), for example lipopolysaccharides, TNF-alpha or CD40 ligand, form a first class of suitable auxiliary substances.", "In general, it is possible to use as auxiliary substance any agent that influences the immune system in the manner of a “danger signal” (LPS, GP96, etc.)", "or cytokines, such as GM-CFS, which allow an immune response to be enhanced and/or influenced in a targeted manner.", "Particularly preferred auxiliary substances are cytokines, such as monokines, lymphokines, interleukins or chemokines, that further promote the innate immune response, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, IL-20, IL-21, IL-22, IL-23, IL-24, IL-25, IL-26, IL-27, IL-28, IL-29, IL-30, IL-31, IL-32, IL-33, IFN-alpha, IFN-beta, IFN-gamma, GM-CSF, G-CSF, M-CSF, LT-beta or TNF-alpha, growth factors, such as hGH.", "Further additives which may be included in the inventive vaccine are emulsifiers, such as, for example, Tween®; wetting agents, such as, for example, sodium lauryl sulfate; colouring agents; taste-imparting agents, pharmaceutical carriers; tablet-forming agents; stabilizers; antioxidants; preservatives.", "The inventive vaccine can also additionally or alternatively contain any further compound, which is known to be immune-stimulating due to its binding affinity (as ligands) to human Toll-like receptors TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, or due to its binding affinity (as ligands) to murine Toll-like receptors TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12 or TLR13.Another class of compounds, which may be added to an inventive vaccine in this context, may be CpG nucleic acids, in particular CpG-RNA or CpG-DNA.", "A CpG-RNA or CpG-DNA can be a single-stranded CpG-DNA (ss CpG-DNA), a double-stranded CpG-DNA (dsDNA), a single-stranded CpG-RNA (ss CpG-RNA) or a double-stranded CpG-RNA (ds CpG-RNA).", "The CpG nucleic acid is preferably in the form of CpG-RNA, more preferably in the form of single-stranded CpG-RNA (ss CpG-RNA).", "The CpG nucleic acid preferably contains at least one or more (mitogenic) cytosine/guanine dinucleotide sequence(s) (CpG motif(s)).", "According to a first preferred alternative, at least one CpG motif contained in these sequences, that is to say the C (cytosine) and the G (guanine) of the CpG motif, is unmethylated.", "All further cytosines or guanines optionally contained in these sequences can be either methylated or unmethylated.", "According to a further preferred alternative, however, the C (cytosine) and the G (guanine) of the CpG motif can also be present in methylated form.", "The inventive vaccine can also additionally or alternatively contain an immunostimulatory RNA, i.e.", "an RNA derived from an immunostimulatory RNA, which triggers or increases an (innate) immune response.", "Preferably, such an RNA may be in general as defined herein for RNAs.", "In this context, those classes of RNA molecules, which can induce an innate immune response, may be selected e.g.", "from ligands of Toll-like receptors (TLRs), particularly from RNA sequences representing and/or encoding ligands of TLRs, preferably selected from human family members TLR1-TLR10 or murine family members TLR1-TLR13, more preferably from TLR7 and TLR8, ligands for intracellular receptors for RNA (such as RIG-I or MDA-5, etc.)", "(see e.g.", "Meylan, E., Tschopp, J.", "(2006).", "Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses.", "Mol.", "Cell 22, 561-569), or any other immunostimulatory RNA sequence.", "Such an immunostimulatory RNA may comprise a length of 1000 to 5000, of 500 to 5000, of 5 to 5000, or of 5 to 1000, 5 to 500, 5 to 250, of 5 to 100, of 5 to 50 or of 5 to 30 nucleotides.", "The present invention furthermore provides several applications and uses of the inventive polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein, the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and the inventive polymeric carrier molecule, a pharmaceutical composition comprising same or of kits comprising same.", "According to one embodiment, the present invention is directed to the first medical use of the inventive polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein, of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and the inventive polymeric carrier molecule, or of kits comprising same, as a medicament, preferably for gene therapy or treatment of a disease as defined herein.", "The medicament may be in the form of a pharmaceutical composition or in the form of an adjuvant or a vaccine as a specific form of pharmaceutical compositions.", "A pharmaceutical composition in the context of the present invention typically comprises the inventive polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein or the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and the inventive polymeric carrier molecule, optionally further ingredients, e.g.", "as defined herein for the inventive nucleic acid, and optionally a pharmaceutically acceptable carrier and/or vehicle, preferably as defined herein.", "According to one further embodiment, the present invention is directed to the use of the inventive polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein, preferably with a nucleic acid cargo as defined herein, or of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and the inventive polymeric carrier molecule for the prophylaxis, treatment and/or amelioration of diseases as defined herein.", "Preferably, diseases as mentioned herein are selected from cancer or tumour diseases, infectious diseases, preferably (viral, bacterial or protozoological) infectious diseases, autoimmune diseases, allergies or allergic diseases, monogenetic diseases, i.e.", "(hereditary) diseases, or genetic diseases in general, diseases which have a genetic inherited background and which are typically caused by a defined gene defect and are inherited according to Mendel's laws, cardiovascular diseases, neuronal diseases, diseases of the respiratory system, diseases of the digestive system, diseases of the skin, musculoskeletal disorders, disorders of the connective tissue, neoplasms, immune deficiencies, endocrine, nutritional and metabolic diseases, eye diseases, ear diseases and any disease which can be influenced by the present invention.", "According to another embodiment, the present invention is directed to the second medical use of the inventive polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein, or of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and the inventive polymeric carrier molecule for the treatment of diseases as defined herein, preferably to the use of the inventive polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein, or of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and the inventive polymeric carrier molecule, of a pharmaceutical composition comprising same or of kits comprising same for the preparation of a medicament for the prophylaxis, treatment and/or amelioration of various diseases as defined herein.", "According to one further embodiment, the present invention is directed to the use of the inventive polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein, preferably with a nucleic acid cargo as defined herein, or of the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and the inventive polymeric carrier molecule for immunotherapy, for gene therapy, for vaccination, or to the use thereof as an adjuvant.", "According to a further embodiment, the present invention is directed to the treatment of diseases as defined herein, particularly prophylaxis, treatment and/or amelioration of various diseases as defined herein, preferably using or administering to a patient in need thereof the inventive polymeric carrier cargo complex formed by the nucleic acid cargo and the inventive polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein, or the inventive pharmaceutical composition or vaccine as defined herein.", "The present invention also allows treatment of diseases, which have not been inherited, or which may not be summarized under the above categories.", "Such diseases may include e.g.", "the treatment of patients, which are in need of a specific protein factor, e.g.", "a specific therapeutically active protein as mentioned above.", "This may e.g.", "include dialysis patients, e.g.", "patients which undergo a (regular) a kidney or renal dialysis, and which may be in need of specific therapeutically active proteins as defined herein, e.g.", "erythropoietin (EPO), etc.", "According to a final embodiment, the present invention also provides kits, particularly kits of parts, comprising as components alone or in combination with further ingredients at least one inventive polymeric carrier molecule according to generic formula (I) or (Ia) or according to any of subformulas thereof as defined herein, at least one inventive polymeric carrier cargo complex formed by the nucleic acid cargo and the inventive polymeric carrier molecule, at least one nucleic acid as defined herein, at least one pharmaceutical composition comprising same and/or kits comprising same, and optionally technical instructions with information on the administration and dosage of the inventive polymeric carrier molecule, the nucleic acid, the inventive polymeric carrier complex, and/or the inventive pharmaceutical composition.", "Such kits, preferably kits of parts, may be applied, e.g., for any of the above mentioned applications or uses.", "Such kits, when occurring as a kit of parts, may further contain each component in a different part of the kit.", "FIGURES The following Figures are intended to illustrate the invention further.", "They are not intended to limit the subject matter of the invention thereto.", "FIG.", "1: illustrates the products formed during the reaction by SDS PAGE gel electrophoresis under non-reducing conditions.", "The left part of the gel was stained according to coomassie protocol which colors the peptide content, the right part was stained with Bariumchloride/Iodine solutions which colour the PEG content.", "As may be easily seen only one product containing PEG and peptide is formed in the range of the intended mass.", "FIG.", "2: shows the results of the confocal microscopy of L929 cells 5 minutes after transfection with fluorescence labelled RNA complexed with the inventive polymeric carrier PB19 in a molar ratio of 1:500.As a result, several complexes are detectable in the cells already 5 minutes after transfection indicating a good transfection rate.", "FIG.", "3: shows the results of the confocal microscopy of L929 cells 1 hour after transfection with fluorescence labelled RNA complexed with the inventive polymeric carrier PB19 in a molar ratio of 1:500.As a result, most of the particles were taken up in the cells 1 hour after transfection showing a good transfection rate.", "FIG.", "4: illustrates stability experiments with regard to electrostatic displacement of the bound nucleic acid from the complex.", "As can be seen the addition of the anionic polymer heparin can not displace the RNA from the complex because it still migrates in the gel.", "This indicates that the complex binding is so strong that a competitive complex partner cannot displace the RNA from the complex.", "FIG.", "5: depicts a gel shift assay to examine the strength of complex binding.", "It could be shown that the addition of the anionic polymer heparin or the reducing agent DTT alone cannot display the RNA from the complex with the polymer according to the invention (PB19).", "Only together they are able to displace the RNA from the complex (lane 7).", "This indicates that the complex binding is so strong that neither a competitive complex partner nor a reducing agent can displace the RNA from the complex.", "FIG.", "6: shows a gel shift assay to examine the strength of complex binding.", "As can be seen, the addition of the anionic polymer heparin alone cannot displace the RNA from the complex with polymers according to the invention (PB22).", "In contrast mRNA could be readily displaced by heparin from PEI complexes.", "FIG.", "7: depicts the results from expression experiments with of luciferase encoding mRNA according to SEQ ID NO: 369 in HeLa cells.", "As can be seen, formulations of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 with the PB19 polymer (molar ratio of RNA:PB19 1:1000, 1:500, 1:100) lead to expression of luciferase independently of the presence of serum containing medium.", "These results are unexpected because serum containing medium leads in general to a loss of transfection efficiency.", "FIG.", "8: depicts the results from expression experiments with of luciferase encoding mRNA according to SEQ ID NO: 369 in HeLa cells.", "As can be seen, formulations of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 with the PB83 polymer (molar ratio of RNA:PB83 1:50) lead to significant higher expression of luciferase compared to th free peptide combined with RNA in molar ratio 1:50 (e.g.", "template assisted polymerization in situ Rice et.", "Al.", "), to the non-pegylated polymerization product PB83 w/o PEG in molar ratio 1:50 (e.g.", "RPC conform), PB83 polymerization without peptide component (e.g.", "dimerized PEG-SS-PEG) and a non-reversible PEGylated of PB83 derivative which was synthesized by malimide containing PEG termination of the polymerization reaction.", "FIG.", "9A: illustrates the results from expression experiments with luciferase encoding mRNA according to SEQ ID NO: 369 in BALB/c mice after intradermal injection.", "As a result, formulation of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 with the PB19 polymer leads to expression of luciferase in the dermis of female BALB/c mice.", "Other transfection reagents known in the art (PEI and Lipofectamine 2000) did not show any expression of the Luciferase protein.", "FIG.", "9B: illustrates the results from expression experiments with luciferase encoding mRNA according to SEQ ID NO: 369 in BALB/c mice after intramuscular injection.", "As a result, formulation of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 with the PB19 polymer leads to expression of luciferase in the m. tibialis of female BALB/c mice.", "Other transfection reagents known in the art (PEI and Lipofectamine 2000) did not show any expression of the Luciferase protein.", "FIG.", "10: shows the expression of luciferase in BALB/c mice after intradermal injection of different formulations of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 with two different polymers according to the invention [PB19 and PB48].", "These formulations of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 with two different polymers according to the invention [PB19 and PB48] lead to expression of luciferase in the dermis of female BALB/c mice.", "The polymeric carrier cargo complex formed by a peptide according to RPC CH6R4H6C (without PEGylation) and mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 in a molar ratio of 2500:1 showed no expression of luciferase after intradermal injection of the complexed mRNA.", "FIG.", "11: shows the expression of luciferase in BALB/c mice after intradermal injection of different formulations of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 with three different polymers according to the invention [PB124, PB117 and PB83].", "These formulations lead all to an expression of luciferase in the dermis of female BALB/c mice.", "FIG.", "12: depicts the results from expression experiments with of luciferase encoding mRNA according to SEQ ID NO: 369 in CHO cells.", "As can be seen, formulations of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 with different polymers according to the invention (molar ratio of RNA:PB 1:250) all lead to high levels of luciferase expression in serum containing medium.", "Also the advantageous effect of the hydrophilic component AAx (in this case the peptide CAS3PS3AC in the polymer can easily be seen.", "FIG.", "13: depicts the secretion of hIL-6 cytokine in hPBMCs.", "It could be shown that complexes consisting of the polymers according to the invention (PB19 and PB22) and mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 do not induce the secretion of cytokines in hPBMCs in contrast to complexes consisting of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 and cationic peptides (H3R9H3) or a combination of cationic peptides (H3R9H3) and PEGylated cationic peptides (which confers in general to subsequent hydrophilic coating of pre-formed nucleic acid condensates).", "The polymers used were: E9-PEG5k: HO-PEG5000-EEEEEEEEE E9-PEG3k: HO-PEG3000-EEEEEEEEE R9-PEG3k: HO-PEG3000-RRRRRRRRR PB19: HO-PEG5000-S—(S—CHHHRRRRHHHC—S)5—S-PEG5000-OH PB22: HO-PEG5000-S—(S—CHHHHHHRRRRHHHHHHC—S)5—S-PEG5000-OH FIG.", "14: illustrates the secretion of hTNFa cytokine in hPBMCs.", "It could be shown that complexes consisting of the polymers according to the invention (PB19 and PB22) and mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 do not induce the secretion of cytokines in hPBMCs in contrast to complexes consisting of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 and cationic peptides (H3R9H3) or such complexes coated with PEGylated peptides (which confers in general to subsequent hydrophilic coating of pre-formed nucleic acid condensates).", "The polymers used were: E9-PEG5k: HO-PEG5000-EEEEEEEEE E9-PEG3k: HO-PEG3000-EEEEEEEEE R9-PEG3k: HO-PEG3000-RRRRRRRRR PB19: HO-PEG5000-S—(S—CHHHRRRRHHHC—S)5—S-PEG5000-OH PB22: HO-PEG5000-S—(S—CHHHHHHRRRRHHHHHHC—S)5—S-PEG5000-OH FIG.", "15: shows the secretion of hTFNa cytokine secretion in hPBMCs.", "It could be shown that complexes consisting of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 and polymers according to the invention (PB19) do not induce the secretion of hTFNa in hPBMCs in contrast to complexes consisting of mRNA coding for luciferase (luc-RNActive) according to SEQ ID NO: 369 and state of the art transfection reagents like Lipofectamin 2000.FIG.", "16: shows the mRNA sequence encoding Photinus pyralis luciferase (SEQ ID NO: 369) in the mRNA construct pCV19-Pp luc(GC)-muag-A70-C30; which exhibits a length of 1857 nucleotides.", "The mRNA sequence contains following sequence elements: the coding sequence encoding Photinus pyralis luciferase; stabilizing sequences derived from alpha-globin-3′-UTR (muag (mutated alpha-globin-3′-UTR)); 70× adenosine at the 3′-terminal end (poly-A-tail); 30× cytosine at the 3′-terminal end (poly-C-tail).", "The ORF is indicated in italic letters, muag (mutated alpha-globin-3′-UTR is indicated with a dotted line, the poly-A-tail is underlined with a single line and the poly-C-tail is underlined with a double line.", "EXAMPLES The following examples are intended to illustrate the invention further.", "They are not intended to limit the subject matter of the invention thereto.", "1.Preparation of DNA and mRNA Constructs Encoding Pp Luciferase (Photinus pyralis) For the present examples DNA sequences, encoding Photinus pyralis luciferase, were prepared and used for subsequent in vitro transcription reactions.", "According to a first preparation, the DNA sequence termed pCV19-Ppluc(GC)-muag-A70-C30 sequence was prepared, which corresponds to the Photinus pyralis luciferase coding sequence.", "The construct was prepared by modifying the wildtype Photinus pyralis luciferase encoding DNA sequence by introducing a GC-optimized sequence for a better codon usage and stabilization, stabilizing sequences derived from alpha-globin-3′-UTR (muag (mutated alpha-globin-3′-UTR)), a stretch of 70× adenosine at the 3′-terminal end (poly-A-tail) and a stretch of 30× cytosine at the 3′-terminal end (poly-C-tail), leading to SEQ ID NO: 369 (see FIG.", "16).", "The sequence of the final DNA construct had a length of 1857 nucleotides and was termed “pCV19-Ppluc(GC)-muag-A70-C30”.", "In SEQ ID NO: 369 (see FIG.", "16) the sequence of the corresponding mRNA is shown.", "The sequence contains following sequence elements: the coding sequence encoding Photinus pyralis luciferase; stabilizing sequences derived from alpha-globin-3′-UTR (muag (mutated alpha-globin-3′-UTR)); 70× adenosine at the 3′-terminal end (poly-A-tail); 30× cytosine at the 3′-terminal end (poly-C-tail).", "2.In Vitro Transcription: The respective DNA plasmid prepared according to Example 1 was transcribed in vitro using T7-Polymerase.", "Subsequently the mRNA was purified using PureMessenger® (CureVac, Tuibingen, Germany).", "3.Reagents: Peptides: The peptides used in the present experiments were as follows: PB 19: HO-PEG5000-S—(S—CHHHRRRRHHHC—S)s-S-PEG5000-OH (pegylated CH3R4H3C peptide polymer) PB22: HO-PEG5000-S—(S—CHHHHHHRRRRHHHHH HC—S)5—S-PEG5000-OH (pegylated CH6R4H6C peptide polymer) PB48: HO-PEG5000-S—(S—CHHHRRRRHHHC—S)3—S-PEG5000-OH PB83: HO—PEG5000-S—(S— CHHHHHHRRRRHHHHHHC—S—)7-S— PEG5000-OH PB86: HO— PEG5000-S—(S—CHHHHHHRRRRHHHHHHC—S—)(S-CAS3PS3AC-S)5—S— PEG5000-OH PB117 HO— PEG5000-S—(S— CHKKKKKKHC—S—)7-S— PEG5000-OH PB124 HO— PEG2000-S—(S— CHHHHHHRRRRHHHHHHC—S—)7-S— PEG2000-OH PB83 free peptide HS—(CHHHHHHRRRRHHHHHHC)—SH freshly solved in water prior formulation PB83 w/o peptide PEG-SS-PEG PB83 w/o PEG HS—(CHHHHHHRRRRHHHHHHC)n—SH PB83malPEG PEG-mal-(S— CHHHHHHRRRRHHHHHHC—S—)x-mal-PEG H3R9H3: HHHRRRRRRRRRHHH CH6R4H6C: H—(S—CHHHHHHRRRRHHHHHHC—S)5—H Further Transfection Reagents Used are: Lipofectamine 2000 (Invitrogen) PEI 25 kDa (branched) (Aldrich) 4.Synthesis of the Inventive Polymeric Carrier: The condensation reaction was performed with the calculated amount of peptide (component P2) which is dissolved in a mixture of a buffered aqueous solution at pH 8.5 with an optional additive of 5% (v/v) Dimethylsulfoxide (DMSO) (which are mild oxidation conditions and therefore allow the establishment of an equilibrium) and stirred for 18 h at ambient temperature.", "Afterwards the calculated amount of a thiol group containing PEG derivative (alpha-Methoxy-omega-mercapto poly(ethylene glycol)) (component P1) (dissolved in water) is added and the resulting solution is stirred for another 18 h. Subsequent lyophilisation and purification yield the desired polymer.", "The ratio between PEG component P1 to peptide component P2 defines the chain length of the P2 polymer.", "The condensation reaction in this reaction environment is reversible, therefore the chain length of the polymer is determined by the amount of the monothiol compound which terminates the polymerisation reaction.", "In summary the length of the polymer chain is determined by the ratio of oligo-peptide and monothiol component.", "This reaction is supported by the chosen mild oxidation conditions.", "With more stringent oxidation conditions (30% DMSO) the generation of high molecular (long chain) polymers is induced.", "4.1.1.Step: Exemplary Polymerization Reaction: n HS—CHHHRRRHHHC—SH→H—(S—CHHHRRRRHHHC—S)n—H 4.2.2.Step: Exemplary Stop Reaction: H—(S—CHHHRRRRHHHC—S)n—H+2 PEG-SH→PEG-S—(S—CHHHRRRRHHHC—S)n—S-PEG 4.3.Exemplary Synthesis Reaction: step 1) 5×HS—CHHHRRRHHHC—SH→H—(S—CHHHRRRRHHHC—S)5—H step 2) H—(S—CHHHRRRRHHHC—S)5—H+2×PEG5000-SH→PEG5000-S—(S—CHHHRRRRHHHC—S)s-S-PEG5000 To achieve a polymer length of 5 (n=5), a molar ratio of peptide:PEG of 5:2 was used.", "Some variations of the synthesis reaction were done to show the the effect of the PEGchains and the effects of the reversible attachment of the PEG chains.", "4.4.Synthesis Reaction for Polymeric Carriers without PEG Chains: The reaction conditions are the same as mentioned above, but the step of the addition of a sulfhydryl containing PEG derivative is not performed/skipped.", "4.5.Synthesis Reaction for Irreversible Attached PEG Chains: The reaction conditions are the same as mentioned above, but instead of a sulfhydryl containing PEG derivative a maleimide containing PEG derivative is utilized.", "The maleimide moiety reacts rapidly with free sulfhydryl groups forming a covalent bond.", "Therefore the termination of the polymerization is not under the dynamic equilibria conditions as for sulfhydryl containing PEG derivatives but under irreversible conditions which results in a “frozen” polymerization pattern of high polydiversity and not the defined reaction products of the dynamic equilibria reaction.", "5.Complexation of RNA: The mRNA construct defined above in Example 1 and prepared according to Example 2, were complexed for the purposes of the present invention with the polymers, preferably as defined in Example 4.Therefore, 4 μg RNA coding for luciferase pCV19-Ppluc(GC)-muag-A70-C30 (Luc-RNActive) according to SEQ ID NO: 85 were mixed in molar ratios as indicated with the inventive polymeric carrier (according to formula I) or a control, thereby forming a complex.", "Afterwards the resulting solution was adjusted with water to a final volume of 50 μl und incubated for 30 minutes at room temperature.", "The different inventive polymeric carriers and the different ratios of polymeric carriers/RNA used in this experiment are shown in table 1.Cationic Präfix Polymer Ratio AS N/P PB19 HO-PEG5000-S-(S-CHHHRRRRHHHC-S)5-S-PEG5000-OH 500 20 5, 6 PB19 HO-PEG5000-S-(S-CHHHRRRRHHHC-S)5-S-PEG5000-OH 250 20 2, 8 PB19 HO-PEG5000-S-(S-CHHHRRRRHHHC-S)5-S-PEG5000-OH 50 20 0, 6 PB48 HO-PEG5000-S-(S-CHHHRRRRHHHC-S)3-S-PEG5000-OH 250 12 1, 67 PB76 HO-PEG5000-S-(S-CHHHHHHRRRRHHHHHHC-S)10-S-PEG5000-OH 500 40 11, 2 PB76 HO-PEG5000-S-(S-CHHHHHHRRRRHHHHHHC-S)10-S-PEG5000-OH 250 40 5, 6 PB76 HO-PEG5000-S-(S-CHHHHHHRRRRHHHHHHC-S)10-S-PEG5000-OH 50 40 1, 1 PB83 HO-PEG5000-S-(S-CHHHHHHRRRRHHHHHHC-S)7-S-PEG5000-OH 250 28 2, 8 PB86 HO-PEG5000-S-(S-CHHHHHHRRRRHHHHHHC-S-)5(S-CAS3PS3AC- 250 20 2, 8 S)5-S-PEG5000-OH Ratio = molar ratio of RNA:peptide cationic AS = cationic amino acids, which are positively charged at a physiological pH (i.e.", "not histidine (H) but e.g.", "arginine (R)) Whereas PB83 and PB86 have a cationic insert that is double in size compared to PB19, therefore has double as much cationic amino acid residues.", "PB48 has a shorter cationic insert compared to PB19, therefore has less cationic amino acid residues per molecule polymer.", "N/P = is the ratio of basic nitrogen atoms in the polymeric carrier to phosphate residues in the nucleic acid, considering that nitrogen atoms confer to positive charges and phosphate of the phosphate backbone of the nucleic acid confers to the negative charge.", "Histidine residues are counted neutral, because complex formation is done at physiological pH, therefore the imidazole residue is uncharged.", "N/P is calculated by the following formula: N  /  P = pmol  [ RNA ] * ratio * cationic   AS µg   RNA * 3 * 1000 For the calculations RNA coding for luciferase pCV19-Ppluc(GC)-muag-A70-C30 (Luc-RNActive) according to SEQ ID NO: 369 was applied, which has a molecular weight of 660 kDa.", "Therefore 1 μg pCV19-Ppluc(GC)-muag-A70-C30 RNA according to SEQ ID NO: 369 confers to 1.67 pmol pCV19-Ppluc(GC)-muag-A70-C30 RNA according to SEQ ID NO: 369 6.Size and Zetapotential Measurements: The hydrodynamic diameters of polyplexes as prepared above were measured by dynamic light scattering using a Zetasizer Nano (Malvern Instruments, Malvern, UK) according to the SOPs distributed by Malvern.", "The measurements were performed at 25° C. in the specified buffer analysed by a cumulant method to obtain the hydrodynamic diameters and polydispersity indices of the polyplexes.", "The Zeta potential of the polyplexes was evaluated by the laser Doppler electrophoresis method using a Zetasizer Nano (Malvern Instruments, Malvern, UK).", "The measurement was performed at 25° C. and a scattering angle of 173° was used.", "7.Gel Shift Assay Furthermore, mRNA coding for luciferase (Luc-RNActive) according to SEQ ID NO: 369 was formulated with the polymers as indicated and aliquots were incubated with either heparin (100 μg) or Dithiothreitol (DTT) for 15 Minutes at 37° C. Afterwards electrophoresis was done on agarose gel and the nucleic acids were visualized by ethidium bromide staining.", "8.Confocal Laser Scanning Microscopy Confocal laser scanning microscopy was performed on an inverted LSM510 laser scanning microscope (Carl Zeiss, Germany) using a Plan-Apochromat 63x/1.4 N.A.", "lens.", "All analyses were performed with living, nonfixed cells grown in eight-well chambered cover slides (Nunc, Germany).", "For the detection of Alexa Fluor 647 labelled mRNA only the light of a 633-nm helium neon laser, directed over a UV/488/543/633 beam splitter in combination with a LP 650 long pass filter was used.", "Life cell microscopy was performed at room temperature.", "For this purpose, L929 cells (25×103/well) were seeded 1 day prior to transfection on 24-well microtiter plates leading to a 70% confluence when transfection was carried out.", "Cells were transfected with formulations containing 2 μg Alexa Fluor 647 labelled mRNA in 8 chamber well slides directly before conduction of the microscopy experiment.", "8.Cytokinstimulation in hPBMC HPBMC cells from peripheral blood of healthy donors were isolated using a Ficoll gradient and washed subsequently with 1×PBS (phophate-buffered saline).", "The cells were then seeded on 96-well microtiter plates (200×103/well).", "The hPBMC cells were incubated for 24 h with 10 μl of the RNA/carrier complex in X-VIVO 15 Medium (BioWhittaker).", "As RNA SEQ ID NO: 369 was used.", "The carriers were as shown above for generic formula (I).", "The immunostimulatory effect upon the hPBMC cells was measured by detecting the cytokine production (Interleukin-6; Tumor necrose factor alpha, Interferon alpha).", "Therefore, ELISA microtiter plates (Nunc Maxisorb) were incubated over night (o/n) with binding buffer (0.02% NaN3, 15 mM Na2CO3, 15 mM NaHCO3, pH 9.7), additionally containing a specific cytokine antibody.", "Cells were then blocked with 1×PBS, containing 1% BSA (bovine serum albumin).", "The cell supernatant was added and incubated for 4 h at 37° C. Subsequently, the microtiter plate was washed with 1×PBS, containing 0.05% Tween-20 and then incubated with a Biotin-labelled secondary antibody (BD Pharmingen, Heidelberg, Germany).", "Streptavidin-coupled horseraddish peroxidase was added to the plate.", "Then, the plate was again washed with 1×PBS, containing 0.05% Tween-20 and ABTS (2,2′-azino-bis(3-ethyl-benzthiazoline-6-sulfonic acid) was added as a substrate.", "The amount of cytokine was determined by measuring the absorption at 405 nm (OD 405) using a standard curve with recombinant cytokines (BD Pharmingen, Heidelberg, Germany) with the Sunrise ELISA-Reader from Tecan (Crailsheim, Germany).", "9.Transfection of HeLa Cells: 4 μg RNA stabilized luciferase mRNA (Luc-RNActive) according to SEQ ID NO: 85 were mixed in molar ratios as indicated with the respective polymer (according to formula I), thereby forming a complex.", "Afterwards the resulting solution was adjusted with water to a final volume of 50 μl und incubated for 30 minutes at room temperature.", "The used ratios are indicated in table 1 above.", "Hela-cells (150×103/well) were seeded 1 day prior to transfection on 24-well microtiter plates leading to a 70% confluence when transfection was carried out.", "For transfection 50 μl of the RNA/carrier complex solution were mixed with 250 μl serum free or FCS containing medium (as indicated in the provided table) and added to the cells (final RNA concentration: 13 μg/ml).", "Prior to addition of the serum free transfection solution the HeLa-cells were washed gently and carefully 2 times with 1 ml Optimen (Invitrogen) per well.", "Then, the transfection solution (300 μl per well) was added to the cells and the cells were incubated for 4 h at 37° C. Subsequently 300 μl RPMI-medium (Camprex) containing 10% FCS was added per well and the cells were incubated for additional 20 h at 37° C. The transfection solution was sucked off 24 h after transfection and the cells were lysed in 300 μl lysis buffer (25 mM Tris-PO4, 2 mM EDTA, 10% glycerol, 1% Triton-X 100, 2 mM DTT).", "The supernatants were then mixed with luciferin buffer (25 mM Glycylglycin, 15 mM MgSO4, 5 mM ATP, 62.5 μM luciferin) and luminiscence was detected using a luminometer (Lumat LB 9507 (Berthold Technologies, Bad Wildbad, Germany)).", "10.Expression of Luciferase In Vivo 10 μg mRNA coding for luciferase (Luc-RNActive) according to SEQ ID NO: 369 were mixed in a molar ratio of 1:250 (RNA:polymeric carrier) with the respective carrier (according to formula I), thereby forming a complex.", "Afterwards the resulting solution was adjusted with Ringer Lactate solution to a final volume of 100 μl und incubated for 30 minutes at room temperature, yielding a solution with a 0.1 g/l concentration of complexed RNA.", "100 μl (20 μl) of this solution was administrated intradermally (ear pinna or back) or intramuscularly (m. tibialis) to 7 week old BALB/c mice.", "After 24 h the mice were sacrificed and the samples (ear, skin from the back or muscle) were collected, frozen at −78° C. and lysed for 3 Minutes at full speed in a tissue lyser (Qiagen, Hilden, Germany).", "Afterwards 600 μl of lysis buffer were added and the resulting solutions were subjected another 6 minutes at full speed in the tissue lyser.", "After 10 minutes centrifugation at 13500 rpm at 4° C. the supernatants were mixed with luciferin buffer (25 mM Glycylglycin, 15 mM MgSO4, 5 mM ATP, 62.5 μM luciferin) and luminiscence was detected using a luminometer (Lumat LB 9507 (Berthold Technologies, Bad Wildbad, Germany)).", "11.Results: 11.1.DLS/Zetasizer Determinations: The size and ζ-potential of the polymeric carrier cargo complexes according to the invention were evaluated in triplicates by dynamic light scattering (DLS) and laser-doppler electrophoresis and compared to different polymeric carrier cargo complexes known in the state of the art.", "Table 1 summarizes the cumulant diameters and the ζ-potential of the polymeric carrier cargo complexes.", "Cumulant Cumulant Polymeric carrier diameter in diameter in ringer ζ-potential cargo complex N/P water (nm) lactate (nm) (mV) PB19 6 58 ± 2 81 ± 3 −9 mV PEI 10 88 ± 4 110 ± 2 +20 mV RPC like 5 170 ± 8 >1000 +39 mV polymer CH6R4H6C The cumulant diameters of the polymeric carrier cargo complexes formed by polymers according to the invention and mRNA coding for luciferase (Luc-RNActive) according to SEQ ID NO: 369 showed that small, uniform complexes were formed.", "These complexes are stable against agglomeration in salt containing buffer and are less than 100 nm in size.", "In contrast polymeric carrier cargo complexes according to the RPC procedure are unstable in salt containing buffers, forming large aggregates.", "The polymeric carrier cargo complexes according to the invention also form complexes of low ζ-potential, which is linked to a low tendency in binding components of the serum, and therefore have a low tendency for opsonisation.", "11.2.Confocal Microscopy: The transfection of L929 cells with AlexaFlour647 aminoallyl-labelled RNA complexed with the inventive polymer PB19 after 5 minutes already led to detectable complexes in the cell.", "The results are shown in FIGS.", "2 and 3.As can be seen in FIG.", "2, confocal microscopy of L929 cells 5 minutes after transfection with fluorescence labelled RNA (SEQ ID NO: 369) complexed with the inventive polymer PB19 in a molar ratio of 1:500 showed that already 5 minutes after transfection several complexes are detectable in the cells.", "After h confocal microscopy of L929 cells h after transfection with fluorescence labelled RNA complexed with the inventive polymer PB19 in a ratio of 1:500 revealed that after transfection most of the particles were taken up in the cells (see FIG.", "3) 11.3.Stability Towards Electrostatic Displacement: Since the complexes of the present invention, particularly the polymers according to formula (I) are unique with respect to their composition and their surface charge, unexpected results could be observed in gel shift assays.", "Normally, it is determined, as to whether a polymer condenses the nucleic acid and thus prevents the nucleic acid to migrate in an electrical field.", "If a complex partner is added, which exhibits a stronger affinity for the cationic polymer than the nucleic acid, the nucleic acid is displaced from the complex and again can migrate in an electrical field.", "For this purpose, PEI may be used, which is known to exhibit extremely strong complexes with nucleic acid.", "In a gel shift assay to examine the strength of complex binding (see FIG.", "4) it could be shown that the addition of the anionic polymer heparin can not displace the RNA from the inventive polymeric carrier cargo complex because it still migrates in the gel.", "This indicates that the complex binding is so strong that a competitive complex partner cannot displace the RNA from the inventive polymeric carrier cargo complex.", "In a further a gel shift assay to examine the strength of complex binding (see FIG.", "5) it could be shown that the addition of the anionic polymer heparin or the reducing agent DTT alone cannot display the RNA from the inventive polymeric carrier cargo complex with the polymer according to the invention (PB19).", "Only together they are able to display the RNA from the complex (lane 7).", "This indicates that the complex binding is so strong that neither a competitive complex partner nor a reducing agent can displace the RNA from the inventive polymeric carrier cargo complex.", "Contrary to PEI complexes, the RNA is not released from the inventive polymeric carrier cargo complex upon addition of heparin.", "Only a combination of heparin and DTT releases the RNA.", "It is to be noted that DTT reduces disulfide bonds and thus destroys the conjugate.", "This imitates in vivo conditions, where the reducing conditions in the cell releases the RNA from the complex.", "In comparison thereto, gel shift assays with PEI complexes to examine the strength of complex binding show that the addition of the anionic polymer heparin alone cannot displace the RNA from the complex with polymers used according to the present invention (PB22).", "In contrast mRNA could be readily displayed by heparin from PEI complexes (see FIG.", "6).", "11.4.Expression of Luciferase in HeLa Cells: The expression of luciferase in HeLa cells was determined using a complex of a polymer according to formula (I) herein and an mRNA according to SEQ ID NO: 369 (mRNA coding for luciferase (luc-RNActive) with the PB19 carrier (molar ratio of RNA:PB19 1:1000, 1:500, 1:100).", "These formulations of mRNA coding for luciferase (luc-RNActive) with the PB19 carrier (molar ratio of RNA:PB19 1:1000, 1:500, 1:100) lead to expression of luciferase independently of the presence of serum containing medium.", "These results are unexpected because serum containing medium leads in general to a loss of transfection efficiency.", "11.5.Expression of Luciferase In Vivo Expression of luciferase in BALB/c mice was determined after intradermal injection.", "As can be seen in FIG.", "9a, formulations of mRNA coding for luciferase (luc-RNActive) (SEQ ID NO: 369) with the PB19 polymer lead to expression of luciferase in the dermis of female BALB/c mice.", "Other transfection reagents known in the art (PEI and Lipofectamine 2000) did not show any expression of the Luciferase protein.", "Furthermore, expression of luciferase in BALB/c mice after intramuscular injection was determined.", "As a result (see FIG.", "9b), formulations of mRNA coding for luciferase (luc-RNActive) (SEQ ID NO: 369) with the PB19 polymer lead to expression of luciferase in the m. tibialis of female BALB/c mice.", "Other transfection reagents known in the art (PEI and Lipofectamine 2000) did not show any expression of the Luciferase protein.", "Additionally, expression of luciferase in BALB/c mice after intradermal injection of different formulations was determined.", "As a result (see FIG.", "10), formulations of mRNA coding for luciferase (luc-RNActive) (SEQ ID NO: 369) with two different polymers according to the present invention (polymers PB19 and PB48) lead to expression of luciferase in the dermis of female BALB/c mice.", "The polymeric carrier cargo complex formed by a peptide according to RPC CH6R4H6C (without PEGylation) and RNA in a molar ratio of 2500:1 procedure showed no expression of luciferase after intradermal injection of the complexed RNA.", "11.6 Cytokine Stimulation in hPBMC Cytokine stimulation, particularly hIL-6 cytokine secretion in hPBMCs was measured.", "As a result (see FIG.", "13) it could be shown that the complexes according to the invention consisting of RNA (SEQ ID NO: 369) and polymers according to the invention (PB19 and PB22) do not induce the secretion of hIL-6 in hPBMCs in contrast to complexes consisting of RNA (SEQ ID NO: 369) and cationic peptides (H3R9H3) or a combination of cationic peptides (H3R9H3) and PEGylated peptides (E9 or R9) (which confers in general to subsequent hydrophilic coating of pre-formed nucleic acid condensates).", "E9-PEG5k: HO-PEG5000-EEEEEEEEE E9-PEG3k: HO-PEG3000-EEEEEEEEE R9-PEG3k: HO-PEG3000-RRRRRRRRR PB19: HO-PEG5000-S—(S—CHHHRRRRHHHC—S)5—S-PEG5000-OH PB22: HO-PEG5000-S—(S—CHHHHHHRRRRHHHHHHC—S)5—S-PEG5000-OH Furthermore, hTNFα cytokine secretion in hPBMCs was measured.", "The results show (see FIG.", "14), that the complexes according to the invention consisting of RNA (SEQ ID NO: 369) and polymers according to the invention (PB19 and PB22) do not induce the secretion of hTNFα in hPBMCs in contrast to complexes consisting of RNA (SEQ ID NO: 369) and cationic peptides (H3R9H3) or such complexes coated with PEGylated peptides (E9 or R9) (which confers in general to subsequent hydrophilic coating of pre-formed nucleic acid condensates).", "E9-PEG5k: HO-PEG5000-EEEEEEEEE E9-PEG3k: HO-PEG3000-EEEEEEEEE R9-PEG3k: HO-PEG3000-RRRRRRRRR PB19: HO-PEG5000-S—(S—CHHHRRRRHHHC—S)5—S-PEG5000-OH PB22: HO-PEG5000-S—(S—CHHHHHHRRRRHHHHHHC—S)5—S-PEG5000-OH Moreover, hIFNa cytokine secretion in hPBMCs was determined in a comparison of cytokine stimulating properties of complexes according to the invention consisting of RNA (SEQ ID NO: 369) and polymers according to the invention (PB19) to state of the art transfection reagents like Lipofectamin 2000 or PEI.", "As a result both Complexation with Lipofectamin 2000 and PEI lead to a high amount of secretion of hIFNa, whereas the complex according to the invention consisting of RNA (SEQ ID NO: 369) and polymers according to the invention (PB19 500) did not.", "Furthermore, hTNFα cytokine secretion in hPBMCs was measured in a comparison of cytokine stimulating properties of complexes according to the invention consisting of RNA (SEQ ID NO: 369) and polymers according to the invention (PB19) to state of the art transfection reagents like Lipofectamin 2000 or PEI.", "As a result (see FIG.", "15) Complexation with Lipofectamine 2000 leads to a high amount of secretion of hTNFα, whereas complexation with PEI or polymers according to the invention (PB19 500) did not." ] ]
Patent_15874338
[ [ "ON-LINE ADVERTISEMENT METHOD USING ADVERTISEMENT WEBSITE", "Disclosed is an on-line advertisement method using an advertisement website.", "An on-line advertisement method according to an embodiment of the present invention provides an advertisement available to a user terminal at a current position of a user terminal which accesses an advertisement website." ], [ "1.An on-line advertisement method using an advertisement website, comprising: accessing to an advertisement website in which advertisements of each area are posted, using a user terminal; providing an advertisement image to the user terminal so that a local selection menu for selecting at least one of an area to which the user terminal is accessed and an upper area on an administrative region including the accessed area, and the advertisement image including the advertisements are displayed on the user terminal; when a signal notifying that a specific area is selected is received from the user terminal via the local selection menu, searching for advertisements related to the selected specific area among the advertisements registered in the advertisement website; and providing a limited number of advertisements among the searched advertisements to the user terminal for the designated time such that a limited number of advertisements among the searched advertisements are displayed on a screen of the user terminal for the time designated for each advertisement.", "2.The on-line advertisement method of claim 1, further comprising: moving and posting the advertisements displayed on the advertisement image to upper area of the administrative region on which the advertisement is posted when the number of viewing time or preference of other users increases beyond a reference value.", "3.An on-line advertisement method, comprising: accessing to an advertisement website in which advertisements of each are posted using a user terminal; providing the advertisement image to the user terminal so that a local selection menu for selecting at least one of an area to which the user terminal is accessed and an upper area on an administrative region including the accessed area, and the advertisement image including the advertisements are displayed on the user terminal; searching for an advertisement to which the same hashtag as a keyword input by the user in advance among the advertisements registered on the advertisement website, when a signal notifying that a specific area is selected is received from the user terminal through the local selection menu; and coloring and displaying a background color or a frame color of an advertisement to which the same hashtag as the keyword input by the user in advance by an arbitrary color.", "4.The on-line advertisement method of claim 1, wherein the number of advertisements displayed on the advertisement image decrease as the area selected by the local selection menu is an upper area, and the number of advertisements displayed on the advertisement image increases as the selected areas is a lower area.", "5.The on-line advertisement method of claim 1, wherein a posting retention time of the advertisements displayed on the advertisement image becomes shorter as the areas selected through the local selection menu is a lower area.", "6.The on-line advertisement method of claim 1, wherein the advertisement contents of the advertisements displayed on the advertisement image are gradually summarized and displayed as the area selected through the local selection menu is a lower area.", "7.The on-line advertisement method of claim 1, wherein the advertisement image further includes a bulletin board on which the advertisements for paying points to the user terminal are posted, when the user terminal selects an advertisement of another subscriber, and the user terminal is capable of posting a free advertisement on the bulletin board by utilizing the paid points.", "8.The on-line advertisement method of claim 7, further comprising: purchasing an area for posting advertisement in the advertisement image, a posting time, and a position in the advertisement image by auction, using the points paid to the user terminal, wherein, when the points are insufficient, by purchasing the points by cash or by receiving points of other users, the area for posting the advertisement, the posting time, and the position of the advertisement image are purchased by auction.", "9.The on-line advertisement method of claim 7, wherein the points paid by the advertisement related to the upper area are larger than the points paid by the advertisement related to the lower area.", "10.An on-line advertisement method comprising: receiving an input of at least one keyword from a user; searching for an advertisement to which the same hashtag as the keyword is added among a plurality of advertisements registered on a website; and displaying the searched advertisement on a dedicated bulletin board capable of being checked only by the user.", "11.The on-line advertisement method of claim 10, further comprising: generating a message to be sent to another subscriber registered as a friend with the user; searching for an advertisement matching the keyword registered by the another subscriber in the message; and adding the detected advertisement to the message.", "12.The on-line advertisement method of claim 1, wherein the advertisement is for notifying other users of at least one of a specific product, a specific government agency, a specific person, news, and contents.", "13.The on-line advertisement method of claim 3, wherein the number of advertisements displayed on the advertisement image decrease as the area selected by the local selection menu is an upper area, and the number of advertisements displayed on the advertisement image increases as the selected areas is a lower area.", "14.The on-line advertisement method of claim 3, wherein a posting retention time of the advertisements displayed on the advertisement image becomes shorter as the areas selected through the local selection menu is a lower area.", "15.The on-line advertisement method of claim 3, wherein the advertisement contents of the advertisements displayed on the advertisement image are gradually summarized and displayed as the area selected through the local selection menu is a lower area.", "16.The on-line advertisement method of claim 3, wherein the advertisement image further includes a bulletin board on which the advertisements for paying points to the user terminal are posted, when the user terminal selects an advertisement of another subscriber, and the user terminal is capable of posting a free advertisement on the bulletin board by utilizing the paid points.", "17.The on-line advertisement method of claim 16, further comprising: purchasing an area for posting advertisement in the advertisement image, a posting time, and a position in the advertisement image by auction, using the points paid to the user terminal, wherein, when the points are insufficient, by purchasing the points by cash or by receiving points of other users, the area for posting the advertisement, the posting time, and the position of the advertisement image are purchased by auction.", "18.The on-line advertisement method of claim 16, wherein the points paid by the advertisement related to the upper area are larger than the points paid by the advertisement related to the lower area.", "19.The on-line advertisement method of any one of claim 3, wherein the advertisement is for notifying other users of at least one of a specific product, a specific government agency, a specific person, news, and contents.", "20.The on-line advertisement method of any one of claim 10, wherein the advertisement is for notifying other users of at least one of a specific product, a specific government agency, a specific person, news, and contents." ], [ "<SOH> BACKGROUND <EOH>Generally, an advertisement is a one-way communication with the aim of notifying potential consumers of information on products and services and purchasing methods, and has an object of directly reaching sales, that is, a commercial purpose.", "Furthermore, a public relation is a propaganda by which a government agencies, companies, organizations, or individuals widely notify the purpose of business in order to obtain public confidence and understanding and attract attention, and has an object of constructing images and obtain awareness and preference, that is, a non-commercial purpose.", "At the present day, a lot of candidates and information emerge in various media and global society, and among them, the acts of notifying themselves or their wills become increasingly intense.", "Accordingly, a public relation is comparatively lower in cost than the advertisement, it is required to make advertisement incurring a great expense in order to have a republic relation effect for people.", "However, these advertisements have many problems.", "There are problems in which, in the case of an advertiser, on-line or offline media with high advertising effectiveness has higher advertisement cost, it is difficult to know how advertisement effect occurs, and the recognition of the advertisement disappears from the consumers after the end of the advertisement contract.", "Also, from the viewpoint of consumers who watch the advertisements, they don't like advertisements that are unnecessary to themselves or not interested, and there is a problem of distrust of advertisement thought as exaggerative advertisement.", "Furthermore, there is also a problem that advertisements that have spent a lot of expenses and research by companies and individuals are not utilized as another valuable information besides temporary public relation means." ], [ "<SOH> SUMMARY <EOH>An object of the present invention provides an on-line advertisement method using an advertisement website that provides advertisements of areas corresponding to an access position of a current user terminal when the user terminal is accessed to an advertisement website which offers advertisements for each area.", "The objects to be solved by the present invention are not limited to the objects mentioned above but other objects which have not been mentioned can be clearly understood by a person with knowledge in the technical field to which the invention pertains from the description below.", "A method for on-line advertisement using an advertisement website according to the present invention for achieving the above object includes accessing to an advertisement website in which advertisements of each area are posted, using a user terminal; providing the advertisement image to the user terminal so that a local selection menu for selecting at least one of an area to which the user terminal is accessed and at least one upper area including the accessed area, and an advertisement image including the advertisements are displayed on the user terminal; when a signal notifying that a specific area is selected is received from the user terminal via the local selection menu, searching for advertisements related to the selected specific area among the advertisements registered in the advertisement website; and providing searched advertisements to the user terminal for the designated time such that the searched advertisements are displayed on a screen of the user terminal for the time designated for each advertisement.", "The on-line advertisement method using the advertisement website according to the present invention has an effect of providing advertisements available to the user terminal at the current position of the user terminal accessing the advertisement website, thereby providing advertisements that are substantially available at the current position to the user of the website." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation application of international application PCT/KR2016/008272, filed on Jul.", "28, 2016, now pending, which claims priority from both Korean Patent Application No.", "10-2016-0092184 filed on Jul.", "20, 2016 in the Korean Intellectual Property Office, and from Korean Patent Application No.", "10-2015-0107034 filed on Jul.", "29, 2015 in the Korean Intellectual Property Office, the contents of each are herein wholly incorporated by reference.", "FIELD The present invention relates to an on-line advertisement method, and more particularly, to an on-line advertisement method using an advertisement website.", "BACKGROUND Generally, an advertisement is a one-way communication with the aim of notifying potential consumers of information on products and services and purchasing methods, and has an object of directly reaching sales, that is, a commercial purpose.", "Furthermore, a public relation is a propaganda by which a government agencies, companies, organizations, or individuals widely notify the purpose of business in order to obtain public confidence and understanding and attract attention, and has an object of constructing images and obtain awareness and preference, that is, a non-commercial purpose.", "At the present day, a lot of candidates and information emerge in various media and global society, and among them, the acts of notifying themselves or their wills become increasingly intense.", "Accordingly, a public relation is comparatively lower in cost than the advertisement, it is required to make advertisement incurring a great expense in order to have a republic relation effect for people.", "However, these advertisements have many problems.", "There are problems in which, in the case of an advertiser, on-line or offline media with high advertising effectiveness has higher advertisement cost, it is difficult to know how advertisement effect occurs, and the recognition of the advertisement disappears from the consumers after the end of the advertisement contract.", "Also, from the viewpoint of consumers who watch the advertisements, they don't like advertisements that are unnecessary to themselves or not interested, and there is a problem of distrust of advertisement thought as exaggerative advertisement.", "Furthermore, there is also a problem that advertisements that have spent a lot of expenses and research by companies and individuals are not utilized as another valuable information besides temporary public relation means.", "SUMMARY An object of the present invention provides an on-line advertisement method using an advertisement website that provides advertisements of areas corresponding to an access position of a current user terminal when the user terminal is accessed to an advertisement website which offers advertisements for each area.", "The objects to be solved by the present invention are not limited to the objects mentioned above but other objects which have not been mentioned can be clearly understood by a person with knowledge in the technical field to which the invention pertains from the description below.", "A method for on-line advertisement using an advertisement website according to the present invention for achieving the above object includes accessing to an advertisement website in which advertisements of each area are posted, using a user terminal; providing the advertisement image to the user terminal so that a local selection menu for selecting at least one of an area to which the user terminal is accessed and at least one upper area including the accessed area, and an advertisement image including the advertisements are displayed on the user terminal; when a signal notifying that a specific area is selected is received from the user terminal via the local selection menu, searching for advertisements related to the selected specific area among the advertisements registered in the advertisement website; and providing searched advertisements to the user terminal for the designated time such that the searched advertisements are displayed on a screen of the user terminal for the time designated for each advertisement.", "The on-line advertisement method using the advertisement website according to the present invention has an effect of providing advertisements available to the user terminal at the current position of the user terminal accessing the advertisement website, thereby providing advertisements that are substantially available at the current position to the user of the website.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a schematic configuration diagram of on-line advertisement using an advertisement website according to an embodiment of the present invention; FIG.", "2 is a flowchart illustrating an on-line advertisement method using an advertisement website according to an embodiment of the present invention; and FIG.", "3 is an explanatory diagrams illustrating an on-line advertisement process using an advertisement website according to an embodiment of the present invention.", "FIG.", "4 is an explanatory diagrams illustrating an on-line advertisement process using an advertisement website according to an embodiment of the present invention.", "FIG.", "5 is an explanatory diagrams illustrating an on-line advertisement process using an advertisement website according to an embodiment of the present invention.", "FIG.", "6 is an explanatory diagrams illustrating an on-line advertisement process using an advertisement website according to an embodiment of the present invention.", "FIG.", "7 is an explanatory diagrams illustrating an on-line advertisement process using an advertisement website according to an embodiment of the present invention.", "FIG.", "8 is an explanatory diagrams illustrating an on-line advertisement process using an advertisement website according to an embodiment of the present invention.", "FIG.", "9 is an explanatory diagrams illustrating an on-line advertisement process using an advertisement website according to an embodiment of the present invention.", "DETAILED DESCRIPTION OF THE INVENTION The aforementioned objects, features and advantages will be more clearly understood from the following detailed description taken in conjunction with the accompanying drawings.", "Accordingly, those having ordinary knowledge will be able to easily carry out the technical idea of the present invention.", "In the description of the present invention, when it is determined that a specific explanation on known technique related to the present invention may unnecessarily obscure the gist of the present invention, a detailed description thereof will be omitted.", "FIG.", "1 is a schematic configuration diagram of an on-line advertisement using an advertisement website according to an embodiment of the present invention, which includes an advertisement website 200 on which advertisements of a large number of areas are posted, a user terminal 20 accessible to the advertisement website 200, an advertisement provider 30 of each region accessed to the advertisement website 200 through the user terminal 20 to post advertisements, an advertisement viewer 40 which accesses to the advertisement website 200 via the user terminal 20 to watch and use advertisements posted in each area, and an operator server 100 which manages and operates the advertisement website 200.At this time, the advertisement in the present invention means an act of making explanation, purchase information, public relations, or the like of at least one of a specific product, a specific government agency, a specific person, and contents.", "Surveys on specific themes may also be included in the above advertisements.", "That is, in the advertisement in the present invention may include an act in which the advertisement provider notifies the commercial situation, and all the acts of notifying the advertisement provider to others by news, SNS messenger, etc.", "may also be included in the advertisement.", "Further, the user terminal 20 may be accessed to an advertisement website 200 such as a computer, a laptop, a wired/wireless phone, a mobile terminal, and a smart phone, and all the electronic devices on which the application providing the advertisement website 200 can be installed and used may be included.", "In addition, the advertisement website 200 is served to the user terminal 20 in the wireless Internet or mobile Internet standard via the operator server 100, or can be installed and used in the subscriber terminal 20 in the form of application generated and managed by the operator server 100.Hereinafter, the present invention will be described in detail with reference to FIGS.", "2 to 9.Referring to FIGS.", "2 to 9, when the operator server 100 detects that the user terminal 20 is accessed to the advertisement website 200 (S110), the operator server 100 provides the advertisement image to the user terminal 20 such that the local selection menu for selecting at least one of the area to which the user terminal 20 is accessed and at least one upper area including the accessed area, and an advertisement image including the advertisement are displayed on the user terminal 20.In other words, as illustrated in FIGS.", "3 to 9, the advertisement image provided to the user terminal 20 is a configuration of advertisement webpage 200 displayed on the screen of the user terminal 20.The operator server 100 grasps an area in which the user terminal 20 is accessed to the advertisement website 200, generates the advertisement website 200 including the local selection menu 300 capable of selecting two or more areas including the gasped area, an advertisement display region 400 in which the advertisements are displayed, and a bulletin board region 500 including the bulletin boards of various purposes in the advertisement website 200, and sends the generated advertisement website 200 to the user terminal 20 so that the accessed user terminal 20 is displayed.", "Further, if the signal notifying selection of a specific area is received from the user terminal 20 accessed to the advertisement website 200, via the local selection menu 300 (S130), the operator server 100 searches the advertisements related to the specific area corresponding to the signal among the advertisements registered in the current advertisement website 200 (S140).", "At this time, the advertisements related to the specific area may include at least one of the advertisement posted on the advertisement website 200 by the advertisement provider 30 located at the same area as the specific area among the advertisements registered in the advertisement website 200, the advertisement to be promoted in the specific area, and an advertisement which advertises a product to be sold in the specific area.", "The operator server 100 provides the searched advertisements to the user terminal for the designated time such that the searched advertisements are displayed on the screen of the user terminal 20 for a time designated for each advertisement (for example, a specific time zone) (S150).", "That is, all members of the advertisement website 200 include an advertisement provider 30 that posts the advertisement, and an advertisement viewer 40 who watches the advertisement, and the members who post or watch the advertisement may be advertisement providers 30 and advertisement viewers 40 at the same time.", "At this time, when the advertisements are posted on the advertisement website 200, the advertisement provider 30 may set the advertisements such that the advertisements can be seen by the advertisement viewers for the designated time for each advertisement (for example, a specific time zone).", "Hereinafter, the present invention will be described in more detail with reference to FIGS.", "3 to 9.FIGS.", "3 to 9 illustrate the advertisement website 200 including the local selection menu 300, the advertisement display region 400, and the bulletin board region 500 according to the present invention.", "As an example, as illustrated in FIG.", "3, if the user terminal 20 located in Korean is accessed to the first advertisement webpage 200, within the advertisement website displayed on the screen of the user terminal 20, the local selection menu 300 includes the area items indicating the above-mentioned Korean area, Korean upper area items (Asia), and a plurality of lower area items in Korea.", "Also, in the advertisement display region 400, the advertisements in which at least one of the number of viewing times of and preference is greater than or equal to the reference value for subscribers of the advertisement website among advertisements posted in the Korean area are preferentially displayed.", "Here, the preference indicates the reaction by the subscriber obtained by buttons such as “good” and “empathy” displayed on the advertisement, and is determined on the basis of the cumulative number of times for pushing the button.", "On the other hand, a hashtag may also be used to preferentially display advertisements to be interested by the subscribers in the advertisement display region 400.The hashtag means a type of metadata which is formed to facilitate classification and search of the posts.", "In the on-line advertisement method according to an embodiment of the present invention, when an advertiser posts the advertisement, it is possible to input a keyword representing the contents of the advertisement by the hashtag.", "At this time, a plurality of hashtags may be added in accordance with the attributes of the advertisement.", "Furthermore, it is also possible to allow a subscriber to input keywords to be interested in advance.", "Through the aforementioned process, the hashtag added to the advertisement is compared with the keyword input by the subscriber, and the advertisement to which the hashtag identical or similar to the keyword input by the subscriber is added may be preferentially displayed.", "For example, if an arbitrary advertiser adds hashtags “a” and “b” to his/her advertisement, the advertisement may be preferentially exposed to the subscriber who inputs “a” or “b” as the keyword interested among the plurality of subscribers.", "According to an embodiment of the present invention, when the user displays an advertisement to which the same hashtag as the keyword registered in advance is added, as illustrated in FIG.", "3, the advertisement may be displayed in the form in which the background color or the frame of the advertisement is colored in an arbitrary color.", "In other words, advertisements to be interested by the users can be displayed to be seen more clearly in the eyes.", "Therefore, it is possible to achieve the effect that the advertisement effect can be maximized in consideration of the preference of the subscriber.", "At this time, as illustrated in FIGS.", "3 to 5, the number of advertisements displayed in the advertisement display region 400 is set such that the number of the areas selected through the local selection menu 300 decreases as ascending to the upper area, the number of selected areas increases as descending to the lower area, and the number of the advertisements of each area may be limited.", "As an example, three advertisements are displayed in the advertisement display region 400 in the Korean area of FIG.", "3, but as illustrated in FIG.", "4, when Seongnam area item is selected in the local selection menu 300 and the area zone descends to the lower area from Korean area to Seongnam area, advertisements related to the selected Seongnam area are searched and displayed in the advertisement display region 400, but five advertisements greater than the Korean area are displayed.", "Further, as illustrated in FIG.", "5, when a Bundang area item is selected in the local selection menu 300, and the area zone descends to the lower area from Seongnam area to Bundang area, the advertisements related to the selected Bundang area is searched and displayed in the advertisement display region 400, but eight advertisements greater than the Seongnam area are displayed.", "Of course, unlike FIGS.", "3 through 5, the setting can also be provided such that as the number of advertisements increases as ascending to the upper area, the number of advertisements decreases as descending to the lower area, and it is also possible to set the same number of advertisements of the upper area and the lower area.", "According to an embodiment of the present invention, it is possible to utilize the population living in each area in order to determine the number of advertisements displayed in the advertisement display region 400 of the upper area and the lower area.", "To this end, the on-line advertisement providing method according to the embodiment of the present invention can be provided so that the number of advertisements corresponding to the population is displayed, using the regional population database.", "For example, the number may be determined such that eight advertisements are displayed in the advertisement display region 400 of an area with a population of 500,000 or less, and five advertisements are displayed in the advertisement display region 400 of an area of exceeding 500,000 and less than one million.", "As described above, if the number of advertisements displayed in the advertisement display region 400 is automatically determined by utilizing the population living in each group, it is possible to automatically determine the number of advertisements without inconvenience in which the administrator needs to determine the number of advertisements displayed in the advertisement display region 400 for each area one by one.", "Furthermore, the posting retention time of the advertisements displayed in the advertisement display region 400 may be gradually shorter as the area selected through the local selection menu 200 descends to the lower area.", "As an example, in the Korean area of FIG.", "3, advertisements related to the Korean area are posted for two hours and then exchanged with other advertisements.", "However, as illustrated in FIG.", "4, if the Korean area descends to the lower area toward Seongnam area, the advertisements related to Seongnam may be posted for one hour shorter than the advertisements related to Korean area.", "Further, the advertisements displayed in the advertisement display region 400 may be gradually moved toward the upper area than the posted area and posted in that area, when the number of viewing times or preference becomes higher than the reference value by the subscribers in the advertisement website 200.As an example, when the number of viewing times or preference of a specific advertisement becomes higher than the first reference value among the advertisements related to Bundang area in FIG.", "5, the specific advertisement is moved to the advertisement related to Seongnam area and posted in the area.", "When the number of viewing times or the preference of the specific advertisement moved to the advertisement related to the Seongnam area becomes higher than the second reference value (the second reference value>the first reference value), the specific advertisement may be moved to advertisement related to Gyeonggi area and posted in the area.", "Further, the advertisement contents of the advertisements displayed in the advertisement display region 400 may gradually summarized and displayed, as the area selected through the local selection menu 200 descends to the lower area.", "As an example, in the South Korean area in FIG.", "3, advertisements related to the Korean area are displayed including images, text etc related to the public relations.", "However, as illustrated in FIG.", "4, when the Korean area descends to the lower area toward the Seongnam area, some advertisement contents of the advertisements related to Seongnam are gradually displayed in smaller sizes than the advertisements related to the above-mentioned Korean area.", "As illustrated in FIG.", "5, when the above-mentioned Seongnam area descends to the lower area toward the Bundang area, some texts of the advertisements related to Bundang are summarized and displayed to a gradually smaller size than the above-mentioned advertisements related to Seongnam area.", "On the other hand, the advertisements displayed in the advertisement display region 400 in FIGS.", "3 to 5 are advertisements capable of paying the points displayed when the first bulletin board 510 is selected and activated in the bulletin board region 500.That is, when the first bulletin board 510 is selected and activated in the bulletin board region 500, the advertisements capable of paying points are searched and displayed in the advertisement display region 400.That is to say, the first bulletin board 510 is a bulletin board on which the advertisements that pay the points to the user terminal 20 when the user terminal 20 selects (or watches) an advertisement of another subscriber displayed in the advertisement display region 400.Further, the user terminal 20 can post a free advertisement in the first bulletin board 510, using the paid point in the first bulletin board 510.At this time, the user (one of the advertisement provider and the advertisement viewer) of the user terminal 20 can purchase the area for posting the advertisement on the advertisement display region 40 in the first bulletin board 510, the posting time, and the position in the advertisement display region 400, using the points paid to the user terminal 20, by auction.", "Also, the points paid by the advertisement related to the upper area may be larger than the points paid by the advertisement related to the lower area among the advertisements displayed on the first bulletin board 510.As an example, the points paid by advertisements posted in the Seongnam area may be greater than the points paid by the advertisements posted in the Bundang area.", "In addition, although the user of the user terminal 20 tries to post the desired advertisements, if the saved points of the user are insufficient, the user may purchase the points by cash via the advertisement website 200 or may receive the points of other users, thereby purchasing the area for posting the advertisement, the posting time, and the position in the advertisement display region 400 by auction.", "In other words, the first bulletin board 510 is an SNS platform having a global advertisement (or questionnaire) function in the form of a website and an application and a commercial transaction function.", "The first bulletin board 510 is a platform which provides the function of a bulletin board that allows the users (advertisement providers or advertisement viewers) to post advertisements or questionnaires for free or with fee for a guaranteed period of time in a desired area and at a desired time zone anywhere in the world, and provides market functions for allowing customers of the desired areas to sell products and purchase products of the desired areas.", "Next, the second bulletin board 520 selected and activated in the bulletin board region 500 in FIG.", "6 is a “Power Board” which is a bulletin board that displays advertisements capable of saving cash at the time of selecting or viewing the advertisements in the advertisement display region 400.In other words, the second bulletin board 520 is a bulletin board which receives the accumulation of cash provided by the advertisement provider 30 when the user terminal 20 completes the mission (at least one act of advertisement viewing, participation in survey, and installation of the application) posted by the advertisement provider 30.At this time, the user terminal 20 may receive the saved cash from a fifth bulletin board 550 as a market board to be described later, purchase the product advertised on the fifth bulletin board 550 with the saved cash, or exchange the cash for points of other cyber money.", "Next, the third bulletin board 530 selected and activated in the bulletin board region 500 in FIG.", "7 is a “My Board” which is a bulletin board for managing personal information of the user terminal 20, advertisement/questionnaire posted by the user terminal 20, advertisement/questionnaire of other subscribers scrapped by the user terminal 20, cash/points saved by the user terminal 20, and the like.", "As an example, FIG.", "7 illustrates a configuration in which the user's personal information of the user terminal 20, the number of advertisements scrapped by the user terminal 20 in the advertisement website 200, the number of questionnaires scrapped by the user terminal 20 in the advertisement website 200, the cash and points etc.", "saved by the user terminal 20 are displayed in the third bulletin board 530.As another example, an advertisement with a hashtag identical or similar to the keyword input by the user may be displayed on the third bulletin board 530.In other words, since the advertisements to be interested by users are automatically collected and provided, the advertisement effect can be maximized.", "When the advertisements to which the hashtag identical or similar to the keyword registered by user in advance are displayed on the third bulletin board 530, an optional identifier may be added to the advertisements.", "Here, the identifier is used for displaying the advertisement corresponding to the keyword registered by the user in advance, and may be added to a partial region of the advertisement.", "Or, the identifier may be added in the manner of displaying the background color of the advertisement or the color of the frame line to be different from the general advertisement.", "At this time, the identifier may be displayed in a darker color as the similarity between the hashtag added to the advertisement and the keyword registered by the user in advance is higher, or may be added in such a manner that the size of the identifier increases.", "Next, the fourth bulletin board 540 selected and activated in the bulletin board region 500 in FIG.", "8 is a “Friends Board”.", "In the fourth bulletin board 540, information (including at least one of personal information and greetings of other subscribers) of other subscribers registered by the user terminal friend 20 as friends is displayed.", "The advertisement registered by the friends on the advertisement website 200 may be arranged and displayed in a recent time zone.", "When specific other subscriber information is selected by the user terminal 20, the bulletin board moves to the above “My Board” of the friend and the advertisement posted by the friend can be watched.", "Similarly to the third bulletin board 530, the fourth bulletin board 540 may display advertisements with the added hashtag matching the keywords registered by the user in advance.", "For example, it is possible to display an advertisement to which a hashtag matching the keyword registered by another subscriber registered as a friend is added.", "Therefore, it is possible to check advertisements to be interested by another subscriber registered as a friend.", "At this time, the advertisement displayed on the fourth bulletin board 540 may also be provided to the user in the state in which an arbitrary identifier is added as displayed on the third bulletin board 530.On the other hand, the on-line advertisement providing method according to an embodiment of the present invention can also provide a function of sending a message to another subscriber registered as a friend as illustrated in FIG.", "8.According to an embodiment of the present invention, when sending a message to another subscriber registered as a friend, an advertisement to be interested by another subscriber may be displayed in a partial region to be sent.", "For example, when sending a message to a friend A, it is possible to send an advertisement with the added hashtag matching the keyword registered by the friend A in advance together with the message.", "At this time, the advertisement may be sent so as to be included in a partial region of the message.", "Therefore, even if the user is not accessed to the local advertisement bulletin board, it is possible to achieve the effect capable of automatically providing advertisements to be interested by the user.", "Finally, the fifth bulletin board 550 selected and activated in the bulletin board region 500 in FIG.", "9 is a “Market Board”.", "The advertisements of the products that can be purchased at the cash/point saved via the advertisement website 200 are displayed on the fifth bulletin board, and the user terminal 20 can purchase the products at the cash/point saved by the user.", "In addition, the user terminal 20 may apply for payment of the saved cash in the fifth bulletin board 550 or exchange the saved cash for points of other cyber money.", "Although the present invention has been illustrated and described in relation to a specific embodiment, a person having ordinary knowledge in the industry will be able to easily know that various modifications and changes can be made within the scope that does not depart from the spirit and scope of the invention indicated by the appended claims." ] ]
Patent_15874339
[ [ "METHOD OF MAKING LED LIGHT BULB WITH THERMAL RADIATION FILAMENTS", "A method of making a LED light bulb with thermal radiation filaments contains steps of: A. providing a substrate which includes multiple conductive portions formed on two ends of the substrate respectively so as to electrically connect with an electronic circuit; B. molding LED chips, wires, and phosphors on a front face of the substrate so as to produce a LED filament sheet; C. forming a thermal radiation dissipation film on a back face of the substrate before or after producing the LED filament sheet; D. cutting the substrate into the thermal radiation filaments, wherein each of the thermal radiation filaments has a part of the thermal radiation dissipation film, a part of the LED filament sheet, and parts of the multiple conductive portions respectively; and E. fixing the thermal radiation filaments into the LED light bulb." ], [ "1.A method of making a LED light bulb with thermal radiation filaments comprising steps of: A. providing a substrate which includes multiple conductive portions formed on two ends of the substrate respectively so as to electrically connect with an electronic circuit; B. molding LED chips, wires, and phosphors on a front face of the substrate so as to produce a LED filament sheet; C. forming a thermal radiation dissipation film on a back face of the substrate before or after producing the LED filament sheet; D. cutting the substrate into the thermal radiation filaments, wherein each of the thermal radiation filaments has a part of the thermal radiation dissipation film, a part of the LED filament sheet, and parts of the multiple conductive portions respectively; and E. fixing the thermal radiation filaments into the LED light bulb.", "2.The method as claimed in claim 1, wherein in the step B has sub-steps of: B1.die bonding, wherein the LED chips are die bonded to the front face of the substrate; B2.wire bonding, wherein the wires are serially connected with the LED chips and are electrically connected with the multiple conductive portions of the substrate respectively so as to form a serial circuit; and B3.forming the phosphors, wherein phosphor glue is coated on the LED chips so as to form the phosphors on the LED chips.", "3.The method as claimed in claim 1, wherein phosphor glue is coated on the LED chips and the wires so that the phosphors cover the LED chips and the wires, and the phosphors do not cover the multiple conductive portions of the substrate.", "4.The method as claimed in claim 1, wherein the thermal radiation dissipation film is formed on the back face of the substrate by coating thermal radiation dissipation ink on the back face of the substrate.", "5.The method as claimed in claim 1, wherein the thermal radiation dissipation film is formed on the back face of the substrate by adhering the thermal radiation dissipation film on the back face of the substrate, and the thermal radiation dissipation film has an adhesive layer.", "6.The method as claimed in claim 5, wherein the adhesive layer is thermally conductive adhesive or thermal tape.", "7.The method as claimed in claim 1, wherein the substrate is made any one of metal, ceramic, glass, and plastic.", "8.The method as claimed in claim 1, wherein the substrate is made any one of metal, flexible ceramic, flexible glass, and plastic.", "9.The method as claimed in claim 1, wherein the thermal radiation filaments are fixed into the LED light bulb and are bent at a curvature or in an arc shape.", "10.The method as claimed in claim 8, wherein the thermal radiation filaments are fixed into the LED light bulb and are bent at a curvature or in an arc shape.", "11.The method as claimed in claim 1, wherein the thermal radiation dissipation film is formed on the back face of the substrate by coating thermal radiation dissipation ink on the back face of the substrate in any one of a spray coating manner, a brushing manner, a screen printing manner, and a nozzle printing manner, 12.The method as claimed in claim 1, wherein the thermal radiation dissipation ink contains dissipation fillers, dispersants, and binders.", "13.The method as claimed in claim 12, wherein the dissipation fillers are any one of carbon materials, metal particles, infrared-ray radiation powders, and a mixture of the carbon materials, the metal particles, and the infrared-ray radiation powders.", "14.The method as claimed in claim 12, wherein the carbon materials are any one of graphene, carbon black, graphite, carbon nanotubes, activated carbon and a mixture of the graphene, the carbon black, the graphite, the carbon nanotubes, and the activated carbon.", "15.The method as claimed in claim 12, wherein the metal particles are any one of copper (Cu), nickel (Ni), zinc (Zn), iron (Fe), cobalt (Co), silver (Ag), gold (Au), platinum (Pt), and a mixture of the Cu, the Ni, the Zn, the Fe, the Co, the Ag, the Au, and the Pt.", "16.The method as claimed in claim 12, wherein the infrared-ray radiation powders are made of any one of silica (SiO2), alumina (Al2O3), titanium dioxide (TiO2), zirconia (ZrO2), zirconium carbide (ZrC), silicon Carbide (SiC), tantalum carbide (TaC), titanium diboride (TiB2), zirconium diboride (ZrB2), two titanium silicide (TiSi2), silicon nitride (Si3N4), titanium nitride (TiN), boron nitride (BN), and a mixture of the SiO2, the Al2O3, the TiO2, the ZrO2, the ZrC, the SiC, the TaC, the TiB2, the ZrB2, the TiSi2, the Si3N4, the TiN, and the BN." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>This application is a Continuation-in-Part of application Ser.", "No.", "14/721,021, filed on May 26, 2015.cross-reference-to-related-applications description=\"Cross Reference To Related Applications\" end=\"tail\"?" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The primary aspect of the present invention is to provide a method of making a LED light bulb with thermal radiation filaments which removes heat away from a heat source rapidly.", "To obtain the above aspect, a method of making a LED light bulb with thermal radiation filaments provided by the present invention contains steps of: A. providing a substrate which includes multiple conductive portions formed on two ends of the substrate respectively so as to electrically connect with an electronic circuit; B. molding LED chips, wires, and phosphors on a front face of the substrate so as to produce a LED filament sheet; C. forming a thermal radiation dissipation film on a back face of the substrate before or after producing the LED filament sheet; D. cutting the substrate into the thermal radiation filaments, wherein each of the thermal radiation filaments has a part of the thermal radiation dissipation film, a part of the LED filament sheet, and parts of the multiple conductive portions respectively; and E. fixing the thermal radiation filaments into the LED light bulb.", "Preferably, in the step B has sub-steps of: B 1 .", "die bonding, wherein the LED chips are die bonded to the front face of the substrate; B 2 .", "wire bonding, wherein the wires are serially connected with the LED chips and are electrically connected with the multiple conductive portions of the substrate respectively so as to form a serial circuit; and B 3 .", "forming the phosphors, wherein a phosphor glue is coated on the LED chips so as to form the phosphors on the LED chips.", "Preferably, phosphor glue is coated on the LED chips and the wires so that the phosphors cover the LED chips and the wires, and the phosphors do not cover the multiple conductive portions of the substrate.", "Preferably, the thermal radiation dissipation film is formed on the back face of the substrate by coating thermal radiation dissipation ink on the back face of the substrate.", "Preferably, the thermal radiation dissipation film is formed on the back face of the substrate by adhering the thermal radiation dissipation film on the back face of the substrate, and the thermal radiation dissipation film has an adhesive layer.", "Preferably, the adhesive layer is thermally conductive adhesive or thermal tape.", "Preferably, the substrate is made any one of metal, ceramic, glass, and plastic.", "Preferably, the substrate is made any one of metal, flexible ceramic, flexible glass, and plastic.", "Preferably, the thermal radiation filaments are fixed into the LED light bulb and are bent at a curvature or in an arc shape.", "Preferably, the thermal radiation dissipation film is formed on the back face of the substrate by coating thermal radiation dissipation ink on the back face of the substrate in any one of a spray coating manner, a brushing manner, a screen printing manner, and a nozzle printing manner, Preferably, the thermal radiation dissipation ink contains dissipation fillers, dispersants, and binders.", "Preferably, the dissipation fillers are any one of carbon materials, metal particles, infrared-ray radiation powders, and a mixture of the carbon materials, the metal particles, and the infrared-ray radiation powders.", "Preferably, the carbon materials are any one of graphene, carbon black, graphite, carbon nanotubes, activated carbon and a mixture of the graphene, the carbon black, the graphite, the carbon nanotubes, and the activated carbon.", "Preferably, the metal particles are any one of copper (Cu), nickel (Ni), zinc (Zn), iron (Fe), cobalt (Co), silver (Ag), gold (Au), platinum (Pt), and a mixture of the Cu, the Ni, the Zn, the Fe, the Co, the Ag, the Au, and the Pt.", "Preferably, the infrared-ray radiation powders are made of any one of silica (SiO2), alumina (Al2O3), titanium dioxide (TiO2), zirconia (ZrO2), zirconium carbide (ZrC), silicon Carbide (SiC), tantalum carbide (TaC), titanium diboride (TiB2), zirconium diboride (ZrB2), two titanium silicide (TiSi2), silicon nitride (Si3N4), titanium nitride (TiN), boron nitride (BN), and a mixture of the SiO2, the Al2O3, the TiO2, the ZrO2, the ZrC, the SiC, the TaC, the TiB2, the ZrB2, the TiSi2, the Si3N4, the TiN, and the BN." ], [ "BACKGROUND OF THE INVENTION This application is a Continuation-in-Part of application Ser.", "No.", "14/721,021, filed on May 26, 2015.FIELD OF THE INVENTION The present invention relates to a method of making LED light bulb, and more particularly to a method of making a LED light bulb with thermal radiation filaments.", "DESCRIPTION OF THE PRIOR ART A conventional light bulb is disclosed in U.S.", "Publication No.", "20140211475 and contain: a light-emitting module; a heat-dissipation carrier including a first surface and a second surface opposite to the first surface, disposed under the light-emitting module for conducting heat generated by the light-emitting module away from the light-emitting module; and a heat radiator disposed above the heat-dissipation carrier for radiating heat away from the heat-dissipation carrier, wherein the material of the heat-radiating material coated on the surface of the heat radiator can include carbon-containing compound such as SiC, graphene, metal oxide such as ZnO, or III-nitride compound such as BN.", "However, as high-power LED bulb is required to generate enough light for illumination purpose rather than direction light, the heat-dissipation design became insufficient so that the heat-dissipation carrier is often enlarged to be bulky metal heat skin, and more effective heat spreading materials are required.", "The developed thermal management of LED bulb increases the cost of bulbs and the cooling structure is both bulky and heavy that offsets the benefits of LED.", "For light bulb application, thermal conductivity only allows heat to be conducted downward to the base.", "Honestly speaking, this is not efficient because filament will be connected to electronics which generate more heat.", "Furthermore, the power electronics will be kept in the very tight enclosure like E27/GU10 connector.", "The heat dissipation is problematic.", "Graphene has been well-known for its outstanding heat conductivity, and high surface area.", "Both properties indicate graphene to be a promising candidate of heat-spreading solution.", "However, relative designs in recent years show several shortages.", "US Publication No.", "20100085713 proposed lateral graphene as heat spreaders for electronic device and circuits.", "The integration process, either growing graphene by CVD process or transferring exfoliated graphene, is high cost and fairly complicated, which is not favorable for commercialization.", "Graphene film/papers are proposed as heat spreaders such as US Publication No.", "20130329366 and US Publication No.", "20140224466.Graphene films were produced from graphene nanoplatelets.", "By compression, graphene films were formed.", "However, the adhesion of films onto heat source or heat sink may create another heat resistance between interfaces, and lower the heat dissipation effect.", "The present invention has arisen to mitigate and/or obviate the afore-described disadvantages.", "SUMMARY OF THE INVENTION The primary aspect of the present invention is to provide a method of making a LED light bulb with thermal radiation filaments which removes heat away from a heat source rapidly.", "To obtain the above aspect, a method of making a LED light bulb with thermal radiation filaments provided by the present invention contains steps of: A. providing a substrate which includes multiple conductive portions formed on two ends of the substrate respectively so as to electrically connect with an electronic circuit; B. molding LED chips, wires, and phosphors on a front face of the substrate so as to produce a LED filament sheet; C. forming a thermal radiation dissipation film on a back face of the substrate before or after producing the LED filament sheet; D. cutting the substrate into the thermal radiation filaments, wherein each of the thermal radiation filaments has a part of the thermal radiation dissipation film, a part of the LED filament sheet, and parts of the multiple conductive portions respectively; and E. fixing the thermal radiation filaments into the LED light bulb.", "Preferably, in the step B has sub-steps of: B1.die bonding, wherein the LED chips are die bonded to the front face of the substrate; B2.wire bonding, wherein the wires are serially connected with the LED chips and are electrically connected with the multiple conductive portions of the substrate respectively so as to form a serial circuit; and B3.forming the phosphors, wherein a phosphor glue is coated on the LED chips so as to form the phosphors on the LED chips.", "Preferably, phosphor glue is coated on the LED chips and the wires so that the phosphors cover the LED chips and the wires, and the phosphors do not cover the multiple conductive portions of the substrate.", "Preferably, the thermal radiation dissipation film is formed on the back face of the substrate by coating thermal radiation dissipation ink on the back face of the substrate.", "Preferably, the thermal radiation dissipation film is formed on the back face of the substrate by adhering the thermal radiation dissipation film on the back face of the substrate, and the thermal radiation dissipation film has an adhesive layer.", "Preferably, the adhesive layer is thermally conductive adhesive or thermal tape.", "Preferably, the substrate is made any one of metal, ceramic, glass, and plastic.", "Preferably, the substrate is made any one of metal, flexible ceramic, flexible glass, and plastic.", "Preferably, the thermal radiation filaments are fixed into the LED light bulb and are bent at a curvature or in an arc shape.", "Preferably, the thermal radiation dissipation film is formed on the back face of the substrate by coating thermal radiation dissipation ink on the back face of the substrate in any one of a spray coating manner, a brushing manner, a screen printing manner, and a nozzle printing manner, Preferably, the thermal radiation dissipation ink contains dissipation fillers, dispersants, and binders.", "Preferably, the dissipation fillers are any one of carbon materials, metal particles, infrared-ray radiation powders, and a mixture of the carbon materials, the metal particles, and the infrared-ray radiation powders.", "Preferably, the carbon materials are any one of graphene, carbon black, graphite, carbon nanotubes, activated carbon and a mixture of the graphene, the carbon black, the graphite, the carbon nanotubes, and the activated carbon.", "Preferably, the metal particles are any one of copper (Cu), nickel (Ni), zinc (Zn), iron (Fe), cobalt (Co), silver (Ag), gold (Au), platinum (Pt), and a mixture of the Cu, the Ni, the Zn, the Fe, the Co, the Ag, the Au, and the Pt.", "Preferably, the infrared-ray radiation powders are made of any one of silica (SiO2), alumina (Al2O3), titanium dioxide (TiO2), zirconia (ZrO2), zirconium carbide (ZrC), silicon Carbide (SiC), tantalum carbide (TaC), titanium diboride (TiB2), zirconium diboride (ZrB2), two titanium silicide (TiSi2), silicon nitride (Si3N4), titanium nitride (TiN), boron nitride (BN), and a mixture of the SiO2, the Al2O3, the TiO2, the ZrO2, the ZrC, the SiC, the TaC, the TiB2, the ZrB2, the TiSi2, the Si3N4, the TiN, and the BN.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 shows a thermal radiation dissipation film being coated on a polyethylene terephthalate (PET) substrate, and the measurement tool of thermal conductivity.", "FIG.", "2 shows a thermal conductivity of the thermal radiation dissipation film, which is in a range from 40 W/mK to 90 W/mK at room temperature.", "FIG.", "3 is a flow chart showing a method of making a LED light bulb with thermal radiation filaments according to a preferred embodiment of the present invention.", "FIG.", "4 is a flow chart showing sub-steps of a step of B of the method of the LED bulb with the thermal radiation filaments according to the preferred embodiment of the present invention.", "FIG.", "5 is a flow chart showing a method of making a LED light bulb with thermal radiation filaments according to another preferred embodiment of the present invention.", "FIG.", "6-1 shows a substrate, which is printed circuit board (PCB) in the front side according to the preferred embodiment of the present invention.", "FIG.", "6-2 shows a substrate, which is printed circuit board (PCB) in the back side according to the preferred embodiment of the present invention.", "FIGS.", "7 to 12 are schematic views showing steps of making the LED light bulb of FIG.", "3 according to the preferred embodiment of the present invention.", "FIG.", "13 is a cross sectional view showing the assembly of a thermal radiation filament according to the preferred embodiment of the present invention.", "FIG.", "14 is another cross sectional view showing the assembly of the thermal radiation filament according to the preferred embodiment of the present invention.", "FIG.", "15-1 is a schematic view showing a graphene-based thermal radiation dissipation film being coated on a substrate made of copper according to the preferred embodiment of the present invention.", "FIG.", "15-2 is a schematic view showing a graphene-based thermal radiation dissipation film being coated on a substrate made of aluminum according to the preferred embodiment of the present invention.", "FIG.", "15-3 is a schematic view showing a graphene-based thermal radiation dissipation film being coated on substrate made of PET according to the preferred embodiment of the present invention.", "FIG.", "16 is a schematic view showing the assembly of a thermal radiation filament according to another preferred embodiment of the present invention.", "FIG.", "17 is a schematic view showing temperatures of the thermal radiation filaments of the present invention reduce 25° C. less than conventional LED filaments after a period of using time.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS With reference to FIGS.", "1 to 2, a graphene laminate film is deposited on a polyethylene terephthalate (PET) substrate, and a thermal conductivity of the graphene laminate film is within 40 W/mK to 90 W/mK at a room temperature so as to provide up to 600× higher thermal conductivity than plastics.", "Thus, a LED light bulb with thermal radiation filaments made by a method of a preferred embodiment of the present invention removes heat away from a heat source rapidly.", "Referring to FIGS.", "3, 6-1, 6-2, 7 and 12, a method of making the LED light bulb with the thermal radiation filaments according to the preferred embodiment of the present invention comprising the steps of: A. providing a substrate 10 which includes multiple conductive portions 12 formed on two ends of the substrate 10 respectively so as to electrically connect with an electronic circuit (as shown in FIG.", "6-1), wherein the substrate 10 is made any one of metal, ceramic, glass, and plastic; B. molding LED chips 21, wires 23, and phosphors 22 on a front face of the substrate 10 so as to produce a LED filament sheet 20 (as shown in FIG.", "7 and FIG.", "8); C. forming the thermal radiation dissipation film 30 on a back face 11 of the substrate 10 (as illustrated in FIG.", "9) before or after producing the LED filament sheet 20; D. cutting the substrate 10 (as shown in FIG.", "10) into the thermal radiation filaments 40 (as illustrated in FIG.", "11), wherein each of the thermal radiation filaments 40 has a part of the thermal radiation dissipation film 30 on a part of the back face 11, a part of the LED filament sheet 20 on a part of the front face of the substrate 10, and parts of the multiple conductive portions 12 on parts of the two ends of the substrate 10 respectively; and E. fixing the thermal radiation filaments 40 into the LED light bulb 50 (as shown in FIG.", "12).", "Referring to FIG.", "16, in another preferred embodiment, the LED filament sheet 20 includes multiple bases 24 connected together, wherein each of the multiple bases 24 has a LED chip 21, a wire 23, and phosphors 22 on a front face of each base 24, and the base 24 is cut into thermal radiation filaments 40.With reference to FIG.", "4, the step B has sub-steps of: B1.die bonding, wherein the LED chips 21 are die bonded to the front face of the substrate 10; B2.wire bonding, wherein the wires 23 are serially connected with the LED chips 21 and are electrically connected with the multiple conductive portions 12 of the substrate 10 respectively so as to form a serial circuit; and B3.forming the phosphors 22, wherein phosphor glue is coated on the LED chips 21 so as to form the phosphors 22 on the LED chips 21.In another embodiment, the phosphor glue is coated on the LED chips 21 and the wires 23 so that the phosphors 22 cover the LED chips 21 and the wires 23, as illustrated in FIG.", "13, and the phosphors 22 do not cover the multiple conductive portions 12 of the substrate 10.With reference to FIG.", "5, a method of making a LED light bulb with thermal radiation filaments according to another preferred embodiment of the present invention comprising the steps of: A. providing a substrate 10 which includes multiple conductive portions 12 formed on two ends of the substrate 10 respectively so as to electrically connect with an electronic circuit, wherein the substrate 10 is made any one of metal, ceramic, glass, and plastic; B. molding LED chips 21, wires 23, and phosphors 22 on a front face of the substrate 10 so as to produce a LED filament sheet 20 (as shown in FIG.", "7 and FIG.", "8); C. forming the thermal radiation dissipation film 30 on a back face 11 of the substrate 10 (as illustrated in FIG.", "9) before or after producing the LED filament sheet 20; D. cutting the substrate 10 (as shown in FIG.", "10) into the thermal radiation filaments 40 (as illustrated in FIG.", "11), wherein each of the thermal radiation filaments 40 has a part of the thermal radiation dissipation film 30 on a part of the back face 11, a part of the LED filament sheet 20 on a part of the front face of the substrate 10, and parts of the multiple conductive portions 12 on parts of two ends of the substrate 10 respectively; and E′.", "fixing the thermal radiation filaments 40 into the LED light bulb 50 and bending the thermal radiation filaments 40 at a curvature or in an arc shape.", "Preferably, the substrate 10 is made any one of metal, flexible ceramic, flexible glass, and plastic.", "Thereby, the thermal radiation filaments 40 are curvedly fixed into the LED light bulb 50 based on a shape of the LED light bulb 50.The thermal radiation dissipation film 30 is formed on the back face 11 of the substrate 10 by coating thermal radiation dissipation ink 14 on the back face 11 of the substrate 10 in any one of a spray coating manner, a brushing manner, a screen printing manner, and a nozzle printing manner, and the thermal radiation dissipation ink 14 is dried so as to form the thermal radiation dissipation film 30.In another embodiment, the thermal radiation dissipation film 30 is formed on the back face 11 of the substrate 10 by adhering the thermal radiation dissipation film 30 on the back face 11 of the substrate 10, wherein the thermal radiation dissipation film 30 has an adhesive layer 13, as shown in FIG.", "14, and the adhesive layer 13 is thermally conductive adhesive or thermal tape.", "The thermal radiation dissipation ink 14 contains dissipation fillers, dispersants, and binders, wherein the dissipation fillers are any one of carbon materials, metal particles, infrared-ray radiation powders, and a mixture of the carbon materials, the metal particles, and the infrared-ray radiation powders.", "The carbon materials are any one of graphene, carbon black, graphite, carbon nanotubes, activated carbon and a mixture of the graphene, the carbon black, the graphite, the carbon nanotubes, and the activated carbon.", "The metal particles are any one of copper (Cu), nickel (Ni), zinc (Zn), iron (Fe), cobalt (Co), silver (Ag), gold (Au), platinum (Pt), and a mixture of the Cu, the Ni, the Zn, the Fe, the Co, the Ag, the Au, and the Pt.", "The infrared-ray radiation powders are made of any one of silica (SiO2), alumina (Al2O3), titanium dioxide (TiO2), zirconia (ZrO2), zirconium carbide (ZrC), silicon Carbide (SiC), tantalum carbide (TaC), titanium diboride (TiB2), zirconium diboride (ZrB2), two titanium silicide (TiSi2), silicon nitride (Si3N4), titanium nitride (TiN), boron nitride (BN), and a mixture of the SiO2, the Al2O3, the TiO2, the ZrO2, the ZrC, the SiC, the TaC, the TiB2, the ZrB2, the TiSi2, the Si3N4, the TiN, and the BN.", "The carbon materials are made of graphene so that the thermal radiation dissipation ink 14 forms a graphene-based thermal radiation dissipation film, thus obtaining brilliant heat dissipation.", "For example, the graphene-based thermal radiation dissipation film is coated on substrates (as shown in FIGS.", "15-1 to 15-3) and temperatures of the substrates 10 are measured respectively, wherein the substrates 10 are made of copper as shown in FIG.", "15-1; the substrates 10 are made of aluminum as illustrated in FIG.", "15-2; and the substrates 10 are made of PET as shown in FIG.", "15-3.With reference to FIG.", "17, temperatures of the thermal radiation filaments 40 of the present invention reduce 25° C. less than conventional LED filaments after a period of using time.", "Preferably, the thermal radiation filaments 40 prolong a service life of the LED light bulb 50 effectively.", "While the preferred embodiments of the invention have been set forth for the purpose of disclosure, modifications of the disclosed embodiments of the invention as well as other embodiments thereof may occur to skilled in the art.", "Accordingly, the appended claims are intended to cover all embodiments which do not depart from the spirit and scope of the invention." ] ]
Patent_15874343
[ [ "IMAGE PROCESSOR", "A setting circuit sets a quantization value per input image on the basis of a noise value of the whole input image, and a quantization circuit performs quantization on first image data to generate second image data.", "Quantization value based on the noise value the whole input image can realize appropriate denoising depending on the noise level of the whole input image." ], [ "1.An image processor configured to perform denoising on an input image to output an output image, the image processor comprising: a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components; a quantization circuit configured to perform quantization on the second image data to generate third image data; a correction circuit configured to perform correction per frequency component on the third image data to generate fourth image data; and a first correction value setting circuit configured to set a first correction value per input image for correction based on the second image data of the whole input image, the first correction value setting circuit being configured to set the first correction value to a transform value for transforming each frequency component value in the input image such that a ratio among frequency component values in the input image equals to that in an ideal image including no noise.", "2.The image processor according to claim 1, further comprising: an arithmetic circuit configured to calculate a per-block activity evaluation value based on the first image data; and a second correction value setting circuit configured to set a per-block second correction value for correction based on the first correction value and the per-block activity evaluation value.", "3.The image processor according to claim 2, wherein the second correction value setting circuit is configured to hold a plurality of different masks depending on activity evaluation values, the masks containing arbitrary multipliers by frequency components, and perform masking on the first correction value using one of the masks corresponding to the activity evaluation value calculated by the arithmetic circuit to set the second correction value.", "4.The image processor according to claim 3, wherein the second correction value setting circuit is configured to set the second correction value for a block having a small activity evaluation value to the first correction value for a low-frequency component, while setting the second correction value to substantially zero for middle- and high-frequency components; the second correction value for a block having a medium activity evaluation value to the first correction value for low- and middle-frequency components, while setting the second correction value to substantially zero for a high-frequency component; and the second correction value for a block having a large activity evaluation value to the first correction value for low-, middle-, and high-frequency components.", "5.The image processor according to claim 2, further comprising: a smoothing circuit configured to calculate a smoothing value of each pixel based on a pixel value of each pixel and a pixel value of a plurality of adjacent pixels, the arithmetic circuit being configured to calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "6.The image processor according to claim 1, further comprising: a determination circuit configured to determine whether denoising is to be performed based on a noise value of the whole input image and an activity evaluation value of the whole input image.", "7.The image processor according to claim 6, wherein the determination circuit is configured to divide the noise value of the whole input image by the activity evaluation value of the whole input image to calculate a noise strength, and determine that denoising is unnecessary if the noise strength is smaller than a predetermined threshold, and that denoising is necessary if the noise strength is larger than or equal to the threshold.", "8.The image processor according to claim 1, wherein the transform circuit, the quantization circuit, and the correction circuit are configured to sequentially process a plurality of blocks extracted from the input image so as to partially overlap each other, and output an optimal value obtained from the blocks overlapping each other as image data of the portion of the output image where the blocks overlap each other.", "9.The image processor according to claim 1, wherein the transform circuit, the quantization circuit, and the correction circuit are configured to sequentially process a plurality of blocks extracted from the input image so as to partially overlap each other, and use output data of the portion of the output image where the blocks overlap each other in processing a current block for input data of the portion of the image in processing a subsequent macroblock.", "10.The image processor according to claim 1, the input image including a plurality of color components, wherein the image processor is configured to individually perform denoising on each color component.", "11.The image processor according to claim 1, the input image including a plurality of color components, wherein the image processor is configured to perform integrated denoising on the plurality of color components.", "12.An image processor configured to perform denoising on an input image to generate an output image, the image processor comprising: a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components; a quantization circuit configured to perform quantization on the second image data to generate third image data, a correction circuit configured to perform correction per frequency component on the third image data to generate fourth image data; an arithmetic circuit configured to calculate a per-block activity evaluation value based on the first image data; and a correction value setting circuit configured to set a per-block correction value for correction based on the per-block activity evaluation value, the correction value setting circuit being configured to hold a plurality of different masks depending on activity evaluation values, the masks containing arbitrary multipliers by frequency components, and set the correction value to a multiplier for one of the masks corresponding to the activity evaluation value calculated by the arithmetic circuit.", "13.The image processor according to claim 12, wherein the correction value setting circuit is configured to set the correction value for a block having a small activity evaluation value to one time for a low-frequency component and to substantially zero time for middle- and high-frequency components, the correction value for a block having a medium activity evaluation value to one time for low- and middle-frequency components and to substantially zero time for a high-frequency component; and the correction value for a block having a large activity evaluation value to one time for low-, middle-, and high-frequency components.", "14.The image processor according to claim 12, further comprising: a smoothing circuit configured to calculate a smoothing value of each pixel based on a pixel value of each pixel and a pixel value of a plurality of adjacent pixels, the arithmetic circuit being configured to calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "15.The image processor according to claim 12, further comprising: a determination circuit configured to determine whether denoising is to be performed based on a noise value of the whole input image and an activity evaluation value of the whole input image.", "16.The image processor according to claim 15, wherein the determination circuit is configured to divide the noise value of the whole input image by the activity evaluation value of the whole input image to calculate a noise strength, and determine that denoising is unnecessary if the noise strength is smaller than a predetermined threshold, and that denoising is necessary if the noise strength is larger than or equal to the threshold.", "17.The image processor according to claim 12, wherein the transform circuit, the quantization circuit, and the correction circuit are configured to sequentially process a plurality of blocks extracted from the input image so as to partially overlap each other, and output an optimal value obtained from the blocks overlapping each other as image data of the portion of the output image where the blocks overlap each other.", "18.The image processor according to claim 12, wherein the transform circuit, the quantization circuit, and the correction circuit are configured to sequentially process a plurality of blocks extracted from the input image so as to partially overlap each other, and use output data of the portion of the output image where the blocks overlap each other in processing a current block for input data of the portion of the image in processing a subsequent macroblock.", "19.The image processor according to claim 12, the input image including a plurality of color components, wherein the image processor is configured to individually perform denoising on each color component.", "20.The image processor according to claim 12, the input image including a plurality of color components, wherein the image processor is configured to perform integrated denoising on the plurality of color components." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>In some embodiments, an image processor performs denoising on an input image to generate an output image.", "The image processor includes a transform circuit that transforms first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including multiple frequency components, a quantization circuit that performs quantization on the second image data to generate third image data, an arithmetic circuit that calculates a per-block activity evaluation value based on the first image data, and a quantization value setting circuit that sets a per-block quantization value for quantization based on the per-block activity evaluation value.", "In some embodiments, an image processor performs denoising on an input image to generate an output image.", "The image processor includes a transform circuit that transforms first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including multiple frequency components, a quantization circuit that performs quantization on the second image data to generate third image data, a first arithmetic circuit that calculates a per-block noise value based on the first image data, and a quantization value setting circuit that sets a per-block quantization value for quantization based on the per-block noise value.", "These and other objects, features, aspects and advantages of the present disclosure will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation U.S. application Ser.", "No.", "15/388,959, filed on Dec. 22, 2016, which is a continuation of U.S. application Ser.", "No.", "14/636,794, filed on Mar.", "3, 2015, which is now U.S. Pat.", "No.", "9,552,628, issued on Jan. 24, 2017, which claims priority from Japanese Patent Application Numbers 2014-049505, 2014-049506, and 2014-049507, each filed on Mar.", "12, 2014.The disclosures of the applications referenced above are incorporated herein by reference herein in their entireties.", "BACKGROUND Technical Field The present disclosure relates to image processors and image processing methods, and more particularly, to denoising devices and denoising methods for removing noise from an input image to generate an output image.", "Related Art Denoising devices in general remove noise from image data of an input image in a spatial region by uniformly applying a spatial filter such as a lowpass filter to remove a high-frequency component on the whole image.", "JPH9-233369A describes a denoising device that applies a median filter around boundaries in an input image while applying a mean filter to other portions.", "SUMMARY In some embodiments, an image processor performs denoising on an input image to generate an output image.", "The image processor includes a transform circuit that transforms first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including multiple frequency components, a quantization circuit that performs quantization on the second image data to generate third image data, an arithmetic circuit that calculates a per-block activity evaluation value based on the first image data, and a quantization value setting circuit that sets a per-block quantization value for quantization based on the per-block activity evaluation value.", "In some embodiments, an image processor performs denoising on an input image to generate an output image.", "The image processor includes a transform circuit that transforms first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including multiple frequency components, a quantization circuit that performs quantization on the second image data to generate third image data, a first arithmetic circuit that calculates a per-block noise value based on the first image data, and a quantization value setting circuit that sets a per-block quantization value for quantization based on the per-block noise value.", "These and other objects, features, aspects and advantages of the present disclosure will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a diagram illustrating a configuration of an image processor according to an embodiment of the present disclosure.", "FIG.", "2 is a flow chart illustrating the sequence of denoising by the image processor.", "FIG.", "3 is a diagram for illustrating setting of a quantization value by a setting circuit.", "FIG.", "4 is a diagram for illustrating setting of a scaling matrix by a setting circuit.", "FIG.", "5 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "6 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "7 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "8 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "9 is a diagram illustrating overlapping.", "FIGS.", "10A to 10C are diagrams for illustrating first setting of the quantization value.", "FIG.", "11 is a diagram for illustrating second setting of the quantization value.", "FIG.", "12 is a diagram illustrating a configuration of the image processor to realize the second setting of the quantization value.", "FIG.", "13 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "14 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "15 is a diagram for illustrating setting of the scaling matrix by the setting circuit.", "FIG.", "16 is a diagram illustrating a configuration of the image processor according to a first modification.", "FIG.", "17 is a flow chart illustrating the sequence of denoising by the image processor according to the first modification.", "FIG.", "18 is a diagram illustrating a configuration of the image processor according to a second modification.", "FIG.", "19 is a flow chart illustrating the sequence of denoising by the image processor according to the second modification.", "DETAILED DESCRIPTION In the following detailed description, for purposes of explanation, numerous specific details are set forth in order to provide a thorough understanding of the disclosed embodiments.", "It will be apparent, however, that one or more embodiments may be practiced without these specific details.", "In other instances, well-known structures and devices are schematically illustrated in order to simplify the drawing.", "According to the above-described general denoising devices, applying a spatial filter only once to an input image produces only low denoising effect.", "Applying a spatial filter multiple times would enhance denoising effect, but then there will be a decrease in resolution, which may cause boundaries to blur, making the whole image rather degraded in image quality.", "Furthermore, applying a spatial filter multiple times results in prolonged processing time, and in increased circuit size with the need for a temporal memory for storing intermediate values.", "The present disclosure is directed to obtaining an image processor and an image processing method that realizes high denoising effect while avoiding image degradation and achieves reduction in processing time and circuit size.", "An image processor according to an aspect of the present disclosure is configured to perform denoising on an input image to generate an output image.", "The image processor includes a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, a quantization circuit configured to perform quantization on the second image data to generate third image data, a first arithmetic circuit configured to calculate a per-block noise value based on the first image data, and a first quantization value setting circuit configured to set a first quantization value per input image for quantization based on a noise value of the whole input image.", "In the image processor, the first quantization value setting circuit sets a first quantization value per input image based on a noise value of the whole input image, and the quantization circuit performs quantization on the second image data to generate third image data.", "Quantization using the first quantization value based on the noise value of the whole input image realizes appropriate denoising depending on a noise level of the whole input image.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In this aspect, a first correction value setting circuit may set the first correction value per input image based on the second image data of the whole input image, and a correction circuit may perform correction per frequency component on the third image data to generate fourth image data.", "Correction per frequency component using the first correction value based on the second image data of the whole input image realizes appropriate denoising depending on a noise level per frequency component.", "In this aspect, the first arithmetic circuit may calculate a sum of absolute difference between a pixel value of each pixel and a smoothing value of each pixel, and calculate an average of the sum of absolute difference in a block as per-block noise value.", "Thus the first arithmetic circuit appropriately obtains the per-block noise value.", "In this aspect, the first quantization value setting circuit may increase a first quantization value with increase in a noise value.", "When the noise value of the whole input image is large, a large first quantization value achieves high denoising effect by quantization.", "When the noise value of the whole input image is small, a small first quantization value avoids image degradation due to quantization.", "In this aspect, a second quantization value setting circuit may set the per-block second quantization value for quantization based on the first quantization value and a per-block activity evaluation value.", "The per-block second quantization value based on the first quantization value based on the noise value of the whole input image and the per-block activity evaluation value realizes appropriate denoising on a per block basis depending on the noise level of the whole input image and the attribute of a block.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In this aspect, the second arithmetic circuit may calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "Thus the second arithmetic circuit appropriately obtains the per-block activity evaluation value.", "In this aspect, the second quantization value setting circuit may set the second quantization value to a quantization value larger than the first quantization value for a block having a small activity evaluation value.", "In a flat portion having a small activity evaluation value where noise is noticeable, a large second quantization value achieves high denoising effect by quantization.", "The second quantization value setting circuit may set the second quantization value to a quantization value smaller than the first quantization value for a block having a large activity evaluation value.", "In an edge or texture portion having a large activity evaluation value, a small second quantization value prevents edge or texture portion from blurring due to quantization, and thus improves image quality.", "In this aspect, the second quantization value setting circuit may set the per-block second quantization value for quantization based on the first quantization value and a per-block noise value.", "The per-block second quantization value based on the first quantization value based on the noise value of the whole input image and the per-block noise value realizes appropriate denoising on a per block basis depending on the noise level of the whole input image and the per-block noise level.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In this aspect, the second quantization value setting circuit may increase the second quantization value with increase in a noise value with the first quantization value being an upper limit.", "For a block having a large noise value, a large second quantization value achieves high denoising effect by quantization.", "For a block having a small noise value, a small second quantization value avoids image degradation due to quantization.", "Providing the upper limit at the first quantization value restricts the difference between the maximum and the minimum second quantization value to a certain range, eliminating or reducing “floppiness”, and thus the image quality is improved as a whole.", "In this aspect, the first correction value setting circuit may set the first correction value to a transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in the ideal image including no noise.", "Such first correction value realizes correction to bring the output image close to the ideal image, and thus improves image quality.", "In this aspect, a second correction value setting circuit may set the per-block second correction value for correction based on the first correction value and the per-block activity evaluation value.", "The per-macroblock second correction value based on the first correction value based on the second image data of the whole input image and the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the frequency component value of the whole input image and the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In this aspect, the second correction value setting circuit may hold a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and perform masking on the first correction value using one of the masks corresponding to the activity evaluation value calculated by the second arithmetic circuit to set the second correction value.", "In consequence, the second correction value depending on the per-block activity evaluation value is obtained simply and appropriately from the first correction value.", "In this aspect, the second correction value setting circuit may set the second correction value for a block having a small activity evaluation value to the first correction value for a low-frequency component, while setting the second correction value to substantially zero for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The second correction value setting circuit may set the second correction value for a block having a large activity evaluation value to the first correction value for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value, masking not to cut off any frequency component realizes correction to sharpen the edge or texture portion, and thus improves image quality.", "The second correction value setting circuit may set the second correction value for a block having a medium activity evaluation value to the first correction value for low- and middle-frequency components while setting the second correction value to substantially zero for a high-frequency component.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In this aspect, a determination circuit may determine whether denoising is to be performed on the basis of the noise value of the whole input image and the activity evaluation value of the whole input image.", "Thus since denoising is performed on an input image that truly requires denoising while denoising on an input image that requires no denoising is avoided, power consumption is reduced.", "In this aspect, the determination circuit may divide the noise value of the whole input image by the activity evaluation value of the whole input image to calculate a noise strength.", "Then if the noise strength is lower than a predetermined threshold, denoising may be determined to be unnecessary, while if the noise strength is higher than or equal to the threshold, denoising may be determined to be necessary.", "Such determination by the determination circuit achieves highly accurate identification of an input image that truly requires denoising.", "In this aspect, the transform circuit and the quantization circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, an optimal value obtained from the plurality of overlapping blocks may be output as image data of the portion of the image.", "Output of optimal value (for example, average) obtained from a plurality of blocks for overlapping portion realizes high denoising effect while avoiding image degradation.", "In this aspect, the transform circuit and the quantization circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, output data in processing a current block may be used for input data of the portion of the image in processing a subsequent macroblock.", "Denoising of the same portion of the image is performed practically multiple times in sequentially processing multiple blocks, achieving a shorter processing time, in comparison with in comparison with denoising by obtaining an optimal value from output values of multiple blocks overlap each other.", "In this aspect, denoising may be individually performed on each color component.", "Individual denoising for each color component of the input image achieves optimal denoising effect for each color component.", "In this aspect, integrated denoising on a plurality of color components may be performed.", "Integrated denoising on multiple color components achieves improved accuracy of noise detection.", "Furthermore, since variation in denoising effect among color components is eliminated or reduced, image quality is improved.", "An image processing method according to another aspect of the present disclosure is an image processing method for denoising of an input image to generate an output image.", "The method includes transforming first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, performing quantization on the second image data to generate third image data, calculating a per-block noise value based on the first image data, and setting a first quantization value per input image for quantization based on a noise value of the whole input image.", "In the method, a first quantization value per input image is set on the basis of the noise value of the whole input image, and quantization is performed on second image data to generate third image data.", "Quantization using the first quantization value based on the noise value of the whole input image realizes appropriate denoising depending on a noise level of the whole input image.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "An image processor according to another aspect of the present disclosure is configured to perform denoising on an input image to generate an output image.", "The image processor includes a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, a quantization circuit configured to perform quantization on the second image data to generate third image data, an arithmetic circuit configured to calculate a per-block activity evaluation value based on the first image data, and a quantization value setting circuit configured to set a per-block quantization value for quantization based on the per-block activity evaluation value.", "In the image processor, the quantization value setting circuit sets a per-block quantization value for quantization based on the per-block activity evaluation value.", "The per-block quantization value based on the per-block activity evaluation value realizes appropriate denoising on a per block basis depending on the attribute of a block.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In this aspect, a correction value setting circuit may set a per-block correction value for correction based on the per-block activity evaluation value.", "The per-block correction value based on the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In this aspect, the arithmetic circuit may calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "Thus the arithmetic circuit appropriately obtains the per-block activity evaluation value.", "In this aspect, the quantization value setting circuit may set a quantization value of a block having a small activity evaluation value to a large value.", "In a flat portion having a small activity evaluation value where noise is noticeable, a large quantization value achieves high denoising effect by quantization.", "The quantization value setting circuit may set a quantization value of a block having a large activity evaluation value to a small value.", "In an edge or texture portion having a large activity evaluation value, a small quantization value prevents edge or texture portion from blurring due to quantization, and thus improves image quality.", "The quantization value setting circuit may set a quantization value of a block having a medium activity evaluation value to a medium value.", "In an image portion other than flat, edge, and texture portions, a medium quantization value avoids excessive or insufficient denoising effect on the image portion.", "An image processor according to another aspect of the present disclosure is configured to perform denoising on an input image to generate an output image.", "The image processor includes a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, a quantization circuit configured to perform quantization on the second image data to generate third image data, a first arithmetic circuit configured to calculate a per-block noise value based on the first image data, and a quantization value setting circuit configured to set a per-block quantization value for quantization based on the per-block noise value.", "In the image processor, the quantization value setting circuit sets a per-block quantization value for quantization based on the per-block noise value.", "The per-block quantization value based on the per-block noise value realizes appropriate denoising on a per block basis depending on the noise level per block.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In this aspect, a correction value setting circuit may set a per-block correction value for correction based on the per-block activity evaluation value.", "The per-block correction value based on the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In this aspect, the first arithmetic circuit may calculate a sum of absolute difference between a pixel value of each pixel and a smoothing value of each pixel, and calculate an average of the sum of absolute difference in a block as per-block noise value.", "Thus the first arithmetic circuit appropriately obtains the per-block noise value.", "In this aspect, the quantization value setting circuit may increase the quantization value with increase in a noise value.", "For a block having a large noise value, a large quantization value achieves high denoising effect by quantization.", "For a block having a small noise value, a small quantization value avoids image degradation due to quantization.", "In this aspect, the second arithmetic circuit may calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "Thus the second arithmetic circuit appropriately obtains the per-block activity evaluation value.", "In this aspect, the correction value setting circuit may hold a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and set the correction value to a multiplier for one of the masks corresponding to the activity evaluation value calculate by the second arithmetic circuit.", "In consequence the correction value depending on the per-block activity evaluation value is obtained simply and appropriately.", "In this aspect, the correction value setting circuit may set the correction value for a block having a small activity evaluation value to one time for a low-frequency component and to substantially zero time for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The correction value setting circuit may set the correction value for a block having a large activity evaluation value to one time for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value, masking not to cut off any frequency component realizes correction to sharpen the edge or texture portion, and thus improves image quality.", "The correction value setting circuit may set the correction value for a block having a medium activity evaluation value to one time for low- and middle-frequency components and to substantially zero time for a high-frequency component.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In this aspect, the determination circuit may determine whether denoising is to be performed on the basis of the noise value of the whole input image and the activity evaluation value of the whole input image.", "Thus since denoising is performed on an input image that truly requires denoising while denoising on an input image that requires no denoising is avoided, power consumption is reduced.", "In this aspect, the determination circuit may divide the noise value of the whole input image by the activity evaluation value of the whole input image to calculate a noise strength.", "Then if the noise strength is lower than a predetermined threshold, denoising may be determined to be unnecessary, while if the noise strength is higher than or equal to the threshold, denoising may be determined to be necessary.", "Such determination by the determination circuit achieves highly accurate identification of an input image that truly requires denoising.", "In this aspect, the transform circuit and the quantization circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, an optimal value obtained from the plurality of overlapping blocks may be output as image data of the portion of the image.", "Output of optimal value (for example, average) obtained from a plurality of blocks for overlapping portion realizes high denoising effect while avoiding image degradation.", "In this aspect, the transform circuit and the quantization circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, output data in processing a current block may be used for input data of the portion of the image in processing a subsequent macroblock.", "Denoising of the same portion of the image is performed practically multiple times in sequentially processing multiple blocks, achieving a shorter processing time, in comparison with in comparison with denoising by obtaining an optimal value from output values of multiple blocks overlap each other.", "In this aspect, denoising may be individually performed on each color component.", "Individual denoising for each color component of the input image achieves optimal denoising effect for each color component.", "In this aspect, integrated denoising on a plurality of color components may be performed.", "Integrated denoising on multiple color components achieves improved accuracy of noise detection.", "Furthermore, since variation in denoising effect among color components is eliminated or reduced, image quality is improved.", "An image processing method according to another aspect of the present disclosure is an image processing method for denoising of an input image to generate an output image.", "The method includes transforming first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, performing quantization on the second image data to generate third image data, calculating a per-block activity evaluation value based on the first image data, and setting a per-block quantization value for quantization based on the per-block activity evaluation value.", "In the method, a per-block quantization value for quantization is set on the basis of a per-block activity evaluation value.", "The per-block quantization value based on the per-block activity evaluation value realizes appropriate denoising on a per block basis depending on the attribute of a block.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "An image processing method according to another aspect of the present disclosure is an image processing method for denoising of an input image to generate an output image.", "The method includes transforming first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, performing quantization on the second image data to generate third image data, calculating a per-block noise value based on the first image data, and setting a per-block quantization value for quantization based on the per-block noise value.", "In the method, a per-block quantization value for quantization may be set on the basis of the per-block noise value.", "The per-block quantization value based on the per-block noise value realizes appropriate denoising on a per block basis depending on the noise level per block.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "An image processor according to another aspect of the present disclosure is configured to perform denoising on an input image to output an output image.", "The image processor includes a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, a quantization circuit configured to perform quantization on the second image data to generate third image data, a correction circuit configured to perform correction per frequency component on the third image data to generate fourth image data, and a first correction value setting circuit configured to set a first correction value per input image for correction based on the second image data of the whole input image.", "The first correction value setting circuit is configured to set the first correction value to a transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in an ideal image including no noise.", "In the image processor, the first correction value setting circuit may set the first correction value per input image based on the second image data of the whole input image, and the correction circuit may perform correction per frequency component on the third image data to generate fourth image data.", "Correction per frequency component using the first correction value based on the second image data of the whole input image realizes appropriate denoising depending on a noise level per frequency component.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "The first correction value setting circuit may set the first correction value to the transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in the ideal image including no noise.", "Such first correction value realizes correction to bring the output image close to the ideal image, and thus improves image quality.", "In this aspect, the second correction value setting circuit may set the per-block second correction value for correction based on the first correction value and the per-block activity evaluation value.", "The per-macroblock second correction value based on the first correction value based on the second image data of the whole input image and the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the frequency component value of the whole input image and the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In this aspect, the second correction value setting circuit may hold a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and perform masking on the first correction value using one of the masks corresponding to the activity evaluation value calculated by the arithmetic circuit to set the second correction value.", "In consequence, the second correction value depending on the per-block activity evaluation value is obtained simply and appropriately from the first correction value.", "In this aspect, the second correction value setting circuit may set the second correction value for a block having a small activity evaluation value to the first correction value for a low-frequency component, while setting the second correction value to substantially zero for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The second correction value setting circuit may set the second correction value for a block having a large activity evaluation value to the first correction value for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value, masking not to cut off any frequency component realizes correction to sharpen the edge or texture portion, and thus improves image quality.", "The second correction value setting circuit may set the second correction value for a block having a medium activity evaluation value to the first correction value for low- and middle-frequency components while setting the second correction value to substantially zero for a high-frequency component.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In this aspect, the arithmetic circuit may calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "Thus the arithmetic circuit appropriately obtains the per-block activity evaluation value.", "An image processor according to another aspect of the present disclosure is configured to perform denoising on an input image to generate an output image.", "The image processor includes a transform circuit configured to transform first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, a quantization circuit configured to perform quantization on the second image data to generate third image data, a correction circuit configured to perform correction per frequency component on the third image data to generate fourth image data, an arithmetic circuit configured to calculate a per-block activity evaluation value based on the first image data, and a correction value setting circuit configured to set a per-block correction value for correction based on the per-block activity evaluation value.", "The correction value setting circuit is configured to hold a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and set the correction value to a multiplier for one of the masks corresponding to the activity evaluation value calculated by the arithmetic circuit.", "In this aspect, the correction value setting circuit sets a per-block correction value for correction based on the per-block activity evaluation value.", "The per-block correction value based on the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "The correction value setting circuit holds a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and sets the correction value to a multiplier for one of the masks corresponding to the activity evaluation value calculated by the arithmetic circuit.", "In consequence the correction value depending on the per-block activity evaluation value is obtained simply and appropriately.", "In this aspect, the correction value setting circuit may set the correction value for a block having a small activity evaluation value to one time for a low-frequency component and to substantially zero time for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The correction value setting circuit may set the correction value for a block having a large activity evaluation value to one time for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value, masking not to cut off any frequency component realizes correction to sharpen the edge or texture portion, and thus improves image quality.", "The correction value setting circuit may set the correction value for a block having a medium activity evaluation value to one time for low- and middle-frequency components and to substantially zero time for a high-frequency component.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In this aspect, the arithmetic circuit may calculate a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a block and calculate an average of the sum of absolute difference in the block to obtain a per-block activity evaluation value.", "Thus the arithmetic circuit appropriately obtains per-block activity evaluation value.", "In this aspect, the determination circuit may determine whether denoising is to be performed on the basis of the noise value of the whole input image and the activity evaluation value of the whole input image.", "Thus since denoising is performed on an input image that truly requires denoising while denoising on an input image that requires no denoising is avoided, power consumption is reduced.", "In this aspect, the determination circuit may divide the noise value of the whole input image by the activity evaluation value of the whole input image to calculate a noise strength.", "Then if the noise strength is lower than a predetermined threshold, denoising may be determined to be unnecessary, while if the noise strength is higher than or equal to the threshold, denoising may be determined to be necessary.", "Such determination by the determination circuit achieves highly accurate identification of an input image that truly requires denoising.", "In this aspect, the transform circuit, the quantization circuit, and the correction circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, an optimal value obtained from the plurality of overlapping blocks may be output as image data of the portion of the image.", "Output of optimal value (for example, average) obtained from a plurality of blocks for overlapping portion realizes high denoising effect while avoiding image degradation.", "In this aspect, the transform circuit, the quantization circuit, and the correction circuit may sequentially process a plurality of partially-overlapping blocks extracted from the input image.", "Partially overlapping blocks one another eliminates or reduces block noise.", "For a portion of the output image where a plurality of blocks overlap each other, output data in processing a current block may be used for input data of the portion of the image in processing a subsequent macroblock.", "Denoising of the same portion of the image is performed practically multiple times in sequentially processing multiple blocks, achieving a shorter processing time, in comparison with in comparison with denoising by obtaining an optimal value from output values of multiple blocks overlap each other.", "In this aspect, denoising may be individually performed on each color component.", "Individual denoising for each color component of the input image achieves optimal denoising effect for each color component.", "In this aspect, integrated denoising on a plurality of color components may be performed.", "Integrated denoising on multiple color components achieves improved accuracy of noise detection.", "Furthermore, since variation in denoising effect among color components is eliminated or reduced, image quality is improved.", "An image processing method according to another aspect of the present disclosure is an image processing method for denoising of an input image to output an output image.", "The method includes transforming first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, performing quantization on the second image data to generate third image data, performing correction per frequency component on the third image data to generate fourth image data, and setting a first correction value per input image for correction based on the second image data of the whole input image.", "The setting of the first correction value includes setting the first correction value to a transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in an ideal image including no noise.", "In the image processing method, the setting of the first correction value includes setting the first correction value per input image based on the second image data of the whole input image, and the performing correction on the third image data includes performing correction per frequency component on the third image data to generate fourth image data.", "Correction per frequency component using the first correction value based on the second image data of the whole input image realizes appropriate denoising depending on a noise level per frequency component.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "The setting of the first correction value further includes setting the first correction value to a transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in an ideal image including no noise.", "Such first correction value realizes correction to bring the output image close to the ideal image, and thus improves image quality.", "An image processing method according to another aspect of the present disclosure is an image processing method for denoising of an input image to generate an output image.", "The method includes transforming first image data of a spatial region extracted from the input image in a unit of a predetermined block into second image data of a frequency region including a plurality of frequency components, performing quantization on the second image data to generate third image data, performing correction per frequency component on the third image data to generate fourth image data, calculating a per-block activity evaluation value based on the first image data, and setting a per-block correction value for correction based on the per-block activity evaluation value.", "The setting of the correction value includes holding a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and setting the correction value to a multiplier for one of the masks corresponding to the activity evaluation value calculate in the calculating of the per-block activity evaluation value.", "The image processing method includes setting a per-block correction value for correction based on the per-block activity evaluation value.", "The per-block correction value based on the per-block activity evaluation value realizes appropriate correction on a per block basis depending on the attribute of a block.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "The method includes holding a plurality of different masks depending on the activity evaluation value, the masks containing arbitrary multipliers by frequency components, and setting the correction value to a multiplier for one of the masks corresponding to the activity evaluation value calculate in the calculating of the per-block activity evaluation value.", "In consequence the correction value depending on the per-block activity evaluation value is obtained simply and appropriately.", "Some embodiments of the present disclosure provide an image processor and an image processing method that realize high denoising effect while avoiding image degradation and achieve reduction in processing time and circuit size.", "DESCRIPTION OF EMBODIMENTS Embodiments of the present disclosure are described in detail below referring to the drawings.", "It should be noted that identical reference numerals throughout the drawings indicate identical or equivalent elements.", "FIG.", "1 is a diagram illustrating a configuration of an image processor 1 according to an embodiment of the present disclosure.", "The image processor 1 receives an input image including R, Gr, Gb, and B color components in Bayer array sorted by color components.", "The image processor 1 performs denoising individually on the input image of each color component, so as to generate and output an output image.", "Color components of the input image are not limited to R, Gr, Gb, and B but may be R, G, and, B, Y, U, and V, or the like.", "FIG.", "1 illustrates a relation of connection of the image processor 1 including a transform circuit 11, a quantization circuit 12, a correction circuit 13, an inverse quantization circuit 14, an inverse transform circuit 15, a selector 16, a setting circuit 17, a filter circuit 18, arithmetic circuits 19 and 20, and setting circuits 21 to 24.The transform circuit 11 transforms image data D1 of a spatial region extracted from an input image in a unit of a predetermined block (in this example, macroblock by macroblock, each macroblock having 8 rows×8 columns) into image data D2 of a frequency region including multiple frequency components by DCT transform.", "The block size is not limited to 8 rows×8 columns but may be, for example, 16 rows×16 columns.", "With a bigger block size, the circuit size increases, but the image quality is improved with finer control over frequency components.", "The quantization circuit 12 performs quantization on image data D2 to generate image data D3.The correction circuit 13 performs correction per frequency component on the image data D3 to generate image data D4.The inverse quantization circuit 14 performs inverse quantization on the image data D4 to generate image data D5.The inverse transform circuit 15 transforms the image data D5 of a frequency region into image data D6 of a spatial region by inverse DCT transform.", "The selector 16 selects and outputs the image data D1 or the image data D6.A CPU 2 determines whether denoising is to be performed, on the basis of a noise value of the whole input image NOISE(PIC) and an activity evaluation value of the whole input image ACT(PIC).", "A result of the determination is configured in the setting circuit 17.The setting circuit 17 causes the selector 16 to select the image data D6 if denoising is necessary, while causing the selector 16 to select the image data D1 if denoising is unnecessary.", "The filter circuit 18 is an arbitrary smoothing filter (in this example, the Gaussian filter having 3 rows×3 columns), which calculates a weighted mean GAUS (i, j) of each pixel, on the basis of a pixel value of each pixel and pixel values of multiple adjacent pixels (eight pixels for 3 rows×3 columns).", "The arithmetic circuit 19 calculates a per-macroblock noise value NOISE(MB), on the basis of the image data D1 and the image data D1 processed by the filter circuit 18 with a weighted mean.", "The arithmetic circuit 19 also calculates an average of noise values NOISE(MB) of all macroblocks in the input image which serves as a noise value NOISE(PIC).", "The noise value NOISE(PIC) may be calculated by inputting a sum of the noise values NOISE(MB) of all macroblocks in the input image from the arithmetic circuit 19 to the CPU 2 and dividing the sum by the number of macroblocks in the CPU 2.The arithmetic circuit 20 calculates a per-macroblock activity evaluation value ACT(MB), on the basis of the image data D1 processed by the filter circuit 18 with a weighted mean.", "The arithmetic circuit 20 also calculates an average of activity evaluation values ACT(MB) of all macroblocks in the input image which serves as an activity evaluation value ACT(PIC).", "The activity evaluation value ACT(PIC) may be calculated by inputting a sum of the activity evaluation values ACT(MB) of all macroblocks in the input image from the arithmetic circuit 20 to the CPU 2 and dividing the sum by the number of macroblocks in the CPU 2.The setting circuit 21 sets a quantization value QP(PIC) per input image for quantization by the quantization circuit 12, on the basis of the noise value NOISE(PIC).", "The setting circuit 22 sets a per-macroblock quantization value QP(MB) for quantization by the quantization circuit 12, on the basis of an internal parameter of the image processor 1 (for example, the quantization value QP(PIC), the activity evaluation value ACT(MB), and the noise value NOISE(MB)).", "The setting circuit 23 sets a scaling matrix SM(PIC) that contains a correction value per input image for correction by the correction circuit 13, on the basis of the image data D2 of the whole input image.", "The setting circuit 24 sets a scaling matrix SM(MB) that contains a per-macroblock correction value for correction by the correction circuit 13, on the basis of an internal parameter of the image processor 1 (for example, the scaling matrix SM(PIC), the activity evaluation value ACT(MB), the noise value NOISE(PIC), and the activity evaluation value ACT(PIC)).", "FIG.", "2 is a flow chart illustrating the sequence of denoising by the image processor 1.Firstly in Step P101, the setting circuit 17 sets the selector 16, in accordance with determination by the CPU 2 as to whether denoising is to be performed.", "If denoising is unnecessary, processing ends.", "If denoising is necessary, in Step P102, the setting circuit 21 sets the quantization value QP(PIC).", "In Step P103, the setting circuit 23 set the scaling matrix SM(PIC).", "In Steps P104 to P110, per-macroblock denoising is repeated for all macroblocks in the input image.", "In Step Pl04, the arithmetic circuit 20 calculates the activity evaluation value ACT(MB).", "In Step P105, the setting circuit 22 sets the quantization value QP(MB).", "The setting circuit 24 also sets the scaling matrix SM(MB).", "In Step P106, the transform circuit 11 transforms the image data D1 into the image data D2.In Step P107, the quantization circuit 12 performs quantization using the quantization value QP(MB) on the image data D2 to generate the image data D3.In Step P108, the correction circuit 13 performs correction using the scaling matrix SM(MB) on the image data D3 to generate the image data D4.In Step P109, the inverse quantization circuit 14 performs inverse quantization on the image data D4 to generate the image data D5.In Step P110, the inverse transform circuit 15 transforms the image data D5 into the image data D6 by inverse DCT transform.", "Processing ends with completion of per-macroblock denoising for all macroblocks in the input image.", "Description is given of details of processing by each processing unit illustrated in FIG.", "1.<Calculation of GAUS (i, j)> The filter circuit 18 calculates a weighted mean GAUS (i, j) of each pixel given by Equation 1, where CURR (i, j) is a pixel value of each pixel in a macroblock: Equation   1 GAUS  ( i , j ) = CURR  ( i , j ) * [ 1 2 1 2 4 2 1 2 1 ] // 16 ( 1 ) <Calculation of NOISE(MB)> The arithmetic circuit 19 calculates a sum of absolute difference between the pixel value CURR (i, j) of each pixel and the weighted mean GAUS (i, j) of each pixel given by Equation 2.Then the arithmetic circuit 19 calculates an average of the sum of absolute difference in the macroblock given by Equation 3, which serves as the per-macroblock noise value NOISE(MB).", "Equation   2 diff_  8 × 8  blk = ∑ j = 0 7  ∑ i = 0 7   CURR  ( i , j ) - GAUS  ( i , j )  ( 2 ) Equation   3 NOISE  ( MB ) = diff_  8 × 8  blk // 64 ( 3 ) <Setting of QP(PIC)> FIG.", "3 is a diagram for illustrating setting of the quantization value QP(PIC) by the setting circuit 21.The arithmetic circuit 19 calculates an average of noise values NOISE(MB) of all macroblocks in the input image, which serves as the noise value NOISE(PIC).", "The setting circuit 21 holds a look-up table containing an optimal quantization value QP(PIC) for each noise value NOISE(PIC).", "The setting circuit 21 normalizes the look-up table in the distribution range of the weighted means GAUS (i, j) in the histogram of the weighted means GAUS (i, j) and the number of pixels.", "Then the setting circuit 21 uses the normalized look-up table to set the quantization value QP(PIC) of the input image to the quantization value corresponding to the noise value NOISE(PIC).", "As illustrated in FIG.", "3, the setting circuit 21 increases the quantization value QP(PIC) with increase in the noise value NOISE(PIC).", "<Setting of SM(PIC)> FIGS.", "4 to 8 are diagrams for illustrating setting of the scaling matrix SM(PIC) by the setting circuit 23.The setting circuit 23 firstly obtains the quantization value QP(PIC) in the same method as the setting circuit 21.The setting circuit 23 then acquires image data D3 on which DCT transform and quantization with the quantization value QP(PIC) have been performed, for all macroblocks in the input image.", "Absolute values of frequency component values of all macroblocks are accumulated for each frequency component in the image data D3 to obtain a sum of absolute difference K1 of each frequency component value of the input image.", "An example of the sum of absolute difference K1 is illustrated in FIG.", "4.The frequency component value at the top-left corner as oriented in the figure corresponds to a DC component, and the frequency component value at the bottom-right corner corresponds to a component having the highest frequency.", "The setting circuit 23 acquires the image data D2 on which DCT transform has been performed, for all macroblocks in an ideal image prepared in advance.", "The ideal image is an image that includes no noise in which a subject is shot in the same composition as the input image.", "For example, when the image processor 1 is used for a security camera, the input image is an image with much noise shot under low illumination such as at nighttime, while the ideal image is an image with little noise shot under high illumination such as at daytime.", "The setting circuit 23 accumulates absolute values of frequency component values of all macroblocks for each frequency component in the image data D2 to obtain a sum of absolute difference K2 of each frequency component value of the ideal image.", "An example of the sum of absolute difference K2 is illustrated in FIG.", "5.The setting circuit 23 then normalizes each frequency component value of the sum of absolute difference K2 to have the frequency component value of the DC component of the sum of absolute difference K2 equal to that of the sum of absolute difference K1, so as to produce a normalized sum of absolute difference K3.An example of the sum of absolute difference K3 is illustrated in FIG.", "6.The setting circuit 23 then calculates a transform value (multiplier) for transforming the sum of absolute difference K1 of each frequency component value so that each frequency component value of the sum of absolute difference K1 equals to (or approaches) each frequency component value of the sum of absolute difference K3.In other words, the setting circuit 23 sets the correction value to the transform value for transforming each frequency component value in the input image so that a ratio of each frequency component value to the DC component in the input image equals to that in the ideal image.", "The setting circuit 23 then employs predetermined coefficients for substituting for the multipliers of the frequency components to produce the scaling matrix SM(PIC).", "An example of the scaling matrix SM(PIC) is illustrated in FIG.", "7.An example of a correspondence between coefficients and multipliers is illustrated in FIG.", "8.In the scaling matrix SM(PIC), the coefficient “16” corresponds to the multiplier “1” (that is, passed through) and the coefficient “255” corresponds to the smallest multiplier being substantially zero (that is, cut off).", "If the ideal image is not available, the coefficient “16” is employed for all frequency components, so as to produce the scaling matrix SM(PIC) that causes the correction circuit 13 to practically serve as a through filter.", "Alternatively, the scaling matrix SM(PIC) for general-purpose use may be prepared in advance, and such scaling matrix SM(PIC) may be used if the ideal image is not available.", "<Overlapping> In the image processor 1, overlapping of macroblocks is performed on a macroblock having 8 rows×8 columns with a subsequent macroblock extracted from a position shifted by four pixels serving as the image data D1.The number of pixels for the shift is not limited to four, but may be an arbitrary number.", "With a shift by fewer pixels, processing time elongates, but the image quality is improved.", "FIG.", "9 is a diagram illustrating overlapping.", "FIG.", "9 illustrates the input image having 16 rows×16 columns to facilitate the description.", "Firstly a macroblock MB1 is extracted, starting from the top-left corner, as oriented in the figure, of the input image.", "Then a macroblock MB2 is extracted, from the position shifted row-wise by four pixels from the macroblock MB1.Then a macroblock MB3 is extracted from the position shifted row-wise by four pixels from the macroblock MB2.Then a macroblock MB4 is extracted from the position shifted column-wise by four pixels from the macroblock MB1.From then on, macroblocks MB5 to MB9 are similarly extracted in sequence.", "Thus the transform circuit 11, the quantization circuit 12, the correction circuit 13, the inverse quantization circuit 14, and the inverse transform circuit 15 sequentially process partially-overlapping multiple macroblocks MB1 to MB9 extracted from the input image.", "For a portion of the output image where multiple macroblocks overlap each other, an optimal value (in this example, an average) obtained from the overlapping multiple macroblocks is output as image data of this portion.", "For example, four macroblocks MB1, MB2, MB4, and MB5 overlap each other in the portion having 4 rows×4 columns of the image colored gray in FIG.", "9, and thus image data D6 is obtained for each of these four macroblocks.", "Thus the image data D6 of this portion of these four macroblocks are added together, and the value obtained by the addition is divided by four, which is the number of macroblocks overlapping each other, so that an average of the image data D6 of the multiple macroblocks overlapping each other is calculated.", "Then the average is output from the image processor 1 as the image data D6 of this portion of the image.", "As a first modification of overlapping, the above optimal value may be, instead of the above average, an output value (image data D6) of a macroblock having the smallest noise value NOISE(MB) among multiple macroblocks overlapping each other.", "As a second modification of overlapping, for a portion of the image where multiple macroblocks overlap each other, an output value of this portion of the image obtained in processing a current macroblock may be used for an input value of this portion of the image for processing a subsequent macroblock.", "For example, regarding the portion having 4 rows×4 columns of the image colored gray in FIG.", "9, an output value (image data D6) obtained in processing the macroblock MB1 is used for an input value (image data D1) for processing the macroblock MB2, an output value obtained in processing the macroblock MB2 is used for an input value for processing the macroblock MB4, and an output value obtained in processing the macroblock MB4 is used for an input value for processing the macroblock MB5.In this method, denoising of the same portion of the image is performed practically multiple times in sequentially processing multiple macroblocks, achieving a shorter processing time, in comparison with denoising by obtaining an average of multiple output values.", "<Calculation of ACT(MB)> The arithmetic circuit 20 calculates an average AVE_BLK of weighted means in a macroblock given by Equation 4.Then the arithmetic circuit 20 calculates a sum of absolute difference between the weighted mean GAUS (i, j) of each pixel and the average AVE_BLK in the macroblock given by Equation 5.Then the arithmetic circuit 20 calculates an average of the sum of absolute difference in the macroblock given by Equation 6, which serves as the per-macroblock activity evaluation value ACT(MB).", "Equation   4 AVE_BLK = ( ∑ j = 0 7  ∑ i = 0 7  GAUS  ( i , j ) ) // 64 ( 4 ) Equation   5 vari_  8 × 8  blk = ∑ j = 0 7  ∑ i = 0 7   GAUS  ( i , j ) - AVE_BLK  ( 5 ) Equation   6 ACT  ( MB ) = vari_  8 × 8  blk // 64 ( 6 ) <First Setting of QP(MB)> FIGS.", "10A to 10C are diagrams for illustrating first setting of the quantization value QP(MB) by the setting circuit 22.The setting circuit 22 sets the quantization value QP(MB) on the basis of the quantization value QP(PIC) and the activity evaluation value ACT(MB).", "The setting circuit 22 holds a look-up table containing an optimal quantization value QP(MB) for each activity evaluation value ACT(MB).", "As illustrated in FIGS.", "10A and 10B, the setting circuit 22 normalizes the look-up table in a distribution range of the activity evaluation value ACT(MB), in the histogram of the activity evaluation value ACT(MB) and the number of macroblocks.", "As illustrated in FIG.", "10B, according to the look-up table, the quantization value QP(MB) decreases with increase in the activity evaluation value ACT(MB).", "As illustrated in FIG.", "10C, the setting circuit 22 sets an upper-limit quantization value QPH to a value larger than the quantization value QP(PIC) by AH and a lower-limit quantization value QPL to a value smaller than the quantization value QP(PIC) by ΔL.", "Then the setting circuit 22 sets the quantization value QP(MB) of a macroblock whose quantization value QP(MB) in FIG.", "10B exceeds the upper-limit quantization value QPH, which is a macroblock having a small activity evaluation value ACT(MB) (smaller than value A1), to the upper-limit quantization value QPH.", "The quantization value QP(MB) of a macroblock whose quantization value QP(MB) in FIG.", "10B is smaller than or equal to the upper-limit quantization value QPH and larger than or equal to the lower-limit quantization value QPL, which is a macroblock having a medium activity evaluation value ACT(MB) (larger than or equal to value A1 and smaller than or equal to value A2), is set to the quantization value QP(MB) in FIG.", "10B without change.", "The quantization value QP(MB) of a macroblock whose quantization value QP(MB) in FIG.", "10B is smaller than the lower-limit quantization value QPL, which is a macroblock having a large activity evaluation value ACT(MB) (larger than value A2), is set to the lower-limit quantization value QPL.", "<Second Setting of QP(MB)> FIG.", "11 is a diagram for illustrating second setting of the quantization value QP(MB) by the setting circuit 22.The setting circuit 22 sets the quantization value QP(MB) on the basis of the quantization value QP(PIC) and the noise value NOISE(MB).", "The setting circuit 22 calculates the quantization value QP(VIB) given by Equation 7 on the basis of the noise value NOISE(MB).", "As illustrated in FIG.", "11, the setting circuit 22 increases the quantization value QP(MB) with increase in the noise value NOISE(MB).", "Equation 7 QP(MB)=gain*(6*log 2(NOISE(MB)))+offset (7) The setting circuit 22 uses the quantization value QP(PIC) for the upper limit of the quantization value QP(MB), so that if the quantization value QP(MB) given by Equation 7 exceeds the quantization value QP(PIC), the quantization value QP(MB) is set to the quantization value QP(PIC).", "FIG.", "12 is a diagram illustrating a configuration of the image processor 1 to realize the second setting of the quantization value QP(MB).", "The noise value NOISE(MB) is input from the arithmetic circuit 19 to the setting circuit 22.The quantization value QP(PIC) can be calculated by replacing the noise value NOISE(MB) in Equation 7 by noise value NOISE(PIC).", "Thus the setting circuit 21 may set the quantization value QP(PIC) using an operation in accordance with Equation 7, instead of the look-up table illustrated in FIG.", "3.<Setting of SM(MB)> FIGS.", "13 to 15 are diagrams for illustrating setting of the scaling matrix SM(MB) by the setting circuit 24.The setting circuit 24 sets the scaling matrix SM(MB) on the basis of the scaling matrix SM(PIC) and the activity evaluation value ACT(MB).", "Referring to FIG.", "13, the setting circuit 24 performs masking on the scaling matrix SM(PIC) with a low-level mask ML for a macroblock having a small activity evaluation value ACT(MB) (smaller than value A1).", "The mask ML has a mask value for passing through a low-frequency component with a multiplier “1” and cutting off middle- and high-frequency components with a multiplier being substantially zero.", "Thus the correction value of the scaling matrix SM(MB) for low-frequency components is set to that of the scaling matrix SM(PIC) and the correction value of the scaling matrix SM(MB) for middle- and high-frequency components is set to substantially zero.", "Referring to FIG.", "14, the setting circuit 24 performs masking on the scaling matrix SM(PIC) with a middle-level mask MM for a macroblock having a medium activity evaluation value ACT(MB) (larger than or equal to value A1 and smaller than or equal to value A2).", "The mask MM has a masking value for passing through low- and middle-frequency components with a multiplier “1” and cutting off a high-frequency component with a multiplier being substantially zero.", "Thus the correction value of the scaling matrix SM(MB) for low- and middle-frequency components is set to that of the scaling matrix SM(PIC) and the correction value of the scaling matrix SM(MB) for a high-frequency component is set to substantially zero.", "Referring to FIG.", "15, the setting circuit 24 performs masking on the scaling matrix SM(PIC) with a high-level mask MH for a macroblock having a large activity evaluation value ACT(MB) (larger than value A2).", "The mask MH has a mask value for passing through low-, middle-, and high-frequency components with a multiplier “1”.", "Thus the correction value of the scaling matrix SM(MB) for all low-, middle-, and high-frequency components is set to that of the scaling matrix SM(PIC).", "Masking of three scales with three masks ML, MM, and MH is described above as an example, while masking of four or more scales (for example, eight scales) may be possible by preparing four or more masks depending on a variable such as the activity evaluation value ACT(MB).", "Furthermore, the multiplier of each of the masks ML, MM, and MH illustrated in FIGS.", "13 to 15 is only a non-limiting example.", "The multiplier of each of the masks ML, MM, and MH can be set to an arbitrary value depending on, for example, an amount of noise.", "<Determination Whether Denoising is to be Performed> The arithmetic circuit 19 calculates an average of the noise values NOISE(MB) of all macroblocks in the input image which serves as the noise value NOISE(PIC), and inputs the noise value NOISE(PIC) to the CPU 2.The arithmetic circuit 20 also calculates an average of the activity evaluation values ACT(MB) of all macroblocks in the input image which serves as the activity evaluation value ACT(PIC), and inputs the activity evaluation value ACT(PIC) to the CPU 2.The CPU 2 determines whether denoising is to be performed for each input image, on the basis of the noise value NOISE(PIC) of the whole input image and the activity evaluation value ACT(PIC) of the whole input image.", "The CPU 2 divides the noise value NOISE(PIC) by the activity evaluation value ACT(PIC) (NOISE(PIC)/ACT(PIC)) to calculate a noise strength.", "Then if the noise strength is lower than a predetermined threshold (for example, “1”), denoising is determined to be unnecessary, while if the noise strength is higher than or equal to the threshold, denoising is determined to be necessary.", "Thus controlling ON/OFF of denoising in a unit of a picture achieves reduction in power consumption.", "If delay time in processing is not a problem, for example, when the input image is a still picture, the CPU 2 can calculate the noise value NOISE(PIC) and the activity evaluation value ACT(PIC) of the input image itself, and on the basis of them, determine whether denoising is to be performed.", "In contrast, if delay time in processing is a problem, for example, when the input image is a moving picture, the CPU 2 can determine whether denoising is to be performed on a current input image, on the basis of the noise value NOISE(PIC) and the activity evaluation value ACT(PIC) of an immediately preceding input image (i.e., image of one frame before).", "First Modification In the above embodiment, the quantization value is set on the basis of both the quantization value QP(PIC) and the quantization value QP(MB), and the correction value is set on the basis of both the scaling matrix SM(PIC) and the scaling matrix SM(MB), but the quantization value may be set on the basis of the quantization value QP(PIC) only, and the correction value may be set on the basis of the scaling matrix SM(PIC) only.", "FIG.", "16 is a diagram illustrating a configuration of the image processor 1 according to the present modification.", "The setting circuits 22 and 24 are omitted from the configuration illustrated in FIG.", "1.FIG.", "17 is a flow chart illustrating the sequence of denoising by the image processor 1 according to the present modification.", "Firstly in Step P201, the setting circuit 17 sets the selector 16, in accordance with determination by the CPU 2 as to whether denoising is to be performed.", "If denoising is unnecessary, processing ends.", "If denoising is necessary, in Step P202, the setting circuit 21 sets the quantization value QP(PIC).", "In Step P203, the setting circuit 23 sets the scaling matrix SM(PIC).", "In Steps P204 to P208, per-macroblock denoising is repeated for all macroblocks in the input image.", "In Step P204, the transform circuit 11 transforms the image data D1 into the image data D2.In Step P205, the quantization circuit 12 performs quantization using the quantization value QP(PIC) on the image data D2 to generate the image data D3.In Step P206, the correction circuit 13 performs correction using the scaling matrix SM(PIC) on the image data D3 to generate the image data D4.In Step P207, the inverse quantization circuit 14 performs inverse quantization on the image data D4 to generate the image data D5.In Step P208, the inverse transform circuit 15 transforms the image data D5 into the image data D6 by inverse DCT transform.", "Processing ends with completion of per-macroblock denoising for all macroblocks in the input image.", "Second Modification In the above embodiment, the quantization value is set on the basis of both the quantization value QP(PIC) and the quantization value QP(MB), and the correction value is set on the basis of both the scaling matrix SM(PIC) and the scaling matrix SM(MB), but the quantization value may be set on the basis of the quantization value QP(MB) only, and the correction value may be set on the basis of the scaling matrix SM(MB) only.", "FIG.", "18 is a diagram illustrating a configuration of the image processor 1 according to the present modification.", "The setting circuits 21 and 23 are omitted from the configuration illustrated in FIG.", "1.FIG.", "19 is a flow chart illustrating the sequence of denoising by the image processor 1 according to the present modification.", "Firstly in Step P301, the setting circuit 17 sets the selector 16, in accordance with determination by the CPU 2 as to whether denoising is to be performed.", "If denoising is unnecessary, processing ends.", "In Steps P302 to P308, per-macroblock denoising is repeated for all macroblocks in the input image.", "In Step P302, the arithmetic circuit 20 calculates the activity evaluation value ACT(MB).", "In Step P303, the setting circuit 22 sets the quantization value QP(MB).", "The setting circuit 24 also sets the scaling matrix SM(MB).", "In the present modification, the setting circuit 24 uses the low-level mask ML (FIG.", "13) as the scaling matrix SM(MB) for a macroblock having a small activity evaluation value ACT(MB)(smaller than value A1).", "For a macroblock having a medium activity evaluation value ACT(MB) (larger than or equal to value A1 and smaller than or equal to value A2), the setting circuit 24 uses the middle-level mask MM (FIG.", "14) as the scaling matrix SM(MB).", "For a macroblock having a large activity evaluation value ACT(MB) (larger than value A2), the setting circuit 24 uses the high-level mask MH (FIG.", "15) as the scaling matrix SM (MB).", "In Step P304, the transform circuit 11 transforms the image data D1 into the image data D2.In Step P305, the quantization circuit 12 performs quantization using the quantization value QP(MB) on the image data D2 to generate the image data D3.In Step P306, the correction circuit 13 performs correction on the scaling matrix SM(MB) on the image data D3 to generate the image data D4.In Step P307, the inverse quantization circuit 14 performs inverse quantization on the image data D4 to generate the image data D5.In Step P308, the inverse transform circuit 15 transforms the image data D5 into the image data D6 by inverse DCT transform.", "Processing ends with completion of per-macroblock denoising for all macroblocks in the input image.", "Third Modification In the above embodiment, the denoising is individually performed on each color component of the input image, but integrated denoising on all (or part of multiple) color components may be performed.", "The arithmetic circuit 19 averages the noise values NOISE(PIC) of each color component to calculate an average noise value NOISE(PIC) of all color components.", "The arithmetic circuit 20 averages the activity evaluation values ACT(PIC) of each color component to calculate an average activity evaluation value ACT(PIC) of all color components.", "The arithmetic circuit 19 averages the noise values NOISE(MB) of each color component to calculate an average noise value NOISE(MB) of all color components.", "The arithmetic circuit 20 averages the activity evaluation values ACT(MB) of each color component to calculate an average activity evaluation value ACT(MB) of all color components.", "These average noise values NOISE(PIC) and NOISE(MB) and average activity evaluation values ACT(PIC) and ACT(MB) are used to set common quantization values QP(PIC) and QP(MB) and common scaling matrices SM(PIC) and SM(MB) common to all color components to perform integrated denoising.", "Thus integrated denoising performed on all (or part of multiple) color component achieves improved accuracy of noise detection.", "Furthermore, since variation in denoising effect among color components is eliminated or reduced, image quality is improved.", "On the other hand, individual denoising for each color component of the input image as in the above embodiment achieves optimal denoising effect for each color component.", "If the amount of noise significantly differs among color components, such as when the amount of noise of only some of color components is outstanding, the method according to above embodiment is effective.", "Fourth Modification In the above embodiment, the image processor 1 is configured as hardware such as a dedicated LSI.", "Instead of this configuration, a function similar to that of the image processor 1 can be realized by software processing by the CPU 2 that reads and executes a program stored in a recording medium such as a ROM.", "<Recapitulation> In the image processor 1 according to the above embodiment and first modification, the setting circuit 21 (first quantization value setting circuit) sets quantization value QP(PIC) (first quantization value) per input image on the basis of the noise value NOISE(PIC) of the whole input image, and the quantization circuit 12 performs quantization on the image data D2 (second image data) to generate the image data D3 (third image data).", "Quantization using the quantization value QP(PIC) based on the noise value NOISE(PIC) of the whole input image realizes appropriate denoising depending on a noise level of the whole input image.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In the image processor 1 according to the above embodiment and first modification, the setting circuit 23 (first correction value setting circuit) sets the scaling matrix SM(PIC) (first correction value) per input image on the basis of the image data D2 of the whole input image, and the correction circuit 13 performs correction per frequency component on the image data D3 to generate the image data D4 (fourth image data).", "Correction on a per frequency component basis using the scaling matrix SM(PIC) based on the image data D2 of the whole input image realizes appropriate denoising depending on a noise level per frequency component.", "In the image processor 1 according to the above embodiment, the arithmetic circuit 19 (first arithmetic circuit) calculates a sum of absolute difference between a pixel value of each pixel and a smoothing value (weighted mean in the above example) of each pixel, and calculates an average of the sum of absolute difference in a macroblock to obtain a per-macroblock noise value NOISE(MB).", "Thus the arithmetic circuit 19 appropriately obtains the noise value NOISE(MB) on a per macroblock basis.", "In the image processor 1 according to the above embodiment, the setting circuit 21 increases the quantization value QP(PIC) with increase in a noise value.", "When the noise value NOISE(PIC) of the whole input image is large, a large quantization value QP(PIC) achieves high denoising effect by quantization.", "When the noise value NOISE(PIC) of the whole input image is small, a small quantization value QP(PIC) avoids image degradation due to quantization.", "In the image processor 1 according to the above embodiment, the setting circuit 22 (second quantization value setting circuit) sets the per-macroblock quantization value QP(MB) (second quantization value) for quantization, on the basis of the quantization value QP(PIC) and the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock quantization value QP(MB) based on the quantization value QP(PIC) based on the noise value NOISE(PIC) of the whole input image and the per-macroblock activity evaluation value ACT(MB) realizes appropriate denoising on a per macroblock basis depending on the noise level of the whole input image and the attribute of a macroblock.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the arithmetic circuit 20 (second arithmetic circuit) calculates a sum of absolute difference between a smoothing value of each pixel and an average smoothing value in a macroblock, and calculates an average of the sum of absolute difference in the macroblock to obtain the per-macroblock activity evaluation value ACT(MB).", "Thus the arithmetic circuit 20 appropriately obtains the activity evaluation value ACT(MB) on a per macroblock basis.", "In the image processor 1 according to the above embodiment, the setting circuit 22 sets the quantization value QP(MB) of a macroblock having a small activity evaluation value ACT(MB) to a quantization value larger than the quantization value QP(PIC).", "In a flat portion having a small activity evaluation value ACT(MB) where noise is noticeable, a large quantization value QP(MB) achieves high denoising effect by quantization.", "The setting circuit 22 sets the quantization value QP(MB) of a macroblock having a large activity evaluation value ACT(MB) to a quantization value smaller than the quantization value QP(PIC).", "In an edge or texture portion having a large activity evaluation value ACT(MB), a small quantization value QP(MB) prevents the edge or texture portion from blurring due to quantization, and thus improves image quality.", "The setting circuit 22 sets the quantization value QP(MB) of a macroblock having a medium activity evaluation value ACT(MB) to a value similar to the quantization value QP(PIC).", "In an image portion other than flat, edge, and texture portions, a medium quantization value QP(MB) avoids excessive or insufficient denoising effect on the image portion.", "In the image processor 1 according to the above embodiment, the setting circuit 22 sets a per-macroblock quantization value QP(MB) for quantization, on the basis of the quantization value QP(PIC) and the per-macroblock noise value NOISE(MB).", "The per-macroblock quantization value QP(MB) based on the quantization value QP(PIC) based on the noise value NOISE(PIC) of the whole input image and the per-macroblock noise value NOISE(MB) realizes appropriate denoising on a per macroblock basis depending on the noise level of the whole input image and the noise level per macroblock.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the setting circuit 22 increases the quantization value QP(MB) with increase in the noise value NOISE(MB) with the quantization value QP(PIC) being an upper limit.", "For a macroblock having a large noise value NOISE(MB), a large quantization value QP(MB) achieves high denoising effect by quantization.", "For a macroblock having a small noise value NOISE(MB), a small quantization value QP(MB) avoids image degradation due to quantization.", "Providing the upper limit at the quantization value QP(PIC) restricts the difference between the maximum and the minimum quantization value to a certain range, eliminating or reducing “floppiness”, and thus the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the setting circuit 23 sets the first correction value to the transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in the ideal image including no noise.", "Such first correction value realizes correction to bring the output image close to the ideal image, and thus improves image quality.", "In the image processor 1 according to the above embodiment, the setting circuit 24 (second correction value setting circuit) sets the per-macroblock scaling matrix SM(MB) (second correction value) for correction, on the basis of the first correction value and the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock second correction value based on the first correction value based on the image data D2 of the whole input image and the per-macroblock activity evaluation value ACT(MB) realizes appropriate correction on a per macroblock basis depending on the frequency component value of the whole input image and the attribute of a macroblock.", "In consequence, denoising effect per macroblock is improved and thus the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the setting circuit 24 holds multiple types of masks depending on the activity evaluation value ACT(MB), the masks containing arbitrary multipliers by frequency components, and performs masking on the first correction value using one of the masks corresponding to the activity evaluation value ACT(MB) calculated by the arithmetic circuit 20 to set the second correction value.", "In consequence, the second correction value depending on the per-macroblock activity evaluation value ACT(MB) is obtained simply and appropriately from the first correction value.", "In the image processor 1 according to the above embodiment, the setting circuit 24 sets the second correction value for a macroblock having a small activity evaluation value ACT(MB) to the first correction value for a low-frequency component, while setting the second correction value to substantially zero for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value ACT(MB) where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The setting circuit 24 sets the second correction value for a macroblock having a large activity evaluation value ACT(MB) to the first correction value for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value ACT(MB), masking not to cut off any frequency component realizes correction to sharpen the edge or texture portion, and thus improves image quality.", "The setting circuit 24 sets the second correction value for a macroblock having a medium activity evaluation value ACT(MB) to the first correction value for low- and middle-frequency components while setting the second correction value to substantially zero for a high-frequency component.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In the image processor 1 according to the above embodiment, the CPU 2 (determination circuit) determines whether denoising is to be performed on the basis of the noise value NOISE(PIC) of the whole input image and the activity evaluation value ACT(PIC) of the whole input image.", "Thus since denoising is performed on an input image that truly requires denoising while denoising on an input image that requires no denoising is avoided, power consumption is reduced.", "In the image processor 1 according to the above embodiment, the CPU 2 divides the noise value NOISE(PIC) of the whole input image by the activity evaluation value ACT(PIC) of the whole input image to calculate a noise strength.", "Then if the noise strength is lower than a predetermined threshold, denoising is determined to be unnecessary, while if the noise strength is higher than or equal to the threshold, denoising is determined to be necessary.", "Such determination by the CPU 2 achieves highly accurate identification of an input image that truly requires denoising.", "In the image processor 1 according to the above embodiment, the transform circuit 11, the quantization circuit 12, and the correction circuit 13 sequentially process partially-overlapping multiple macroblocks extracted from the input image.", "Partially overlapping macroblocks one another eliminates or reduces block noise.", "For a portion of the output image where multiple macroblocks overlap each other, an optimal value (average, in the above example) obtained from the overlapping macroblocks is output as image data of this portion of the image.", "Output of optimal value obtained from multiple macroblocks for overlapping portion realizes high denoising effect while avoiding image degradation.", "In the image processor 1 according to the above embodiment and second modification, the setting circuit 22 (quantization value setting circuit) sets the per-macroblock quantization value QP(MB) for quantization, on the basis of the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock quantization value QP(MB) based on the per-macroblock activity evaluation value ACT(MB) realizes appropriate denoising on a per macroblock basis depending on the attribute of a macroblock.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In the image processor 1 according to the above embodiment and second modification, the setting circuit 24 (correction value setting circuit) sets the per-macroblock scaling matrix SM(MB) (correction value) for correction, on the basis of the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock correction value based on the per-macroblock activity evaluation value ACT(MB) realizes appropriate correction on a per macroblock basis depending on the attribute of a macroblock.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the arithmetic circuit 20 calculates a sum of absolute difference between a smoothing value (weighted mean in the above example) of each pixel and an average smoothing value in a macroblock, and calculates an average of the sum of absolute difference in the macroblock to obtain a per-macroblock activity evaluation value ACT(MB).", "Thus the arithmetic circuit 20 appropriately obtains the activity evaluation value ACT(MB) on a per macroblock basis.", "In the image processor 1 according to the above embodiment, the setting circuit 22 sets the quantization value QP(MB) of a macroblock having a small activity evaluation value ACT(MB) to a large value.", "In a flat portion having a small activity evaluation value ACT(MB) where noise is noticeable, a large quantization value QP(MB) achieves high denoising effect by quantization.", "The setting circuit 22 sets the quantization value QP(MB) of a macroblock having a large activity evaluation value ACT(MB) to a small value.", "In an edge or texture portion having a large activity evaluation value ACT(MB), a small quantization value QP(MB) prevents the edge or texture portion from blurring due to quantization, and thus improves image quality.", "The setting circuit 22 sets the quantization value QP(MB) of a macroblock having a medium activity evaluation value ACT(MB) to a medium value.", "In an image portion other than flat, edge, and texture portions, a medium quantization value QP(MB) avoids excessive or insufficient denoising effect on the image portion.", "In the image processor 1 according to the above embodiment, the setting circuit 22 sets the per-macroblock quantization value QP(MB) for quantization, on the basis of the per-macroblock noise value NOISE(MB).", "The per-macroblock quantization value QP(MB) based on the per-macroblock noise value NOISE(MB) realizes appropriate denoising on a per macroblock basis depending on the noise level per macroblock.", "In consequence, since decrease in resolution is effectively avoided, the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "In the image processor 1 according to the above embodiment, the setting circuit 24 sets the per-macroblock correction value for correction, on the basis of the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock correction value based on the per-macroblock activity evaluation value ACT(MB) realizes appropriate correction on a per macroblock basis depending on the attribute of a macroblock.", "In consequence, denoising effect per macroblock is improved and thus the image quality is improved as a whole.", "In the image processor 1 according to the above embodiment, the setting circuit 22 increases the quantization value QP(MB) with increase in a noise value.", "For a macroblock having a large noise value, a large quantization value QP(MB) achieves high denoising effect by quantization.", "For a macroblock having a small noise value, a small quantization value QP(MB) avoids image degradation due to quantization.", "In the image processor 1 according to the above embodiment, the setting circuit 24 holds multiple types of masks depending on the activity evaluation value ACT(MB), the masks containing arbitrary multipliers by frequency components, and sets the correction value to the multiplier for one of the masks corresponding to the activity evaluation value ACT(MB) calculated by the arithmetic circuit 20.In consequence, the correction value depending on the per-macroblock activity evaluation value ACT(MB) is obtained simply and appropriately.", "In the image processor 1 according to the above embodiment, the setting circuit 24 sets the correction value for a macroblock having a small activity evaluation value ACT(MB) to one time for a low-frequency component, while setting the correction value to substantially zero time for middle- and high-frequency components.", "In a flat portion having a small activity evaluation value ACT(MB) where noise is noticeable, masking to cut off middle- and high-frequency components achieves high denoising effect by correction.", "The setting circuit 24 sets the correction value for a macroblock having a large activity evaluation value ACT(MB) to one time for low-, middle-, and high-frequency components.", "In an edge or texture portion having a large activity evaluation value ACT(MB), masking not to cut off any frequency component realizes correction to sharpen the edge or texture portions, and thus improves image quality.", "The setting circuit 24 set the correction value for a macroblock having a medium activity evaluation value ACT(MB) to one time for low- and middle-frequency components, while setting the correction value to substantially zero time for high-frequency components.", "In an image portion other than flat, edge, and texture portions, masking to cut off only a high-frequency component achieves moderate denoising effect by correction.", "In the image processor 1 according to the above embodiment, the setting circuit 23 (first correction value setting circuit) sets the scaling matrix SM(PIC) (first correction value) per input image on the basis of the image data D2 (second image data) of the whole input image, and the correction circuit 13 performs correction per frequency component on the image data D3 (third image data) to generate the image data D4 (fourth image data).", "Correction per frequency component using the first correction value based on the image data D2 of the whole input image realizes appropriate denoising depending on a noise level per frequency component.", "In consequence, high denoising effect is realized while image degradation is avoided.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "the setting circuit 23 sets the first correction value to the transform value for transforming each frequency component value in the input image so that a ratio among frequency component values in the input image equals to that in the ideal image including no noise.", "Such first correction value realizes correction to bring the output image close to the ideal image, and thus improves image quality.", "In the image processor 1 according to the above embodiment, the setting circuit 24 (correction value setting circuit) sets the per-macroblock scaling matrix SM(MB) (correction value) for correction, on the basis of the per-macroblock activity evaluation value ACT(MB).", "The per-macroblock correction value based on the per-macroblock activity evaluation value ACT(MB) realizes appropriate correction on a per macroblock basis depending on the attribute of a macroblock.", "In consequence, denoising effect per block is improved and thus the image quality is improved as a whole.", "In comparison with applying a spatial filter multiple times in an effort to improve denoising effect, processing time is reduced, and with no need for a temporal memory for storing intermediate values, circuit size is also reduced.", "The setting circuit 24 holds multiple types of masks depending on the activity evaluation value ACT(MB), the masks containing arbitrary multipliers by frequency components, and sets the correction value to the multiplier for one of the masks corresponding to the activity evaluation value ACT(MB) calculated by the arithmetic circuit 20.In consequence the correction value depending on the per-macroblock activity evaluation value ACT(MB) is obtained simply and appropriately.", "While the invention has been described in detail, the foregoing description is in all aspects illustrative and not restrictive.", "It is understood that numerous other modifications and variations can be devised without departing from the scope of the invention." ] ]
Patent_15874346
[ [ "VIDEO CODING AND DECODING METHODS AND VIDEO CODING AND DECODING DEVICES USING ADAPTIVE LOOP FILTERING", "A method of decoding video, the method including receiving and parsing a bitstream which includes encoded video; extracting encoded image data relating to a current picture, which image data is assigned to at least one maximum coding unit, information relating to a coded depth and an encoding mode for each of the at least one maximum coding unit, and filter coefficient information for performing loop filtering on the current picture, from the bitstream; decoding the encoded image data in units of the at least one maximum coding unit, based on the information relating to the coded depth and the encoding mode for each of the at least one maximum coding unit; and performing deblocking on the decoded image data relating to the current picture, and performing loop filtering on the deblocked data, based on continuous one-dimensional (1D) filtering." ], [ "1.A method for decoding video, the method comprising: obtaining a size information of a maximum coding unit and information whether loop filtering for compensating pixel value is to be performed, from a bitstream; determining the maximum coding unit by splitting a picture, based on the size information of the maximum coding unit; reconstructing encoded image data of the maximum coding unit; determining a direction of an edge of the reconstructed image data of the maximum coding unit; and performing the loop filtering on deblocking filtered data of the reconstructed image data of the maximum coding unit, based on the information of whether loop filtering is to be performed, wherein the loop filtering is performed according to the direction of the edge, wherein a coding unit among at least one coding unit in the maximum coding unit includes at least one prediction unit to perform prediction on the coding unit, and wherein the coding unit is split into at least one transformation unit independently from the at least one prediction unit.", "2.A method for encoding video, the method comprising: determining a maximum coding unit by splitting a picture; generating size information of the maximum coding unit; determining at least one prediction unit in a coding unit among at least one coding unit in the maximum coding unit; determining at least one transformation unit in the coding unit independently from the at least one prediction unit; generating reconstructed data of the maximum coding unit by using prediction data generated by performing prediction on a prediction unit among the at least one prediction unit and residual data generated by performing inverse-transformation on a transformation unit among the at least one transformation unit; performing a loop filtering on deblocking filtered data of the reconstructed data in order to compensate pixel values of the maximum coding unit; and generating information indicating whether the loop filtering is performed on the deblocking filtered data.", "3.An apparatus for encoding video, the apparatus comprising: an encoder configured to: determine a maximum coding unit by splitting a picture; generate size information of the maximum coding unit; determine at least one prediction unit in a coding unit among at least one coding unit in the maximum coding unit; determine at least one transformation unit in the coding unit independently from the at least one prediction unit; and generate reconstructed data of the maximum coding unit by using prediction data generated by performing prediction on a prediction unit among the at least one prediction unit and residual data generated by performing inverse-transformation on a transformation unit among the at least one transformation unit, and a loop filtering unit configured to: perform a loop filtering on deblocking filtered data of the reconstructed data in order to compensate pixel values of the maximum coding unit; and generate information indicating whether the loop filtering is performed on the deblocking filtered data.", "4.A method for encoding video, the method comprising: determining a maximum coding unit by splitting a picture; generating size information of the maximum coding unit; determining at least one prediction unit in a coding unit among at least one coding unit in the maximum coding unit; determining at least one transformation unit in the coding unit independently from the at least one prediction unit; generating reconstructed data of the maximum coding unit by using prediction data generated by performing prediction on a prediction unit among the at least one prediction unit and residual data generated by performing inverse-transformation on a transformation unit among the at least one transformation unit; determining a direction of an edge of the reconstructed data of the maximum coding unit; and performing a loop filtering on deblocking filtered data of the reconstructed data in order to compensate pixel values of the maximum coding unit, wherein the loop filtering is performed according to the direction of the edge.", "5.An apparatus for encoding video, the apparatus comprising: an encoder configured to: determine a maximum coding unit by splitting a picture; generate size information of the maximum coding unit; determine at least one prediction unit in a coding unit among at least one coding unit in the maximum coding unit; determine at least one transformation unit in the coding unit independently from the at least one prediction unit; and generate reconstructed data of the maximum coding unit by using prediction data generated by performing prediction on a prediction unit among the at least one prediction unit and residual data generated by performing inverse-transformation on a transformation unit among the at least one transformation unit, and a loop filtering unit configured to: determine a direction of an edge of the reconstructed data of the maximum coding unit; and perform a loop filtering on deblocking filtered data of the reconstructed data in order to compensate pixel values of the maximum coding unit, wherein the loop filtering is performed according to the direction of the edge.", "6.A method for encoding video, the method comprising: determining a maximum coding unit by splitting a picture; generating size information of the maximum coding unit; determining at least one prediction unit in a coding unit among at least one coding unit in the maximum coding unit; determining at least one transformation unit in the coding unit independently from the at least one prediction unit; generating reconstructed data of the maximum coding unit by using prediction data generated by performing prediction on a prediction unit among the at least one prediction unit and residual data generated by performing inverse-transformation on a transformation unit among the at least one transformation unit; determining a direction of an edge of the reconstructed data of the maximum coding unit; performing a loop filtering on deblocking filtered data of the reconstructed data in order to compensate pixel values of the maximum coding unit, wherein the loop filtering is performed according to the direction of the edge; and generating information indicating whether the loop filtering is performed on the deblocking filtered data.", "7.A non-transitory computer-readable medium for recording a bitstream, the bitstream comprising: size information of a maximum coding unit split from a picture; information indicating whether a loop filtering is performed on deblocking filtered data of reconstructed data of the maximum coding unit; and encoded data generated based on compensated pixel values of the maximum coding unit, wherein the compensated pixel values of the maximum coding unit are generated by: determining at least one prediction unit in a coding unit among at least one coding unit in the maximum coding unit; determining at least one transformation unit in the coding unit independently from the at least one prediction unit; generating reconstructed data of the maximum coding unit by using prediction data generated by performing prediction on a prediction unit among the at least one prediction unit and residual data generated by performing inverse-transformation on a transformation unit among the at least one transformation unit; and performing the loop filtering on the deblocking filtered data of the reconstructed data in order to compensate pixel values of the maximum coding unit.", "8.A non-transitory computer-readable medium for recording a bitstream, the bitstream comprising: size information of a maximum coding unit split from a picture; and encoded data generated based on compensated pixel values of the maximum coding unit, wherein the compensated pixel values of the maximum coding unit are generated by: determining at least one prediction unit in a coding unit among at least one coding unit in the maximum coding unit; determining at least one transformation unit in the coding unit independently from the at least one prediction unit; generating reconstructed data of the maximum coding unit by using prediction data generated by performing prediction on a prediction unit among the at least one prediction unit and residual data generated by performing inverse-transformation on a transformation unit among the at least one transformation unit; determining a direction of an edge of the reconstructed data of the maximum coding unit; and performing a loop filtering on deblocking filtered data of the reconstructed data in order to compensate pixel values of the maximum coding unit, wherein the loop filtering is performed according to the direction of the edge.", "9.A non-transitory computer-readable medium for recording a bitstream, the bitstream comprising: size information of a maximum coding unit split from a picture; information indicating whether a loop filtering is performed on deblocking filtered data of reconstructed data of the maximum coding unit; and encoded data generated based on compensated pixel values of the maximum coding unit, wherein the compensated pixel values of the maximum coding unit are generated by: determining at least one prediction unit in a coding unit among at least one coding unit in the maximum coding unit; determining at least one transformation unit in the coding unit independently from the at least one prediction unit; generating reconstructed data of the maximum coding unit by using prediction data generated by performing prediction on a prediction unit among the at least one prediction unit and residual data generated by performing inverse-transformation on a transformation unit among the at least one transformation unit; determining a direction of an edge of the reconstructed data of the maximum coding unit; and performing the loop filtering on the deblocking filtered data of the reconstructed data in order to compensate pixel values of the maximum coding unit, wherein the loop filtering is performed according to the direction of the edge.", "10.A non-transitory computer-readable medium for recording a bitstream, the bitstream comprising: size information of a maximum coding unit split from a picture; split information indicating whether the maximum coding unit is split into at least one coding unit; information indicating whether a loop filtering is performed on deblocking filtered data of reconstructed data of the maximum coding unit; and encoded data generated based on compensated pixel values of the maximum coding unit, wherein the compensated pixel values of the maximum coding unit are generated by: determining at least one prediction unit in a coding unit among the at least one coding unit in the maximum coding unit; determining at least one transformation unit in the coding unit independently from the at least one prediction unit; generating reconstructed data of the maximum coding unit by using prediction data generated by performing prediction on a prediction unit among the at least one prediction unit and residual data generated by performing inverse-transformation on a transformation unit among the at least one transformation unit; and performing the loop filtering on the deblocking filtered data of the reconstructed data in order to compensate pixel values of the maximum coding unit.", "11.A non-transitory computer-readable medium for recording a bitstream, the bitstream comprising: size information of a maximum coding unit split from a picture; split information indicating whether the maximum coding unit is split into at least one coding unit; and encoded data generated based on compensated pixel values of the maximum coding unit, wherein the compensated pixel values of the maximum coding unit are generated by: determining at least one prediction unit in a coding unit among the at least one coding unit in the maximum coding unit; determining at least one transformation unit in the coding unit independently from the at least one prediction unit; generating reconstructed data of the maximum coding unit by using prediction data generated by performing prediction on a prediction unit among the at least one prediction unit and residual data generated by performing inverse-transformation on a transformation unit among the at least one transformation unit; determining a direction of an edge of the reconstructed data of the maximum coding unit; and performing a loop filtering on deblocking filtered data of the reconstructed data in order to compensate pixel values of the maximum coding unit, wherein the loop filtering is performed according to the direction of the edge." ], [ "<SOH> BACKGROUND ART <EOH>As hardware for reproducing and storing high resolution video content or high quality video content is being developed and supplied, a need for a video coder/decoder (“codec”) for effectively encoding or decoding the high resolution video content or high quality video content is increasing.", "In a conventional video codec, video is encoded according to a limited encoding method, based on a macroblock having a predetermined size.", "In addition, the conventional video codec uses loop filtering to improve the quality of reproduced image data." ], [ "<SOH> SUMMARY <EOH>Apparatuses and methods consistent with exemplary embodiments relate to encoding and decoding of video, according to adaptive loop filtering performed by using continuous one-dimensional (1D) filtering.", "According to one aspect of one or more exemplary embodiments, there is provided a method of decoding video.", "The method includes: receiving and parsing a bitstream which includes encoded video; extracting encoded image data relating to a current picture, which encoded data is assigned to at least one maximum coding unit, information relating to a coded depth and an encoding mode for each of the at least one maximum coding unit, and filter coefficient information for performing loop filtering on the current picture, from the bitstream; decoding the encoded image data in units of the at least one maximum coding unit, based on the information relating to the coded depth and the encoding mode for each of the at least one maximum coding unit; and performing deblocking on the decoded image data relating to the current picture, and performing loop filtering on the deblocked data, by using continuous one-dimensional (1D) filtering.", "According to one aspect of one or more exemplary embodiments, there is provided a method for decoding video.", "The method includes: receiving and parsing a bitstream which includes encoded video; extracting encoded image data relating to a current picture, which encoded data is assigned to at least one maximum coding unit, information relating to a coded depth and an encoding mode for each of the at least one maximum coding unit, and filter coefficient information for performing loop filtering on the current picture, from the bitstream; decoding the encoded image data in units of the at least one maximum coding unit, based on the information relating to the coded depth and the encoding mode for each of the at least one maximum coding unit; and performing deblocking on the decoded image data relating to the current picture, and performing loop filtering on the deblocked data by using continuous one-dimensional (1D) filtering.", "The coding unit may be characterized by a maximum size and a depth.", "The depth denotes the number of times a coding unit is hierarchically split, and as the depth increases, deeper coding units according to depths may be split from the maximum coding unit to obtain minimum coding units.", "The depth is increased from an upper depth to a lower depth.", "As the depth increases, the number of times that the maximum coding unit is split increases, and a total number of possible times that the maximum coding unit may be split corresponds to a maximum depth.", "The maximum size and the maximum depth of the coding unit may be predetermined.", "The extracting of the encoded image data, the information relating to the coded depth and the encoding mode, and the filter coefficient information may include extracting residual information relating to respective differences between corresponding pairs of continuous filter coefficients of each of a plurality of 1D filters.", "The performing of the loop filtering may include successively performing 1D filtering in a horizontal direction and then in a vertical direction to restore the current picture.", "The performing of the loop filtering may include deriving a filter coefficient of each of the plurality of 1D filters, based on the residual information; and performing the successive 1D filtering by using the derived filter coefficient of each of the plurality of 1D filters.", "The deriving of the filter coefficient of each of the plurality of 1D filters may include calculating a current filter coefficient of a respective one of the plurality of 1D filters by adding a respective difference between the current filter coefficient and a corresponding previous filter coefficient of the respective one of the plurality of 1D filters to the corresponding previous filter coefficient.", "The performing of the loop filtering may include filtering nine pieces of continuous data arranged in a horizontal direction from among the deblocked data by using five horizontal 1D filter coefficients; and filtering nine pieces of continuous data arranged in a vertical direction from among the deblocked data by using five vertical 1D filter coefficients.", "According to another aspect of one or more exemplary embodiments, there is provided a method for encoding video.", "The method includes: assigning at least one region of a current picture into at least one maximum coding unit; determining a coded depth at which to output a final encoding result according to at least one split region, which is divided from one of the at least one region of the at least one maximum coding unit, by encoding the at least one split region according to depths, wherein each of the depths is proportional to a number of times that the one of the at least one region of the at least one maximum coding unit is split; and encoding and outputting image data, which is a final result of encoding the at least one split region, encoding information relating to the coded depth and a prediction mode, and encoding filter coefficient information relating to loop filtering performed by using continuous one-dimensional (1D) filtering after deblocking is performed during encoding of the current picture, in units of the at least one maximum coding unit.", "The outputting of the filter coefficient information relating to the loop filtering may include encoding a respective difference between a current filter coefficient of a respective one of the plurality of 1D filters and a previous filter coefficient of the respective one of the plurality of 1D filters as the residual information for each of the plurality of 1D filters.", "The at least one maximum coding unit may include a coding unit which corresponds to a respective one of the depths, each of which is obtained by hierarchically splitting the at least one maximum coding unit according to at least one depth.", "Each coding unit corresponding to an upper depth may include a plurality of coding units which correspond to respective lower depths.", "The coded depth may be a depth having the least encoding error from among at least one coded depth that is hierarchically split from the at least one maximum coding unit.", "According to another aspect of one or more exemplary embodiments, there is provided an apparatus for decoding video.", "The apparatus includes: a receiver which receives and parses a bitstream which includes encoded video; an extractor which extracts encoded image data relating to a current picture, which image data is assigned to at least one maximum coding unit, information relating to a coded depth and an encoding mode for each of the at least one maximum coding unit, and filter coefficient information for performing loop filtering on the current picture, from the bitstream; an image data decoder which decodes the encoded image data in units of the at least one maximum coding unit, based on the information relating to the coded depth and the encoding mode for each of the at least one maximum coding unit; and a loop filtering performing unit which performs deblocking on the decoded image data relating to the current picture, and which performs loop filtering on the deblocked data by using continuous one-dimensional (1D) filtering.", "According to another aspect of one or more exemplary embodiments, there is provided an apparatus for encoding video.", "The apparatus includes: a maximum coding unit splitter which assigns at least one region of a current picture into at least one maximum coding unit; a coded depth determiner which determines a coded depth at which to output a final encoding result according to at least one split region, which is divided from the at least one region of the at least one maximum coding unit, by encoding the at least one split region according to depths, wherein each of the depths is proportional to a number of times a region of the at least one maximum coding unit is split; and an output unit which encodes and outputs image data, which is a final result of encoding the at least one split region, encoding information relating to the coded depth and a prediction mode, and filter coefficient information relating to loop filtering performed by using continuous one-dimensional (1D) filtering after deblocking is performed during encoding of the current picture, in units of the at least one maximum coding unit.", "According to another aspect of one or more exemplary embodiments, there is provided a non-transitory computer readable recording medium having recorded thereon a computer program for executing the method for encoding video.", "According to another aspect of one or more exemplary embodiments, there is provided a non-transitory computer readable recording medium having recorded thereon a computer program for executing the method for decoding video." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This is a continuation of U.S. application Ser.", "No.", "15/491,112, filed Apr.", "19, 2017, which is a continuation of U.S. application Ser.", "No.", "15/293,945, filed Oct. 14, 2016, which is a continuation of U.S. application Ser.", "No.", "15/133,844, filed Apr.", "20, 2016, which is a continuation of U.S. application Ser.", "No.", "13/390,350, filed Feb. 14, 2012, which is a national stage entry of International Patent Application No.", "PCT/KR2010/005284, filed on Aug. 12, 2010, which claims priority from Korean Patent Application No.", "10-2009-0075336, filed on Aug. 14, 2009, in the Korean Intellectual Property Office, the disclosures of which are incorporated by reference in their entireties.", "FIELD Apparatuses and methods consistent with exemplary embodiments relate to encoding and decoding video.", "BACKGROUND ART As hardware for reproducing and storing high resolution video content or high quality video content is being developed and supplied, a need for a video coder/decoder (“codec”) for effectively encoding or decoding the high resolution video content or high quality video content is increasing.", "In a conventional video codec, video is encoded according to a limited encoding method, based on a macroblock having a predetermined size.", "In addition, the conventional video codec uses loop filtering to improve the quality of reproduced image data.", "SUMMARY Apparatuses and methods consistent with exemplary embodiments relate to encoding and decoding of video, according to adaptive loop filtering performed by using continuous one-dimensional (1D) filtering.", "According to one aspect of one or more exemplary embodiments, there is provided a method of decoding video.", "The method includes: receiving and parsing a bitstream which includes encoded video; extracting encoded image data relating to a current picture, which encoded data is assigned to at least one maximum coding unit, information relating to a coded depth and an encoding mode for each of the at least one maximum coding unit, and filter coefficient information for performing loop filtering on the current picture, from the bitstream; decoding the encoded image data in units of the at least one maximum coding unit, based on the information relating to the coded depth and the encoding mode for each of the at least one maximum coding unit; and performing deblocking on the decoded image data relating to the current picture, and performing loop filtering on the deblocked data, by using continuous one-dimensional (1D) filtering.", "According to one aspect of one or more exemplary embodiments, there is provided a method for decoding video.", "The method includes: receiving and parsing a bitstream which includes encoded video; extracting encoded image data relating to a current picture, which encoded data is assigned to at least one maximum coding unit, information relating to a coded depth and an encoding mode for each of the at least one maximum coding unit, and filter coefficient information for performing loop filtering on the current picture, from the bitstream; decoding the encoded image data in units of the at least one maximum coding unit, based on the information relating to the coded depth and the encoding mode for each of the at least one maximum coding unit; and performing deblocking on the decoded image data relating to the current picture, and performing loop filtering on the deblocked data by using continuous one-dimensional (1D) filtering.", "The coding unit may be characterized by a maximum size and a depth.", "The depth denotes the number of times a coding unit is hierarchically split, and as the depth increases, deeper coding units according to depths may be split from the maximum coding unit to obtain minimum coding units.", "The depth is increased from an upper depth to a lower depth.", "As the depth increases, the number of times that the maximum coding unit is split increases, and a total number of possible times that the maximum coding unit may be split corresponds to a maximum depth.", "The maximum size and the maximum depth of the coding unit may be predetermined.", "The extracting of the encoded image data, the information relating to the coded depth and the encoding mode, and the filter coefficient information may include extracting residual information relating to respective differences between corresponding pairs of continuous filter coefficients of each of a plurality of 1D filters.", "The performing of the loop filtering may include successively performing 1D filtering in a horizontal direction and then in a vertical direction to restore the current picture.", "The performing of the loop filtering may include deriving a filter coefficient of each of the plurality of 1D filters, based on the residual information; and performing the successive 1D filtering by using the derived filter coefficient of each of the plurality of 1D filters.", "The deriving of the filter coefficient of each of the plurality of 1D filters may include calculating a current filter coefficient of a respective one of the plurality of 1D filters by adding a respective difference between the current filter coefficient and a corresponding previous filter coefficient of the respective one of the plurality of 1D filters to the corresponding previous filter coefficient.", "The performing of the loop filtering may include filtering nine pieces of continuous data arranged in a horizontal direction from among the deblocked data by using five horizontal 1D filter coefficients; and filtering nine pieces of continuous data arranged in a vertical direction from among the deblocked data by using five vertical 1D filter coefficients.", "According to another aspect of one or more exemplary embodiments, there is provided a method for encoding video.", "The method includes: assigning at least one region of a current picture into at least one maximum coding unit; determining a coded depth at which to output a final encoding result according to at least one split region, which is divided from one of the at least one region of the at least one maximum coding unit, by encoding the at least one split region according to depths, wherein each of the depths is proportional to a number of times that the one of the at least one region of the at least one maximum coding unit is split; and encoding and outputting image data, which is a final result of encoding the at least one split region, encoding information relating to the coded depth and a prediction mode, and encoding filter coefficient information relating to loop filtering performed by using continuous one-dimensional (1D) filtering after deblocking is performed during encoding of the current picture, in units of the at least one maximum coding unit.", "The outputting of the filter coefficient information relating to the loop filtering may include encoding a respective difference between a current filter coefficient of a respective one of the plurality of 1D filters and a previous filter coefficient of the respective one of the plurality of 1D filters as the residual information for each of the plurality of 1D filters.", "The at least one maximum coding unit may include a coding unit which corresponds to a respective one of the depths, each of which is obtained by hierarchically splitting the at least one maximum coding unit according to at least one depth.", "Each coding unit corresponding to an upper depth may include a plurality of coding units which correspond to respective lower depths.", "The coded depth may be a depth having the least encoding error from among at least one coded depth that is hierarchically split from the at least one maximum coding unit.", "According to another aspect of one or more exemplary embodiments, there is provided an apparatus for decoding video.", "The apparatus includes: a receiver which receives and parses a bitstream which includes encoded video; an extractor which extracts encoded image data relating to a current picture, which image data is assigned to at least one maximum coding unit, information relating to a coded depth and an encoding mode for each of the at least one maximum coding unit, and filter coefficient information for performing loop filtering on the current picture, from the bitstream; an image data decoder which decodes the encoded image data in units of the at least one maximum coding unit, based on the information relating to the coded depth and the encoding mode for each of the at least one maximum coding unit; and a loop filtering performing unit which performs deblocking on the decoded image data relating to the current picture, and which performs loop filtering on the deblocked data by using continuous one-dimensional (1D) filtering.", "According to another aspect of one or more exemplary embodiments, there is provided an apparatus for encoding video.", "The apparatus includes: a maximum coding unit splitter which assigns at least one region of a current picture into at least one maximum coding unit; a coded depth determiner which determines a coded depth at which to output a final encoding result according to at least one split region, which is divided from the at least one region of the at least one maximum coding unit, by encoding the at least one split region according to depths, wherein each of the depths is proportional to a number of times a region of the at least one maximum coding unit is split; and an output unit which encodes and outputs image data, which is a final result of encoding the at least one split region, encoding information relating to the coded depth and a prediction mode, and filter coefficient information relating to loop filtering performed by using continuous one-dimensional (1D) filtering after deblocking is performed during encoding of the current picture, in units of the at least one maximum coding unit.", "According to another aspect of one or more exemplary embodiments, there is provided a non-transitory computer readable recording medium having recorded thereon a computer program for executing the method for encoding video.", "According to another aspect of one or more exemplary embodiments, there is provided a non-transitory computer readable recording medium having recorded thereon a computer program for executing the method for decoding video.", "BRIEF DESCRIPTION OF DRAWINGS FIG.", "1 is a block diagram of a video encoding apparatus, according to an exemplary embodiment.", "FIG.", "2 is a block diagram of a video decoding apparatus, according to an exemplary embodiment.", "FIG.", "3 is a diagram which illustrates a concept of coding units according to an exemplary embodiment.", "FIG.", "4 is a block diagram of an image encoder based on coding units according to an exemplary embodiment.", "FIG.", "5 is a block diagram of an image decoder based on coding units according to an exemplary embodiment.", "FIG.", "6 is a diagram which illustrates deeper coding units according to depths and partitions, according to an exemplary embodiment.", "FIG.", "7 is a diagram which illustrates a relationship between a coding unit and transformation units, according to an exemplary embodiment.", "FIG.", "8 is a diagram which illustrates encoding information relating to coding units corresponding to a coded depth, according to an exemplary embodiment.", "FIG.", "9 is a diagram which illustrates deeper coding units according to depths, according to an exemplary embodiment.", "FIGS.", "10, 11, and 12 are diagrams which illustrate a relationship between coding units, prediction units, and transformation units, according to an exemplary embodiment.", "FIG.", "13 is a diagram which illustrates a relationship between a coding unit, a prediction unit or a partition, and a transformation unit, based on encoding mode information provided in Table 1, according to an exemplary embodiment.", "FIG.", "14 is a flowchart which illustrates a method for encoding video, according to an exemplary embodiment.", "FIG.", "15 is a flowchart which illustrates a method for decoding video, according to an exemplary embodiment.", "FIG.", "16 is a block diagram of a video encoding apparatus which uses loop filtering performed by using continuous one-dimensional (1D) filtering, according to an exemplary embodiment.", "FIG.", "17 is a block diagram of a video decoding apparatus using loop filtering performed by using the continuous 1D filtering, according to an exemplary embodiment.", "FIG.", "18 is a flowchart which illustrates a method for performing the continuous 1D filtering, according to an exemplary embodiment.", "FIG.", "19 is a flowchart which illustrates a method for performing the continuous 1D filtering, according to another exemplary embodiment.", "FIG.", "20 is a flowchart which illustrates a method for encoding video by performing loop filtering by using the continuous 1D filtering, according to an exemplary embodiment.", "FIG.", "21 is a flowchart which illustrates a method for decoding video by performing loop filtering by using the continuous 1D filtering, according to an exemplary embodiment.", "DETAILED DESCRIPTION OF THE EXEMPLARY EMBODIMENTS Hereinafter, a method and apparatus for encoding video and a method and apparatus for decoding video according to exemplary embodiments will be described more fully with reference to the accompanying drawings.", "Specifically, encoding and decoding of video, which is performed based on spatially hierarchical data units, according to exemplary embodiments, will be described with reference to FIGS.", "1 to 15 below.", "Encoding and decoding of video, which is performed based on spatially hierarchical data units and by using adaptive loop filtering, will be described with reference to FIGS.", "16 to 21 below.", "In the present specification, an “image” should be understood as an inclusive term that may denote not only a still image but also a moving image, such as, for example, video.", "A method and apparatus for encoding video and a method and apparatus for decoding video according to exemplary embodiments will now be described with reference to FIGS.", "1 to 15.FIG.", "1 is a block diagram of a video encoding apparatus 100, according to an exemplary embodiment.", "The video encoding apparatus 100 includes a maximum coding unit splitter 110, a coding unit determiner 120, and an output unit 130.The maximum coding unit splitter 110 may split a current picture based on a maximum coding unit for the current picture of an image.", "If the current picture is larger than the maximum coding unit, image data included in the current picture may be split into the at least one maximum coding unit.", "The maximum coding unit according to an exemplary embodiment may be, for example, a data unit having a size of 32×32, 64×64, 128×128, 256×256, such that a shape of the data unit is a square having a width and height which are equal to a power of two.", "The image data may be output to the coding unit determiner 120 according to the at least one maximum coding unit.", "A coding unit according to an exemplary embodiment may be characterized by a maximum size and a depth.", "The depth denotes a number of times the coding unit is spatially split from the maximum coding unit, and as the depth deepens or increases, deeper coding units according to depths may be split from the maximum coding unit to a minimum coding unit.", "A depth of the maximum coding unit is an uppermost depth, and a depth of the minimum coding unit is a lowermost depth.", "Because a size of a coding unit corresponding to each depth decreases as the depth of the maximum coding unit increases, a coding unit corresponding to an upper depth may include a plurality of coding units corresponding to lower depths.", "As described above, the image data relating to the current picture is split into the maximum coding units according to a maximum size of the coding unit, and each of the maximum coding units may include deeper coding units that are split according to depths.", "Because the maximum coding unit according to an exemplary embodiment is split according to depths, the image data of a spatial domain included in the maximum coding unit may be hierarchically classified according to depths.", "A maximum depth and a maximum size of a coding unit, which limit the total number of times a height and a width of the maximum coding unit are hierarchically split, may be predetermined.", "The coding unit determiner 120 encodes at least one split region obtained by splitting a region of the maximum coding unit according to depths, and determines a depth at which to output a finally encoded image data according to the at least one split region.", "In particular, the coding unit determiner 120 determines a coded depth by encoding the image data in the deeper coding units according to depths, according to the maximum coding unit of the current picture, and selecting a depth having the least encoding error.", "Thus, the encoded image data of the coding unit corresponding to the determined coded depth is finally outputted.", "In addition, the coding units corresponding to the coded depth may be regarded as encoded coding units.", "The determined coded depth and the encoded image data according to the determined coded depth are outputted to the output unit 130.The image data in the maximum coding unit is encoded based on the deeper coding units corresponding to at least one depth equal to or below the maximum depth, and results of encoding the image data are compared based on each of the deeper coding units.", "A depth having the least encoding error may be selected after comparing encoding errors of the deeper coding units.", "At least one coded depth may be selected for each maximum coding unit.", "The size of the maximum coding unit is split in a similar manner as a coding unit is hierarchically split according to depths, and as the number of coding units increases.", "In addition, even if coding units correspond to the same depth in one maximum coding unit, it is determined whether to split each of the coding units corresponding to the same depth to a lower depth by separately measuring an encoding error of the image data of the each coding unit.", "Accordingly, even when image data is included in one maximum coding unit, the image data is split to regions according to the depths and the encoding errors may differ according to regions in the one maximum coding unit, and thus the coded depths may differ according to regions in the image data.", "Thus, one or more coded depths may be determined in one maximum coding unit, and the image data of the maximum coding unit may be divided according to coding units of at least one coded depth.", "Accordingly, the coding unit determiner 120 may determine coding units having a tree structure included in the maximum coding unit.", "The “coding units having a tree structure” according to an exemplary embodiment include coding units corresponding to a depth determined to be the coded depth, from among all deeper coding units included in the maximum coding unit.", "A coding unit of a coded depth may be hierarchically determined according to depths in the same region of the maximum coding unit, and may be independently determined in different regions.", "Similarly, a coded depth in a current region may be independently determined from a coded depth in another region.", "A maximum depth, according to an exemplary embodiment, is an index related to the number of splitting times from a maximum coding unit to a minimum coding unit.", "A first maximum depth, according to an exemplary embodiment, may denote the total number of splitting times from the maximum coding unit to the minimum coding unit.", "A second maximum depth, according to an exemplary embodiment, may denote the total number of depth levels from the maximum coding unit to the minimum coding unit.", "For example, when a depth of the maximum coding unit is 0, a depth of a coding unit in which the maximum coding unit is split once may be set to 1, and a depth of a coding unit in which the maximum coding unit is split twice may be set to 2.In particular, if the minimum coding unit is a coding unit in which the maximum coding unit is split four times, five depth levels of depths 0, 1, 2, 3 and 4 exist, and thus the first maximum depth may be set to 4, and the second maximum depth may be set to 5.Prediction encoding and transformation may be performed according to the maximum coding unit.", "The prediction encoding and the transformation may also be performed based on the deeper coding units according to a depth equal to or depths less than the maximum depth, according to the maximum coding unit.", "Because the number of deeper coding units increases whenever the maximum coding unit is split according to depths, encoding including the prediction encoding and the transformation may be performed on all of the deeper coding units generated as the depth increases.", "For convenience of description, the prediction encoding and the transformation will now be described based on a coding unit of a current depth, in a maximum coding unit.", "The video encoding apparatus 100 may variably select a size or shape of a data unit for encoding the image data.", "In order to encode the image data, operations, such as prediction encoding, transformation, and entropy encoding, are performed, and the same data unit may be used for all operations, or different data units may be used for each operation.", "For example, the video encoding apparatus 100 may select not only a coding unit for encoding the image data, but also a data unit different from the coding unit so as to perform the prediction encoding on the image data in the coding unit.", "In order to perform prediction encoding in the maximum coding unit, the prediction encoding may be performed based on a coding unit corresponding to a coded depth, i.e., based on a coding unit that is no longer split to coding units corresponding to a lower depth.", "Hereinafter, the coding unit that is no longer split and becomes a basis unit for prediction encoding will be referred to as a “prediction unit.” A partition obtained by splitting the prediction unit may include a prediction unit or a data unit obtained by splitting at least one of a height and a width of the prediction unit.", "For example, when a coding unit of 2N×2N (where N is a positive integer) is no longer split and becomes a prediction unit of 2N×2N, a size of a partition may be equal to, for example, 2N×2N, 2N×N, N×2N, or N×N.", "Examples of a partition type include symmetrical partitions that are obtained by symmetrically splitting a height or width of the prediction unit, partitions obtained by asymmetrically splitting the height or width of the prediction unit, such as 1:n or n:1, partitions that are obtained by geometrically splitting the prediction unit, and partitions having arbitrary shapes.", "A prediction mode of the prediction unit may be at least one of an intra mode, a inter mode, and a skip mode.", "For example, the intra mode or the inter mode may be performed on the partition of 2N×2N, 2N×N, N×2N, or N×N.", "In addition, the skip mode may be performed only on the partition of 2N×2N.", "The encoding may be independently performed on one prediction unit in a coding unit, thereby selecting a prediction mode having a least encoding error.", "The video encoding apparatus 100 may also perform the transformation on the image data in a coding unit based not only on the coding unit for encoding the image data, but also based on a data unit that is different from the coding unit.", "In order to perform the transformation in the coding unit, the transformation may be performed based on a data unit having a size smaller than or equal to the coding unit.", "For example, the data unit for the transformation may include a data unit for an intra mode and a data unit for an inter mode.", "A data unit used as a base of the transformation will hereinafter be referred to as a “transformation unit.” Similar to the coding unit, the transformation unit in the coding unit may be recursively split into smaller-sized regions, so that residual data in the coding unit may be divided according to the transformation units having the tree structure according to transformation depths.", "A transformation depth indicating the number of splitting times to reach the transformation unit by splitting the height and width of the coding unit may also be set in the transformation unit.", "For example, in a current coding unit of 2N×2N, a transformation depth may be equal to zero when the size of a transformation unit is also 2N×2N, may be equal to one when the size of the transformation unit is thus N×N, and may be equal to two when the size of the transformation unit is thus N/2×N/2.Accordingly, the transformation units having the tree structure may be determined according to transformation depths.", "Encoding information according to coding units corresponding to a coded depth requires not only information relating to the coded depth, but also about information related to prediction encoding and transformation.", "Accordingly, the coding unit determiner 120 not only determines a coded depth having a least encoding error, but also determines a partition type in a prediction unit, a prediction mode according to prediction units, and a size of a transformation unit for transformation.", "Coding units according to a tree structure in a maximum coding unit and a method of determining a partition, according to one or more exemplary embodiments, will be described in detail later with reference to FIGS.", "3 through 12.The coding unit determiner 120 may measure an encoding error of deeper coding units according to depths by using, for example, Rate-Distortion Optimization based on Lagrangian multipliers.", "The output unit 130 outputs the image data of the maximum coding unit, which is encoded based on the at least one coded depth determined by the coding unit determiner 120, and information relating to the encoding mode according to the coded depth, in bitstreams.", "The encoded image data may be obtained by encoding residual data relating to an image.", "The information relating to the encoding mode according to coded depth may include information relating to the coded depth, and/or information relating to the partition type in the prediction unit, the prediction mode, and the size of the transformation unit.", "The information relating to the coded depth may be defined by using split information according to depths, which indicates whether encoding is performed on coding units of a lower depth instead of a current depth.", "If the current depth of the current coding unit is the coded depth, image data in the current coding unit is encoded and outputted, and thus the split information may be defined not to split the current coding unit to a lower depth.", "Alternatively, if the current depth of the current coding unit is not the coded depth, the encoding is performed on the coding unit of the lower depth, and thus the split information may be defined to split the current coding unit to obtain the coding units of the lower depth.", "If the current depth is not the coded depth, encoding is performed on the coding unit that is split into the coding unit of the lower depth.", "Because at least one coding unit of the lower depth exists in one coding unit of the current depth, the encoding is repeatedly performed on each coding unit of the lower depth, and thus the encoding may be recursively performed for the coding units having the same depth.", "Because the coding units having a tree structure are determined for one maximum coding unit, and information relating to at least one encoding mode is determined for a coding unit of a coded depth, information relating to at least one encoding mode may be determined for one maximum coding unit.", "In addition, a coded depth of the image data of the maximum coding unit may vary based on location, because the image data is hierarchically split according to depths, and thus information relating to the coded depth and the encoding mode may be set for the image data.", "Accordingly, the output unit 130 may assign encoding information relating to a corresponding coded depth and an encoding mode to at least one of the coding unit, the prediction unit, and a minimum unit included in the maximum coding unit.", "The minimum unit, according to an exemplary embodiment, is a rectangular data unit obtained by splitting the minimum coding unit constituting the lowermost depth by four.", "Alternatively, the minimum unit may be a maximum rectangular data unit that may be included in all of the coding units, prediction units, partition units, and transformation units included in the maximum coding unit.", "For example, the encoding information outputted through the output unit 130 may be classified into encoding information according to coding units, and encoding information according to prediction units.", "The encoding information according to the coding units may include the information relating to the prediction mode and information relating to the size of the partitions.", "The encoding information according to the prediction units may include information relating to an estimated direction of an inter mode, information relating to a reference image index of the inter mode, information relating to a motion vector, information relating to a chroma component of an intra mode, and information relating to an interpolation method of the intra mode.", "In addition, information relating to a maximum size of the coding unit defined according to pictures, slices, or groups of pictures (GOPs), and information relating to a maximum depth may be inserted into a Sequence Parameter Set (SPS) or a header of a bitstream.", "In the video encoding apparatus 100, the deeper coding unit may be a coding unit obtained by dividing a height or width of a coding unit of an upper depth, which is one layer above, by two.", "In particular, when the size of the coding unit of the current depth is 2N×2N, the size of the coding unit of the lower depth may be equal to N×N.", "In addition, the coding unit of the current depth having the size of 2N×2N may include a maximum of four coding units of the lower depth.", "Accordingly, the video encoding apparatus 100 may form the coding units having the tree structure by determining coding units having an optimum shape and an optimum size for each maximum coding unit, based on the size of the maximum coding unit and the maximum depth, which may be determined by considering characteristics of the current picture.", "In addition, because encoding may be performed on each maximum coding unit by using any one of various prediction modes and transformations, an optimum encoding mode may be determined by considering characteristics of the coding unit of various image sizes.", "Thus, if an image having high resolution or large data amount is encoded in a conventional macroblock, a number of macroblocks per picture excessively increases.", "Accordingly, a number of pieces of compressed information generated for each macroblock increases, and thus it may become difficult to transmit the compressed information, and data compression efficiency may decrease.", "However, by using the video encoding apparatus 100, image compression efficiency may be increased, because a coding unit is adjusted based on considering characteristics of an image relating to increasing a maximum size of a coding unit based on considering a size of the image.", "FIG.", "2 is a block diagram of a video decoding apparatus 200, according to an exemplary embodiment.", "The video decoding apparatus 200 includes a receiver 210, an image data and encoding information extractor 220, and an image data decoder 230.Definitions of various terms, such as a coding unit, a depth, a prediction unit, a transformation unit, and information relating to various encoding modes for various operations of the video decoding apparatus 200, are identical to those described with reference to FIG.", "1 and the video encoding apparatus 100.The receiver 210 receives and parses a bitstream which includes an encoded video.", "The image data and encoding information extractor 220 extracts encoded image data for each coding unit from the parsed bitstream, wherein the coding units have a tree structure according to each maximum coding unit, and outputs the extracted image data to the image data decoder 230.The image data and encoding information extractor 220 may extract information relating to a maximum size of a coding unit of a current picture, from a header relating to the current picture or SPS.", "Further, the image data and encoding information extractor 220 extracts information relating to a coded depth and an encoding mode for the coding units having a tree structure according to each maximum coding unit from the parsed bitstream.", "The extracted information relating to the coded depth and the encoding mode is outputted to the image data decoder 230.In particular, the image data included in a bit stream is split into the maximum coding unit such that the image data decoder 230 decodes the image data for each maximum coding unit.", "The information relating to the coded depth and the encoding mode according to the maximum coding unit may be set for information relating to at least one coding unit corresponding to the coded depth, and information relating to an encoding mode may include information relating to a partition type of a corresponding coding unit corresponding to the coded depth, information relating to a prediction mode, and information relating to a size of a transformation unit.", "In addition, splitting information according to depths may be extracted as the information relating to the coded depth.", "The information relating to the coded depth and the encoding mode according to each maximum coding unit extracted by the image data and encoding information extractor 220 is information relating to a coded depth and an encoding mode determined to generate a minimum encoding error when an encoder, such as the video encoding apparatus 100, repeatedly performs encoding for each deeper coding unit according to depths according to each maximum coding unit.", "Accordingly, the video decoding apparatus 200 may restore an image by decoding the image data according to a coded depth and an encoding mode that generates the minimum encoding error.", "Because encoding information relating to the coded depth and the encoding mode may be assigned to a predetermined data unit from among a corresponding coding unit, a prediction unit, and a minimum unit, the image data and encoding information extractor 220 may extract the information relating to the coded depth and the encoding mode according to the predetermined data units.", "The predetermined data units to which the same information relating to the coded depth and the encoding mode is assigned may be inferred to be the data units included in the same maximum coding unit.", "The image data decoder 230 restores the current picture by decoding the image data in each maximum coding unit based on the information relating to the coded depth and the encoding mode according to the maximum coding units.", "In particular, the image data decoder 230 may decode the encoded image data based on the extracted information relating to the partition type, the prediction mode, and the transformation unit for each coding unit from among the coding units having the tree structure included in each maximum coding unit.", "A decoding process may include a prediction including intra prediction and motion compensation, and an inverse transformation.", "The image data decoder 230 may perform intra prediction or motion compensation according to a partition and a prediction mode of each coding unit, based on the information relating to the partition type and the prediction mode of the prediction unit of the coding unit according to coded depths.", "Further, the image data decoder 230 may perform inverse transformation according to each transformation unit in the coding unit, based on the information relating to the size of the transformation unit of the coding unit according to coded depths, so as to perform the inverse transformation according to maximum coding units.", "The image data decoder 230 may determine at least one coded depth of a current maximum coding unit by using split information according to depths.", "If the split information indicates that image data is no longer split in the current depth, the current depth is a coded depth.", "Accordingly, the image data decoder 230 may decode encoded data of at least one coding unit corresponding to the each coded depth in the current maximum coding unit by using the information relating to the partition type of the prediction unit, the prediction mode, and the size of the transformation unit for each coding unit corresponding to the coded depth, and output the image data of the current maximum coding unit.", "In particular, data units containing the encoding information including the same split information may be gathered by observing the encoding information set assigned for the predetermined data unit from among the coding unit, the prediction unit, and the minimum unit, and the gathered data units may be considered to be one data unit to be decoded by the image data decoder 230 in the same encoding mode.", "The video decoding apparatus 200 may obtain information relating to at least one coding unit that generates the minimum encoding error when encoding is recursively performed for each maximum coding unit, and may use the information to decode the current picture.", "In particular, the coding units having the tree structure determined to be the optimum coding units in each maximum coding unit may be decoded.", "In addition, the maximum size of coding unit may be determined by considering resolution and an amount of image data.", "Accordingly, even if image data has high resolution and a large amount of data, the image data may be efficiently decoded and restored by using a size of a coding unit and an encoding mode, which are adaptively determined according to characteristics of the image data, by using information relating to an optimum encoding mode received from an encoder.", "A method for determining coding units having a tree structure, a prediction unit, and a transformation unit, according to an exemplary embodiment, will now be described with reference to FIGS.", "3 through 15.FIG.", "3 is a diagram which illustrates a concept of coding units according to an exemplary embodiment.", "A size of a coding unit may be expressed as width×height, and may be equal to, for example, one of 64×64, 32×32, 16×16, and 8×8.A coding unit of 64×64 may be split into partitions of 64×64, 64×32, 32×64, or 32×32, and a coding unit of 32×32 may be split into partitions of 32×32, 32×16, 16×32, or 16×16.A coding unit of 16×16 may be split into partitions of 16×16, 16×8, 8×16, or 8×8, and a coding unit of 8×8 may be split into partitions of 8×8, 8×4, 4×8, or 4×4.In video data 310, a resolution is 1920×1080, a maximum size of a coding unit is equal to 64, and a maximum depth is equal to 2.In video data 320, a resolution is 1920×1080, a maximum size of a coding unit is equal to 64, and a maximum depth is equal to 4.In video data 330, a resolution is 352×288, a maximum size of a coding unit is equal to 16, and a maximum depth is equal to 2.Each maximum depth shown in FIG.", "3 denotes a total number of splits from a maximum coding unit to a minimum decoding unit.", "If a resolution is high or a data amount is large, a maximum size of a coding unit may be large so as to not only increase encoding efficiency but also to accurately reflect characteristics of an image.", "Accordingly, the maximum size of the coding unit of the video data 310 and 320 having the higher resolution than the video data 330 may be equal to 64.Because the maximum depth of the video data 310 is equal to 2, coding units 315 of the video data 310 may include a maximum coding unit having a long axis size of 64, and coding units having long axis sizes of 32 and 16, because depths are increased to two layers by splitting the maximum coding unit twice.", "Further, because the maximum depth of the video data 330 is equal to 2, coding units 335 of the video data 330 may include a maximum coding unit having a long axis size of 16, and coding units having a long axis size of 8 and 4, because depths are increased to two layers by splitting the maximum coding unit twice.", "Because the maximum depth of the video data 320 is 4, coding units 325 of the video data 320 may include a maximum coding unit having a long axis size of 64, and coding units having long axis sizes of 32, 16, 8, and 4, because the depths are increased to 4 layers by splitting the maximum coding unit four times.", "As a depth increases, detailed information may be more precisely expressed.", "FIG.", "4 is a block diagram of an image encoder 400 based on coding units, according to an exemplary embodiment.", "The image encoder 400 performs similar operations as those performed by the coding unit determiner 120 of the video encoding apparatus 100 for encoding image data.", "In particular, an intra predictor 410 performs intra prediction on coding units in an intra mode, from among a current frame 405, and a motion predictor 420 and a motion compensator 425 respectively perform inter estimation and motion compensation on coding units in an inter mode from among the current frame 405 by using the current frame 405 and a reference frame 495.Data outputted from the intra predictor 410, the motion predictor 420, and the motion compensator 425 is outputted as a quantized transformation coefficient through a transformer 430 and a quantizer 440.The quantized transformation coefficient is restored as data in a spatial domain via operations performed by an inverse quantizer 460 and an inverse transformer 470, and the restored data in the spatial domain is outputted as the reference frame 495 after being post-processed by each of a deblocking unit 480 and a loop filtering unit 490.The quantized transformation coefficient may be outputted as a bitstream 455 via an entropy encoder 450.In order for the image encoder 400 to be applied in the video encoding apparatus 100, all elements of the image encoder 400, i.e., the intra predictor 410, the motion predictor 420, the motion compensator 425, the transformer 430, the quantizer 440, the entropy encoder 450, the inverse quantizer 460, the inverse transformer 470, the deblocking unit 480, and the loop filtering unit 490, perform operations based on each coding unit from among coding units having a tree structure and based on the maximum depth of each maximum coding unit.", "In particular, the each of intra predictor 410, the motion predictor 420, and the motion compensator 425 determines partitions and a prediction mode of each coding unit from among the coding units having a tree structure based on the maximum size and the maximum depth of a current maximum coding unit, and the transformer 430 determines the size of the transformation unit in each coding unit from among the coding units having a tree structure.", "FIG.", "5 is a block diagram of an image decoder 500 based on coding units, according to an exemplary embodiment.", "A parser 510 parses encoded image data to be decoded and information relating to encoding required for decoding from a bitstream 505.The encoded image data is outputted as inverse quantized data via operations performed by an entropy decoder 520 and an inverse quantizer 530, and the inverse quantized data is restored to image data in a spatial domain via an operation performed by an inverse transformer 540.An intra predictor 550 performs intra prediction on coding units in an intra mode with respect to the image data in the spatial domain, and a motion compensator 560 performs motion compensation on coding units in an inter mode by using a reference frame 585.The image data in the spatial domain, having passed through the intra predictor 550 and the motion compensator 560, may be outputted as a restored frame 595 after being post-processed by a deblocking unit 570 and a loop filtering unit 580.In addition, the image data that is post-processed by the deblocking unit 570 and the loop filtering unit 580 may be outputted as the reference frame 585.In order to decode the image data in the image data decoder 230 of the video decoding apparatus 200, the image decoder 500 may perform operations that are performed after completion of operations performed by the parser 510.In order for the image decoder 500 to be applied in the video decoding apparatus 200, all elements of the image decoder 500, i.e., the parser 510, the entropy decoder 520, the inverse quantizer 530, the inverse transformer 540, the intra predictor 550, the motion compensator 560, the deblocking unit 570, and the loop filtering unit 580, perform operations based on coding units having a tree structure for each maximum coding unit.", "In particular, each of the intra predictor 550 and the motion compensator 560 performs operations based on partitions and a prediction mode for each of the coding units having a tree structure, and the inverse transformer 540 performs operations based on a size of a transformation unit for each coding unit.", "FIG.", "6 is a diagram which illustrates deeper coding units according to depths and partitions, according to an exemplary embodiment.", "The video encoding apparatus 100 and the video decoding apparatus 200 use hierarchical coding units so as to consider characteristics of an image.", "A maximum height, a maximum width, and a maximum depth of each of respective coding units may be adaptively determined according to the characteristics of the image, or may be variably set by a user.", "Sizes of deeper coding units according to depths may be determined according to the predetermined maximum size of the coding unit.", "In a hierarchical structure 600 of coding units, according to an exemplary embodiment, the maximum height and the maximum width of the coding units are each equal to 64, and the maximum depth is equal to 4.Because a depth increases along a vertical axis of the hierarchical structure 600, a height and a width of the deeper coding unit are each split.", "In addition, a prediction unit and partitions, which are bases for prediction encoding of each deeper coding unit, are shown along a horizontal axis of the hierarchical structure 600.In particular, a coding unit 610 is a maximum coding unit in the hierarchical structure 600, wherein a depth is equal to zero and a size, i.e., a height by width specification, is 64×64.The depth increases along the vertical axis, and thus, a coding unit 620 having a size of 32×32 and a depth of 1, a coding unit 630 having a size of 16×16 and a depth of 2, a coding unit 640 having a size of 8×8 and a depth of 3, and a coding unit 650 having a size of 4×4 and a depth of 4 exist.", "The coding unit 650 having the size of 4×4 and the depth of 4 is a minimum coding unit.", "The prediction unit and the partitions of a coding unit are arranged along the horizontal axis according to each depth.", "In particular, if the coding unit 610 having the size of 64×64 and the depth of 0 is a prediction unit, the prediction unit may be split into partitions included in the coding unit 610, i.e., a partition 610 having a size of 64×64, partitions 612 having the size of 64×32, partitions 614 having the size of 32×64, or partitions 616 having the size of 32×32.Similarly, a prediction unit of the coding unit 620 having the size of 32×32 and the depth of 1 may be split into partitions included in the coding unit 620, i.e., a partition 620 having a size of 32×32, partitions 622 having a size of 32×16, partitions 624 having a size of 16×32, or partitions 626 having a size of 16×16.Similarly, a prediction unit of the coding unit 630 having the size of 16×16 and the depth of 2 may be split into partitions included in the coding unit 630, i.e., a partition having a size of 16×16 included in the coding unit 630, partitions 632 having a size of 16×8, partitions 634 having a size of 8×16, or partitions 636 having a size of 8×8.Similarly, a prediction unit of the coding unit 640 having the size of 8×8 and the depth of 3 may be split into partitions included in the coding unit 640, i.e., a partition having a size of 8×8 included in the coding unit 640, partitions 642 having a size of 8×4, partitions 644 having a size of 4×8, or partitions 646 having a size of 4×4.The coding unit 650 having the size of 4×4 and the depth of 4 is the minimum coding unit and a coding unit of the lowermost depth.", "A prediction unit of the coding unit 650 is only assigned to a partition having a size of 4×4.In order to determine the at least one coded depth of the coding units constituting the maximum coding unit 610, the coding unit determiner 120 of the video encoding apparatus 100 performs encoding for coding units corresponding to each depth included in the maximum coding unit 610.A number of deeper coding units according to depths including data in the same range and the same size increases as the depth increases.", "For example, four coding units corresponding to a depth of 2 are required to cover data that is included in one coding unit corresponding to a depth of 1.Accordingly, in order to compare encoding results of the same data according to depths, the coding unit corresponding to the depth of 1 and four coding units corresponding to the depth of 2 are each encoded.", "In order to perform encoding for a current depth from among the depths, a least encoding error may be selected for the current depth by performing encoding for each prediction unit in the coding units corresponding to the current depth, along the horizontal axis of the hierarchical structure 600.Alternatively, the minimum encoding error may be searched for by comparing the least encoding errors according to depths, by performing encoding for each depth as the depth increases along the vertical axis of the hierarchical structure 600.A depth and a partition having the minimum encoding error in the coding unit 610 may be selected as the coded depth and a partition type of the coding unit 610.FIG.", "7 is a diagram which illustrates a relationship between a coding unit 710 and transformation units 720, according to an exemplary embodiment.", "The video encoding apparatus 100 or 200 encodes or decodes an image according to coding units having sizes smaller than or equal to a maximum coding unit for each maximum coding unit.", "Sizes of transformation units for transformation during encoding may be selected based on data units that are not larger than a corresponding coding unit.", "For example, in the video encoding apparatus 100 or 200, if a size of the coding unit 710 is 64×64, transformation may be performed by using the transformation units 720 having a size of 32×32.Further, data of the coding unit 710 having the size of 64×64 may be encoded by performing the transformation on each of the transformation units having the size of 32×32, 16×16, 8×8, and 4×4, which are smaller than 64×64, and then a transformation unit having the least coding error may be selected.", "FIG.", "8 is a diagram which illustrates encoding information relating to coding units corresponding to a coded depth, according to an exemplary embodiment.", "The output unit 130 of the video encoding apparatus 100 may encode and transmit information 800 relating to a partition type, information 810 relating to a prediction mode, and information 820 relating to a size of a transformation unit for each coding unit corresponding to a coded depth, as information relating to an encoding mode.", "The information 800 indicates information relating to a shape of a partition obtained by splitting a prediction unit of a current coding unit, wherein the partition is a data unit for prediction encoding the current coding unit.", "For example, a current coding unit CU_0 having a size of 2N×2N may be split into any one of a partition 802 having a size of 2N×2N, a partition 804 having a size of 2N×N, a partition 806 having a size of N×2N, and a partition 808 having a size of N×N.", "In particular, the information 800 relating to a partition type is set to indicate one of the partition 804 having a size of 2N×N, the partition 806 having a size of N×2N, and the partition 808 having a size of N×N.", "The information 810 indicates a prediction mode of each partition.", "For example, the information 810 may indicate a mode of prediction encoding performed on a partition indicated by the information 800, i.e., an intra mode 812, an inter mode 814, or a skip mode 816.The information 820 indicates a transformation unit to be based on when transformation is performed on a current coding unit.", "For example, the transformation unit may be a first intra transformation unit 822, a second intra transformation unit 824, a first inter transformation unit 826, or a second inter transformation unit 828.The image data and encoding information extractor 220 of the video decoding apparatus 200 may extract and use the information 800, 810, and 820 for decoding, according to each deeper coding unit.", "FIG.", "9 is a diagram which illustrates deeper coding units according to depths, according to an exemplary embodiment.", "Split information may be used to indicate a change of a depth.", "The spilt information indicates whether a coding unit of a current depth is split into coding units of a lower depth.", "A prediction unit 910 for prediction encoding a coding unit 900 having a depth of 0 and a size of 2N_0×2N_0 may include partitions of a partition type 912 having a size of 2N_0×2N_0, a partition type 914 having a size of 2N_0×N_0, a partition type 916 having a size of N_0×2N_0, and a partition type 918 having a size of N_0×N_0.FIG.", "9 only illustrates the partition types 912 through 918 which are obtained by symmetrically splitting the prediction unit 910, but a partition type is not limited thereto, and the partitions of the prediction unit 910 may include asymmetrical partitions, partitions having a predetermined shape, and partitions having a geometrical shape.", "Prediction encoding is repeatedly performed on one partition having a size of 2N_0×2N_0, two partitions having a size of 2N_0×N_0, two partitions having a size of N_0×2N_0, and four partitions having a size of N_0×N_0, according to each partition type.", "The prediction encoding in an intra mode and an inter mode may be performed on the partitions having the sizes of 2N_0×2N_0, N_0×2N_0, 2N_0×N_0, and N_0×N_0.The prediction encoding in a skip mode is performed only on the partition having the size of 2N_0×2N_0.Errors of encoding, including the prediction encoding, in the partition types 912 through 918 are compared, and the least encoding error is determined among the partition types.", "If an encoding error is smallest in one of the partition types 912 through 916, the prediction unit 910 may not be split into a lower depth.", "If the encoding error is the smallest in the partition type 918, a depth is changed from 0 to 1 to split the partition type 918 in operation 920, and encoding is repeatedly performed on coding units 930 having a depth of 2 and a size of N_0×N_0 to search for a minimum encoding error.", "A prediction unit 940 for prediction encoding the coding unit 930 having a depth of 1 and a size of 2N_1×2N_1 (=N_0×N_0) may include partitions of a partition type 942 having a size of 2N_1×2N_1, a partition type 944 having a size of 2N_1×N_1, a partition type 946 having a size of N_1×2N_1, and a partition type 948 having a size of N_1×N_1.If an encoding error is the smallest in the partition type 948, a depth is changed from 1 to 2 to split the partition type 948 in operation 950, and encoding is repeatedly performed on coding units 960, which have a depth of 2 and a size of N_2×N_2 to search for a minimum encoding error.", "When a maximum depth is d, split operation according to each depth may be performed up to when a depth becomes d−1, and split information may be encoded as up to when a depth is one of 0 to d−2.In particular, when encoding is performed up to when the depth is d−1 after a coding unit corresponding to a depth of d−2 is split in operation 970, a prediction unit 990 for prediction encoding a coding unit 980 having a depth of d−1 and a size of 2N_(d−1)×2N_(d−1) may include partitions of a partition type 992 having a size of 2N_(d−1)×2N_(d−1), a partition type 994 having a size of 2N_(d−1)×N_(d−1), a partition type 996 having a size of N_(d−1)×2N_(d−1), and a partition type 998 having a size of N_(d−1)×N_(d−1).", "Prediction encoding may be repeatedly performed on one partition having a size of 2N_(d−1)×2N_(d−1), two partitions having a size of 2N_(d−1)×N_(d−1), two partitions having a size of N_(d−1)×2N_(d−1), or four partitions having a size of N_(d−1)×N_(d−1) from among the partition types 992 through 998 to search for a partition type having a minimum encoding error.", "Even when the partition type 998 has the minimum encoding error, because a maximum depth is d, a coding unit CU_(d−1) having a depth of d−1 is no longer split to a lower depth, and a coded depth for the coding units constituting a current maximum coding unit 900 is determined to be d−1 and a partition type of the current maximum coding unit 900 may be determined to be N_(d−1)×N_(d−1).", "In addition, because the maximum depth is d and a minimum coding unit 980 having a lowermost depth of d−1 is no longer split to a lower depth, split information for the minimum coding unit 980 is not set.", "A data unit 999 may be a “minimum unit” for the current maximum coding unit.", "A minimum unit according to an exemplary embodiment may be a rectangular data unit obtained by splitting a minimum coding unit 980 by four.", "By performing the encoding repeatedly, the video encoding apparatus 100 may select a depth having the least encoding error by comparing encoding errors according to depths of the coding unit 900 to determine a coded depth, and set a corresponding partition type and a prediction mode as an encoding mode of the coded depth.", "Accordingly, the minimum encoding errors according to depths are compared in all of the depths of 1 through d, and a depth having the least encoding error may be determined as a coded depth.", "The coded depth, the partition type of the prediction unit, and the prediction mode may be encoded and transmitted as information relating to an encoding mode.", "In addition, because a coding unit is split from a depth of 0 to a coded depth, only split information of the coded depth is set to 0, and split information of depths excluding the coded depth is set to 1.The image data and encoding information extractor 220 of the video decoding apparatus 200 may extract and use the information relating to the coded depth and the prediction unit of the coding unit 900 to decode the partition 912.The video decoding apparatus 200 may determine a depth, in which split information is equal to 0, as a coded depth by using split information according to depths, and use information relating to an encoding mode of the corresponding depth for decoding.", "FIGS.", "10, 11, and 12 are diagrams which illustrate a relationship between coding units 1010, prediction units 1060, and transformation units 1070, according to an exemplary embodiment.", "The coding units 1010 are coding units having a tree structure, corresponding to coded depths determined by the video encoding apparatus 100, in a maximum coding unit.", "The prediction units 1060 are partitions of prediction units of each of the coding units 1010, and the transformation units 1070 are transformation units of each of the coding units 1010.When a depth of a maximum coding unit is equal to 0 in the coding units 1010, depths of coding units 1012 and 1054 are equal to 1, depths of coding units 1014, 1016, 1018, 1028, 1050, and 1052 are equal to 2, depths of coding units 1020, 1022, 1024, 1026, 1030, 1032, and 1048 are equal to 3, and depths of coding units 1040, 1042, 1044, and 1046 are equal to 4.In the prediction units 1060, some coding units 1014, 1016, 1022, 1032, 1048, 1050, 1052, and 1054 are obtained by splitting the coding units in the coding units 1010.In particular, partition types in the coding units 1014, 1022, 1050, and 1054 have a size of 2N×N, partition types in the coding units 1016, 1048, and 1052 have a size of N×2N, and a partition type of the coding unit 1032 has a size of N×N.", "Prediction units and partitions of the coding units 1010 are smaller than or equal to each coding unit.", "Transformation or inverse transformation is performed on image data of the coding unit 1052 in the transformation units 1070 in a data unit that is smaller than the coding unit 1052.In addition, the coding units 1014, 1016, 1022, 1032, 1048, 1050, and 1052 in the transformation units 1070 are different from those in the prediction units 1060 with respect to sizes and shapes.", "In particular, the video encoding and decoding apparatuses 100 and 200 may perform intra prediction, motion prediction, motion compensation, transformation, and inverse transformation individually on a data unit in the same coding unit.", "Accordingly, encoding is recursively performed on each of coding units having a hierarchical structure in each region of a maximum coding unit to determine an optimum coding unit, and thus coding units having a recursive tree structure may be obtained.", "Encoding information may include split information relating to a coding unit, information relating to a partition type, information relating to a prediction mode, and information relating to a size of a transformation unit.", "Table 1 shows the encoding information that may be set by the video encoding and decoding apparatuses 100 and 200.TABLE 1 Split Information 0 (Encoding on Coding Unit having Size of 2N × 2N and Current Depth of d) Size of Transformation Unit Split Split Partition Type Information 0 Information 1 Symmetrical Asymmetrical of of Prediction Partition Partition Transformation Transformation Split Mode Type Type Unit Unit Information 1 Intra 2N × 2N 2N × nU 2N × 2N N × N Repeatedly Inter 2N × N 2N × nD (Symmetrical Encode Skip N × 2N nL × 2N Type) Coding (Only N × N nR × 2N N/2 × N/2 Units 2N × 2N) (Asymmetrical having Type) Lower Depth of d + 1 The output unit 130 of the video encoding apparatus 100 may output the encoding information relating to the coding units having a tree structure, and the image data and encoding information extractor 220 of the video decoding apparatus 200 may extract the encoding information relating to the coding units having a tree structure from a received bitstream.", "Split information indicates whether a current coding unit is split into coding units of a lower depth.", "If split information of a current depth d is equal to 0, a depth in which a current coding unit is no longer split into a lower depth is a coded depth, and thus information relating to a partition type, prediction mode, and a size of a transformation unit may be defined for the coded depth.", "If the current coding unit is further split according to the split information, encoding is independently performed on four split coding units of a lower depth.", "A prediction mode may be one of an intra mode, an inter mode, and a skip mode.", "The intra mode and the inter mode may be defined in all partition types, and the skip mode is defined only in a partition type having a size of 2N×2N.", "The information relating to the partition type may indicate symmetrical partition types having sizes of 2N×2N, 2N×N, N×2N, and N×N, which are obtained by symmetrically splitting a height or a width of a prediction unit, and asymmetrical partition types having sizes of 2N×nU, 2N×nD, nL×2N, and nR×2N, which are obtained by asymmetrically splitting the height or width of the prediction unit.", "The asymmetrical partition types having the sizes of 2N×nU and 2N×nD may be respectively obtained by splitting the height of the prediction unit by ratios of 1:3 and 3:1, and the asymmetrical partition types having the sizes of nL×2N and nR×2N may be respectively obtained by splitting the width of the prediction unit by ratios of 1:3 and 3:1 The size of the transformation unit may be set to be two types in the intra mode and two types in the inter mode.", "In particular, if split information of the transformation unit is equal to 0, the size of the transformation unit may be 2N×2N, which is the size of the current coding unit.", "If split information of the transformation unit is equal to 1, the transformation units may be obtained by splitting the current coding unit.", "Further, if a partition type of the current coding unit having the size of 2N×2N is a symmetrical partition type, a size of a transformation unit may be N×N, and if the partition type of the current coding unit is an asymmetrical partition type, the size of the transformation unit may be N/2×N/2.The encoding information relating to coding units having a tree structure may include at least one of a coding unit corresponding to a coded depth, a prediction unit, and a minimum unit.", "The coding unit corresponding to the coded depth may include at least one of a prediction unit and a minimum unit containing the same encoding information.", "Accordingly, it is determined whether adjacent data units are included in the same coding unit corresponding to the coded depth by comparing encoding information of the adjacent data units.", "In addition, a corresponding coding unit corresponding to a coded depth is determined by using encoding information of a data unit, and thus a distribution of coded depths in a maximum coding unit may be determined.", "Accordingly, if a current coding unit is predicted based on encoding information of adjacent data units, encoding information of data units in deeper coding units adjacent to the current coding unit may be directly referred to and used.", "Alternatively, if a current coding unit is predicted based on encoding information of adjacent data units, data units adjacent to the current coding unit are searched using encoded information of the data units, and the searched adjacent coding units may be referred for predicting the current coding unit.", "FIG.", "13 is a diagram which illustrates a relationship between a coding unit, a prediction unit or a partition, and a transformation unit, according to encoding mode information included in Table 1.A maximum coding unit 1300 includes coding units 1302, 1304, 1306, 1312, 1314, 1316, and 1318 of respective coded depths.", "In particular, because the coding unit 1318 is a coding unit of a coded depth, split information may be set equal to 0.Information relating to a partition type of the coding unit 1318 having a size of 2N×2N may be set to be one of a partition type 1322 having a size of 2N×2N, a partition type 1324 having a size of 2N×N, a partition type 1326 having a size of N×2N, a partition type 1328 having a size of N×N, a partition type 1332 having a size of 2N×nU, a partition type 1334 having a size of 2N×nD, a partition type 1336 having a size of nL×2N, and a partition type 1338 having a size of nR×2N.", "When the partition type is set to be symmetrical, i.e., the partition type 1322, 1324, 1326, or 1328, a transformation unit 1342 having a size of 2N×2N is set if split information (i.e., a TU size flag) of a transformation unit is equal to 0, and a transformation unit 1344 having a size of N×N is set if a TU size flag is equal to 1.When the partition type is set to be asymmetrical, i.e., the partition type 1332, 1334, 1336, or 1338, a transformation unit 1352 having a size of 2N×2N is set if a TU size flag is equal to 0, and a transformation unit 1354 having a size of N/2×N/2 is set if a TU size flag is equal to 1.The TU size flag may be a flag having a value equal to either 0 or 1, but the TU size flag is not limited to one bit, and a transformation unit may be hierarchically split into a tree structure in accordance with an increase in the TU size flag from 0.In particular, the size of a transformation unit that has been actually used may be expressed by using a TU size flag of a transformation unit, according to an exemplary embodiment, together with a maximum size and minimum size of the transformation unit.", "According to an exemplary embodiment, the video encoding apparatus 100 may encode maximum transformation unit size information, minimum transformation unit size information, and a maximum TU size flag.", "The result of encoding the maximum transformation unit size information, the minimum transformation unit size information, and the maximum TU size flag may be inserted into an SPS.", "According to an exemplary embodiment, the video decoding apparatus 200 may decode video by using the maximum transformation unit size information, the minimum transformation unit size information, and the maximum TU size flag.", "For example, if the size of a current coding unit is 64×64 and a maximum transformation unit size is 32×32, then the size of a transformation unit may be 32×32 when a TU size flag is 0, the size of the transformation unit may be 16×16 when the TU size flag is 1, and the size of the transformation unit may be 8×8 when the TU size flag is 2.As another example, if the size of the current coding unit is 32×32 and a minimum transformation unit size is 32×32, then the size of the transformation unit may be 32×32 when the TU size flag is 0.In this example, the TU size flag cannot be set to a value other than 0, because the size of the transformation unit cannot be less than 32×32.As another example, if the size of the current coding unit is 64×64 and a maximum TU size flag is 1, then the TU size flag may be equal to either 0 or 1.In particular, the TU size flag cannot be set to a value other than 0 or 1.Thus, if it is defined that the maximum TU size flag is “MaxTransformSizeIndex”, a minimum transformation unit size is defined as “MinTransformSize”, and a transformation unit size is defined as “RootTuSize” when the TU size flag is 0, then a current minimum transformation unit size “CurrMinTuSize” that can be determined in a current coding unit, may be defined by Equation (E1): CurrMinTuSize=max(MinTransformSize, RootTuSize/(2̂MaxTransformSizeIndex)) (E1) By comparison with the current minimum transformation unit size “CurrMinTuSize” that can be determined in the current coding unit, a transformation unit size “RootTuSize” when the TU size flag is equal to 0 may denote a maximum transformation unit size that can be selected in the system.", "In Equation (E1), “RootTuSize/(2̂MaxTransformSizeIndex)” denotes a transformation unit size when the transformation unit size “RootTuSize”, when the TU size flag is equal to 0, is split a number of times corresponding to the maximum TU size flag, and “MinTransformSize” denotes a minimum transformation size.", "Thus, a smaller value from among “RootTuSize/(2̂MaxTransformSizeIndex)” and “MinTransformSize” may be the current minimum transformation unit size “CurrMinTuSize” that can be determined in the current coding unit.", "According to an exemplary embodiment, the maximum transformation unit size RootTuSize may vary according to the type of a prediction mode.", "For example, if a current prediction mode is an inter mode, then “RootTuSize” may be determined by using Equation (E2) below.", "In Equation (E2), “MaxTransformSize” denotes a maximum transformation unit size, and “PUSize” denotes a current prediction unit size.", "RootTuSize=min(MaxTransformSize,PUSize) (E2) In particular, if the current prediction mode is the inter mode, the transformation unit size “RootTuSize” when the TU size flag is 0 may be a smaller value from among the maximum transformation unit size and the current prediction unit size.", "If a prediction mode of a current partition unit is an intra mode, “RootTuSize” may be determined by using Equation (E3) below.", "In Equation (E3), “PartitionSize” denotes the size of the current partition unit.", "RootTuSize=min(MaxTransformSize,PartitionSize) (E3) In particular, if the current prediction mode is the intra mode, the transformation unit size “RootTuSize” when the TU size flag is 0 may be a smaller value from among the maximum transformation unit size and the size of the current partition unit.", "However, the current maximum transformation unit size “RootTuSize” that varies according to the type of a prediction mode in a partition unit is just an example and is not limited thereto.", "FIG.", "14 is a flowchart which illustrates a method for encoding a video, according to an exemplary embodiment.", "In operation 1210, at least one region of a current picture is assigned, or split, into at least one maximum coding unit.", "A maximum depth indicating the total number of possible splitting times may be predetermined.", "In operation 1220, a coded depth to output a final encoding result according to at least one split region, which is obtained by splitting a region of each maximum coding unit according to depths, is determined by encoding the at least one split region, and a coding unit according to a tree structure is determined.", "The maximum coding unit is spatially split whenever the depth increases, and thus the maximum coding unit is split into coding units of a lower depth.", "Each coding unit may be split into coding units of another lower depth by being spatially split independently from adjacent coding units.", "Encoding is repeatedly performed on each coding unit according to depths.", "Further, a transformation unit according to partition types having the least encoding error is determined for each deeper coding unit.", "In order to determine a coded depth having a minimum encoding error in each maximum coding unit, encoding errors may be measured and compared in all deeper coding units according to depths.", "In operation 1230, encoded image data that is a final result of encoding the at least one split region and encoded information relating to the coded depth and an encoding mode are outputted according to the at least one maximum coding unit.", "The information relating to the encoding mode may include information relating to a coded depth or split information, and information relating to a partition type of a prediction unit, a prediction mode, and a size of a transformation unit.", "The encoded information relating to the encoding mode may be transmitted to a decoder with the encoded image data.", "FIG.", "15 is a flowchart which illustrates a method for decoding a video, according to an exemplary embodiment.", "In operation 1310, a bitstream which includes an encoded video is received and parsed.", "In operation 1320, encoded image data relating to a current picture assigned to a maximum coding unit, and information relating to a coded depth and an encoding mode according to maximum coding units are extracted from the parsed bitstream.", "The coded depth of each maximum coding unit is a depth having the least encoding error in each maximum coding unit.", "In encoding each maximum coding unit, the image data is encoded based on at least one data unit obtained by hierarchically splitting the each maximum coding unit according to depths.", "According to the information relating to the coded depth and the encoding mode, the maximum coding unit may be split into coding units having a tree structure.", "Each of the coding units having the tree structure is determined as a coding unit corresponding to a coded depth, and is optimally encoded so as to output the least encoding error.", "Accordingly, encoding and decoding efficiency with respect to an image may be improved by decoding each piece of encoded image data in the coding units after determining at least one coded depth according to coding units.", "In operation 1330, the image data relating to each maximum coding unit is decoded based on the information relating to the coded depth and the encoding mode according to the maximum coding units.", "The decoded image data may be reproduced by a reproducing apparatus, stored in a storage medium, or transmitted via a network.", "Encoding and decoding of video, which is performed based on spatially hierarchical data units and by using adaptive loop filtering, will be described in greater detail with reference to FIGS.", "16 to 21 below.", "FIG.", "16 is a block diagram of a video encoding apparatus 1400 which uses loop filtering performed by using continuous one-dimensional (1D) filtering, according to an exemplary embodiment.", "The video encoding apparatus 1400 includes a maximum coding unit splitter 1410, a coding unit determiner 1420, and an output unit 1460.The output unit 1460 includes an encoded image data output unit 1430, an encoding information output unit 1440, and a loop filter coefficient information output unit 1450.Operations of the maximum coding unit splitter 1410 and the coding unit determiner 1420 are respectively the same as those of the maximum coding unit splitter 110 and the coding unit determiner 120 included in the video encoding apparatus 100 described above with reference to FIG.", "1.The encoded image data output unit 1430 and the encoding information output unit 1440 perform some of the same operations as those of the output unit 130 of the video encoding apparatus 100 of FIG.", "1.By comparison with the video encoding apparatus 100, the video encoding apparatus 1400 performs video encoding that includes loop filtering by using the continuous 1D filtering.", "The loop filtering performed by the video encoding apparatus 1400 according to an exemplary embodiment will now be described in detail.", "According to an exemplary embodiment, the maximum coding unit splitter 1410 may split a current picture of an image, based on a maximum coding unit for the current picture.", "The coding unit determiner 1420 encodes image data in units of coding units according to depths, for each of maximum coding units, and determines a coded depth for outputting a final encoding result, in units of at least one split region of the current picture.", "According to an exemplary embodiment, the encoded image data output unit 1430 outputs a bitstream which includes the image data that has been encoded in units of maximum coding units, based on the coded depth.", "The encoding information output unit 1440 encodes and outputs information relating to encoding modes according to depths, in units of the maximum coding units.", "According to an exemplary embodiment, the loop filter coefficient information output unit 1450 encodes and outputs filter coefficient information relating to loop filtering performed by using the continuous 1D filtering, during encoding of the current picture and after deblocking is performed.", "According to an exemplary embodiment, loop filtering is performed by continuously performing filtering by using a plurality of 1D filters.", "Loop filtering may be separately performed on luma components and chroma components.", "If the video encoding apparatus 1400 according to the current embodiment corresponds to the image encoder 400 of FIG.", "4, then a quantized transformation coefficient is restored to temporal-domain data by operation of the inverse quantizer 460 and the inverse transformer 470.Then, the restored temporal-domain data is sequentially processed by the deblocking unit 480 and the loop filtering unit 490 to obtain a reference frame 495.According to an exemplary embodiment, the loop filter coefficient information output unit 1450 may encode and output a filter coefficient used in the loop filtering unit 490.The encoded filter coefficient information includes filter coefficient information regarding respective 1D filters.", "The filter coefficient information relating to each of the 1D filters may include information relating to the respective difference between a corresponding pair of continuous filter coefficients thereof.", "In particular, a residual component between a respective pair of filter coefficients of each of the 1D filters may be encoded.", "Specifically, the loop filter coefficient information output unit 1450 may encode the respective difference between a current filter coefficient and a corresponding previous filter coefficient of each of the 1D filters, as residual information.", "In the continuous 1D filtering, filtering may be successively and/or continuously performed by using each of a horizontal 1D filter and a vertical 1D filter.", "In particular, in one example, horizontal 1D filtering may be performed on nine pieces of continuous deblocked data arranged in a horizontal direction, and then, vertical 1D filtering may be continuously performed on nine pieces of continuous deblocked data arranged in a vertical direction.", "In this example, the horizontal 1D filter and the vertical 1D filter may be symmetrical to each other, and the total number of filter coefficients of each of the horizontal 1D filter and the vertical 1D filter may be five.", "Filter coefficients of each of 1D filters may be determined based on a Wiener filter approach.", "According to an exemplary embodiment, the video encoding apparatus 1400 may determine the filter coefficient information, e.g., a total number, sizes, and types of 1D filters, quantization bits, coefficients, a filtering direction, whether filtering is to be performed, and whether running filtering is to be performed, and may then encode and transmit information relating to a set of 1D filters that perform loop filtering, together with the filter coefficient information.", "The information relating to the set of 1D filters may be set in units of data units, e.g., pictures, slices, or sequences.", "For example, the 1D filters may be Wiener filters or another predetermined type of filter that includes symmetrical or asymmetrical filters.", "If the 1D filters are the Wiener filters, filter coefficients thereof may be determined by a cross-correlation matrix between the 1D filters.", "Thus, the filter coefficient information may include information regarding the cross-correlation matrix other than the filter coefficients of the 1D filters.", "The filtering direction of each of the 1D filters may be a direction in which filtering is performed on pixels arranged on a straight line having a predetermined angle.", "For example, 1D filtering may be performed in a filtering direction having an angle of any value between ±0 and 180°, e.g., a vertical direction at an angle of ±90°, a horizontal direction at an angle of 0° or 180°, or a diagonal direction at an angle of ±45° or ±135°.", "Alternatively, the filtering direction of each of the 1D filters may be determined adaptively based on the characteristics of a local image included in the image data.", "For example, a filter may be set in such a manner that an edge of the local image may be detected from image data, and then 1D filtering may be performed in the direction of the detected edge.", "A plurality of sets of 1D filters may be classified into sets of sub filters, each including at least one continuous 1D filter, and then, whether the 1D filtering is to be performed in units of the sets of sub filters may be determined.", "In particular, whether all filters belonging to the same set of sub filters will perform filtering may be determined.", "Further, whether the running filtering in which 1D filtering of a current pixel is influenced by a result of 1D filtering a previous pixel is to be performed may be determined.", "In 1D filtering based on the running filtering, when a result of filtering a previous pixel is updated, a current pixel may be continuously filtered by receiving data obtained by filtering the previous pixel.", "FIG.", "17 is a block diagram of a video decoding apparatus 1500 using loop filtering performed by using the continuous 1D filtering, according to an exemplary embodiment.", "The video decoding apparatus 1500 includes a receiver 1501, an extractor 1505, and an image data decoder 1540.The extractor 1505 includes an image data obtaining unit 1510, an encoding information extractor 1520, and a loop filter coefficient information extractor 1530.The image data decoder 1540 corresponds to the image data decoder 230 included in the video decoding apparatus 200 described above with reference to FIG.", "2.The image data obtaining unit 1510 and the encoding information extractor 1520 perform some of the same operations as those of the extractor 220 of the video decoding apparatus 200.By comparison with the image data decoder 230, the image data decoder 1540 includes a loop filtering performing unit 1550 that performs loop filtering by using the continuous 1D filtering.", "According to an exemplary embodiment, the video decoding apparatus 1500 performs decoding by performing adaptive loop filtering by using the continuous 1D filtering, as will be described in detail below.", "The receiver 1501 receives and parses a bitstream which includes encoded video of a current picture, and the extractor 1505 extracts various encoded information from the parsed bitstream.", "The image data obtaining unit 1510 may obtain image data encoded in units of maximum coding units, from the parsed bitstream.", "The encoding information extractor 1520 parses the bitstream, and extracts information relating to a coded depth and an encoding mode for each of the maximum coding units, from a header of the bitstream regarding the current picture.", "The loop filter coefficient information extractor 1530 extracts filter coefficient information for performing loop filtering on the current picture.", "If loop filtering is performed by using the continuous 1D filtering, the loop filter coefficient information extractor 1530 may extract filter coefficients of each of a plurality of 1D filters.", "The loop filter coefficient information extractor 1530 may extract residual information relating to respective pairs of continuous filter coefficients of each of the plurality of 1D filters that perform the continuous 1D filtering.", "The image data decoder 1540 restores the current picture by decoding the image data encoded in units of the maximum coding units, based on the information relating to the coded depth and the encoding mode for each of the maximum coding units.", "The image data decoder 1540 may perform deblocking on data of the current picture, which has been decoded to temporal-domain image data, and perform loop filtering on the deblocked data by using the filter coefficients extracted by the loop filter coefficient information extractor 1530.Loop filtering may be separately performed on luma components and chroma components.", "If the image data decoder 1540 corresponds to the image decoder 500 of FIG.", "5, then the loop filtering performing unit 1550 of the image data decoder 1540 may correspond to the loop filtering unit 580 of the image data decoder 1540, and may perform the continuous 1D filtering on data deblocked by the deblocking unit 570.The data that was deblocked and loop-filtered may be stored in a buffer (not shown) and may be used as a reference image for compensating for a motion of a subsequent picture.", "The loop filtering performing unit 1550 successively and/or continuously performs 1D filtering in a horizontal direction and then in a vertical direction to restore the current picture.", "The loop filtering performing unit 1550 may derive a filter coefficient of each of a plurality of 1D filters, based on the residual information received from the loop filter coefficient information extractor 1530.For example, a respective current filter coefficient of each of the 1D filters may be derived by adding the difference between the respective current filter coefficient and a corresponding previous filter coefficient to the previous filter coefficient.", "The continuous 1D filtering may be performed on the deblocked data by using the respective derived filter coefficient of each of the 1D filters.", "Deblocking is performed to reduce a blocking effect occurring in decoded data, and loop filtering is performed to minimize an error between a restored image and the original image.", "Loop filtering performed by using the continuous 1D filtering performed in horizontal and vertical directions will be described in detail below.", "A current filter coefficient may be calculated by using the following equation: c[i][j]=adaptive_loop_filter_prev[i][j]+adaptive_loop_filter[i][j] (E4), wherein “i” denotes an index of each of a plurality of 1D filters, “j” denotes an index of a filter coefficient of each of the 1D filters, “c[i][j]” denotes a current filter coefficient, “adaptive_loop_filter_prev[i][j]” denotes a previous filter coefficient, and “adaptive_loop_filter[i][j]” denotes a residual component relating to a respective pair of filter coefficients that is transmitted as filter coefficient information.", "In particular, the respective current filter coefficient c[i][j] may be calculated by adding the corresponding previous filter coefficient adaptive_loop_filter_prev[i][j] and the corresponding residual component adaptive_loop_filter[i][j].", "Then, for a subsequent operation, the previous filter coefficient adaptive_loop_filter_prev[i][j] is updated to be equal to the current filter coefficient c[i][j] so as to derive a subsequent filter coefficient.", "Loop filtering performed by using the continuous 1D filtering may be performed according to Equations (E5) and (E6).", "In Equations (E5) and (E6), “i” denotes a horizontal index of a current picture and “j” denotes a vertical index of the current picture.", "qi,j=(pi,j−4*c[0][4]+pi,j−3*c[0][3]+pi,j−2*c[0][2]+pi,j−1*c[0][1]+pi,j*c[0][0]+pi,j+1*c[0][1]+pi,j+2*c[0][2]+pi,j+3*c[0][3]+pi,j+4*c[0][4]) (E5), wherein “pi,j” denotes deblocked data of the current picture, and “qi,j” denotes data obtained by performing 1D filtering on the deblocked data in a vertical direction.", "Nine pieces of data of the deblocked data may be symmetrically filtered by using five filter coefficients c[i][0] to c[i][4] of a symmetrical filter.", "fi,j=(qi,j−4*c[1][4]+qi,j−3*c[1][3]+qi,j−2*c[1][2]+qi,j−1*c[1][1]+qi,j*c[1][0]+qi,j+1*c[1][1]+qi,j+2*c[1][2]+qi,j+3*c[1][3]+qi,j+4*c[1][4]) (E6), wherein “fi,j” denotes data obtained by performing 1D filtering on the data qi,j in a vertical direction.", "Because the filter coefficient c is subject to the running filtering, 1D filtering is continuously performed on the data, which has been 1D-filtered in the horizontal direction, in the vertical direction.", "In the case of symmetrical filters, all filter coefficients of 1D filters may be set by using a lesser number of possible coefficients than a corresponding number of possible coefficients required for two-dimensional (2D) filters.", "Thus, a number of bits of information relating to filter characteristics of a set of 1D filters to be inserted into a bitstream is less than a number of bits of information relating to filter characteristics of a set of 2D filters to be inserted into a bitstream.", "Further, a capacity of memory required by the set of 1D filters for temporarily storing data during filtering is less than a corresponding capacity of memory required by the set of 2D filters for temporary storage.", "An amount of calculation which is required when filtering is performed using the set of 2D filters is far greater than a corresponding amount of calculation which is required when filtering is performed using the set of 1D filters.", "In the case of the running filtering, a plurality of filtering operations cannot be simultaneously performed when using a set of 2D filters but can be simultaneously performed when using a set of 1D filters.", "However, loop filtering according to the present disclosure is not limited to successively and/or continuously performing 1D filtering in the horizontal and vertical directions.", "According to another exemplary embodiment, loop filtering may be performed by successively and/or continuously performing filtering by using an arbitrary number of 1D filters, in arbitrary directions.", "According to an exemplary embodiment, the video decoding apparatus 1500 may receive not only filter coefficient information, but also information regarding a set of 1D filters for performing loop filtering, and thus may determine, for example, a number, types, and sizes of the set of 1D filters, quantization bits, coefficients, a filtering direction, whether filtering is to be performed, and whether the running filtering is to be performed.", "Thus, the loop filtering performing unit 1550 may perform loop filtering by using a combination of various 1D filters.", "When post-processing is performed using loop filtering, it is possible to reduce a distortion between the original image and a restored image, which may be caused when a complicated lossy compression process is performed.", "In addition, a loop-filtered image may be used as a reference image when prediction or motion compensation is performed, thereby improving image quality.", "When a combination of various types of 1D filters is used, adaptive loop filtering may be performed based on consideration of, for example, the characteristics of an image, a system environment, and/or a user demand.", "In addition, when continuous 1D filters are used instead of 2D filters, it is possible to reduce memory capacity, an amount of calculation, and a number of transmission bits, as compared with when the 2D filters are used.", "Furthermore, because a residual component relating to a respective pair of filter coefficients is encoded and transmitted, load on transmission of the filter coefficients may be reduced.", "FIG.", "18 is a flowchart which illustrates a method for performing the continuous 1D filtering, according to an exemplary embodiment.", "Loop filtering may be performed to continuously perform filtering with a plurality of 1D filters.", "In operation 1610, deblocked restored image data is received.", "In operation 1620, whether all of first through Nth filters are to be used to perform filtering is determined.", "If it is determined in operation 1620 that at least one of the first through Nth filters is not to be used, then the method proceeds to operation 1660 to store or reproduce the deblocked restored image data.", "If it is determined in operation 1620 that all of the first through Nth filters are to be used, then filtering is sequentially performed on the deblocked reproduced image data by using the first through Nth filters.", "In particular, in operation 1630, 1D filtering may be performed in a first filtering direction by using the first filter.", "In operation 1640, 1D filtering may be performed in a second filtering direction by using the second filter.", "In operation 1650, 1D filtering may be performed in an Nth filtering direction by using the Nth filter.", "In operation 1660, either the deblocked restored image data or data obtained by continuously performing 1D filtering is stored in a buffer or reproduced by a reproducing apparatus.", "FIG.", "19 is a flowchart which illustrates a method for performing the continuous 1D filtering, according to another embodiment.", "According to an exemplary embodiment, a filtering direction of a 1D filter may be determined adaptively based on the characteristics of a local image by performing an image characteristics analysis.", "For example, the filtering direction may be determined adaptively based on directions of edges of the local image in order to maintain the edges of the local image.", "In operation 1710, restored image data is received.", "In operation 1720, edge detection is performed on each of pixels of the restored image data.", "In operation 1730, 1D filtering is respectively performed on the restored image data in directions of detected edges.", "In operation 1740, data obtained by continuously performing 1D filtering on the restored image data is stored or reproduced by a reproducing apparatus.", "In a video encoding process, information relating to a set of 1D filters, which also includes filtering directions determined according to directions of edges of image data, may be encoded and provided to a decoding side.", "In a video decoding process, information relating to loop filtering may be extracted from the encoded information and may then be decoded.", "Then, 1D filtering may be performed in the filtering directions, such as edge directions of a 1D filter.", "FIG.", "20 is a flowchart which illustrates a method for encoding video by performing loop filtering by using the continuous 1D filtering, according to an exemplary embodiment.", "In operation 1810, a current picture is split into at least one maximum coding unit.", "In operation 1820, a coded depth for outputting a final coding result according to at least one split region, which is obtained by splitting a region of each of the at least one maximum coding unit according to depths, is determined by encoding the at least one split region.", "In operation 1830, image data according to a coded depth and information relating to the coded depth and an encoding mode are encoded and output according to the at least one maximum coding unit.", "In addition, filter coefficient information relating to loop filtering performed by using the continuous 1D filtering, after deblocking is performed during the encoding of the current picture, may be encoded and outputted.", "The filter coefficient information may include information regarding residual components of respective pairs of continuous filter coefficients.", "The loop filtering may be performed by successively and/or continuously performing filtering by using each of a horizontal 1D filter and a vertical 1D filter.", "In the loop filtering, 1D filters used may be symmetrical filters, and filter coefficients of the 1D filters may be determined based on the Wiener filter approach.", "FIG.", "21 is a flowchart which illustrates a method for decoding video by performing loop filtering by using the continuous 1D filtering, according to an exemplary embodiment.", "In operation 1910, a bitstream which includes encoded video is received and parsed.", "In operation 1920, encoded image data of a current picture, which has been assigned to each of at least one maximum coding unit, and information relating to a coded depth and an encoding mode of each of the at least one maximum coding unit, are extracted from the parsed bitstream.", "Filter coefficient information for performing loop filtering on the current picture may further be extracted from the parsed bitstream.", "The filter coefficient information may include information regarding a residual component of a respective pair of filter coefficients of each of 1D filters.", "The filter coefficient information may include coefficients of each of a horizontal 1D filter and a vertical 1D filter.", "In operation 1930, the image data encoded according to the at least one maximum coding unit may be decoded, based on the information relating to the coded depth and the encoding mode of each of the at least one maximum coding unit and coding unit pattern information.", "In operation 1940, deblocking is performed on the decoded image data, and loop filtering is performed on the deblocked data, by using the continuous 1D filtering.", "If the residual component of a respective pair of the filter coefficients is extracted as the filter coefficient information, the residual component may be added to a corresponding previous filter coefficient, thus deriving a current filter coefficient.", "The continuous 1D filtering may be performed using a filter coefficient thusly derived for each of the 1D filters.", "The loop filtering may be separately performed on luma components and chroma components.", "A required amount of calculation may be high when a large amount of image data or high-resolution image data is encoded or decoded in units of relatively small macroblocks.", "According to an exemplary embodiment, a coding unit selected appropriately to the size of image data is used to encode or decode the image data, and a maximum coding unit is hierarchically split into coding units, based on details of the image data.", "Based on the hierarchical coding units, a coding unit having the least coding error is determined in units of maximum coding units.", "In particular, it is possible to efficiently encode or decode the image data, based on the hierarchical coding units.", "Further, in order to reduce an amount of calculation when a large amount of image data or high-resolution image data is post-processed, loop filtering is performed after deblocking is performed, by using the continuous 1D filtering other than 2D filtering.", "Thus, both of the required amount of calculation and a number of bits of filter coefficients to be transmitted may be reduced.", "Furthermore, a residual component relating to each respective pair of the filter coefficients may be transmitted instead of the corresponding filter coefficients, thereby improving the efficiency of data transmission.", "The exemplary embodiments can be written as computer programs and can be implemented in general-use digital computers that execute the programs using a non-transitory computer readable recording medium.", "Examples of the non-transitory computer readable recording medium include magnetic storage media (e.g., read-only memory (ROM), floppy disks, hard disks, etc.)", "and optical recording media (e.g., compact disk ROMs (CD-ROMs), or digital video disks (DVDs)).", "While the present inventive concept has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present inventive concept as defined by the appended claims.", "The exemplary embodiments should be considered in a descriptive sense only and not for purposes of limitation.", "Therefore, the scope of the present disclosure is defined not by the detailed description of the exemplary embodiments but by the appended claims, and all differences within the scope will be construed as being included in the present disclosure." ] ]
Patent_15874347
[ [ "SPINAL IMPLANT DEVICE WITH BONE SCREWS", "A spinal fusion device that is expandable.", "The device features a top and bottom surface for engaging adjacent vertebrae, a hollow center for stacking of bone or bone growth material, and a slidable mechanism with grooves for expanding or unexpanding compacting the device." ], [ "1.A spinal fusion device comprising: an upper member having a top surface for contacting vertebra and outer sidewalls depending therefrom having two parallel sloped slots in a first direction; a lower member having a bottom surface for contacting vertebra and inner sidewalls depending therefrom having two parallel sloped slots in a second opposite direction than said upper member, said inner sidewalls arranged to fit inboard said outer sidewalls; a housing having a front wall, a rear wall and a first side wall forming a mirror image of a second side wall, said front wall having a centrally disposed aperture for receipt of an adjustment screw and at least one offset aperture for receipt of a bone screw, said first and second side walls including a positioning slot; an actuator having a body member with a through-hole, said body member having a first end wall with projecting first and second protruding members for slidable insertion in said first side wall slot of said housing and a second end wall with projecting first and second protruding members for slidable insertion in said second side wall slot of said housing forming a mirror image of said first slot; an adjustment screw engaging said through-hole; wherein said device is placed between adjacent vertebra with a bone screw inserted into said housing offset aperture, securing said device to the vertebra, whereby said adjustment screw is rotated to move said actuator, displacing said upper and lower members.", "2.The spinal fusion device according to claim 1, wherein said upper member and said lower member are U-shaped.", "3.The spinal fusion device according to claim 1, wherein said actuator includes a receptacle positioned around said through hole for receipt of a clip for securing said adjustment screw.", "4.The spinal fusion device according to claim 1, wherein said offset aperture is placed along a first end of said housing and a second offset aperture is placed along a second end of said housing.", "5.The spinal fusion device of claim 1, wherein said actuator protruding members engage said slots, whereby the distance between the top and bottom surfaces is adjustable as the protruding members of the actuator move within the slots, thereby moving the upper section relative to the lower section.", "6.The spinal fusion device of claim 1, wherein said first actuator protruding member is substantially diamond shaped and configured to allow a side portion of said protruding member to engage one of said sloped slots.", "7.The spinal fusion device of claim 1, wherein said first actuator protruding member is substantially diamond shaped and configured to allow an edge portion of said protruding member to engage one of said positioning slots.", "8.The spinal fusion device of claim 1, wherein said first actuator protruding member is substantially oval shaped and configured to allow a side portion of said protruding member to engage one of said sloped slots.", "9.The spinal fusion device of claim 1, wherein said first actuator protruding member substantially oval shaped and configured to allow an edge portion of said protruding member to engage one of said positioning slots.", "10.The spinal fusion device of claim 1, wherein the housing front wall aperture is constructed and arrange to allow a threaded shank of said adjustment screw to pass with a lip preventing passage of a fastener head.", "11.The spinal fusion device of claim 1, wherein the actuator protruding members slidably move in the sloped slots in a first direction when the act ator is moved and the distance between the upper and lower sections decrease, and when the actuator protruding members slidably move in the sloped slots in a second direction when the actuator is moved the distance between the upper and lower sections increase.", "12.The spinal fusion device of claim 1, wherein the housing is dimensioned to receive bone growth material.", "13.The spinal fusion device of claim 1, wherein each said bone screw includes a locking bar to prevent removal of said bone screw upon installation.", "14.The spinal fusion device of claim 13 wherein said locking bar extends across a head of each bone screw for engagement of a side surface in each said offset aperture.", "15.The spinal fusion device of claim 14, wherein each said offset aperture includes a space for receipt of said locking bar, said space formed between two alignment walls.", "16.The spinal fusion device of claim 15, wherein each said alignment wall provides directional placement of each said bone screw.", "17.The spinal fusion device of claim 13 wherein said lock bar is positioned between each said offset aperture, said lock bar rotating between an unlocked position allowing insertion of a bone screw to a locked position preventing removal of an installed bone screw." ], [ "<SOH> BACKGROUND <EOH>Spinal stabilization is one approach to alleviating chronic back pain caused by disabled disk material or excessive movement of individual vertebrae.", "Conventional stabilization techniques include fusing two or more vertebrae together to circumvent or immobilize the area of excessive movement.", "Normally, the vertebral disk material which separates the vertebrae is removed and bone graft material is inserted in the space for interbody fusion.", "In addition to, or in place of, the bone graft material, a spinal implant may be inserted in the intervertebral space.", "The conventional surgical approach for stabilization has been posteriorly for ease of access to the spine and to avoid interfering with internal organs and tissues.", "Usually the implant site is prepared to maintain natural lordosis and to accept a certain sized implant within certain pressure limits.", "This requires considerable time and skill by the surgeon." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Embodiments of the invention are directed to an expandable spinal fusion device comprising upper and lower sections with depending sidewalls forming a cube-like or rectangular structure with a hollow center.", "The upper and lower sections comprise a top and a bottom surface, respectively, for engaging adjacent vertebrae, a slidable mechanism for expanding or compacting the device, and a hollow center allowing for packing with bone graft or similar bone growth inducing material.", "The slidable mechanism comprises slots or grooves on each of the sidewalls depending from the top and bottom surfaces, and a distractor.", "The distractor comprises a rod, a body and an actuator for enabling distraction.", "The rod can be telescopic or a jack screw type rod.", "The distractor comprises a body with protruding members, rollers or pins, for engaging the grooves which are positioned in the exact location directly opposite from each other.", "When the distractor is actuated, the body slides upwards, downwards or sideways depending on the groove geometry.", "The device is inserted between the adjacent vertebrae and expanded or increased in height to engage the opposing surfaces of the adjacent vertebra.", "The adjacent vertebrae are forced apart as the height of the implant increases.", "The spinal fusion device may be used unilaterally or bilaterally.", "Accordingly, it is an objective of the instant invention to teach a posterior surgical approach for placement of an adjustable spinal implant for interbody fusion, allowing the implant to be inserted through a small incision and increased in size in situ.", "It is another objective of the instant invention to teach a spinal implant which allows the surgeon to provide for lordosis intraoperatively and to distract through the implant.", "It is yet another objective of the instant invention to teach an implant facilitating interbody fusion through bone graft or an ingrowth type implant.", "Although embodiments are directed to posterior surgical approaches and to provide for lordosis intraoperatively, it is to be understood that the invention may be employed in cervical and thoracic spinal procedures as well as from any direction, that is, anterior, posterior and lateral.", "Other objectives and advantages of this invention will become apparent from the following description taken in conjunction with the accompanying drawings wherein are set forth, by way of illustration and example, certain embodiments of this invention.", "The drawings constitute a part of this specification, include exemplary embodiments of the present invention, and illustrate various objects and features thereof." ], [ "PRIORITY CLAIM In accordance with 37 C.F.R.", "1.76, a claim of priority is included in an Application Data Sheet filed concurrently herewith.", "Accordingly, the present invention claims priority as a continuation-in-part of U.S. patent application Ser.", "No.", "15/664,891, entitled “SPINAL IMPLANT DEVICE”, filed Jul.", "31, 2017, which is a continuation-in-part of U.S. patent application Ser.", "No.", "14/642,992, entitled “SPINAL IMPLANT DEVICE”, filed Mar.", "10, 2015, now U.S. Pat.", "No.", "9,717,605, issued on Aug. 1, 2017, which is a continuation-in-part of U.S. patent application Ser.", "No.", "14/294,889, entitled “SPINAL IMPLANT DEVICE”, filed Jun.", "3, 2014, now U.S. Pat.", "No.", "9,445,920, issued on Sep. 20, 2016.The contents of the above referenced applications are incorporated herein by reference.", "FIELD OF THE INVENTION Embodiments of the invention relate to the field of orthopedic surgery, and more particularly, to implants to be placed between vertebrae in the spine.", "BACKGROUND Spinal stabilization is one approach to alleviating chronic back pain caused by disabled disk material or excessive movement of individual vertebrae.", "Conventional stabilization techniques include fusing two or more vertebrae together to circumvent or immobilize the area of excessive movement.", "Normally, the vertebral disk material which separates the vertebrae is removed and bone graft material is inserted in the space for interbody fusion.", "In addition to, or in place of, the bone graft material, a spinal implant may be inserted in the intervertebral space.", "The conventional surgical approach for stabilization has been posteriorly for ease of access to the spine and to avoid interfering with internal organs and tissues.", "Usually the implant site is prepared to maintain natural lordosis and to accept a certain sized implant within certain pressure limits.", "This requires considerable time and skill by the surgeon.", "DESCRIPTION OF THE PRIOR ART U.S. Pat.", "No.", "8,556,979, issued Oct. 15, 2013, describes an expandable fusion device capable of being installed inside an intervertebral disc space to maintain normal disc spacing and restore spinal stability.", "The fusion device includes a body portion, a first endplate, and a second endplate; both of these endplates can be moved in a direction away from the body portion or towards the body portion into an unexpanded configuration.", "SUMMARY OF THE INVENTION Embodiments of the invention are directed to an expandable spinal fusion device comprising upper and lower sections with depending sidewalls forming a cube-like or rectangular structure with a hollow center.", "The upper and lower sections comprise a top and a bottom surface, respectively, for engaging adjacent vertebrae, a slidable mechanism for expanding or compacting the device, and a hollow center allowing for packing with bone graft or similar bone growth inducing material.", "The slidable mechanism comprises slots or grooves on each of the sidewalls depending from the top and bottom surfaces, and a distractor.", "The distractor comprises a rod, a body and an actuator for enabling distraction.", "The rod can be telescopic or a jack screw type rod.", "The distractor comprises a body with protruding members, rollers or pins, for engaging the grooves which are positioned in the exact location directly opposite from each other.", "When the distractor is actuated, the body slides upwards, downwards or sideways depending on the groove geometry.", "The device is inserted between the adjacent vertebrae and expanded or increased in height to engage the opposing surfaces of the adjacent vertebra.", "The adjacent vertebrae are forced apart as the height of the implant increases.", "The spinal fusion device may be used unilaterally or bilaterally.", "Accordingly, it is an objective of the instant invention to teach a posterior surgical approach for placement of an adjustable spinal implant for interbody fusion, allowing the implant to be inserted through a small incision and increased in size in situ.", "It is another objective of the instant invention to teach a spinal implant which allows the surgeon to provide for lordosis intraoperatively and to distract through the implant.", "It is yet another objective of the instant invention to teach an implant facilitating interbody fusion through bone graft or an ingrowth type implant.", "Although embodiments are directed to posterior surgical approaches and to provide for lordosis intraoperatively, it is to be understood that the invention may be employed in cervical and thoracic spinal procedures as well as from any direction, that is, anterior, posterior and lateral.", "Other objectives and advantages of this invention will become apparent from the following description taken in conjunction with the accompanying drawings wherein are set forth, by way of illustration and example, certain embodiments of this invention.", "The drawings constitute a part of this specification, include exemplary embodiments of the present invention, and illustrate various objects and features thereof.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a perspective view of the spinal implant in a contracted position; FIG.", "2 is a side view of FIG.", "1; FIG.", "3 is a perspective view of the spinal implant in an expanded position; FIG.", "4 is a side view of FIG.", "3; FIG.", "5 is a cross sectional overlay of FIG.", "4; FIG.", "6 is a cross sectional of FIG.", "2; FIG.", "7 is a cross section of FIG.", "4; FIG.", "8 is an exploded view of the implant with an alignment pin; FIG.", "9 is an exploded view of the implant without an alignment pin; FIG.", "10 is an exploded view of an alternate embodiment of the spinal implant; FIG.", "11 is perspective view of an alternate embodiment of the spinal implant device in a contracted state; FIG.", "12 is a top view of FIG.", "11; FIG.", "13 is a side view of FIG.", "11; FIG.", "14 is a perspective view of an alternate embodiment of the spinal implant device in an expanded state; FIG.", "15 is a top view of FIG.", "14; FIG.", "16 is a side view of FIG.", "14; FIG.", "17 is an exploded view of a wedge-expansion embodiment of the spinal implant; FIG.", "18 is a perspective view of a wedge-expansion embodiment of the spinal implant device in a contracted state; FIG.", "19 is a top view of FIG.", "18; FIG.", "20 is a side view of FIG.", "18; FIG.", "21 is a perspective view of a wedge-expansion embodiment of the spinal implant device in an expanded state; FIG.", "22 is a top view of FIG.", "21; FIG.", "23 is a side view of FIG.", "21; FIG.", "24 is a rear view of FIG.", "18; FIG.", "25 is an exploded view of a curved-expansion embodiment of the spinal implant device; FIG.", "26 is a perspective view of a curved-expansion embodiment of the spinal implant device in a contracted state; FIG.", "27 is a top view of FIG.", "26; FIG.", "28 is a side view of FIG.", "26; FIG.", "29 is a perspective view of the curved-expansion embodiment of the spinal implant device in an expanded state; FIG.", "30 is a top view of FIG.", "29; FIG.", "31 is a side view of FIG.", "29; FIG.", "32 is a perspective view of another embodiment of the spinal implant using pedicle screws for securement; FIG.", "33 is a side view thereof; FIG.", "34 is a perspective view of the spinal implant illustrating expansion; FIG.", "35 is a side view of FIG.", "34; FIG.", "36 is an exploded view thereof; FIG.", "37 is a perspective view of an alternative screw locking embodiment of the spinal implant in an unlocked position; FIG.", "38 is a perspective view of FIG.", "37 of the alternative screw locking embodiment in a locked position; and FIG.", "39 is an exploded view of the alternative screw locking embodiment.", "DETAILED DESCRIPTION The following description of the preferred embodiments is merely exemplary in nature and is in no way intended to limit the invention, its application or uses.", "It should be understood that numerous specific details, relationships, and methods are set forth to provide a full understanding of the invention.", "One having ordinary skill in the relevant art, however, will readily recognize that the invention can be practiced without one or more of the specific details or with other methods.", "The present invention is not limited by the illustrated ordering of acts or events, as some acts may occur in different orders and/or concurrently with other acts or events.", "Furthermore, not all illustrated acts or events are required to implement a methodology in accordance with the present invention.", "Embodiments of the invention may be practiced without the theoretical aspects presented.", "Moreover, the theoretical aspects are presented with the understanding that Applicants do not seek to be bound by the theory presented.", "Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.", "It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.", "As used herein, the singular forms “a”, “an” and “the” are intended to include the plural forms as well, unless the context clearly indicates otherwise.", "Furthermore, to the extent that the terms “including”, “includes”, “having”, “has”, “with”, or variants thereof are used in either the detailed description and/or the claims, such terms are intended to be inclusive in a manner similar to the term “comprising.” A spinal fusion is typically employed to eliminate pain caused by the motion of degenerated disk material.", "Upon successful fusion, a fusion device becomes permanently fixed within the intervertebral disc space.", "Referring now to the Figures, the spinal fusion device 10 is inserted into the intervertebral space in the insertion mode to replace damaged, missing or excised disk material.", "In an exemplary embodiment, the device 10 comprises an upper section 11, a top surface 12, a lower section 13, a bottom surface 14, a body portion 18 and a distractor 55.The device may be made of conventional materials used for surgical implants, such as stainless steel and its many different alloys, titanium, titanium alloys, metallic alloys, polymeric materials, plastics, plastic composites, ceramic and any other metal or material with the requisite strength and biologically inert properties.", "In one embodiment, the upper section 11 of the device 10 comprises a top surface 12 for engaging the end plate of a vertebra and the lower section 13 comprises a bottom surface 14 for engaging the end plate of adjacent vertebra.", "The top surface 12 and bottom surface 14 are planar to provide large contact areas with each vertebra.", "The to and bottom surfaces 12 and 14 each end at one end with a sloping or angled edge 15, 16 running the width of the top 12 and bottom 14 surfaces, respectively.", "The top surface ends with an edge 15 sloped towards the bottom surface, and the bottom surface comprises an edge 16 sloped towards the top surface.", "In other embodiments, only the top surface has a sloped edge.", "In another embodiment, only the bottom surface has a sloped edge.", "In yet other embodiments, the top and bottom surfaces lack a sloped edge.", "The device 10 is hollow, allowing for insertion of bone graft, bone graft material, scaffolds or any tissue or cellular material.", "In one embodiment, bone graft or similar bone growth inducing material can be introduced around and within the fusion device to further promote and facilitate bone fusion.", "The fusion device is hollow in the center, further providing a space for packing with bone graft or similar bone growth inducing material.", "Such bone graft or bone growth inducing material can be packed, prior to, subsequent to, or during implantation of the fusion device.", "The device 10 has two extreme positions and is adjustable infinitely between these positions.", "The expanded position 100 is the sum of the height of the upper section 11 and the lower section 13.The compact position 101 is the height of the sides 21 or 22 of the body portion and the sum of the thickness of the top surface 12 and bottom surface 14.The top surface 12 and the bottom surface 14 contact the body port ion 18 when the device is in a compact or unexpanded position with the upper section sidewalls 23, 24 being able to slidably fit into the hollow area.", "It is to be understood that the placing of the sidewalls of the upper and lower sections is interchangeable, in that the sidewalls of the lower section can be placed, at a distance further apart than the sidewalls of the upper section.", "In this embodiment, the upper section sidewalls slide down the inner sidewalls of the lower section sidewalls.", "Conversely, the upper section sidewalls can be placed at a wider distance than the lower section sidewalls so that the upper section sidewalls slide over the lower section sidewalls during the extension or when the device is in a compacted position.", "In another embodiment, the upper and lower section sidewalls are placed equidistant from each other so that the sidewalls rest upon each other when the device is in the unexpanded or compact position.", "The device can be rotated along the longitudinal axis 180 degrees so that the upper section becomes the lower section and vice versa.", "The upper section 11 comprises a top surface 12 with a large aperture 20 to facilitate bon ingrowth after implantation, and opposing depending sidewalls 23 and 24 projecting from the top surface 12 and positioned parallel to each other.", "The depending sidewalls 23, 24 terminate in a flat plane, and each sidewall possesses at least one slot or groove 70 for engaging a protruding member, rollers or pins 52 of the distractor body 55; the protruding member 52 dimensioned to slidably fit in the slots or grooves 70.The angle of the slot or groove relative to a 900 angle to the horizontal plane of the upper section 11 can vary so that the maximum expanded position 100 can be increased or decreased.", "For example, with the groove close to vertical at a 90° angle to the horizontal plane, the maximum expanded position will be greater than if the slot or groove is at a 45° angle relative to the horizontal plane.", "However, it is to be understood that a slot or groove having, for example, a 45° angle to the horizontal plane would not only expand the upper section 11 vertically, but also displace the distractor 55 horizontally.", "The slot or groove 70 engages the protruding members 52 of the distractor 55 to guide the relative movement of the upper section 11, maintaining the distractor 55 and the depending sidewalls 23, 24 in alignment.", "The bottom surface 14 of the lower section 13 has a large aperture 20 to facilitate bone ingrowth after implantation.", "The lower section 13 comprises opposing upstanding sidewalls 40, 41 projecting from the bottom surface 14 and positioned parallel to each other.", "The distance between the opposing sidewalls 40, 41 is dimensioned to be less than the distance between the opposing sidewalls 23 and 24 of the upper section 11 so that the upper and lower sections can slidably move between the expanded and compact positions of the device.", "The depending sidewalls 40 and 41 terminate in a flat plane, and each sidewall possesses at least one slot or groove 71 for engaging protruding members 52 of the distractor 55, dimensioned to slidably fit in the slots or grooves 71.The protruding member 52 can be any type, size or shape, for example, rollers, pins, as long as these protruding members 52 can be engaged by the slots or grooves 71.The angle of the slots or grooves 71 of the lower depending sidewalls 40 and 41 relative to the angle of the slots or grooves 70 of the upper depending sidewalls 23 and 24 is greater than 0° and u to 180°.", "The slots or grooves 70, 71 engage the protruding members, rollers or pins 52 of the distractor 55 to guide the relative movement of the upper and lower sections 11, 13, maintaining the distractor 55 and the depending sidewalls in alignment.", "The slots or grooves 70, 71 on each opposing sidewall are diametrically opposed on the opposite sidewalls.", "The depending sidewalls of the upper and lower sections and the slot or groove of each sidewall are smooth to provide ease in the relative sliding contact between the sidewalls and between the protruding members 52 of the distractor 55.In alternative embodiments, the slots or grooves 70, 71 may comprise jagged steps which are positioned to provide a lock-step expansion when the device is expanded.", "In a first embodiment, depicted in FIGS.", "1-9, the device 10 comprises a body portion 18, upper and lower sections 11, 13, a distractor 55, and an actuation member 51.The body portion 18 has a first end 17, a second end.", "19, a first side portion 26 connecting the first end 17 and the second end.", "19, and a second side portion 27 connecting the first end 17 and the second end 19.The first end 17 of the fusion device 10 includes at least one angled surface, a grooved end and a flat end or planar end plate.", "The first end 17 comprises multiple angled surfaces.", "There are at least two opposing angled surfaces 30, 31 forming a generally wedge-shape.", "In other embodiments, there are at least two opposing angled surfaces 30, 31 and a flat end or planar end plate 32, wherein the angled surfaces do not meet but culminate at the flat end 32 at a first end 17, forming a generally wedge-shape; and at the opposing end, the angled surfaces culminate to form a receptacle for receiving the sloped edges of the top and bottom surfaces when the device is in a compacted or unexpanded form.", "In one embodiment, the top edge 15 and the bottom edge 16 are angled so as to run parallel with the angled surfaces 30 of the first end 17.The second end 19 includes an opening 60 which may include threading.", "The opening 60 is dimensioned to fit a distractor 55.In one exemplary embodiment, the distractor 55 comprises an actuation member 51, a rod 54 and a distractor body 55.The actuation member 51 is located on the outer surface of the second end 19, and a member 53 of the second end 19 aligns the rod 54 with the distractor body 55.The rod 54, which extends into the hollow area of the distractor body 55, may be threaded or telescopic for slidably moving the distractor body 55 within the hollow center of the device 10.Although the term “rod’ is used, it is merely descriptive and encompasses any shape or form as long as it can move the body of the distractor.", "In this embodiment, the distractor body 55 is dimensioned to fit in the hollow center of the device and to provide a large volume for the placing of bone graft, bone graft inducing material, scaffolds or any tissue or cellular material.", "In this embodiment, the rod 54 is attached to the distractor body 55.The distractor body 55 comprises a first end 80, a second end 81, a first side portion 82 connecting the first end 80 to the second end 81, and a second side portion 83 connecting the first end 80 to the second end 81.The first side portion 82 and the second side portion 83 each comprise at least one, but preferably two protruding members, rollers or pins 52 which are dimensioned to slidably fit into the grooves or slots 70, 71 in the sidewalls of the upper and lower sections.", "The first end 80, in exemplary embodiments, is a planar surface.", "In some embodiments, an alignment pin 84 is attached at the center of the planar surface of the first end 80.The alignment pin 84 may be hollow and threaded, or may be hollow and smooth, and dimensioned for insertion into support aperture 79.In some embodiments, the rod 54 is a jack screw for engagement of a threaded bore 85 at the second end.", "81 of the distractor body 55.A bracket 86 is attached to the second end 19 of the body portion 18.In one embodiment, the bracket 86 comprises a bore 87 which has a larger countersunk bore 88 for receiving the rod 54.The bore 87 and countersunk bore 88 are aligned with the bore 85 of the distractor body 55.As illustrated in FIG.", "9, the alignment pin can be removed and still provide stability to the distractor.", "The distance between the top surface 12 and the bottom surface 14 is adjustable by moving the upper section 11 relative to the lower section 13.The protruding members 52 of the distractor 55 slide downwards when the distractor is actuated and the distance between the upper and lower section decreases.", "Conversely, the protruding members 52 of the distractor slide upwards when the distractor is actuated and the distance between the upper 11 and lower section 13 increases.", "The distractor 55 can be a telescopic mechanism, whereby the distractor comprises a member, for example, a telescopic rod, for moving the distractor body 55 by a sliding mechanism and, optionally, a locking mechanism to lock the distractor at a desired position.", "The distractor 55 is not limited to a sliding mechanism, but can utilize any mechanism as long as the distractor can cause the distractor body 55 to move.", "The device 10 is inserted into the disk space between adjacent vertebrae with the top surface 12 in contact with the end plate of one vertebra and the bottom surface in contact with the end plate of the adjacent vertebra.", "When the surgeon actuates the distractor, the rod 54 is extended into the cavity, pushing the distractor body 55 and the protruding members 52 to slide along the slots or grooves 70, 71, thereby changing the distance between the top and bottom surfaces 12, 14 as the sidewalls move apart, thereby expanding the device 10.When the actuator 51 is actuated in the opposite direction, the rod member 54 retracts, pulling the distractor body 55 towards the end of the outer wall to which the distractor 55 is fastened.", "The extending of the rod member 54 can be accomplished by a variety of means, including a pushing or pulling mechanism or a rotating mechanism utilizing a screw and thread means.", "The telescopic rod, in this embodiment, comprises one or more rods of equal and/or varying lengths, each rod having a circumference slightly smaller than the previous rod so that, when the actuator is actuated, the rods can extend beyond the length of the first rod or retract into each other.", "The embodiment depicted in FIGS.", "10-16 includes a top surface 12 and bottom surface 14 which are constructed with friction teeth 33 for better engagement with the vertebrae.", "These friction teeth 33 are angled to allow the device 10 to be inserted with a lower resistance, but provide an increased resistance to the device 10 being retracted.", "This provides for increased stability of the device 10 between adjacent vertebrae.", "Additionally, the friction teeth 33 are sloped or angled on the outer edge 36, as any sharp corner edge can make insertion or proper positioning of the device 10 more difficult.", "FIG.", "10 is an exploded view of a preferred embodiment of the present invention.", "It has the same basic structure as the other embodiments of the device 10, having an upper section 11 with a top surface 12 and two opposing sidewalls 23, 24 extending inward and terminating at a plane having slots or grooves 70 to engage with the protruding members 52 of the distractor 55.The top surface 12 has an aperture 20 allowing for a channel to the hollow of the device.", "There is a sloping or angled leading edge 15 which abuts the first end 17 of the body portion 18 in a compact position 101.The lower section 13 is constructed to cooperate with the upper section 11, having a bottom surface 14 and two opposing sidewalls 40, 41 extending inward and terminating at a plane having slots or grooves 71 to engage with the protruding members 52 of the distractor 55.The bottom surface 14 has an aperture 20, allowing for a channel to the hollow of the device.", "There is a sloping or angled leading edge 16 which abuts the first end 17 of the body portion 18 in a compact position 101.In the preferred embodiment, the body portion 18 has apertures 28, 29 on opposing sidewalls 26, 27 which act as channels for the protruding members 52 of the distractor 55, which allow the distractor 55 to move along the longitudinal axis of the body portion 18.The opening 60 of the second end 19 of the body portion is enlarged in the preferred embodiment, allowing passage of an actuation member 51 and spacer 50 there through.", "The actuation member rod 54 cooperates with the support aperture 79 on the first end 17 of the body portion 18, wherein actuation moves the distractor 55 along the longitudinal axis of the body portion 18 towards the first end 17.The distractor 55 in the preferred embodiment has a larger opening 89 on its second end 81, corresponding to the size of opening 60.Openings 60 and 89 create a passage to the hollow, whereby bone graft or similar bone growth material can be inserted into the device 10 and contact the vertebrae on the upper and lower sides of the device 10.As depicted in FIGS.", "11-13, when the device 10 is in a contracted state, the distractor 55 is back towards the second end 19.The actuation member 51 passes through an opening in the distractor first end 80, then through the spacer 50, and then enters the support aperture 79.The rod 54 of the actuation member 51 is shown here as a jack screw for engagement with the support aperture 79, which includes a bore for receiving the rod 54.The bore is aligned with the opening on the distractor first end 80.The device is inserted into the disk space between adjacent vertebrae with the top surface 12 in contact with the end plate of one vertebra and the bottom surface 14 in contact with the end plate of the adjacent vertebra.", "When the surgeon actuates the distractor 55, the rod 54 is extended into the support aperture 79, pulling the distractor body 55 and the protruding members 52 to slide along the slots or grooves 70, 71 towards the body portion first end 17, thereby changing the distance between the top and bottom surfaces 12, 14 as the sidewalls move apart, thereby expanding the device 10.When the actuator 51 is actuated in the opposite direction, the rod member 54 retracts, pushing the distractor body 55 towards the second end 19, and thereby contracting the device.", "Actuation of the actuation member 51 causes the distractor 55 to move along the longitudinal axis of the body portion 18, guided linearly by the protruding members 52 within apertures 28, 29 of the body portion.", "This movement along the longitudinal axis of the body portion 18, causes the protruding members 52 to engage with the slots or grooves 70, 71.As the distractor 55 moves from the second end 19 to the first end 17 of the body portion 18, the upper section 11 and lower section 13 are forced apart, moving perpendicular to the longitudinal axis of the body portion.", "The extending of the rod member 54 can be accomplished by a variety of means, including a pushing or pulling mechanism, or a rotating mechanism utilizing a screw and thread means.", "The telescopic rod, in this embodiment, comprises one or more rods of equal and/or varying lengths, each rod having a circumference slightly smaller than the previous rod so that, when the actuator is actuated, the rods can extend beyond the length of the first rod or retract into each other.", "Passage of an instrument through openings 60 and 89 allows a surgeon to actuate the actuation member 51.FIGS.", "14-16 show the expanded state of the device 10.In an expanded state, the friction teeth 33 engage with the adjacent vertebrae to prevent movement of the device 10, now set in place.", "Once the device 10 is properly positioned, the tool used for actuation can be removed, and bone graft or bone growth material can be inserted through openings 60 and 89, where it fills in the hollow of the device and flows outward to the vertebrae through openings in the top surface 12 and the bottom surface 14.FIGS.", "17-24 depict an alternate embodiment of the spinal implant device 10 which expands unevenly, forming a substantially wedge shape upon expansion.", "In this embodiment, the second end 19 further comprises two sets of opposing angled surfaces 34, 35, where surfaces 35 contain side opening 61 to further be able to disperse bone growth material injected into the hollow of the device 10 after insertion.", "In this embodiment, a first slot or groove 67 is positioned towards the first end 17 of the device, and a second slot or groove 67 is positioned towards the second end 19 of the device.", "The second slot or groove 67 has a first region 68 and a second region 69, whereby the slot or groove 67 forms a shallower angle with respect to the longitudinal axis than slot or groove 66.Second region 69 is a radius, and first region 68 is a slot.", "Upon actuation of the actuation member 51, the distractor 55 moves along the longitudinal axis of the device 10 from the second end 19 towards the first end 17.The causes the protruding members 52 to slidably move through the slots or grooves 66, 67 until the distractor ultimately reaches the first end 17, separated by spacer 50.A second spacer 49 rests between the head of the actuation member 51 and the distractor 55.Because of the differing angles of slot or groove 66 and 67 with respect to the longitudinal axis, slot or groove 66 causes the upper section 11 and lower section 13 to expand at a greater rate and to a greater degree than the upper section 11 and lower section 13 at the second end, which is being expanded by slot or groove 68 which has a shallower angle with respect to the longitudinal.", "This uneven expansion between the upper section 11 and lower section 13 at the first end 17, as compared to the second end 13, causes the device 10 in an expanded state 100 to form a substantially wedge-shape, as depicted in FIGS.", "21-23.This uneven spacing allows the device to more securely lodge into a space between vertebrae where, once the device is inserted, actuation can allow the device to expand to fill an angled gap between vertebrae, and can position vertebrae based on the amount of actuation of the actuation member 51.FIGS.", "25-31 depict a further alternate embodiment of the spinal implant device 10.In this device, the top surface 12 and the bottom surface 14 are curved about focal points within the body of the spinal implant device.", "In this embodiment, the slots or grooves 70, 71 are parallel, as in the other embodiments.", "However, the top surface 12 and bottom surface 14 are curved about a focus in the center of the device.", "The expansion between the upper section 11 and lower section 13 is even because of the parallel slots or grooves, but because of the curved shape of the upper and lower surfaces 12, 14, the device has non-uniform spacing between the upper and lower sections 12, 14, between the first end 17 and the second end 19.Additionally, the friction teeth 33 have a first sloping region 37 and a second sloping region 38 adding to the curvature on the top surface 12 between the sidewall s 23, 24 and the bottom surface 14 between the sidewalls 40, 41.This irregular spacing allows the device to more securely fit into a space between vertebrae where the bones have a similar irregular shape, such as in a cavity.", "Referring now to FIGS.", "32-36, illustrated is an embodiment securable to the vertebra with bone screw fasteners.", "In this embodiment, the spinal fusion device 150 comprises a U-shaped upper member 152 having a top surface 154 for contacting vertebra.", "The top surface 154 can be smooth or include teeth 156.The teeth 156 can be sloped for ease of insertion and inhibiting removal.", "The upper member 152 includes a first outer sidewall 158 depending from the top surface 154.The first outer sidewall 158 includes two parallel sloped slots 160, 162 formed in a first direction, wherein an upper portion 164 and 166 are positioned away from a bridge 168 that forms part of the U-shaped upper member 152.The upper member 152 includes a second outer sidewall 178 depending from the top surface 154.The second outer sidewall 178 includes two parallel sloped slots 180, 182 formed in a first direction, wherein an upper portion 184 and 186 are positioned away from the bridge 168, wherein the second outer sidewall 178 forms a mirror image of the first outer sidewall 158.A U-shaped lower member 202 having a bottom surface 204 for contacting vertebra.", "The bottom surface 204 can be smooth or include teeth 206.The teeth 206 can be sloped for ease of insertion and inhibiting removal.", "The lower member 202 includes a first inner sidewall 208 depending from the bottom surface 204.The first inner sidewall 208 includes two parallel sloped slots 210, 212 formed in a first direction, wherein a lower portion 214 and 216 are positioned away from a bridge 218 that forms part of the U-shaped lower member 202.The lower member 202 includes a second inner sidewall 228 depending from the bottom surface 204.The second inner sidewall 228 includes two parallel sloped slots 230, 232 formed in a first direction, wherein an upper portion 234 and 236 are positioned away from the bridge 218, wherein the second inner sidewall 228 forms a mirror image of the first inner sidewall 208.The first and second inner sidewall 208, 228 are constructed and arrange to fit inboard the first and second outer sidewalls 158, 178.The first and second outer sidewalls 158, 178 fit within a housing 250 having an inner surface 252 and an outer surface 254 formed by a front wall 256, a rear wall 260, a first side wall 258, and a second side wall 262.The first side wall 258 includes a positioning slot 270 forming a mirror image of positioning slot 272 formed in the second side wall 262.Each positioning slot 270 and 272 includes a frontal lobe 274 having an elongated flat section and a rear lobe 276 which lacks a flat section.", "The front wall 256 has a centrally disposed aperture 290 for receipt of an adjustment screw 300 and spacer ring 311.The adjustment screw 300 has a head 302 for ease of rotation using a driver, not shown, with the head 302 having a diameter larger than the diameter of the threaded shank 304.A lip section 306 is sized for rotation within the aperture 290 upon engagement of clip 482.The threaded shank 304 engages threaded aperture 253 formed in the rear wall 260 of the housing 250.A first offset aperture 310 for receipt of a bone screw 400 is formed along one side of the aperture 290, and a second offset aperture 312 is formed along the opposite side of the aperture 290 for receipt of a bone screw 410.Bone screw 400 is defined by a threaded shank 402 and drive head 404.The drive head 404 includes an aperture 406 extending across the diameter of the drive head 404 for receipt of lock bar 408.Similarly, bone screw 410 is defined by a threaded shank 412 and drive head 414.The drive head 414 includes an aperture 416 extending across the diameter of the drive head 414 for receipt of lock bar 418.Each offset aperture 310, 312 includes a space 401 formed between alignment walls 403 that provide directional placement of each said bone screw.", "The space 401 captures the ends of each lock bar 408, 418 upon installation of the bone screw.", "An actuator 450 has a body member 452 with a through-hole 454; the body member 452 having a first end wall 456 with projecting first protruding member 460 and second protruding member 462 for slidable insertion in the first side wall slot 270 of the housing 250, and a second end wall 466 with projecting first pin member 468 and second protruding member 470 for slidable insertion in said second side wall slot 272 of the housing 250.The actuator 450 includes a receptacle 480 positioned on opposing side edges of the through-hole 454 for receipt of a clip 482 for securing said adjustment screw 300 to the actuator 450.The clip 482 is generally U-shaped with tabs 484 and 486 to engage an upper surface 488 of the actuator 450 to maintain positioning of the clip 482 once installed.", "Referring to FIGS.", "32 and 33, the spinal implant device 150 is illustrated in a non-expanded position with upper member 152 and lower member 202 placed against housing 250.The positioning slot 272 formed in the second side wall 262 has a frontal lobe 274 having an elongated flat section #?", "and a rear lobe 276.Protruding member 468 is depicted closer to the front wall 256, and protruding member 470 is positioned near the center of the slot 272.As depicted in FIGS.", "34 and 35, the spinal implant device 150 is illustrated in an expanded position with upper member 152 and lower member 202 extended apart from the housing 250.The positioning slot 272 formed in the second side wall 262 depicts the protruding member 468, which is substantially diamond shaped, moved away from the front wall 256.Protruding member 470, which is substantially oval shaped, is positioned near the rear wall 260 center of the slot 272.In operation, the device 150 is placed between adjacent vertebra with bone screws 400 and 410 inserted into the housing offset aperture 310, 312, securing the device to the vertebra.", "The adjustment screw 300 is rotated to move the actuator, displacing the upper member 152 and lower member 202.The actuator protruding members 460, 462, 468, 470 slidably move in the sloped slots in a first direction when the actuator is moved and the distance between the upper and lower sections decrease, and when the actuator protruding members slidably move in the sloped slots in a second direction when the actuator is moved and the distance between the upper and lower sections increase.", "The housing 250 is dimensioned to receive bone growth material.", "Referring now to FIGS.", "37-39, illustrated is an alternative embodiment having a single lock bar.", "In this embodiment, the spinal fusion device 550 comprises a U-shaped upper member 552 and lower member 554 having the exact same elements as the previous embodiment having upper member 152 and lower member 202.In this alternative embodiment, front wall 556 has a centrally disposed aperture 558 for receipt of an adjustment screw 560.The adjustment screw 560 has a socket 562 for ease of rotation using a driver, not shown.", "A lip section 564 is sized for rotation within the aperture 558 and a threaded shank 566 engages threaded aperture 568 formed in the rear wall of the housing 570.The adjustment screw 560 operates in conjunction with the actuator 580.A first offset aperture 572 for receipt of a bone screw 400 is formed along one side of the aperture 558, and a second offset aperture 574 is formed along the opposite side of the aperture 558 for receipt of a bone screw 410.A lock bar 590 is securable to the housing 570 through the aperture 558 using a c-clip 592 to engage a lip 594 of the lock bar 590 portion that is inserted through the aperture 558.The lock bar 590 has a pair of ends 596 and 598 rotating between an unlocked position as depicted in FIG.", "37 allow insertion of bone screws 400 and 410.Once the bone screws are installed, the lock bar 590 is rotated by engagement of socket 600 preventing removal of the installed bone screws 400 and 410.The invention has been described in detail with reference to preferred embodiments thereof.", "However, it will be appreciated that those skilled in the art, upon consideration of this disclosure, may make modifications and improvements within the spirit and scope of the invention.", "The following non-limiting examples are illustrative of the invention.", "All documents mentioned herein are incorporated herein by reference.", "All publications and patent documents cited in this application are incorporated by reference for all purposes to the same extent as if each individual publication or patent document were so individually denoted.", "By their citation of various references in this document, Applicants do not admit any particular reference is “prior art” to their invention." ] ]
Patent_15874351
[ [ "CONTINGENT ACQUISITION AND ANALYSIS OF BIOLOGICAL SIGNAL OR FEATURE THEREOF FOR EPILEPTIC EVENT DETECTION", "We report a method comprising receiving a first indication to gather a first biological signal or feature thereof from a patient; gathering the first biological signal or feature thereof; receiving a second indication to stop gathering the first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping gathering the first biological signal or feature thereof.", "We also report a medical device system configured to implement the method.", "We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method." ], [ "1.A method, comprising: receiving a first indication to acquire a first biological signal or feature thereof from a patient; acquiring the first biological signal or feature thereof; receiving a second indication to stop acquiring the first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping acquisition of the first biological signal or feature thereof.", "2.The method of claim 1, wherein at least one of the first indication or the second indication is based at least in part on at least one second biological signal or feature thereof from the patient.", "3.The method of claim 2, wherein the second biological signal or feature thereof is selected from an electrocardiography (EKG) signal or feature thereof or a kinetic signal or feature thereof, and the first biological signal or feature thereof is selected from the EKG signal or feature thereof and kinetic signal or feature thereof, an electroencephalography (EEG) signal or feature thereof, an electrocorticography (ECoG) signal or feature thereof, a reaction time signal or feature thereof, an awareness signal or feature thereof, or a responsiveness signal or feature thereof.", "4.The method of claim 3, wherein the first indication is an indication of an occurrence of a seizure based on the EKG signal or feature thereof, and the second indication is of an end of the seizure based on the EKG signal or feature thereof.", "5.The method of claim 2, wherein the second biological signal or feature thereof is selected from an electrocardiography (EKG) signal or feature thereof or a kinetic signal or feature thereof, and the first biological signal or feature thereof is selected from the EKG signal or feature thereof and kinetic signal or feature thereof which is not selected for the second biological signal or feature thereof, an electroencephalography (EEG) signal or feature thereof, an electrocorticography (ECoG) signal or feature thereof, a reaction time signal or feature thereof, an awareness signal or feature thereof, or a responsiveness signal or feature thereof.", "6.The method of claim 2, wherein the second biological signal or feature thereof is selected from at least one of a cardiac signal or feature thereof, a kinetic signal or feature thereof, or a respiratory signal or feature thereof; the first biological signal or feature thereof is selected from at least one of the cardiac signal or feature thereof, the kinetic signal or feature thereof, and the respiratory signal or feature thereof, provided the first biological signal or feature thereof is different from the second biological signal or feature thereof the first indication is based at least in part on the second biological signal or feature thereof and the first indication is indicative of an epileptic event.", "7.The method of claim 6, wherein the first biological signal or feature thereof is a heart rate, a heart rate variability, an EKG morphology, or a PKG morphology, and the second biological signal or feature thereof is a different one of the heart rate, the heart rate variability, the EKG morphology, or the PKG morphology.", "8.The method of claim 2, wherein the second biological signal or feature thereof is a cortical brain signal or feature thereof and the first biological signal or feature thereof is an electrocardiography (EKG) signal or feature thereof, a respiratory signal or feature thereof, a kinetic signal or feature thereof, a reaction time signal or feature thereof, an awareness signal or feature thereof, or a responsiveness signal or feature thereof.", "9.The method of claim 1, wherein at least one of the first indication or the second indication is based at least in part on at least one exosomatic signal or feature thereof.", "10.The method of claim 1, wherein the first indication is based at least in part on a first feature of the first biological signal or feature thereof, and the second indication is based at least in part on a second feature of a second biological signal or feature thereof.", "11.The method of claim 1, wherein the first biological signal or feature thereof is selected from an autonomic signal or feature thereof, a neurologic signal or feature thereof, a metabolic signal or feature thereof, an endocrine signal or feature thereof, or a tissue stress marker signal or feature thereof.", "12.The method of claim 11, wherein the at least one exosomatic signal or feature thereof is a time of day signal or feature thereof, a time of month signal or feature thereof, a luminance level signal or feature thereof, an acoustic noise level signal or feature thereof, a temperature signal or feature thereof, a barometric pressure signal or feature thereof, a signal or feature thereof indicative of a physical activity of the patient and when it was performed by the patient, a signal or feature thereof indicative of an attention level of the patient and when the patient was attentive, a signal or feature thereof indicative of a cognitive activity of the patient, a type of cognitive activity and when the cognitive activity was performed by the patient, a signal or feature thereof indicative of a time elapsed since a last seizure of the patient, a last seizure type or class, a last seizure severity of the patient, a signal or feature thereof indicative of a time elapsed since a delivery of a therapy to the patient, a type of the therapy, a therapy dosage or therapy parameters, an efficacy of the therapy, an adverse effects of the therapy, an adverse effect type, an adverse effect severity, or a signal or feature thereof indicative of a time elapsed since a last caloric intake and a last caloric intake amount, a signal or feature thereof indicative of a stress level and a stress level change for the patient.", "13.A method, comprising: gathering a first biological signal or feature thereof from a patient; receiving an indication to gather a second biological signal or feature thereof from the patient; gathering the second biological signal or feature thereof; determining at least one of a sensitivity, a specificity, or a speed of detection of a pathological state in the patient from both the first biological signal or feature thereof and the second biological signal or feature thereof; continuing gathering of the biological signal or feature thereof having a better sensitivity of detection, a better specificity of detection, or a better speed of detection; and stopping gathering of biological signals or features thereof having a poorer sensitivity of detection, a poorer specificity of detection, or a poorer speed of detection.", "14.A method, comprising: gathering a first biological signal or feature thereof from a patient; receiving an indication to gather a second biological signal or feature thereof from the patient; gathering the second biological signal or feature thereof; and determining at least one of a sensitivity, a specificity, or a speed of detection of a pathological state in the patient from both the first biological signal or feature thereof and the second biological signal or feature thereof.", "15.The method of claim 14, further comprising: determining at least one of a first sensitivity of detection for the first biological signal, a first specificity of detection for the first biological signal, and a first speed of detection for the first biological signal.", "16.The method of claim 15, further comprising: comparing at least one of the first sensitivity of detection for the first biological signal, the first specificity of detection for the first biological signal, and the first speed of detection for the first biological signal to at least one of a sensitivity of detection threshold, a specificity of detection threshold, and a speed of detection threshold; and discontinuing gathering the first biological signal of feature thereof from the patient based on the comparison.", "17.The method of claim 15, further comprising: determining at least one of a second sensitivity of detection for the second biological signal, a second specificity of detection for the second biological signal, and a second speed of detection for the second biological signal.", "18.The method of claim 17, further comprising: comparing at least one of the second sensitivity of detection for the second biological signal, the second specificity of detection for the second biological signal, and the second speed of detection for the second biological signal to at least one of a sensitivity of detection threshold, a specificity of detection threshold, and a speed of detection threshold; discontinuing gathering the second biological signal of feature thereof from the patient based on the comparison 19.The method of claim 15, further comprising: determining at least one of a second sensitivity of detection for the second biological signal, a second specificity of detection for the second biological signal, and a second speed of detection for the second biological signal; determining a first comparison based on comparing at least one of the first sensitivity of detection for the first biological signal, the first specificity of detection for the first biological signal, and the first speed of detection for the first biological signal to at least one of a sensitivity of detection threshold, a specificity of detection threshold, and a speed of detection threshold; determining a second comparison based on comparing at least one of the second sensitivity of detection for the second biological signal, the second specificity of detection for the second biological signal, and the second speed of detection for the second biological signal to at least one of the sensitivity of detection threshold, the specificity of detection threshold, and the speed of detection threshold.", "20.The method of claim 19, further comprising: discontinuing gathering the first biological signal of feature thereof from the patient based on the first comparison; and discontinuing gathering the second biological signal of feature thereof from the patient based on the second comparison." ], [ "<SOH> FIELD OF THE INVENTION <EOH>This disclosure relates to medical device systems and methods capable of detecting epileptic seizures." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>In some embodiments, the present disclosure relates to a method, comprising: receiving a first indication to gather a first biological signal or feature thereof from a patient; gathering the first biological signal or feature thereof; receiving a second indication to stop gathering the first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping gathering the first biological signal or feature thereof.", "In some embodiments, the present disclosure relates to a method, comprising: sensing a first biological signal or feature thereof with a first sensor; recording the first biological signal or feature thereof; sensing a second biological signal or feature thereof with a second sensor; recording the second biological signal or feature thereof; buffering the second biological signal or feature thereof to a memory buffer; analyzing the first biological signal or feature thereof to determine at least one feature; detecting a brain state change based on the at least one feature of the first biological signal or feature thereof; initiating analysis of the second biological signal or feature thereof in response to detecting the brain state change; confirming or not confirming the brain state change based on the analysis of the second biological signal or feature thereof; detecting an end of the brain state change based on at least one of the first biological signal or feature thereof or the second biological signal or feature thereof; and stopping analysis of the second biological signal or feature thereof based on detecting the end of the seizure.", "In some embodiments, the present disclosure relates to a method, comprising: sensing a first biological signal or feature thereof with a first sensor; analyzing the first biological signal or feature thereof to determine at least one change in said signal or feature thereof; detecting a possible brain state change based on the at least one change of the first biological signal or feature thereof, wherein the detecting comprises comparing the signal or feature thereof to a reference value; initiating at least one responsive action comprising analyzing a second biological signal or feature thereof in response to the detecting; and confirming or not confirming the possible brain state change based on the analyzing the second biological signal or feature thereof.", "In some embodiments, the present disclosure relates to a method, comprising: gathering a first biological signal or feature thereof from a patient; receiving an indication to gather a second biological signal or feature thereof from the patient; gathering the second biological signal or feature thereof; determining at least one of a sensitivity, a specificity, or a speed of detection of a pathological state in the patient from both the first biological signal or feature thereof and the second biological signal or feature thereof; continuing gathering of the biological signal or feature thereof having a better sensitivity of detection, a better specificity of detection, or a better speed of detection; and stopping gathering of the biological signal or feature thereof having a poorer sensitivity of detection, a poorer specificity of detection, or a poorer speed of detection.", "In other embodiments, the present disclosure relates to a medical device system, comprising a first sensor configured to sense a first biological signal or feature thereof from a patient; a first signal or feature thereof recorder module configured to record the first biological signal or feature thereof; a first signal or feature thereof analysis module configured to analyze the first biological signal or feature thereof; a controller configured to generate a first indication based on biological signal or feature thereof to activate at least one of a second sensor, the second signal or feature thereof recorder module, or the second signal or feature thereof analysis module, such that all of the second sensor, the second signal or feature thereof recorder module, and the second signal or feature thereof analysis module are activated and to generate a second indication based on the second biological signal or feature thereof to deactivate at least one of the first sensor, the first signal or feature thereof recorder module, or the second signal or feature thereof analysis module; and a memory configured to store at least the first analyzed biological signal or feature thereof.", "In some embodiments, the present disclosure relates to a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform a method as described above." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to and is a divisional application of U.S. patent application Ser.", "No.", "14/205,164, entitled “Contingent Acquisition and Analysis of Biological Signal or Feature Thereof for Epileptic Event Detection”, filed on Mar.", "11, 2014, U.S. patent application Ser.", "No.", "14/205,164 claims priority to U.S.", "Provisional Application Ser.", "No.", "61/799,953, filed Mar.", "15, 2013.U.S.", "patent application Ser.", "No.", "14/205,164 and U.S.", "Provisional Application Ser.", "No.", "61/799,953 are hereby incorporated in their entireties herein by reference.", "FIELD OF THE INVENTION This disclosure relates to medical device systems and methods capable of detecting epileptic seizures.", "SUMMARY OF THE INVENTION In some embodiments, the present disclosure relates to a method, comprising: receiving a first indication to gather a first biological signal or feature thereof from a patient; gathering the first biological signal or feature thereof; receiving a second indication to stop gathering the first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping gathering the first biological signal or feature thereof.", "In some embodiments, the present disclosure relates to a method, comprising: sensing a first biological signal or feature thereof with a first sensor; recording the first biological signal or feature thereof; sensing a second biological signal or feature thereof with a second sensor; recording the second biological signal or feature thereof; buffering the second biological signal or feature thereof to a memory buffer; analyzing the first biological signal or feature thereof to determine at least one feature; detecting a brain state change based on the at least one feature of the first biological signal or feature thereof; initiating analysis of the second biological signal or feature thereof in response to detecting the brain state change; confirming or not confirming the brain state change based on the analysis of the second biological signal or feature thereof; detecting an end of the brain state change based on at least one of the first biological signal or feature thereof or the second biological signal or feature thereof; and stopping analysis of the second biological signal or feature thereof based on detecting the end of the seizure.", "In some embodiments, the present disclosure relates to a method, comprising: sensing a first biological signal or feature thereof with a first sensor; analyzing the first biological signal or feature thereof to determine at least one change in said signal or feature thereof; detecting a possible brain state change based on the at least one change of the first biological signal or feature thereof, wherein the detecting comprises comparing the signal or feature thereof to a reference value; initiating at least one responsive action comprising analyzing a second biological signal or feature thereof in response to the detecting; and confirming or not confirming the possible brain state change based on the analyzing the second biological signal or feature thereof.", "In some embodiments, the present disclosure relates to a method, comprising: gathering a first biological signal or feature thereof from a patient; receiving an indication to gather a second biological signal or feature thereof from the patient; gathering the second biological signal or feature thereof; determining at least one of a sensitivity, a specificity, or a speed of detection of a pathological state in the patient from both the first biological signal or feature thereof and the second biological signal or feature thereof; continuing gathering of the biological signal or feature thereof having a better sensitivity of detection, a better specificity of detection, or a better speed of detection; and stopping gathering of the biological signal or feature thereof having a poorer sensitivity of detection, a poorer specificity of detection, or a poorer speed of detection.", "In other embodiments, the present disclosure relates to a medical device system, comprising a first sensor configured to sense a first biological signal or feature thereof from a patient; a first signal or feature thereof recorder module configured to record the first biological signal or feature thereof; a first signal or feature thereof analysis module configured to analyze the first biological signal or feature thereof; a controller configured to generate a first indication based on biological signal or feature thereof to activate at least one of a second sensor, the second signal or feature thereof recorder module, or the second signal or feature thereof analysis module, such that all of the second sensor, the second signal or feature thereof recorder module, and the second signal or feature thereof analysis module are activated and to generate a second indication based on the second biological signal or feature thereof to deactivate at least one of the first sensor, the first signal or feature thereof recorder module, or the second signal or feature thereof analysis module; and a memory configured to store at least the first analyzed biological signal or feature thereof.", "In some embodiments, the present disclosure relates to a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform a method as described above.", "BRIEF DESCRIPTION OF THE DRAWINGS The disclosure may be understood by reference to the following description taken in conjunction with the accompanying drawings, in which like reference numerals identify like elements, and in which: FIG.", "1 shows a schematic diagram of a medical device system, in accordance with some embodiments of the present disclosure; FIG.", "2 shows a schematic diagram of data acquisition components of a medical device system, in accordance with some embodiments of the present disclosure; FIG.", "3 shows a schematic diagram of a second biological signal or feature thereof module, according to some embodiments of the present disclosure; FIG.", "4 shows a flowchart depiction of a method, according to some embodiments of the present disclosure; FIG.", "5 shows a flowchart depiction of a method, according to some embodiments of the present disclosure; FIG.", "6 shows a flowchart depiction of a method, according to some embodiments of the present disclosure; FIG.", "7 shows a flowchart depiction of a method, according to some embodiments of the present disclosure; FIG.", "8 shows a flowchart depiction of a method, according to some embodiments of the present disclosure; and FIG.", "9 shows a flowchart depiction of a method, according to some embodiments of the present disclosure.", "While the disclosure is susceptible to various modifications and alternative forms, specific embodiments thereof have been shown by way of example in the drawings and are herein described in detail.", "It should be understood, however, that the description herein of specific embodiments is not intended to limit the disclosure to the particular forms disclosed, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the disclosure as defined by the appended claims.", "DETAILED DESCRIPTION OF SPECIFIC EMBODIMENTS Illustrative embodiments of the disclosure are described herein.", "For clarity, not all features of an actual implementation are described.", "In the development of any actual embodiment, numerous implementation-specific decisions must be made to achieve design-specific goals, which will vary from one implementation to another.", "Such a development effort, while possibly complex and time-consuming, would nevertheless be a routine undertaking for persons of ordinary skill in the art having the benefit of this disclosure.", "More information regarding testing of a patient's responsiveness and/or awareness may be found in other patent applications assigned to Flint Hills Scientific, L.L.C.", "or Cyberonics, Inc., such as, U.S. Ser.", "No.", "12/756,065, filed Mar.", "7, 2010.Any patent application identified in this paragraph is hereby incorporated herein by reference.", "More information regarding detecting an epileptic event from cardiac data, as well as information regarding measures of central tendency that can be determined from time series of body data, may be found in other patent applications assigned to Flint Hills Scientific, L.L.C.", "or Cyberonics, Inc., such as, U.S. Ser.", "No.", "12/770,562, filed Apr.", "29, 2010; U.S. Ser.", "No.", "12/771,727, filed Apr.", "30, 2010; U.S. Ser.", "No.", "12/771,783, filed Apr.", "300, 2010; U.S. Ser.", "No.", "12/884,051, filed Sep. 16, 2010; U.S. Ser.", "No.", "13/554,367, filed Jul.", "20, 2012; U.S. Ser.", "No.", "13/554,694, filed Jul.", "20, 2012; U.S. Ser.", "No.", "13/559,116, filed Jul.", "26, 2012; and U.S. Ser.", "No.", "13/598,339, filed Aug. 29, 2012.Each of the patent applications identified in this paragraph is hereby incorporated herein by reference.", "More information regarding detecting an epileptic event from multiple body data types, and examples of such body data types, may be found in other patent applications assigned to Flint Hills Scientific, L.L.C.", "or Cyberonics, Inc., such as, U.S. Ser.", "No.", "12/896,525, filed Oct. 1, 2010, now U.S. Pat.", "No.", "8,337,404, issued Dec. 25, 2012; U.S. Ser.", "No.", "13/098,262, filed Apr.", "29, 2011; U.S. Ser.", "No.", "13/288,886, filed Nov. 3, 2011; U.S. Ser.", "No.", "13/554,367, filed Jul.", "20, 2012; U.S. Ser.", "No.", "13/554,694, filed Jul.", "20, 2012; U.S. Ser.", "No.", "13/559,116, filed Jul.", "26, 2012; and U.S. Ser.", "No.", "13/598,339, filed Aug. 29, 2012.Each of the patent applications identified in this paragraph is hereby incorporated herein by reference.", "More information regarding automated assessments of disease states, comorbidities, and the like may be found in other patent applications assigned to Flint Hills Scientific, L.L.C.", "or Cyberonics, Inc., such as, U.S. Ser.", "No.", "12/816,348, filed Jun.", "15, 2010; and U.S. Ser.", "No.", "12/816,357, filed Jun.", "15, 2010.Each of the patent applications identified in this paragraph is hereby incorporated herein by reference.", "More information regarding detection, assessment, and management of extreme disease states, such as extreme epileptic events, may be found in other patent applications assigned to Flint Hills Scientific, L.L.C.", "or Cyberonics, Inc., such as, U.S. Ser.", "No.", "13/040,996, filed Mar.", "4, 2011; U.S. Ser.", "No.", "13/091,033, filed Apr.", "20, 2011; U.S. Ser.", "No.", "13/472,365, filed May 15, 2012; and U.S. Ser.", "No.", "13/333,235, filed Dec. 21, 2011.Each of the patent applications identified in this paragraph is hereby incorporated herein by reference.", "More information regarding the detection of brain or body activity using sensors implanted in proximity to the base of the skull may be found in other patent applications assigned to Flint Hills Scientific, L.L.C.", "or Cyberonics, Inc., such as, U.S. Ser.", "No.", "13/678,339, filed Nov. 15, 2012.Any patent application identified in this paragraph is hereby incorporated herein by reference.", "Biological signals generated by organs other than the brain (referred to hereinafter as extracerebral signals) are less specific and less sensitive for the detection of epileptic seizures than those originating from the cerebral cortex.", "To address this limitation, and to make extracerebral detection comparable in clinical utility to cortical signals, acquisition, processing and analysis of more than one extracerebral signal may be required.", "Since this strategy may negate (at least in part) the computational cost saving inherent in extracerebral signals, the present disclosure provides an approach whereby a second signal is acquired, processed, or analyzed in response to certain cues such as a detection of a pathological state (e.g., a seizure).", "The present approach may this be considered as a contingent approach to processing some signals.", "Some embodiments herein provide for performing an acquisition and/or analysis of a biological signal of a patient in response to a detected event.", "In one embodiment, the detected event may be a detection of a brain state change (e.g., an epileptic seizure).", "The detection of the brain state change may be performed by acquiring and analyzing a different biological signal of the patient from that on which the detection was based.", "For example, a detection of a brain state change may be performed by acquiring and analyzing a respiratory signal of a patient.", "Upon detection of the brain state change, another biological signal, e.g., a cardiac signal, may be acquired.", "Further analysis of the brain state change may then be performed.", "More specifically, in some embodiments, acquisition of at least a second biological signal, which may be triggered by the detection of a brain state change based upon a first biological signal, may be used to perform a confirmation process.", "The second biological signal may be analyzed to determine whether to confirm or deny the detection of the brain state change, or to assess therapeutic efficacy.", "In other embodiments, in addition to the confirmation process, the second biological signal may be analyzed to determine the type and severity of the brain state change.", "Still further, in other embodiments, the second biological signal may be analyzed to determine the type of responsive action to be taken, e.g., type of notification and/or treatment.", "Embodiments herein provide for increasing the efficiency of signal processing and analysis, improving the detection of state changes, and decreasing the processor burden of a medical device for predicting, detecting and/or treating an epileptic event.", "For example, the first biological signal may be a signal that is relatively easy to acquire and analyze.", "For example, a heart rate detector may be used to acquire the heart rate of the patient.", "The heart rate may then be compared to a threshold heart rate.", "If the detected heart rate crosses the threshold, a second biological signal, such as respiratory signal or a more complex cardiac signal, such as the heart rate variability (HRV) or EKG morphology, may be acquired and analyzed.", "The second biological signal may then be used to predict, detect, quantify or treat an epileptic event, or assess the efficacy or adverse effects of a therapy.", "In some examples, acquiring the second biological signal may be more computationally costly.", "Accordingly, acquisition and analysis of the second biological signal may be performed only when triggered by the first biological signal, which reduces the processor and/or computational burden on the medical device.", "In some embodiments, low complexity/computationally inexpensive signals may be used as “sentinel” signals that are used to trigger or “summon” other signals when needed.", "This may provide for smaller devices, smaller batteries, and/or longer life—which may be significant factors in determining whether an implantable medical device may be commercially viable.", "In this manner, more efficient and cost-effective prediction, detection, and/or treatment of pathological events (e.g., an epileptic seizure) may be provided.", "FIG.", "1 shows a schematic representation of a medical device system, according to some embodiments of the present disclosure.", "The medical device system 100 may comprise a medical device 200, first sensor(s) 212, lead(s) 211 coupling the first sensor(s) 212 to the medical device 200, second sensor(s) 214, and lead(s) 213 coupling the second sensor(s) 214 to the medical device 200.The sensors 212 are capable of detecting a variety of biological signals of the patient, such as autonomic signals, neurological signals, endocrine signals, metabolic signals, tissue stress signals, etc.", "Further, the medical system 100 may also comprise one or more electrodes 206 for delivering electrical signal therapy to a portion of the patient's body, e.g., the vagus nerve.", "Therapeutic electrical signals may be sent from the medical device 200 to the electrodes 206 via lead(s) 205.Various components of the medical device 200, such as controller 210, processor 215, memory 217, power supply 230, communication unit 240, warning unit 192, therapy unit 194, logging unit 196, and severity unit 198 have been described in other patent applications assigned to Flint Hills Scientific, LLC or Cyberonics, Inc., such as those incorporated by reference, supra.", "The medical device 200 may comprise a signal recorder module 150 configured to record a first biological signal or a feature of the first biological signal, e.g., a signal or feature thereof collected from sensor(s) 212 or 214.The signal recorder module 150 may receive directly from the sensors 212, 214, or alternatively, from a body data module 175, which is capable of receiving and processing a plurality of biological signals.", "The body data module 175 is described in further details below.", "The signal recorder module 150 is capable of storing analog and/or digital body signals.", "In some embodiments, the signal recorder module 150 is capable of correlating, stacking, and organizing data for orderly recovery and statistical analysis.", "In one embodiment multiple signal recording modules may be utilized, while in other embodiments a single signal recorder is endowed with multiplexing capacity.", "In one embodiment, multiple signals may be contingently multiplexed through one module.", "In another embodiment, signals may be prioritized for multiplexing based on certain metrics (e.g., sensitivity, specificity, and/or speed of detection).", "As part of contingent multiplexing or prioritizing multiplexing, signals may be added or removed from a filter bank.", "The medical device 200 may comprise a signal analysis module 160 configured to analyze biological signals or features thereof.", "“Analyze” here may include processing of raw recorded signals or features thereof (e.g., filtering, amplifying, etc.)", "to yield processed signals or features thereof, and/or the performance of one or more calculations on the processed signals or features thereof to yield informative data.", "For example, if the first biological signal or feature thereof is an electrocardiography (EKG) signal or feature thereof, the signal or feature thereof may be processed, then calculations may be performed to determine the patient's heart rate e.g., R-R intervals from the EKG signal or feature thereof.", "In some embodiments, the signal analysis module 160 may be configured to determine a first feature of the first biological signal or feature thereof, wherein the first feature is one of power in certain frequency band, a rhythmicity index, a waveform morphology, a synchronization level, a direction of a movement, an amplitude of a movement or an acceleration of a movement.", "Recording, processing, and performing calculations on a signal or feature thereof may together be referred to as “gathering” a signal or feature thereof.", "As should be apparent, all of the first sensor, the signal or feature thereof recorder module, and the signal or feature thereof analysis module should be activated if it is desired to gather a signal or feature thereof collectable by the first sensor.", "In some embodiments, the first biological signal or feature thereof is an electroencephalography (EEG) signal or feature thereof, an electrocorticography (ECoG) signal or feature thereof, an EKG signal or feature thereof, a kinetic signal or feature thereof, a reaction time signal or feature thereof, an awareness signal or feature thereof, or a responsiveness signal or feature thereof.", "In some embodiments, the first biological signal or feature thereof is an electrocardiography (EKG) signal or feature thereof and the signal or feature thereof analysis module is configured to determine a first feature of the first biological signal or feature thereof, wherein the first feature is one of heart rate, heart rate variability, EKG morphology, heart rhythm, or Q-T interval.", "The controller 210 may be configured to generate a first indication based at least in part on a second biological signal or feature thereof (such as may be provided by second body data module 180, described below) to activate at least one of the first sensor, the signal or feature thereof recorder module, or the signal or feature thereof analysis module, such that all of the first sensor, the signal or feature thereof recorder module, and the signal or feature thereof analysis module are activated.", "In some embodiments, the second biological signal or feature thereof may be an electrocardiography (EKG) signal or feature thereof.", "In one embodiment, the first biological signal may be a cardiac signal (EKG) and the second signal may be a cortical signal (ECoG).", "As used herein, the first biological signal generally refers to a signal which is most being used as the sentinel signal to trigger the recording of the second signal, while the second biological signal refers to a signal which is contingently acquired based on the first signal.", "Alternatively or in addition, the controller 210 may be configured to generate at least one of the first indication or the second indication, based at least in part on at least one exosomatic signal or feature thereof.", "In some embodiments, the at least one exosomatic signal or feature thereof may be a time of day signal or feature thereof, a time of month signal or feature thereof, a luminance level signal or feature thereof, an acoustic noise level signal or feature thereof, a temperature signal or feature thereof, a barometric pressure signal or feature thereof, a signal or feature thereof indicative of a physical activity of the patient and when it was performed by the patient, a signal or feature thereof indicative of an attention level of the patient and when the patient was attentive, a signal or feature thereof indicative of a cognitive activity of the patient, the type of cognitive activity and when it was performed by the patient, a signal or feature thereof indicative of a time elapsed since the last seizure of the patient, the last seizure type or class, the last seizure severity of the patient, a signal or feature thereof indicative of a time elapsed since the delivery of a therapy to the patient, the type of therapy and its dose or parameters, the efficacy of the therapy, delivered to the patient, the adverse effects of the therapy and their type and severity, or a signal or feature thereof indicative of a time elapsed since the last caloric intake and its amount, a signal or feature thereof indicative of stress level and when it changes of the patient.", "The controller 210 may also be configured to generate a second indication based on the second biological signal or feature thereof to deactivate at least one of the first sensor, the signal or feature thereof recorder module, or the signal or feature thereof analysis module.", "By doing so, the first biological signal or feature thereof would not be gathered/acquired.", "In some embodiments, the first indication is based on a seizure event onset determined from the second biological signal or feature thereof, and the second indication is based on a seizure event end determined from the second biological signal or feature thereof.", "(“End” here refers to the return of a body data series indicative of the seizure returning to baseline, either spontaneously or in response to applied therapy.", "A seizure end in response to applied therapy may be termed a “termination”).", "The seizure event onset and seizure event end may be determined by a brain state change detection module 170.The brain state change detection module 170 may be configured to detect a brain state change, based at least in part on a biological signal or feature thereof, such as the first biological signal, or feature thereof, the second biological signal or feature thereof, or both.", "In some embodiments, the brain state change is an epileptic event, such as a seizure.", "The brain state change detection module 170 is capable of detecting electrical, and/or chemical changes relating to a portion of a patient's brain by analyzing body data indicative of the state of the patient's brain.", "In one embodiment, the brain state change detection module 170 may be configured to detect a brain state change based on the first biological signal or feature thereof, and may be configured to detect the end of the brain state change based on the second biological signal or feature thereof.", "Alternatively or in addition, the brain state change detection module 170 may be configured to use the second biological signal or feature thereof to provide a secondary analysis regarding brain state changes, e.g., to determine if false positive/false negative performance of brain state change detections made by the brain state change detection module 170 based on the first biological signal or feature thereof is satisfactory, by using the second biological signal or feature thereof.", "Alternatively or in addition, the brain state change detection module 170 may be configured to provide a first indication usable by one or more of the units 192-198 to warn, deliver a therapy, determine a severity, and/or log the occurrence of a brain state change, based on the first biological signal or feature thereof, and to provide a second indication usable by one or more of the units 192-198 to terminate or rescind a warning, terminate or rescind delivery of a therapy, terminate determining a severity, and/or terminate or rescind logging the occurrence of a brain state change, based on the second biological signal or feature thereof.", "The memory 217 may be configured to store at least the first and/or the second analyzed biological signals or features thereof.", "The medical device 200 may further comprise a body data module 175, configured to gather a plurality of biological signals or features thereof and provide it or data based on it to other elements, e.g., brain state change detection module 170.FIG.", "2 shows data acquisition elements of the medical device system 100 in more detail.", "FIG.", "2 depicts an exemplary implementation of the body data module 175 described above with respect to FIG.", "1.The body data module 175 may include a body data memory 250 for storing and/or buffering data in the body data collection module 175.The body data memory 250 may, in some embodiments, be adapted to store body data for logging or reporting purposes and/or for future body data processing.", "The body data collection module 175 may also include one or more body data interfaces 255.The body data interface 255 may provide an interface for input/output (I/O) communications between the body data module 175 and body data acquisition units/modules (e.g., [260-270], [273-276]) via connection 280.Connection 280 may a wired or wireless connection, or a combination of the two.", "The connection 280 may be a bus-like implementation or may include an individual connection (not shown) for each, or some number, of the body data acquisition units (e.g., [260-270], [273-276]).", "The connection 280 may also include connection elements as would be known to one of skill in the art having the benefit of this disclosure.", "The specific implementation of the connection 280 does not serve to limit other aspects of various embodiments described herein unless specifically described.", "In various embodiments, the body data acquisition units may include, but are not limited to, an autonomic data acquisition unit 260, a neurologic data acquisition unit 270, and endocrine data acquisition unit 273, a metabolic data acquisition unit 274 and/or a tissue stress marker data acquisition unit 275.In one embodiment, the body data units may include a physical fitness determination unit 276.In one embodiment, the autonomic data acquisition unit 260 may include a heart beat data acquisition unit 261 adapted to acquire heart sounds, EKG data, PKG data, heart echo, apexcardiography and/or the like, a blood pressure acquisition unit 263, a respiration acquisition unit 264, a blood gases acquisition unit 265, and/or the like.", "In one embodiment, the neurologic data acquisition unit 270 may contain a kinetic unit 266 that may comprise an accelerometer unit 267, an inclinometer unit 268, and/or the like; the neurologic data acquisition unit 270 may also contain a responsiveness/awareness unit 269 that may be used to determine a patient's responsiveness to testing/stimuli and/or a patient's awareness of their surroundings.", "These lists are not inclusive, and the body data module 175 may collect additional data not listed herein, that would become apparent to one of skill in the art having the benefit of this disclosure.", "The body data acquisition units ([260-270], [273-276]) may be adapted to collect, acquire, receive and/or transmit heart beat data, EKG data, PKG data, heart echo, apexcardiography, heart sound data, blood pressure data, respiration data, blood gases data, body acceleration data, body incline data and/or the like.", "The body data interface(s) 255 may include various amplifier(s) 256, one or more A/D converters 257 and/or one or more buffers 258 or other memory (not shown).", "In one embodiment, the amplifier(s) 256 may be adapted to boost incoming and/or outgoing signal strengths for signals such as those to/from any body data acquisition units/modules (e.g., ([260-270], [273-276]) or signals to/from other units/modules of the medical device 200.The A/D converter(s) 257 may be adapted to convert analog input signals from body data acquisition unit(s)/module(s) (e.g., ([260-270], [273-276]) into a digital signal or feature thereof format for processing by controller 210 (and/or processor 215).", "Such analog signals may include, but are not limited to, heart beat data, EKG data, PKG data, heart echo, apexcardiography, heart sound data, blood pressure data, respiration data, blood gases data, body acceleration data, body incline data, and/or the like.", "A converted signal or feature thereof may also be stored in a buffer(s) 258, a body data memory 250, or some other memory internal to the medical device 200 (e.g., memory 217) or external to the medical device 200 (e.g., one or more of a monitoring unit, a local database unit, a remote database unit, or a remote device, among others (not shown)).", "The buffer(s) 240 may be adapted to buffer and/or store signals received by the body data module 175 as well as signals to be transmitted by the body data module 175.In various embodiments, the buffer(s) 258 may also be adapted to buffer and/or store signals in the body data—module 175 as these signals are transmitted between components of the body data—module 175.FIG.", "3 shows a schematic representation of the second body data module 180 according to some embodiments of the present disclosure.", "The second body data module 180 may comprise a second signal or feature thereof recorder module 310 and a second signal or feature thereof analysis module 320 to perform various signal or feature thereof gathering tasks, analogously to the signal or feature thereof recorder module 150 and the signal analysis module 160 described above.", "The second body data module 180 may comprise a first indication module 330 configured to make use of data provided by the signal or feature thereof gathering elements 310-320 to provide an indication to gather the first signal or feature thereof.", "Similarly, the second body data module 180 may comprise a second indication module 340 to provide an indication to stop gathering the first signal or feature thereof.", "The second body data module 180 may comprise a seizure event onset module 350 configured to make use of data provided by the signal or feature thereof gathering elements 310-320 to detect a seizure onset.", "The detected seizure onset may be used by the first indication module 330 in determining whether to provide the first indication to gather the first signal or feature thereof.", "Similarly, the second body data module 180 may comprise a seizure event end module 360 configured to detect a seizure end.", "The detected seizure end may be used by the second indication module 340 in determining whether to provide the second indication to stop gathering the first signal or feature thereof.", "In some embodiments, the medical device system may comprise a first sensor configured to sense a first biological signal or feature thereof from a patient; a signal or feature thereof recorder module configured to record the first biological signal or feature thereof; a signal or feature thereof analysis module configured to analyze the first biological signal or feature thereof; a detection module configured to generate a first indication of a brain state change based on said first biological signal or feature thereof; a controller module configured to activate at least one of a second sensor configured to sense a second biological signal or feature thereof recorder module in response to a change in the first signal or feature thereof, a second signal or feature thereof analysis module, a second indication of a brain state change based on a change in the second biological signal or feature thereof; and a responsive action based on the concordance or discordance of said first and second signal or their features thereof, said action consisting of deactivation of at least one of the first sensor, the signal or feature thereof recorder module, or the signal or feature thereof analysis module; and a memory configured to store at least the first analyzed biological signal or feature thereof.", "In some embodiments, the present disclosure relates to a method, comprising: sensing a first biological signal or feature thereof with a first sensor; recording the first biological signal or feature thereof; analyzing the first biological signal or feature thereof to determine at least one feature; detecting a brain state change based on the at least one feature of the first biological signal or feature thereof; sensing a second biological signal or feature thereof with a second sensor in response to said detection of a brain state change; recording the second biological signal or feature thereof in response to said detection of a brain state change; initiating analysis of the second biological signal or feature thereof in response to detecting the brain state change; confirming or not confirming the brain state change based on the analysis of the second biological signal or feature thereof; detecting an end of the brain state change based on at least one of the first biological signal or feature thereof or the second biological signal or feature thereof; and stopping analysis of the second biological signal or feature thereof based on detecting the end of the seizure.", "Turning now to FIG.", "4, a flowchart depiction of a method 400 of performing a contingent acquisition of biological signal(s), in accordance with one embodiment, is illustrated.", "The medical device 200 may receive an indication to acquire or receive a first biological signal (block 410).", "The indication to acquire a biological signal may be one of many types of prompts that may initiate acquisition of biological signals.", "For example, the indication may be an input from an external entity to start acquiring biological data (block 412).", "In some instances, the patient may feel a change in his or her body, wherein the change may be indicative of an occurrence of an epileptic event.", "As a result, the patient may provide an input to the medical device 200 indicating the change.", "The input may be a magnet swipe input, a tap sensor input, or an electronic input, wherein the input may initiate the acquisition of biological data.", "In other embodiments, the indication to acquire biological data may be initiated by the detection of a brain state change (block 414).", "For example, the medical device 200 may detect an epileptic event based upon one or more detection methods, such detection based upon monitoring and analyzing one or more body data signals.", "For example, the heart rate may be monitored and analyzed to detect a possible a brain state change, which may trigger the acquisition of one or more additional biological signals.", "In this manner, a signal (e.g., heart rate) that is easy to acquire, has a high S/N or is computationally inexpensive to process, may be constantly monitored (“Sentinel” signal).", "Upon detecting a potential brain state change based upon a sudden change in the heart rate, further acquisition and analysis of another biological signal may be performed.", "Thereby, acquisition, processing and analysis of a biological signal that may have high complexity, low S/N or may be computationally expensive to process and analyze by the medical device 200 may only be contingently utilized in response to a certain cue (e.g., the onset of an epileptic event.)", "In this manner, more efficient use of the medical device 200, the battery, the processor, etc., of the medical device 200, may be realized while still performing efficient and cost-effective detection of one or more diseases in the patient's body.", "Further, another example of communication that initiates the acquisition of a first biological data may be the detection of a sudden change in the patient's body (block 416).", "One of a number of sudden changes in the patient's body may be detected by the medical device 200.One example of a sudden change may be a sudden change in breathing, a detection by an accelerometer of a certain change in movement in the patient's body, a sudden change in an inclinometer output indicating a sudden shift in the position of the patient's body, etc.", "Based on the sudden change in the patient's body, the acquisition of more complex or more taxing acquisition of another biological signal may be performed.", "Another example of an indication to acquire or receive the first biological signal may be a predetermined time period for acquiring body data (block 418).", "For example, a patient's history may indicate that certain epileptic events may occur at particular times for a patient; therefore, a pre-determined time may be determined by the medical device 200 to provide an automated indication to initiate acquisition and analysis of a biological signal.", "Those skilled in the art having benefit of the present disclosure, will appreciate that other types of indications may be provided to the medical device 200 for initiating the acquisition and/or analysis of biological signal, and still remain within the scope and spirit of the present embodiments.", "Upon receiving indication to acquire or receive a first biological signal, the medical device 200 may begin acquisition and/or receiving of the first biological signal (block 420).", "In some examples sensors operatively coupled to the medical device 200 may be utilized to acquire the biological signals.", "In other embodiments, external devices may acquire and provide the biological signals to the medical device 200.In some embodiments, the biological signals may be processed and analyzed by the medical device 200 for performing proper detection, predictions, or other analysis.", "In other embodiments, the acquired or received biological signals may be stored and/or transmitted to an external entity for further analysis.", "In some cases, the acquisition and receiving of the first biological signal may be relatively taxing on the resources of the medical device system 100.Therefore, efficient timing and limitation of the acquisition process may be desirable.", "As such, upon acquiring and receiving the first body signal, the medical device system 100 may monitor for an indication to stop the acquisition and/or receiving of the first biological signal (block 430).", "The medical device 200 may determine whether it has received an indication to stop the acquisition of the first biological signal (block 440).", "Upon a determination that no such indication has been received, the medical device system 200 may continue acquiring the first biological signal (block 450).", "Upon continuing the acquisition of the biological signal, the medical device 200 may continue to monitor for an indication to stop the acquisition, as indicated by the flow from block 440, to block 450, to block 430 and back to block 440.In some embodiments, the signal to stop or terminate receiving the first biological signal may occur in response to a determination to switch to a different first body signal for use as a fiducial in monitoring the patient's condition.", "The indication to stop acquiring or receiving biological signal may be in one of several forms, as exemplified in FIG.", "4 (blocks 442, 444, 446, and 448).", "In some embodiments, the indication to stop acquiring may take on the form of a termination of indication to acquire biological signals (block 442).", "For example, after the acquisition of the second signal is initiated, subsequent data may indicate that the acquisition of the signal is unnecessary, in which case the acquisition of the second signal may be terminated or stopped.", "For example, data (e.g., exosomatic data) may indicate that the probability of an epileptic brain state has become sufficiently low to merit termination of acquisition of the second signal.", "In other examples, a constant polling of a signal may be made to determine whether the indication to acquire data is still active.", "In other embodiments, a periodic signal may be sent to the medical device 200 indicating to continue acquisition of the biological data, and upon a missed periodic signal, an interpretation may be made that it was a termination of an indication to acquire biological signal.", "Another example of an indication to stop acquisition may be an input from an external entity stop acquiring data (block 444).", "In some examples, the patient may provide an input to stop the acquisition upon feeling that the patient's body is functioning properly.", "Other external indications may be provided by from an external device, or manually from a medical professional.", "Another example of an indication to stop acquisition may be a check to determine if there is an end to the brain state change that initially had triggered the acquisition (block 446).", "Therefore, the detection and analysis of a brain state change may lead to determination of the indication to acquire biological signal.", "Further, upon a detection of a change or a return to a previous baseline state in the patient's body, an indication may be interpreted to have been received to stop acquisition (block 448).", "For example, if an inclinometer indicates that the patient is in a proper upright position for a predetermined period of time, an indication will be provided to stop the acquisition of biological signal.", "Other indications may include an accelerometer-reading indicating normal patient movement, which may trigger the termination of the acquisition of biological signal.", "Upon determining that an indication to stop acquiring or receiving biological signal has been received (block 440), the medical device 200 may stop the acquisition and reception of the biological signal (block 460).", "In this manner, biological signal acquisition is contingent upon cues and occurs only when needed, and the acquisition may be terminated when the need is satisfied.", "Therefore, a more efficient operation of acquisition, analysis and termination of acquisition of body signals is provided by embodiments herein.", "In one embodiment, signal acquisition or processing or analysis may be discontinued during periods or conditions/states associated with low probability of occurrence of pathological events (e.g., seizures).", "This may be implemented, for example, in monitoring patients with nocturnal frontal lobe epilepsy in whom the probability of having a seizure while awake is negligible.", "In another example at a different timescale, monitoring may occur only during the premenstrual period in women having catamenial epilepsy.", "In other patients, the monitoring may be discontinued when the patient is in a neuroprotected state, or when the safety or social risks to the patient associated with seizures are minimal.", "Turning now to FIG.", "5, a flowchart depiction of a method 500 for performing the contingent acquisition and/or recording of a body signal, in accordance with an alternative embodiment, is illustrated.", "The medical device 200 may acquire a first body signal (block 510).", "Upon acquisition of the first body signal, the medical device 200 may analyze the data relating to the first body signal (block 520).", "This analysis may comprise processing the first body signal, converting the first body signal into digital data, performing comparisons to reference or threshold values, and/or performing comparison to shapes of at least a portion of the body signal to reference shapes.", "Based upon analysis of the data relating to the first body signal, the medical device 200 may determine whether a possible brain state change exists (block 530).", "Possible brain state change may relate to one or more indications that a change in the patient's body has been detected and an impending epileptic event may be possible.", "Upon a determination that a possible brain state change has not been detected, the medical device 200 may continue acquiring body data at predetermined time periods (block 540).", "Subsequently, this data may be analyzed and a determination may be made whether there exists a possible brain state change (see flow from block 530, to 540, to 520 and back to 530).", "In some embodiments the first body signal may be a signal that can be acquired with relative ease and use of minimal resources of the medical device system 100.Therefore, a minimal use of computing resources and power may be utilized while monitoring the first body signal and performing analysis to detect a possible brain state change.", "Upon a detection of a possible brain state change (block 530), acquisition or reception of a second body signal may be performed (block 550).", "In some embodiments the acquisition of the second body signal may involve acquiring more complex signals that may require greater in-depth analysis.", "Therefore, in some embodiments, this process may only be performed when triggered by the detection of a possible brain state change, thereby providing for efficient detection of an epileptic event.", "Upon acquisition of the second body signal (block 550), data representative of that signal may be analyzed (block 560).", "The analysis of the data relating to the second body signal may comprise processing the second body signal and performing analysis.", "The analysis may include performing comparisons of features of the signal, including amplitude, frequency, morphology, etc.", "The medical device 200 may then determine whether the brain state change is confirmed (block 570).", "That is, the analysis of the second body signal may be used to confirm the possible brain state change detected by the analysis of the first body signal.", "Therefore, the possible brain state change of block 530 may be confirmed as an actual brain state change, or may be denied (block 570).", "This determination may be based on the analysis performed on second body signal.", "Upon a determination that the brain state change has not been confirmed, the flow moves from block 570 to block 540, where the acquisition of body data may be continued at predetermined time periods.", "Upon a determination that the brain state change is confirmed, a responsive action may be performed by the medical device system 100 (block 580).", "The responsive action may comprise one or more of providing a therapy, logging one or more data sets relating to the acquisition of the first and/or second body signals, as well as data relating to the comparison and the results of such comparisons described above.", "Further, the responsive action may include notifying one or more entities regarding the brain state change confirmation.", "In some embodiments, when a brain state change has not been confirmed (block 570), the acquisition of body signals may be suspended for a predetermined time period.", "In this manner, resources of the medical device system 100 are conserved when brain state changes are not present.", "Turning now to FIG.", "6a flowchart representation of a method of performing a contingent acquisition, in accordance with another alternative embodiment, is illustrated.", "The method 600 may comprise receiving a first indication to gather a first biological signal or feature thereof from a patient (block 630).", "The first biological signal or feature thereof may be an autonomic signal or feature thereof, a neurologic signal or feature thereof, a metabolic signal or feature thereof, an endocrine signal or feature thereof, or a tissue stress marker signal or feature thereof.", "For example, the first biological signal or feature thereof may be an EKG signal or feature thereof, a kinetic signal or feature thereof, an electroencephalography (EEG) signal or feature thereof, an electrocorticography (ECoG) signal or feature thereof, a reaction time signal or feature thereof, an awareness signal or feature thereof, or a responsiveness signal or feature thereof.", "The first indication may be based at least in part on at least one second biological signal or feature thereof from the patient gathered (block 601).", "The second biological signal or feature thereof may be an electrocardiography (EKG) signal or feature thereof or a kinetic signal or feature thereof.", "Alternatively or in addition, the first indication may be based at least in part on a first feature of the first signal or feature thereof (e.g., a value of the raw or a processed signal or feature thereof may be such that further analysis is desirable).", "For example, the second feature may be an R wave shape of an EKG signal, and the first, contingently gathered feature may be one of a T wave shape or of a Q-T interval.", "The first biological signal or feature thereof may be gathered (block 610), by which is meant that first biological signal or feature thereof is collected (block 612) via a sensor, processed (block 614), and analyzed (block 616).", "The first indication may activate one or more of elements 612-616, such that all three of elements 612-616 are performed.", "The first indication may be based at least in part on a detection of a brain state change onset, e.g., seizure onset, or entry into a period of increased seizure likelihood.", "Thereafter, the method 600 may comprise receiving a second indication to stop gathering the first biological signal or feature thereof (block 640).", "The second indication may be based at least in part on at least one second biological signal or feature thereof gathered (block 601) from the patient.", "The second indication may relate to a detection of an end of a brain state change (block 650) or to the determination that the detection was false.", "This detection may be based on a second biological signal or feature thereof gathered (block 601).", "In response, the method 600 may comprise stopping gathering the first biological signal or feature thereof, which may be considered with reference to FIG.", "6 as interruption of the flow from 612 to 614, 614 to 616, and/or 616 to one or more of 622-626.The gathered first biological signal or feature thereof may be stored (block 622) to a memory (e.g., memory 217), used as at least a partial basis for a seizure detection (block 624), or used to confirm (block 626) a seizure detection based on other data, e.g., a continuously gathered second biological signal or feature thereof.", "In some embodiments, the second biological signal or feature thereof may be selected from at least one of a cardiac signal or feature thereof, a kinetic signal or feature thereof, or a respiratory signal or feature thereof; the first biological signal or feature thereof may be selected from at least one of the cardiac signal or feature thereof, the kinetic signal or feature thereof, and the respiratory signal or feature thereof, provided the first biological signal or feature thereof is different from the second biological signal or feature thereof; the first indication may be based at least in part on the second biological signal or feature thereof; and the first indication may be indicative of an epileptic event.", "The first indication may be based at least in part on an occurrence of a seizure based on an EKG signal or feature thereof, and the second indication may be based at least in part on an end of the seizure based on the EKG signal or feature thereof.", "Alternatively or in addition, at least one of the first indication or the second indication may be based at least in part on at least one exosomatic signal or feature thereof Examples of such exosomatic signal or feature thereof may include a time of day signal or feature thereof, a time of month signal or feature thereof, a luminance level signal or feature thereof, an acoustic noise level signal or feature thereof, a temperature signal or feature thereof, a barometric pressure signal or feature thereof, a signal or feature thereof indicative of a physical activity of the patient and when it was performed by the patient, a signal or feature thereof indicative of an attention level of the patient and when the patient was attentive, a signal or feature thereof indicative of a cognitive activity of the patient, the type of cognitive activity and when it was performed by the patient, a signal or feature thereof indicative of a time elapsed since the last seizure of the patient, the last seizure type or class, the last seizure severity of the patient, a signal or feature thereof indicative of a time elapsed since the delivery of a therapy to the patient, the type of therapy and its dose or parameters, the efficacy of the therapy, delivered to the patient, the adverse effects of the therapy and their type and severity, or a signal or feature thereof indicative of a time elapsed since the last caloric intake and its amount, a signal or feature thereof indicative of stress level and when it changes of the patient.", "In some embodiments, the first and second biological signals or features thereof may be the same type of signal and/or same feature of a single signal collected at two different timescales, e.g., micro-, meso-, or macroscopic time scales.", "In some embodiments, the second biological signal or feature thereof may be gathered continuously, and at some time, an event is detected based on changes of the signal or feature thereof; the detection triggers the gathering of the first biological signal or feature thereof; once the detected event terminates, gathering the second signal or feature thereof may be stopped, simultaneously with the detection or sometime later.", "For example, in the case of tonic-clonic seizures, accelerometer data may be continuously gathered, and if a seizure is detected from this data, the first indication may be to gather EEG or responsiveness data.", "In some embodiments, the second biological signal or feature thereof is a cortical brain signal or feature thereof and the first biological signal or feature thereof is an electrocardiography (EKG) signal or feature thereof, a respiratory signal or feature thereof, a kinetic signal or feature thereof, a reaction time signal or feature thereof, an awareness signal or feature thereof, or a responsiveness signal or feature thereof.", "In some embodiments, the present disclosure relates to a method, comprising sensing a first (e.g., continuously-gathered) biological signal or feature thereof with a first sensor; recording the first biological signal or feature thereof; sensing a second (e.g., contingently-gathered) biological signal or feature thereof with a second sensor; recording the second biological signal or feature thereof; buffering the second biological signal or feature thereof to a memory buffer; analyzing the first biological signal or feature thereof to determine at least one feature; detecting a brain state change based on the at least one feature of the first biological signal or feature thereof; initiating analysis of the second biological signal or feature thereof in response to detecting the brain state change; confirming or not confirming the brain state change based on the analysis of the second biological signal or feature thereof; detecting an end of the brain state change based on at least one of the first biological signal or feature thereof feature or the second biological signal or feature thereof; and stopping analysis of the second biological signal or feature thereof based on detecting the end of the seizure.", "In some embodiments, the present disclosure relates to a method, comprising: sensing a first biological signal or feature thereof with a first sensor; analyzing the first biological signal or feature thereof to determine at least one feature; detecting a possible brain state change based on the at least one feature of the first biological signal or feature thereof, wherein the detecting comprises comparing the feature to a reference value; initiating at least one responsive action comprising analyzing a second biological signal or feature thereof in response to the detecting; and confirming or not confirming the possible brain state change based on the analyzing the second biological signal or feature thereof.", "In some embodiments, the first biological signal or feature thereof is selected from a heart rate signal or feature thereof, an accelerometer signal or feature thereof, or both; and the second biological signal or feature thereof is selected from a heart rate signal or feature thereof, an accelerometer signal or feature thereof, a respiratory rate signal or feature thereof, an oxygen saturation signal or feature thereof, or two or more thereof, provided the second biological signal or feature thereof is different from the first biological signal or feature thereof.", "To be clear, the first and second biological signals may be the same as sensed and processed by components of the device, but with different first and second features thereof determined by body data module 175 and/or second body data module 180 (FIG.", "1).", "In some embodiments, three signals or features thereof may be considered, with two continuously gathered (e.g., heart rate, accelerometer) and used to initiate gathering of e.g., a respiratory signal or feature thereof (e.g., respiratory rate, blood oxygen saturation, etc.).", "In some embodiments, when the patient is asleep, EKG only may be monitored, with a kinetic signal or feature thereof gathered contingently) in response to an increase in heart rate trigger analysis of buffered kinetic data, (e.g., the kinetic data is collected, processed, and stored in a short term buffer, but not analyzed, until an increase in heart rate occurs).", "Based on the analyzed kinetic data, a detection may be issued or not.", "The method of this embodiment may further comprise detecting an end of the brain state change based on at least one of the first biological signal or feature thereof or the second biological signal or feature thereof; and stopping analysis of the second biological signal or feature thereof based on the detecting the end of the brain state change.", "The responsive action referred to above may further comprise at least one of acquiring the second biological signal or feature thereof with a second sensor or buffering the second biological signal or feature thereof to a memory buffer.", "The first biological signal or feature thereof may be selected from an electrocardiography (EKG) signal or feature thereof, a respiratory signal or feature thereof, an electroencephalography (EEG) signal or feature thereof, an electrocorticography (ECoG) signal or feature thereof, or a kinetic signal or feature thereof and the second biological signal or feature thereof may be selected from a reaction time, an awareness signal or feature thereof, or a responsiveness signal or feature thereof.", "The first signal or feature thereof may be used to detect a seizure and the second signal or feature thereof may be used to classify the seizure.", "For example, the second signal or feature thereof may be used to classify the seizure as complex partial in response to the patient being unaware or unresponsive.", "Similar examples exist for other seizure types, e.g., tonic-clonic seizures, complex partial hypermotoric or hypomotoric seizures, etc.", "For example, complex partial hypermotoric seizures have loss of responsiveness and large spikes in accelerometer data.", "In some embodiments, threshold(s) and/or duration(s) of seizure detection algorithms, and/or issuing a warning regarding and/or logging the outputs of the seizure detection algorithms, may be based on results of contingent gathering, e.g., if heart rate-based seizure detection requires the heart rate to be above a seizure threshold for 5 sec, and accelerometer indication of a seizure is temporally correlated with a heart rate indication, then duration can be lowered.", "For example, the duration can be lowered to the time of accelerometer indication.", "FIG.", "7 presents a flowchart depiction of a method 700, according to some embodiments of the present disclosure.", "The method 700 may allow qualitative or quantitative ranking of the sensitivity, specificity, or both of one or more signals or features thereof.", "One or more banks of signals and/or features may be determined (at 710).", "The signals/features may be HR, HRV, EKG morphology, respiratory rate (RR), respiratory rate variability (RRV), EEG, EEG power variability at one or more frequency bands, etc.", "One or more of these signals/features may be processed (at 715) and analyzed (at 720).", "Whether or not a change in at least one signal/feature has occurred may be determined (at 730).", "If no change has occurred, it may be desirable to expand the bank(s) of features (at 735).", "On the other hand, if a change has occurred, it may be indicative of a pathological state in the patient.", "It may be desirable to confirm the occurrence of the pathological state, depending on the sensitivity and/or specificity of the signal/feature for indicating the occurrence of the pathological state.", "In the depicted embodiment, if a change occurred (as determined at 730), then it may be determined (at 740) if the signal/feature is highly sensitive to the pathological state of interest, e.g., that it has a sensitivity that places it in the top decile of signals/features.", "(By “change” is meant a significant deviation of a signal/feature value from a measure of central tendency thereof).", "If the signal/feature is determined to not be highly sensitive, then it may be determined (at 760) if the signal/feature is highly specific to the pathological state, e.g., that it has a specificity that places it in the top decile of signals/features.", "If the signal/feature is determined to be neither highly sensitive nor highly specific, then it may be considered as being an intermediate signal/feature.", "Signals/features may be also selected for speed of detection, that is, they are the first to change when a transition from a non-pathological to a pathological state occurs.", "Whether the signal/feature is highly sensitive, highly specific, or intermediate, upon a determination of its sensitivity/specificity (e.g., at 740 or 760), then whether a change in (an)other signal(s)/feature(s) occurred may be determined (e.g., at 742, 762, or for intermediate signals/features, 772).", "The other signal(s)/feature(s) may be selected such that a change in it/them may confirm or complement a change observed (at 730) in the main signal/feature of interest.", "For example, if the main signal/feature of interest is highly sensitive, then the other signal(s)/feature(s) considered (at 742) may be one(s) that are highly specific so as to decrease the probability of false positive detections.", "Similar considerations apply to the change determinations at 762 and 772.If a change in the other signal(s)/feature(s) is determined to have occurred (at 742, 762, or 772), then a responsive action may be performed (at 750).", "The responsive action may comprise (re)determining the main signal/feature's sensitivity or specificity, repeating the process (by returning to determining the signal/feature bank(s) at 710), or the like.", "Other responsive actions may include but are not limited to issuing a detection, a warning, logging data associated with the detection, or delivering a therapy.", "As should be apparent to the person of ordinary skill in the art, an explicit determination that the main signal/feature of interest is an intermediate signal/feature may be made, and/or 740, 760, and any explicit determination of an intermediate signal/feature may be made in any order.", "FIG.", "8 provides a flowchart depiction of a method 800 according to some embodiments of the present disclosure.", "Given a plurality of signals that may be gathered from body data of a patient, the most sensitive signal (i.e., the signal of the plurality which has the highest sensitivity for detecting a pathological state of interest) may be gathered (at 810) and processed (or analyzed) (at 820).", "Whether a change in the most sensitive signal has occurred may be determined (at 830).", "If the most sensitive signal has not changed, the method may return to gathering other sensitive signals (at 810).", "On the other hand, if the most sensitive signal has changed, then the most specific signal may be gathered (at 840) and processed (or analyzed) (at 850).", "Whether a change in the most specific signal has occurred may be determined (at 860).", "If a change in the most specific signal has occurred, then, in light of this change and the change in the most sensitive signal (previously determined at 830), i.e., that both signals agree that a pathological state occurred, then a responsive action may be taken (at 870).", "The responsive action may comprise one or more of issuing a detection of the pathological state, warning the patient or a caregiver of the detected pathological state, providing a therapy for the pathological state, logging an occurrence of the pathological state, processing or analyzing body data expected to be informative about the pathological state, or ceasing processing or analysis of body data not/no longer expected to be informative about the pathological state, among others.", "If no change occurred in the most specific signal, then the method may return to gathering the most sensitive signal (at 810), or it may optionally proceed to gather (at 880) and process or analyze (at 882) a third signal.", "Whether a change in the third signal has occurred may be determined (at 884).", "If a change in the third signal has occurred, then, in light of this change and the changes in the most sensitive and most specific signals (previously determined at 830 and 860), i.e., that the third signal confirms an occurrence of a pathological state tentatively identified by changes in the most sensitive and most specific signals, then a responsive action may be taken (at 870), as described above.", "This approach may be taken when certainty about the occurrence of a pathologic state is advisable to issue a warning (to avoid undue unwarranted distress to the patient and adoption of unnecessary precautions if a false detection is issued) or delivery of a therapy that while efficacious in preventing or blocking the pathological state may cause certain unsafe or intolerable side effects.", "If no change occurred in the third signal, then the method may return to gathering the most sensitive signal (at 810).", "As the person of ordinary skill in the art will readily understand, the order of elements 810-830 and 840-860 may differ, i.e., the most specific signal may be gathered first and the most sensitive, second.", "FIG.", "9 presents a flowchart depiction of a method 900 according to some embodiments of the present disclosure.", "The method 900 may allow detection of a pathological state in a patient in a highly specific manner.", "A most specific signal may be gathered (at 910) and processed (or analyzed) (at 920), and whether a change in the most specific signal occurred may be determined (at 930).", "If a change in the most specific signal has occurred, i.e., a highly specific indication has arisen that the patient is in a pathological state then a responsive action may be taken (at 940).", "The responsive action may comprise one or more of those described elsewhere herein.", "Choice of a “most” specific signal may simplify the process of detection of pathological states without compromising accuracy.", "If the most specific signal has not undergone a change, then the method may return to gathering the most specific signal (at 910), or one or more other signals may be gathered (at 950), processed (or analyzed) (at 960), and whether a change in the other signal(s) has occurred may be determined (at 930).", "A lack of change in the other signal may indicate that yet another signal may be gathered (at 950), etc., or that the method may return to gathering the most specific signal (at 910).", "An observed change in the other signal (at 970) may render it desirable to discontinue gathering the most specific signal (e.g., the “most specific” signal may turn out to have an undesirably low sensitivity, and gathering of a different signal may be desirable.", "In some embodiments, the present disclosure relates to a method, comprising: gathering a first biological signal or feature thereof from a patient; receiving an indication to gather a second biological signal or feature thereof from the patient; gathering the second biological signal or feature thereof; determining at least one of a sensitivity, a specificity, or a speed of detection of a pathological state in the patient from both the first biological signal or feature thereof and the second biological signal or feature thereof; continuing gathering of the biological signal or feature thereof having a better sensitivity of detection, a better specificity of detection, or a better speed of detection; and stopping gathering of the biological signal or feature thereof having a poorer sensitivity of detection, a poorer specificity of detection, or a poorer speed of detection.", "The methods depicted in FIGS.", "4-9 and/or described above may be governed by instructions that are stored in a non-transitory computer readable storage medium and that are executed by, e.g., a processor 217 of the medical device 200.Each of the operations shown in FIGS.", "4-9 and/or described above may correspond to instructions stored in a non-transitory computer memory or computer readable storage medium.", "In various embodiments, the non-transitory computer readable storage medium includes a magnetic or optical disk storage device, solid state storage devices such as flash memory, or other non-volatile memory device or devices.", "The computer readable instructions stored on the non-transitory computer readable storage medium may be in source code, assembly language code, object code, or other instruction format that is interpreted and/or executable by one or more processors.", "In some embodiments, the present disclosure may relate to one or more of the following numbered paragraphs: 101.A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform a method, comprising: receiving a first indication to gather a first biological signal or feature thereof from a patient; gathering said first biological signal or feature thereof; receiving a second indication to stop gathering said first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping gathering said first biological signal or feature thereof.", "102.The non-transitory computer readable program storage unit of numbered paragraph 101, wherein at least one of said first indication or said second indication is based at least in part on at least one second biological signal or feature thereof from said patient.", "103.The non-transitory computer readable program storage unit of numbered paragraph 101, wherein said first indication is based at least in part on a first feature of said first signal or feature thereof, and said second indication is based at least in part on a first feature of a second biological signal or feature thereof.", "104.The non-transitory computer readable program storage unit of numbered paragraph 101, wherein the first signal or feature thereof is selected from an autonomic signal or feature thereof, a neurologic signal or feature thereof, a metabolic signal or feature thereof, an endocrine signal or feature thereof, or a tissue stress marker signal or feature thereof.", "105.The non-transitory computer readable program storage unit of numbered paragraph 102, wherein the second biological signal or feature thereof is selected from an electrocardiography (EKG) signal or feature thereof or a kinetic signal or feature thereof, and the first biological signal or feature thereof is selected from the other of said EKG signal or feature thereof and kinetic signal or feature thereof, an electroencephalography (EEG) signal or feature thereof, an electrocorticography (ECoG) signal or feature thereof, a reaction time signal or feature thereof, an awareness signal or feature thereof, or a responsiveness signal or feature thereof.", "106.The non-transitory computer readable program storage unit of numbered paragraph 102, wherein said second biological signal or feature thereof is selected from at least one of a cardiac signal or feature thereof, a kinetic signal or feature thereof, or a respiratory signal or feature thereof; said first biological signal or feature thereof is selected from at least one of said cardiac signal or feature thereof, said kinetic signal or feature thereof, and said respiratory signal or feature thereof, provided said first biological signal or feature thereof is different from said second biological signal or feature thereof said first indication is based at least in part on said second biological signal or feature thereof and said first indication is indicative of an epileptic event.", "107.The non-transitory computer readable program storage unit of numbered paragraph 102, wherein the second biological signal or feature thereof is a cortical brain signal or feature thereof and the first biological signal or feature thereof is an electrocardiography (EKG) signal or feature thereof, a respiratory signal or feature thereof, a kinetic signal or feature thereof, a reaction time signal or feature thereof, an awareness signal or feature thereof, or a responsiveness signal or feature thereof.", "108.The non-transitory computer readable program storage unit of numbered paragraph 105, wherein said first indication is an indication of an occurrence of a seizure based on said EKG signal or feature thereof, and said second indication is of an end of said seizure based on said EKG signal or feature thereof.", "109.The non-transitory computer readable program storage unit of numbered paragraph 101, wherein at least one of said first indication or said second indication is based at least in part on at least one exosomatic signal or feature thereof.", "110.The non-transitory computer readable program storage unit of numbered paragraph 105, wherein the at least one exosomatic signal or feature thereof is a time of day signal or feature thereof, a time of month signal or feature thereof, a luminance level signal or feature thereof, an acoustic noise level signal or feature thereof, a temperature signal or feature thereof, a barometric pressure signal or feature thereof, a signal or feature thereof indicative of a physical activity of said patient and when it was performed by said patient, a signal or feature thereof indicative of an attention level of said patient and when said patient was attentive, a signal or feature thereof indicative of a cognitive activity of said patient, the type of cognitive activity and when it was performed by said patient, a signal or feature thereof indicative of a time elapsed since the last seizure of said patient, the last seizure type or class, the last seizure severity of said patient, a signal or feature thereof indicative of a time elapsed since the delivery of a therapy to said patient, the type of therapy and its dose or parameters, the efficacy of said therapy, delivered to said patient, the adverse effects of said therapy and their type and severity, or a signal or feature thereof indicative of a time elapsed since the last caloric intake and its amount, a signal or feature thereof indicative of stress level and when it changes of said patient.", "201.A medical device system, comprising: a first sensor configured to sense a first biological signal or feature thereof from a patient; a signal or feature thereof recorder module configured to record said first biological signal or feature thereof; a signal or feature thereof analysis module configured to analyze said first biological signal or feature thereof; a controller configured to generate a first indication based on a second biological signal or feature thereof to activate at least one of said first sensor, said signal or feature thereof recorder module, or said signal or feature thereof analysis module, such that all of said first sensor, said signal or feature thereof recorder module, and said signal or feature thereof analysis module are activated and to generate a second indication based on said second biological signal or feature thereof to deactivate at least one of said first sensor, said signal or feature thereof recorder module, or said signal or feature thereof analysis module; and a memory configured to store at least said first analyzed biological signal or feature thereof.", "202.The medical device system of numbered paragraph 201, further comprising: a brain state change detection module configured to detect a brain state change, based at least in part on said first biological signal or feature thereof.", "203.The medical device system of numbered paragraph 201, wherein said brain state change is an epileptic seizure.", "204.The medical device system of numbered paragraph 201, wherein said first indication is based on a seizure event onset determined from said second biological signal or feature thereof, and said second indication is based on a seizure event end determined from said second biological signal or feature thereof.", "205.The medical device system of numbered paragraph 201, wherein said first biological signal or feature thereof is an electroencephalography (EEG) signal or feature thereof, an electrocorticography (ECoG) signal or feature thereof, a kinetic signal or feature thereof, a reaction time signal or feature thereof, an awareness signal or feature thereof, or a responsiveness signal or feature thereof.", "206.The medical device system of numbered paragraph 201, wherein said signal or feature thereof analysis module is configured to determine a first feature of said first biological signal or feature thereof, wherein the first feature is one of power in certain frequency band, a rhythmicity index, a waveform morphology, a synchronization level, a direction of a movement, an amplitude of a movement or an acceleration of a movement.", "207.The medical device system of numbered paragraph 201, further comprising: a second sensor configured to sense a second biological signal or feature thereof from said patient; wherein said controller is configured to generate at least one of said first indication or said second indication based at least in part on said second biological signal or feature thereof.", "208.The medical device system of numbered paragraph 207, wherein said second biological signal or feature thereof is an electrocardiography (EKG) signal or feature thereof.", "209.The medical device system of numbered paragraph 201, wherein said first biological signal or feature thereof is an electrocardiography (EKG) signal or feature thereof and said signal or feature thereof analysis module is configured to determine a first feature of said first biological signal or feature thereof, wherein said first feature is one of heart rate, heart rate variability, EKG morphology, heart rhythm, or Q-T interval.", "210.The medical device system of numbered paragraph 201, wherein said controller is configured to generate at least one of said first indication or said second indication based at least in part on at least one exosomatic signal or feature thereof.", "211.The medical device system of numbered paragraph 210, wherein the at least one exosomatic signal or feature thereof is a time of day signal or feature thereof, a time of month signal or feature thereof, a luminance level signal or feature thereof, an acoustic noise level signal or feature thereof, a temperature signal or feature thereof, a barometric pressure signal or feature thereof, a signal or feature thereof indicative of a physical activity of said patient and when it was performed by said patient, a signal or feature thereof indicative of an attention level of said patient and when said patient was attentive, a signal or feature thereof indicative of a cognitive activity of said patient, the type of cognitive activity and when it was performed by said patient, a signal or feature thereof indicative of a time elapsed since the last seizure of said patient, the last seizure type or class, the last seizure severity of said patient, a signal or feature thereof indicative of a time elapsed since the delivery of a therapy to said patient, the type of therapy and its dose or parameters, the efficacy of said therapy, delivered to said patient, the adverse effects of said therapy and their type and severity, or a signal or feature thereof indicative of a time elapsed since the last caloric intake and its amount, a signal or feature thereof indicative of stress level and when it changes of said patient." ] ]
Patent_15874352
[ [ "Additive Manufacturing Process", "An additive manufacturing method.", "The method includes mixing a reflective material including fibers with a photopolymer resin to form a resin mixture having a loading of the reflective material of at least 3 wt.", "%.", "The method further includes curing the resin mixture using a light source to form first and second individually cured layers and a bridge of a portion of the fibers between the two layers." ], [ "1.An additive manufacturing method, comprising: mixing a reflective material including fibers with a photopolymer resin to form a resin mixture having a loading of the reflective material of at least 3 wt.", "%; and curing the resin mixture using a light source to form first and second individually cured layers and a bridge of a portion of the fibers between the first and second layer.", "2.The method of claim 1, wherein the light source has a wavelength of at least 350 nm.", "3.The method of claim 1, wherein the light source has a wavelength of 375 to 425 nm.", "4.The method of claim 1, wherein the reflective material reflects at least 80% of the visible light spectrum.", "5.The method of claim 1, wherein the reflective material reflects at least 95% of the visible light spectrum.", "6.The method of claim 1, wherein the reflective material includes cellulose fibers.", "7.The method of claim 1, wherein the fibers have a length of 5-250 μm.", "8.The method of claim 1, wherein the reflective material includes talc powder.", "9.The method of claim 1, wherein the reflective material includes soy flour.", "10.An additive manufacturing method, comprising: mixing cellulose fibers with a photopolymer resin to form a resin mixture having a loading of the cellulose fibers of at least 3 wt.", "%; and curing the resin mixture using a light source to form first and second individually cured layers and a bridge of a portion of the cellulose fibers between the first and second layers.", "11.The method of claim 10, wherein the resin mixture further includes a filler composition.", "12.The method of claim 10, wherein the cellulose fibers have a length of at least 5 μm.", "13.The method of claim 10, wherein the cellulose fibers have a diameter of at least 0.5 μm.", "14.The method of claim 10, wherein the cellulose fibers have a length of 5-25 μm.", "15.The method of claim 10, wherein the cellulose fibers are plant-based cellulose fibers.", "16.An additive manufacturing method, comprising: mixing cellulose fibers with a photopolymer resin to form a resin mixture having a loading of the cellulose fibers of at least 3 wt.", "%; and curing the resin mixture using a light source to form first and second individually cured layers and a link of a portion of the cellulose fibers between the two first and second layers.", "17.The method of claim 16, wherein the cellulose fibers have a length of at least 5 μm.", "18.The method of claim 16, wherein the cellulose fibers have a diameter of at least 0.5 μm.", "19.The method of claim 16, wherein the cellulose fibers have a length of 5-25 μm.", "20.The method of claim 16, wherein the cellulose fibers are plant-based cellulose fibers." ], [ "<SOH> BACKGROUND <EOH>Additive manufacturing, also referred to as 3D printing, is a manufacturing process that allows for layer-by-layer fabrication of a component.", "There are numerous types of additive manufacturing processes, which may use inkjet-style printers, laser curing/sintering, light-based curing, or other techniques.", "One additive manufacturing process, known as stereolithography, may use ultraviolet (UV) light to photopolymerize a liquid resin one layer at a time to build-up a component.", "While additive manufacturing can be very cost and time effective for producing one part or a small number of parts, its cycle time is generally considerably slower than typical mass production processes, such as injection molding." ], [ "<SOH> SUMMARY <EOH>In at least one embodiment, an additive manufacturing method is disclosed.", "The method includes mixing a reflective material including fibers with a photopolymer resin to form a resin mixture having a loading of the reflective material of at least 3 wt.", "%.", "The method further includes curing the resin mixture using a light source to form first and second individually cured layers and a bridge of a portion of the fibers between the two layers.", "In one embodiment, an additive manufacturing method is disclosed.", "The method includes mixing cellulose fibers with a photopolymer resin to form a resin mixture having a loading of the cellulose fibers of at least 3 wt.", "%; and curing the resin mixture using a light source to form first and second individually cured layers and a bridge of a portion of the cellulose fibers between the two layers.", "In another embodiment, an additive manufacturing method is disclosed.", "The method includes mixing cellulose fibers with a photopolymer resin to form a resin mixture having a loading of the cellulose fibers of at least 3 wt.", "%; and curing the resin mixture using a light source to form first and second individually cured layers and a link of a portion of the cellulose fibers between the two layers." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "15/352,072 filed Nov. 15, 2016, and issued as U.S. Pat.", "No.", "______ on ______, the disclosure of which is hereby incorporated in its entirety by reference herein.", "TECHNICAL FIELD The present disclosure relates to an additive manufacturing method using a resin mixture with reflective fibers.", "BACKGROUND Additive manufacturing, also referred to as 3D printing, is a manufacturing process that allows for layer-by-layer fabrication of a component.", "There are numerous types of additive manufacturing processes, which may use inkjet-style printers, laser curing/sintering, light-based curing, or other techniques.", "One additive manufacturing process, known as stereolithography, may use ultraviolet (UV) light to photopolymerize a liquid resin one layer at a time to build-up a component.", "While additive manufacturing can be very cost and time effective for producing one part or a small number of parts, its cycle time is generally considerably slower than typical mass production processes, such as injection molding.", "SUMMARY In at least one embodiment, an additive manufacturing method is disclosed.", "The method includes mixing a reflective material including fibers with a photopolymer resin to form a resin mixture having a loading of the reflective material of at least 3 wt.", "%.", "The method further includes curing the resin mixture using a light source to form first and second individually cured layers and a bridge of a portion of the fibers between the two layers.", "In one embodiment, an additive manufacturing method is disclosed.", "The method includes mixing cellulose fibers with a photopolymer resin to form a resin mixture having a loading of the cellulose fibers of at least 3 wt.", "%; and curing the resin mixture using a light source to form first and second individually cured layers and a bridge of a portion of the cellulose fibers between the two layers.", "In another embodiment, an additive manufacturing method is disclosed.", "The method includes mixing cellulose fibers with a photopolymer resin to form a resin mixture having a loading of the cellulose fibers of at least 3 wt.", "%; and curing the resin mixture using a light source to form first and second individually cured layers and a link of a portion of the cellulose fibers between the two layers.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a schematic example of a stereolithography (SLA) additive manufacturing process; FIG.", "2 is a flowchart of a method of accelerating the cure time of a resin in an additive manufacturing process, according to an embodiment; FIG.", "3 is a photograph of cure dosage test samples of prototyping resin including cellulose fibers; and FIG.", "4 is experimental data showing that several reflective materials reduce the cure time of photopolymer resins exposed to UV light.", "DETAILED DESCRIPTION As required, detailed embodiments of the present invention are disclosed herein; however, it is to be understood that the disclosed embodiments are merely exemplary of the invention that may be embodied in various and alternative forms.", "The figures are not necessarily to scale; some features may be exaggerated or minimized to show details of particular components.", "Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a representative basis for teaching one skilled in the art to variously employ the present invention.", "With reference to FIG.", "1, an example of an additive manufacturing system 10 is shown.", "Additive manufacturing may also be referred to as 3D printing or rapid prototyping.", "There are numerous types of additive manufacturing processes, which may use inkjet-style printers, laser curing/sintering, light-based curing, or other techniques.", "In general, additive manufacturing includes a layer-by-layer build-up of a component, rather than forming a component in one single step (e.g., casting or injection molding).", "Additive manufacturing allows for custom manufacturing of components without significant changes in tools or equipment, since the layer-by-layer building instructions can be stored in software instead of hardware.", "While additive manufacturing can be very cost and time effective for producing one part or a small number of parts, its cycle time is generally considerably slower than typical mass production processes, such as injection molding.", "One additive manufacturing process, known as stereolithography (SLA), may use ultraviolet (UV) light to photopolymerize a liquid resin one layer at a time to build-up a component.", "The system 10 is an example of an SLA system, however, it is to be understood that SLA systems may have multiple designs and the specific components and/or functions described herein are not intended to be limiting.", "One of ordinary skill in the art will understand that, based on the present disclosure, modifications or adjustments to the SLA system may be made.", "In addition, the present disclosure is applicable to additive manufacturing techniques in general, with SLA merely being an example.", "Accordingly, one of ordinary skill in the art will understand that the present disclosure may be adapted to be used in any type of additive manufacturing technique.", "The system 10 may include a container, tank, or vat 12 of liquid resin 14.The liquid resin 14 may be any resin that is curable by light, such as ultraviolet (UV) or visible light.", "A support plate or platform 16 may be positioned within the vat 12 and may be configured to move vertically within the vat 12 and resin 14.In some embodiments, the platform 16 may be movable in additional directions, for example, in the X-Y plane in addition to the Z direction.", "The system 10 may also include a light source 18 that is configured to shine or trace an image or pattern onto a top surface 20 of the liquid resin 14.In the embodiment shown, the light source 18 is a laser.", "The laser may trace a pattern onto the top layer 20 of the resin 14 by scanning across the surface in a path controlled by a controller (e.g., with instructions stored in/implemented by software).", "The laser may directly contact the top layer 20, or there may be one or more optical devices 22 (e.g., mirrors) positioned to reflect or guide the laser.", "When the laser beam 24 contacts the top layer 20 of the liquid resin 14, the resin may be cured or solidified into a solid polymer.", "This process may be referred to as photopolymerization.", "Accordingly, by tracing a pattern on the top layer 20 of the resin with the laser, a solid layer 26 of a component 28 may be formed.", "The solid layer 26 corresponds to a cross-section of the component having a certain thickness.", "When one layer has been completed, the platform 16 may be lowered in the vat 12 such that a new top layer 20 of liquid resin 14 covers the solid layer 26 that was just formed.", "A new solid layer 26 may then be formed by tracing a pattern with the laser.", "This process may be repeated until a completed component 28 is formed having a plurality of solid layers 26 stacked in the Z-direction.", "As described above, SLA systems may have a variety of designs, and the system 10 is merely one example.", "A person of ordinary skill in the art will understand that variations or modifications of the system 10 may be used in accordance with the present disclosure.", "For example, while the system 10 is shown and described with the component 28 moving downward after each layer 26 is solidified, some systems may do the opposite.", "In some designs, the part may be moved upward after each layer is solidified from the bottom.", "In these designs, there may be a transparent window in the bottom of the vat to allow a light source to travel therethrough and solidify a bottom layer of liquid resin in the vat.", "The component may then be raised and a new layer of liquid resin is formed in the bottom of the vat.", "In addition, light sources other than a laser may be used.", "For example, light (e.g., UV light) may be projected onto the liquid resin in a two-dimensional (2D) image such that it solidifies the resin in the layer all at once.", "Additive manufacturing techniques, such as SLA, are generally quite cost and time efficient for making prototype parts or for very low volume production runs, since they do not require new tooling and equipment for each design iteration.", "However, additive manufacturing is generally not competitive with traditional high-volume manufacturing processes, particularly for plastic parts, such as injection molding, compression molding, blow molding, etc., because the latter have very short cycles times per part (e.g., less than 30 seconds).", "In an attempt to reduce cycle times, additional components have been added to the polymer resins to improve (reduce) their cure times.", "For example, reactive diluents, such as vinyl compounds, may be added to speed up the curing process.", "However, the addition of these accelerators may have drawbacks, such as increased resin toxicity, heat generation, and/or local viscosity changes within the resin during printing.", "In addition to diluents (if present), light-curable resins, or photopolymers, may include photoinitiators, which are molecules that creates reactive species (free radicals, cations or anions) when exposed to radiation (e.g., UV or visible light).", "The resins may also include pigments to give the polymer a certain color.", "Another byproduct of the layer-by-layer production in additive manufacturing is the potential for anisotropic properties in the finished component.", "Because each layer in the component cures separately, the mechanical properties in the print direction (e.g., Z-direction in FIG.", "1) may be lower than the in-plane or in-layer direction (e.g., X-Y plane).", "Without being held to any particular theory, it is believed that the separate curing of each layer may reduce the adhesion strength between layers.", "This may lead to delamination or fracturing/failure of the component at lower loads.", "In an attempt to overcome this anisotropic property of the additive manufacturing process, Applicant theorized that adding fibers to the polymer resin may improve the adhesion strength between the layers and reduce the anisotropy of the mechanical properties.", "It was believed that the fibers may form a link or bridge between the two layers and improve the strength of the interlayer adhesion.", "For example, if a portion of the fibers from a first layer are exposed following the curing of the layer and a new layer is solidified around the exposed fiber portions, the fibers may provide a bridge between the two layers.", "While investigating the potential mechanical property benefits of adding fibers to a photopolymer resin, testing was performed to determine the cure dosage of the resins having cellulose fibers included therein.", "The cure dosage may be defined as the amount of light or light energy needed to cure a certain amount of the resin.", "During this testing, it was surprisingly discovered that the addition of the cellulose fibers significantly reduced the cure time of the resin.", "Without being held to any particular theory, several potential explanations for the reduced cure time have been developed.", "One potential explanation is that the cellulose fibers act to reflect the light (e.g., UV or visible light) within the liquid resin during the photopolymerization process.", "In general, when the light source is applied to the liquid resin in the additive manufacturing process (e.g., SLA), the light is coming from a single direction that is generally perpendicular to the layer of liquid resin.", "The light then travels into/through the resin in only this direction.", "It is believed that the cellulose fibers may cause some of the light entering the liquid resin to reflect or scatter in a different direction.", "This reflection of the light may cause more of the light energy to be absorbed by the resin and used to cure it.", "A second potential explanation may be that the cellulose fibers displace a portion of the resin that would otherwise need to be cured by the light.", "A reduction in the amount of resin that needs to be cured may therefore reduce the total cure time for a given component.", "While this mechanism may play a role in the reduced cure time, it is believed that it is not the sole mechanism.", "As will be described in greater detail below, several different materials were independently added to the resin and resulted in reductions of the curing time by a significant amount, even at relatively low concentrations by weight.", "In several of the materials tested, the reductions in cure time on a percentage basis were much greater than the weight percent of the resin that was displaced.", "It therefore stands to reason that displacement was not the only mechanism involved.", "In addition, one material that was tested, graphene, actually increased the cure time of the resin.", "It is believed that graphene may have hindered the cure time because it is black, and therefore absorbs visible light.", "By absorbing the light energy from the light source, there may have been less available to cure the resin.", "This behavior appears to support the first potential explanation, that the cellulose, which is white, reflects some of the light energy and therefore speeds the curing time of the liquid resin.", "To support this theorized explanation, several additional white or near-white materials were tested: soy flour and talc powder.", "Both materials also improved the cure time of the photopolymer resin, increasing the plausibility of the reflective theory.", "In at least one embodiment, a method is provided in which a material is mixed with a photopolymer resin to reduce the cure time of the resin.", "The material may be mixed with the photopolymer resin prior to introducing it into the vat.", "In one embodiment, the material may be white or near-white in color.", "As used herein, a material that is white may be a material that reflects all or substantially all visible light.", "A near-white material may be a material that reflects most visible light, for example, at least 75%, 80%, 85%, 90%, or 95% of the visible light spectrum.", "These materials may appear to be off-white or slightly yellow/beige.", "The materials disclosed herein, cellulose fibers, talc powder, and soy flour, all meet this definition of white or near-white.", "While these three white/near-white materials have been tested and found to be effective at reducing cure times, the present disclosure is not intended to be limited to these materials.", "Instead, it is contemplated that any suitable additive or filler that is white or near-white in color may have a similar effect.", "The magnitude of the effect may vary depending on the material used and its properties (e.g., geometry, material properties, surface finish, etc.).", "These materials may be referred to as light reflective materials.", "In general, it has been found that the reduction in cure time improves with additional loading of the light reflective materials.", "Stated another way, as the loading of the light reflective materials increases, the cure time of the photopolymer decreases.", "The quantity of the light reflective material that may be included in the resin may vary depending on the material used, its geometric properties, the composition of the resin, the constraints of the particular additive manufacturing process being used, or others.", "For example, in certain additive manufacturing processes, the viscosity of the liquid resin may be a limiting factor on the loading of the reflective material.", "In one example, it was found that high-aspect ratio cellulose fibers (e.g., 200+ μm in length) had a practical limit of about 5 wt.", "% in an SLA process before the viscosity began to be too high.", "Other materials or geometries may have significantly higher weight fractions before adversely affecting the viscosity, however.", "For example, lower-aspect ratio cellulose fibers (e.g., 8 μm in length) were able to be loaded at upwards of 20 wt.", "% in certain resins while still being able to be produced/printed.", "In at least one embodiment, one or more reflective materials (e.g., cellulose fibers, talc powder, or soy flour) may be included in a photopolymer resin at a total loading of at least 2% by weight, for example, at least 5%, 8%, 10%, 15%, or 20% by weight.", "In another embodiment, the reflective material may be included in a photopolymer resin at a loading of 2-20% by weight, or any sub-range therein, such as 3-20%, 4-20%, 5-20%, 8-20%, 10-20%, 3-15%, 3-10%, 5-15%, 5-10%, or others.", "If more than one reflective material is used, the composition may be evenly split among the different reflective materials.", "For example, if there are two reflective materials, the overall composition of the reflective material may be a 50/50 split by weight.", "However, there may be any distribution of the reflective materials, such as 60/40, 70/30, 80/20, 90/10 or others.", "The reflective material(s) may be considered a filler material.", "A filler material may be defined as any material that is not the base photopolymer resin (e.g., the bulk polymer), a photoinitiator, or a pigment (optional).", "For example, for a polyurethane resin, the primary or base ingredients may include polyol, diisocyanate, acrylate blocking unit, chain extender (e.g., diamine), diluent, photoinitiator, dye.", "Any additives in addition to these components may be considered fillers.", "In one embodiment, the reflective material or materials may be the only filler material in the total photopolymer resin composition or substantially the only filler (e.g., at least 99 wt/vol.", "%).", "In another embodiment, the reflective material(s) may comprise at least 50% of the total filler loading by weight or by volume, for example, at least 60%, 70%, 80%, 90%, or 95%.", "In one embodiment, the total filler loading in the resin may be at most 25% by weight or by volume, for example, at most 20% or 15%.", "Accordingly, the reflective material(s) may account for all, or close to all, of the total filler loading.", "Other filler materials may increase the viscosity of the resin to unacceptable levels and/or counteract the reduction in cure time provided by the reflective materials(s).", "In at least one embodiment, cellulose fibers may be included in the photopolymer resin.", "Cellulose fibers may be made with ether or esters of cellulose, which may be obtained from plant-based material, such as bark, wood, or leaves.", "As described above, cellulose is white in color.", "The cellulose fibers may be natural or manufactured.", "In one embodiment, the fibers may have a length (e.g., on a long axis) of at least 3 μm, for example, at least 5 μm or at least 8 μm.", "In another embodiment, the fibers may have a length of 3-500 μm, or any sub-range therein, such as 3-250 μm, 5-250 μm, 3-50 μm, 3-25 μm, 3-10 μm, 5-25 μm, 5-10 μm, 100-500 μm, 100-300 μm, 150-250 μm, or others.", "However, cellulose fibers having lengths smaller or larger than those disclosed may also be used.", "The width of the fibers may be less than the length of the fibers (e.g., such that there is an aspect ratio of >1).", "In one embodiment, the fibers may have a diameter or width of 0.1-50 μm, or any sub-range therein, such as 0.3-50 μm, 0.5-50 μm, 1-50 μm, 0.5-35 μm, 1-35 μm, 0.5-20 μm, 1-20 μm, 0.5-10 μm, 1-10 μm, or others.", "In another embodiment, the fibers may have a diameter of less than 35 μm, 20 μm, 10 μm, or 5 μm.", "In another embodiment, the fibers may have a diameter of at least 0.3 μm, 0.5 μm, 1 μm, 5 μm, or 10 μm.", "However, cellulose fibers having widths smaller or larger than those disclosed may also be used.", "In at least another embodiment, talc may be included in the photopolymer resin.", "The talc may be included as a powder.", "Talc is a clay mineral composed of hydrated magnesium silicate.", "As described above, talc/talc powder is white in color.", "The talc powder may have an average particle size of 1-200 μm, or any sub-range therein, such as 1-100 μm or 1-50 μm.", "In at least another embodiment, soy flour may be included in the photopolymer resin.", "Soy four is formed from soybeans.", "Soy flour may be formed by grinding soybeans into a fine powder, for example, fine enough to pass through a 100-mesh or smaller screen (e.g., <150 μm average particle size).", "As described above, talc/talc powder may be white or near-white in color.", "Cellulose fibers and soy flour are both organic materials, while talc powder is inorganic.", "Accordingly, the reflective materials may be either organic or inorganic (or both, if multiple are used).", "Additive manufacturing techniques, such as SLA, may use a light source to cure or photopolymerize a polymer resin.", "In some embodiments, the light source may be a visible light source or a UV light source.", "Visible light has a wavelength of about 400 to 700 nm, while UV light has a wavelength of about 10 to 400 nm.", "As described above, it is believed that white or near-white materials may reflect at least a portion of the light that hits the material, thereby reducing the cure time of the resin.", "It is believed that the reflective materials may be particularly effective for UV light that is near the visible light wavelength in the spectrum (e.g., close to 400 nm).", "Accordingly, in at least one embodiment, a UV source that emits light having a wavelength of at least 350 nm may be used in conjunction with resin including the reflective material(s).", "For example, the UV source may emit light having a wavelength of at least 375 nm.", "In one embodiment, the UV source may emit light having a wavelength of 350-425 nm, or any sub-range therein, such as 375-425 nm, 375-400 nm, or 380-400 nm.", "In one embodiment, the wavelength of the light may be about 385 nm (e.g., ±5 nm).", "The present disclosure is applicable to all photopolymers (e.g., those cured by light or other electromagnetic radiation).", "In some embodiments, the reflective material(s) may be included in so-called prototyping resins, which generally have relatively fast cure times but relatively poor mechanical properties.", "Prototyping resins may be used to create prototypes for visual, spatial, or proof-of-concept purposes, but that do not typically go into production or commercial use.", "Examples of classes of prototyping resins may include polyurethane based resins (e.g., polyurethane acrylates) or cyanate ester based resins.", "However, the reflective material(s) may also be included in other resin types, including those that are used to create production or commercial-level components.", "Indeed, reduced cure times may be more beneficial to these resins, since cycle time is currently a drawback to large-scale production by additive manufacturing.", "In one embodiment, the disclosed reflective material(s) may be used in engineering resins, which may be those having mechanical properties suitable for production/commercial parts.", "Some engineering resins may have two-part formulations, including a base resin and a hardener or curing agent.", "Once mixed together, the liquid resin may have a predetermined time period before it hardens.", "In additive manufacturing, two-part resins may have a limited time in which to “print” the mixed resin before it becomes too viscous or solid.", "This time may be referred to as a pot life.", "Accordingly, if an additive manufacturing process includes a vat of mixed two-part resin, the size of the printed object may be limited by the cure time of the resin.", "If the cure time is reduced, such as through the addition of reflective materials, a larger part may be printed before the pot life runs out.", "With reference to FIG.", "2, an example flowchart 100 is shown for a method of accelerating the cure time of an additive manufacturing process.", "The flowchart 100 reflects the processes and steps described above.", "In step 102, an accelerating material may be added to a photopolymer resin.", "The accelerating material may be a material that reflects most or all of the visible spectrum of light (e.g., a white or near-white material).", "For example, the material may be cellulose fibers, talc powder, soy flour, or other materials.", "In step 104, the resin having the accelerating material mixed in may be introduced into a vat, pot, cartridge, or other container associated with an additive manufacturing process.", "For example, in an SLA process, the mixed resin may be introduced into a vat and in a 3D printing process it may be introduced into a printing cartridge or container connected to a nozzle/needle.", "In step 106, a layer of the mixed resin may be cured.", "In some embodiments, the curing may be performed using electromagnetic radiation (e.g., a type of light).", "In one embodiment, the EM radiation may be ultraviolet (UV) light or visible light.", "In other embodiments, the curing may be performed by heat or allowing the resin to cure naturally (e.g., at ambient conditions).", "In an SLA process, the mixed resin may be cured by exposing a top or bottom surface of the mixed resin to UV or visible light.", "For example, a laser may trace a pattern on the surface or a 2D shape may be projected onto the surface using a bulb or lamp.", "In step 108, the curing process of step 106 may be repeated one or more times to build-up an article or component in a layer-by-layer process (additive manufacturing).", "The number of times the curing step is repeated may depend on the component being formed and the particular properties of the additive manufacturing technique.", "The accelerating material may reduce the time the resin takes to cure in step 106, which may allow the repeating of step 106 to take place in a shorter amount of time.", "EXAMPLES With reference to FIG.", "3, examples are shown of multiple cure dosage dots that were printed using SLA.", "As described above, the cure time reducing effect of the cellulose fibers was discovered while determining the cure dosage of the resin including the cellulose fibers.", "FIG.", "3 shows examples of cure dosage test dots for a polyurethane acrylate resin with 1 wt.", "% cellulose fibers included (200 μm fibers).", "With reference to FIG.", "4, cure time data is shown for a number of different reflective materials and loadings.", "Two different polyurethane acrylate resin compositions were used, both were prototyping resins supplied by Carbon3D, Inc.", "The resins will be referred to as RP1 and RP2.As shown in the graph, the cure times of RP1 and RP2 without any reflective filler material are about 0.76 seconds and about 0.43 seconds, respectively.", "Varying loads of cellulose fibers (two different lengths), talc powder, and soy flour were added to each resin and the cure times were tested to determine the effect of the reflective materials.", "As shown, each of the materials reduced the cure time of RP1 and both cellulose fiber sizes reduced the cured time of RP2 (only cellulose was tested).", "In addition, each material reduced the cure time to a greater degree with increased loading.", "Loadings of 5 wt.", "% of 200 μm cellulose fiber reduced the cure time of RP1 from 0.76 seconds to 0.56 seconds and the cure time of RP2 from 0.43 seconds to 0.3 seconds, an approximately 24% and 30% reduction, respectively.", "The 8 μm cellulose fibers were tested at various loads in the RP1 resin up to 20 wt.", "%.", "At 5 wt.", "%, the cure time was reduced to 0.47 seconds (˜38% reduction), at 10 wt.", "% it was reduced to 0.41 seconds (˜46% reduction), and at 20 wt.", "% it was reduced to 0.28 seconds (˜63% reduction).", "The 8 μm cellulose fibers were tested at several relatively low loads in the RP2 resin.", "Despite the lower loads, the 8 μm cellulose fibers still reduced the cure time by about 17% (0.5 wt.", "%), 22% (1.0 wt.", "%), and 26% (2.5 wt.", "%).", "Accordingly, both cellulose fiber types were able to substantially reduce the cure times of both resins.", "Significantly, the decreased cure times were disproportionately higher than the amount of displaced resin.", "The talc powder and the soy flour were each tested at two different loadings in the RP1 resin.", "The results were similar for both materials, with soy flour causing a slightly larger decrease in the cure time.", "Talc powder reduced the cure time by about 3% at a 2 wt.", "% loading and 18% at a 7.5 wt.", "% loading.", "Soy flour reduced the cure time by about 7% at a 2 wt.", "% loading and 20% at a 7.5 wt.", "% loading.", "Accordingly, both talc powder and soy flour were able to reduce the cure times of the RP1 resin.", "The cure times were disproportionately higher than the amount of displaced resin, particularly at higher loadings.", "While exemplary embodiments are described above, it is not intended that these embodiments describe all possible forms of the invention.", "Rather, the words used in the specification are words of description rather than limitation, and it is understood that various changes may be made without departing from the spirit and scope of the invention.", "Additionally, the features of various implementing embodiments may be combined to form further embodiments of the invention." ] ]
Patent_15874362
[ [ "Method and Apparatus for Managing Touch Functionality in a Repetitively Flexible Device", "A method, information handling system, and display assembly utilizes wherein a first touch panel indication is detected, and it is determined whether the first touch panel indication is from a defined bending area or from a defined non-bending area.", "When the first touch panel indication is from the defined bending area, it is determined if there is a second touch panel indication from an other touch sensor element adjacent to the first touch sensor element.", "When there is a simultaneous second touch panel indication, the touch location is interpolated based on the locations of the first and the other touch sensor elements.", "When there is a sequential second touch panel indication, the touch location is extrapolated based on locations of the first and the other touch sensor elements and a sequence of the first touch panel indication and the second touch panel indication." ], [ "1.A method comprising: receiving outputs generated by touch sensors associated with a touch panel display, the touch sensors generating the outputs responsive to a touch input to the touch panel display; determining that the touch sensors are located along a bendable spine of the touch panel display; interpolating a location associated with the touch input in response to the outputs generated substantially simultaneously along the bendable spine of the touch panel display; and extrapolating the location associated with the touch input in response to the outputs generated sequentially along the bendable spine of the touch panel display.", "2.The method of claim 1 , further comprising determining locations associated with the touch sensors.", "3.The method of claim 2, wherein the interpolating of the location associated with the touch input is based on the locations associated with the touch sensors.", "4.The method of claim 1, further comprising determining the location associated with the touch input is outside the bendable spine of the touch panel display.", "5.The method of claim 1, further comprising determining the location associated with the touch input is opposite one of the touch sensors.", "6.The method of claim 1, further comprising determining the touch panel display is folded based on the outputs generated by the touch sensors.", "7.The method of claim 1, further comprising determining the touch panel display is flat based on the outputs generated by the touch sensors.", "8.An information handling system comprising: a processor; a display assembly coupled to the processor, the display assembly including a bendable spine separating a rigid non-bending front cover from a rigid non-bending back cover; and a memory device storing instructions that when executed cause the processor to perform operations, the operations including: receiving outputs generated by touch sensors associated with the display assembly, the touch sensors generating the outputs responsive to a touch input to the display assembly; determining that the touch sensors are located along a bendable spine of the touch panel display; interpolating a location associated with the touch input in response to the outputs generated substantially simultaneously along the bendable spine; and extrapolating the location associated with the touch input in response to the outputs generated sequentially along the bendable spine.", "9.The information handling system of claim 8, wherein the operations further include determining locations associated with the touch sensors.", "10.The information handling system of claim 9, wherein the operations further include basing the interpolating of the location associated with the touch input on the locations associated with the touch sensors.", "11.The information handling system of claim 8, wherein the operations further include determining the location associated with the touch input is outside the bendable spine of the touch panel display.", "12.The information handling system of claim 8, wherein the operations further include determining the location associated with the touch input is opposite one of the touch sensors.", "13.The information handling system of claim 8, wherein the operations further include determining the touch panel display is folded based on the outputs generated by the touch sensors.", "14.The information handling system of claim 8, wherein the operations further include determining the touch panel display is flat based on the outputs generated by the touch sensors.", "15.A memory device storing instructions that when executed cause a hardware processor to perform operations, the operations comprising: receiving outputs generated by touch sensors associated with a display assembly, the touch sensors generating the outputs responsive to a touch input to the display assembly; determining the touch sensors are located along a bendable spine of the touch panel display that separates a rigid non-bending front cover and a rigid non-bending back cover; interpolating a location associated with the touch input in response to the outputs generated substantially simultaneously along the bendable spine; and extrapolating the location associated with the touch input in response to the outputs generated sequentially along the bendable spine.", "16.The memory device of claim 15, wherein the operations further include determining locations associated with the touch sensors.", "17.The memory device of claim 16, wherein the operations further include basing the interpolating of the location associated with the touch input on the locations associated with the touch sensors.", "18.The memory device of claim 15, wherein the operations further include determining the location associated with the touch input is outside the bendable spine of the touch panel display.", "19.The memory device of claim 15, wherein the operations further include determining the location associated with the touch input is opposite one of the touch sensors.", "20.The memory device of claim 15, wherein the operations further include determining the touch panel display is at least one of i) folded based on the outputs generated by the touch sensors and ii) flat based on the outputs generated by the touch sensors." ], [ "<SOH> BACKGROUND <EOH>As the value and use of information continues to increase, individuals and businesses seek additional ways to process and store information.", "One option is an information handling system.", "An information handling system generally processes, compiles, stores, or communicates information or data for business, personal, or other purposes.", "Technology and information handling needs and requirements can vary between different applications.", "Thus information handling systems can also vary regarding what information is handled, how the information is handled, how much information is processed, stored, or communicated, and how quickly and efficiently the information can be processed, stored, or communicated.", "The variations in information handling systems allow information handling systems to be general or configured for a specific user or specific use such as financial transaction processing, airline reservations, enterprise data storage, or global communications.", "In addition, information handling systems can include a variety of hardware and software resources that can be configured to process, store, and communicate information and can include one or more computer systems, graphics interface systems, data storage systems, networking systems, and mobile communication systems.", "Information handling systems can also implement various virtualized architectures.", "Data and voice communications among information handling systems may be via networks that are wired, wireless, or some combination." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>It will be appreciated that for simplicity and clarity of illustration, elements illustrated in the Figures are not necessarily drawn to scale.", "For example, the dimensions of some elements may be exaggerated relative to other elements.", "Embodiments incorporating teachings of the present disclosure are shown and described with respect to the drawings herein, in which: FIG.", "1 is a block diagram illustrating an information handling system according to an embodiment of the present disclosure; FIG.", "2 is a plan view diagram illustrating an information handling system in a flat physical configuration according to an embodiment of the present disclosure; FIG.", "3 is a perspective view diagram illustrating an information handling system in a flexed physical configuration according to an embodiment of the present disclosure; FIG.", "4 is a perspective view diagram illustrating an information handling system in a folded physical configuration according to an embodiment of the present disclosure; FIG.", "5 is flow diagram illustrating a method according to an embodiment of the present disclosure; FIG.", "6 is flow diagram illustrating a method according to an embodiment of the present disclosure; and FIG.", "7 is flow diagram illustrating a method of manufacture according to an embodiment of the present disclosure.", "FIG.", "8 is an elevation view diagram illustrating a display assembly according to an embodiment of the present disclosure.", "detailed-description description=\"Detailed Description\" end=\"lead\"?", "The use of the same reference symbols in different drawings indicates similar or identical items." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation of U.S. patent application Ser.", "No.", "14/517,151 entitled “Method and Apparatus for Managing Touch Functionality in a Repetitively Flexible Device,” filed on Oct. 17, 2014, the disclosure of which is hereby expressly incorporated by reference in its entirety.", "FIELD OF THE DISCLOSURE The present disclosure generally relates to information handling systems, and more particularly relates to managing touch functionality in a repetitively flexible device.", "BACKGROUND As the value and use of information continues to increase, individuals and businesses seek additional ways to process and store information.", "One option is an information handling system.", "An information handling system generally processes, compiles, stores, or communicates information or data for business, personal, or other purposes.", "Technology and information handling needs and requirements can vary between different applications.", "Thus information handling systems can also vary regarding what information is handled, how the information is handled, how much information is processed, stored, or communicated, and how quickly and efficiently the information can be processed, stored, or communicated.", "The variations in information handling systems allow information handling systems to be general or configured for a specific user or specific use such as financial transaction processing, airline reservations, enterprise data storage, or global communications.", "In addition, information handling systems can include a variety of hardware and software resources that can be configured to process, store, and communicate information and can include one or more computer systems, graphics interface systems, data storage systems, networking systems, and mobile communication systems.", "Information handling systems can also implement various virtualized architectures.", "Data and voice communications among information handling systems may be via networks that are wired, wireless, or some combination.", "BRIEF DESCRIPTION OF THE DRAWINGS It will be appreciated that for simplicity and clarity of illustration, elements illustrated in the Figures are not necessarily drawn to scale.", "For example, the dimensions of some elements may be exaggerated relative to other elements.", "Embodiments incorporating teachings of the present disclosure are shown and described with respect to the drawings herein, in which: FIG.", "1 is a block diagram illustrating an information handling system according to an embodiment of the present disclosure; FIG.", "2 is a plan view diagram illustrating an information handling system in a flat physical configuration according to an embodiment of the present disclosure; FIG.", "3 is a perspective view diagram illustrating an information handling system in a flexed physical configuration according to an embodiment of the present disclosure; FIG.", "4 is a perspective view diagram illustrating an information handling system in a folded physical configuration according to an embodiment of the present disclosure; FIG.", "5 is flow diagram illustrating a method according to an embodiment of the present disclosure; FIG.", "6 is flow diagram illustrating a method according to an embodiment of the present disclosure; and FIG.", "7 is flow diagram illustrating a method of manufacture according to an embodiment of the present disclosure.", "FIG.", "8 is an elevation view diagram illustrating a display assembly according to an embodiment of the present disclosure.", "The use of the same reference symbols in different drawings indicates similar or identical items.", "DETAILED DESCRIPTION OF THE DRAWINGS The following description in combination with the Figures is provided to assist in understanding the teachings disclosed herein.", "The description is focused on specific implementations and embodiments of the teachings, and is provided to assist in describing the teachings.", "This focus should not be interpreted as a limitation on the scope or applicability of the teachings.", "FIG.", "1 illustrates a generalized embodiment of information handling system 100.For purpose of this disclosure information handling system 100 can include any instrumentality or aggregate of instrumentalities operable to compute, classify, process, transmit, receive, retrieve, originate, switch, store, display, manifest, detect, record, reproduce, handle, or utilize any form of information, intelligence, or data for business, scientific, control, entertainment, or other purposes.", "For example, information handling system 100 can be a personal computer, a laptop computer, a smart phone, a tablet device or other consumer electronic device, a network server, a network storage device, a switch router or other network communication device, or any other suitable device and may vary in size, shape, performance, functionality, and price.", "Further, information handling system 100 can include processing resources for executing machine-executable code, such as a central processing unit (CPU), a programmable logic array (PLA), an embedded device such as a System-on-a-Chip (SoC), or other control logic hardware.", "Information handling system 100 can also include one or more computer-readable medium for storing machine-executable code, such as software or data.", "Additional components of information handling system 100 can include one or more storage devices that can store machine-executable code, one or more communications ports for communicating with external devices, and various input and output (I/O) devices, such as a keyboard, a mouse, and a video display.", "Information handling system 100 can also include one or more buses operable to transmit information between the various hardware components.", "Information handling system 100 can include devices or modules that embody one or more of the devices or modules described above, and operates to perform one or more of the methods described above.", "Information handling system 100 includes a processors 102 and 104, a chipset 110, a memory 120, a graphics interface 130, a disk controller 150, a disk emulator 160, an input/output (I/O) interface 170, and a network interface 180.Processor 102 is connected to chipset 110 via processor interface 106, and processor 104 is connected to chipset 110 via processor interface 108.Memory 120 is connected to chipset 110 via a memory bus 122.Graphics interface 130 is connected to chipset 110 via a graphics interface 132, and provides a video display output 136 to a video display 134.In a particular embodiment, information handling system 100 includes separate memories that are dedicated to each of processors 102 and 104 via separate memory interfaces.", "An example of memory 120 includes random access memory (RAM) such as static RAM (SRAM), dynamic RAM (DRAM), non-volatile RAM (NV-RAM), or the like, read only memory (ROM), another type of memory, or a combination thereof.", "Memory 120 can store and provide retrieval of, for example, application software 123 and operating system software 124.Application software 123 can interact with operating system software 124, as illustrated by linkage 127.The operating system software 124 can access, and be accessed by, other system elements via mechanisms other than memory bus 122.For example, operating system interface 126 can enable such access, as illustrated by linkage 125.Operating system interface 126 can communicate with other system elements, such as embedded controller 143 and touch controller 141 via operating system interface bus 142.Embedded controller 143 is connected to chipset 110 via embedded controller bus 144.Embedded controller 143 is connected to a communication bus 146 via connection 145.Embedded controller 143 is connected to touch controller 141 via operating system bus 142.Touch controller 141 is connected to chipset 110 via touch controller bus 147.Touch controller 141 is connected to touch panel 137 via touch panel bus 140.Touch panel 137 is sensitive to touch over a plurality of areas, such as a first primary area 138 and a second primary area 139.Touch panel 137 can be sensitive to touch over additional areas, such as a secondary area.", "Touch panel 137 can be disposed parallel to and physically aligned with video display 134, allowing the touching of objects, such as icons, displayed on video display 134 to be detected and localized.", "Disk controller 150 and I/O interface 170 are connected to chipset 110 via an I/O channel 112.An example of I/O channel 112 includes a Peripheral Component Interconnect (PCI) interface, a PCI-Extended (PCI-X) interface, a high-speed PCI-Express (PCIe) interface, another industry standard or proprietary communication interface, or a combination thereof.", "Chipset 110 can also include one or more other I/O interfaces, including an Industry Standard Architecture (ISA) interface, a Small Computer Serial Interface (SCSI) interface, an Inter-Integrated Circuit (I2C) interface, a System Packet Interface (SPI), a Universal Serial Bus (USB), another interface, or a combination thereof.", "Disk controller 150 includes a disk interface 152 that connects the disc controller to a hard disk drive (HDD) 154, to an optical disk drive (ODD) 156, and to disk emulator 160.An example of disk interface 152 includes an Integrated Drive Electronics (IDE) interface, an Advanced Technology Attachment (ATA) such as a parallel ATA (PATA) interface or a serial ATA (SATA) interface, a SCSI interface, a USB interface, a proprietary interface, or a combination thereof.", "Disk emulator 160 permits a solid-state drive 164 to be connected to information handling system 100 via an external interface 162.An example of external interface 162 includes a USB interface, an IEEE 1194 (Firewire) interface, a proprietary interface, or a combination thereof.", "Alternatively, solid-state drive 164 can be disposed within information handling system 100.I/O interface 170 includes a peripheral interface 172 that connects the I/O interface to an add-on resource 174 and to network interface 180.Peripheral interface 172 can be the same type of interface as I/O channel 112, or can be a different type of interface.", "As such, I/O interface 170 extends the capacity of I/O channel 112 when peripheral interface 172 and the I/O channel are of the same type, and the I/O interface translates information from a format suitable to the I/O channel to a format suitable to the peripheral channel 172 when they are of a different type.", "Add-on resource 174 can include a data storage system, an additional graphics interface, a network interface card (NIC), a sound/video processing card, another add-on resource, or a combination thereof.", "Add-on resource 174 can be on a main circuit board, on separate circuit board or add-in card disposed within information handling system 100, a device that is external to the information handling system, or a combination thereof.", "Network interface 180 represents a NIC disposed within information handling system 100, on a main circuit board of the information handling system, integrated onto another component such as chipset 110, in another suitable location, or a combination thereof.", "Network interface device 180 includes network channels 182 and 184 that provide interfaces to devices that are external to information handling system 100.In a particular embodiment, network channels 182 and 184 are of a different type than peripheral channel 172 and network interface 180 translates information from a format suitable to the peripheral channel to a format suitable to external devices.", "An example of network channels 182 and 184 includes InfiniBand channels, Fibre Channel channels, Gigabit Ethernet channels, proprietary channel architectures, or a combination thereof.", "Network channels 182 and 184 can be connected to external network resources (not illustrated).", "The network resource can include another information handling system, a data storage system, another network, a grid management system, another suitable resource, or a combination thereof.", "FIG.", "2 is a plan view diagram illustrating an information handling system in a flat physical configuration according to an embodiment of the present disclosure.", "Information system 200 includes housing 201 and a display assembly that includes first primary area 203, second primary area 204, and secondary area 202.Secondary area 202 is defined to be a defined bending area, where the display assembly is intended to bend.", "First primary area 203 and second primary area 204 are each defined to be a defined non-bending area, where the display assembly is not intended to bend.", "FIG.", "3 is a perspective view diagram illustrating an information handling system in a flexed physical configuration according to an embodiment of the present disclosure.", "Information handling system 300 includes the housing 201 and the display assembly of FIG.", "2, but housing 201 and the display assembly have been bent at an obtuse angle in the directions depicted by arrows 205 and 206.As illustrated, the bending occurs along secondary area 202, which is a defined bending area, not along first primary area 203 and second primary area 204, which are defined non-bending areas.", "FIG.", "4 is a perspective view diagram illustrating an information handling system in a folded physical configuration according to an embodiment of the present disclosure.", "Information handling system 400 includes the housing 201 and the display assembly of FIGS.", "2 and 3, but housing 201 and the display assembly have been bent at an acute angle with a radius of curvature at the bend, which lies along secondary area 202, which is a defined bending area.", "Second primary area 204, which is a defined non-bending area, remains unbent, as does first primary area 203 (not shown in FIG.", "4, but on an opposite side of information handling system 400 from second primary area 204.Existing technology for a display assembly having a touch panel is incompatible with repetitive flexure.", "Brittle materials, such as glass and indium titanium oxide (ITO) tend to fracture and fail with flexure, especially repetitive flexure.", "Other elements of an existing display assembly are also ill-suited for flexure, and tolerate only slight flexure.", "FIG.", "5 is flow diagram illustrating a method according to an embodiment of the present disclosure.", "Method 500 begins in block 501.From block 501, method 500 continues to block 502.In block 502, a first touch panel indication is detected.", "From block 502, method 500 continues to decision block 503.In decision block 503, a decision is made as to whether the first touch panel indication is from a first touch sensor element within a defined bending area between two defined non-bending areas of a display assembly comprising a touch panel or from a second touch sensor element within one of the two defined non-bending areas.", "If the first touch panel indication is from a second touch sensor element within one of the two defined non-bending areas, method 500 continues to block 504.In block 504, the touch location is determined based directly on the location of the second touch sensor element.", "If the first touch panel indication is from a first touch sensor element within a defined bending area, method 500 continues to decision block 505.In decision block 505, a decision is made as to whether there is a second touch panel indication from a third touch sensor element adjacent to the first touch sensor element.", "If not, method 500 continues to block 506.In block 506, the touch location is determined based directly on the location of the first touch sensor element.", "If there is a second touch panel indication from a third touch sensor element adjacent to the first touch sensor element, method 500 continues to decision block 507.In decision block 507, a decision is made as to whether the first touch panel indication and the second touch panel indication occurred simultaneously or sequentially.", "If the first touch panel indication and the second touch panel indication occurred simultaneously, method 500 continues to block 508.In block 508, the touch location is determined by interpolating between the location of the first touch sensor element and the location of the third touch sensor element.", "If the first touch panel indication and the second touch panel indication occurred sequentially, method 500 continues to block 509.In block 509, the touch location is determined by extrapolating beyond the location of the latter of the first touch panel indication and the second touch panel indication.", "For example, if the second touch panel indication occurs after the first touch panel indication occurs, the touch location is determined to be on a side of the location indicated by the second touch panel location opposite the location indicated by the first touch panel indication.", "FIG.", "6 is flow diagram illustrating a method according to an embodiment of the present disclosure.", "Method 600 begins in block 601.From block 601, method 600 continues to block 602.In block 602, sensor outputs are received.", "As an example, in block 603, strain and acceleration sensors are monitored.", "As another example, in block 604, orientation and gyroscopic sensors are monitored.", "From block 602, method 600 can continue to block 605.In block 605, a primary area of the display assembly is activated.", "The primary area can be determined in response to the sensor outputs of block 602.From block 605, method 600 continues to block 606.In block 606, a physical configuration of the information handling system is determined.", "The sensor outputs of block 602 can be used to determine the physical configuration of the information handling system.", "From block 606, method 600 continues to decision block 607.In decision block 607, a decision is made as to whether the information handling system is folded or flat.", "If the information handling system is determined to be folded, method 600 continues to block 610.In block 610, the secondary area is deactivated.", "Deactivating the secondary area can prevent spurious inputs from being received from the secondary area when the information handling system is folded.", "From block 610, method 600 continues to block 611, where method 600 ends.", "If, in decision block 607, the information handling system is determined to be flat (e.g., not folded), method 600 continues to block 608.In block 608, the secondary area is activated.", "From block 608, method 600 continues to block 609.In block 609, the sensitivity of the secondary area in increased.", "As an example, the sensitivity of the secondary area can be increased to compensate for a reduced sensor matrix density within the secondary area relative to the primary area.", "As an example, the sensitivity of the secondary area can be increased by interpolating between touch panel sensor elements of a portion of the secondary area.", "As another example, the sensitivity of the secondary area can be increased by extrapolating beyond touch panel sensor elements of a portion of the secondary area.", "From block 609, method 600 continues to block 611, where method 600 ends.", "FIG.", "7 is flow diagram illustrating a method of manufacture of a display assembly according to an embodiment of the present disclosure.", "Method 700 begins in block 702.From block 702, method 700 continues to block 704.In block 704, an organic light emitting diode (OLED) video display is assembled into a display assembly.", "From block 704, method 700 continues to block 706.In block 706, a touch panel sensor mask having varied touch panel sensor density, with lower density in a defined bending area than in a defined non-bending area, is introduced into the display assembly.", "From block 706, method 700 continues to block 708.In block 708, silver (Ag) nanowires are printed onto a surface within the display assembly, for example, a front surface of the OLED video display or, as another example, a rear surface of a surface film, wherein a front surface of the surface film provides an exposed front surface of the display assembly.", "From block 708, method 700 continues to block 710.In block 710, a low refractive index microgel is laminated into the display assembly.", "As an example, the low refractive index microgel can be laminated between the OLED video display and the sensor mask.", "As another example, the low refractive index microgel can be laminated between the OLED video display and the silver nanowires.", "As yet another example, the low refractive index microgel can be laminated between the sensor mask and a surface film.", "As a further example, the low refractive index microgel can be laminated between the silver nanowires and the surface film.", "From block 710, method 700 continues to block 712.In block 712, a surface film is cut and formed to provide a cover surface using, for example, thermoplastic elastomer (TPE) or polyethylene terephthalate (PET).", "From block 712, the method continues to block 714.In block 714, microfeatures are thermostamped into the surface film within a defined bending area.", "The microfeatures can be aligned with an expected bend location within the defined bending area.", "For example, the microfeatures can include embossed lines disposed along the expected bend location.", "From block 714, method 700 continues to block 716.In block 716, the exposed front surface of the surface film is silica functionalized to provide surface hardness, for example, by depositing a layer of microscopic silica particles on the exposed front surface.", "From block 716, method 700 continues to block 718.In block 718, the surface film, for example, a hard surface film, is laminated to the display assembly using a thermoplastic elastomer (TPE) adhesive.", "FIG.", "8 is an elevation view diagram illustrating a display assembly according to an embodiment of the present disclosure.", "Display assembly 800 includes a flexible substrate 801.For example, flexible substrate 801 can include an aramid material, a unidirectional (UD) carbon fiber material, a graphene material, a thermoplastic elastomer, polyethylene terephthalate (PET), or several of the foregoing materials.", "Thermoplastic elastomers for implementing flexible substrate 801 can include, as an example, a polyamide or polyimide film with high elasticity.", "One example of such a polyimide film, for example, is Langley Research Center Colorless Polyimide 2 (LaRC-CP2) film.", "Other examples of suitable thermoplastic elastomers include copolyesters, polyurethanes, polyamides, polyimides, and thermoplastic elastomer blends & alloys (for example, thermoplastic polyolefins and thermoplastic vulcanizates).", "In accordance with at least one embodiment, layered aramid having a thickness of greater than 0.2 mm and thermoplastic vulcanizates are used to produce a composite flexible substrate having a thickness of up to 0.8 mm.", "Display assembly 800 includes an OLED video display 802 located above and parallel to flexible substrate 801.Display assembly 800 includes a touch panel 804 located above and parallel to OLED video display 802.Display assembly 800 can include a microgel layer 803 between OLED video display 802 and touch panel 804.Display assembly 800 includes a surface film 806.Examples of suitable materials for surface film 806 include colorless TPE films, which can include the examples described above with respect to flexible substrate 801, and polyethylene terephthalate (PET).", "Display assembly 800 can include a microgel layer 805 between touch panel 804 and surface film 806.As an example, the microgel layers 803 and 805 can be made from ALPHA GEL available from Taica Corporation, Takanawa Sengakuji-ekimae Bldg.", "3F, 2-18-10 Takanawa, Minato-ku, Tokyo 108-0074, Japan.", "Surface film 806 includes microfeatures 807 formed on an exposed surface of surface film 806.Microfeatures 807 are formed within a defined bending area 809 of display assembly 800 but not within defined non-bending areas 808 and 810 of display assembly 800.Microfeatures 807 can have thin valleys and ridges, as shown in FIG.", "8, or other suitable shapes, such as thin cuts between flat strips, as will reduce the stress of bending on surface film 806.In accordance with at least one embodiment, nanowires are screen printed to form a bendable touch sensor array.", "This touch sensor array is printed on film and laminated on a display using low durometer polymer, such a silicone dydrogel, so that the display assembly can accommodate bending.", "For example, 10,000 to 20,000 cycles of bending with a 1 cm bend radius can be accommodated.", "Even if some wear occurs at the bending point, such wear can be accommodated by wear tolerant features.", "One wear tolerant feature involves changing the touch sensor element density at the bending point to reduce stress and increasing the touch sensor element sensitivity to maintain touch panel functionality and resolution.", "Another wear tolerant feature involves using a three segment sensor, leaving the bending point sensor free.", "Based on a direction of swipe and application, software in an embedded controller can provide seamless interaction by interpolating or extrapolating a touch position from available information even over a sensor free region.", "In accordance with at least one embodiment, materials assembly and touch sensor control by a controller allow touch panel utilization over a flat region even as another region of the touch panel may or may not be flat.", "For example, display assembly including a touch panel uses nanowire based sensor elements with varied sensor element density, including lower density at the folding point or in other areas where the tension and compression are the highest.", "A low refractive index microgel, such as a silicone dydrogel, is used at an interface between display assembly elements to tolerate bending.", "The top cover, such as a surface film, is stamped, for example, using thermostamping, which involves sufficient heat to cause the top cover to flow under the pressure of stamping, at a micron level so that compression of bending is dissipated.", "An example of suitable nanowire material is CLEAROHM silver nanowire coating from Cambrios Technologies Corporation, 930 East Argues Ave., Sunnyvale, Calif. 94085.In accordance with at least one embodiment, brittle materials, such as ITO and other brittle oxide materials are avoided and not included in the display assembly.", "The touch sensitivity at a specific location, such as within a defined bending region, is managed based on orientation and which portion of the display assembly is active for a given device configuration.", "In accordance with at least one embodiment, the touch panel does not include a continuous transparent oxide layer.", "As an example, the touch panel does not include a transparent oxide layer continuously coextensive with an entire region occupied by the touch panel.", "In accordance with at least one embodiment, the touch panel includes a plurality (for example, two or three) of segments of transparent oxide layer for touch functionality while allowing bending to occur between the segments.", "As an example, the touch panel includes a discontinuous plurality of transparent oxide layers arranged in a coplanar configuration when the touch panel is in a flat mode.", "Joints between the discontinuous regions of the layers are oriented linearly to form lines along which bending can occur without subjecting the transparent oxide layers to excessive stress.", "As an example, one or more transparent oxide layers can be limited in extent to not exceed an entire defined non-bending area.", "Each defined non-bending area may be provided with its own one or more transparent oxide layers such that no transparent oxide layer of a defined non-bending area crosses a defined bending area.", "In accordance with at least one embodiment, one or more transparent oxide layers separate from any transparent oxide layer of a defined non-bending area may be disposed in a defined bending area, provided any such one or more transparent oxide layer is of a size and shape compatible with the defined bending area.", "For example, one or more transparent oxide layers disposed in a defined bending area may be thinner and of a smaller area than a transparent oxide layer disposed in a defined non-bending area.", "In one example embodiment, the touch sensor elements in the defined bending area are spaced with greater separation so that stress is low even when the display assembly is bent.", "In this case, the cover plastic, such as a surface film, can be saw-tooth grooved or of a reduced thickness within at least a portion of the defined bending area, for example, by micro-stamping features so that bending stress is minimal on the surface and on the sensors.", "In another example embodiment, the touch sensor element array is separated and discontinuous at the highest curvature point and touch continuity is managed by a controller based on information received from touch sensor elements on one or both sides of the gap between touch sensor elements within the defined bending area.", "Given a swipe direction, as identified by a controller, the touch function is extrapolated beyond existent touch sensor elements to provide touch location determination even in a region devoid of touch sensor elements.", "It is also possible to increase sensor sensitivity at the controller, thereby providing a proximity mode for scroll or swipe operations.", "In an alternative embodiment, dedicated hardware implementations such as application specific integrated circuits, programmable logic arrays and other hardware devices can be constructed to implement one or more of the methods described herein.", "Applications that may include the apparatus and systems of various embodiments can broadly include a variety of electronic and computer systems.", "One or more embodiments described herein may implement functions using two or more specific interconnected hardware modules or devices with related control and data signals that can be communicated between and through the modules, or as portions of an application-specific integrated circuit.", "Accordingly, the present system encompasses software, firmware, and hardware implementations.", "In accordance with various embodiments of the present disclosure, the methods described herein may be implemented by software programs executable by a computer system.", "Further, in an exemplary, non-limited embodiment, implementations can include distributed processing, component/object distributed processing, and parallel processing.", "Alternatively, virtual computer system processing can be constructed to implement one or more of the methods or functionality as described herein.", "While the computer-readable medium is shown to be a single medium, the term “computer-readable medium” includes a single medium or multiple media, such as a centralized or distributed database, and/or associated caches and servers that store one or more sets of instructions.", "The term “computer-readable medium” shall also include any medium that is capable of storing, encoding, or carrying a set of instructions for execution by a processor or that cause a computer system to perform any one or more of the methods or operations disclosed herein.", "In a particular non-limiting, exemplary embodiment, the computer-readable medium can include a solid-state memory such as a memory card or other package that houses one or more non-volatile read-only memories.", "Further, the computer-readable medium can be a random access memory or other volatile re-writable memory.", "Additionally, the computer-readable medium can include a magneto-optical or optical medium, such as a disk or tapes or other storage device to store information received via carrier wave signals such as a signal communicated over a transmission medium.", "Furthermore, a computer readable medium can store information received from distributed network resources such as from a cloud-based environment.", "A digital file attachment to an e-mail or other self-contained information archive or set of archives may be considered a distribution medium that is equivalent to a tangible storage medium.", "Accordingly, the disclosure is considered to include any one or more of a computer-readable medium or a distribution medium and other equivalents and successor media, in which data or instructions may be stored.", "In the embodiments described herein, an information handling system includes any instrumentality or aggregate of instrumentalities operable to compute, classify, process, transmit, receive, retrieve, originate, switch, store, display, manifest, detect, record, reproduce, handle, or use any form of information, intelligence, or data for business, scientific, control, entertainment, or other purposes.", "For example, an information handling system can be a personal computer, a consumer electronic device, a network server or storage device, a switch router, wireless router, or other network communication device, a network connected device (cellular telephone, tablet device, etc.", "), or any other suitable device, and can vary in size, shape, performance, price, and functionality.", "The information handling system can include memory (volatile (e.g.", "random-access memory, etc.", "), nonvolatile (read-only memory, flash memory etc.)", "or any combination thereof), one or more processing resources, such as a central processing unit (CPU), a graphics processing unit (GPU), hardware or software control logic, or any combination thereof.", "Additional components of the information handling system can include one or more storage devices, one or more communications ports for communicating with external devices, as well as, various input and output (I/O) devices, such as a keyboard, a mouse, a video/graphic display, or any combination thereof.", "The information handling system can also include one or more buses operable to transmit communications between the various hardware components.", "Portions of an information handling system may themselves be considered information handling systems.", "When referred to as a “device,” a “module,” or the like, the embodiments described herein can be configured as hardware.", "For example, a portion of an information handling system device may be hardware such as, for example, an integrated circuit (such as an Application Specific Integrated Circuit (ASIC), a Field Programmable Gate Array (FPGA), a structured ASIC, or a device embedded on a larger chip), a card (such as a Peripheral Component Interface (PCI) card, a PCI-express card, a Personal Computer Memory Card International Association (PCMCIA) card, or other such expansion card), or a system (such as a motherboard, a system-on-a-chip (SoC), or a stand-alone device).", "Devices, modules, resources, or programs that are in communication with one another need not be in continuous communication with each other, unless expressly specified otherwise.", "In addition, devices, modules, resources, or programs that are in communication with one another can communicate directly or indirectly through one or more intermediaries.", "Although only a few exemplary embodiments have been described in detail herein, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of the embodiments of the present disclosure.", "Accordingly, all such modifications are intended to be included within the scope of the embodiments of the present disclosure as defined in the following claims.", "In the claims, means-plus-function clauses are intended to cover the structures described herein as performing the recited function and not only structural equivalents, but also equivalent structures." ] ]
Patent_15874368
[ [ "COMMUNICATIONS DEVICE AND METHODS", "A communications device establishes a communications context for communicating data packets using a packet communications bearer from the communications device via the mobile communications network.", "A controller of the communications device is configured to identify that the communications device can enter a stasis state because no data packets are available for transmission for a predetermined time via the packet communications bearer or there are no data packets to receive via the packet communications bearer, to transmit a stasis state message to the mobile communications network, and to store information relating to the communications context associated with the packet communications bearer in a data store.", "The stored information can be used by the controller to re-establish the packet communications bearer to transmit and/or receive data packets using the packet communications bearer, the communications device thereby entering the stasis state." ], [ "1.A communications device for transmitting data to and receiving data from a mobile communications network, the mobile communications network including one or more network elements providing a wireless access interface for communicating with the communications device, the communications device comprising: circuitry configured to transmit signals to the mobile communications network via the wireless access interface provided by the one or more network elements of the mobile communications network, receive signals from the mobile communications network via the wireless access interface provided by the one or more network elements of the mobile communications network, control transmission of one or more signalling messages to the communications network, control reception of one or more signalling messages from the communications network to establish a communications context for communicating data packets using a packet communications bearer from the communications device via the mobile communications network, identify that the communications device can enter a stasis state because no data packets are available for transmission for a predetermined time via the packet communications bearer or there are no data packets to receive via the packet communications bearer, transmit a stasis state message to the mobile communications network, and store information relating to the communications context associated with the packet communications bearer in a memory, the stored information being used by the circuitry to re-establish the packet communications bearer to at least one of transmit or receive data packets using the packet communications bearer, to place the communication device entering the stasis state.", "2.The communications device according to claim 1, wherein the circuitry is further configured to, upon detecting that the communications device can enter the stasis state, store a network terminal identifier with the information relating to the communications context, the network terminal identifier being provided to the communications device by the mobile communications network for requesting communications resources when the communications context was established, and upon detecting that the communications device should exit from the stasis state and enter a connected state, the circuitry is configured to transmit a request to re-connect message to the mobile communications network, the request to connect message including the network terminal identifier, which is recognised by the mobile communications network to re-establish the packet communications bearer.", "3.The communications device according to claim 1, wherein the circuitry is configured to store in the memory one or more sequence numbers associated with one or more protocols of a protocol stack which forms the packet communications bearer when entering the stasis state to allow the stored sequence numbers to be restored to the one or more protocols of the protocol stack to transmit or receive signals via the wireless access interface, when the communications device moves from the stasis state to the connected state.", "4.The communications device according to claim 3, wherein the information relating to the context which is stored by the circuitry in the memory includes one or more of a sequence number associated with a radio link control protocol, a packet data communications protocol or a configuration of a medium access control layer.", "5.The communications device according to claim 3, wherein the information relating to the context which is stored by the circuitry in the memory includes a sequence number and a cyphering key associated with a sequence context.", "6.The communications device according to claim 1, wherein the circuitry is configured to monitor signals received via the wireless access interface to perform measurements and in accordance with predetermined conditions based on the measurements, the circuitry being configured to re-establish the same packet communications bearer.", "7.The communications device according to claim 6, wherein the measurements performed by the circuitry determine whether the communications device should handover from a base station to which the communications device is attached to another base station to at least one of transmit or receive data packets via the same packet communications bearer, the communications device thereby entering the connected state from the stasis state.", "8.A method of transmitting data to and receiving data from a mobile communications network from a communications device, the mobile communications network including one or more network elements providing a wireless access interface for communicating with the communications device, the method comprising: transmitting, with circuitry, one or more signalling messages to the mobile communications network; receiving, with the circuitry, one or more signalling messages from the communications network to establish a communications context for communicating data packets using a packet communications bearer from the communications device via the mobile communications network; identifying, with the circuitry, that the communications device can enter a stasis state because no data packets are available for transmission for a predetermined time via the packet communications bearer or there are no data packets to receive via the packet communications bearer; transmitting, with the circuitry, a stasis state message to the mobile communications network; and storing, with the circuitry, information relating to the communications context associated with the packet communications bearer in a memory, which stored information can be used by the controller using the transmitter unit and the receiver unit to re-establish the packet communications bearer to at least one of transmit or receive data packets using the packet communications bearer, the communications device thereby entering the stasis state.", "9.The method as according to claim 8, wherein the storing of the information relating to the communications context associated with the packet communications bearer in the memory, comprises: storing, by the circuitry and with the information relating to the communications context, a network terminal identifier provided to the communications device by the mobile communications network for requesting communications resources when the communications context was established; and upon detecting that the communications device should exit from the stasis state and enter a connected state, transmitting, by the circuitry, a request to re-connect message to the mobile communications network, the request to connect message including the network terminal identifier, which is recognised by the mobile communications network to re-establish the packet communications bearer.", "10.The method according to claim 8, wherein the storing of information relating to the communications context associated with the packet communications bearer in the memory, comprises: storing, by the circuitry and in the memory, one or more sequence numbers associated with one or more protocols of a protocol stack which forms the packet communications bearer when entering the stasis state to the effect that, when the communications device moves from the stasis state to the connected state the stored sequence numbers can be restored to the one or more protocols of the protocol stack to transmit or receive signals via the wireless access interface." ], [ "<SOH> BACKGROUND OF THE DISCLOSURE <EOH>Mobile communications systems continue to be developed to provide wireless communications services to a greater variety of electronic devices.", "In more recent years, third and fourth generation mobile telecommunication systems, such as those based on the 3GPP defined UMTS and Long Term Evolution (LTE) architectures have been developed to support more sophisticated communications services to personal computing and communications devices than simple voice and messaging services offered by previous generations of mobile telecommunication systems.", "For example, with the improved radio interface and enhanced data rates provided by LTE systems, a user may enjoy high data rate applications such as mobile video streaming and mobile video conferencing that would previously only have been available via a fixed line data connection.", "The demand to deploy third and fourth generation networks is therefore strong and the coverage area of these networks, i.e.", "geographic locations where access to the networks is possible, is expected to increase rapidly.", "More recently it has been recognised that rather than providing high data rate communications services to certain types of electronics devices, it is also desirable to provide communications services to electronics devices that are simpler and less sophisticated.", "For example, so-called machine type communication (MTC) applications may be semi-autonomous or autonomous wireless communication devices which may communicate small amounts of data on a relatively infrequent basis.", "Some examples include so-called smart meters which, for example, are located in a customer's house and periodically transmit information back to a central MTC server data relating to the customer's consumption of a utility such as gas, water, electricity and so on.", "Whilst it can be convenient for a communications device such as an MTC type device to take advantage of the wide coverage area provided by a third or fourth generation mobile telecommunication network there are at present disadvantages.", "Unlike a conventional third or fourth generation communications device such as a smartphone, a lower complexity device may operate with a lower bandwidth and be preferably relatively simple and inexpensive.", "The type of functions performed by the MTC-type device (e.g.", "collecting and reporting back data) do not require particularly complex processing to perform.", "As will be appreciated, there may be a desire for many types of communications devices and mobile communications networks to use communications resources as efficiently as possible and to reduce power consumption.", "It is known for example to reduce the power consumed by a communications device by performing what is known as discontinuous reception.", "Discontinuous reception is a technique in which a communications device may be radio resource connected, but after monitoring a control channel to determine whether communications resources have been allocated to the communications device, the communications device can sleep for a remainder of a time before another transmission may occur on the control channel A communications device may also be configured with a short and a long discontinuous reception timer.", "If no activity is detected for a short discontinuous reception time, then the communications device moves to a long discontinuous reception timer.", "Accordingly the communications device can save power." ], [ "<SOH> SUMMARY OF THE DISCLOSURE <EOH>Embodiments of the present disclosure can provide in one example a communication device for transmitting data to and receiving data from a mobile communications network.", "The mobile communications network includes one or more network elements providing a wireless access interface for communicating with the communications device.", "The communications device comprising a transmitter unit configured to transmit signals to the mobile communications network via the wireless access interface provided by the one or more network elements of the mobile communications network, and a receiver unit configured to receive signals from the mobile communications network via the wireless access interface provided by the one or more network elements of the mobile communications network, and a controller.", "The controller is configured to control the transmitter unit to transmit one or more signalling messages to the communications network and the receiver unit to receive one or more signalling messages from the communications network to establish a communications context for communicating data packets using a packet communications bearer from the communications device via the mobile communications network.", "The controller is configured to identify that the communications device can enter a stasis state because no data packets are available for transmission for a predetermined time via the packet communications bearer or there are no data packets to receive via the packet communications bearer, to transmit a stasis state message to the mobile communications network, and to store information relating to the communications context associated with the packet communications bearer in a data store.", "The stored information can be used by the controller using the transmitter unit and the receiver unit to re-establish the packet communications bearer to transmit and/or receive data packets using the packet communications bearer, the communications device thereby entering the stasis state.", "Embodiments of the present technique can provide can arrangement in which a communications device can enter a stasis state in which a current state of protocols associated with a communications bearer for both the wireless access interface and via a mobile communications network are saved.", "However radio resources associated with the communications context and therefore the communications bearer are released for allocation to other communications devices.", "If the mobile communications device then needs to transmit or receive data for example if there are data packets to be transmitted via the mobile communications network, then the communications device can transmit a request message to transit from the stasis state to the connected state, re-establishing the communications bearer by recovering from the data store the state of the protocols of the communications bearer as defined by the communication contexts as they were saved before the stasis state.", "Accordingly there is a saving in both communications resources and power because the previous communications context and communications bearer has been saved and therefore does not need to be established.", "In contrast conventional techniques would require that the radio resources and the communications bearer are released by the mobile communications network so that the communications device would have to re-create a communications context by performing a routine which requires an exchange of messages with the mobile communications network.", "Accordingly there is a saving in both communications resources and power consumed by the communications device.", "In a radio resource idle state, a communications device is conventionally arranged to respond to a paging message transmitted by the communications network.", "The occasions when it may be paged, are indicated by System Information and these must coincide with the OnDurationTime of RRC_CONNECTED discontinuous reception so that the communications monitors control channels such as the PDCCHs in order to detect a paging identifies such as a P-RNTI.", "As such, in some examples the communications device may be configured to move out from the stasis state into the connected state in order to receive downlink data packets after receiving a paging message.", "Further aspects and features of the present disclosure are defined in the appended claims, including but not limited to, a mobile communications device, a method of communicating, a network infrastructure element, a communications network and the method of communicating via a wireless access interface." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS The present application is a continuation of U.S. application Ser.", "No.", "14/784,656 filed on Oct. 15, 2015, which is a National Phase of PCT/GB2014/050972 filed on Mar.", "27, 2014, and claims priority to British Patent Application 1307186.5, filed in the UK IPO on Apr.", "22, 2013, the entire contents of each of which are incorporated herein by reference.", "TECHNICAL FIELD OF THE DISCLOSURE The present disclosure relates to communications devices, and methods of communicating using communications devices, infrastructure equipment for mobile communications networks, mobile communications networks and systems and methods of communicating using mobile communications networks.", "BACKGROUND OF THE DISCLOSURE Mobile communications systems continue to be developed to provide wireless communications services to a greater variety of electronic devices.", "In more recent years, third and fourth generation mobile telecommunication systems, such as those based on the 3GPP defined UMTS and Long Term Evolution (LTE) architectures have been developed to support more sophisticated communications services to personal computing and communications devices than simple voice and messaging services offered by previous generations of mobile telecommunication systems.", "For example, with the improved radio interface and enhanced data rates provided by LTE systems, a user may enjoy high data rate applications such as mobile video streaming and mobile video conferencing that would previously only have been available via a fixed line data connection.", "The demand to deploy third and fourth generation networks is therefore strong and the coverage area of these networks, i.e.", "geographic locations where access to the networks is possible, is expected to increase rapidly.", "More recently it has been recognised that rather than providing high data rate communications services to certain types of electronics devices, it is also desirable to provide communications services to electronics devices that are simpler and less sophisticated.", "For example, so-called machine type communication (MTC) applications may be semi-autonomous or autonomous wireless communication devices which may communicate small amounts of data on a relatively infrequent basis.", "Some examples include so-called smart meters which, for example, are located in a customer's house and periodically transmit information back to a central MTC server data relating to the customer's consumption of a utility such as gas, water, electricity and so on.", "Whilst it can be convenient for a communications device such as an MTC type device to take advantage of the wide coverage area provided by a third or fourth generation mobile telecommunication network there are at present disadvantages.", "Unlike a conventional third or fourth generation communications device such as a smartphone, a lower complexity device may operate with a lower bandwidth and be preferably relatively simple and inexpensive.", "The type of functions performed by the MTC-type device (e.g.", "collecting and reporting back data) do not require particularly complex processing to perform.", "As will be appreciated, there may be a desire for many types of communications devices and mobile communications networks to use communications resources as efficiently as possible and to reduce power consumption.", "It is known for example to reduce the power consumed by a communications device by performing what is known as discontinuous reception.", "Discontinuous reception is a technique in which a communications device may be radio resource connected, but after monitoring a control channel to determine whether communications resources have been allocated to the communications device, the communications device can sleep for a remainder of a time before another transmission may occur on the control channel A communications device may also be configured with a short and a long discontinuous reception timer.", "If no activity is detected for a short discontinuous reception time, then the communications device moves to a long discontinuous reception timer.", "Accordingly the communications device can save power.", "SUMMARY OF THE DISCLOSURE Embodiments of the present disclosure can provide in one example a communication device for transmitting data to and receiving data from a mobile communications network.", "The mobile communications network includes one or more network elements providing a wireless access interface for communicating with the communications device.", "The communications device comprising a transmitter unit configured to transmit signals to the mobile communications network via the wireless access interface provided by the one or more network elements of the mobile communications network, and a receiver unit configured to receive signals from the mobile communications network via the wireless access interface provided by the one or more network elements of the mobile communications network, and a controller.", "The controller is configured to control the transmitter unit to transmit one or more signalling messages to the communications network and the receiver unit to receive one or more signalling messages from the communications network to establish a communications context for communicating data packets using a packet communications bearer from the communications device via the mobile communications network.", "The controller is configured to identify that the communications device can enter a stasis state because no data packets are available for transmission for a predetermined time via the packet communications bearer or there are no data packets to receive via the packet communications bearer, to transmit a stasis state message to the mobile communications network, and to store information relating to the communications context associated with the packet communications bearer in a data store.", "The stored information can be used by the controller using the transmitter unit and the receiver unit to re-establish the packet communications bearer to transmit and/or receive data packets using the packet communications bearer, the communications device thereby entering the stasis state.", "Embodiments of the present technique can provide can arrangement in which a communications device can enter a stasis state in which a current state of protocols associated with a communications bearer for both the wireless access interface and via a mobile communications network are saved.", "However radio resources associated with the communications context and therefore the communications bearer are released for allocation to other communications devices.", "If the mobile communications device then needs to transmit or receive data for example if there are data packets to be transmitted via the mobile communications network, then the communications device can transmit a request message to transit from the stasis state to the connected state, re-establishing the communications bearer by recovering from the data store the state of the protocols of the communications bearer as defined by the communication contexts as they were saved before the stasis state.", "Accordingly there is a saving in both communications resources and power because the previous communications context and communications bearer has been saved and therefore does not need to be established.", "In contrast conventional techniques would require that the radio resources and the communications bearer are released by the mobile communications network so that the communications device would have to re-create a communications context by performing a routine which requires an exchange of messages with the mobile communications network.", "Accordingly there is a saving in both communications resources and power consumed by the communications device.", "In a radio resource idle state, a communications device is conventionally arranged to respond to a paging message transmitted by the communications network.", "The occasions when it may be paged, are indicated by System Information and these must coincide with the OnDurationTime of RRC_CONNECTED discontinuous reception so that the communications monitors control channels such as the PDCCHs in order to detect a paging identifies such as a P-RNTI.", "As such, in some examples the communications device may be configured to move out from the stasis state into the connected state in order to receive downlink data packets after receiving a paging message.", "Further aspects and features of the present disclosure are defined in the appended claims, including but not limited to, a mobile communications device, a method of communicating, a network infrastructure element, a communications network and the method of communicating via a wireless access interface.", "BRIEF DESCRIPTION OF DRAWINGS Embodiments of the present disclosure will now be described by way of example only with reference to the accompanying drawings in which like parts are provided with corresponding reference numerals and in which: FIG.", "1 provides a schematic diagram illustrating an example of a mobile communications network configured in accordance with LTE; FIG.", "2 provides a schematic diagram illustrating an arrangement of an Enhanced Packet Service bearer established for communicating data packets via the mobile communications network; FIG.", "3 provides a schematic diagram representing the states of the communications device including whether the device is EMM registered or ECM connected; FIG.", "4 is a schematic illustration of state transitions of a communications device operating in the mobile communications network of FIG.", "1; FIG.", "5 is a simplified call flow diagram illustrating a process in which a communications device establishes and an EPS bearer for communicating data via the mobile communications network shown in FIG.", "1; FIG.", "6 is a schematic block diagram illustrating functions performed by infrastructure equipment of the mobile indications network shown in FIG.", "1 to provide an EPS bearer; FIG.", "7 is a schematic block diagram illustrating the protocol stack for a control plane of infrastructure equipment forming part of the mobile communications network shown in FIG.", "1; FIG.", "8 is a schematic block diagram illustrating the protocol stack for user plane of a communications device (UE) and is a base station (eNB); FIG.", "9a is a call flow diagram illustrating an exchange of signalling messages between a communications device and infrastructure equipment of the mobile communications network shown in FIG.", "1 to establish a communications context; and FIG.", "9b is a corresponding call flow diagram illustrating an exchange of messages to release communications resources; FIG.", "10 is a schematic illustration of a state diagram of a communications device operating in accordance with the present technique which includes a new stasis state; FIG.", "11 is a schematic illustration of state transition diagram of a communications device which transitions to a stasis state in accordance with the present technique; FIG.", "12 is a call flow diagram illustrating an exchange of messages which includes the operation of a communications device which enters a stasis state in accordance with the present technique; and FIG.", "13 provides a schematic block diagram of a communications device and a base station configured in accordance with an example of the present disclosure.", "DESCRIPTION OF EXAMPLE EMBODIMENTS The example embodiments will be generally described in the context of a 3GPP LTE architecture.", "However, the invention is not limited to an implementation in a 3GPP LTE architecture.", "Conversely, any suitable mobile architecture is considered to be relevant.", "Conventional Network FIG.", "1 provides a schematic diagram illustrating the basic functionality of a conventional mobile telecommunications network.", "The network includes one or more base stations 102 (one base station represented) connected to a serving gateway (S-GW) 103 for traffic in the user plane and to a Mobility Management Entity (MME) for signalling in the control plane.", "In LTE, the base stations are called e-NodeB, which are referred to in the following description as eNB.", "Each base station provides a coverage area 103 within which data can be communicated to and from communications devices 101.Data is transmitted from a base station 102 to a communications device 101 within a coverage area via a radio downlink.", "Data is transmitted from a communications device 101 to a base station 102 via a radio uplink.", "The core network, comprising the MME 105, the S-GW 103 and the PDN-Gateway (P-GW) 104, routes data to and from the communications devices 101 and provides functions such as authentication, mobility management, charging and so on.", "The P-GW is connected to one or more other networks, which may for example include the internet, an IMS core network, etc.", "In the illustration of FIG.", "1, connections on the user plane have been represented with a plain line while connections on the control plane have been represented with a dashed line.", "The term communications devices will be used to refer to a communications terminal or apparatus which can transmit or receive data via the mobile communications system.", "Other terms may also be used for communications devices such as personal computing apparatus, remote terminal, transceiver device or user equipment (UE) which may or may not be mobile.", "FIG.", "2 illustrates an example of a path followed by a message 130 communicated by a communications device 101.In that example an MTC communications device 101, wishes to send the message 130 to a destination 120, the destination being reachable via the internet.", "In this example, a destination device is represented as a computer.", "However the destination 120 could be an element of any suitable type where the element can be addressed by the communications device 101.For example, the destination device 120 may be another communications device, a personal computer, a server, a proxy, or an intermediary element (to a final destination).", "The following description provides a summary explanation of an example of operation in which a communications device communicates the message 130 via an LTE network, which is helpful in appreciating some aspects and advantages of the present technique.", "In order for the communications device 101 to send data to a destination, an EPS bearer between the communications device 101 and the PGW 104 is set up, the EPS bearer being partially carried over a GTP tunnel between the eNB 102 and the SGW and another GTP tunnel between SGW and PGW 104, as illustrated in FIG.", "2.As the message 130 is carried to the destination device, it is sent from the communications device 101, at a first end of an EPS bearer to the eNB 102 (step 1), then to the S-GW 103 (step 2) and then to the P-GW 104 (step 3), at the other end of the EPS bearer.", "The P-GW 104 then forwards the message 130 to the destination 120 (step 4).", "FIG.", "3 illustrates the various transitions between the four possible combinations of ECM states (connected or idle) and EMM states (registered or unregistered) as defined in the LTE standards for a communications device with a view to illustrating how communications devices' connections are managed.", "The acronym ECM stands for “EPS Connection Management” and the ECM state generally indicates whether the communications device has a Non-Access Stratum (NAS) connection set up with the MME.", "In LTE, as the communications device connects to the MME and switches to ECM_connected, it also sets up an EPS bearer, that is, a data connection to the P-GW via the S-GW.", "Also, as the communications device switches from ECM_connected to ECM_idle, the EPS bearer is torn down, and all S1 and RRC connections are released.", "The acronym EMM stands for “EPS Mobility Management” and the EMM state generally indicates whether a communications device is attached to the network.", "When the communications device is in EMM_unregistered, it may for example be turned off, out of coverage or connected to a different network.", "In contrast, when a communications device is in EMM_registered, it is attached to the network and, as such, it has an IP address and a NAS security context in the MME.", "It may or may not have an EPS bearer set up, but in any case, it has some context associated with it in the MME (e.g.", "NAS security context) and in the P-GW (e.g.", "the IP address).", "In addition the MME will know in which tracking areas the UE is located.", "The four ECM/EMM states and the transitions between them is described next.", "The communications device 101 is assumed to start from a state 153 in which the communications device 101 is not connected to the network.", "In the state 153, the communications device is in EMM_unregistered and ECM_idle states.", "From this state, the communications device can attach to the network to be in EMM_registered and ECM_connected states.", "However, in order to attach, the communications device cannot switch to EMM_registered if it has not switched to ECM_connected first.", "In other words, starting from state 153, the communications device cannot go to states 152 or 151 and it has to go to state 154 first.", "Therefore, as illustrated by arrow 161, a communications device in state 153 can attach to the network by first switching to ECM connected and then to EMM_registered.", "As a communications device starts an attachment procedure from state 153, the communications device moves from a state 153 where it does not have any connection to a state 151 where it has a NAS connection to the MME, an IP address allocated by the P-GW, and a EPS bearer to the P-GW via the e-NB and the S-GW.", "Transitions between states 151 and 152 occur when a data connection (EPS bearer) is set up (164) or when all data connections have been released (165).", "Generally, transition 165 occurs when the user had an EPS bearer active and has not been using the bearer for a certain time.", "The network can then decide that the communications device no longer needs an EPS bearer and thus release all the corresponding resources and switch the communications device to ECM_idle.", "Transition 164 generally occurs when the communications device has not been using any EPS bearer (see for example the discussion on transition 164) and now has data to send or receive.", "An EPS bearer is then set up for this communications device and it is switched to ECM_connected.", "Whenever the communications device is EMM_registered, regardless of the ECM states, the communications device will have an IP address that can be used to reach the communications device, in other words an IP context remains active even if no actual EPS bearer is currently active (e.g.", "state 152).", "If the communications device detaches from the network, for example because it is turned off, moving to a different network, or for any other reason, it will switch from any state it is into state 153, releasing any outstanding EPS bearer or context that was previously maintained for the communications device, via transitions 162 or 163.As can be understood, the state 154 where the communications device is in ECM_connected and in EMM_unregistered is a transient state and the communications device does not generally remain in that particular state.", "A communications device in that state is either a communications device switching from state 153 (detached and inactive) to state 151 (attached and active) or a communications device switching from state 151 to state 153.RRC states are also provided to reflect the status of the RRC connection between the communications device and the eNB (RRC_connected and RRC_idle).", "Under conventional operation conditions, the RRC states correspond to the ECM states: if the communications device is in ECM_connected, it should also be in RRC_connected and if it is in ECM_idle, it should also be in RRC_idle.", "Discrepancies between ECM and RRC states may occur for a short period of time as a connection is being set-up or torn-down.", "An illustration of the states of a communications device 101 which include both the ECM states and the RRC states is illustrated in FIG.", "4.As shown in FIG.", "4 a communications device 101 may start in the RRC Idle/ECM Idle state when the device is off and not being used by the user.", "The off state is therefore represented by a box 201.As soon as the communications device 101 is activated it must connect to the MME 105 in order to perform a tracking area update and to active services to the communications device.", "Accordingly, the communications device moves into an RRC connected state 204 but with the ECM Idle state because an EPS bearer has not yet been established.", "It is only after an EPS bearer has been established that the communications device 101 moves into an RRC connected and ECM connected state 206.A general illustration of the process by which data is communicated via an EPS bearer after a UE moves from an off state to an ECM connected and RRC connected state this shown in FIG.", "5.FIG.", "5 illustrates an example of the messages exchanged for setting up a connection from the communications device 101 to the destination 120, for using the connection to communicate data and for releasing the connection after the communications between the communications device 101 and the destination 120 have been completed.", "The call flow of FIG.", "5 can be schematically divided into four steps A-D. Before step A starts, the communications device 101 is in the ECM_idle state which means that the communications device 101 is not currently communicating.", "At step A (messages 1-3) an RRC connection is set up between the communications device 101 and the eNB 102 for controlling communications between the communications device 101 and the eNB 102.Once this RRC connection has been successfully established, at step B (messages 3-12), the communications device 101 can establish a NAS connection with the MME 105.Following this NAS connection request from the communications device 101 to the MME 105, the MME sets up a connection (e.g.", "EPS bearer) between the communications device 101 and the P-GW 104, via the S-GW 103 and the eNB 102, and controls this connection.", "Although they have not been represented here, messages may also be sent to the P-GW 104, for example from the S-GW 103, for setting up the connection (e.g.", "EPS bearer) at the P-GW 104, for example the GTP tunnel and EPS bearer.", "At the end of step B, the communications device 101 has an EPS bearer set-up and available to send and receive messages and is therefore in the ECM-connected state.", "The call flow of FIG.", "4 is an illustration and some of the messages may vary, for example depending on the EMM state before step A.", "For example, the communications device may be in EMM_unregistered state and switch to EMM_registered during step B, or may already be in EMM_registered before step A starts.", "During step A, a RRC connection is setup between the communications device 101 and the eNB 102.Once this RRC connection has been set up, at time t1, the eNB maintains an RRC context, referred to as Cont_RRC, for the duration of the RRC connection.", "In other words, until the RRC is released, the eNB will maintain this Cont_RRC.", "Such a context may for example include a communications device identifier (e.g.", "C-RNTI), power control settings, mobility settings, security settings, other radio settings or any other information.", "There will also be a corresponding context in the UE storing similar information pertaining to the operation of the radio layers, however, this is not shown in the diagram.", "Once the RRC connection has been set up, a NAS connection is set up between the communications device 101 and the MME 105.Once this NAS connection has been set up, at time t2, the MME 105 maintains a context for this NAS connection to the communications device 101, referred to as Cont_NAS, for the duration of the NAS connection.", "Such a NAS context may for example include a terminal identifier, a terminal's IP address, a current eNB, mobility settings, security settings, QoS settings, or any other information.", "As explained above, when the communications device 101 attaches/sets up a data connection via the mobile network, an EPS bearer is set up in the user plane between the communications device and the P-GW 104, the bearer being controlled in the control plane by the MME 105.There will also be a context in the UE storing UE related information pertaining to the NAS protocol.", "Note that the context Cont_NAS shown in the diagram as being stored at the MME, may include more information than just that used by or transferred in EPC NAS signalling procedures, it may also contain information pertaining to the session which has been gathered by the MME from for example, an HSS.", "Once the RRC connection, the NAS connection and the EPS bearer have been set up, the communications device can send uplink data through the EPS bearer and to the destination.", "Even though in the example of FIG.", "5, the communications device 101 sends uplink data, the same connection setup would occur for a downlink or for an uplink and downlink transmission.", "Likewise the path of an acknowledgement message has been illustrated in the example of FIG.", "5 even though there may not be any acknowledgement message in other examples.", "As discussed earlier, this may for example be dependent upon the type of protocol(s) used for transmitting the data.", "As can be seen in FIG.", "5, Cont_RRC and Cont_NAS are maintained for the duration of the RRC and NAS connection (i.e.", "until they are expressly released with a connection release message exchange) and, as a result, the RRC context is used for every packet that eNB 101 receives from or sends to the communications device 101.Once the EPS bearer can be released, the NAS connection between the communications device 101 and the MME 105 is released at the same time.", "As a result, at the time t3 where the NAS connection is released, the context Cont_NAS is also released.", "The tearing down of the NAS connection is followed by a tearing down of the corresponding RRC connection at time t4.Again, as the RRC connection is released, the context Cont_RRC is also released.", "At a point in time after completion of step C, the resources are released (step D).", "Step D could happen at any time after step C, for example just after message 20, or at a later point in time, for example after the communications device 101 stopped communicating for a predetermined time.", "The aim of step D is to release all unused connections, that is, to release the NAS connection between the MME 105 and the communications device 101 (also leading to the release of resources such as the GTP tunnel between S-GW and eNB and the EPS bearer), and to release the RRC connection between the communications device 101 and the eNB 102.Again, depending on whether the communications device 101 should remain in EMM_registered after step D or should switch to EMM_unregistered, the call flow for step D is likely to be affected.", "For example, the communications device 101 may remain in EMM_registered if the communications device simply releases the RRC connection, NAS connection and EPS bearer because it has been inactive for too long, or the communications device 101 may de-attach from the network and switch to EMM_unregistered (for example following a handover to a GSM network).", "Protocol Stack within Network Elements As will be appreciated from those skilled in the art each of the network elements shown in FIG.", "5 performs various functions in order to establish the EPS bearer and allow the communications device 101 to move from the EPM and RRC Idle states to the ECM connected and RRC connected states.", "This is achieved using various functions performed at each of the different protocol layers in both a user plane protocol stack and a control plane protocol stack.", "The functions performed by each of the network elements are shown in FIG.", "6.As shown in FIG.", "6 the eNodeB 102 includes and intercell radio resource management entity 301, a radio bearer controller 302, a connection management controller 304, a radio admission control 306, an eNodeB measurement configuration and provision entity 308 and a dynamic resource allocation or scheduler 310 which operate for example as explained in 3GPP document TS36.300 to provide radio resources to the communications device and to manage the connection and mobility.", "In respect of the control plane signalling the MME communicates signalling messages to the eNodeB 102 using an NAS security function 320, an Idle state mobility handling 322 and an EPS bearer controller 304.Control plane functions or NAS functions performed by the serving gateway include mobility anchoring 330 as well as UPI address allocation performed by the P-GW 104 340 and packet filtering 342.Correspondingly the protocol stack for the control plane entities illustrated in FIG.", "7 which facilitate the non access stratum (NAS) signalling is supported by a protocol stack which includes a relay resource connection layer 400, a packet data conversions protocol layer 402, a radio link control layer 404, a medium access control layer 406 and the physical layer 408.In contrast the user plane protocol stack is showing in FIG.", "8 where corresponding elements showing in FIG.", "7 are correspondingly labelled.", "As will be appreciated by those skilled in the art, each of the layers in the protocol stack of the user plane and the control plane are required to monitor the current state of the transmission of data at each of the protocol layers in order to maintain for example security and data delivery to form the EPS bearer for communicating packet data from the communications device 101 across the mobile communications network to the destination 120.Stasis State In the event that the communications device 101 has to send and/or receive large amount of data, the connection method described above can be efficient in setting up a high-throughput connection to the P-GW for transmitting such data.", "It is however based on the exchange of a large number of signalling messages between different parties and the setup of a large number of advanced connections (RRC, NAS, EPS, etc), which may render the system inefficient if the communications device's transmission is actually a brief and small transmission, which is likely to be the case for low complexity applications and more simple devices such as an MTC type applications.", "Such devices are likely to require reduced functionality in comparison to conventional communications devices, in order to reduce the cost of producing such devices.", "This is because it is envisaged that such devices will be more ubiquitous and utilitarian than conventional communications devices and therefore should be less expensive to produce in order to be attractive to use mobile communications networks to transmit and receive data.", "However the present disclosure is not limited to such devices and may find applications operating with conventional devices in a different mode.", "Accordingly, the present technique aims to provide an advantage of adapting conventional mobile communications techniques, particularly in respect of data communications in order to reduce an overhead of signalling transmissions and processing with respect to useful data transmitted and a cost of implementing communications devices which use the techniques as provided by an adapted mobile communications network.", "This is because recent networks, including LTE networks, have been designed for high-capabilities and high-mobility communications devices and, as a result, they usually provide for the setup of a high-speed high-reliability connection with an advanced mobility management with a view to supporting communications devices potentially transmitting large amount of data while moving.", "However, in the case of a communications device that is not moving as much as a personal phone and/or transmits only small amount of data on a relatively infrequent basis, the amount of signalling and of mobility tracking required for the communications device to communicate may be excessive.", "In particular, it may be excessive compared to the sometimes low level of service that may be acceptable for this type of communications devices.", "For example MTC communications devices are more delay-tolerant than a human-to-human communications device, are less likely to move and/or to change cell during transmissions and usually send or receive small amount of data.", "It may therefore be desirable to provide ways to improve an efficiency of the network for transmitting small messages and/or MTC communications.", "One example is disclosed in our co-pending UK patent applications numbers 1113145.5, 1113144.8, 1209526.1 and International patent application number PCT/GB2012/051764 the contents of which are incorporated herein by reference.", "According to the present technique embodiments of the present disclosure are arranged such that a mobile communications device which no longer has data to send for a predetermined time enters a stasis state by transmitting a signal to the mobile communications network and more particularly in the present example to an eNodeB 102.Once the eNodeB 102 receives the stasis message then in order to avoid having to perform all of the signalling required to set up an EPS bearer again, the current state of each of the protocol stacks for the current EPS bearer are saved by the eNodeB and other network elements.", "Accordingly, for example the communications device 101 retains the connection identifier which is used by the network to support the RRC connection and ECM connection state such as for example the CRNTI.", "Embodiments of the present technique will be illustrated with reference to a more detailed call flow diagram corresponding to the example showing in FIG.", "5.FIGS.", "9a and 9b illustrate signalling transitions and messages which are required for the communications device 101 to pass from an RRC Idle and ECM Idle state to an RRC connected and ECM connected state back to the ECM Idle and RRC Idle state.", "In FIG.", "9a from a start state, in which the communications device 101 is in the RRC Idle and ECM Idle state 201, the communications device 101 performs a random access procedure 501 in order to request and be granted uplink resources in order to transmit an RRC connection request message 502.The eNode-B 102 responds with a RRC connection set up message 504 and an RRC connection set up complete message.", "At this point the communications device 101 is in the RRC connected but ECM Idle state.", "Following the RRC connection set up complete message, the communications device 101 transmits an attach request/PDM connection request to the eNode-B 102 506.The eNode-B 102 then forwards the attached request/PDN connectivity message 508 to the MME 105 in order to establish an EPS bearer.", "Following transmission of the attached request/PDM connectivity request 508 the MME 105 and the eNodeB 102 and the communications device 105, 102, 101 perform a security procedure 510 in order to authenticate the communications device.", "After this process a context is established for the communications device for the EPS bearer.", "Accordingly, the MME 105 transmits an initial context set up request/attach accept, activate default bearer context request 512 to the eNodeB 102 which then forwards an RRC connection reconfiguration or attach accept/active default bearer message 514.The communications device 101 then transmits an RRC connection reconfiguration complete message 514 and in response the eNodeB 102 transmits and initial context set up response message 516 to the MME 105.The eNodeB 102 transmits an RLC Ack message 518 to the communications terminal 101.The communications device 101 then transmits an uplink information transfer attach complete/active accept message 518 which prompts the eNodeB 102 to transmit an uplink NAS transport (attach complete/active default accept message 520).", "After this message the eNodeB 102 transmits an RLC Ack message 522 at which point the communications device moves to the RRC connected/ECM connected state 206.FIG.", "9b shows the message flow for moving from the RRC connected and ECM connected states to the RRC Idle and ECM Idle states corresponding the call flow diagram showing in FIG.", "9a.", "As shown in FIG.", "9b the communications device 101 is transmitting uplink data using transmission messages 530 which are acknowledged by the eNodeB 102 with a downlink data message 532 providing an RLC Ack.", "The data transmitted on the uplink to the eNodeB 102 is then forwarded to the PGN 104 via the established EPS bearer 534.It then follows a TCP Ack transmitted on the downlink and messages associated with a transmission of acknowledgement of downlink data transmissions 536.After the communications terminal 101 has transmitted an uplink data RLC acknowledgement message 540 which could be the final data transmission for the uplink by the communications device 101, the communications device 101 may determine that there is no more data to send as represented by the box X 542.Only the eNodeB (communication device 102) can release the RRC connection, provided for the communications device 102, using an RRC connection release message by detecting a period of inactivity.", "Releasig the RRC connection will normally be the context at the eNodeB and MME (however this is dependent on network implementation).", "This release follows and exchange of messages 544 to release the RRC connect and also release the communications context of the communications terminal 101 using messages exchanged between the eNodeB and the PGW104.FIG.", "10 provides an example of the present technique in which the communications device 101 includes a new stasis state for the RRC state.", "Thus as shown in FIG.", "10 which corresponds to FIG.", "4, a new stasis state 250 is provided to an adapted communications device 101.As explained above in the new stasis state the state of the protocols within the protocol stack on both the eNode-B 102 and the UE 101 are effectively frozen and stored and the C-RNTI for the UE is saved by the eNodeB pending further communications.", "However, the radio resources are released.", "A state diagram showing the changes of the state by the communications device to reach the stasis state 250 is shown in FIG.", "11, where the states are numbered in correspondence with those of FIGS.", "4 and 10.The message state flow is summarised with respect to the numbering of the state transitions shown in FIG.", "11 as follows: 1.A communications device determines that either it has no more data to transmit on the uplink to the communications network or that it does not expect to receive any further data on the downlink.", "In the former case the communications device will monitor the data buffer containing packet for transition on the uplink.", "In the latter case if the communications device detects that there are no more data packets to send to the communications device 101 then this may be signalled to the communications 101.The point at which the communications device therefore decides that it has no more requirements for communications resources is identified with the point “x” in FIG.", "9b.", "In order to enter the RRC stasis state 250, the communications device 101, whilst in the RRC connected and ECM connected state 206, transmits an RRC stasis request message in state 206 before it can transition to the RRC stasis and ECM connected state 250.2a.", "The communications device then receives and RRC stasis confirm message and moves from the RRC connected/ECM connected state 206 to the RRC stasis and ECM connected state 250.2b.", "In some circumstances the communications device 101 may receive an RRC stasis reject message from the communications network, for example where the communications network finds that it now has data to send to the communications device or if the stasis mode for both the eNode-B and the communications device is not supported by the mobile communications network.", "3.The communications device then decides that it should transmit data for example, as a result of new data being ready to be transmitted in the device's packet data buffer.", "Thus having received a packet for transmission the communications device needs to move back to the RRC connected and ECM connected state 206.Another reason for moving back to the RRC connected and ECM connected state 206 is that measurements performed by the communications device might indicate that it should hand over to another eNode-B in which case a communications device must be in the RRC and ECM connected state 206.4.The communications device initiates the RACH procedure for example the MAC layer transmission described in section 5.1.5 of TS36.321.This essentially involves transmitting random access message using contention access as it conventionally arranged with mobile communications network.", "The PRACH includes the CRNTI which was previously stored by the communications device and by the eNodeB 102.As such when the eNodeB receives the CRNTI of the communications device in the PRACH message the eNodeB can immediately recognise that the communications device transmitted the PRACH message and also recognised that the communications device 102 concerned is currently in the stasis state 250.The eNodeB therefore moves the communications device back to the RRC connected ECM_connected state 206 and transmits an RRC connection re-establishment request message to the communications device 101.5.Therefore on completion of the RACH procedure (RAR received) communications device transmits the RRC connection re-establishment request message to the eNodeB 102.On receipt of the RRC connection of establishment message the communications device has then successfully re-established the RRC connection and moves to the RRC connected/ECM connected state 206.6.If the communications device receives an RRC connection re-establishment reject message then a communications device transitions back to the RRC Idle but ECM connected state 252.A call flow diagram corresponding to the core flow diagrams shown in FIGS.", "9a and 9b but adapted in accordance with the present technique to include the call flow messages associated with a transition to the stasis state 250 is shown in FIG.", "12.FIG.", "12 is now summarised as follows: Starting from the RRC connected/ECM connected state 206 the communications device 101 transmits data packets on the uplink and receives acknowledgment on the downlink or receives downlink data packets and transmits acknowledgements on the uplink as explained with reference to FIGS.", "5, 9a and 9b.", "This effective therefore forms part of section C of the flow diagram of FIG.", "5.At point X in FIG.", "12 the communications device 101 detects that it has no more data packets to transmit and transmits an RRC stasis message request 600.If the communications network can support the new stasis state then the communications network transmits an RRC stasis message confirm message to the communications device 101 as message 602.At this point both the communications device and the eNode-B confirm that the CRNTI the RLC and PDCP sequence numbers and the MAC configuration etc.", "are to be retained and stored so that effectively the EPC bearer moves into a stasis state in that it still exists but there are no packets being transmitted via the EPS bearer.", "Accordingly, when the communications terminal transmits data packets again via the EPS bearer there is no need to re-establish the tunnelling between the various nodes of the communications network in order to establish the EPS bearer.", "The communications device 101 then transmits a RRC stasis ECM connected message 604 to the eNodeB to confirm that it has entered the stasis state.", "Therefore in a period E the communications device has entered the stasis state 250.Whilst in the stasis state 250 the communications device detects that it needs to move back to the RRC connected and ECM connected state 206.This can be to transmit data from the uplink because the communications device detects that it has new packet data to be transmitted.", "Alternatively the network may detect that it may need to transmit on the downlink and therefore signals to the communications device using a conventional paging message that it needs to move back to the RRC connect and ECM connected states.", "Alternatively, the communications terminal which continues to monitor neighbouring base stations and may decide that it needs to hand over to one of the neighbouring base stations as a result of measurement of radio link quality being taken in accordance with a conventional handover arrangement.", "Again, this would require the communications device 101 to move back to the RRC connected/ECM connected state 206.In order for the communications device 101 to move back to the ECM connected/RRC connected state 206, the communications device transits a PRACH message.", "The communications device receives but then discards the C-RNTI assigned via the RAR message 608 and uses the retained C-RNTI.", "The C-RNTI which was retained should not be used by any other communications device.", "Accordingly the eNodeB 102 reserves the C-RNTI for the communications device during a time when the communications device is in the stasis state so that this is not allocated to another communications device in the cell.", "The RRC connection request re-establishment request message 610 sent by the communications terminal 101 includes the retained C-RNTI.", "The RRC connection re-establishment request message may include an indication of a status of the packet communications buffer stasis.", "The eNode-B 102 then transmits and RRC connection re-establishment message 612 to the communications device 101 which responds with an RRC connection re-establishment complete message 614.At this point the communications device has returned to the RRC connected/ECM connected state 206 and transmits data on the uplink in accordance with a conventional operation identified as a phase C shown in FIG.", "5 and also in the first part of FIG.", "12.As will be appreciated by transitioning to the stasis state the communications terminal can release its radio communications resources and enter a power down state thus saving power.", "However, if there is new data to be transmitted communications device does not have to proceed through the entire message exchange shown in FIGS.", "9a and 9b in order to communicate packet data again.", "This is because the stats of the protocol stacks are retained for example the RLC layer and PDCP sequence numbers are maintained as well as the MAC configuration for the communications link.", "In addition on the network side the EPS bearer is also retained and just needs to be reactivated by transmitting data packets in a conventional arrangement.", "Accordingly, it is possible to reduce network resources consumed the result of signalling and reduce an amount of redundant information which is communicated in order to establish the EPS bearer.", "A diagram of an adapted communications device 101 and eNodeB 102 which provides an example embodiment of the present technique is shown in FIG.", "13.As shown in FIG.", "13, a communications device also referred to as a UE 101 comprises a transmitter and receiver unit 701 and a controller 702.The controller 702 controls the transceiver unit 701 in order to transmit and receive data which is fed to a processor 704 which hosts applications programs and other processes for providing user services and for controlling the communications device 101.Data transmitted on the down-link and received for transmission on the up-link by the communications device 101 is fed to a data buffer 706.The data buffer 706 buffers the data packets for transmission on the uplink to the mobile communications network or buffers data packets received on the downlink which are transmitted from and the eNodeB 102 to the communications device 101.As explained above when the communications device enters the stasis state, the state of the protocol stacks including sequence numbers, security keys etc are stored in a data store 708 with a channel identifier such as a C-RNTI.", "This information, which is related to the communications context of the communications device can be used to reactivate the communications context of the communications device 101 which has been used to transmit data packets on the uplink or receive data packets on the downlink via the EPS bearer across the mobile communications network, which is associated with the communications context.", "Also shown in FIG.", "13 is a base station or eNodeB 102, which comprises a transmitter and receiver unit 720 and a controller at 722.An adapted schedulers 724 is used to schedule the allocation of uplink and downlink communications resources in accordance with a conventional operation.", "However in combination with controller 722, when a stasis state message is received from a communications device 701, the controller 722 arranges for the corresponding state of the protocol stack associated with the EPS bearer establish for the communications device to be stored in a data store 726.The communications buffer 728 is provided to buffer data packets received from respective EPS bearers for transmission to communications devices within a cell served by the eNodeB 182.Therefore, as explained above, once a stasis state message is detected by the controller 722, a scheduler 724 releases communications resources allocated to communications terminal 101 which has entered the stasis state and the controller 722 stores the state of the protocol stack including sequence numbers and security keys.", "The controller 722 then arranges to transmit a message to the communications channel 101 indicating a time for which the communications Tamil will remain within the stasis state.", "Summary Aspects of the Stasis State Embodiments of the present technique can provide new RRC state and the provision of an efficient signalling procedure for the rapid transition between the new state and RRC_CONNECTED.", "The new state differs from existing LTE RRC states (see TS 36.300 Section 7.2) in that the RRC context is suspended (i.e.", "it is dormant) until reactivated by the UE the UE is not contactable the RRC context is reactivated via the RACH procedure and re-establishment of the RRC connection network controlled handover is only possible as a result of UE triggered activity related to measurements performed in the new state The UE must reactivate its RRC context (via the RACH procedure and re-establishment of the RRC connection, to change the state to RRC_CONNECTED) in order to transmit data.", "A UE may deactivate its RRC context via RRC signalling when RRC_CONNECTED.", "In this new stasis state: The communication context in the UE and E-UTRAN is maintained; the C_RNTI is maintained the UE remains PMM_CONNECTED RLC and PDCP Sequence Numbers are preserved The MAC configuration is preserved the security context is maintained (security keys/sequence numbers are preserved in order to enable ciphering an integrity protection) E-UTRAN knows the cell which the UE belongs to; Network ability to transmit and/or receive data to/from the UE is suspended; the UE's ability to transmit and/or receive data to/from network is suspended Any dedicated radio resources previously assigned to the UE (e.g.", "PUCCH) are released The UE performs neighbour cell intra-frequency measurements according to the intra frequency neighbour list previously provided (excluding blacklisted cells) Event Reporting is triggered (Event A5) if Srxlev falls below quality threshold1 and a neighbour cell is found which is better than thtreshold2 UE triggers signalling to initiate transition to RRC_CONNECTED when it has data to send or needs to provide a measurement report or expects to receive data (according to information provided by higher layers) The Network (i.e.", "eNB) may buffer any DL data and/or NAS messages and may attempt to deliver on transition to RRC-CONNECTED Network controlled mobility (handover), the network's ability to transmit and/or receive data to/from the UE and the UE's ability to transmit and/or receive data to/from the network is restored on transition to RRC_CONECTED.", "In RRC_CONNECTED/PMM_CONNECTED the UE may send stasis state message when it has no data to send and does not expect to receive any data (X in FIG.", "12).", "In RRC_CONNECTED/PMM_CONNECTED, receipt of stasis state message causes the eNodeB to preserve the UE's current communications context and to maintain the UE's packet tunnel between the eNB and Packet Gateway.", "The MAC configuration, PDCP and RLC states, including sequence numbers and security context (sequence numbers and keys related to ciphering an integrity protection) are then maintained by the eNodeB and UE.", "In RRC_CONNECTED/PMM_CONNECTED, the eNodeB may respond to receipt of stasis state message by sending stasis state eject message to the UE if it does not wish to preserve the UE's current RRC context (as identified by the C-RNTI).", "The eNodeB may send a RRC stasis state confirm message in response to the received stasis state message in order to indicate that the UE's RRC context is suspended/dormant and RRCNewMessageXConfirm will include an Information Element providing timer value TNewState, where TNewState indicating the period of time for which the communication context is maintained.", "The value of TNewState may be configured by the network operator and is would have a value of several hours.", "While TNewStat≠0, the communication context is maintained; the eNB does not rassign the C-RNTI to any other UE and preserves current RLC and PDCP sequence numbers, MAC configuration and security related information and packet tunnel between the eNB and Packet Gateway).", "Whenever TNewStat≤0 then the eNB may end the commications context (i.e.", "it may delete it from its memor).", "If the communication context is ended then the eNB no longer has any knoweldege relating to the UE and may reassign the C-RNTI.", "If stasis state confirm message is received in response to stasis state message sent then the UE enters RRC-stasis state (step E area of FIG.", "12).", "The UE is moved to RRC_stasis state only when it receives RRC stasis state confirm message.", "If it receives a RRC stasis state reject message or if it does not receive any response to the stasis state message then it remains in the state RRC_CONNECTED.", "The support of the RRC stasis state is assumed to be optional in the UE and in the network.", "If the eNodeB does not support RRC_stasis state then the eNodeB will ignore/discard the RRC stasis state message request and will not respond to it.", "If the eNodeB is unable to maintain the communications context (e.g.", "due to processing or memory limitations) then it should send RRC stasis state Reject message in response to a received RRC stasis state Request.", "In RRC_stasis state, the UE continues to monitor its current cell and it may continue to use the intra frequency neighbor list and cell blacklist, provided in RRC_CONNECTED.", "If Srxlev (current cell)<threshold1 then the UE attempts to find a cell in its neighbour list which is not in its blacklist and for which Srxlev (new cell)>threshold2 (threshold1 and threshold2 are assumed to be operator defined and may be stored in the USIM).", "If these conditions are met then this triggers sending of an Even Report (Event A5) to the eNodeB.", "If TNewState expires then the UE moves to RRC_IDLE.", "If the UE has data in its output buffer (buffer status report, application layer data, triggered event report etc.)", "then it follows the Random Access Procedure specified for LTE (see section 5.1 of 36.321) in order to obtain a Timing Advance and an UL Grant.", "The UE discards the C-RNTI provided by the Random Access Response (see Section 5.1.5 of 36.321) and then proceeds to re-establish the RRC connection (according to Section 5.3.7.4 of TS 36.331).", "In some examples applications in terminal devices (laptops etc.)", "initiate communication session establishment with servers and servers do not generally initiate session establishment with terminal devices.", "Embodiments can therefore provide a means of improving utilisation of the use of radio resources in the case where the mobile device (the UE) initiates session establishment with some remote server and has information governing sending/receiving of data to/from the server.", "The disclosure provides a means to enable a UE which occasionally wishes to transmit to or receive small amounts of data to maximise sleep mode (i.e.", "to shut down most of its radio processes).", "Radio processes are switched off when the UE has no data to send and does not expect to receive any data.", "In RRC_NewState most radio processes are switched off while the UEs transmit buffer is empty then the UE monitors only its current cell if the received signal level Srxlev falls below threshold1 then it tries to find a neighbour cell which is not an the blacklist and which has a signal level above threshold2 if suitable is found then this triggers sending an Event Report (so Event Report A5 is placed in the UE's transmit buffer) If the UEs transmit buffer is not empty for a certain time or contains more than a certain number of bytes then radio processes are switched back on and the UE performs the RACH procedure (according to Section 5.1 of 36.321) and obtains a Timing Advance to resynchronize with the eNB and an UL Grant in order to commence transmission of buffered data (the UE continues to reuse the C-TNTI previously assigned, before transition to RRC_stasis state—according to Section 5.1.5 of 36.321) The disclosure has been described with reference to LTE, but may also be applicable in other wireless communication systems, such as UMTS, as well as in both FDD and TDD systems.", "The disclosure can be applied regardless of whether or not DRX functionality is supported, and DRX functionality provides opportunities to optimise sleep during periods of data transmission/reception but is not optimal during long period of inactivity (e.g.", "several minutes).", "Advantages provided by the present technique may depend on the frequency of the occasional data transmissions (e.g.", "every minute, every 5 minutes) and amount of data to be transmitted.", "For example: Greater power saving might be achieved if the UE waited until some threshold is reached—buffer is not empty for a certain time and/or reaches a certain occupancy (numbers of bytes stored).", "The disclosure can find application MTC devices, e.g.", "smart metering, where the UE is stationary and may want to send small amounts of data (e.g.", "100 bytes) every few minutes, every few hours, once per day.", "Various further aspects and features of the present invention are defined in the appended claims.", "As will be appreciated although the example of an LTE communications system has been used to illustrate examples of the present technique, the present disclosure fined equal application with other communications systems.", "Thus although the state ECM connected and EMM connected have been used, other communications systems use the term PMM connected to represent a packet mobility management system which corresponds substantially to the ECM/EMM terminology used in the present disclosure.", "Various further aspects and features of the present disclosure are defined in the appended claims.", "Various combinations of the features of the dependent claims may be made with those of the independent claims other than the specific combinations recited for the claim dependency.", "Embodiments of the present disclosure have been defined largely in terms of reduced capability devices transmitting data via a virtual carrier inserted in a conventional LTE based host carrier.", "However, it will be understood that any suitable device can transmit and receive data for example devices which have the same capability as a conventional LTE type device or devices which have enhanced capabilities.", "The following numbered clauses provide further example aspects and features of the present technique: 1.A communications device for transmitting data to and receiving data from a mobile communications network, the mobile communications network including one or more network elements providing a wireless access interface for communicating with the communications device, the communications device comprising: a transmitter unit configured to transmit signals to the mobile communications network via the wireless access interface provided by the one or more network elements of the mobile communications network, and a receiver unit configured to receive signals from the mobile communications network via the wireless access interface provided by the one or more network elements of the mobile communications network, and a controller configured to control the transmitter unit to transmit one or more signalling messages to the communications network and the receiver unit to receive one or more signalling messages from the communications network to establish a communications context for communicating data packets using a packet communications bearer from the communications device via the mobile communications network, wherein the controller is configured to identify that the communications device can enter a stasis state because no data packets are available for transmission for a predetermined time via the packet communications bearer or there are no data packets to receive via the packet communications bearer, to transmit a stasis state message to the mobile communications network, and to store information relating to the communications context associated with the packet communications bearer in a data store, which stored information can be used by the controller using the transmitter unit and the receiver unit to re-establish the packet communications bearer to transmit and/or receive data packets using the packet communications bearer, the communications device thereby entering the stasis state.", "2.A communications device according to clause 1, wherein the controller is configured upon detecting that the communications device can enter the stasis state to store, with the information relating to the communications context, a network terminal identifier provided to the communications device by the mobile communications network for requesting communications resources when the communications context was established, and upon detecting that the communications device should exit from the stasis state and enter a connected state, the controller is configured with the transmitter to transmit a request to re-connect message to the mobile communications network, the request to connect message including the network terminal identifier, which is recognised by the mobile communications network to re-establish the packet communications bearer.", "3.A communications device according to clause 1 or 2, wherein the controller is configured to store in the data store one or more sequence numbers associated with one or more protocols of a protocol stack which forms the packet communications bearer when entering the stasis state to the effect that, when the communications device moves from the stasis state to the connected state the stored sequence numbers can be restored to the one or more protocols of the protocol stack to transmit or receive signals via the wireless access interface.", "4.A communications device according to clause 3, wherein the information relating to the context which is stored by the controller in the data store includes one or more of a sequence number associated with a radio link control protocol, a packet data communications protocol or a configuration of a medium access control layer.", "5.A communications device according to clause 3 or 4, wherein the information relating to the context which is stored by the controller in the data store includes a sequence number and a cyphering key associated with a sequence context.", "6.A communications device according to any of clauses 1, 2 or 3, wherein the controller in combination with the receiver monitors signals received via the wireless access interface to perform measurements and in accordance with predetermined conditions based on the measurements, the controller in combination with the receiver and the transmitter is configured to re-establish the same packet communications bearer.", "7.A communications device according to clause 6, wherein the measurements performed by the controller determine whether the communications device should handover from a base station to which the communications device is attached to another base station to transmit and/or receive data packets via the same packet communications bearer, the communications device thereby entering the connected state from the stasis state.", "8.A method of transmitting data to and/or receiving data from a mobile communications network from a communications device, the mobile communications network including one or more network elements providing a wireless access interface for communicating with the communications device, the method comprising: transmitting one or more signalling messages to the mobile communications network, and receiving one or more signalling messages from the communications network to establish a communications context for communicating data packets using a packet communications bearer from the communications device via the mobile communications network, identifying that the communications device can enter a stasis state because no data packets are available for transmission for a predetermined time via the packet communications bearer or there are no data packets to receive via the packet communications bearer, transmitting a stasis state message to the mobile communications network, and storing information relating to the communications context associated with the packet communications bearer in a data store, which stored information can be used by the controller using the transmitter unit and the receiver unit to re-establish the packet communications bearer to transmit and/or receive data packets using the packet communications bearer, the communications device thereby entering the stasis state.", "9.A method according to clause 8, the storing information relating to the communications context associated with the packet communications bearer in a data store, comprises storing, with the information relating to the communications context, a network terminal identifier provided to the communications device by the mobile communications network for requesting communications resources when the communications context was established, and upon detecting that the communications device should exit from the stasis state and enter a connected state, transmitting a request to re-connect message to the mobile communications network, the request to connect message including the network terminal identifier, which is recognised by the mobile communications network to re-establish the packet communications bearer.", "10.A method according to clause 8 or 9, wherein the storing information relating to the communications context associated with the packet communications bearer in a data store, comprises storing in the data store one or more sequence numbers associated with one or more protocols of a protocol stack which forms the packet communications bearer when entering the stasis state to the effect that, when the communications device moves from the stasis state to the connected state the stored sequence numbers can be restored to the one or more protocols of the protocol stack to transmit or receive signals via the wireless access interface." ] ]
Patent_15874369
[ [ "COMPOSITE CABLE AND COMPOSITE HARNESS", "A composite cable includes a first twisted-pair wire formed by twisting a pair of first electric wires, a second twisted-pair wire formed by twisting a pair of second electric wires, a pair of third electric wires arranged between the first and second twisted-pair wires in a circumferential direction, each third electric wire having a larger outer diameter than the first and second electric wires, and a tape member spirally wound around an assembled article that is formed by twisting the first twisted-pair wire, the second twisted-pair wire and the pair of third electric wires together.", "The two twisted-pair wires have the same twist direction, the twist direction of the two twisted-pair wires is different from a twist direction of the assembled article, and the twist direction of the assembled article is different from a winding direction of the tape member." ], [ "1.A composite cable, comprising: a first twisted-pair wire formed by twisting a pair of first electric wires, each first electric wire comprising a first center conductor and a first insulation covering the first center conductor; a second twisted-pair wire formed by twisting a pair of second electric wires, each second electric wire comprising a second center conductor and a second insulation covering the second center conductor; a pair of third electric wires, each third electric wire having a larger outer diameter than the first and second electric wires and comprising a third center conductor with a larger cross-sectional area than the first and second center conductors and a third insulation covering the third center conductor; and a tape member spirally wound around an assembled article that is formed by twisting the first twisted-pair wire, the second twisted-pair wire and the pair of third electric wires together and being in contact with the first twisted-pair wire, the second twisted-pair wire and the pair of third electric wires, wherein the first twisted pair wire and the second twisted pair wire are arranged to be opposite to each other with respect to a straight line connecting between centers of the pair of third electric wires, wherein the two twisted-pair wires have the same twist direction, the twist direction of the two twisted-pair wires is different from a twist direction of the assembled article, and the twist direction of the assembled article is different from a winding direction of the tape member.", "2.The composite cable according to claim 1, wherein a portion of the first twisted pair and a portion of the second twisted pair are located between the pair of third electric wires.", "3.The composite cable according to claim 1, wherein a thickness of the first insulation and a thickness of the second insulation are thinner than a thickness of the third insulation.", "4.The composite cable according to claim 2, wherein a thickness of the first insulation and a thickness of the second insulation are thinner than a thickness of the third insulation.", "5.The composite cable according to claim 1, wherein an outer diameter of the assembled article is 5 mm to 9 mm.", "6.The composite cable according to claim 5, wherein a width of the tape member is 20 mm to 50 mm.", "7.The composite cable according to claim 1, wherein a twist pitch of the two twisted-pair wires is smaller than a twist pitch of the assembled article, and a winding pitch of the tape member is smaller than the twist pitch of the assembled article and is not less than the twist pitches of the two twisted-pair wires.", "8.The composite cable according to claim 2, wherein a twist pitch of the two twisted-pair wires is smaller than a twist pitch of the assembled article, and a winding pitch of the tape member is smaller than the twist pitch of the assembled article and is not less than the twist pitches of the two twisted-pair wires.", "9.The composite cable according to claim 3, wherein a twist pitch of the two twisted-pair wires is smaller than a twist pitch of the assembled article, and a winding pitch of the tape member is smaller than the twist pitch of the assembled article and is not less than the twist pitches of the two twisted-pair wires.", "10.The composite cable according to claim 6, wherein a twist pitch of the two twisted-pair wires is smaller than a twist pitch of the assembled article, and a winding pitch of the tape member is smaller than the twist pitch of the assembled article and is not less than the twist pitches of the two twisted-pair wires.", "11.The composite cable according to claim 6, wherein the tape member is spirally wound around the assembled article so as to overlap at a portion in a width direction and an overlap width of the tape member is not less than ¼ and not more than ½ of a width of the tape member." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The composite cable disclosed by JP-A-2014-135153 has a problem that when terminating the cable, a lubricant such as talc powder may be scattered in a workplace so that the working environment deteriorates.", "It is an object of the invention to provide a composite cable and a composite harness that prevent the deterioration of the working environment during the cable termination while securing the flex resistance.", "According to an embodiment of the invention, a composite cable comprises: a first twisted-pair wire formed by twisting a pair of first electric wires, each first electric wire comprising a first center conductor and a first insulation covering the first center conductor; a second twisted-pair wire formed by twisting a pair of second electric wires, each second electric wire comprising a second center conductor and a second insulation covering the second center conductor; a pair of third electric wires arranged between the first and second twisted-pair wires in a circumferential direction, each third electric wire having a larger outer diameter than the first and second electric wires and comprising a third center conductor with a larger cross-sectional area than the first and second center conductors and a third insulation covering the third center conductor; and a tape member spirally wound around an assembled article that is formed by twisting the first twisted-pair wire, the second twisted-pair wire and the pair of third electric wires together, wherein the two twisted-pair wires have the same twist direction, the twist direction of the two twisted-pair wires is different from a twist direction of the assembled article, and the twist direction of the assembled article is different from a winding direction of the tape member.", "According to another embodiment of the invention, a composite harness comprises: the composite cable mentioned above, and a connector attached to at least one of end portions of the first electric wires, of the second electric wires and of the third electric wires." ], [ "The present application is a Continuation Application under 35 USC § 120 of U.S. application Ser.", "No.", "15/447,819, filed Mar.", "2, 2017, which is based on Japanese patent application No.2016-045447 filed on Mar.", "9, 2016.These prior applications are hereby incorporated in their entirety by reference.", "BACKGROUND OF THE INVENTION 1.Field of the Invention The invention relates to a composite cable and a composite harness and, in particular, to a composite cable and a composite harness which are used in a vehicle such as automobile for connection between a wheel side and a vehicle body side.", "2.Description of the Related Art In recent years, electrically operated brake units are used in vehicles such as automobiles.", "Electro-mechanical brakes (EMB) and electric parking brakes (EPB) are known as such electrically operated brake units.", "The electro-mechanical brakes, also simply called electric friction brake or electric brake, are configured such that a rotational drive force of a dedicated electric motor mounted on each wheel of a vehicle is controlled according to the operation amount (tread force or displacement amount) of a brake pedal by a driver, so that a piston driven by the electric motor presses brake pads against a disc rotor of the wheel to generate a braking force intended by the driver.", "The electric parking brakes are configured such that a dedicated electric motor provided on each wheel of a vehicle is driven based on an operation performed on a parking brake activation switch by a driver after stopping a vehicle, so that a piston driven by the electric motor presses brake pads against a disc rotor of the wheel to generate a braking force.", "Meanwhile, in recent years, sensors, e.g., ABS (Anti-Lock Brake System) sensor for detecting the speed of a wheel rotation during motion, air pressure sensor for detecting air pressure of a tire and temperature sensor, etc., are often mounted on wheels of vehicles.", "Accordingly, the wheel side and the vehicle body side are connected through composite cables in which a signal line for a sensor mounted on a wheel and/or a signal line for controlling an electro-mechanical brake and a power line for supplying power to an electric motor of electro-mechanical brake or electric parking brake are housed in one sheath.", "The composite cables with connectors integrally provided at end portions are called composite harness.", "JP-A-2014-135153 discloses a composite cable in which a lubricant such as talc powder is interposed between plural electric wires and a sheath covering all the plural electric wires together such that friction between the electric wires and the sheath is reduced to reduce stress applied to the electric wires when being bent and a flex resistance is thereby improved.", "SUMMARY OF THE INVENTION The composite cable disclosed by JP-A-2014-135153 has a problem that when terminating the cable, a lubricant such as talc powder may be scattered in a workplace so that the working environment deteriorates.", "It is an object of the invention to provide a composite cable and a composite harness that prevent the deterioration of the working environment during the cable termination while securing the flex resistance.", "According to an embodiment of the invention, a composite cable comprises: a first twisted-pair wire formed by twisting a pair of first electric wires, each first electric wire comprising a first center conductor and a first insulation covering the first center conductor; a second twisted-pair wire formed by twisting a pair of second electric wires, each second electric wire comprising a second center conductor and a second insulation covering the second center conductor; a pair of third electric wires arranged between the first and second twisted-pair wires in a circumferential direction, each third electric wire having a larger outer diameter than the first and second electric wires and comprising a third center conductor with a larger cross-sectional area than the first and second center conductors and a third insulation covering the third center conductor; and a tape member spirally wound around an assembled article that is formed by twisting the first twisted-pair wire, the second twisted-pair wire and the pair of third electric wires together, wherein the two twisted-pair wires have the same twist direction, the twist direction of the two twisted-pair wires is different from a twist direction of the assembled article, and the twist direction of the assembled article is different from a winding direction of the tape member.", "According to another embodiment of the invention, a composite harness comprises: the composite cable mentioned above, and a connector attached to at least one of end portions of the first electric wires, of the second electric wires and of the third electric wires.", "Effects of the invention According to an embodiment of the invention, a composite cable and a composite harness can be provided that prevent the deterioration of the working environment during the cable termination while securing the flex resistance.", "BRIEF DESCRIPTION OF THE DRAWINGS Next, the present invention will be explained in more detail in conjunction with appended drawings, wherein: FIG.", "1 is a block diagram illustrating a configuration of a vehicle in which a composite cable in an embodiment of the present invention is used; FIG.", "2A is a cross sectional view showing the composite cable in the embodiment of the invention; FIG.", "2B is an explanatory diagram illustrating twist directions of two twisted-pair wires and third electric wires and a winding direction of a tape member in the composite cable; and FIG.", "3 is a schematic configuration diagram illustrating a composite harness in the embodiment of the invention.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Embodiment An embodiment of the invention will be described below in conjunction with the appended drawings.", "Description of Vehicle in which Composite Cable is Used FIG.", "1 is a block diagram illustrating a configuration of a vehicle in which a composite cable in the present embodiment is used.", "As shown in FIG.", "1, a vehicle 100 is provided with an electric parking brake (hereinafter, referred to as “EPB”) 101 as an electrically operated brake unit.", "The EPB 101 is provided with an EPB motor 101a and an EPB control unit 101b.", "The EPB motor 101a is a wheel-side device mounted on a wheel 102 of the vehicle 100.The EPB control unit 101b is mounted on an ECU (electronic control unit) 103 which is a vehicle body-side device of the vehicle 100.Alternatively, the control unit 101b may be mounted on a control unit other than the ECU 103, or may be mounted on a dedicated hardware unit.", "The EPB motor 101a is provided with a piston to which brake pads are attached even though it is not illustrated, and it is configured such that the piston moved by rotary drive of the EPB motor 101a presses the brake pads against a disc rotor of a wheel (the wheel 102) to generate a braking force.", "A pair of third electric wires 6 as power lines are connected to the EPB motor 101a to supply a drive current to the EPB motor 101a.", "The EPB control unit 101b is configured to output a drive current to the EPB motor 101a for a predetermined period of time (e.g., for 1 second) when a parking brake activation switch 101c is turned from an OFF state to an ON state during the stationary state of the vehicle 100 such that the brake pads are pressed against the disc rotor of the wheel 102 and a braking force to be applied to the wheel 102 is generated.", "The EPB control unit 101b is also configured to output a drive current to the EPB motor 101a when the parking brake activation switch 101c is turned from the ON state to the OFF state or when an accelerator pedal is depressed such that the brake pads move away from the disc rotor of the wheel and the braking force on the wheel 102 is released.", "In other words, it is configured such that an operating state of the EPB 101 is maintained from when the parking brake activation switch 101c is turned on to when the parking brake activation switch 101c is turned off or the accelerator pedal is depressed.", "The parking brake activation switch 101c may be a switch of either a lever-type or pedal-type.", "An ABS device 104 is also mounted on the vehicle 100.The ABS device 104 is provided with an ABS sensor 104a and an ABS control unit 104b.", "The ABS sensor 104a is a rotational speed sensor mounted on the wheel 102 to detect a rotation speed of the wheel 102 during motion of the vehicle.", "The ABS control unit 104b is mounted on the ECU 103 to control a brake unit based on an output of the ABS sensor 104a to adjust a braking force applied to the wheel 102 such that the wheel 102 is not locked when suddenly stopped.", "A pair of first electric wires 2 as signal lines is connected to the ABS sensor 104a.", "An air pressure sensor 108 for sensing air pressure of a tire (not shown) of the wheel 102 is also provided on the wheel 102 of the vehicle 100.A pair of second electric wires 4 as signal lines is connected to the air pressure sensor 108.An air pressure detection portion 109 for detecting air pressure of the tire based on an output of the air pressure sensor 108 is mounted on the ECU 103.A composite cable 1 in the present embodiment is obtained by covering the first electric wires 2, the second electric wires 4 and the third electric wire 6 with one sheath 9 (see FIGS.", "2A and 2B).", "The composite cable 1 extending out of the wheel 102 side is connected to a wire group 107 inside a junction box 106 provided on a vehicle body 105 and is then connected to the ECU 103 and a battery (not shown) via the wire group 107.Although only one wheel 102 is shown in FIG.", "1 to simplify the drawing, the EPB motor 101a, the ABS sensor 104a and the air pressure sensor 108 may be mounted on each of the wheels 102 of the vehicle 100, or may be mounted on, e.g., only front wheels or only rear wheels of the vehicle 100.Description of the Composite Cable 1 FIG.", "2A is a cross sectional view showing the composite cable 1 in the present embodiment and FIG.", "2B is an explanatory diagram illustrating twist directions of two twisted-pair wires and third electric wires and a winding direction of a tape member.", "As shown in FIGS.", "2A and 2B, the composite cable 1 is provided with a first twisted-pair wire 3 formed by twisting a pair of first electric wires 2 together, a second twisted-pair wire 5 formed by twisting a pair of second electric wires 4 together, a pair of third electric wires 6 having a larger outer diameter than the first electric wires 2 and the second electric wires 4, a tape member 8 spirally wound around an assembled article 7 which is formed by twisting the first twisted-pair wire 3, the second twisted-pair wire 5 and the pair of third electric wires 6 together, and a sheath 9 covering the tape member 8.In the present embodiment, the first electric wire 2 is constructed using a signal line for the ABS sensor 104a mounted on the wheel 102.The first electric wire 2 has a first center conductor 21 and a first insulation 22 covering the first center conductor 21.The first center conductor 21 is constructed from a stranded conductor formed by twisting highly conductive strands of copper, etc., and the first insulation 22 is formed of an insulating resin such as cross-linked polyethylene.", "Strands having a diameter of not less than 0.05 mm and not more than 0.30 mm can be used to form the first center conductor 21.When using strands having a diameter of less than 0.05 mm, sufficient mechanical strength may not be obtained, causing a decrease in flex resistance.", "When using strands having a diameter of more than 0.30 mm, flexibility of the composite cable 1 may decrease.", "Meanwhile, the second electric wire 4 in the present embodiment is constructed using a signal line for the air pressure sensor 108 mounted on the wheel 102.The second electric wire 4 has a second center conductor 41 and a second insulation 42 covering the second center conductor 41.The second center conductor 41 is constructed from a stranded conductor formed by twisting highly conductive strands of copper, etc., and the second insulation 42 is formed of an insulating resin such as cross-linked polyethylene.", "Strands having a diameter of not less than 0.05 mm and not more than 0.30 mm can be used to form the second center conductor 41, in the same manner as the first center conductor 21.In addition, the third electric wire 6 in the present embodiment is constructed using a power line for supplying a drive current to the motor 101a for the EPB 101 mounted on the wheel 102 of the vehicle 100.The third electric wire 6 has a third center conductor 61 and a third insulation 62 covering the third center conductor 61.The third center conductor 61 is constructed from a stranded conductor formed by twisting highly conductive strands of copper, etc., and the third insulation 62 is formed of an insulating resin such as cross-linked polyethylene.", "Strands having a diameter of not less than 0.05 mm and not more than 0.30 mm can be used to form the third center conductor 61, in the same manner as the first center conductor 21 and the second center conductor 41.The cross sectional area (the conductor cross-sectional area) of the third center conductor 61 and the thickness of the third insulation 62 in the third electric wire 6 are appropriately adjusted according to magnitude of required drive current.", "In the present embodiment, since the first electric wire 2 and the second electric wire 4 are used as signal lines and the third electric wire 6 is used as a power line, the cross sectional area (the conductor cross-sectional area) of the third center conductor 61 is larger than that of the first center conductor 21 and the second center conductor 41.In the present embodiment, considering that the third electric wire 6 is a power line for supplying a drive current to the EPB motor 101a, the outer diameter of the third center conductor 61 is set to not less than 1.5 mm and not more than 3.0 mm and the outer diameter of the third electric wire 6 is set to not less than 2.0 mm and not more than 4.0 mm.", "The outer diameter of the third electric wire 6 is larger than that of the first electric wire 2 and the second electric wire 4.In the present embodiment, the first twisted-pair wire 3 formed by twisting a pair (two) of first electric wires 2 and the second twisted-pair wire 5 formed by twisting a pair (two) of second electric wires 4 are twisted with the pair of third electric wires 6 to form the assembled article 7.Therefore, from the viewpoint of making the outer diameter of the composite cable 1 close to a circular shape, it is desirable to use the first electric wire 2 and the second electric wire 4 which are about half the outer diameter of the third electric wire 6.In detail, it is possible to use the first electric wire 2 and the second electric wire 4 which have an outer diameter of not less than 1.0 mm and not more than 1.8 mm.", "The first electric wire 2 used in this example has the first center conductor 21 with a conductor cross-sectional area of not less than 0.13 cm2 and not more than 0.30 cm2, and the second electric wire 4 used in this example has the second center conductor 41 with a conductor cross-sectional area of not less than 0.30 cm2 and not more than 0.50 cm2.Although the conductor cross-sectional area is larger in the second electric wire 4 than in the first electric wire 2 in the present embodiment, the both electric wires 2 and 4 may have the same conductor cross-sectional area.", "From the viewpoint of making the cross sectional shape of the composite cable 1 closer to a circular shape, it is desirable that the outer diameters of the two electric wires 2 and 4 be substantially the same (e.g., a difference in outer diameter between the two electric wires 2 and 4 is within 20% of the outer diameter of the first electric wire 2).", "A twist pitch P1 of the first twisted-pair wire 3 and a twist pitch P2 of the second twisted-pair wire 5 are set by taking into account the outer diameter of the first electric wire 2 and the second electric wire 4 such that an unnecessary load is not applied to the first electric wires 2 and the second electric wires 4.The twist pitches P1 and P2 of the two twisted-pair wires 3 and 5 here are about 30 mm, but the twist pitches P1 and P2 of the two twisted-pair wires 3 and 5 are not limited thereto.", "The twist pitches P1 and P2 of the two twisted-pair wires 3 and 5 may alternatively be different from each other.", "The twist pitch P1 of the first twisted-pair wire 3 is a distance along a longitudinal direction of the first twisted-pair wire 3 between points at which a given first electric wire 2 is located at the same position in a circumferential direction of the first twisted-pair wire 3.Likewise, the twist pitch P2 of the second twisted-pair wire 5 is a distance along a longitudinal direction of the second twisted-pair wire 5 between points at which a given second electric wire 4 is located at the same position in a circumferential direction of the second twisted-pair wire 5.The assembled article 7 is formed by twisting the first twisted-pair wire 3, the second twisted-pair wire 5 and the pair of third electric wires 6.In the present embodiment, each third electric wire 6 is arranged between the first twisted-pair wire 3 and the second twisted-pair wire 5 in a circumferential direction.", "In the cross section shown in FIG.", "2A, the second twisted-pair wire 5, one of the third electric wires 6, the first twisted-pair wire 3 and the other third electric wire 6 are arranged clockwise in this order.", "When the third electric wires 6 are arranged adjacent to each other in the circumferential direction (when the two twisted-pair wires 3 and 5 are arranged adjacent to each other), the center of gravity of the assembled article 7 largely shifts from the center position of the assembled article 7, and the assembled article 7 formed by twisting the two twisted-pair wires 3 and 5 and the third electric wires 6 in such a state is entirely distorted.", "In this case, it is difficult to manufacture a straight composite cable 1 and there is also a problem that the cable has some unbendable portions in a longitudinal direction, resulting in a decrease in flexibility.", "By arranging the third electric wires 6 between the first twisted-pair wire 3 and the second twisted-pair wire 5 in the circumferential direction as in the present embodiment, it is possible to easily realize the straight composite cable 1 and also to suppress a decrease in flexibility since a defect such as unbendable portions in the longitudinal direction is prevented from occurring.", "Furthermore, in the present embodiment, the assembled article 7 is configured such that plural thread-shaped (fibrous) fillers 10 extending in the longitudinal direction of the composite cable 1 are arranged between the first twisted-pair wire 3/the second twisted-pair wire 5/the pair of third electric wires 6 and the tape member 8 and are twisted together with the two twisted-pair wires 3 and 5 and the third electric wires 6.Thus, the twist direction and twist pitch of the plural fillers 10 are the same as those of the assembled article 7.The plural fillers 10 are arranged to fill a gap between the two twisted-pair wires 3 and 5/the third electric wires 6 and the tape member 8, so that a cross sectional shape after winding the tape member 8 around the assembled article 7 is closer to a circle.", "In this regard, some of the plural fillers 10 may be arranged in triangle boundary areas between the two twisted-pair wires 3 and 5 and the third electric wires 6, triangle boundary areas between the pair of first electric wires 2 and triangle boundary areas between the pair of second electric wires 4.As the filler 10, it is possible to use a fibrous material such as polypropylene yarn, spun rayon yarn (rayon staple fiber), aramid fiber, nylon fiber or fiber plastic, a paper or a cotton yarn.", "In addition, the cross sectional area of the fillers 10 on the cross section of FIG.", "2A is preferably larger than the total cross-sectional area of the electric wires 2, 4 and 6 (the sum of the cross-sectional area of the first electric wires 2, the cross-sectional area of the second electric wires 4 and the cross-sectional area of the third electric wires 6).", "In the EPB 101, a drive current is supplied for a short time when the parking brake activation switch 101c is operated and an effect of noise on the first electric wire 2 and the second electric wire 4 used as signal lines is small.", "Therefore, in the present embodiment, a shield conductor around the third electric wires 6 or the twisted-pair wires 3 and 5 is omitted.", "Omitting the shield conductor allows the composite cable 1 to have a smaller outer diameter than when providing the shield conductor and also reduces the number of components, thereby reducing the cost.", "In addition, in the present embodiment, the first twisted-pair wire 3 transmitting an electrical signal during motion of the vehicle and the second twisted-pair wire 5 also transmitting an electrical signal during motion of the vehicle are separated by the pair of third electric wires 6 which supply a drive current to the EPB 101 mainly after the vehicle is stopped.", "This can reduce crosstalk between the first twisted-pair wire 3 and the second twisted-pair wire 5 even when shield conductors around the twisted-pair wires 3 and 5 are omitted.", "Although the third electric wire 6 for supplying a drive current to the EPB motor 101a is described here, the third electric wire 6 may be used to supply a drive current to, e.g., an electric motor of an electro-mechanical brake (hereinafter, referred to as EMB) provided on the wheel 102.In this case, since a drive current often flows through the third electric wire 6, it is desirable to provide a shield conductor around the twisted-pair wires 3 and 5 (or around each of the electric wires 2 and 4) to reduce the effect of noise on the first electric wires 2 and the second electric wires 4 which are used as signal lines.", "Meanwhile, although the first electric wire 2 as a signal line for the ABS sensor 104a and the second electric wire 4 as a signal line for the air pressure sensor 108 are described here, each of the first electric wire 2 and the second electric wire 4 may be a signal line used for another sensor provided on the wheel 102, e.g., for a temperature sensor, etc., or may be a damper wire used to control a damping device of the vehicle 100, or moreover, may be a signal line for controlling the EMB (a CAN cable, etc.).", "The outer diameter of the entire assembled article 7 is, e.g., about 5 mm to 9 mm.", "A twist pitch P3 of the assembled article 7 is set by taking into account the outer diameter of the assembled article 7 such that an unnecessary load is not applied to the twisted-pair wires 3 and 5 and the third electric wires 6.The twist pitch P3 of the assembled article 7 here is about 60 mm, but the twist pitch P3 of the assembled article 7 is not limited thereto.", "The twist pitch P3 of the assembled article 7 is a distance along a longitudinal direction of the assembled article 7 between points at which a given the twisted-pair wire 3, 5 or third electric wire 6 is located at the same position in a circumferential direction of the assembled article 7.The tape member 8 is spirally wound around the assembled article 7 so as to be in contact with all electric wires (the pair of first electric wires 2, the pair of second electric wires 4 and the pair of third electric wires 6) covered with the tape member 8.The tape member 8 is interposed between the assembled article 7 and the sheath 9 and serves to reduce friction between the assembled article 7 (the electric wires 2, 4 and 6) and the sheath 9 when being bent.", "In other words, providing the tape member 8 can reduce friction between the electric wires 2, 4, 6 and the sheath 9 without using a lubricant such as talc powder unlike the conventional technique, and thus reduces stress applied to the electric wires 2, 4 and 6 when being bent, and it is thereby possible to improve flex resistance.", "The tape member 8 is desirably slidable (desirably has a low friction coefficient) with respect to the first insulation 22 of the first electric wire 2, the second insulation 42 of the second electric wire 4 and the third insulation 62 of the third electric wire 6, and can be formed of, e.g., a non-woven fabric, a paper or a resin (a resin film, etc.).", "In more detail, a material of the tape member 8 is selected such that the friction coefficient (coefficient of static friction) between the tape member 8 and the insulations 22, 42, 62 is lower than the friction coefficient (coefficient of static friction) between the sheath 9 and the insulations 22, 42, 62 without interposition of the tape member 8.It is also possible to use the tape member 8 having a laminated structure composed of not less than two layers.", "In this case, the tape member 8 is configured such that a surface to be in contact with the assembled article 7 is formed of any one of a non-woven fabric, a paper or a resin layer.", "For example, it can be configured such that the tape member 8 is formed by providing a resin layer on one side of a paper and is wound with the resin layer having a lower friction coefficient on the assembled article 7 side.", "The tape member 8 is spirally wound around the assembled article 7 so as to overlap at a portion in a width direction (a direction perpendicular to the longitudinal direction and thickness direction of the tape member 8).", "The overlap width of the tape member 8 is, e.g., not less than ¼ and not more than ½ of the width of the tape member 8.In the present embodiment, the overlapping portion of the tape member 8 is not adhered by an adhesive, etc.", "The width of the tape member 8 is determined such that creases are not formed on the tape member 8 when the tape member 8 is wound, and it is desirable that the width of the tape member 8 to be used be decreased with a decrease in the outer diameter of the entire assembled article 7.In detail, when the outer diameter of the assembled article 7 is 5 mm to 9 mm, the width of the tape member 8 is about 20 mm to 50 mm.", "A winding pitch P4 of the tape member 8, i.e., a distance along a longitudinal direction between points on the tape member 8 at the same circumferential position (e.g., a distance between the widthwise edges), depends on the width of the tape member 8 and the overlap width (a winding angle of the tape member 8) and is up to about 40 mm in this case.", "The winding pitch P4 of the tape member 8 here is about 30 mm, but the winding pitch P4 of the tape member 8 is not limited thereto.", "When the width of the tape member 8 is increased and the winding pitch P4 is also increased, the tape member 8 becomes close to the longitudinally wrapped state, resulting in that the composite cable 1 has less flexibility and is less likely to be bent.", "Therefore, the winding pitch P4 of the tape member 8 is desirably not more than 40 mm.", "The sheath 9 is provided around the tape member 8.The sheath 9 is formed of, e.g., a urethane resin.", "Although a shield conductor around the tape member 8 is omitted in the present embodiment since the third electric wires 6 are used to supply a drive current to the EPB motor 101a and the drive current flows through the third electric wires 6 in a relatively short time, a shield conductor may be provided between the tape member 8 and the sheath 9 or around the sheath 9 depending on the intended use, etc., of the third electric wires 6.Twist Directions of the Twisted-Pair Wires 3, 5 and the Assembled Article 7, and Winding Direction of the Tape Member 8 The composite cable 1 of the present embodiment is configured such that the two twisted-pair wires 3 and 5 have the same twist direction, the twist direction of the two twisted-pair wires 3 and 5 is different from the twist direction of the assembled article 7, and the twist direction of the assembled article 7 is different from the winding direction of the tape member 8.In other words, in the composite cable 1, the twist direction of the two twisted-pair wires 3 and 5 and the winding direction of the tape member 8 are the same direction and only the twist direction of the assembled article 7 is different.", "The twist direction here is a direction that the electric wires 2, 4 and 6 rotate from the base end toward the front end when the composite cable 1 is viewed from the front end side (the left side of FIG.", "2B, on the side where the tape member 8 overlaps upon itself).", "In this example, the twist direction of the twisted-pair wires 3 and 5 and the twist direction of the assembled article 7 are the right rotation (clockwise).", "The twist direction of the twisted-pair wires 3 and 5 is a direction of twisting two electric wires 2 or 4 and the twist direction of the assembled article 7 is a direction of twisting the twisted-pair wires 3 and 5 and the third electric wires 6.Meanwhile, the winding direction of the tape member 8 is a direction that the tape member 8 rotates from the base end toward the front end when the composite cable 1 is viewed from the front end side (the left side of FIG.", "2B, on the side where the tape member 8 overlaps upon itself).", "In this example, the winding direction of the tape member 8 is the right rotation (clockwise).", "The cross section as viewed from the front end side is shown in FIG.", "2A in which the twist direction of the first twisted-pair wire 3 is indicated by a dashed arrow A, the twist direction of the second twisted-pair wire 5 is indicated by a dashed arrow B, the twist direction of the assembled article 7 is indicated by a dashed arrow C and the winding direction of the tape member 8 is indicated by a dashed arrow D. In general, when twisting electric wires together or spirally winding a tape, a kink is formed according to the twist direction or the winding direction and the entire cable curves spontaneously.", "In the present embodiment, the twist direction of the twisted-pair wires 3 and 5 is different from the twist direction of the assembled article 7 and also the twist direction of the assembled article 7 is different from the winding direction of the tape member 8.Therefore, the kink of the twisted-pair wires 3 and 5 and the kink of the assembled article 7 are in the opposite directions and thus cancel out each other, and also, the kink of the assembled article 7 and the kink caused by winding the tape member 8 are in the opposite directions and thus cancel out each other, and it is thereby possible to easily realize a straight composite cable 1 which is prevented from kinking up.", "As a result, it is possible to reduce variation in bending properties in the longitudinal direction of the composite cable 1.In case that the twist direction of the twisted-pair wires 3 and 5 is the same as the twist direction of the assembled article 7, the twisted-pair wires 3 and 5 may be distorted in a direction of tightening the twist when twisting the assembled article 7, causing a change in the twist pitches P1 and P2 of the twisted-pair wires 3 and 5.Differing the twist direction of the twisted-pair wires 3 and 5 from the twist direction of the assembled article 7 allows the assembled article 7 to be formed while suppressing a change in the twist pitches P1 and P2 of the twisted-pair wires 3 and 5.In this regard, however, if the twist pitches P1 and P2 of the twisted-pair wires 3 and 5 are large, the twists of the twisted-pair wires 3 and 5 may loosen when twisting the assembled article 7.Therefore, the twist pitches P1 and P2 of the twisted-pair wires 3 and 5 are desirably smaller than at least the twist pitch P3 of the assembled article 7.In other words, when the twist direction of the twisted-pair wires 3 and 5 is different from the twist direction of the assembled article 7, adjusting the twist pitches P1 and P2 of the twisted-pair wires 3 and 5 to smaller than the twist pitch P3 of the assembled article 7 allows the twists of the twisted-pair wires 3 and 5 to be less likely to unravel and it is thereby possible to stabilize the cross sectional shape of the assembled article 7.In the present embodiment, since the kink caused by winding the tape member 8 is used to straighten the kink of the assembled article 7, the winding pitch P4 of the tape member 8 needs to be small enough to cause a kink.", "Therefore, the winding pitch P4 of the tape member 8 is desirably smaller than at least the twist pitch P3 of the assembled article 7.In the present embodiment, the twist pitches P1 and P2 of the twisted-pair wires 3 and 5 are about 30 mm, the twist pitch P3 of the assembled article 7 is about 60 mm and the winding pitch P4 of the tape member 8 is about 30 mm.", "The winding pitch P4 of the tape member 8 only needs to be not less than the twist pitches P1 and P2 of the twisted-pair wires 3 and 5.In such a configuration, it is possible to reduce distortion of the tape member 8 at a portion in contact with the twisted-pair wires 3 and 5 and it is easy to form the composite cable 1 having a circular cross sectional shape.", "If the winding pitch P4 of the tape member 8 is smaller than the twist pitches P1 and P2 of the twisted-pair wires 3 and 5, the tape member 8 with the small winding pitch P4 stretches and contracts in the longitudinal direction when bending the composite cable 1 and is less likely to receive a load caused by the bending, and the load caused by the bending is concentrated on the twisted-pair wires 3 and 5 which have the large twist pitches P1 and P2 and are less likely to stretch and contract.", "When the winding pitch P4 of the tape member 8 is not less than the twist pitches P1 and P2 of the twisted-pair wires 3 and 5, it is possible to partially distribute the load caused by the bending to the tape member 8 such that the load caused by the bending is prevented from being concentrated on the twisted-pair wires 3 and 5, thereby improving flex resistance.", "In addition, since the twist direction of the assembled article 7 is different from the winding direction of the tape member 8, the twist pitch P3 of the assembled article 7 is less likely to change when winding the tape member 8 and it is thereby possible to stabilize the twist pitch P3 of the assembled article 7.Furthermore, by differing the twist direction of the assembled article 7 from the winding direction of the tape member 8, the tape member 8 is prevented from entering gaps between the twisted-pair wires 3, 5 and the third electric wires 6 and it is thereby possible to form the composite cable 1 having a cross sectional shape closer to a circle.", "This results in improving the outer appearance of the composite cable 1 and also allows the sheath 9 to be easily stripped and removed.", "Since the kink is reduced in the composite cable 1 as described above, the sheath 9 is stripped and removed more easily.", "Furthermore, by differing the twist direction of the assembled article 7 from the winding direction of the tape member 8, a direction likely to cause buckling of the assembled article 7 can be different from a direction likely to cause buckling of the tape member 8.Therefore, it is possible to realize the composite cable 1 which is less likely to buckle even when, e.g., twist and bend are simultaneously applied to the composite cable 1.Description of Composite Harness Using the Composite Cable 1 FIG.", "3 is a schematic configuration diagram illustrating a composite harness in the present embodiment.", "As shown in FIG.", "3, a composite harness 11 is composed of the composite cable 1 in the present embodiment and a connector attached to at least one of end portions of the first electric wires 2, of the second electric wires 4 and of the third electric wires 6.In FIG.", "3, an end portion on the wheel 102 side is shown on the left side and an end portion on the vehicle body 105 side (the junction box 106 side) is shown on the right side.", "In the following description, an end of the composite harness 11 on the wheel 102 side is referred to as “one end” and another end on the vehicle body 105 side (the junction box 106 side) is referred to as “other end”.", "The ABS sensor 104a formed by molding a resin so as to cover an end portion of the first electric wires 2 is attached to one end of the pair of first electric wires 2 (the first twisted-pair wire 3), and a vehicle body-side ABS connector 13 for connection to the wire group 107 inside the junction box 106 is attached to the other end of the pair of first electric wires 2 (the first twisted-pair wire 3).", "An air pressure sensor connector 14a for connection to the air pressure sensor 108 is attached to one end of the pair of second electric wires 4 (the second twisted-pair wire 5), and a vehicle body-side air pressure sensor connector 14b for connection to the wire group 107 inside the junction box 106 is attached to the other end of the pair of second electric wires 4 (the second twisted-pair wire 5).", "A wheel-side power connector 12a for connection to the EPB motor 101a is attached to one end of the pair of third electric wires 6, and a vehicle body-side power connector 12b for connection to the wire group 107 inside the junction box 106 is attached to the other end of the pair of third electric wires 6.Although the separate connectors are provided on the first electric wires 2 (the first twisted-pair wire 3), the second electric wires 4 (the second twisted-pair wire 5) and the third electric wires 6 in this example, one dedicated connector may be provided such that the electric wires 2, 4 and 6 are connected all together.", "Functions and Effects of the Embodiment As described above, the composite cable 1 in the present embodiment is provided with the tape member 8 spirally wound around the assembled article 7, and is configured such that the two twisted-pair wires 3 and 5 have the same twist direction, the twist direction of the two twisted-pair wires 3 and 5 is different from the twist direction of the assembled article 7, and the twist direction of the assembled article 7 is different from the winding direction of the tape member 8.Providing the tape member 8 can reduce friction between the electric wires 2, 4, 6 and the sheath 9 without using a lubricant such as talc powder, and thus reduces stress applied to the electric wires 2, 4 and 6 when being bent, and it is thereby possible to improve flex resistance.", "That is, in the present embodiment, it is possible to prevent deterioration of working environment during cable termination the cable while maintaining flex resistance.", "In addition, by differing the twist direction of the twisted-pair wires 3 and 5 from the twist direction of the assembled article 7 and also differing the twist direction of the assembled article 7 from the winding direction of the tape member 8, the kink due to the twisting or the winding of the tape member 8 can be reduced and it is also possible to stabilize the twist pitches P1 to P3 of the twisted-pair wires 3 and 5 and the assembled article 7.As a result, it is possible to reduce variation in bending properties, and also, flexibility in the longitudinal direction is stabilized and it is thereby possible to realize the composite cable 1 which is easy to route.", "Furthermore, since it is possible to form the composite cable 1 having a cross sectional shape closer to a circle, it is easy to strip the sheath 9.Summary of the Embodiments Technical ideas understood from the embodiment will be described below citing the reference numerals, etc., used for the embodiment.", "However, each reference numeral, etc., described below is not intended to limit the constituent elements in the claims to the members, etc., specifically described in the embodiment.", "[1] A composite cable (1), comprising: a first twisted-pair wire (3) formed by twisting a pair of first electric wires (2), each first electric wire (2) comprising a first center conductor (21) and a first insulation (22) covering the first center conductor (21); a second twisted-pair wire (5) formed by twisting a pair of second electric wires (4), each second electric wire (4) comprising a second center conductor (41) and a second insulation (42) covering the second center conductor (41); a pair of third electric wires (3) arranged between the first twisted-pair wire (3) and the second twisted-pair wire (5) in a circumferential direction, each third electric wire (3) having a larger outer diameter than the first electric wire (2) and the second twisted-pair wire (4) and comprising a third center conductor (61) with a larger cross-sectional area than the first center conductor (21) and the second center conductor (41) and a third insulation (62) covering the third center conductor (61); and a tape member (8) spirally wound around an assembled article (7) that is formed by twisting the first twisted-pair wire (3), the second twisted-pair wire (5) and the pair of third electric wires (6) together, wherein the two twisted-pair wires (3, 5) have the same twist direction, the twist direction of the two twisted-pair wires (3, 5) is different from a twist direction of the assembled article (7), and the twist direction of the assembled article (7) is different from a winding direction of the tape member (8).", "[2] The composite cable (1) defined by [1], wherein a twist pitch of the two twisted-pair wires (3, 5) is smaller than a twist pitch of the assembled article (7), and a winding pitch of the tape member (8) is smaller than the twist pitch of the assembled article (7) and is not less than the twist pitches of the two twisted-pair wires (3, 5).", "[3] The composite cable (1) defined by [1] or [2], wherein the tape member (8) is configured such that a surface in contact with the assembled article (7) comprises a non-woven fabric, a paper or a resin layer.", "[4] The composite cable (1) defined by any one of [1] to [3], wherein the third electric wire (6) comprises a power line for supplying a drive current to a motor (101a) for an electric parking brake (101) mounted on a wheel (102) of a vehicle (100).", "[5] The composite cable (1) defined by any one of [1] to [4], wherein at least one of the two twisted-pair wires (3, 5) comprises a signal line for a sensor mounted on a wheel (102) of a vehicle (100).", "[6] The composite cable (1) defined by any one of [1] to [5], wherein the assembled article (7) comprises a plurality of thread-shaped fillers (10) arranged between the first twisted-pair wire (3)/the second twisted-pair wire (5)/the pair of third electric wires (6) and the tape member (8), the plurality of fillers (10) are twisted together with the first twisted-pair wire (3), the second twisted-pair wire (4) and the pair of third electric wires (6), and a twist direction of the plurality of fillers (10) is the same as the twist direction of the assembled article (7) and is different from the winding direction of the tape member (8).", "[7] A composite harness (11), comprising: the composite cable (1) defined by any one of [1] to [6]; and a connector attached to at least one of end portions of the first electric wires (2), of the second electric wires (3) and of the third electric wires (6).", "Although the embodiment of the invention has been described, the invention according to claims is not to be limited to the embodiment described above.", "Further, please note that all combinations of the features described in the embodiment are not necessary to solve the problem of the invention.", "The invention can be appropriately modified and implemented without departing from the gist thereof." ] ]
Patent_15874370
[ [ "RANKING COMBINATIONS OF MUTANTS, TEST CASES AND RANDOM SEEDS IN MUTATION TESTING", "A method and apparatus for ranking combinations of mutants, test cases and random seeds in mutation testing, comprising obtaining, based on a signal of a test case target, logic gates related to the signal of the test case target and mutants on the related logic gates, for a compiled integrated circuit under test; calculating distances between the mutants and the signal of the test case target; performing a circuit simulation on the compiled integrated circuit under test to obtain activation cycle numbers corresponding to combinations of the mutants, test cases and random seeds; obtaining activation cycle number variances corresponding to combinations of the mutants and the test cases; and ranking the combinations of the mutants, the test cases and the random seeds based on the distances, the activation cycle numbers and the activation cycle number variances.", "The invention can reduce the probability that the mutation simulation selects equivalent mutants." ], [ "1.A method for ranking combinations of mutants, test cases and random seeds in mutation testing, comprising: obtaining, using at least one program module of the computing system comprising a processing unit and based on a signal of a test case target, logic gates related to the signal of the test case target and mutants on the related logic gates, for a compiled integrated circuit under test; ranking, using the at least one program module of the computing system, combinations of the mutants, test cases and random seeds based on distances, activation cycle numbers and activation cycle number variances, which reduces a probability of selecting equivalent mutants related to mutants generated for multiple logical gates, the test cases, and the random seeds used in a test simulation; selecting part of the combinations of the mutants, the test cases and the random seeds which are reduced based on ranking of the combinations of the mutants, the test cases and the random seeds; and performing a mutation simulation on the integrated circuit, which is compiled, under test using the selected combinations of the mutants, the test cases and the random seeds.", "2.The method according to claim 1, further comprising calculating, using the at least one program module of the computing system, the distances which are between the mutants and the signal of the test case target; 3.The method according to claim 2, wherein the calculating distances between the mutants and the signal of the test case target uses one of the following: according to the control data flow graph, taking a number of logic gates separated between the related logic gate and the signal of the test case target as the distance between the mutant on the related logic gate and the signal of the test case target; according to the control data flow graph, taking a number of registers separated between the related logic gate and the signal of the test case target as the distance between the mutant on the related logic gate and the signal of the test case target.", "4.The method according to claim 1, wherein the activation cycle numbers are obtained by performing a circuit simulation on the compiled integrated circuit under test, the obtained activation cycle numbers corresponding to combinations of the mutants, test cases and random seeds.", "5.The method according to claim 1, wherein the obtaining logic gates related to the signal of the test case target for a compiled integrated circuit under test comprises: generating a control data flow graph for the compiled integrated circuit under test; using a graph searching algorithm for the generated control data flow graph based on the signal of the test case target to determine the logic gates related to the signal of the test case target in the control data flow graph.", "6.The method according to claim 1, wherein the obtaining mutants on the related logic gates uses one of the following: generating mutants for all logic gates of the compiled integrated circuit under test, and in response to having determined the related logic gates, obtaining the mutants on the related logic gates; or in response to having determined the related logic gates, generating mutants only for the related logic gates.", "7.The method according to claim 1, further comprising performing a circuit simulation on the compiled integrated circuit under test to obtain the activation cycle numbers corresponding to combinations of the mutants, test cases and random seeds, comprising: for each test case, performing the following step: performing the circuit simulation for a predetermined number of times on the compiled integrated circuit under test, wherein in each time of the circuit simulation, one random seed corresponding to the circuit simulation of this time and the activation cycle number for each of the mutants in the test case are obtained.", "8.The method according to claim 1, wherein ranking criteria for ranking the combinations of the mutants, the test cases and the random seeds based on the distances which are between the mutants and the signal of the test case target, the activation cycle numbers which correspond to the combinations of the mutants, the test cases and the random seeds, and activation cycle number variances which correspond to the combinations of the mutants and the test cases, comprises: the smaller the distance between a mutant and the signal of the test case target is, the higher the ranking priority for the combination of the mutant, a test case and a random seed is; the bigger the activation cycle number corresponding to the combination of a mutant, a test case and a random seed is, the higher the ranking priority for the combination of the mutant, the test cases and the random seed is; the bigger the activation cycle number variance corresponding to the combination of a mutant and a test case is, the higher the ranking priority for the combination of the mutant, the test case and a random seed is.", "9.The method according to claim 8, wherein the ranking priority for the combination of a mutant, a test case and a random seed is calculated using the following formula: P m , t , s = F s × 1 d + F d × v c total + F D × D c total where Pm,t,s is the ranking priority corresponding to the combination of the mutant, the test case and the random seed; Fs is a static distance adjusting factor which is a number between 0 and 1; Fd is a mutant activation cycle number adjusting factor which is a number between 0 and 1; FD is a mutant activation cycle number variance adjusting factor which is a number between 0 and 1; d is the distance between the mutant and the signal of the test case target; V is the mutant activation cycle number corresponding to the combination of the mutant, the test case and the random seed; D is the activation cycle number variance corresponding to the combinations of the mutant and the test case; ctotal is a total number of simulation cycles.", "10.An apparatus comprising a processor of a computing system for ranking combinations of mutants, test cases and random seeds in mutation testing, comprising: an activation cycle number obtaining module configured to perform a circuit simulation on a compiled integrated circuit under test to obtain activation cycle numbers corresponding to combinations of the mutants, test cases and random seeds; an activation cycle number variance obtaining module configured to obtain activation cycle number variances corresponding to combinations of the mutants and the test cases; a ranking module configured to rank the combinations of the mutants, the test cases and the random seeds based on distances, activation cycle numbers and activation cycle number variances; and a combination selecting module configured to select part of the combinations of the mutants, the test cases and the random seeds based on the ranking of the combinations of the mutants, the test cases and the random seeds and testing requirements, thereby reducing an invalid test simulation.", "11.The apparatus according to claim 10, wherein the ranking reduces a probability that the combination selecting module will select equivalent mutants related to the mutants generated for multiple logical gates, the test case, and the random seed used in a test simulation, and the related logic gate and mutant thereon obtaining module comprises a control data flow graph generating module configured to generate a control data flow graph for the compiled integrated circuit under test with a reduced number of the related logic gates.", "12.The apparatus according to claim 11, further comprising a related logic gate and mutant thereon obtaining module configured to obtain, based on a signal of a test case target, logic gates related to the signal of the test case target and mutants on the related logic gates, for a compiled integrated circuit under test, wherein the related logic gate and mutant thereon obtaining module comprises: a related logic gate obtaining module configured to use a graph searching algorithm for the generated control data flow graph based on the signal of the test case target to determine the logic gates related to the signal of the test case target in the control data flow graph.", "13.The apparatus according to claim 12, wherein the related logic gate and mutant thereon obtaining module obtains the mutants on the related logic gates by using one of the following: generating mutants for all logic gates of the compiled integrated circuit under test, and in response to having determined the related logic gates, obtaining the mutants on the related logic gates; or in response to having determined the related logic gates, generating mutants only for the related logic gates.", "14.The apparatus according to claim 10, wherein the activation cycle number obtaining module is further configured to perform the following step for each test case: performing the circuit simulation for a predetermined number of times on the compiled integrated circuit under test, wherein in each time of the circuit simulation, one random seed corresponding to the circuit simulation of this time and the activation cycle number for each of the mutants in the test case are obtained.", "15.The apparatus according to claim 10, wherein ranking criteria used by the ranking module comprises: the smaller the distance between a mutant and the signal of the test case target is, the higher the ranking priority for the combination of the mutant, a test case and a random seed is; the bigger the activation cycle number corresponding to a combination of a mutant, a test case and a random seed is, the higher the ranking priority for the combination of the mutant, the test case and the random seed is; the bigger the activation cycle number variance corresponding to a combination of a mutant and a test case is, the higher the ranking priority for the combination of the mutant, the test case and a random seed is.", "16.The apparatus according to claim 15, wherein the ranking module calculates the ranking priority for a combination of a mutant, a test case and a random seed using the following formula: P m , t , s = F s × 1 d + F d × v c total + F D × D c total where Pm,t,s is the ranking priority corresponding to the combination of the mutant, the test case and the random seed; Fs is a static distance adjusting factor which is a number between 0 and 1; Fd is a mutant activation cycle number adjusting factor which is a number between 0 and 1; FD is a mutant activation cycle number variance adjusting factor which is a number between 0 and 1; d is the distance between the mutant and the signal of the test case target; v is the mutant activation cycle number corresponding to the combination of the mutant, the test case and the random seed; D is the activation cycle number variance corresponding to the combination of the mutant and the test case; ctotal is a total number of simulation cycles.", "17.The apparatus according to claim 16, further comprising: a mutation simulating module configured to perform a mutation simulation on the compiled integrated circuit under test using the selected combinations of the mutants, the test cases and the random seeds.", "18.The apparatus according to claim 17, further comprising an evaluating module configured to evaluate, using the following formula, whether the selected combinations of the mutants, the test cases and the random seeds are suitable: Q p = Σ   activation   cycle   number   for   test   case   target related   to   selected   combinations number   of   test   case   targets   related   to   selected   combinations × average   of   activation   cycle   number   of   selected   combinations where the bigger the Qp is, the more suitable the selected combinations are.", "19.The apparatus according to claim 18, further comprising a re-ranking module configured to re-rank the combinations of the mutants, the test cases and the random seeds in response that the Q P does not meet a set threshold." ], [ "<SOH> BACKGROUND <EOH>Functional verification is a method for ensuring the functional correctness of an integrated circuit, and occupies an important position in an integrated circuit design flow.", "A high-quality functional verification platform is a premise for ensuring the whole flow credible and reliable, and further ensuring the functional correctness of the integrated circuit.", "Mutation testing may evaluate the quality of the functional verification platform so that a verification engineer can quantitatively give evaluation criteria.", "The basic steps of the current mutation testing are divided into three parts: 1) randomly selecting at least one mutant after generating mutants for multiple logic gates of a compiled integrated circuit under test.", "Here, the integrated circuit under test may be described with a Hardware Description Language (HDL), and may be compiled with tools such as NCVerilog, NCVHDL, Portals, etc.", "Here, the mutation refers to changing the function of a certain logic gate in the integrated circuit under test, for example, changing the function of an “AND” logic gate into an “OR/XOR/XNOR” logic gate.", "In a word, it is called a mutant as long as its function is different from the “AND.” Generating mutants for multiple logic gates of the compiled integrated circuit under test is the prior art, and it may be implemented using the existing methods for changing functions of logic gates and changing the number of inputs and outputs of the logic gates.", "2) Performing a mutation testing simulation for the integrated circuit under test.", "The mutation testing simulation is very similar to an ordinary circuit simulation, and the only difference is enabling the mutation during the simulation.", "During each mutation testing simulation, only one mutant and one test case can be used.", "Here, the test case refers to, according to a test target, adding a series of inputs to the integrated circuit under test, and observing by a checker whether outputs of the integrated circuit under test conform to the expected states.", "Each group of input signals plus a corresponding checking policy is called one test case.", "For example, if it is to test the function of an “AND” logic gate having two input signals, it is necessary to add different values, i.e.", "<1, 1>; <1, 0>; <0, 1>; <0, 0> to the two input signals of the “AND” logic gate; each group of input values has a desired output check, for example, when the input is <1, 1>, the desired output is 1; when the input is <1, 0>, the desired output is 0, and so on.", "Here, each group of input values is the test case for the “AND” logic gate.", "3) Giving quantitative evaluation criteria for the quality of the functional verification platform by synthesizing a series of logical function changes and their observation results.", "That is, steps 1 and 2 are executed recurrently to obtain the mutation testing results of a series of logic gates.", "Based on the obtained results, it is observed whether the functional verification platform can normally check a change in the logical function of the integrated circuit under test.", "For example, in the above “AND” gate case, if the input signal is <0, 1>, the output result of the “AND” gate should be 0, and the functional verification platform should also expect that the output result is 0.If the function of the “AND” gate is changed into “OR,” then the output is now changed into 1, and at this time it is necessary to observe whether the functional verification platform can normally report an error because the functional verification platform deems that the logical function is still the “AND.” If the functional verification platform does not report an error, it means that it does not normally detect the change of the logical function, and then there must be something wrong with the checker.", "When performing the mutation testing, if it is to accurately observe whether the functional verification platform can detect changes of all logical functions, it is better to test all mutants against all test cases.", "Supposing that there exist 1 million mutants, using 50 test cases, 4 random seeds, and each simulation lasting 1 hour, then it needs to perform the mutation testing simulation for 200 million hours.", "When randomly selecting a mutant, if in a certain simulation, since the testing stimulus generated by the current test case cannot activate the mutant, the result of this simulation is consistent with that without mutation, and this simulation becomes an invalid simulation, and the mutant is called an Equivalent Mutant.", "The cause of the equivalent mutant is that the current test case does not add to the mutant with an input signal that may cause the function of the mutant to change.", "Again, taking the above “AND” logic gate as an example, if the “AND” is mutated to “OR,” while there are only two test cases, one is for the input signal <1, 1> and the other is for the input signal <0, 0>, then the outputs of the two input signals are the same for the “AND” and “OR”, and the functions do not change, and thus the mutant is not activated.", "In order to improve efficiency for the quality evaluation of the functional verification platform, it is necessary to reduce equivalent mutants." ], [ "<SOH> SUMMARY <EOH>The equivalent mutant is related to the mutant per se, the test case, and even the random seed used in the simulation.", "In the prior art, since the mutants generated for multiple logical gates are selected randomly in the test, the probability that the selected mutant may be the equivalent mutant is large, thereby causing an invalid simulation.", "The method and system provided by the prevent invention can rank the combinations of mutants, test cases and random seeds, and thereby can reduce the probability for selecting the equivalent mutant, and thus can reduce the invalid simulation and improve the efficiency for quality evaluation of the functional verification platform within limited testing time.", "According to one aspect of the present invention, there is provided a method for ranking combinations of mutants, test cases and random seeds in mutation testing, comprising: obtaining, based on a signal of a test case target, logic gates related to the signal of the test case target and mutants on the related logic gates for a compiled integrated circuit under test; calculating distances between the mutants and the signal of the test case target; performing a circuit simulation on the compiled integrated circuit under test to obtain activation cycle numbers corresponding to combinations of the mutants, test cases and random seeds; obtaining activation cycle number variances corresponding to combinations of the mutants and the test cases; and ranking the combinations of the mutants, the test cases and the random seeds based on the distances, the activation cycle numbers and the activation cycle number variances.", "According to another aspect of the present invention, there is provided an apparatus for ranking combinations of mutants, test cases and random seeds in mutation testing, comprising: a related logic gate and mutant thereon obtaining module configured to obtain, based on a signal of a test case target, logic gates related to the signal of the test case target and mutants on the related logic gates, for a compiled integrated circuit under test; a distance calculating module configured to calculate distances between the mutants and the signal of the test case target; an activation cycle number obtaining module configured to perform a circuit simulation on the compiled integrated circuit under test to obtain activation cycle numbers corresponding to combinations of the mutants, test cases and random seeds; an activation cycle number variance obtaining module configured to obtain activation cycle number variances corresponding to combinations of the mutants and the test cases; and a ranking module configured to rank the combinations of the mutants, the test cases and the random seeds based on the distances, the activation cycle numbers and the activation cycle number variances." ], [ "TECHNICAL FIELD The present invention relates to quality evaluation of an integrated circuit testing platform, and more specifically, to a method and apparatus for ranking combinations of mutants, test cases and random seeds in mutation testing.", "BACKGROUND Functional verification is a method for ensuring the functional correctness of an integrated circuit, and occupies an important position in an integrated circuit design flow.", "A high-quality functional verification platform is a premise for ensuring the whole flow credible and reliable, and further ensuring the functional correctness of the integrated circuit.", "Mutation testing may evaluate the quality of the functional verification platform so that a verification engineer can quantitatively give evaluation criteria.", "The basic steps of the current mutation testing are divided into three parts: 1) randomly selecting at least one mutant after generating mutants for multiple logic gates of a compiled integrated circuit under test.", "Here, the integrated circuit under test may be described with a Hardware Description Language (HDL), and may be compiled with tools such as NCVerilog, NCVHDL, Portals, etc.", "Here, the mutation refers to changing the function of a certain logic gate in the integrated circuit under test, for example, changing the function of an “AND” logic gate into an “OR/XOR/XNOR” logic gate.", "In a word, it is called a mutant as long as its function is different from the “AND.” Generating mutants for multiple logic gates of the compiled integrated circuit under test is the prior art, and it may be implemented using the existing methods for changing functions of logic gates and changing the number of inputs and outputs of the logic gates.", "2) Performing a mutation testing simulation for the integrated circuit under test.", "The mutation testing simulation is very similar to an ordinary circuit simulation, and the only difference is enabling the mutation during the simulation.", "During each mutation testing simulation, only one mutant and one test case can be used.", "Here, the test case refers to, according to a test target, adding a series of inputs to the integrated circuit under test, and observing by a checker whether outputs of the integrated circuit under test conform to the expected states.", "Each group of input signals plus a corresponding checking policy is called one test case.", "For example, if it is to test the function of an “AND” logic gate having two input signals, it is necessary to add different values, i.e.", "<1, 1>; <1, 0>; <0, 1>; <0, 0> to the two input signals of the “AND” logic gate; each group of input values has a desired output check, for example, when the input is <1, 1>, the desired output is 1; when the input is <1, 0>, the desired output is 0, and so on.", "Here, each group of input values is the test case for the “AND” logic gate.", "3) Giving quantitative evaluation criteria for the quality of the functional verification platform by synthesizing a series of logical function changes and their observation results.", "That is, steps 1 and 2 are executed recurrently to obtain the mutation testing results of a series of logic gates.", "Based on the obtained results, it is observed whether the functional verification platform can normally check a change in the logical function of the integrated circuit under test.", "For example, in the above “AND” gate case, if the input signal is <0, 1>, the output result of the “AND” gate should be 0, and the functional verification platform should also expect that the output result is 0.If the function of the “AND” gate is changed into “OR,” then the output is now changed into 1, and at this time it is necessary to observe whether the functional verification platform can normally report an error because the functional verification platform deems that the logical function is still the “AND.” If the functional verification platform does not report an error, it means that it does not normally detect the change of the logical function, and then there must be something wrong with the checker.", "When performing the mutation testing, if it is to accurately observe whether the functional verification platform can detect changes of all logical functions, it is better to test all mutants against all test cases.", "Supposing that there exist 1 million mutants, using 50 test cases, 4 random seeds, and each simulation lasting 1 hour, then it needs to perform the mutation testing simulation for 200 million hours.", "When randomly selecting a mutant, if in a certain simulation, since the testing stimulus generated by the current test case cannot activate the mutant, the result of this simulation is consistent with that without mutation, and this simulation becomes an invalid simulation, and the mutant is called an Equivalent Mutant.", "The cause of the equivalent mutant is that the current test case does not add to the mutant with an input signal that may cause the function of the mutant to change.", "Again, taking the above “AND” logic gate as an example, if the “AND” is mutated to “OR,” while there are only two test cases, one is for the input signal <1, 1> and the other is for the input signal <0, 0>, then the outputs of the two input signals are the same for the “AND” and “OR”, and the functions do not change, and thus the mutant is not activated.", "In order to improve efficiency for the quality evaluation of the functional verification platform, it is necessary to reduce equivalent mutants.", "SUMMARY The equivalent mutant is related to the mutant per se, the test case, and even the random seed used in the simulation.", "In the prior art, since the mutants generated for multiple logical gates are selected randomly in the test, the probability that the selected mutant may be the equivalent mutant is large, thereby causing an invalid simulation.", "The method and system provided by the prevent invention can rank the combinations of mutants, test cases and random seeds, and thereby can reduce the probability for selecting the equivalent mutant, and thus can reduce the invalid simulation and improve the efficiency for quality evaluation of the functional verification platform within limited testing time.", "According to one aspect of the present invention, there is provided a method for ranking combinations of mutants, test cases and random seeds in mutation testing, comprising: obtaining, based on a signal of a test case target, logic gates related to the signal of the test case target and mutants on the related logic gates for a compiled integrated circuit under test; calculating distances between the mutants and the signal of the test case target; performing a circuit simulation on the compiled integrated circuit under test to obtain activation cycle numbers corresponding to combinations of the mutants, test cases and random seeds; obtaining activation cycle number variances corresponding to combinations of the mutants and the test cases; and ranking the combinations of the mutants, the test cases and the random seeds based on the distances, the activation cycle numbers and the activation cycle number variances.", "According to another aspect of the present invention, there is provided an apparatus for ranking combinations of mutants, test cases and random seeds in mutation testing, comprising: a related logic gate and mutant thereon obtaining module configured to obtain, based on a signal of a test case target, logic gates related to the signal of the test case target and mutants on the related logic gates, for a compiled integrated circuit under test; a distance calculating module configured to calculate distances between the mutants and the signal of the test case target; an activation cycle number obtaining module configured to perform a circuit simulation on the compiled integrated circuit under test to obtain activation cycle numbers corresponding to combinations of the mutants, test cases and random seeds; an activation cycle number variance obtaining module configured to obtain activation cycle number variances corresponding to combinations of the mutants and the test cases; and a ranking module configured to rank the combinations of the mutants, the test cases and the random seeds based on the distances, the activation cycle numbers and the activation cycle number variances.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS Through the more detailed description of exemplary embodiments of the present disclosure in the accompanying drawings, the above and other objects, features and advantages of the present disclosure will become more apparent, wherein the same reference generally refers to the same components in the exemplary embodiments of the present disclosure.", "FIG.", "1 shows a block diagram of an exemplary computer system/server 12 which is applicable to implement embodiments of the present invention; FIG.", "2 shows a flow of a method for ranking mutants in mutation testing according to one embodiment of the present invention; FIG.", "3 is a schematic diagram of different first regions determined based on signals of three different test case targets; FIG.", "4 shows specific implementing steps of obtaining related logic gates in Step S201; FIG.", "5 exemplarily shows a schematic diagram of a control data flow graph generated for a part of an integrated circuit; FIG.", "6 shows all logic gates related to output signal x in a case that the signal of a given test case target is the output signal x in the control data flow graph as shown in FIG.", "5; and FIG.", "7 shows a structural diagram of an apparatus for ranking combinations of mutants, test cases and random seeds in mutation testing.", "DETAILED DESCRIPTION Some preferable embodiments will be described in more detail with reference to the accompanying drawings, in which the preferable embodiments of the present disclosure have been illustrated.", "However, the present disclosure can be implemented in various manners, and thus should not be construed to be limited to the embodiments disclosed herein.", "On the contrary, those embodiments are provided for the thorough and complete understanding of the present disclosure, and completely conveying the scope of the present disclosure to those skilled in the art.", "Referring now to FIG.", "1, in which a block diagram of an exemplary computer system/server 12 which is applicable to implement the embodiments of the present invention is shown.", "Computer system/server 12 shown in FIG.", "1 is only illustrative and is not intended to suggest any limitation as to the scope of use or functionality of embodiments of the invention described herein.", "As shown in FIG.", "1, computer system/server 12 is represented in the form of a general-purpose computing device.", "The components of computer system/server 12 may include, but are not limited to, one or more processors or processing units 16, a system memory 28, and a bus 18 that couples various system components, including system memory 28 and processing unit 16.Bus 18 represents one or more of several types of bus structures, including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, and a processor or local bus using any of a variety of bus architectures.", "By way of example, and without limitation, such architectures include Industry Standard Architecture (ISA) bus, Micro Channel Architecture (MAC) bus, Enhanced ISA (EISA) bus, Video Electronics Standards Association (VESA) local bus, and Peripheral Component Interconnect (PCI) bus.", "Computer system/server 12 typically includes a variety of computer system readable media.", "Such media may be any available media that is accessible by computer system/server 12, and it includes both volatile and non-volatile media, removable and non-removable media.", "System memory 28 can include computer system readable media in the form of volatile memory, such as random access memory (RAM) 30 and/or cache memory 32.Computer system/server 12 may further include other removable/non-removable, volatile/non-volatile computer system storage media.", "By way of example only, storage system 34 can be provided for reading from and writing to a non-removable, non-volatile magnetic media (not shown in FIG.", "1 and typically called a “hard drive”).", "Although not shown in FIG.", "1, a magnetic disk drive for reading from and writing to a removable, non-volatile magnetic disk (e.g., a “floppy disk”), and an optical disk drive for reading from or writing to a removable, non-volatile optical disk such as a CD-ROM, DVD-ROM or other optical media can be provided.", "In such instances, each drive can be connected to bus 18 by one or more data media interfaces.", "As will be further depicted and described below, memory 28 may include at least one program product having a set (e.g., at least one) of program modules that are configured to carry out the functions of embodiments of the invention.", "Program/utility 40, having a set (at least one) of program modules 42, may be stored in memory 28 by way of example.", "Such program modules 42 include, but are not limited to an operating system, one or more application programs, other program modules, and program data.", "Each of the operating system, one or more application programs, other program modules, and program data or some combination thereof, may include an implementation of a networking environment.", "Program modules 42 generally carry out the functions and/or methodologies of embodiments of the invention as described herein.", "Computer system/server 12 may also communicate with one or more external devices 14 such as a keyboard, a pointing device, a display 24, etc.", "; one or more devices that enable a user to interact with computer system/server 12; and/or any devices (e.g., network card, modem, etc.)", "that enable computer system/server 12 to communicate with one or more other computing devices.", "Such communication can occur via Input/output (I/O) interfaces 22.Still yet, computer system/server 12 can communicate with one or more networks such as a local area network (LAN), a general wide area network (WAN), and/or a public network (e.g., the Internet) via network adapter 20.As depicted, network adapter 20 communicates with the other components of computer system/server 12 via bus 18.It should be understood that although not shown, other hardware and/or software components could be used in conjunction with computer system/server 12.Examples, include, but are not limited to: microcode, device drivers, redundant processing units, external disk drive arrays, RAID systems, tape drives, and data archival storage systems, etc.", "FIG.", "2 shows a flow of a method for ranking mutants in mutation testing according to one embodiment of the present invention.", "According to FIG.", "2, in step S201, based on a signal of a test case target, logic gates related to the signal of the test case target and mutants on the related logic gates are obtained for a compiled integrated circuit under test; in step S202, distances between the mutants and the signal of the test case target are calculated; in step S203, a circuit simulation is performed on the compiled integrated circuit under test to obtain activation cycle numbers corresponding to combinations of respective mutants, test cases and random seeds; in step S204, activation cycle number variances corresponding to combinations of the mutants and the test cases are obtained; in step S205, the combinations of the mutants, test cases and random seeds are ranked based on the distances between the mutants and the signal of the test case target, the activation cycle numbers corresponding to the combinations of the mutants, test cases and random seeds, and the activation cycle number variances corresponding to the combinations of the mutants and test cases.", "After the ranking, it is possible to select a part of the combinations for the mutation testing simulation, based on the ranked combinations of the mutants, test cases and random seeds.", "In step S201, based on the signal of the test case target, logic gates related to the signal of the test case target and mutants on the related logic gates are obtained for the compiled integrated circuit under test.", "A region for combining these logic gates is called a first region in the present invention.", "The first region is a set of all logic gates logically related to the test case.", "Wherein, the test target is the content that will be tested via the test case.", "For example, in the above “AND” logic gate example, the target of the test case is to test whether the output of the “AND” logic gate meets the behavior of “AND”.", "In some cases, the signal of the test case target is the output of the logic gate, while in some other cases, the signal of the test case target is an intermediate signal of the logic gate, etc.", "When determining the first region, the signal of the test case target may comprise the following three different signals, i.e., a signal at input and output pins of a specific module to which the test case is directed, a signal of a specific register bit to which the test case is directed, and a signal of a specific state of an internal state machine to which the test case is directed.", "FIG.", "3 is a schematic diagram of different first regions determined based on signals of three different test case targets.", "The first regions determined by using signals of different test case targets may be different.", "FIG.", "4 shows particular implementing steps of obtaining the related logic gates in step S201.According to FIG.", "4, in step S401, a control data flow graph (CDFG) is generated for the compiled integrated circuit under test.", "This step is the customary technical means for those skilled in the art and thus the particular implementing method therefor is not described herein.", "FIG.", "5 exemplarily shows a schematic diagram of a control data flow graph generated for a part of an integrated circuit.", "In step S402, a graph searching algorithm is used for the generated control data flow graph based on the signal of the test case target to determine the logic gates related to the signal of the test case target in the control data flow graph.", "The graph searching algorithm is also the customary technical means for those skilled in the art, which is not detailed herein.", "FIG.", "6 shows all logic gates related to output signal x in a case that the signal of a given test case target is the output signal x in the control data flow graph as shown in FIG.", "5, wherein all related logic gates are shown as grey circles.", "Apparently, step S201 may reduce the number of the logic gates to a certain range.", "For example, the compiled integrated circuit under test has 100,000 logic gates in total, and 20,000 related logic gates can be determined after the analysis.", "Regarding the obtaining of the mutants on the related logic gates, one embodiment may use the prior art to firstly generate mutants for all logical gates of the compiled integrated circuit under test; once the related logic gates have been determined in step S402, the mutants on the related logic gates may be obtained.", "In another embodiment, it is possible to firstly respond to having determined the related logic gates in step S402, and then to generate mutants only for the related logic gates.", "After obtaining the first region, the related logic gates and mutants thereon in step S201, it is possible to calculate distances between the mutants and the signal of the test case target in step S202.In the calculation, it is possible to use, based on the control data flow graph, a number of logic gates between the related logic gate and the signal of the test case target or a number of registers between the related logic gate and the signal of the test case target etc.", "as the distance between the mutant on the related logic gate and the signal of the test case target.", "The distance is one of the parameters for finally calculating the ranking priorities of the combinations of the mutants, test cases and random seeds.", "The nearer the distance is, the bigger the probability that the mutant cause an influence on the signal of the test case target is.", "Thus, the combination of the mutant, a test case and a random seed shall be given a higher priority.", "With reference to the integrated circuit as shown in FIG.", "6, if the number of the separated logic gates is used to calculate the distance between the mutant and the signal of the test case target, then there are two logic gates separated between #0 mutant (MU) and the output signal x of the test case target, and thus the distance is 2.Similarly, the distance between #1 MU and the output signal x of the test case target is 1.Now referring back to FIG.", "2, in the implementing solution of performing the circuit simulation on the compiled integrated circuit under test to obtain the activation cycle numbers corresponding to the combinations of the mutants, test cases and random seeds in step S203, it is possible to perform the following step for each test case: performing the circuit simulation for a predetermined number of times on the compiled integrated circuit under test, wherein in each time of the circuit simulation, one random seed corresponding to the circuit simulation of this time and the activation cycle number for each mutant in the test case are obtained.", "The mutation testing simulation may use tools including NCSIM, VCS, ModelSim, Mesa, etc.", "Table 1 shows a simple example for calculating the ranking priorities of the combinations of the mutants, test cases and random seeds.", "In Table 1, each combination of the mutant, test case and random seed is assigned an identification number, and corresponds to a group of values for the mutant, test case and random seed, that is, a combination.", "Table 1 includes two mutants, i.e.", "#0 mutant and #1 mutant, and two test cases, i.e.", "#0 test case and #1 test case.", "In fact, in one circuit simulation, all generated mutants are injected to corresponding related logic gates, but the mutants are not activated.", "Thus, it is possible to simulate the random seeds of this simulation by a common circuit for one test case, and to obtain the activation cycle number for each mutant in this test case.", "The determined activation cycle number corresponds to a specific random seed.", "Then, for the same test case, multiple circuit simulations are performed to obtain a random seed corresponding to each circuit simulation, and the activation cycle number for each mutant in this test case.", "Here, the multiple simulations plus the first simulation may be regarded as the predetermined times of simulations.", "For example, in Table 1, the predetermined times is 3.Then, for different test cases, the predetermined times of circuit simulations are performed on each test case to obtain a random seed corresponding to each simulation, and the activation cycle number for each mutant in this test case.", "For example, regarding the example as shown in Table 1, in the first circuit simulation, the combinations identified as 0 and 6 are simulated to obtain a random seed 0x52b3487f and two activation cycle numbers; in the second circuit simulation, the combinations identified as 1 and 7 are simulated to obtain a random seed 0x9837abcf and two activation cycle numbers; in the third circuit simulation, the combinations identified as 2 and 8 are simulated to obtain a random seed 0xab48dce9 and two activation cycle numbers; by this way, 6 circuit simulations in total need to be performed to obtain 6 random seeds and 12 activation cycle numbers.", "The random seeds needed in the circuit simulations may be input by a user; if no random seed is input, the simulation platform will automatically generate random seeds.", "A bigger activation cycle number means that the combination of the mutant, test case and random seed more likely influence the output of the integrated circuit under test, and thus shall be given a higher ranking priority.", "For the same combination of the mutant and test case, if the activation cycle number obtained using a different random seed changes greatly, then this combination of the mutant, test case and random seed shall be given a higher ranking priority, because this situation means that, regarding the test cases and mutants, the situation triggered by the random seed is an abnormal situation, and can provide the functional verification platform with a bigger test pressure, and thus shall be given a higher ranking priority.", "The varying situation may be implemented by calculating all activation cycle number variances corresponding to the situations with the same mutant, the same test case and different random seeds in step S204.Calculation of the variance of several values is well-known to those skilled in the art, which is not detailed herein.", "For example, regarding the example of Table 1, 4 variance values may be obtained.", "Ranking the combinations of the mutants, test cases and random seeds based on the distances between the mutants and the signal of the test case target, the activation cycle numbers corresponding to the combinations of the mutants, test cases and random seeds, and the activation cycle number variances corresponding to the combinations of the mutants and test cases in step S205 have been described above, and the ranking criteria for ranking the combinations of the mutants, test cases and random seeds comprises: a higher priority shall be given to the combination with a nearer (smaller) distance; a higher priority shall be given to the combination with a bigger activation cycle number; and a higher priority shall be given to the combination with a bigger activation cycle number variance.", "In a simple implementation, the priority for a mutant may be calculated using the following formula: P m , t , s = F s × 1 d + F d × v c total + F D × D c total where, Pm,t,s is the ranking priority corresponding to a combination of the mutant, a test case and a random seed; Fs is a static distance adjusting factor which is a number between 0 and 1; Fd is a mutant activation cycle number adjusting factor which is a number between 0 and 1; FD is a mutant activation cycle number variance adjusting factor which is a number between 0 and 1; d is the distance between the mutant and the signal of the test case target; v is the mutant activation cycle number corresponding to a combination of a mutant, test case and random seed; D is the activation cycle number variance corresponding to the combination of the mutant and the test case; Ctotal is a total number of simulation cycles.", "Here, F is an adjusting factor respectively for different parts, and allows an engineer to adjust the proportion of different parts based on particular project characteristics.", "There are many methods for calculating the priority of the combination based on the ranking criteria for ranking the combinations of mutants, test cases and random seeds, and the above formula is only one of them.", "Those skilled in the art may design a suitable combination priority calculating method based on the above principle.", "TABLE 1 Mutant Number of Activation Test Number of Mutant Cycle Mutant Case Random Simulation Activation Static Number Identifier Label Label Seed Cycles Cycles Distance Variance Priority 0 0 0 0x52b3487f 1000 999 2 513 2.012 1 0 0 0x9837abcf 1000 1 1.014 2 0 0 0xab48dce9 1000 293 1.306 3 1 1 0x23847287 500000 398475 1 45497 1.888 4 1 1 0x89823abf 520000 342343 1.746 5 1 1 0x87abce45 500500 432432 1.955 6 1 0 0x52b3487f 10000 343 266 1.061 7 1 0 0x9837abcf 10000 123 1.039 8 1 0 0xab48dce9 10000 654 1.092 9 0 1 0x23847287 400000 0 2 197616 0.994 10 0 1 0x89823abf 400000 342343 1.850 11 0 1 0x87abce45 450000 124 0.939 Table 1 gives the ranking priority for each combination calculated using the above formula when the adjusting factors of different parts are all 1.It is possible to rank the combinations based on the values of the priorities.", "In the ranking results, what ranks the highest (#0 identifier) is the combination of the mutant label 0, the test case label 0 and the specific random seed; what ranks the second-highest (#5 identifier) is the combination of the mutant label 1, the test case label 1 and the specific random seed; by that analogy, the ranking results according to the combination identifiers are: 0, 5, 3, 10, 4, 2, 8, 6, 7, 1, 9 and 11.Thus, the mutation testing simulation may be performed according to the ranked combinations.", "For example, if only 5 combinations are selected, then the selected identifiers are: 0, 5, 3, 10 and 4.In one embodiment, part of the combinations of the mutants, test cases and random seeds are selected based on the ranking of the combinations of the mutants, test cases and random seeds and testing requirements; and then the mutation simulation is performed on the compiled integrated circuit under test using the selected combinations of the mutants, test cases and random seeds.", "During the simulation, mutation is enabled.", "If the generated mutant is logically related to a certain output signal, then the output signal becomes the target point of the mutant.", "If the mutant is activated, then the behavior of the target point is expected to change also, that is, also activated.", "Overall, if the ranking of the combinations of the mutants, test cases and random seeds is proper, then after the circuit simulation, it will be observed that the total activation cycle number for the test case target is very close to the total activation cycle number of the mutant.", "With the ratio between them, quality of the current ranking can be quantitatively determined.", "Based on this idea, in one preferred embodiment, the quality of the above combination ranking can be determined by the following formula: Q p = Σ   activation   cycle   number   for   test   case   target related   to   selected   combinations number   of   test   case   targets   related   to   selected   combinations × average   of   activation   cycle   number   of   selected   combinations Where, the selected combinations refer to the combinations of mutants, test cases and random seeds selected for mutation testing after ranking the combinations of the mutants, test cases and random seeds, for example, in Table 1, they refer to the combinations with identifiers 0, 5, 3, 10, 4.Each combination has at least one related test case target, and when there is more than one related test case target, it is necessary to obtain via the control data flow graph the number of signals of all test targets corresponding to the mutant as the number of related test case targets.", "It is common knowledge for those skilled in the art to obtain specifically by the control data flow graph the number of signals of all test targets corresponding to the mutant, which is not detailed herein.", "Assuming that the numbers of the related test case targets corresponding to the combinations 0, 5, 3, 10 and 4 are respectively 1, 2, 3, 4, 5 and 6, then after activating the #0 combination and enabling the mutation, the activation cycle number of each test case target related to the combination corresponding to the test case target may be obtained by performing the mutation simulation using the random seed 0x52b3487f.", "For example, regarding #5 combination, based on the above assumption, there are two test case targets, assuming that the activation cycle numbers of the test case targets related to the combination obtained by the mutation simulation are A and B respectively, then in the numerator of the above formula, a sum of A+B is recorded; likewise, it is similar to the other combinations; thus the numerator has the sum obtained by adding the activation cycle numbers of 1+2+3+4+5+6=21 test case targets related to different combinations.", "In the denominator, the number of the test case targets related to the selected combinations is 21, the activation cycle number of the selected combinations is the average of each number in the column of the mutant activation cycle number of the above 6 combinations in Table 1.In particular, the bigger the Qp is, the more suitable the selected combinations are, that is, the higher the ranking quality is.", "Specifically, those skilled in the art may set a threshold for Qp based on their experience, and only the ranking that corresponds to the combinations corresponding to the Qp that meets the threshold condition can be accepted; otherwise, it is necessary to re-rank.", "Within the same inventive concept, the present invention further discloses an apparatus for ranking combinations of mutants, test cases and random seeds in mutation testing.", "FIG.", "7 shows a structural diagram of an apparatus 700 for ranking combinations of mutants, test cases and random seeds in mutation testing.", "According to FIG.", "7, the apparatus comprises: a related logic gate and mutant thereon obtaining module 701 configured to obtain, based on a signal of a test case target, logic gates related to the signal of the test case target and mutants on the related logic gates for a compiled integrated circuit under test; a distance calculating module 702 configured to calculate distances between the mutants and the signal of the test case target; an activation cycle number obtaining module 703 configured to perform a circuit simulation on the compiled integrated circuit under test to obtain activation cycle numbers corresponding to the combinations of the mutants, test cases and random seeds; an activation cycle number variance obtaining module 704 configured to obtain activation cycle number variances corresponding to combinations of the mutants and the test cases; and a ranking module 705 configured to rank the combinations of the mutants, test cases and random seeds based on the distances between the mutants and the signal of the test case target, the activation cycle numbers corresponding to the combinations of the mutants, test cases and random seeds, and the activation cycle number variances corresponding to the combinations of the mutants and test cases.", "In one embodiment, the related logic gate and mutant thereon obtaining module comprises: a control data flow graph generating module configured to generate a control data flow graph for the compiled integrated circuit under test; and a related logic gate obtaining module configured to use a graph searching algorithm for the generated control data flow graph based on the signal of the test case target to determine the logic gates related to the signal of the test case target in the control data flow graph.", "In one embodiment, the related logic gate and mutant thereon obtaining module obtains the mutants on the related logic gates by one of: (1) generating mutants for all logic gates of the compiled integrated circuit under test, and in response to having determined the related logic gates, obtaining the mutants on the related logic gates; (2) in response to having determined the related logic gates, generating mutants only for the related logic gates.", "In one embodiment, the distance calculating module calculates the distances between the mutants and the signal of the test case target by one of: (1) according to the control data flow graph, taking a number of logic gates separated between the related logic gate and the signal of the test case target as the distance between the mutant on the related logic gate and the signal of the test case target; (2) according to the control data flow graph, taking a number of registers separated between the related logic gate and the signal of the test case target as the distance between the mutant on the related logic gate and the signal of the test case target.", "In one embodiment, the activation cycle number obtaining module is further configured to perform the following steps for each test case: performing a circuit simulation for a predetermined number of times on the compiled integrated circuit under test, wherein in each time of the circuit simulation, one random seed corresponding to the circuit simulation of this time and the activation cycle number for each of the mutants in the test case are obtained.", "In one embodiment, ranking criteria used by the ranking module comprises: (1) the smaller the distance between a mutant and the signal of the test case target is, the higher the ranking priority for the combination of the mutant, a test case and a random seed is; (2) the bigger the activation cycle number corresponding to a combination of a mutant, a test case and a random seed is, the higher the ranking priority for the combination of the mutant, the test case and the random seed is; (3) the bigger the activation cycle number variance corresponding to a combination of a mutant and a test case is, the higher the ranking priority for the combination of the mutant, the test case and a random seed is.", "In one embodiment, the ranking module calculates the ranking priority for the combination of a mutant, a test case and a random seed using the following formula: P m , t , s = F s × 1 d + F d × v c total + F D × D c total where, Pm,t,s is the ranking priority corresponding to the combination of the mutant, test case and random seed; Fs is a static distance adjusting factor which is a number between 0 and 1; Fd is a mutant activation cycle number adjusting factor which is a number between 0 and 1; FD is a mutant activation cycle number variance adjusting factor which is a number between 0 and 1; d is the distance between the mutant and the signal of the test case target; v is the mutant activation cycle number corresponding to the combination of the mutant, test case and random seed; D is the activation cycle number variance corresponding to the combination of the mutant and test case; ctotal is a total number of simulation cycles.", "In one embodiment, the apparatus further comprises (not shown in FIG.", "7): a combination selecting module configured to select part of the combinations of the mutants, test cases and random seeds based on the ranking of the combinations of the mutants, test cases and random seeds and testing requirements; and a mutation simulating module configured to perform a mutation simulation on the compiled integrated circuit under test using the selected combinations of the mutants, test cases and random seeds.", "In one embodiment, the apparatus further comprises (not shown in FIG.", "7): an evaluating module configured to evaluate, using the following formula, whether the selected combinations of the mutants, test cases and random seeds are suitable: Q p = Σ   activation   cycle   number   for   test   case   target related   to   selected   combinations number   of   test   case   targets   related   to   selected   combinations × average   of   activation   cycle   number   of   selected   combinations where, the bigger the Qp is, the more suitable the selected combinations are.", "In one embodiment, the apparatus further comprises (not shown in FIG.", "7): a re-ranking module configured to re-rank the combinations of the mutants, test cases and random seeds in response that the Qp does not meet a set threshold.", "The present invention may be a system, a method, and/or a computer program product.", "The computer program product may include a computer readable storage medium (or media) having computer readable program instructions thereon for causing a processor to carry out aspects of the present invention.", "The computer readable storage medium can be a tangible device that can retain and store instructions for use by an instruction execution device.", "The computer readable storage medium may be, for example, but is not limited to, an electronic storage device, a magnetic storage device, an optical storage device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination of the foregoing.", "A non-exhaustive list of more specific examples of the computer readable storage medium includes the following: a portable computer diskette, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or Flash memory), a static random access memory (SRAM), a portable compact disc read-only memory (CD-ROM), a digital versatile disk (DVD), a memory stick, a floppy disk, a mechanically encoded device such as punch-cards or raised structures in a groove having instructions recorded thereon, and any suitable combination of the foregoing.", "A computer readable storage medium, as used herein, is not to be construed as being transitory signals per se, such as radio waves or other freely propagating electromagnetic waves, electromagnetic waves propagating through a waveguide or other transmission media (e.g., light pulses passing through a fiber-optic cable), or electrical signals transmitted through a wire.", "Computer readable program instructions described herein can be downloaded to respective computing/processing devices from a computer readable storage medium or to an external computer or external storage device via a network, for example, the Internet, a local area network, a wide area network and/or a wireless network.", "The network may comprise copper transmission cables, optical transmission fibers, wireless transmission, routers, firewalls, switches, gateway computers and/or edge servers.", "A network adapter card or network interface in each computing/processing device receives computer readable program instructions from the network and forwards the computer readable program instructions for storage in a computer readable storage medium within the respective computing/processing device.", "Computer readable program instructions for carrying out operations of the present invention may be assembler instructions, instruction-set-architecture (ISA) instructions, machine instructions, machine dependent instructions, microcode, firmware instructions, state-setting data, or either source code or object code written in any combination of one or more programming languages, including an object oriented programming language such as Smalltalk, C++ or the like, and conventional procedural programming languages, such as the “C” programming language or similar programming languages.", "The computer readable program instructions may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server.", "In the latter scenario, the remote computer may be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet Service Provider).", "In some embodiments, electronic circuitry including, for example, programmable logic circuitry, field-programmable gate arrays (FPGA), or programmable logic arrays (PLA) may execute the computer readable program instructions by utilizing state information of the computer readable program instructions to personalize the electronic circuitry, in order to perform aspects of the present invention.", "Aspects of the present invention are described herein with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the invention.", "It will be understood that each block of the flowchart illustrations and/or block diagrams, and combinations of blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer readable program instructions.", "These computer readable program instructions may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks.", "These computer readable program instructions may also be stored in a computer readable storage medium that can direct a computer, a programmable data processing apparatus, and/or other devices to function in a particular manner, such that the computer readable storage medium having instructions stored therein comprises an article of manufacture including instructions which implement aspects of the function/act specified in the flowchart and/or block diagram block or blocks.", "The computer readable program instructions may also be loaded onto a computer, other programmable data processing apparatus, or other device to cause a series of operational steps to be performed on the computer, other programmable apparatus or other device to produce a computer implemented process, such that the instructions which execute on the computer, other programmable apparatus, or other device implement the functions/acts specified in the flowchart and/or block diagram block or blocks.", "The flowchart and block diagrams in the Figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present invention.", "In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s).", "It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures.", "For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved.", "It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems that perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.", "The descriptions of the various embodiments of the present invention have been presented for purposes of illustration, but are not intended to be exhaustive or limited to the embodiments disclosed.", "Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments.", "The terminology used herein was chosen to best explain the principles of the embodiments, the practical application or technical improvement over technologies found in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein." ] ]
Patent_15874375
[ [ "IMAGE PROCESSING DEVICE AND METHOD", "The present invention relates to an image processing device and method whereby deterioration of effects of filter processing due to local control of filter processing when encoding or decoding can be suppressed.", "A boundary control flag generating unit of a control information generating unit generates boundary control flags based on system specification information which a system specification managing unit manages.", "A control unit of an adaptive filter processing unit determines a processing method for filter processing to be performed as to pixels nearby a slice boundary following the value of the boundary control flag.", "For example, selection is made to perform filter processing straddling slices or to perform filter processing closed at the present slice.", "The present invention can be applied to an image processing device, for example." ], [ "1.An image decoding device comprising at least one processor and memory, the processor, working together with the memory, being configured to: decode a bit stream to generate decoded image data; decode a first control information indicating whether or not a filtering process is performed on an image block of image blocks of the decoded image data; decode a second control information indicating whether or not the filtering process is performed across a boundary of a current slice including the image block; derive a position of the image block, the position of the image block being obtained from block size information for the image block; when the first control information indicates the filtering process is not performed on the image block, the filtering process is not applied on any pixel of the image block; and when the first control information indicates the filtering process is performed on the image block, perform the filtering process on the image block based on the first control information, the second control information, and the position of the current image block.", "2.The image decoding device according to claim 1, wherein the second control information is included in a slice header of the current slice including the plurality of the image blocks.", "3.The image decoding device according to claim 1, wherein the processor, working together with the memory, is further configured to perform the filtering process on all pixels in the decoded image data when the first control information indicates that the filtering process is to be performed and the second control data indicates that the filtering process is performed across the boundary.", "4.The image decoding device according to claim 1, wherein the processor, working together with the memory, is further configured to perform the filtering process on all pixels exclusive of boundary pixels in the decoded image data when the first control information indicates that the filtering process is to be performed and the second control information indicates that the filtering process uses no pixels in a next slice.", "5.The image decoding device according to claim 1, wherein the processor, working together with the memory, is further configured to perform the filtering process on no pixel in the decoded image data when the first control information indicates that the filtering process is not to be performed and the second control information indicates that the filtering process uses no pixels in the next slice.", "6.The image decoding device according to claim 1, wherein the image decoding device further comprises a digital tuner, wherein the processor, working together with the memory and the digital tuner, is further configured to receive a broadcast wave signal of a digital broadcast including the encoded bit stream, the first control information, and second control information.", "7.An image decoding method, comprising: decoding a bit stream to generate decoded image data; decoding a first control information indicating whether or not a filtering process is performed on an image block of image blocks of the decoded image data; decoding a second control information indicating whether or not the filtering process is performed across a boundary of a current slice including the image block; deriving a position of the image block, the position of the image block being obtained from block size information for the image block; when the first control information indicates the filtering process is not performed on the image block, not performing the filtering process on any pixel of the image block; and when the first control information indicates the filtering process is performed on the image block, performing the filtering process on the image block based on the first control information, the second control information, and the position of the current image block.", "8.The image decoding method according to claim 7, wherein the second control information is included in a slice header of the current slice including the plurality of the image blocks.", "9.The image decoding method according to claim 7, further comprising: performing the filtering process on all pixels in the decoded image data when the first control information indicates that the filtering process is to be performed and the second control data indicates that the filtering process is performed across the boundary.", "10.The image decoding method according to claim 7, further comprising: performing the filtering process on all pixels exclusive of boundary pixels in the decoded image data when the first control information indicates that the filtering process is to be performed and the second control information indicates that the filtering process uses no pixels in a next slice.", "11.The image decoding method according to claim 7, further comprising: performing the filtering process on no pixel in the decoded image data when the first control information indicates that the filtering process is not to be performed and the second control information indicates that the filtering process uses no pixels in the next slice.", "12.The image decoding method according to claim 7, further comprising: receiving a broadcast wave signal of a digital broadcast including the encoded bit stream, the first control information, and second control information.", "13.A non-transitory computer readable medium encoded with a computer program that, when executed by a computer, causes the computer to implement an image decoding method comprising: decoding a bit stream to generate decoded image data; decoding a first control information indicating whether or not a filtering process is performed on an image block of image blocks of the decoded image data; decoding a second control information indicating whether or not the filtering process is performed across a boundary of a current slice including the image block; deriving a position of the image block, the position of the image block being obtained from block size information for the image block; when the first control information indicates the filtering process is not performed on the image block, not performing the filtering process on any pixel of the image block; and when the first control information indicates the filtering process is performed on the image block, performing the filtering process on the image block based on the first control information, the second control information, and the position of the current image block.", "14.The non-transitory computer readable medium according to claim 13, wherein the second control information is included in a slice header of the current slice including the plurality of the image blocks.", "15.The non-transitory computer readable medium according to claim 13, wherein the method further comprises: performing the filtering process on all pixels in the decoded image data when the first control information indicates that the filtering process is to be performed and the second control data indicates that the filtering process is performed across the boundary.", "16.The non-transitory computer readable medium according to claim 13, wherein the method further comprises: performing the filtering process on all pixels exclusive of boundary pixels in the decoded image data when the first control information indicates that the filtering process is to be performed and the second control information indicates that the filtering process uses no pixels in a next slice.", "17.The non-transitory computer readable medium according to claim 13, wherein the method further comprises: performing the filtering process on no pixel in the decoded image data when the first control information indicates that the filtering process is not to be performed and the second control information indicates that the filtering process uses no pixels in the next slice.", "18.The non-transitory computer readable medium according to claim 13, wherein the method further comprises: receiving a broadcast wave signal of a digital broadcast including the encoded bit stream, the first control information, and second control information." ], [ "<SOH> BACKGROUND ART <EOH>In recent years, there have come into widespread use devices, compliant to formats such as MPEG (Moving Picture Experts Group) or the like, which handle image information as digital signals, and take advantage of redundancy peculiar to the image information in order to perform highly effective information transmission and storage at that time, to compress the image by orthogonal transform such as discrete cosine transform or the like and motion compensation, as both information distribution such as broadcasting and information reception in general households.", "In particular, MPEG2 (ISO (International Organization for Standardization)/IEC (International Electrotechnical Commission) 13818-2) is defined as a general-purpose image encoding format, and is a standard encompassing both of interlaced scanning images and sequential-scanning images, and standard resolution images and high definition images.", "For example, MPEG2 has widely been employed now by broad range of applications for professional usage and for consumer usage.", "By employing the MPEG2 compression format, a code amount (bit rate) of 4 through 8 Mbps is allocated in the event of an interlaced scanning image of standard resolution having 720×480 pixels, for example.", "Also, by employing the MPEG2 compression format, a code amount (bit rate) of 18 through 22 Mbps is allocated in the event of an interlaced scanning image of high resolution having 1920×1088 pixels, for example, whereby a high compression rate and excellent image quality can be realized.", "With MPEG2, high image quality encoding adapted to broadcasting usage is principally taken as an object, but a lower code amount (bit rate) than the code amount of MPEG1, i.e., an encoding format having a higher compression rate is not handled.", "According to spread of personal digital assistants, it has been expected that needs for such an encoding format will be increased from now on, and in response to this, standardization of the MPEG4 encoding format has been performed.", "With regard to an image encoding format, the specification thereof was confirmed as international standard as ISO/IEC 14496-2 in December in 1998.Further, in recent years, standardization of a standard called H.26L (ITU-T (ITU Telecommunication Standardization Sector) Q6/16 VCEG (Video Coding Experts Group)) has progressed, originally intended for image encoding for videoconferencing usage.", "With H.26L, it has been known that as compared to a conventional encoding format such as MPEG2 or MPEG4, though greater computation amount is requested for encoding and decoding thereof, higher encoding efficiency is realized.", "Also, currently, as part of activity of MPEG4, standardization for also taking advantage of functions not supported by H.26L with this H.26L taken as a base, to realize higher encoding efficiency, has been performed as Joint Model of Enhanced-Compression Video Coding.", "As a schedule of standardization, H.264 and MPEG-4 Part 10 (AVC (Advanced Video Coding)) become an international standard in March, 2003.Also, there is adaptive loop filter (ALF (Adaptive Loop Filter)) as a next generation video encoding technique which is being considered as of recent (see NPL 1 for example).", "According to this adaptive loop filter, optimal filter processing is performed each frame, and block noise which was not completely removed at the deblocking filter, and noise due to quantization, can be reduced.", "However, images generally have various features, so optimal filter coefficients are locally different.", "With the method in NPL 1, the same filter coefficient is applied to all pixels within one frame, so the image quality of the overall frame improves, but there has been the concern that there may be local deterioration.", "Accordingly, there has been conceived not performing filter processing in regions which locally deteriorate (see NPL 2 and NPL 3, for example).", "In this case, the image encoding device corresponds multiple control blocks arrayed without gaps as if they were being used for paving, with regions of the image, and controls whether or not to perform filter processing on the image for each control block.", "The image encoding device sets flag information for each block, and performs adaptive filter processing according to the flag information.", "In the same way, the image decoding device also performs adaptive filter processing according to the flag information." ], [ "<SOH> SUMMARY OF INVENTION <EOH>" ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "15/190,930, filed Jun.", "23, 2016 (pending), which is a continuation of U.S. application Ser.", "No.", "14/293,787, filed Jun.", "2, 2014 (U.S. Pat.", "No.", "9,392,269, issued Jul.", "12, 2016), which is continuation of U.S. patent application Ser.", "No.", "13/942,335, filed Jul.", "15, 2013 (U.S. Pat.", "No.", "8,774,537, issued Jul.", "8, 2014), which is a continuation of U.S. patent application Ser.", "No.", "13/386,849, filed Jan. 24, 2012 (U.S. Pat.", "No.", "8,805,085, issued Aug. 12, 2014), and is based upon and claims the benefit of priority to International Application No.", "PCT/JP2010/062398, filed on Jul.", "23, 2010 and from the prior Japanese Patent Application No.", "2009-179395 filed on Jul.", "31, 2009.The entire contents of each of these documents are incorporated herein by reference.", "TECHNICAL FIELD The present invention relates to an image processing device and method, and specifically relates to an image processing device and method which enable suppression in deterioration of the effects of filter processing due to local control of filter processing when encoding or when decoding.", "BACKGROUND ART In recent years, there have come into widespread use devices, compliant to formats such as MPEG (Moving Picture Experts Group) or the like, which handle image information as digital signals, and take advantage of redundancy peculiar to the image information in order to perform highly effective information transmission and storage at that time, to compress the image by orthogonal transform such as discrete cosine transform or the like and motion compensation, as both information distribution such as broadcasting and information reception in general households.", "In particular, MPEG2 (ISO (International Organization for Standardization)/IEC (International Electrotechnical Commission) 13818-2) is defined as a general-purpose image encoding format, and is a standard encompassing both of interlaced scanning images and sequential-scanning images, and standard resolution images and high definition images.", "For example, MPEG2 has widely been employed now by broad range of applications for professional usage and for consumer usage.", "By employing the MPEG2 compression format, a code amount (bit rate) of 4 through 8 Mbps is allocated in the event of an interlaced scanning image of standard resolution having 720×480 pixels, for example.", "Also, by employing the MPEG2 compression format, a code amount (bit rate) of 18 through 22 Mbps is allocated in the event of an interlaced scanning image of high resolution having 1920×1088 pixels, for example, whereby a high compression rate and excellent image quality can be realized.", "With MPEG2, high image quality encoding adapted to broadcasting usage is principally taken as an object, but a lower code amount (bit rate) than the code amount of MPEG1, i.e., an encoding format having a higher compression rate is not handled.", "According to spread of personal digital assistants, it has been expected that needs for such an encoding format will be increased from now on, and in response to this, standardization of the MPEG4 encoding format has been performed.", "With regard to an image encoding format, the specification thereof was confirmed as international standard as ISO/IEC 14496-2 in December in 1998.Further, in recent years, standardization of a standard called H.26L (ITU-T (ITU Telecommunication Standardization Sector) Q6/16 VCEG (Video Coding Experts Group)) has progressed, originally intended for image encoding for videoconferencing usage.", "With H.26L, it has been known that as compared to a conventional encoding format such as MPEG2 or MPEG4, though greater computation amount is requested for encoding and decoding thereof, higher encoding efficiency is realized.", "Also, currently, as part of activity of MPEG4, standardization for also taking advantage of functions not supported by H.26L with this H.26L taken as a base, to realize higher encoding efficiency, has been performed as Joint Model of Enhanced-Compression Video Coding.", "As a schedule of standardization, H.264 and MPEG-4 Part 10 (AVC (Advanced Video Coding)) become an international standard in March, 2003.Also, there is adaptive loop filter (ALF (Adaptive Loop Filter)) as a next generation video encoding technique which is being considered as of recent (see NPL 1 for example).", "According to this adaptive loop filter, optimal filter processing is performed each frame, and block noise which was not completely removed at the deblocking filter, and noise due to quantization, can be reduced.", "However, images generally have various features, so optimal filter coefficients are locally different.", "With the method in NPL 1, the same filter coefficient is applied to all pixels within one frame, so the image quality of the overall frame improves, but there has been the concern that there may be local deterioration.", "Accordingly, there has been conceived not performing filter processing in regions which locally deteriorate (see NPL 2 and NPL 3, for example).", "In this case, the image encoding device corresponds multiple control blocks arrayed without gaps as if they were being used for paving, with regions of the image, and controls whether or not to perform filter processing on the image for each control block.", "The image encoding device sets flag information for each block, and performs adaptive filter processing according to the flag information.", "In the same way, the image decoding device also performs adaptive filter processing according to the flag information.", "CITATION LIST Non Patent Literature NPL 1: Yi-Jen Chiu and L. Xu, “Adaptive (Wiener) Filter for Video Compression,” ITU-T SG16 Contribution, C437, Geneva, April 2008.NPL 2: Takeshi.", "Chujoh, et al., “Block-based Adaptive Loop Filter” ITU-T SG16 Q6 VCEG Contribution, AI18, Germany, July, 2008 NPL 3: T. Chujoh, N. Wada and G Yasuda, “Quadtree-based Adaptive Loop Filter,” ITU-T SG16 Q6 VCEG Contribution, VCEG-AK22(r1), Japan, April, 2009 SUMMARY OF INVENTION Technical Problem However, there is a method in which one frame is divided into multiple slices, and encoding processing and decoding processing of the image is performed for each such slice (multi-slice).", "NPL 2 and NPL 3 make no mention regarding processing of pixels near boundaries of slices in such a multi-slice case, and how this should be processed has been unclear.", "The present invention has been proposed in light of this situation, and it is an object thereof to suppress deterioration of the effects of filter processing due to local control of filter processing when encoding or when decoding.", "Solution to Problem One aspect of the present invention is an image processing device including: determining means configured to determine whether or not there are included, in surrounding pixels of a pixel to be processed by filter processing locally performed on an image, pixels of a slice neighboring a slice in which the pixel to be processed is included; selecting means configured to select, from a plurality of methods, a method for the filter processing to be performed on the pixel to be processed, based on a boundary control flag, in the event that determination has been made by the determining means that a pixel of the neighboring slice is included in the surrounding pixels; and filter processing means configured to perform the filter processing as to the pixel to be processed with the method selected by the selecting means.", "The selecting means may select one of a method to perform the filter processing on the pixel to be processed after the surrounding pixels situated in the neighboring slice have been obtained, and a method to perform the filter processing on the pixel to be processed by generating dummy data of the surrounding pixels situated in the neighboring slice by duplicating the surrounding pixels situated in the slice including the pixel to be processed.", "The selecting means may select one of a method to perform the filter processing on the pixel to be processed after the surrounding pixels situated in the neighboring slice have been obtained, and a method to omit performing the filter processing on the pixel to be processed.", "The image processing device may further include: generating means configured to generate the boundary control flag based on system specifications; with the selecting means selecting a method of the filter processing as to the pixel to be processed, based on the boundary control flag generated by the generating means.", "The system specifications may include hardware resources of the image processing device.", "The system specifications may include the usage purpose of the image processing device.", "The image processing device may further include: encoding means configured to encode the image and generate encoded data; with the encoding means further encoding the boundary control flag generated by the generating means, and adding to the encoded data.", "The image processing device may further include: decoding means configured to decode encoded data of the image having been encoded, and generate the image; with the decoding means further decoding the encoded boundary control flag which has been added to the encoded data; and the selecting means selecting a method for the filter processing as to the pixel to be processed, based on the boundary control flag decoded by the decoding means.", "One aspect of the present invention also is an image processing method wherein determining means of an image processing device determine whether or not there are included, in surrounding pixels of a pixel to be processed by filter processing locally performed on an image, pixels of a slice neighboring a slice in which the pixel to be processed is included, selecting means of the image processing device select, from a plurality of methods, a method for the filter processing to be performed on the pixel to be processed, based on a boundary control flag, in the event that determination has been made that a pixel of the neighboring slice is included in the surrounding pixels, and filter processing means of the image processing device perform the filter processing as to the pixel to be processed with the method that has been selected.", "With an aspect of the present invention, determination is made regarding whether or not there are included, in surrounding pixels of a pixel to be processed by filter processing locally performed on an image, pixels of a slice neighboring a slice in which the pixel to be processed is included, a method for the filter processing to be performed on the pixel to be processed is selected from a plurality of methods, based on a boundary control flag, in the event that determination has been made that a pixel of the neighboring slice is included in the surrounding pixels, and the filter processing is performed as to the pixel to be processed with the method that has been selected.", "Advantageous Effects of Invention According to the present invention, an image can be encoded or decoded.", "Particularly, deterioration of effects of filter processing due to local control of filter processing when encoding or decoding can be suppressed.", "For example, the deterioration in the effects of filter processing can be suppressed even in case of performing encoding or decoding with each frame of an image divided into a plurality.", "BRIEF DESCRIPTION OF DRAWINGS FIG.", "1 is a block diagram illustrating the configuration of an embodiment of an image encoding device to which the present invention has been applied.", "FIG.", "2 is a diagram describing variable block size motion prediction/compensation processing.", "FIG.", "3 is a block diagram illustrating a primary configuration example of a control information generating unit.", "FIG.", "4 is a diagram describing ALF blocks and filter block flags.", "FIG.", "5 is a diagram describing an example of multi-slice.", "FIG.", "6 is a diagram describing surrounding pixels used for filter processing.", "FIG.", "7 is a diagram describing the way in which filter processing is performed close to a boundary.", "FIG.", "8 is a block diagram illustrating a primary configuration example of an adaptive filter processing unit.", "FIG.", "9 is a flowchart describing an example of the flow of encoding processing.", "FIG.", "10 is a flowchart describing an example of the flow of control information generating processing.", "FIG.", "11 is a flowchart describing an example of the flow of boundary control flag setting processing.", "FIG.", "12 is a flowchart describing an example of the flow of adaptive filter control processing.", "FIG.", "13 is a flowchart describing an example of the flow of filter processing.", "FIG.", "14 is a flowchart describing an example of the flow of filter processing.", "FIG.", "15 is a block diagram illustrating a primary configuration example of an image decoding device to which the present invention has been applied.", "FIG.", "16 is a flowchart describing an example of the flow of decoding processing.", "FIG.", "17 is a block diagram illustrating another configuration example of an image encoding device to which the present invention has been applied.", "FIG.", "18 is a block diagram illustrating another configuration example of an image decoding device to which the present invention has been applied.", "FIG.", "19 is a flowchart describing an example of the flow of processing for exchanging specification information.", "FIG.", "20 is a diagram describing another example of ALF blocks and filter block flags.", "FIG.", "21 is a diagram describing another example of ALF blocks and filter block flags.", "FIG.", "22 is a diagram describing the way of processing is performed in the case of multi-slice.", "FIG.", "23 is a block diagram illustrating a primary configuration example of a personal computer to which the present invention has been applied.", "FIG.", "24 is a block diagram illustrating a principal configuration example of a television receiver to which the present invention has been applied.", "FIG.", "25 is a block diagram illustrating a principal configuration example of a cellular telephone to which the present invention has been applied.", "FIG.", "26 is a block diagram illustrating a principal configuration example of a hard disk recorder to which the present invention has been applied.", "FIG.", "27 is a block diagram illustrating a principal configuration example of a camera to which the present invention has been applied.", "FIG.", "28 is a diagram illustrating an example of macro blocks.", "DESCRIPTION OF EMBODIMENTS Hereinafter, embodiments of the present invention will be described.", "Note that description will proceed in the following order.", "1.First Embodiment (image encoding device) 2.Second Embodiment (image decoding device) 3.Third Embodiment (image encoding/decoding system) 4.Fourth Embodiment (QALF) 5.Fifth Embodiment (personal computer) 6.Sixth Embodiment (television receiver) 7.Seventh Embodiment (cellular telephone) 8.Eighth Embodiment (hard disk recorder) 9.Ninth Embodiment (camera) 1.First Embodiment [Configuration of Device] FIG.", "1 represents the configuration of an embodiment of an image encoding device serving as an image processing device to which the present invention has been applied.", "An image encoding device 100 shown in FIG.", "1 is an image encoding device which subjects an image to compression encoding using, for example, the H.264 and MPEG-4 Part 10 (Advanced Video Coding) (hereafter, written as H.264/AVC) format, and further employs an adaptive loop filter.", "With the example in FIG.", "1, the image encoding device 100 has an A/D (Analog/Digital) conversion unit 101, a screen rearranging buffer 102, a computing unit 103, an orthogonal transform unit 104, a quantization unit 105, a lossless encoding unit 106, and a storing buffer 107.The image encoding device 100 also has an inverse quantization unit 108, an inverse orthogonal transform unit 109, a computing unit 110, and a deblocking filter 111.Further, the image encoding device 100 has a control information generating unit 112, an adaptive filter processing unit 113, and frame memory 114.Also, the image encoding device 100 has an intra prediction unit 115, a motion compensation unit 116, a motion prediction unit 117, and a prediction image selecting unit 118.Further, the image encoding device 100 has a rate control unit 119.The A/D conversion unit 101 performs A/D conversion of an input image, and outputs to the screen rearranging buffer 102 and stores.", "The screen rearranging buffer 102 rearranges the images of frames in the stored order for display into the order of frames for encoding according to GOP (Group of Picture).", "The computing unit 103 subtracts from the image read out from the screen rearranging buffer 102 the prediction image from the intra prediction unit 115 selected by the prediction image selecting unit 118 or the prediction image from the motion compensation unit 116, and outputs difference information thereof to the orthogonal transform unit 104.The orthogonal transform unit 104 subjects the difference information from the computing unit 103 to orthogonal transform, such as discrete cosine transform, Karhunen-Loéve transform, or the like, and outputs a transform coefficient thereof.", "The quantization unit 105 quantizes the transform coefficient that the orthogonal transform unit 104 outputs.", "The quantized transform coefficient that is the output of the quantization unit 105 is input to the lossless encoding unit 106, where it is subjected to lossless encoding, such as variable length coding, arithmetic coding, or the like, and compressed.", "The lossless encoding unit 106 obtains information indicating intra prediction and so forth from the intra prediction unit 115, and obtains information indicating an inter prediction mode, and so forth from the motion prediction unit 117.Note that the information indicating intra prediction will also be referred to as intra prediction mode information hereinafter.", "Also, the information indicating inter prediction will also be referred to as inter prediction mode information hereinafter.", "The lossless encoding unit 106 obtains control information of adaptive filter processing performed at the adaptive filter processing unit 113 from the control information generating unit 112.The lossless encoding unit 106 encodes the quantized transform coefficient, and also encodes the control information of adaptive filter processing, the information indicating intra prediction, the information indicating an inter prediction mode, quantization parameters, and so forth, and takes these as part of header information in the compressed image (multiplexes).", "The lossless encoding unit 106 supplies the encoded data to the storing buffer 107 for storage.", "For example, with the lossless encoding unit 106, lossless encoding processing, such as variable length coding, arithmetic coding, or the like, is performed.", "Examples of the variable length coding include CAVLC (Context-Adaptive Variable Length Coding) determined by the H.264/AVC format.", "Examples of the arithmetic coding include CABAC (Context-Adaptive Binary Arithmetic Coding).", "The storing buffer 107 temporarily holds the data supplied from the lossless encoding unit 106, and at a predetermined timing outputs this to, for example, a storage device or transmission path or the like downstream not shown in the drawing, as a compressed image encoded by the H.264/AVC format.", "Also, the quantized transform coefficient output from the quantization unit 105 is also input to the inverse quantization unit 108.The inverse quantization unit 108 performs inverse quantization of the quantized transform coefficient with a method corresponding to quantization at the quantization unit 105, and supplies the obtained transform coefficient to the inverse orthogonal transform unit 109.The inverse orthogonal transform unit 109 performs inverse orthogonal transform of the supplied transform coefficients with a method corresponding to the orthogonal transform processing by the orthogonal transform unit 104.The output subjected to inverse orthogonal transform is supplied to the computing unit 110.The computing unit 110 adds the prediction image supplied from the prediction image selecting unit 118 to the inverse orthogonal transform result supplied from the inverse orthogonal transform unit 109, i.e., the restored difference information, and obtains a locally decoded image (decoded image).", "The addition results thereof are supplied to the deblocking filter 111.The deblocking filter 111 removes block noise from the decoded image.", "The deblocking filter 111 then supplies the noise removal results to the control information generating unit 112 and the adaptive filter processing unit 113.The control information generating unit 112 obtains the decoded image supplied from the deblocking filter 111 and the current input image read out from the screen rearranging buffer 102, and generates from these control information for adaptive filtering to be performed at the adaptive filter processing unit 113.While details will be described later, the control information includes filter coefficients, block size, filter block flags, and boundary control flags and the like.", "The control information generating unit 112 supplies the generated control information to the adaptive filter processing unit 113.The control information generating unit 112 also supplies the generated control information to the lossless encoding unit 106 as well.", "As described above, the control information is subjected to lossless compression processing by the lossless encoding unit 106, and included in the image compressed information (multiplexed).", "That is to say, the control information is sent to the image decoding device along with the image compression information.", "The adaptive filter processing unit 113 performs filter processing on the decoded image supplied form the deblocking filter 111, using the filter coefficients, block size specification, and filter block flags and the like, of the control information supplied from the control information generating unit 112.A Wiener filter (Wiener Filter), for example, is used as this filter.", "Of course, a filer other than a Wiener filter may be used.", "The adaptive filter processing unit 113 supplies the filter processing results to the frame memory 114, and stores as a reference image.", "The frame memory 114 outputs the stored reference image to the motion compensation unit 116 and motion prediction unit 117 at a predetermined timing.", "With this image encoding device 100, the I picture, B picture, and P picture from the screen rearranging buffer 102 are supplied to the intra prediction unit 115 as an image to be subjected to intra prediction (also referred to as intra processing), for example.", "Also, the B picture and P picture read out from the screen rearranging buffer 102 are supplied to the motion compensation unit 117 as an image to be subjected to inter prediction (also referred to as inter processing).", "The intra prediction unit 115 performs intra prediction processing of all of the candidate intra prediction modes based on the image to be subjected to intra prediction read out from the screen rearranging buffer 102, and the reference image supplied from the frame memory 114 to generate a prediction image.", "With the intra prediction unit 115, information relating to the intra prediction mode applied to the current block/macroblock is transmitted to the lossless encoding unit 106, and is encoded as a part of the header information in the image compression information.", "With the H.264 image information encoding format, the intra 4×4 prediction mode, intra 8×8 prediction mode, and intra 16×16 prediction mode are defined for luminance signals, and also with regard to color difference signals, a prediction mode can be defined for each macroblock, independent from the luminance signals.", "For the intra 4×4 prediction mode, one intra prediction mode is defined for each 4×4 luminance block.", "For the intra 8×8 prediction mode, one intra prediction mode is defined for each 8×8 luminance block.", "For the intra 16×16 prediction mode and color difference signals, one intra prediction mode is defined for each macroblock.", "The intra prediction unit 115 calculates a cost function value as to the intra prediction mode where the prediction image has been generated, and selects the intra prediction mode where the calculated cost function value gives the minimum value, as the optimal intra prediction mode.", "The intra prediction unit 115 supplies the prediction image generated in the optimal intra prediction mode to the prediction image selecting unit 118.With regard to the image to be subjected to inter encoding, the motion prediction unit 117 obtains image information supplied from the screen rearranging buffer 102 (input image) and image information serving as the reference frame supplied from the frame memory 114 (decoded image), and calculates a motion vector.", "The motion prediction unit 117 supplies motion vector information indicating the calculated motion vector to the lossless encoding unit 106.This motion vector information is subjected to lossless compression processing by the lossless encoding unit 106, and included in the image compressing information.", "That is to say the motion vector information is sent to the image decoding device along with the image compression information.", "Also, the motion prediction unit 117 also supplies the motion vector information to the motion compensation unit 116.The motion compensation unit 116 performs motion compensation processing in accordance with the motion vector information supplied from the motion prediction unit 117, and generates inter prediction image information.", "The motion compensation unit 116 supplies the generated prediction image information to the prediction image selecting unit 118.In the case of an image for performing intra encoding, the prediction image selecting unit 118 supplies the output of the intra prediction unit 115 to the computing unit 103, and in the event of an image for performing inter encoding, supplies the output of the motion compensation unit 116 to the computing unit 103.The rate control unit 119 controls the rate of quantization operations of the quantization unit 105 based on the compressed image stored in the storing buffer 107, such that overflow or underflow does not occur.", "With MPEG (Moving Picture Experts Group) 2, the increments of motion prediction/compensation processing is motion compensation blocks, and independent motion vector information can be held at each motion compensation block.", "The size of a motion compensation block is 16×16 pixels in the case of frame motion compensation mode, and in the case of field motion compensation mode is 16×8 pixels for each of the first field and the second field.", "On the other hand, with AVC (Advanced Video Coding), one macroblock configured of 16×16 pixels, as shown at the upper side in FIG.", "2, can be divided into any of the partitions of 16×16, 16×8, 8×16, or 8×8, with each holding independent motion vector information.", "Also, as shown at the lower side in FIG.", "2, a 8×8 partition can be divided into any of the sub partitions of 8×8, 8×4, 4×8, or 4×4, with each holding independent motion vector information.", "Motion prediction/compensation processing is performed with this motion compensation block as an increment.", "FIG.", "3 is a block diagram illustrating a primary configuration example of the control information generating unit 112.The control information generating unit 112 generates control information used at the adaptive filter (ALF (Adaptive Loop Filter)) which is a loop filter, performed at the adaptive filter processing unit 113.The control information generating unit 112 generates, as the control information, filter coefficients, ALF block size, filter block flags, and boundary control flags, for example.", "The control information generating unit 112 has a filter coefficient calculating unit 131, boundary control flag generating unit 132, and block information generating unit 133.The filter coefficient calculating unit 131 obtains the decoded image supplied from the deblocking filter 111 and current input image read out from the screen rearranging buffer 102, and calculates an ALF filter coefficient for each frame.", "The boundary control flag generating unit 132 generates a boundary control flag (alf_enable_in_slice_boundary) which controls how filter processing is to be performed as to pixels near the boundary of slices, of which a plurality is formed in the frame (specifies filter processing method).", "Details will be described later.", "The block information generating unit 133 determines the ALF block size based on the decoded image supplied from the deblocking filter 111 and the filter coefficients calculated by the filter coefficient calculating unit 131, and generates a filter block flag for each ALF block within the slice to be processed.", "Now, description will be made regarding the ALF block and filter block flag.", "FIG.", "4 is a diagram for describing ALF blocks and filter block flags.", "As described above, the adaptive filter has filter coefficients set for each frame.", "That is to say, optimal filter processing is performed in increments of frames.", "However, generally, frame images are not uniform overall, and have various features locally.", "Therefore, optimal filter coefficients differ locally.", "Accordingly, while the filter processing using filter coefficients determined each frame as described above improve the image quality for the overall frame, there has been concern that this will in fact deteriorate locally.", "Accordingly, BALF (Block based Adaptive Loop Filter) in which filter processing is not performed at regions where image quality locally deteriorates, has been conceived.", "A decoded image following deblocking filter processing is shown in frame 151 in A in FIG.", "4.As shown in B in FIG.", "4, the block information generating unit 133 arrays multiple ALF blocks 152, which are control blocks serving as the increment of control for adaptive filter processing locally performed, without gaps as if they were being used for paving the entire region of the frame 151.The region where the ALF blocks 152 are placed does not have to be the same as the region of the frame 151, but includes at least the entire region of the frame.", "The region of the frame 151 is resultantly divided into the regions of the ALF blocks 152 (multiple regions).", "The block information generating unit 133 determines the horizontal direction size (both-sided arrow 153) and vertical direction size (both-sided arrow 154) of the ALF blocks 152.For the size of the ALF blocks, one of 8×8, 16×16, 24×24, 32×32, 48×48, 64×64, 96×96, or 128×128, can be specified for each slice.", "The information specifying the size of the ALF block will be called block size index.", "Once the block size is decided, the number of ALF blocks per frame has also been decided, since the frame size is fixed.", "As shown in C in FIG.", "4, the block information generating unit 133 sets a filter block flag 155 which controls whether or not to perform filter processing, in each Alf block 152.For example, a filter block flag 155 with a value of “1” is generated for a region where the image quality is improved by the adaptive filter, and a filter block flag 155 with a value of “0” is generated for a region where the image quality is deteriorated by the adaptive filter.", "With the filter block flag 155, the value of “1” is a value indicating that filter processing is to be performed, and the value of “0” is a value indicating that filter processing is not to be performed.", "The adaptive filter processing unit 113 controls the adaptive filter processing based on the value of the filter block flag 155.For example, the adaptive filter processing unit 113 performs filter processing only at the regions where the ALF blocks 152 have a value of “1” for the filter flag 155, and does not perform filter processing at the regions where the ALF blocks 152 have a value of “0” for the filter flag 155.Also, the above-described block size index and filter block flag are included in the slice header of the image compression information, and sent from the image encoding device 100 to the image decoding device.", "The one or more filter block flags corresponding to the number of ALF blocks are included in the slice header in the order of raster scan, for example.", "Accordingly, the smaller the size of the ALF block, the finer filter control can be realized, and more appropriate ALF filtering can be performed.", "However, smaller ALF block size increases the bit amount of the filter block flags.", "That is to say, the smaller the ALF block size is the more the encoding efficiency of the image compression information decreases.", "Thus, the capabilities of the adaptive filter and the encoding efficiency of the image compression information are in a tradeoff relation.", "The number of ALF blocks is calculated as with the following Expression (1).", " [ Mathematical   Expression   1 ] N ALFBLOCK = floor  [ 16 × N MBw + N SIZE - 1 N SIZE ] × floor  [ 16 × N MBh + N SIZE - 1 N SIZE ] ( 1 ) In Expression (1), NALFBLOCK represents the number of ALF blocks.", "Also, NMBw represents the number of macro blocks in the horizontal direction of the picture, and NMBh represents the number of macro blocks in the vertical direction of the picture.", "Further, NSIZE represents the size of one side of an ALF block.", "Also, floor[x] is a function where x is rounded off to the decimal so as to be an integer.", "Now, with H.264/AVC, once frame can be divided into multiple slices, and image compression information can be output for each slice.", "FIG.", "5 is a diagram for describing an example of multi-slice.", "In the case of the example in FIG.", "5, the frame 151 is divided into the three slices of slice 0, slice 1, and slice 2.By outputting image compression information in finer slice increments than frames, the image encoding device can generate and output image compression information at shorter intervals.", "That is to say, the image decoding device which decodes the image compression information can start decoding of the image compression information at an earlier stage.", "That is to say, the delay time from the image being input to encoding processing and encoding processing being performed and the image being output can be shortened.", "NPL 2 which describes BALF does not disclose this multi-slice.", "That is to say, only setting ALF blocks for the entire frame is described.", "However, in the case of multi-slice, there are cases where normal filter processing cannot be performed as to pixels near the boundary of slices.", "FIG.", "6 is a diagram illustrating the way in which filter processing is performed as to pixels near the slice boundary.", "In the case of performing filter processing as to the pixels to be processed, the adaptive filter processing unit 113 performs this using pixels within a predetermined range around the pixel to be processed (surrounding pixels).", "For example, in the case of FIG.", "6, the adaptive filter processing unit 113 performs filter processing on a pixel to be processed 161 using 9×9 surrounding pixels 162 shown with hatching.", "However, as shown in FIG.", "6, the pixel to be processed 161 is a pixel near the slice boundary 163.Now, the slice boundary 163 indicates the boundary between a slice to be currently processed (current slice) and a slice neighboring the slice to be processed (neighboring slice).", "That is to say, the slice boundary 163 indicates the outer frame of the current slice.", "As shown in FIG.", "6, surrounding pixels 162 used for filter processing of the pixel to be processed 161 near the slice boundary 163 partially cross over the slice boundary 163 and straddle the region of the neighboring slice.", "That is to say, in order to perform filter processing of the pixel to be processed 161 in the same way as with a normal case, the pixel values of the neighboring slice are necessary, as shown in A in FIG.", "7 for example.", "In the case of the example in A in FIG.", "7, the adaptive filter processing unit 113 performs filter processing as to the pixel EE which is the pixel to be processed, using the pixel AA through pixel JJ in both the current slice and the neighboring slice.", "However, in order to do this, generating of the decoded image of the neighboring slice needs to be waited for.", "Accordingly, in this case, there has been the concern that the delay time of encoding processing would increase.", "On the other hand, there is a method for generating and using dummy data, as shown in B in FIG.", "7, for example.", "In the case of the example in B in FIG.", "7, the adaptive filter processing unit 113 duplicates the pixel EA through pixel EJ adjacent to the slice boundary 163, thereby generating pixels within the neighboring slice for the surrounding pixels 162 (dummy data).", "The adaptive filter processing unit 113 performs filter processing as to the pixel EE using the generated dummy data.", "Thus, the adaptive filter processing unit 113 does not need to wait for pixels of the neighboring slice to be generated, and filter processing of the pixel EE can be performed at an earlier stage than with the case of A in FIG.", "7.That is to say, with the case of the method of A in FIG.", "7 using the pixels of the neighboring slice, the adaptive filter processing unit 113 uses actual data, so filter processing can be performed more suitable for the contents of the actual image.", "That is to say, great improvement of image quality due to filter processing can be expected.", "On the other hand, in the case of the method in B in FIG.", "7, the adaptive filter processing unit 113 does not need data of the adjacent slice for filter processing, and processing can be performed with the data of the current slice alone, so filter processing can be performed at an earlier stage.", "Which method is desirable differs depending on the system specifications, user requests, and so forth.", "For example, if the system emphasizes image quality, the method shown in A in FIG.", "7, but the method in A in FIG.", "7 consumes a greater amount of memory than the method in B in FIG.", "7, and there is the concern that the delay time will increase.", "Accordingly, depending on the memory capacity which can be used with the system and the tolerable delay time length, there may be causes where the method of B in FIG.", "7 is more desirable.", "The boundary control flag controls the method of filter processing as to such pixels near a boundary.", "Returning to FIG.", "3, the boundary control flag generating unit 132 generates such boundary control flags.", "The boundary control flag generating unit 132 has a system specification managing unit 141, a determining unit 142, and a generating unit 143.The system specification managing unit 141 manages the specifications of the system performing image processing (hardware resources, usage purpose, etc.)", "including the image encoding device 100.For example, the system specification managing unit 141 may be arranged to manage the specifications (hardware resources, usage purpose, etc.)", "of the image decoding device encoded at the image encoding device 100.The determining unit 142 determines whether or not the pixel to be processed is a pixel near the boundary.", "The generating unit 143 generates boundary control flags for the pixels to be processed which have been determined to be pixels near the boundary.", "FIG.", "8 is a block diagram illustrating a primary configuration example of the adaptive filter processing unit 113 in FIG.", "1.The adaptive filter processing unit 113 performs filter processing on the decoded image supplied from the deblocking filter 111 using the control information supplied from the control information generating unit 112.As shown in FIG.", "9, the adaptive filter processing unit 113 has a control unit 171, an adaptive filter 172, and a selecting unit 173.The control unit 171 controls the adaptive filter 172 and the selecting unit 173.For example, the control unit 171 obtains control information from the control information generating unit 112, and controls the filter processing based on this control information.", "The adaptive filter 172 performs filter processing of a region in the decoded image supplied from the deblocking filter 111, specified as ALF blocks to be processed from the control unit 171, using a filter coefficient set by the control unit 171.The adaptive filter 172 has a buffer 181, an in-slice adaptive filter 182, a first adaptive filter for boundary 183, and a second adaptive filter for boundary 184.The buffer 181 temporarily holds a decoded image supplied from the deblocking filter 111.The buffer 181 can hold not only the slice to be processed, but also the slice neighboring the slice to be processed (neighboring slice).", "The in-slice adaptive filter 182 performs filter processing as to pixels to be processed which are not near the slice boundary and regarding which pixels of the neighboring slice are not included in the surrounding pixels, under control of the control unit 171.That is to say, the in-slice adaptive filter 182 performs filter processing using only pixels of the current slice.", "The first adaptive filter for boundary 183 performs filter processing straddling slices on pixels to be processed which are near the slice boundary and regarding which pixels of the neighboring slice are included in the surrounding pixels, under control of the control unit 171.That is to say, the first adaptive filter for boundary 183 performs filter processing using the pixels of the current slice and neighboring slice, with a method such as shown in A in FIG.", "7.Accordingly, the first adaptive filter for boundary 183 starts filter processing after pixels of the adjacent slice have been accumulated in the buffer 181.The second adaptive filter for boundary 184 performs filter processing closed to the current slice, on pixels to be processed which are near the slice boundary and regarding which pixels of the neighboring slice are included in the surrounding pixels, under control of the control unit 171.That is to say, the second adaptive filter for boundary 184 performs filter processing by generating dummy data as necessary, using the pixels of the current slice alone, with a method such as shown in B in FIG.", "7.Accordingly, the second adaptive filter for boundary 184 starts filter processing upon pixels of the current slice being accumulated in the buffer 181.The control unit 171 selects one of the in-slice adaptive filter 182, first adaptive filter for boundary 183, and second adaptive filter for boundary 184, following the position of the pixel to be processed and the value of the boundary control flag included in the control information, and causes the selected processing unit to execute filter processing with its own method.", "Also, the control unit 171 controls the filter processing start timing of the selected processing unit (in-slice adaptive filter 182, first adaptive filter for boundary 183, or second adaptive filter for boundary 184), in accordance with the accumulation state of the image in the buffer 181.The adaptive filter 172 (in-slice adaptive filter 182, first adaptive filter for boundary 183, or second adaptive filter for boundary 184) supplies the filter processing results to the selecting unit 173.Under control of the control unit 171, the selecting unit 173 selects one of the decoded image supplied from the deblocking filter 111 (decoded image not subjected to adaptive filter processing) and the decoded image supplied from the adaptive filter 172 (decoded image subjected to adaptive filter processing), supplies this to the frame memory 114, and stores as a reference image.", "The control unit 171 controls the selecting unit 173 following the value of the filter block flag included in the control information to select one of the decoded image not subjected to adaptive filter processing and the decoded image subjected to adaptive filter processing.", "That is to say, the adaptive filter processing unit 113 performs filter processing only for a region in the decoded image supplied from the deblocking filter 111 regarding which indication has been made to perform filter processing by the filter block flag (region regarding which determination has been made that image quality will be improved by filter processing).", "[Flow of Processing] Next, the flow of processing using the portions configured as described above will be described.", "First, an example of the low of encoding processing performed by the image encoding device 100 will be described with reference to the flowchart in FIG.", "9.In step S101, the A/D conversion unit 101 converts an input image from analog to digital.", "In step S102, the screen rearranging buffer 102 stores the A/D converted image, and performs rearranging from the sequence for displaying the pictures to the sequence for encoding.", "In step S103, the computing unit 103 computes difference between an image rearranged by the processing in step S102 and the prediction image.", "The prediction image is supplied to the computing unit 103 from the motion compensation unit 116 in the event of performing inter prediction, and from the intra prediction unit 115 in the event of performing intra prediction, via the prediction image selecting unit 118.The difference data is smaller in the data amount as compared to the original image data.", "Accordingly, the data amount can be compressed as compared to the case of encoding the original image without change.", "In step S104, the orthogonal transform unit 104 subjects the difference information generated by the processing in step S103 to orthogonal transform.", "Specifically, orthogonal transform, such as discrete cosine transform, Karhunen-Loéve transform, or the like, is performed, and a transform coefficient is output.", "In step S105, the quantization unit 105 quantizes the transform coefficient.", "At the time of this quantization, a rate is controlled such as later-described processing in step S119 will be described.", "The difference information thus quantized is locally decoded as follows.", "Specifically, in step S106, the inverse quantization unit 108 subjects the transform coefficient quantized by the quantization unit 105 to inverse quantization using a property corresponding to the property of the quantization unit 105.In step S107, the inverse orthogonal transform unit 109 subjects the transform coefficient subjected to inverse quantization by the inverse quantization unit 108 to inverse orthogonal transform using a property corresponding to the property of the orthogonal transform unit 104.In step S108 the computing unit 110 adds the prediction image input via the prediction image selecting unit 118 to the locally decoded difference information, and generates a locally decoded image (the image corresponding to the input to the computing unit 103).", "In step S109, the deblocking filter 111 subjects the image output from the computing unit 110 to filtering.", "Thus, block noise is removed.", "Upon the above processing being performed for one slice, in step S110 the control information generating unit 112 generates control information to be used for adaptive filter processing.", "The details of the control information generating processing will be described later in detail.", "Upon control information such as filter coefficients, ALF block size, and filter block flag and the like being generated by the processing in step S110, in step S111 the adaptive filter processing unit 113 performs adaptive filter processing on the decoded image subjected to the deblocking filter processing in the processing of step S109.Details of this adaptive filter processing will be described later.", "In step S112, the frame memory 114 stores the image subjected to adaptive filter processing in step S111.In step S113, the intra prediction unit 115 performs intra prediction processing in the intra prediction mode.", "In step S114, the motion prediction unit 117 and motion compensation unit 116 perform motion prediction/compensation processing in the inter prediction mode.", "In step S115, the prediction image selecting unit 118 selects one of a prediction image generated by intra prediction processing or a prediction image generated by inter motion prediction/compensation processing, in accordance with the prediction mode of the frame to be processed.", "The prediction image selecting unit 118 supplies the selected prediction image to the computing units 103 and 110.This prediction image is, as described above, used for calculations in steps S103 and S108.In step S116, the lossless encoding unit 106 encodes the quantized transform coefficient output from the quantization unit 105.Specifically, the difference image is subjected to lossless encoding such as variable length coding, arithmetic coding, or the like, and compressed.", "At this time, the lossless encoding unit 106 also encodes the control information generated in step S110, the intra prediction mode information for intra prediction processing in step S113, the inter prediction mode for inter motion prediction/compensation processing in step S114, and so forth.", "In step S117, the lossless encoding unit 106 embeds (describes) metadata such as the encoded control information and so forth in the slice header.", "This metadata read out and used for when performing image decoding.", "By including (multiplexing) the metadata necessary for decoding processing in this way, execution of decoding processing is enabled in increments finer than frame increments, and increase of delay time can be suppressed.", "In step S118, the storing buffer 107 stores a difference image as a compressed image.", "The compressed image stored in the storing buffer 107 is read out as appropriate and transmitted to the decoding side via the transmission path.", "In step S119, the rate control unit 119 controls the rate of the quantization operation of the quantization unit 105, so that overflow or underflow does not occur, based on the compressed image stored in the storing buffer 107.Next, description will be made of an example of the flow of control information generating processing executed by the control information generating unit 112 in step S110 in FIG.", "10 will be described with reference to the flowchart in FIG.", "11.Upon the control information generating processing being started, the filter coefficient calculating unit 131 of the control information generating unit 112 calculates a filter coefficient using the input image supplied from the screen rearranging buffer 102 and the decoded image subjected to deblocking filter processing that is supplied from the deblocking filter 111.For example, the filter coefficient calculating unit 131 determines the value of the filter coefficient such that the residual of the input image and decoded image is the smallest.", "Upon the filter coefficient being calculated, in step S132 the boundary control flag generating unit 132 generates a boundary control flag for controlling the adaptive filter processing method as to the pixel near the boundary.", "Details will be described later.", "Upon a boundary control flag being generated, in step S133 the block information generating unit 133 generates block information including ALF block size and filter block flag.", "The ALF block size may be determined beforehand, or may be set as appropriate in accordance with the contents of the image.", "In this case, the block information generating unit 133 calculates a cost value evaluating the filter processing results using a cost function, and determines the ALF block size such that the cost value is the smallest, for example.", "Also, the block information generating unit 133 determines the value of the filter block flag depending on whether the image quality is improved in the event that the filter processing is applied to the ALF block to be processed.", "For example, in the event of determining that image quality is improved by applying the filter processing, the block information generating unit 133 sets the value of the filter block flag to “1” which indicates that filter processing is to be performed, and in the event of determining that image quality deteriorates by applying the filter processing, sets the value of the filter block flag to “0” which indicates that filter processing is not to be performed.", "Upon block information being generated, the flow returns to step S110 in FIG.", "9, and processing from step S111 and on is performed.", "Note that the calculation of the filter coefficient performed in step S131 may be performed in frame increments.", "In this case, the processing in step S131 may be performed only on a predetermined slice within the frame (e.g., a slice where the identification number within the frame is a predetermined value (e.g., “0”), or a slice first processed within the frame, or the like), with this value used for the other slices.", "Also, an arbitrary image can be used for calculation of filter coefficients.", "For example, calculation may be performed based on past frame images.", "Next, an example of the flow of boundary control flag setting processing executed in step S132 in FIG.", "10 will be described with reference to the flowchart in FIG.", "11.Upon the boundary control flag setting processing being started, in step S151 the system specification managing unit 141 of the boundary control flag generating unit 132 obtains system specification information.", "This system specification information is information including the hardware resources and usage purpose and so forth of the system including the image encoding device 100, for example.", "Hardware resources are hardware resources of the devices configuring the system (including the image encoding device 100), and for example includes processing capabilities, usable memory capacity, bus transmission speed, and so forth.", "Also, usage purpose is the operation mode of the overall system or individual devices, and includes, for example, whether to operate with emphasis on image quality, whether to operate with emphasis on speed, and so forth.", "Of course, information other that these may be included in the system specification information.", "This system specification information may be stored beforehand in memory or the like built into the system specification managing unit 141.In this case, the system specification managing unit 141 reads out the system specification information from the memory by the processing in step S151.Also, at the time of the processing in step S151, the system specification managing unit 141 may collect specification information such as described above from parts of the image encoding device 100 and from other devices and so forth.", "Upon obtaining the system specification information, the system specification managing unit 141 supplies this to the determining unit 142.In step S152, the determining unit 142 determines whether or not to use the next slice for filter processing near the boundary, based on the supplied system specification information (hardware resources, usage purpose, etc.).", "That is to say, in the event that a pixel near a boundary with the neighboring slice being included in surrounding pixels is the pixel to be processed, the determining unit 142 determines whether to perform filter processing straddling slices, or to perform filter processing closed at the current slice.", "For example, in the event that increased delay time is tolerable, and there is sufficient memory capacity available at the image encoding device 100 and image decoding device and the like, the determining unit 142 selects filter processing straddling slices.", "Also, for example, in the event that increase in delay time is intolerable or there are not sufficient hardware resources in the devices of the system, the determining unit 142 selects filter processing closed at the current slice.", "In the event that determination has been made to use the next slice, i.e., to perform filter processing straddling slices, the flow advances to step S153.In step S153 the generating unit 143 generates a boundary control flag with a value “1”.", "Also, in the event that determination has been made not to use the next slice, i.e., to perform filter processing closed at the current slice, the flow advances to step S154.In step S154 the generating unit 143 generates a boundary control flag with a value “0”.", "Upon generating the boundary control flag, the generating unit 143 supplies this to the adaptive filter processing unit 113 and lossless encoding unit 106.The lossless encoding unit 106 encodes the boundary control flag supplied from the generating unit 143 as control information, and embeds this in the slice header or the like of the current slice.", "The adaptive filter processing unit 113 controls adaptive filter processing using the boundary control flag supplied from the generating unit 143.Upon the processing of step S153 or step S154 ending, the boundary control flag setting processing ends, the flow returns to step S132 in FIG.", "10, and processing of step S133 and on is performed.", "Next, an example of the flow of adaptive filter processing executed in step S111 in FIG.", "9 will be described with reference to the flowchart in FIG.", "12.Upon adaptive filter processing being started, in step S171 the buffer 181 obtains the decoded image of the slice to be processed from the deblocking filter 111.Upon the slice to be processed being obtained, in step S172 the control unit 171 identifies the region of the slice to be processed.", "In order to know the region of the current slice which is to be processed, this can be found by knowing the macroblocks included in the current slice, and knowing the pixels included in the macroblocks therefrom.", "The control unit 171 obtains the start macroblock address of the current slice from the slice header.", "Now, the start macroblock address is a number assigned to macroblocks in raster scan order from the upper left of the screen.", "As shown in FIG.", "5, the macroblock address at the upper left in the image (frame 151) is 0.Slice 0 is started from the upper left of the frame 151, so the macroblock address of the start macroblock 156-1 of the slice 0 is 0.Following this order, the end macroblock 156-2 or the slice 0 is E0.Also, in the same way as with this slice 0, the macroblock address of the start macroblock 157-1 of slice 1 is S1, and the macroblock address of the end macroblock 15721 is E1.Further, the macroblock address of the start macroblock 158-1 of slice 2 is S2, and the macroblock address of the end macroblock 158-2 is E2.As the current slice is decoded, one macroblock address is added each time decoding processing of one macroblock is completed, and eventually the end macroblock of the current slice is reached.", "A flag indicating the end macroblock of the slice is set at the end macroblock.", "Due to these, all macroblock addresses which the current slice holds can be known.", "That is to say, this is from the start macroblock address to the end macroblock address.", "Now, with a sequence parameter set (SPS (Sequence Parameter Set)) of an AVC stream (image compression information), the image size of one frame is indicated by the number of macroblocks.", "pic_height_in_map_units_minus1 indicates the number of macroblocks in the vertical direction of the image.", "pic_width_in_mbs_minus1 indicates the number of macroblocks in the horizontal direction of the image.", "Accordingly, from the macroblock address, the position of the macroblock is expressed by the following Expression (2) and Expression (3).", "mbx=macro block address % pic_width_in_mbs_minus1 (2) mby=floor[macro block address/pic_width_in_mbs_minus1] (3) In Expression (2) and Expression (3), mbx indicates which number from the left the macroblock is, and mby indicates what number from the top the macroblock is.", "Also, floor [z] indicates z being rounded out at the decimal so as to be an integer, and A % B indicates the remainder of having divided A with B.", "If we say that the size of the macroblock is determined to be 16×16 pixels, the vertical direction and horizontal direction position of the pixel at the upper left of the macroblock is (16×mbx, 16×mby), and the pixels included in the macroblock are pixels included in the range of 16 pixels to the lower direction and 16 pixels to the right direction form the upper left pixel position.", "Thus far, all pixels of the current slice can be known.", "That is to say, the region of the slice to be processed is identified.", "In step S173, the control unit 171 obtains one filter block flag generated at the control information generating unit 112.In step S174, the control unit 171 determines one of unprocessed ALF blocks to be the ALF block to be processed.", "The order of selection of ALF blocks is determined beforehand, and is in common with the selection order at the control information generating unit 112.Further, the control unit 171 identifies the region of the ALF block to be processed which has been decided.", "Since the image size of the frame is determined beforehand, upon the ALF block size being determined, the number of ALF blocks necessary to pave ALF blocks with the upper left of the frame as the point of origin (number of ALF blocks within the frame) can also be calculated.", "The setting values of the vertical direction size (number of pixels) and horizontal direction size (number of pixels) of the ALF blocks are provided beforehand, so the control unit 171 determines size of the ALF blocks and the number of ALF blocks following the setting values, and places the ALF blocks as to the decoded image.", "Note that the number of ALF blocks is calculated by the following Expression (4) and Expression (5).", "num_alf_block_x=floor[(16×(pic_width_in_mbs_minus1+1)+(alf_block_size−1))/alf_block_size] (4) num_alf_block_y=floor[(16×(pic_height_in_map_units_minus1+1)+(alf_block_size−1))/alf_block_size] (5) In Expression (4) and Expression (5), num_alf_block_x and num_alf_block_y are the number of horizontal and vertical ALF blocks included in the image, respectively.", "Also, alf_block_size represents the size of one side of an ALF block.", "To simplify description here, we will say that ALF blocks are squares.", "Of course, an arrangement may be made where the vertical direction size and horizontal direction size of the ALF blocks are different from each other.", "The position of the i'th ALF block is expressed by the following Expression (6) and Expression (7).", "alf_block_x=i % (num_alf_block_x−1) (6) alf_block_y=floor[i/(num_alf_block_x−1)] (7) In Expression (6) and Expression (7), alf_block_x and alf_block_y each indicate what number in the horizontal direction and vertical direction the i'th ALF block is.", "The position of the upper left pixel of the i'th ALF block is a position obtained by multiplying each of alf_block_x and alf_block_y by the alf_block_size.", "That is to say, the horizontal direction is 16×alf_block_x, and the vertical direction is 16×alf_block_y.", "Accordingly, the region of the i'th ALF block is a range of alf_block_size×alf_block_size from the upper left pixel thereof.", "In step S175, the control unit 171 determines whether or not a region of the slice to be processed is included within the region of the ALF block to be processed which ha been identified as described above.", "In the event that determination is made that the region of the slice to be processed is included, the flow advances to step S176.In step S176, the control unit 171 determines whether or not the value of the filter block flag is 1.In the event that the value of the filter block flag is 1, and instruction has been given to perform filter processing regarding the ALF block to be processed, control is effected such that the selecting unit 173 selects the output of the filter 172, and the flow advances to step S177.In step S177, the control unit 171 selects the pixels to be processed in a predetermined order such as, for example, in raster scan order or the like, from unprocessed pixels.", "In step S178, The control unit 171 determines whether or not pixels of the neighboring slice are necessary for filter processing of the selected pixel to be processed.", "In the event that pixels of the neighboring slice are included in the surrounding pixels of the pixel to be processed, and determination is made that the pixel to be processed is a pixel near the slice boundary, the flow advances to step S179.In step S179, the control unit 171 determines whether or not the value of the boundary control value included in the control information obtained by the control information generating unit 112 is “1”.", "In the event that determination is made that the value of the boundary control flag is “1”, the flow advances to step S180.In step S180, the control unit 171 selects first adaptive filter for boundary 183 as the adaptive filter, and causes the first adaptive filter for boundary 183 to perform filter processing straddling slices as shown in A in FIG.", "7.Upon the processing of step S180 ending, the flow advances to step S183.Also, in step S179, in the event that determination is made that the value of the boundary control flag is “0”, the flow advances to step S181.In step S181, the control unit 171 selects the second adaptive filter for boundary 184 as the adaptive filter, and causes the second adaptive filter for boundary 184 to perform filter processing closed at the current slice as shown in B in FIG.", "7.Upon the processing of step S181 ending, the flow advances to step S183.Also, in the event that determination is made in step S178 that the pixel to be processed is not a pixel near a slice boundary, the flow advances to step S182.In step S182, the control unit 171 selects the in-slice adaptive filter 182 as the adaptive filter, and causes the in-slice adaptive filter 182 to perform normal filter processing using only pixels of the current slice.", "Upon the processing in step S182 ending, the flow advances to step S183.Also, in the event that determination is made in step S176 that the value of the filter block flag is “02, the flow advances to step S183.Further, in the event that determination is made in step S175 that the ALF block to be processed does not include the region of the slice to be processed, the flow advances to step S183.In step S183, the control unit 171 determines whether all pixels within the ALF block to be processed have been processed.", "In the event that determination is made that an unprocessed pixel exists, the flow returns to step S177 and the subsequent processing is repeated.", "Also, in the event that determination is made in step S183 that all pixels within the ALF block to be processed have been processed, the flow advances to step S184.In step S184, the control unit 171 determines whether all ALF blocks within the frame have been processed.", "In the event that determination is made that an unprocessed ALF block exists, the flow returns to step S173 and the subsequent processing is repeated.", "Also, in the event that determination is made in step S184 that all ALF blocks have been processed, adaptive filter control processing is ended, the flow returns to step S111 in FIG.", "9, and the processing of step S122 and on is performed.", "Note that the filter processing as to the pixels to be processed, performed in step S180 through step S182 are each executed independently as different tasks from the adaptive filter control processing.", "That is to say, in step S180 through step S182, upon executing of adaptive filter processing being specified, the adaptive filter processing is executed as appropriate.", "That is to say, these adaptive filter processing are executable in parallel with the adaptive filter control processing and adaptive filter processing as to other pixels.", "These filter processing will be described with reference to the flowchart in FIG.", "13 and FIG.", "14.First, an example of the flow of filter processing executed by the first adaptive filter for boundary 183 will be described with reference to the flowchart in FIG.", "13.Upon execution is instructed for filter processing straddling slices, of which execution is instructed in step S180 in FIG.", "12, in step S201 the first adaptive filter for boundary 183 monitors the buffer 181, determines whether or not all pixels of the surrounding region of the pixel to be processed are accumulated, and stands by until accumulated.", "Pixels of the surrounding region (i.e., surrounding pixels) include pixels of the neighboring slice as well.", "In the event that determination is made that all the pixels have been accumulated in the buffer 181, the flow advances to step S202.In step S202, the first adaptive filter for boundary 183 obtains pixels of the surrounding region (surrounding pixels) from the buffer 181 and in step S203 uses the surrounding pixels and the filter coefficient set at the control unit 171 to perform filter processing of the pixel to be processed.", "Upon filter processing ending, the first adaptive filter for boundary 183 supplies the filter processing results to the selecting unit 173, and filter processing ends.", "In the event that the value of the filter block flag is “1”, the selecting unit 173 selects the filter processing results, and supplies to the frame memory 114 as the decoded image subjected to filtering processing, so as to be stored.", "Next, an example of the flow of filter processing executed by the second adaptive filter for boundary 184 will be described with reference to the flowchart in FIG.", "14.Upon execution is instructed to filter processing closed at the current slice, of which execution is instructed in step S181 in FIG.", "12, in step S221 the second adaptive filter for boundary 184 duplicates surrounding pixels situated in the current slice already held in the buffer 181, and generates dummy data of the surrounding pixels situated in the neighboring slice.", "Upon generating dummy data, in step S212 the second adaptive filter for boundary 184 uses the surrounding pixels including the dummy data and the filter coefficient set at the control unit 171 to perform filter processing of the pixel to be processed.", "Upon the filter processing ending, the second adaptive filter for boundary 184 supplies the filter processing results to the selecting unit 173 and the filter processing ends.", "In the event that the value of the filter block flag is “1”, the selecting unit 173 selects these filter processing results, and supply to the frame memory 114 as the decoded image subjected to filter processing, so as to be stored.", "As described above, based on the value of the boundary control flag, the method for filter processing as a pixel near a boundary is selected as appropriate from multiple methods, whereby the adaptive filter processing unit 113 can suppress deterioration in the effects of filter processing due to local control of filter processing when encoding.", "For example, by performing filter processing so as to straddle slices, the adaptive filter processing unit 113 can improve the image quality of the filter processing.", "Also, by performing filter processing closed at the current slice, the adaptive filter processing unit 113 can perform filter processing with low delay.", "At this time, the adaptive filter processing unit 113 selects the filter processing method based on the boundary control flag determined based on system specification information, so filter processing can be performed without breakdown of processing.", "Also, the boundary control flag generating unit 132 sets a boundary flag based on the system specification information, whereby the adaptive filter processing unit 113 can be caused to execute filter processing so as to suppress deterioration of effects.", "That is to say, the image encoding device 100 can suppress deterioration in the effects of filter processing due to local control of filter processing when encoding.", "Note that the lossless encoding unit 106 encodes the boundary control flag and adds to the image compression information (embeds in the slice header, for example).", "Accordingly, the image encoding device 100 can cause an image decoding device which decodes the image compression information output by the image encoding device 100 to suppress deterioration in the effects of filter processing due to local control of filter processing performed when decoding.", "Now, to “add” means to correlate the boundary control flag to the image compression information with an optional form.", "For example, this may be described as a syntax of the image compression information, or may be describe as user data.", "Also, the boundary control flag may be in a state linked with the image compression information as metadata.", "That is to say, to “add” includes “embedding”, “description”, “multiplexing”, “linking”, and so forth.", "Also, with the above, description has been made to perform filter processing straddling slices or filter processing closed at the current slice, as to pixels near the slice boundary, but filter processing may be performed with other methods as well.", "Also, instead of performing filter processing closed at the current slice, the filter processing may be omitted, for example.", "Further, it is sufficient for multiple filter processing methods for a pixel near a slice boundary to have been prepared, and three or more methods may be prepared as options.", "In this case, two bits or more are necessary for the boundary control flag.", "Note that the number of bits of the boundary control flag is optional.", "However, the fewer the number of bits are, the more the deterioration of encoding efficiency of the image compression information is suppressed, so unnecessarily increasing the number of bits is undesirable.", "2.Second Embodiment [Configuration of Device] Next, an image decoding device corresponding to the image encoding device 100 described with the first embodiment will be described.", "FIG.", "15 is a block diagram illustrating the configuration of an embodiment of an image decoding device serving as an image processing device to which the present invention has been applied.", "An image decoding device 200 decodes image compression information output from the image encoding device 100, and generates a decoded image.", "An image decoding device 200 is configured of a storing buffer 201, a lossless decoding unit 202, an inverse quantization unit 203, an inverse orthogonal transform unit 204, a computing unit 205, and a deblocking filter 206.the image decoding device 200 also has an adaptive filter processing unit 207.The image decoding device 200 further has a screen rearranging buffer 208 and a D/A (Digital/Analog) conversion unit 209.The image decoding device 200 also has frame memory 210, an intra prediction unit 211, a motion compensation unit 212, and a selecting unit 213.The storing buffer 201 stores a transmitted compressed image information.", "The lossless decoding unit 202 decodes information supplied from the storing buffer 201 and encoded by the lossless encoding unit 106 in FIG.", "1 using a format corresponding to the encoding format of the lossless encoding unit 106.In the event that the current macroblock has been intra encoded, the lossless decoding unit 202 decodes the intra prediction mode information stored in the header portion of the image compression information, and transmits this information to the intra prediction unit 211.Also, in the event that the current macroblock has been inter encoded, the lossless decoding unit 202 decodes the motion vector information stored in the header portion of the image compression information, and transmits the information thereof to the motion compensation unit 212.Also, the lossless decoding unit 202 extracts control information for the adaptive filter (control information generated by the control information generating unit 112) from the slice header of the image compression information, and decodes, and supplies the information thereof to the adaptive filter processing unit 207.The inverse quantization unit 203 subjects the image decoded by the lossless decoding unit 202 to inverse quantization using a format corresponding to the quantization format of the quantization unit 105 in FIG.", "1.The inverse orthogonal transform unit 204 subjects the output of the inverse quantization unit 203 to inverse orthogonal transform using a format corresponding to the orthogonal transform format of the orthogonal transform unit 104 in FIG.", "1.The computing unit 205 adds the prediction image supplied from the selecting unit 213 to the difference information subjected to inverse orthogonal transform, and generates a decoded image.", "The deblocking filter 206 removes the block noise of the decoded image which has been generated by the adding processing.", "The adaptive filter processing unit 207 performs filter processing on the image supplied from the deblocking filter 206 based on the filter coefficient, ALF block size, filter block flag, and boundary control flag and the like, supplied from the lossless encoding unit.", "The adaptive filter processing unit 207 performs adaptive filter processing in the same way as with the adaptive filter processing unit 113 in FIG.", "1.Accordingly, the adaptive filter processing unit 207 can reduce block noise and noise due to quantization which could not be completely removed with the deblocking filter 206.The adaptive filter processing unit 207 supplies the image following filter processing to the frame memory 210 so as to be stored as reference image information, and also outputs to the screen rearranging buffer 208.The screen rearranging buffer 208 performs rearranging of images.", "That is to say, the order of frames rearranged for encoding by the screen rearranging buffer 102 in FIG.", "1 is rearranged to the original display order.", "The D/A conversion unit 209 performs D/A conversion of the image supplied from the screen rearranging buffer 208, and outputs.", "For example, the D/A conversion unit 209 outputs the output signals obtained by performing D/A conversion to an unshown display, and displays an image.", "The intra prediction unit 211 generates a prediction image based on the information supplied from the lossless decoding unit 202 in the event that the current frame has been intra encoded, and outputs the generated prediction image to the selecting unit 213.In the event that the current frame has been intra encoded, the motion compensation unit 212 performs motion compensation processing as to the reference image information stored in the frame memory 210, based on the motion vector information supplied from the lossless decoding unit 202.In the event that the current macroblock has been intra encoded, the selecting unit 213 connects to the intra prediction unit 211, and supplies the image supplied from the intra prediction unit 211 to the computing unit 205 as a prediction image.", "Also, in the event that the current macroblock has been inter encoded, the selecting unit 213 connects to the motion compensation unit 212 and supplies the image supplied from the motion compensation unit 212 to the computing unit 205 as a prediction image.", "[Flow of Processing] An example of the flow of decoding processing which this image decoding device 200 executes will be described with reference to the flowchart in FIG.", "16.In step S301, the storing buffer 201 stores the transmitted image.", "In step S302, the lossless decoding unit 202 extracts the control information for adaptive filter processing from the slice header of the image compression information, and decodes this in step S303.The decoded control information is supplied to the adaptive filter processing unit 207.Also, in step S303, the lossless decoding unit 202 decodes the compressed image supplied from the storing buffer 201.Specifically, the I picture, P picture, and B picture encoded by the lossless encoding unit 106 in FIG.", "1 are decoded.", "At this time, the motion vector information, reference frame information, prediction mode information (information indicating the intra prediction mode or inter prediction mode), and so forth are also decoded.", "Specifically, in the event that the prediction mode information is intra prediction mode information, the prediction mode information is supplied to the intra prediction unit 211.In the event that the prediction mode information is inter prediction mode information, motion vector information and reference frame information corresponding to the prediction mode information are supplied to the motion compensation unit 212.In step S304, the inverse quantization unit 203 inversely quantizes the transform coefficient decoded in step S302 using a property corresponding to the property of the quantization unit 105 in FIG.", "1.In step S305, the inverse orthogonal transform unit 204 subjects the transform coefficient inversely quantized in step S204 to inverse orthogonal transform using a property corresponding to the property of the orthogonal transform unit 104 in FIG.", "1.This means that difference information corresponding to the input of the orthogonal transform unit 104 in FIG.", "1 (the output of the computing unit 103) has been decoded.", "In step S306, the computing unit 205 adds the prediction image selected in the processing in later-described step S212 to the difference information.", "Thus, the original image is decoded.", "In step S307, the deblocking filter 206 subjects the image output from the computing unit 205 to filtering.", "Thus, block noise is removed.", "In step S308, the adaptive filter processing unit 207 performs adaptive filter control processing for subjecting the image, subjected to deblocking filter processing, further to adaptive filter processing.", "This adaptive filter control processing is the same as the processing which the adaptive filter processing unit 113 in FIG.", "1 performs.", "That is to say, this adaptive filter control processing is the same as the case described with reference to the flowchart in FIG.", "12, other than using the control information supplied from the lossless decoding unit 202.Note however, the control information supplied from this lossless decoding unit 202 has been generated by the control information generating unit 112 in FIG.", "1, and is substantially equivalent to the control information supplied from the control information generating unit 112 which the adaptive filter processing unit 113 in FIG.", "1 uses.", "Due to this adaptive filter control processing, block noise and noise due to quantization which could not be completely removed with the deblocking filter processing can be reduced.", "In step S309, the frame memory 210 stores the image subjected to filtering.", "In the event that intra prediction mode information has been supplied, in step S310 the intra prediction unit 211 performs intra prediction processing in the intra prediction mode.", "Also, in the event that inter prediction mode information has been supplied, in step S311 the motion compensation unit 212 performs motion compensation processing in the intra prediction mode.", "In step S312, the selecting unit 213 selects a prediction image.", "That is to say, one of the prediction image generated by the intra prediction unit 211 and the prediction image generated by the motion compensation unit 212 is selected, and the selected prediction image is supplied to the computing unit 205.For example, in the event of an image which has been intra encoded, the selecting unit 213 selects a prediction image generated by the intra prediction unit 211 and supplies this to the computing unit 205.Also, in the event of an image which as been inter encoded, the selecting unit 213 selects a prediction image generated by the motion compensation unit 212 and supplies this to the computing unit 205.In step S313, the screen rearranging buffer 208 performs rearranging.", "Specifically, the sequence of frames rearranged for encoding by the screen rearranging buffer 102 of the image encoding device 100 is rearranged to the original display sequence.", "In step S314, the D/A conversion unit 209 performs D/A conversion of the image from the screen rearranging buffer 208.This image is output to an unshown display, and the image is displayed.", "Thus, with the image decoding unit 200, the lossless decoding unit 202 extracts control information supplied from the image encoding device 100 and decodes, and the adaptive filter processing unit 207 performs adaptive filter control processing (and filter processing) the same as with the adaptive filter processing unit 113 of the image encoding device 100, using this control information.", "By performing such adaptive filter control processing, the adaptive filter processing unit 207 can suppress deterioration in the effects of filter processing due to local control of filter processing performed when decoding.", "Accordingly, the image decoding device 200 can suppress deterioration in the effects of filter processing due to local control of filter processing performed when decoding.", "3.Third Embodiment [Image Processing System] Note that while description has been made above that the system specification managing unit 141 of the control information generating unit 112 holds or corrects system specification information, the system specification information may be made to include specification information of the image decoding device.", "In this case, in the event that the specification information of the image decoding device is not known beforehand, the image encoding device needs to collect the specification information of the image decoding device at a predetermined time, such as at the time of connecting communicably between the image encoding device and image decoding device, for example.", "At this time, the image encoding device may perform communication with the image decoding to obtain the specification information from the image decoding device, or specification input by the user, for example, may be obtained.", "Now, an unshown image processing system is a system where an image encoding device 300 shown in FIG.", "17 and an image decoding device 400 shown in FIG.", "18 are communicably connected via a communication medium such as a network.", "The following is a description of the configuration of the devices.", "FIG.", "17 is a block diagram illustrating another example of an image encoding device serving as an image processing device to which the present invention has been applied.", "The image encoding device 300 is basically the same device as the image encoding device 100 in FIG.", "1, and has an image encoding unit 301.The configuration of the image encoding unit 301 is the same as the configuration of the image encoding device 100, having the A/D conversion unit 101 through rate control unit 119, and operates in the same way as with the case described with the first embodiment.", "Besides the image encoding unit 301, the image encoding device 300 further has an input unit 302, communication unit 303, and information collecting unit.", "The input unit 302 accepts operations of the user and the like.", "The communication unit 303 performs communication with the image decoding device 400 via a network or the like.", "The information collecting unit 304 collects specification information of the image decoding device 400 input via the input unit 302 or specification information supplied from the image decoding device 400 via the communication unit 303.The information collecting unit 304 supplies the collected specification information to the system specification managing unit 141 of the control information generating unit 112.FIG.", "18 is a block diagram illustrating another example of an image decoding device serving as an image processing device to which the present invention has been applied.", "The image decoding device 400 is basically the same device as the image decoding device 200 in FIG.", "15, and has an image decoding unit 401.The configuration of the image decoding unit 401 is the same as the configuration of the image decoding device 200, having the storing buffer 201 through selecting unit 213, and operates in the same way as with the case described with the second embodiment.", "Besides the image decoding unit 401, the image decoding device 400 further has an information providing unit 402 and communication unit 403.The information providing unit 402 has specification information of the image decoding device 400, and based on a request from the image encoding device 300, provides the specification information.", "The communication unit 403 performs communication with the image encoding device 300 via a network or the like.", "The communication unit 403 accepts a request from the image encoding device 300, and supplies this to the information providing unit 402.the communication unit 403 also supplies the specification information of the image decoding device 400 supplied from the information providing unit 402 in accordance with the request to the image encoding device 300.", "[Flow of Processing] An example of the flow of exchange of specification information with such an image processing system will be described with reference to the flowchart in FIG.", "19.In step S401, the information collecting unit 304 of the image encoding device 300 requests the image decoding device 400 for specification information of the image decoding device 400 via the communication unit 303.Upon receiving the request in step S421, the communication unit 403 of the image decoding device 400 supplies the request to the information providing unit 402.In step S422, the information providing unit 402 supplies the specification information of the image decoding device 400 to the requesting image encoding device 300 via the communication unit 403, as a response to the request.", "Upon obtaining the specification information in step S402 via the communication unit 303, the information collecting unit 304 of the image encoding device 300 supplies this to the system specification managing unit 141 of the control information generating unit 112.In step S403, the image encoding unit 301 performs encoding processing based on the specification information, and generates a code stream.", "In step S404, the image encoding unit 301 supplies the generated code stream to the image decoding device 400.In step S423, the image decoding unit 401 of the image decoding device 400 obtains the code stream supplied from the image encoding device 300.In step S424, the image decoding unit 401 performs decoding processing as to the code stream.", "Thus, specification information of the image decoding device 400 is exchanged before image encoding processing and image decoding processing, so the image encoding device 300 can create boundary control flags based on the system specification information including the specification information of the image decoding device 400.Accordingly, the image encoding device 300 and the image decoding device 400 can suppress deterioration in the effects of filter processing due to local control of filter processing performed when encoding or decoding, as described with the first embodiment and second embodiment.", "4.Fourth Embodiment [Description of QALF] ALF blocks may have a quad tree structure, as described with NPL 3.This technique is called QALF (Quad tree-based Adaptive Loop Filter).", "A quad tree structure is a hierarchical structure where, at a lower hierarchical level, the region of one ALF block one hierarchical level above is divided into four.", "FIG.", "20 illustrates an example where ALF block division is expressed by a quad tree structure where the maximum number of layers is three, with a filter block flag being specified for each ALF block.", "A in FIG.", "20 indicates a layer 0 which is an ALF block serving as the root of the quad tree structure.", "In the quad tree structure, each ALF block has a block partitioning flag indicating whether or not it is divided into four at the lower hierarchical level.", "The value of the block partitioning flag of the ALF block shown in A in FIG.", "20 is “1”.", "That is to say, this ALF block is divided into four in the lower hierarchical level (layer 1).", "B in FIG.", "20 shows the layer 1.That is to say, four ALF blocks are formed in the layer 1.In the event that the block partitioning flag is “0”, a further lower hierarchical level is not divided into four.", "That is to say, there is no further division, and a filter block flag is generated as to that ALF block.", "That is to say, an ALF block of which the block partitioning flag is “0” also has a filter block flag.", "The “0” to the left of the “0-1” shown in B in FIG.", "20 indicates the block partitioning flag of that ALF block, and the “1” to the right shows the filter block flag of that ALF block.", "The two ALF blocks of which the block partitioning flag in layer 1 is “1” are divided into four in the lower hierarchical level (layer 2).", "C in FIG.", "20 illustrates the layer 2.That is to say, ten ALF blocks are formed in layer 2.In the same way, ALF blocks with the block partitioning flag of “0” in layer 2 are also assigned a filter block flag.", "In C in FIG.", "20, the block partitioning flag of one ALF block is “1”.", "That is to say, that ALF block is divided into four in the further lower hierarchical level (layer 3).", "D in FIG.", "20 show the layer 3.That is to say, 13 ALF blocks are formed in the layer 3.By forming a quad tree as shown in FIG.", "20, the structure of the ALF block ultimately becomes as shown in FIG.", "21.Thus, with a quad tree structure, the size of ALF blocks differs with each hierarchical level.", "That is to say, by using a quad tree structure, the sizes of the ALF blocks can be made to be different one from another within the frame.", "Control of the filter block flag in each ALF block is the same as with the other embodiments described above.", "That is to say, filter processing is not performed in regions where the value of the filter block flag is “0” (the hatched portions in FIG.", "21).", "FIG.", "22 illustrates an example of encoding the region of slice 1 in FIG.", "5 using the QALF technique.", "Here, the region of the heavy line 521 represents the region of slice 1.Regardless of the ALF structure, there may be cases where the surrounding pixels straddle multiple slices when performing filter processing on pixels near a slice boundary.", "Accordingly, the control method of filter processing as to pixels near a slice boundary can be performed in the same way as with the above-described embodiments for the case of QALF as well.", "That is to say, even with a case of quad tree structure ALF blocks, the image encoding device and image decoding device can suppress deterioration in the effects of filter processing due to local control of filter processing performed when encoding or decoding.", "5.Fifth Embodiment [Personal Computer] The above-described series of processing may be executed by hardware, and may be executed by software.", "In this case, a configuration may be made as a personal computer such as shown in FIG.", "23, for example.", "In FIG.", "23, a CPU 601 of a personal computer 600 executes various types of processing following programs stored in ROM (Read Only Memory) 602 or programs loaded to RAM (Random Access Memory) 603 from a storage unit 613.The RAM 603 also stores data and so forth necessary for the CPU 601 to execute various types of processing, as appropriate.", "The CPU 601, ROM 602, and RAM 603 are mutually connected by a bus 604.This bus 604 is also connected to an input/output interface 610.Connected to the input/output interface 610 is an input unit 611 made up of a keyboard, a mouse, and so forth, an output unit 612 made up of a display such as a CRT (Cathode Ray Tube) or LCD (Liquid Crystal Display) or the like, a speaker, and so forth, a storage unit 613 made up of a hard disk and so forth, and a communication unit 614 made up of a modem and so forth.", "The communication unit 614 performs communication processing via networks including the Internet.", "Also connected to the input/output interface 610 is a drive 615 as necessary, to which a removable medium 621 such as a magnetic disk, an optical disc, a magneto-optical disk, semiconductor memory, or the like, is mounted as appropriate, and computer programs read out therefrom are installed in the storage unit 613 as necessary.", "In the event of executing the above-described series of processing by software, a program configuring the software is installed from a network or recording medium.", "This recording medium is not only configured of a removable medium 621 made up of a magnetic disk (including flexible disk), optical disc (including CD-ROM (Compact Disc-Read Only Memory), DVD (Digital Versatile Disc), magneto-optical disc (MD (Mini Disc)), or semiconductor memory or the like, in which programs are recorded and distributed so as to distribute programs to users separately from the device main unit, but also is configured of ROM 602, a hard disk included in the storage unit 613, and so forth, in which programs are recorded, distributed to users in a state of having been built into the device main unit beforehand.", "Note that a program which the computer executes may be a program in which processing is performed in time sequence following the order described in the present Specification, or may be a program in which processing is performed in parallel, or at a necessary timing, such as when a call-up has been performed.", "Also, with the present Specification, steps describing programs recorded in the recording medium includes processing performed in time sequence following the described order as a matter of course, and also processing executed in parallel or individually, without necessarily being processed in time sequence.", "Also, with the present specification, the term system represents the entirety of devices configured of multiple devices (devices).", "Also, a configuration which has been described above as one device (or processing unit) may be divided and configured as multiple devices (or processing units).", "Conversely, configurations which have been described above as multiple devices (or processing units) may be integrated and configured as a single device (or processing unit).", "Also, configurations other than those described above may be added to the devices (or processing units), as a matter of course.", "Further, part of a configuration of a certain device (or processing unit) may be included in a configuration of another device (or another processing unit), as long as the configuration and operations of the overall system is substantially the same.", "That is to say, the embodiments of the present invention are not restricted to the above-described embodiments, and that various modifications may be made without departing from the essence of the present invention.", "For example, the above-described image encoding device 100, image decoding device 200, encoding device 300, and image decoding device 400 may be applied to image various electronic devices.", "The following is a description of examples thereof.", "6.Sixth Embodiment [Television Receiver] FIG.", "24 is a block diagram illustrating a principal configuration example of a television receiver using the image decoding device 200 or image decoding device 400 to which the present invention has been applied.", "A television receiver 1000 shown in FIG.", "24 includes a terrestrial tuner 1013, a video decoder 1015, a video signal processing circuit 1018, a graphics generating circuit 1019, a panel driving circuit 1020, and a display panel 1021.The terrestrial tuner 1013 receives the broadcast wave signals of a terrestrial analog broadcast via an antenna, demodulates, obtains video signals, and supplies these to the video decoder 1015.The video decoder 1015 subjects the video signals supplied from the terrestrial tuner 1013 to decoding processing, and supplies the obtained digital component signals to the video signal processing circuit 1018.The video signal processing circuit 1018 subjects the video data supplied from the video decoder 1015 to predetermined processing such as noise removal or the like, and supplies the obtained video data to the graphics generating circuit 1019.The graphics generating circuit 1019 generates the video data of a program to be displayed on a display panel 1021, or image data due to processing based on an application to be supplied via a network, or the like, and supplies the generated video data or image data to the panel driving circuit 1020.Also, the graphics generating circuit 1019 also performs processing such as supplying video data obtained by generating video data (graphics) for the user displaying a screen used for selection of an item or the like, and superimposing this on the video data of a program, to the panel driving circuit 1020 as appropriate.", "The panel driving circuit 1020 drives the display panel 1021 based on the data supplied from the graphics generating circuit 1019 to display the video of a program, or the above-mentioned various screens on the display panel 1021.The display panel 1021 is made up of an LCD (Liquid Crystal Display) and so forth, and displays the video of a program or the like in accordance with the control by the panel driving circuit 1020.Also, the television receiver 1000 also includes an audio A/D (Analog/Digital) conversion circuit 1014, an audio signal processing circuit 1022, an echo cancellation/audio synthesizing circuit 1023, an audio amplifier circuit 1024, and a speaker 1025.The terrestrial tuner 1013 demodulates the received broadcast wave signal, thereby obtaining not only a video signal but also an audio signal.", "The terrestrial tuner 1013 supplies the obtained audio signal to the audio A/D conversion circuit 1014.The audio A/D conversion circuit 1014 subjects the audio signal supplied from the terrestrial tuner 1013 to A/D conversion processing, and supplies the obtained digital audio signal to the audio signal processing circuit 1022.The audio signal processing circuit 1022 subjects the audio data supplied from the audio A/D conversion circuit 1014 to predetermined processing such as noise removal or the like, and supplies the obtained audio data to the echo cancellation/audio synthesizing circuit 1023.The echo cancellation/audio synthesizing circuit 1023 supplies the audio data supplied from the audio signal processing circuit 1022 to the audio amplifier circuit 1024.The audio amplifier circuit 1024 subjects the audio data supplied from the echo cancellation/audio synthesizing circuit 1023 to D/A conversion processing, subjects to amplifier processing to adjust to predetermined volume, and then outputs the audio from the speaker 1025.Further, the television receiver 1000 also includes a digital tuner 1016, and an MPEG decoder 1017.The digital tuner 1016 receives the broadcast wave signals of a digital broadcast (terrestrial digital broadcast, BS (Broadcasting Satellite)/CS (Communications Satellite) digital broadcast) via the antenna, demodulates to obtain MPEG-TS (Moving Picture Experts Group-Transport Stream), and supplies this to the MPEG decoder 1017.The MPEG decoder 1017 descrambles the scrambling given to the MPEG-TS supplied from the digital tuner 1016, and extracts a stream including the data of a program serving as a playback object (viewing object).", "The MPEG decoder 1017 decodes an audio packet making up the extracted stream, supplies the obtained audio data to the audio signal processing circuit 1022, and also decodes a video packet making up the stream, and supplies the obtained video data to the video signal processing circuit 1018.Also, the MPEG decoder 1017 supplies EPG (Electronic Program Guide) data extracted from the MPEG-TS to a CPU 1032 via an unshown path.", "The television receiver 1000 uses the above-mentioned image decoding device 200 or image decoding device 400 as the MPEG decoder 1017 for decoding video packets in this way.", "Note that the MPEG-TS transmitted from the broadcasting station or the like has been encoded by the image encoding device 100 or image encoding device 300.The MPEG decoder 1017 extracts and decodes control information supplied from the image encoding device 100 or image encoding device 300, in the same way as with the image decoding device 200 or image decoding device 400, and performs adaptive filter control processing (and filter processing) using this control information.", "Accordingly, the MPEG decoder 1017 can suppress deterioration in the effects of local control of filter processing.", "The video data supplied from the MPEG decoder 1017 is, in the same way as with the case of the video data supplied from the video decoder 1015, subjected to predetermined processing at the video signal processing circuit 1018, superimposed on the generated video data and so forth at the graphics generating circuit 1019 as appropriate, supplied to the display panel 1021 via the panel driving circuit 1020, and the image thereof is displayed thereon.", "The audio data supplied from the MPEG decoder 1017 is, in the same way as with the case of the audio data supplied from the audio A/D conversion circuit 1014, subjected to predetermined processing at the audio signal processing circuit 1022, supplied to the audio amplifier circuit 1024 via the echo cancellation/audio synthesizing circuit 1023, and subjected to D/A conversion processing and amplifier processing.", "As a result thereof, the audio adjusted in predetermined volume is output from the speaker 1025.Also, the television receiver 1000 also includes a microphone 1026, and an A/D conversion circuit 1027.The A/D conversion circuit 1027 receives the user's audio signals collected by the microphone 1026 provided to the television receiver 1000 serving as for audio conversation, subjects the received audio signal to A/D conversion processing, and supplies the obtained digital audio data to the echo cancellation/audio synthesizing circuit 1023.In the event that the user (user A)'s audio data of the television receiver 1000 has been supplied from the A/D conversion circuit 1027, the echo cancellation/audio synthesizing circuit 1023 perform echo cancellation with the user (user A)'s audio data taken as a object, and outputs audio data obtained by synthesizing the user A's audio data and other audio data, or the like from the speaker 1025 via the audio amplifier circuit 1024.Further, the television receiver 1000 also includes an audio codec 1028, an internal bus 1029, SDRAM (Synchronous Dynamic Random Access Memory) 1030, flash memory 1031, a CPU 1032, a USB (Universal Serial Bus) I/F 1033, and a network I/F 1034.The A/D conversion circuit 1027 receives the user's audio signal collected by the microphone 1026 provided to the television receiver 1000 serving as for audio conversation, subjects the received audio signal to A/D conversion processing, and supplies the obtained digital audio data to the audio codec 1028.The audio codec 1028 converts the audio data supplied from the A/D conversion circuit 1027 into the data of a predetermined format for transmission via a network, and supplies to the network I/F 1034 via the internal bus 1029.The network I/F 1034 is connected to the network via a cable mounted on a network terminal 1035.The network I/F 1034 transmits the audio data supplied from the audio codec 1028 to another device connected to the network thereof, for example.", "Also, the network I/F 1034 receives, via the network terminal 1035, the audio data transmitted from another device connected thereto via the network, and supplies this to the audio codec 1028 via the internal bus 1029, for example.", "The audio codec 1028 converts the audio data supplied from the network I/F 1034 into the data of a predetermined format, and supplies this to the echo cancellation/audio synthesizing circuit 1023.The echo cancellation/audio synthesizing circuit 1023 performs echo cancellation with the audio data supplied from the audio codec 1028 taken as a object, and outputs the data of audio obtained by synthesizing the audio data and other audio data, or the like, from the speaker 1025 via the audio amplifier circuit 1024.The SDRAM 1030 stores various types of data necessary for the CPU 1032 performing processing.", "The flash memory 1031 stores a program to be executed by the CPU 1032.The program stored in the flash memory 1031 is read out by the CPU 1032 at predetermined timing such as when activating the television receiver 1000, or the like.", "EPG data obtained via a digital broadcast, data obtained from a predetermined server via the network, and so forth are also stored in the flash memory 1031.For example, MPEG-TS including the content data obtained from a predetermined server via the network by the control of the CPU 1032 is stored in the flash memory 1031.The flash memory 1031 supplies the MPEG-TS thereof to the MPEG decoder 1017 via the internal bus 1029 by the control of the CPU 1032, for example.", "The MPEG decoder 1017 processes the MPEG-TS thereof in the same way as with the case of the MPEG-TS supplied from the digital tuner 1016.In this way, the television receiver 1000 receives the content data made up of video, audio, and so forth via the network, decodes using the MPEG decoder 1017, whereby video thereof can be displayed, and audio thereof can be output.", "Also, the television receiver 1000 also includes a light reception unit 1037 for receiving the infrared signal transmitted from a remote controller 1051.The light reception unit 1037 receives infrared rays from the remote controller 1051, and outputs a control code representing the content of the user's operation obtained by demodulation, to the CPU 1032.The CPU 1032 executes the program stored in the flash memory 1031 to control the entire operation of the television receiver 1000 according to the control code supplied from the light reception unit 1037, and so forth.", "The CPU 1032, and the units of the television receiver 1000 are connected via an unshown path.", "The USB I/F 1033 performs transmission/reception of data as to an external device of the television receiver 1000 which is connected via a USB cable mounted on a USB terminal 1036.The network I/F 1034 connects to the network via a cable mounted on the network terminal 1035, also performs transmission/reception of data other than audio data as to various devices connected to the network.", "The television receiver 1000 uses the image decoding device 200 or image decoding device 400 as the MPEG decoder 1017, whereby deterioration in the effects of local control of filter processing as to broadcast signals received via an antenna or content data obtained via a network can be suppressed.", "7.Seventh Embodiment [Cellular Telephone] FIG.", "25 is a block diagram illustrating a principal configuration example of a cellular telephone using the image encoding device and image decoding device to which the present invention has been applied.", "A cellular telephone 1100 shown in FIG.", "25 includes a main control unit 1150 configured so as to integrally control the units, a power supply circuit unit 1151, an operation input control unit 1152, an image encoder 1153, a camera I/F unit 1154, an LCD control unit 1155, an image decoder 1156, a multiplexing/separating unit 1157, a recording/playback unit 1162, a modulation/demodulation circuit unit 1158, and an audio codec 1159.These are mutually connected via a bus 1160.Also, the cellular telephone 1100 includes operation keys 1119, a CCD (Charge Coupled Devices) camera 1116, a liquid crystal display 1118, a storage unit 1123, a transmission/reception circuit unit 1163, an antenna 1114, a microphone (MIC) 1121, and a speaker 1117.Upon a call end and power key being turned on by the user's operation, the power supply circuit unit 1151 activates the cellular telephone 1100 in an operational state by supplying power to the units from a battery pack.", "The cellular telephone 1100 performs various operations, such as transmission/reception of an audio signal, transmission/reception of an e-mail and image data, image shooting, data recoding, and so forth, in various modes such as a voice call mode, a data communication mode, and so forth, based on the control of the main control unit 1150 made up of a CPU, ROM, RAM, and so forth.", "For example, in the voice call mode, the cellular telephone 1100 converts the audio signal collected by the microphone (mike) 1121 into digital audio data by the audio codec 1159, subjects this to spectrum spread processing at the modulation/demodulation circuit unit 1158, and subjects this to digital/analog conversion processing and frequency conversion processing at the transmission/reception circuit unit 1163.The cellular telephone 1100 transmits the signal for transmission obtained by the conversion processing thereof to an unshown base station via the antenna 1114.The signal for transmission (audio signal) transmitted to the base station is supplied to the cellular telephone of the other party via the public telephone network.", "Also, for example, in the voice call mode, the cellular telephone 1100 amplifies the reception signal received at the antenna 1114, at the transmission/reception circuit unit 1163, further subjects to frequency conversion processing and analog/digital conversion processing, subjects to spectrum inverse spread processing at the modulation/demodulation circuit unit 1158, and converts into an analog audio signal by the audio codec 1159.The cellular telephone 1100 outputs the converted and obtained analog audio signal thereof from the speaker 1117.Further, for example, in the event of transmitting an e-mail in the data communication mode, the cellular telephone 1100 accepts the text data of the e-mail input by the operation of the operation keys 1119 at the operation input control unit 1152.The cellular telephone 1100 processes the text data thereof at the main control unit 1150, and displays on the liquid crystal display 1118 via the LCD control unit 1155 as an image.", "Also, the cellular telephone 1100 generates e-mail data at the main control unit 1150 based on the text data accepted by the operation input control unit 1152, the user's instructions, and so forth.", "The cellular telephone 1100 subjects the e-mail data thereof to spectrum spread processing at the modulation/demodulation circuit unit 1158, and subjects to digital/analog conversion processing and frequency conversion processing at the transmission/reception circuit unit 1163.The cellular telephone 1100 transmits the signal for transmission obtained by the conversion processing thereof to an unshown base station via the antenna 1114.The signal for transmission (e-mail) transmitted to the base station is supplied to a predetermined destination via the network, mail server, and so forth.", "Also, for example, in the event of receiving an e-mail in the data communication mode, the cellular telephone 1100 receives the signal transmitted from the base station via the antenna 1114 with the transmission/reception circuit unit 1163, amplifies, and further subjects to frequency conversion processing and analog/digital conversion processing.", "The cellular telephone 1100 subjects the reception signal thereof to spectrum inverse spread processing at the modulation/demodulation circuit unit 1158 to restore the original e-mail data.", "The cellular telephone 1100 displays the restored e-mail data on the liquid crystal display 1118 via the LCD control unit 1155.Note that the cellular telephone 1100 may record (store) the received e-mail data in the storage unit 1123 via the recording/playback unit 1162.This storage unit 1123 is an optional rewritable recording medium.", "The storage unit 1123 may be semiconductor memory such as RAM, built-in flash memory, or the like, may be a hard disk, or may be a removable medium such as a magnetic disk, a magneto-optical disk, an optical disc, USB memory, a memory card, or the like.", "It goes without saying that the storage unit 1123 may be other than these.", "Further, for example, in the event of transmitting image data in the data communication mode, the cellular telephone 1100 generates image data by imaging at the CCD camera 1116.The CCD camera 1116 includes a CCD serving as an optical device such as a lens, diaphragm, and so forth, and serving as a photoelectric conversion device, which images a subject, converts the intensity of received light into an electrical signal, and generates the image data of an image of the subject.", "The CCD camera 1116 performs compression encoding of the image data at the image encoder 1153 via the camera I/F unit 1154, and converts into encoded image data.", "The cellular telephone 1100 employs the above-mentioned image encoding device 100 or image encoding device 300 as the image encoder 1153 for performing such processing.", "Accordingly, in the same way as with the image encoding device 100 or image encoding device 300, the image encoder 1053 can suppress deterioration of effects due to local control of filter processing.", "Note that, at this time simultaneously, the cellular telephone 1100 converts the audio collected at the microphone (mike) 1121, while shooting with the CCD camera 1116, from analog to digital at the audio codec 1159, and further encodes this.", "The cellular telephone 1100 multiplexes the encoded image data supplied from the image encoder 1153, and the digital audio data supplied from the audio codec 1159 at the multiplexing/separating unit 1157 using a predetermined method.", "The cellular telephone 1100 subjects the multiplexed data obtained as a result thereof to spectrum spread processing at the modulation/demodulation circuit unit 1158, and subjects to digital/analog conversion processing and frequency conversion processing at the transmission/reception circuit unit 1163.The cellular telephone 1100 transmits the signal for transmission obtained by the conversion processing thereof to an unshown base station via the antenna 1114.The signal for transmission (image data) transmitted to the base station is supplied to the other party via the network or the like.", "Note that in the event that image data is not transmitted, the cellular telephone 1100 may also display the image data generated at the CCD camera 1116 on the liquid crystal display 1118 via the LCD control unit 1155 instead of the image encoder 1153.Also, for example, in the event of receiving the data of a moving image file linked to a simple website or the like in the data communication mode, the cellular telephone 1100 receives the signal transmitted from the base station at the transmission/reception circuit unit 1163 via the antenna 1114, amplifies, and further subjects to frequency conversion processing and analog/digital conversion processing.", "The cellular telephone 1100 subjects the received signal to spectrum inverse spread processing at the modulation/demodulation circuit unit 1158 to restore the original multiplexed data.", "The cellular telephone 1100 separates the multiplexed data thereof at the multiplexing/separating unit 1157 into encoded image data and audio data.", "The cellular telephone 1100 decodes the encoded image data at the image decoder 1156 using the decoding format corresponding to a predetermined encoding format such as MPEG2, MPEG4, or the like, thereby generating playback moving image data, and displays this on the liquid crystal display 1118 via the LCD control unit 1155.Thus, moving image data included in a moving image file linked to a simple website is displayed on the liquid crystal display 1118, for example.", "The cellular telephone 1100 employs the above-mentioned image decoding device 200 or image decoding device 400 as the image decoder 1156 for performing such processing.", "Accordingly, in the same way as with the image decoding device 200 or image decoding device 400, the image decoder 1156 extracts and decodes control information supplied from the image encoding device 100 or image encoding device 300, and performs adaptive filter control processing (and filtering processing) using the control information.", "Thus, the image decoder 1156 can suppress deterioration of effects due to local control of filter processing.", "At this time, simultaneously, the cellular telephone 1100 converts the digital audio data into an analog audio signal at the audio codec 1159, and outputs this from the speaker 1117.Thus, audio data included in a moving image file linked to a simple website is played, for example.", "Note that, in the same way as with the case of e-mail, the cellular telephone 1100 may record (store) the received data linked to a simple website or the like in the storage unit 1123 via the recording/playback unit 1162.Also, the cellular telephone 1100 analyzes the imaged two-dimensional code obtained by the CCD camera 1116 at the main control unit 1150, whereby information recorded in the two-dimensional code can be obtained.", "Further, the cellular telephone 1100 can communicate with an external device at the infrared communication unit 1181 using infrared rays.", "The cellular telephone 1100 employs the image encoding device 100 or image encoding device 300 as the image encoder 1153, whereby suppression can be realized of deterioration of effects due to local control of filter processing regarding encoded data generated by encoding image data generated at the CCD camera 1116, for example.", "For example, the cellular telephone 1100 can improve the image quality of filter processing results by performing filter processing straddling slices, and can supply encoded data with higher image quality to other cellular telephones.", "Also, for example, by performing filter processing closed at the current slice, the cellular telephone 1100 can perform filter processing with low delay, and can supply encoded data to other cellular telephones with lower delay.", "Also, the cellular telephone 1100 employs the image decoding device 200 or image decoding device 400 as the image decoder 1156, whereby suppression can be realized of deterioration of effects due to local control of filter processing regarding data of a moving image file linked to at a simple website or the like, for example.", "For example, the cellular telephone 1100 can improve the image quality of filter processing results by performing filter processing straddling slices, and can realize high image quality of decoded images.", "Also, for example, by performing filter processing closed at the current slice, the cellular telephone 1100 can perform filter processing with low delay, and can decode encoded data with lower delay.", "Note that description has been made so far wherein the cellular telephone 1100 employs the CCD camera 1116, but the cellular telephone 1100 may employ an image sensor (CMOS image sensor) using CMOS (Complementary Metal Oxide Semiconductor) instead of this CCD camera 1116.In this case as well, the cellular telephone 1100 can image a subject and generate the image data of an image of the subject in the same way as with the case of employing the CCD camera 1116.Also, description has been made so far regarding the cellular telephone 1100, but the image encoding device 100 and the image decoding device 200 may be applied to any kind of device in the same way as with the case of the cellular telephone 1100 as long as it is a device having the same imaging function and communication function as those of the cellular telephone 1100, for example, such as a PDA (Personal Digital Assistants), smart phone, UMPC (Ultra Mobile Personal Computer), net book, notebook-sized personal computer, or the like.", "8.Eighth Embodiment [Hard Disk Recorder] FIG.", "26 is a block diagram illustrating a principal configuration example of a hard disk recorder which employs the image encoding device and image decoding device to which the present invention has been applied.", "A hard disk recorder (HDD recorder) 1200 shown in FIG.", "26 is a device which stores, in a built-in hard disk, audio data and video data of a broadcast program included in broadcast wave signals (television signals) received by a tuner and transmitted from a satellite or a terrestrial antenna or the like, and provides the stored data to the user at timing according to the user's instructions.", "The hard disk recorder 1200 can extract audio data and video data from broadcast wave signals, decode these as appropriate, and store in the built-in hard disk, for example.", "Also, the hard disk recorder 1200 can also obtain audio data and video data from another device via the network, decode these as appropriate, and store in the built-in hard disk, for example.", "Further, the hard disk recorder 1200 can decode audio data and video data recorded in the built-in hard disk, supply this to a monitor 1260, display an image thereof on the screen of the monitor 1260, and output audio thereof from the speaker of the monitor 1260, for example.", "Also, the hard disk recorder 1200 can decode audio data and video data extracted from broadcast signals obtained via a tuner, or audio data and video data obtained from another device via a network, supply this to the monitor 1260, display an image thereof on the screen of the monitor 1260, and output audio thereof from the speaker of the monitor 1260, for example.", "Of course, operations other than these may be performed.", "As shown in FIG.", "26, the hard disk recorder 1200 includes a reception unit 1221, a demodulation unit 1222, a demultiplexer 1223, an audio decoder 1224, a video decoder 1225, and a recorder control unit 1226.The hard disk recorder 1200 further includes EPG data memory 1227, program memory 1228, work memory 1229, a display converter 1230, an OSD (On Screen Display) control unit 1231, a display control unit 1232, a recording/playback unit 1233, a D/A converter 1234, and a communication unit 1235.Also, the display converter 1230 includes a video encoder 1241.The recording/playback unit 1233 includes an encoder 1251 and a decoder 1252.The reception unit 1221 receives the infrared signal from the remote controller (not shown), converts into an electrical signal, and outputs to the recorder control unit 1226.The recorder control unit 1226 is configured of, for example, a microprocessor and so forth, and executes various types of processing in accordance with the program stored in the program memory 1228.At this time, the recorder control unit 1226 uses the work memory 1229 according to need.", "The communication unit 1235, which is connected to the network, performs communication processing with another device via the network.", "For example, the communication unit 1235 is controlled by the recorder control unit 1226 to communicate with a tuner (not shown), and to principally output a channel selection control signal to the tuner.", "The demodulation unit 1222 demodulates the signal supplied from the tuner, and outputs to the demultiplexer 1223.The demultiplexer 1223 separates the data supplied from the demodulation unit 1222 into audio data, video data, and EPG data, and outputs to the audio decoder 1224, video decoder 1225, and recorder control unit 1226, respectively.", "The audio decoder 1224 decodes the input audio data, and outputs to the recording/playback unit 1233.The video decoder 1225 decodes the input video data, and outputs to the display converter 1230.The recorder control unit 1226 supplies the input EPG data to the EPG data memory 1227 for storing.", "The display converter 1230 encodes the video data supplied from the video decoder 1225 or recorder control unit 1226 into, for example, the video data conforming to the NTSC (National Television Standards Committee) format using the video encoder 1241, and outputs to the recording/playback unit 1233.Also, the display converter 1230 converts the size of the screen of the video data supplied from the video decoder 1225 or recorder control unit 1226 into the size corresponding to the size of the monitor 1260, converts the video data of which the screen size has been converted into the video data conforming to the NTSC format using the video encoder 1241, converts into an analog signal, and outputs to the display control unit 1232.The display control unit 1232 superimposes, under the control of the recorder control unit 1226, the OSD signal output from the OSD (On Screen Display) control unit 1231 on the video signal input from the display converter 1230, and outputs to the display of the monitor 1260 for display.", "Also, the audio data output from the audio decoder 1224 has been converted into an analog signal using the D/A converter 1234, and supplied to the monitor 1260.The monitor 1260 outputs this audio signal from a built-in speaker.", "The recording/playback unit 1233 includes a hard disk as a recording medium in which video data, audio data, and so forth are recorded.", "The recording/playback unit 1233 encodes the audio data supplied from the audio decoder 1224 by the encoder 1251.Also, the recording/playback unit 1233 encodes the video data supplied from the video encoder 1241 of the display converter 1230 by the encoder 1251.The recording/playback unit 1233 synthesizes the encoded data of the audio data thereof, and the encoded data of the video data thereof using the multiplexer.", "The recording/playback unit 1233 amplifies the synthesized data by channel coding, and writes the data thereof in the hard disk via a recording head.", "The recording/playback unit 1233 plays the data recorded in the hard disk via a playback head, amplifies, and separates into audio data and video data using the demultiplexer.", "The recording/playback unit 1233 decodes the audio data and video data by the decoder 1252 using the MPEG format.", "The recording/playback unit 1233 converts the decoded audio data from digital to analog, and outputs to the speaker of the monitor 1260.Also, the recording/playback unit 1233 converts the decoded video data from digital to analog, and outputs to the display of the monitor 1260.The recorder control unit 1226 reads out the latest EPG data from the EPG data memory 1227 based on the user's instructions indicated by the infrared signal from the remote controller which is received via the reception unit 1221, and supplies to the OSD control unit 1231.The OSD control unit 1231 generates image data corresponding to the input EPG data, and outputs to the display control unit 1232.The display control unit 1232 outputs the video data input from the OSD control unit 1231 to the display of the monitor 1260 for display.", "Thus, EPG (Electronic Program Guide) is displayed on the display of the monitor 1260.Also, the hard disk recorder 1200 can obtain various types of data such as video data, audio data, EPG data, and so forth supplied from another device via the network such as the Internet or the like.", "The communication unit 1235 is controlled by the recorder control unit 1226 to obtain encoded data such as video data, audio data, EPG data, and so forth transmitted from another device via the network, and to supply this to the recorder control unit 1226.The recorder control unit 1226 supplies the encoded data of the obtained video data and audio data to the recording/playback unit 1233, and stores in the hard disk, for example.", "At this time, the recorder control unit 1226 and recording/playback unit 1233 may perform processing such as re-encoding or the like according to need.", "Also, the recorder control unit 1226 decodes the encoded data of the obtained video data and audio data, and supplies the obtained video data to the display converter 1230.The display converter 1230 processes, in the same way as the video data supplied from the video decoder 1225, the video data supplied from the recorder control unit 1226, supplies to the monitor 1260 via the display control unit 1232 for displaying an image thereof.", "Alternatively, an arrangement may be made wherein in accordance with this image display, the recorder control unit 1226 supplies the decoded audio data to the monitor 1260 via the D/A converter 1234, and outputs audio thereof from the speaker.", "Further, the recorder control unit 1226 decodes the encoded data of the obtained EPG data, and supplies the decoded EPG data to the EPG data memory 1227.The hard disk recorder 1200 thus configured employs the image decoding device 200 or image decoding device 400 as the video decoder 1225, decoder 1252, and decoder housed in the recorder control unit 1226.Accordingly, in the same way as with the image decoding device 200 or image decoding device 400, the video decoder 1225, decoder 1252, and decoder housed in the recorder control unit 1226 extract and decode control information supplied from the image encoding device 100 or image encoding device 300, and perform adaptive filter control processing (and filter processing) using the control information.", "Accordingly, the video decoder 1225, decoder 1252, and decoder housed in the recorder control unit 1226 can suppress deterioration of effects due to local control of filter processing.", "Accordingly, the hard disk recorder 1200 can suppress deterioration of effects due to local control of filter processing regarding video data received via the tuner or communication unit 1235, and video data recorded in the hard disk of the recording/playback unit 1233, for example.", "For example, the hard disk recorder 1200 can improve the image quality of filter processing results by performing filter processing straddling slices, and can realize high image quality of decoded images.", "Also, for example, by performing filter processing closed at the current slice, the hard disk recorder 1200 can perform filter processing with low delay, and can decode encoded data with low delay.", "Also, the hard disk recorder 1200 employs the image encoding device 100 or image encoding device 300 as the encoder 1251.Accordingly, in the same way as with the case of the image encoding device 100 or image encoding device 300, the encoder 1251 can realize suppression of deterioration of effects due to local control of filter processing.", "Accordingly, the hard disk recorder 1200 can suppress deterioration of effects due to local control of filter processing regarding encoded data recorded in the hard disk, for example.", "For example, the hard disk recorder 1200 can improve the image quality of filter processing results by performing filter processing straddling slices, and can record encoded data with higher image quality in the hard disk.", "Also, for example, by performing filter processing closed at the current slice, the hard disk recorder 1200 can perform filter processing with low delay, and can generate encoded data and record in the hard disk with lower delay.", "Note that description has been made so far regarding the hard disk recorder 1200 for recording video data and audio data in the hard disk, but it goes without saying that any kind of recording medium may be employed.", "For example, even with a recorder to which a recording medium other than a hard disk, such as flash memory, optical disc, video tape, or the like, is applied, the image encoding device 100 and image decoding device 200 can be applied thereto in the same way as with the case of the above hard disk recorder 1200.9.Ninth Embodiment [Camera] FIG.", "27 is a block diagram illustrating a principal configuration example of a camera employing the image encoding device and image decoding device to which the present invention has been applied.", "A camera 1300 shown in FIG.", "27 images a subject, displays an image of the subject on an LCD 1316, and records this in a recording medium 1333 as image data.", "A lens block 1311 inputs light (i.e., picture of a subject) to a CCD/CMOS 1312.The CCD/CMOS 1312 is an image sensor employing a CCD or CMOS, which converts the intensity of received light into an electrical signal, and supplies to a camera signal processing unit 1313.The camera signal processing unit 1313 converts the electrical signal supplied from the CCD/CMOS 1312 into color difference signals of Y, Cr, and Cb, and supplies to an image signal processing unit 1314.The image signal processing unit 1314 subjects, under the control of a controller 1321, the image signal supplied from the camera signal processing unit 1313 to predetermined image processing, or encodes the image signal thereof by an encoder 1341 using the MPEG format for example.", "The image signal processing unit 1314 supplies encoded data generated by encoding an image signal, to a decoder 1315.Further, the image signal processing unit 1314 obtains data for display generated at an on-screen display (OSD) 1320, and supplies this to the decoder 1315.With the above-mentioned processing, the camera signal processing unit 1313 appropriately takes advantage of DRAM (Dynamic Random Access Memory) 1318 connected via a bus 1317 to hold image data, encoded data encoded from the image data thereof, and so forth in the DRAM 1318 thereof according to need.", "The decoder 1315 decodes the encoded data supplied from the image signal processing unit 1314, and supplies obtained image data (decoded image data) to the LCD 1316.Also, the decoder 1315 supplies the data for display supplied from the image signal processing unit 1314 to the LCD 1316.The LCD 1316 synthesizes the image of the decoded image data, and the image of the data for display, supplied from the decoder 1315 as appropriate, and displays a synthesizing image thereof.", "The on-screen display 1320 outputs, under the control of the controller 1321, data for display such as a menu screen or icon or the like made up of a symbol, characters, or a figure to the image signal processing unit 1314 via the bus 1317.Based on a signal indicating the content commanded by the user using an operating unit 1322, the controller 1321 executes various types of processing, and also controls the image signal processing unit 1314, DRAM 1318, external interface 1319, on-screen display 1320, media drive 1323, and so forth via the bus 1317.A program, data, and so forth necessary for the controller 1321 executing various types of processing are stored in FLASH ROM 1324.For example, the controller 1321 can encode image data stored in the DRAM 1318, or decode encoded data stored in the DRAM 1318 instead of the image signal processing unit 1314 and decoder 1315.At this time, the controller 1321 may perform encoding and decoding processing using the same format as the encoding and decoding format of the image signal processing unit 1314 and decoder 1315, or may perform encoding and decoding processing using a format that neither the image signal processing unit 1314 nor the decoder 1315 can handle.", "Also, for example, in the event that start of image printing has been instructed from the operating unit 1322, the controller 1321 reads out image data from the DRAM 1318, and supplies this to a printer 1334 connected to the external interface 1319 via the bus 1317 for printing.", "Further, for example, in the event that image recording has been instructed from the operating unit 1322, the controller 1321 reads out encoded data from the DRAM 1318, and supplies this to a recording medium 1333 mounted on the media drive 1323 via the bus 1317 for storing.", "The recording medium 1333 is an optional readable/writable removable medium, for example, such as a magnetic disk, a magneto-optical disk, an optical disc, semiconductor memory, or the like.", "It goes without saying that the recording medium 1333 is also optional regarding the type of a removable medium, and accordingly may be a tape device, or may be a disc, or may be a memory card.", "It goes without saying that the recoding medium 1333 may be a non-contact IC card or the like.", "Alternatively, the media drive 1323 and the recording medium 1333 may be configured so as to be integrated into a non-transportability recording medium, for example, such as a built-in hard disk drive, SSD (Solid State Drive), or the like.", "The external interface 1319 is configured of, for example, a USB input/output terminal and so forth, and is connected to the printer 1334 in the event of performing printing of an image.", "Also, a drive 1331 is connected to the external interface 1319 according to need, on which the removable medium 1332 such as a magnetic disk, optical disc, or magneto-optical disk is mounted as appropriate, and a computer program read out therefrom is installed in the FLASH ROM 1324 according to need.", "Further, the external interface 1319 includes a network interface to be connected to a predetermined network such as a LAN, the Internet, or the like.", "For example, in accordance with the instructions from the operating unit 1322, the controller 1321 can read out encoded data from the DRAM 1318, and supply this from the external interface 1319 to another device connected via the network.", "Also, the controller 1321 can obtain, via the external interface 1319, encoded data or image data supplied from another device via the network, and hold this in the DRAM 1318, or supply this to the image signal processing unit 1314.The camera 1300 thus configured employs the image decoding device 200 or image decoding device 400 as the decoder 1315.Accordingly, in the same way as with the image decoding device 200 or image decoding device 400, the decoder 1315 extracts and decodes control information supplied from the image encoding device 100 or image encoding device 300, and performs adaptive filter control processing (and filter processing) using the control information.", "Accordingly, the decoder 1315 can suppress deterioration of effects due to local control of filter processing.", "Accordingly, the camera 1300 can suppress deterioration of effects due to local control of filter processing regarding, for example, from the image data generated at the CCD/CMOS 1312, the encoded data of video data read out from the DRAM 1318 or recording medium 1333, and encoded data of video data obtained via the network.", "For example, the camera 1300 can improve the image quality of filter processing results by performing filter processing straddling slices, and can realize high image quality of decoded images.", "Also, for example, by performing filter processing closed at the current slice, the camera 1300 can perform filter processing with low delay, and can decode encoded data with low delay.", "Also, the camera 1300 employs the image encoding device 100 or image encoding device 300 as the encoder 1341.Accordingly, in the same way as with the case of the image encoding device 100 or image encoding device 300, the encoder 1341 can realize suppression of deterioration of effects due to local control of filter processing.", "Accordingly, the camera 1300 can suppress deterioration of effects due to local control of filter processing regarding the encoded data recorded in the DRAM 1318 or recording medium 1333, or encoded data to be provided to other devices, for example.", "For example, the camera 1300 can improve the image quality of filter processing results by performing filter processing straddling slices, and can record encoded data with higher image quality in the DRAM 1318 or recording medium 1333, or provide this to other devices.", "Also, for example, by performing filter processing closed at the current slice, the camera 1300 can perform filter processing with low delay, and can generate encoded data and record in the in the DRAM 1318 or recording medium 1333, or provide this to other devices, with lower delay.", "Note that the decoding method of the image decoding device 200 or image decoding device 400 may be applied to the decoding processing which the controller 1321 performs.", "In the same way, the encoding method of the image encoding device 100 or image encoding device 300 may be applied to the encoding processing which the controller 1321 performs.", "Also, the image data which the camera 1300 takes may be moving images or may be still images.", "As a matter of course, the image encoding device 100, image decoding device 200, image encoding device 300, and image decoding device 400 may be applied to devices or systems other than the above-described devices.", "Also, the size of macroblocks is not restricted to 16×16 pixels.", "Application can be made to macroblocks of various sizes, such as that of 32×32 pixels shown in FIG.", "28, for example.", "While description has been made above with flag information and the like being multiplexed (described) in the bit stream, flags and image data (or bit stream) may be transmitted (recorded), for example, besides being multiplexed.", "A form may be made where the flag and image data (or bit stream) are linked (added) as well.", "Linking (adding) indicates a state in which image data (or bit streams) and flags are mutually linked (a correlated state), and the physical positional relation is arbitrary.", "For example, the image data (or bit stream) and flags may be transmitted over separate transmission paths.", "Also, the image data (or bit stream) and flags may each be recorded in separate recording mediums (or in separate recording areas within the same recording medium).", "Note that the increments in which image data (or bit streams) and flags are linked are optional, and may be set in increments of encoding processing (one frame, multiple frames, etc.", "), for example.", "REFERENCE SIGNS LIST 100 image encoding device 112 control information generating unit 113 adaptive filter control unit 132 boundary control flag generating unit 141 system specification managing unit 142 determining unit 161 pixel to be processed 162 surrounding pixels 163 slice boundary 171 control unit 172 adaptive filter 173 selecting unit 181 buffer 182 in-slice adaptive filter 183 first adaptive filter for boundary 184 second adaptive filter for boundary 200 image decoding device 202 lossless decoding unit 207 adaptive filter processing unit 300 image encoding device 301 image encoding unit 302 input unit 303 communication unit 304 information collection unit 400 image decoding unit 401 image decoding unit 402 information providing unit 403 communication unit" ] ]
Patent_15874380
[ [ "MOTORCYCLE WITH REAR CONTROLS", "A motorcycle having rear-steering controls, including a rear handle bar for steering, for allowing a rear rider to control the motorcycle from a rearward position." ], [ "1.An at least two wheeled motorcycle comprising: a motorcycle frame; a front seat and a rear seat centrally mounted inline about said motorcycle frame; and a rear steering mechanism having a rear handlebar positioned behind said front seat, said rear steering mechanism capable of controlling a front wheel.", "2.The at least two wheeled motorcycle of claim 1 further comprising at least one rear positioned rear view mirrors disposed about said rear handlebar.", "3.The at least two wheeled motorcycle of claim 1, further comprising a front wheel coupled with a forward suspension disposed about said motorcycle frame, wherein said rear steering mechanism is hydraulically coupling said front wheel.", "4.The at least two wheeled motorcycle of claim 1, further comprising a front handle bar capable of controlling a front wheel controllable independent of said rear handlebar.", "5.The at least two wheeled motorcycle of claim 3 further comprising at least one hydraulic cable interposed between said forward suspension and said rear handlebar.", "6.The at least two wheeled motorcycle of claim 4 further comprising an adjustable control for switching control of steering between a front handle bar disposed about said motorcycle frame and said rear handlebar.", "7.The at least two wheeled motorcycle of claim 1 wherein said at least two wheeled motorcycle is a trike having a centrally mounted front wheel and two laterally displaced rear wheels.", "8.The at least two wheeled motorcycle of claim 7 further comprising a left and right platform on a left and right side of said motorcycle frame.", "9.An at least two wheeled motorcycle comprising: a motorcycle frame; a front steering column with a front wheel and a front handle bar for steering, said front steering column rotatably secured about said frame; a front seat and a rear seat centrally mounted inline about said motorcycle frame, said rear seat including a back rest; and a rear steering mechanism having a rear handlebar positioned behind said front seat, said rear steering mechanism capable of controlling a front wheel independent of said front handle bar.", "10.The at least two wheeled motorcycle of claim 9 further comprising at least one rear brake lever, said at least one rear brake lever capable of applying brakes to at least one of said front wheel and a back wheel.", "11.The at least two wheeled motorcycle of claim 9 further comprising at least one rear clutch member capable of disengaging a clutch of the at least two wheeled motorcycle.", "12.The at least two wheeled motorcycle of claim 9 further comprising at least one rear brake lever, said at least one rear hand brake lever capable of applying brakes to at least one of said front wheel and a back wheel.", "13.The at least two wheeled motorcycle of claim 9 further comprising at least one rear foot brake lever, said at least one rear foot brake lever capable of applying brakes to at least one of said front wheel and a back wheel." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Motorcycles have been used for a long period of time.", "Due to the fact that the steering is configured for the front most driver, it was not previously possible to integrate other activities with the motorcycle.", "Typically, such motorcycles are built as a two wheeled motorcycle or three wheeled motorcycle tricycle.", "While a select few innovations for a motorcycle with a drum set generally exists, those prior art innovations differ from the present invention.", "For example, prior art motorcycles appear to integrate a drum set as a side car.", "Thus, no known prior art includes a two wheeled motorcycle and/or a three wheeled motorcycle tricycle with a centrally integrated drum set.", "The uncovered prior art is side heavy due to the placement of the drum set as a sidecar, which reduces the drivability of the existing motorcycles and prevents consistent turning.", "There is a need in the art for a motorcycle tricycle that includes an integrated drum set and allows for the drummer to be positioned central about the motorcycle tricycle." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention advantageously provides a motorcycle with integrated rear controls.", "According to an embodiment of the present invention, a principal object is to provide two or three wheeled motorcycle (“motorcycle”) with an rear controls.", "According to an embodiment of the present invention, another object is to provide a drum set that is mirrored on both sides of the motorcycle.", "According to an embodiment of the present invention, another object is to provide a motorcycle with a rear steering mechanism.", "Also, the rear steering allows for a person to play the drum set during operation of the motorcycle.", "Other objects will become evident as the present invention is described in detail below." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation of and claims benefit to U.S. application Ser.", "No.", "15/238,418, filed Aug. 16, 2016, which claims the benefit to U.S.", "Provisional Patent Application Ser.", "No.", "62/205,850, filed Aug. 17, 2015, entitled “TRIKE WITH DRUM SET,” both of which are hereby incorporated herein by reference in their entirety for all purposes.", "FIELD OF THE INVENTION The present invention relates to motorcycle, and more particularly to a motorcycle with rear motorcycle controls.", "BACKGROUND OF THE INVENTION Motorcycles have been used for a long period of time.", "Due to the fact that the steering is configured for the front most driver, it was not previously possible to integrate other activities with the motorcycle.", "Typically, such motorcycles are built as a two wheeled motorcycle or three wheeled motorcycle tricycle.", "While a select few innovations for a motorcycle with a drum set generally exists, those prior art innovations differ from the present invention.", "For example, prior art motorcycles appear to integrate a drum set as a side car.", "Thus, no known prior art includes a two wheeled motorcycle and/or a three wheeled motorcycle tricycle with a centrally integrated drum set.", "The uncovered prior art is side heavy due to the placement of the drum set as a sidecar, which reduces the drivability of the existing motorcycles and prevents consistent turning.", "There is a need in the art for a motorcycle tricycle that includes an integrated drum set and allows for the drummer to be positioned central about the motorcycle tricycle.", "SUMMARY OF THE INVENTION The present invention advantageously provides a motorcycle with integrated rear controls.", "According to an embodiment of the present invention, a principal object is to provide two or three wheeled motorcycle (“motorcycle”) with an rear controls.", "According to an embodiment of the present invention, another object is to provide a drum set that is mirrored on both sides of the motorcycle.", "According to an embodiment of the present invention, another object is to provide a motorcycle with a rear steering mechanism.", "Also, the rear steering allows for a person to play the drum set during operation of the motorcycle.", "Other objects will become evident as the present invention is described in detail below.", "BRIEF DESCRIPTION OF THE DRAWINGS Embodiments of the present application are described herein in which similar elements are given similar reference characters, and a more complete understanding of the present invention, and the attendant advantages and features thereof, will be more readily understood by reference to the following detailed description when considered in conjunction with the accompanying drawings wherein: FIG.", "1 is a right side perspective view of one embodiment of the motorcycle tricycle with an integrated drum set in accordance with the principles of the present invention; FIG.", "2 is a left side perspective view of the motorcycle tricycle with an integrated drum set in accordance with the principles of the present embodiment; FIG.", "3 is a right side perspective view of the motorcycle tricycle with a view through one floor tom in accordance with the principles of the present embodiment; FIG.", "4 is a front perspective view of the motorcycle tricycle with an integrated drum set in accordance with the principles of the present embodiment; FIG.", "5 is a rear perspective view of the motorcycle tricycle with an integrated drum set in accordance with the principles of the present embodiment; and FIG.", "6 is a partial perspective view of a front seat of the motorcycle tricycle with a partial view of the integrated drum set in accordance with the principles of the present embodiment.", "DETAILED DESCRIPTION OF THE INVENTION The present invention advantageously provides a motorcycle having at least two wheels with integrated rear motorcycle controls.", "The present invention contemplates various types of motorcycles with at least two centrally mounted seats with rear motorcycle controls.", "Accordingly, the present invention components have been represented where appropriate by conventional symbols in the drawings, showing only those specific details that are pertinent to understanding the embodiments of the present invention so as not to obscure the disclosure with details that will be readily apparent to those of ordinary skill in the art having the benefit of the description herein.", "Referring now to the drawings figures in which like reference designators refer to like elements.", "FIG.", "1 shows an exemplary motorcycle tricycle (hereafter “trike”) with an integrated drum set constructed in accordance with the principles of the present invention and designated generally as trike “10.” In particular, trike 10 includes a three wheel trike frame body 12.The body 12 includes a front trike suspension 14 and a rear trike suspension 36.The front trike suspension 14 carries a steerable front wheel 16.Other various conventional motorcycle components are included; for example, a front steering mechanism 18, mirrors 20, fuel tank 22; brakes 24; exhaust 38; brake lights 39.The front steering mechanism 18 includes without limitation handle bars, throttle control, and brake levers for initiating tire braking.", "The instant invention further includes a conventional engine 26 for propelling the trike 10 forward.", "A front seat 28 and a rear seat 30 are provided centrally mounted in an inline configuration.", "The rear seat 30 includes a back rest 32.The back rest 32 is supported via a back rest support member 34.A rear steering mechanism 40 is provided that controls the position of the steerable front wheel 16.The nonconventional rear steering mechanism 40 includes rear handlebar 42 having dual handgrips 44, 46 for gripping.", "The handgrips 44, 46 includes padding 51 disposed over at least a portion of the handgrips 44, 46 for the comfort of the rider.", "One or more rear positioned rear view mirrors 48 coupled with the rear handlebar 42.One or more brake levers 50 are coupled with the handlebar 42 for engaging one or more front brakes 24 and/or rear brakes (not shown) when pressure is applied by the rider to the brake levers 50.In one embodiment, the rear steering mechanism 40 is hydraulically driven and/or otherwise coupled to the front trike suspension 14 for controlling the front wheel 16.One or more hydraulic cables 140 secured between the rear steering mechanism 40 and the front trike suspension 14 for turning the front wheel 16.In yet another embodiment, the rear steering mechanism 40 can be used independently of the conventional front handle bars.", "In one non-limiting embodiment, a switch (not shown) can be adjusted to switch the control of the front wheel 16 between the front steering mechanism 18 and the rear steering mechanism 40.A right side platform 52 (see FIG.", "1) and a left side platform 54 (see FIG.", "2) are mounted to the frame body 12.The right and left side platforms 52, 54 should be mounted at a height above the ground to provide the necessary clearance to safely ride the trike on roadways.", "As illustrated in FIG.", "4, a drum rack assembly 56 is mounted on the right and left side platforms 52, 54.The drum rack assembly includes a right t-leg assembly 58 that is mounted with the right side platform 52 and a left t-leg assembly 60 that is mounted with the left side platform 54.Each of the right and left t-leg assemblies 58, 60 include a t-leg clamp 62, 64.The t-leg assemblies 58, 60 each include horizontal leg sections 66 and a plurality of feet 68 for stabilization.", "A right leg 70 and a left leg 72, each having a first and second end, engage the t-leg assemblies 58, 60 respectively at one end thereof, as illustrated in FIG.", "3.The right and left legs each engage horizontal clamp assemblies 74, 76 on their opposite ends.", "A horizontal upper bar 78 is configured to maintain a number of boom arms or other members thereof.", "The horizontal upper bar 78 is provided as a straight bar, however, a curved bar may be implemented without departing from the spirit and scope of the instant invention.", "The horizontal upper bar 78 is positioned forward from the handlebars to prevent interference during turning, as illustrated in FIG.", "1.A right cymbal boom assembly 80 and a left cymbal boom assembly 82 is coupled on their first end to the horizontal upper bar 78 via a cymbal boom clamp assembly 84, 86.The cymbal boom clamp assemblies 84, 86 prevent the cymbal boom assemblies 80, 82 from sliding about the horizontal upper bar 78 when clampedly engaged.", "The right and left cymbal boom assemblies 80, 82 are coupled with a cymbal on their opposite ends, 92, 94.While the instant invention shows only one cymbal 92, 94 coupled with the right and left cymbal boom assemblies, additional crash cymbals, or other types of cymbals, may be coupled with the cymbal boom assemblies 80, 82 such that two or more cymbals are secured to each cymbal boom assembly 80, 82.A drum boom 88 is coupled to the horizontal upper bar 78 via a drum boom clamp assembly 90 on a first portion 91 and coupled to a drum 144 on a second portion 93.Other arms and booms may be secured to the drum rack assembly 56 as desired or required.", "The horizontal upper bar 78 is fluted, dovetailed or otherwise constructed to prevent the boom assemblies 84, 86, 90 from spinning but still allow the boom assemblies 84, 86, 90 to slide freely when any of the clamp assemblies 84, 86, 90 are in an unlocked position thereof.", "Referring now to FIG.", "2, a detailed left side view of the trike 10 is shown.", "A base drum 96 with an accompanying foot pedal 98 (see FIG.", "3 for a same or similar foot pedal 107) is mounted to the left side platform 54.The base drum 96 coupled with a bass drum pedal 98 as would be conventionally understood and operated (See FIG.", "6).", "A floor tom 100 is mounted to the left side platform 54.A floor cymbal 102 is mounted to the left side platform 54 via a floor mount 104.Referring again to FIG.", "1, a base drum 106 is mounted to the right side platform 52.The base drum 106 coupled with a bass drum pedal 108 as would be conventionally understood and operated (see FIG.", "6).", "A floor tom 110 is mounted to the right side platform 52.A floor cymbal 112 is mounted to the right side platform 52 via a floor mount 114.A hi-hat cymbal assembly 116 is coupled with the horizontal upper bar 78.The hi-hat cymbal assembly 116 includes hi-hat cymbals 118 and a hi-hat arm 120.In one embodiment, the hi-hat arm 120 is coupled via a clamp assembly 122 on an end 124 to the horizontal upper bar 78.The hi-hat assembly 116 includes a portion 126 that connects with a hi-hat foot pedal assembly 128 for controlling the distance between the hi-hat cymbals 118.Referring again to FIG.", "2, a hi-hat cymbal assembly 130 is coupled with the horizontal upper bar 78.The hi-hat cymbal assembly 130 includes hi-hat cymbals 132 and a hi-hat arm 134.In one embodiment, the hi-hat arm 134 is coupled via a clamp assembly 136 on an end 124 to the horizontal upper bar 78.The hi-hat assembly 130 includes a portion 138 that connects with a hi-hat foot pedal assembly (not shown but the same or similar to the foot pedal assembly 128 shown in FIG.", "3) for controlling the distance between the hi-hat cymbals 132.Referring now to FIG.", "6, a partial perspective view of the front seat of the motorcycle tricycle is shown.", "A snare drum or other drum 142 is mounted centrally about the trike 10 on or above the gas tank.", "In one embodiment, the drums installed on the motorcycle are mirrored in all aspects, including size and shape, between the right and left sides of the motorcycle tricycle.", "In one nonlimiting embodiment, the motorcycle includes rear motorcycle controls in conjunction with the rear handle bar 42, the rear motorcycle controls include without limitation a throttle, front brake controls, rear brake controls, clutch, and gear shifter.", "These rear motorcycle controls are controllable by an operator sitting in the rear seat of the motorcycle.", "Optionally, the motorcycle includes one or more control mechanism members for allowing simultaneous control of the throttle, front brake controls, rear brake controls, clutch, and gear shifter(s) from two separator motorcycle riders/operators.", "As used herein, when the term “and/or” is used, it shall include all combinations of one or more of the associated described items.", "It will be appreciated by persons skilled in the art that the present invention is not limited to what has been particularly shown and described herein above.", "In addition, unless mention was made above to the contrary, it should be noted that all of the accompanying drawings are not to scale.", "A variety of modifications and variations are contemplated in light of the above teachings without departing from the scope and spirit of the invention.", "It will be readily apparent that various changes may be made thereto without departing from the spirit and scope of the disclosure or sacrificing all of its material advantages.", "The examples and embodiments described herein are merely exemplary of the instant disclosure." ] ]
Patent_15874382
[ [ "RESONATION DEVICE, OSCILLATOR, ELECTRONIC APPARATUS, AND MOVING OBJECT", "In a crystal resonator, a resonator element is installed in a package via a first bonding member and a second bonding member, and when viewed from above, a distance between a first bonding center and a second bonding center is set to be L1, and a length of a perpendicular line drawn to a virtual line which connects the first bonding center and the second bonding center from the resonation area center is set to be L2, a relationship expressed by 0<L1/L2≤0.97 is satisfied." ], [ "1.A resonation device comprising: a substrate; a resonator element that is provided above that substrate and that is configure to resonate, the resonator element including: a resonation area having first and second surfaces opposite to each other, the resonation area having a resonation center in a plan view; and first and second excitation electrodes that are provided on the first and second surfaces of the resonation area, respectively; and a first bonding member and a second bonding member that connect the resonator element to the substrate, a first bonding center of the first bonding member in the plan view and a second bonding center of the second bonding member in the plan view being disposed along a first direction, wherein when a bonding center length between the first and second bonding centers is L1 and a perpendicular length of a perpendicular line drawn to a first virtual line which connects the first and second bonding centers from the resonation center of the resonation area is L2, 0<L1/L2≤0.97 is satisfied, wherein a second virtual line passes through the resonation center and is parallel to the first direction, a distance between the first bonding center and the perpendicular line is La, a distance between the second bonding center and the perpendicular line is Lb, a distance between the resonation center and a first end of the resonation area, which is positioned on a side of the first bonding member with respect to the perpendicular line and intersects with the second virtual line, is Wa, and a distance between the resonation center and a second end of the resonation area, which is positioned on a side of the second bonding member with respect to the perpendicular line and intersects with the second virtual line, is Wb, and wherein in case of La/Wa>Lb/Wb, a relationship of 0<La/Wa≤0.89 is satisfied, and in case of La/Wa<Lb/Wb, a relationship of 0<Lb/Wb≤0.89 is satisfied.", "2.The resonation device according to claim 1, wherein each of the first and second excitation electrodes is configured with a base layer and an upper layer stacked to each other, the base layer is provided closer to the resonator element than the upper layer, and the base layer includes at least one of nickel and tungsten, and the upper layer includes at least one of gold, platinum, silver, aluminum, and copper.", "3.The resonation device according to claim 1, wherein the resonator element includes: a first area that has a first thickness and that is provided in a vicinity of the resonation center of the resonation area; and a second area that has a second thickness and that is located directly adjacent to the first area, the second thickness is smaller than the first thickness, the resonation center of the resonation area is overlapped with the first area in the plan view, and the first bonding center of the first bonding member and the second bonding center of the second bonding member are overlapped with the second area in the plan view.", "4.The resonation device according to claim 2, wherein the resonator element includes: a first area that has a first thickness and that is provided in a vicinity of the resonation center of the resonation area; and a second area that has a second thickness and that is located directly adjacent to the first area, the second thickness is smaller than the first thickness, the resonation center of the resonation area is overlapped with the first area in the plan view, and the first bonding center of the first bonding member and the second bonding center of the second bonding member are overlapped with the second area in the plan view.", "5.The resonation device according to claim 1, wherein 0<L1/L2≤0.85 is satisfied.", "6.The resonation device according to claim 1, wherein in case of La/Wa>Lb/Wb, a relationship of 0<La/Wa≤0.77 is satisfied, and in case of La/Wa<Lb/Wb, a relationship of 0<Lb/Wb≤0.77 is satisfied.", "7.The resonation device according to claim 1, wherein the resonator element has a thin area, the thin area has a thickness smaller than another area of the resonator element, and the thin area is located between the first virtual line and one of the first and second excitation electrodes in the plan view.", "8.The resonation device according to claim 1, wherein the resonator element has a through hole, and the through hole is located between the first virtual line and one of the first and second excitation electrodes in the plan view.", "9.The resonation device according to claim 1, wherein the first bonding member and the second bonding member have conductivity.", "10.The resonation device according to claim 1, wherein at least one of the first bonding member and the second bonding member is a metallic bump.", "11.An oscillator comprising: the resonation device according to claim 1, the resonation device having a lid, the lid being fixed to the substrate so as to create an inner space in which the resonator element is enclosed; an oscillation circuit that is connected to the resonation device via a first conductor; and a container that accommodates the resonation device and the oscillation circuit.", "12.An oscillator comprising: the resonation device according to claim 2, the resonation device having a lid, the lid being fixed to the substrate so as to create an inner space in which the resonator element is enclosed; an oscillation circuit that is connected to the resonation device via a first conductor; and a container that accommodates the resonation device and the oscillation circuit.", "13.An oscillator comprising: the resonation device according to claim 3, the resonation device having a lid, the lid being fixed to the substrate so as to create an inner space in which the resonator element is enclosed; an oscillation circuit that is connected to the resonation device via a first conductor; and a container that accommodates the resonation device and the oscillation circuit.", "14.An oscillator comprising: the resonation device according to claim 4, the resonation device having a lid, the lid being fixed to the substrate so as to create an inner space in which the resonator element is enclosed; an oscillation circuit that is connected to the resonation device via a first conductor; and a container that accommodates the resonation device and the oscillation circuit.", "15.The oscillator according to claim 11, wherein the lid and the oscillation circuit are connected to each other via a second conductor.", "16.The oscillator according to claim 12, wherein the lid and the oscillation circuit are connected to each other via a second conductor.", "17.The oscillator according to claim 13, wherein the lid and the oscillation circuit are connected to each other via a second conductor.", "18.The oscillator according to claim 14, wherein the lid and the oscillation circuit are connected to each other via a second conductor.", "19.An electronic apparatus comprising: the resonation device according to claim 1; a display; and a housing that accommodates the resonation device and the display.", "20.A moving object comprising: the resonation device according to claim 1; and a movable body that accommodates the resonation device." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>An advantage of some aspects of the invention is to solve at least a part of the problems described above, and the invention can be implemented as the following forms or application examples." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/618,592, filed Jun.", "9, 2017, which is a continuation of U.S. patent application Ser.", "No.", "14/988,158, filed Jan. 5, 2016, now U.S. Pat.", "No.", "9,712,109 issued Jul.", "18, 2017, which claims priority to Japanese Patent Application Nos.", "2015-000676, filed Jan. 6, 2015, and 2015-000680, filed Jan. 6, 2015, all of which are expressly incorporated by reference herein in their entireties.", "BACKGROUND 1.Technical Field The present invention relates to a resonation device, an oscillator, an electronic apparatus, and a moving object.", "2.Related Art In a communication equipment industry, in order to obtain a stable frequency signal, a resonation device such as a crystal resonator and a crystal oscillator which output a desired frequency signal by using a resonator element which is formed of a piezoelectric substance such as a crystal has been used for a long time.", "For example, as disclosed in JP-A-2014-86842, the resonation device, which cantilever-supports the resonator element on a connection pad in a container by using an electroconductive adhesive, is configured to stably secure a thickness of the electroconductive adhesive by providing a bank portion on an electrode pad in the container.", "In such a configuration, the resonation device reduces a temperature gradient in the resonator element by reducing heat from being transferred to the resonator element from the outside of the container via an electroconductive adhesive so as to reduce the variation in frequency characteristics of the resonation device, for example, reproducibility of a frequency change with respect to a temperature change, that is, a hysteresis.", "However, in the resonation device disclosed in JP-A-2014-86842, the hysteresis which is the variation in frequency characteristics of the resonation device is also changed due to a stress which is caused by an ambient temperature change of the resonation device and is applied to the resonator element, other than the heat transferred from the outside of the container.", "The stress which is caused by the ambient temperature change of the resonation device and is applied to the resonator element greatly affects a positional relationship between a distance between connection members which connect the resonator element and the container and an excitation electrode of the resonator element.", "For this reason, it is likely that the variation in characteristics of the resonation device, for example, the hysteresis is increased by when only securing the stable thickness of the electroconductive adhesive which connects the container and the resonator element as the resonation device disclosed in JP-A-2014-86842.SUMMARY An advantage of some aspects of the invention is to solve at least a part of the problems described above, and the invention can be implemented as the following forms or application examples.", "Application Example 1 A resonation device according to this application example includes a substrate; a resonator element which includes a resonation area interposed between a pair of excitation electrodes which are disposed on a front surface and a rear surface; and a first bonding member and a second bonding member which bond the resonator element and the substrate, and are disposed side by side in a first direction along the first side of the resonator element, in which the excitation electrode includes a base layer including at least one type of metal of nickel and tungsten on the front and rear surface, and an upper layer including at least one type of metal among gold, platinum, silver, aluminum, and copper on the base layer, the center of a resonator element-side surface of the first bonding member is set to be a first bonding center, the center of a resonator element-side surface of the second bonding member is set to be a second bonding center, and a center which is viewed from one side of the pair of excitation electrodes in the resonation area is set to be a resonation area center, and when a distance between the first bonding center and the second bonding center is set to be L1, and a length of a perpendicular line drawn to a virtual line which connects the first bonding center and the second bonding center from the resonation area center is set to be L2, a relationship expressed by 0<L1/L2≤0.97 is satisfied.", "According to this application example, in a case where the stress is generated due to a difference between an elongation amount or a shrinkage amount of the resonator element and an elongation amount or a shrinkage amount of the substrate, in accordance with the change of the ambient temperature of the resonation device, it is possible to reduce the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate, so as not to be transferred to the resonation area of the resonator element by satisfying a relationship expressed by 0<L1/L2≤0.97.The characteristics of the resonator element, for example, an output frequency, a frequency-temperature characteristic, and an equivalent series resistance are greatly varied depending on a state of the resonation area, and thus when the stress transferred to the resonation area is reduced, and thus it is possible to reduce the variation in characteristics of the resonation device, for example, the variation in the frequency-temperature characteristic or the hysteresis.", "Application Example 2 In the resonation device according to the application example, it is preferable that a relationship expressed by 0<L1/L2≤0.85 is satisfied.", "According to this application example, for example, in a case where the stress is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate, in accordance with the change of the ambient temperature of the resonation device, it is possible to further reduce the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate, so as not to be transferred to the resonation area of the resonator element by satisfying a relationship expressed by 0<L1/L2≤0.85.Accordingly, when the stress transferred to the resonation area of the resonator element is reduced, it is possible to further reduce the variation in characteristics of the resonation device, for example, the hysteresis compared with Application Example 1.Application Example 3 In the resonation device according to the application example, it is preferable that when a virtual line which passes through the resonation area center and is parallel to the first direction is set to be a third virtual line, a distance between the first bonding center and the perpendicular line is set to be La, a distance between the second bonding center and the perpendicular line is set to be Lb, a distance between the resonation area center and an end portion of the resonation area, which is positioned on the first bonding member side with respect to the perpendicular line and intersects with the third virtual line, is set to be Wa, and a distance between the resonation area center and an end portion of the resonation area, which is positioned on the second bonding member side with respect to the perpendicular line and intersects with the third virtual line, is set to be Wb, in case of La/Wa>Lb/Wb, relationship expressed by 0<La/Wa≤0.89 is satisfied, and in case of La/Wa<Lb/Wb, relationship expressed by 0<Lb/Wb≤0.89 is satisfied.", "According to this application example, in a case where the stress is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate, in accordance with the change of the ambient temperature of the resonation device, it is possible to reduce the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate, so as not to be transferred to the resonation area of the resonator element by respectively satisfying the relationships expressed by 0<La/Wa≤0.89 and 0<Lb/Wb≤0.89 in the cases of La/Wa>Lb/Wb and La/Wa<Lb/Wb.", "The characteristics of the resonator element, for example, the output frequency, the frequency-temperature characteristic, and the equivalent series resistance are greatly varied depending on the state of the resonation area, and thus when the stress transferred to the resonation area is reduced, and thus it is possible to reduce the variation in characteristics of the resonation device, for example, the variation in the frequency-temperature characteristic or the hysteresis.", "Application Example 4 In the resonation device according to the application example, it is preferable that in case of La/Wa>Lb/Wb, relationship expressed by 0<La/Wa≤0.77 is satisfied, and in case of La/Wa<Lb/Wb, relationship expressed by 0<Lb/Wb≤0.77 is satisfied.", "According to this application example, for example, in a case where the stress is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate, in accordance with the change of the ambient temperature of the resonation device, it is possible to further reduce the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate, so as not to be transferred to the resonation area of the resonator element by respectively satisfying the relationships expressed by 0<L1/W1≤0.77 and 0<L2/W2≤0.77 in the cases of L1/W1>L2/W2 and L1/W1<L2/W2.Accordingly, when the stress transferred to the resonation area of the resonator element is further reduced, it is possible to reduce the variation in characteristics of the resonation device, for example, the hysteresis by 28% or more than that in Application Example 3.Application Example 5 In the resonation device according to the application example, it is preferable that in a planar view, the resonator element includes a hollow between the virtual line which connects the first bonding center and the second bonding center, and the excitation electrode in a direction in which at least one surface of the front surface and the rear surface faces the other surface.", "According to this application example, the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate in accordance with the change of the ambient temperature of the resonation device, is also transferred to the resonation area via a hollow, and a length of a portion in which the hollow is formed is shorter than that of a portion in which the hollow is not formed in the direction intersecting with the front surface and the rear surface, that is, the portion in which the hollow is formed is thin, and thus is easily distorted.", "Accordingly, the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate in accordance with the change of the ambient temperature of the resonation device, is absorbed because the portion in which the hollow is formed is much more distorted than the portion in which the hollow is not formed, and thus when the stress transferred to the resonation area of the resonator element is reduced, it is possible to further reduce the variation in characteristics of the resonation device, for example, the variation in the frequency-temperature characteristic, or the hysteresis.", "Application Example 6 In the resonation device according to the application example, it is preferable that the hollow is a hole which penetrates from one surface of the front surface and the rear surface to the other surface.", "According to this application example, the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate in accordance with the change of the ambient temperature of the resonation device, is transferred to the resonation area via an area in which the hole is not opened and an area adjacent to an area in which the hole is opened of the resonator element, and the area adjacent to the area in which the hole is opened of the resonator element is more easily distorted than the area which is not adjacent to the area in which the hole is opened, that is, the area in which the hole is not opened.", "Accordingly, the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate in accordance with the change of the ambient temperature of the resonation device, is absorbed because the area adjacent to the area in which the hole is opened of the resonator element is much more distorted than the area in which the hole is not opened, and thus when the stress transferred to the resonation area of the resonator element is reduced, it is possible to further reduce the variation in characteristics of the resonation device, for example, the variation in the frequency-temperature characteristic, or the hysteresis.", "Application Example 7 In the resonation device according to the application example, it is preferable that the resonator element includes a first area having a first thickness and a second area having a thickness which is smaller than the first thickness in the direction which intersects with the front surface and the rear surface, in which the resonation area center overlaps the first area in a planar view, and the first bonding center and the second bonding center overlaps the second area in planar view.", "According to this application example, the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate in accordance with the change of the ambient temperature of the resonation device, is transferred to the resonation area via second area, and the second area is thinner than the first area and thus is more easily distorted.", "Accordingly, the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element and the elongation amount or the shrinkage amount of the substrate in accordance with the change of the ambient temperature of the resonation device, is absorbed because the second area is much more distorted than the first area, and thus when the stress transferred to the resonation area of the resonator element is further reduced, it is possible to further reduce the variation in characteristics of the resonation device, for example, the variation in the frequency-temperature characteristic, or the hysteresis.", "Application Example 8 In the resonation device according to the application example, it is preferable that the first bonding member and the second bonding member have conductivity.", "According to this application example, the first bonding member and the second bonding member have the conductivity, and thus a mechanical bonding and an electrical bonding can be concurrently performed between the resonator element and the substrate.", "Accordingly, it is possible to reduce the number of members used for the resonation device compared with a case where the mechanical bonding and the electrical bonding which are performed between the resonator element and the substrate by using different members, and thus it is possible to efficiently manufacture the resonation device in which the variation in the frequency-temperature characteristic, the hysteresis, or the like is reduced.", "Application Example 9 In the resonation device according to the application example, it is preferable that at least one of the first bonding member and the second bonding member is formed of a metallic bump.", "According to this application example, at least one of the first bonding member and the second bonding member is formed of the metallic bump, for example, metal which is formed through a plating method and a bonding method.", "The metallic bump has less gas emission from the inside of the metallic bump due to the heat and the time elapse compared with a resin member such as an adhesive.", "Accordingly, it is possible to reduce the variation in characteristics of the resonation device, for example, the variation in the frequency-temperature characteristic or the hysteresis, and to reduce the variation of the characteristics of the resonation device, for example, the output frequency, the frequency-temperature characteristic, and the equivalent series resistance due to the heat and the time elapse of the resonation device.", "Application Example 10, Application Example 11, Application Example 12, and Application Example 13 An oscillator according to each of these application examples includes the resonation device according to any one of the above-described application examples, which is bonded to the substrate and has a lid which forms an inner space for accommodating the resonator element; an oscillation circuit which is connected to one surface of the resonation device via a bonding member; and a container which accommodates the resonation device and the oscillation circuit.", "According to these application examples, it is possible to realize the oscillator having high reliability in which the variation in characteristics is reduced, for example, the variation in the frequency-temperature characteristic or the hysteresis is reduced by using the resonation device which reduces the variation in characteristics by reducing the stress which is generated due to a difference between an elongation amount or a shrinkage amount of the resonator element and an elongation amount or a shrinkage amount of the substrate in accordance with the change of the ambient temperature of the resonation device, so as not to be transferred to the resonator element.", "Application Example 14, Application Example 15, Application Example 16, and Application Example 17 In the oscillator according to the application examples, the lid and the oscillation circuit may be connected to each other via bonding member in the oscillator according to any one of the above-described application examples.", "According to these application examples, it is possible to realize the oscillator having high reliability in which the variation in characteristics, for example, the variation in the frequency-temperature characteristic or the hysteresis is reduced by using the resonation device which reduces the variation in characteristics by reducing the stress which is generated due to a difference between an elongation amount or a shrinkage amount of the resonator element and an elongation amount or a shrinkage amount of the substrate in accordance with the change of the ambient temperature of the resonation device, so as not to be transferred to the resonator element.", "Application Example 18 An electronic apparatus according to this application example includes the resonation device according to any one of the above-described application examples.", "According to this application example, it is possible to realize the electronic apparatus having high reliability in which the variation in characteristics, for example, the variation in the frequency-temperature characteristic or the hysteresis is reduced by using the resonation device which reduces the variation in characteristics by reducing the stress which is generated due to a difference between an elongation amount or a shrinkage amount of the resonator element and an elongation amount or a shrinkage amount of the substrate in accordance with the change of the ambient temperature of the resonation device, so as not to be transferred to the resonator element.", "Application Example 19 A moving object according to this application example includes the resonation device according to any one of the above-described application examples.", "According to this application example, it is possible to realize the moving object having high reliability in which the variation in characteristics, for example, the variation in the frequency-temperature characteristic or the hysteresis is reduced by using the resonation device which reduces the variation in characteristics by reducing the stress which is generated due to a difference between an elongation amount or a shrinkage amount of the resonator element and an elongation amount or a shrinkage amount of the substrate in accordance with the change of the ambient temperature of the resonation device, so as not to be transferred to the resonator element.", "BRIEF DESCRIPTION OF THE DRAWINGS The invention will be described with reference to the accompanying drawings, wherein like numbers reference like elements.", "FIGS.", "1A and 1B are schematic configuration diagrams of a crystal resonator 100 as a resonation device according to a first embodiment, and FIG.", "1A is a plan view and FIG.", "1B is a sectional view taken along line A-A of FIG.", "1A.", "FIGS.", "2A and 2B are diagrams illustrating deflection of the resonator element according to the first embodiment, and FIG.", "2A is a sectional view taken along a first virtual line when a relationship expressed by L1=W1 is satisfied in FIG.", "1A, and FIG.", "2B is a sectional view taken along the first virtual line when a relationship expressed by L1=W2 is satisfied in FIG.", "1A.", "FIGS.", "3A and 3B are diagrams illustrating a stress applied to the resonator element according to the first embodiment, and FIG.", "3A is a sectional view taken along a second virtual line in FIG.", "1A, and FIG.", "3B is a schematic view of a stress distribution when relationships expressed by L1=W1 and L1=W2 are satisfied.", "FIG.", "4 is a diagram illustrating a relationship between L1/L2 and a hysteresis of a frequency-temperature characteristic of the crystal resonator.", "FIGS.", "5A and 5B are schematic configuration diagrams of a crystal resonator 200 as a resonation device according to a second embodiment, and FIG.", "5A is a plan view and FIG.", "5B is a sectional view taken along line B-B of FIG.", "5A.", "FIGS.", "6A and 6B are schematic configuration diagrams of a crystal resonator 300 as a resonation device according to a third embodiment, and FIG.", "6A is a plan view and FIG.", "6B is a sectional view taken along line C-C of FIG.", "6A.", "FIGS.", "7A and 7C are schematic configuration diagrams of a crystal resonator 400 as a resonation device according to a fourth embodiment, and FIG.", "7A is a plan view, FIG.", "7B is a sectional view taken along line D-D of FIG.", "7A, and FIG.", "7C is a sectional view of a part of an excitation electrode portion.", "FIGS.", "8A and 8E are schematic configuration diagrams illustrating Modification Example of the resonator element of the crystal resonator 400 as the resonation device according to the fourth embodiment, and FIG.", "8A is a plan view of the resonator element 410 which is an example of Modification Example, FIG.", "8B is a sectional view taken along line E-E in FIG.", "8A, FIG.", "8C is a plan view of the resonator element 510 which is another example of Modification Example, FIG.", "8D is a sectional view taken along line F-F in FIG.", "8C, and FIG.", "8E is a partially enlarged sectional view of an excitation electrode portion in FIG.", "8D.", "FIGS.", "9A and 9B are schematic configuration diagrams of a crystal resonator 500 as a resonation device according to a fifth embodiment, and FIG.", "9A is a plan view and FIG.", "9B is a sectional view taken along line G-G of FIG.", "9A.", "FIGS.", "10A and 10B are schematic configuration diagrams of a crystal resonator 600 as a resonation device according to a sixth embodiment, and FIG.", "10A is a plan view and FIG.", "10B is a sectional view taken along line H-H of FIG.", "10A.", "FIG.", "11 is a diagram illustrating a relationship between Lb/Wb and a hysteresis of the crystal resonator 600.FIGS.", "12A and 12B are schematic configuration diagrams of an oscillator resonator according to a seventh embodiment, and FIG.", "12A is a plan view and FIG.", "12B is a sectional view taken along line J-J of FIG.", "12A.", "FIG.", "13 is a perspective view illustrating a configuration of a mobile-type (or a note book-type) personal computer as an electronic apparatus according to an eighth embodiment.", "FIG.", "14 is a perspective view illustrating a mobile phone as the electronic apparatus according to the eighth embodiment.", "FIG.", "15 is a perspective view illustrating a digital camera as the electronic apparatus according to the eighth embodiment.", "FIG.", "16 is a perspective view illustrating an automobile as a moving object according to a ninth embodiment.", "DESCRIPTION OF EXEMPLARY EMBODIMENTS Hereinafter, the embodiment of the invention will be described with reference to the drawings.", "Further, in the following drawings, in order to make the magnitude of the respective layers and members recognizable, there is a case of making the scale of the respective layers and members different from that in the actual structure.", "First Embodiment A crystal resonator 100 as an example of a resonation device according to the embodiment will be described.", "The crystal resonator 100 is a resonation device which oscillates at a predetermined frequency by a predetermined AC voltage applied from the outside.", "Crystal Resonator First, a schematic configuration of the crystal resonator 100 as the resonation device according to the first embodiment will be described.", "FIGS.", "1A and 1B are schematic configuration diagrams of the crystal resonator 100 as the resonation device of the first embodiment, and FIG.", "1A is a plan view and FIG.", "1B is a sectional view taken along line A-A of FIG.", "1A.", "The crystal resonator 100 is provided with a resonator element 10, a package 20, a first bonding member 41, a second bonding member 42, a lid (a lid body) 30, and the like.", "Note that, for the sake of convenience of description, the lid 30 is not shown in FIG.", "1A.", "In addition, in the following description, an upper side in FIG.", "1B is referred to as “up” and a lower side is referred to as “down”, and a surface on the upper side of each member in FIG.", "1B is referred to as an upper surface, and a surface on the lower side is referred to as a lower surface.", "Resonator Element The resonator element 10 is provided with a crystal substrate 11 formed of a crystal which is a type of piezoelectric single crystal, excitation electrodes 12a and 13a, extracting electrodes 12b and 13b, and connection electrodes 12c and 13c.", "The resonator element 10 resonates at a predetermined resonance frequency by applying a predetermined AC voltage to the excitation electrodes 12a and 13a.", "The crystal substrate 11 includes an upper surface 11a and a lower surface 11b which are respectively the front surface and the rear surface, and a first side 11e.", "The excitation electrode 12a and the extracting electrode 12b are formed on the upper surface 11a of the crystal substrate 11.The excitation electrode 13a, the extracting electrode 13b, and the connection electrodes 12c and 13c are formed on the lower surface 11b of the crystal substrate 11.In addition, the connection electrodes 12c and 13c are arranged close to the first side 11e of the lower surface 11b of the crystal substrate 11 in the first direction 54.The extracting electrode 12b extends from the excitation electrode 12a to the connection electrode 12c via side surface which connects the upper surface 11a and the lower surface 11b, and electrically connects the excitation electrode 12a and the connection electrode 12c.", "The extracting electrode 13b extends from the excitation electrode 13a to the connection electrode 13c, and electrically connects the excitation electrode 13a and the connection electrode 13c.", "The excitation electrodes 12a and 13a are formed into a rectangular shape in a planar view, that is, when viewed from above, and are disposed so as to substantially overlap with each other in such a manner that the center of the excitation electrode 12a and the center of the excitation electrode 13a substantially overlap with each other.", "In addition, the crystal substrate 11 includes a resonation area 11c which is interposed between the excitation electrodes 12a and 13a.", "Here, the center of each of the excitation electrodes 12a and 13a is the centroid (the center of a drawing) of the shape when the respective excitation electrodes 12a and 13a are viewed from above.", "In the embodiment, the excitation electrodes 12a and 13a are disposed in such a manner that the center of the excitation electrode 12a and the center of the excitation electrode 13a substantially overlap with each other; however, it is not limited thereto as long as the excitation electrode 12a and the excitation electrode 13a overlap with each other when viewed from above and have the resonation area 11c.", "In addition, the excitation electrodes 12a and 13a may be formed into a polygonal shape such as a circular shape, an elliptical shape, and a triangular shape, or may be formed into a polygonal shape having a rounded corner, in addition to the rectangular shape.", "The excitation electrodes 12a and 13a, the extracting electrodes 12b and 13b, and the connection electrodes 12c and 13c are formed through a method such as a vapor deposition method, a sputtering method, and a plating method, or through a method of volatilizing a solvent component other than metal after performing the coating with a paste (a solvent) including a metallic member.", "In addition, the excitation electrodes 12a and 13a, the extracting electrodes 12b and 13b, and the connection electrodes 12c and 13c are configured to have at least two layers of a base layer and an upper layer.", "Examples of a configuration material for the base layer include an adhesion material with respect to the crystal substrate 11, and specifically, a metallic element such as chromium (Cr), nickel (Ni), titanium (Ti), and tungsten (W), a mixture including one or two or more the metallic elements, or an alloy can be used.", "On the other hand, examples of a material for the upper layer include a configuration material having particularly high electrical conduction properties, and specifically, a metallic element such as gold (Au), platinum (Pt), silver (Ag), aluminum (Al), and copper (Cu), a mixture including one or two or more the metallic elements, or an alloy can be used.", "Note that, the excitation electrodes 12a and 13a, the extracting electrodes 12b and 13b, and the connection electrodes 12c and 13c may be configured to have one layer, for example, may be configured to have a metallic element such as gold (Au), platinum (Pt), silver (Ag), aluminum (Al), and copper (Cu), a mixture including one or two or more the metallic elements, or an alloy.", "The resonation area 11c includes a resonation area center 11d.", "In the embodiment, the excitation electrodes 12a and 13a are formed into a rectangular shape and are disposed so as to substantially overlap with each other when viewed from above, and thus the resonation area 11c is formed into a rectangular shape and the resonation area center 11d and the center of each of the excitation electrodes 12a and 13a substantially overlap with each other when viewed from above.", "Here, the resonation area center 11d is the centroid (the center of a drawing) of the shape when the resonation area 11c is viewed from above.", "Package The package 20 is provided with a bottom plate 21 as a substrate, a side wall 22, a seal ring 23, and the like, and the bottom plate 21 includes an upper surface 21a and a lower surface 21b.", "Specifically, in the package 20, an inner space 26 (an accommodating space) of which the center portion is depressed by stacking the side wall 22 on a peripheral portion of the upper surface 21a on the bottom plate 21, and the resonator element 10 is accommodated in the inner space 26.The outer shape of the package 20 is not limited, for example, it may be a rectangular parallelepiped shape, a cylindrical shape, or the like.", "The bottom plate 21 and the side wall 22 are preferably formed of a material having the same or approximate coefficient of thermal expansion as that of the resonator element 10 and the lid 30, and ceramics are used in the embodiment.", "The seal ring 23 serves as a bonding material which bonds the side wall 22 and the lid 30, is formed of, for example, a metallic brazing material such as a gold brazing material and a silver brazing material, or metal such as glass or kovar, and is provided in a frame shape along the upper surface of the side wall 22.In addition, the internal connection terminals 24a and 24b are formed on the upper surface 21a of the bottom plate 21, and a plurality of external connection terminals 25 which are electrically connected to at least an outer circuit and a mount substrate of the crystal resonator 100 are formed on the lower surface 21b of the bottom plate 21.The internal connection terminals 24a and 24b and the plurality of external connection terminals 25 are obtained through sequential steps of, for example, tungsten metalizing, nickel-plating, and gold-plating.", "The internal connection terminals 24a and 24b are electrically connected to two external connection terminals 25 which are different from each other in the plurality of external connection terminals 25 via a wiring (not shown) which is disposed on the bottom plate 21.In addition, the plurality of external connection terminals 25 are electrodes which are used to supply an AC voltage to the resonator element 10 and output an electrical signal such as a frequency by being electrically connected to at least the external mount substrate (not shown).", "Lid The lid 30 is formed into a flat plate-like shape which covers an opening of the package 20, and formed of metal such as kovar and 42 alloy, ceramics, glass and the like.", "The lid 30 is bonded to the seal ring 23 such that the inner space 26 is in an air-tight state, after the resonator element 10 is accommodated in the inner space 26 of the package 20.An inner pressure of the inner space 26 which is in the air-tight state is set to be a predetermined pressure.", "For example, when the inner space 26 is in a vacuum state (a state where a pressure is lower than an atmospheric pressure (1×105 Pa to 1×10−10 Pa (JIS Z 8126-1: 1999))) or in the same pressure state as the atmospheric pressure by being filled with an inert gas such as nitrogen or argon.", "Therefore, the resonator element 10 can continuously and stably resonate.", "In addition, the inner space 26 in the embodiment is tightly sealed in a vacuum state.", "When the inner space 26 is tightly sealed in the vacuum state, a Q value of the accommodated resonator element 10 is increased, and thus the resonator element 10 can continuously and stably resonate.", "Bonding Member The first bonding member 41 and the second bonding member 42 are arranged in the direction in which the first side 11e of the lower surface 11b on the crystal substrate 11 extends.", "The first bonding member 41 and the second bonding member 42 are formed of a resin containing a conductive member, for example, an electroconductive adhesive.", "Examples of the conductive member include a metallic element such as gold (Au), silver (Ag), copper (Cu), aluminum (Al), and platinum (Pt), a mixture such as a metallic fine particle including one or two or more the metallic elements, a resin fine particle obtained by plating the aforementioned metallic elements, and a carbon fine particle.", "Examples of the resin include an epoxy-based resin, a silicon-based resin, a polyimide-based resin, a polyamide-based resin, or an acrylic resin.", "The first bonding member 41 is electrically and mechanically connected to the connection electrode 12c, and is electrically and mechanically connected to an internal connection terminal 24a.", "The second bonding member 42 is electrically and mechanically connected to the connection electrode 13c, and is electrically and mechanically connected to an internal connection terminal 24b.", "In other words, the resonator element 10 is supported by the bottom plate 21 via the first bonding member 41 and the internal connection terminal 24a, and the second bonding member 42 and the internal connection terminal 24b.", "That is, when viewed from above, the resonator element 10 does not come in contact with the bottom plate 21, the side wall 22, the seal ring 23, and the lid 30 but is cantilever-supported by the bottom plate 21 in an area close to a side that the first side 11e faces with the excitation electrodes 12a and 13a interposed therebetween.", "Since the first bonding member 41 and the second bonding member 42 have conductivity, a mechanical bonding and an electrical bonding can be concurrently performed between the connection electrode 12c and the internal connection terminal 24a, and between the connection electrode 13c and the internal connection terminal 24b.", "Accordingly, it is possible to reduce the number of members used for the resonation device compared with a case where the mechanical bonding and the electrical bonding which are performed between the resonator element 10 and the bottom plate 21 by using different members, and thus it is possible to efficiently manufacture the crystal resonator 100.A first bonding center 41b is positioned on the connection electrode 12c side of the first bonding member 41, that is, an upper surface 41a on the resonator element 10 side.", "A second bonding center 42b is positioned on the connection electrode 13c side of the second bonding member 42, that is, an upper surface 42a on the resonator element 10 side.", "Each of the first bonding center 41b and the second bonding center 42b has a shape when the first bonding member 41 and the second bonding member 42 are viewed from above, that is, the centroid (the center of a drawing) of the shape when the upper surface 41a and the upper surface 42a are viewed from above.", "Next, a relationship between the resonation area 11c, the first bonding member 41, and the second bonding member 42 will be described.", "First, a virtual line which passes through the first bonding center 41b and the second bonding center 42b is set to be a first virtual line 51, a virtual line which passes through the resonation area center 11d and perpendicular to a first virtual line 51 is set to be a second virtual line 52.In addition, an intersection 53 of the first virtual line 51 and the second virtual line 52 is disposed between the first bonding center 41b and the second bonding center 42b.", "That is, the first bonding member 41 and the second bonding member 42 are arranged in the first direction 54 which is the direction in which the first side 11e extends while interposing the second virtual line 52 therebetween when viewed from above.", "Here, when a distance between the first bonding center 41b and the second bonding center 42b is set to be L1, and a length of perpendicular line drawn to a virtual line which connects the first bonding center 41b and a second bonding center 42b from the resonation area center 11d is set to be L2, that is, a distance between the resonation area center 11d and the intersection 53 is set to be L2, a relationship between the aforementioned L1 and L2 and a hysteresis will be described below.", "First, the hysteresis of the crystal resonator 100 will be described.", "Regarding a resonance frequency of the resonator element 10, a resonance frequency at a predetermined temperature T in a process in which an ambient temperature of the crystal resonator 100 is increased, and a resonance frequency at a predetermined temperature T in a process in which an ambient temperature of the crystal resonator 100 is decreased have different characteristics from each other.", "Having different characteristics depending on the time the ambient temperature is increased or decreased means to have the hysteresis.", "The reason for this is as follows.", "Since the crystal resonator 100 according to the embodiment is formed of a different material from that of the resonator element 10 and the bottom plate 21, it has a different coefficient of thermal expansion, and thus an elongation amount or a shrinkage amount of the resonator element 10, and an elongation amount or a shrinkage amount the bottom plate 21 in accordance with a change of the ambient temperature of the crystal resonator 100 are different from each other.", "Accordingly, when the ambient temperature of the crystal resonator 100 is changed, a stress is generated in the resonator element 10 due to a difference between the elongation amount or the shrinkage amount of the resonator element 10 and the elongation amount or the shrinkage amount of the bottom plate 21.In addition, when the resonator element 10 is bonded to the inside of the crystal resonator 100, that is, the inside of the package 20 via the first bonding member 41 and the second bonding member 42, the change of the ambient temperature of the crystal resonator 100 is slowly transferred to the resonator element 10 compared with the bottom plate 21.That is, in the process in which the ambient temperature of the crystal resonator 100 is increased, the temperature of the resonator element 10 is lower than a predetermined temperature T even when the ambient temperature of the crystal resonator 100 becomes a predetermined temperature T, and in the process in which the ambient temperature of the crystal resonator 100 is decreased, the temperature of the resonator element 10 is higher than a predetermined temperature T even when the ambient temperature of the crystal resonator 100 becomes a predetermined temperature T. From the above description, even when the ambient temperature of the crystal resonator 100 is a predetermined temperature T, the temperature of the resonator element 10 is differentiated depending on the process in which the ambient temperature is increased or the process in which the ambient temperature is decreased, and thus the elongation amount or the shrinkage amount of the resonator element 10 is differentiated.", "Accordingly, the stress is generated in the resonator element 10 due to the difference between the elongation amount or the shrinkage amount of the resonator element 10 and the elongation amount or the shrinkage amount of the bottom plate 21, and the stress generated in a case where the ambient temperature becomes a predetermined temperature T in the process in which the ambient temperature of the crystal resonator 100 is increased is different from the stress generated in a case where the ambient temperature becomes a predetermined temperature T in the process in which the ambient temperature is decreased.", "Further, it is known that the resonance frequency of the resonator element 10 when a predetermined AC voltage is applied to the resonator element 10 is changed due to a stress applied to the resonator element 10.Accordingly, regarding the resonance frequency of the crystal resonator 100 including the resonator element 10, the resonance frequency at the temperature T in the process in which the ambient temperature of the crystal resonator 100 is increased is different from the resonance frequency at the temperature T in the process in which the ambient temperature of the crystal resonator 100 is decreased, and this phenomenon is called a characteristic of the hysteresis or the hysteresis.", "The reason why the resonance frequency of the resonator element 10 is changed when the stress is applied to the resonator element 10 is that the stress is also applied to the resonation area 11c in which a large amount of resonation energy is concentrated in a state where the resonator element 10 resonates, and then the distribution of the resonation energy in the resonation area 11c is changed.", "In addition, in a case where the stress is applied to the entire resonation area 11c, that is, as a range of the area to which the stress is applied is spread in the resonation area 11c, the distribution of the resonation energy in the resonation area 11c is affected compared with a case where the stress is applied to a portion in the resonation area 11c, and therefore, it is considered that an amount of change in the resonance frequency of the resonator element 10 becomes larger.", "From above description, it is considered that when reducing the stress, which is generated by the difference between the elongation amount or the shrinkage amount of the resonator element 10 and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature of the crystal resonator 100, so as not to be transferred to the resonation area 11c, it is possible to reduce the change of the resonance frequency of the resonator element 10.In this regard, the inventors of the present application have studied regarding a relationship between the resonation area 11c, the first bonding member 41 and the second bonding member 42, and the stress distribution in the resonator element 10.FIGS.", "2A and 2B and FIGS.", "3A and 3B are diagrams illustrating the stress applied to the resonator element 10 when the ambient temperature becomes a predetermined temperature T in the process in which the ambient temperature of the crystal resonator is increased or decreased.", "FIG.", "2A is a diagram illustrating a deflection of the resonator element 10 when viewed from a sectional direction along the first virtual line 51 in a case where the ambient temperature becomes a predetermined temperature T in the process in which the ambient temperature of the crystal resonator 100a is decreased in a crystal resonator 100a which satisfies a relationship expressed by L1=W1 in FIGS.", "1A and 1B, and FIG.", "2B is a diagram illustrating a deflection of the resonator element 10 when viewed from a sectional direction along the first virtual line in a case where the ambient temperature becomes a predetermined temperature T in the process in which the ambient temperature of the crystal resonator 100b is decreased in the crystal resonator 100b which satisfies a relationship expressed by L1=W2 in FIGS.", "1A and 1B.", "Note that, W1 and W2 satisfy a relationship expressed by W1>W2.In addition, the crystal resonator 100a and the crystal resonator 100b have the same distance L2 between the intersection 53 and the resonation area center 11d.", "FIG.", "3A is a sectional view along the second virtual line 52 in FIG.", "1A.", "FIG.", "3B is a schematic view illustrating the stress distribution in the resonator element 10 in the direction in which the second virtual line 52 extends when the ambient temperature becomes a predetermined temperature T, in the crystal resonator 100a in FIG.", "2A and the crystal resonator 100b in FIG.", "2B, and Sa represents the stress distribution in the resonator element 10 in the crystal resonator 100a and Sb represents the stress distribution in the resonator element 10 in the crystal resonator 100b.", "In addition, in FIG.", "3B, a vertical axis represents an absolute value of the stress S [N/m2], and a horizontal axis represents a distance D [mm] from the intersection 53.In addition, in FIGS.", "3A and 3B, a distance between the intersection 53 and an end portion 55, which is close to the first virtual line 51 side with respect to the resonation area center 11d, in the resonation area 11c is set to be d1, a distance between the first virtual line 51 and the resonation area center 11d is set to be d2, and a distance between the intersection 53 and an end portion 56, which is close to the side opposite to the first virtual line 51 with respect to the resonation area center 11d, in the resonation area 11c is set to be d3.Note that, for the sake of convenience of description, the side wall 22, the seal ring 23, and the external connection terminal 25 are not illustrated in FIGS.", "2A and 2B, and FIG.", "3A.", "In addition, in each of the crystal resonators 100a and 100b, the excitation electrodes 12a and 13a are disposed in the same way in the resonator element 10.As described in the above-mentioned hysteresis, the ambient temperatures of the crystal resonators 100a and 100b are changed, a difference in the temperature between the resonator element 10 and the bottom plate 21 occurs due to a difference in heat transmission.", "For example, when the ambient temperature becomes a predetermined temperature T in the process in which the ambient temperatures of the crystal resonators 100a and 100b are decreased, even when the temperature of the bottom plate 21 becomes a predetermined temperature T, the temperature of the resonator element 10 is higher than a predetermined temperature T. For this reason, for example, in a case where the resonator element 10 and the bottom plate 21 have the same value of positive coefficient of thermal expansion, the temperature of the resonator element 10 is higher than the temperature of the bottom plate 21 in a predetermined temperature T, and thus the elongation amount of the resonator element 10 is larger than elongation amount of the bottom plate 21.Therefore, the resonator element 10 is deflected in the thickness direction.", "FIGS.", "2A and 2B illustrate the deflection of the resonator element 10 when the ambient temperature becomes a predetermined temperature T in the process in which the ambient temperatures of the crystal resonators 100a and 100b are decreased.", "From FIGS.", "2A and 2B, it is found that regarding the deflection occurred in the resonator element 10, deflection 62 occurred in the crystal resonator 100b which satisfies the relationship expressed by L1=W2 in FIG.", "2B is smaller than deflection 61 occurred in the crystal resonator 100a which satisfies the relationship expressed by L1=W1 in FIG.", "2A.", "The reason for this is that regarding the distance L1 between the first bonding center 41b and the second bonding center 42b, which is an interval of the bonding member supporting the resonator element 10, the distance W2 in the crystal resonator 100b is shorter than the distance W1 in the crystal resonator 100a, and thus the absolute value of the difference between the elongation amount or the shrinkage amount of the resonator element 10 and the elongation amount or the shrinkage amount of the bottom plate 21 is reduced.", "FIG.", "3B is a schematic view illustrating the distribution of the stress generated in the resonator element 10 due to the deflection illustrated in FIGS.", "2A and 2B, in the direction in which the second virtual line 52 extends in a sectional portion of FIG.", "3A.", "From FIG.", "3B, it is found that regarding the distribution of the stress generated in the resonator element 10, Sa and Sb become the maximum values when satisfying a relationship expressed by D=0, and the respective values thereof are Sa0 and Sb0.In addition, the stress applied to each of Sa and Sb is reduced as the distance D from the intersection 53 becomes longer.", "Further, regarding the distribution of the stress in the resonator element 10, Sb is rapidly reduced compared with Sa as the distance D from the intersection 53 becomes longer.", "Further, in FIG.", "3B, Sb is reduced compared with Sa in the entire range of D=d1, D=d2, and D=d3.That is, the distribution of the stress generated in the resonation area 11c of the crystal resonator 100b which satisfies the relationship expressed by L1=W2 becomes smaller than the distribution of the stress generated in the resonation area 11c of the crystal resonator 100a which satisfies the relationship expressed by L1=W1.As described above, the stress distribution in the resonator element 10 changes in accordance with the distance L1 between the first bonding center 41b and the second bonding center 42b, and in a case where the distance L1 is short the stress applied into the resonation area 11c can be reduced compared with a case where the distance L1 is long.", "However, in some cases, the stress applied into the resonation area 11c cannot be reduced only by defining the length of the distance L1.The reason for this is that the distance L2 between the resonation area center 11d and the intersection 53 can be flexibly set as long as the excitation electrode 13a does not directly come in contact with the first bonding member 41 and the second bonding member 42, and thus the resonation area 11c is disposed in the area in which the great stress is generated.", "The crystal resonator 100b in FIG.", "2A to FIG.", "3B satisfy the relationship expressed by L2=d2, for example, it is possible to set a value of the distance L2 in the crystal resonator 100b to be shorter than the distance d2 as long as the excitation electrode 13a does not directly come in contact with the first bonding member 41 and the second bonding member 42, and in a case where the distance L2 is shorter than the distance d2, the distribution of the stress in the resonation area 11c becomes larger than a case of satisfying the relationship expressed by L2=d2.Note that, the same is true for a case of the crystal resonator 100a.", "From the above description, it is considered that the stress distribution in the resonation area 11c is not related to the absolute value of each of the distance L1 between the first bonding center 41b and the second bonding center 42b and the distance L2 between the resonation area center 11d and the intersection 53, but is related to a ratio of L1 to L2.As described above, it is considered that the crystal resonator 100 including the resonator element 10 has the hysteresis in response to stress applied to the resonator element 10, and a positional relationship between the first bonding member 41 and the second bonding member 42, and the resonation area 11c is important so as to reduce the hysteresis of the crystal resonator 100.Accordingly, the inventors of the present application have obtained a result illustrated in FIGS.", "3A and 3B by executing an experiment based on the assumption that the hysteresis of the crystal resonator 100 is related to L1/L2 which is the ratio of the distance L1 between the first bonding center 41b and the second bonding center 42b and the distance L2 between the resonation area center 11d and the intersection 53.The resonator element 10 which is used in the aforementioned experiment is formed into a rectangular shape having a short side of 1.25 mm in the first direction 54 and a long side of 1.80 mm in the direction which intersects with the first direction 54 as illustrated in FIG.", "1A.", "When viewed from above, the excitation electrodes 12a and 13a are formed into a rectangular shape and are disposed so as to substantially overlap with each other, the short side is disposed in the direction along the short side of the resonator element 10, and the long side is disposed in the direction along the long side of the resonator element 10.The excitation electrodes 12a and 13a are formed into a rectangular having a short side of 0.90 mm and a long side of 1.08 mm.", "The center of the resonator element 10 and the center of the respective excitation electrodes 12a and 13a substantially overlap the first virtual line 51.The resonation area 11c substantially overlaps the center of the each of the excitation electrodes 12a and 13a when viewed from above, and thus the resonation area 11c is disposed substantially in the same position as that of the excitation electrodes 12a and 13a with the same scale.", "The first bonding center 41b and the second bonding center 42b are arranged in the direction along the first side 11e and the distance between the first bonding center 41b and the first side 11e and the distance between the second bonding center 42b and the first side 11e are 0.175 mm when viewed from above.", "In addition, the resonator element 10, the excitation electrodes 12a and 13a, and the resonation area 11c are disposed to be substantially line symmetry with respect to the second virtual line 52 when viewed from above, and the distance between the resonation area center 11d and the intersection 53 is 0.825 mm.", "In addition, in the experiment of the embodiment, the upper surface 41a of the first bonding member 41 and the upper surface 42a of the second bonding member 42 are respectively a circle having a diameter of 0.35 mm centering the first bonding center 41b and a circle having a diameter of 0.35 mm centering the second bonding center 42b.", "In addition, in the experiment, the value of L1/L2 is changed by setting the distance L2 between the resonation area center 11d and the intersection 53 to be substantially constant and changing the distance L1 between the first bonding center 41b and the second bonding center 42b.", "FIG.", "4 is a diagram illustrating a relationship between L1/L2 and the hysteresis of the crystal resonator 100.Here, as described later, the hysteresis is the maximum value of the absolute value of the difference between the resonance frequency when the temperature is decreased and the resonance frequency when the temperature is increased in each temperature, which is acquired by measuring the resonance frequency of the crystal resonator 100 in each temperature when the temperature is decreased and the resonance frequency of the crystal resonator 100 in each temperature when the temperature is increased.", "In addition, in FIG.", "4, the hysteresis of the crystal resonator 100 is measured and acquired in the following manner.", "In the experiment, the hysteresises of the crystal resonator 100 having five types of ratios of L1/L2 which are 0.36, 0.50, 0.70, 0.80, and 0.90 are measured and acquired.", "In the experiment, the hysteresis of the crystal resonator 100 is measured and acquired through the following methods.", "First, the ambient temperature of the crystal resonator 100 is increased from room temperature (+25° C.) up to +85° C. Then, the resonance frequency of the crystal resonator 100 is measured at a 5° C. of temperature interval when the temperature is decreased by decreasing the ambient temperature of the crystal resonator 100 from +85° C. up to −40° C. Next, by heating the crystal resonator 100 such that the ambient temperature is increased from −40° C. up to +85° C., when the temperature is increased, the resonance frequency of the crystal resonator 100 is measured at a temperature at which the resonance frequency is measured when the temperature is decreased.", "Then, a frequency difference, which is the difference between the resonance frequency when the temperature is decreased and the resonance frequency when the temperature is increased, is acquired with respect to the resonance frequencies of the crystal resonator 100 which are measured when the temperature is decreased and increased under the same temperature condition.", "Subsequently, the frequency difference obtained under the respective temperature conditions is normalized by a norminal frequency (the resonance frequency at room temperature (+25° C.)) of the crystal resonator 100, and then the normalized frequencies under the respective temperature conditions are acquired.", "Lastly, a value of which the absolute value becomes the maximum is acquired among the normalized frequencies under the respective temperature conditions, and the acquired value is extracted as the hysteresis of the crystal resonator 100.The hysteresises of the crystal resonator 100 in each of ratios of L1/L2 is calculated by performing the above measurement on the crystal resonator 100 having the five types of ratios of L1/L2 which are used in the experiment.", "From FIG.", "4, it is found that when L1/L2 which is the ratio of the distance L1 between the first bonding center 41b and the second bonding center 42b, and the distance L2 between the resonation area center 11d and the intersection 53 is 0.97, the hysteresis of the crystal resonator 100 is 0.07 ppm.", "In addition, from FIG.", "4, it is found that when a value smaller than 0.36 is input to the ratio of L1/L2, the hysteresis of the crystal resonator 100 becomes further smaller.", "Accordingly, in a range of 0<L1/L2≤0.97, the hysteresis of the crystal resonator 100 is 0.07 ppm or less.", "In addition, when L1/L2=0.85 is satisfied, the hysteresis of the crystal resonator 100 becomes 0.05 ppm.", "Accordingly, in a range of 0<L1/L2≤0.85, the hysteresis of the crystal resonator 100 is 0.05 ppm or less.", "In a case where the crystal resonator 100 or an oscillator which uses the crystal resonator 100 is used for a product such as an electronic apparatus as a reference frequency source, the absolute value of the hysteresis of the crystal resonator 100 is required to be small so as not to reduce performance of the electronic apparatus.", "Particularly, in a case where the crystal resonator 100 or the oscillator which uses the crystal resonator 100 is used for, for example, a reference frequency source of a femtocell base station of a mobile phone and the like, the variation in the frequency-temperature characteristics of the crystal resonator 100 or the oscillator which uses the crystal resonator 100 is required to be 0.25 ppm or less, and in order to satisfy this value, the hysteresis is required to be 0.1 ppm or less.", "Accordingly, the hysteresis of the oscillator which uses the crystal resonator 100 and the crystal resonator 100 is preferably 0.07 ppm or less.", "In addition, in a case where the crystal resonator 100 or the oscillator which uses the crystal resonator 100 is used for the electronic apparatus requiring higher frequency accuracy, for example, a device which is synchronized with a GPS signal, a macrocell base station of a mobile phone, a base station device for optical network (a basic system) and the like, the hysteresis of the crystal resonator 100 or the oscillator which uses the crystal resonator 100 is preferably 0.05 ppm or less.", "As described above, according to the crystal resonator 100 in the embodiment, it is possible to obtain the following effects.", "In the crystal resonator 100, for example, even in a case where the stress is generated due to a difference between the elongation amount or the shrinkage amount of the resonator element 10 and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature of the crystal resonator 100, L1/L2 satisfies a relationship expressed by 0<L1/L2≤0.97, and thus it is possible to reduce the stress so as not to be transferred to the resonation area 11c of the resonator element 10.As a result, it is possible to reduce the variation in characteristics of the crystal resonator 100, for example, the value of hysteresis.", "In addition, in the crystal resonator 100, for example, even in a case where the stress is generated due to a difference between the elongation amount or the shrinkage amount of the resonator element 10 and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature of the crystal resonator 100, L1/L2 satisfies a relationship expressed by 0<L1/L2≤0.85 and thus it is possible to further reduce the stress so as not to be transferred to the resonation area 11c of the resonator element 10.As a result, it is possible to further reduce the variation in characteristics of the crystal resonator 100, for example, the value of hysteresis compared with the case where L1/L2 satisfies the relationship expressed by 0<L1/L2≤0.97.Meanwhile, in the experiment, the diameter of each of the upper surface 41a of the first bonding member 41 and the upper surface 42a of the second bonding member 42 is 0.35 mm, and thus as a lower limit of the distance L1 is preferably greater than 0.35 mm which is in a range that the first bonding member 41 and the second bonding member 42 are not electrically connected to each other.", "That is, it is preferable that L1/L2 satisfies a relationship expressed by 0.425<L1/L2≤0.97.Further, in a case where the first bonding member and the second bonding member 42 are formed of an electroconductive adhesive, the diameter of each of the upper surface 41a of the first bonding member 41 and the upper surface 42a of the second bonding member 42 can be 0.15 mm or smaller, and thus as a lower limit of the distance L1 is preferably greater than 0.15 mm which is in a range that the first bonding member 41 and the second bonding member 42 are not electrically connected to each other.", "That is, it is preferable that L1/L2 satisfies a relationship expressed by 0.185<L1/L2≤0.97.In addition, the measurement of the resonance frequency when the ambient temperature of the crystal resonator 100 is decreased is performed first in the experiment; however, the order of measurement is not limited, for example, the measurement of the resonance frequency when the ambient temperature of the crystal resonator 100 is increased may be performed first.", "In addition, the measurement may be not necessarily performed at the 5° C. of temperature interval as long as the hysteresis can be calculated, for example, the temperature interval may be in a range of 0.5° C. to 10° C. Further, the room temperature is set to be +25° C. in the experiment; however, room temperature may be, for example, in a range of 0° C. to +40° C. In addition, in the embodiment, the crystal substrate 11 is used as the resonator element 10; however, the resonator element 10 may be formed of another piezoelectric single crystal such as lithium niobate and lithium tantalite.", "In a case where the resonator element 10 is formed of a piezoelectric single crystal other than the crystal, the orientation of crystal (a cut angle) or the like is selected so as to obtain the same characteristics as in the case of being formed of the crystal.", "An elastic surface wave element and a MEMS resonator element other than the piezoelectric resonator element can be used for the resonator element 10.In addition, the resonator element 10 may be formed of a piezoelectric material of piezoelectric ceramics such as lead zirconate titanate, or a silicon substrate other than the piezoelectric single crystal.", "Further, the shape of the resonator element 10 is not particularly limited, for example, it may be a bipod tuning fork, an H-type tuning fork, a tripod tuning fork, a comb type, an orthogonal type, a prismatic type or the like.", "As means for resonating the resonator element 10, a substance obtained by a piezoelectric effect or an electrostatic drive by coulomb force may be used.", "In addition, the resonator element 10 may be an element for detecting the physical quantity, for example, an element for an inertial sensor (an acceleration sensor, a gyro sensor, and the like), and a force sensor (a tilt sensor and the like).", "In addition, the shapes and the sizes of the resonator element 10, and the excitation electrodes 12a and 13a may be variously modified without being limited to the shapes of the sizes which are used in the experiment.", "Further, the shapes and the sizes of the upper surface 41a of the first bonding member 41 and the upper surface 42a of the second bonding member 42 may be variously modified without being limited to the shapes and the sizes which are used in the experiment.", "In addition, the first bonding member 41 and the second bonding member 42 use the conductive member in the embodiment; however, at least one of the first bonding member 41 and the second bonding member 42 may be a non-conductive member, for example, a resin or glass which does not contain a conductive member.", "In a case where the first bonding member 41 and the second bonding member 42 are non-conductive members, for example, the resonator element 10 is mechanically supported by the bottom plate 21 via the first bonding member 41 and the second bonding member 42, and the excitation electrode 12a and the internal connection terminal 24a, and the excitation electrode 13a and the internal connection terminal 24b can be electrically connected to each other via the conductive member such as a bonding wire.", "In addition, even in a case where one of the first bonding member 41 and the second bonding member 42 is a conductive member and the other one is a non-conductive member, it is possible to perform the mechanical and electrical connection on the bonding member side of the non-conductive member in the same way as above and to perform the mechanical and electrical connection on the bonding member side of the conductive member in the same way as in the first embodiment.", "As described above, even when the non-conductive member is used as at least one of the first bonding member 41 and the second bonding member 42, it is possible to obtain some effects of the first embodiment.", "That is, even when the non-conductive member is used as at least one of the first bonding member 41 and the second bonding member 42, the resonator element 10 is mechanically connected to the bottom plate 21 via the first bonding member 41 and the second bonding member 42.Accordingly, when the resonation area 11c, the first bonding member 41, and the second bonding member 42 satisfy the relationship expressed by 0<L1/L2≤0.97, it is possible to reduce the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element 10 and the elongation amount or the shrinkage amount of the bottom plate 21, so as not to be transferred to the resonation area 11c of the resonator element 10 in accordance with the change of the ambient temperature of the crystal resonator 100.As a result, it is possible to reduce the variation in characteristics of the crystal resonator 100, for example, the value of the hysteresis.", "Further, in the present embodiment, the crystal resonator 100 including the resonator element 10 is exemplified as an example of the resonation device; however, it is possible to employ various types of the resonation devices.", "The resonation device may be a sensor such as an inertial sensor (an acceleration sensor, a gyro sensor, and the like) and a force sensor (a tilt sensor and the like), which includes an element for detecting the physical quantity, a detection circuit for detecting a signal from the element, or an oscillation circuit for oscillating the element.", "The aforementioned oscillation circuit and detection circuit may be disposed, for example, on the inner space 26 side of the bottom plate 21, or may be disposed on the side, on which the plurality of external connection terminals 25 are formed, of the bottom plate 21.In addition, The aforementioned oscillation circuit and detection circuit are disposed on the side separated from the resonation device, and thus may be electrically connected to the resonator element 10 via the plurality of external connection terminals 25 of the resonation device.", "Second Embodiment As an example of the resonation device according to the second embodiment, a crystal resonator 200 will be described.", "Note that, the same constituent element as in the crystal resonator 100 in the first embodiment is given the same reference numerals, repeated description will be omitted, and the description will focus on the differences from the crystal resonator 100 in the first embodiment.", "FIGS.", "5A and 5B are schematic configuration diagrams of the crystal resonator 200 as the resonation device according to the second embodiment, and FIG.", "5A is a plan view and FIG.", "5B is a sectional view taken along line B-B of FIG.", "5A.", "Resonator Element As illustrated in FIGS.", "5A and 5B, unlike the first embodiment, a resonator element 110 of the crystal resonator 200 includes a hollow 111f, which is on a lower surface 111b side of a crystal substrate 111 being formed, between the first virtual line 51 which connects the first bonding center 41b and the second bonding center 42b and an excitation electrode 113a on the lower surface 111b when viewed from above.", "In addition, the hollow 111f extends to the second bonding center 42b from the first bonding center 41b in the direction along the first direction 54.In the hollow 111f, a distance in a direction which intersects with an upper surface 111a and the lower surface 111b of the crystal substrate 111, that is, a thickness T1 of the hollow 111f is smaller than a thickness T2 of the crystal substrate 111 in which the hollow 111f is not formed.", "In addition, the hollow 111f is formed in the inside further than an end portion of the crystal substrate 111 in the first direction 54 when viewed from above.", "In the crystal resonator 200 in the embodiment, the stress which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element 110 and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature of the crystal resonator 200 is transferred to a resonation area 111c of the resonator element 110, that is, the stress is transferred to the resonation area 111c which is an area which overlaps excitation electrodes 112a and 113a in the crystal substrate 111 of FIG.", "5A, and a hatched area in the crystal substrate 111 of FIG.", "5B via an area in the hollow 111f.", "The thickness T1 of the hollow 111f on the crystal substrate 111 is smaller than the thickness T2 of the crystal substrate 111.In a case where the stress is transferred to the area in the thickness T2 via the area in the thickness T1, the stress is absorbed into the area in the thickness T1 which is largely distorted compared with the area in the thickness T2, and thus the stress transferred to the area in the thickness T2 is reduced.", "Accordingly, the stress which is generated due to the difference between the elongation amount or the shrinkage amount the resonator element 110 and the elongation amount or the shrinkage amount of the bottom plate 21 as the substrate in accordance with the change of the ambient temperature of the crystal resonator 200 is less likely to be transferred to the resonation area 111c by distorting the hollow 111f.", "As described above, according to the crystal resonator 200 in the embodiment, in a case where the resonation area 111c, the first bonding member 41, and the second bonding member 42 satisfy a relationship expressed by 0<L1/L2≤0.97, in addition to the effect resulting from the crystal resonator 100 in the first embodiment, the following effects can be obtained.", "In the crystal resonator 200 of the embodiment, compared with the first embodiment, the stress which is generated due to the difference between the elongation amount or the shrinkage amount the resonator element 110 and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature, and is transferred to the resonation area 11c is further reduced.", "Accordingly, it is possible to further reduce the variation in characteristics of the crystal resonator 200, for example, the value of hysteresis compared with the first embodiment.", "Meanwhile, the hollow 111f may be formed in any position other than the position defined in the embodiment.", "For example, when viewed from above, the hollow 111f may be separately formed in two or more portions which are between the first bonding center 41b and the excitation electrodes 112a and 113a, and between the second bonding center 42b and the excitation electrodes 112a and 113a.", "Further, two or more hollows 111f may be formed between the first virtual line 51 and the excitation electrodes 112a and 113a in the direction which intersects with the first direction 54.Third Embodiment As an example of a resonation device according to the third embodiment, a crystal resonator 300 will be described.", "Note that, the same constituent element as in the crystal resonator 100 in the first embodiment is given the same reference numerals, repeated description will be omitted, and the description will focus on the differences from the crystal resonator 100 in the first embodiment.", "FIGS.", "6A and 6B are schematic configuration diagrams of a crystal resonator 300 as the resonation device according to the third embodiment, and FIG.", "6A is a plan view and FIG.", "6B is a sectional view taken along line C-C of FIG.", "6A.", "Resonator Element As illustrated in FIGS.", "6A and 6B, unlike the first embodiment, a resonator element 210 of the crystal resonator 300 includes a hole 211g, which penetrates from the upper surface 211a to the lower surface 211b on the crystal substrate 211, between the first virtual line 51 which connects the first bonding center 41b and the second bonding center 42b and excitation electrodes 212a and 213a, when viewed from above.", "In addition, the hole 211g extends to the second bonding center 42b from the first bonding center 41b in the direction along the first direction 54.In the crystal resonator 300 of the present embodiment, the stress which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element 210 and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature is transferred to a resonation area 211c of the resonator element 210, that is, the stress is transferred to the resonation area 211c which is an area which overlaps excitation electrodes 212a and 213a in the crystal substrate 211 of FIG.", "6A, and a hatched area in the crystal substrate 211 of FIG.", "6B via both an area which is not adjacent to the hole 211g and an area which is adjacent to the hole 211g of the crystal substrate 211.The area adjacent to the hole 211g of the crystal substrate 211 is more easily distorted than the area which is not adjacent to the hole 211g.", "As a result, the stress which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element 210 and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature of the crystal resonator 300 is less likely to be transferred to the resonation area 211c by distorting the area adjacent to the hole 211g.", "As described above, according to the crystal resonator 300 in the embodiment, in a case where the resonation area 211c, the first bonding member 41, and the second bonding member 42 satisfy a relationship expressed by 0<L1/L2≤0.97, in addition to the effect resulting from the crystal resonator 100 in the first embodiment, the following effects can be obtained.", "In the crystal resonator 300 of the embodiment, compared with the first embodiment, the stress which is generated due to the difference between the elongation amount or the shrinkage amount the resonator element 210 and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature of the crystal resonator 300, and is transferred to the resonation area 211c is further reduced.", "Accordingly, compared with the first embodiment, it is possible to further reduce the variation in characteristics of the crystal resonator 300, for example, the value of hysteresis compared with the first embodiment.", "Meanwhile, the hole 211g may be formed in any position other than the position defined in the embodiment.", "For example, when viewed from above, the hole 211g may be separately formed in two or more portions which are between the first bonding center 41b and the excitation electrodes 212a and 213a, and between the second bonding center 42b and the excitation electrodes 212a and 213a.", "Further, two or more holes 211g may be formed between the first virtual line 51 and the excitation electrodes 212a and 213a in the direction which intersects with the first direction 54.Fourth Embodiment As an example of the resonation device according to the fourth embodiment, a crystal resonator 400 will be described.", "Note that, the same constituent element as in the crystal resonator 100 in the first embodiment is given the same reference numerals, repeated description will be omitted, and the description will focus on the differences from the crystal resonator 100 in the first embodiment.", "FIGS.", "7A and 7C are schematic configuration diagrams of the crystal resonator 400 as a resonation device according to the fourth embodiment, and FIG.", "7A is a plan view, FIG.", "7B is a sectional view taken along line D-D of FIG.", "7A, and FIG.", "7C is a sectional view of a part of an excitation electrode portion of FIG.", "7B.", "Resonator Element The resonator element 310 of the crystal resonator 400 in the embodiment has a so-called mesa structure in which a first area 311h having a first thickness T3 and a second area 311k having a thickness T4 which is smaller than the thickness T3 are included within a distance in a direction which intersects with an upper surface and a lower surface of a crystal substrate 311, that is, the thickness of a crystal substrate 311.The crystal substrate 311 has a shape in which the first area 311h is surrounded by the second area 311k when viewed from above.", "As illustrated in FIG.", "7A, excitation electrodes 312a and 313a are formed into a rectangular shape when viewed from above, and are disposed so as to substantially overlap with each other.", "That is, when viewed from above, the center of the excitation electrode 312a and the center of the excitation electrode 313a are disposed so as to substantially overlap with each other.", "In addition, the crystal substrate 311 includes a resonation area 311c which is interposed between the excitation electrodes 312a and 313a, that is, an area which overlaps the excitation electrodes 312a and 313a in the crystal substrate 311 of FIG.", "7A, and a hatched area in the crystal substrate 311 of FIG.", "7B.", "Further, the excitation electrodes 312a and 313a are disposed so as to overlap the first area 311h in the first direction 54, and are disposed so as to overlap the first area 311h and the second area 311k in the direction which intersects with the first direction 54 when viewed from above.", "The resonation area 311c includes the resonation area center 311d.", "Since the excitation electrodes 312a and 313a are disposed as described above, the resonation area 311c is formed into a rectangular shape when viewed from above, and the resonation area center 311d and the center of each of excitation electrodes 312a and 313a substantially overlap with each other.", "The resonation area center 311d and the center of the first area 311h are disposed so as to substantially overlap with each other when viewed from above.", "In addition, in the embodiment, the first area 311h overlaps a large part of the resonation area 311c.", "The large part of the resonation area 311c is preferably equal to or greater than 80%, for example.", "Meanwhile, the center of each of the excitation electrodes 312a and 313a, the resonation area center 311d, and the center of the first area 311h are respectively the centroid (the center of a drawing) of a shape when the excitation electrodes 312a and 313a are viewed from above, the centroid (the center of a drawing) of a shape when the resonation area 311c is viewed from above, and the centroid (the center of a drawing) of a shape when the first area 311h is viewed from above.", "In addition, as illustrated in FIGS.", "7B and 7C, the excitation electrode 312a is disposed so as to cover the upper surface of the first area 311h, a side surface 311m which connects the upper surface of the first area 311h and the upper surface of the second area 311k, and the upper surface of the second area 311k in the direction which intersects with the first direction 54.The excitation electrode 313a is disposed so as to cover the lower surface of the first area 311h, a side surface 311n which connects the lower surface of the first area 311h and the lower surface of the second area 311k, and the lower surface of the second area 311k in the direction which intersects with the first direction 54.In the crystal resonator 400 in the embodiment, when viewed from above, the resonation area center 311d overlaps the first area 311h having a first thickness T3 and the first bonding center 41b and the second bonding center 42b overlap the second area 311k having the thickness T4 which is smaller than the thickness T3.That is, the resonator element 310 is supported by the bottom plate 21 via the first bonding member 41 and the second bonding member 42 in the second area 311k having the thickness T4 which is smaller than the thickness T3 of the first area 311h in which a large amount of resonation energy is concentrated while the resonator element 310 resonates.", "For this reason, the stress, which is generated due to the difference between the elongation amount or the shrinkage amount the resonator element 310, and the elongation amount or the shrinkage amount of the bottom plate 21 as the substrate in accordance with the change of the ambient temperature of crystal resonator 400 is transferred to the resonation area 311c via the second area 311k.", "In a case where the stress is transferred to the area in the thickness T3 via the area in the thickness T4, the stress is absorbed into the area in the thickness T4 which is largely distorted compared with the area in the thickness T3, and thus the stress transferred to the area in the thickness T3 is reduced.", "Accordingly, the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element 310, and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature of crystal resonator 400 is less likely to be transferred to the resonation area 311c by distorting the second area 311k of the resonator element 310.As described above, according to the crystal resonator 400 in the embodiment, in a case where the resonation area 311c, the first bonding member 41, and the second bonding member 42 satisfy a relationship expressed by 0<L1/L2≤0.97, in addition the effect resulting from the crystal resonator 100 in the first embodiment, the following effects can be obtained.", "In the crystal resonator 400 of the embodiment, compared with the first embodiment, the stress which is generated due to the difference between the elongation amount or the shrinkage amount the resonator element 310 and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature of the crystal resonator 400, and is transferred to the resonation area 311c is further reduced.", "Accordingly, compared with the first embodiment, it is possible to further reduce the variation in characteristics of the crystal resonator 400, for example, the value of hysteresis.", "Meanwhile, the resonator element 310 in the embodiment is disposed in such a manner that when viewed from above, the center of each of the excitation electrodes 312a and 313a, the resonation area center 311d, and the center of the first area 311h substantially overlap with each other; however, it is not limited thereto as long as the excitation electrodes 312a and 313a are disposed such that the resonation area center 311d and the first area 311h overlap with each other when viewed from above.", "In addition, the excitation electrodes 312a and 313a may be disposed such that when viewed from above, one excitation electrode is disposed in the inner side of the other excitation electrode, or both excitation electrodes 312a and 313a may be disposed so as to overlap only the first area 311h.", "Modification Example of Resonator Element In the resonation device of the embodiment, the resonator element is not necessarily to be a shape of the resonator element 310 as illustrated in FIGS.", "7A to 7C.", "Modification Example of the resonator element will be described with reference to FIGS.", "8A to 8E.", "Note that, the same constituent element as that of the resonator element 10 in the first embodiment or the resonator element 310 in the fourth embodiment is given the same reference numerals, repeated description will be omitted, and the description will focus on the differences from the resonator element 10 the first embodiment or the resonator element 310 in the fourth embodiment.", "FIGS.", "8A to 8E are schematic configuration diagrams illustrating Modification Example of the resonator element according to the embodiment, FIG.", "8A is a plan view of the resonator element 410 which is an example of Modification Example, FIG.", "8B is a sectional view taken along line E-E in FIG.", "8A, FIG.", "8C is a plan view of the resonator element 510 which is another example of Modification Example, FIG.", "8D is a sectional view taken along line F-F in FIG.", "8C, and FIG.", "8E is a partially enlarged sectional view of an excitation electrode portion in FIG.", "8D.", "Note that, in the following description, an upper side in FIGS.", "8B and 8D is referred to as “up” and a lower side is referred to as “down”.", "In addition, a surface on the upper side of each member in FIGS.", "8B and 8D is referred to as an upper surface, and a surface on the lower side is referred to as a lower surface.", "As illustrated in FIGS.", "8A and 8B, the resonator element 410 is configured such that the upper surface of the first area 411h of the crystal substrate 411 in the thickness T3 protrudes from the upper surface of the second area 411k in the thickness T4, and the lower surface of the first area 411h and the lower surface of the second area 411k are connected to each other in a planar shape.", "Excitation electrodes 412a and 413a are disposed so as to substantially overlap with each other when viewed from above.", "In addition, the crystal substrate 411 includes a resonation area 411c which is interposed between the excitation electrodes 412a and 413a, that is, an area which overlaps the excitation electrodes 412a and 413a in the crystal substrate 411 of FIG.", "8A, and a hatched area in the crystal substrate 411 of FIG.", "8B.", "Further, the resonation area center 411d is disposed so as to substantially overlap the center of the first area 411h.", "In addition, the excitation electrode 412a is disposed so as to cover the upper surface of the first area 411h, a side surface 411m which connects the upper surface of the first area 411h and the upper surface of the second area 411k, and the upper surface of the second area 411k in the direction which intersects with the first direction 54.As illustrated in FIGS.", "8C and 8D, the resonator element 510 includes an area in a thickness T5 in which the thickness of the first area 511h of the crystal substrate 511 is greater than the thickness T4 of the second area 511k, and an area in a thickness T6 which is greater than the thickness T5.In addition, the excitation electrodes 512a and 513a are disposed such that the area in the thickness T6 and the area in the thickness T5 of the first area 511h overlap the second area 511k when viewed from above.", "In addition, the crystal substrate 511 includes a resonation area 511c which is interposed between the excitation electrodes 512a and 513a, that is, an area which overlaps the excitation electrodes 512a and 513a in the crystal substrate 511 of FIG.", "8C, and a hatched area in the crystal substrate 511 of FIG.", "8D.", "Further, the resonation area center 511d is disposed so as to overlap the area in the thickness T6 of the first area 511h.", "In addition, as illustrated in FIGS.", "8D and 8E, the excitation electrode 512a is disposed so as to cover the upper surface of the area of the first area 511h in the thickness T6, a side surface 511m which connects the upper surface of the area of the first area 511h in the thickness T6 and the upper surface of the area of the first area 511h in the thickness T5, the upper surface of the area of the first area 511h in the thickness T5, a side surface 511n which connects the upper surface of the area of the first area 511h in the thickness T5 and the upper surface of the second area 511k, and the upper surface of the second area 511k in the direction which intersects with the first direction 54.The excitation electrode 513a is disposed so as to cover the lower surface of the area of the first area 511h in the thickness T6, a side surface 511p which connects the lower surface of the area of the first area 511h in the thickness T6 and the lower surface of the area of the first area 511h in the thickness T5, the lower surface of the area of the first area 511h in the thickness T5, a side surface 511q which connects the lower surface of the area of the first area 511h in the thickness T5 and the lower surface of the second area 511k, and the lower surface of the second area 511k in the direction which intersects with the first direction 54.The crystal resonator 400 which is formed of the resonator element 410 or the resonator element 510 can exhibit the same effect as the effect resulting from crystal resonator 400 which is formed of the resonator element 310 in the embodiment.", "Meanwhile, the resonator element 410 in Modification Example as described above is disposed in such a manner that when viewed from above, the center of each of the excitation electrodes 412a and 413a, the resonation area center 411d, and the center of the first area 411h substantially overlap with each other; however, it is not limited thereto as long as the excitation electrodes 412a and 413a are disposed such that the resonation area center 411d and the first area 411h overlap with each other when viewed from above.", "In addition, the excitation electrodes 412a and 413a may be disposed such that when viewed from above, one excitation electrode is disposed in the inner side of the other excitation electrode, or both excitation electrodes 412a and 413a may be disposed so as to overlap only the first area 411h.", "In addition, the resonator element 510 in Modification Example as described above is disposed in such a manner that when viewed from above, the center of each of the excitation electrodes 512a and 513a, the resonation area center 511d, and the center of the first area 511h substantially overlap with each other; however, it is not limited thereto as long as the excitation electrodes 512a and 513a are disposed such that the resonation area center 511d and the area of the first area 511h in the thickness T6 overlap with each other when viewed from above.", "In addition, the excitation electrodes 512a and 513a may be disposed such that when viewed from above, one excitation electrode is disposed in the inner side of the other excitation electrode, or both excitation electrodes 512a and 513a may be disposed so as to overlap only the first area 511h.", "Fifth Embodiment As an example of the resonation device according to the fifth embodiment, a crystal resonator 500 will be described.", "Note that, the same constituent element as that of the crystal resonator 100 in the first embodiment is given the same reference numerals, repeated description will be omitted, and the description will focus on the differences from the crystal resonator 100 in the first embodiment.", "FIGS.", "9A and 9B are schematic configuration diagrams of a crystal resonator 500 as a resonation device according to the fifth embodiment, and FIG.", "9A is a plan view and FIG.", "9B is a sectional view taken along line G-G of FIG.", "9A.", "Bonding Member As illustrated in FIGS.", "9A and 9B, unlike the crystal resonator 100 in the first embodiment, a first bonding member 141 and a second bonding member 142 of the crystal resonator 500 in the embodiment are formed of a metallic bump.", "The connection electrode 12c side of the first bonding member 141, that is, an upper surface 141a on the resonator element 10 side includes a first bonding center 141b.", "The connection electrode 13c side of the second bonding member 142, that is, an upper surface 142a of the resonator element 10 side includes a second bonding center 142b.", "The metallic bump is formed by a plating method, a bonding method, or the like.", "The plating method is performed by plating metal after forming a predetermined pattern such that the first bonding member 141 and the second bonding member 142 are formed in a predetermined position of the resonator element 10 or the package 20, and thereby the metallic bumps which are the first bonding member 141 and the second bonding member 142 can be formed.", "In addition, the bonding method is performed by connecting a metallic wire (thin wire) such as gold (Au) to a position in which each of the first bonding member 141 and the second bonding member 142 of the resonator element 10 or the package 20 is formed, and cutting the wire except for the connected part, and thereby the metallic bumps which are the first bonding member 141 and the second bonding member 142 can be formed.", "In addition, instead of the plating method and the bonding method, a method of forming the metallic bumps which are the first bonding member 141 and the second bonding member 142 by coating the position, in which the first bonding member 141 and the second bonding member 142 of the resonator element 10 or the package 20 are formed, with a paste (solvent) containing a metallic member by printing or dispensing, then heating the resonator element 10 or the package 20 which is coated with the paste so as to volatilize solvent components except for the metal, can be used.", "The shape of the metallic bump is not particularly limited, for example, it may be a columnar (cylindrical) shape, a polygonal prism, a truncated cone, and the like.", "In addition, the metallic wire may be formed of metal mainly containing silver (Ag), copper (Cu), aluminum (Al), platinum (Pt), and the like in addition to gold (Au).", "Further, a material of the metallic member may be metal mainly containing gold (Au), silver (Ag), copper (Cu), aluminum (Al), platinum (Pt), and the like, or an alloy such as a lead-free solder or a leaded solder.", "The metallic bump has less gas emission from the inside of the metallic bump due to the heat and the time elapse compared with a resin member such as an adhesive.", "For this reason, even when the crystal resonator 500 is heated, and time has elapsed after manufacturing the crystal resonator 500, the gas emission from the first bonding member 141 and the second bonding member 142 is reduced compared with a case where the first bonding member 141 and the second bonding member 142 are formed of a resin member.", "In addition, since the gas emitted from the first bonding member 141 and the second bonding member 142 is emitted to the inner space 26 in an air-tight state, the emitted gas is attached to the excitation electrodes 12a and 13a so as to increase a mass amount, and the emitted gas changes the excitation electrodes 12a and 13a, and thus the characteristics of the resonator element 10, for example, a resonance frequency, a frequency-temperature characteristic, and an equivalent series resistance are changed in some cases.", "From the above description, due to the heat and the time elapse, the gas emitted from the first bonding member 141 and the second bonding member 142 of the crystal resonator 500 in the embodiment is more reduced than the gas emitted from the first bonding member 41 and the second bonding member 42 of the crystal resonator 100 in the first embodiment.", "Accordingly, as compared with the crystal resonator 100 in the first embodiment, it is possible to reduce the variation of the characteristics of the crystal resonator 500, for example, the resonance frequency, the frequency-temperature characteristics, and the equivalent series resistance.", "As described above, according to the crystal resonator 500 in the embodiment, in a case where the resonation area 11c, the first bonding member 141, and the second bonding member 142 satisfy a relationship expressed by 0<L1/L2≤0.97, in addition the effect resulting from the crystal resonator 100 in the first embodiment, the following effects can be obtained.", "As compared with the crystal resonator 100 in the first embodiment, it is possible to reduce the gas emitted from the first bonding member 141 and the second bonding member 142 of the crystal resonator 500, and thus it is possible to reduce the variation of the characteristics of the crystal resonator 500, for example, the output frequency, the frequency-temperature characteristics, and the equivalent series resistance.", "Note that, the first bonding member 141 and the second bonding member 142 are formed of the metallic bump in the embodiment; however, even in a case where at least one bonding member of the first bonding member 141 and the second bonding member 142 may be formed of the metallic bump, and the other bonding member may be formed of a conductive or non-conductive adhesive, and the like, it is possible to result in the same effect as that in the embodiment from the above-described description.", "In addition, in a case where the first bonding member 141 and the second bonding member 142 are formed of the metallic bump, a diameter of each of the upper surface 141a of the first bonding member 141 and the upper surface 142a of the second bonding member 142 can be set to be equal to or less than 0.05 mm, and thus it is preferable that a lower limit of L1 is greater than 0.05 mm as a range in which the first bonding member 141 and the second bonding member 142 are not electrically connected to each other.", "in other words, it is preferable that L1/L2 satisfies a relationship expressed by 0.065<L1/L2≤0.97.Sixth Embodiment As an example of the resonation device according to the sixth embodiment, a crystal resonator 600 will be described.", "Note that, the same constituent element as that of the crystal resonator 100 in the first embodiment is given the same reference numerals, repeated description will be omitted, and the description will focus on the differences from the crystal resonator 100 in the first embodiment.", "FIGS.", "10A and 10B are schematic configuration diagrams of the crystal resonator 600 as a resonation device according to the sixth embodiment, and FIG.", "10A is a plan view and FIG.", "10B is a sectional view taken along line H-H of FIG.", "10A.", "As illustrated in FIGS.", "10A and 10B, the crystal resonator 600 in the embodiment satisfies the relationship expressed by 0<L1/L2≤0.97 in the crystal resonator 100 of the first embodiment, and is configured as follows.", "Here, in the crystal resonator 600, when a virtual line which passes through the resonation area center 11d and is parallel to the first direction 54 is set to be a third virtual line 57, a distance between the first bonding center 41b and the second virtual line 52 as a perpendicular line is set to be La, a distance between the second bonding center 42b and the second virtual line 52 is set to be Lb, a distance between the resonation area center 11d and an end portion 58 of the resonation area 11c, which is positioned on the first bonding member 41 side with respect to the second virtual line 52 and intersects with the third virtual line 57, is set to be Wa, and a distance between the resonation area center 11d and an end portion 59 of the resonation area 11c, which is positioned on the second bonding member 42 side with respect to the second virtual line 52 and intersects with the third virtual line 57, is set to be Wb.", "Hereinafter, a relationship between La, Lb, Wa, and Wb and the hysteresis in the crystal resonator 600 will be described.", "The inventors of the present application have obtained a result as indicated in FIG.", "11 by executing an experiment based on the assumption that in addition to the configuration of the first embodiment, the hysteresis of the crystal resonator 600 is related to La/Wa which is the ratio of the distance La between the first bonding center 41b and the second virtual line 52 to the distance Wa between the resonation area center 11d and an end portion 11c1 of the resonation area 11c, or related to Lb/Wb which is the ratio of the distance Lb between the second bonding center 42b and the second virtual line 52 to the distance Wb between the resonation area center 11d and an end portion 11c2 of the resonation area 11c.", "A resonator element 610 which is used in the aforementioned experiment is basically formed into substantially the same shape as that of the resonator element 10 in first embodiment, and the excitation electrodes 12a and 13a, and the resonation area 11c are disposed to be substantially line symmetry with respect to the second virtual line 52 when viewed from above.", "Accordingly, in the experiment, it can be said that the relationships Wa=Wb=0.45 mm, and La=Lb are satisfied.", "FIG.", "11 is a diagram illustrating a relationship between Lb/Wb (Lb/Wb=La/Wa in the experiment) and a hysteresis of the crystal resonator 600.In this regards, as described above, the hysteresis is the maximum value of the absolute value of the difference between the resonance frequency when the temperature is decreased and the resonance frequency when the temperature is increased in each temperature, which is acquired by measuring the resonance frequency of the crystal resonator 600 in each temperature when the temperature is decreased and the resonance frequency of the crystal resonator 600 in each temperature when the temperature is increased.", "In addition, in FIG.", "11, the hysteresis of the crystal resonator 600 is measured and acquired through the same method in the first embodiment.", "In the experiment, the hysteresises of the crystal resonator 600 having five types of ratios of Lb/Wb which are 0.40, 0.56, 0.77, 0.89, and 1.00 is measured and acquired.", "From FIG.", "11, it is found that when Lb/Wb which is the ratio of the distance Lb between the second bonding center 42b and the second virtual line 52 to the distance Wb between the resonation area center 11d and the end portion 59 of the resonation area 11c is 0.89, the hysteresis of the crystal resonator 600 is 0.07 ppm.", "In addition, from FIG.", "11, it is found that when a value smaller than 0.40 is input to the ratio of Lb/Wb, the hysteresis of the crystal resonator 600 becomes further smaller.", "Accordingly, in a range of 0<Lb/Wb≤0.89, the hysteresis of the crystal resonator 600 is 0.07 ppm or less.", "In addition, when Lb/Wb=0.77 is satisfied, the hysteresis of the crystal resonator 600 becomes 0.05 ppm.", "Accordingly, in a range of 0<Lb/Wb≤0.77, the hysteresis of the crystal resonator 600 is 0.05 ppm or less.", "As described in the first embodiment, in the case where the hysteresis of the crystal resonator 600 is used for, for example, a reference frequency source of a femtocell base station device of a mobile phone and the like, the hysteresis is preferably 0.07 ppm or less, and in a case where the hysteresis of the crystal resonator 600 is used for, for example, a device which is synchronized with a GPS signal and a macrocell base station device of a mobile phone which require the high frequency accuracy, the hysteresis is preferably 0.05 ppm or less.", "As described above, according to the crystal resonator 600 in the embodiment, it is possible to obtain the following effects in addition to the effect resulting from the crystal resonator 100 in the first embodiment.", "In the crystal resonator 600, for example, even in a case where the stress is generated due to a difference between the elongation amount or the shrinkage amount of the resonator element 610 and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature of the crystal resonator 600, Lb/Wb satisfies a relationship expressed by 0<Lb/Wb≤0.89, and thus it is possible to reduce the stress so as not to be transferred to the resonation area 11c of the resonator element 610.As a result, it is possible to reduce the variation in characteristics of the crystal resonator 600, for example, the value of hysteresis.", "In addition, in the crystal resonator 600, for example, even in a case where the stress is generated due to a difference between the elongation amount or the shrinkage amount of the resonator element 610 and the elongation amount or the shrinkage amount of the bottom plate 21 in accordance with the change of the ambient temperature of the crystal resonator 600, Lb/Wb satisfies a relationship expressed by 0<Lb/Wb≤0.77 and thus it is possible to further reduce the stress so as not to be transferred to the resonation area 11c of the resonator element 610.As a result, it is possible to reduce the variation in characteristics of the crystal resonator 600, for example, the value of hysteresis by 28% or more than the case where Lb/Wb satisfies a relationship expressed by 0<Lb/Wb≤0.89.Meanwhile, the experiment regarding Lb/Wb is performed when La=Lb and Wa=Wb are satisfied; however, La=Lb and Wa=Wb may not be necessarily satisfied.", "In this case, the experiment regarding Lb/Wb may be performed as long as the relationship expressed by 0<La/Wa≤0.89 or 0<La/Wa≤0.77 is satisfied in a case of La/Wb>Lb/Wb, and the relationship expressed by 0<Lb/Wb 0.89 or 0<Lb/Wb≤0.77 is satisfied in a case of La/Wa Lb/Wb.", "The reason for this is that the larger one of La/Wa and Lb/Wb easily transfers the stress with respect to the resonation area 11c, that is, the larger one of La/Wa and Lb/Wb easily transfers the stress to the wider range of the resonation area 11c.", "In addition, as in the first embodiment, even when the non-conductive member is used as at least one of the first bonding member 41 and the second bonding member 42, it is possible to obtain some effects of the first embodiment.", "That is, even when the non-conductive member is used as at least one of the first bonding member 41 and the second bonding member 42, the resonator element 610 is mechanically connected to the bottom plate 21 via the first bonding member 41 and the second bonding member 42.Accordingly, when the first bonding member 41 and the second bonding member 42 satisfy the relationships expressed by 0<La/Wa≤0.89 and 0<Lb/Wb≤0.89 in cases of La/Wa>Lb/Wb and La/Wa<Lb/Wb, it is possible to reduce the stress, which is generated due to the difference between the elongation amount or the shrinkage amount of the resonator element 610 and the elongation amount or the shrinkage amount of the bottom plate 21, so as not to be transferred to the resonation area 11c of the resonator element 610 in accordance with the change of the ambient temperature of the crystal resonator 600.As a result, it is possible to reduce the variation in characteristics of the crystal resonator 600, for example, the value of the hysteresis.", "Meanwhile, in the embodiment, a configuration such that when the relationship expressed by 0<L1/L2≤0.97 is satisfied in the crystal resonator 100 of the first embodiment, relationships expressed by 0<La/Wa≤0.89 and 0<Lb/Wb≤0.89 are satisfied in cases of La/Wa>Lb/Wb and La/Wa<Lb/Wb is described; however, it is possible to obtain the same effect even with a configuration such that only the relationships expressed by 0<La/Wa≤0.89 and 0<Lb/Wb≤0.89 are satisfied in the cases of La/Wa>Lb/Wb and La/Wa<Lb/Wb is described.", "Note that, the invention is not limited to the above-described embodiments, but can be performed by changing or modifying the above-described embodiments in various ways, or combining two or more of embodiments among the above-described embodiments.", "Seventh Embodiment Next, an oscillator of the seventh embodiment which includes any one of the crystal resonators 100, 200, 300, 400, 500, and 600 in the first embodiment to the sixth embodiment will be described with reference to FIGS.", "12A and 12B.", "In addition, an example of using the crystal resonator 100 of the first embodiment as the resonation device is described in the present embodiment.", "FIGS.", "12A and 12B are schematic configuration diagrams of an oscillator 1000 as one example of the oscillator which includes the crystal resonator 100 according to the embodiment of the invention, and FIG.", "12A is a plan view and FIG.", "12B is a sectional view taken along line J-J of FIG.", "12A.", "Note that, for the sake of convenience of description, a lid 1020 is not shown in FIG.", "12A.", "In addition, in the following description, an upper side in FIG.", "12B is referred to as “up” and a lower side is referred to as “down”, and a surface on the upper side of each member in FIG.", "12B is referred to as an upper surface, and a surface on the lower side is referred to as a lower surface.", "As illustrated in FIGS.", "12A and 12B, the oscillator 1000 is formed of the crystal resonator 100, a container 1010, the lid 1020, an oscillation circuit 1030, a bonding wire 1040, and the like.", "The container 1010 includes an inner space 1018 of which the center portion is depressed, and is provided with a seal ring 1012 which is formed into a frame shape along the upper surface of the container 1010, a plurality of internal connection terminals 1014 on a surface on the inner space 1018 side, and a plurality of external connection terminals 1016 on the lower surface.", "The internal connection terminal 1014 and the external connection terminal 1016 are electrically connected to each other via an internal wire (not shown).", "The crystal resonator 100 is mounted on the inner space 1018 side of the container 1010, and is electrically connected to the internal connection terminal 1014 via the internal wire (not shown).", "The oscillation circuit 1030 is a circuit for oscillating the crystal resonator 100, includes a plurality of pads 1032 on the upper surface thereof, and is on the upper surface (one surface) of the crystal resonator 100 via a bonding member (not shown), for example, an adhesive and a solder.", "The bonding wire 1040 is a metallic wire (thin wire) such as gold (Au), and is electrically connected to the pad 1032 and the internal connection terminal 1014.The lid 1020 is formed into a flat plate-like shape which covers an opening of the container 1010, and is bonded to the seal ring 1012 such that the inner space 1018 of the container 1010 is in an air-tight state.", "A voltage for causing at least one terminal in the plurality of external connection terminals 1016 to operate the oscillation circuit 1030 is applied to the above-described oscillator 1000, an oscillating signal which is output from the oscillation circuit 1030 is output from the at least one terminal in the plurality of external connection terminals 1016, that is, the other terminal of the external connection terminals 1016.As described above, when the oscillator 1000 as an example of the oscillator is provided with the crystal resonator 100 according to the embodiment of the invention, a stable frequency signal is output from the crystal resonator 100 as a reference frequency source of the oscillator, and thus it is possible to improve reliability of the operation of the oscillator 1000.Eighth Embodiment Next, an electronic apparatus of the eighth embodiment which includes any one of the crystal resonators 100, 200, 300, 400, 500, and 600 in the first embodiment to the sixth embodiment will be described with reference to FIG.", "13 to FIG.", "15.In addition, in the description of the embodiment, an example is described with reference the crystal resonator 100 in the first embodiment as the resonation device.", "FIG.", "13 is a perspective view illustrating a configuration of a mobile-type (or a Note book-type) personal computer 1100 as an example of an electronic apparatus which includes the crystal resonator 100 in the first embodiment.", "As illustrated in FIG.", "13, the personal computer 1100 is formed of a main body portion 1104 which includes a key board 1102, and a display unit 1108 which includes a display 1106, and the display unit 1108 is rotatably supported with respect to main body portion 1104 via a hinge structure.", "The crystal resonator 100 is built in such a personal computer 1100.As described above, when the mobile-type (or the note book-type) personal computer 1100 as an example of the electronic apparatus is provided with the crystal resonator 100 according to the embodiment of the invention, for example, as a clock source, a stable frequency signal is output from the crystal resonator 100 as a clock source which is supplied to the mobile-type personal computer 1100, and thus it is possible to improve reliability of the operation of the mobile-type personal computer 1100.FIG.", "14 is a perspective view schematically illustrating a configuration of a mobile phone 1200 (including PHS) as an example of the electronic apparatus which includes the crystal resonator 100 of the first embodiment.", "As illustrated in FIG.", "14, the mobile phone 1200 is provided with a plurality of operation buttons 1202, an earpiece 1204, and a mouthpiece 1206, and a display 1208 is disposed between the operation buttons 1202 and the earpiece 1204.The crystal resonator 100 is built in such a mobile phone 1200.As described above, when the mobile phone 1200 (including the PHS) as an example of the electronic apparatus is provided with the crystal resonator 100 according to the embodiment of the invention, for example, as a clock source, a stable frequency signal is output from the crystal resonator 100 as a clock source which is supplied to the mobile phone 1200, and thus it is possible to improve reliability of the operation of the mobile phone 1200.FIG.", "15 is a perspective view schematically illustrating a configuration of a digital camera 1300 as an example of the electronic apparatus which includes the crystal resonator 100 of the first embodiment.", "In addition, FIG.", "15 briefly illustrates connection between the digital camera 1300 and external devices.", "Here, in a film camera of the related art, a silver-halide photo film is sensitized to light by an optical image of an object, whereas in the digital camera 1300, an imaging signal (an image signal) is generated by photo-converting an optical image of an object via an imaging element such as a charge coupled device (CCD).", "A display 1304 is provided on a rear surface of a case 1302 (body) in the digital camera 1300, and performs a display based on the imaging signal by the CCD, and the display 1304 serves as a finder for displaying an object as an electronic image.", "In addition, a light receiving unit 1306 which includes an optical lens (an imaging optical system), a CCD, and the like is provided on the front surface (on the rear surface in the drawing) of the case 1302.When a photographer confirms an object displayed on the display 1304, and presses a shutter button 1308, an imaging signal of the CCD is transferred to and stored in a memory 1310 at the same time.", "In addition, in the digital camera 1300, an output terminal 1312 of a video signal and an input and output terminal 1314 for data communication are provided on the side surface of the case 1302.As illustrated in FIG.", "15, a TV monitor 1410 is connected to the output terminal 1312 of the video signal, and a personal computer 1420 is connected to the input and output terminal 1314 for data communication as necessary.", "Further, the imaging signal stored in the memory 1310 is output to the TV monitor 1410 or the personal computer 1420 by a predetermined control.", "The crystal resonator 100 is built in such a digital camera 1300.As described above, when the digital camera 1300 as an example of the electronic apparatus is provided with the crystal resonator 100 according to the embodiment of the invention, for example, as a clock source, a stable frequency signal is output from the crystal resonator 100 as a clock source which is supplied to the digital camera 1300, and thus it is possible to improve reliability of an operation of the digital camera 1300.Note that, the crystal resonator 100 of the first embodiment is applicable to other electronic apparatus in addition to the personal computer 1100 (a mobile-type personal computer) in FIG.", "13, the mobile phone 1200 in FIG.", "14, and the digital camera 1300 in FIG.", "15.Examples of other electronic apparatuses include an ink jet discharge device (for example, an ink jet printer), a laptop personal computer, a tablet-type personal computer, a storage area network device such as a router and a switch, local area network equipment, mobile terminal base station equipment, a television, a video camera, a video recorder, a car navigation system, a real-time clock device, a pager, an electronic organizer (including an electronic organizer with a communication function), an electronic dictionary, a calculator, electronic game equipment, a word processor, a workstation, a videophone, a security television monitor, an electronic binocular, a POS terminal, medical equipment (for example, an electronic thermometer, a blood pressure monitor, a blood glucose meter, an electrocardiogram measuring device, an ultrasonic diagnostic device, and an electronic endoscope), a fish finder, various measurement equipment, an instrument (for example, instruments of a vehicle, an aircraft, and a ship), a flight simulator, a head-mounted display, a motion trace, a motion tracking, a motion controller, and a pedestrian position orientation (PDR).", "Ninth Embodiment Next, a moving object of the ninth embodiment which includes any one of the crystal resonators 100, 200, 300, 400, 500, and 600 in the first embodiment to the sixth embodiment will be described with reference to FIG.", "16.In addition, an example of using the crystal resonator 100 of the first embodiment as the resonation device is described in the present embodiment.", "FIG.", "16 is a perspective view schematically illustrating an automobile 1500 as an example of the moving object which includes the crystal resonator 100 of the first embodiment.", "The crystal resonator 100 of the first embodiment is installed in the automobile 1500.As illustrated in FIG.", "16, in the automobile 1500 as the moving object, the electronic control unit 1510 which includes the crystal resonator 100 built therein and controls a tire 1504 and the like is installed in a car body 1502.In addition, the crystal resonator 100 according to the embodiment of the invention is widely applicable to an electronic control unit (ECU) for a keyless entry system, an immobilizer, a car navigation system, a car air conditioning system, an anti-lock brake system (ABS), an airbag, a tire pressure monitoring system (TPMS), an engine control system, a braking system, a battery monitor for a hybrid vehicles and an electric vehicle, and a body posture control system.", "As described above, when the automobile 1500 as an example of the moving object is provided with the crystal resonator 100 according to the embodiment of the invention, for example, as a clock, a stable frequency signal is output from the crystal resonator 100 as a clock source which is supplied to at least one of the automobile 1500 and the electronic control unit 1510, and thus it is possible to improve reliability of the operations of at least one of the automobile 1500 and the electronic control unit 1510." ] ]
Patent_15874384
[ [ "METHODS AND DEVICES FOR USER INTERACTIVE INTERFACES ON TOUCHSCREENS", "The present application is directed to devices and methods for touchscreen interactive interface.", "The method may comprise steps of combining two or more single-function buttons on the user interface of the touchscreen device into one multifunction button; monitoring a real-time touch operation with the multifunction button by a user; determining the type of the touch operation according to the time of the touch operation; and unfolding the two or more single-function buttons one after another around the multifunction button according to the type of the touch operation." ], [ "1.A method for operating an interactive user interface on a touchscreen device, the method comprising: combining, by a touchscreen device comprising a memory and a processor in communication with the memory, two or more single-function buttons on a user interface of the touchscreen device into one multifunction button at a docking location; monitoring, by the touchscreen device, a real-time touch operation of the interactive user interface by a user; determining, by the touchscreen device, a type of the real-time touch operation according to a length of time of the real-time touch operation; when the type of the real-time touch operation is determined to be a first type, unfolding, by the touchscreen device, the two or more single-function buttons in a user touch area around the docking location of the multifunction button; and when the type of the real-time touch operation is determined to be a second type: adjusting, by the touchscreen device, the docking location of the multifunction button according to a dragging movement operation performed by the user, and unfolding, by the touchscreen device, the two or more single-function buttons in the user touch area around the docking location of the multifunction button.", "2.The method according to claim 1, wherein the determining the type of the real-time touch operation according to the length of time of the real-time touch operation comprising: judging, by the touchscreen device, whether the length of time of the real-time touch operation satisfies a preset condition of the first type; when it is judged that the length of time of the real-time touch operation satisfies the preset condition of the first type, determining, by the touchscreen device, the type of the real-time touch operation to be the first type; and when it is judged that the length of time of the real-time touch operation does not satisfy the preset condition of the first type, determining, by the touchscreen device, the type of the real-time touch operation to be the second type.", "3.The method according to claim 2, wherein the judging whether the length of time of the real-time touch operation satisfies the preset condition of the first type comprises: judging, by the touchscreen device, whether the length of time of the real-time touch operation is shorter than a first predetermined threshold value.", "4.The method according to claim 1, wherein, when the type of the real-time touch operation is determined to be the second type, the adjusting the docking location of the multifunction button according to the dragging movement operation performed by the user comprises: determining, by the touchscreen device, whether the user performs the dragging movement operation on the multifunction button; and when it is determined that the user performs the dragging movement operation on the multifunction button: obtaining, by the touchscreen device, a moved location of the multifunction button when the user stops the dragging movement operation, and adjusting, by the touchscreen device, the docking location of the multifunction button according to the moved location of the multifunction button when the user stops the dragging movement operation.", "5.The method according to claim 1, wherein: the docking location of the multifunction button is movable within a movable area of the interactive user interface.", "6.the method according to claim 1, further comprising: dividing, by the touchscreen device, a movable area of the interactive user interface into a plurality of subareas, and determining, by the touchscreen device, a center of each of the plurality of subareas.", "7.The method according to claim 6, wherein: the plurality of subareas comprises three subareas.", "8.The method according to claim 1, wherein, when the type of the real-time touch operation is determined to be the second type, the adjusting the docking location of the multifunction button according to the dragging movement operation performed by the user further comprises: obtaining, by the touchscreen device, a moved location of the multifunction button; determining, by the touchscreen device, an adjusted docking location of the multifunction button as a center of a particular subarea where the moved location is located; and adjusting, by the touchscreen device, the docking location of the multifunction button according to the adjusted docking location of the multifunction button.", "9.The method according to claim 8, wherein the obtaining the moved location of the multifunction button further comprises: determining, by the touchscreen device, whether a current location of the multifunction button is outside of a movable area of the interactive user interface in a vertical direction; adjusting, by the touchscreen device, a vertical coordinate of the current location of the multifunction button to a second predetermined threshold value; and maintaining, by the touchscreen device, a horizontal coordinate of the current location of the multifunction button.", "10.The method according to claim 1, wherein, when the type of the real-time touch operation is determined to be a second type, the unfolding the two or more single-function buttons in the user touch area around the docking location of the multifunction button comprises: unfolding, by the touchscreen device, the two or more single-function buttons into an arc around the multifunction button, wherein: the arc has a predetermined radius, and an angle measure of the arc is dependent on the docking location of the multifunction button.", "11.The method according to claim 10, wherein distance between any two neighboring single-function buttons of the two or more single-function buttons is equal, and distance between any of the two or more single-function buttons and the multifunction button is equal.", "12.The method according to claim 1, wherein the multifunction button is a semitransparent button.", "13.A touchscreen device with an interactive user interface, comprising: a memory storing instructions for conducting operations on the touchscreen device; a processor in communication with the memory, when the processor executes the instructions, the process is configured to cause the touchscreen device to: combine two or more single-function buttons on a user interface of the touchscreen device into one multifunction button at a docking location; monitor a real-time touch operation of the interactive user interface by a user; determine a type of the real-time touch operation according to a length of time of the real-time touch operation; when the type of the real-time touch operation is determined to be a first type, unfolding, by the touchscreen device, the two or more single-function buttons in a user touch area around the docking location of the multifunction button; and when the type of the real-time touch operation is determined to be a second type: adjusting, by the touchscreen device, the docking location of the multifunction button according to a dragging movement operation performed by the user, and unfolding, by the touchscreen device, the two or more single-function buttons in the user touch area around the docking location of the multifunction button.", "14.The touchscreen device according to claim 13, wherein, when the processor is configured to cause the touchscreen device to determine the type of the real-time touch operation according to the length of time of the real-time touch operation, the processor is configured to cause the touchscreen device to: judge whether the length of time of the real-time touch operation satisfies a preset condition of the first type; when it is judged that the length of time of the real-time touch operation satisfies the preset condition of the first type, determine the type of the real-time touch operation to be the first type; and when it is judged that the length of time of the real-time touch operation does not satisfy the preset condition of the first type, determine the type of the real-time touch operation to be the second type.", "15.The touchscreen device according to claim 14, wherein, when the processor is configured to cause the touchscreen device to judge whether the length of time of the real-time touch operation satisfies the preset condition of the first type, the processor is configured to cause the touchscreen device to: judge whether the length of time of the real-time touch operation is shorter than a first predetermined threshold value.", "16.The touchscreen device according to claim 13, wherein, when, when the type of the real-time touch operation is determined to be the second type, the processor is configured to cause the touchscreen device to adjust the docking location of the multifunction button according to the dragging movement operation performed by the user, the processor is configured to cause the touchscreen device to: determine whether the user performs the dragging movement operation on the multifunction button; and when it is determined that the user performs the dragging movement operation on the multifunction button: obtain a moved location of the multifunction button when the user stops the dragging movement operation, and adjust the docking location of the multifunction button according to the moved location of the multifunction button when the user stops the dragging movement operation.", "17.The touchscreen device according to claim 13, wherein, when the processor executes the instructions, the processor is further configured to cause the touchscreen device to: divide a movable area of the interactive user interface into a plurality of subareas, and determine a center of each of the plurality of subareas.", "18.The touchscreen device according to claim 17, wherein: the plurality of subareas comprises three subareas.", "19.The touchscreen device according to claim 13, wherein, when, when the type of the real-time touch operation is determined to be the second type, the processor is configured to cause the touchscreen device to adjust the docking location of the multifunction button according to the dragging movement operation performed by the user, the processor is further configured to cause the touchscreen device to: obtain a moved location of the multifunction button; determine an adjusted docking location of the multifunction button as a center of a particular subarea where the moved location is located; and adjust the docking location of the multifunction button according to the adjusted docking location of the multifunction button.", "20.The touchscreen device according to claim 19, wherein, when the processor is configured to cause the touchscreen device to obtain the moved location of the multifunction button, the processor is further configured to cause the touchscreen device to: determine whether a current location of the multifunction button is outside of a movable area of the interactive user interface in a vertical direction; adjust a vertical coordinate of the current location of the multifunction button to a second predetermined threshold value; and maintain a horizontal coordinate of the current location of the multifunction button.", "21.The touchscreen device according to claim 13, wherein, when, when the type of the real-time touch operation is determined to be a second type, the processor is configured to cause the touchscreen device to unfold the two or more single-function buttons in the user touch area around the docking location of the multifunction button, the processor is further configured to cause the touchscreen device to: unfold the two or more single-function buttons into an arc around the multifunction button, wherein: the arc has a predetermined radius, and an angle measure of the arc is dependent on the docking location of the multifunction button.", "22.The touchscreen device according to claim 21, wherein distance between any two neighboring single-function buttons of the two or more single-function buttons is equal, and distance between any of the two or more single-function buttons and the multifunction button is equal.", "23.The touchscreen device according to claim 13, wherein the multifunction button is a semitransparent button." ], [ "<SOH> BACKGROUND <EOH>With the development of the wireless communication technology and touchscreen technology, more and more electronic equipment adopt the touchscreen technology, such as touchscreen cellphones and tablet PCs and so on, and become hand-held terminals frequently used by users.", "On the user interface of the current touchscreen devices, the user operation point is usually fixed on a certain location.", "As shown in FIG.", "1 , taking a touchscreen cellphone for example, it is generally divided into the top touch area and buttons 101 , the cellphone supporting component 102 , the touchable screen 103 and the bottom touch area and buttons 104 .", "As shown in FIG.", "1 , the user touchable area of the current touchscreen cellphone is mainly characterized in that there are several fixed buttons on the top and bottom of the cellphone screen for the user's touch operation and the touch area is generally rectangular.", "Applicant has found in the research that: as most users use one thumb to operate the touchscreen devices, as shown in FIG.", "2 , if the screen of the touchscreen device is too large, it will be inconvenient for the user to operate, which will increase unnecessary user action times on the touchscreen device and thus degrade the performance of the touchscreen device." ], [ "<SOH> SUMMARY <EOH>A preferred embodiment of the present application provides a user interface interactive method which combines two or more single-function buttons on the user interface of the touchscreen device into one multifunction button.", "The method may include steps of: monitoring the real-time touch operation with the multifunction button by a user; determining the type of the touch operation according to the time of the touch operation; and unfolding the two or more single-function buttons one after another around the multifunction button according to the type of the touch operation.", "In a preferred embodiment, the type of the touch operation may include Type I touch operation and Type II touch operation, which may be determined according to the time of the touch operation.", "Determining the type of the touch operation may include steps of: judging whether the time of the touch operation satisfies the preset conditions of Type I touch operation.", "If it does, the type of the touch operation may be determined as Type I touch operation; if not, the type of the touch operation may be determined as Type II touch operation.", "In a preferred embodiment, Type I touch operation may be a short press and Type II touch operation may be a long press.", "Determining whether the time of a touch operation satisfies the preset conditions of Type I touch operation may include determining whether the time of the touch operation is greater than a preset first threshold value.", "In a preferred embodiment, to unfold the two or more single-function buttons one after another around the multifunction button according to the type of a touch operation may include steps of: unfolding the two or more single-function buttons one after another in a user touch area around the multifunction button when the touch operation is Type I touch operation; and when the touch operation is Type II touch operation, adjusting the docking location of the multifunction button according to the movement operation of the multifunction button by the user, and unfolding the two or more single-function buttons one after another in the user touch area around the docking location of the multifunction button after the multifunction button moves and/or has been moved.", "In a preferred embodiment, unfolding the two or more single-function buttons one after another in the user touch area around the multifunction button may include: unfolding the two or more single-function buttons evenly into an arc according to a preset radius around the multifunction button, wherein the distances of any two neighboring single-function buttons of the two or more single-function buttons are equal and the distances from any of the two or more single-function buttons to the multifunction button are equal.", "In a preferred embodiment, adjusting the docking location of the multifunction button according to the movement operation of the multifunction button by the user may include: monitoring whether the user has moved the multifunction button; if the user has moved the multifunction button, obtaining the moved location of the multifunction button after the user stops the movement operation; and when the user stops the touch operation, determining the docking location of the multifunction button according to the area of the user interface to where the multifunction button has been moved.", "A preferred embodiment of the present application may also include: dividing the movable area of the multifunction button on the user interface into three equal subareas, wherein the movable area is located on the bottom of the touchscreen device and its height is the horizontal area of a preset second threshold value; determining center coordinates of the three subareas; Obtaining the moved location of the multifunction button after it is moved may include: detecting whether the current multifunction button is out of the movable area in a vertical direction during its movement.", "If it is, correcting the vertical coordinate of the location of the multifunction button after it is moved to the second threshold value of the movable area.", "The horizontal coordinate of the moved location may remain the same.", "Determining the docking location of the multifunction button according to the area of the moved location on the user interface may include: determining the docking location of the multifunction button as the center coordinate of the current subarea where the moved location is located.", "In a preferred embodiment, unfolding the two or more single-function buttons one after another in the user touch area around the docking location of the multifunction button after the multifunction button is moved may include: in the user touch area around the docking location of the multifunction button, unfolding evenly the two or more single-function buttons into an arc according to a preset radius around the multifunction button, wherein the distances of any two neighboring single-function buttons of the two or more single-function buttons are equal and the distances from any of the two or more single-function buttons to the multifunction button are equal.", "In a preferred embodiment, the multifunction button is a semitransparent button.", "According to an preferred embodiment of the present application, a user interface interactive method for touchscreen devices which combines two or more single-function buttons on the user interface of the touchscreen device may include: monitoring a real-time screen-touch operation with the multifunction button by a user; determining a type of the touch operation according to the time of the touch operation; and judging whether the type of the touch operation satisfies preset conditions to move the multifunction button.", "If the touch operation satisfies the preset conditions, determine the docking location of the multifunction button according to the movement operation of the multifunction button by the user; if not, unfold the two or more single-function buttons one after another around the multifunction button.", "A user interface interactive device for touchscreen devices may include a combination module, which may be used to combine two or more single-function buttons on the user interface of the touchscreen device into one multifunction button; a monitoring module, which may be used to monitor the real-time touch operation with the multifunction button by the user; a first determination module, which may be used to determine the type of the touch operation according to the time of the touch operation; and an interaction module, which may be used to unfold the two or more single-function buttons one after another around the multifunction button according to the type of the touch operation.", "In a preferred embodiment, the type of the touch operation includes Type I touch operation and Type II touch operation, and the first determination module comprises particularly: a first judgment submodule, which may be used to judge whether the time of the touch operation satisfies the preset conditions of Type I touch operation; a first determination submodule, which may be used to determine the type of the touch operation as the Type I touch operation when the result of the judgment submodule is yes; and a second determination submodule, which may be used to determine the type of the touch operation as the Type II touch operation when the result of the judgment submodule is no.", "In a preferred embodiment, the Type I touch operation may be a short press and the Type II touch operation may be a long press.", "The Type I judgment submodule may be configured to judge whether the time of the touch operation is greater than the preset first threshold value.", "In a preferred embodiment, the interaction module may include a first interaction submodule, an adjustment submodule, and a second interaction submodule, wherein, when the touch operation is Type I touch operation, the first interaction submodule may be used to unfold the two or more single-function buttons one after another in the user touch area around the multifunction button; when the touch operation is Type II touch operation, the adjustment submodule may be used to adjust the docking location of the multifunction button according to the movement operation of the multifunction button by the user; and the second interaction submodule may be used to unfold the two or more single-function buttons one after another in the user touch area around the docking location of the multifunction button after it is moved.", "In a preferred embodiment, the first interaction submodule may be configured to unfold evenly the two or more single-function buttons into an arc around the multifunction button according to the preset radius, wherein the distances of any two neighboring single-function buttons of the two or more single-function buttons are equal and the distances from any of the two or more single-function buttons to the multifunction button are equal.", "In a preferred embodiment, the adjustment submodule may include a monitoring submodule and obtaining submodule.", "The adjustment submodule may be used to monitor whether the user has moved the multifunction button.", "When the result of the monitoring submodule is yes, the obtaining submodule may obtain a moved location of the multifunction button after it is moved when the user stops the movement operation.", "The interaction module may also include a third determination submodule, which may be used to determine the docking location of the multifunction button according to the area of the move location on the user interface when the user stops the movement operation.", "In a preferred embodiment, adjustment submodule may also include a trisection module, which may be used to divide the movable area of the multifunction button on the user interface into three equal subareas, wherein the movable area may be located on the bottom of the touchscreen device and its height may be the horizontal area of the preset second threshold value.", "The adjustment submodule may also include a second determination module, which may be used to determine the center coordinate points of the three subareas.", "Accordingly, the obtaining the submodule may include a detection submodule, which may be used to detect whether the current multifunction button is out of the movable area in the vertical direction during its movement; and a correction submodule, which may be used to correct the vertical coordinate of the move location of the multifunction button after it is moved, to the second threshold value of the movable area, while the horizontal coordinate of the move location is the same as that of the location after it is moved.", "Accordingly, the third determination submodule may be configured to determine the docking location of the multifunction button as the center coordinate point of the current subarea according to the current subarea where the move location is located.", "In a preferred embodiment, the second interaction submodule may be configured to unfold evenly the two or more single-function buttons into an arc according to the preset radius in the user touch area around the docking location of the multifunction button, wherein the distances of any two neighboring single-function buttons of the two or more single-function buttons may be equal and the distances from any of the two or more single-function buttons to the multifunction button may be equal.", "According to a preferred embodiment of the present application, a user interface interactive device for a touchscreen device may include a combination module, which may be used to combine two or more single-function buttons on the user interface of the touchscreen device into one multifunction button; a monitoring module, which may be used to monitor the real-time touch operation with the multifunction button by the user; a first determination module, which may be used to determine the type of the touch operation according to the time of the touch operation; a judgment module, which may be used to judge whether the type of the touch operation satisfies the preset conditions to move the multifunction button; a second determination module, which may be used to determine the docking location of the multifunction button according to the movement operation of the multifunction button by the user when the result of the judgment module is yes; and an unfolding module, which may be used to unfold the two or more single-function buttons one after another around the multifunction button when the result of the judgment module is no.", "According to a preferred embodiment of the present application, a touchscreen device, which may include any of the devices as described above.", "By combining several single-function buttons into one multifunction button, users may not need to consider the location of every single-function button in the current technology during the operation, instead, they may only need to operate with the multifunction button.", "In addition, as the combined single-function buttons are around the multifunction button, users may also control the screen of the single-function buttons they need to operate with by moving the multifunction button, which makes it convenient for users to use the single-function buttons on the touchscreen.", "Furthermore, with convenient operation, it will not increase the operation times on the touchscreen and thus will reduce the wear of the touchscreen of the touchscreen devices from users' operation." ], [ "PRIORITY STATEMENT This application is a continuation under 35 U.S.C.", "§ 120 of U.S. application Ser.", "No.", "13/909,570 filed on Jun.", "4, 2013, pending, which is based upon and claims the benefit of Chinese Patent Application No.", "201210184210.1 filed on Jun.", "5, 2012, all of which are incorporated herein by reference in their entireties.", "FIELD OF THE INVENTION The present invention relates generally to touchscreen technology, particularly, the present invention relates to methods and devices for user interactive interfaces on touchscreens.", "BACKGROUND With the development of the wireless communication technology and touchscreen technology, more and more electronic equipment adopt the touchscreen technology, such as touchscreen cellphones and tablet PCs and so on, and become hand-held terminals frequently used by users.", "On the user interface of the current touchscreen devices, the user operation point is usually fixed on a certain location.", "As shown in FIG.", "1, taking a touchscreen cellphone for example, it is generally divided into the top touch area and buttons 101, the cellphone supporting component 102, the touchable screen 103 and the bottom touch area and buttons 104.As shown in FIG.", "1, the user touchable area of the current touchscreen cellphone is mainly characterized in that there are several fixed buttons on the top and bottom of the cellphone screen for the user's touch operation and the touch area is generally rectangular.", "Applicant has found in the research that: as most users use one thumb to operate the touchscreen devices, as shown in FIG.", "2, if the screen of the touchscreen device is too large, it will be inconvenient for the user to operate, which will increase unnecessary user action times on the touchscreen device and thus degrade the performance of the touchscreen device.", "SUMMARY A preferred embodiment of the present application provides a user interface interactive method which combines two or more single-function buttons on the user interface of the touchscreen device into one multifunction button.", "The method may include steps of: monitoring the real-time touch operation with the multifunction button by a user; determining the type of the touch operation according to the time of the touch operation; and unfolding the two or more single-function buttons one after another around the multifunction button according to the type of the touch operation.", "In a preferred embodiment, the type of the touch operation may include Type I touch operation and Type II touch operation, which may be determined according to the time of the touch operation.", "Determining the type of the touch operation may include steps of: judging whether the time of the touch operation satisfies the preset conditions of Type I touch operation.", "If it does, the type of the touch operation may be determined as Type I touch operation; if not, the type of the touch operation may be determined as Type II touch operation.", "In a preferred embodiment, Type I touch operation may be a short press and Type II touch operation may be a long press.", "Determining whether the time of a touch operation satisfies the preset conditions of Type I touch operation may include determining whether the time of the touch operation is greater than a preset first threshold value.", "In a preferred embodiment, to unfold the two or more single-function buttons one after another around the multifunction button according to the type of a touch operation may include steps of: unfolding the two or more single-function buttons one after another in a user touch area around the multifunction button when the touch operation is Type I touch operation; and when the touch operation is Type II touch operation, adjusting the docking location of the multifunction button according to the movement operation of the multifunction button by the user, and unfolding the two or more single-function buttons one after another in the user touch area around the docking location of the multifunction button after the multifunction button moves and/or has been moved.", "In a preferred embodiment, unfolding the two or more single-function buttons one after another in the user touch area around the multifunction button may include: unfolding the two or more single-function buttons evenly into an arc according to a preset radius around the multifunction button, wherein the distances of any two neighboring single-function buttons of the two or more single-function buttons are equal and the distances from any of the two or more single-function buttons to the multifunction button are equal.", "In a preferred embodiment, adjusting the docking location of the multifunction button according to the movement operation of the multifunction button by the user may include: monitoring whether the user has moved the multifunction button; if the user has moved the multifunction button, obtaining the moved location of the multifunction button after the user stops the movement operation; and when the user stops the touch operation, determining the docking location of the multifunction button according to the area of the user interface to where the multifunction button has been moved.", "A preferred embodiment of the present application may also include: dividing the movable area of the multifunction button on the user interface into three equal subareas, wherein the movable area is located on the bottom of the touchscreen device and its height is the horizontal area of a preset second threshold value; determining center coordinates of the three subareas; Obtaining the moved location of the multifunction button after it is moved may include: detecting whether the current multifunction button is out of the movable area in a vertical direction during its movement.", "If it is, correcting the vertical coordinate of the location of the multifunction button after it is moved to the second threshold value of the movable area.", "The horizontal coordinate of the moved location may remain the same.", "Determining the docking location of the multifunction button according to the area of the moved location on the user interface may include: determining the docking location of the multifunction button as the center coordinate of the current subarea where the moved location is located.", "In a preferred embodiment, unfolding the two or more single-function buttons one after another in the user touch area around the docking location of the multifunction button after the multifunction button is moved may include: in the user touch area around the docking location of the multifunction button, unfolding evenly the two or more single-function buttons into an arc according to a preset radius around the multifunction button, wherein the distances of any two neighboring single-function buttons of the two or more single-function buttons are equal and the distances from any of the two or more single-function buttons to the multifunction button are equal.", "In a preferred embodiment, the multifunction button is a semitransparent button.", "According to an preferred embodiment of the present application, a user interface interactive method for touchscreen devices which combines two or more single-function buttons on the user interface of the touchscreen device may include: monitoring a real-time screen-touch operation with the multifunction button by a user; determining a type of the touch operation according to the time of the touch operation; and judging whether the type of the touch operation satisfies preset conditions to move the multifunction button.", "If the touch operation satisfies the preset conditions, determine the docking location of the multifunction button according to the movement operation of the multifunction button by the user; if not, unfold the two or more single-function buttons one after another around the multifunction button.", "A user interface interactive device for touchscreen devices may include a combination module, which may be used to combine two or more single-function buttons on the user interface of the touchscreen device into one multifunction button; a monitoring module, which may be used to monitor the real-time touch operation with the multifunction button by the user; a first determination module, which may be used to determine the type of the touch operation according to the time of the touch operation; and an interaction module, which may be used to unfold the two or more single-function buttons one after another around the multifunction button according to the type of the touch operation.", "In a preferred embodiment, the type of the touch operation includes Type I touch operation and Type II touch operation, and the first determination module comprises particularly: a first judgment submodule, which may be used to judge whether the time of the touch operation satisfies the preset conditions of Type I touch operation; a first determination submodule, which may be used to determine the type of the touch operation as the Type I touch operation when the result of the judgment submodule is yes; and a second determination submodule, which may be used to determine the type of the touch operation as the Type II touch operation when the result of the judgment submodule is no.", "In a preferred embodiment, the Type I touch operation may be a short press and the Type II touch operation may be a long press.", "The Type I judgment submodule may be configured to judge whether the time of the touch operation is greater than the preset first threshold value.", "In a preferred embodiment, the interaction module may include a first interaction submodule, an adjustment submodule, and a second interaction submodule, wherein, when the touch operation is Type I touch operation, the first interaction submodule may be used to unfold the two or more single-function buttons one after another in the user touch area around the multifunction button; when the touch operation is Type II touch operation, the adjustment submodule may be used to adjust the docking location of the multifunction button according to the movement operation of the multifunction button by the user; and the second interaction submodule may be used to unfold the two or more single-function buttons one after another in the user touch area around the docking location of the multifunction button after it is moved.", "In a preferred embodiment, the first interaction submodule may be configured to unfold evenly the two or more single-function buttons into an arc around the multifunction button according to the preset radius, wherein the distances of any two neighboring single-function buttons of the two or more single-function buttons are equal and the distances from any of the two or more single-function buttons to the multifunction button are equal.", "In a preferred embodiment, the adjustment submodule may include a monitoring submodule and obtaining submodule.", "The adjustment submodule may be used to monitor whether the user has moved the multifunction button.", "When the result of the monitoring submodule is yes, the obtaining submodule may obtain a moved location of the multifunction button after it is moved when the user stops the movement operation.", "The interaction module may also include a third determination submodule, which may be used to determine the docking location of the multifunction button according to the area of the move location on the user interface when the user stops the movement operation.", "In a preferred embodiment, adjustment submodule may also include a trisection module, which may be used to divide the movable area of the multifunction button on the user interface into three equal subareas, wherein the movable area may be located on the bottom of the touchscreen device and its height may be the horizontal area of the preset second threshold value.", "The adjustment submodule may also include a second determination module, which may be used to determine the center coordinate points of the three subareas.", "Accordingly, the obtaining the submodule may include a detection submodule, which may be used to detect whether the current multifunction button is out of the movable area in the vertical direction during its movement; and a correction submodule, which may be used to correct the vertical coordinate of the move location of the multifunction button after it is moved, to the second threshold value of the movable area, while the horizontal coordinate of the move location is the same as that of the location after it is moved.", "Accordingly, the third determination submodule may be configured to determine the docking location of the multifunction button as the center coordinate point of the current subarea according to the current subarea where the move location is located.", "In a preferred embodiment, the second interaction submodule may be configured to unfold evenly the two or more single-function buttons into an arc according to the preset radius in the user touch area around the docking location of the multifunction button, wherein the distances of any two neighboring single-function buttons of the two or more single-function buttons may be equal and the distances from any of the two or more single-function buttons to the multifunction button may be equal.", "According to a preferred embodiment of the present application, a user interface interactive device for a touchscreen device may include a combination module, which may be used to combine two or more single-function buttons on the user interface of the touchscreen device into one multifunction button; a monitoring module, which may be used to monitor the real-time touch operation with the multifunction button by the user; a first determination module, which may be used to determine the type of the touch operation according to the time of the touch operation; a judgment module, which may be used to judge whether the type of the touch operation satisfies the preset conditions to move the multifunction button; a second determination module, which may be used to determine the docking location of the multifunction button according to the movement operation of the multifunction button by the user when the result of the judgment module is yes; and an unfolding module, which may be used to unfold the two or more single-function buttons one after another around the multifunction button when the result of the judgment module is no.", "According to a preferred embodiment of the present application, a touchscreen device, which may include any of the devices as described above.", "By combining several single-function buttons into one multifunction button, users may not need to consider the location of every single-function button in the current technology during the operation, instead, they may only need to operate with the multifunction button.", "In addition, as the combined single-function buttons are around the multifunction button, users may also control the screen of the single-function buttons they need to operate with by moving the multifunction button, which makes it convenient for users to use the single-function buttons on the touchscreen.", "Furthermore, with convenient operation, it will not increase the operation times on the touchscreen and thus will reduce the wear of the touchscreen of the touchscreen devices from users' operation.", "BRIEF DESCRIPTION OF THE DRAWINGS The embodiments described below may be more fully understood by reading the following description in conjunction with the drawings, in which: FIG.", "1 is a schematic diagram of the user interface of a touchscreen device; FIG.", "2 is a schematic diagram of a user operation area of the touchscreen device; FIG.", "3 is a flow diagram of an embodiment 1 of a first method of a preferred embodiment of the present invention; FIG.", "4 is a schematic diagram of a location of the multifunction button in embodiment 1 of the first method of the present invention; FIG.", "5 is a flow diagram of step 302 in embodiment 1 of the first method of the present invention; FIG.", "6 is an instance flow diagram of step 302 in embodiment 1 of the first method of the present invention; FIG.", "7 is a schematic diagram of the interface when an embodiment of the present invention unfolds several single-function buttons on the user interface; FIG.", "8 is a flow diagram of an embodiment 2 of the first method of the present invention; FIGS.", "9 and 10 are schematic diagrams of unfolding single-function buttons when a docking location of the multifunction button is on the left and right side of the user interface; FIG.", "11 is a flow diagram of an embodiment 3 of the first method of the present invention; FIG.", "12 is a schematic diagram of an embodiment of the second method of the present invention; FIG.", "13 is a structural schematic diagram of embodiment 1 of the first device of the present invention; FIG.", "14 is a structural schematic diagram of a first determination module 1103 in embodiment 1 of the first device of the present invention; FIG.", "15 is a structural schematic diagram of interaction module 1304 in embodiment 1 of the first device of the present invention; FIG.", "16 is a structural schematic diagram of an embodiment 2 of the first device of the present invention; FIG.", "17 is a structural schematic diagram of an embodiment 3 of the first device of the present invention; and FIG.", "18 is a structural schematic diagram of an embodiment of the second device of the present invention.", "DETAILED DESCRIPTION Preferred embodiments will now be described more fully with reference to the accompanying drawings, in which preferred embodiments are shown.", "Preferred embodiments may, however, be embodied in many different forms and should not be construed as being limited to the preferred embodiments set forth herein; rather, preferred embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the concept of the invention to one skilled in the art.", "In the drawings, the regions are exaggerated for clarity and not necessarily in scale.", "Like reference numerals in the drawings denote like elements, and thus, their description will not be repeated.", "The present application is directed to user interface interactive methods and devices for touchscreen devices.", "Each of the touchscreen devices may include a non-transitory computer-readable and/or processor-readable storage medium and a processor in communication with the non-transitory computer-readable and/or processor-readable storage medium.", "The non-transitory computer-readable and/or processor-readable storage medium may store sets of instructions for conducting operations on a touchscreen.", "The processor may be configured to execute the sets of instructions, which conduct the user interface interactive methods.", "Here, the computer may be any type of electrical computational device, such as a laptop, a desktop, a tablet, a mobile phone (e.g., a featured cell phone and a smartphone), and/or a personal digital assistance (PDA), etc.", "the computer may also be the electrical computation part of any other device, such as the electrical computation part of a camera, a GPS device, and/or a motor vehicle, etc.", "In an even broader sense, the term computer used here may be any electrical designs that is capable of operating programs and processing data by a processor.", "According to the methods, the processor may combine two or more single-function buttons on the user interface of the touchscreen device into one multifunction button and unfold the two or more single-function buttons around the multifunction button when a user touches the multifunction button.", "Because there may be only one multifunction button and its location may be fixed and all buttons may be unfolded around the multifunction button on the bottom of the touchscreen device, it is convenient for the user to operate the touchscreen device.", "In the embodiments of the present application, for convenience of description, a touchscreen cellphone is adopted to illustrate the present application.", "However, the embodiments of the present invention may also be applied to other touchscreen devices like tablet PCs.", "FIG.", "3 shows a flow diagram of embodiment 1 of the first user interface interactive method for touchscreen devices of the present application.", "The method may include using a processor to execute sets of instructions saved in a non-transitory computer-readable medium to conduct the following steps: Step 301: combining two or more single-function buttons on a user interface of the touchscreen device into one multifunction button.", "When implementing the embodiment of the present invention, the processor may first combine several single-function buttons on the user interface of the touchscreen device into one multifunction button.", "For example, the processor may combine several single-function buttons on the top or bottom of the touchscreen device into one multifunction button.", "A default location of the multifunction button may be preset at the central bottom location of the touchscreen device.", "FIG.", "4 is a schematic diagram showing that a default location of the multifunction button 410 may be preset at the central bottom of a touchscreen 420 of a device 400.Step 302: monitoring a real-time touch operation on the multifunction button conducted by the user.", "In this step, the processor may monitor in real time whether the user has conducted and/or is conducting a touch operation with the multifunction button.", "If yes, the processor may start a timer to detect the time of the touch operation on the multifunction button conducted by the user.", "Step 303: determining the type of the touch operation according to the time of the touch operation.", "In practical use, a user may conduct long-press, short-press or double-click the multifunction button.", "Therefore, there may be several types of touch operation in this step.", "For example, Type I touch operation may be defined as short press, Type II touch operation may be defined as long press, Type III touch operation may be defined as double click, and Type IV touch operation may be defined as another type of touch operation and so on.", "Because in practical use common operations are mainly long press and short press, example embodiments in the present application only distinguish two types of touch operation: Type I touch operation and Type II touch operation.", "However, the spirit of the example embodiments should also be applied to situations that include more than two types of touch operations.", "As shown in FIG.", "5, conducting step 303 may require the processor conduct the following steps: Step 501: judging whether the time of the touch operation satisfies preset conditions of Type I touch operation.", "If it does, the processor may proceed to step 502; if not, the processor may proceed to step 503.The preset conditions may be set according to whether Type I touch operation is defined as a long press or a short press.", "For example, if Type I touch operation is defined as a short press, the preset conditions may be set as short press time.", "Step 502: determining the type of the touch operation as the Type I touch operation.", "If the time of the touch operation satisfies the time requirements of Type I touch operation, the processor may determine the type of the touch operation as Type I touch operation.", "Step 503: determining the type of the touch operation as the Type II touch operation.", "If the time of the touch operation fails the time requirements of Type I touch operation, the processor may determine the type of the touch operation as Type II touch operation.", "This example is only represented when there are two touch operation types.", "In situations where there are more than two types of touch operation, those skilled in the art may make corresponding adjustment and/or amend the steps above accordingly in order to distinguish all types of touch operation.", "To make those skilled in the art understand the implementation of the present application, illustrations are made below based on the situation that Type I touch operation is short press and the Type II touch operation is long press.", "Accordingly, the step 302 may include the following steps as shown in FIG.", "6: Step 601: judging, by the processor, whether the time of the touch operation is greater than a preset first threshold value.", "If it does, the processor may proceed to step 602; if not, the processor may proceed to step 603.The preset first threshold value may be determined before step 601 and servers as a critical point to distinguish a long press touch from a short press touch.", "For example, the preset first threshold value may be 0.8 second (0.8 s).", "When implementing step 602, the touch operation time may be obtained by monitoring a touchesBegan event (i.e., the beginning of a touch operation) and a touchesEnded event (i.e., the end of the touch operation) of the UIView (i.e., the user interface).", "A timer may be started by the processor when the touchesBegan event is triggered and stopped by the processor when the touchesEnded event is triggered, and the operation time on the timer is the touch operation time.", "Step 602: determine the touch operation as long press.", "When the touch operation time is longer than the preset first threshold value (e.g., 0.8 s), the type of the touch operation by the user may be determined as long press.", "Step 603: determine the touch operation as short press.", "When the touch operation time is shorter than the preset first threshold value (e.g., 0.8 s), the type of the touch operation by the user may be determined as short press.", "It should be noted that when the touch operation time equals the preset first threshold value (e.g., 0.8 s), the type of the touch operation may be determined as long press or short press according to the actual situation which may be set by the user.", "Step 304: unfolding the two or more single-function buttons one after another around the multifunction button according to the type of the touch operation.", "In this step, the processor may unfold the two or more single-function buttons one after another around the multifunction button according to the type of the touch operation.", "The unfolding way may differ as the touch operation type changes.", "For example, when the touch operation is Type I touch operation, the processor may unfold the two or more single-function buttons one after another in a user touch area around the multifunction button directly; when the touch operation is Type II touch operation, the processor may first adjust a docking location (i.e., an actual location that a button is finally placed by the processor after a user moves the button from its original location on the touchscreen) of the multifunction button according to the movement operation of the multifunction button by the user.", "Then the processor may unfold the two or more single-function buttons one after another in the user touch area around the docking location of the multifunction button after it is moved.", "It should be understood that there are such examples in practical use as that when the user short-presses the multifunction button (that is, when Type I touch operation is short press), the processor may unfold the combined single-function buttons one after another around the multifunction button into an arc; and when the user long-presses the multifunction button (that is, when Type II touch operation is long press), the processor may monitor if the multifunction button is moved by the user from its original location, place the multifunction button to a docking location after it is moved by the user, and unfold the combined single-function buttons one after another around the docking location of the multifunction button.", "These actions may be conducted by the processor simultaneously or may be conduct by the processor one after another.", "The situation on user's long-pressing the multifunction button will be introduced in detail in embodiment 2 and embodiment 3.It should be noted that, according to the user's using habits or aesthetic measure, when short-pressing the multifunction button, the user may decide that the processor unfolds evenly the two or more single-function buttons into an arc according to a preset radius around the multifunction button, wherein the distances of any two neighboring single-function buttons of the two or more single-function buttons are equal and the distances from any of the two or more single-function buttons to the multifunction button are equal.", "FIG.", "7 is a schematic diagram of the interface when several single-function buttons are unfolded in the user interface, wherein FIG.", "7 illustrates 5 single-function buttons, and the distances of any two neighboring single-function buttons 401 are equal and the distances from any of single-function buttons 401 to the multifunction button 410 are equal.", "It should be noted that FIG.", "7 is just an example embodiment of the even unfolding of single-function buttons.", "The single-function buttons may also be unfolded at will around the multifunction button without limiting the distribution of the single-function buttons as long as the user can see these single-function buttons.", "In this example embodiment, the unfolding diameter of the single-function buttons may be ½to ⅔ of the diameter of the multifunction button, while the user may decide the size of the single-function buttons or multifunction button.", "This example embodiment is just an illustration.", "In addition, the number of the single-function buttons and that whether there will be background or words when the single-function buttons are unfolded and so on may be defined by the user himself.", "It should be noted that when the number of unfolded single-function buttons is more than a maximum number that is allowed to be displayed on the screen of the touchscreen device, the number of unfolded single-function buttons may be set according to the current location of the multifunction button.", "For example, when the multifunction button is on the left or right side, the number of single-function buttons may be no more than 6.When the number of single-function buttons exceeds 6, only 5 of the single-function buttons may be displayed and the last button (i.e., the 6th button displayed) may be a “Show More” button.", "When the user touches the “Show More” button, an action sheet and/or a menu may pop up for the user to choose from more actions provided thereon.", "When the multifunction button is on the bottom middle of the screen, the number of the buttons may be no more than 11 and when the number of single-function buttons exceeds 11, only 10 single-function buttons are displayed.", "The last button (i.e., the 10th button displayed) may be a “Show More” button.", "When the user touches the “Show More” button, an action sheet and/or a menu may pop up for the user to choose from more actions provided thereon.", "It should be understood that, in practical use, user may also set the multifunction button as a semitransparent button, which may not affect the screen display frame of the touchscreen device and may also achieve the effect of the example embodiment of the present application.", "In the example embodiment, after combining several single-function buttons into one multifunction button with the method above, users may not need to consider the location of every single-function button during the operation, instead, they may only need to operate with the multifunction button.", "In addition, as the combined single-function buttons are around the multifunction button, users may also control the screen of the single-function buttons they need to operate with by moving the multifunction button, which makes it convenient for users to use the single-function buttons on the touchscreen.", "Furthermore, with convenient operation, it will not increase the operation times on the touchscreen and thus may reduce the wear of the touchscreen of the touchscreen devices from users' operation.", "FIG.", "8 illustrates a flow chart of an embodiment 2 of the first user interface interactive method for touchscreen devices of the present invention.", "In this embodiment, the touch operation type may include Type I and Type II touch operation, wherein Type II touch operation is illustrated as long press and Type I touch operation is illustrated as short press.", "In this example embodiment (i.e., embodiment 2), the processor may execute sets of instructions stored in the non-transitory computer-readable medium to conduct the following steps: Step 801: combining two or more single-function buttons on the user interface of the touchscreen device into one multifunction button.", "Step 802: monitoring a real-time touch operation conducted by a user on the multifunction button.", "The implementation of step 801 and step 802 is similar to step 301 and step 302, respectively, in embodiment 1, as shown in FIG.", "3.Step 803: judging whether the time of the touch operation is longer than a preset first threshold value.", "If it is, the processor may determine that the touch operation type is long press.", "Step 804: determining the type of the touch operation as long press.", "After determining the type of the touch operation is long press, the processor may adjust the docking location of the multifunction button according to the movement operation of the multifunction button by the user, wherein step 805 to step 807 illustrate how to adjust the docking location of the multifunction button according to the movement operation of the multifunction button by the user.", "Step 805: monitoring if the user has moved the multifunction button to a new location different from its original location.", "If he does, the processor may proceed to step 806.In this step, the processor may also monitor whether the user moves the multifunction button when he long-presses the multifunction button.", "If he does, the location of the multifunction button is changed.", "Step 806: when the user stops the movement operation, obtaining the moved location of the multifunction button after it is moved.", "In this step, the processor may obtain the current moved location of the multifunction button when the user stops the movement operation.", "Because the user may move the multifunction button at will on the whole screen of the touchscreen device, the processor may monitor the current location of the multifunction button after the user has stopped the movement operation.", "Step 807: when the user stops the touch operation, determining the docking location of the multifunction button according to the area of the moved location on the user interface.", "If the user stops touching the multifunction button after stops moving the multifunction button, the processor may determine the docking location of the multifunction button according to its moved location as determined in step 806.For example, when the user stops dragging the multifunction button, the multifunction button may or may not just stop right in its docking location.", "Thus the processor may determine whether the multifunction button needs to dock on the left, middle, or right side of the user interface according to the area where its moved location is, for example, on the left, middle or right side of the user interface.", "Step 808: unfolding the two or more single-function buttons one after another around the docking location of the multifunction button.", "After the docking location of the multifunction button is determined, the two or more single-function buttons may be unfolded one after another around the docking location of the multifunction button.", "For example, the processor may unfold evenly the two or more single-function buttons into an arc according to the preset radius around the multifunction button, wherein the distances of any two neighboring single-function buttons of the two or more single-function buttons may be equal and the distances from any of the two or more single-function buttons to the multifunction button may be equal.", "FIG.", "9 is a schematic diagram showing unfolding single-function buttons when the docking location of the multifunction button is on the left side of the user interface.", "FIG.", "10 is a schematic diagram showing unfolding single-function buttons when the docking location of the multifunction button is on the right side of the user interface.", "It can be seen from FIGS.", "9-10 that after unfolding the single-function buttons, the single-function buttons are distributed evenly on an arc with the multifunction button as the center of the arc.", "The diameter of the arc is ½ of the screen height of the touchscreen device.", "When the multifunction button is on the left or right bottom of the screen, the single-function buttons form a 90-degree arc, and when the multifunction button is in the middle of the screen, the single-function buttons form a 180-degree arc.", "It should be noted that the diameter of the arc formed by unfolding single-function buttons may also be ⅓ of the screen height of the touchscreen device, or other numerical value, or a diameter preset by the user.", "It should be noted that, the multifunction button may be at any location on the screen of the touchscreen device and the single-function buttons may be unfolded in various ways such as being unfolded vertically or horizontally.", "The schematic diagrams in the example embodiment of the present application are only examples and should not be understood as all of the implementation models of the embodiment of the present application.", "In this embodiment, the user can move the multifunction button to the left, middle or right bottom of the screen by long-pressing the multifunction button so he can unfold the single-function buttons in a range convenient for his operation, which not only increases the utilization rate of the screen of the touchscreen device but also enhances user experience.", "FIG.", "11 shows a flow diagram of an embodiment 3 of the first user interface interactive method for touchscreen devices of the present application.", "In this example embodiment, touch operation type may include Type I touch operation and Type II touch operation, wherein Type II touch operation may be illustrated as long press and Type I touch operation may be illustrated as short press.", "The embodiment may require the processor execute sets of instructions stored in the non-transitory computer-readable medium to conduct the following steps: Step 1101: combining two or more single-function buttons on the user interface of the touchscreen device into one multifunction button.", "Step 1102: dividing a movable area (i.e., an area on the touchscreen on which the multifunction button may be movable) of the multifunction button on the user interface into three equal subareas; wherein the movable area may be a horizontal area located on the bottom of the touchscreen of the device.", "The movable area may have a height equals a preset second threshold value.", "The second threshold value may be modified according to the size of the multifunction button and may be generally fixed on the bottom of the touchscreen of the touchscreen device, for example, within the area with a height of 44 pixels above the bottom of the screen and a width of the screen bottom horizontal line, which is called the movable area of the multifunction button.", "The processor may divide the movable area into three equal subareas A (left side), B (middle) and C (right side).", "Step 1103: determining the center coordinates of the three subareas.", "The processor may set the center coordinates of the three subareas as the final docking locations of the multifunction function button in the three subareas—a (center coordinate of subarea A), b (center coordinate of subarea B) and c (center coordinate of subarea C).", "Step 1104: monitoring the real-time touch operation of the multifunction button by the user.", "Step 1105: judging whether the time of the touch operation is greater than the preset first threshold value.", "Step 1106: determining the touch operation as long press.", "Step 1107: monitoring whether the user has moved the multifunction button.", "If he does, the processor may proceed to step 1108.Step 1108: when the user stops the movement operation, detecting whether the multifunction button is out of the movable area in the vertical direction during the movement.", "If it is, the processor may proceed to step 1109.Because the user may move the multifunction button at will, the processor may detect whether the multifunction button is out of the movable area in the vertical direction after the user stops moving the multifunction button.", "If yes, the processor may automatically correct the location of the multifunction button later.", "Step 1109: correcting the vertical coordinate of the move location of the multifunction button after it is moved to the second threshold value of the movable area, and remaining the horizontal coordinate of the moved location the same as that of the location after it is moved.", "Because the location of the multifunction button will not just stop at a, b or c when the user stops dragging the multifunction button, the processor may check which area of A, B or C the coordinate of the multifunction button is in, and its final docking point may be determined as the center coordinate point of the current area.", "When the coordinate of the multifunction button is not out of the movable area, the center coordinate of the multifunction button may be the coordinate of the multifunction button in its current move location; when the coordinate of the multifunction button is out of the movable area, the X value (i.e., the value of the horizontal coordinate) in the horizontal direction of the center coordinate of the multifunction button may be kept the same as the X value of the current move location, but the Y value (i.e., the value of the vertical coordinate) in the vertical direction may be the Y value that the move location of the multifunction button maps on the upper boundary of the movable area.", "Accordingly, the processor may automatically correct the deviation that the multifunction button exceeds its movable range when the user long-presses and moves the multifunction button, which means that, when the multifunction button moves on the bottom of the touchscreen device, the move direction depends on the move direction of the multifunction button on the horizontal line, while the move distance on the straight-line distance of the multifunction button in the horizontal direction.", "It should be noted that, the horizontal and vertical directions specified in the embodiment of the present invention are relative directions with the bottom horizontal line when the touchscreen device is placed in forward direction.", "Step 1110: determining the docking location of the multifunction button as the center coordinate point of the current subarea according to the current subarea where the move location is located.", "For example, if the current subarea where the move location of the multifunction button is located is subarea A, the docking location of the multifunction button may be determined as point a.", "Step 1111: unfolding the two or more single-function buttons one after another around the docking location of the multifunction button.", "It should be noted that, when unfolding the single-function buttons in this step, three corresponding animations may be set according to the docking location of the multifunction button and each may include the movement of the locations of the single-function buttons and the rotation of the angle of the single-function buttons as well as the dissolving effect of the single-function buttons.", "Each single-function button may correspond to an animation path from its starting location to its ending location, and the animation path may be accompanied by the spinning effect of the single-function button.", "A simple animation may also be used to present the process that the multifunction button moves from the move location to the docking location.", "The duration may be limited to 0.2 s. It should be understood that, during the animation playing process, the multifunction button may not respond to touch operation conducted by the user anymore and may only respond to the touch operation after the animation is ended.", "It should be noted that, the unfolded single-function button may have both a starting location and an ending location when the multifunction button is in different positions.", "The starting location of each single-function button may be fixed, which may be the center coordinate of the multifunction button, while the ending location should be referred to the arc arrangement specified above.", "The animation of the single-function buttons may be the combination of the animation of each single-function button from its starting location to its ending location.", "The animation mainly may include two parts: one is the movement of the location and the other is the spinning of the single-function button itself.", "The time of the animation may be set as being equally split, i.e., the content of the animation may be equally distributed according to the time.", "For example, the spinning starts when the single-function button is moved to the starting location and ends when it arrives the ending point.", "The animation of the single-function button may also be set as the animation style that supports customized definition, in which, user only needs to define an AnimationGroup object in IOS.", "It should be understood that the play time of the animation of single-function buttons may be set as 0.5 s, and the interval of the animal starting time of each single-function button may be 0.1 s, which may ensure that the complete animation of tall single-function buttons be ended in 1 s. So it will not affect user experience and also makes it convenient for user operation.", "The numerical values in the embodiment of the present invention are examples made for easy understanding by those skilled in the art.", "Those skilled in the art may choose other numerical values by themselves without contributing any creative labor.", "A second user interface interactive method for touchscreen devices may also be provided in the embodiment of the present application, as shown in FIG.", "12.This embodiment may require the processor execute sets of instructions stored in the non-transitory computer-readable medium to conduct the following steps: Step 1201: combining two or more single functions on the user interface of the touchscreen device into one multifunction button, and monitoring the real-time touch operation on the multifunction button by the user.", "Step 1202: determining the type of the touch operation according to the time of the touch operation.", "In this embodiment, the implementation of step 1201 and step 1202 may be referred to embodiment 1, embodiment 2, and embodiment 3 of the first user interface interactive method for touchscreen devices as described above.", "Step 1203: judging whether the type of the touch operation satisfies the preset conditions to move the multifunction button.", "If it does, the processor may proceed to step 1204; if not, the processor may proceed to step 1205.In this step, the difference from the first user interface interactive method for touchscreen devices may be judging whether the type of the touch operation satisfies the preset conditions to move the multifunction button.", "For example, when the type of the touch operation is long press, it is deemed that it satisfies the preset conditions to move the multifunction button.", "However, those skilled in the art and/or a user may change the preset conditions according to the actual scene.", "For example, it may be set as that, when the user double-clicks the multifunction button, it is deemed that it satisfies the preset conditions to move the multifunction button; Step 1204: determining the docking location of the multifunction button according to the movement operation of the multifunction button by the user.", "If it satisfies the preset conditions to move the multifunction button, the processor may determine the final docking location of the multifunction button according to the movement operation of the multifunction button by the user, wherein the solution on how to determine the docking location may be referred to embodiment 2 and embodiment 2 of the first user interface interactive method for touchscreen devices, as set forth above.", "Step 1205: unfolding the two or more single-function buttons one after another around the multifunction button.", "If it does not satisfy the preset conditions to move the multifunction button, the processor may unfold the two or more single-function buttons around the multifunction button directly.", "It should be noted that, the implementation of the steps in this embodiment may be referred to those in embodiment 1, embodiment 2, and embodiment 3 of the first user interface interactive method for touchscreen devices, so it is unnecessary to go into details here.", "Through the description of the embodiments above, those skilled in the art may understand that the present application may be embodied in the form of a software and/or hardware product.", "The computer software product is stored in a computer-readable storage medium including a number of instructions that make a computer equipment (which can be a PC, a server, or network equipment and so on) implement all or part of the steps of the methods in the embodiments of the present application.", "While the storage medium may include, but not limited to, ROM, RAM, disk or optical disk or other medium that can store program codes.", "Corresponding to the method embodiment above, the embodiment of the present application also provides a first user interface interactive device for touchscreen devices.", "FIG.", "13 shows a structural schematic diagram of an embodiment 1 of the first user interface interactive device for touchscreen devices, which may comprise: a combination module 1301 being configured to combine two or more single-function buttons on the user interface of the touchscreen device into one multifunction button; a monitoring module 1302 being configured to monitor the real-time touch operation of the multifunction button by the user; and a first determination module 1303 being configured to determine the type of the touch operation according to the time of the touch operation; wherein the type of the touch operation may include Type I touch operation and Type II touch operation.", "As shown in FIG.", "14, the first determination module 1303 may comprises: a first judgment submodule 1401 being configured to judge whether the time of the touch operation satisfies the preset conditions of Type I touch operation; Type I touch operation is short press and Type II touch operation is long press.", "The first judgment submodule may be configured to: judge whether the time of the touch operation is longer than a preset first threshold value; a first determination submodule 1402, which may be configured to determine the type of the touch operation as the Type I touch operation when the result of the judgment submodule is yes; a second determination submodule 1403, which may be configured to determine the type of the touch operation as the Type II touch operation when the result of the judgment submodule is no; an interaction module 1304, which may be configured to unfold the two or more single-function buttons one after another around the multifunction button according to the type of the touch operation.", "As shown in FIG.", "15, the interaction module 1304 may comprise a first interaction submodule 1501, an adjustment submodule 1502, and a second interaction submodule 1503, wherein when the touch operation is Type I touch operation, the first interaction submodule 1501 may be configured to unfold the two or more single-function buttons one after another in the user touch area around the multifunction button; The first interaction submodule 1501 may be configured to unfold evenly the two or more single-function buttons into an arc according to the preset radius around the multifunction button, wherein the distances of any two neighboring single-function buttons of the two or more single-function buttons may be equal and the distances from any of the two or more single-function buttons to the multifunction button may be equal; When the touch operation is Type II touch operation, the adjustment submodule 1502 may be configured to adjust the docking location of the multifunction button according to the movement operation of the multifunction button by the user; and The second interaction submodule 1503 may be configured to unfold the two or more single-function buttons one after another in the user touch area around the docking location of the multifunction button after it is moved.", "In this embodiment, when operating the touchscreen device, users do not need to consider the location of every single-function button in the current technology during the operation, instead, they only need to operate with the multifunction button.", "In addition, as the combined single-function buttons are around the multifunction button, users may also control the screen of the single-function buttons they need to operate with by moving the multifunction button, which makes it convenient for users to use the single-function buttons on the touchscreen.", "Furthermore, with convenient operation, it will not increase the operation times on the touchscreen and thus will reduce the wear of the touchscreen of the touchscreen devices from users' operation.", "FIG.", "16 shows a structural schematic diagram of an embodiment 2 of the first user interface interactive device for touchscreen devices.", "The touch operation type may include Type I touch operation and Type II touch operation, wherein Type II touch operation may be illustrated as long press.", "The device in the embodiment may comprise: a combination module 1301, which may be configured to combine two or more single-function buttons on the interface of the touchscreen device into one multifunction button; a monitoring module 1302, which may be configured to monitor the real-time touch operation of the multifunction button by the user; a first determination module 1303, which may be configured to determine the type of the touch operation according to the time of the touch operation.", "When the touch operation is Type II touch operation, the adjustment submodule 1502 may comprise: a monitoring submodule 1601, which may be configured to monitor whether the user has moved the multifunction button; when the result of the monitoring submodule 1601 is yes, the obtaining submodule 1602, which may be used when the user stops the movement operation, may be configured to obtain the location of the multifunction button after it is moved; a third determination submodule 1603, which may be configured to determine the docking location of the multifunction button according to the area of the move location on the user interface when the user stops the touch operation.", "The second interaction submodule 1503 may be configured to unfold evenly the two or more single-function buttons into an arc according to the preset radius in the user touch area around the docking location of the multifunction button, wherein distances of any two neighboring single-function buttons of the two or more single-function buttons may be equal and the distances from any of the two or more single-function buttons to the multifunction button may be equal.", "In this embodiment, the user may move the multifunction button to the left, middle or right bottom of the screen by long-pressing the multifunction button so he may unfold the single-function buttons in a range convenient for his operation, which not only increases the utilization rate of the screen of the touchscreen device but also enhances user experience.", "FIG.", "17 shows a structural schematic diagram of an embodiment 3 of the first user interface interactive device for touchscreen devices.", "The touch operation type may include Type I touch operation and Type II touch operation, wherein Type II touch operation may be illustrated as long press.", "The device in the embodiment may comprise: a combination module 1301, which may be configured to combine two or more single-function buttons on the user interface of the touchscreen device into one multifunction button; a trisection module 1701, which may be configured to divide the movable area of the multifunction button on the user interface into three equal subareas; wherein the movable area may be a horizontal area located on the bottom of the touchscreen device and its height may equals to the preset second threshold value; a second determination module 1702, which is used to may be configured to determine the center coordinate points of the three subareas; a monitoring module 1302, which may be configured to monitor the real-time touch operation of the multifunction button by the user.", "a monitoring submodule 1601, which may be configured to monitor whether the user has moved the multifunction button; when the result of the monitoring submodule 1601 is yes, in this embodiment, the obtaining submodule 1602 may comprise: a detection submodule 1703, which may be configured to detect whether the current multifunction button is out of the movable area in the vertical direction during its movement; a correction submodule 1704, which may be configured to correct the vertical coordinate of the move location of the multifunction button after it is moved, to the second threshold value of the movable area, while the horizontal coordinate of the move location is the same as that of the location after it is moved; a third determination submodule 1603, which may be configured to determine the docking location of the multifunction button as the center coordinate point of the current subarea according to the current subarea where the move location is located; and an interaction module 1304, which may be configured to unfold the two or more single-function buttons one after another around the docking location of the multifunction button according to the type of the touch operation.", "FIG.", "18 shows a structural schematic diagram of an embodiment of the second user interface interactive device for touchscreen devices which may comprise: a combination module 1301, which may be configured to combine two or more single-function buttons on the user interface of the touchscreen device into one multifunction button; a monitoring module 1302, which may be configured to monitor the real-time touch operation of the multifunction button by the user; a first determination module 1303, which may be configured to determine the type of the touch operation according to the time of the touch operation; a judgment module 1801, which may be configured to judge whether the type of the touch operation satisfies the preset conditions to move the multifunction button; a second determination module 1802, which may be configured to determine the docking location of the multifunction button according to the user's movement operation of the multifunction button when the result of the judgment module is yes; and an unfolding module 1803, which may be configured to unfold one after another the two or more single-function buttons around the multifunction button when the result of the judgment module is no.", "It should be noted that the modules set forth above may be hardware structures in the touchscreen devices of the present application.", "The modules may also be hardware module embedded in the processor.", "The modules may also be instructions stored in the non-transitory computer-readable storage medium and may be executed by the processor.", "To the device embodiment, as it is basically corresponding to the method embodiment, please refer to the description of the method embodiment for relevant steps.", "The device embodiment described above is just a schematic embodiment, wherein the units that are illustrated as separated parts may be or may not be separated physically, and the components displayed as units may be or may not be physical units, that is, they can be located in the same place or distributed in several network elements.", "Part or all of the modules may be selected to achieve the goal of the embodiment according to the actual demand.", "Those skilled in the art may understand and implement the embodiment without contributing any creative labor.", "A touchscreen device is also disclosed in the embodiment of the present invention.", "The touchscreen device may be any one of the user interface interactive device disclosed above.", "It should be understood that, the present invention can be used in many general or special-purpose computer system environments or configurations, such as PC, server computer, handheld device or portable device, tablet device, multiprocessor system, microprocessor-based system, set-top box, programmable consumer electronics, network PC, small-size computer, large-scale computer and the distributed computing environment that includes any of the systems or equipment above and so on.", "The present invention can be described in the general context of the executable instruction executed by the computer, such as program module.", "Generally, program module includes routine, program, object, component and data structure and so on that execute specific tasks or realize specific abstract data types.", "The present invention can also be practiced in distributed computing environments.", "In those distributed computing environments, tasks are executed by remote process equipment connected through communication network.", "In distributed computing environments, program modules can be located in the local and remote computer storage mediums including storage devices.", "It should be noted that, the relation terms like first and second, as used herein, are only used to distinguish one entity or operation from another and are not necessarily required to or indicating any actual such relation or order between those entities or operations.", "Moreover, the terms “include” “comprise” or any other variant means non-exclusive comprising, so comprising or including the processes, methods, objects or equipment of a series of elements means there are not only those elements included but also other elements that are not listed or means they also include the inherent elements of those processes, methods, objects or equipment.", "Without more restrictions, the elements limited by the phrase “including one .", ".", ".", "” does not rule out the possibility that there are other identical elements in the processes, methods, objects or equipment of the element.", "The invention has been described in terms of various specific embodiments.", "It should be pointed out that those skilled in the art may make various changes and modifications on those embodiments without deviating from the principles of the present invention and those changes and modifications should be within the scope of protection of the present invention." ] ]
Patent_15874385
[ [ "CLINICAL CONTENT-DRIVEN ARCHITECTURE SYSTEMS AND METHODS OF USE", "Certain examples provide methods, systems and apparatus of content-driven clinical information management.", "An example method includes facilitating authoring of content and combination of the content into a content-based application, wherein content represents a parameterization of instructions to instruct the content-based application how to operate, the content formulated according to one or more detailed clinical models.", "The example method includes packaging and deploying the content-based application using a processor to one or more targets for installation.", "The example method includes facilitating installation of the packaged content-based application at the one or more targets.", "The example method includes managing the content-based application remotely from the one or more targets.", "In the example method, content is to be created, stored, deployed, and retrieved independently of the creation and deployment of the content-based application consuming data based on the content." ], [ "1.A method of forming a content-based application for execution, the method comprising: receiving, by a processor, an identifier for a root content item and an association between the root content item and a context variant; dynamically generating, by the processor, a content-based application by: generating a first content frame from the context variant, the context variant retrieved using the identifier for the root content item associated with the first content frame and the association between the root content item and the context variant corresponding to the first content frame; and combining the first content frame and a second content frame according to one or more element models to form the content-based application; and deploying, by the processor, the content-based application for execution with respect to data via a reference platform.", "2.The method of claim 1, wherein the context variant corresponding to the first content frame provides content including a parameterization of instructions governing execution of the content-based application.", "3.The method of claim 2, wherein the content includes at least one of configuration content, preference content, reference content, or application content.", "4.The method of claim 1, wherein the reference platform includes a content class interpreter, a content class manager, and a reference platform service, the content-based application to execute with respect to the reference platform at runtime.", "5.The method of claim 4, wherein the reference platform and the content-based application are independently scalable and modifiable.", "6.The method of claim 1, wherein the context variant is associated with a state and wherein the state is associated with a workflow to control a transition to a next state.", "7.The method of claim 1, wherein dynamically generating the content-based application further includes organizing the first content frame and the second content frame into a first formlet, the first formlet and a second formlet to form the content-based application.", "8.A computer-readable storage medium including instructions which, when executed by a processor, cause the processor to at least implement a method of forming a content-based application for execution, the method comprising: receiving an identifier for a root content item and an association between the root content item and a context variant; dynamically generating a content-based application by: generating a first content frame from the context variant, the context variant retrieved using the identifier for the root content item associated with the first content frame and the association between the root content item and the context variant corresponding to the first content frame; and combining the first content frame and a second content frame according to one or more element models to form the content-based application; and deploying the content-based application for execution with respect to data via a reference platform.", "9.The computer-readable storage medium of claim 8, wherein the context variant corresponding to the first content frame provides content including a parameterization of instructions governing execution of the content-based application.", "10.The computer-readable storage medium of claim 9, wherein the content includes at least one of configuration content, preference content, reference content, or application content.", "11.The computer-readable storage medium of claim 8, wherein the reference platform includes a content class interpreter, a content class manager, and a reference platform service, the content-based application to execute with respect to the reference platform at runtime.", "12.The computer-readable storage medium of claim 11, wherein the reference platform and the content-based application are independently scalable and modifiable.", "13.The computer-readable storage medium of claim 8, wherein the context variant is associated with a state and wherein the state is associated with a workflow to control a transition to a next state.", "14.The computer-readable storage medium of claim 8, wherein dynamically generating the content-based application further includes organizing the first content frame and the second content frame into a first formlet, the first formlet and a second formlet to form the content-based application.", "15.An apparatus comprising: a memory to store instructions, content and data; and a processor, wherein the instructions, when executed by the processor, configure the processor to facilitate formation of a content-based clinical application by at least: dynamically generating, using an identifier for a root content item and an association between the root content item and a context variant, a content-based application by: generating a first content frame from the context variant, the context variant retrieved using the identifier for the root content item associated with the first content frame and the association between the root content item and the context variant corresponding to the first content frame; and combining the first content frame and a second content frame according to one or more element models to form the content-based application; and deploying the content-based application for execution with respect to data via a reference platform.", "16.The apparatus of claim 15, wherein the context variant corresponding to the first content frame provides content including a parameterization of instructions governing execution of the content-based application.", "17.The apparatus of claim 15, wherein the reference platform includes a content class interpreter, a content class manager, and a reference platform service, the content-based application to execute with respect to the reference platform at runtime.", "18.The apparatus of claim 17, wherein the reference platform and the content-based application are independently scalable and modifiable.", "19.The apparatus of claim 15, wherein the context variant is associated with a state and wherein the state is associated with a workflow to control a transition to a next state.", "20.The apparatus of claim 15, wherein the first content frame and the second content frame are to be organized into a first formlet, the first formlet and a second formlet to form the content-based application." ], [ "<SOH> BACKGROUND <EOH>Healthcare environments, such as hospitals and clinics, typically include information systems (e.g., electronic medical record (EMR) systems, lab information systems, outpatient and inpatient systems, hospital information systems (HIS), radiology information systems (RIS), storage systems, picture archiving and communication systems (PACS), etc.)", "to manage clinical information such as, for example, patient medical histories, imaging data, test results, diagnosis information, management information, financial information, and/or scheduling information.", "These healthcare information systems are used to implement different types of workflows in which clinical information is generated, updated, augmented, and/or otherwise processed for one or more purposes." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 is a block diagram of an example healthcare environment in which the example methods, apparatus, systems, and/or articles of manufacture disclosed herein for clinical content-based healthcare may be implemented.", "FIG.", "2 illustrates an example clinical knowledge system providing an aggregation of data from multiple sources.", "FIG.", "3 illustrates an example interdependence of content types.", "FIG.", "4 illustrates an example hierarchy of content, associated data models, and terminology.", "FIG.", "5 shows an example root content item having one or more content variants which may be associated with one or more context variants.", "FIG.", "6 provides an example multi-patient view (MPV) including a plurality of formlets and a frameset.", "FIG.", "7 illustrates an example content management process.", "FIG.", "8 , consisting of FIGS.", "8 a - 8 c, shows a deployment example in which a plurality of models in a content package are deployed to create a content frame.", "FIG.", "9 provides an example of namespaces A, B, and C including various content items (CIs).", "FIG.", "10 depicts an example of a state versus a workflow.", "FIG.", "11 , consisting of FIGS.", "11 a - 11 d, illustrates an example clinical information system including a reference platform and one or more content items that define clinical functionality.", "FIG.", "12 illustrates an example of runtime context resolution using an input context and a pool of variants.", "FIG.", "13 shows an example in which conflicting variants are rejected.", "FIG.", "14 shows an example in which more specific context variants are rejected.", "FIG.", "15 shows an example in which, of remaining variants, a most specific variant to an input context is accepted to resolve the input context into a context variant.", "FIGS.", "16-18 provide examples of runtime context resolution.", "FIG.", "19 illustrates an example in which context resolution may occur at packaging time.", "FIG.", "20 illustrates an example in which conflicting context variants are rejected.", "FIG.", "21 shows conflicting context variants that may be further eliminated based on an input context at packaging time.", "FIGS.", "22-23 , consisting of FIGS.", "22 a -22 g and FIGS.", "23 a - 23 i, respectively, illustrate example content management services systems.", "FIG.", "24 illustrates a flow diagram for an example method of creating and managing a clinical application in a content-based system.", "FIG.", "25 illustrates a flow diagram for an example method of content-driven clinical information management.", "FIG.", "26 illustrates a flow diagram for an example method of heuristic content resolution in an extensible content management system.", "FIG.", "27 is a block diagram of an example processor system that may be used to implement the apparatus and methods described herein.", "detailed-description description=\"Detailed Description\" end=\"lead\"?", "The foregoing summary, as well as the following detailed description of certain implementations of the methods, apparatus, systems, and/or articles of manufacture described herein, will be better understood when read in conjunction with the appended drawings.", "It should be understood, however, that the methods, apparatus, systems, and/or articles of manufacture described herein are not limited to the arrangements and instrumentality shown in the attached drawings." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This patent claims priority to U.S. Non-Provisional application Ser.", "No.", "13/401,057, entitled “CLINICAL CONTENT-DRIVEN ARCHITECTURE SYSTEMS AND METHODS OF USE,”, filed on Feb. 21, 2012, which claims the benefit of priority to Provisional Application Serial No.", "61/444,961, entitled “Clinical Content-Driven Architecture Systems and Methods of Use,” which was filed on Feb. 21, 2011, both of which are hereby incorporated by reference in their entireties.", "FIELD OF THE DISCLOSURE The present disclosure relates generally to healthcare information systems and, more particularly, to methods and apparatus for content-driven systems and methods.", "BACKGROUND Healthcare environments, such as hospitals and clinics, typically include information systems (e.g., electronic medical record (EMR) systems, lab information systems, outpatient and inpatient systems, hospital information systems (HIS), radiology information systems (RIS), storage systems, picture archiving and communication systems (PACS), etc.)", "to manage clinical information such as, for example, patient medical histories, imaging data, test results, diagnosis information, management information, financial information, and/or scheduling information.", "These healthcare information systems are used to implement different types of workflows in which clinical information is generated, updated, augmented, and/or otherwise processed for one or more purposes.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a block diagram of an example healthcare environment in which the example methods, apparatus, systems, and/or articles of manufacture disclosed herein for clinical content-based healthcare may be implemented.", "FIG.", "2 illustrates an example clinical knowledge system providing an aggregation of data from multiple sources.", "FIG.", "3 illustrates an example interdependence of content types.", "FIG.", "4 illustrates an example hierarchy of content, associated data models, and terminology.", "FIG.", "5 shows an example root content item having one or more content variants which may be associated with one or more context variants.", "FIG.", "6 provides an example multi-patient view (MPV) including a plurality of formlets and a frameset.", "FIG.", "7 illustrates an example content management process.", "FIG.", "8, consisting of FIGS.", "8a-8c, shows a deployment example in which a plurality of models in a content package are deployed to create a content frame.", "FIG.", "9 provides an example of namespaces A, B, and C including various content items (CIs).", "FIG.", "10 depicts an example of a state versus a workflow.", "FIG.", "11, consisting of FIGS.", "11a-11d, illustrates an example clinical information system including a reference platform and one or more content items that define clinical functionality.", "FIG.", "12 illustrates an example of runtime context resolution using an input context and a pool of variants.", "FIG.", "13 shows an example in which conflicting variants are rejected.", "FIG.", "14 shows an example in which more specific context variants are rejected.", "FIG.", "15 shows an example in which, of remaining variants, a most specific variant to an input context is accepted to resolve the input context into a context variant.", "FIGS.", "16-18 provide examples of runtime context resolution.", "FIG.", "19 illustrates an example in which context resolution may occur at packaging time.", "FIG.", "20 illustrates an example in which conflicting context variants are rejected.", "FIG.", "21 shows conflicting context variants that may be further eliminated based on an input context at packaging time.", "FIGS.", "22-23, consisting of FIGS.", "22a-22g and FIGS.", "23a-23i, respectively, illustrate example content management services systems.", "FIG.", "24 illustrates a flow diagram for an example method of creating and managing a clinical application in a content-based system.", "FIG.", "25 illustrates a flow diagram for an example method of content-driven clinical information management.", "FIG.", "26 illustrates a flow diagram for an example method of heuristic content resolution in an extensible content management system.", "FIG.", "27 is a block diagram of an example processor system that may be used to implement the apparatus and methods described herein.", "The foregoing summary, as well as the following detailed description of certain implementations of the methods, apparatus, systems, and/or articles of manufacture described herein, will be better understood when read in conjunction with the appended drawings.", "It should be understood, however, that the methods, apparatus, systems, and/or articles of manufacture described herein are not limited to the arrangements and instrumentality shown in the attached drawings.", "BRIEF DESCRIPTION Certain examples provide a method of content-driven clinical information management.", "The example method includes facilitating, using a processor, authoring of content and combination of the content into a content-based application, wherein content represents a parameterization of instructions to instruct the content-based application how to operate, the content formulated according to one or more detailed clinical models.", "The example method includes packaging and deploying the content-based application using a processor to one or more targets for installation.", "The example method includes facilitating installation of the packaged content-based application at the one or more targets.", "The example method includes managing the content-based application remotely from the one or more targets.", "In the example method, content is to be created, stored, deployed, and retrieved independently of the creation and deployment of the content-based application consuming data based on the content.", "Certain examples provide a tangible computer-readable storage medium including computer program code which, when executed, implements a method of content-driven clinical information management.", "The example method includes facilitating, using a processor, authoring of content and combination of the content into a content-based application, wherein content represents a parameterization of instructions to instruct the content-based application how to operate, the content formulated according to one or more detailed clinical models.", "The example method includes packaging and deploying the content-based application using a processor to one or more targets for installation.", "The example method includes facilitating installation of the packaged content-based application at the one or more targets.", "The example method includes managing the content-based application remotely from the one or more targets.", "In the example method, content is to be created, stored, deployed, and retrieved independently of the creation and deployment of the content-based application consuming data based on the content.", "DETAILED DESCRIPTION Although the following discloses example methods, apparatus, systems, and articles of manufacture including, among other components, firmware and/or software executed on hardware, it should be noted that such methods, apparatus, systems, and/or articles of manufacture are merely illustrative and should not be considered as limiting.", "For example, it is contemplated that any or all of these firmware, hardware, and/or software components could be embodied exclusively in hardware, exclusively in software, exclusively in firmware, or in any combination of hardware, software, and/or firmware.", "Accordingly, while the following describes example methods, apparatus, systems, and/or articles of manufacture, the examples provided are not the only way(s) to implement such methods, apparatus, systems, and/or articles of manufacture.", "Entities of healthcare enterprises operate according to a plurality of clinical workflows.", "Clinical workflows are typically defined to include one or more steps or actions to be taken in response to one or more events and/or according to a schedule.", "Events may include receiving a healthcare message associated with one or more aspects of a clinical record, opening a record(s) for new patient(s), receiving a transferred patient, and/or any other instance and/or situation that requires or dictates responsive action or processing.", "The actions or steps of a clinical workflow may include placing an order for one or more clinical tests, scheduling a procedure, requesting certain information to supplement a received healthcare record, retrieving additional information associated with a patient, providing instructions to a patient and/or a healthcare practitioner associated with the treatment of the patient, and/or any other action useful in processing healthcare information.", "The defined clinical workflows can include manual actions or steps to be taken by, for example, an administrator or practitioner, electronic actions or steps to be taken by a system or device, and/or a combination of manual and electronic action(s) or step(s).", "While one entity of a healthcare enterprise may define a clinical workflow for a certain event in a first manner, a second entity of the healthcare enterprise may define a clinical workflow of that event in a second, different manner.", "In other words, different healthcare entities may treat or respond to the same event or circumstance in different fashions.", "Differences in workflow approaches may arise from varying preferences, capabilities, requirements or obligations, standards, protocols, etc.", "among the different healthcare entities.", "However, the entities of a healthcare enterprise and/or entities from separate healthcare enterprises sometimes operate within a broader, interdependent information system, which hinder the ability of entities to customize clinical workflows.", "For example, the information system to which a healthcare entity belongs may place restrictions on changes to workflow applications or programs.", "Moreover, because some healthcare entities operate using systems, programs, devices, etc.", "from varying manufacturers, software providers, etc., a lack of interoperability between the systems, programs, devices, etc.", "of each healthcare entity prohibits many customizations from realization.", "As a consequence of these example factors as well as additional or alternative factors, healthcare entities that desire customized clinical workflows are typically required to request such customizations from the manufacturers, software providers, etc.", "Furthermore, for such customizations to implemented or integrated into a healthcare information system, a wide range of system-interrupting updates or re-releases occur within the information systems.", "Certain examples provide a clinical knowledge platform that enables healthcare institutions to improve performance, reduce cost, touch more people, and deliver better quality globally.", "In certain examples, the clinical knowledge platform enables healthcare delivery organizations to improve performance against their quality targets, resulting in better patient care at a low, appropriate cost.", "Certain examples facilitate better control over data.", "For example, certain example systems and methods enable care providers to access real-time patient information from existing healthcare information technology (IT) systems together in one location and compare this information against evidence-based best practices.", "Certain examples facilitate better control over process.", "For example, certain example systems and methods provide condition- and role-specific patient views enable a user to prioritize and coordinate care efforts with an institution's agreed upon practice standards and to more effectively apply resources.", "Certain examples facilitate better control over outcomes.", "For example, certain example systems and methods provide patient dashboards that highlight variations from desired practice standards and enable care providers to identify most critical measures within the context of performance-based care.", "Certain examples leverage existing IT investments to standardize and centralize data across an organization.", "In certain examples, this includes accessing multiple systems from a single location, while allowing greater data consistency across the systems and users.", "In certain examples, an advanced Service-Oriented Architecture (SOA) with a modern technology stack helps provide robust interoperability, reliability, and performance.", "The example SOA includes a three-fold interoperability strategy including a central repository (e.g., a central repository built from Health Level Seven (HL7) transactions), services for working in federated environments, and visual integration with third-party applications.", "Certain examples provide portable content enabling plug 'n play content exchange among healthcare organizations.", "A standardized vocabulary using common standards (e.g., LOINC, SNOMED CT, RxNorm, FDB, ICD-9, ICD-10, etc.)", "is used for interoperability, for example.", "Certain examples provide an intuitive user interface to help minimize end-user training.", "Certain examples facilitate user-initiated launching of third-party applications directly from a desktop interface to help provide a seamless workflow by sharing user, patient, and/or other contexts.", "Certain examples provide real-time (or at least substantially real time assuming some system delay) patient data from one or more IT systems and facilitate comparison(s) against evidence-based best practices.", "Certain examples provide one or more dashboards for specific sets of patients.", "Dashboard(s) can be based on condition, role, and/or other criteria to indicate variation(s) from a desired practice, for example.", "Generally, the example methods, apparatus, systems, and/or articles of manufacture disclosed herein enable healthcare entities of an enterprise clinical information system (ECIS) to dynamically customize one or more clinical workflows.", "Among other functions and/or benefits, the ECIS supports healthcare practitioners in decision making processes by aggregating healthcare information across disparate enterprises and/or entities thereof and referencing collection(s) of data (e.g., guidelines, recommendations related treatment and/or diagnosis, studies, histories, etc.)", "to automatically generate supportive information to be communicated to one or more healthcare practitioners related to the aggregated healthcare information.", "While each entity operates in connection with the ECIS that is administered by a provider thereof, the examples disclosed herein enable each entity of operating in connection with the ECIS to originate and/or modify one or more clinical workflows without relying on the provider of the ECIS to do so on behalf of the entity.", "In other words, although a healthcare entity is part of the ECIS and exchanges data with and via the ECIS, that entity can independently create and/or manage its clinical workflows using the examples disclosed herein.", "Furthermore, the examples disclosed herein enable entities of the ECIS to deploy or initiate the customized workflows without having to reboot or significantly interrupt the ECIS and/or the other components, workflows, etc., thereof.", "The example methods, apparatus, systems, and/or articles of manufacture disclosed herein and the advantages and/or benefits thereof are described in greater detail below in connection with the figures.", "FIG.", "1 is a block diagram of an example healthcare environment 100 in which the example methods, apparatus, systems, and/or articles of manufacture disclosed herein for clinical content-based healthcare may be implemented.", "The example healthcare environment 100 of FIG.", "1 includes a first hospital 102 having a plurality of entities operating within and/or in association with the first hospital 102.In the illustrated example, the entities of the first hospital 102 include an oncology department 104, a cardiology department 106, an emergency room system 108, a picture archiving and communication system (PACS) 110, a radiology information system (RIS) 112, and a laboratory information system (LIS) 114.The oncology department 104 includes cancer-related healthcare practitioners, staff and the devices or systems that support oncology practices and treatments.", "Similarly, the cardiology department 106 includes cardiology-related healthcare practitioners, staff and the devices and/or systems that support cardiology practices and treatments.", "Notably, the example oncology department 104 of FIG.", "1 has specifically designed clinical workflows to be executed in response to certain events and/or according to a schedule.", "At the same time, the example cardiology department 106 of FIG.", "1 has specifically designed clinical workflows to be executed in response to certain events and/or according to a schedule that differ from the clinical workflows of the example oncology department 104 of FIG.", "1.For example, the oncology department 104 may execute a first set of actions in response to receiving a Healthcare Level 7 (HL7) admission-discharge-transfer (ADT) message, while the cardiology department 106 executes a second set of actions different from the first set of actions in response to receiving a HL7 ADT message.", "Such differences may also exist between the emergency room 108, the PACS 110, the RIS 112 and/or the accounting services 114.Briefly, the emergency room system 108 manages information related to the emergency care of patients presenting at an emergency room of the hospital 102, such as admission information, observations from emergency examinations of patients, treatments provided in the emergency room setting, etc.", "The PACS 110 stores medical images (e.g., x-rays, scans, three-dimensional renderings, etc.)", "as, for example, digital images in a database or registry.", "Images are stored in the PACS 110 by healthcare practitioners (e.g., imaging technicians, physicians, radiologists) after a medical imaging of a patient and/or are automatically transmitted from medical imaging devices to the PACS 110 for storage.", "The RIS 112 stores data related to radiology practices such as, for example, radiology reports, messages, warnings, alerts, patient scheduling information, patient demographic data, patient tracking information, and/or physician and patient status monitors, as well as enables exam order entry (e.g., ordering an x-ray of a patient) and image and film tracking (e.g., tracking identities of one or more people that have checked out a film).", "The lab information system 114 stores clinical information such as lab results, test scheduling information, corresponding practitioner(s), and/or other information related to the operation(s) of one or more labs at the corresponding healthcare facility.", "While example types of information are described above as being stored in certain elements of the hospital 102, different types of healthcare data may be stored in one or more of the entities 104-114, as the entities 104-114 and the information listed above is included herein as non-limiting examples.", "Further, the information stored in entities 104-114 may overlap and/or be combined into one or more of the entities 104-114.Each of the example entities 104-114 of FIG.", "1 interacts with an electronic medical record (EMR) system 116.Generally, the EMR 116 stores electronic copies of healthcare records associated with, for example, the hospital 102 and the entities 104-114 thereof The example healthcare environment 100 of FIG.", "1 also includes an outpatient clinic 118 as an example of another healthcare enterprise.", "The example outpatient clinic 118 of FIG.", "1 includes a lab information system 120 and a PACS 122 that operate similarly to the corresponding entities of the example hospital 102.The lab information system 120 and the PACS 122 of the example outpatient clinic 118 operate according to specifically designed clinical workflows that differ between each other and the clinical workflows of the entities 104-114 of the hospital 102.Thus, differences in clinical workflows can exist between the entities of a healthcare enterprise and between healthcare enterprises in general.", "In the illustrated example of FIG.", "1, the hospital 102 and the outpatient clinic 118 are in communication with an ECIS 124 via a network 126, which may be implemented by, for example, a wireless or wired Wide Area Network (WAN) such as a private network or the Internet, an intranet, a virtual private network, a wired or wireless Local Area Network, etc.", "More generally, any of the coupling(s) described herein may be via a network.", "Additionally or alternatively, the example hospital 102 and/or the example outpatient clinic 118 are in communication with the example ECIS 124 via direct or dedicated transmission mediums 128 and 130.Generally, the ECIS 124 supports healthcare information processing implemented by systems, devices, applications, etc.", "of healthcare enterprises, such as the hospital 102 and the outpatient clinic 118.The ECIS 124 is capable of processing healthcare messages from different entities of healthcare enterprises (e.g., the entities 104-114 of the hospital 102) that may generate, process and/or transmit the healthcare messages differently and/or using different formats, protocols, policies, terminology, etc.", "when generating, processing, and/or transmitting the healthcare messages.", "Moreover, the example ECIS 124 of FIG.", "1 supports healthcare practitioners in decision making processes by aggregating healthcare information across disparate enterprises and/or entities thereof and referencing collection(s) of data to automatically generate suggestive and/or definitive data for communication to one or more healthcare practitioners related to the aggregated healthcare information.", "Certain examples provide a library of standardized clinical content and proven best practices.", "Over time, this “library” of content may expand as healthcare organizations add to their own content modules.", "Because the content is standardized it can be shared and leveraged among organizations using the library and associated clinical knowledge platform.", "The library and platform help enable organizations to share best practice content.", "Thus, certain examples provide a clinical knowledge platform that enables healthcare delivery organizations to improve performance against their quality targets.", "In certain examples, a quality dashboard application enables creation of one or more dashboards based on the data/content most relevant to an organization at a given period of time.", "A clinical knowledge platform brings together real-time patient data from existing IT systems within an organization and allows for the comparison of this data against evidence-based best practices.", "The example quality dashboard application leverages the platform to enable personalized “Quality Dashboards” to be created for specific sets of patients, based on condition, role, and/or other criteria.", "Variations from desired practice will be highlighted on each dashboard, enabling care providers to ensure better clinical outcomes and enrich patient care.", "In this example, the clinical knowledge platform aggregates data from an organization's existing IT solutions.", "These can be solutions from the same and/or different manufacturer and/or provider.", "For example, as long as there is an HL7 or Web Services feed, the clinical knowledge platform can utilize the data from an existing solution.", "The existing IT solution(s) will continue to operate as they always have, and an organization can continue to use these solutions separate from the clinical knowledge platform if they so desire.", "However, the clinical knowledge platform and associated application(s) and/or workflow(s) can help to put organizations in greater control of their data by aggregating as much data from disparate IT solutions as possible.", "FIG.", "2 illustrates an example clinical knowledge system 200 providing an aggregation 210 of data from multiple sources.", "Aggregated data may include, for example, medication orders, radiology reports, microbiology, admit/discharge/transfer (ADT) message, lab results, specific observations, electronic medical record (EMR) data, etc.", "As the different data sources are pulled into a central data repository, content standardization occurs.", "It is this “standardization” that enables content from different IT sources to be used together.", "For example, as shown in FIG.", "2, an interface 220 provides terminology mapping and standardization to the aggregated data.", "After the content is standardized, clinical decision support mechanisms can be tied to the content (as illustrated, for example, by the clinical decision support 230 of the system 200 of FIG.", "2).", "The data and associated clinical decision support are then stored in a clinical data repository (CDR), such as CDR 240 of the example system 200.By combining the aggregated and standardized data with clinical decision support rules and alerts, the clinical knowledge platform may provide end-users with an understanding of important elements to which they should pay attention (and take action on) within the larger set of data they are considering when caring for a patient.", "Combined data and clinical decision support mechanisms create valuable content that, when arranged properly, may be used to improve the quality of care provided.", "Organizations can elect to use the application(s) that are provided as a part of the example clinical knowledge platform and/or may choose to build their own clinical application(s) on the platform.", "The open architecture nature of the platform empowers organizations to build their own vision, rather than base their vision on the static/hard coded nature of traditional IT solutions.", "In certain examples, “Quality Dashboards” created via an example application display data via columns and rows in addition to individual patient “inspector” views.", "For example, the system 200 shown in FIG.", "2 provides one or quality dashboards 250 to be created and personalized by an end user.", "The flexible nature of this dashboard application empowers organizations to create dashboards of the aggregated data based on their needs at a given period of time.", "The organization may determine what data elements they would like to include on each dashboard and, without significant IT resources, create a dashboard that reflects their vision.", "In addition, organizations can determine where on the dashboard they would like the information to be displayed and further adjust the view of the content via features such as “bolding” font, etc.", "When data is added to each dashboard, clinical decision support mechanisms attached to this data are displayed on the dashboard as well.", "For example, content related to treating a patient based on a particular use case may be included on a quality dashboard, along with alerts and notifications to indicate to end-users when desired outcomes are varying from defined clinical standards.", "Thus, organizations can create dashboards based on their own idea of “best practice” care for a given disease state.", "In certain examples, since combined content and best practices have been standardized, content from one organization using the clinical knowledge platform may be easily shared with other organizations utilizing the platform.", "In addition, because the content within platform-related applications is standardized in the same manner, upgrades/updates to the example platform can occur efficiently across organizations.", "That represents a dramatic change from prior IT solutions which require unique IT upgrades because they are usually uniquely customized to each organization in which they are installed.", "Generally, content is information and experience that may provide value for an audience.", "Any medium, such as the Internet, television, and audio CDs, may deliver content as value-adding components.", "To analogize to consumer media to illustrate an example relationship, content represents the deliverable, such as a DVD movie, as opposed to the delivery mechanism, a DVD player.", "As long as content conforms to the media standard, any compatible device can play it.", "Content, as used herein, is the externalization or parameterization of “the instructions” that tell applications how to work.", "For example, content is a collection of externalized information that tells software, in conjunction with data, how to behave.", "In certain examples, a clinical knowledge platform takes in and executes content against data to render applications visually and behaviorally.", "Content includes data read and interpreted by a program to define or modify presentation, behavior, and/or semantics of the program and/or of application data consumed by the program, for example.", "Content includes documents presented to a client by a program without modification, for example.", "Content may be created, stored, deployed, and/or retrieved independently of the creation and deployment of the program(s) consuming the data, for example.", "Content may be versionable to capture desired variation in program behavior and/or semantics, for example.", "Classes of content may include configuration content, preferences content, reference content, application content, etc.", "Content types may combine behaviors of two or more classes, for example.", "Software vendors take many different approaches to customization.", "At one extreme, some vendors write different software for each customer or allow customers to write software.", "At the other extreme, a vendor has the same software for each customer, and all customization occurs through creating or modifying content.", "In certain examples, the same software may be used for each customer, and customization is handled through content.", "In healthcare, new laboratory tests, medications, and even diseases are constantly being discovered and introduced.", "Structuring this as content, where underlying software does not need to change, helps accommodate and use updated information.", "In certain examples, many different content types, such as form definitions, data models, database schema, etc., are accommodated.", "In certain examples, each content type may be used differently and involve a distinct authoring tool.", "Thus, in certain examples, content may refer to “a collection of the content instances for all content types,” also called a content repository, knowledge repository, or knowledge assets.", "For example, a content instance is a specific member of a content type, such as a heart rate data model.", "In certain examples, each content type is associated with a generic, extensible structure that content instances of the content type follows.", "An example clinical information system can specify content in an abstract way that does not presuppose a particular software implementation, for example.", "That is, another system, such as GE's Centricity® Enterprise, may consume content from a knowledge repository, apply a different set of software, and achieve the same behaviors.", "Additionally, an abstract content definition can more easily transition to a new system.", "If one can extract content from a legacy system, a knowledge repository may be able to import and reuse it.", "Such a capability helps reduce a large barrier to change for potential customers.", "Content can change with time.", "In an example, a current knowledge repository can handle any “old” data entered into a system under the auspices of an older knowledge repository.", "Occasionally, a question may arise where someone could ask, “What did Dr. Smith see at some past time?” Under these circumstances, a current definition of a particular display may not correctly reflect the situation at the time.", "An example CIS, unlike other systems, can bring back the old form for visualizing the data since all knowledge assets are versioned and retained.", "Content may need to vary for different circumstances.", "For example, an MPV may differ between emergency department (ED) and labor and delivery settings.", "Each MPV has rows and columns of data specific to its setting.", "Context refers to being aware of and reacting distinctively to a location and other situational differences.", "For example, interpretation of a patient's low temperature can vary based on location.", "If it occurs in the recovery room after cardiopulmonary bypass with deliberate patient cooling, it means one thing.", "If the patient is in the ED after breaking through ice into a lake, it means something completely different.", "Context may vary based on user location, patient location, user role, and/or various other factors.", "In certain examples, content may be applied based on context.", "Globalization is a process of adapting software so that it has no language references, before embedding capabilities to make it suitable for particular languages, regions, or countries.", "Having globalized it, a CIS may then translate it to other languages and cultures, called localization.", "Globalizing a software product involves creating content separate from the software.", "For example, embedded text (e.g., user messages), sort orders, radix characters, units of measure, data formats, currency, etc., may be removed and parameterized.", "References to languages, character sets, and fonts may also be removed, for example.", "In certain examples, while display representations may be local, terminology concepts are applied universally, making a rule, calculation, or other content based on one or more terminology concepts useable worldwide without modification.", "For example, FIG.", "3 illustrates an example interdependence of content types.", "As shown in the example of FIG.", "3, content is a set of interdependent building blocks.", "Content may be thought of as a hierarchy, with terminology 310 (e.g., names of lab tests) as a lowest level.", "Terminology 310 may be common and coded across a customer base.", "Clinical element models (CEMs) 320 govern structure and content of objects stored in a database and used by applications.", "A formlet 330 provides a way to display a particular content item (e.g., a way to display a particular lab result).", "A form definition 340 provides an application or view (e.g., a dashboard) of a collection of formlets (e.g., a multi-patient view (MPV) showing one or more lab results and/or other information).", "For example, if a particular MPV definition is moved from one customer to another, the MPV definition along with other content items on which the form definition depends are imported into the new customer's knowledge repository.", "Content items may include appropriate formlets, CEMs, and terminology, for example.", "In certain examples, a detailed clinical model defines, at a granular level, the structure and content of a data element.", "For example, the detailed Clinical Model for “Heart Rate Measurement” dictates the data type of a heart rate measurement, and the valid physiologic range of a heart rate.", "It says that a “body location” is valid qualifying information about a heart rate measurement, but a “color” is not.", "It further decrees that the valid values for “body location” are terminology codes found in the “heart rate body location” value set.", "Moreover, it prescribes that a “resting heart rate” is an instance of “Heart Rate Measurement” where the value of “temporal context” is “resting”, where “resting” is also a coded value.", "A detailed clinical model pulls the information together into a single, explicit, and computable form.", "The detailed clinical models or clinical element models (CEMs) govern the content and structure of all data objects stored in an example clinical database and used by applications, for example.", "In addition, CEMs are extensible, such that content authors may add new CEMs or attributes to existing CEMs without requiring major changes to database structures or software, for example.", "In certain examples, shared or portable content is, in effect, “plug 'n play”.", "System administrators can add it (e.g., plug it into) to a system without any software changes, and the content behaves in the intended way and does not cause errors.", "The size or scope of shared content can range from a single term to an entire knowledge repository, for example.", "Shared content fundamentally changes an implementation paradigm and reduces a total system cost of ownership, for example.", "Customers can change shared content.", "Customers can improve it or make it more suitable for their institutions.", "When customers do this, they leave the original definition intact, but clone it and keep their changed version in their “local” space, for example.", "As described above, classes of content may include configuration content, preferences content, reference content, application content, etc.", "Configuration content is content that is modified infrequently and is concerned primarily with system behavior, for example.", "Examples of configuration content may include internet protocol (IP) address and port of clinical knowledge database, identifiers of terminals in systems, security access privileges, configuration files, etc.", "Configuration content may affect program semantics, for example.", "Configuration content is generally modified by system administrators and is often stored in the file system, for example.", "Preference content is modified frequently and is concerned primarily with variation between users.", "Examples of preference content include display colors and fonts, default search parameters, screen layout, etc.", "Preference content rarely affects program semantics and is most commonly modified by individual users.", "While modified by users, the system generally distributes initial or default preference content.", "In certain examples, distributed or default preference content behaves very similar to application content before modification by a user.", "Preference content may be context sensitive, transformed at deployment, etc.", "Preference content may include vocabulary concepts and pick-lists that are resolved when loading and retrieving just like other content types.", "Reference content is documents that are presented without modification as part of the application.", "Reference content is often stored in formats that are opaque to a program (e.g., as a PDF, a Microsoft Word™ document, etc.).", "Reference content is generally not specific to or customized for a specific patient (e.g., instruction sheets, information sheets, policies and procedures, etc.).", "Reference content may be independent of program semantics and behavior.", "Reference content may be authored independently of a program.", "While not an element of a content drive system per se, reference content is often managed as content by a clinical knowledge system.", "Once reference content is modified for presentation to a specific user, the content starts behaving much more like patient data/documents.", "Reference content with the structure to enable modification starts behaving much more like application content.", "Application content may be modified frequently or infrequently depending on use.", "Application content may be concerned primarily with application behavior and semantics.", "Applicant content may be generally specific to an application domain.", "Examples may include a flow sheet template, clinical element models, terminology, document templates that are modified and stored as patient data (e.g., hot text), etc.", "Terminology is application content but has behaviors distinct from other application content types and is managed (largely) independently of other application content, for example.", "Application data often affects program semantics and behavior.", "Application content may be authored at multiple levels in an organization or external to the organization, for example.", "Application content may be implemented as a custom markup language, for example.", "Application content may be implemented as a domain specific language (DSL), for example.", "For example, data queries may be implemented using a frame definition language (FDL).", "Clinical element models may be implemented using a constraint definition language (CDL).", "Application content may be directly authored or imported as data into a content store (e.g., concepts in a vocabulary server), for example.", "In certain examples, while patient data is transactional and often includes discrete data elements, application content is often structured, complex objects and often has associated metadata.", "In certain examples, metadata is data used to manage content, such as content identifier, version, name of author, access privilege, encryption certificate, etc.", "Metadata is not treated as content, for example.", "While patient data is owned by a patient and is part of a legal record, application content is not owned by a patient and is not part of a legal record.", "Application content may be published (e.g., is not transactional) and managed using a lifecycle.", "Certain examples provide content-driven systems and processes that rely primarily on content to determine application behavior.", "An example system includes a reference platform that consumes, interprets, and/or executes content while remaining application neutral.", "An example system uses content that remains independent of an implementation of the reference platform to allow independent evolution of the platform and the application.", "FIG.", "4 illustrates an example hierarchy 400 of content, associated data models, and terminology.", "In certain examples, once one chooses content based data models, content-based queries and data management are also selected.", "Content based applications are also chosen.", "An integral terminology basis includes semantics of data defined in terminology content, for example.", "As shown in the example of FIG.", "4, application definition content 410 (e.g., MPV templates, form(let) definitions, interface mappings, and/or document templates, etc.)", "relies on data management content (e.g., frames) 420 (e.g., data query definitions, data update definitions, and/or data transformations, etc.).", "The data management content 420 leverages data models (e.g., CEMs) 430, such as clinical data organization (e.g., structure) and/or coded clinical data, etc.", "The data models 430 are constructed based on a terminology 440 including clinical concepts and relationships between concepts, for example.", "In certain examples, context refers to metadata attributes and/or labels that differentiate variations of a content item.", "For example, each variant of content item may be referred to as a context variant.", "Each variation of a content item has a specific set of context attributes (e.g., language, location, role, etc.).", "An algorithm or heuristic may select a desired variant when retrieving based on a current user's “context.” This process may be referred to as context resolution.", "Searching refers to examining the content item and/or associated metadata for matches independent of context.", "Searching can include context attributes to filter for specific context variants in the search.", "The difference is that a specific variant is not selected algorithmically or heuristically by the content system when searching.", "Using the “user” as a context attribute is one way to associate a content item with a specific user; similarly provider as a context variable could be used to associate an item with a group of users.", "Resolving context generally requires some heuristic to resolve ambiguity or conflicts among context variants (e.g., weighting or priority schemes, default rules, etc.).", "This leads to some ambiguity since changing/adding a context variant or changing the weights of context attribute may change the context resolution on another item in not always obvious ways (at least to a user).", "In certain examples, a content item includes: 1.A root content item represented by a universally unique identifier (UUID).", "The root content item includes metadata only; no actual content is stored.", "2.One or more context variants that represent variations of an implementation of the content item in different client contexts occur as children of the root content item.", "3.Context variants may form trees of increasing context specialization (e.g., a context variant may have child variants).", "4.Each context variant has a unique UUID as well as a relation to the root content item.", "5.Each context variant maintains versions of that variant as changes are applied to the variant.", "As shown in the example of FIG.", "5, a root content item 510 has one or more content variants 520-522.Each content variant 520-522 may be associated with one or more context variants 530-531.FIG.", "6 provides an example multi-patient view (MPV) 600 made up of a plurality of formlets 610-614 and a frameset 640.Each formlet 610-614 corresponds to a concept 620-624 and a model 630-634.The frameset 640 is also associated with each model 630-634, and each model 630-634 is associated with a concept 650-654, for example.", "In certain examples, content may be stored in multiple content stores.", "For example, content may be stored in an ECIS database, an XDS repository, a third-party system, etc.", "Content documents in storage may be identified by a URI that specifies the content store and the key of that item in that content store.", "A content directory including the content metadata may be searched to obtain the URI for retrieval of the content item.", "A content type manager may specialize the search, storage, and/or retrieval of items of that content type, for example.", "A content item in the content directory is keyed via a UUID for the item.", "That UUID is not necessarily part of the uniform resource indicator (URI) that defines the storage location.", "In certain examples, content items may be organized as a content type.", "A content type is a set of content items that are defined and managed using common definitions and methodologies (e.g., terminology, clinical element models, frameset definitions, etc.).", "Content types may have different behaviors, states, lifecycles, etc.", "Each content type may be managed by a specific content type manager, which is treated as a plug-in to a clinical knowledge platform and/or associated clinical information system, for example.", "Content types may be added by creating a new content type manager, for example.", "Content type managers may interact with a content management framework by implementing a set of event handlers (e.g., package, deploy, retrieve, etc.).", "“Generic” content types (e.g., content types with no special behavior) may use a default content type manager.", "An owner of a content type is responsible for implementing an associated content type manager, for example.", "In certain examples, during authoring (that is, before deployment), dependencies exist between content items.", "At runtime (that is, after deployment), dependencies exist between deployed forms of context variants.", "Dependents that exist during authoring may or may not continue after deployment.", "For example, terminology description and pick-list resolution are translations during loading and retrieving, not dependencies per se.", "In certain examples, at runtime, dependencies are between deployed forms of context variants, not the context variants themselves.", "The deployed form of a context variant is a “content frame”.", "At deployment time, it may be necessary to guarantee that the packages (e.g., terminology) that a package depends on are also deployed.", "Terminology dependencies may be inferred from terminology relationships and mappings and do not need to be explicitly tracked.", "In certain examples, a content based system provides a capability to distribute content and content updates to external instances (e.g., test systems, quality assurance systems, customer installations, content patches (e.g., SPRS), etc.).", "An example distribution system provides a capability to distribute content items and associated dependent content items and/or insure that those content items already exist in the target system.", "For example, an FDL content item must have access to the clinical element types it references in order to process a frame query.", "The example distribution system may also facilitate an undo or reversal of installed content items that generate issues.", "Content may be distributed as large sets of items (e.g., during installation) and/or as individual items (e.g., bug fixes), for example.", "FIG.", "7 illustrates an example content management process 700.The example process 700 includes authoring 710, packaging 720, exporting 730, importing 740, deploying 750, loading 760, and retrieving 770.Authoring 710 includes a process of creating and/or modifying a content item.", "Authoring may be done by an author composing content directly using an editor (e.g., CDL, FLD, etc.", "), for example.", "Authoring may be done using tools (e.g., editor(s), etc.)", "that are specific to a content-type (e.g., terminology), for example.", "Authoring may be done by tools within the application(s) consuming a content type (e.g., MPV, forms, etc.", "), for example.", "Authoring may be done by applications generating a content item (e.g., MPV generating FDL), for example.", "In certain examples, there is no single authoring environment for content; rather, there is a family of authoring tools that is often content type specific.", "Packaging 720 includes combining all content items and (applicable) context variants within a transitive closure of dependency graphs of one or more content items into a package, for example.", "Packages may include multiple independent top level content items, for example.", "Packages may have dependency(-ies) on other package(s).", "For example, a package containing a frameset content item may dependent on a separate terminology package as a prerequisite to deployment.", "Packages may very frequently contain multiple independent, top level items each with its associated dependency graph.", "A package may not include all context variants of an item.", "For example, packaging may filter based on context to form a package.", "Packaging events may include an event to allow a content type manager to specify dependencies of an item being packaged.", "Packages may have dependencies on content types other than content packages.", "For example, a terminology package is a different content type than a content package.", "Content items within a package may not have explicit dependencies on terminology concepts.", "Rather, the package has dependencies on the appropriate terminology packages.", "In certain examples, packages are used as a distribution mechanism.", "Packages may be deployed before items in the package are available to a runtime system, for example.", "Packages themselves may be treated as content items.", "Thus, packages can themselves be packaged (e.g., packages of packages), and packages may be dependent on other packages.", "In certain examples, packages may belong a namespace or domain.", "For example, packages may only include items from a single namespace.", "Packages may have dependencies on packages in another namespace, for example.", "Package(s) may be exported 730 from one system and imported 740 into another.", "Exported packages may be used to distribute content, for example.", "System management tool(s) may be provided to create, export, import, and deploy content packages, for example.", "Deploying 750 includes making content items included within a package available to a running system.", "A content item may be transforming during deployment, for example.", "For example, constraint definition language (CDL) models may be compiled and may create multiple type objects each with an associated schema.", "As shown in the deployment example of FIG.", "8, a plurality of models 810 in a content package 815 are deployed 820 to create a content frame 830 including plurality of type objects 835 with associated XML schema.", "In certain examples, each top level content item in a package being deployed is deployed independently.", "A deployed content item is logically (and often physically) a different object than the content item being deployed.", "For example, a deployed content item has independent state and lifecycle.", "Multiple content items may be created during deployment, for example.", "For example, deploying a CDL model may generate a CE type object and an XML schema.", "In certain examples, a source content item may not exist in the runtime system.", "For example, the source CDL models are not employed, and the generated CE type object is deployed.", "Deployment of a package may be done manually and/or implicitly by an authoring tool, for example.", "For example, system administrators may wish to explicitly control deployment of data models but MPVs authored by a user may be implicitly and immediately deployed.", "In certain examples, each deployed content item is bundled with all of the content items that are used to execute and/or consume the item.", "The bundle is referred to as a content frame 830.A content frame 830 is analogous to an archive file manifest.", "It may not (necessarily) contain the actual content items.", "The content frame 830 may not include all of the items generated during deployment.", "For example, the CDL schemas may not be part of the frame.", "A content frame 830 is also analogous to a context variant.", "The frame has its own unique identifier but may be retrieved using the identifier of the root content item the frame is based upon in the same way that context variants are retrieved.", "Deployment events may include an event to allow the content type manager to specify dependencies of the deployed item(s) within the content frame, for example.", "In certain examples, context resolution refers to conditioning selection, composition, and/or behavior of a content item based on a context of a user.", "Context resolution may occur at one or more levels.", "For example, context resolution may occur on selection of the content item(s) that a content item being deployed is dependent upon based on context.", "Such resolution occurs during deployment, and content frames are context specific with dependencies resolved.", "Context resolution may occur on selection of a content frame based on context when the content frame is retrieved by an application, for example.", "Context resolution may occur on translation of a content item based on context when loading and/or retrieving a content frame, for example.", "For example, context resolution may occur upon retrieval of terminology concept designations and/or retrieval and population of pick-lists.", "Translation may be performed by the content type manager during loading and/or retrieval, for example.", "A template tool such as Apache Velocity may be used to implement the translation.", "The sensitivity of a content item to changes in the terminology server is a function of when the translation is applied e.g., during deployment, loading, or retrieval), for example.", "During deployment, context may be used algorithmically/heuristically to select dependent items and/or the deployment tool may specify the required dependent items.", "In general, context resolution is done heuristically (e.g., scoring and weighting schemes) because of the difficulty in determining an unambiguous algorithm to resolve conflicts.", "The content type manager may provide its own mechanism for context resolution, for example.", "In deployment 750, a content item may be a part of multiple content frames.", "For example, multiple copies of a content item may be loaded by an application if it loads multiple content frames containing the item.", "Applications may search for and retrieve content frames.", "For example, content management may load and cache content frames.", "In certain examples, authoring tools may retrieve content items directly.", "Running applications may retrieve content frames during execution, for example.", "Context may be resolved while constructing a content frame.", "That is, selection of context variants on which the deployed content item is dependent is done during deployment, for example.", "Content frames may thus be context specific.", "During load and retrieve, context may be used to select a content frame, not content items contained in the frame, for example.", "A content frame may itself be considered a content item.", "Thus, the content frame may be versioned, have associated metadata, etc.", "Since a content frame is a content item, packages of frames may be constructed and distributed content frames without the associated source content items, for example.", "In certain examples, content frames may contain content frames, allowing courser grained deploy and undeploy operations.", "In certain examples, optimizations to frame loading (e.g., loading a single copy of a common content item) may be done, if desired, using techniques such as reference counting, etc.", "In certain examples, content frames are related to a deployed root content item in a fashion analogous to the relationship between context variants and the content item.", "For example, a content frame is identified by the same UUID as the root content item in the frame and shares the same directory metadata.", "Each content frame may have its own unique identifier that may be used as a reference.", "Each content frame may be context specific and may have multiple versions.", "In certain examples, only deployed content items have associated content frames.", "Because of this relationship, content frames may be treated in a directory as properties of a content item along with context variants, for example.", "In certain examples, content may be undeployed.", "An undeploy is a process of a making a (deployed) content frame unavailable to a running instance, for example.", "However, data instances stored in a CDR may be dependent on the content frames used to create the data instances (e.g., clinical element (CE) types).", "As a result, a content frame, once deployed, may not be physically deleted from the clinical content system without compromising referential integrity, for example.", "Undeploy, then, may make a content frame invisible to subsequent searches and context selection.", "Through undeploy, a previous version of a content frame may then be once again visible to search and context selection, for example.", "In certain examples, an undeployed content item may still be directly retrieved using the UUID for the content frame.", "In certain examples, content item translation refers to modifying a content item during loading and/or retrieval to make the content item responsive to changes in content items on which it is dependent without redeploying the content item.", "For example, terminology designations and pick-lists may change independently of the deployment of the content item.", "Content item translation may be a responsibility of a content type manager responsible for a content item.", "For example, translations that make sense for one content type may not make sense for another content type.", "Content item translation may be context specific, for example.", "Content item translations may be performed by inserting custom macros in a content item (e.g., at authoring time) and applying a template tool to execute the macro and perform the translation with the item is retrieved.", "Content item translations may be fine-grained.", "For example, they do not change the structure of the content item but replace elements (e.g., labels, lists of labels, etc.)", "within the item.", "Course grained modification of content frames (such as re-resolving content items that the content item being retrieved is dependent upon at retrieval time) may be undesirable because they can lead to unpredictable changes to application appearance or behavior.", "Hence, these kinds of modification are restricted to occurring at deployment time.", "In certain examples, common tools may be used to perform translation of content items represented in XML or HTML.", "Apache's Velocity is used here as an example only.", "Dependencies for items that depend on translations may be managed by maintaining a content frame dependency on a content frame containing the items to be translated (e.g., a terminology content frame) rather than by maintaining specific dependencies, for example.", "Loading 760 is a process of retrieving a content frame containing deployed content item(s) from storage and making the frame available for use by running application(s).", "Content items in a content frame may be translated during loading.", "For example, terminology designations may be resolved and/or pick-lists retrieved.", "A content frame may be cached after loading.", "Content items contained within a content frame may be loaded as a single operation, for example.", "In certain examples, the choice of doing translation at retrieval time or load time is up to the content type manager.", "Translating at load time means that the cost of translation is amortized over multiple uses of the item; translating at retrieve time means that the item is more sensitive to context variation and changes in resolved content.", "A selection of translation time may be content type specific, for example.", "Retrieving 770 includes fetching a loaded content frame by a consuming application.", "Content items within the content package may be translated during retrieval (e.g., resolving terminology designations, retrieving pick-lists, etc.).", "A loaded content package may be retrieved multiple times by different clients, for example.", "An application may choose to reuse (e.g., cache) a retrieved content package at its discretion.", "Content items within a content frame may be loaded as a single operation, for example.", "In certain examples, since a content item may be present in different content packages, different instances of an item may be translated using different context.", "For example, an application may show a content item in two different languages concurrently for comparison.", "A choice of doing translation at retrieval time or load time may be made by the content type manager.", "Translating at load time means that the cost of translation is amortized over multiple uses of the item.", "Translating at retrieve time means that the item is more sensitive to context variation and changes in resolved content.", "A selection of translation time may be content type specific, for example.", "In certain examples, content may be divided based on namespace.", "A namespace is a partition of content items in a system where each partition is owned and managed independently of other partitions.", "FIG.", "9 provides an example of namespaces A, B, and C including various content items (CIs).", "Namespaces may be motivated by various factors.", "For example, content items in one namespace may be protected from modification by another party (for example, a customer modifying GE distributed and owned content).", "Applying maintenance (e.g., updates, bug fixes, etc.)", "becomes difficult, if not impossible, if a customer can modify GE distributed content (e.g., customer modified content may potentially be broken when replaced with an update).", "Alternatively or additionally, for example, customers may be allowed to add and extend distributed content in safe ways while enforcing governance restrictions on such modification (e.g., models may not be modified or extended, but MPVs may).", "While some of these restrictions may be enforced by a security system, customers often set security policy, so another mechanism may be used to enforce such restrictions.", "Additionally, some rules such as inheritance restrictions may not be adequately managed via security policy.", "In certain examples, a simplified namespace model provides that each content item in a system may be searched for using a single namespace precedence order.", "It is possible that different content types may involve different search precedence (e.g., a search path to resolve data models may not be the same as a search path to resolve forms or reference content).", "Extensions to the model can be made based on circumstances, for example.", "In certain examples, namespaces may be “owned” by a provider, a customer institution, a department, etc.", "Such ownership separates provider content from customer content, for example.", "Multi-tenancy and digital rights management may be facilitated through the use of namespaces, for example.", "In certain examples, only the owner of a namespace may create or modify content items within the namespace.", "An owner may own multiple namespaces, for example.", "A clinical knowledge platform and/or associated enterprise clinical information system may serve as an owner of a “root” namespace (and possible others), for example.", "Each customer installation may be an owner of at least one namespace for that customer, for example.", "In certain examples, an “owner property” on a content item used as a context attribute is also presented in some contexts as equivalent to a namespace.", "However, in context resolution, using an owner property there may be no inherent precedence.", "For example, given a concept with designations potentially owned by A, B, and C, an application asks for the designation owned by A but that designation does not exist.", "Does the system return designation B or designation C?", "In general, property precedence in context resolution involves a heuristic to resolve (e.g., weighting and scoring schemes).", "Additionally, there may be necessary relationships between content items in namespaces.", "For example, specialization via inheritance, overriding content items in one namespace with the same item in another, copying an item from one namespace to another (e.g., is it legal to do the copy?", "), etc.", "These behaviors may or may not be able to be implemented using an owner property (alone) in the general case.", "Additionally, “owner” may be used in at least two different senses: first, as an intellectual property/digital rights management (IP/DRM) concept where it designates actual ownership (e.g., a package by “owner” is a practical application of this concept—package everything that is owned by an owner); second, as an attribute used to select a desired/appropriate context variant when retrieving a content item.", "This second usage is more directly analogous to namespaces with the caveats above.", "In certain examples, a difference between an owner context attribute and a namespace is that namespaces are known to and defined by a system rather than defined independently for each content item in content (e.g., owners are generally terminology content).", "The system can establish precedence, maintain persistent/immutable relationships between items in different namespaces without expectation that the relationships will change, for example.", "That is, “namespaces” may be part of a reference implementation; owners are content defined and hence may be interpreted by the reference implementation, for example.", "In certain examples, namespaces have “precedence” when searching retrieving, etc.", "For example, as shown in FIG.", "9, a highest precedence namespace C is first searched for a content item, then a second highest (e.g., namespace B), etc.", "Precedence may be established when configuring the system or defining the name spaces, for example.", "Precedence may be overridden when deploying a package.", "In certain examples, relationships may exist between content items in one namespace and content items in a lower precedence namespace.", "In certain examples, changing namespace precedence may change the nature of a relationship.", "In certain examples, a new content item may be created in a higher precedence namespace by copying an item in a lower precedence namespace.", "For example, an MPV may be copied from base content, modified, and saved as a user-owned MPV.", "A content item may be created in a higher precedence namespace that hides or replaces the same content item in a lower precedence namespace, for example.", "For example, a new version of a formlet that hides the same formlet in base GE Qualibria® content to customize display of that formlet.", "Creating a new content item that specializes (e.g., inherits from) an existing content item may hide or replace a base content item in a lower precedence namespace.", "For example, a new attribute may be added to a patient clinical element model provided by Qualibria by specializing the Qualibria patient model.", "In certain examples, namespace relationships are managed by a content management system.", "If a base content item is modified, a specialized content item may need to be redeployed.", "In certain examples, specialization of a content item in a namespace may be allowed in another namespace but copying the content item may not be allowed.", "State changes in a base content item may involve state changes in a specialized content item (e.g., if the base item is deprecated, the specialized item may also require deprecation), for example.", "In certain examples, digital rights management may prevent a copy of a content item from being created.", "In certain examples, if a content item that was copied to a new namespace is modified, an owner of the target namespace may need to be notified of the change so the copy can be reviewed for changes.", "In certain examples, an owner attribute on a content item may be insufficient to manage namespace relationships.", "Clinical element models (CEMs) are an example of a relationship restriction: copying and hiding a CEM can lead to data inconsistencies while specialization through restriction or extension can be safely done.", "Hiding an MPV on the other hand, is generally a safe operation, for example.", "In certain examples, relationship management/enforcement is a responsibility of a content type manager (CTM), or at least the CTM should be able to specialize system relationship management.", "Namespaces may be used in a variety of stages of a process.", "For example, namespaces may be used during authoring.", "For example, namespaces may be used when resolving context variants, establishing relationships such as copy, copy and hide, etc.", "Namespaces may be used during packaging, for example.", "A package may include content items from a single namespace, for example.", "Context variants, relationships, etc., in other namespaces involve dependencies on packages in those namespaces, for example.", "Namespaces may be used during deployment (e.g., when resolving context variants, when establishing relationships such as inheritance relationships, etc.", "), for example.", "In certain examples, namespaces are not used during load and retrieve at runtime.", "In certain examples, each context variant of a content item has a current “state”.", "For example, a state may include deployable, deployed, loaded, deprecated, etc.", "Each content type has a set of allowable states and a set of allowable state transitions represented as a state machine.", "Content types may have different state machines in an authoring environment than in a runtime environment, for example.", "State machines may be owned by a content type manager since the manager defines a meaning of each state for a content type.", "In certain examples, a state in a runtime system is actually the state of the content frame.", "However, for simplicity, a state of the content frame is assumed to be (and managed as) the state of the root content item.", "A state of content items included via dependency resolution may be irrelevant to the runtime system (e.g., it may be required that the root content item of the content frame be redeployed to bubble up state changes in that item).", "In certain examples, lifecycle management refers to a set of workflows that manage transition of a content item from one state to another.", "Each state in a content type state machine is associated with a distinct workflow that manages the content item when in that state, for example.", "In certain examples, workflows are content items to allow variation across implementations.", "FIG.", "10 depicts an example of a state versus a workflow.", "As shown in the example of FIG.", "10, each state in a content item state machine 1010 has an associated workflow 1020 that controls transition(s) to the next state(s).", "In certain examples, governance refers to a set of policies that manage lifecycles of each content type.", "Governance policies are implemented in state machines and associated workflows of a content type, for example.", "Governance may be an operational function, for example.", "Certain examples provide a content-based clinical information system including a stable reference platform that defines and executes the core capabilities of the system and a set (e.g., one to many) of content classes (e.g., content based languages) that are implemented upon the reference platform and that independently define clinical information functions.", "The content classes are specialized to allow implementation of narrowly defined clinical functions, for example, Defined clinical functions can include data definition, data query, data transformation, data display, data entry, decision support rules, etc., for example.", "In certain examples, clinical applications are created by composing one or more content items (e.g., instances of a content class) from one or more content classes.", "Each content item is authored or created independent from the creation of the reference platform.", "Content items and the reference platform can have independent life-cycles and evolve independently over time, for example.", "Since content classes are independent, support for additional content classes can be added as an update to the reference platform to extend core system capabilities, for example.", "Certain examples provide content and data, along with executable software or code.", "In certain example, content includes data and expressions/instructions concerning data.", "However, neither data nor content is “software” as the term software is traditionally defined.", "In certain examples, content is stored in a content database and is independent of hard-coded libraries.", "Thus, clinicians do not need a new installation of software to change an application, such as a multi-patient view (MPV) dashboard.", "Other dashboard views can include a rapid recovery dashboard, a hospital-acquired infections dashboard, etc.", "Content can be configured by a clinician, technician, and/or other user at a location without the platform provider's intervention.", "Clinicians can author new MPVs on the fly, for example.", "In certain examples, content can be used to facilitate a query for data by a user and/or application.", "FIG.", "11 illustrates an example clinical information system 1100 including a reference platform 1110 and one or more content items 1120 that define clinical functionality (e.g., content-based applications).", "The example content-based clinical information system 100 of FIG.", "11 includes a reference platform 1110 having three major layers 1112, 1114, 1116.In the example system 1100 of FIG.", "11, Reference Platform Services 1112 provide foundation services to implement content class managers and interpreters.", "The reference platform services 1112 are constructed using standard software development techniques and can be modified independent of content items implementing application functionality to enhance available system functionality without impacting the application functionality, for example.", "In the example system 1100 of FIG.", "11, a Content Class Managers layer 1114 implements management services for one or more content classes.", "A content class includes defined (e.g., a narrowly defined) domain specific language that allows clinical personnel to define custom programmatic elements (e.g., content items) that will be used when composing a clinical application (for example, clinical vocabulary concepts, clinical data models, data queries, data transformations, display forms, etc.).", "An example Content Class Manager provides capability(-ies) to author content items of that content class.", "The example content class manager provides capability(-ies) to package those content items for distribution, export and import the content items from and to installations of the clinical information system, and deploy the content items to a running clinical information system (e.g., compile, translate, etc., the content item into an executable form).", "The example content class manager provides capability (-ies) to load the content items into memory while performing context-based translation of the content item (e.g., resolve terminology designations, pick-lists, etc.", "), and to retrieve the content items for execution in an associated content class interpreter.", "While a running clinical application can include content items of different content classes, each content item is independently managed by the content class manager associated with the content item.", "In the example system 1100 of FIG.", "11, a Content Class Interpreter layer 1116 defines one or more interpreters (e.g., programs that consume a content item and execute the instructions defined in the content item) for content items of each content class.", "Since an application is a composition of content items, multiple content class interpreters can participate in the execution of the composed application(s).", "Content class interpreters consume a deployed (e.g., executable) form of the content item(s).", "Optimizations and/or other improvements to performance of a content item interpreter can be implemented in conjunction with a content class manager, for example.", "Content Based Applications are composed of one or more content items that are managed by content class managers and executed by content class interpreters.", "A set of content items of which an application is composed are stored in a content repository and managed as a set of interdependent items.", "Content based applications are independent of the reference platform; that is content based applications can be changed without changes to the reference platform, and the reference platform may be changed without changes to the content based applications (though content based applications may be changed to take advantage of new capabilities in the reference platform), for example.", "Since medical practices vary widely between different institutions (and even within institutions or between patients) and change rapidly as medical practices evolve, prior clinical information systems require extensive customization to be deployed widely.", "Very frequently, this degree of customization can render ongoing maintenance (e.g., new releases, error fixes, etc.)", "difficult or even impossible.", "Additionally, responsiveness to requests for customizations may be unacceptable to the institutions because of the difficulty in creating, testing, distributing, and managing the customizations.", "Two common approaches to these issues may be found in existing products.", "First, the producer of the system tightly controls the software system and controls/restricts the changes that can be made to the system, thereby severely restricting the ability of the software to be customized to specific customer needs.", "Second, the producer of the system may allow extensive customization of the software wherein each implementation becomes essentially a custom system which limits the maintainability of the system.", "Certain examples address these problems by separating the application, where customization generally occurs, from the system itself, where maintenance generally occurs.", "An example clinical information system application is implemented in content, that is, as a set of content items that are created and maintained independently of the system, often by the customers of the system themselves.", "The reference platform (e.g., the system) is maintained, enhanced, tested, and deployed by a vendor.", "Since the application (in content) is independent of the reference platform, the two can evolve largely independent of each other.", "Independent evolution allows a much greater degree of possible customization without reducing the maintainability of the system, for example.", "Rather than basing content on a single general-purpose interpreted language, certain examples implement a content based system as a set of content languages.", "In certain examples, each content language is narrowly focused and specialized to allow independent evolution, optimization, etc.", "In certain examples, by separating applications from a reference implementation, independent evolution of the application and the system can be supported.", "In certain examples, application(s) can be authored by domain specialists rather than by engineering.", "For example, terminology and data can be modeled by informaticists; clinical forms can be designed by clinical teams; etc.", "In certain examples, functionality can be added to the system incrementally by adding new content classes to the system.", "Since content classes are narrowly focused for specific tasks, a risk of over-generalization is reduced or avoided, for example.", "Content classes can be independently evolved and improved/optimized, for example.", "In certain examples, clinical content includes structured knowledge components such as decision support rules, protocols, reports, user preferences (e.g., triage form layout, patient and/or department worklist format, etc.", "), and unstructured knowledge components such as discharge instructions, guidelines, etc.", "Clinical information systems (CIS) that are content-driven provide functionality that improves clinical outcomes by enhancing compliance with institutionally/nationally recognized standards of care and reduce practice variation.", "In certain examples, a new process has been defined to streamline clinical content management from its inception to its consumption by the CIS.", "The example process allows for building of an infrastructure for managing clinical content in a more efficient and more optimal manner.", "Using this clinical content management process, clinical content management is scalable and expressive, for example.", "When a CIS is introduced into a new environment, lack of a standard process interferes with resource planning, effort planning and estimating timelines, for example.", "An example clinical content management infrastructure built around this process can help with the implementation effort by identifying appropriate dependencies, breakdown tasks along with their associated resources, and help align priorities.", "In an example, a small client is interested in going live with a couple of clinical modules (e.g., a discharge module and a billing module).", "As part of these modules, using the example content-driven process, structured and unstructured clinical content can be authored, versioned, packaged, and tracked to ensure compatibility with future updates.", "Building on the example use case, if the client wants to add its own local content, plug-n-play packagers and deployers are provided that are applicable only to these two modules.", "If the client is happy with the two example modules and wants to go live with additional modules, the infrastructure built around the process can scale up to identify potential clinical content interdependencies, help eliminate redundancies, and bridge clinical application versions and clinical content versions, for example.", "In certain examples, the clinical content management infrastructure can be integrated into a software lifecycle to eliminate separate iterations and planning exercises.", "Integration can produce significant savings in planning, effort, and execution time, for example.", "In certain examples, during the content authoring and packaging processes, the infrastructure verifies and validates dependencies and helps ensure content integrity, for example.", "The infrastructure eases the process of versioning at the content and package level.", "In certain examples, future updates can be automatically packaged as patches that can be released internally and/or externally to clients on a pre-determined schedule.", "Patch releases can still maintain content integrity that can be described through a conformance statement, for example.", "In contrast, prior enterprise clinical information systems rely on ad-hoc processes for clinical content management, wherein processes are manually created on the fly by programmers on a case-by-case basis.", "Some significant impediments to the adoption of standards and coded content (e.g., structured/unstructured) in clinical information systems are high costs associated with clinical content authoring.", "In addition, prior techniques resulted in uncertainty in managing dependencies between content types, and uncertainty in creating predictable release cycles.", "Thus, certain examples provide a clinical content management process that is scalable, expressive, and semantically interoperable.", "For example, the process is scalable in that it can support core content as determined by an application's needs in addition to customer/competitor specific content.", "For example, the process allows end users to consume content to support individual preferences at an enterprise level.", "For example, the process provides an infrastructure for clinical entities to create semantically interoperable systems to derive clinical, research and business benefits thereof From a business standpoint, the example process enables modular content packages and pluggable deployment.", "This flexibility allows tailorable content to support different types of clients to augment a “surround and supplement” strategy, where-in a small client with limited budget can go live with only couple of modules/content-deployers, whereas a large enterprise customer might want a whole suite of content management infrastructure.", "Certain examples define processes apriori to help ensure that structured and unstructured clinical content development and management is more predictable, measurable, efficient, and integrated into application lifecycle management.", "Current systems and/or processes for managing clinical content in content-driven systems are fraught with uncertainties such as in version compatibility, quality control, timely packaging and delivery of content, updating knowledge bases, and smart deployment.", "Building a clinical application on an infrastructure as described herein provides significant benefits to a content management process such as making it scalable, expressive, supportive of standard(s), semantically interoperable, and flexible.", "In certain examples, content and infrastructure can be used to map or resolve concept identifiers into human-readable designations using a terminology.", "Typically, when a computer system is designed for an industry or application, the system is designed to meet the needs for the most customers in the industry as possible.", "Sometimes different customers want to use the system in different ways.", "This can be solved by making systems that are configurable.", "There are cases were different individual users or departments want their own configurations or preferences.", "This invention improves the way a system stores and manages these preferences.", "Some industries have adapted the way they do business to fit the computer system purchased.", "A distribution center might change the way it fills orders in order to fit the way the computer software wants it tracked.", "This does not work with clinical information systems.", "Different hospitals vary greatly in how they provide health care and how they use their information systems.", "Different doctors also do things differently.", "It may be simple to train a store clerk the new way to fill orders, but it is difficult to ask a doctor to change the way they do things.", "It is not reasonable for a health network to adapt to its chosen software, so the software needs to adapt to the particular health network, region, hospital, department, and care provider.", "One example of how a clinical information system might be configured is a patient admission screen.", "The software for the clinical information system includes an admission screen for new patients.", "The admission screen includes a form associated with a workflow directing which information to collect and when to collect it.", "The admission screen may also display other information about the patient or hospital to assist the care provider during the admission process.", "While the system includes an admission screen that works well for many hospitals, it will not have everything needed for every situation.", "Different hospital networks may want to change the admission process to be different from the one that is included by default with the software.", "In those cases, they will want to modify the admission process to fit the needs of their network.", "Within the hospital network, there may be a region that needs to modify their admission process.", "Within that region, there may be a hospital that needs to add a step in the admission process specific to that hospital.", "There may even be a care provider who wishes to modify the way the admission form is laid out to fit a user specific need.", "These modifications are based on a context.", "The region, hospital, language, and user all help to define the context for the particular admission process.", "The context is based on a hierarchy where the hospital depends on what regions it is in, and the user depends on what hospital it is in.", "For example, a user might customize their layout of the admission form one way when they are working at one hospital.", "It might need to be customized another way at a different hospital.", "Traditionally, preferences are stored in a separate data store or stored locally on a client workstation.", "The system retrieves the content and preferences separately, and then the system alters the content based on the preference.", "This requires the consumer of the content to be aware of the preference system and also requires the consumer to alter the content.", "An example of a traditional preference application is an admissions screen for collecting new patient information.", "The system may want to allow users to choose if the form was displayed vertically or horizontally.", "The form itself could be saved as content in a content repository.", "The system could save the preference, vertical or horizontal, in the preference storage.", "The application would need to retrieve the form, and then it would need to read the preference for the user and modify the form to appear the way the preference indicated.", "This requires the application to be programmed in a way that it knows what all the possible preference are, and it would have to know how to modify the form to fit those preferences at runtime.", "In certain examples, a clinical information system provides functionality for users to define what the preferences are based on each hierarchical context as needed or desired.", "The CIS should then provide a correct admission process for the context that exists at admission time.", "Certain examples provide an intelligent, preference-based content system capable of storing hierarchical-based preferences.", "Certain examples store content for each preference separately.", "A consumer passes in a context when requesting content, and the content for those preference(s) is returned.", "There is no need for the consumer to analyze the preferences or alter the content.", "In the patient admission example, an admission form is stored as content to be used by default in the application.", "If a care provider prefers to change the admission form, the user specifies the desired change, and the system stores that form as content in the content system.", "The new content is stored with context information that includes the specific user.", "When the system retrieves the admission form, the system identifies that the context includes the specific user, and the content for that user is used.", "The content storage is aware of the context, but the consumer did not need to know what the preference was and did not need to alter the content.", "Language provides another example of how a preference can be stored as content.", "A patient discharge form can be stored by default in English.", "In a bilingual hospital, care providers may speak two languages, but a patient may only speak one language or the other.", "A second discharge form can be stored as content with a context indicating that it is in a second language different from a first language (e.g., a discharge form in Spanish and a discharge form in English).", "The patient's language is included as part of the context when retrieving the discharge form from the intelligent, preference-based content system.", "The application then displays the correct discharge form.", "In certain examples, by storing preferences as content, preferences do not need a separate data store.", "Preferences can be assigned that are user and/or patient specific.", "Preferences are stored as content, so a consumer of the content does not need to have a knowledge of the preference system.", "Preferences can follow a user across workstations and/or be centrally managed, for example.", "In certain examples, the system and associated software is flexible and configurable by end users.", "The flexibility and configurability should improve adoption by and usefulness for clinicians, for example.", "Context-based preference configuration and storage can be provided as part of an enterprise clinical information system, such as GE's Qualibria® system, for example.", "Certain examples resolve multiple variants of a content item based on who, what, and/or where the content consumer is.", "This allows consumers to create, specialize, and/or customize their own content on top of vendor-released content (e.g., shareable and interoperable content).", "This allows for a single content type to vary by properties associated with the content consumer without the need to customize every application that consumes that content to be aware of the rules necessary to vary the display of the content.", "In clinical applications, there are often times that information and data are to be displayed in different ways based on a context of application use.", "A role of a clinician may impact what clinical information he or she wants and/or needs to see and how he/she wants or needs to see it.", "A location of a user may also impact a type of information that is desired to be displayed based on clinical need, preference, etc.", "Clinical information may also be displayed in one or more languages, especially for patients.", "Resolution of context by an application allows appropriate information to be displayed based on who, what, and/or where the user of the application is.", "This ability enables streamlined workflows and targeted documentation for clinical use.", "This also gives flexibility to customize content for specific use(s).", "Previous attempts have included multiple modules in an application that are developed for a specific role or location, thus allowing customers to configure and/or copy parts of an application in order to meet specific context needs.", "This requires that all applications that use this content also use this code, thus forcing re-deployment of the application.", "Also, externally developed applications would not be able to take advantage of the rules applied to the context resolution.", "Thus, a single content item could be created that hides or shows parts based on parameters passed in.", "This would require complex algorithms during display to parse the content and modify it based on parameters.", "It would also have to be duplicated everywhere the content was used.", "Another option is to provide different content items without context resolution and have the consuming application select the correct content item based on algorithms developed per application.", "Alternatively, a heuristic rules engine could be implemented that would preclude the need for a context resolution algorithm as you could have several separate content items and have the rules engine determine which item would be appropriate to return.", "FIG.", "12 illustrates an example of runtime context resolution using an input context 1210 and a pool of variants 1220.As shown in the example of FIG.", "13, at 1310, conflicting variants are rejected.", "As shown in the example of FIG.", "14, at 1410, more specific context variants are rejected.", "As shown in the example of FIG.", "15, at 1510, of the remaining variants, a most specific variant to the input context is accepted to resolve the input context into a context variant.", "FIGS.", "16-18 provide another example of runtime context resolution by, first, rejecting conflicting variants; next, rejecting more specific context variants; and then, accepting a most specific of the remaining variants for the input context.", "As illustrated in the example of FIG.", "19, context resolution may occur at packaging time.", "First, as illustrated in the example of FIG.", "20, conflicting context variants are rejected.", "As shown in the example of FIG.", "21, conflicting context variants may be further eliminated based on an input context at packaging time.", "FIG.", "22 illustrates an example content management services system 2200.Content management services 2200 includes interrelationships of content storage, directory, lifecycle management, and packaging services.", "Packaging includes distribution and dependent management services, for example.", "The example content management services system 2200 manages content lifecycle.", "The example system 2200 includes an interface 2210, which connects to a content manager 2220.The content manager 2220 connects with content storage services 2230, content directory services 2240, content packaging services 2250, and content lifecycle services 2260.Content storage services 2230 includes an interface 2231 providing access to structured and unstructured content storage 2232-2233 and interacts with a data services foundation for document storage services 2270 for structured and/or unstructured document services 2270-2271.Content directory services 2240 provides, via an interface 2241, content searching 2242 along with a content directory manager 2243.The manager 2243 accesses content metadata management 2244 and content version management 2245, for example.", "Content directory services 2240 include a directory store 2246 and a metadata store 2247, for example.", "Content packaging services 2250 include an interface 2251 providing access to a content packaging manager 2252.The manager 2252 interacts with content distribution services 2253, content dependency management services 2254, and content packaging services 2255.Content distribution services 2253 connect to a content package export 2256 and content package export 2257.Content dependency management services 2254 and content packaging services 2255 communicate with a dependency map and package store 2258.Content packaging services 2255 also communicates with a content-type package plug-in 2259, which communicates with a terminology foundation 2280, in the example of FIG.", "22.As shown in FIG.", "22, the interface 2251 communicates with a serviceability foundation 2282 and a content services foundation 2284.Content lifecycle services 2260 includes an interface 2261 for a content lifecycle manager 2262 which connects to storage 2263.The content lifecycle manager 2262 interacts with a workflow and activity management foundation 2290.FIG.", "23 illustrates another example content management services system 2300.In the example of FIG.", "23, the system 2300 includes a content storage service 2310, a content directory service 2320, an active content loading and retrieval service 2330, a content deployment service 2340, a content management service 2350, a content packaging and distribution service 2360, a content lifecycle manager 2370, and a content type manager 2380.Components of the example system 2300 operate as described above with respect to managing, storing, loading, deploying, etc., content in a content-driven system and/or process.", "FIG.", "24 illustrates a flow diagram for an example method 2400 of creating and managing a clinical application in a content-based system.", "At block 2410, terminology is used to interpret one or more content items including associated data.", "For example, content including lab tests can be evaluated to determine the lab test name(s) using the available terminology.", "Terminology may be common and coded across a customer base and/or particularly designed for a customer, for example.", "Clinical content includes structured knowledge components such as decision support rules, protocols, reports, user preferences (e.g.", "triage form layout) and unstructured knowledge components such as discharge instructions, and guidelines.", "Content can include and/or be associated with clinical decision support.", "At block 2420, the one or more content items (e.g., instances of a content class) from one or more content classes are associated according to one or more detailed clinical models (e.g., CEMs).", "For example, data for lab test results identified using the terminology can be modeled using CEMs.", "In certain examples, a detailed clinical model defines, at a granular level, the structure and content of a data element.", "A detailed clinical model pulls the information together into a single, explicit, and computable form.", "The detailed clinical models or clinical element models (CEMs) govern the content and structure of data objects stored in an example clinical repository and used by one or more clinical applications, for example.", "In addition, CEMs are extensible, such that content authors may add new CEMs or attributes to existing CEMs without requiring major changes to database structures or software, for example.", "At block 2430, a formlet is formed from the one or more associated and modeled content items.", "A formlet provides a way to display a particular content item (e.g., a way to display a particular lab result).", "The formlet is formed according to a detailed clinical model, for example, organizing the associated content items, which are also organized according to one or more detailed clinical models, for example.", "At block 2440, a clinical application form is constructed from one or more formlets.", "For example, a detailed clinical model can be used to organize one or more formlets into a clinical application, such as a dashboard or other clinical information view.", "A clinical form definition provides an application or view (e.g., a dashboard) of a collection of formlets (e.g., a multi-patient view (MPV) showing one or more lab results and/or other information).", "For example, if a particular MPV definition is moved from one customer to another, the MPV definition along with other content items on which the form definition depends are imported into the new customer's knowledge repository.", "Content items may include appropriate formlets, CEMs, and terminology, for example.", "At block 2450, the application is packaged for deployment.", "For example, the application may be packaged in an executable, a container, a series of files to be compiled by a customer and/or at run time, etc.", "The content and data organized to form the clinical application can be transmitted together or separately to a customer site for installation and/or execution, for example.", "At block 2460, execution of the clinical application is facilitated.", "For example, packaged content (e.g., as a form including formlets including models organizing content according to a terminology) is provided for execution based on a reference platform.", "The reference platform facilitates content interpretation and management and also provides reference services to facilitate installation and execution of the clinical application by a customer.", "FIG.", "25 illustrates a flow diagram for an example method 2500 of content-driven clinical information management.", "At block 2510, content and data are organized in a repository and/or other electronic data store.", "For example, data (e.g., clinical and/or non-clinical data) relating to a patient, a condition, a diagnosis, a treatment, a best practice or other reference information can be stored in a repository, such as a clinical data repository.", "Content is an externalization or parameterization of “the instructions” that tell applications how to work.", "For example, content is a collection of externalized information that tells an application, in conjunction with data, how to behave.", "In certain examples, a clinical knowledge platform takes in and executes content against data to render applications visually and behaviorally.", "In certain examples, content can include data read and interpreted by a program to define or modify presentation, behavior, and/or semantics of the program and/or of application data consumed by the program, for example.", "Content includes documents presented to a client by a program without modification, for example.", "Content can be created, stored, deployed, and/or retrieved independently of the creation and deployment of the program(s) consuming the data, for example.", "Classes of content can include configuration content, preferences content, reference content, application content, etc.", "Content types can combine behaviors of two or more classes, for example.", "In certain examples, each content type is associated with a generic, extensible structure that particular content instances of the content type follow.", "A content item can be associated with a plurality of variants for one or more contexts (e.g., role, language, location, customer, department, clinical type, user context, patient context, etc.).", "A manual and/or automated selection of a variant can be made for a general content type.", "At block 2520, content can be authored as all (e.g., a form) or part (e.g., a formlet) of an application or view (e.g., a dashboard, such as a hospital-acquired conditions dashboard, rapid recovery dashboard, MPV, etc.).", "A clinical application can be generated using a terminology foundation for content and data, modeled according to one or more detailed clinical models, along with a dependency map illustrating relationships and dependencies between content/data according to the one or more clinical models.", "In certain examples, content can be scalable.", "For example, the process 2500 is scalable in that the process 2500 can support core content as determined by and/or for a particular application in addition to customer/competitor specific content.", "Content can be versionable to capture desired variation in program behavior and/or semantics, for example.", "The process 2500 is also expressive to allow end-users to consume the content to support individual preferences at an enterprise level, for example.", "At block 2530, content and data are packaged as one or more clinical applications.", "For example, application(s) can be packaged according to one or more detailed clinical data models (e.g., CEMs) organizing content and leveraging data according to the content and model(s).", "In certain examples, one or more clinical applications can be packaged differently according to customer, namespace, location, etc.", "At block 2540, the package can then be distributed or deployed to one or more targets for installation.", "The package can be distributed according to namespace, for example.", "Content can be distributed as a large set of items (e.g., a new installation), as one or more individual items (e.g., a bug fix), etc.", "A deployed content item is logically (and possibly physically) a different object than the content item being deployed.", "For example, a deployed content item has an independent state and lifecycle.", "Multiple content items can be created during deployment (e.g., deploying a CDL model can generate a CE Type object and an XML Schema).", "In certain examples, a source content item may not exist in the runtime system (e.g., the source CDL model is not deployed, the generated CE Type object is deployed).", "In certain examples, each deployed content item is bundled with content items used to execute or consume the item.", "For example, a bundle or content frame of items can be formed in a content package for deployment.", "At block 2550, the distributed content-based application is installed.", "The package can be a new installation, an update, an upgrade, a patch, etc.", "In certain examples, content dependencies are resolved upon installation.", "Content dependencies can also be resolved at packaging, on deployment, at runtime, etc.", "At block 2560, the content-based application is managed.", "For example, one or more content type managers interact with a content management frame to implement event handlers.", "Event handlers can handle dependencies between content items (e.g., between resolved context variants of content items).", "In certain examples, system management tools are provided to further create, export, import, and/or deploy content packages.", "In certain examples, a content frame including deployed content items is loaded from storage and made available for use by one or more running applications.", "Content items in the content frame can be translated during loading, for example, to resolve terminology designations, retrieve pick-lists, etc.", "In certain examples, a content type manager determines whether to translate at retrieval time, load time, etc.", "In certain examples, lifecycle management involves a set of workflows that manage transition of a content item from one state to another (e.g., via a set of states and state transitions represented as a state machine for a content type).", "Each state in the content type state machine is associated with a workflow that manages the content item when in that state.", "Workflows can be represented as content items to allow variation across system implementations.", "Certain examples also provide semantic interoperability.", "The process 2500 provides an infrastructure for clinical entities to create semantically interoperable systems to derive clinical, research and business benefits thereof In certain examples, the process 2500 enables modular content packaging and pluggable deployment.", "This flexibility allows tailorable content to support different types of clients to augment a “surround and supplement strategy”, wherein a small client with limited budget can go live with only couple of modules/content-deployers while a large enterprise customer might want a whole suite of content management infrastructure.", "Certain examples define processes apriori to help ensure that structured and unstructured clinical content development and management is predictable, measurable, efficient and integrated into application lifecycle management.", "Building a clinical application using the content management process 2500 provides significant benefits by making it scalable, expressive, standards supportive, semantically interoperable, and flexible.", "Certain examples provide a customizable application separate from a maintainable system.", "The clinical information system application is implemented in content, that is, as a set of content items that are created and maintained independently of the system, often by the customers of the system themselves.", "The reference platform (e.g., the system) is maintained, enhanced, tested, and deployed using traditional development techniques by the vendor.", "Since the application (e.g., in content) is independent of the reference platform, the two can evolve largely independently of each other.", "This allows a much greater degree of possible customization without reducing the maintainability of the system.", "Clinical information systems (CIS) that are content-driven provide functionality that improves clinical outcomes by enhancing compliance with institutionally/nationally recognized standards of care and reduce practice variation.", "A new process has been defined to streamline the clinical content management from its inception to its consumption by the CIS.", "FIG.", "26 illustrates a flow diagram for an example method 2600 of heuristic content resolution in an extensible content management system.", "For example, a particular content item, such as content item 510 shown in FIG.", "5, may have a plurality of context variants which may in turn have a plurality of context variants.", "A heuristic and/or other algorithm can be applied to identify an appropriate (e.g., a most appropriate) context variant for a particular content item based on one or more criterion (e.g., a user's current context).", "This can be referred to as context resolution.", "Context resolution involves conditioning a selection, composition, and/or behavior of a content item based on a specified value, such as a context of the user.", "FIGS.", "12-21 illustrate examples of heuristic variant determination as described further in connection with the method 2600 of FIG.", "26.Context resolution can occur at three levels, for example: selection of a content item, selection of a content frame, and translation of a content item.", "Selection of one or more content items on which a content item being deployed is dependent can occur based on context, for example.", "Selection of a content frame based on context can occur when the content frame is retrieved by an application.", "Translation of a content item based on context can occur when loading or retrieving a content frame.", "Multiple variants of a content item can be resolved based on who, what, or where the content consumer is, for example.", "This allows users to create, specialize, and/or customize their own content on top of default or vendor-released content (e.g., shareable and interopeable content).", "This allows for a single content type to vary by properties associated with the content consumer without having to customize every application that consumes a particular content item to be aware of the appropriate rules to vary the display of the content.", "In clinical applications, content can be displayed in different ways based on a context of application use.", "For example, a role of a clinician may impact what clinical information the user wants to see and how the user wants to see it.", "A location of a user can also impact the type of information that is desired to be displayed based on clinical need and preference, for example.", "There is also a need to display clinical information in multiple languages, especially for patients.", "At block 2610, a content item is identified.", "The content item can be identified in conjunction with a formlet combining a plurality of content items according to one or more clinical element models, for example.", "The formlet may be part of a form to provide information and functionality to a user according to one or more clinical element models, for example.", "Identification and context resolution can occur at runtime, at packaging, etc.", "At block 2620, available context variants for the content item are identified.", "For example, a content item can be stored in a clinical repository along with a plurality of context variants and an indication of the available context variants for that content item.", "Context variants can be identified based on an input context value or values (e.g., metadata associated with the content indicating user, role, location, namespace, department, etc.)", "provided at runtime, packaging time, etc., for example.", "At block 2630, conflicting context variants are rejected.", "For example, if an input context indicates a language of “English” and a role of “nurse”, then conflicting variants from the pool of variants including “French”, “doctor”, etc., are rejected or eliminated from consideration.", "At block 2640, more specific context variants are rejected.", "For example, for an input context of English nurse (e.g., “en/nurse”), context variants that provide additional detail/variation, such as Labor and Delivery (e.g., LDS), Labor and Delivery Nurse, etc., are eliminated or removed from consideration.", "At block 2650, a most specific variant of the remaining context variants for that content item, is selected.", "For example, continuing the English nurse context input example, remaining variants English (e.g., “en”) and English nurse (e.g., “en/nurse”) are reviewed to select a most specific remaining variant (e.g., as shown in FIGS.", "14-15).", "In this example, that context variant is Triage English nurse.", "That context variant is selected for use as the particular content item for the clinical application (e.g., a formlet forming part of a form).", "Resolution of context by an application allows appropriate information to be displayed based on who, what, and/or where the user of the application is.", "This ability enables streamlined workflows and targeted documentation for clinical use.", "This also gives flexibility to customize content for specific use(s).", "Thus, context selection or resolution utilizes a heuristic to resolve ambiguity or conflict among available context variants (e.g., weighting or priority schemes, default rules, etc.).", "Changing/adding a context variant, changing weight of a context attribute, etc., can change context resolution on another content item, for example.", "While an example manner of implementing systems and methods have been illustrated in the figures, one or more of the elements, processes and/or devices illustrated in the figures may be combined, divided, re-arranged, omitted, eliminated and/or implemented in any other way.", "Further, one or more components and/or systems may be implemented by hardware, software, firmware and/or any combination of hardware, software and/or firmware.", "Thus, for example, any of the example components and/or systems may be implemented by one or more circuit(s), programmable processor(s), application specific integrated circuit(s) (ASIC(s)), programmable logic device(s) (PLD(s)) and/or field programmable logic device(s) (FPLD(s)), etc.", "When any of the appended claims are read to cover a purely software and/or firmware implementation, at least one of the example components and/or systems are hereby expressly defined to include a tangible medium such as a memory, DVD, Blu-ray, CD, etc., storing the software and/or firmware.", "Further still, any of the example systems may include one or more elements, processes and/or devices in addition to, or instead of, those illustrated in the figures, and/or may include more than one of any or all of the illustrated elements, processes and devices.", "The flow diagrams depicted in the figures are representative of machine readable instructions that can be executed to implement example processes and/or systems described herein.", "The example processes may be performed using a processor, a controller and/or any other suitable processing device.", "For example, the example processes may be implemented in coded instructions stored on a tangible medium such as a flash memory, a read-only memory (ROM) and/or random-access memory (RAM) associated with a processor (e.g., the example processor 2712 discussed below in connection with FIG.", "27).", "Alternatively, some or all of the example processes may be implemented using any combination(s) of application specific integrated circuit(s) (ASIC(s)), programmable logic device(s) (PLD(s)), field programmable logic device(s) (FPLD(s)), discrete logic, hardware, firmware, etc.", "Also, some or all of the example processes may be implemented manually or as any combination(s) of any of the foregoing techniques, for example, any combination of firmware, software, discrete logic and/or hardware.", "Further, although the example processes are described with reference to the figures, other methods of implementing the processes of may be employed.", "For example, the order of execution of the blocks may be changed, and/or some of the blocks described may be changed, eliminated, sub-divided, or combined.", "Additionally, any or all of the example processes of may be performed sequentially and/or in parallel by, for example, separate processing threads, processors, devices, discrete logic, circuits, etc.", "FIG.", "27 is a block diagram of an example processor system 2710 that may be used to implement the apparatus and methods described herein.", "As shown in FIG.", "27, the processor system 2710 includes a processor 2712 that is coupled to an interconnection bus 2714.The processor 2712 may be any suitable processor, processing unit or microprocessor.", "Although not shown in FIG.", "27, the system 2710 may be a multi-processor system and, thus, may include one or more additional processors that are identical or similar to the processor 2712 and that are communicatively coupled to the interconnection bus 2714.The processor 2712 of FIG.", "27 is coupled to a chipset 2718, which includes a memory controller 2720 and an input/output (I/O) controller 2722.As is well known, a chipset typically provides I/O and memory management functions as well as a plurality of general purpose and/or special purpose registers, timers, etc.", "that are accessible or used by one or more processors coupled to the chipset 2718.The memory controller 2720 performs functions that enable the processor 2712 (or processors if there are multiple processors) to access a system memory 2724 and a mass storage memory 2725.The system memory 2724 may include any desired type of volatile and/or non-volatile memory such as, for example, static random access memory (SRAM), dynamic random access memory (DRAM), flash memory, read-only memory (ROM), etc.", "The mass storage memory 2725 may include any desired type of mass storage device including hard disk drives, optical drives, tape storage devices, etc.", "The I/O controller 2722 performs functions that enable the processor 2712 to communicate with peripheral input/output (I/O) devices 2726 and 2728 and a network interface 2730 via an I/O bus 2732.The I/O devices 2726 and 2728 may be any desired type of I/O device such as, for example, a keyboard, a video display or monitor, a mouse, etc.", "The network interface 2730 may be, for example, an Ethernet device, an asynchronous transfer mode (ATM) device, an 802.11 device, a DSL modem, a cable modem, a cellular modem, etc.", "that enables the processor system 2710 to communicate with another processor system.", "While the memory controller 2720 and the I/O controller 2722 are depicted in FIG.", "27 as separate blocks within the chipset 2718, the functions performed by these blocks may be integrated within a single semiconductor circuit or may be implemented using two or more separate integrated circuits.", "Certain embodiments contemplate methods, systems and computer program products on any machine-readable media to implement functionality described above.", "Certain embodiments may be implemented using an existing computer processor, or by a special purpose computer processor incorporated for this or another purpose or by a hardwired and/or firmware system, for example.", "Certain embodiments include computer-readable media for carrying or having computer-executable instructions or data structures stored thereon.", "Such computer-readable media may be any available media that may be accessed by a general purpose or special purpose computer or other machine with a processor.", "By way of example, such computer-readable media may comprise RAM, ROM, PROM, EPROM, EEPROM, Flash, CD-ROM or other optical disk storage, magnetic disk storage or other magnetic storage devices, or any other medium which can be used to carry or store desired program code in the form of computer-executable instructions or data structures and which can be accessed by a general purpose or special purpose computer or other machine with a processor.", "Combinations of the above are also included within the scope of computer-readable media.", "Computer-executable instructions comprise, for example, instructions and data which cause a general purpose computer, special purpose computer, or special purpose processing machines to perform a certain function or group of functions.", "Generally, computer-executable instructions include routines, programs, objects, components, data structures, etc., that perform particular tasks or implement particular abstract data types.", "Computer-executable instructions, associated data structures, and program modules represent examples of program code for executing steps of certain methods and systems disclosed herein.", "The particular sequence of such executable instructions or associated data structures represent examples of corresponding acts for implementing the functions described in such steps.", "Embodiments of the present invention may be practiced in a networked environment using logical connections to one or more remote computers having processors.", "Logical connections may include a local area network (LAN) and a wide area network (WAN) that are presented here by way of example and not limitation.", "Such networking environments are commonplace in office-wide or enterprise-wide computer networks, intranets and the Internet and may use a wide variety of different communication protocols.", "Those skilled in the art will appreciate that such network computing environments will typically encompass many types of computer system configurations, including personal computers, hand-held devices, multi-processor systems, microprocessor-based or programmable consumer electronics, network PCs, minicomputers, mainframe computers, and the like.", "Embodiments of the invention may also be practiced in distributed computing environments where tasks are performed by local and remote processing devices that are linked (either by hardwired links, wireless links, or by a combination of hardwired or wireless links) through a communications network.", "In a distributed computing environment, program modules may be located in both local and remote memory storage devices.", "Although certain methods, apparatus, and articles of manufacture have been described herein, the scope of coverage of this patent is not limited thereto.", "To the contrary, this patent covers all methods, apparatus, and articles of manufacture fairly falling within the scope of the appended claims either literally or under the doctrine of equivalents." ] ]
Patent_15874390
[ [ "PROCESSING CIRCUIT SWITCHED SERVICES IN AN EVOLVED PACKET NETWORK", "The present invention discloses for the ability for processing circuit switched (CS) services in an evolved packet network.", "For example, embodiments provide a method that includes: by a mobility management entity (MME), receiving a mobile terminated (MT) service indication from a mobile switching center (MSC); sending the MT service indication to user equipment (UE); and receiving an MT service response returned by the UE and performing subsequent operations according to the MT service response.", "In the method of the present invention, when an MT service arrives, the MME does not trigger the evolved NodeB (eNodeB) to hand over the packet switched (PS) services of the UE but notifies the UE of the MT service and performs subsequent operations according to the MT service response returned by the UE, thus avoiding the waste of network resources caused by a meaningless handover of PS services." ], [ "1.A method for processing circuit switched services, comprising: receiving, by a mobility management entity, an mobile terminated service request from a user equipment, wherein the mobile terminated service request carries a choice result; if the choice result is to hold the mobile terminated service, sending, by the mobility management entity, a mobile terminated service hold message to a mobile switching center; receiving, by the mobility management entity, a first mobile terminated service activation request from the user equipment that requests restoration of the held mobile terminated service; sending, by the mobility management entity, a second mobile terminated service activation request to the mobile switching center; and returning, by the mobile switching center, a second mobile terminated service activation response to the mobility management entity, notifying the user equipment to access the 2G/3G network.", "2.The method of claim 1, wherein the mobile terminated service activation request carries an mobile terminated service ID and the step of returning the second mobile terminated service activation response to the mobility management entity comprises: by the mobile switching center, matching the mobile terminated service ID with a held mobile terminated service, and if the mobile terminated service exists, accepting the activation request and sending the second mobile terminated service activation response to the mobility management entity.", "3.The method of claim 1, wherein the mobile terminated service indication comprises mobile terminated service related information.", "4.A method for processing circuit switched services in an evolved packet network, comprising: receiving, by a mobility management entity, a short message from a mobile switching center; by the mobility management entity, sending the short message to a user equipment if the user equipment is active and activating the user equipment and sending the short message to the user equipment if the user equipment is idle; and receiving, by the mobility management entity, a short message response from the user equipment.", "5.The method of claim 4, wherein the step of activating the user equipment and sending the short message to the user equipment comprises: sending, by the mobility management entity, a second page message to an evolved NodeB (eNodeB); broadcasting, by the eNodeB, the second page message to user equipments in a cell managed by the eNodeB; receiving, by the mobility management entity, a service request from the user equipment; and sending, by the mobility management entity, the short message to the user equipment according to the service request.", "6.The method of claim 4 wherein the step of activating the user equipment and sending the short message to the user equipment comprises: sending, by the mobility management entity, a third page message that carries the short message to an evolved NodeB (eNodeB); and broadcasting, by the eNodeB, the third page message to user equipments in a cell managed by the eNodeB.", "7.A non-transitory computer readable medium, comprising computer program code storing instructions which that, when executed by a computer unit processor, will cause the computer unit processor to perform a method, wherein the method comprises the steps of: receiving receive a message notifying a mobile terminated service sent by a mobility management entity, wherein the mobile terminated service is a circuit switched service; and sending send an mobile terminated service response to the mobility management entity, wherein the mobile terminated service response indicates to accept the mobile terminated service, or reject the mobile terminated service.", "8.An apparatus comprising: a receiver, configured to receive a message notifying the apparatus of a mobile terminated service from a mobility management entity, wherein the mobile terminated service is a circuit switched service; and a sender, configured to return an mobile terminated service response to the mobility management entity, wherein the mobile terminated service response indicates to accept the mobile terminated service, or reject the mobile terminated service." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>To answer the challenge of wireless broadband technologies and maintain the leadership of the 3 rd Generation Partnership Project (3GPP) networks, the 3GPP organization prepared a long term evolution (LTE) plan at the end of 2004.Directed by the LTE plan, new mobile communications network architecture is defined, where only the packet switched (PS) domain remains.", "The architecture is called an evolved packet system (EPS).", "To enable circuit switched (CS) services in an EPS network, a prior art provides a method for processing CS services in an EPS network, which may be described as a CS fallback method.", "When a mobile switching center (MSC) receives a mobile terminated (MT) service, such as a CS voice call, the MSC sends a page message to a mobility management entity (MME) and the MME pages user equipment (UE) via the EPS network.", "When an evolved NodeB (eNodeB) receives the page message, the eNodeB first executes a PS service handover, that is, the eNodeB hands over the ongoing PS service of the UE to the PS domain of a general packet radio service/universal mobile telecommunications system (GPRS/UMTS) network.", "Then, the eNodeB hands over the UE to a 2 nd generation/3 rd generation (2G/3G) network, that is, the UE chooses a 2G/3G cell to camp.", "When the UE returns a page response to the MSC in the GPRS/UMTS network, the UE completes processing of the MT service.", "During research and practice of the prior art, however, the inventor finds that the prior art has at least the following weaknesses: By using the CS fallback method in the prior art, the eNodeB executes a PS service handover immediately when receiving the page message from the MME, which results in the following problems: 1.Waste of network resources.", "According to the prior art, when an MT service arrives, the eNodeB hands over the PS service to the PS domain of a 2G/3G network and connects the MT service.", "In practice, the following case often happens: When the UE is handed over to a 2G/3G network and an MT service is connected, the user rejects the MT service because the user is unwilling or unable to answer.", "The base station subsystem/radio network controller (BSC/RNC) regards such MT services as services that have been completed and the BSC/RNC then hands over the PS services of the UE to the EPS network.", "Two PS service handovers are performed for an MT service that is not normally executed, and therefore network resources are wasted.", "2.Impact on the ongoing PS service of the UE.", "For example, a UE is in a PS service (such as a video conference) in an EPS network when it receives a CS MT service (such as a private call).", "According to the prior art, the eNodeB hands over the video conference to the PS domain a 2G/3G network, but because the PS domain of the 2G/3G network does not support certain PS services in the EPS network, such as the video conference, the PS service will fail.", "Thus, the prior art impacts the ongoing PS services." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Embodiments of the present invention provide a method, system and device for processing CS services in an evolved packet network so as to avoid the waste of network resources and not to impact the current PS services of a UE.", "For the above purpose, the embodiments of the present invention are implemented via the following technical solution: A method for processing CS services in an evolved packet network includes: receiving, by an MME, an MT service indication from an MSC; sending, by the MME, the MT service indication to a UE; and by the MME, receiving an MT service response returned by the UE and performing subsequent operations according to the MT service response.", "A method for processing CS services in an evolved packet network includes: receiving, by an MME, a short message from an MSC; by the MME, sending the short message to a UE if the UE is in active mode and activating the UE and sending the short message to the UE if the UE is in idle mode; and receiving, by the MME, a short message response from the UE.", "An MME includes: a page message receiving unit, configured to receive an MT service indication from an MSC; an MT service notifying unit, configured to send the MT service indication to a UE; a response receiving unit, configured to receive an MT service response returned by the UE; and a response processing unit, configured to perform subsequent operations according to the MT service response.", "An MME includes: a receiving unit, configured to receive a short message from an MSC; a state judging unit, configured to judge whether a UE is in active or idle mode; a sending unit, configured to send the short message received by the receiving unit to the UE when the state judging unit determines that the UE is in active mode; an activating and sending unit, configured to activate the UE when the state judging unit determines that the UE is in idle mode and send the short message received by the receiving unit to the activated UE; and a short message response receiving unit, configured to receive a short message response from the UE.", "A UE includes: a notification receiving unit, configured to receive an MT service indication sent by an MME; an notifying unit, configured to notify the user of the MT service after the notification receiving unit receives the MT service indication; and a response sending unit, configured to return an MT service response to the MME according to a choice of the user regarding the MT service.", "A system for processing CS services in an evolved packet network includes an MSC and an MME, where: the MSC includes a service indication sending unit, configured to send an MT service indication to the MME after receiving the MT service indication; the MME includes: a page message receiving unit, configured to receive the MT service indication from the MSC; an MT service notifying unit, configured to send the MT service indication to a UE; a response receiving unit, configured to receive an MT service response returned by the UE; and a response processing unit, configured to perform subsequent operations according to the MT service response.", "The technical solution provides the following benefits: In the embodiments of the present invention, when a CS MT service arrives, the MME sends an MT service indication to notify the UE of the MT service and then performs subsequent operations according to an MT service response received from the UE.", "When the MT service arrives, the MME does not trigger the eNodeB to hand over the PS service of the UE, but notifies the UE of the MT service and carries out subsequent processing according to the MT service response returned by the UE.", "Thus, the embodiments of the present invention avoid the waste of network resources caused by a meaningless PS service handover and do not impact the ongoing PS services of the UE." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/859,196, filed on Sep. 18, 2015, which is a continuation of U.S. patent application Ser.", "No.", "13/924,606, filed on Jun.", "23, 2013, now U.S. Pat.", "No.", "9,161,269.The U.S. patent application Ser.", "No.", "13/924,606 is a continuation of U.S. patent application Ser.", "No.", "12/831,437, filed on Jul.", "7, 2010, now U.S. Pat.", "No.", "8,493,934.The U.S. patent application Ser.", "No.", "12/831,437 is a continuation of International Application No.", "PCT/CN2008/073200, filed on Nov. 26, 2008, which claims priority to Chinese Patent Application 200810002762.X, filed on Jan. 16, 2008.The afore-mentioned patent applications are hereby incorporated by reference in their entireties.", "FIELD OF THE INVENTION The present invention relates to communications technologies, and in particular, to processing circuit switched services in an evolved packet network.", "BACKGROUND OF THE INVENTION To answer the challenge of wireless broadband technologies and maintain the leadership of the 3rd Generation Partnership Project (3GPP) networks, the 3GPP organization prepared a long term evolution (LTE) plan at the end of 2004.Directed by the LTE plan, new mobile communications network architecture is defined, where only the packet switched (PS) domain remains.", "The architecture is called an evolved packet system (EPS).", "To enable circuit switched (CS) services in an EPS network, a prior art provides a method for processing CS services in an EPS network, which may be described as a CS fallback method.", "When a mobile switching center (MSC) receives a mobile terminated (MT) service, such as a CS voice call, the MSC sends a page message to a mobility management entity (MME) and the MME pages user equipment (UE) via the EPS network.", "When an evolved NodeB (eNodeB) receives the page message, the eNodeB first executes a PS service handover, that is, the eNodeB hands over the ongoing PS service of the UE to the PS domain of a general packet radio service/universal mobile telecommunications system (GPRS/UMTS) network.", "Then, the eNodeB hands over the UE to a 2nd generation/3rd generation (2G/3G) network, that is, the UE chooses a 2G/3G cell to camp.", "When the UE returns a page response to the MSC in the GPRS/UMTS network, the UE completes processing of the MT service.", "During research and practice of the prior art, however, the inventor finds that the prior art has at least the following weaknesses: By using the CS fallback method in the prior art, the eNodeB executes a PS service handover immediately when receiving the page message from the MME, which results in the following problems: 1.Waste of network resources.", "According to the prior art, when an MT service arrives, the eNodeB hands over the PS service to the PS domain of a 2G/3G network and connects the MT service.", "In practice, the following case often happens: When the UE is handed over to a 2G/3G network and an MT service is connected, the user rejects the MT service because the user is unwilling or unable to answer.", "The base station subsystem/radio network controller (BSC/RNC) regards such MT services as services that have been completed and the BSC/RNC then hands over the PS services of the UE to the EPS network.", "Two PS service handovers are performed for an MT service that is not normally executed, and therefore network resources are wasted.", "2.Impact on the ongoing PS service of the UE.", "For example, a UE is in a PS service (such as a video conference) in an EPS network when it receives a CS MT service (such as a private call).", "According to the prior art, the eNodeB hands over the video conference to the PS domain a 2G/3G network, but because the PS domain of the 2G/3G network does not support certain PS services in the EPS network, such as the video conference, the PS service will fail.", "Thus, the prior art impacts the ongoing PS services.", "SUMMARY OF THE INVENTION Embodiments of the present invention provide a method, system and device for processing CS services in an evolved packet network so as to avoid the waste of network resources and not to impact the current PS services of a UE.", "For the above purpose, the embodiments of the present invention are implemented via the following technical solution: A method for processing CS services in an evolved packet network includes: receiving, by an MME, an MT service indication from an MSC; sending, by the MME, the MT service indication to a UE; and by the MME, receiving an MT service response returned by the UE and performing subsequent operations according to the MT service response.", "A method for processing CS services in an evolved packet network includes: receiving, by an MME, a short message from an MSC; by the MME, sending the short message to a UE if the UE is in active mode and activating the UE and sending the short message to the UE if the UE is in idle mode; and receiving, by the MME, a short message response from the UE.", "An MME includes: a page message receiving unit, configured to receive an MT service indication from an MSC; an MT service notifying unit, configured to send the MT service indication to a UE; a response receiving unit, configured to receive an MT service response returned by the UE; and a response processing unit, configured to perform subsequent operations according to the MT service response.", "An MME includes: a receiving unit, configured to receive a short message from an MSC; a state judging unit, configured to judge whether a UE is in active or idle mode; a sending unit, configured to send the short message received by the receiving unit to the UE when the state judging unit determines that the UE is in active mode; an activating and sending unit, configured to activate the UE when the state judging unit determines that the UE is in idle mode and send the short message received by the receiving unit to the activated UE; and a short message response receiving unit, configured to receive a short message response from the UE.", "A UE includes: a notification receiving unit, configured to receive an MT service indication sent by an MME; an notifying unit, configured to notify the user of the MT service after the notification receiving unit receives the MT service indication; and a response sending unit, configured to return an MT service response to the MME according to a choice of the user regarding the MT service.", "A system for processing CS services in an evolved packet network includes an MSC and an MME, where: the MSC includes a service indication sending unit, configured to send an MT service indication to the MME after receiving the MT service indication; the MME includes: a page message receiving unit, configured to receive the MT service indication from the MSC; an MT service notifying unit, configured to send the MT service indication to a UE; a response receiving unit, configured to receive an MT service response returned by the UE; and a response processing unit, configured to perform subsequent operations according to the MT service response.", "The technical solution provides the following benefits: In the embodiments of the present invention, when a CS MT service arrives, the MME sends an MT service indication to notify the UE of the MT service and then performs subsequent operations according to an MT service response received from the UE.", "When the MT service arrives, the MME does not trigger the eNodeB to hand over the PS service of the UE, but notifies the UE of the MT service and carries out subsequent processing according to the MT service response returned by the UE.", "Thus, the embodiments of the present invention avoid the waste of network resources caused by a meaningless PS service handover and do not impact the ongoing PS services of the UE.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a flowchart of a CS fallback method provided in an embodiment of the present invention; FIG.", "2 is a signaling flow of a CS fallback method provided in Embodiment 1 of the present invention; FIG.", "3 is a signaling flow where a UE is activated and notified of an incoming MT service in Embodiment 1 of the present invention; FIG.", "4 is a signaling flow of a CS fallback method provided in Embodiment 2 of the present invention; FIG.", "5 is a signaling flow where a UE is activated and notified of an incoming MT service in Embodiment 2 of the present invention; FIG.", "6 is a signaling flow of an MT service restoring method provided in an embodiment of the present invention; and FIG.", "7 shows a structure of a CS fallback system provided in an embodiment of the present invention.", "DETAILED DESCRIPTION OF THE INVENTION To better explain the purpose, technical solution and advantages of the present invention, the embodiments of the present invention are hereinafter described in detail with reference to the accompanying drawings.", "When a circuit switched (CS) mobile terminated (MT) service arrives, as shown in FIG.", "1, a CS fallback method provided in an embodiment of the present invention includes: Step 101: A mobility management entity (MME) receives an MT service indication from an mobile switching center (MSC).", "Step 102: The MME forwards the MT service indication to a user's equipment (UE).", "The MT service indication notifies the UE of an MT service.", "Step 103: The MME receives an MT service response from the UE.", "Step 104: The MME carries out subsequent processing according to the MT service response.", "The above is a CS fallback method provided in an embodiment of the present invention.", "In the embodiment, when a CS MT service arrives, the MME first sends an MT service indication to notify the UE of the MT service and after reception of the MT service response from the UE, the MME carries out subsequent processing according to the MT service response.", "In the method provided in the embodiment of the present invention, when an MT service arrives, the MME does not trigger the eNodeB to hand over the PS service of the UE, but notifies the UE of the MT service and carries out subsequent processing according to the MT service response returned by the UE.", "Thus, the method avoids the waste of network resources caused by a meaningless PS service handover and does not impact the ongoing PS service of the UE.", "In a specific implementation of the embodiment of the present invention, the MT service response may carry a user choice result.", "If the use chooses to reject the MT service, the MME returns an MT service Reject message to the MSC when the MME carries out subsequent processing according to the MT service response.", "If the user chooses to accept the MT service, the MME sends a PS service handover request to the eNodeB and the eNodeB executes a PS service handover when the eNodeB receives the handover request and hands the UE over to a 2G/3G network.", "After the UE is handed over to the 2G/3G network, the UE sends a first page response to the MSC and completes MT service processing.", "In another embodiment of the present invention, if the user chooses to accept the MT service, the MME does not hand over the current PS service of the UE according to a configured network operation policy and therefore, the MME does not need to send a PS service handover request to the eNodeB and the eNodeB does not need to execute a PS handover later.", "In this case, after the UE sends the response indicating acceptance of the MT service, or receives a response from the MME regarding the UE's acceptance of the MT service, the UE accesses the 2G/3G network directly to complete the MT service processing.", "The above describes the CS fallback method provided in an embodiment of the present invention.", "The following describes specific signaling flows of the method.", "As shown in FIG.", "2, a signaling flow of the CS fallback method in Embodiment 1 of the present invention includes: Step 201: The MSC receives an MT service indication and sends a first page message to the MME.", "In practice, the first page message may carry an international mobile subscriber identity (IMSI) of the UE.", "Step 202: When receiving the first page message, the MME queries the UE state.", "If the UE is in idle mode, the MME sends a second page message to the eNodeB.", "If the UE is in active mode, the process proceeds to step 205.In practice, the first page message may carry the MT service indication sent by the MSC to the MME.", "Therefore, the first page message may be named MT service request or alike.", "In addition, if the first page message carries the MT service indication, in step 302, after the MME receives the first page message, the MME needs to parse the first page message and query the UE state after the MT service indication is obtained.", "In addition, the first page message may not carry the MT service indication.", "In this case, the MME is set to query the UE state once it receives the first page message.", "In this case, the first page message is equivalent to an MT service indication.", "Step 203: The eNodeB broadcasts the second page message in the cell it manages.", "Step 204: The UE receives the second page message and returns a service request to the MME.", "The MME sends the second page message via the eNodeB to activate the idle UE.", "Step 205: After receiving of the service request, the MME sends an MT service indication to the UE.", "The MT service indication is intended to notify the UE of the MT service.", "The MT service indication shown in FIG.", "2 is a non access stratum (NAS) message and therefore it may be sent to the UE directly from the MME.", "In another embodiment of the present invention, the MT service indication is an access stratum message (such as Page).", "The access stratum message may carry the MT service indication and is sent by the MME to the eNodeB and forwarded by the eNodeB to the UE.", "This does not impact the implementation of the present invention.", "Step 206: After the UE receives the MT service indication, the UE notifies the user of the MT service.", "In practice, the UE notifies the user of the MT service according to the presetting of the user.", "For example, the UE may ring, or vibrate, or ring and vibrate, or give a text notify, to notify the user of the MT service.", "After the user makes a choice regarding the MT service, the UE executes step 207.Step 207: The UE sends an MT service response to the MME.", "The MT service response may carry the user choice result (accept or reject) or the MT service response does not carry a user choice result, that is, the user choice result is null.", "If the MT service response does not carry a user choice result, the MME may decide the user choice according to default settings.", "A common scenario is that, if the MT service response does not carry the choice result, the MME thinks that the user accepts the MT service by default.", "Step 208: The MME obtains the choice result carried in the MT service response.", "If the user chooses to reject the MT service, the MME sends a first page reject message (the foregoing MT service reject).", "If the user chooses to accept the MT service, the process proceeds to step 209.If the UE rejects the MT service, it is unnecessary to execute the MT service and the MME returns a first page reject message to the MSC to end the MT service.", "In the method provided in the embodiment of the present invention, if the UE does not execute the MT service, the eNodeB does not hand over the PS service of the UE.", "Thus the method avoids the waste of network resources caused by a meaningless PS handover and will not impact the current PS service of the UE.", "The first page reject message may carry a cause value indicating the reason for rejecting the MT service or the message may not carry the cause value.", "Whether the message carries the cause value does not impact the implementation of the present invention.", "In addition, the case often happens in daily life that the user does not see or feel the notifying of the UE in a long time.", "To improve the work efficiency of the MME, it may be defined in advance that, if the MME does not receive the MT service response from the UE within a preset time T, the MME thinks that the user rejects the MT service.", "And in this case, the MME sends the first page reject message to the MSC to reject the MT service.", "Step 209: The MME sends a PS service handover request to the eNodeB.", "Step 210: The eNodeB receives the PS service handover request and initiates a PS service handover procedure to hand the UE over to the 2G/3G network.", "Step 211: After the UE is handed over to the 2G/3G network, the UE sends a first page response and completes the MT service processing.", "In another embodiment of the present invention, after the MME receives the first page message, the MME may not query the UE state but thinks the UE is in idle mode by default.", "Then, the MME sends a second page message and an MT service indication to the UE to notify the active or idle UE of the MT service.", "The above is a signaling flow provided in Embodiment 1 of the present invention.", "When the MME receives the first page message sent by the MSC in step 201, the MME may notify an idle or active UE of the MT service via steps 202-205 in Embodiment 1 of the present invention or via the signaling flow shown in FIG.", "3.The signaling flow includes: Step 301: The MME receives a first page message from the MSC and sends a third page message to the eNodeB.", "The third page message carries at least an MT service indication.", "In practice, the MT service indication may be a page cause value in the third page message or an independent information element in the third page message, which will not impact the implementation of the present invention.", "Step 302: The eNodeB broadcasts the third page message in the cell it manages.", "Step 303: After the UE receives the third page message, the UE notifies the user of the MT service.", "The signaling flow shown in FIG.", "3 is different from steps 202-205 in Embodiment 1 of the present invention in the following aspects: In Embodiment 1 of the present invention, the MME sends a message to notify the UE of an MT service only when the UE is in active mode.", "The UE may be already in active mode when the MME receives the first page message, or the UE may be activated through paging by the MME.", "In the signaling flow shown in FIG.", "3, however, the MME does not check whether the UE is in active mode but notifies the UE of an MT service directly via a third page message.", "Specifically, in Embodiment 1 of the present invention, when the UE is in idle mode, the MME sends the second page message and the MT service indication to notify the UE of the MT service; when the UE is in active mode, the MME sends the MT service indication directly to notify the UE of the MT service.", "The benefit of this signaling flow is that it does not impact the paging mechanism in the existing EPS network.", "In the signaling flow shown in FIG.", "3, the MME sends a third page message that carries the MT service indication to notify the UE of the MT service.", "The benefit is that it increases the processing efficiency of the MME and reduces the call delay.", "To let the UE know information of the MT service originator to help the user make a choice regarding the MT service, in the preceding and following embodiments of the present invention, the first page message sent by the MSC to the MME may further carry MT service related information.", "The MT service related information includes: a mobile station ISDN (MSISDN) of the originator, or a service type indication, such as short message service (SMS), location service (LCS), and unstructured supplementary service data (USSD).", "In addition, to help the MSC determine the MT service associated with the received MT service response, the MT service related information may further include an MT service ID that is allocated by the MSC or an existing ID (like a call number).", "Because the first page message sent by the MSC to the MME carries the MT service related information, the page message or MT service indication sent by the MME to the UE may further carry the MT service related information.", "In this case, the UE notifies the user of the MT service according to the received MT service related information according to the presetting of the user.", "For example, the UE may display the MSISDN of the originator to the user or notify the user of the service type.", "In the foregoing method, the user may choose to accept or reject the service.", "In certain scenarios, however, the user wishes to process the MT service after waiting for some time.", "It is therefore necessary to hold the MT service.", "Embodiment 2 of the present invention provides another CS fallback method.", "The method includes the following step based on the method shown in FIG.", "1: If the user chooses to hold the MT service, the MME sends an MT service Hold message to the MSC.", "In addition, to guarantee that the MT service is restorable, the method further includes: If the UE requests restoration of the held MT service, the MME notifies the MSC to restore the MT service; the MSC judges whether the MT service can be restored and if the service can be restored, the MSC notifies the UE of accessing the 2G/3G network via the MME and the UE then completes the MT service, or the MME triggers the eNodeB to hand the UE over to the 2G/3G network to complete the MT service according to a configured operation policy.", "If the MSC cannot restore the MT service, the restoration procedure is ended.", "FIG.", "4 shows a signaling flow of the CS fallback method in Embodiment 2 of the present invention.", "The signaling flow allows the user to choose to hold the MT service.", "The signaling flow includes: Step 401: The MSC receives an MT service request and sends a first page message to the MME.", "To avoid long-term MT service holding that consumes system resources, the method may further include a step of presetting a call hold timer and the first page message further carries the call hold timer length.", "Step 402: The MME queries the state of the UE associated with the IMSI.", "If the UE is in idle mode, the MME sends a fourth page message to the eNodeB.", "If the UE is in active mode, the process proceeds to step 405.Step 403: The eNodeB broadcasts the fourth page message in the cell it manages.", "Step 404: The UE receives the fourth page message and returns a service request to the MME.", "Step 405: The MME sends an MT service indication to the UE to notify the UE of an MT service.", "The ME service indication may or may not carry the MT service related information and/or the call hold timer length, which does not impact the implementation of the present invention.", "Step 406: After the UE receives the MT service indication, the UE notifies the user of the MT service.", "In practice, if the MT service indication carries the MT service related information, the UE notifies the user of the MT service according to the received MT service related information according to the presetting of the user.", "For example, the UE may display the MSISDN of the originator to the user or notify the user of the service type.", "The UE may ring, or vibrate, or ring and vibrate, or give a text notify to notify the user of the MT service.", "After the user makes a choice regarding the MT service, the UE executes step 407.Step 407: The UE sends an MT service response to the MME.", "The MT service response may carry the user choice result (accept or reject) or the MT service response does not carry a user choice result, that is, the user choice result is null.", "If the MT service response does not carry a user choice result, the MME may decide the user choice according to default settings.", "A common scenario is that, if the MT service response does not carry the choice result, the MME thinks that the user accepts the MT service by default.", "If the user chooses to hold the service, the UE starts the associated timer according to the call hold timer length.", "Step 408: The MME obtains the choice result carried in the MT service response.", "If the user chooses to hold the MT service, the MME sends an MT service Hold message to the MSC; if the user chooses to reject or accept the MT service, the subsequent steps are the same as the procedure provided in Embodiment 1 of the present invention.", "Step 409: The MSC starts the associated timer according to the preset call hold timer length.", "In another embodiment of the present invention, after the MME receives the first page message, the MME may not query the UE state but thinks the UE is in idle mode by default.", "Then, the MME sends the fourth page message and the MT service indication to the UE to notify the active or idle UE of the MT service.", "The above is a specific signaling flow of the CS fallback method provided in Embodiment 2 of the present invention.", "The active or idle UE may be notified of the MT service via steps 402-405.In another embodiment of the present invention, the signaling flow shown in FIG.", "5 may be adopted to notify an active or idle UE of an MT service.", "The signaling flow includes: Step 501: The MME receives a first page message from the MSC and sends a fifth page message to the eNodeB.", "The fifth page message carries at least an MT service indication.", "To avoid long-term MT service holding that consumes system resources and help the user make a choice regarding the MT service, the MT service request may further carry a preset call hold timer length and/or MT service related information.", "Step 502: The eNodeB broadcasts the fifth page message in the cell it manages.", "Step 503: After the UE receives the fifth page message, the UE notify the user of the MT service.", "The CS fallback method provided in the embodiments of the present invention and the specific implementation procedures are described above.", "For a user-held MT service, if the user chooses to continue the service, the MT service needs to be restored.", "When the user requests restoration of the MT service, if the UE starts a timer when the MT service is held, the UE needs to check whether the timer has expired.", "If the timer has expired, the restoration procedure is over.", "If the timer has not expired, the restoration procedure is executed.", "With respect to the above MT service restoration procedure, an embodiment of the present invention provides a signaling flow for MT service restoration.", "As shown in FIG.", "6, the signaling flow includes: Step 601: If the UE is currently in idle mode, the UE sends a service request to the MME.", "When the UE becomes active from the idle mode, step 602 is executed.", "If the UE is in active mode, step 602 is executed directly.", "Step 602: The UE sends a first MT service activation request to the MME, requesting to restore the held MT service.", "The MT service activation request may carry the ID of the MT service to be activated so that the MME can determine the MT service.", "In certain scenarios (if the UE holds only one service), the MT service ID may not be carried, which does not impact the implementation of the present invention.", "Step 603: The MME sends a second MT service activation request to the MSC.", "Step 604: After the MSC receives the second MT service activation request, the MSC matches the MT service ID with the held MT service.", "If the service exists, the MSC accepts the activation request, stops the call hold timer, allocates the requested resource, and sends a second MT service activation response to the MME.", "The second MT service activation response carries a cause value of the successful operation.", "Otherwise, the MSC rejects the activation request and sends a second MT service activation response to the MME.", "The second MT service activation response carries a cause value of the failed operation.", "In addition, if the call hold timer in the MSC expires, the MSC stops holding the MT service, releases the held resource, and stops the timer.", "Optionally, different response messages may be sent to the MME in the scenarios of success and failure.", "The response message may also carry the MT service ID to help the UE determine the MT service.", "Step 605: When the MME receives the second MT service activation response, the MME may send a first MT service activation response to the UE.", "The first MT service activation response may carry the MT service ID carried in the second MT service activation response.", "Alternatively, the MME may not send the first MT service activation response and the implementation of the present invention will not be impacted.", "Step 606: The MME sends a PS service handover request to the eNodeB.", "In practice, the MME may proceed without handing over the current PS service of the UE according to the configured network operation policy and therefore the MME does not need to send a PS service handover request to the eNodeB and the eNodeB does not need to execute the PS handover procedure.", "Step 607: The eNodeB receives the PS service handover request and initiates a PS service handover procedure to hand the UE over to the 2G/3G network.", "Step 608: After the UE is handed over to the 2G/3G network, the UE sends the first page response and completes the MT service processing.", "The above describes the CS fallback method provided in the embodiments of the present invention.", "In the CS fallback scenario, an SMS MT service may be sent to the UE via signaling of the UE in the EPS network without the need to hand over the UE to a 2G/3G network.", "For example, the first page message may carry the short message content and then the short message is sent to the UE via the EPS network.", "The UE receives the short message and completes related processing.", "Those skilled in the art may understand that all or part of the steps of the method in the above embodiments of the present invention may be implemented by hardware under instructions of a program.", "The program may be stored in a computer-readable storage medium.", "When the program is executed, the following steps are performed: by an MME, receiving an MT service indication from an MSC; sending the MT service indication to a UE; and receiving an MT service response returned by the UE and performing subsequent operations according to the MT service response.", "The storage medium may be a read-only memory, a magnetic disk or a compact disk.", "FIG.", "7 shows a CS fallback system provided in an embodiment of the present invention.", "The system includes: an MME 701, an MSC 702, and an eNodeB 703.The MSC 702 includes a service indication sending unit 7021.The service indication sending unit 7021 is configured to send an MT service indication to the MME 701 after receiving the MT service indication.", "The MME 701 provided in the embodiment of the present invention includes: a page message receiving unit 7011, configured to receive the MT service indication from the MSC 702; an MT service notifying unit 7012, configured to send the MT service indication to a UE 704; a response receiving unit 7013, configured to receive the MT service response returned by the UE 704; and a response processing unit 7014, configured to perform subsequent operations according to the MT service response.", "In practice, the MT service response carries a user choice result and the response processing unit 7014 includes: a first response processing unit, configured to return an MT service Reject message to the MSC 702 if the user chooses to reject the MT service; a second response processing unit, configured to return an MT service Hold message to the MSC 702 if the user chooses to hold the MT service; and a third response processing unit, configured to trigger the UE 704 to access a 2G/3G network if the user chooses to accept the MT service or if the user choice result is null.", "To enable the UE to restore the held MT service, the MME 701 further includes: an activation request receiving unit, configured to receive a first MT service activation request sent by the UE 704, requesting to restore the held MT service; an activation request sending unit, configured to send a second MT service activation request to the MSC 702; and an activation response receiving unit, configured to receive a second MT service activation response returned by the MSC 702 and indicates to the UE 704 that the UE 704 should access the 2G/3G network.", "The MSC 702 further includes: an activation request receiving unit, configured to receive the second MT service activation request from the MME; and an activation response sending unit, configured to return the second MT service activation response after the activation request receiving unit receives the request.", "Because some UEs are in idle mode in the EPS network, to activate the UEs, the MT service notifying unit 7012 includes: a UE activating unit, configured to activate the UE 704 via the eNodeB 703; a state querying unit, configured to: query the state of the UE 704, and trigger a sending unit if the UE 704 is in active mode, or trigger the UE activating unit if the UE 704 is in idle mode; and the sending unit, configured to send the MT service indication to the UE 704 if the UE 704 is in active mode.", "In practice, the UE activating unit has two implementations.", "In the first implementation, the unit includes: a page message sending unit, configured to send a second page message to the eNodeB 703; and a service request receiving unit, configured to trigger the MT service notifying unit 7012 after receiving the service request returned by the UE 704.In the second implementation, the UE activating unit is an activating and notifying unit.", "The activating and notifying unit is configured to send a third page message that carries an MT service indication to the eNodeB 703.By sending the third page message to the eNodeB 703, the UE is activated and the MT service indication is sent to the UE.", "An embodiment of the present invention provides an MME for processing of the SMS MT service in a CS fallback scenario.", "The MME may include: a receiving unit, configured to receive a short message from an MSC; a state judging unit, configured to judge whether a UE is in active or idle mode; a sending unit, configured to send the short message received by the receiving unit to the UE when the state judging unit determines that the UE is in active mode; an activating and sending unit, configured to activate the UE when the state judging unit determines that the UE is in idle mode and send the short message received by the receiving unit to the activated UE; and a short message response receiving unit, configured to receive a short message response from the UE.", "The activating and sending unit may include: a page sending unit, configured to send a second page message to the eNodeB; a returned message receiving unit, configured to receive a service request returned by the UE; and a short message sending unit, configured to send the short message to the UE according to the service request received by the returned message receiving unit.", "Or, the activating and sending unit may include: a page sending unit, configured to send a third page message that carries the short message to the eNodeB.", "FIG.", "7 shows the UE 704 provided in an embodiment of the present invention.", "The UE 704 includes: a notification receiving unit 7041, configured to receive the MT service indication sent by the MME 701; an notifying unit 7042, configured to notify the user of the MT service after the notification receiving unit 7041 receives the MT service indication; and a response sending unit 7043, configured to return an MT service response to the MME according to the choice of the user regarding the MT service.", "To make the held MT service restorable, the UE may further include: an activation request sending unit, configured to send a first MT service activation request to the MME, requesting to restore the held MT service.", "Further, the UE may include an MT service processing unit, configured to process the MT service.", "Although the present invention has been described through several exemplary embodiments, the invention is not limited to such embodiments.", "It is apparent that those skilled in the art can make various modifications and variations to the invention without departing from the spirit and scope of the present invention.", "The invention is intended to cover the modifications and variations provided that they fall within the scope of protection defined by the following claims or their equivalents." ] ]
Patent_15874391
[ [ "Articulating Amplifier Stand", "Improvements in a tilting, lifting stand are presented.", "The tilt, lift stand is for a musical instrument stand or to elevate/tilt a speaker and or amplifier and rigidly supports a sousaphone brass type instruments, speaker or amplifier in an in a stored and in a playable or elevated position.", "The stand supports all or the majority of the weight of the instrument or speaker or amplifier in a static position to relieve the weight of the musical instrument or speaker or amplifier.", "The stand has legs that are extendable to rest on multiple levels as might be found in a stadium.", "The stand further has a securing mechanism that gently grasps a tubular section to hold the musical instrument.", "The speaker stand can be easily collapsed for transportation and storage." ], [ "1.An articulating amplifier stand comprising: at least two sets of independently adjustable legs that are slidably connected through a central tube; a first of said at least two sets of independently adjustable legs having two legs; a second of said at least two sets of independently adjustable legs having at least one leg; at least one front supporting arm; at least one pad for supporting an amplifier or speaker, and said central tube further including a mechanical extension mechanism whereby when said mechanical extension mechanism moves a height of said supported amplifier or speaker relative to said central tube as said extension mechanism changes length.", "2.The articulating amplifier stand according to claim 1 having at least one rear supporting arm or pad to support or change an angle of said supported amplifier or speaker when said mechanical extension mechanism changes length.", "3.The articulating amplifier stand according to claim 1 wherein said first and or said second set of independently adjustable legs is slidably secured on said central tube.", "4.The articulating amplifier stand according to claim 3 wherein said first and said second set of adjustable legs having secured dovetail securing means to slidably secure said adjustable legs to said central such that said first and said second set of adjustable legs can side past each other on said central tube.", "5.The articulating amplifier stand according to claim 2 wherein said at least one rear supporting arm is adjustable.", "6.The articulating amplifier stand according to claim 5 wherein said adjustment is an angular adjustment relative to said central tube.", "7.The articulating amplifier stand according to claim 1 wherein said mechanical extension mechanism is a gas filled strut or a spring.", "8.The articulating amplifier stand according to claim 2 wherein said extension mechanism simultaneously alters an angle and a height of said amplifier or speaker relative to said first and said second sets of at least two sets of independently adjustable legs.", "9.The articulating amplifier stand according to claim 1 wherein at least one of said first and said second sets of at least two sets of independent legs alter an angle of said articulating amplifier stand.", "10.The articulating amplifier stand according to claim 1 wherein said extension mechanism is connected to a front tube that is connected to said at least one front support arm.", "11.An articulating amplifier stand comprising: at least one base member that is secured to a central tube; at least one rear supporting feature connected to said central tube; at least one front supporting arm connected to an extension tube; at least one pad for supporting an amplifier or speaker, and said central tube further including an extension mechanism whereby when said extension mechanism alters an angle of said supported amplifier or speaker relative to said at least one base member as said extension mechanism changes length.", "12.The articulating amplifier stand according to claim 11 wherein said at least one front supporting arm is adjustable.", "13.The articulating amplifier stand according to claim 12 wherein said adjustment is an angular adjustment relative to said central tube.", "14.The articulating amplifier stand according to claim 11 wherein said mechanical extension mechanism is a gas filled strut or a spring.", "15.The articulating amplifier stand according to claim 11 wherein said extension mechanism is connected to a front tube that is connected to said at least one front support arm.", "16.The articulating amplifier stand according to claim 15 wherein said front tube and said at least one front support arm translate as said extension mechanism changes length.", "17.The articulating amplifier stand according to claim 11 wherein said extension mechanism alters an angle of said amplifier or speaker relative to said at least one base member.", "18.The articulating amplifier stand according to claim 11 wherein at least one base member is a plurality of legs.", "19.The articulating amplifier stand according to claim 17 wherein said plurality of legs are securable onto said extension tube.", "20.The articulating amplifier stand according to claim 11 wherein said at least one rear supporting feature is engaged onto a rear portion of said supported amplifier or speaker, and said at least one front supporting arm engaged onto a bottom portion of said supported amplifier or speaker." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>This invention relates to improvements in an instrument, speaker and amplifier lift stand.", "More particularly, the present stand is a collapsible stand that rigidly supports instruments, speakers and amplifier.", "The lift stand also functions to elevate a speaker with the collapsible stand.", "The stand supports all or the majority of the weight of the instrument or speaker in a static position to relieve the performer or technician of the weight of the musical instrument or speaker.", "The stand can articulate an amplifier to adjust the direction of the sound or access to the controls.", "Several products and patents have been.", "Exemplary examples of patents covering these products are disclosed herein.", "Musical instrument stands are desirable for supporting various articles and instruments since they provide selective height adjustment and a stable support.", "They are particularly useful is supporting such things as cameras, video equipment, telescopes, surveying instruments, and musical instruments.", "Musical instrument stands for brass instruments, however, raise special problems when used on steps or stairs of an auditorium or stadium.", "There are several patents that describe various adjustable musical instrument stand devices.", "Bruneau U.S. Pat.", "No.", "1,517,825 shows a tripod support for a table having adjustable legs.", "This invention is an improvement over the inventor's, May, U.S. Pat.", "No.", "5,072,910.The US patent office has issued several musical instrument stands to May that disclose and provide support for musical instruments namely U.S. Pat.", "Nos.", "7,438,266, 7,588,228, 7,703,725 and 7,718,878.It is distinguished over the prior art in general, and these patents in particular by an adjustable musical instrument stand with independently adjustable legs which comprises a longitudinal extensible upright portion of telescoping tubular members, a plurality of collar members slidably mounted on the upright portion which are longitudinally adjustable relative to one another and to the upright portion for selective positioning thereon, and a plurality of movable leg members are operatively connected to upper and lower collar members for selective independent longitudinal positioning and radial extension relative to the upright portion and to one another.", "One leg of the musical instrument is adjustable in length, a sufficient amount, to permit support on two different stairs or steps of an auditorium or stadium.", "Boehm, U.S. Pat.", "No.", "3,570,130 discloses a holding device for surveying instruments which includes a channel-like mounting bracket with a pair of instrument gripping clamps and a pair of adjustable legs thereon which cooperate with the instrument to form a musical instrument type support for supporting the instrument in a reference position.", "When the upper leg supporting collar and the corresponding lower collar are moved toward each other on the upright portion, the bottom of the leg connected thereto will be extended radially outward to be positioned an unequal distance from the center of the upright portion relative to the other legs, and the upper leg supporting collar and the corresponding lower collar are moved away from each other, the bottom of the leg connected thereto will be drawn radially inward to be positioned an unequal distance from the center of the upright portion relative to the other legs.", "The one adjustable leg of the musical instrument allows the stand to be erected on multi-level surfaces.", "Various objects, features, aspects, and advantages of the present invention will become more apparent from the following detailed description of preferred embodiments of the invention, along with the accompanying drawings in which like numerals represent like components." ], [ "<SOH> BRIEF SUMMARY OF THE INVENTION <EOH>It is therefore an object of the present stand to provide an adjustable musical instrument stand that has independently adjustable movable legs.", "It is another object of this stand to provide an adjustable musical instrument stand that allows for multiple angularities and musical instrument configurations.", "Another object of this invention is to provide a stand that has two or more independently adjustable movable legs providing versatility and stability in the support system.", "Another object of this stand is to provide an adjustable musical instrument stand that allows for the body of the stand to be oriented in an off-axis position while maintaining the center of gravity in a stable support system.", "Another object of the stand is to allow collars that support the legs, to be slidably adjusted past each other to allow for a greater variety of adjustment.", "Another object of the stand is to provide an adjustable support leg positioned on the musical instrument stand and under a musical instrument to provide additional support to the musical instrument while it is being played.", "Another object of the stand is to provide a spring or gas charged strut within the musical instrument stand that assists in the extension of telescoping members.", "Another object of the stand is to provide additional extension legs that can be used in combination with the legs of the musical instrument stand to give greater extension capability for placement of the musical instrument stand on uneven surfaces.", "Another object of the stand is for the geometry of the center tube and the legs to be essentially the same to allow for part commonality and interchangeability.", "Another object of the stand is to allow the position of the leg brace to be adjustable to allow the angular arc or position of the leg to be adjusted beyond a single fixed fulcrum brace point.", "It is another object of this stand is to provide an adjustable musical instrument stand for supporting articles which is simple in construction, light-weight, economical to manufacture, rugged and reliable in use.", "It is another object of the present stand to provide an expandable musical instrument stand made from extruded sections where the extruded sections include a dovetail feature that allows the extruded tubular sections to be locked together.", "It is another object of this stand to utilize dovetail locking features to engage tubular sections and allow the stand to become longer.", "The leg section creates both the leg support and the locking mechanism for the additional tubular extension.", "It is another object of this stand to allow the overall height of the instrument stand significantly reduced make the stand easier to transport and store, the long center tube support can be split into two or more pieces and assembled using an existing leg clamp to secure the two center tube sections rigidly together.", "It is another object of this stand is to provide an adjustable tripod stand that has two or more independently adjustable movable legs providing versatility and stability in the support system.", "It is another object of this stand is to provide an adjustable tripod stand that allows for the body of the stand to be oriented in a greater off-axis position while maintaining the center of gravity in a stable support system.", "It is another object of the stand is to allow collars that support the legs, to be slidably adjusted past each other to allow for a greater variety of adjustment.", "It is another object of the stand to support an amplifier and allows the amplifier to articulate and be locked between approximately 0 degree and 45 degree positions.", "These positions allow a performer to set the amplifier at the desired angle for optimal sound and access to the amplifier controls.", "It is still another object of the stand to utilize an assisted lifting mechanism, such as a spring or gas strut, to make adjusting the height of the playing surface of the musical instrument easier.", "The assisted lifting mechanism allows for an infinite number of heights that the instrument can be adjusted and the adjustment can be made quickly by a performer.", "Various lifting mechanisms can be used based upon the required force and the amount of extension that is required.", "Various objects, features, aspects, and advantages of the present invention will become more apparent from the following detailed description of preferred embodiments of the invention, along with the accompanying drawings in which like numerals represent like components." ], [ "CROSS REFERENCE TO RELATED APPLICATION This application is a continuation of U.S. patent application Ser.", "No.", "15/169,147, filed May 31, 2016, which is a continuation of U.S. patent application Ser.", "No.", "14/598,162, filed on Jan. 15, 2015, now U.S. Pat.", "No.", "9,377,158, which claims priority to provisional application 61/927,863 filed on Jan. 15, 2014, the entire contents of which is hereby expressly incorporated by reference herein.", "BACKGROUND OF THE INVENTION This invention relates to improvements in an instrument, speaker and amplifier lift stand.", "More particularly, the present stand is a collapsible stand that rigidly supports instruments, speakers and amplifier.", "The lift stand also functions to elevate a speaker with the collapsible stand.", "The stand supports all or the majority of the weight of the instrument or speaker in a static position to relieve the performer or technician of the weight of the musical instrument or speaker.", "The stand can articulate an amplifier to adjust the direction of the sound or access to the controls.", "Several products and patents have been.", "Exemplary examples of patents covering these products are disclosed herein.", "Musical instrument stands are desirable for supporting various articles and instruments since they provide selective height adjustment and a stable support.", "They are particularly useful is supporting such things as cameras, video equipment, telescopes, surveying instruments, and musical instruments.", "Musical instrument stands for brass instruments, however, raise special problems when used on steps or stairs of an auditorium or stadium.", "There are several patents that describe various adjustable musical instrument stand devices.", "Bruneau U.S. Pat.", "No.", "1,517,825 shows a tripod support for a table having adjustable legs.", "This invention is an improvement over the inventor's, May, U.S. Pat.", "No.", "5,072,910.The US patent office has issued several musical instrument stands to May that disclose and provide support for musical instruments namely U.S. Pat.", "Nos.", "7,438,266, 7,588,228, 7,703,725 and 7,718,878.It is distinguished over the prior art in general, and these patents in particular by an adjustable musical instrument stand with independently adjustable legs which comprises a longitudinal extensible upright portion of telescoping tubular members, a plurality of collar members slidably mounted on the upright portion which are longitudinally adjustable relative to one another and to the upright portion for selective positioning thereon, and a plurality of movable leg members are operatively connected to upper and lower collar members for selective independent longitudinal positioning and radial extension relative to the upright portion and to one another.", "One leg of the musical instrument is adjustable in length, a sufficient amount, to permit support on two different stairs or steps of an auditorium or stadium.", "Boehm, U.S. Pat.", "No.", "3,570,130 discloses a holding device for surveying instruments which includes a channel-like mounting bracket with a pair of instrument gripping clamps and a pair of adjustable legs thereon which cooperate with the instrument to form a musical instrument type support for supporting the instrument in a reference position.", "When the upper leg supporting collar and the corresponding lower collar are moved toward each other on the upright portion, the bottom of the leg connected thereto will be extended radially outward to be positioned an unequal distance from the center of the upright portion relative to the other legs, and the upper leg supporting collar and the corresponding lower collar are moved away from each other, the bottom of the leg connected thereto will be drawn radially inward to be positioned an unequal distance from the center of the upright portion relative to the other legs.", "The one adjustable leg of the musical instrument allows the stand to be erected on multi-level surfaces.", "Various objects, features, aspects, and advantages of the present invention will become more apparent from the following detailed description of preferred embodiments of the invention, along with the accompanying drawings in which like numerals represent like components.", "BRIEF SUMMARY OF THE INVENTION It is therefore an object of the present stand to provide an adjustable musical instrument stand that has independently adjustable movable legs.", "It is another object of this stand to provide an adjustable musical instrument stand that allows for multiple angularities and musical instrument configurations.", "Another object of this invention is to provide a stand that has two or more independently adjustable movable legs providing versatility and stability in the support system.", "Another object of this stand is to provide an adjustable musical instrument stand that allows for the body of the stand to be oriented in an off-axis position while maintaining the center of gravity in a stable support system.", "Another object of the stand is to allow collars that support the legs, to be slidably adjusted past each other to allow for a greater variety of adjustment.", "Another object of the stand is to provide an adjustable support leg positioned on the musical instrument stand and under a musical instrument to provide additional support to the musical instrument while it is being played.", "Another object of the stand is to provide a spring or gas charged strut within the musical instrument stand that assists in the extension of telescoping members.", "Another object of the stand is to provide additional extension legs that can be used in combination with the legs of the musical instrument stand to give greater extension capability for placement of the musical instrument stand on uneven surfaces.", "Another object of the stand is for the geometry of the center tube and the legs to be essentially the same to allow for part commonality and interchangeability.", "Another object of the stand is to allow the position of the leg brace to be adjustable to allow the angular arc or position of the leg to be adjusted beyond a single fixed fulcrum brace point.", "It is another object of this stand is to provide an adjustable musical instrument stand for supporting articles which is simple in construction, light-weight, economical to manufacture, rugged and reliable in use.", "It is another object of the present stand to provide an expandable musical instrument stand made from extruded sections where the extruded sections include a dovetail feature that allows the extruded tubular sections to be locked together.", "It is another object of this stand to utilize dovetail locking features to engage tubular sections and allow the stand to become longer.", "The leg section creates both the leg support and the locking mechanism for the additional tubular extension.", "It is another object of this stand to allow the overall height of the instrument stand significantly reduced make the stand easier to transport and store, the long center tube support can be split into two or more pieces and assembled using an existing leg clamp to secure the two center tube sections rigidly together.", "It is another object of this stand is to provide an adjustable tripod stand that has two or more independently adjustable movable legs providing versatility and stability in the support system.", "It is another object of this stand is to provide an adjustable tripod stand that allows for the body of the stand to be oriented in a greater off-axis position while maintaining the center of gravity in a stable support system.", "It is another object of the stand is to allow collars that support the legs, to be slidably adjusted past each other to allow for a greater variety of adjustment.", "It is another object of the stand to support an amplifier and allows the amplifier to articulate and be locked between approximately 0 degree and 45 degree positions.", "These positions allow a performer to set the amplifier at the desired angle for optimal sound and access to the amplifier controls.", "It is still another object of the stand to utilize an assisted lifting mechanism, such as a spring or gas strut, to make adjusting the height of the playing surface of the musical instrument easier.", "The assisted lifting mechanism allows for an infinite number of heights that the instrument can be adjusted and the adjustment can be made quickly by a performer.", "Various lifting mechanisms can be used based upon the required force and the amount of extension that is required.", "Various objects, features, aspects, and advantages of the present invention will become more apparent from the following detailed description of preferred embodiments of the invention, along with the accompanying drawings in which like numerals represent like components.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWING(S) FIG.", "1 shows a back isometric view of the sousaphone stand on a stadium stand supporting a sousaphone.", "FIG.", "2 shows a front perspective view of a tuba mounted in the stadium stand.", "FIG.", "3 shows a front perspective view of the sousaphone stand on a stadium stand supporting a sousaphone.", "FIG.", "4 shows a side perspective view of the sousaphone stand.", "FIG.", "5 shows a tubular clamp in an open configuration.", "FIG.", "6 shows the tubular clamp from FIG.", "4 receiving a tube.", "FIG.", "7 shows a perspective view of the tubular clamp from FIGS.", "4 and 5 grasping a tube.", "FIG.", "8 shows a top perspective view of the sousaphone stand.", "FIG.", "9 shows the collapsed pieces of the sousaphone stand ready for transportation.", "FIG.", "10 is an exploded view of the extension mechanism.", "FIG.", "11 is an exploded view of the clamping mechanism for the extension lift mechanism.", "FIG.", "12 is an isometric view of the extendable tripod stand with a vertically mounted bass drum.", "FIG.", "13 shows a top perspective view of a compound lift mechanism.", "FIG.", "14 shows a detailed view of a compound lift mechanism.", "FIG.", "15 shows a perspective view of the compound lift in a retracted condition with a top mounted speaker.", "FIG.", "16 shows a perspective view of the compound lift in an extended condition with a top mounted speaker.", "FIG.", "17 shows an elevated front view of the amplifier stand.", "FIG.", "18 shows an upper front perspective view of the amplifier stand.", "FIG.", "19 shows a side view of the amplifier stand at an approximately 0 degree angle.", "FIG.", "20 shows a side view of the amplifier stand at an approximately 45 degree angle.", "FIG.", "21 shows a view of the amplifier stand in a collapsed configuration.", "DETAILED DESCRIPTION OF THE INVENTION FIG.", "1 shows a back isometric view of the sousaphone stand on a stadium stand supporting a sousaphone.", "FIG.", "2 shows a front perspective view of a tuba mounted in the stadium stand.", "FIG.", "3 shows a front perspective view of the sousaphone stand on a stadium stand supporting a sousaphone and FIG.", "4 shows a side perspective view of the sousaphone stand.", "From FIG.", "1 a sousaphone 10 is shown resting upon the stand.", "The stand has two sets of legs, 30, 31 and 40, 41 that are configured to slide on a central tube 20.The two sets of legs are independently connected to the central tube 20 to allow the legs to be placed on different elevations whereby allowing the first set of legs 30, 31 to be placed on the ground and the second set of legs to be placed on a bench seat 11 or similar raised platform that might be found in a stadium.", "While in some of the figures the legs are shown at different elevations they may also be placed on the same elevation or slightly offset in elevation to prone the stand in an off axis orientation.", "The sousaphone is placed on the stand where the upper curved tube of the sousaphone 10 rests in the cradle of the arc sector or “V” receivers 60 and 61 that are covered with padding 62 to cushion the sousaphone 10.The padding can be a variety of different materials including but not limited to felt, cloth, rubbers, plastics or elastomeric.", "The arc padded sectors 60 and 61 are connected to a head 21 with arms 63 and 64.While arc sector or “V” receivers are shown in FIGS.", "1 to 3, the head may be replaced with an elbow 73 that is connected to a single clamp as shown and described in FIGS.", "4 to 5.The cantilevered weight of the sousaphone 10 naturally rotates the sousaphone 10 in the arc sector or “V” receivers 60 and 61 such that the lower portion of the sousaphone 10 rests on pads 50 and 51.The pads 50 and 51 are pivotable on pivot pads 52 and 53 and can slide 54 on a second set of legs 40 and 41 to allow the pads 50 and 51 to be placed at a location that provides protection of the instrument.", "The pivoting and sliding of the pads 52 and 53 allows for player customization to accommodate placement of the pads 52 and 53.The first set of legs 30 and 31 are slidably connected to the central tube 20 with two independent dovetail tubular first upper collar slider 32 and first lower collar slider 33.The first upper collar slider 32 is pivotably 35 connected to one end of each leg 30 and 31, while the first lower collar slider 33 is pivotably 35 connected to leg brace(s) 34 that are then slidably 38 and pivotably 35 connected to an opposing end of each leg 30 and 31.A tension screw 36 on each first upper and lower collar slider 32 and 33 secures each slider on the central tube 20.The lower end of each leg 30 and 31 has a foot pad 37 to protect the surface where the stand is placed upon.", "The second set of legs 40 and 41 are slidably connected to the central tube 20 with two independent dovetail tubular second upper collar slider 42 and second lower collar slider 43.The second upper collar slider 42 is pivotably 45 connected to one end of each leg 40 and 41, while the second lower collar slider 43 is pivotably 45 connected to leg brace(s) 44 that are then slidably 48 and pivotably 45 connected to an opposing end of each leg 40 and 41 .", "A tension screw 46 on each first upper and lower collar slider 42 and 43 secures each slider on the central tube 20.The lower end of each leg 40 and 41 has a foot pad 47 to protect the surface where the stand is placed upon.", "The collar sliders 32, 33, 38, 42, 43, and 48 are configured with reverse facing dovetail edges having a wrap angle of less than 180 degrees of wrap on the central tube and the legs 30, 31 , 40 and 41 that allows the collar sliders to slide past each other on the central tube 20 and or the legs 30, 31 , 40 and 41.In addition, because both the upper and lower collar sliders are independent, the angle of the leg 32, 33, 42 and 43 and or leg more brace(s) 34 and 44 are adjustable to alter the distance between the foot pads 37, 47 and the central tube 20.The central tube 20 has an internal extension tube 70 that can be adjusted in extension to raise or lower the height of the arc sector or “V” receiver 60, 61 pads 62.The extension tube 70 can further be removed, as shown in FIG.", "9, for storage or transportation.", "The extension tube is securable in position on the central tube 20 with a tube clamp 69 that operates with a cam 72 on a lever to allow for quick clamping and releasing of the extension tube 70.In FIG.", "2, the bottom of the tuba 14 is placed onto the arc sector or “V” receivers 60 and the tube of the tuba 14 is secured in clamp 80.FIGS.", "5 to 7 show and describe the clamp in greater detail.", "FIG.", "5 shows a tubular clamp in an open configuration, FIG.", "6 shows the tubular clamp 80 from FIG.", "4 receiving a tube and FIG.", "7 shows a perspective view of the tubular clamp 80 from FIGS.", "4 and 5 grasping a tube.", "This clamp 80 can be placed on the extension tube 70 to grasp the tube 12 of a musical instrument.", "The riser tube 75 is held with elbow 73 in position on the instrument stand.", "The position of the tubular clamp on the stand is adjustable and secured with screw clamp 92.The tubular clamp 80 has a first arc sector or “V” receiver 81 and a second arc sector or “V” receiver 82 that grasps at least partially around the tube 12 of a musical instrument.", "The first arc sector or “V” receiver 81 pivots on a pivot axis 83 while the second arc sector or “V” receiver 82 pivots on a pivot axis 84 that extends through the body 91 of the tubular clamp 80.The inside edges 93 limits the amount that the arc sector or “V” receivers will open.", "Each arc sector or “V” receiver 81 and 82 is padded or cushioned 86 to both frictionally grip the instrument tube 12 and to prevent damage to the instrument tube 12.When the instrument tube is pushed into the tubular clap 80 the arc sector or “V” receivers 81 and 82 will pivot until holes 89 engage into pins 88 that will hold the arc sector or “V” receivers 81 and 82 in a closed orientation as shown in FIG.", "7.When release 85 is pulled back 87 the pins 88 will be pulled out of retentions holes 89 whereby releasing the arc sector or “V” receivers 81 and 82 and spring 94 will pull 90 the arc sector or “V” receivers 81 and 82 open to release the tube 12.FIG.", "8 shows a top perspective view of the sousaphone stand that is shown in FIGS.", "1-4.This orientation of the stand represents the orientation where a performer will place the sousaphone into the stand.", "Because of the weight and cost of a sousaphone performers must often support the weight of the instrument by placing the instrument on their legs as they rest on the stadium.", "Using this instrument stand, a performer can place the instrument stand in a stadium and adjust the height of legs 30, 31 and 40, 41 to accommodate the geometry of the stadium seat or bleacher.", "The performer will loosen the cam clamp 72 to raise or lower the extension tube 70 from the central tube 20 and then tighten the tube clamp.", "The performer will then rest the upper tube of the sousaphone in the pads 62 of the arc sector or “V” receivers 60 and 61 that exist on the ends of arms 63, 64 from head 21.The sousaphone will then naturally rotate onto pads 50 and 51 that can also be adjustable on legs 30 and 31 to cushion the sousaphone.", "It is contemplated that to assist in positioning the extension tube 70 that a spring, gas filled strut or other similar lifting mechanism are can be incorporated into the central tube 20 to assist a performer to extend the extension tube 70 out of the center tube 20 as shown and described in FIG.", "10.FIG.", "9 shows the collapsed pieces of the sousaphone stand ready for transportation.", "In this figure the central tube 20 including the cam clamp 72, extension tube 70, head 21 and the padded arc sector or “V” receiver musical instrument supports are separated from the leg assemblies.", "The leg assemblies will include the first leg set 30, 31, sliders and foot pads 37.The leg assemblies also include the second leg set that are partially visible behind the first leg set 30, 31.The pads 50 and 51 are shown rotated against the pivoting sliders to minimize storage size.", "The slide collar 42 is shown removed from the central tube 20.While FIG.", "9 shows the sousaphone stand, the tuba stand is disassembled in a similar manner.", "Referring now to FIG.", "10 that shows an exploded view of the extension mechanism 39.The extension/lift mechanism can be a variety of different mechanism.", "In FIG.", "6 it is shown as a compression spring.", "In this figure the lift/extension mechanism is shown and described as a strut.", "The strut shown is a gas filled extension mechanism that naturally exists in an extended orientation.", "Pushing upon the two ends will compress the strut.", "Various different forces and extension lengths are available.", "When using the strut in the embodiments shown, the strut must be stopped med stroke at the length desired by the user.", "One contemplated embodiment of the clamping mechanism is shown and described in FIG.", "12.The strut 39 has end caps 53 and 55 that are installed with the tubes 34 and 26.A set screw or stops 51 and 58 retain the end caps 53 and 55 within the tubes 34 and 26.In one embodiment the end caps sit on the screws 51 and 58.In another embodiment the screws 51 and 58 bind the end caps 53 and 55 to prevent the inner tube 34 from being accidentally removed from the outer tube 26.A guide 54 exists in the middle of the strut 39 to reduce axial loading on the strut that could harm the seals of the strut 39.The extension mechanism can be either inserted into the inner tube 34 or in the outer tube 26.A securing means for securing a musical instrument is attached to the end of the upper tube 34.The instrument securing means allows a performer to install a musical instrument such as a drum or other musical instrument onto the stand.", "Various types of percussion musical instruments are shown in the figures.", "In this figure the securing means is a saddle 62 where a musical instrument is placed vertically into the securing means 60.FIG.", "11 is an exploded view of the clamping mechanism 69.Referring briefly to FIGS.", "1, 3, 4, 8 and 9 the clamping mechanism 69 is shown where the lower tube 26 and the upper tube 34 intersect.", "The clamping mechanism is an extrusion 60 with a central hole 62 where the lower portion of the clamping mechanism 69 is secured to the lower or outer diameter tube 26.The clamping mechanism is partially split into a lower portion that is secured to the lower tube 26 (not shown) and an upper section that can temporally hold the upper tube 34 (not shown) the split 63 separates these two section and allows separate flexibility for clamping the upper and lower parts of the clamping mechanism 69.A screw 64 closes the lower portion of the clamping mechanism 69 on the lower tube.", "A separate screw 65 passes through the upper portion of the clamping mechanism 69 where it is threaded into as shoulder bolt 67 with a threaded hole that the screw 65 threads into.", "A nut 68 retains the shoulder bolt 67 on a cam arm.", "The cam arm 66 has an eccentric hole that allows the upper portion of the clamping apparatus/griping means to close the gap 61 onto an upper tube to prevent extension of the upper tube 34 (not shown).", "In FIG.", "12 the extendable stand is mounted with a vertically mounted on a bass drum.", "In each of the configurations the drum can be quickly removed from a performer's body mounted carrier and installed onto the adjustable stand.", "In all of these configurations the base or legs 23 extend from the lower central tube 26.The extension mechanism exists inside one of the tubes where it is secured or located with screws 58 and or 51.In all of these figures the upper tube 34 is shown partially pushed out of the lower tube 26.The amount of extension of the upper tube 34 out of the lower tube 26 is determined by the performer preference and an infinite number of different heights are adjustable.", "The force and extension length of the extension mechanism is variable based upon the type and weight of instrument that is being supported.", "In the preferred embodiment the force of the extension mechanism is selected to allow for minimal force by the user to raise or lower the musical instrument 79 and the weight of the musical instrument is sufficient to approximately equal the force from the extension mechanism.", "The strut can be fixed to the stand, or can be changeable.", "The clamping apparatus/griping means 69 grips the upper tube to prevent undesirable movement of the upper tube 70 while a performer is performing.", "The location of the tube 70 is quickly adjustable with the eccentric cam arm 66.A securing means for securing a musical instrument 81 is attached to the end of the upper tube 70.The instrument securing means 81 allows a performer to install a musical instrument 81 such as a drum or other musical instrument onto the stand.", "In some cases a support brace or bracket 71 is used to reduce the moment arm of the musical instrument on the stand.", "In the figures a further support arm 71 extends from the brace or bracket 70 to the drums 81 that is mounted.", "The inventor of this disclosure has also been awarded U.S. Pat.", "Nos.", "7,438,266, 7,588,228, 7,703,725 and 7,718,878 that may disclose tripod type stands.", "It is distinguished over the prior art in general, and these patents in particular by an adjustable musical instrument stand with independently adjustable legs 23 which comprises a longitudinal extensible upright portion 26 of telescoping tubular members, a plurality of collar members 69 slidably mounted on the upright portion 26 which are longitudinally adjustable relative to one another and to the upright portion 26 for selective positioning.", "The lift mechanism further creates additional improvement and user performance features that were not obvious and are novel over the inventors' prior patents.", "FIG.", "13 shows a top perspective view of a compound lift mechanism, FIG.", "14 shows a detailed view of a compound lift mechanism, FIG.", "15 shows a perspective view of the compound lift in a retracted condition with a top mounted speaker, and FIG.", "16 shows a perspective view of the compound lift in an extended condition with a top mounted speaker.", "In FIGS.", "13 and 14 a second or compound lift member 76 is mounted aside the lower central tube 26.The parallel structure of the lower central tube with the compound lift member 76 provides additional stability when the parallel members are clamped.", "Releasing the lower clamping mechanism 69 allows the internal extension/lift mechanism rod 98, as shown and described in FIG.", "10, pushes upon connecting elbow 73 to extend as the guides 54 slide along the outrigger lift tube 76.A second extension/lift mechanism 70 is exists within the outrigger lift tube 76 to provide a second lift to further extend the lift height of the stand by releasing upper clamping mechanism 74.In FIG.", "15 a speaker 99 is mounted to the top of the stand and shown in a lowered condition.", "In FIG.", "16 one of the legs 23 is shown slightly displaced to show an adjustment for placement of the stand on an uneven surface.", "FIG.", "16 also shows the speaker more fully elevated with both the first stage extension tube 98 and the second stage extension tube 70 released and extended.", "Once the tubes are extended to the desired extension, clamps 68 and 74 are secured.", "These clamps 68 and 74 are shown and described in more detail with FIG.", "11 herein.", "FIG.", "17 shows an elevated front view of the amplifier stand, and FIG.", "18 shows an upper front perspective view of the amplifier stand.", "The base of the amplifier stand is essentially the same four legged structure shown and described in the previous figures where there are two front supporting legs 30, 31 and two separate supporting legs 40, 41.The legs are supported through sliding supporting brackets 35, 38 and support arms 34, 44.The legs slide and are supported on a rear central tube 119 that is connected to a front tube 120.In addition to the supporting legs, two supporting arms are pivotable connected 111, 121 to the stand.", "The right arm, sections 112 and 114 are connected 111 on one side while left arm sections 122 and 124 are connected 121 on the opposing side of the rear central front tube 119.The ends of the arms 115 and 125 contact and support the rear of the amplifier 100.The length of the arms are individually adjustable with locking members 113 and 123.The bottom of the amplifier 100 is supported on pads 56 that extend from arms 57 and connector 59 that is supported on the front tube 120.A mechanical lift or extension mechanism is located within the rear central tube 119.The height of the pivoting location 111 and 112 of the left 122/124 and right arm 112/114 sections is essentially fixed, based upon the height of the collar 118.The tube 98 extends from the collar 118 position.", "As the lift mechanism lifts the tube 98 the head 110 is also moved along with the front tube that moves the supporting pads 56.As the supporting pads 56 are raised, the position of the pads 56, relative to the fixed position of the collar 118, forces the amplifier 100 to rotate from an initial 0 degree to a final approximately 45 degree position.", "The amplifier 100 can be stopped at any desired position between 0 and 45 degrees.", "While 0 and 45 degrees are specifically identified in this disclosure, greater and lesser angles are contemplated.", "This articulation is shows and described in more detail in other figures shown in this disclosure.", "The back of the speaker can rest on a rear supporting feature 117 where the speaker is supported on the supporting pads 56 and on the rear supporting feature 117 that can be a pad or cushion that lifts with the front tube 120.The angle of the speaker is altered by changing the position of the legs on the central tube 119.FIG.", "19 shows a side view of the amplifier stand at an approximately 0 degree angle and FIG.", "20 shows a side view of the amplifier stand at an approximately 45 degree angle.", "From these two figures it is shown that as the tube 98 extends the lift from the bottom of the amplifier 100 causes the (fixed length) arms 112, 114 to pivot at 111 on slider 116 to alter the angle of the amplifier 100 on the stand.", "FIG.", "21 shows a view of the amplifier stand in a collapsed configuration to allow the stand to be stored or transported in a smaller configuration.", "Essentially the legs and supports arms fold inward thereby providing a smaller packaged size.", "Thus, specific embodiments of a stand have been disclosed.", "It should be apparent, however, to those skilled in the art that many more modifications besides those described are possible without departing from the inventive concepts herein.", "The inventive subject matter, therefore, is not to be restricted except in the spirit of the appended claims." ] ]
Patent_15874394
[ [ "DERIVING PERSONALIZED EXPERIENCES OF SMART ENVIRONMENTS", "A method for obtaining a representation of an environment includes requesting device context information from a user device.", "The request is sent to the user device from a virtual machine environment established by a database processor.", "The virtual machine environment is established by the database processor in response to a request received from the user device over a network for a representation of an environment.", "User preference information is requested and the device context information and the user preference information are received in the virtual machine environment.", "Based on the device context information, an environmental data set (EDS) is identified that includes information reflective of the environment.", "The EDS is received in the virtual machine environment and the EDS is modified based at least in part on the user preference information.", "Executable computer code is constructed for generating a representation from the modified EDS and sent to the user device." ], [ "1.A method of obtaining a representation of an environment, comprising: requesting device context information from a user communications device associated with a user, the request being sent to the user communications device from a virtual machine environment established by a database processor, the virtual machine environment being established by the database processor in response to a request received from the user communications device over a communications network for a representation of an environment associated with a third party; requesting user preference information; receiving in the virtual machine environment the device context information and the user preference information; based at least in part on the device context information, identifying at least one EDS that is associated with the environment and includes information reflective of the environment; receiving the at least one EDS in the virtual machine environment; while in the virtual machine environment, modifying the at least one EDS based at least in part on the user preference information; constructing executable computer code for generating a representation from the modified EDS; and causing the executable code to be sent to the user communications device.", "2.The method of claim 1, wherein the request from the user communications device is received by a website from a web browser of the user communication device, the user communications device being re-directed from the website to the database processor.", "3.The method of claim 1, wherein modifying the at least one EDS includes supplementing the EDS with additional information based on the user preference information.", "4.The method of claim 1, wherein modifying the at least one EDS includes filtering the EDS to remove selected information therein based on the user preference information.", "5.The method of claim 1, wherein modifying the at least one EDS includes supplementing the EDS with additional information based on the user preference information and filtering the EDS to remove selected information therein.", "6.The method of claim 1, herein the at least one EDS includes a plurality of EDSs and further comprising merging the plurality of EDSs.", "7.The method of claim 1, wherein identifying the at least one EDS includes discovering executable code stored in a searchable database by matching the device context information with attributes of the executable code, the at least one EDS being identified by one of the attributes of the executable code that are discovered, the executable code being extracted from web resources and stored in the searchable database.", "8.The method of claim 7, wherein constructing the executable computer code includes obtaining at least a portion of the executable computer code from the discovered executable code.", "9.The method of claim 1, wherein requesting and receiving the user preference information includes requesting and receiving the user preference information from the user communications device.", "10.The method of claim 1, wherein receiving the user preference information includes receiving a verifiable cryptographic credential that encapsulates the user preference information without exposing an identity of the user.", "11.The method of claim 10, wherein the cryptographic credential is received in the VM from an entity other than the user communications device.", "12.The method of claim 1, wherein the device context information includes geographic and calendar information associated with the user communications device." ], [ "<SOH> BACKGROUND <EOH>Personalization is a major component in Internet applications and services.", "Web pages are often customized to user preferences.", "Content on web pages may be chosen to conform to preferences of users.", "Advertisements are targeted to particular users.", "Apps provide customized services based on user profiles and user provided data.", "Personalization has been a central component of Internet services for more than a decade." ], [ "<SOH> SUMMARY <EOH>In accordance with one aspect of the subject matter described herein, a system and method is presented for obtaining a representation of an environment.", "In accordance with the method, device context information is requested from a user communications device associated with a user.", "The request is sent to the user communication device from a virtual machine environment established by a database processor.", "The virtual machine environment is established by the database processor in response to a request received from the user communications device over a communications network for a representation of an environment associated with a third party.", "User preference information is requested and the device context information and the user preference information are received in the virtual machine environment.", "Based at least in part on the device context information, at least one environmental data set (EDS) is identified that is associated with the environment and includes information reflective of the environment.", "The EDS is received in the virtual machine environment and, while in the virtual machine environment, the EDS is modified based at least in part on the user preference information.", "Executable computer code is constructed for generating a representation from the modified EDS.", "The executable code is caused to be sent to the user communications device." ], [ "CROSS-REFERENCE This application claims priority to U.S.", "Provisional Application Ser.", "No.", "62/447,802, filed Jan. 18, 2017.This application is also a continuation-in-part of U.S. application Ser.", "No.", "15/475,748, filed Mar.", "31, 2017 entitled “System and Method for Sharing and Trading User Data and Preferences Between Computer Programs and Other Entities While Preserving User Privacy”, a continuation-in-part of U.S. Ser.", "No.", "14/466,676, filed Aug. 22, 2014, entitled “Method and System for Addressing the problem of Discovering Relevant Services and Applications that are available over the Internet and other Communications Networks”, and a continuation-in-part of U.S. application Ser.", "No.", "14/701,858, filed May 1, 2015 entitled “A System and Method for Mediating Representations with Respect to User Preferences”, the contents of which are incorporated herein by reference.", "BACKGROUND Personalization is a major component in Internet applications and services.", "Web pages are often customized to user preferences.", "Content on web pages may be chosen to conform to preferences of users.", "Advertisements are targeted to particular users.", "Apps provide customized services based on user profiles and user provided data.", "Personalization has been a central component of Internet services for more than a decade.", "SUMMARY In accordance with one aspect of the subject matter described herein, a system and method is presented for obtaining a representation of an environment.", "In accordance with the method, device context information is requested from a user communications device associated with a user.", "The request is sent to the user communication device from a virtual machine environment established by a database processor.", "The virtual machine environment is established by the database processor in response to a request received from the user communications device over a communications network for a representation of an environment associated with a third party.", "User preference information is requested and the device context information and the user preference information are received in the virtual machine environment.", "Based at least in part on the device context information, at least one environmental data set (EDS) is identified that is associated with the environment and includes information reflective of the environment.", "The EDS is received in the virtual machine environment and, while in the virtual machine environment, the EDS is modified based at least in part on the user preference information.", "Executable computer code is constructed for generating a representation from the modified EDS.", "The executable code is caused to be sent to the user communications device.", "BRIEF DESCRIPTIONS OF THE DRAWINGS FIG.", "1 shows an exemplary snippet database.", "FIG.", "2 defines exemplary attributes that may be included in a snippet database.", "FIG.", "3 shows one exemplary system architecture for implementing aspects of the methods and techniques described herein.", "FIG.", "4 illustrates one example of a method for generating a single representation of an environment.", "FIG.", "5 shows another example of a method for generating a representation of an environment.", "FIG.", "6 shows an example architecture for a device such as the user communication devices or database complex shown in FIG.", "3 DETAILED DESCRIPTION Introduction Personalization of services is a basic aspect of Internet and web services.", "Content and web pages are constructed dynamically to suit the preferences and tastes of consumers.", "Advertisements are tailored to specific users.", "The systems and techniques described herein may be applied to personalize, e.g., geographical, environments such as smart homes, retail stores, shopping malls, smart cars, etc.", "In particular, two kinds of personalization are envisioned that may be described as follows.", "In a first kind of personalization, environments are personalized by creating datasets called representations (also referred herein as experiences) of an environment, e.g., a geographical environment, that are tailored to specific preferences of a single user.", "These representations may then be delivered, e.g., to the user's communications device.", "In a second kind of personalization, environments are personalized by creating representations of an environment, e.g., a geographical environment, that are tailored to groups of users.", "These representations may then be delivered to the respective communications devices of the group members or rendered on one or more common devices in the environment, e.g., within the confines of a retail store or smart car using Internet connected devices available to all customers of the store or all the occupants of the car.", "Illustrative Embodiments We present two illustrative embodiments to demonstrate aspects of the present invention.", "However, these and other such exemplary embodiments described later do not limit the scope of the present invention in any manner, which is to be determined by the claims attached herein.", "In a first embodiment, we consider a smart car traversing a route along which one or more retail stores are located.", "The occupants of the car are interested in knowing if the retail stores carry products that are of interest to them.", "That is, the occupants may wish to search the store inventories with respect to their preferences.", "As the smart car traverses, say, a street, the inventories of the stores on the street are searched and “relevant” items of interest may be displayed on the user communications devices of the occupants.", "A data object would thus be delivered to each occupant that when rendered on his communications device may display items of interest to him in the nearby store.", "As the car continues to move, the display changes to the next nearby store along the route of the car.", "Note that the route of the car may be pre-determined by navigation software.", "In a certain sense, this example illustrates a different notion of “points of interest” (POI) that are commonly provided by many navigation software systems.", "In a second embodiment, consider the case that the smart car has a single display device for all the occupants of the car and we are now interested in displaying the items of interest that may appeal to all the occupants.", "That is, we are interested in “aggregating” the preferences of all the occupants with respect to the inventories of the nearby stores and display the result on the display device of the car.", "Note that in this use case, we are interested in catering to the preferences of all occupants of the car, not any single occupant.", "Other use cases readily follow, as for example, a retail store that wishes to play background music in the store for all its customers.", "Alternatively, the store may wish to set the overall temperature of the store so that it is comfortable for all the customers currently visiting the store at a given time.", "The following elements are significant in the above two exemplary illustrative embodiments.", "They will be explained in greater detail below.", "1.The notion of datasets representing the inventories of the environments (e.g., business premises such as retail stores, smart homes, etc.)", "2.The notion of “nearby” implying a relationship between computer programs (e.g., the computer program that determines items of interest, or the program that searches the inventory dataset) and geography (e.g., the location of the store and/or the car).", "3.The notion of user “preferences” that guides the searching of the various datasets.", "4.The notion of “aggregating” preferences so as to satisfy multiple users.", "5.Management of preferences whilst maintaining privacy of the users.", "6.The ability of users to receive information about items of interest without using a priori downloaded apps and/or opt-in mechanisms.", "Technological Innovations The systems and techniques described herein offer a number of improvements to the technology of database systems, app stores and to the general functioning and utility of apps.", "With respect to improvements to general functioning and utility of apps, it is widely known that apps need to be downloaded prior to their use by a consumer.", "Thus, consumers have to discover an app, download it and prepare to use it later, e.g., by establishing an account with the app provider.", "In many situations, a consumer may wish to run more than one app.", "For example, consider the first exemplary embodiment above.", "An occupant of the car wishing to search nearby stores (as the car traverses its route) needs to acquire and then run the app of each nearby store.", "This would require a succession of apps to have been downloaded a priori, set up for later use and then launched manually by each occupant of the car.", "There may thus be a need for a sequence of manual operations expected of each occupant of the car.", "In one aspect, the systems and techniques described herein introduce the notion of executable codes running in a remote computing environment that serve the needs of consumers in an environment such as a smart car, a smart home or other business premises such as a shopping mall, etc.", "Since the customers of a store or the occupants of a car may wish to search the inventory of the stores with respect to user preferences, these preferences need to be communicated to the respective apps.", "This introduces a possible additional manual step.", "It may, however, be obviated if the user preferences were to be available to the, e.g., operating system, of the user communication device that may then provide the user preferences to the apps on the user device that need the preferences (or to the executable codes in the remote computing environment).", "The systems and techniques described herein avoid the need for this manual step and, moreover, may accomplish the communication of user preferences in a privacy preserving manner.", "A database system along with a database processor, i.e., a special computer program, may be constructed so as to associate special-purpose executable codes with device context, geographic context and calendar (e.g., date and time) context in a manner that the executable codes are discoverable and operable when a request from a user communications device is received, provided the user communications device satisfies the device, geographical and calendar contexts.", "Additionally, a proposed route may be provided as a part of the incoming request to the database processor that may then identify “relevant” executable codes based on the geographical and calendar contexts that lie along the proposed route.", "Thus, the database processor may construct a sequence of operations in which the executable codes may be executed in synchronization with the proposed route being traversed by the user communication device.", "It is to be noted that the database processor is not to be confused with a conventional geographical database system, i.e., a database system that stores information about geographical locations or objects described by their locations.", "In our case, the database processor has access to a database system that stores executable codes.", "The latter are associated with geographic locations in such a manner that they become discoverable and operable when incoming requests satisfy the contextual constraints imposed on the executable codes.", "The database processor further provides an execution environment wherein discovered executable codes may be executed (with respect to user preferences) and the results of their executions provided to one or more user devices.", "Thus, the proposed database processor has the following characteristics.", "1.It has access to a store of executable codes.", "2.It associates stored executable codes with device, geographical and calendar contexts.", "3.It makes the executable codes discoverable and operable when the contexts are satisfied by a user communications device making an incoming request.", "4.In response to requests from a user communications device, it constructs an operating environment in which discovered executable codes may execute, i.e., become operable, in a user privacy preserving manner.", "5.The result of the execution of the executable code in response to an incoming request is itself an executable code, e.g., an HTML (Hyper Text Markup Language) script that may be provided, e.g., to a website, that may then deliver the HTML script to one or more user communications devices.", "(Unlike conventional database systems, the response does not comprise one or more stored objects.", "It comprises executable codes.)", "In a sense, the database technology proposed herein is an improvement of both database systems and app stores since 1) it obviates the need for downloading apps before their use in user devices, 2) it allows a single input and output to address and/or serve the needs of multiple apps, and 3) provides a user privacy preserving model of managing the user preferences whilst providing personalized experiences (representations).", "Moreover, by avoiding the need to download and operate apps on the user communications device, the resources (e.g., memory, processing power, battery life) of the user communications device, which are often limited, are preserved so that they are available for other tasks.", "As mentioned earlier, the details of these various technological notions are presented later.", "Snippet Database A conventional database system stores data objects and provides them upon requests made by client programs.", "Many query languages have been described in prior art that support data retrieval requests from a database system.", "An app store may be viewed as a database system that stores computer programs (applications or “apps”).", "An app store may be searched for apps by name or other attributes describing the apps.", "A searchable index is a data structure that lists data objects indexed by one or more keywords.", "Given one or more keywords, the searchable index may be searched to find the corresponding data objects.", "For example, a web search engine supports an index that when provided with keywords, returns corresponding web page addresses.", "In co-pending U.S. patent application Ser.", "No.", "14/466,676, the contents of which are incorporated by reference in its entirety, methods are described by which web pages or other web resources are analyzed and fragments of the pages, referred to as snippets, are extracted.", "Where possible, the extracted are associated with a geographical and calendar context that also may be extracted from the web pages.", "In some cases, the snippets are obtained from web pages using web crawling mechanisms.", "In other cases, web pages are “pushed”.", "In the latter case, the pushed web pages may contain, e.g., special HTML tags, demarcating the snippets and the geographical and calendar contexts.", "Snippets may in general contain many kinds of information.", "For instance, some snippets contain executable code (or contain a link to executable code).", "In such cases, the snippets may be viewed as a kind of “app” that is to be discovered and executed based on its geographical and calendar contexts.", "Advantageously, a developer may provide one or more web pages, e.g., a web catalog, describing various executable codes that may be made available to consumers.", "Using a web crawling mechanism, the executable codes may be extracted as snippets and stored in a searchable index.", "U.S. patent application Ser.", "No.", "14/466,676, refers to such snippets as being discoverable under a geographical and/or calendar context.", "That is, a user communications device searching the searchable index of snippets may discover snippets whose geographical and calendar contexts may match that of the device itself.", "Thus, for example, a user communications device located at Yankee Stadium on game day may discover snippets whose geographical and calendar contexts match that of the device.", "When stored snippets contain executable codes, we state that the executable codes may be executed, i.e., the snippets become operable, when their geographical and calendar context match that of a user device searching the snippet index.", "FIG.", "1 shows an exemplary index comprising snippets.", "We refer to such a data structure herein as a snippet database.", "The data in the received snippets may be organized in a tabular structure whose rows identify snippets and columns identify various attributes of the snippets (as gleaned from the extraction process).", "The various illustrative attributes shown in FIG.", "1 carry the meanings shown in FIG.", "2.Thus, for instance, the attribute “Cal” refers to the calendar context and the attribute “Loc” refers to the geographical context.", "The attribute “code” refers to the case when the snippet is associated with executable code.", "In such a case, the value in the column may be the executable code or a link from where the code may be obtained.", "The attribute “Rel” in FIG.", "2 is especially noteworthy.", "This attribute specifies a list of category names that may be used to search and match snippets.", "Thus, if a search request is received for snippets matching “Music” and a snippet has a “Rel” tag “Chopin”, service logic of the snippet database may infer a match and find (“discover”) the indicated snippet.", "A developer of a snippet associated with executable codes may specify a geographical location that serves as a context associated with the snippet.", "For example, the developer may specify that the snippet applies to the geographical location (by specifying GPS coordinates, by way of example) of Yankee Stadium in New York.", "The developer may also specify a date and time, i.e., a calendar context, when the snippet becomes applicable.", "For example, the snippet may only be applicable on game days and game times.", "The idea underlying snippets and their geographical and calendar contexts is that the snippet is only discoverable and operable when the specified context is satisfied.", "That is, the user communications device requesting execution of a snippet needs to provide a calendar and a geographical context that satisfies the geographical and calendar contexts associated with the snippet in the snippet database.", "If the provided data does not satisfy the stored contexts, i.e., does not match, the snippet may not be discoverable and operable.", "In the latter case, the executable codes of the snippet are not executed and a general message may be communicated to the user communications device.", "Therefore, when making a request in accordance with the methods described herein, the user communications device should have a geographic, calendar and device context (as discerned, for instance, by one or more sensor devices associated with the user device or associated with an environment where the user device is located) that satisfies the contexts associated with a snippet in the snippet database.", "In an alternative embodiment, a user communications device may specify a user request with hypothetical geographic, device and calendar contexts, e.g., by using an appropriately designed query language.", "The snippet database may then be searched to discover snippets that satisfy the hypothetical contexts and their corresponding executable codes may be executed.", "In some embodiments, the geographical, device and calendar contexts associated with a snippet may be specified by a consumer rather than the developer of the snippet.", "That is, the snippet database may allow a consumer to author the geographical, device and calendar contexts of one or more snippets.", "For example, a consumer may specify that a snippet may be made operable for a location and time specified by the user.", "In such cases, multiple copies of the snippet may be created and stored in the snippet database so as to accommodate multiple consumers.", "In one embodiment that will be used for illustrative purposes below, the snippets are assumed to be associated with executable codes.", "An interesting case occurs when snippets with executable codes specify a geographical context.", "Consider, by way of example, a retail store that may provide snippets (with executable codes) that have a geographical context pertaining to the location of the store.", "That is, we may now say that the executable code of the snippet is to be executed (i.e., the snippet becomes operable) upon request by a user communications device when the device is in the geographical environment of the retail store.", "Thus, a consumer may be visiting a retail store.", "While within the geographical environment of the store, the consumer may discover one or more snippets with executable codes.", "When the codes are executed, the consumer may be informed, say, of the items in the store that he may prefer or items that are on sale, etc.", "That is, snippets with executable codes are computer programs that operate in specific geographical environments and may provide services to consumers in those environments.", "A consumer at Yankee Stadium on game day may be searching for food items using the search function (search engine or search app) on his user communications device.", "Thus, his geographical context may be the location of “Yankee Stadium”, his calendar context may be given by the time and data sensor of the user communications device, and his device context may be “searching for food items”.", "One or more snippets may be discoverable by such a consumer and the associated executable codes when executed may provide services to the consumer.", "For example, the executable code of a snippet may direct the consumer to a food stall.", "Environmental Datasets In co-pending U.S. patent application Ser.", "No.", "14/701,858, which is hereby incorporated by reference in its entirety, an environmental dataset was defined as data pertaining to a geographical area.", "Cell towers installed for supporting mobile communications are often used for locating mobile devices in geographical areas.", "Global Positioning Systems (GPS) further improved the accuracy of location identification.", "Smaller-sized cell tower technologies such as pico-cells, femto-cells, etc., have also been used for mobile communications and for location tracking in indoor spaces.", "Wi-Fi routers and access points have also been used for determining locations of devices.", "Recently, so-called “beacon devices” provide improved location tracking capabilities in indoor spaces.", "More recent times have seen the introduction and installation of “smart” devices such as thermostats, refrigerators, clocks, etc., that broadcast signals that may be used for location tracking, making mobile devices (and hence their users) aware of the presence of the installed device/service.", "In some cases, the installed devices may also have connections (wired or wireless) to communications networks such as the Internet.", "In certain cases, the installed devices may broadcast music, video or other multimedia data that may be received by user devices in the environment.", "An important feature of the above-mentioned devices is that they broadcast Radio-Frequency (R/F) signals that may be used by receiving devices for various purposes.", "In most cases, the range of the signals is limited, e.g., in Wi-Fi and beacon technologies the range is of the order of hundreds of yards.", "GPS provides a bigger coverage area; however, its accuracy suffers in indoor spaces.", "In one aspect, the present invention is concerned with devices that broadcast data/signals using technologies such as satellite based systems, tower-based cell systems (macro cells and micro cells), and Bluetooth or Wi-Fi-based routers, etc.", "Examples of such broadcasting devices include cell towers, pico and femto cells, GPS, Wi-Fi routers, beacon devices such as Gimbal, devices using the iBeacon specification, etc.", "We will refer to all such devices as Broadcast Devices (BDs).", "As a user communication device moves, it goes out of range of signals from certain BDs and comes into the range of signals from other BDs.", "Thus, at any given time, an area of geography may be determined wherein a receiving device (a communications device) is able to receive signals from one or more BDs.", "Such a coverage area may be referred to as an environment.", "That is, an environment is defined with respect to the receiving device and the particular BD from which it is receiving signals.", "The data pertaining to an environment is known as an environment dataset.", "It should be noted that if a mobile device is simultaneously receiving signals from two different BDs, then the mobile device is simultaneously located in two different environments, each associated with one or more different BDs.", "It should also be noted that an environment might not have a regular shape, e.g., circular or oval, etc.", "Rather, the shape of an environment is determined by the signal reception capability of the user devices in that environment.", "It is to be further noted that no assumption is being made as to where the one or more BDs are installed within an environment.", "In particular, the BDs may be installed anywhere as long as their broadcast signals may be received within a geographical area.", "For example, GPS satellites exist in Earth orbits but their signals are received at various geographical areas on the surface of the earth.", "User communications devices may receive the signals broadcast by BDs in a geographical area that defines the environment.", "Generally, user communications devices support applications (“apps”), and said apps may operate using data received from the signals transmitted by one or more BDs.", "In some cases, the app must first register to receive signals from the one or more BDs.", "When the user device's operating system receives such signals, it makes registered applications aware of the receipt of said signals.", "In common usage, when applications are made aware of a received signal, they may relay the signal to one or more servers using a network connection to a wide area network, e.g., a cloud infrastructure, wherein the servers assemble the received data into one or more datasets.", "As used herein the term Environment Data Set (EDS) is a collection of data pertaining to an environment, received either from devices in an environment or from external sources (e.g., sources external to the environment).", "A planogram is a diagram or model for describing the layout of items in an environment, in current usage most often a retail store, though it is not limited to such.", "Thus, a planogram is a type of EDS in the sense that it is data about the premises of an enterprise such as a physical retail store and the layout of its contents.", "It is usually available from external sources.", "Signal data gathered from devices such as mobile devices in an environment are another example of an EDS; in this case the dataset comprises data received by devices from the BDs in the environment.", "In this example, the dataset may in fact be gathered in real-time.", "Thus, EDS may be gathered in real-time or they may be available from third-party sources.", "In the systems and techniques described herein, we associate geographical environments with the geographical context of snippets.", "Consider, by way of example, the geographical environment of Yankee Stadium.", "We may now define one or more snippets whose geographical context is the location of “Yankee Stadium”.", "That is, the snippets become relevant in the context of Yankee Stadium.", "A user communications device when at Yankee Stadium may thus cause one or more of the executable codes of the snippets to be discovered and its associated executable codes to be executed.", "That is, we may say that the snippets become operable in the context of Yankee Stadium.", "A consumer at Yankee Stadium may thus obtain services from the execution of operable snippets.", "A retail store or other enterprise may define an environment corresponding to its location.", "For example, the retail store may define a geo-fence surrounding its store location suing GPS signals.", "The retail store may define one or more snippets whose geographical context may correspond to the location of the store.", "Furthermore, the retail store may associate one or more EDS with its location.", "Thus, we may have a situation in which executable codes may be executed on EDS pertaining to a geographic location.", "For example, the EDS may be a planogram of the retail store and the executable code of a snippet, when executed, may guide the consumer to locations within the store where certain items are displayed.", "The geographical area of a store or other enterprise may represent a geographical environment.", "A snippet whose geographic context is defined over the area of the store may thus be said to be operable in the environment.", "A smart car traversing a route along a series of stores or other enterprises may thus traverse a sequence of environments in which different snippets may be operable.", "Mediation The term mediation refers to changing one or more EDS with respect to user preferences.", "In application co-pending U.S. patent application Ser.", "No.", "14/701,858, the contents of which are incorporated by reference in its entirety, the notion of mediation has been described and the derivation of one or more representations has been explained.", "We illustrate the notion of mediation briefly in the following.", "For example, consider a user “John” in the environment of a retail store, i.e., the geographical area of the store is such that John's user device may receive broadcast signals from the environment.", "The signal data from “John's environment” is one example of an EDS.", "A planogram describing the contents, i.e., inventory, and its layout is another EDS.", "Given the two EDS as above, we may have a mediation of the EDS according to John's preferences, e.g., the EDS may be used to generate a representation of the EDS, with clothes being at the “top” of the representation because the system has inferred that John prefers clothes.", "Using the same EDS, mediation for a different user “Alice”, may yield a list in which edible items are prominent.", "In other words, mediation using the same EDS may infer different intents for different users, yielding different results.", "Whereas the above example shows that mediation of one or more EDSs may cause some of the details of an environment to be deleted or removed from the resulting representation, in general, one or more details may be added, removed, highlighted, modified, etc.", "An incremental mediation process is also possible wherein the user interacts with the representation and (e.g., explicitly) adds, deletes, modifies the contents of a representation in an interactive manner.", "A second form of mediation may be referred to as device mediation.", "Typically, device mediation refers to taking a representation derived by mediation from one or more EDSs as input and manipulating it to produce a (second) representation that fits the needs or aesthetics of one or more user communications devices.", "For example, the mediated representation of the retail environment for John may be further mediated for John's smartphone device.", "Extending the example, the mediated representation might be further mediated for John's smart glasses as a holographic image or a 3-D representation.", "This second type of mediation is also sometimes referred to as rendering.", "As used herein, the term user communications device is a consumer device that serves as a communications device for voice and/or multimedia data and that provides computational capabilities.", "It provides connectivity to various networks including but not limited to private data networks, IP networks, Internet, wide area networks, the Cloud, Public Land Mobile Network, short range wireless networks such as Wi-Fi and Bluetooth, etc.", "Examples of such devices include, without limitation, smart phones, tablets, PDAs, smart glasses, smart watches, 3-D holographic glasses, virtual reality headgear, game controllers, etc.", "It should be noted that certain user communications devices such as smart glasses and smart watches operate by associating themselves to the user's smartphone device using short-range radio protocols such as Bluetooth or Wi-Fi, etc.", "In such situations, the present invention envisions that associated devices work as a single virtual user device.", "References herein to a “user communications device” thus refer to a single device or a virtual device that consists of associated devices.", "Thus, for example, a smart watch associated with a smartphone may receive broadcast signals in an environment and may make the smartphone or the applications on the smartphone aware of the received signals, or vice versa.", "Similarly, representations may be rendered on the smartphone or the smart glasses, etc.", "It might be that a representation is produced that is further mediated to be rendered on two devices that differ in aesthetics or capabilities.", "For example, one device may support 2-D representations whereas the second device may support 3-D or holographic representations.", "Conventionally, geographic environments have been associated with apps as follows.", "A user communications device may receive data/signals from an environment by obtaining one or more apps that then “register” for specific signals, i.e., signals from certain kinds of BDs.", "For example, a retail store may define a geo-fence using GPS signals.", "It may also define an environment using beacon devices.", "(Beacon devices are small R/F transmitting devices that operate over a range of a dozen meters.)", "The retail store may provide an app that, when downloaded, may register with the operating system of the user device for signals from the beacon devices.", "Typically, each beacon device broadcasts signals that contain an identifying serial number that may be used to distinguish between different beacon devices.", "When the operating system of the user device receives such signals, it informs the registered app, which may then process the received signals.", "Thus, in order to receive and process signals, a user device must first obtain one or more apps that register for such signals.", "A user device that does not have such apps, may not receive any signals from the environment.", "Thus, apps on user devices are a pre-requisite to receiving signals from an environment.", "A consumer in an environment may receive services from apps on his user device that are receptive to signals being broadcast in the environment.", "However, this scheme suffers from the requirement that a user device must be provisioned with a suitable app before it can receive signals from an environment.", "If the consumer visits multiple environments (e.g., the consumer may visit a number of retail stores in a mall), his user device must be provisioned with suitable apps for each of the visited stores.", "In descriptions that follow, we show methods by which consumers may receive services from operable snippets without needing to download apps.", "Particularly, the idea of associating a snippet's geographic context with that of a geographical environment, may allow a snippet's executable codes to be executed (e.g., in a cloud-server arrangement) when a user device is in that geographic context.", "We describe below how such executing code may deliver services to user devices without using apps.", "User Preferences As has been mentioned above, user preferences are needed during the mediation phase.", "Conventionally, user preferences, likes, etc., are derived from historical user data.", "For example, a website possessing the purchase history of a consumer may process that history to derive the user's likes and preferences.", "A user's search history and cookie information may also be used to derive user likes and preferences.", "In some cases, user preference data may also be obtained from third-party providers.", "Typically, the consumer has no control over the processing or obtaining of his purchase history or his cookie information.", "The service provider processes the information according to its own internal mechanisms.", "In U.S. patent application Ser.", "No.", "15/475,748, the contents of which are hereby incorporated by reference in its entirety, systems and methods are described that allow computer programs or other entities to share user data and preferences.", "The sharing method provides and maintains several properties that may be desirable to both users and businesses.", "A salient feature of the sharing technology is that the user device is always in control of, and integral to, the sharing protocol.", "Consider, by way of example, a user communications device in a retail environment that is receiving signals from the environment, i.e., the user device may have a suitable app.", "The app may transmit the received signals to a server where they may be processed and one or more snippets may be executed.", "The execution of the snippets may provide services to the consumer via an app on the user device.", "In order to provide personalized services, the executable codes of the snippets may need user preferences.", "As mentioned before, conventionally, user preferences may be obtained from third-party providers or from the consumer's past purchase history.", "However, user preferences may compromise privacy of users.", "As smart devices (e.g., smart appliances) are increasingly being embedded in various environments (e.g., homes, businesses) and as the ability to control and regulate various environmental parameters increases, user preferences will play in increasingly important role and the privacy concerns of the users need to address.", "In one aspect, the subject matter described in U.S. patent application Ser.", "No.", "15/475,748 involves service providers who possess user data to process such data and derive user preferences from it.", "However, they are constrained as per the methods of U.S. patent application Ser.", "No.", "15/475,748 in the manner in which the derived user preferences may be shared with other computing entities.", "In particular, consider a first service provider SP1 who has derived user preferences for a user from the user's purchase history.", "A second service provider, SP2, wishes to acquire the derived user preferences.", "SP1 may provide user preferences to SP2 if the user in question authorizes the sharing.", "That is, a user may allow his data, e.g., preferences, at a first service provider to be provided to a second service provider.", "The algorithms used by a service provider to process user data and derive user preferences may be publically known.", "Thus, a service provider receiving user data/preferences from another service provider may be assured that proper algorithms have been used for the derivations.", "In actuality, the receiving service provider may test the received user data and preferences to ensure that the indicated algorithms were used in the derivation process.", "Thus, a service provider, upon receiving user data, may be assured of its validity and provenance.", "Such guarantees of validity and provenance may be provided to a receiving service provider by using algorithms that create cryptographic credentials that encapsulate user preferences.", "For example, an algorithm may create a credential encapsulating the user preference “user likes classical music”.", "We may view such a credential as comprising cryptographic data and an accompanying statement (e.g., a meta statement), viz., “user likes classical music”.", "The validity of the cryptographic data in a credential may be verified using techniques described in U.S. patent application Ser.", "No.", "15/475,748, which may also verify that it was generated by a known algorithm.", "A service provider may thus verify received information as to validity and provenance.", "It may then use the user preference for its own purposes.", "It is to be noted that the service provider who receives a user preference encapsulated as a cryptographic credential does not know anything about the user, other than the encapsulated preference.", "Thus, for example, a service provider may know that a user likes classical music.", "He may not however know the user's name, address or any other personal information.", "In this manner, the sharing of user preferences preserves the privacy of the user.", "That is, cryptographic objects encapsulating user preferences may be viewed as credentials referring to the user's preferences.", "Application Ser.", "No.", "15/475,748 describes how such credentials (also called cards or preference cards) may be obtained from one or more service providers by a user communications device and presented to one or more computer programs.", "Alternatively, the credentials may be provided by an external service provider directly to one or more computer programs under authorizations provided by the user communications device.", "FIG.", "3 shows an arrangement in which a user communications device 100 is within an environment 400 with broadcasting devices BD1 and BD2.The user device 100 may be provisioned with one or more preference cards by preference card issuer 300 via interface 211.Alternatively, the preference card issuer 300 may provide the preference cards directly to a database complex 200 via interface 311 under authorization of the user device 100.The database complex 200 receives one or more EDS related to the environment 400.The database complex 200 also contains a snippet database from which operable snippets may be discovered by requests emanating from the user communications device 100.", "(The entities VM 204, Website 205 and Database Processor 206 are discussed below.)", "Generating Representation(s) of an Environment for a Single User FIG.", "4 shows one example of a general method by which a user communications device may request and obtain a representation of an environment utilizing user communications devices that contain one or more suitably configured apps.", "In step 100(a), one or more developers “push” one or more snippets to a database complex.", "As mentioned above, snippets may also be extracted (“pulled”) from webpages and web catalogs by a process of, e.g., web crawling.", "The received snippets may be accompanied by one or more attributes describing the snippets.", "Generally, attributes describing the geographical, calendar and device contexts will accompany the received snippet.", "In embodiments, in an initialization step, one or more user devices may be permitted to specify the contextual attributes.", "Exemplary attributes have been shown in FIG.", "2.As mentioned earlier, in this example the snippets are assumed to have executable codes associated with them.", "In step 100(b), the database complex constructs the snippet database.", "An exemplary snippet database has been shown in FIG.", "1.In step 100(c), the database complex associates EDS with the stored snippets.", "This association may be specified via attributes by the developers of the snippets.", "For example, a developer may provide the address by specifying a link (cf.", "Link attribute, FIG.", "2) to where the EDS are stored.", "If the EDS are collected in real-time, a developer may specify the address of a computer program that, e.g., provides a stream of data using a pre-provisioned application programming interface (API).", "In step 100(d), the user device downloads one or more apps and initializes them for later use.", "For example, a consumer may download an app provided by his favorite retail store so that he may receive personalized services when he visits the store.", "As mentioned above, devices without appropriate apps may not be able to receive data/signals from environments.", "As a part of the initialization phase, service logic of the app may register with the operating system of the user device to receive data/signals from one or more environments.", "In step 200(a), the user device launches a previously downloaded and initialized app and uses features of the app to request a representation of the environment in which the user device is currently located.", "Recall that discovery of snippets and the corresponding execution of their executable codes is controlled by a matching process that matches the geographic, device and calendar context of a user device with the same contexts associated with a snippet.", "If the contexts do not match, the executable codes of the snippet are not executed, i.e., the snippet is not operable.", "The app launching may, in embodiments, be triggered by the reception of one or more data signals from one or more environments.", "In step 200(b), the app transmits its geographical, calendar and device context to the database complex.", "Note that this contextual data may be obtained by the app from one or more sensor devices associated with the user communications device, e.g., the location sensor of the user device.", "Alternatively, it may be obtained from broadcasting devices installed in the environment where the user device is located.", "In step 300(a), the database complex, having received contextual data from the user device, may now discover relevant snippets in the snippet database.", "Note that relevancy of snippets depends on the received contextual data matching the stored contextual data (the various attributes) of the snippets.", "In step 300(b), the database complex discovers one or more EDSs associated with the snippets.", "Note that, in some embodiments, the data comprising the EDSs may be collected from real-time sources, e.g., it may be broadcast from BDs installed in an environment.", "EDS data also may be available statically, e.g., from a Planogram dataset.", "In step 300(c), the database complex requests and receives user preferences.", "As described above, the user preferences may be provided by the user communications device.", "In step 300(d), the database complex changes or modifies the EDS with respect to the received user preferences and, in step 300(e), constructs executable code that is used to generate the one or more representations of the EDS accordingly.", "Conventionally, several methods are known by which data in an EDS may be changed, supplemented, removed, filtered, merged with other EDSs, etc., with respect to user preferences.", "Several types of executable codes are known in the literature, e.g., HTML scripts or Javascript.", "In step 300(f), the constructed executable codes are sent to the user device.", "In particular, the database complex may include, additionally, the executable code associated with the snippet, in the constructed executable code.", "Thus, when executed, the snippet code may provide services that are specific to the environment for which the snippet has been customized.", "In step 400(a), (an app on) the user device receives the executable codes.", "It may impose a second mediation process to render them suitable for display.", "Note that the representations may contain interactive components that support user interaction.", "For example, representations may contain clickable objects or have action buttons that launch user dialog boxes, etc.", "In step 300(d), the executable codes are rendered on the user device by the app.", "In step 500(a), the user may now interact with the executable codes using the one or more interactive components contained therein.", "We now observe that the above method suffers from the following drawbacks.", "1.A user communications device that does not have an appropriate app may not be receptive to signals/data from environments and may not be able to utilize the capabilities described herein.", "That is, having the proper app is a pre-requisite.", "2.The user communications device is asked to provide user preferences and this may be construed as an invasion of privacy.", "For example, a service provider may discover, e.g., that a user likes classical music and proceed to target the user with advertisements.", "FIG.", "5 shows an alternative method that modifies the method shown in FIG.", "4 to circumvent the above problems.", "FIG.", "5 shows two major differences from that of FIG.", "4.First, the user communications device is not required to download appropriate apps in an initialization step.", "Rather, the user device may, in one embodiment, utilize a web browser to make a page request from a website.", "For example, a consumer in a retail store, say DSW, may point his browser at the store's website, say www(dot)DSW(dot)com and the latter may display a link which when clicked re-directs the user to the database processor (cf.", "206, FIG.", "3).", "The process of re-directing requests to a different address is well-known in IP networking.", "The database processor is a supervisory program that has access to both the EDS datasets and the snippet database.", "The database processor launches a virtual machine (VM) in a computing environment.", "The VM has access to the snippet database and the EDS datasets.", "As used herein, the term “virtual machine” or “virtual machine environment” is to be given its conventional meaning as used by those of ordinary skill in the art.", "Generally, a virtual machine is an emulation of a physical computer system using hardware, firmware, software or a combination thereof.", "For instance, “operating system level virtualization” is one known technique for implementing virtual machines.", "In this technique, a physical computer is virtualized at the operating system level, enabling multiple “isolated” and “secure” “guest” (software) machines, i.e., virtual machines, to run on a single physical computer.", "The term “secure” implies that only pre-determined operations can be executed in the guest machine.", "The term “isolated” means that the operations may not access resources in other guest machines.", "All guest machines share the same kernel, but may have individual user spaces.", "Thus, computer/application programs running in a guest/virtual machine view it as a standalone computer system.", "Examples of software systems using operating system level virtualization techniques include Solaris Containers, iCore Virtual Accounts, Linux-VServer, etc.", "We note that another known technique for supporting virtual machines uses a hypervisor or virtual machine monitor that allows guest machines to run their own kernels.", "For example, hypervisor may support three guest/virtual machines running macOS, Windows, Linux, respectively, on a single physical computer.", "Major Unix vendors sell virtualized hardware, e.g., Sun Microsystems, HP, etc.", "In the descriptions that follow, a computing environment is a programmable arrangement of hardware, software and/or firmware.", "The term “database processor” may denote, in one embodiment, an operating system (OS) of a computing environment, the OS being suitably configured to support features such as virtual machines, session management, etc.", "The term “session” as used herein refers to a process of information exchange between two or more communicating devices or computer programs in which information used in the exchange may be stored in a specific memory or set of registers that are then cleared (“torn down” or “terminated”) later.", "Devices and/or computer programs may also be invited and removed from a session or may initiate or terminate one or more dialogs during a session where a dialog is a sequence of data items exchanged between devices and/or computer programs.", "Thus, while the term “database processor” is known in prior art, its use in the present invention requires several new innovations and features, e.g., the creation and management of virtual machines, etc.", "We can now explain the second major difference in FIG.", "5 from that of FIG.", "4.The difference lies in the manner in which the user preferences and a snippet's executable codes are processed in the VM.", "As explained above, the user preferences may be obtained as cryptographic objects.", "Thus, the VM receives user preferences as verified credentials that it may trust.", "Concomitantly, the VM may not store or send the received preferences to a third-party since the VM may be configured to disallow such operations.", "At the conclusion of the session with the user device, the VM may be cleared and all data and records of the VM may be cleared.", "We now describe the method of FIG.", "5 in more detail.", "In steps 100(a-c), snippets are obtained from web resources such as web sites and the like and a snippet database is constructed.", "The snippets are associated with EDS datasets, if available.", "As mentioned above, the association between EDS and snippets may be specified by developers who may use the “Link” attribute (FIG.", "2) to specify addresses from where the EDS pertaining to a snippet may be obtained.", "Alternatively, a consumer may be allowed to specify an environment, e.g., his smart home, where one or more broadcasting devices may have been installed, e.g., smart thermostats.", "The data generated from such installed devices may generally be available from one or more service providers.", "A consumer may then specify the address of such service providers using the Link attribute (as above) or the database complex may use programmatic means to infer such address and associate the EDS with snippets.", "Thus, e.g., snippets may be associated by a consumer with the environment representing his home.", "In step 200(a-b), a consumer utilizes the browser on his user device to visit the website of a service provider, e.g., a retailer.", "The visited website may contain a link that when clicked re-directs the user device to the database processor (cf.", "206, FIG.", "3).", "The consumer may be motivated to visit the website, for example, upon viewing an advertisement in an environment that is currently visiting.", "Alternatively, the consumer may be aware of the website a priori as a result of out-of-band processes.", "In step 250, the database processor creates a computing environment with a virtual machine, VM (cf.", "204, FIG.", "3), that has access to both the EDS datasets and the snippet database.", "In steps 300(a-j), we proceed as follows.", "The VM requests the user device for its geographic, device and calendar contexts and user preferences.", "The latter may also be provided under authorizations of the user device from a third-party provider using the previously discussed preference cards or credentials.", "The VM matches the device geographical, calendar and device contexts (received from the user communications device) with the attributes of the snippets in the snippet database.", "In this manner, the VM discovers the relevant snippets that, in turn, identify corresponding EDS datasets.", "The VM then modifies the EDS datasets based on the received user preferences and constructs one or more executable codes.", "In particular, the database processor may include, additionally, the executable code associated with the snippet, in the constructed executable code.", "Thus, when executed, the snippet code may provide services that are specific to the environment for which the snippet may have been customized.", "The VM sends the constructed executed code(s) to the website initially visited by the user communications device and re-directs the user communications device to the website.", "In step 400, the website incorporates the received executable codes into one or more web pages.", "In step 450(a-c), the user device receives one or more web pages from the website as a response to its initial request and renders the received web page(s).", "In step 500(a), the user may now interact with the interactive components in the rendered web pages.", "In step 500(b), the user may end his session at which point the database processor, upon being informed, e.g., by the website, clears the VM, thus clearing it of any user data.", "Generating Representation(s) of an Environment for Multiple Users The method described in FIG.", "5 may be unsuitable when representations need to be rendered for a collection of users who are in a common environment.", "We propose a process of managing multiple user preferences to solve the issue as follows.", "The VM (FIG.", "5) may receive user preferences from one or more user devices in an environment, e.g., occupants of a vehicle or a smart home, or customers in a retail store.", "The received preferences may now be rank ordered.", "For example, if the user preferences relate to music, the music pieces may be rank ordered by user preference.", "We obtain a table that lists the most popular song, followed by the second most popular song, etc.", "That is, the table is organized as frequency of users who like a song by the rank of the song.", "We may now apply a statistical distribution technique such as, for example, the discrete Pareto distribution to the obtained table.", "In a Pareto distribution, approximately 80% of the sample are obtained from 20% of the sources.", "Thus, heuristically, 80% of the occupants are likely to prefer the top 20% of the ranked songs.", "Prior art teaches many statistical distributions such as the Pareto distribution; even Pareto has many variants.", "We propose that one or more such distributions may be used as heuristics to aggregate user preferences for creating representations intended for collections of users in an environment.", "In a related embodiment, we note that personalization of Internet content on a per user basis may lead to generally deleterious consequences, e.g., “filter bubbles”, in which users receive self-enforcing content and views.", "We propose the use of the above method of aggregation of user preferences as potentially one partial solution to this problem.", "For example, all content of a certain type, say political news of the day, could be organized according to user preferences and a percentage chosen for delivery to a group of users as their personalized content.", "That is, we propose to replace individually personalized content with personalization for a group of users.", "Alternatively, we could add items obtained by the group personalization method to the individual personalization derived for a user.", "In this manner, users would be served, e.g., news of the day, that is statistically likely to be their preference and, hence, may contain news that is not congruent to their preferences, i.e., some of the news served to them may lie outside their “filter bubbles”.", "Generating Representation(s) for a Sequence of Environments We note, as discussed in the illustrative embodiment above, that in some situations, a collection of representations may be needed, e.g., a smart car may be traversing a known route and thus may enter and exit different environments.", "Thus, the en route environments may be determined by using navigation software and representations may be pre-computed and made available to the VM a priori.", "Thus, the VM may pre-calculate executable codes using (aggregated) user preferences, if needed, and provide the representations to the web site in synchronization with the traversal of the route by the smart car.", "Alternative Embodiment Those of ordinary skill in the art would have noticed that in the above descriptions, we use a computer program, i.e.", "the VM, to create executable codes that may contain executable code from one or more snippets.", "Thus, technically, these two types of executable codes may in practice be merged into a single executable code.", "One well-known technique for doing this would be the use of subroutines by which one computer program may be included in another.", "This implies, inter alia, that the concept of snippets may be dispensed with entirely (since in the examples above, we limited ourselves to snippets with executable codes).", "In such alternative embodiments, executable code may be developed and associated with one or more geographical environments using any number of methods.", "For example, a database system may be developed that maintains a table of executable codes associated with various geographical environments and their corresponding EDS.", "That is, the columns of such a table may comprise “Executable Codes”, “Geographic Environment” (specified as e.g., GPS coordinates), and “EDS” (locations from which corresponding EDS may be obtained).", "Concomitantly, since the notion of snippets may be dispensed with in this alternative embodiment, the concept of associating snippets with EDS may also be dispensed with.", "Furthermore, an environment may not need to install broadcasting devices since, in our invention, the user foregoes the use of apps; rather, the user launches the browser on his user device to visit the website of the environment he is currently visiting.", "Because the user does not need to use one or more apps, the signals from the one or more BDs in an environment are of no use to the user device.", "In summary, in an alternative embodiment, a user visits a geographical environment and uses the browser on his user device to visit the environment's website.", "The website may, in one embodiment, re-direct the user device to the database processor.", "The database processor may then create a VM in a computing environment.", "The VM may ask and receive various contextual information from the user device to discover relevant executable codes in the tabular data structure discussed above.", "For example, the user device may provide its GPS location information and the VM may search and match the provided GPS location with the GPS location data specified in the table.", "Thus, the VM may discover the EDS and the executable codes for the current environment of the user device.", "Note that the VM may be provided access to the tabular data structure to carry out the actions described herein.", "The VM may then create executable codes and send them to the website which may convert them into one or more web pages for use on the browser of the user device.", "Since installing beacons and other broadcasting devices are costly and require continued maintenance, such an embodiment would offer a significant commercial advantage.", "It is to be noted that most user communications devices provide web browser software as an integral feature.", "Furthermore, the user may configure the operating system of a user device to allow the browser to access his location data and data from miscellaneous other associated sensor devices.", "Illustrative Computing Environment Aspects of the subject matter described herein may be described in the general context of computer-executable instructions, such as program modules, being executed by a computer.", "Generally, program modules include routines, programs, objects, components, data structures, and so forth, which perform particular tasks or implement particular abstract data types.", "Aspects of the subject matter described herein may also be practiced in distributed computing environments where tasks are performed by remote processing devices that are linked through a communications network.", "In a distributed computing environment, program modules may be located in both local and remote computer storage media including memory storage devices.", "Also, it is noted that some embodiments have been described as a process which is depicted as a sequence of steps, flow diagram or block diagram.", "Although each may describe the operations as a sequential process, many of the operations can be performed in parallel or concurrently.", "In addition, the order of the operations may be rearranged.", "A process may have additional steps not included in the figure.", "The claimed subject matter may be implemented as a method, apparatus, or article of manufacture using standard programming and/or engineering techniques to produce software, firmware, hardware, or any combination thereof to control a computer to implement the disclosed subject matter.", "For instance, the claimed subject matter may be implemented as a computer-readable storage medium embedded with a computer executable program, which encompasses a computer program accessible from any computer-readable storage device or storage media.", "For example, computer readable storage media can include but are not limited to magnetic storage devices (e.g., hard disk, floppy disk, magnetic strips .", ".", ".", "), optical disks (e.g., compact disk (CD), digital versatile disk (DVD) .", ".", ".", "), smart cards, and flash memory devices (e.g., card, stick, key drive .", ".", ".", ").", "However, computer readable storage media do not include transitory forms of storage such as propagating signals, for example.", "Of course, those skilled in the art will recognize many modifications may be made to this configuration without departing from the scope or spirit of the claimed subject matter.", "Moreover, as used in this application, the terms “component,” “module,” “engine,” “system,” “apparatus,” “interface,” or the like are generally intended to refer to a computer-related entity, either hardware, a combination of hardware and software, software, or software in execution.", "For example, a component may be, but is not limited to being, a process running on a processor, a processor, an object, an executable, a thread of execution, a program, and/or a computer.", "By way of illustration, both an application running on a controller and the controller can be a component.", "One or more components may reside within a process and/or thread of execution and a component may be localized on one computer and/or distributed between two or more computers.", "The foregoing described embodiments depict different components contained within, or connected with, different other components.", "It is to be understood that such depicted architectures are merely exemplary, and that in fact many other architectures can be implemented which achieve the same functionality.", "In a conceptual sense, any arrangement of components to achieve the same functionality is effectively “associated” such that the desired functionality is achieved.", "Hence, any two components herein combined to achieve a particular functionality can be seen as “associated with” each other such that the desired functionality is achieved, irrespective of architectures or intermediary components.", "Likewise, any two components so associated can also be viewed as being “operably connected”, or “operably coupled”, to each other to achieve the desired functionality.", "FIG.", "6 shows an example architecture 800 for a device such as the user communication devices or database complex shown in FIG.", "3 which are capable of executing the various components described herein for implementing aspects of the techniques described herein.", "Thus, the architecture 800 illustrated in FIG.", "12 shows an architecture that may be adapted for a server computer, mobile phone, a PDA, a smartphone, a desktop computer, a netbook computer, a tablet computer, GPS device, gaming console, and/or a laptop computer.", "The architecture 800 may be utilized to execute any aspect of the components presented herein.", "The architecture 800 illustrated in FIG.", "6 includes a CPU (Central Processing Unit) 802, a system memory 804, including a RAM 806 and a ROM 808, and a system bus 810 that couples the memory 804 to the CPU 802.A basic input/output system containing the basic routines that help to transfer information between elements within the architecture 800, such as during startup, is stored in the ROM 808.The architecture 800 further includes a mass storage device 812 for storing software code or other computer-executed code that is utilized to implement applications, the file system, and the operating system.", "The mass storage device 812 is connected to the CPU 802 through a mass storage controller (not shown) connected to the bus 810.The mass storage device 812 and its associated computer-readable storage media provide non-volatile storage for the architecture 800.Although the description of computer-readable storage media contained herein refers to a mass storage device, such as a hard disk or CD-ROM drive, it should be appreciated by those skilled in the art that computer-readable storage media can be any available storage media that can be accessed by the architecture 800.Although the subject matter has been described in language specific to structural features and/or methodological acts, it is to be understood that the subject matter defined in the appended claims is not necessarily limited to the specific features or acts described above.", "Rather, the specific features and acts described are disclosed as example forms of implementing the claims." ] ]
Patent_15874395
[ [ "RNAi Inhibition of Alpha-ENaC Expression", "The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides." ], [ "1.A composition comprising an iRNA agent for inhibiting the expression of an alpha-ENaC gene, wherein the iRNA agent comprises a sense strand and an antisense strand, wherein the antisense strand comprises a nucleotide sequence of nucleotides 2-18 of SEQ ID NO: 980, SEQ ID NO: 1298, or SEQ ID NO: 1368.2.The composition of claim 1, wherein the sense strand of the iRNA agent comprises a nucleotide sequence of nucleotides 2-18 of SEQ ID NO: 979, SEQ ID NO: 1297, or SEQ ID NO: 1367.3.The composition of claim 1, wherein the antisense strand of the iRNA agent and the sense strand of the iRNA agent are each 19 to 23 nucleotides in length.", "4.The composition of claim 1, wherein the iRNA agent comprises at least one modified nucleotide and/or at least one phosphate linker modification.", "5.The composition of claim 2, wherein the iRNA agent comprises at least on modified nucleotide and/or at least one phosphate linker modification.", "6.The composition of claim 4, wherein the iRNA agent comprises one or more 2′-modified nucleotides and/or one or more phosphorothioates.", "7.The composition of claim 5, wherein the iRNA agent comprises one or more 2′-modified nucleotides and/or one or more phosphorothioates.", "8.The composition of claim 6, wherein the one or more 2′-modified nucleotides are independently selected from the group consisting of: 2′-deoxy, 2′-deoxy-2′-fluoro, 2′-O-methyl, 2′-O-methoxyethyl (2′-O-MOE), 2′-O-aminopropyl (2′-O-AP), 2′-O-dimethylaminoethyl (2′-O-DMAOE), 2′-O-dimethylarninopropyl(2′-O-DMAP), 2′-O-dimethylaminoethyloxyethyl (2′-O-DMAEOE), and 2′-O—N-methylacetamido (2′-O-NMA).", "9.The composition of claim 7, wherein the one or more 2′-modified nucleotides are independently selected from the group consisting of: 2′-deoxy, 2′-deoxy-2′-fluoro, 2′-O-methyl, 2′-O-methoxyethyl (2′-O-MOE), 2′-O-aminopropyl (2′-O-AP), 2′-O-dimethylaminoethyl (2′-O-DMAOE), 2′-O-dimethylarninopropyl(2′-O-DMAP), 2′-O-dimethylaminoethyloxyethyl (2′-O-DMAEOE), and 2′-O—N-methylacetamido (2′-O-NMA).", "10.The composition of claim 4, wherein the sense strand and/or the antisense strand contains a 3′ overhang.", "11.The composition of claim 4, wherein the sense strand and/or the antisense strand contains a 5′ overhang.", "12.The composition of claim 4, wherein the iRNA agent comprises at least one blunt end.", "13.The composition of claim 4, further comprising a buffer, diluent, penetration enhancer, carrier compound, and/or pharmaceutically acceptable carrier or excipient.", "14.The composition of claim 4, wherein the composition is presented in unit dosage form.", "15.The composition of claim 1, wherein the iRNA agent is ligated to one or more diagnostic compound, reporter group, cross-linking agent, nuclease-resistance conferring moiety, natural or unusual nucleobase, lipophilic molecule, cholesterol, lipid, lectin, steroid, uvaol, hecigenin, diosgenin, terpene, triterpene, sarsasapogenin, Friedelin, epifriedelanol-derivatized lithocholic acid, vitamin, carbohydrate, dextran, pullulan, chitin, chitosan, synthetic carbohydrate, Oligo Lactate 15-mer, natural polymer, low- or medium-molecular weight polymer, inulin, cyclodextrin, hyaluronic acid, protein, protein-binding agent, integrin-targeting molecule, epithelial receptor ligand, polycationic, peptide, polyamine, peptide mimic, and/or transferrin.", "16.The composition of claim 4, further comprising one or more known agents effective in treatment of ENaC-related disorders.", "17.The composition of claim 16, wherein the known agent is selected from the group consisting of: anti-inflammatory drug, bronchodilatory drug, antihistamine, anti-tussive drug, antibiotic, DNase drug substance, epithelial sodium channel blocker.", "18.The composition of claim 5, wherein the iRNA agent comprises: a) an antisense strand comprising a nucleotide sequence of nucleotides 1-19 of SEQ ID NO: 980, and a sense strand comprising a nucleotide sequence of nucleotides 1-19 of SEQ ID NO: 979, b) an antisense strand comprising a nucleotide sequence of nucleotides 1-19 of SEQ ID NO: 1298 and a sense strand comprising a nucleotide sequence of nucleotides 1-19 of SEQ ID NO: 1297, or c) an antisense strand comprising a nucleotide sequence of nucleotides 1-19 of SEQ ID NO: 1368, and a sense strand comprising a nucleotide sequence of nucleotides 1-19 of SEQ ID NO: 1367.19.A method of treating a human subject having a pathological state mediated at least in part by alpha-ENaC expression, the method comprising the step of administering to the subject a therapeutically effective amount of a composition of claim 4.20.The method of claim 19, wherein the pathological state is cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease (COPD), asthma, respiratory tract infections, lung carcinoma, Liddles syndrome, hypertension, renal insufficiency, and/or electrolyte imbalance.", "21.The method of claim 19, wherein the composition is administered via inhalation/intranasal administration or systemically or subcutaneously.", "22.A method of inhibiting the expression of an alpha-ENaC gene in a cell, the method comprising administering to the cell an effective amount of a composition of claim 4.23.A composition comprising an iRNA agent comprising a sense strand and an antisense strand, wherein: the antisense strand comprises a nucleotide sequence of nucleotides 2-18 of any of the antisense strands Table 1A, Table 1B, Table 1C, or Table 1D." ], [ "<SOH> BACKGROUND <EOH>RNA interference or “RNAi” is a term initially coined by Fire and co-workers to describe the observation that double-stranded RNA (dsRNA) can block gene expression when it is introduced into worms (Fire et al., Nature 391:806-811, 1998).", "Short dsRNA directs gene-specific, post-transcriptional silencing in many organisms, including vertebrates, and has provided a new tool for studying gene function.", "This technology has been reviewed numerous times recently, see, for example Novina, C. D, and Sharp, P., Nature 2004, 430:161, and Sandy, P., et al., Biotechniques 2005, 39:215, hereby incorporated by reference.", "The mucosal surfaces at the interface between the environment and the body have evolved a number of protective mechanisms.", "A principal form of such innate defense is to cleanse these surfaces with liquid.", "Typically, the quantity of the liquid layer on a mucosal surface reflects the balance between epithelial liquid secretion, often reflecting anion (Cl − and/or HCO 3 − ) secretion coupled with water (and a cation counter-ion), and epithelial liquid absorption, often reflecting Na + absorption, coupled with water and counter anion (Cl − and/or HCO 3 − ).", "Many diseases of mucosal surfaces are caused by too little protective liquid on those mucosal surfaces created by an imbalance between secretion (too little) and absorption (relatively too much).", "The defective salt transport processes that characterize these mucosal dysfunctions reside in the epithelial layer of the mucosal surface.", "One approach to replenish the protective liquid layer on mucosal surfaces is to “re-balance” the system by blocking Na + channel mediated liquid absorption.", "The epithelial protein that mediates the rate-limiting step of Na + and liquid absorption is the epithelial Na + channel (ENaC).", "Alpha-ENaC is positioned on the apical surface of the epithelium, i.e.", "the mucosal surface-environmental interface.", "Inhibition of alpha-ENaC mediated Na + mediated liquid absorption may achieve therapeutic utility.", "Therefore, there is a need for the development of effective therapies for the treatment and prevention of diseases or disorders in which alpha-ENaC is implicated, e.g.", "cystic fibrosis in humans and animals, and particularly for therapies with high efficiency.", "One prerequisite for high efficiency is that the active ingredient is not degraded too quickly in a physiological environment." ], [ "<SOH> SUMMARY <EOH>The present invention provides specific compositions and methods that are useful in reducing alpha-ENaC levels in a subject, e.g., a mammal, such as a human, e.g.", "by inhaled, intranasal or intratracheal administration of such agents.", "The present invention specifically provides iRNA agents consisting of, consisting essentially of or comprising at least 15 or more contiguous nucleotides for alpha-ENaC, and more particularly agents comprising 15 or more contiguous nucleotides from one of the sequences provided in Tables 1A-1D.", "The iRNA agent preferably comprises less than 30 nucleotides per strand, e.g., 21-23 nucleotides, such as those provided in Tables 1A-1D.", "The double stranded iRNA agent can either have blunt ends or more preferably have overhangs of 1-4 nucleotides from one or both 3′ ends of the agent.", "Further, the iRNA agent can either contain only naturally occuring ribonucleotide subunits, or can be synthesized so as to contain one or more modifications to the sugar, phosphate or base of one or more of the ribonucleotide subunits that is included in the agent.", "The iRNA agent can be further modified so as to be attached to a ligand that is selected to improve stability, distribution or cellular uptake of the agent, e.g.", "cholesterol.", "The iRNA agents can further be in isolated form or can be part of a pharmaceutical composition used for the methods described herein, particularly as a pharmaceutical composition formulated for delivery to the lungs or nasal passage or formulated for parental administration.", "The pharmaceutical compositions can contain one or more iRNA agents, and in some embodiments, will contain two or more iRNA agents, each one directed to a different segment the alpha-ENaC gene.", "One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one non-natural nucleobase.", "In certain embodiments, the non-natural nucleobase is difluorotolyl, nitroindolyl, nitropyrrolyl, or nitroimidazolyl.", "In a preferred embodiment, the non-natural nucleobase is difluorotolyl.", "In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a non-natural nucleobase.", "In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a non-natural nucleobase.", "The present invention further provides methods for reducing the level of alpha-ENaC mRNA in a cell.", "Such methods comprise the step of administering one of the iRNA agents of the present invention to a subject as further described below.", "The present methods utilize the cellular mechanisms involved in RNA interference to selectively degrade the target RNA in a cell and are comprised of the step of contacting a cell with one of the iRNA agents of the present invention.", "Such methods can be performed directly on a cell or can be performed on a mammalian subject by administering to a subject one of the iRNA agents/pharmaceutical compositions of the present invention.", "Reduction of target RNA in a cell results in a reduction in the amount of encoded protein produced, and in an organism, results in reduction of epithelial potential difference, decreased fluid absorption and increased mucociliary clearance.", "The methods and compositions of the invention, e.g., the methods and iRNA agent compositions can be used with any dosage and/or formulation described herein, as well as with any route of administration described herein.", "The details of one or more embodiments of the invention are set forth in the accompanying drawings and the description below.", "Other features, objects, and advantages of the invention will be apparent from this description, the drawings, and from the claims.", "This application incorporates all cited references, patents, and patent applications by references in their entirety for all purposes." ], [ "TECHNICAL FIELD The invention relates to the field of ENaC-mediated airway ion transport and compositions and methods for modulating alpha-ENaC expression, and more particularly to the down-regulation of alpha-ENaC by oligonucleotides via RNA interference which are administered locally to the lungs and nasal passage via inhalation/intranasal administration, or are administered systemically, e.g.", "by via intravenous injection.", "BACKGROUND RNA interference or “RNAi” is a term initially coined by Fire and co-workers to describe the observation that double-stranded RNA (dsRNA) can block gene expression when it is introduced into worms (Fire et al., Nature 391:806-811, 1998).", "Short dsRNA directs gene-specific, post-transcriptional silencing in many organisms, including vertebrates, and has provided a new tool for studying gene function.", "This technology has been reviewed numerous times recently, see, for example Novina, C. D, and Sharp, P., Nature 2004, 430:161, and Sandy, P., et al., Biotechniques 2005, 39:215, hereby incorporated by reference.", "The mucosal surfaces at the interface between the environment and the body have evolved a number of protective mechanisms.", "A principal form of such innate defense is to cleanse these surfaces with liquid.", "Typically, the quantity of the liquid layer on a mucosal surface reflects the balance between epithelial liquid secretion, often reflecting anion (Cl− and/or HCO3−) secretion coupled with water (and a cation counter-ion), and epithelial liquid absorption, often reflecting Na+ absorption, coupled with water and counter anion (Cl− and/or HCO3−).", "Many diseases of mucosal surfaces are caused by too little protective liquid on those mucosal surfaces created by an imbalance between secretion (too little) and absorption (relatively too much).", "The defective salt transport processes that characterize these mucosal dysfunctions reside in the epithelial layer of the mucosal surface.", "One approach to replenish the protective liquid layer on mucosal surfaces is to “re-balance” the system by blocking Na+ channel mediated liquid absorption.", "The epithelial protein that mediates the rate-limiting step of Na+ and liquid absorption is the epithelial Na+ channel (ENaC).", "Alpha-ENaC is positioned on the apical surface of the epithelium, i.e.", "the mucosal surface-environmental interface.", "Inhibition of alpha-ENaC mediated Na+ mediated liquid absorption may achieve therapeutic utility.", "Therefore, there is a need for the development of effective therapies for the treatment and prevention of diseases or disorders in which alpha-ENaC is implicated, e.g.", "cystic fibrosis in humans and animals, and particularly for therapies with high efficiency.", "One prerequisite for high efficiency is that the active ingredient is not degraded too quickly in a physiological environment.", "SUMMARY The present invention provides specific compositions and methods that are useful in reducing alpha-ENaC levels in a subject, e.g., a mammal, such as a human, e.g.", "by inhaled, intranasal or intratracheal administration of such agents.", "The present invention specifically provides iRNA agents consisting of, consisting essentially of or comprising at least 15 or more contiguous nucleotides for alpha-ENaC, and more particularly agents comprising 15 or more contiguous nucleotides from one of the sequences provided in Tables 1A-1D.", "The iRNA agent preferably comprises less than 30 nucleotides per strand, e.g., 21-23 nucleotides, such as those provided in Tables 1A-1D.", "The double stranded iRNA agent can either have blunt ends or more preferably have overhangs of 1-4 nucleotides from one or both 3′ ends of the agent.", "Further, the iRNA agent can either contain only naturally occuring ribonucleotide subunits, or can be synthesized so as to contain one or more modifications to the sugar, phosphate or base of one or more of the ribonucleotide subunits that is included in the agent.", "The iRNA agent can be further modified so as to be attached to a ligand that is selected to improve stability, distribution or cellular uptake of the agent, e.g.", "cholesterol.", "The iRNA agents can further be in isolated form or can be part of a pharmaceutical composition used for the methods described herein, particularly as a pharmaceutical composition formulated for delivery to the lungs or nasal passage or formulated for parental administration.", "The pharmaceutical compositions can contain one or more iRNA agents, and in some embodiments, will contain two or more iRNA agents, each one directed to a different segment the alpha-ENaC gene.", "One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one non-natural nucleobase.", "In certain embodiments, the non-natural nucleobase is difluorotolyl, nitroindolyl, nitropyrrolyl, or nitroimidazolyl.", "In a preferred embodiment, the non-natural nucleobase is difluorotolyl.", "In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a non-natural nucleobase.", "In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a non-natural nucleobase.", "The present invention further provides methods for reducing the level of alpha-ENaC mRNA in a cell.", "Such methods comprise the step of administering one of the iRNA agents of the present invention to a subject as further described below.", "The present methods utilize the cellular mechanisms involved in RNA interference to selectively degrade the target RNA in a cell and are comprised of the step of contacting a cell with one of the iRNA agents of the present invention.", "Such methods can be performed directly on a cell or can be performed on a mammalian subject by administering to a subject one of the iRNA agents/pharmaceutical compositions of the present invention.", "Reduction of target RNA in a cell results in a reduction in the amount of encoded protein produced, and in an organism, results in reduction of epithelial potential difference, decreased fluid absorption and increased mucociliary clearance.", "The methods and compositions of the invention, e.g., the methods and iRNA agent compositions can be used with any dosage and/or formulation described herein, as well as with any route of administration described herein.", "The details of one or more embodiments of the invention are set forth in the accompanying drawings and the description below.", "Other features, objects, and advantages of the invention will be apparent from this description, the drawings, and from the claims.", "This application incorporates all cited references, patents, and patent applications by references in their entirety for all purposes.", "BRIEF DESCRIPTION OF THE FIGURES FIG.", "1: Restriction digest map of pXoon contsruct for cloned cynomolgous α-EnaC.", "FIG.", "2: Cloning of the predicted off-target and the on-target recognition sites into the AY535007 dual luciferase reporter construct.", "Fragments consist of 19nt of the predicted target site and 10 nt of flanking sequence at both the 5′ and 3′ ends.", "DETAILED DESCRIPTION OF CERTAIN PREFERRED EMBODIMENTS OF THE INVENTION For ease of exposition the term “nucleotide” or “ribonucleotide” is sometimes used herein in reference to one or more monomeric subunits of an RNA agent.", "It will be understood that the usage of the term “ribonucleotide” or “nucleotide” herein can, in the case of a modified RNA or nucleotide surrogate, also refer to a modified nucleotide, or surrogate replacement moiety, as further described below, at one or more positions.", "An “RNA agent” as used herein, is an unmodified RNA, modified RNA, or nucleoside surrogate, each of which is described herein or is well known in the RNA synthetic art.", "While numerous modified RNAs and nucleoside surrogates are described, preferred examples include those which have greater resistance to nuclease degradation than do unmodified RNAs.", "Preferred examples include those that have a 2′ sugar modification, a modification in a single strand overhang, preferably a 3′ single strand overhang, or, particularly if single stranded, a 5′-modification which includes one or more phosphate groups or one or more analogs of a phosphate group.", "An “iRNA agent” (abbreviation for “interfering RNA agent”) as used herein, is an RNA agent, which can downregulate the expression of a target gene, e.g.", "ENaC gene SCNN1A.", "While not wishing to be bound by theory, an iRNA agent may act by one or more of a number of mechanisms, including post-transcriptional cleavage of a target mRNA sometimes referred to in the art as RNAi, or pre-transcriptional or pre-translational mechanisms.", "A “ds iRNA agent” (abbreviation for “double stranded iRNA agent”), as used herein, is an iRNA agent which includes more than one, and preferably two, strands in which interstrand hybridization can form a region of duplex structure.", "A “strand” herein refers to a contigouous sequence of nucleotides (including non-naturally occurring or modified nucleotides).", "The two or more strands may be, or each form a part of, separate molecules, or they may be covalently interconnected, e.g., by a linker, e.g., a polyethyleneglycol linker, to form one molecule.", "At least one strand can include a region which is sufficiently complementary to a target RNA.", "Such strand is termed the “antisense strand.” A second strand of the dsRNA agent, which comprises a region complementary to the antisense strand, is termed the “sense strand.” However, a ds iRNA agent can also be formed from a single RNA molecule which is at least partly self-complementary, forming, e.g., a hairpin or panhandle structure, including a duplex region.", "The latter are herein referred to as short hairpin RNAs or shRNAs.", "In such case, the term “strand” refers to one of the regions of the RNA molecule that is complementary to another region of the same RNA molecule.", "Although, in mammalian cells, long ds iRNA agents can induce the interferon response which is frequently deleterious, short ds iRNA agents do not trigger the interferon response, at least not to an extent that is deleterious to the cell and/or host (Manche et al., Mol.", "Cell.", "Biol.", "12:5238, 1992; Lee et al., Virology 199:491, 1994; Castelli et al., J. Exp.", "Med.", "186:967, 1997; Zheng et al., RNA 10:1934, 2004; Heidel et al., Nature Biotechnol.", "22 1579).", "The iRNA agents of the present invention include molecules which are sufficiently short that they do not trigger a deleterious non-specific interferon response in normal mammalian cells.", "Thus, the administration of a composition including an iRNA agent (e.g., formulated as described herein) to a subject can be used to decrease expression of alpha-ENaC in the subject, while circumventing an interferon response.", "Molecules that are short enough that they do not trigger a deleterious interferon response are termed siRNA agents or siRNAs herein.", "“siRNA agent” or “siRNA” as used herein, refers to an iRNA agent, e.g., a ds iRNA agent, that is sufficiently short that it does not induce a deleterious interferon response in a mammalian, and particularly a human, cell, e.g., it has a duplexed region of less than 60 but preferably less than 50, 40, or 30 nucleotide pairs.", "The isolated iRNA agents described herein, including ds iRNA agents and siRNA agents, can mediate the decreased expression of alpha-ENaC, e.g., by RNA degradation.", "For convenience, such RNA is also referred to herein as the RNA to be silenced.", "Such a nucleic acid is also referred to as a “target RNA”, sometimes “target RNA molecule” or sometimes “target gene”.", "As used herein, the phrase “mediates RNAi” refers to the ability of an agent to silence, in a sequence-specific manner, a target gene.", "“Silencing a target gene” means the process whereby a cell containing and/or expressing a certain product of the target gene when not in contact with the agent, will contain and/or express at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% less of such gene product when contacted with the agent, as compared to a similar cell which has not been contacted with the agent.", "Such product of the target gene can, for example, be a messenger RNA (mRNA), a protein, or a regulatory element.", "As used herein, the term “complementary” is used to indicate a sufficient degree of complementarity such that stable and specific binding occurs between a compound of the invention and a target RNA molecule, e.g., alpha-ENaC mRNA.", "Specific binding requires a sufficient degree of complementarity to avoid non-specific binding of the oligomeric compound to non-target sequences under conditions in which specific binding is desired, i.e., under physiological conditions in the case of in vivo assays or therapeutic treatment, or in the case of in vitro assays, under conditions in which the assays are performed.", "The non-target sequences typically differ from the target sequences by at least 2, 3 or 4 nucleotides.", "As used herein, an iRNA agent is “sufficiently complementary” to a target RNA, e.g., a target mRNA (e.g., alpha-ENaC mRNA) if the iRNA agent reduces the production of a protein encoded by the target RNA in a cell.", "The iRNA agent may also be “exactly complementary” to the target RNA, e.g., the target RNA and the iRNA agent anneal, preferably to form a hybrid made exclusively of Watson-Crick basepairs in the region of exact complementarity.", "A “sufficiently complementary” iRNA agent can include an internal region (e.g., of at least 10 nucleotides) that is exactly complementary to a target alpha-ENaC RNA.", "Moreover, in some embodiments, the iRNA agent specifically discriminates a single-nucleotide difference.", "In this case, the iRNA agent only mediates RNAi if exact complementarity is found in the region (e.g., within 7 nucleotides of) the single-nucleotide difference.", "Preferred iRNA agents will be based on or consist of or comprise the sense and antisense sequences provided in Tables 1A-1D.", "As used herein, “essentially identical” when used referring to a first nucleotide sequence in comparison to a second nucleotide sequence means that the first nucleotide sequence is identical to the second nucleotide sequence except for up to one, two or three nucleotide substitutions (e.g., adenosine replaced by uracil).", "“Essentially retaining the ability to inhibit alpha-ENaC expression in cultured human cells,” as used herein referring to an iRNA agent not identical to but derived from one of the iRNA agents of Tables 1A-1D by deletion, addition or substitution of nucleotides, means that the derived iRNA agent possesses an inhibitory activity not less than 20% of the inhibitory activity of the iRNA agent of Tables 1A-1D from which it was derived.", "For example, an iRNA agent derived from an iRNA agent of Tables 1A-1D which lowers the amount of alpha-ENaC mRNA present in cultured human cells by 70% may itself lower the amount of mRNA present in cultured human cells by at least 50% in order to be considered as essentially retaining the ability to inhibit alpha-ENaC replication in cultured human cells.", "Optionally, an iRNA agent of the invention may lower the amount of alpha-ENaC mRNA present in cultured human cells by at least 50%.", "As used herein, a “subject” refers to a mammalian organism undergoing treatment for a disorder mediated by alpha-ENaC.", "The subject can be any mammal, such as a cow, horse, mouse, rat, dog, pig, goat, or a primate.", "In the preferred embodiment, the subject is a human.", "Design and Selection of iRNA Agents As used herein, “disorders associated with alpha-ENaC expression” refers to any biological or pathological state that (1) is mediated at least in part by the presence of alpha-ENaC and (2) whose outcome can be affected by reducing the level of the alpha-ENaC present.", "Specific disorders associated with alpha-ENaC expression are noted below.", "The present invention is based on the design, synthesis and generation of iRNA agents that target alpha-ENaC and the demonstration of silencing of the alpha-ENaC gene in vitro in cultured cells after incubation with an iRNA agent, and the resulting protective effect towards alpha-ENaC mediated disorders.", "An iRNA agent can be rationally designed based on sequence information and desired characteristics.", "For example, an iRNA agent can be designed according to the relative melting temperature of the candidate duplex.", "Generally, the duplex should have a lower melting temperature at the 5′ end of the antisense strand than at the 3′ end of the antisense strand.", "The present invention provides compositions containing siRNA(s) and/or shRNA(s) targeted to one or more alpha-ENaC transcripts.", "For any particular gene target that is selected, the design of siRNAs or shRNAs for use in accordance with the present invention will preferably follow certain guidelines.", "Also, in many cases, the agent that is delivered to a cell according to the present invention may undergo one or more processing steps before becoming an active suppressing agent (see below for further discussion); in such cases, those of ordinary skill in the art will appreciate that the relevant agent will preferably be designed to include sequences that may be necessary for its processing.", "Diseases mediated by dysfunction of the epithelial sodium channel, include diseases associated with the regulation of fluid volumes across epithelial membranes.", "For example, the volume of airway surface liquid is a key regulator of mucociliary clearance and the maintenance of lung health.", "The blockade of the epithelial sodium channel will promote fluid accumulation on the mucosal side of the airway epithelium thereby promoting mucus clearance and preventing the accumulation of mucus and sputum in respiratory tissues (including lung airways).", "Such diseases include respiratory diseases, such as cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease (COPD), asthma, respiratory tract infections (acute and chronic; viral and bacterial) and lung carcinoma.", "Diseases mediated by blockade of the epithelial sodium channel also include diseases other than respiratory diseases that are associated with abnormal fluid regulation across an epithelium, perhaps involving abnormal physiology of the protective surface liquids on their surface, e.g., xerostomia (dry mouth) or keratoconjunctivitis sire (dry eye).", "Furthermore, blockade of the epithelial sodium channel in the kidney could be used to promote diuresis and thereby induce a hypotensive effect.", "Treatment in accordance with the invention may be symptomatic or prophylactic.", "Asthma includes both intrinsic (non-allergic) asthma and extrinsic (allergic) asthma, mild asthma, moderate asthma, severe asthma, bronchitic asthma, exercise-induced asthma, occupational asthma and asthma induced following bacterial infection.", "Treatment of asthma is also to be understood as embracing treatment of subjects, e.g., of less than 4 or 5 years of age, exhibiting wheezing symptoms and diagnosed or diagnosable as “wheezy infants”, an established patient category of major medical concern and now often identified as incipient or early-phase asthmatics.", "(For convenience this particular asthmatic condition is referred to as “wheezy-infant syndrome”.)", "Prophylactic efficacy in the treatment of asthma will be evidenced by reduced frequency or severity of symptomatic attack, e.g., of acute asthmatic or bronchoconstrictor attack, improvement in lung function or improved airways hyperreactivity.", "It may further be evidenced by reduced requirement for other, symptomatic therapy, i.e., therapy for or intended to restrict or abort symptomatic attack when it occurs, e.g., anti-inflammatory (e.g., corticosteroid) or bronchodilatory.", "Prophylactic benefit in asthma may, in particular, be apparent in subjects prone to “morning dipping”.", "“Morning dipping” is a recognized asthmatic syndrome, common to a substantial percentage of asthmatics and characterized by asthma attack, e.g., between the hours of about 4-6 am, i.e., at a time normally substantially distant from any previously administered symptomatic asthma therapy.", "Chronic obstructive pulmonary disease includes chronic bronchitis or dyspnea associated therewith, emphysema, as well as exacerbation of airways hyperreactivity consequent to other drug therapy, in particular, other inhaled drug therapy.", "The invention is also applicable to the treatment of bronchitis of whatever type or genesis including, e.g., acute, arachidic, catarrhal, croupus, chronic or phthinoid bronchitis.", "Based on the results shown herein, the present invention provides iRNA agents that reduce alpha-ENaC expression in cultured cells and in a subject, e.g.", "a mammalian, for example a human.", "Tables 1A-1D provide exemplary iRNA agents targeting alpha-ENaC, based on the standard nomenclature abbreviations given in Table A.", "Table 1A, Seq Id No.s 305-608, Table 1B and Table 1D, Seq Id No.s 1519-1644 list siRNAs that do not comprise nucleotide modifications except for one phosphorothioate linkage between the 3′-terminal and the penultimate thymidines.", "The remaining Seq Ids in Tables 1A-1D lists siRNAs wherein all nucleotides comprising pyrimidine bases are 2′-O-methyl-modified nucleotides in the sense strand, and all uridines in a sequence context of 5′-ua-3′ as well as all cytidines in a sequence context of or 5′-ca-3′ are 2′-O-methyl-modified nucleotides in the antisense strand.", "Based on these results, the invention specifically provides an iRNA agent that includes a sense strand having at least 15 contiguous nucleotides of the sense strand sequences of the agents provided in Tables 1A-1D, and an antisense strand having at least 15 contiguous nucleotides of the antisense sequences of the agents provided in Tables 1A-1D.", "The iRNA agents shown in Tables 1A-1D are composed of two strands of 19 nucleotides in length which are complementary or identical to the target sequence, plus a 3′-TT overhang.", "The present invention provides agents that comprise at least 15, or at least 16, 17, or 18, or 19 contiguous nucleotides from these sequences.", "However, while these lengths may potentially be optimal, the iRNA agents are not meant to be limited to these lengths.", "The skilled person is well aware that shorter or longer iRNA agents may be similarly effective, since, within certain length ranges, the efficacy is rather a function of the nucleotide sequence than strand length.", "For example, Yang, et al., PNAS 99:9942-9947 (2002), demonstrated similar efficacies for iRNA agents of lengths between 21 and 30 base pairs.", "Others have shown effective silencing of genes by iRNA agents down to a length of approx.", "15 base pairs (Byrom, et al., “Inducing RNAi with siRNA Cocktails Generated by RNase III” Tech Notes 10(1), Ambion, Inc., Austin, Tex.).", "Therefore, it is possible and contemplated by the instant invention to select from the sequences provided in Tables 1A-1D a partial sequence of between 15 to 19 nucleotides for the generation of an iRNA agent derived from one of the sequences provided in Tables 1A-1D.", "Alternatively, one may add one or several nucleotides to one of the sequences provided in Tables 1A-1D, or an agent comprising 15 contiguous nucleotides from one of these agents, preferably, but not necessarily, in such a fashion that the added nucleotides are complementary to the respective sequence of the target gene, e.g., alpha-ENaC.", "For example, the first 15 nucleotides from one of the agents can be combined with the 8 nucleotides found 5′ to these sequence in alpha-ENaC mRNA to obtain an agent with 23 nucleotides in the sense and antisense strands.", "All such derived iRNA agents are included in the iRNA agents of the present invention, provided they essentially retain the ability to inhibit alpha-ENaC replication in cultured human cells.", "The antisense strand of an iRNA agent should be equal to or at least, 14, 15, 16, 17, 18, 19, 25, 29, 40, or 50 nucleotides in length.", "It should be equal to or less than 60, 50, 40, or 30, nucleotides in length.", "Preferred ranges are 15-30, 17 to 25, 19 to 23, and 19 to 21 nucleotides in length.", "The sense strand of an iRNA agent should be equal to or at least 14, 15, 16 17, 18, 19, 25, 29, 40, or 50 nucleotides in length.", "It should be equal to or less than 60, 50, 40, or 30 nucleotides in length.", "Preferred ranges are 15-30, 17 to 25, 19 to 23, and 19 to 21 nucleotides in length.", "The double stranded portion of an iRNA agent should be equal to or at least, 15, 16 17, 18, 19, 20, 21, 22, 23, 24, 25, 29, 40, or 50 nucleotide pairs in length.", "It should be equal to or less than 60, 50, 40, or 30 nucleotides pairs in length.", "Preferred ranges are 15-30, 17 to 25, 19 to 23, and 19 to 21 nucleotides pairs in length.", "Generally, the iRNA agents of the instant invention include a region of sufficient complementarity to the alpha-ENaC mRNA, and are of sufficient length in terms of nucleotides, that the iRNA agent, or a fragment thereof, can mediate down regulation of the alpha-ENaC gene.", "It is not necessary that there be perfect complementarity between the iRNA agent and the target gene, but the correspondence must be sufficient to enable the iRNA agent, or a cleavage product thereof, to direct sequence specific silencing, e.g., by RNAi cleavage of an alpha-ENaC mRNA.", "Therefore, the iRNA agents of the instant invention include agents comprising a sense strand and antisense strand each comprising a sequence of at least 16, 17 or 18 nucleotides which is essentially identical, as defined below, to one of the sequences of Tables 1A-1D, except that not more than 1, 2 or 3 nucleotides per strand, respectively, have been substituted by other nucleotides (e.g.", "adenosine replaced by uracil), while essentially retaining the ability to inhibit alpha-ENaC expression in cultured human cells.", "These agents will therefore possess at least 15 nucleotides identical to one of the sequences of Tables 1A-1D, but 1, 2 or 3 base mismatches with respect to either the target alpha-ENaC sequence or between the sense and antisense strand are introduced.", "Mismatches to the target alpha-ENaC RNA sequence, particularly in the antisense strand, are most tolerated in the terminal regions and if present are preferably in a terminal region or regions, e.g., within 6, 5, 4, or 3 nucleotides of a 5′ and/or 3′ terminus, most preferably within 6, 5, 4, or 3 nucleotides of the 5′-terminus of the sense strand or the 3′-terminus of the antisense strand.", "The sense strand need only be sufficiently complementary with the antisense strand to maintain the overall double stranded character of the molecule.", "It is preferred that the sense and antisense strands be chosen such that the iRNA agent includes a single strand or unpaired region at one or both ends of the molecule.", "Thus, an iRNA agent contains sense and antisense strands, preferably paired to contain an overhang, e.g., one or two 5′ or 3′ overhangs but preferably a 3′ overhang of 2-3 nucleotides.", "Most embodiments will have a 3′ overhang.", "Preferred siRNA agents will have single-stranded overhangs, preferably 3′ overhangs, of 1 to 4, or preferably 2 or 3 nucleotides, in length, at one or both ends of the iRNA agent.", "The overhangs can be the result of one strand being longer than the other, or the result of two strands of the same length being staggered.", "The unpaired nucleotides forming the overhang can be ribonucleotides, or they can be deoxyribonucleotides, preferably thymidine.", "5′-ends are preferably phosphorylated, or they may be unphosphorylated.", "Preferred lengths for the duplexed region are between 15 and 30, most preferably 18, 19, 20, 21, 22, and 23 nucleotides in length, e.g., in the siRNA agent range discussed above.", "siRNA agents can resemble in length and structure the natural Dicer processed products from long dsRNAs.", "Embodiments in which the two strands of the siRNA agent are linked, e.g., covalently linked, are also included.", "Hairpin, or other single strand structures which provide the required double stranded region, and preferably a 3′ overhang are also within the invention.", "Evaluation of Candidate iRNA Agents As noted above, the present invention provides a system for identifying siRNAs that are useful as inhibitors of alpha-ENaC.", "Since, as noted above, shRNAs are processed intracellularly to produce siRNAs having duplex portions with the same sequence as the stem structure of the shRNA, the system is equally useful for identifying shRNAs that are useful as inhibitors of alpha-ENaC.", "For purposes of description this section will refer to siRNAs, but the system also encompasses corresponding shRNAs.", "Specifically, the present invention demonstrates the successful preparation of siRNAs targeted to inhibit alpha-ENaC activity.", "The techniques and reagents described herein can readily be applied to design potential new siRNAs, targeted to other genes or gene regions, and tested for their activity in inhibiting alpha-ENaC as discussed herein.", "In various embodiments of the invention potential alpha-ENaC inhibitors can be tested for suppression of endogenous alpha-ENaC expression by introducing candidate siRNA(s) into cells (e.g., by exogenous administration or by introducing a vector or construct that directs endogenous synthesis of siRNA into the cell), or in laboratory animals by pulmonary or nasal administration.", "Alternately, potential alpha-ENaC inhibitors can be tested in vitro by transient co-transfection of candidate siRNA(s) together with an alpha-ENaC-expression plasmid.", "The ability of the candidate siRNA(s) to reduce target transcript levels and/or to inhibit or suppress one or more aspects or features of alpha-ENaC activity such as epithelial potential difference or airway surface fluid absorption is then assessed.", "Cells or laboratory animals to which inventive siRNA compositions have been delivered (test cells/animals) may be compared with similar or comparable cells or laboratory animals that have not received the inventive composition (control cells/animals, e.g., cells/animals that have received either no siRNA or a control siRNA such as an siRNA targeted to a non-endogenous transcript such as green fluorescent protein (GFP)).", "The ion transport phenotype of the test cells/animals can be compared with the phenotype of control cells/animals, providing that the inventive siRNA share sequence cross-reactivity with the test cell type/species.", "Production of alpha-ENaC protein and short circuit current (in vitro or ex vivo) may be compared in the test cells/animals relative to the control cells/animals.", "Other indicia of alpha-ENaC activity, including ex vivo epithelial potential difference or in vivo mucocilliary clearance or whole body magnetic resonance imaging (MRI), can be similarly compared.", "Generally, test cells/animals and control cells/animals would be from the same species and, for cells, of similar or identical cell type.", "For example, cells from the same cell line could be compared.", "When the test cell is a primary cell, typically the control cell would also be a primary cell.", "For example, the ability of a candidate siRNA to inhibit alpha-ENaC activity may conveniently be determined by (i) delivering the candidate siRNA to cells (ii) assessing the expression levels of alpha-ENaC mRNA relative to an endogenously expressed control gene (iii) comparing the amiloride-sensitive current in an in vitro cell model produced in the presence of the siRNA with the amount produced in the absence of the siRNA.", "This latter assay may be used to test siRNAs that target any target transcript that may influence alpha-ENaC activity indirectly and is not limited to siRNAs that target the transcripts that encode the ENaC channel subunits.", "The ability of a candidate siRNA to reduce the level of the target transcript may be assessed by measuring the amount of the target transcript using, for example, Northern blots, nuclease protection assays, probe hybridization, reverse transcription (RT)-PCR, real-time RT-PCR, microarray analysis, etc.", "The ability of a candidate siRNA to inhibit production of a polypeptide encoded by the target transcript (either at the transcriptional or post-transcriptional level) may be measured using a variety of antibody-based approaches including, but not limited to, Western blots, immunoassays, ELISA, flow cytometry, protein microarrays, etc.", "In general, any method of measuring the amount of either the target transcript or a polypeptide encoded by the target transcript may be used.", "In general, certain preferred alpha-ENaC iRNA inhibitors reduce the target transcript level at least about 2 fold, preferably at least about 4 fold, more preferably at least about 8 fold, at least about 16 fold, at least about 64 fold or to an even greater degree relative to the level that would be present in the absence of the inhibitor (e.g., in a comparable control cell lacking the inhibitor).", "In general, certain preferred alpha-ENaC iRNA inhibitors inhibit ENaC channel activity, so that the activity is lower in a cell containing the inhibitor than in a control cell not containing the inhibitor by at least about 2 fold, preferably at least about 4 fold, more preferably at least about 8 fold, at least about 16 fold, at least about 64 fold, at least about 100 fold, at least about 200 fold, or to an even greater degree.", "Certain preferred alpha-ENaC iRNA inhibitors inhibit ENaC channel activity for at least 12 hours, at least 24 hours, at least 36 hours, at least 48 hours, at least 60 hours, at least 72 hours, at least 96 hours, at least 120 hours, at least 144 hours or at least 168 hours following administration of the siRNA and infection of the cells.", "Certain preferred alpha-ENaC inhibitors prevent (i.e., reduce to undetectable levels) or significantly reduce alpha-ENaC activity for at least 24 hours, at least 36 hours, at least 48 hours, or at least 60 hours following administration of the siRNA.", "According to various embodiments of the invention a significant reduction in alpha-ENaC activity is a reduction to less than approximately 90% of the level that would occur in the absence of the siRNA, a reduction to less than approximately 75% of the level that would occur in the absence of the siRNA, a reduction to less than approximately 50% of the level that would occur in the absence of the siRNA, a reduction to less than approximately 25% of the level that would occur in the absence of the siRNA, or a reduction to less than approximately 10% of the level that would occur in the absence of the siRNA.", "Reduction in alpha-ENaC activity may be measured using any suitable method including, but not limited to, short circuit current measurement of amiloride sensitivity in vitro, epithelial potential difference ex vivo or in vivo mucocilliary clearance or whole body/lung MRI.", "Stability Testing, Modification, and Retesting of iRNA Agents A candidate iRNA agent can be evaluated with respect to stability, e.g., its susceptibility to cleavage by an endonuclease or exonuclease, such as when the iRNA agent is introduced into the body of a subject.", "Methods can be employed to identify sites that are susceptible to modification, particularly cleavage, e.g., cleavage by a component found in the body of a subject.", "Such methods may include the isolation and identification of most abundant fragments formed by degradation of the candidate iRNA agent after its incubation with isolated biological media in vitro, e.g.", "serum, plasma, sputum, cerebrospinal fluid, or cell or tissue homogenates, or after contacting a subject with the candidate iRNA agent in vivo, thereby identifying sites prone to cleavage.", "Such methods are, for example, without limitation, in International Patent Application Publication No.", "WO2005115481, filed on May 27, 2005.When sites susceptible to cleavage are identified, a further iRNA agent can be designed and/or synthesized wherein the potential cleavage site is made resistant to cleavage, e.g.", "by introduction of a 2′-modification on the site of cleavage, e.g.", "a 2′-O-methyl group.", "This further iRNA agent can be retested for stability, and this process may be iterated until an iRNA agent is found exhibiting the desired stability.", "In Vivo Testing An iRNA agent identified as being capable of inhibiting alpha-ENaC gene expression can be tested for functionality in vivo in an animal model (e.g., in a mammal, such as in mouse, rat, guinea-pig or primate).", "For example, the iRNA agent can be administered to an animal, and the iRNA agent evaluated with respect to its biodistribution, stability, and its ability to inhibit alpha-ENaC expression or modulate a biological or pathological process mediated at least in part by alpha-ENaC.", "The iRNA agent can be administered directly to the target tissue, such as by injection, or the iRNA agent can be administered to the animal model in the same manner that it would be administered to a human.", "Preferably, the iRNA agent is delivered to the subject's airways, such as by intranasal, inhaled or intratracheal administration.", "The iRNA agent can also be evaluated for its intracellular distribution.", "The evaluation can include determining whether the iRNA agent was taken up into the cell.", "The evaluation can also include determining the stability (e.g., the half-life) of the iRNA agent.", "Evaluation of an iRNA agent in vivo can be facilitated by use of an iRNA agent conjugated to a traceable marker (e.g., a fluorescent marker such as fluorescein; a radioactive label, such as 35S, 32P, 33P, or 3H; gold particles; or antigen particles for immunohistochemistry).", "The iRNA agent can be evaluated with respect to its ability to down regulate alpha-alpha-ENaC expression.", "Levels of alpha-ENaC gene expression in vivo can be measured, for example, by in situ hybridization, or by the isolation of RNA from tissue prior to and following exposure to the iRNA agent.", "Where the animal needs to be sacrificed in order to harvest the tissue, an untreated control animal will serve for comparison.", "alpha-ENaC RNA can be detected by any desired method, including but not limited to RT-PCR, northern blot, branched-DNA assay, or RNAase protection assay.", "Alternatively, or additionally, alpha-ENaC gene expression can be monitored by performing western blot analysis or immunostaining on tissue extracts treated with the iRNA agent.", "Potential alpha-ENaC inhibitors can be tested using any variety of animal models that have been developed.", "Compositions comprising candidate siRNA(s), constructs or vectors capable of directing synthesis of such siRNAs within a host cell, or cells engineered or manipulated to contain candidate siRNAs may be administered to an animal.", "The ability of the composition to suppress alpha-ENaC expression and/or to modify ENaC-dependent phenotypes and/or lessen their severity relative to animals that have not received the potential alpha-ENaC inhibitor is assessed.", "Such models include, but are not limited to, murine, rat, guinea pig, sheep and non-human primate models for ENaC-dependent phenotypes, all of which are known in the art and are used for testing the efficacy of potential alpha-ENaC therapeutics.", "Utilising the systems invented for identifying candidate therapeutic siRNA agents, suitable therapeutic agents are selected from Duplex identifiers ND-8302, ND-8332, ND-8348, ND-8356, ND-8357, ND-8373, ND-8381, ND-8396, ND-8450 and ND-8453, more suitably selected from ND-8356, ND-8357 and ND-8396.iRNA Chemistry Described herein are isolated iRNA agents, e.g., ds RNA agents that mediate RNAi to inhibit expression of the alpha-ENaC gene.", "RNA agents discussed herein include otherwise unmodified RNA as well as RNA which has been modified, e.g., to improve efficacy, and polymers of nucleoside surrogates.", "Unmodified RNA refers to a molecule in which the components of the nucleic acid, namely sugars, bases, and phosphate moieties, are the same or essentially the same as that which occur in nature, preferably as occur naturally in the human body.", "The art has referred to rare or unusual, but naturally occurring, RNAs as modified RNAs, see, e.g., Limbach et al.", "Nucleic Acids Res.", "22: 2183-2196, 1994.Such rare or unusual RNAs, often termed modified RNAs (apparently because they are typically the result of a post-transcriptional modification) are within the term unmodified RNA, as used herein.", "Modified RNA as used herein refers to a molecule in which one or more of the components of the nucleic acid, namely sugars, bases, and phosphate moieties, are different from that which occurs in nature, preferably different from that which occurs in the human body.", "While they are referred to as modified “RNAs,” they will of course, because of the modification, include molecules which are not RNAs.", "Nucleoside surrogates are molecules in which the ribophosphate backbone is replaced with a non-ribophosphate construct that allows the bases to the presented in the correct spatial relationship such that hybridization is substantially similar to what is seen with a ribophosphate backbone, e.g., non-charged mimics of the ribophosphate backbone.", "Examples of the above are discussed herein.", "Modifications described herein can be incorporated into any double-stranded RNA and RNA-like molecule described herein, e.g., an iRNA agent.", "It may be desirable to modify one or both of the antisense and sense strands of an iRNA agent.", "As nucleic acids are polymers of subunits or monomers, many of the modifications described below occur at a position which is repeated within a nucleic acid, e.g., a modification of a base, or a phosphate moiety, or the non-linking oxygen of a phosphate moiety.", "In some cases the modification will occur at all of the subject positions in the nucleic acid but in many, and in fact in most, cases it will not.", "By way of example, a modification may only occur at a 3′ or 5′ terminal position, may only occur in a terminal region, e.g.", "at a position on a terminal nucleotide or in the last 2, 3, 4, 5, or 10 nucleotides of a strand.", "A modification may occur in a double strand region, a single strand region, or in both.", "E.g., a phosphorothioate modification at a non-linking 0 position may only occur at one or both termini, may only occur in a terminal regions, e.g., at a position on a terminal nucleotide or in the last 2, 3, 4, 5, or 10 nucleotides of a strand, or may occur in double strand and single strand regions, particularly at termini.", "Similarly, a modification may occur on the sense strand, antisense strand, or both.", "In some cases, the sense and antisense strand will have the same modifications or the same class of modifications, but in other cases the sense and antisense strand will have different modifications, e.g., in some cases it may be desirable to modify only one strand, e.g.", "the sense strand.", "Two prime objectives for the introduction of modifications into iRNA agents is their stabilization towards degradation in biological environments and the improvement of pharmacological properties, e.g.", "pharmacodynamic properties, which are further discussed below.", "Other suitable modifications to a sugar, base, or backbone of an iRNA agent are described in PCT Application No.", "PCT/US2004/01193, filed Jan. 16, 2004.An iRNA agent can include a non-naturally occurring base, such as the bases described in PCT Application No.", "PCT/US2004/011822, filed Apr.", "16, 2004.An iRNA agent can include a non-naturally occurring sugar, such as a non-carbohydrate cyclic carrier molecule.", "Exemplary features of non-naturally occurring sugars for use in iRNA agents are described in PCT Application No.", "PCT/US2004/11829, filed Apr.", "16, 2003.An iRNA agent can include an internucleotide linkage (e.g., the chiral phosphorothioate linkage) useful for increasing nuclease resistance.", "In addition, or in the alternative, an iRNA agent can include a ribose mimic for increased nuclease resistance.", "Exemplary internucleotide linkages and ribose mimics for increased nuclease resistance are described in PCT Application No.", "PCT/US2004/07070, filed on Mar.", "8, 2004.An iRNA agent can include ligand-conjugated monomer subunits and monomers for oligonucleotide synthesis.", "Exemplary monomers are described in U.S. application Ser.", "No.", "10/916,185, filed on Aug. 10, 2004.An iRNA agent can have a ZXY structure, such as is described in PCT Application No.", "PCT/US2004/07070, filed on Mar.", "8, 2004.An iRNA agent can be complexed with an amphipathic moiety.", "Exemplary amphipathic moieties for use with iRNA agents are described in PCT Application No.", "PCT/US2004/07070, filed on Mar.", "8, 2004.In another embodiment, the iRNA agent can be complexed to a delivery agent that features a modular complex.", "The complex can include a carrier agent linked to one or more of (preferably two or more, more preferably all three of): (a) a condensing agent (e.g., an agent capable of attracting, e.g., binding, a nucleic acid, e.g., through ionic or electrostatic interactions); (b) a fusogenic agent (e.g., an agent capable of fusing and/or being transported through a cell membrane); and (c) a targeting group, e.g., a cell or tissue targeting agent, e.g., a lectin, glycoprotein, lipid or protein, e.g., an antibody, that binds to a specified cell type.", "iRNA agents complexed to a delivery agent are described in PCT Application No.", "PCT/US2004/07070, filed on Mar.", "8, 2004.An iRNA agent can have non-canonical pairings, such as between the sense and antisense sequences of the iRNA duplex.", "Exemplary features of non-canonical iRNA agents are described in PCT Application No.", "PCT/US2004/07070, filed on Mar.", "8, 2004.Enhanced Nuclease Resistance An iRNA agent, e.g., an iRNA agent that targets alpha-ENaC, can have enhanced resistance to nucleases.", "One way to increase resistance is to identify cleavage sites and modify such sites to inhibit cleavage, as described in U.S.", "Application No.", "60/559,917, filed on May 4, 2004.For example, the dinucleotides 5′-ua-3′, 5′-ca-3′, 5′-ug-3′, 5′-uu-3′, or 5′-cc-3′ can serve as cleavage sites.", "In certain embodiments, all the pyrimidines of an iRNA agent carry a 2′-modification in either the sense strand, the antisense strand, or both strands, and the iRNA agent therefore has enhanced resistance to endonucleases.", "Enhanced nuclease resistance can also be achieved by modifying the 5′ nucleotide, resulting, for example, in at least one 5′-uridine-adenine-3′ (5′-ua-3′) dinucleotide wherein the uridine is a 2′-modified nucleotide; at least one 5′-cytidine-adenine-3′ (5′-ca-3′) dinucleotide, wherein the 5′-cytidine is a 2′-modified nucleotide; at least one 5′-uridine-guanine-3′ (5′-ug-3′) dinucleotide, wherein the 5′-uridine is a 2′-modified nucleotide; at least one 5′-uridine-uridine-3′ (5′-uu-3′) dinucleotide, wherein the 5′-uridine is a 2′-modified nucleotide; or at least one 5′-cytidine-cytidine-3′ (5′-cc-3′) dinucleotide, wherein the 5′-cytidine is a 2′-modified nucleotide, as described in International Application No.", "PCT/US2005/018931, filed on May 27, 2005.The iRNA agent can include at least 2, at least 3, at least 4 or at least 5 of such dinucleotides.", "In a particularly preferred embodiment, the 5′ nucleotide in all occurrences of the sequence motifs 5′-ua-3′ and 5′-ca-3′ in either the sense strand, the antisense strand, or both strands is a modified nucleotide.", "Preferably, the 5′ nucleotide in all occurrences of the sequence motifs 5′-ua-3′, 5′-ca-3′ and 5′-ug-3′ in either the sense strand, the antisense strand, or both strands is a modified nucleotide.", "More preferably, all pyrimidine nucleotides in the sense strand are modified nucleotides, and the 5′ nucleotide in all occurrences of the sequence motifs 5′-ua-3′ and 5′-ca-3′ in the antisense strand are modified nucleotides, or where the antisense strand does comprise neither of a 5′-ua-3′ and a 5′-ca-3′ motif, in all occurrences of the sequence motif 5′-ug-3′.", "Preferably, the 2′-modified nucleotides include, for example, a 2′-modified ribose unit, e.g., the 2′-hydroxyl group (OH) can be modified or replaced with a number of different “oxy” or “deoxy” substituents.", "Examples of “oxy”-2′ hydroxyl group modifications include alkoxy or aryloxy (OR, e.g., R═H, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl or sugar); polyethyleneglycols (PEG), O(CH2CH2O)nCH2CH2OR; “locked” nucleic acids (LNA) in which the 2′ hydroxyl is connected, e.g., by a methylene bridge, to the 4′ carbon of the same ribose sugar; O-AMINE and aminoalkoxy, O(CH2)nAMINE, (e.g., AMINE=NH2; alkylamino, dialkylamino, heterocyclyl amino, arylamino, diaryl amino, heteroaryl amino, or diheteroaryl amino, ethylene diamine, polyamino).", "It is noteworthy that oligonucleotides containing only the methoxyethyl group (MOE), (OCH2CH2OCH3, a PEG derivative), exhibit nuclease stabilities comparable to those modified with the robust phosphorothioate modification.", "“Deoxy” modifications include hydrogen (i.e.", "deoxyribose sugars, which are of particular relevance to the overhang portions of partially ds RNA); halo (e.g., fluoro); amino (e.g.", "NH2; alkylamino, dialkylamino, heterocyclyl, arylamino, diaryl amino, heteroaryl amino, diheteroaryl amino, or amino acid); NH(CH2CH2NH)nCH2CH2-AMINE (AMINE=NH2; alkylamino, dialkylamino, heterocyclyl amino, arylamino, diaryl amino, heteroaryl amino, or diheteroaryl amino), —NHC(O)R (R=alkyl, cycloalkyl, aryl, aralkyl, heteroaryl or sugar), cyano; mercapto; alkyl-thio-alkyl; thioalkoxy; and alkyl, cycloalkyl, aryl, alkenyl and alkynyl, which may be optionally substituted with e.g., an amino functionality.", "Preferred substitutents are 2′-methoxyethyl, 2′-OCH3, 2′-O-allyl, 2′-C— allyl, and 2′-fluoro.", "The inclusion of furanose sugars in the oligonucleotide backbone can also decrease endonucleolytic cleavage.", "An iRNA agent can be further modified by including a 3′ cationic group, or by inverting the nucleoside at the 3′-terminus with a 3′-3′ linkage.", "In another alternative, the 3′-terminus can be blocked with an aminoalkyl group, e.g., a 3′ C5-aminoalkyl dT.", "Other 3′ conjugates can inhibit 3′-5′ exonucleolytic cleavage.", "While not being bound by theory, a 3′ conjugate, such as naproxen or ibuprofen, may inhibit exonucleolytic cleavage by sterically blocking the exonuclease from binding to the 3′-end of oligonucleotide.", "Even small alkyl chains, aryl groups, or heterocyclic conjugates or modified sugars (D-ribose, deoxyribose, glucose etc.)", "can block 3′-5′-exonucleases.", "Nucleolytic cleavage can also be inhibited by the introduction of phosphate linker modifications, e.g., phosphorothioate linkages.", "Thus, preferred iRNA agents include nucleotide dimers enriched or pure for a particular chiral form of a modified phosphate group containing a heteroatom at a nonbridging position normally occupied by oxygen.", "The heteroatom can be S, Se, Nr2, or Br3.When the heteroatom is S, enriched or chirally pure Sp linkage is preferred.", "Enriched means at least 70, 80, 90, 95, or 99% of the preferred form.", "Modified phosphate linkages are particularly efficient in inhibiting exonucleolytic cleavage when introduced near the 5′- or 3′-terminal positions, and preferably the 5′-terminal positions, of an iRNA agent.", "5′ conjugates can also inhibit 5′-3′ exonucleolytic cleavage.", "While not being bound by theory, a 5′ conjugate, such as naproxen or ibuprofen, may inhibit exonucleolytic cleavage by sterically blocking the exonuclease from binding to the 5′-end of oligonucleotide.", "Even small alkyl chains, aryl groups, or heterocyclic conjugates or modified sugars (D-ribose, deoxyribose, glucose etc.)", "can block 3′-5′-exonucleases.", "An iRNA agent can have increased resistance to nucleases when a duplexed iRNA agent includes a single-stranded nucleotide overhang on at least one end.", "In preferred embodiments, the nucleotide overhang includes 1 to 4, preferably 2 to 3, unpaired nucleotides.", "In a preferred embodiment, the unpaired nucleotide of the single-stranded overhang that is directly adjacent to the terminal nucleotide pair contains a purine base, and the terminal nucleotide pair is a G-C pair, or at least two of the last four complementary nucleotide pairs are G-C pairs.", "In further embodiments, the nucleotide overhang may have 1 or 2 unpaired nucleotides, and in an exemplary embodiment the nucleotide overhang is 5′-gc-3′.", "In preferred embodiments, the nucleotide overhang is on the 3′-end of the antisense strand.", "In one embodiment, the iRNA agent includes the motif 5′-cgc-3′ on the 3′-end of the antisense strand, such that a 2-nt overhang 5′-gc-3′ is formed.", "Thus, an iRNA agent can include modifications so as to inhibit degradation, e.g., by nucleases, e.g., endonucleases or exonucleases, found in the body of a subject.", "These monomers are referred to herein as NRMs, or Nuclease Resistance promoting Monomers, the corresponding modifications as NRM modifications.", "In many cases these modifications will modulate other properties of the iRNA agent as well, e.g., the ability to interact with a protein, e.g., a transport protein, e.g., serum albumin, or a member of the RISC, or the ability of the first and second sequences to form a duplex with one another or to form a duplex with another sequence, e.g., a target molecule.", "One or more different NRM modifications can be introduced into an iRNA agent or into a sequence of an iRNA agent.", "An NRM modification can be used more than once in a sequence or in an iRNA agent.", "NRM modifications include some which can be placed only at the terminus and others which can go at any position.", "Some NRM modifications can inhibit hybridization so it is preferable to use them only in terminal regions, and preferable to not use them at the cleavage site or in the cleavage region of a sequence which targets a subject sequence or gene, particularly on the antisense strand.", "They can be used anywhere in a sense strand, provided that sufficient hybridization between the two strands of the ds iRNA agent is maintained.", "In some embodiments it is desirable to put the NRM at the cleavage site or in the cleavage region of a sense strand, as it can minimize off-target silencing.", "In most cases, NRM modifications will be distributed differently depending on whether they are comprised on a sense or antisense strand.", "If on an antisense strand, modifications which interfere with or inhibit endonuclease cleavage should not be inserted in the region which is subject to RISC mediated cleavage, e.g., the cleavage site or the cleavage region (As described in Elbashir et al., 2001, Genes and Dev.", "15: 188, hereby incorporated by reference).", "Cleavage of the target occurs about in the middle of a 20 or 21 nt antisense strand, or about 10 or 11 nucleotides upstream of the first nucleotide on the target mRNA which is complementary to the antisense strand.", "As used herein cleavage site refers to the nucleotides on either side of the cleavage site, on the target or on the iRNA agent strand which hybridizes to it.", "Cleavage region means the nucleotides within 1, 2, or 3 nucleotides of the cleavagee site, in either direction.", "Such modifications can be introduced into the terminal regions, e.g., at the terminal position or with 2, 3, 4, or 5 positions of the terminus, of a sense or antisense strand.", "Tethered Ligands The properties of an iRNA agent, including its pharmacological properties, can be influenced and tailored, for example, by the introduction of ligands, e.g.", "tethered ligands.", "In addition, pharmacological properties of an iRNA agent can be improved by incorporating a ligand in a formulation of the iRNA agent when the iRNA agent either has or does have a tethered ligand.", "A wide variety of entities, e.g., ligands, can be tethered to an iRNA agent or used as formluation conjugate or additive, e.g., to the carrier of a ligand-conjugated monomer subunit.", "Examples are described below in the context of a ligand-conjugated monomer subunit but that is only preferred, entities can be coupled at other points to an iRNA agent.", "Preferred moieties are ligands, which are coupled, preferably covalently, either directly or indirectly, via an intervening tether to the carrier.", "In preferred embodiments, the ligand is attached to the carrier via an intervening tether.", "The ligand or tethered ligand may be present on the ligand-conjugated monomer when the ligand-conjugated monomer is incorporated into the growing strand.", "In some embodiments, the ligand may be incorporated into a “precursor” ligand-conjugated monomer subunit after a “precursor” ligand-conjugated monomer subunit has been incorporated into the growing strand.", "For example, a monomer having, e.g., an amino-terminated tether, e.g., TAP-(CH2)nNH2 may be incorporated into a growing sense or antisense strand.", "In a subsequent operation, i.e., after incorporation of the precursor monomer subunit into the strand, a ligand having an electrophilic group, e.g., a pentafluorophenyl ester or aldehyde group, can subsequently be attached to the precursor ligand-conjugated monomer by coupling the electrophilic group of the ligand with the terminal nucleophilic group of the precursor ligand-conjugated monomer subunit tether.", "In preferred embodiments, a ligand alters the distribution, targeting or lifetime of an iRNA agent into which it is incorporated.", "In preferred embodiments a ligand provides an enhanced affinity for a selected target, e.g., molecule, cell or cell type, compartment, e.g., a cellular or organ compartment, tissue, organ or region of the body, as, e.g., compared to a species absent such a ligand.", "Preferred ligands can improve transport, hybridization, and specificity properties and may also improve nuclease resistance of the resultant natural or modified oligoribonucleotide, or a polymeric molecule comprising any combination of monomers described herein and/or natural or modified ribonucleotides.", "Ligands in general can include therapeutic modifiers, e.g., for enhancing uptake; diagnostic compounds or reporter groups e.g., for monitoring distribution; cross-linking agents; nuclease-resistance conferring moieties; and natural or unusual nucleobases.", "General examples include lipophilic molecules, lipids, lectins, steroids (e.g., uvaol, hecigenin, diosgenin), terpenes (e.g., triterpenes, e.g., sarsasapogenin, Friedelin, epifriedelanol derivatized lithocholic acid), vitamins, carbohydrates (e.g., a dextran, pullulan, chitin, chitosan, synthetic (eg Oligo Lactate 15-mer) and natural (eg low and medium molecular weight) polymers, inulin, cyclodextrin or hyaluronic acid), proteins, protein binding agents, integrin targeting molecules, polycationics, peptides, polyamines, and peptide mimics.", "Other examples include folic acid or epithelial cell receptor ligands, such as transferin.", "The ligand may be a naturally occurring or recombinant or synthetic molecule, such as a synthetic polymer, e.g., a synthetic polyamino acid.", "Examples of polyamino acids include polylysine (PLL), poly L-aspartic acid, poly L-glutamic acid, styrene-maleic acid anhydride copolymer, poly(L-lactide-co-glycolied) copolymer, divinyl ether-maleic anhydride copolymer, N-(2-hydroxypropyl)methacrylamide copolymer (HMPA), polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyurethane, poly(2-ethylacrylic acid), N-isopropylacrylamide polymers, or polyphosphazine.", "Example of polyamines include: polyethylenimine, polylysine (PLL), spermine, spermidine, polyamine, pseudopeptide-polyamine, peptidomimetic polyamine, dendrimer polyamine, arginine, amidine, protamine, cationic moieties, e.g., cationic lipid, cationic porphyrin, quaternary salt of a polyamine, or an alpha helical peptide.", "Ligands can also include targeting groups, e.g., a cell or tissue targeting agent, e.g., a thyrotropin, melanotropin, surfactant protein A, mucin carbohydrate, a glycosylated polyaminoacid, transferrin, bisphosphonate, polyglutamate, polyaspartate, or an Arg-Gly-Asp (RGD) peptide or RGD peptide mimetic.", "Ligands can be proteins, e.g., glycoproteins, lipoproteins, e.g.", "low density lipoprotein (LDL), or albumins, e.g.", "human serum albumin (HSA), or peptides, e.g., molecules having a specific affinity for a co-ligand, or antibodies e.g., an antibody, that binds to a specified cell type such as a cancer cell, endothelial cell, or bone cell.", "Ligands may also include hormones and hormone receptors.", "They can also include non-peptidic species, such as cofactors, multivalent lactose, multivalent galactose, N-acetyl-galactosamine, N-acetyl-glucosamine, multivalent mannose, or multivalent fucose.", "The ligand can be a substance, e.g, a drug, which can increase the uptake of the iRNA agent into the cell, for example, by disrupting the cell's cytoskeleton, e.g., by disrupting the cell's microtubules, microfilaments, and/or intermediate filaments.", "The drug can be, for example, taxon, vincristine, vinblastine, cytochalasin, nocodazole, japlakinolide, latrunculin A, phalloidin, swinholide A, indanocine, myoservin, tetracyclin.", "In one aspect, the ligand is a lipid or lipid-based molecule.", "Such a lipid or lipid-based molecule preferably binds a serum protein, e.g., human serum albumin (HSA).", "An HSA binding ligand allows for distribution of the conjugate to a target tissue, e.g., liver tissue, including parenchymal cells of the liver.", "Other molecules that can bind HSA can also be used as ligands.", "For example, neproxin or aspirin can be used.", "A lipid or lipid-based ligand can (a) increase resistance to degradation of the conjugate, (b) increase targeting or transport into a target cell or cell membrane, and/or (c) can be used to adjust binding to a serum protein, e.g., HSA.", "A lipid based ligand can be used to modulate, e.g., control the binding of the conjugate to a target tissue.", "For example, a lipid or lipid-based ligand that binds to HSA more strongly will be less likely to be targeted to the kidney and therefore less likely to be cleared from the body.", "In a preferred embodiment, the lipid based ligand binds HSA.", "Preferably, it binds HSA with a sufficient affinity such that the conjugate will be preferably distributed to a non-kidney tissue.", "However, it is preferred that the affinity not be so strong that the HSA-ligand binding cannot be reversed.", "In another aspect, the ligand is a moiety, e.g., a vitamin or nutrient, which is taken up by a target cell, e.g., a proliferating cell.", "These are particularly useful for treating disorders characterized by unwanted cell proliferation, e.g., of the malignant or non-malignant type, e.g., cancer cells.", "Exemplary vitamins include vitamin A, E, and K. Other exemplary vitamins include the B vitamins, e.g., folic acid, B12, riboflavin, biotin, pyridoxal or other vitamins or nutrients taken up by cancer cells.", "In another aspect, the ligand is a cell-permeation agent, preferably a helical cell-permeation agent.", "Preferably, the agent is amphipathic.", "An exemplary agent is a peptide such as tat or antennapedia.", "If the agent is a peptide, it can be modified, including a peptidylmimetic, invertomers, non-peptide or pseudo-peptide linkages, and use of D-amino acids.", "The helical agent is preferably an alpha-helical agent, which preferably has a lipophilic and a lipophobic phase.", "The cell permeation agent can be linked covalently to the iRNA agent or be part of an iRNA-peptide complex.", "5′-Phosphate Modifications In preferred embodiments, iRNA agents are 5′ phosphorylated or include a phosphoryl analog at the 5′ prime terminus.", "5′-phosphate modifications of the antisense strand include those which are compatible with RISC-mediated gene silencing.", "Suitable modifications include: 5′-monophosphate ((HO)2(O)P—O-5′); 5′-diphosphate ((HO)2(O)P—O—P(HO)(O)—O-5′); 5′-triphosphate ((HO)2(O)P—O—(HO)(O)P—O—P(HO)(O)—O-5′); 5′-guanosine cap (7-methylated or non-methylated) (7m-G-O-5′-(HO)(O)P—O—(HO)(O)P—O—P(HO)(O)—O-5′); 5′-adenosine cap (Appp), and any modified or unmodified nucleotide cap structure (N—O-5′-(HO)(O)P—O—(HO)(O)P—O—P(HO)(O)—O-5′); 5′-monothiophosphate (phosphorothioate; (HO)2(S)P—O-5′); 5′-monodithiophosphate (phosphorodithioate; (HO)(HS)(S)P—O-5′), 5′-phosphorothiolate ((HO)2(O)P—S-5′); any additional combination of oxygen/sulfur replaced monophosphate, diphosphate and triphosphates (e.g.", "5′-alpha-thiotriphosphate, 5′-gamma-thiotriphosphate, etc.", "), 5′-phosphoramidates ((HO)2(O)P—NH-5′, (HO)(NH2)(O)P—O-5′), 5′-alkylphosphonates (R=alkyl=methyl, ethyl, isopropyl, propyl, etc., e.g.", "RP(OH)(O)—O-5′-, (OH)2(O)P-5′-CH2—), 5′-alkyletherphosphonates (R=alkylether=methoxymethyl (MeOCH2—), ethoxymethyl, etc., e.g.", "RP(OH)(O)—O-5′-).", "The sense strand can be modified in order to inactivate the sense strand and prevent formation of an active RISC, thereby potentially reducing off-target effects.", "This can be accomplished by a modification which prevents 5′-phosphorylation of the sense strand, e.g., by modification with a 5′-O-methyl ribonucleotide (see Nykänen et al., (2001) ATP requirements and small interfering RNA structure in the RNA interference pathway.", "Cell 107, 309-321.)", "Other modifications which prevent phosphorylation can also be used, e.g., simply substituting the 5′-OH by H rather than O-Me.", "Alternatively, a large bulky group may be added to the 5′-phosphate turning it into a phosphodiester linkage.", "Non-Natural Nucleobases Nitropyrrolyl and nitroindolyl are non-natural nucleobases that are members of a class of compounds known as universal bases.", "Universal bases are those compounds that can replace any of the four naturally occuring bases without substantially affecting the melting behavior or activity of the oligonucleotide duplex.", "In contrast to the stabilizing, hydrogen-bonding interactions associated with naturally occurring nucleobases, it is postulated that oligonucleotide duplexes containing 3-nitropyrrolyl nucleobases are stabilized solely by stacking interactions.", "The absence of significant hydrogen-bonding interactions with nitropyrrolyl nucleobases obviates the specificity for a specific complementary base.", "In addition, various reports confirm that 4-, 5- and 6-nitroindolyl display very little specificity for the four natural bases.", "Interestingly, an oligonucleotide duplex containing 5-nitroindolyl was more stable than the corresponding oligonucleotides containing 4-nitroindolyl and 6-nitroindolyl.", "Procedures for the preparation of 1-(2′-O-methyl-β-D-ribofuranosyl)-5-nitroindole are described in Gaubert, G.; Wengel, J. Tetrahedron Letters 2004, 45, 5629.Other universal bases amenable to the present invention include hypoxanthinyl, isoinosinyl, 2-aza-inosinyl, 7-deaza-inosinyl, nitroimidazolyl, nitropyrazolyl, nitrobenzimidazolyl, nitroindazolyl, aminoindolyl, pyrrolopyrimidinyl, and structural derivatives thereof.", "For a more detailed discussion, including synthetic procedures, of nitropyrrolyl, nitroindolyl, and other universal bases mentioned above see Vallone et al., Nucleic Acids Research, 27(17):3589-3596 (1999); Loakes et al., J. Mol.", "Bio., 270:426-436 (1997); Loakes et al., Nucleic Acids Research, 22(20):4039-4043 (1994); Oliver et al., Organic Letters, Vol.", "3(13):1977-1980 (2001); Amosova et al., Nucleic Acids Research, 25(10):1930-1934 (1997); Loakes et al., Nucleic Acids Research, 29(12):2437-2447 (2001); Bergstrom et al., J.", "Am.", "Chem.", "Soc., 117:1201-1209 (1995); Franchetti et al., Biorg.", "Med.", "Chem.", "Lett.", "11:67-69 (2001); and Nair et al., Nucelosides, Nucleotides & Nucleic Acids, 20(4-7):735-738 (2001).", "Difluorotolyl is a non-natural nucleobase that functions as a universal base.", "Difluorotolyl is an isostere of the natural nucleobase thymine.", "But unlike thymine, difluorotolyl shows no appreciable selectivity for any of the natural bases.", "Other aromatic compounds that function as universal bases and are amenable to the present invention are 4-fluoro-6-methylbenzimidazole and 4-methylbenzimidazole.", "In addition, the relatively hydrophobic isocarbostyrilyl derivatives 3-methyl isocarbostyrilyl, 5-methyl isocarbostyrilyl, and 3-methyl-7-propynyl isocarbostyrilyl are universal bases which cause only slight destabilization of oligonucleotide duplexes compared to the oligonucleotide sequence containing only natural bases.", "Other non-natural nucleobases contemplated in the present invention include 7-azaindolyl, 6-methyl-7-azaindolyl, imidizopyridinyl, 9-methyl-imidizopyridinyl, pyrrolopyrizinyl, isocarbostyrilyl, 7-propynyl isocarbostyrilyl, propynyl-7-azaindolyl, 2,4,5-trimethylphenyl, 4-methylindolyl, 4,6-dimethylindolyl, phenyl, napthalenyl, anthracenyl, phenanthracenyl, pyrenyl, stilbenyl, tetracenyl, pentacenyl, and structural derivates thereof.", "For a more detailed discussion, including synthetic procedures, of difluorotolyl, 4-fluoro-6-methylbenzimidazole, 4-methylbenzimidazole, and other non-natural bases mentioned above, see: Schweitzer et al., J. Org.", "Chem., 59:7238-7242 (1994); Berger et al., Nucleic Acids Research, 28(15):2911-2914 (2000); Moran et al., J.", "Am.", "Chem.", "Soc., 119:2056-2057 (1997); Morales et al., J.", "Am.", "Chem.", "Soc., 121:2323-2324 (1999); Guckian et al., J.", "Am.", "Chem.", "Soc., 118:8182-8183 (1996); Morales et al., J.", "Am.", "Chem.", "Soc., 122(6):1001-1007 (2000); McMinn et al., J.", "Am.", "Chem.", "Soc., 121:11585-11586 (1999); Guckian et al., J. Org.", "Chem., 63:9652-9656 (1998); Moran et al., Proc.", "Natl.", "Acad.", "Sci., 94:10506-10511 (1997); Das et al., J. Chem.", "Soc., Perkin Trans., 1:197-206 (2002); Shibata et al., J. Chem.", "Soc., Perkin Trans., 1:1605-1611 (2001); Wu et al., J.", "Am.", "Chem.", "Soc., 122(32):7621-7632 (2000); O'Neill et al., J. Org.", "Chem., 67:5869-5875 (2002); Chaudhuri et al., J.", "Am.", "Chem.", "Soc., 117:10434-10442 (1995); and U.S. Pat.", "No.", "6,218,108.Transport of iRNA Agents into Cells Not wishing to be bound by any theory, the chemical similarity between cholesterol-conjugated iRNA agents and certain constituents of lipoproteins (e.g.", "cholesterol, cholesteryl esters, phospholipids) may lead to the association of iRNA agents with lipoproteins (e.g.", "LDL, HDL) in blood and/or the interaction of the iRNA agent with cellular components having an affinity for cholesterol, e.g.", "components of the cholesterol transport pathway.", "Lipoproteins as well as their constituents are taken up and processed by cells by various active and passive transport mechanisms, for example, without limitation, endocytosis of LDL-receptor bound LDL, endocytosis of oxidized or otherwise modified LDLs through interaction with Scavenger receptor A, Scavenger receptor B1-mediated uptake of HDL cholesterol in the liver, pinocytosis, or transport of cholesterol across membranes by ABC (ATP-binding cassette) transporter proteins, e.g.", "ABC-A1, ABC-G1 or ABC-G4.Hence, cholesterol-conjugated iRNA agents could enjoy facilitated uptake by cells possessing such transport mechanisms, e.g.", "cells of the liver.", "As such, the present invention provides evidence and general methods for targeting iRNA agents to cells expressing certain cell surface components, e.g.", "receptors, by conjugating a natural ligand for such component (e.g.", "cholesterol) to the iRNA agent, or by conjugating a chemical moiety (e.g.", "cholesterol) to the iRNA agent which associates with or binds to a natural ligand for the component (e.g.", "LDL, HDL).", "Other Embodiments An iRNA agent, can be produced in a cell in vivo, e.g., from exogenous DNA templates that are delivered into the cell.", "For example, the DNA templates can be inserted into vectors and used as gene therapy vectors.", "Gene therapy vectors can be delivered to a subject by, for example, intravenous injection, local administration (U.S. Pat.", "No.", "5,328,470), or by stereotactic injection (see, e.g., Chen et al.", "Proc.", "Natl.", "Acad.", "Sci.", "USA 91:3054-3057, 1994).", "The pharmaceutical preparation of the gene therapy vector can include the gene therapy vector in an acceptable diluent, or can comprise a slow release matrix in which the gene delivery vehicle is imbedded.", "The DNA templates, for example, can include two transcription units, one that produces a transcript that includes the top strand of an iRNA agent and one that produces a transcript that includes the bottom strand of an iRNA agent.", "When the templates are transcribed, the iRNA agent is produced, and processed into siRNA agent fragments that mediate gene silencing.", "Formulation The present invention also includes pharmaceutical compositions and formulations which include the dsRNA compounds of the invention.", "The pharmaceutical compositions of the present invention may be administered in a number of ways depending upon whether local or systemic treatment is desired and upon the area to be treated.", "Administration may be topical, pulmonary, e.g., by inhalation or insufflation of powders or aerosols, including by nebulizer; intratracheal, intranasal, epidermal and transdermal, oral or parenteral.", "Parenteral administration includes intravenous, intraarterial, subcutaneous, intraperitoneal or intramuscular injection or infusion; or intracranial, e.g., intrathecal or intraventricular, administration.", "Pharmaceutical compositions and formulations for topical administration may include transdermal patches, ointments, lotions, creams, gels, drops, suppositories, sprays, liquids and powders.", "Conventional pharmaceutical carriers, aqueous, powder or oily bases, thickeners and the like may be necessary or desirable.", "Coated condoms, gloves and the like may also be useful.", "Preferred topical formulations include those in which the dsRNAs of the invention are in admixture with a topical delivery agent such as lipids, liposomes, fatty acids, fatty acid esters, steroids, chelating agents and surfactants.", "Preferred lipids and liposomes include neutral (e.g.", "dioleoylphosphatidyl ethanolamine=DOPE, dimyristoylphosphatidyl choline=DMPC, distearolyphosphatidyl choline) negative (e.g.", "dimyristoylphosphatidyl glycerol=DMPG) and cationic (e.g.", "dioleoyltetramethylaminopropyl=DOTAP and dioleoylphosphatidyl ethanolamine=DOTMA), e.g.", "(+/−)-N-(3-aminopropyl)-N,N-dimethyl-2,3-bis(dodecyloxy)-1-propanaminium bromide=GAP-DLRIE).", "DsRNAs of the invention may be encapsulated within liposomes or may form complexes thereto, in particular to cationic liposomes.", "Alternatively, dsRNAs may be complexed to lipids, in particular to cationic lipids.", "Preferred fatty acids and esters include but are not limited arachidonic acid, oleic acid, eicosanoic acid, lauric acid, caprylic acid, capric acid, myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein, dilaurin, glyceryl 1-monocaprate, 1-dodecylazacycloheptan-2-one, an acylcarnitine, an acylcholine, or a C1-10 alkyl ester (e.g.", "isopropylmyristate IPM), monoglyceride, diglyceride or pharmaceutically acceptable salt thereof.", "Topical formulations are described in detail in U.S. patent application Ser.", "No.", "09/315,298 filed on May 20, 1999 which is incorporated herein by reference in its entirety.", "Compositions and formulations for oral administration include powders or granules, microparticulates, nanoparticulates, suspensions or solutions in water or non-aqueous media, capsules, gel capsules, sachets, tablets or minitablets.", "Thickeners, flavoring agents, diluents, emulsifiers, dispersing aids or binders may be desirable.", "Preferred oral formulations are those in which dsRNAs of the invention are administered in conjunction with one or more penetration enhancers, surfactants, and chelators.", "Preferred surfactants include fatty acids and/or esters or salts thereof, bile acids and/or salts thereof.", "Preferred bile acids/salts include chenodeoxycholic acid (CDCA) and ursodeoxychenodeoxycholic acid (UDCA), cholic acid, dehydrocholic acid, deoxycholic acid, glucholic acid, glycholic acid, glycodeoxycholic acid, taurocholic acid, taurodeoxycholic acid, sodium tauro-24,25-dihydro-fusidate and sodium glycodihydrofusidate.", "Preferred fatty acids include arachidonic acid, undecanoic acid, oleic acid, lauric acid, caprylic acid, capric acid, myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein, dilaurin, glyceryl 1-monocaprate, 1-dodecylazacycloheptan-2-one, an acylcarnitine, an acylcholine, or a monoglyceride, a diglyceride or a pharmaceutically acceptable salt thereof (e.g.", "sodium).", "Also preferred are combinations of penetration enhancers, for example, fatty acids/salts in combination with bile acids/salts.", "A particularly preferred combination is the sodium salt of lauric acid, capric acid and UDCA.", "Further penetration enhancers include polyoxyethylene-9-lauryl ether, polyoxyethylene-20-cetyl ether.", "DsRNAs of the invention may be delivered orally, in granular form including sprayed dried particles, or complexed to form micro or nanoparticles.", "DsRNA complexing agents include poly-amino acids; polyimines; polyacrylates; polyalkylacrylates, polyoxethanes, polyalkylcyanoacrylates; cationized gelatins, albumins, starches, acrylates, polyethyleneglycols (PEG) and starches; polyalkylcyanoacrylates; DEAE-derivatized polyimines, pollulans, celluloses and starches.", "Particularly preferred complexing agents include chitosan, N-trimethylchitosan, poly-L-lysine, polyhistidine, polyornithine, polyspermines, protamine, polyvinylpyridine, polythiodiethylaminomethylethylene P(TDAE), poly amino styrene (e.g.", "p-amino), poly(methylcyanoacrylate), poly(ethylcyanoacrylate), poly(butylcyanoacrylate), poly(isobutylcyanoacrylate), poly(isohexylcynaoacrylate), DEAE-methacrylate, DEAE-hexylacrylate, DEAE-acrylamide, DEAE-albumin and DEAE-dextran, polymethylacrylate, polyhexylacrylate, poly(D,L-lactic acid), poly(DL-lactic-co-glycolic acid (PLGA), alginate, and polyethyleneglycol (PEG).", "Oral formulations for dsRNAs and their preparation are described in detail in U.S. application.", "Ser.", "No.", "08/886,829 (filed Jul.", "1, 1997), Ser.", "No.", "09/108,673 (filed Jul.", "1, 1998), Ser.", "No.", "09/256,515 (filed Feb. 23, 1999), Ser.", "No.", "09/082,624 (filed May 21, 1998) and Ser.", "No.", "09/315,298 (filed May 20, 1999), each of which is incorporated herein by reference in their entirety.", "Compositions and formulations for parenteral, intrathecal or intraventricular administration may include sterile aqueous solutions which may also contain buffers, diluents and other suitable additives such as, but not limited to, penetration enhancers, carrier compounds and other pharmaceutically acceptable carriers or excipients.", "Pharmaceutical compositions of the present invention include, but are not limited to, solutions, emulsions, and liposome-containing formulations.", "These compositions may be generated from a variety of components that include, but are not limited to, preformed liquids, self-emulsifying solids and self-emulsifying semisolids.", "The pharmaceutical formulations of the present invention, which may conveniently be presented in unit dosage form, may be prepared according to conventional techniques well known in the pharmaceutical industry.", "Such techniques include the step of bringing into association the active ingredients with the pharmaceutical carrier(s) or excipient(s).", "In general, the formulations are prepared by uniformly and intimately bringing into association the active ingredients with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product.", "The compositions of the present invention may be formulated into any of many possible dosage forms such as, but not limited to, tablets, capsules, gel capsules, liquid syrups, soft gels, suppositories, and enemas.", "The compositions of the present invention may also be formulated as suspensions in aqueous, non-aqueous or mixed media.", "Aqueous suspensions may further contain substances which increase the viscosity of the suspension including, for example, sodium carboxymethylcellulose, sorbitol and/or dextran.", "The suspension may also contain stabilizers.", "In one embodiment of the present invention the pharmaceutical compositions may be formulated and used as foams.", "Pharmaceutical foams include formulations such as, but not limited to, emulsions, microemulsions, creams, jellies and liposomes.", "While basically similar in nature these formulations vary in the components and the consistency of the final product.", "The preparation of such compositions and formulations is generally known to those skilled in the pharmaceutical and formulation arts and may be applied to the formulation of the compositions of the present invention.", "Emulsions The compositions of the present invention may be prepared and formulated as emulsions.", "Emulsions are typically heterogenous systems of one liquid dispersed in another in the form of droplets usually exceeding 0.1 μm in diameter (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199; Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., Volume 1, p. 245; Block in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 2, p. 335; Higuchi et al., in Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa., 1985, p. 301).", "Emulsions are often biphasic systems comprising two immiscible liquid phases intimately mixed and dispersed with each other.", "In general, emulsions may be of either the water-in-oil (w/o) or the oil-in-water (o/w) variety.", "When an aqueous phase is finely divided into and dispersed as minute droplets into a bulk oily phase, the resulting composition is called a water-in-oil (w/o) emulsion.", "Alternatively, when an oily phase is finely divided into and dispersed as minute droplets into a bulk aqueous phase, the resulting composition is called an oil-in-water (o/w) emulsion.", "Emulsions may contain additional components in addition to the dispersed phases, and the active drug which may be present as a solution in either the aqueous phase, oily phase or itself as a separate phase.", "Pharmaceutical excipients such as emulsifiers, stabilizers, dyes, and anti-oxidants may also be present in emulsions as needed.", "Pharmaceutical emulsions may also be multiple emulsions that are comprised of more than two phases such as, for example, in the case of oil-in-water-in-oil (o/w/o) and water-in-oil-in-water (w/o/w) emulsions.", "Such complex formulations often provide certain advantages that simple binary emulsions do not.", "Multiple emulsions in which individual oil droplets of an o/w emulsion enclose small water droplets constitute a w/o/w emulsion.", "Likewise a system of oil droplets enclosed in globules of water stabilized in an oily continuous phase provides an o/w/o emulsion.", "Emulsions are characterized by little or no thermodynamic stability.", "Often, the dispersed or discontinuous phase of the emulsion is well dispersed into the external or continuous phase and maintained in this form through the means of emulsifiers or the viscosity of the formulation.", "Either of the phases of the emulsion may be a semisolid or a solid, as is the case of emulsion-style ointment bases and creams.", "Other means of stabilizing emulsions entail the use of emulsifiers that may be incorporated into either phase of the emulsion.", "Emulsifiers may broadly be classified into four categories: synthetic surfactants, naturally occurring emulsifiers, absorption bases, and finely dispersed solids (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199).", "Synthetic surfactants, also known as surface active agents, have found wide applicability in the formulation of emulsions and have been reviewed in the literature (Rieger, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 285; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), Marcel Dekker, Inc., New York, N.Y., 1988, volume 1, p. 199).", "Surfactants are typically amphiphilic and comprise a hydrophilic and a hydrophobic portion.", "The ratio of the hydrophilic to the hydrophobic nature of the surfactant has been termed the hydrophile/lipophile balance (HLB) and is a valuable tool in categorizing and selecting surfactants in the preparation of formulations.", "Surfactants may be classified into different classes based on the nature of the hydrophilic group: nonionic, anionic, cationic and amphoteric (Rieger, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 285).", "Naturally occurring emulsifiers used in emulsion formulations include lanolin, beeswax, phosphatides, lecithin and acacia.", "Absorption bases possess hydrophilic properties such that they can soak up water to form w/o emulsions yet retain their semisolid consistencies, such as anhydrous lanolin and hydrophilic petrolatum.", "Finely divided solids have also been used as good emulsifiers especially in combination with surfactants and in viscous preparations.", "These include polar inorganic solids, such as heavy metal hydroxides, nonswelling clays such as bentonite, attapulgite, hectorite, kaolin, montmorillonite, colloidal aluminum silicate and colloidal magnesium aluminum silicate, pigments and nonpolar solids such as carbon or glyceryl tristearate.", "A large variety of non-emulsifying materials are also included in emulsion formulations and contribute to the properties of emulsions.", "These include fats, oils, waxes, fatty acids, fatty alcohols, fatty esters, humectants, hydrophilic colloids, preservatives and antioxidants (Block, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 335; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199).", "Hydrophilic colloids or hydrocolloids include naturally occurring gums and synthetic polymers such as polysaccharides (for example, acacia, agar, alginic acid, carrageenan, guar gum, karaya gum, and tragacanth), cellulose derivatives (for example, carboxymethylcellulose and carboxypropylcellulose), and synthetic polymers (for example, carbomers, cellulose ethers, and carboxyvinyl polymers).", "These disperse or swell in water to form colloidal solutions that stabilize emulsions by forming strong interfacial films around the dispersed-phase droplets and by increasing the viscosity of the external phase.", "Since emulsions often contain a number of ingredients such as carbohydrates, proteins, sterols and phosphatides that may readily support the growth of microbes, these formulations often incorporate preservatives.", "Commonly used preservatives included in emulsion formulations include methyl paraben, propyl paraben, quaternary ammonium salts, benzalkonium chloride, esters of p-hydroxybenzoic acid, and boric acid.", "Antioxidants are also commonly added to emulsion formulations to prevent deterioration of the formulation.", "Antioxidants used may be free radical scavengers such as tocopherols, alkyl gallates, butylated hydroxyanisole, butylated hydroxytoluene, or reducing agents such as ascorbic acid and sodium metabisulfite, and antioxidant synergists such as citric acid, tartaric acid, and lecithin.", "The application of emulsion formulations via dermatological, oral and parenteral routes and methods for their manufacture have been reviewed in the literature (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199).", "Emulsion formulations for oral delivery have been very widely used because of ease of formulation, as well as efficacy from an absorption and bioavailability standpoint (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199).", "Mineral-oil base laxatives, oil-soluble vitamins and high fat nutritive preparations are among the materials that have commonly been administered orally as o/w emulsions.", "In one embodiment of the present invention, the compositions of dsRNAs and nucleic acids are formulated as microemulsions.", "A microemulsion may be defined as a system of water, oil and amphiphile which is a single optically isotropic and thermodynamically stable liquid solution (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245).", "Typically microemulsions are systems that are prepared by first dispersing an oil in an aqueous surfactant solution and then adding a sufficient amount of a fourth component, generally an intermediate chain-length alcohol to form a transparent system.", "Therefore, microemulsions have also been described as thermodynamically stable, isotropically clear dispersions of two immiscible liquids that are stabilized by interfacial films of surface-active molecules (Leung and Shah, in: Controlled Release of Drugs: Polymers and Aggregate Systems, Rosoff, M., Ed., 1989, VCH Publishers, New York, pages 185-215).", "Microemulsions commonly are prepared via a combination of three to five components that include oil, water, surfactant, cosurfactant and electrolyte.", "Whether the microemulsion is of the water-in-oil (w/o) or an oil-in-water (o/w) type is dependent on the properties of the oil and surfactant used and on the structure and geometric packing of the polar heads and hydrocarbon tails of the surfactant molecules (Schott, in Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa., 1985, p. 271).", "The phenomenological approach utilizing phase diagrams has been extensively studied and has yielded a comprehensive knowledge, to one skilled in the art, of how to formulate microemulsions (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245; Block, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 335).", "Compared to conventional emulsions, microemulsions offer the advantage of solubilizing water-insoluble drugs in a formulation of thermodynamically stable droplets that are formed spontaneously.", "Surfactants used in the preparation of microemulsions include, but are not limited to, ionic surfactants, non-ionic surfactants, Brij 96, polyoxyethylene oleyl ethers, polyglycerol fatty acid esters, tetraglycerol monolaurate (ML310), tetraglycerol monooleate (MO310), hexaglycerol monooleate (PO310), hexaglycerol pentaoleate (PO500), decaglycerol monocaprate (MCA750), decaglycerol monooleate (MO750), decaglycerol sequioleate (SO750), decaglycerol decaoleate (DAO750), alone or in combination with cosurfactants.", "The cosurfactant, usually a short-chain alcohol such as ethanol, 1-propanol, and 1-butanol, serves to increase the interfacial fluidity by penetrating into the surfactant film and consequently creating a disordered film because of the void space generated among surfactant molecules.", "Microemulsions may, however, be prepared without the use of cosurfactants and alcohol-free self-emulsifying microemulsion systems are known in the art.", "The aqueous phase may typically be, but is not limited to, water, an aqueous solution of the drug, glycerol, PEG300, PEG400, polyglycerols, propylene glycols, and derivatives of ethylene glycol.", "The oil phase may include, but is not limited to, materials such as Captex 300, Captex 355, Capmul MCM, fatty acid esters, medium chain (C8-C12) mono, di, and tri-glycerides, polyoxyethylated glyceryl fatty acid esters, fatty alcohols, polyglycolized glycerides, saturated polyglycolized C8-C10 glycerides, vegetable oils and silicone oil.", "Microemulsions are particularly of interest from the standpoint of drug solubilization and the enhanced absorption of drugs.", "Lipid based microemulsions (both o/w and w/o) have been proposed to enhance the oral bioavailability of drugs, including peptides (Constantinides et al., Pharmaceutical Research, 1994, 11, 1385-1390; Ritschel, Meth.", "Find.", "Exp.", "Clin.", "Pharmacol., 1993, 13, 205).", "Microemulsions afford advantages of improved drug solubilization, protection of drug from enzymatic hydrolysis, possible enhancement of drug absorption due to surfactant-induced alterations in membrane fluidity and permeability, ease of preparation, ease of oral administration over solid dosage forms, improved clinical potency, and decreased toxicity (Constantinides et al., Pharmaceutical Research, 1994, 11, 1385; Ho et al., J. Pharm.", "Sci., 1996, 85, 138-143).", "Often microemulsions may form spontaneously when their components are brought together at ambient temperature.", "This may be particularly advantageous when formulating thermolabile drugs, peptides or dsRNAs.", "Microemulsions have also been effective in the transdermal delivery of active components in both cosmetic and pharmaceutical applications.", "It is expected that the microemulsion compositions and formulations of the present invention will facilitate the increased systemic absorption of dsRNAs and nucleic acids from the gastrointestinal tract, as well as improve the local cellular uptake of dsRNAs and nucleic acids within the gastrointestinal tract, vagina, buccal cavity and other areas of administration.", "Microemulsions of the present invention may also contain additional components and additives such as sorbitan monostearate (Grill 3), Labrasol, and penetration enhancers to improve the properties of the formulation and to enhance the absorption of the dsRNAs and nucleic acids of the present invention.", "Penetration enhancers used in the microemulsions of the present invention may be classified as belonging to one of five broad categories-surfactants, fatty acids, bile salts, chelating agents, and non-chelating non-surfactants (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92).", "Each of these classes has been discussed above.", "Liposomes There are many organized surfactant structures besides microemulsions that have been studied and used for the formulation of drugs.", "These include monolayers, micelles, bilayers and vesicles.", "Vesicles, such as liposomes, have attracted great interest because of their specificity and the duration of action they offer from the standpoint of drug delivery.", "As used in the present invention, the term “liposome” means a vesicle composed of amphiphilic lipids arranged in a spherical bilayer or bilayers.", "Liposomes are unilamellar or multilamellar vesicles which have a membrane formed from a lipophilic material and an aqueous interior.", "The aqueous portion contains the composition to be delivered.", "Cationic liposomes possess the advantage of being able to fuse to the cell wall.", "Non-cationic liposomes, although not able to fuse as efficiently with the cell membrane, are taken up by macrophages in vivo.", "In order to cross intact mammalian skin, lipid vesicles must pass through a series of fine pores, each with a diameter less than 50 nm, under the influence of a suitable transdermal gradient.", "Therefore, it is desirable to use a liposome which is highly deformable and able to pass through such fine pores.", "Further advantages of liposomes include; liposomes obtained from natural phospholipids are biocompatible and biodegradable; liposomes can incorporate a wide range of water and lipid soluble drugs; liposomes can protect encapsulated drugs in their internal compartments from metabolism and degradation (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.", "), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245).", "Important considerations in the preparation of liposome formulations are the lipid surface charge, vesicle size and the aqueous volume of the liposomes.", "Liposomes are useful for the transfer and delivery of active ingredients to the site of action.", "Because the liposomal membrane is structurally similar to biological membranes, when liposomes are applied to a tissue, the liposomes start to merge with the cellular membranes and as the merging of the liposome and cell progresses, the liposomal contents are emptied into the cell where the active agent may act.", "Liposomal formulations have been the focus of extensive investigation as the mode of delivery for many drugs.", "There is growing evidence that for topical administration, liposomes present several advantages over other formulations.", "Such advantages include reduced side-effects related to high systemic absorption of the administered drug, increased accumulation of the administered drug at the desired target, and the ability to administer a wide variety of drugs, both hydrophilic and hydrophobic, into the skin.", "Several reports have detailed the ability of liposomes to deliver agents including high-molecular weight DNA into the skin.", "Compounds including analgesics, antibodies, hormones and high-molecular weight DNAs have been administered to the skin.", "The majority of applications resulted in the targeting of the upper epidermis Liposomes fall into two broad classes.", "Cationic liposomes are positively charged liposomes which interact with the negatively charged DNA molecules to form a stable complex.", "The positively charged DNA/liposome complex binds to the negatively charged cell surface and is internalized in an endosome.", "Due to the acidic pH within the endosome, the liposomes are ruptured, releasing their contents into the cell cytoplasm (Wang et al., Biochem.", "Biophys.", "Res.", "Commun., 1987, 147, 980-985).", "Liposomes which are pH-sensitive or negatively-charged, entrap DNA rather than complex with it.", "Since both the DNA and the lipid are similarly charged, repulsion rather than complex formation occurs.", "Nevertheless, some DNA is entrapped within the aqueous interior of these liposomes.", "pH-sensitive liposomes have been used to deliver DNA encoding the thymidine kinase gene to cell monolayers in culture.", "Expression of the exogenous gene was detected in the target cells (Zhou et al., Journal of Controlled Release, 1992, 19, 269-274).", "One major type of liposomal composition includes phospholipids other than naturally derived phosphatidylcholine.", "Neutral liposome compositions, for example, can be formed from dimyristoyl phosphatidylcholine (DMPC) or dipalmitoyl phosphatidylcholine (DPPC).", "Anionic liposome compositions generally are formed from dimyristoyl phosphatidylglycerol, while anionic fusogenic liposomes are formed primarily from dioleoyl phosphatidyl-ethanolamine (DOPE).", "Another type of liposomal composition is formed from phosphatidylcholine (PC) such as, for example, soybean PC, and egg PC.", "Another type is formed from mixtures of phospholipid and/or phosphatidylcholine and/or cholesterol.", "Several studies have assessed the topical delivery of liposomal drug formulations to the skin.", "Application of liposomes containing interferon to guinea pig skin resulted in a reduction of skin herpes sores while delivery of interferon via other means (e.g.", "as a solution or as an emulsion) were ineffective (Weiner et al., Journal of Drug Targeting, 1992, 2, 405-410).", "Further, an additional study tested the efficacy of interferon administered as part of a liposomal formulation to the administration of interferon using an aqueous system, and concluded that the liposomal formulation was superior to aqueous administration (du Plessis et al., Antiviral Research, 1992, 18, 259-265).", "Non-ionic liposomal systems have also been examined to determine their utility in the delivery of drugs to the skin, in particular systems comprising non-ionic surfactant and cholesterol.", "Non-ionic liposomal formulations comprising Novasome™ I (glyceryl dilaurate/cholesterol/polyoxyethylene-10-stearyl ether) and Novasome™ II (glyceryl distearate/cholesterol/polyoxyethylene-10-stearyl ether) were used to deliver cyclosporin-A into the dermis of mouse skin.", "Results indicated that such non-ionic liposomal systems were effective in facilitating the deposition of cyclosporin-A into different layers of the skin (Hu et al.", "S.T.P.Pharma.", "Sci., 1994, 4, 6, 466).", "Liposomes also include “sterically stabilized” liposomes, a term which, as used herein, refers to liposomes comprising one or more specialized lipids that, when incorporated into liposomes, result in enhanced circulation lifetimes relative to liposomes lacking such specialized lipids.", "Examples of sterically stabilized liposomes are those in which part of the vesicle-forming lipid portion of the liposome (A) comprises one or more glycolipids, such as monosialoganglioside Gm1, or (B) is derivatized with one or more hydrophilic polymers, such as a polyethylene glycol (PEG) moiety.", "While not wishing to be bound by any particular theory, it is thought in the art that, at least for sterically stabilized liposomes containing gangliosides, sphingomyelin, or PEG-derivatized lipids, the enhanced circulation half-life of these sterically stabilized liposomes derives from a reduced uptake into cells of the reticuloendothelial system (RES) (Allen et al., FEBS Letters, 1987, 223, 42; Wu et al., Cancer Research, 1993, 53, 3765).", "Various liposomes comprising one or more glycolipids are known in the art.", "Papahadjopoulos et al.", "(Ann.", "N.Y. Acad.", "Sci., 1987, 507, 64) reported the ability of monosialoganglioside Gm1, galactocerebroside sulfate and phosphatidylinositol to improve blood half-lives of liposomes.", "These findings were expounded upon by Gabizon et al.", "(Proc.", "Natl.", "Acad.", "Sci.", "U.S.A., 1988, 85, 6949).", "U.S. Pat.", "No.", "4,837,028 and WO 88/04924, both to Allen et al., disclose liposomes comprising (1) sphingomyelin and (2) the ganglioside Gm1 or a galactocerebroside sulfate ester.", "U.S. Pat.", "No.", "5,543,152 (Webb et al.)", "discloses liposomes comprising sphingomyelin.", "Liposomes comprising 1,2-sn-dimyristoylphosphat-idylcholine are disclosed in WO 97/13499 (Lim et al).", "Many liposomes comprising lipids derivatized with one or more hydrophilic polymers, and methods of preparation thereof, are known in the art.", "Sunamoto et al.", "(Bull.", "Chem.", "Soc.", "Jpn., 1980, 53, 2778) described liposomes comprising a nonionic detergent, 2C1215G, that contains a PEG moiety.", "Illum et al.", "(FEBS Lett., 1984, 167, 79) noted that hydrophilic coating of polystyrene particles with polymeric glycols results in significantly enhanced blood half-lives.", "Synthetic phospholipids modified by the attachment of carboxylic groups of polyalkylene glycols (e.g., PEG) are described by Sears (U.S. Pat.", "Nos.", "4,426,330 and 4,534,899).", "Klibanov et al.", "(FEBS Lett., 1990, 268, 235) described experiments demonstrating that liposomes comprising phosphatidylethanolamine (PE) derivatized with PEG or PEG stearate have significant increases in blood circulation half-lives.", "Blume et al.", "(Biochimica et Biophysica Acta, 1990, 1029, 91) extended such observations to other PEG-derivatized phospholipids, e.g., DSPE-PEG, formed from the combination of distearoylphosphatidylethanolamine (DSPE) and PEG.", "Liposomes having covalently bound PEG moieties on their external surface are described in European Patent No.", "EP 0 445 131 B1 and WO 90/04384 to Fisher.", "Liposome compositions containing 1-20 mole percent of PE derivatized with PEG, and methods of use thereof, are described by Woodle et al.", "(U.S. Pat.", "Nos.", "5,013,556 and 5,356,633) and Martin et al.", "(U.S. Pat.", "No.", "5,213,804 and European Patent No.", "EP 0 496 813 B1).", "Liposomes comprising a number of other lipid-polymer conjugates are disclosed in WO 91/05545 and U.S. Pat.", "No.", "5,225,212 (both to Martin et al.)", "and in WO 94/20073 (Zalipsky et al.)", "Liposomes comprising PEG-modified ceramide lipids are described in WO 96/10391 (Choi et al).", "U.S. Pat.", "No.", "5,540,935 (Miyazaki et al.)", "and U.S. Pat.", "No.", "5,556,948 (Tagawa et al.)", "describe PEG-containing liposomes that can be further derivatized with functional moieties on their surfaces.", "A limited number of liposomes comprising nucleic acids are known in the art.", "WO 96/40062 to Thierry et al.", "discloses methods for encapsulating high molecular weight nucleic acids in liposomes.", "U.S. Pat.", "No.", "5,264,221 to Tagawa et al.", "discloses protein-bonded liposomes and asserts that the contents of such liposomes may include dsRNA.", "U.S. Pat.", "No.", "5,665,710 to Rahman et al.", "describes certain methods of encapsulating oligodeoxynucleotides in liposomes.", "WO 97/04787 to Love et al.", "discloses liposomes comprising dsRNAs targeted to the raf gene.", "Transfersomes are yet another type of liposomes, and are highly deformable lipid aggregates which are attractive candidates for drug delivery vehicles.", "Transfersomes may be described as lipid droplets which are so highly deformable that they are easily able to penetrate through pores which are smaller than the droplet.", "Transfersomes are adaptable to the environment in which they are used, e.g.", "they are self-optimizing (adaptive to the shape of pores in the skin), self-repairing, frequently reach their targets without fragmenting, and often self-loading.", "To make transfersomes it is possible to add surface edge-activators, usually surfactants, to a standard liposomal composition.", "Transfersomes have been used to deliver serum albumin to the skin.", "The transfersome-mediated delivery of serum albumin has been shown to be as effective as subcutaneous injection of a solution containing serum albumin.", "Surfactants find wide application in formulations such as emulsions (including microemulsions) and liposomes.", "The most common way of classifying and ranking the properties of the many different types of surfactants, both natural and synthetic, is by the use of the hydrophile/lipophile balance (HLB).", "The nature of the hydrophilic group (also known as the “head”) provides the most useful means for categorizing the different surfactants used in formulations (Rieger, in Pharmaceutical Dosage Forms, Marcel Dekker, Inc., New York, N.Y., 1988, p. 285).", "If the surfactant molecule is not ionized, it is classified as a nonionic surfactant.", "Nonionic surfactants find wide application in pharmaceutical and cosmetic products and are usable over a wide range of pH values.", "In general their HLB values range from 2 to about 18 depending on their structure.", "Nonionic surfactants include nonionic esters such as ethylene glycol esters, propylene glycol esters, glyceryl esters, polyglyceryl esters, sorbitan esters, sucrose esters, and ethoxylated esters.", "Nonionic alkanolamides and ethers such as fatty alcohol ethoxylates, propoxylated alcohols, and ethoxylated/propoxylated block polymers are also included in this class.", "The polyoxyethylene surfactants are the most popular members of the nonionic surfactant class.", "If the surfactant molecule carries a negative charge when it is dissolved or dispersed in water, the surfactant is classified as anionic.", "Anionic surfactants include carboxylates such as soaps, acyl lactylates, acyl amides of amino acids, esters of sulfuric acid such as alkyl sulfates and ethoxylated alkyl sulfates, sulfonates such as alkyl benzene sulfonates, acyl isethionates, acyl taurates and sulfosuccinates, and phosphates.", "The most important members of the anionic surfactant class are the alkyl sulfates and the soaps.", "If the surfactant molecule carries a positive charge when it is dissolved or dispersed in water, the surfactant is classified as cationic.", "Cationic surfactants include quaternary ammonium salts and ethoxylated amines.", "The quaternary ammonium salts are the most used members of this class.", "If the surfactant molecule has the ability to carry either a positive or negative charge, the surfactant is classified as amphoteric.", "Amphoteric surfactants include acrylic acid derivatives, substituted alkylamides, N-alkylbetaines and phosphatides.", "The use of surfactants in drug products, formulations and in emulsions has been reviewed (Rieger, in Pharmaceutical Dosage Forms, Marcel Dekker, Inc., New York, N.Y., 1988, p. 285).", "Penetration Enhancers In one embodiment, the present invention employs various penetration enhancers to effect the efficient delivery of nucleic acids, particularly dsRNAs, to the skin of animals.", "Most drugs are present in solution in both ionized and nonionized forms.", "However, usually only lipid soluble or lipophilic drugs readily cross cell membranes.", "It has been discovered that even non-lipophilic drugs may cross cell membranes if the membrane to be crossed is treated with a penetration enhancer.", "In addition to aiding the diffusion of non-lipophilic drugs across cell membranes, penetration enhancers also enhance the permeability of lipophilic drugs.", "Penetration enhancers may be classified as belonging to one of five broad categories, i.e., surfactants, fatty acids, bile salts, chelating agents, and non-chelating non-surfactants (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92).", "Each of the above mentioned classes of penetration enhancers are described below in greater detail.", "Surfactants: In connection with the present invention, surfactants (or “surface-active agents”) are chemical entities which, when dissolved in an aqueous solution, reduce the surface tension of the solution or the interfacial tension between the aqueous solution and another liquid, with the result that absorption of dsRNAs through the mucosa is enhanced.", "In addition to bile salts and fatty acids, these penetration enhancers include, for example, sodium lauryl sulfate, polyoxyethylene-9-lauryl ether and polyoxyethylene-20-cetyl ether) (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92); and perfluorochemical emulsions, such as FC-43 (Takahashi et al., J. Pharm.", "Pharmacol., 1988, 40, 252).", "Fatty acids: Various fatty acids and their derivatives which act as penetration enhancers include, for example, oleic acid, lauric acid, capric acid (n-decanoic acid), myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein (1-monooleoyl-rac-glycerol), dilaurin, caprylic acid, arachidonic acid, glycerol 1-monocaprate, 1-dodecylazacycloheptan-2-one, acylcarnitines, acylcholines, C1-C10 alkyl esters thereof (e.g., methyl, isopropyl and t-butyl), and mono- and di-glycerides thereof (i.e., oleate, laurate, caprate, myristate, palmitate, stearate, linoleate, etc.)", "(Lee et al., Critical Reviews in Therapeutic Drug Carryier Systems, 1991, p. 92; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; El Hariri et al., J. Pharm.", "Pharmacol., 1992, 44, 651-654).", "Bile Salts: The physiological role of bile includes the facilitation of dispersion and absorption of lipids and fat-soluble vitamins (Brunton, Chapter 38 in: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th Ed., Hardman et al.", "Eds., McGraw-Hill, New York, 1996, pp.", "934-935).", "Various natural bile salts, and their synthetic derivatives, act as penetration enhancers.", "Thus the term “bile salts” includes any of the naturally occurring components of bile as well as any of their synthetic derivatives.", "The bile salts of the invention include, for example, cholic acid (or its pharmaceutically acceptable sodium salt, sodium cholate), dehydrocholic acid (sodium dehydrocholate), deoxycholic acid (sodium deoxycholate), glucholic acid (sodium glucholate), glycholic acid (sodium glycocholate), glycodeoxycholic acid (sodium glycodeoxycholate), taurocholic acid (sodium taurocholate), taurodeoxycholic acid (sodium taurodeoxycholate), chenodeoxycholic acid (sodium chenodeoxycholate), ursodeoxycholic acid (UDCA), sodium tauro-24,25-dihydro-fusidate (STDHF), sodium glycodihydrofusidate and polyoxyethylene-9-lauryl ether (POE) (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92; Swinyard, Chapter 39 In: Remington's Pharmaceutical Sciences, 18th Ed., Gennaro, ed., Mack Publishing Co., Easton, Pa., 1990, pages 782-783; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; Yamamoto et al., J. Pharm.", "Exp.", "Ther., 1992, 263, 25; Yamashita et al., J. Pharm.", "Sci., 1990, 79, 579-583).", "Chelating Agents: Chelating agents, as used in connection with the present invention, can be defined as compounds that remove metallic ions from solution by forming complexes therewith, with the result that absorption of dsRNAs through the mucosa is enhanced.", "With regards to their use as penetration enhancers in the present invention, chelating agents have the added advantage of also serving as DNase inhibitors, as most characterized DNA nucleases require a divalent metal ion for catalysis and are thus inhibited by chelating agents (Jarrett, J.", "Chromatogr., 1993, 618, 315-339).", "Chelating agents of the invention include but are not limited to disodium ethylenediaminetetraacetate (EDTA), citric acid, salicylates (e.g., sodium salicylate, 5-methoxysalicylate and homovanilate), N-acyl derivatives of collagen, laureth-9 and N-amino acyl derivatives of beta-diketones (enamines)(Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; Buur et al., J.", "Control Rel., 1990, 14, 43-51).", "Non-chelating non-surfactants: As used herein, non-chelating non-surfactant penetration enhancing compounds can be defined as compounds that demonstrate insignificant activity as chelating agents or as surfactants but that nonetheless enhance absorption of dsRNAs through the alimentary mucosa (Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33).", "This class of penetration enhancers include, for example, unsaturated cyclic ureas, 1-alkyl- and 1-alkenylazacyclo-alkanone derivatives (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92); and non-steroidal anti- to inflammatory agents such as diclofenac sodium, indomethacin and phenylbutazone (Yamashita et al., J. Pharm.", "Pharmacol., 1987, 39, 621-626).", "Agents that enhance uptake of dsRNAs at the cellular level may also be added to the pharmaceutical and other compositions of the present invention.", "For example, cationic lipids, such as lipofectin (Junichi et al, U.S. Pat.", "No.", "5,705,188), cationic glycerol derivatives, and polycationic molecules, such as polylysine (Lollo et al., PCT Application WO 97/30731) and other peptides, are also known to enhance the cellular uptake of dsRNAs.", "Other agents may be utilized to enhance the penetration of the administered nucleic acids, including glycols such as ethylene glycol and propylene glycol, pyrrols such as 2-pyrrol, azones, and terpenes such as limonene and menthone.", "Carriers Certain compositions of the present invention also incorporate carrier compounds in the formulation.", "As used herein, “carrier compound” or “carrier” can refer to a nucleic acid, or analog thereof, which is inert (i.e., does not possess biological activity per se) but is recognized as a nucleic acid by in vivo processes that reduce the bioavailability of a nucleic acid having biological activity by, for example, degrading the biologically active nucleic acid or promoting its removal from circulation.", "The coadministration of a nucleic acid and a carrier compound, typically with an excess of the latter substance, can result in a substantial reduction of the amount of nucleic acid recovered in the liver, kidney or other extracirculatory reservoirs, presumably due to competition between the carrier compound and the nucleic acid for a common receptor.", "For example, the recovery of a partially phosphorothioate dsRNA in hepatic tissue can be reduced when it is coadministered with polyinosinic acid, dextran sulfate, polycytidic acid or 4-acetamido-4′isothiocyano-stilbene-2,2′-disulfonic acid (Miyao et al., Antisense Res.", "Dev., 1995, 5, 115-121; Takakura et al., Antisense & Nucl.", "Acid Drug Dev., 1996, 6, 177-183.Excipients In contrast to a carrier compound, a “pharmaceutical carrier” or “excipient” is a pharmaceutically acceptable solvent, suspending agent or any other pharmacologically inert vehicle for delivering one or more nucleic acids to an animal.", "The excipient may be liquid or solid and is selected, with the planned manner of administration in mind, so as to provide for the desired bulk, consistency, etc., when combined with a nucleic acid and the other components of a given pharmaceutical composition.", "Typical pharmaceutical carriers include, but are not limited to, binding agents (e.g., pregelatinized maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose, etc.", "); fillers (e.g., lactose and other sugars, microcrystalline cellulose, pectin, gelatin, calcium sulfate, ethyl cellulose, polyacrylates or calcium hydrogen phosphate, etc.", "); lubricants (e.g., magnesium stearate, talc, silica, colloidal silicon dioxide, stearic acid, metallic stearates, hydrogenated vegetable oils, corn starch, polyethylene glycols, sodium benzoate, sodium acetate, etc.", "); disintegrants (e.g., starch, sodium starch glycolate, etc.", "); and wetting agents (e.g., sodium lauryl sulphate, etc).", "Pharmaceutically acceptable organic or inorganic excipient suitable for non-parenteral administration which do not deleteriously react with nucleic acids can also be used to formulate the compositions of the present invention.", "Suitable pharmaceutically acceptable carriers include, but are not limited to, water, salt solutions, alcohols, polyethylene glycols, gelatin, lactose, amylose, magnesium stearate, talc, silicic acid, viscous paraffin, hydroxymethylcellulose, polyvinylpyrrolidone and the like.", "Formulations for topical administration of nucleic acids may include sterile and non-sterile aqueous solutions, non-aqueous solutions in common solvents such as alcohols, or solutions of the nucleic acids in liquid or solid oil bases.", "The solutions may also contain buffers, diluents and other suitable additives.", "Pharmaceutically acceptable organic or inorganic excipients suitable for non-parenteral administration which do not deleteriously react with nucleic acids can be used.", "Suitable pharmaceutically acceptable excipients include, but are not limited to, water, salt solutions, alcohol, polyethylene glycols, gelatin, lactose, amylose, magnesium stearate, talc, silicic acid, viscous paraffin, hydroxymethylcellulose, polyvinylpyrrolidone and the like.", "Pharmaceutical Compositions for the Delivery to the Respiratory Tract Another aspect of the invention provides for the delivery of iRNA agents to the respiratory tract, particularly for the treatment of cystic fibrosis.", "The respiratory tract includes the upper airways, including the oropharynx and larynx, followed by the lower airways, which include the trachea followed by bifurcations into the bronchi and bronchioli.", "The upper and lower airways are called the conductive airways.", "The terminal bronchioli then divide into respiratory bronchioli which then lead to the ultimate respiratory zone, the alveoli, or deep lung.", "The epithelium of the conductive airways is the primary target of inhaled therapeutic aerosols for delivery of iRNA agents such as alpha-ENaC iRNA agents.", "Pulmonary delivery compositions can be delivered by inhalation by the patient of a dispersion so that the composition, preferably the iRNA agent, within the dispersion can reach the lung where it can, for example, be readily absorbed through the alveolar region directly into blood circulation.", "Pulmonary delivery can be effective both for systemic delivery and for localized delivery to treat diseases of the lungs.", "Pulmonary delivery can be achieved by different approaches, including the use of nebulized, aerosolized, micellular and dry powder-based formulations; administration by inhalation may be oral and/or nasal.", "Delivery can be achieved with liquid nebulizers, aerosol-based inhalers, and dry powder dispersion devices.", "Metered-dose devices are preferred.", "One of the benefits of using an atomizer or inhaler is that the potential for contamination is minimized because the devices are self contained.", "Dry powder dispersion devices, for example, deliver drugs that may be readily formulated as dry powders.", "An iRNA composition may be stably stored as lyophilized or spray-dried powders by itself or in combination with suitable powder carriers.", "The delivery of a composition for inhalation can be mediated by a dosing timing element which can include a timer, a dose counter, time measuring device, or a time indicator which when incorporated into the device enables dose tracking, compliance monitoring, and/or dose triggering to a patient during administration of the aerosol medicament.", "Examples of pharmaceutical devices for aerosol delivery include metered dose inhalers (MDIs), dry powder inhalers (DPIs), and air-jet nebulizers.", "Exemplary delivery systems by inhalation which can be readily adapted for delivery of the subject iRNA agents are described in, for example, U.S. Pat.", "Nos.", "5,756,353; 5,858,784; and PCT applications WO98/31346; WO98/10796; WO00/27359; WO01/54664; WO02/060412.Other aerosol formulations that may be used for delivering the iRNA agents are described in U.S. Pat.", "Nos.", "6,294,153; 6,344,194; 6,071,497, and PCT applications WO02/066078; WO02/053190; WO01/60420; WO00/66206.Further, methods for delivering iRNA agents can be adapted from those used in delivering other oligonucleotides (e.g., an antisense oligonucleotide) by inhalation, such as described in Templin et al., Antisense Nucleic Acid Drug Dev, 2000, 10:359-68; Sandrasagra et al., Expert Opin Biol Ther, 2001, 1:979-83; Sandrasagra et al., Antisense Nucleic Acid Drug Dev, 2002, 12:177-81.The delivery of the inventive agents may also involve the administration of so called “pro-drugs”, i.e.", "formulations or chemical modifications of a therapeutic substance that require some form of processing or transport by systems innate to the subject organism to release the therapeutic substance, preferably at the site where its action is desired; this latter embodiment may be used in conjunction with delivery of the respiratory tract, but also together with other embodiments of the present invention.", "For example, the human lungs can remove or rapidly degrade hydrolytically cleavable deposited aerosols over periods ranging from minutes to hours.", "In the upper airways, ciliated epithelia contribute to the “mucociliary excalator” by which particles are swept from the airways toward the mouth.", "Pavia, D., “Lung Mucociliary Clearance,” in Aerosols and the Lung: Clinical and Experimental Aspects, Clarke, S. W. and Pavia, D., Eds., Butterworths, London, 1984.In the deep lungs, alveolar macrophages are capable of phagocytosing particles soon after their deposition.", "Warheit et al.", "Microscopy Res.", "Tech., 26: 412-422 (1993); and Brain, J. D., “Physiology and Pathophysiology of Pulmonary Macrophages,” in The Reticuloendothelial System, S. M. Reichard and J. Filkins, Eds., Plenum, N.Y., pp.", "315-327, 1985.In preferred embodiments, particularly where systemic dosing with the iRNA agent is desired, the aerosoled iRNA agents are formulated as microparticles.", "Microparticles having a diameter of between 0.5 and ten microns can penetrate the lungs, passing through most of the natural barriers.", "A diameter of less than ten microns is required to bypass the throat; a diameter of 0.5 microns or greater is required to avoid being exhaled.", "Other Components Compositions of the present invention may additionally contain other adjunct components conventionally found in pharmaceutical compositions, at their art-established usage levels.", "Thus, for example, the compositions may contain additional, compatible, pharmaceutically-active materials such as, for example, antipruritics, astringents, local anesthetics or anti-inflammatory agents, or may contain additional materials useful in physically formulating various dosage forms of the compositions of the present invention, such as dyes, flavoring agents, preservatives, antioxidants, opacifiers, thickening agents and stabilizers.", "However, such materials, when added, should not unduly interfere with the biological activities of the components of the compositions of the present invention.", "The formulations can be sterilized and, if desired, mixed with auxiliary agents, e.g., lubricants, preservatives, stabilizers, wetting agents, emulsifiers, salts for influencing osmotic pressure, buffers, colorings, flavorings and/or aromatic substances and the like which do not deleteriously interact with the nucleic acid(s) of the formulation.", "Aqueous suspensions may contain substances which increase the viscosity of the suspension including, for example, sodium carboxymethylcellulose, sorbitol and/or dextran.", "The suspension may also contain stabilizers.", "Certain embodiments of the invention provide pharmaceutical combinations and compositions containing (a) one or more dsRNA agents and (b) one or more other therapeutic agents which function by a non-RNA interference mechanism.", "Accordingly, the invention includes a combination of an iRNA of the present invention with an anti-inflammatory, bronchodilatory, antihistamine, anti-tussive, antibiotic or DNase drug substance, said epithelial sodium channel blocker and said drug substance being in the same or different pharmaceutical composition.", "Suitable antibiotics include macrolide antibiotics, e.g., tobramycin (TOBI™).", "Suitable DNase drug substances include dornase alfa (Pulmozyme™), a highly-purified solution of recombinant human deoxyribonuclease I (rhDNase), which selectively cleaves DNA.", "Dornase alfa is used to treat cystic fibrosis.", "Other useful combinations of epithelial sodium channel blockers with anti-inflammatory drugs are those with antagonists of chemokine receptors, e.g., CCR-1, CCR-2, CCR-3, CCR-4, CCR-5, CCR-6, CCR-7, CCR-8, CCR-9 and CCR10, CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, particularly CCR-5 antagonists, such as Schering-Plough antagonists SC-351125, SCH-55700 and SCH-D; Takeda antagonists, such as N-[[4-[[[6,7-dihydro-2-(4-methyl-phenyl)-5H-benzo-cyclohepten-8-yl]carbonyl]amino]phenyl]-methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-amin-ium chloride (TAK-770); and CCR-5 antagonists described in U.S. Pat.", "No.", "6,166,037 (particularly claims 18 and 19), WO 00/66558 (particularly claim 8), WO 00/66559 (particularly claim 9), WO 04/018425 and WO 04/026873.Suitable anti-inflammatory drugs include steroids, in particular, glucocorticosteroids, such as budesonide, beclamethasone dipropionate, fluticasone propionate, ciclesonide or mometasone furoate, or steroids described in WO 02/88167, WO 02/12266, WO 02/100879, WO 02/00679 (especially those of Examples 3, 11, 14, 17, 19, 26, 34, 37, 39, 51, 60, 67, 72, 73, 90, 99 and 101), WO 03/35668, WO 03/48181, WO 03/62259, WO 03/64445, WO 03/72592, WO 04/39827 and WO 04/66920; non-steroidal glucocorticoid receptor agonists, such as those described in DE 10261874, WO 00/00531, WO 02/10143, WO 03/82280, WO 03/82787, WO 03/86294, WO 03/104195, WO 03/101932, WO 04/05229, WO 04/18429, WO 04/19935 and WO 04/26248; LTD4 antagonists, such as montelukast and zafirlukast; PDE4 inhibitors, such as cilomilast (Ariflo® GlaxoSmithKline), Roflumilast (Byk Gulden), V-11294A (Napp), BAY19-8004 (Bayer), SCH-351591 (Schering-Plough), Arofylline (Almirall Prodesfarma), PD189659/PD168787 (Parke-Davis), AWD-12-281 (Asta Medica), CDC-801 (Celgene), SelCID™ CC-10004 (Celgene), VM554/UM565 (Vernalis), T-440 (Tanabe), KW-4490 (Kyowa Hakko Kogyo), and those disclosed in WO 92/19594, WO 93/19749, WO 93/19750, WO 93/19751, WO 98/18796, WO 99/16766, WO 01/13953, WO 03/104204, WO 03/104205, WO 03/39544, WO 04/000814, WO 04/000839, WO 04/005258, WO 04/018450, WO 04/018451, WO 04/018457, WO 04/018465, WO 04/018431, WO 04/018449, WO 04/018450, WO 04/018451, WO 04/018457, WO 04/018465, WO 04/019944, WO 04/019945, WO 04/045607 and WO 04/037805; adenosine A2B receptor antagonists such as those described in WO 02/42298; and beta-2 adrenoceptor agonists, such as albuterol (salbutamol), metaproterenol, terbutaline, salmeterol fenoterol, procaterol, and especially, formoterol, carmoterol and pharmaceutically acceptable salts thereof, and compounds (in free or salt or solvate form) of formula (I) of WO 0075114, which document is incorporated herein by reference, preferably compounds of the Examples thereof, especially indacaterol and pharmaceutically acceptable salts thereof, as well as compounds (in free or salt or solvate form) of formula (I) of WO 04/16601, and also compounds of EP 1440966, JP 05025045, WO 93/18007, WO 99/64035, USP 2002/0055651, WO 01/42193, WO 01/83462, WO 02/66422, WO 02/70490, WO 02/76933, WO 03/24439, WO 03/42160, WO 03/42164, WO 03/72539, WO 03/91204, WO 03/99764, WO 04/16578, WO 04/22547, WO 04/32921, WO 04/33412, WO 04/37768, WO 04/37773, WO 04/37807, WO 04/39762, WO 04/39766, WO 04/45618, WO 04/46083, WO 04/80964, WO 04/108765 and WO 04/108676.Suitable bronchodilatory drugs include anticholinergic or antimuscarinic agents, in particular, ipratropium bromide, oxitropium bromide, tiotropium salts and CHF 4226 (Chiesi), and glycopyrrolate, but also those described in EP 424021, U.S. Pat.", "No.", "3,714,357, U.S. Pat.", "No.", "5,171,744, WO 01/04118, WO 02/00652, WO 02/51841, WO 02/53564, WO 03/00840, WO 03/33495, WO 03/53966, WO 03/87094, WO 04/018422 and WO 04/05285.Suitable dual anti-inflammatory and bronchodilatory drugs include dual beta-2 adrenoceptor agonist/muscarinic antagonists such as those disclosed in USP 2004/0167167, WO 04/74246 and WO 04/74812.Suitable antihistamine drug substances include cetirizine hydrochloride, acetaminophen, clemastine fumarate, promethazine, loratidine, desloratidine, diphenhydramine and fexofenadine hydrochloride, activastine, astemizole, azelastine, ebastine, epinastine, mizolastine and tefenadine, as well as those disclosed in JP 2004107299, WO 03/099807 and WO 04/026841.Other useful combinations of agents of the invention with anti-inflammatory drugs are those with antagonists of chemokine receptors, e.g., CCR-1, CCR-2, CCR-3, CCR-4, CCR-5, CCR-6, CCR-7, CCR-8, CCR-9 and CCR10, CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, particularly CCR-5 antagonists, such as Schering-Plough antagonists SC-351125, SCH-55700 and SCH-D; Takeda antagonists, such as N-[[4-[[[6,7-dihydro-2-(4-methylphenyl)-511-benzo-cyclohepten-8-yl]carbonyl]amino]phenyl]-methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-amin-ium chloride (TAK-770), and CCR-5 antagonists described in U.S. Pat.", "No.", "6,166,037 (particularly claims 18 and 19), WO 00/66558 (particularly claim 8), WO 00/66559 (particularly claim 9), WO 04/018425 and WO 04/026873.Other useful additional therapeutic agents may also be selected from the group consisting of cytokine binding molecules, particularly antibodies of other cytokines, in particular a combination with an anti-IL4 antibody, such as described in PCT/EP2005/00836, an anti-IgE antibody, such as Xolair®, an anti-IL31 antibody, an anti-IL31R antibody, an anti-TSLP antibody, an anti-TSLP receptor antibody, an anti-endoglin antibody, an anti-IL1b antibody or an anti-IL13 antibody, such as described in WO05/007699.Two or more combined compounds may be used together in a single formulation, separately, concomitantly or sequentially.", "Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population).", "The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD50/ED50.Compounds which exhibit high therapeutic indices are preferred.", "The data obtained from cell culture assays and animal studies can be used in formulating a range of dosage for use in humans.", "The dosage of compositions of the invention lies generally within a range of circulating concentrations that include the ED50 with little or no toxicity.", "The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized.", "For any compound used in the method of the invention, the therapeutically effective dose can be estimated initially from cell culture assays.", "A dose may be formulated in animal models to achieve a circulating plasma concentration range of the compound or, when appropriate, of the polypeptide product of a target sequence (e.g., achieving a decreased concentration of the polypeptide) that includes the IC50 (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture.", "Such information can be used to more accurately determine useful doses in humans.", "Levels in plasma may be measured, for example, by high performance liquid chromatography.", "In addition to their administration individually or as a plurality, as discussed above, the dsRNAs of the invention can be administered in combination with other known agents effective in treatment of ENaC related disorders.", "In any event, the administering physician can adjust the amount and timing of dsRNA administration on the basis of results observed using standard measures of efficacy known in the art or described herein.", "Treatment Methods and Routes of Delivery A composition that includes an iRNA agent, e.g., an iRNA agent that targets alpha-ENaC, can be delivered to a subject by a variety of routes to achieve either local delivery to the site of action or systemic delivery to the subject.", "Exemplary routes include direct local administration to the site of treatment, such as the lungs and nasal passage as well as intravenous, nasal, oral, and ocular delivery.", "The preferred means of administering the iRNA agents of the present invention is through direct administration to the lungs and nasal passage as a liquid, aerosol or nebulized solution.", "Formulations for inhalation or parenteral administration are well known in the art.", "Such formulation may include sterile aqueous solutions which may also contain buffers, diluents and other suitable additives.", "For intravenous use, the total concentration of solutes should be controlled to render the preparation isotonic.", "The active compounds disclosed herein are preferably administered to the lung(s) or nasal passage of a subject by any suitable means.", "Active compounds may be administered by administering an aerosol suspension of respirable particles comprised of the active compound or active compounds, which the subject inhales.", "The active compound can be aerosolized in a variety of forms, such as, but not limited to, dry powder inhalants, metered dose inhalants, or liquid/liquid suspensions.", "The respirable particles may be liquid or solid.", "The particles may optionally contain other therapeutic ingredients such as amiloride, benzamil or phenamil, with the selected compound included in an amount effective to inhibit the reabsorption of water from airway mucous secretions, as described in U.S. Pat.", "No.", "4,501,729.The particulate pharmaceutical composition may optionally be combined with a carrier to aid in dispersion or transport.", "A suitable carrier such as a sugar (i.e., lactose, sucrose, trehalose, mannitol) may be blended with the active compound or compounds in any suitable ratio (e.g., a 1 to 1 ratio by weight).", "Particles comprised of the active compound for practicing the present invention should include particles of respirable size, that is, particles of a size sufficiently small to pass through the mouth or nose and larynx upon inhalation and into the bronchi and alveoli of the lungs.", "In general, particles ranging from about 1 to 10 microns in size (more particularly, less than about 5 microns in size) are respirable.", "Particles of non-respirable size which are included in the aerosol tend to deposit in the throat and be swallowed, and the quantity of non-respirable particles in the aerosol is preferably minimized.", "For nasal administration, a particle size in the range of 10-500 uM is preferred to ensure retention in the nasal cavity.", "Liquid pharmaceutical compositions of active compound for producing an aerosol may be prepared by combining the active compound with a suitable vehicle, such as sterile pyrogen free water.", "The hypertonic saline solutions used to carry out the present invention are preferably sterile, pyrogen-free solutions, comprising from one to fifteen percent (by weight) of the physiologically acceptable salt, and more preferably from three to seven percent by weight of the physiologically acceptable salt.", "Aerosols of liquid particles comprising the active compound may be produced by any suitable means, such as with a pressure-driven jet nebulizer or an ultrasonic nebulizer.", "See, e.g., U.S. Pat.", "No.", "4,501,729.Nebulizers are commercially available devices which transform solutions or suspensions of the active ingredient into a therapeutic aerosol mist either by means of acceleration of compressed gas, typically air or oxygen, through a narrow venturi orifice or by means of ultrasonic agitation.", "Suitable formulations for use in nebulizers consist of the active ingredient in a liquid carrier, the active ingredient comprising up to 40% w/w of the formulation, but preferably less than 20% w/w.", "The carrier is typically water (and most preferably sterile, pyrogen-free water) or a dilute aqueous alcoholic solution, preferably made isotonic, but may be hypertonic with body fluids by the addition of, for example, sodium chloride.", "Optional additives include preservatives if the formulation is not made sterile, for example, methyl hydroxybenzoate, antioxidants, flavoring agents, volatile oils, buffering agents and surfactants.", "Aerosols of solid particles comprising the active compound may likewise be produced with any solid particulate therapeutic aerosol generator.", "Aerosol generators for administering solid particulate therapeutics to a subject produce particles which are respirable and generate a volume of aerosol containing a predetermined metered dose of a therapeutic at a rate suitable for human administration.", "One illustrative type of solid particulate aerosol generator is an insufflator.", "Suitable formulations for administration by insufflation include finely comminuted powders which may be delivered by means of an insufflator or taken into the nasal cavity in the manner of a snuff.", "In the insufflator, the powder (e.g., a metered dose thereof effective to carry out the treatments described herein) is contained in capsules or cartridges, typically made of gelatin or plastic, which are either pierced or opened in situ and the powder delivered by air drawn through the device upon inhalation or by means of a manually-operated pump.", "The powder employed in the insufflator consists either solely of the active ingredient or of a powder blend comprising the active ingredient, a suitable powder diluent, such as lactose, and an optional surfactant.", "The active ingredient typically comprises from 0.1 to 100 w/w of the formulation.", "A second type of illustrative aerosol generator comprises a metered dose inhaler.", "Metered dose inhalers are pressurized aerosol dispensers, typically containing a suspension or solution formulation of the active ingredient in a liquefied propellant.", "During use these devices discharge the formulation through a valve adapted to deliver a metered volume, typically from 10 to 200 ul, to produce a fine particle spray containing the active ingredient.", "Suitable propellants include certain chlorofluorocarbon compounds, for example, dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane and mixtures thereof.", "The formulation may additionally contain one or more co-solvents, for example, ethanol, surfactants, such as oleic acid or sorbitan trioleate, antioxidant and suitable flavoring agents.", "An iRNA agent can be incorporated into pharmaceutical compositions suitable for administration.", "For example, compositions can include one or more species of an iRNA agent and a pharmaceutically acceptable carrier.", "As used herein the language “pharmaceutically acceptable carrier” is intended to include any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like, compatible with pharmaceutical administration.", "The use of such media and agents for pharmaceutically active substances is well known in the art.", "Except insofar as any conventional media or agent is incompatible with the active compound, use thereof in the compositions is contemplated.", "Supplementary active compounds can also be incorporated into the compositions.", "Administration can be provided by the subject or by another person, e.g., a caregiver.", "A caregiver can be any entity involved with providing care to the human: for example, a hospital, hospice, doctor's office, outpatient clinic; a healthcare worker such as a doctor, nurse, or other practitioner; or a spouse or guardian, such as a parent.", "The medication can be provided in measured doses or in a dispenser which delivers a metered dose.", "The term “therapeutically effective amount” is the amount present in the composition that is needed to provide the desired level of drug in the subject to be treated to give the anticipated physiological response.", "The term “physiologically effective amount” is that amount delivered to a subject to give the desired palliative or curative effect.", "The term “pharmaceutically acceptable carrier” means that the carrier can be taken into the lungs with no significant adverse toxicological effects on the lungs.", "The term “co-administration” refers to administering to a subject two or more agents, and in particular two or more iRNA agents.", "The agents can be contained in a single pharmaceutical composition and be administered at the same time, or the agents can be contained in separate formulation and administered serially to a subject.", "So long as the two agents can be detected in the subject at the same time, the two agents are said to be co-administered.", "The types of pharmaceutical excipients that are useful as carrier include stabilizers such as human serum albumin (HSA), bulking agents such as carbohydrates, amino acids and polypeptides; pH adjusters or buffers; salts such as sodium chloride; and the like.", "These carriers may be in a crystalline or amorphous form or may be a mixture of the two.", "Bulking agents that are particularly valuable include compatible carbohydrates, polypeptides, amino acids or combinations thereof.", "Suitable carbohydrates include monosaccharides such as galactose, D-mannose, sorbose, and the like; disaccharides, such as lactose, trehalose, and the like; cyclodextrins, such as 2-hydroxypropyl-.beta.-cyclodextrin; and polysaccharides, such as raffinose, maltodextrins, dextrans, and the like; alditols, such as mannitol, xylitol, and the like.", "A preferred group of carbohydrates includes lactose, threhalose, raffinose maltodextrins, and mannitol.", "Suitable polypeptides include aspartame.", "Amino acids include alanine and glycine, with glycine being preferred.", "Suitable pH adjusters or buffers include organic salts prepared from organic acids and bases, such as sodium citrate, sodium ascorbate, and the like; sodium citrate is preferred.", "Dosage An iRNA agent can be administered at a unit dose less than about 75 mg per kg of bodyweight, or less than about 70, 60, 50, 40, 30, 20, 10, 5, 2, 1, 0.5, 0.1, 0.05, 0.01, 0.005, 0.001, or 0.0005 mg per kg of bodyweight, and less than 200 nmol of iRNA agent (e.g., about 4.4×1016 copies) per kg of bodyweight, or less than 1500, 750, 300, 150, 75, 15, 7.5, 1.5, 0.75, 0.15, 0.075, 0.015, 0.0075, 0.0015, 0.00075, 0.00015 nmol of iRNA agent per kg of bodyweight.", "The unit dose, for example, can be administered by injection (e.g., intravenous or intramuscular, intrathecally, or directly into an organ), an inhaled dose, or a topical application.", "The dosage can be an amount effective to treat or prevent a disease or disorder.", "It can be given prophylactically or as the primary or a part of a treatment protocol.", "In one embodiment, the unit dose is administered less frequently than once a day, e.g., less than every 2, 4, 8 or 30 days.", "In another embodiment, the unit dose is not administered with a frequency (e.g., not a regular frequency).", "For example, the unit dose may be administered a single time.", "Because iRNA agent mediated silencing can persist for several days after administering the iRNA agent composition, in many instances, it is possible to administer the composition with a frequency of less than once per day, or, for some instances, only once for the entire therapeutic regimen.", "In one embodiment, a subject is administered an initial dose, and one or more maintenance doses of an iRNA agent, e.g., a double-stranded iRNA agent, or siRNA agent, (e.g., a precursor, e.g., a larger iRNA agent which can be processed into an siRNA agent, or a DNA which encodes an iRNA agent, e.g., a double-stranded iRNA agent, or siRNA agent, or precursor thereof).", "The maintenance dose or doses are generally lower than the initial dose, e.g., one-half less of the initial dose.", "A maintenance regimen can include treating the subject with a dose or doses ranging from 0.01 to 75 mg/kg of body weight per day, e.g., 70, 60, 50, 40, 30, 20, 10, 5, 2, 1, 0.5, 0.1, 0.05, 0.01, 0.005, 0.001, or 0.0005 mg per kg of body weight per day.", "The maintenance doses are preferably administered no more than once every 5, 10, or 30 days.", "Further, the treatment regimen may last for a period of time which will vary depending upon the nature of the particular disease, its severity and the overall condition of the patient.", "In preferred embodiments the dosage may be delivered no more than once per day, e.g., no more than once per 24, 36, 48, or more hours, e.g., no more than once every 5 or 8 days.", "Following treatment, the patient can be monitored for changes in his condition and for alleviation of the symptoms of the disease state.", "The dosage of the compound may either be increased in the event the patient does not respond significantly to current dosage levels, or the dose may be decreased if an alleviation of the symptoms of the disease state is observed, if the disease state has been ablated, or if undesired side-effects are observed.", "The effective dose can be administered in a single dose or in two or more doses, as desired or considered appropriate under the specific circumstances.", "If desired to facilitate repeated or frequent infusions, implantation of a delivery device, e.g., a pump, semi-permanent stent (e.g., intravenous, intraperitoneal, intracisternal or intracapsular), or reservoir may be advisable.", "Following successful treatment, it may be desirable to have the patient undergo maintenance therapy to prevent the recurrence of the disease state, wherein the compound of the invention is administered in maintenance doses, ranging from 0.001 g to 100 g per kg of body weight (see U.S. Pat.", "No.", "6,107,094).", "The concentration of the iRNA agent composition is an amount sufficient to be effective in treating or preventing a disorder or to regulate a physiological condition in humans.", "The concentration or amount of iRNA agent administered will depend on the parameters determined for the agent and the method of administration, e.g.", "nasal, buccal, or pulmonary.", "For example, nasal formulations tend to require much lower concentrations of some ingredients in order to avoid irritation or burning of the nasal passages.", "It is sometimes desirable to dilute an oral formulation up to 10-100 times in order to provide a suitable nasal formulation.", "Certain factors may influence the dosage required to effectively treat a subject, including but not limited to the severity of the disease or disorder, previous treatments, the general health and/or age of the subject, and other diseases present.", "It will also be appreciated that the effective dosage of an iRNA agent such as an siRNA used for treatment may increase or decrease over the course of a particular treatment.", "Changes in dosage may result and become apparent from the results of diagnostic assays.", "For example, the subject can be monitored after administering an iRNA agent composition.", "Based on information from the monitoring, an additional amount of the iRNA agent composition can be administered.", "Dosing is dependent on severity and responsiveness of the disease condition to be treated, with the course of treatment lasting from several days to several months, or until a cure is effected or a diminution of disease state is achieved.", "Optimal dosing schedules can be calculated from measurements of drug accumulation in the body of the patient.", "Persons of ordinary skill can easily determine optimum dosages, dosing methodologies and repetition rates.", "Optimum dosages may vary depending on the relative potency of individual compounds, and can generally be estimated based on EC50s found to be effective in in vitro and in vivo animal models as described above.", "iRNA agents of the present invention as described herein may be useful in the treatment and (where appropriate) in the prevention of any one of the following diseases/disorders; Cystic fibrosis, Liddles syndrome, renal insufficiency, hypertension, electrolyte imbalances.", "In particular in some embodiments, iRNA agents of the invention may be used to treat and/or prevent adverse clinical manifestations of these diseases/disorders.", "The invention is further illustrated by the following examples, which should not be construed as further limiting.", "EXAMPLES Source of Reagents Where the source of a reagent is not specifically given herein, such reagent may be obtained from any supplier of reagents for molecular biology at a quality/purity standard for application in molecular biology.", "Example 1: Selection of Sequences In order to identify therapeutic siRNAs to downmodulate expression of the alpha subunit of the epithelial sodium channel ENaC (α-ENaC), screening sets were defined based on a bioinformatic analysis.", "The key drivers for the design of the screening set were predicted specificity of the siRNAs against the transcriptome of the relevant species.", "For the identification of alpha-ENaC siRNAs and an efficient delivery system a three pronged approach was used: Rat was selected as the test species to address silencing efficacy in vivo after intratracheal delivery, guinea pig was selected as the disease model organism to demonstrate that alpha-ENaC mRNA reduction results in a measurable functional effect.", "The therapeutic siRNA molecule has to target human alpha-ENaC as well as the alpha-ENaC sequence of at least one toxicology-relevant species, in this case, rhesus monkey.", "Initial analysis of the relevant alpha-ENaC mRNA sequence revealed few sequences can be identified that fulfil the specificity requirements and at the same time target alpha-ENaC mRNA in all relevant species.", "Therefore it was decided to design independent screening sets for the therapeutic siRNA and for the surrogate molecules to be tested in the relevant disease model (Tables 1A,1B,1C and 1D).", "All siRNAs recognize the human alpha-ENaC sequence, as a human cell culture system was selected for determination of in vitro activity (H441, see below).", "Therefore all siRNAs can be used to target human alpha-ENaC mRNA in a therapeutic setting.", "The therapeutic screening sets were designed to contain only siRNA sequences that are fully complementary to the human and rhesus monkey alpha-ENaC sequences.", "Design and in Silico Selection of siRNAs Targeting Alpha-ENaC (SCNN1A) siRNA design was carried out to identify siRNAs for the four previously defined sets (see above) a) “Initial screening set” b) “Extended screening set” c) “In vivo surrogate set for rat” d) “In vivo surrogate set for guinea pig” Initial Screening Set The aim for in silico selection of an initial screening set was to identify siRNAs specifically targeting human alpha-ENaC, as well as its rhesus monkey ortholog.", "The human target mRNA (NM_001038.4) was downloaded from NCBI resource (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=nucleotide)_during the complete siRNA selection procedure.", "In order to identify the alpha-ENaC rhesus (Macaca mulatta) ortholog, the human sequence was used in a blastn search at Baylor College of Medicine (http://www.hgsc.bcm.tmc.edu/blast/?organism=Mmulatta) against Mmulatta contigs as of 2004 10 01.All hit regions were extracted and assembled by the CAP assembly tool to generate a first assembly sequence.", "Further, a BLAST search was performed with the human sequence at UCSC (http://genome.ucsc.edu/cgi-bin/hgBlat?command=start&org=Rhesus&db=rheMac2&hgsid=84859356) against Rhesus freeze 12 Mar.", "2005.The scaffold hit 84554 was downloaded and used together with the first assembly sequence by CAP to generate the final consensus sequence for rhesus alpha-ENaC.", "Following extraction of all overlapping 19mer sequences out of the human mRNA, conserved 19mers were identified that had identical sequences in the assembled rhesus consensus sequence.", "Those 19mer sequences were defined as the pool of human-rhesus cross-reactive siRNA (sense) sequences, represented by 1185 19mers.", "The corresponding antisense sequences were generated and tested for specificity in human.", "For this, their predicted potential for interacting with irrelevant target mRNAs (off-target potential) was taken as parameter.", "Sequences with low off-target potential were defined as preferable and predicted to be more specific.", "For further selection, candidate siRNAs were ranked according to their predicted potential for interacting with other host sequences (here, without limitation, human).", "siRNAs with low off-target potential are assumed to be more specific in vivo.", "For predicting siRNA-specific off-target potential, the following assumptions were made: 1) off-target potential of a strand can be deduced from the number and distribution of mismatches to an off-target 2) the most relevant off-target, that is the gene predicted to have the highest probability to be silenced due to tolerance of mismatches, determines the off-target potential of the strand 3) positions 2 to 9 (counting 5′ to 3′) of a strand (seed region) may contribute more to off-target potential than rest of sequence (that is non-seed and cleavage site region) (Haley, B., and Zamore, P. D., Nat Struct Mol Biol.", "2004, 11:599).", "4) positions 10 and 11 (counting 5′ to 3′) of a strand (cleavage site region) may contribute more to off-target potential than non-seed region (that is positions 12 to 18, counting 5′ to 3′) 5) positions 1 and 19 of each strand are not relevant for off-target interactions 6) off-target potential can be expressed by the off-target score of the most relevant off-target, calculated based on number and position of mismatches of the strand to the most homologous region in the off-target gene considering assumptions 3 to 5 7) assuming potential abortion of sense strand activity by internal modifications introduced, only off-target potential of antisense strand will be relevant To identify potential off-target genes, 19mer antisense sequences were subjected to a homology search against publicly available human mRNA sequences, assumed to represent the human comprehensive transcriptome.", "To this purpose, fastA (version 3.4) searches were performed with all 19mer sequences against a human RefSeq database (available version from ftp://ftp.ncbi.nih.gov/refseq/ on Nov. 18 2005).", "FastA search was executed with parameters-values-pairs-f 30-g 30 in order to take into account the homology over the full length of the 19mer without any gaps.", "In addition, in order to ensure the listing of all relevant off-target hits in the fastA output file the parameter-E 15000 was used.", "The search resulted in a list of potential off-targets for each input sequence listed by descending sequence homology over the complete 19mer.", "To rank all potential off-targets according to assumptions 3 to 5, and by this identify the most relevant off-target gene and its off-target score, fastA output files were analyzed by a perl script.", "The script extracted the following off-target properties for each 19mer input sequence and each off-target gene to calculate the off-target score: Number of mismatches in non-seed region Number of mismatches in seed region Number of mismatches in cleavage site region The off-target score was calculated by considering assumptions 3 to 5 as follows: Off  -  target   score = number   of   seed   mismatches * 10 + number   of   cleavage   site   mismatches * 1.2 + number   of   non  -  seed   mismatches * 1 The most relevant off-target gene for each 19mer sequence was defined as the gene with the lowest off-target score.", "Accordingly, the lowest off-target score was defined as representative for the off-target potential of each siRNA, represented by the 19mer antisense sequence analyzed.", "Calculated off-target potential was used as sorting parameter (descending by off-target score) in order to generate a ranking for all human-rhesus cross-reactive siRNA sequences.", "An off-target score of 3 or more was defined as prerequisite for siRNA selection, whereas all sequences containing 4 or more G's in a row (poly-G sequences) were excluded, leading to selection of a total of 152 siRNAs targeting human and rhesus ENaC alpha (see Table 1a).", "Extended Screening Set The aim for in silico selection of the extended screening set was to identify all further siRNAs targeting human alpha-ENaC with sufficient specificity, that were excluded from the initial set due to missing cross-reactivity to rhesus.", "The remaining sequences from the pool of 19mers derived from human alpha-ENaC that have not been analyzed before were taken and the corresponding antisense sequences were generated.", "The most relevant off-target gene and its corresponding off-target scores were calculated as described in section “Initial screening set”.", "For determining cross-reactivity to mouse and guinea pig (Cavia porcellus/cobya), alpha-ENaC sequences of these species were downloaded from NCBI nucleotide database1 (accession numbers NM_011324.1 and AF071230 (full length)/DQ109811 (partial cds), respectively).", "The two guinea pig sequences were used to generate a guinea pig alpha-ENaC consensus sequence.", "Every human 19mer sequence was tested for presence in the mouse and guinea pig sequences.", "Positive sequences were assigned to the pool of human-mouse cross-reactive siRNA (sense) sequences, or human-guinea pig cross-reactive siRNA (sense) sequences.", "After exclusion of all poly-G sequences, sequences were selected with off-target scores of 3 or more as well as those with off-target scores of 2.2 or 2.4 and cross-reactivity to mouse, rhesus or guinea pig.", "The total number of siRNAs in the extended screening pool was 344 (see Table 1b).", "In Vivo Rat Surrogate Set The aim for in silico selection of the in vivo rat surrogate set was to identify all siRNAs targeting human and rat alpha-ENaC with sufficient specificity in rat.", "For identification of human-rat cross-reactive siRNAs, rat alpha-ENaC mRNA sequence was downloaded from NCBI nucleotide database (accession number, NM_031548.2), and all sequences out of the pool of human 19mers were tested for presence in the rat sequence, representing the pool of human-rat cross-reactive siRNA (sense) sequences.", "The corresponding antisense sequences were generated and tested for specificity in rat.", "For this, the most relevant off-target gene in rat and its corresponding off-target scores were calculated as described in section “Initial screening set” using the rat mRNA set (RefSeq database) instead of the human transcripts.", "After exclusion of all poly-G sequences, a ranking was generated considering the rat off-target score in first priority and the human off-target score with second priority.", "Those 48 sequences from the top of the list were finally selected representing the in vivo rat surrogate set (see Table 1c).", "In Vivo Guinea Pig Surrogate Set The aim for in silico selection of the in vivo guinea pig surrogate set was to identify all siRNAs targeting human and guinea pig alpha-ENaC that have not been selected in previous sets.", "The remaining siRNAs of the previously determined set of human-guinea pig cross-reactive siRNA (sense) sequences were ranked according to human off-target scores.", "The top 63 sequences (excluding poly-G sequences) were selected, representing the in vivo guinea pig surrogate set (see Table 1d).", "Example 2: siRNA Synthesis Synthesis of Nucleotides Comprising Natural Bases.", "As the siRNAs from the screening sets are all potentially intended for in vivo administration, siRNAs were synthesised with a modification strategy that protects the siRNAs from degradation by endo- and exonucleases in a biological environment.", "In this strategy, the 3′-ends of both strands are protected from a 3′->5′-exonucleotitic activity by a phosphorothioate linkage between the two last nucleobases at the 3′-end.", "In order to inhibit endo-nucleolytic degradation of the siRNA all pyrimidines in the sense strand of the siRNA were replaced with the corresponding 2′-O-methyl-modified ribonucleotide.", "To reduce the number of modifications in the antisense strand, which is the more active strand and therefore more sensitive to modifications, we only modified the pyrimidines in the context of previously identified major nuclease cleavage sites with 2′-O-methyl groups.", "The major cleavage sites are the following two sequence motifs: 5′-UA-3′ and 5′-CA-3′.", "Since it has also been considered to use siRNAs in formulations that potentially protect the RNAs from the nucleolytic biological environment in the lung, the same set of siRNAs were also synthesized without any protection from endonucleolytic degradation.", "Where the source of a reagent is not specifically given herein, such reagent may be obtained from any supplier of reagents for molecular biology at a quality/purity standard for application in molecular biology.", "Single-stranded RNAs were produced by solid phase synthesis on a scale of 1 μmole using an Expedite 8909 synthesizer (Applied Biosystems, Applera Deutschland GmbH, Darmstadt, Germany) and controlled pore glass (CPG, 500 Δ, Proligo Biochemie GmbH, Hamburg, Germany) as solid support.", "RNA and RNA containing 2′-O-methyl nucleotides were generated by solid phase synthesis employing the corresponding phosphoramidites and 2′-O-methyl phosphoramidites, respectively (Proligo Biochemie GmbH, Hamburg, Germany).", "These building blocks were incorporated at selected sites within the sequence of the oligoribonucleotide chain using standard nucleoside phosphoramidite chemistry such as described in Current protocols in nucleic acid chemistry, Beaucage, S. L. et al.", "(Edrs.", "), John Wiley & Sons, Inc., New York, N.Y., USA.", "Phosphorothioate linkages were introduced by replacement of the iodine oxidizer solution with a solution of the Beaucage reagent (Chruachem Ltd, Glasgow, UK) in acetonitrile (1%).", "Further ancillary reagents were obtained from Mallinckrodt Baker (Griesheim, Germany).", "Deprotection and purification of the crude oligoribonucleotides by anion exchange HPLC were carried out according to established procedures.", "Yields and concentrations were determined by UV absorption of a solution of the respective RNA at a wavelength of 260 nm using a spectral photometer (DU 640B, Beckman Coulter GmbH, Unterschleißheim, Germany).", "Double stranded RNA was generated by mixing an equimolar solution of complementary strands in annealing buffer (20 mM sodium phosphate, pH 6.8; 100 mM sodium chloride), heated in a water bath at 85-90° C. for 3 minutes and cooled to room temperature over a period of 3-4 hours.", "The annealed RNA solution was diluted to a concentration of 50 μmole double stranded RNA/L and stored at −20° C. until use.", "Example 3: siRNA Testing In Vitro The ability of the iRNA agents to inhibit expression of alpha-ENaC was tested in human cell lines in vitro, or in rats in vivo.", "The iRNA agent is transfected into the cells, e.g., by transfection, allowed to act on the cells for a certain time, e.g., 24 hours, and levels of alpha-ENaC mRNA were determined by branched-DNA analysis.", "Alternatively, the iRNA agent is administered in vivo via the intratracheal route and the inhibition of alpha-ENaC mRNA expression determined by branched-DNA analysis on the target organ.", "Complementing these direct assays, we tested the inhibition of target gene expression by RNAi agents for alpha-ENaC mRNA recombinantly expressed in mammalian host cells.", "Cell Lines.", "H441 cells were obtained from the American Type Culture Collection (ATCC-Number: HTB-174, LCG Promochem GmbH, Wesel, Germany) and were grown in RPMI 1640, 10% fetal calf serum, 100u penicillin/100 μg/mL streptomycin, 2 mM L-glutamine, 10 nM Hepes and 1 mM Sodium-Pyruvate (all from Biochrom AG, Berlin, Germany) at 37° C. under a 5% CO2/95% air atmosphere.", "Primary human bronchial epithelial cells were obtained from Cambrex (Cat # CC-2540) and were routinely grown in BEGM media with singlequots (Cambrex Cat # CC-3170 minus tri-iodothreonine).", "For polarisation and growth at air liquid interface the cells were grown in a 1:1 mixture of BEGM:DMEM supplemented with 4.5 g/L D-Glucose (Gibco BRL Cat #41965-039) and supplemented with singlequots (Cambrex Cat # CC-4175), as above but minus the tri-iodothreonine and GA1000 aliquots and in the presence of 50 μg/mL Gentamycin (Gibco Brl Cat #10131-015).", "As cells were maintained in serum-free media, trypsin neutralisation solution was used during passaging steps (Cambrex Cat # CC-5002).", "For polarisation and culture at air-liquid interface the cells were grown on semipermeable (0.4 micron) polycarbonate supports (Corning Costar Cat #3407 #3460) and cultured throughout at 37° C. under a 5% CO2/95% air atmosphere.", "Cos-1 African green monkey kidney cells (ATCC # CRL-1650) were grown in Dulbecco's MEM, 4.5 g/L glucose, 10% fetal bovine serum, 2 mM L-glutamine, 1.5 g/L sodium bicarbonate (Gibco BRL), 100u penicillin/100 μg/mL streptomycin.", "Example 3.1: In Vitro Screen for Active Alpha-ENaC siRNAs and IC50 Determination in H441 One day prior to transfection, ENaC-alpha expression was induced in H441 cells (ATCC-Number: HTB-174, LCG Promochem GmbH, Wesel, Germany) by adding 100 nM of dexamthasone.", "Directly before transfection, cells were seeded at 1.5×104 cells/well on 96-well plates (Greiner Bio-One GmbH, Frickenhausen, Germany) in 75 μL of growth medium (RPMI 1640, 10% fetal calf serum, 100u penicillin/100 μg/ml streptomycin, 2 mM L-glutamine, 10 nM Hepes and 1 mM Sodium-Pyruvate, all from Biochrom AG, Berlin, Germany).", "Transfections were performed in quadruplicates.", "For each well 0.5 μL Lipofectamine2000 (Invitrogen GmbH, Karlsruhe, Germany) were mixed with 12 μL Opti-MEM (Invitrogen) and incubated for 15 min at room temperature.", "For the siRNA concentration being 50 nM in the 100 μL transfection volume, 1 μL of a 5 μM siRNA were mixed with 11.5 μL Opti-MEM per well, combined with the Lipofectamine2000-Opti-MEM mixture and again incubated for 15 minutes at room temperature.", "siRNA-Lipofectamine2000-complexes were applied completely (25 μL each per well) to the cells and cells were incubated for 24 h at 37° C. and 5% CO2 in a humidified incubator (Heraeus GmbH, Hanau).", "Cells were harvested by applying 50 μL of lysis mixture (content of the QuantiGene bDNA-kit from Genospectra, Fremont, USA) to each well containing 100 μL of growth medium and were lysed at 53° C. for 30 min.", "Afterwards, 50 μL of the lysates were incubated with probesets specific to human ENaC-alpha and human GAPDH (sequence of probesets see below) and proceeded according to the manufacturer's protocol for QuantiGene.", "In the end chemoluminescence was measured in a Victor2-Light (Perkin Elmer, Wiesbaden, Germany) as RLUs (relative light units) and values obtained with the hENaC probeset were normalized to the respective GAPDH values for each well.", "Values obtained with siRNAs directed against ENaC-alpha were related to the value obtained with an unspecific siRNA (directed against HCV) which was set to 100%.", "The percentage residual expression of alpha-ENaC for siRNA examples is shown in Tables 1A-1D.", "Effective siRNAs from the screen were further characterized by dose response curves.", "Transfections of dose response curves were performed at the following concentrations: 100 nM, 16.7 nM, 2.8 nM, 0.46 nM, 77 picoM, 12.8 picoM, 2.1 picoM, 0.35 picoM, 59.5 fM, 9.9 fM and mock (no siRNA) and diluted with Opti-MEM to a final concentration of 12.5 μl according to the above protocol.", "Data analysis was performed using Microsoft Excel add-in software XL-fit 4.2 (IDBS, Guildford, Surrey, UK) and applying the sigmoidal model number 606.Probesets: human alpha-ENaC: SEQ.", "ID.", "FPL Name Members Function Sequence NO: hENAC001 .235.255.CE CE gtctgtccagggtttccttccTTTTTctcttggaaagaaagt 1645 hENAC002 .274.293.CE CE actgccattcttggtgcagtTTTTTctcttggaaagaaagt 1646 hENAC003 .344.367.CE CE ctctcctggaagcaggagtgaataTTTTTctcttggaaagaaagt 1647 hENAC004 .391.411.CE CE gccgcggatagaagatgtaggTTTTTctcttggaaagaaagt 1648 hENAC005 .501.521.CE CE gcacttggtgaaacagcccagTTTTTctcttggaaagaaagt 1649 hENAC006 .539.560.CE CE agcagagagctggtagctggtcTTTTTctcttggaaagaaagt 1650 hENAC007 .256.273.LE LE cgccataatcgcccccaaTTTTTaggcataggacccgtgtct 1651 hENAC008 .368.390.LE LE cacagccacactccttgatcatgTTTTTaggcataggacccgtgtct 1652 hENAC009 .412.431.LE LE acagtactccacgttctgggTTTTTaggcataggacccgtgtct 1653 hENAC010 .455.477.LE LE ggagcttatagtagcagtacccaTTTTTaggcataggacccgtgtct 1654 hENAC011 .522.538.LE LE acgctgcatggcttccgTTTTTaggcataggacccgtgtct 1655 hENAC012 .561.580.LE LE gagggccatcgtgagtaaccTTTTTaggcataggacccgtgtct 1656 hENAC013 .214.234.BL BL Tcatgctgatggaggtctcca 1657 hENAC014 .294.318.BL BL Ggtaaaggttctcaacaggaacatc 1658 hENAC015 .319.343.BL BL Cacacctgctgtgtgtactttgaag 1659 hENAC016 .432.454.BL BL Caggaactgtgctttctgtagtc 1660 hENAC017 .478.500.BL BL Gtggtctgaggagaagtcaacct 1661 hENAC018 .581.599.BL BL Ccattcctgggatgtcacc 1662 human GAPDH: FPL SEQ.", "ID.", "Name Members Function Sequence NO: hGAP001 AF261085.252.271.CE CE gaatttgccatgggtggaatTTTTTctcttggaaagaaagt 1663 hGAP002 AF261085.333.352.CE CE ggagggatctcgctcctggaTTTTTctcttggaaagaaagt 1664 hGAP003 AF261085.413.431.CE CE ccccagccttctccatggtTTTTTctcttggaaagaaagt 1665 hGAP004 AF261085.432.450.CE CE gctcccccctgcaaatgagTTTTTctcttggaaagaaagt 1666 hGAP005 AF261085.272.289.LE LE agccttgacggtgccatgTTTTTaggcataggacccgtgtc 1667 t hGAP006 AF261085.290.310.LE LE gatgacaagcttcccgttctcTTTTTaggcataggacccgt 1668 gtct hGAP007 AF261085.311.332.LE LE agatggtgatgggatttccattTTTTTaggcataggacccgt 1669 gtct hGAP008 AF261085.353.372.LE LE gcatcgccccacttgattttTTTTTaggcataggacccgtgt 1670 ct hGAP009 AF261085.373.391.LE LE cacgacgtactcagcgccaTTTTTaggcataggacccgt 1671 gtct hGAP010 AF261085.451.472.LE LE gcagagatgatgacccttttgTTTTTaggcataggaccc 1672 gtgtct hGAP011 AF261085.392.412.BL BL Ggtgaagacgccagtggactc 1673 The IC50s for siRNA examples is shown in Table 2A and 2B.", "Example 3.2: Transient Alpha-ENaC Knockdown in a Primary Human Bronchial Epithelial Model Human bronchial epithelial cells (donor reference 4F1499) were plated in 24-well plates at 1×105 cells per well in 0.5 mL growth medium one day before transfection.", "The cells were 70% confluent on the day of siRNA transfection.", "Each siRNA was resuspended at 100 nM in 1 mL of Optimem I (Invitrogen) and in a separate tube, Lipofectamine 2000 (Invitrogen) was diluted to 6 μL/mL in Optimem, giving an amount sufficient for transfection of four replicates in a 24-well plate.", "After 5 minutes at room temperature, the mixtures were combined to give the desired final concentration of 50 nM siRNA and 3 μL/mL Lipofectamine 2000.The transfection mixture was incubated for a further 20 minutes at room temperature and 420 μL of the siRNA/reagent complex was added to each well as dictated by the experimental design.", "Plates were gently rocked to ensure complete mixing and then incubated at 37° C. in an incubator at 5% CO2/95% air for 4 hours.", "Subsequently, the transfection mixture was aspirated and the cells were returned to normal culture conditions for a further 20 hours.", "Cell lysates were prepared for branched-DNA analysis.", "A 2:1 medium:lysis buffer (Panomics) mixture was prepared and cells were lysed in 2004 at 53° C. for 30 minutes.", "After a visual check for complete lysis, the cell lysates were stored at −80° C. for subsequent analysis.", "Branched-DNA analysis was performed as described above, with alpha-ENaC expression normalized against GAPDH.", "The branched DNA analysis protocol used differs from that above only in that 20 μL of sample was applied to each well in this case.", "Table 2C shows the alpha-ENaC expression in primary HBEC for siRNA examples.", "Example 3.3: In Vitro Inhibition of Exogenously Expressed Cloned Cynomolgous Alpha-ENaC Gene Expression for Selected RNAi Agents in Cos-1 Cells Cloning of the Cynomolgous Alpha-ENaC Sequence.", "Primer sequences for amplification of 5′-UTR and CDS (nucleotides shown in brackets correspond to the Macaca mulatta (Rhesus monkey) α-ENaC cDNA sequence): (SEQ.", "I. D. NO: 1674) P745: 5′- CTCCATGTTCTGCGGCCGCGGATAGAAG-3′ (nt 1427) (SEQ.", "I. D. NO: 1675) P733: 5′- CCGGCCGGCGGGCGGGCT-3′ (nt 1) (SEQ.", "I. D. NO: 1676) P734: 5- CTCCCCAGCCCGGCCGCT-3′ (nt 17) (SEQ.", "I. D. NO: 1677) P735: 5′- GGCCGCTGCACCTGTAGGG-3′ (nt 28) Primer sequences for amplification of CDS and 3′-UTR: (SEQ.", "I. D. NO: 1678) P737: 5′- ATGGAGTACTGTGACTACAGG-3′ (nt 1422) (SEQ.", "I. D. NO: 1679) P740: 5′- TTGAGCATCTGCCTACTTG-3′ (nt 3113) Primer sequences for amplification of internal part of CDS: (SEQ.", "I. D. NO: 1679) P713: 5′- 5′-ATGGATGATGGTGGCTTTAACTTGCGG-3′ (nt 1182) (SEQ.", "I. D. NO: 1680) P715: 5′- 5′-TCAGGGCCCCCCCAGAGG-3′ (nt 2108) Cynomolgus (Macaca fascicularis) lung total RNA (#R1534152-Cy-BC) was purchased from BioCat (Germany).", "Synthesis of cDNA was performed using the SuperScript III First Strand Synthesis System (Invitrogen).", "Synthesis of cDNA was performed using either random hexamers or oligo dT primers.", "In addition, cynomolgus lung first strand cDNA was also purchased from BioCat/#C1534160-Cy-BC).", "For PCR amplification, the Advantage 2 PCR kit (# K1910-1, Clontech) was used.", "Amplification of the 5′-UTR and parts of the CDS was performed using P745 and a equimolar mixture of P733, P734 and P735.For PCR amplification of the CDS and 3′-UTR, primers P737 and P740 were used.", "The primers P713 and P715 were used for amplification of parts of the CDS.", "All PCR products were analysed by agarose gel electrophoresis and then cloned into the pCR2.1 vector using the TOPO TA cloning kit (Invitrogen) in TOP10 bacteria.", "Clones were then picked and DNA was isolated using the Qiagen Miniprep kit.", "After restriction enzyme digest with EcoRI and analysis by agarose gel electrophoresis, DNA from correct clones were subjected to sequencing.", "The sequences were then aligned with the α-ENaC cDNA sequence of Rhesus monkey, and sequences of the individual clones were aligned with each other.", "The full-length cynomolgus alpha-ENaC cDNA was then cloned by digestion of the 5′-part (5′-UTR and CDS, clone 55) with EcoR I and Not I, digestion of the middle part of the CDS by Not I and BstE II (clone 15), and the 3′-part (CDS and 3′-UTR) by BstE II and EcoR V (clone 80).", "The digested DNA fragments were then subcloned into pcDNA3.1, digested with EcoR I and EcoR V. The full-length cynomolgus alpha-ENaC cDNA in pcDNA3.1 was then subjected to full-length sequencing (Ingenetix, Vienna, Austria).", "The cynomolgus alpha-ENaC cDNA sequence corresponds to nt 28-3113 of the Rhesus alpha-ENaC cDNA sequence.", "Finally the cynomolgus alpha-ENaC cDNA was then excised from pcDNA3.1-cynomolgus alpha-ENaC by digestion with BamH I and EcoR V and subcloned into the vector pXOON.", "The plasmid map is illustrated in FIG.", "1.FIG.", "2 depicts the protein (SEQ.I.D.NO:1681) and DNA (SEQ.I.D.NO:1682) sequence of cynomolgous alpha-ENaC.", "Transfections: COS-1 cells were seeded at 6×104 cells/well on 24 well plates each in 0.5 mL of growth medium.", "One day after seeding the cells were co-transfected with the pXOON cynomolgous alpha-ENaC expression plasmid and the indicated siRNA.", "For each well, 4 ng of alpha-ENaC expression plasmid and 600 ng carrier plasmid (pNFAT-luc) were co-transfected with the relevant siRNA (final concentration 45 nM) using X-treme gene transfection reagent (Roche) at 3.75 μL/well in a total volume of 720 μL/well Opti-MEM (Invitrogen) as described below.", "Transfections were performed in triplicate for each sample.", "Plasmid/siRNA mastermixes (each for 3.5 wells) were prepared as follows: 14 ng alpha-ENaC expression plasmid, 2.1 μg carrier plasmid and 112 pmoles of relevant siRNA in a total volume 210 μL (Opti-MEM).", "A lipid mastermix was prepared for the whole transfection (105 μL lipid plus 1575 μL Opti-MEM for eight triplicate transfection samples).", "Plasmid/siRNA and lipid were mixed in equal volume to give a total volume of 420 μL transfection mix per triplicate sample (3.5×).", "Following a 20 minute incubation at room temperature, 120 μL of the relevant transfection mix was added to each well of cells in a final transfection volume of 720 μL (Opti-MEM).", "Cells were transfected for 24 hours at 37° C. and 5% CO2 in a humidified incubator (Heraeus GmbH, Hanau, Germany) and harvested for branched-DNA analysis.", "Cell lysates were prepared for branched DNA analysis.", "A 2:1 medium:lysis buffer (Panomics) mixture was prepared and cells were lysed in 200 μL at 53° C. for 30 minutes.", "After a visual check for complete lysis, the cell lysates were stored at −80° C. for subsequent analysis.", "Branched-DNA analysis was performed as described above, with cyno alpha-ENaC expression normalized against eGFP from the expression plasmid.", "The branched-DNA analysis protocol used differs from that above only in that 20 μL of sample was applied to each well in this case.", "Probesets: cynomolgous alpha-ENaC: FPL Name Function Sequence SEQ ID NO: cyENa001 CE cgccgtgggctgctgggTTTTTctcttggaaagaaagt 1683 cyENa002 CE ggtaggagcggtggaactcTTTTTctcttggaaagaaagt 1684 cyENa003 CE cagaagaactcgaagagctctcTTTTTctcttggaaagaaagt 1685 cyENa004 CE cccagaaggccgtcttcatTTTTTctcttggaaagaaagt 1686 cyENa005 LE ggtgcagagccagagcactgTTTTTctcttggaaagaaagt 1687 cyENa006 LE gtgccgcaggttctgggTTTTTaggcataggacccgtgtct 1688 cyENa007 LE gatcagggcctcctcctcTTTTTaggcataggacccgtgtct 1689 cyENa008 LE ccgtggatggtggtattgttgTTTTTaggcataggacccgtgtct 1690 cyENa009 LE gcggttgtgctgggagcTTTTTaggcataggacccgtgtct 1691 cyENa0010 LE ttgccagtacatcatgccaaaTTTTTaggcataggacccgtgtct 1692 cyENa0011 BL acaccaggcggatggcg 1693 eGFP: FPL Name Function Sequence SEQ ID NO: EGFP001 CE ggcacgggcagcttgcTTTTTctcttggaaagaaagt 1694 EGFP002 CE ggtagcggctgaagcactgTTTTTctcttggaaagaaagt 1695 EGFP003 CE cctggacgtagccttcgggTTTTTctcttggaaagaaagt 1696 EGFP004 CE ccttgaagaagatggtgcgctTTTTTctcttggaaagaaagt 1697 EGFP005 LE cgaacttcacctcggcgcTTTTTctcttggaaagaaagt 1698 EGFP006 LE ccttcagctcgatgcggtTTTTTctcttggaaagaaagt 1699 EGFP007 LE gtcacgagggtgggccagTTTTTaggcataggacccgtgtct 1700 EGFP008 LE cacgccgtaggtcagggtgTTTTTaggcataggacccgtgtct 1701 EGFP009 LE gtgctgcttcatgtggtcggTTTTTaggcataggacccgtgtct 1702 EGFP0010 LE tcaccagggtgtcgccctTTTTTaggcataggacccgtgtct 1703 EGFP0011 BL cggtggtgcagatgaacttca 1704 EGFP0012 BL catggcggacttgaagaagtc 1705 EGFP0013 BL cgtcctccttgaagtcgatgc 1706 Table 2C shows the alpha-ENaC expression in cynomologous species for siRNA examples.", "Example 3.4 Screening for Interferon-α Induction To evaluate the ability of siRNA to stimulate interferon-α (IFNα) release, siRNA was incubated with freshly purified peripheral blood mononuclear cells (PBMCs) in vitro for 24 hours.", "The siRNA was added either directly to PBMCs, or first complexed with a lipid transfection agent (GenePorter 2 or Lipofectamine 2000 or DOTAP transfection agent) and subsequently incubated with PBMCs.", "As positive controls for IFNα induction, unmodified control sequences DI_A_2216 and DI_A_5167 were included.", "DI_A_2216: is a single-stranded antisense DNA molecule (SEQ ID NO: 1707) 5′-dGsdGsdGdGdGdAdCdGdAdTdCdGdTdCdGsdGsdGsdGsdGsd G -3′ DI_A_5167 is a cholesterol-conjugated siRNA 5′- GUCAUCACACUGAAUACCAAU-s-chol - 3′ (SEQ ID NO: 1708) 3′- CsAsCAGUAGUGUGACUUAUGGUUA-5′ After 24 hours, the IFNα was measured by ELISA.", "The basal IFNα level was determined for untreated cells and was always very close to a water-only control.", "The addition of transfection agent alone gave no or little increase of IFNα levels.", "Known stimulatory oligonucleotides were added to cells, either directly or in the presence of transfectant, and the expected increases of IFNα were observed.", "This setup allows to determine the stimulation of IFNα in human PBMC by siRNA (or other oligonucleotides).", "Isolation of Human PBMCs: A concentrated fraction of leukocytes (buffy coat) was obtained from the Blood Bank Suhl, Institute for Transfusion Medicine, Germany.", "These cells were negative for a variety of pathogens, including HIV, HCV, and others.", "The buffy coat was diluted 1:1 with PBS, added to a tube containing Ficoll, and centrifuged for 20 minutes at 2200 rpm to allow fractionation.", "This was followed by removal of the turbid layer of white blood cells and transferred to a tube with fresh PBS and Ficoll, which was centrifuged for 15 minutes at 2200 rpm.", "The turbid layer of white blood cells was again removed, transferred to RPMI 1640 culture medium and centrifuged for 5 minutes at 1,200 rpm to pellet the white blood cells.", "The cells were resuspended in RPMI, pelleted as above, and resuspended in media with 10% FCS to 1×106/mL.", "Interferon-α Measurement: Cells in culture were combined with either 500 nM (or 1 μM) oligonucleotide in Optimem or 133 nM oligonucleotide in GP2 or Lipofectamine2000 or DOTAP transfection agent for 24 hours at 37° C. Interferon-α was measured with Bender Med Systems (Vienna, Austria) instant ELISA kit according to the manufacturer's instructions.", "Selection of lead therapeutic sequences was based on a level of IFNα induction of less than 15% of the positive control.", "Example 3.5 Determination of siRNA Stability in Sputum of CF Patients Sputum samples were collected by Dr. Ahmet Uluer, Children's Hospital Boston.", "After collection, sputum samples were treated with antibiotic and were UV-irradiated to reduce bacterial content.", "To determine siRNA stability in sputum samples, siRNAs were incubated in 30 μL sputum at a concentration of 5 μM at 37° C. for the indicated times.", "The reaction was terminated by addition of proteinase K and samples were incubated at 42° C. for another 20 minutes.", "A 40-mer RNA molecule made of L-nucleotides (“Spiegelmer”) resistant to nuclease degradation was added and served as calibration standard.", "Samples were filtered through a 0.2 μm membrane to remove remaining debris.", "Samples were analyzed by denaturing ion exchange HPLC on a DNAPac PA 200 column (Dionex) at pH 11.0 using a gradient of sodium perchlorate for elution.", "siRNAs and degradation products were quantified by determination of the area under the peak for each sample.", "Concentration was normalized to the concentration in the un-incubated samples.", "The selection of the lead therapeutic sequences (ND8356, ND8357 and ND8396) was based on an observed in vitro stability in CF sputum with a half-life greater than 60 minutes.", "Example 3.6 Cross-Checking of Lead Therapeutic Sequences Against Known Polymorphisms in Human SCNN1A Gene To exclude known polymorphisms from the target sites of lead candidates, lead siRNA sequences were checked against the NCBI single nucleotide polymorphism (SNP) database (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?", "CMD=search&DB=snp).", "Of the 10 known exon polymorphisms in the human SCNN1A gene, none were shown to be present in the target sites of any of the 10 most potent lead therapeutic candidates.", "Example 3.7: In Vitro Profiling of Top 5 Predicted Off-Target Sequences A list of alignments for each sequence was sorted by homology over the 19-mer region.", "Off-targets were scored based on the number and position of the mismatches in accordance with the criteria described in example 1.The top 5 off-target sequences were identified for each lead therapeutic sequences (ND8356, ND8357 and ND8396).", "On- and off-target sequences were individually cloned into a dual luciferase reporter system.", "Each cloned fragment encompassed the target 19 nucleotides in addition to 10 nucleotides flanking region, both 5′ and 3′ of the target sequence.", "The fragments were cloned into a multiple cloning site 3′ to the Renilla luciferase sequence, under the control of an SV40 promoter.", "The activity of each siRNA against both on- and off-target sequences was determined by the relative fluorescence of the target Renilla luciferase to the Firefly luciferase, the latter being independently controlled by the HSV-TK promoter.", "Initially, transfections were performed in COS-7 cells at an siRNA concentration of 50 nM.", "Luciferase readouts were taken at 24 h post-transfection.", "At this high concentration of siRNA, no knockdown of greater than 30% was observed against any off-target sequence for any of the three lead siRNAs.", "Activity against the on-target sequence was demonstrated with a relative reduction in Renilla luciferase activity of approximately 80%.", "IC50 curves were also generated for each siRNA against the on-target sequence and controlled with the off-target sequences identified above.", "For each lead siRNA, on-target IC50's in this reporter assay were of similar order of magnitude (10-50 pM) to the IC50's obtained against the endogenous target in H441 (Example 3.3) indicating that for ND8356, ND8357 and ND8396, potency against the on-target sequence was at least 1000-5000 fold higher than for any of the predicted off-target sequences.", "Example 3.8: Genotoxicity Profiling Cytotoxicity determination: Cytotoxicity was determined by using a cell counter for the assessment of culture cell number.", "It is well known that testing cytotoxic concentrations in vitro may induce genotoxic effects such as micronucleus formation.", "Therefore, we considered increased numbers of cells containing micronuclei appearing at cell counts of around 50% or less (compared to the concurrent negative control) to be cytotoxicity-related if no dose-dependent increase in micronucleated cells could already be observed at concentrations showing moderate toxicity at most.", "The analysis of a concentration showing at least 50% reduction in cell count is required by the guidelines regulating in vitro mammalian cell assays (OECD and ICH guidelines for the conduction of chromosome aberration testing).", "In addition, OECD protocols require testing of non-toxic compounds to include at least one precipitating concentration (as long as this doesn't exceed 10 mM or 5 mg/ml, whichever is lower).", "Since the in vitro micronucleus test aims to predict the outcome of the regulatory assays, i.e.", "in vitro chromosomal aberration test, the protocol for the in vitro micronucleus test was designed to meet the requirements for these tests.", "Test system: TK6 cells are Ebstein-Barr-Virus transfected and immortalized cells (human lymphoblastoid origin derived from the spleen).", "Determination of the clastogenic and/or aneugenic potential in the micronucleus test in vitro with TK6 cells with/without S9-liver homogenate (2%) from male rats (Aroclor 1254-pretreated).", "Treatment time: 20 hr (−S9), 3 hr (+S9).", "Sampling time: 24 hr after the start of 3-hour treatment, 48 hr after the start of 20-hour treatment.", "For each substance at least three concentrations (2 cultures per concentration) and 2000 cells per concentration were analyzed.", "The micronucleus inducing effect for a tested concentration was considered positive if the frequency of micronucleated cells was >=2% and showed at least a doubling of the concurrent solvent control value, OR <2% and showed at least a 3-fold increase over the concurrent solvent control value To conclude an experiment to be positive, dose-effect relationship and cytotoxicity have to be taken into account.", "Summary: Lead therapeutic sequences ND8396, ND8356, ND8357 neither induced increased numbers of cells containing micronuclei after 20-hour treatment without metabolic activation, nor after 3-hour treatment with or without S9.No cytotoxic concentration could be analyzed up to the testing limit of 5 mg/ml.", "Example 3.9 In Vitro Functional Efficacy in H441: ND8396 In order to demonstrate in vitro functional efficacy of lead siRNA against alphaENaC H441 cells were transfected with siRNA and prepared for Ussings chamber analysis of ion transport.", "For transfection, H441 cells were plated into T25 flasks at 2×106 cells per flask in culture medium supplemented with 200 nM Dexamethasone.", "Cells in each flask were transfected with either ND8396 or a non targeting control siRNA at 30 nM siRNA and 4 mL/mL Lipofectamine 2000 in a total volume of 5 mL (serum free medium).", "One day after transfection, cells were plated onto 1 cm2 Snapwell inserts at confluency (2×105 cells per insert) to minimise the time required for differentiation and formation of tight junctions and supplied with medium in both the apical and the basolateral chambers.", "After one additional day of culture the apical medium was removed and the basolateral medium replaced, thus taking the cells to air-liquid interface (ALI) culture.", "Cells were maintained at ALI for a further six days prior to ion transport analysis.", "For functional analysis in Ussings chambers, the Snapwell inserts were mounted in Vertical Diffusion Chambers (Costar) and were bathed with continuously gassed Ringer solution (5% CO2 in 02; pH 7.4) maintained at 37° C. containing: 120 mM NaCl, 25 mM NaHCO3, 3.3 mM KH2PO4, 0.8 mM K2HPO4, 1.2 mM CaCl2, 1.2 mM MgCl2, and 10 mM glucose.", "The solution osmolarity was determined within the range of 280 and 300 mosmol/kgH2O.", "Cells were voltage clamped to 0 mV (model EVC4000; WPI).", "Transepithelial resistance (RT) was measured by applying a 1 or 2-mV pulse at 30-s intervals, or using the initial potential difference across the cells and the initial current measured, and then calculating RT by Ohm's law.", "Data were recorded using a PowerLab workstation (ADInstruments).", "Following siRNA treatment the basal characteristics of the cells and the amiloride-sensitive short circuit current (ISC following application of 10 μM amiloride; apical side only) were recorded.", "ENaC channel activity in each culture was determined by the amiloride-sensitive ISC in each case.", "Following assay, cells on the individual inserts were lysed for RNA analysis.", "A knockdown of 75% at the RNA level at the time of assay (ND8396 as compared to non-targeting control) was correlated with a functional knockdown of the amiloride sensitive current of approximately 30% (ND8396 as compared to non-targeting control).", "Nucleic acid sequences are represented below using standard nomenclature, and specifically the abbreviations of Table A.", "TABLE A Abbreviations of nucleotide monomers used in nucleic acid sequence representation.", "It will be understood that these monomers, when present in an oligonucleotide, are mutually linked by 5′-3′-phosphodiester bonds.", "Abbreviationa Nucleotide(s) A adenosine-5′-phosphate C cytidine-5′-phosphate G guanosine-5′-phosphate T 2′-deoxy-thymidine-5′-phosphate U uridine-5′-phosphate c 2′-O-methylcytidine-5′-phosphate u 2′-O-methyluridine-5′-phosphate Ts 2′-deoxy-thymidine-5′-phosphorothioate TABLE 1A Selected siRNAs in initial screening set (human-rhesus ENaC alpha cross- reactive siRNAs).", "A total of 152 iRNA sequences were identified as an initial screening set, both with (sequence strands 1-304) and without (sequence strands 305-608) backbone modification.", "iRNA sequences were designed to be fully complementary to both the human and rhesus monkey alpha-ENaC sequences, according to the design criteria described in the examples section.", "The percentage residual expression of alpha-ENaC in two independent single-dose transfection experiments is shown (refer to examples section for methods used).", "1st screen single dose @ 50 2nd screen Seq Seq nm in @ 50 nM in Duplex ID ID Sense ID Antissense H441; MV ED H441 SD ND8285 1 AGcccGuAGcGuGGccuccTsT 2 GGAGGCcACGCuACGGGCUTsT 92% 4% 114% 15% ND8286 3 ccGGGuAAuGGuGcAcGGGTsT 4 CCCGUGcACcAUuACCCGGTsT 60% 1% 84% 4% ND8287 5 AuGcuAucGcGAcAGAAcATsT 6 UGUUCUGUCGCGAuAGcAUTsT 27% 2% 35% 3% ND8288 7 uGcuAucGcGAcAGAAcAATsT 8 UUGUUCUGUCGCGAuAGcATsT 23% 1% 32% 4% ND8289 9 GcccGuuuAuGuAuGcuccTsT 10 GGAGcAuAcAuAAACGGGCTsT 64% 2% 93% 8% ND8290 11 GcccGuAGcGuGGccuccATsT 12 UGGAGGCcACGCuACGGGCTsT 83% 2% 115% 8% ND8291 13 ccGGAAAuuAAAGAGGAGcTsT 14 GCUCCUCUUuAAUUUCCGGTsT 54% 2% 79% 18% ND8292 15 ccGAAGGuuccGAAGccGATsT 16 UCGGCUUCGGAACCUUCGGTsT 40% 1% 54% 8% ND8293 17 GcAAuucGGccuGcuuuucTsT 18 GAAAAGcAGGCCGAAUUGCTsT 41% 2% 51% 4% ND8294 19 GGcGAAuuAcucucAcuucTsT 20 GAAGUGAGAGuAAUUCGCCTsT 19% 1% 25% 5% ND8295 21 GcGAAuuAcucucAcuuccTsT 22 GGAAGUGAGAGuAAUUCGCTsT 19% 5% 20% 1% ND8296 23 AAccAGGcGAAuuAcucucTsT 24 GAGAGuAAUUCGCCUGGUUTsT 92% 4% 115% 19% NC8297 25 GGuAAuGGuGcAcGGGcAGTsT 26 CUGCCCGUGcACcAUuACCTsT 78% 2% 108% 18% ND8298 27 cucAcGAuGGcccucGGuGTsT 28 cACCGAGGGCcAUCGUGAGTsT 61% 3% 97% 18% ND8299 29 GcuccGAAGGuuccGAAGuTsT 30 GCUUCGGAACCUUCGGAGCTsT 16% 2% 19% 3% ND8300 31 GccGAuAcuGGucuccAGGTsT 32 CCUGGAGACcAGuAUCGGCTsT 68% 5% 55% 5% ND8301 33 ccGAuAcuGGucuccAGGcTsT 34 GCCUGGAGACcAGuAUCGGTsT 63% 2% 65% 6% ND8302 35 uGcuGuuGcAccAuAcuuuTsT 36 AAAGuAUGGUGcAAcAGcATsT 19% 2% 25% 3% ND8303 37 AAcGGucuGucccuGAuGcTsT 38 GcAUcAGGGAcAGACCGUUTsT 30% 3% 96% 11% ND8304 39 uuAAcuuGcGGccuGGcGuTsT 40 ACGCcAGGCCGcAAGUuAATsT 37% 3% 101% 11% ND8305 41 GcuGGuuAcucAcGAuGGcTsT 42 GCcAUCGUGAGuAACcAGCTsT 73% 2% 78% 7% ND8306 43 uuAcucAcGAuGGcccucGTsT 44 CGAGGGCcAUCGUGAGuAATsT 91% 7% 93% 6% ND8307 45 GAAGccGAuAcuGGucuccTsT 46 GGAGACcAGuAUCGGCUUCTsT 71% 3% 73% 6% ND8308 47 GAuAcuGGucuccAGGccGTsT 48 CGGCCUGGAGACcAGuAUCTsT 86% 1% 80% 9% ND8309 49 AuAcuGGucuccAGGccGATsT 50 UCGGCCUGGAGACcAGuAUTsT 71% 5% 70% 8% ND8310 51 cAAcGGucuGucccuGAuGTsT 52 cAUcAGGGAcAGACCGUUGTsT 80% 2% 84% 9% ND8311 53 uuuAAcuuGcGGccuGGcGTsT 54 CGCcAGGCCGcAAGUuAAATsT 95% 2% 107% 15% ND8312 55 uAcucAcGAuGGcccucGGTsT 56 CCGAGGGCcAUCGUGAGuATsT 44% 2% 97% 9% ND8313 57 uuucGGAGAGuAcuucAGcTsT 58 GCUGAAGuACUCUCCGAAATsT 14% 2% 16% 2% ND8314 59 GcAGAcGcucuuuGAccuGTsT 60 cAGGUcAAAGAGCGUCUGCTsT 55% 4% 58% 5% ND8315 61 cuAcAucuucuAuccGcGGTsT 62 CCGCGGAuAGAAGAUGuAGTsT 20% 3% 26% 4% ND8316 63 AGGcGAAuuAcucucAcuuTsT 64 AAGUGAGAGuAAUUCGCCUTsT 24% 1% 25% 2% ND8317 65 ccGcuucAAccAGGUCUCCTsT 66 GGAGACCUGGUUGAAGCGGTsT 62% 5% 64% 4% ND8318 67 cAAccGcAuGAAGAcGGccTsT 68 GGCCGUCUUcAUGCGGUUGTsT 54% 6% 54% 4% ND8319 69 AuGAAGAcGGccuucuGGGTsT 70 CCcAGAAGGCCGUCUUcAUTsT 44% 4% 44% 6% ND8320 71 AGcAcAAccGcAuGAAGAcTsT 72 GUCUUcAUGCGGUUGUGCUTsT 15% 1% 16% 1% ND8321 73 ucGAGuuccAccGcuccuATsT 74 uAGGAGCGGUGGAACUCGATsT 85% 5% 89% 13% ND8322 75 cuGcuucuAccAGAcAuAcTsT 76 GuAUGUCUGGuAGAAGcAGTsT 46% 4% 44% 3% ND8323 77 GAGGGAGuGGuAccGcuucTsT 78 GAAGCGGuACcACUCCCUCTsT 60% 7% 56% 3% ND8324 79 ccuuuAuGGAuGAuGGuGGTsT 80 CcACcAUcAUCcAuAAAGGTsT 83% 9% 82% 1% ND8325 81 uGAGGGAGuGGuAccGcuuTsT 82 AAGCGGuACcACUCCCUcATsT 77% 6% 72% 2% ND8326 83 ccuGcAAccAGGcGAAuuATsT 84 uAAUUCGCCUGGUUGcAGGTsT 41% 4% 44% 7% ND8327 85 GGccuGGcGuGGAGAccucTsT 86 GAGGUCUCcACGCcAGGCCTsT 101% 5% 95% 4% ND8328 87 uGcuuuucGGAGAGuAcuuTsT 88 AAGuACUCUCCGAAAAGcATsT 36% 1% 29% 2% ND8329 89 cccGuAGcGuGGccuccAGTsT 90 CUGGAGGCcACGCuACGGGTsT 52% 1% 51% 2% ND8330 91 ccGuAGcGuGGccuccAGcTsT 92 GCUGGAGGCcACGCuACGGTsT 86% 9% 84% 3% ND8331 93 ccAGGcGAAuuAcucucAcTsT 94 GUGAGAGuAAUUCGCCUGGTsT 15% 2% 13% 1% ND8332 95 GAAAcuGcuAuAcuuucAATsT 96 UUGAAAGuAuAGcAGUUUCTsT 10% 1% 10% 1% ND8333 97 GcccGGGuAAuGGuGcAcGTsT 98 CGUGcACcAUuACCCGGGCTsT 83% 6% 82% 4% ND8334 99 cccGGGuAAuGGuGcAcGGTsT 100 CCGUGcACcAUuACCCGGGTsT 56% 4% 71% 10% ND8335 101 cGGGuAAuGGuGcAcGGGcTsT 102 GCCCGUGcACcAUuACCCGTsT 42% 3% 91% 8% ND8336 103 GGGuAAuGGuGcAcGGGcATsT 104 UGCCCGUGcACcAUuACCCTsT 65% 5% 71% 7% ND8337 105 uAAuGGuGcAcGGGcAGGATsT 106 UCCUGCCCGUGcACcAUuATsT 46% 3% 46% 4% ND8338 107 cuGGuuAcucAcGAuGGccTsT 108 GGCcAUCGUGAGuAACcAGTsT 74% 5% 79% 10% ND8339 109 GuuAcucAcGAuGGcccucTsT 110 GAGGGCcAUCGUGAGuAACTsT 85% 6% 92% 8% ND8340 111 uGucAcGAuGGucAcccucTsT 112 GAGGGUGACcAUCGUGAcATsT 85% 4% 74% 5% ND8341 113 uGcuccGAAGGuuccGAAGTsT 114 CUUCGGAACCUUCGGAGcATsT 37% 2% 32% 3% ND8342 115 uccGAAGGuuccGAAGccGTsT 116 CGGCUUCGGAACCUUCGGATsT 60% 4% 47% 5% ND8343 117 uuccGAAGccGAuAcuGGuTsT 118 ACcAGuAUCGGCUUCGGAATsT 15% 1% 13% 2% ND8344 119 AGccGAuAcuGGucuccAGTsT 120 CUGGAGACcAGuAUCGGCUTsT 49% 3% 41% 3% ND8345 121 cuuGGuAcuGccucuGAAcTsT 122 GUUcAGAGGcAGuACcAAGTsT 55% 2% 47% 4% ND8346 123 cucccGuAGcAcAcuAuAATsT 124 UuAuAGUGUGCuACGGGAGTsT 67% 3% 57% 5% ND8347 125 ucccGuAGcAcAcuAuAAcTsT 126 GUuAuAGUGUGCuACGGGATsT 29% 1% 26% 3% ND8348 127 uGcAccAuAcuuucuuGuATsT 128 uAcAAGAAAGuAUGGUGcATsT 17% 1% 15% 3% ND8349 129 uuGcccGuuuAuGuAuGcuTsT 130 AGcAuAcAuAAACGGGcAATsT 68% 2% 60% 4% ND8350 131 uGcccGuuuAuGuAuGcucTsT 132 GAGcAuAcAuAAACGGGcATsT 59% 8% 44% 6% ND8351 133 GGAcccuAGAccucuGcAGTsT 134 CUGcAGAGGUCuAGGGUCCTsT 86% 11% 82% 2% ND8352 135 ccUAGAccucuGcAGcccATsT 136 UGGGCUGcAGAGGUCuAGGTsT 69% 7% 79% 3% ND8353 137 uGGcAuGAuGuAcuGGcAATsT 138 UUGCcAGuAcAUcAUGCcATsT 58% 4% 52% 4% ND8354 139 uAcuGGcAAuucGGccuGcTsT 140 GcAGGCCGAAUUGCcAGuATsT 101% 4% 100% 4% ND8355 141 AAuucGGccuGcuuuucGGTsT 142 CCGAAAAGcAGGCCGAAUUTsT 49% 1% 43% 6% ND8356 143 cuGcuuuucGGAGAGuAcuTsT 144 AGuACUCUCCGAAAAGcAGTsT 17% 3% 18% 1% ND8357 145 uucGGAGAGuAcuucAGcUTsT 146 AGCUGAAGuACUCUCCGAATsT 13% 3% 16% 2% ND8358 147 AGcAGAcGcucuuuGAccuTsT 148 AGGUcAAAGAGCGUGUGCUTsT 73% 9% 71% 5% ND8359 149 cuuGcAGcGccuGAGGGucTsT 150 GACCCUcAGGCGCUGcAAGTsT 57% 9% 64% 7% ND8360 151 uGGcuuuAAcuuGcGGccuTsT 152 AGGCCGcAAGUuAAAGCcATsT 102% 12% 106% 10% ND8361 153 GcuuuAAcuuGcGGccuGGTsT 154 CcAGGCCGcAAGUuAAAGCTsT 83% 5% 82% 8% ND8362 155 uAACuuGcGGccuGGcGuGTsT 156 cACGCcAGGCCGcAAGUuATsT 119% 2% 115% 6% ND8363 157 AccuuuAcccuucAAAGuATsT 158 uACUUUGAAGGGuAAAGGUTsT 17% 3% 13% 2% ND8364 159 GGuuAcucAcGAuGGcccuTsT 160 AGGGCcAUCGUGAGuAACCTsT 104% 9% 117% 17% ND8365 161 cAcGAuGGcccucGGuGAcTsT 162 GUcACCGAGGGCcAUCGUGTsT 140% 13% 100% 9% ND8366 163 AGAuGcuAucGcGAcAGAATsT 164 UUCUGUCGCGAuAGcAUCUTsT 46% 2% 70% 6% ND8367 165 AcGAuGGucAcccuccuGuTsT 166 AcAGGAGGGUGACcAUCGUTsT 85% 6% 128% 10% ND8368 167 cuccGAAGGuuccGAAGccTsT 168 GGCUUCGGAACCUUCGGAGTsT 12% 2% 18% 1% ND8369 169 AAGGuuccGAAGccGAuAcTsT 170 GuAUCGGCUUCGGAACCUUTsT 63% 7% 114% 19% ND8370 171 GGuAcuGccucuGAAcAcuTsT 172 AGUGUUcAGAGGcAGuACCTsT 36% 3% 71% 6% ND8371 173 AGcuuuGAcAAGGAAcuuuTsT 174 AAAGUUCCUUGUcAAAGCUTsT 17% 1% 21% 1% ND8372 175 uuuGAcAAGGAAcuuuccuTsT 176 AGGAAAGUUCCUUGUcAAATsT 16% 2% 26% 4% ND8373 177 uGAcAAGGAAcuuuccuAATsT 178 UuAGGAAAGUUCCUUGUcATsT 12% 1% 22% 5% ND8374 179 cccGuAGcAcAcuAuAAcATsT 180 UGUuAuAGUGUGCuACGGGTsT 41% 2% 75% 3% ND8375 181 cAcuAuAAcAucuGcuGGATsT 182 UCcAGcAGAUGUuAuAGUGTsT 17% 1% 26% 2% ND8376 183 uuGcuGuuGcAccAuAcuuTsT 184 AAGuAUGGUGcAAcAGcAATsT 45% 4% 69% 6% ND8377 185 GuAcuGGcAAuucGGccuGTsT 186 cAGGCCGAAUUGCcAGuACTsT 60% 6% 120% 8% ND8378 187 uucGGccuGcuuuucGGAGTsT 188 CUCCGAAAAGcAGGCCGAATsT 57% 5% 86% 11% ND8379 189 ccuGcuuuucGGAGAGuAcTsT 190 GuACUCUCCGAAAAGcAGGTsT 43% 5% 50% 3% ND8380 191 GcuuuucGGAGAGuAcuucTsT 192 GAAGuACUCUCCGAAAAGCTsT 16% 2% 24% 2% ND8381 193 cuuuucGGAGAGuAcuucATsT 194 UGAAGuACUCUCCGAAAAGTsT 12% 1% 16% 3% ND8382 195 cAAccucAAcucGGAcAAGTsT 196 CUUGUCCGAGUUGAGGUUGTsT 33% 2% 39% 3% ND8383 197 cuAccAGAcAuAcucAucATsT 198 UGAUGAGuAUGUCUGGuAGTsT 13% 1% 23% 6% ND8384 199 cuGucGAGGcuGccAGAGATsT 200 UCUCUGGcAGCCUCGAcAGTsT 11% 1% 18% 3% ND8385 201 AAAcuGcuAuAcuuucAAuTsT 202 AUUGAAAGuAuAGcAGUUUTsT 48% 8% 64% 11% ND8386 203 GGcuuuAAcuuGcGGccuGTsT 204 cAGGCCGcAAGUuAAAGCCTsT 55% 7% 70% 8% ND8387 205 cuuuAAcuuGcGGccuGGcTsT 206 GCcAGGCCGcAAGUuAAAGTsT 40% 11% 87% 14% ND8388 207 AGGuGuGuAuucAcuccuGTsT 208 cAGGAGUGAAuAcAcACCUTsT 45% 3% 41% 5% ND8389 209 AcGAuGGcccucGGuGAcATsT 210 UGUcACCGAGGGCcAUCGUTsT 43% 2% 60% 9% ND8390 211 cuGAAcAcucuGGuuucccTsT 212 GGGAAACcAGAGUGUUcAGTsT 33% 2% 48% 11% ND8391 213 cuAuAAcAucuGcuGGAGuTsT 214 ACUCcAGcAGAUGUuAuAGTsT 16% 1% 17% 4% ND8392 215 GcAccAuAcuuucuuGuAcTsT 216 GuAcAAGAAAGuAUGGUGCTsT 19% 1% 22% 4% ND8393 217 uGucuAGcccAucAuccuGTsT 128 cAGGAUGAUGGGCuAGAcATsT 69% 3% 92% 15% ND8394 219 AGGAcccuAGAccucuGcATsT 220 UGcAGAGGUCuAGGGUCCUTsT 94% 5% 86% 13% ND8395 221 ccAccGcuccuAccGAGAGTsT 222 CUCUCGGuAGGAGCGGUGGTsT 55% 1% 65% 6% ND8396 223 uAccGAGAGcucuucGAGuTsT 224 ACUCGAAGAGCUCUCGGuATsT 11% 1% 11% 1% ND8397 225 AAcAuccuGucGAGGcuGcTsT 226 GcAGCCUCGAcAGGAUGUUTsT 90% 7% 72% 11% ND8398 227 GAAccuuuAcccuucAAAGTsT 228 CUUUGAAGGGuAAAGGUUCTsT 22% 2% 25% 4% ND8399 229 GGuuccGAAGccGAuAcuGTsT 230 cAGuAUCGGCUUCGGAACCTsT 93% 9% 89% 9% ND8400 231 AAGccGAuAcuGGucuccATsT 232 UGGAGACcAGuAUCGGCUUTsT 35% 2% 42% 9% ND8401 233 ucuAGcccAuCAuccuGcuTsT 234 AGcAGGAUGAUGGGCuAGATsT 95% 8% 95% 14% ND8402 235 cGGcGccAuccGccuGGuGTsT 236 cACcAGGCGGAUGGCGCCGTsT 81% 8% 89% 17% ND8403 237 uuuucGGAGAGuAcuucAGTsT 238 CUGAAGuACUCUCCGAAAATsT 13% 1% 13% 1% ND8404 239 GAGAGuAcuucAGcuAcccTsT 240 GGGuAGCUGAAGuACUCUCTsT 71% 3% 100% 10% ND8405 241 GAcGcucuuuGAccuGuAcTsT 242 GuAcAGGUcAAAGAGCGUCTsT 84% 5% 92% 13% ND8406 243 uGuGuAuucAcuccuGcuuTsT 244 AAGcAGGAGUGAAuAcAcATsT 78% 2% 89% 8% ND8407 245 AAcAAcAAGAGAAAuGGAGTsT 246 CUCcAUUUCUCUUGUUGUUTsT 66% 3% 88% 21% ND8408 247 AuuGAAGGAuGuGcAGGGcTsT 248 GCCCUGcAcAUCCUUcAAUTsT 25% 1% 36% 6% ND8409 249 ucucAGAGccGcccAAAcuTsT 250 AGUUUGGGCGGCUCUGAGATsT 18% 1% 24% 2% ND8410 251 AAAcAcAAccAAGGGuAcATsT 252 UGuACCCUUGGUUGUGUUUTsT 21% 1% 35% 2% ND8411 253 uAcccGuGcccucAcAGAGTsT 254 CUCUGUGAGGGcACGGGuATsT 57% 2% 67% 4% ND8412 255 uAGcAcAcuAuAAcAucuGTsT 256 cAGAUGUuAuAGUGUGCuATsT 30% 2% 41% 1% ND8413 257 GGuGuGuAuucAcuccuGcTsT 258 GcAGGAGUGAAuAcAcACCTsT 73% 1% 90% 9% ND8414 259 cAUGAuCAAGGAGuGuGGcTsT 260 GCcAcACUCCUUGAUcAUGTsT 65% 2% 67% 5% ND8415 261 AcucAcGAuGGcccucGGuTsT 262 ACCGAGGGCcAUCGUGAGUTsT 96% 6% 95% 6% ND8416 263 GGAGCuuuGAcAAGGAAcuTsT 264 AGUUCCUUGUcAAAGCUCCTsT 24% 1% 28% 4% ND8417 265 AuAcccGuGcccucAcAGATsT 266 UCUGUGAGGGcACGGGuAUTsT 54% 1% 62% 2% ND8418 267 GGAGuGGccAAAGucAAcATsT 268 UGUUGACUUUGGCcACUCCTsT 93% 2% 86% 11% ND8419 269 AAcuAcAAAAccAAuucuGTsT 270 cAGAAUUGGUUUUGuAGUUTsT 101% 5% 108% 19% ND8420 271 uGcuGGAGuGuuGcuGuuGTsT 272 cAAcAGcAAcACUCcAGcATsT 29% 1% 26% 1% ND8421 273 AGGucuccuGcAAccAGGcTsT 274 GCCUGGUUGcAGGAGACCUTsT 95% 10% 91% 17% ND8422 275 cuuuGGcAuGAuGuAcuGGTsT 276 CcAGuAcAUcAUGCcAAAGTsT 86% 3% 84% 6% ND8423 277 cAucuGcAcccucAAucccTsT 278 GGGAUUGAGGGUGcAGAUGTsT 82% 11% 73% 4% ND8424 279 cGAcUGcAccAAGAAuGGcTsT 280 GCcAUUCUUGGUGcAGUCGTsT 70% 8% 69% 7% ND8425 281 AAAAcAcAAccAAGGGuAcTsT 282 GuACCCUUGGUUGUGUUUUTsT 95% 6% 106% 12% ND8426 283 cAucuGcuGGAGuGuuGcuTsT 284 AGcAAcACUCcAGcAGAUGTsT 30% 2% 37% 1% ND8427 285 ccuAcAucuucuAuccGcGTsT 286 CGCGGAuAGAAGAUGuAGGTsT 42% 6% 30% 1% ND8428 287 GccuAcAUcuucuAuccGcTsT 288 GCGGAUAGAAGAUGUAGGCTsT 65% 7% 54% 3% ND8429 289 GAGuGGuAccGcuuccAcuTsT 290 AGUGGAAGCGGuACcACUCTsT 95% 11% 86% 19% ND8430 291 GGuAccGcuuccAcuAcAuTsT 292 AUGuAGUGGAAGCGGuACCTsT 111% 19% 96% 14% ND8431 293 GuGGuAccGcuuccAcuAcTsT 294 GuAGUGGAAGCGGuACcACTsT 98% 13% 52% 26% ND8432 295 GAAuuAcucucAcuuccAcTsT 296 GUGGAAGUGAGAGuAAUUCTsT 111% 21% 73% 27% ND8433 297 AAuuAcucucAcuuccAccTsT 298 GGUGGAAGUGAGAGuAAUUTsT 109% 22% 105% 7% ND8434 299 uAcucucAcuuccAccAccTsT 300 GGUGGUGGAAGUGAGAGuATsT 106% 23% 95% 7% ND8435 301 AGuGGuAccGcuuccAcuATsT 302 uAGUGGAAGCGGuACcACUTsT 109% 18% 102% 9% ND8436 303 GGGcAAcuucAucuucGccTsT 304 GGCGAAGAUGAAGUUGCCCTsT 109% 18% 107% 14% ND-8501 305 AGCCCGUAGCGUGGCCUCCTsT 306 GGAGGCCACGCUACGGGCUTsT 84% 14% 69% 3% ND-8502 307 CCGGGUAAUGGUGCACGGGTsT 308 CCCGUGCACCAUUACCCGGTsT 41% 6% 30% 2% ND-8503 309 AUGCUAUCGCGACAGAACATsT 310 UGUUCUGUCGCGAUAGCAUTsT 11% 2% 10% 2% ND-8504 311 UGCUAUCGCGACAGAACAATsT 312 UUGUUCUGUCGCGAUAGCATsT 15% 2% 10% 0% ND-8505 313 GCCCGUUUAUGUAUGCUCCTsT 314 GGAGCAUACAUAAACGGGCTsT 23% 3% 16% 1% ND-8506 315 GCCCGUAGCGUGGCCUCCATsT 316 UGGAGGCCACGCUACGGGCTsT 32% 3% 22% 1% ND-8507 317 CCGGAAAUUAAAGAGGAGCTsT 318 GCUCCUCUUUAAUUUCCGGTsT 35% 4% 24% 1% ND-8508 319 CCGAAGGUUCCGAAGCCGATsT 320 UCGGCUUCGGAACCUUCGGTsT 19% 2% 13% 1% ND-8509 321 GCAAUUCGGCCUGCUUUUCTsT 322 GAAAAGCAGGCCGAAUUGCTsT 12% 1% 8% 1% ND-8510 323 GGCGAAUUACUCUCACUUCTsT 324 GAAGUGAGAGUAAUUCGCCTsT 21% 2% 18% 1% ND-8511 325 GCGAAUUACUCUCACUUCCTsT 326 GGAAGUGAGAGUAAUUCGCTsT 12% 2% 8% 1% ND-8512 327 AACCAGGCGAAUUACUCUCTsT 328 GAGAGUAAUUCGCCUGGUUTsT 99% 11% 79% 5% ND-8513 329 GGUAAUGGUGCACGGGCAGTsT 330 CUGCCCGUGCACCAUUACCTsT 61% 6% 42% 4% ND-8514 331 CUCACGAUGGCCCUCGGUGTsT 332 CACCGAGGGCCAUCGUGAGTsT 94% 11% 70% 4% ND-8515 333 GCUCCGAAGGUUCCGAAGCTsT 334 GCUUCGGAACCUUCGGAGCTsT 18% 2% 17% 2% ND-8516 335 GCCGAUACUGGUCUCCAGGTsT 336 CCUGGAGACCAGUAUCGGCTsT 14% 1% 12% 1% ND-8517 337 CCGAUACUGGUCUCCAGGCTsT 338 GCCUGGAGACCAGUAUCGGTsT 42% 5% 33% 2% ND-8518 339 UGCUGUUGCACCAUACUUUTsT 340 AAAGUAUGGUGCAACAGCATsT 10% 1% 9% 0% ND-8519 341 AACGGUCUGUCCCUGAUGCTsT 342 GCAUCAGGGACAGACCGTTTsT 60% 7% 52% 8% ND-8520 343 UUAACUUGCGGCCUGGCGUTsT 344 ACGCCAGGCCGCAAGUUAATsT 82% 25% 77% 18% ND-8521 345 GCUGGUUACUCACGAUGGCTsT 346 GCCAUCGUGAGUAACCAGCTsT 36% 4% 34% 7% ND-8522 347 UUACUCACGAUGGCCCUCGTsT 348 CGAGGGCCAUCGUGAGUAATsT 105% 21% 113% 21% ND-8523 349 GAAGCCGAUACUGGUCUCCTsT 350 GGAGACCAGUAUCGGCUUCTsT 24% 2% 18% 2% ND-8524 351 GAUACUGGUCUCCAGGCCGTsT 352 CGGCCUGGAGACCAGUAUCTsT 30% 5% 25% 3% ND-8525 353 AUACUGGUCUCCAGGCCGATsT 354 UCGGCCUGGAGACCAGUAUTsT 12% 1% 11% 2% ND-8526 355 CAACGGUCUGUCCCUGAUGTsT 356 CAUCAGGGACAGACCGUUGTsT 24% 7% 24% 2% ND-8527 357 UUUAACUUGCGGCCUGGCGTsT 358 CGCCAGGCCGCAAGUUAAATsT 122% 6% 107% 9% ND-8528 359 UACUCACGAUGGCCCUCGGTsT 360 CCGAGGGCCAUCGUGAGUATsT 78% 6% 84% 7% ND-8529 361 UUUCGGAGAGUACUUCAGCTsT 362 GCUGAAGUACUCUCCGAAATsT 87% 18% 80% 17% ND-8530 363 GCAGACGCUCUUUGACCUGTsT 364 CAGGUCAAAGAGCGUCUGCTsT 14% 2% 13% 0% ND-8531 365 CUACAUCUUCUAUCCGCGGTsT 366 CCGCGGAUAGAAGAUGUAGTsT 20% 4% 18% 3% ND-8532 357 AGGCGAAUUACUCUCACUUTsT 368 AAGUGAGAGUAAUUCGCCUTsT 25% 5% 18% 1% ND-8533 359 CCGCUUCAACCAGGUCUCCTsT 370 GGAGACCUGGUUGAAGCGGTsT 30% 11% 22% 2% ND-8534 371 CAACCGCAUGAAGACGGCCTsT 372 GGCCGUCUUCAUGCGGUUGTsT 33% 4% 23% 1% ND-8535 373 AUGAAGACGGCCUUCUGGGTsT 374 CCCAGAAGGCCGUCUUCAUTsT 114% 12% 84% 15% ND-8536 375 AGCACAACCGCAUGAAGACTsT 376 GUCUUCAUGCGGUUGUGCUTsT 118% 1% 16% 3% ND-8537 377 UCGAGUUCCACCGCUCCUATsT 378 UAGGAGCGGUGGAACUCGATsT 25% 0% 26% 3% ND-8538 379 CUGCUUCUACCAGACAUACTsT 380 GUAUGUCUGGUAGAAGCAGTsT 12% 1% 13% 2% ND-8539 381 GAGGGAGUGGUACCGCUUCTsT 382 GAAGCGGUACCACUCCCUCTsT 43% 1% 47% 14% ND-8540 383 CCUUUAUGGAUGAUGGUGGTsT 384 CCACCAUCAUCCAUAAAGGTsT 61% 5% 60% 8% ND-8541 385 UGAGGGAGUGGUACCGCUUTsT 386 AAGCGGUACCACUCCCUCATsT 36% 5% 35% 5% ND-8542 387 CCUGCAACCAGGCGAAUUATsT 388 UAAUUCGCCUGGUUGCAGGTsT 19% 2% 16% 1% ND-8543 389 GGCCUGGCGUGGAGACCUCTsT 390 GAGGUCUCCACGCCAGGCCTsT 28% 7% 20% 2% ND-8544 391 UGCUUUUCGGAGAGUACUUTsT 392 AAGUACUCUCCGAAAAGCATsT 22% 5% 17% 1% ND-8545 393 CCCGUAGCGUGGCCUCCAGTsT 394 CUGGAGGCCACGCUACGGGTsT 25% 3% 22% 2% ND-8546 395 CCGUAGCGUGGCCUCCAGCTsT 396 GCUGGAGGCCACGCUACGGTsT 62% 5% 57% 9% ND-8547 397 CCAGGCGAAUUACUCUCACTsT 398 GUGAGAGUAAUUCGCCUGGTsT 23% 11% 16% 2% ND-8548 399 GAAACUGCUAUACUUUCAATsT 400 UUGAAAGUAUAGCAGUUUCTsT 9% 3% 3% 0% ND-8549 401 GCCCGGGUAAUGGUGCACGTsT 402 CGUGCACCAUUACCCGGGCTsT 87% 9% 92% 14% ND-8550 403 CCCGGGUAAUGGUGCACGGTsT 404 CCGUGCACCAUUACCCGGGTsT 19% 12% 14% 1% ND-8551 405 CGGGUAAUGGUGCACGGGCTsT 406 GCCCGUGCACCAUUACCCGTsT 68% 11% 73% 3% ND-8552 407 GGGUAAUGGUGCACGGGCATsT 408 UGCCCGUGCACCAUUACCCTsT 30% 6% 33% 2% ND-8553 409 UAAUGGUGCACGGGCAGGATsT 410 UCCUGCCCGUGCACCAUUATsT 29% 3% 31% 1% ND-8554 411 CUGGUUACUCACGAUGGCCTsT 412 GGCCAUCGUGAGUAACCAGTsT 74% 16% 66% 8% ND-8555 413 GUUACUCACGAUGGCCCUCTsT 414 GAGGGCCAUCGUGAGUAACTsT 91% 21% 88% 10% ND-8556 415 UGUCACGAUGGUCACCCUCTsT 416 GAGGGUGACCAUCGUGACATsT 72% 4% 76% 12% ND-8557 417 UGCUCCGAAGGUUCCGAAGTsT 418 CUUCGGAACCUUCGGAGCATsT 51% 2% 59% 18% ND-8558 419 UCCGAAGGUUCCGAAGCCGTsT 420 CGGCUUCGGAACCUUCGGATsT 109% 11% 77% 13% ND-8559 421 UUCCGAAGCCGAUACUGGUTsT 422 ACCAGUAUCGGCUUCGGAATsT 46% 20% 33% 6% ND-8560 423 AGCCGAUACUGGUCUCCAGTsT 424 CUGGAGACCAGUAUCGGCUTsT 15% 6% 10% 1% ND-8561 425 CUUGGUACUGCCUCUGAACTsT 426 GUUCAGAGGCAGUACCAAGTsT 16% 3% 12% 3% ND-8562 427 CUCCCGUAGCACACUAUAATsT 428 UUAUAGUGUGCUACGGGAGTsT 14% 6% 10% 1% ND-8563 429 UCCCGUAGCACACUAUAACTsT 430 GUUAUAGUGUGCUACGGGATsT 43% 11% 36% 4% ND-8564 431 UGCACCAUACUUUCUUGUATsT 432 UACAAGAAAGUAUGGUGCATsT 17% 6% 13% 3% ND-8565 433 UUGCCCGUUUAUGUAUGCUTsT 434 AGCAUACAUAAACGGGCAATsT 84% 2% 103% 12% ND-8566 435 UGCCCGUUUAUGUAUGCUCTsT 436 GAGCAUACAUAAACGGGCATsT 69% 25% 93% 4% ND-8567 437 GGACCCUAGACCUCUGCAGTsT 438 CUGCAGAGGUCUAGGGUCCTsT 29% 8% 33% 2% ND-8568 439 CCUAGACCUCUGCAGCCCATsT 440 UGGGCUGCAGAGGUCUAGGTsT 18% 2% 19% 1% ND-8569 441 UGGCAUGAUGUACUGGCAATsT 442 UUGCCAGUACAUCAUGCCATsT 19% 3% 20% 5% ND-8570 443 UACUGGCAAUUCGGCCUGCTsT 444 GCAGGCCGAAUUGCCAGUATsT 86% 15% 83% 16% ND-8571 445 AAUUCGGCCUGCUUUUCGGTsT 446 CCGAAAAGCAGGCCGAAUUTsT 19% 3% 24% 4% ND-8572 447 CUGCUUUUCGGAGAGUACUTsT 448 AGUACUCUCCGAAAAGCAGTsT 8% 2% 12% 2% ND-8573 449 UUCGGAGAGUACUUCAGCUTsT 450 AGCUGAAGUACUCUCCGAATsT 27% 3% 40% 5% ND-8574 451 AGCAGACGCUCUUUGACCUTsT 452 AGGUCAAAGAGCGUCUGCUTsT 15% 0% 19% 4% ND-8575 453 CUUGCAGCGCCUGAGGGUCTsT 454 GACCCUCAGGCGCUGCAAGTsT 35% 1% 40% 4% ND-8576 455 UGGCUUUAACUUGCGGCCUTsT 456 AGGCCGCAAGUUAAAGCCATsT 47% 3% 53% 8% ND-8577 457 GCUUUAACUUGCGGCCUGGTsT 458 CCAGGCCGCAAGUUAAAGCTsT 20% 2% 25% 5% ND-8578 459 UAACUUGCGGCCUGGCGUGTsT 460 CACGCCAGGCCGCAAGUUATsT 75% 7% 82% 4% ND-8579 461 ACCUUUACCCUUCAAAGUATsT 462 UACUUUGAAGGGUAAAGGUTsT 14% 2% 17% 3% ND-8580 463 GGUUACUCACGAUGGCCCUTsT 464 AGGGCCAUCGUGAGUAACCTsT 63% 5% 70% 11% ND-8581 465 CACGAUGGCCCUCGGUGACTsT 466 GUCACCGAGGGCCAUCGUGTsT 59% 2% 50% 5% ND-8582 467 AGAUGCUAUCGCGACAGAATsT 468 UUCUGUCGCGAUAGCAUCUTsT 18% 1% 18% 1% ND-8583 469 ACGAUGGUCACCCUCCUGUTsT 470 ACAGGAGGGUGACCAUCGUTsT 48% 3% 52% 6% ND-8584 471 CUCCGAAGGUUCCGAAGCCTsT 472 GGCUUCGGAACCUUCGGAGTsT 18% 2% 20% 5% ND-8585 473 AAGGUUCCGAAGCCGAUACTsT 474 GUAUCGGCUUCGGAACCUUTsT 26% 2% 28% 1% ND-8586 475 GGUACUGCCUCUGAACACUTsT 476 AGUGUUCAGAGGCAGUACCTsT 12% 1% 12% 1% ND-8587 477 AGCUUUGACAAGGAACUUUTsT 478 AAAGUUCCUUGUCAAAGCUTsT 17% 2% 18% 2% ND-8588 479 UUUGACAAGGAACUUUCCUTsT 480 AGGAAAGUUCCUUGUCAAATsT 78% 5% 73% 2% ND-8589 481 UGACAAGGAACUUUCCUAATsT 482 UUAGGAAAGUUCCUUGUCATsT 14% 1% 16% 1% ND-8590 483 CCCGUAGCACACUAUAACATsT 484 UGUUAUAGUGUGCUACGGGTsT 9% 1% 11% 2% ND-8591 485 CACUAUAACAUCUGCUGGATsT 486 UCCAGCAGAUGUUAUAGUGTsT 18% 2% 20% 2% ND-8592 487 UUGCUGUUGCACCAUACUUTsT 488 AAGUAUGGUGCAACAGCAATsT 23% 2% 25% 8% ND-8593 489 GUACUGGCAAUUCGGCCUGTsT 490 CAGGCCGAAUUGCCAGUACTsT 66% 3% 62% 4% ND-8594 491 UUCGGCCUGCUUUUCGGAGTsT 492 CUCCGAAAAGCAGGCCGAATsT 97% 7% 86% 8% ND-8595 493 CCUGCUUUUCGGAGAGUACTsT 494 GUACUCUCCGAAAAGCAGGTsT 11% 2% 14% 3% ND-8596 495 GCUUUUCGGAGAGUACUUCTsT 496 GAAGUACUCUCCGAAAAGCTsT 12% 1% 17% 2% ND-8597 497 CUUUUCGGAGAGUACUUCATsT 498 UGAAGUACUCUCCGAAAAGTsT 11% 1% 14% 2% ND-8598 499 CAACCUCAACUCGGACAAGTsT 500 CUUGUCCGAGUUGAGGUUGTsT 15% 2% 16% 2% ND-8599 501 CUACCAGACAUACUCAUCATsT 502 UGAUGAGUAUGUCUGGUAGTsT 17% 1% 18% 2% ND-8600 503 CUGUCGAGGCUGCCAGAGATsT 504 UCUCUGGCAGCCUCGACAGTsT 17% 0% 16% 1% ND-8601 505 AAACUGCUAUACUUUCAAUTsT 506 AUUGAAAGUAUAGCAGUUUTsT 28% 1% 26% 1% ND-8602 507 GGCUUUAACUUGCGGCCUGTsT 508 CAGGCCGCAAGUUAAAGCCTsT 21% 2% 18% 1% ND-8603 509 CUUUAACUUGCGGCCUGGCTsT 510 GCCAGGCCGCAAGUUAAAGTsT 81% 2% 69% 6% ND-8604 511 AGGUGUGUAUUCACUCCUGTsT 512 CAGGAGUGAAUACACACCUTsT 47% 4% 40% 1% ND-8605 513 ACGAUGGCCCUCGGUGACATsT 514 UGUCACCGAGGGCCAUCGUTsT 40% 6% 35% 2% ND-8606 515 CUGAACACUCUGGUUUCCCTsT 516 GGGAAACCAGAGUGUUCAGTsT 60% 2% 75% 4% ND-8607 517 CUAUAACAUCUGCUGGAGUTsT 518 ACUCCAGCAGAUGUUAUAGTsT 17% 1% 24% 3% ND-8608 519 GCACCAUACUUUCUUGUACTsT 520 GUACAAGAAAGUAUGGUGCTsT 10% 1% 15% 3% ND-8609 521 UGUCUAGCCCAUCAUCCUGTsT 522 CAGGAUGAUGGGCUAGACATsT 62% 2% 75% 12% ND-8610 523 AGGACCCUAGACCUCUGCATsT 524 UGCAGAGGUCUAGGGUCCUTsT 61% 5% 73% 10% ND-8611 525 CCACCGCUCCUACCGAGAGTsT 526 CUCUCGGUAGGAGCGGUGGTsT 21% 2% 29% 5% ND-8612 527 UACCGAGAGCUCUUCGAGUTsT 528 ACUCGAAGAGCUCUCGGUATsT 13% 1% 22% 3% ND-8613 529 AACAUCCUGUCGAGGCUGCTsT 530 GCAGCCUCGACAGGAUGUUTsT 57% 2% 70% 4% ND-8614 531 GAACCUUUACCCUUCAAAGTsT 532 CUUUGAAGGGUAAAGGUUCTsT 13% 3% 16% 2% ND-8615 533 GGUUCCGAAGCCGAUACUGTsT 534 CAGUAUCGGCUUCGGAACCTsT 18% 1% 24% 2% ND-8616 535 AAGCCGAUACUGGUCUCCATsT 536 UGGAGACCAGUAUCGGCUUTsT 19% 1% 25% 2% ND-8617 537 UCUAGCCCAUCAUCCUGCUTsT 538 AGCAGGAUGAUGGGCUAGATsT 93% 3% 101% 3% ND-8618 539 CGGCGCCAUCCGCCUGGUGTsT 540 CACCAGGCGGAUGGCGCCGTsT 85% 4% 99% 4% ND-8619 541 UUUUCGGAGAGUACUUCAGTsT 542 CUGAAGUACUCUCCGAAAATsT 63% 2% 77% 3% ND-8620 543 GAGAGUACUUCAGCUACCCTsT 544 GGGUAGCUGAAGUACUCUCTsT 26% 1% 30% 4% ND-8621 545 GACGCUCUUUGACCUGUACTsT 546 GUACAGGUCAAAGAGCGUCTsT 17% 2% 19% 3% ND-8622 547 UGUGUAUUCACUCCUGCUUTsT 548 AAGCAGGAGUGAAUACACATsT 49% 3% 58% 11% ND-8623 549 AACAACAAGAGAAAUGGAGTsT 550 CUCCAUUUCUCUUGUUGUUTsT 74% 7% 70% 4% ND-8624 551 AUUGAAGGAUGUGCAGGGCTsT 552 GCCCUGCACAUCCUUCAAUTsT 85% 6% 87% 12% ND-8625 553 UCUCAGAGCCGCCCAAACUTsT 554 AGUUUGGGCGGCUCUGAGATsT 53% 3% 51% 6% ND-8626 555 AAACACAACCAAGGGUACATsT 556 UGUACCCUUGGUUGUGUUUTsT 17% 2% 18% 2% ND-8627 557 UACCCGUGCCCUCACAGAGTsT 558 CUCUGUGAGGGCACGGGUATsT 58% 3% 55% 3% ND-8628 559 UAGCACACUAUAACAUCUGTsT 560 CAGAUGUUAUAGUGUGCUATsT 64% 3% 64% 15% ND-8629 561 GGUGUGUAUUCACUCCUGCTsT 562 GCAGGAGUGAAUACACACCTsT 25% 3% 23% 2% ND-8630 563 CAUGAUCAAGGAGUGUGGCTsT 564 GCCACACUCCUUGAUCAUGTsT 32% 2% 28% 2% ND-8631 565 ACUCACGAUGGCCCUCGGUTsT 566 ACCGAGGGCCAUCGUGAGUTsT 96% 1% 88% 4% ND-8632 567 GGAGCUUUGACAAGGAACUTsT 568 AGUUCCUUGUCAAAGCUCCTsT 14% 1% 14% 2% ND-8633 569 AUACCCGUGCCCUCACAGATsT 570 UCUGUGAGGGCACGGGUAUTsT 21% 2% 16% 1% ND-8634 571 GGAGUGGCCAAAGUCAACATsT 572 UGUUGACUUUGGCCACUCCTsT 21% 3% 16% 1% ND-8635 573 AACUACAAAACCAAUUCUGTsT 574 CAGAAUUGGUUUUGUAGUUTsT 49% 5% 37% 3% ND-8636 575 UGCUGGAGUGUUGCUGUUGTsT 576 CAACAGCAACACUCCAGCATsT 27% 3% 21% 2% ND-8637 577 AGGUCUCCUGCAACCAGGCTsT 578 GCCUGGUUGCAGGAGACCUTsT 62% 8% 61% 4% ND-8638 579 CUUUGGCAUGAUGUACUGGTsT 580 CCAGUACAUCAUGCCAAAGTsT 66% 6% 52% 8% ND-8639 581 CAUCUGCACCCUCAAUCCCTsT 582 GGGAUUGAGGGUGCAGAUGTsT 50% 7% 40% 4% ND-8640 583 CGACUGCACCAAGAAUGGCTsT 584 GCCAUUCUUGGUGCAGUCGTsT 67% 6% 54% 5% ND-8641 585 AAAACACAACCAAGGGUACTsT 586 GUACCCUUGGUUGUGUUUUTsT 14% 2% 14% 1% ND-8642 587 CAUCUGCUGGAGUGUUGCUTsT 588 AGCAACACUCCAGCAGAUGTsT 13% 2% 13% 1% ND-8643 589 CCUACAUCUUCUAUCCGCGTsT 590 CGCGGAUAGAAGAUGUAGGTsT 15% 4% 13% 0% ND-8644 591 GCCUACAUCUUCUAUCCGCTsT 592 GCGGAUAGAAGAUGUAGGCTsT 14% 3% 11% 1% ND-8645 593 GAGUGGUACCGCUUCCACUTsT 594 AGUGGAAGCGGUACCACUCTsT 16% 0% 20% 1% ND-8646 595 GGUACCGCUUCCACUACAUTsT 596 AUGUAGUGGAAGCGGUACCTsT 12% 0% 14% 1% ND-8647 597 GUGGUACCGCUUCCACUACTsT 598 GUAGUGGAAGCGGUACCACTsT 42% 4% 44% 3% ND-8648 599 GAAUUACUCUCACUUCCACTsT 600 GUGGAAGUGAGAGUAAUUCTsT 10% 1% 11% 3% ND-8649 601 AAUUACUCUCACUUCCACCTsT 602 GGUGGAAGUGAGAGUAAUUTsT 105% 10% 102% 8% ND-8650 603 UACUCUCACUUCCACCACCTsT 604 GGUGGUGGAAGUGAGAGUATsT 55% 6% 54% 8% ND-8651 605 AGUGGUACCGCUUCCACUATsT 606 UAGUGGAAGCGGUACCACUTsT 57% 6% 59% 12% ND-8652 607 GGGCAACUUCAUCUUCGCCTsT 608 GGCGAAGAUGAAGUUGCCCTsT 47% 12% 36% 7% TABLE 1B Selected siRNAs in extended screening set (“human-only” siRNAs).", "A further 344 iRNA sequences were identified and were designed to be fully complementary to the human alpha-ENaC sequences, according to the design criteria described in the examples section.", "All siRNAs listed in this screening set were modified only with a phosphorothioate linkage at the 3′-end between nucleotides 20 and 21 of each strand.", "The percentage residual expression of alpha-ENaC in single-dose transfection assay is shown (refer to examples section for methods used).", "2nd screen 1st screen single single dose dose @ 50 Duplex Seq Seq @ 50 nM in nM in ID ID Sense ID Antissense H441; MV SD H441; MV SD ND- 609 CUGCGGCUAAGUCUCUUUUTsT 610 AAAAGAGACUUAGCCGCAGTsT 94% 8% 10445 ND- 611 AUCGCGACAGAACAAUUACTsT 612 GUAAUUGUUCUGUCGCGAUTsT 13% 2% 10446 ND- 613 UCGCGACAGAACAAUUACATsT 614 UGUAAUUGUUCUGUCGCGATsT 18% 1% 10447 ND- 615 CCCGUUUAUGUAUGCUCCATsT 616 UGGAGCAUACAUAAACGGGTsT 41% 1% 10448 ND- 617 CCCGGGUAAGUAAAGGCAGTsT 618 CUGCCUUUACUUACCCGGGTsT 23% 1% 10449 ND- 619 GGUACCCGGAAAUUAAAGATsT 620 UCUUUAAUUUCCGGGUACCTsT 14% 2% 10450 ND- 621 GCUAUCGCGACAGAACAAUTsT 622 AUUGUUCUGUCGCGAUAGCTsT 24% 2% 10451 ND- 623 UAUCGCGACAGAACAAUUATsT 624 UAAUUGUUCUGUCGCGAUATsT 12% 1% 10452 ND- 625 UGCGGCUAAGUCUCUUUUUTsT 626 AAAAAGAGACUUAGCCGCATsT 46% 3% 10453 ND- 627 GGCGAUUAUGGCGACUGCATsT 628 UGCAGUCGCCAUAAUCGCCTsT 14% 0% 10454 ND- 629 AUGUCUAGCCCAUCAUCCUTsT 630 AGGAUGAUGGGCUAGACAUTsT 12% 2% 10455 ND- 631 CUACAGGUACCCGGAAAUUTsT 632 AAUUUCCGGGUACCUGUAGTsT 28% 2% 10456 ND- 633 CCGUCGAGCCCGUAGCGUGTsT 634 CACGCUACGGGCUCGACGGTsT 27% 3% 10457 ND- 635 CGCGACAGAACAAUUACACTsT 636 GUGUAAUUGUUCUGUCGCGTsT 39% 7% 10458 ND- 637 AGGUACCCGGAAAUUAAAGTsT 638 CUUUAAUUUCCGGGUACCUTsT 30% 3% 10459 ND- 639 CAUGCACGGGUUUCCUGCCTsT 640 GGCAGGAAACCCGUGCAUGTsT 95% 6% 10460 ND- 641 AGCUUGCGGGACAACAACCTsT 642 GGUUGUUGUCCCGCAAGCUTsT 94% 8% 10461 ND- 643 ACUGCGGCUAAGUCUCUUUTsT 644 AAAGAGACUUAGCCGCAGUTsT 13% 2% 10462 ND- 645 CAUCCCUUAGAACCCUGCUTsT 646 AGCAGGGUUCUAAGGGAUGTsT 18% 1% 10463 ND- 647 ACCCGGGUAAGUAAAGGCATsT 648 UGCCUUUACUUACCCGGGUTsT 41% 1% 10464 ND- 649 GAUUAUGGCGACUGCACCATsT 650 UGGUGCAGUCGCCAUAAUCTsT 23% 1% 10465 ND- 651 CUCGGACAAGCUCGUCUUCTsT 652 GAAGACGAGCUUGUCCGAGTsT 14% 2% 10466 ND- 653 GCGAUUAUGGCGACUGCACTsT 654 GUGCAGUCGCCAUAAUCGCTsT 24% 2% 10467 ND- 655 AAUUACACCGUCAACAACATsT 656 UGUUGUUGACGGUGUAAUUTsT 12% 1% 10468 ND- 657 AACUGCCGUUGAUGUGUGGTsT 658 CCACACAUCAACGGCAGUUTsT 46% 3% 10469 ND- 659 AACUGCGGCUAAGUCUCUUTsT 660 AAGAGACUUAGCCGCAGUUTsT 14% 0% 10470 ND- 661 CCGCUGAUAACCAGGACAATsT 662 UUGUCCUGGUUAUCAGCGGTsT 12% 2% 10471 ND- 663 AAGGGUACACGCAGGCAUGTsT 664 CAUGCCUGCGUGUACCCUUTsT 28% 2% 10472 ND- 665 CCGGGUAAGUAAAGGCAGATsT 666 UCUGCCUUUACUUACCCGGTsT 27% 3% 10473 ND- 667 CCCAUACCAGGUCUCAUGGTsT 668 CCAUGAGACCUGGUAUGGGTsT 39% 7% 10474 ND- 669 AUUAUGGCGACUGCACCAATsT 670 UUGGUGCAGUCGCCAUAAUTsT 30% 3% 10475 ND- 671 AUGCACGGGUUUCCUGCCCTsT 672 GGGCAGGAAACCCGUGCAUTsT 95% 6% 10476 ND- 673 CUAGCCCUCCACAGUCCACTsT 674 GUGGACUGUGGAGGGCUAGTsT 43% 7% 10477 ND- 675 CAGGUACCCGGAAAUUAAATsT 676 UUUAAUUUCCGGGUACCUGTsT 11% 1% 10478 ND- 677 AAUACAGCUCCUUCACCACTsT 678 GUGGUGAAGGAGCUGUAUUTsT 30% 3% 10479 ND- 679 CACGGGUUUCCUGCCCAGCTsT 680 GCUGGGCAGGAAACCCGUGTsT 19% 1% 10480 ND- 681 GGACUGAAUCUUGCCCGUUTsT 682 AACGGGCAAGAUUCAGUCCTsT 14% 2% 10481 ND- 683 CGUUUAUGUAUGCUCCAUGTsT 684 CAUGGAGCAUACAUAAACGTsT 15% 1% 10482 ND- 685 GGGUACUGCUACUAUAAGCTsT 686 GCUUAUAGUAGCAGUACCCTsT 11% 0% 10483 ND- 687 UCGGUGUUGUCUGUGGUGGTsT 688 CCACCACAGACAACACCGATsT 65% 5% 10484 ND- 689 AAACUGCCGUUGAUGUGUGTsT 690 CACACAUCAACGGCAGUUUTsT 73% 6% 10485 ND- 691 GCGAAACUUGGAGCUUUGATsT 692 UCAAAGCUCCAAGUUUCGCTsT 8% 1% 10486 ND- 693 GGCCCGUCGAGCCCGUAGCTsT 694 GCUACGGGCUCGACGGGCCTsT 26% 3% 10487 ND- 695 GCGACAGAACAAUUACACCTsT 696 GGUGUAAUUGUUCUGUCGCTsT 10% 2% 10488 ND- 697 GCGACGGCUUAAGCCAGCCTsT 698 GGCUGGCUUAAGCCGUCGCTsT 50% 1% 10489 ND- 699 GACCCGGGUAAGUAAAGGCTsT 700 GCCUUUACUUACCCGGGUCTsT 74% 1% 10490 ND- 701 UUGAUCACUCCGCCUUCUCTsT 702 GAGAAGGCGGAGUGAUCAATsT 80% 7% 10491 ND- 703 UCUAGCCCUCCACAGUCCATsT 704 UGGACUGUGGAGGGCUAGATsT 69% 4% 10492 ND- 705 GUUUCACCAAGUGCCGGAATsT 706 UUCCGGCACUUGGUGAAACTsT 23% 3% 10493 ND- 707 CUCAACUCGGACAAGCUCGTsT 708 CGAGCUUGUCCGAGUUGAGTsT 45% 6% 10494 ND- 709 CAACUCGGACAAGCUCGUCTsT 710 GACGAGCUUGUCCGAGUUGTsT 23% 3% 10495 ND- 711 ACCCGGAAAUUAAAGAGGATsT 712 UCCUCUUUAAUUUCCGGGUTsT 13% 2% 10496 ND- 713 CCCGGAAAUUAAAGAGGAGTsT 714 CUCCUCUUUAAUUUCCGGGTsT 19% 1% 10497 ND- 715 CACCACUCUCGUGGCCGGCTsT 716 GCCGGCCACGAGAGUGGUGTsT 94% 11% 10498 ND- 717 CGUCGAGCCCGUAGCGUGGTsT 718 CCACGCUACGGGCUCGACGTsT 13% 1% 10499 ND- 719 GCUUGCGGGACAACAACCCTsT 720 GGGUUGUUGUCCCGCAAGCTsT 49% 2% 10500 ND- 721 GAAUCAACAACGGUCUGUCTsT 722 GACAGACCGUUGUUGAUUCTsT 18% 2% 10501 ND- 723 GGGCGAUUAUGGCGACUGCTsT 724 GCAGUCGCCAUAAUCGCCCTsT 8% 1% 10502 ND- 725 CGAUUAUGGCGACUGCACCTsT 726 GGUGCAGUCGCCAUAAUCGTsT 17% 1% 10503 ND- 727 UCUGCUGGUUACUCACGAUTsT 728 AUCGUGAGUAACCAGCAGATsT 38% 4% 10504 ND- 729 CUAUCGCGACAGAACAAUUTsT 730 AAUUGUUCUGUCGCGAUAGTsT 9% 1% 10505 ND- 731 CAAUUACACCGUCAACAACTsT 732 GUUGUUGACGGUGUAAUUGTsT 11% 1% 10506 ND- 733 ACCGUCAACAACAAGAGAATsT 734 UUCUCUUGUUGUUGACGGUTsT 9% 1% 10507 ND- 735 CUCCUCGGUGUUGUCUGUGTsT 736 CACAGACAACACCGAGGAGTsT 78% 5% 10508 ND- 737 GGAGGUAGCCUCCACCCUGTsT 738 CAGGGUGGAGGCUACCUCCTsT 18% 1% 10509 ND- 739 GGAGAGGUUUCUCACACCATsT 740 UGGUGUGAGAAACCUCUCCTsT 13% 1% 10510 ND- 741 CUGCCGUUGAUGUGUGGAGTsT 742 CUCCACACAUCAACGGCAGTsT 19% 2% 10511 ND- 743 UGCCGUUGAUGUGUGGAGGTsT 744 CCUCCACACAUCAACGGCATsT 82% 4% 10512 ND- 745 AGAUGGGUAAGGGCUCAGGTsT 746 CCUGAGCCCUUACCCAUCUTsT 24% 1% 10513 ND- 747 AGAACAGUAGCUGAUGAAGTsT 748 CUUCAUCAGCUACUGUUCUTsT 15% 0% 10514 ND- 749 GCGGCUAAGUCUCUUUUUCTsT 750 GAAAAAGAGACUUAGCCGCTsT 13% 1% 10515 ND- 751 CCUAAGAAACCGCUGAUAATsT 752 UUAUCAGCGGUUUCUUAGGTsT 6% 0% 10516 ND- 753 GAAACCGCUGAUAACCAGGTsT 754 CCUGGUUAUCAGCGGUUUCTsT 13% 0% 10517 ND- 755 AACCGCUGAUAACCAGGACTsT 756 GUCCUGGUUAUCAGCGGUUTsT 42% 2% 10518 ND- 757 ACCGCUGAUAACCAGGACATsT 758 UGUCCUGGUUAUCAGCGGUTsT 11% 1% 10519 ND- 759 CCAAGGGUACACGCAGGCATsT 760 UGCCUGCGUGUACCCUUGGTsT 19% 1% 10520 ND- 761 CAAGGGUACACGCAGGCAUTsT 762 AUGCCUGCGUGUACCCUUGTsT 12% 0% 10521 ND- 763 AGGGUACACGCAGGCAUGCTsT 764 GCAUGCCUGCGUGUACCCUTsT 23% 1% 10522 ND- 765 GUACACGCAGGCAUGCACGTsT 766 CGUGCAUGCCUGCGUGUACTsT 27% 1% 10523 ND- 767 AGGCAUGCACGGGUUUCCUTsT 768 AGGAAACCCGUGCAUGCCUTsT 14% 0% 10524 ND- 769 GGCAUGCACGGGUUUCCUGTsT 770 CAGGAAACCCGUGCAUGCCTsT 18% 3% 10525 ND- 771 ACGGGUUUCCUGCCCAGCGTsT 772 CGCUGGGCAGGAAACCCGUTsT 30% 1% 10526 ND- 773 GAGCAGACCCGGGUAAGUATsT 774 UACUUACCCGGGUCUGCUCTsT 24% 2% 10527 ND- 775 AGCAGACCCGGGUAAGUAATsT 775 UUACUUACCCGGGUCUGCUTsT 24% 2% 10528 ND- 777 GGGUAAGUAAAGGCAGACCTsT 778 GGUCUGCCUUUACUUACCCTsT 39% 3% 10529 ND- 779 AGCCUCAUACCCGUGCCCUTsT 780 AGGGCACGGGUAUGAGGCUTsT 82% 5% 10530 ND- 781 GUGAACGCUUCUGCCACAUTsT 782 AUGUGGCAGAAGCGUUCACTsT 13% 1% 10531 ND- 783 AAAUUGAUCACUCCGCCUUTsT 784 AAGGCGGAGUGAUCAAUUUTsT 18% 2% 10532 ND- 785 AAUUGAUCACUCCGCCUUCTsT 786 GAAGGCGGAGUGAUCAAUUTsT 19% 0% 10533 ND- 787 GCCUUGCGGUCAGGGACUGTsT 788 CAGUCCCUGACCGCAAGGCTsT 12% 1% 10534 ND- 789 CUUGCGGUCAGGGACUGAATsT 790 UUCAGUCCCUGACCGCAAGTsT 11% 0% 10535 ND- 791 UUGCGGUCAGGGACUGAAUTsT 792 AUUCAGUCCCUGACCGCAATsT 12% 0% 10536 ND- 793 AUGUAUGCUCCAUGUCUAGTsT 794 CUAGACAUGGAGCAUACAUTsT 21% 1% 10537 ND- 795 AGCAAGUAGGCAGGAGCUCTsT 796 GAGCUCCUGCCUACUUGCUTsT 19% 1% 10538 ND- 797 CAGCCCAUACCAGGUCUCATsT 798 UGAGACCUGGUAUGGGCUGTsT 27% 2% 10539 ND- 799 CAGCCGUCGCGACCUGCGGTsT 800 CCGCAGGUCGCGACGGCUGTsT 44% 4% 10540 ND- 801 GGGCCCGUCGAGCCCGUAGTsT 802 CUACGGGCUCGACGGGCCCTsT 71% 6% 10541 ND- 803 CGUAGCGUGGCCUCCAGCUTsT 804 AGCUGGAGGCCACGCUACGTsT 84% 9% 10542 ND- 805 GGUGAGGGAGUGGUACCGCTsT 806 GCGGUACCACUCCCUCACCTsT 108% 8% 10543 ND- 807 AAAGUACACACAGCAGGUGTsT 808 CACCUGCUGUGUGUACUUUTsT 140% 7% 10544 ND- 809 CCAGGUUGACUUCUCCUCATsT 810 UGAGGAGAAGUCAACCUGGTsT 18% 2% 10545 ND- 811 UGUUUCACCAAGUGCCGGATsT 812 UCCGGCACUUGGUGAAACATsT 31% 2% 10546 ND- 813 UGCUGGUUACUCACGAUGGTsT 814 CCAUCGUGAGUAACCAGCATsT 144% 10% 10547 ND- 815 UCCUCGGUGUUGUCUGUGGTsT 816 CCACAGACAACACCGAGGATsT 106% 14% 10548 ND- 817 AGGUAGCCUCCACCCUGGCTsT 818 GCCAGGGUGGAGGCUACCUTsT 74% 15% 10549 ND- 819 GCCGUUGAUGUGUGGAGGGTsT 820 CCCUCCACACAUCAACGGCTsT 26% 4% 10550 ND- 821 GAUGGGUAAGGGCUCAGGATsT 822 UCCUGAGCCCUUACCCAUCTsT 22% 1% 10551 ND- 823 CCCAACUGCGGCUAAGUCUTsT 824 AGACUUAGCCGCAGUUGGGTsT 18% 2% 10552 ND- 825 CCAAGCGAAACUUGGAGCUTsT 826 AGCUCCAAGUUUCGCUUGGTsT 16% 1% 10553 ND- 827 GGGUACACGCAGGCAUGCATsT 828 UGCAUGCCUGCGUGUACCCTsT 19% 2% 10554 ND- 829 UGCACGGGUUUCCUGCCCATsT 830 UGGGCAGGAAACCCGUGCATsT 28% 2% 10555 ND- 831 CUCCUCUAGCCUCAUACCCTsT 832 GGGUAUGAGGCUAGAGGAGTsT 109% 8% 10556 ND- 833 UCCUCUAGCCUCAUACCCGTsT 834 CGGGUAUGAGGCUAGAGGATsT 117% 7% 10557 ND- 835 UCUAGCCUCAUACCCGUGCTsT 836 GCACGGGUAUGAGGCUAGATsT 128% 9% 10558 ND- 837 UUCAUACCUCUACAUGUCUTsT 838 AGACAUGUAGAGGUAUGAATsT 52% 4% 10559 ND- 839 UCUACAUGUCUGCUUGAGATsT 840 UCUCAAGCAGACAUGUAGATsT 15% 2% 10560 ND- 841 AUAUUUCCUCAGCCUGAAATsT 842 UUUCAGGCUGAGGAAAUAUTsT 15% 2% 10561 ND- 843 AACUCCUAUGCAUCCCUUATsT 844 UAAGGGAUGCAUAGGAGUUTsT 14% 1% 10562 ND- 845 GCAUCCCUUAGAACCCUGCTsT 846 GCAGGGUUCUAAGGGAUGCTsT 20% 1% 10563 ND- 847 UGAUCACUCCGCCUUCUCCTsT 848 GGAGAAGGCGGAGUGAUCATsT 67% 7% 10564 ND- 849 UGUAAGUGCCUUGCGGUCATsT 850 UGACCGCAAGGCACUUACATsT 17% 2% 10565 ND- 851 CCUUGCGGUCAGGGACUGATsT 852 UCAGUCCCUGACCGCAAGGTsT 14% 1% 10566 ND- 853 AAUCUUGCCCGUUUAUGUATsT 854 UACAUAAACGGGCAAGAUUTsT 13% 2% 10567 ND- 855 CCGUUUAUGUAUGCUCCAUTsT 856 AUGGAGCAUACAUAAACGGTsT 19% 6% 10568 ND- 857 UGUAUGCUCCAUGUCUAGCTsT 858 GCUAGACAUGGAGCAUACATsT 87% 13% 10569 ND- 859 CAUGUCUAGCCCAUCAUCCTsT 860 GGAUGAUGGGCUAGACAUGTsT 33% 4% 10570 ND- 861 AGUAGGCAGGAGCUCAAUATsT 862 UAUUGAGCUCCUGCCUACUTsT 11% 1% 10571 ND- 863 CCUACAGGUACCCGGAAAUTsT 864 AUUUCCGGGUACCUGUAGGTsT 22% 3% 10572 ND- 865 CCCGUCGAGCCCGUAGCGUTsT 866 ACGCUACGGGCUCGACGGGTsT 23% 1% 10573 ND- 867 GCGGUGAGGGAGUGGUACCTsT 868 GGUACCACUCCCUCACCGCTsT 30% 1% 10574 ND- 869 UUAUGGCGACUGCACCAAGTsT 870 CUUGGUGCAGUCGCCAUAATsT 77% 6% 10575 ND- 871 CUAUAAGCUCCAGGUUGACTsT 872 GUCAACCUGGAGCUUAUAGTsT 11% 1% 10576 ND- 873 UAUAAGCUCCAGGUUGACUTsT 874 AGUCAACCUGGAGCUUAUATsT 42% 8% 10577 ND- 875 AGGUUGACUUCUCCUCAGATsT 876 UCUGAGGAGAAGUCAACCUTsT 13% 3% 10578 ND- 877 CUGGGCUGUUUCACCAAGUTsT 878 ACUUGGUGAAACAGCCCAGTsT 19% 6% 10579 ND- 879 AACAAUUACACCGUCAACATsT 880 UGUUGACGGUGUAAUUGUUTsT 13% 1% 10580 ND- 881 UGGGUAAGGGCUCAGGAAGTsT 882 CUUCCUGAGCCCUUACCCATsT 20% 3% 10581 ND- 883 GGGUAAGGGCUCAGGAAGUTsT 884 ACUUCCUGAGCCCUUACCCTsT 22% 3% 10582 ND- 885 CACCCAACUGCGGCUAAGUTsT 886 ACUUAGCCGCAGUUGGGUGTsT 22% 10% 10583 ND- 887 ACCCAACUGCGGCUAAGUCTsT 888 GACUUAGCCGCAGUUGGGUTsT 22% 5% 10584 ND- 889 CCAACUGCGGCUAAGUCUCTsT 890 GAGACUUAGCCGCAGUUGGTsT 14% 2% 10585 ND- 891 CUUGGAUCAGCCAAGCGAATsT 892 UUCGCUUGGCUGAUCCAAGTsT 15% 1% 10586 ND- 893 GCCAAGCGAAACUUGGAGCTsT 894 GCUCCAAGUUUCGCUUGGCTsT 17% 2% 10587 ND- 895 UCCUAAGAAACCGCUGAUATsT 896 UAUCAGCGGUUUCUUAGGATsT 11% 2% 10588 ND- 897 GCAUGCACGGGUUUCCUGCTsT 898 GCAGGAAACCCGUGCAUGCTsT 24% 8% 10589 ND- 899 UGUUACUUAGGCAAUUCCCTsT 900 GGGAAUUGCCUAAGUAACATsT 48% 10% 10590 ND- 901 CUAGGGCUAGAGCAGACCCTsT 902 GGGUCUGCUCUAGCCCUAGTsT 58% 10% 10591 ND- 903 CUCUAGCCUCAUACCCGUGTsT 904 CACGGGUAUGAGGCUAGAGTsT 34% 5% 10592 ND- 905 UUAGAACCCUGCUCAGACATsT 906 UGUCUGAGCAGGGUUCUAATsT 14% 1% 10593 ND- 907 UGUGAACGCUUCUGCCACATsT 908 UGUGGCAGAAGCGUUCACATsT 15% 0% 10594 ND- 909 AUUGAUCACUCCGCCUUCUTsT 910 AGAAGGCGGAGUGAUCAAUTsT 43% 1% 10595 ND- 911 UCACUCCGCCUUCUCCUGGTsT 912 CCAGGAGAAGGCGGAGUGATsT 90% 5% 10596 ND- 913 GCGGUCAGGGACUGAAUCUTsT 914 AGAUUCAGUCCCUGACCGCTsT 11% 0% 10597 ND- 915 GGUCAGGGACUGAAUCUUGTsT 916 CAAGAUUCAGUCCCUGACCTsT 13% 1% 10598 ND- 917 GUAUGCUCCAUGUCUAGCCTsT 918 GGCUAGACAUGGAGCAUACTsT 28% 3% 10599 ND- 919 CCAUGUCUAGCCCAUCAUCTsT 920 GAUGAUGGGCUAGACAUGGTsT 12% 1% 10600 ND- 921 GAUCGAGUUCCACCGCUCCTsT 922 GGAGCGGUGGAACUCGAUCTsT 17% 1% 10601 ND- 923 GGACUCUAGCCCUCCACAGTsT 924 CUGUGGAGGGCUAGAGUCCTsT 41% 4% 10602 ND- 925 UCACCACUCUCGUGGCCGGTsT 926 CCGGCCACGAGAGUGGUGATsT 83% 3% 10603 ND- 927 CAGCUUGCGGGACAACAACTsT 928 GUUGUUGUCCCGCAAGCUGTsT 21% 1% 10604 ND- 929 CAUCUUCUAUCCGCGGCCCTsT 930 GGGCCGCGGAUAGAAGAUGTsT 26% 2% 10605 ND- 931 AUAAGCUCCAGGUUGACUUTsT 932 AAGUCAACCUGGAGCUUAUTsT 15% 1% 10606 ND- 933 CUGCUGGUUACUCACGAUGTsT 934 CAUCGUGAGUAACCAGCAGTsT 85% 8% 10607 ND- 935 GAACAAUUACACCGUCAACTsT 936 GUUGACGGUGUAAUUGUUCTsT 13% 1% 10608 ND- 937 AUUACACCGUCAACAACAATsT 938 UUGUUGUUGACGGUGUAAUTsT 12% 0% 10609 ND- 939 CUGUGGUUCGGCUCCUCGGTsT 940 CCGAGGAGCCGAACCACAGTsT 53% 2% 10610 ND- 941 GAAGUGCCUUGGCUCCAGCTsT 942 GCUGGAGCCAAGGCACUUCTsT 24% 3% 10611 ND- 943 GAUCAGCCAAGCGAAACUUTsT 944 AAGUUUCGCUUGGCUGAUCTsT 12% 0% 10612 ND- 945 AGAAACCGCUGAUAACCAGTsT 946 CUGGUUAUCAGCGGUUUCUTsT 12% 1% 10613 ND- 947 UGAUAACCAGGACAAAACATsT 948 UGUUUUGUCCUGGUUAUCATsT 7% 1% 10614 ND- 949 CACGCAGGCAUGCACGGGUTsT 950 ACCCGUGCAUGCCUGCGUGTsT 12% 0% 10615 ND- 951 GCUCUCCAGUAGCACAGAUTsT 952 AUCUGUGCUACUGGAGAGCTsT 9% 1% 10616 ND- 953 CAGACCCGGGUAAGUAAAGTsT 954 CUUUACUUACCCGGGUCUGTsT 55% 3% 10617 ND- 955 AGACCCGGGUAAGUAAAGGTsT 956 CCUUUACUUACCCGGGUCUTsT 72% 8% 10618 ND- 957 AUCACUCCGCCUUCUCCUGTsT 958 CAGGAGAAGGCGGAGUGAUTsT 63% 6% 10619 ND- 959 CACUCCGCCUUCUCCUGGGTsT 960 CCCAGGAGAAGGCGGAGUGTsT 28% 1% 10620 ND- 961 AACUAGACUGUAAGUGCCUTsT 962 AGGCACUUACAGUCUAGUUTsT 23% 1% 10621 ND- 963 UAUGCUCCAUGUCUAGCCCTsT 964 GGGCUAGACAUGGAGCAUATsT 98% 2% 10622 ND- 965 CCCGAUGUAUGGAAACUGCTsT 966 GCAGUUUCCAUACAUCGGGTsT 11% 1% 10623 ND- 967 GUACUGCUACUAUAAGCUCTsT 968 GAGCUUAUAGUAGCAGUACTsT 19% 1% 10624 ND- 969 AGCGUGACCAGCUACCAGCTsT 970 GCUGGUAGCUGGUCACGCUTsT 49% 2% 10625 ND- 971 ACAAUUACACCGUCAACAATsT 972 UUGUUGACGGUGUAAUUGUTsT 8% 0% 10626 ND- 973 AUGCUCCUCUGGUGGGAGGTsT 974 CCUCCCACCAGAGGAGCAUTsT 76% 5% 10627 ND- 975 AACAGUAGCUGAUGAAGCUTsT 976 AGCUUCAUCAGCUACUGUUTsT 22% 1% 10628 ND- 977 CUGACUCCCGAGGGCUAGGTsT 978 CCUAGCCCUCGGGAGUCAGTsT 34% 2% 10629 ND- 979 GUGCAACCAGAACAAAUCGTsT 980 CGAUUUGUUCUGGUUGCACTsT 10% 1% 10630 ND- 981 UGCAACCAGAACAAAUCGGTsT 982 CCGAUUUGUUCUGGUUGCATsT 48% 4% 10631 ND- 983 CUUCAAAGUACACACAGCATsT 984 UGCUGUGUGUACUUUGAAGTsT 20% 1% 10632 ND- 985 CAGCGUGACCAGCUACCAGTsT 986 CUGGUAGCUGGUCACGCUGTsT 35% 1% 10633 ND- 987 AGAACAAUUACACCGUCAATsT 988 UUGACGGUGUAAUUGUUCUTsT 14% 0% 10634 ND- 989 GAUAACCAGGACAAAACACTsT 990 GUGUUUUGUCCUGGUUAUCTsT 11% 1% 10635 ND- 991 ACAACCAAGGGUACACGCATsT 992 UGCGUGUACCCUUGGUUGUTsT 17% 1% 10636 ND- 993 CCCAGCGACGGCUUAAGCCTsT 994 GGCUUAAGCCGUCGCUGGGTsT 27% 2% 10637 ND- 995 CUCCCGAGGGCUAGGGCUATsT 996 UAGCCCUAGCCCUCGGGAGTsT 23% 1% 10638 ND- 997 UAGAACCCUGCUCAGACACTsT 998 GUGUCUGAGCAGGGUUCUATsT 35% 2% 10639 ND- 999 CCUGGGCUGUUUCACCAAGTsT 1000 CUUGGUGAAACAGCCCAGGTsT 14% 1% 10640 ND- 1001 GGAUCAGCCAAGCGAAACUTsT 1002 AGUUUCGCUUGGCUGAUCCTsT 16% 3% 10641 ND- 1003 AAGAAACCGCUGAUAACCATsT 1004 UGGUUAUCAGCGGUUUCUUTsT 17% 1% 10642 ND- 1005 ACCAAGGGUACACGCAGGCTsT 1006 GCCUGCGUGUACCCUUGGUTsT 37% 4% 10643 ND- 1007 GUAGCACAGAUGUCUGCUCTsT 1008 GAGCAGACAUCUGUGCUACTsT 13% 3% 10644 ND- 1009 UUUCAUACCUCUACAUGUCTsT 1010 GACAUGUAGAGGUAUGAAATsT 88% 8% 10645 ND- 1011 CCAACCAUCUGCCAGAGAATsT 1012 UUCUCUGGCAGAUGGUUGGTsT 16% 2% 10646 ND- 1013 GUCAGGGACUGAAUCUUGCTsT 1014 GCAAGAUUCAGUCCCUGACTsT 16% 3% 10647 ND- 1015 AGCAUGAUCAAGGAGUGUGTsT 1016 CACACUCCUUGAUCAUGCUTsT 50% 7% 10648 ND- 1017 GCAGCGUGACCAGCUACCATsT 1018 UGGUAGCUGGUCACGCUGCTsT 40% 6% 10649 ND- 1019 CAGCUCUCUGCUGGUUACUTsT 1020 AGUAACCAGCAGAGAGCUGTsT 56% 5% 10650 ND- 1021 GUUCGGCUCCUCGGUGUUGTsT 1022 CAACACCGAGGAGCCGAACTsT 68% 5% 10651 ND- 1023 GCAGAUGCUCCUCUGGUGGTsT 1024 CCACCAGAGGAGCAUCUGCTsT 26% 5% 10652 ND- 1025 AGGAAGUUGCUCCAAGAACTsT 1026 GUUCUUGGAGCAACUUCCUTsT 18% 2% 10653 ND- 1027 AACGCUUCUGCCACAUCUUTsT 1028 AAGAUGUGGCAGAAGCGUUTsT 18% 1% 10654 ND- 1029 CACCUGGGCUGUUUCACCATsT 1030 UGGUGAAACAGCCCAGGUGTsT 17% 2% 10655 ND- 1031 AAGCCAUGCAGCGUGACCATsT 1032 UGGUCACGCUGCAUGGCUUTsT 27% 3% 10656 ND- 1033 CGAGGGCUAGGGCUAGAGCTsT 1034 GCUCUAGCCCUAGCCCUCGTsT 30% 1% 10657 ND- 1035 GGAAACCCUGGACAGACUUTsT 1036 AAGUCUGUCCAGGGUUUCCTsT 14% 1% 10658 ND- 1037 GUAGCUGAUGAAGCUGCCCTsT 1038 GGGCAGCUUCAUCAGCUACTsT 19% 1% 10659 ND- 1039 UCUUUUUCCCUUGGAUCAGTsT 1040 CUGAUCCAAGGGAAAAAGATsT 88% 4% 10660 ND- 1041 CUCCAGUAGCACAGAUGUCTsT 1042 GACAUCUGUGCUACUGGAGTsT 10% 1% 10661 ND- 1043 CCAAAAUUGAUCACUCCGCTsT 1044 GCGGAGUGAUCAAUUUUGGTsT 25% 3% 10662 ND- 1045 CAGACCACCUGGGCUGUUUTsT 1046 AAACAGCCCAGGUGGUCUGTsT 24% 2% 10663 ND- 1047 CCCUUCCCAACUAGACUGUTsT 1048 ACAGUCUAGUUGGGAAGGGTsT 15% 2% 10664 ND- 1049 CGCAGCCGUCGCGACCUGCTsT 1050 GCAGGUCGCGACGGCUGCGTsT 45% 2% 10665 ND- 1051 UUCUCACACCAAGGCAGAUTsT 1052 AUCUGCCUUGGUGUGAGAATsT 25% 2% 10666 ND- 1053 CACCACCAUCCACGGCGCCTsT 1054 GGCGCCGUGGAUGGUGGUGTsT 35% 3% 10667 ND- 1055 CCAUUACUUUUGUGAACGCTsT 1056 GCGUUCACAAAAGUAAUGGTsT 19% 4% 10668 ND- 1057 CCAAGAACAGUAGCUGAUGTsT 1058 CAUCAGCUACUGUUCUUGGTsT 23% 4% 16% 2% 10669 ND- 1059 AGGAGAGGUUUCUCACACCTsT 1060 GGUGUGAGAAACCUCUCCUTsT 18% 3% 17% 1% 10670 ND- 1061 AUCAUCCUGCUUGGAGCAATsT 1062 UUGCUCCAAGCAGGAUGAUTsT 33% 3% 24% 2% 10671 ND- 1063 GCAUCACAGAGCAGACGCUTsT 1064 AGCGUCUGCUCUGUGAUGCTsT 29% 2% 27% 4% 10672 ND- 1065 AGGAGGUAGCCUCCACCCUTsT 1066 AGGGUGGAGGCUACCUCCUTsT 65% 6% 61% 3% 10673 ND- 1067 ACAACCGCAUGAAGACGGCTsT 1068 GCCGUCUUCAUGCGGUUGUTsT 94% 2% 10674 ND- 1069 GCAUGAAGACGGCCUUCUGTsT 1070 CAGAAGGCCGUCUUCAUGCTsT 20% 2% 18% 1% 10675 ND- 1071 GUCACGAUGGUCACCCUCCTsT 1072 GGAGGGUGACCAUCGUGACTsT 66% 5% 60% 4% 10676 ND- 1073 CCCUGCUCAGACACCAUUATsT 1074 UAAUGGUGUCUGAGCAGGGTsT 15% 3% 18% 1% 10677 ND- 1075 UCACGAUGGUCACCCUCCUTsT 1076 AGGAGGGUGACCAUCGUGATsT 80% 6% 70% 4% 10678 ND- 1077 UCAACCUCAACUCGGACAATsT 1078 UUGUCCGAGUUGAGGUUGATsT 20% 3% 21% 1% 10679 ND- 1079 UGACCAGCUACCAGCUCUCTsT 1080 GAGAGCUGGUAGCUGGUCATsT 88% 22% 77% 5% 10680 ND- 1081 GAUGGCCCUCGGUGACAUCTsT 1082 GAUGUCACCGAGGGCCAUCTsT 88% 18% 60% 4% 10681 ND- 1083 GCUUUGACAAGGAACUUUCTsT 1084 GAAAGUUCCUUGUCAAAGCTsT 19% 7% 14% 2% 10682 ND- 1085 CGAUACUGGUCUCCAGGCCTsT 1086 GGCCUGGAGACCAGUAUCGTsT 27% 5% 27% 2% 10683 ND- 1087 UCUGGAUGUCUUCCAUGCCTsT 1088 GGCAUGGAAGACAUCCAGATsT 92% 13% 89% 3% 10684 ND- 1089 CAGGACCCUAGACCUCUGCTsT 1090 GCAGAGGUCUAGGGUCCUGTsT 58% 14% 50% 2% 10685 ND- 1091 GACCCUAGACCUCUGCAGCTsT 1092 GCUGCAGAGGUCUAGGGUCTsT 27% 2% 10686 ND- 1093 ACCCUAGACCUCUGCAGCCTsT 1094 GGCUGCAGAGGUCUAGGGUTsT 21% 1% 10687 ND- 1095 CAGCCCACGGCGGAGGAGGTsT 1096 CCUCCUCCGCCGUGGGCUGTsT 55% 4% 10688 ND- 1097 CUCUUCGAGUUCUUCUGCATsT 1098 UGCAGAAGAACUCGAAGAGTsT 13% 3% 10689 ND- 1099 UUGGCAUGAUGUACUGGCATsT 1100 UGCCAGUACAUCAUGCCAATsT 16% 2% 10690 ND- 1101 GGCAUGAUGUACUGGCAAUTsT 1102 AUUGCCAGUACAUCAUGCCTsT 13% 1% 10691 ND- 1103 UGUACUGGCAAUUCGGCCUTsT 1104 AGGCCGAAUUGCCAGUACATsT 45% 2% 10692 ND- 1105 ACUGGCAAUUCGGCCUGCUTsT 1106 AGCAGGCCGAAUUGCCAGUTsT 38% 3% 10693 ND- 1107 GGCAAUUCGGCCUGCUUUUTsT 1108 AAAAGCAGGCCGAAUUGCCTsT 10% 1% 10694 ND- 1109 CAAUUCGGCCUGCUUUUCGTsT 1110 CGAAAAGCAGGCCGAAUUGTsT 12% 1% 10695 ND- 1111 UCGGAGAGUACUUCAGCUATsT 1112 UAGCUGAAGUACUCUCCGATsT 12% 1% 10696 ND- 1113 CAACAUCCUGUCGAGGCUGTsT 1114 CAGCCUCGACAGGAUGUUGTsT 35% 7% 10697 ND- 1115 CAUCCUGUCGAGGCUGCCATsT 1116 UGGCAGCCUCGACAGGAUGTsT 26% 6% 10698 ND- 1117 UCCUGCAACCAGGCGAAUUTsT 1118 AAUUCGCCUGGUUGCAGGATsT 28% 6% 10699 ND- 1119 GGAAACUGCUAUACUUUCATsT 1120 UGAAAGUAUAGCAGUUUCCTsT 7% 2% 10700 ND- 1121 ACGGUCUGUCCCUGAUGCUTsT 1122 AGCAUCAGGGACAGACCGUTsT 28% 7% 10701 ND- 1123 GGUCUGUCCCUGAUGCUGCTsT 1124 GCAGCAUCAGGGACAGACCTsT 33% 2% 10702 ND- 1125 GGCCCGGGUAAUGGUGCACTsT 1126 GUGCACCAUUACCCGGGCCTsT 47% 10% 10703 ND- 1127 CAGGAUGAACCUGCCUUUATsT 1128 UAAAGGCAGGUUCAUCCUGTsT 59% 2% 10704 ND- 1129 GAUGAACCUGCCUUUAUGGTsT 1130 CCAUAAAGGCAGGUUCAUCTsT 77% 7% 10705 ND- 1131 GGUGGCUUUAACUUGCGGCTsT 1132 GCCGCAAGUUAAAGCCACCTsT 47% 8% 10706 ND- 1133 GUGGCUUUAACUUGCGGCCTsT 1134 GGCCGCAAGUUAAAGCCACTsT 17% 2% 10707 ND- 1135 UUGCGGCCUGGCGUGGAGATsT 1136 UCUCCACGCCAGGCCGCAATsT 52% 3% 10708 ND- 1137 UGCGGCCUGGCGUGGAGACTsT 1138 GUCUCCACGCCAGGCCGCATsT 81% 4% 10709 ND- 1139 GCGGCCUGGCGUGGAGACCTsT 1140 GGUCUCCACGCCAGGCCGCTsT 57% 4% 10710 ND- 1141 CAGGUGUGUAUUCACUCCUTsT 1142 AGGAGUGAAUACACACCUGTsT 24% 2% 10711 ND- 1143 GUGUAUUCACUCCUGCUUCTsT 1144 GAAGCAGGAGUGAAUACACTsT 20% 1% 10712 ND- 1145 GGCCCUCGGUGACAUCCCATsT 1146 UGGGAUGUCACCGAGGGCCTsT 40% 3% 10713 ND- 1147 GAUGCUAUCGCGACAGAACTsT 1148 GUUCUGUCGCGAUAGCAUCTsT 24% 2% 10714 ND- 1149 ACUACAAAACCAAUUCUGATsT 1150 UCAGAAUUGGUUUUGUAGUTsT 19% 2% 10715 ND- 1151 CAAUUCUGAGUCUCCCUCUTsT 1152 AGAGGGAGACUCAGAAUUGTsT 35% 3% 10716 ND- 1153 CUCUGUCACGAUGGUCACCTsT 1154 GGUGACCAUCGUGACAGAGTsT 41% 4% 10717 ND- 1155 CUGCUCCGAAGGUUCCGAATsT 1156 UUCGGAACCUUCGGAGCAGTsT 16% 3% 10718 ND- 1157 AGGUUCCGAAGCCGAUACUTsT 1158 AGUAUCGGCUUCGGAACCUTsT 16% 2% 10719 ND- 1159 GUUCCGAAGCCGAUACUGGTsT 1160 CCAGUAUCGGCUUCGGAACTsT 21% 2% 10720 ND- 1161 CGAAGCCGAUACUGGUCUCTsT 1162 GAGACCAGUAUCGGCUUCGTsT 16% 1% 10721 ND- 1163 AAGAUUGAAGGAUGUGCAGTsT 1164 CUGCACAUCCUUCAAUCUUTsT 25% 2% 10722 ND- 1165 GAUUGAAGGAUGUGCAGGGTsT 1166 CCCUGCACAUCCUUCAAUCTsT 26% 1% 10723 ND- 1167 UGCCUCUGAACACUCUGGUTsT 1168 ACCAGAGUGUUCAGAGGCATsT 45% 3% 10724 ND- 1169 CCUCUGAACACUCUGGUUUTsT 1170 AAACCAGAGUGUUCAGAGGTsT 15% 2% 10725 ND- 1171 GACAAGGAACUUUCCUAAGTsT 1172 CUUAGGAAAGUUCCUUGUCTsT 105% 14% 10726 ND- 1173 CAGGACAAAACACAACCAATsT 1174 UUGGUUGUGUUUUGUCCUGTsT 32% 5% 10727 ND- 1175 AACACAACCAAGGGUACACTsT 1176 GUGUACCCUUGGUUGUGUUTsT 60% 13% 10728 ND- 1177 UUGAACUUGGGUGGGAAACTsT 1178 GUUUCCCACCCAAGUUCAATsT 23% 8% 10729 ND- 1179 UGAACUUGGGUGGGAAACCTsT 1180 GGUUUCCCACCCAAGUUCATsT 18% 4% 10730 ND- 1181 ACCCGUGCCCUCACAGAGCTsT 1182 GCUCUGUGAGGGCACGGGUTsT 19% 1% 10731 ND- 1183 ACUAUAACAUCUGCUGGAGTsT 1184 CUCCAGCAGAUGUUAUAGUTsT 17% 5% 10732 ND- 1185 AUCUGCUGGAGUGUUGCUGTsT 1186 CAGCAACACUCCAGCAGAUTsT 119% 20% 10733 ND- 1187 CUGCUGGAGUGUUGCUGUUTsT 1188 AACAGCAACACUCCAGCAGTsT 58% 13% 10734 ND- 1189 CUAGCCCAUCAUCCUGCUUTsT 1190 AAGCAGGAUGAUGGGCUAGTsT 20% 6% 10735 ND- 1191 CUCUGGAUGUCUUCCAUGCTsT 1192 GCAUGGAAGACAUCCAGAGTsT 28% 8% 10736 ND- 1193 AGCAGGACCCUAGACCUCUTsT 1194 AGAGGUCUAGGGUCCUGCUTsT 38% 2% 10737 ND- 1195 UUCGAGUUCUUCUGCAACATsT 1196 UGUUGCAGAAGAACUCGAATsT 13% 1% 10738 ND- 1197 CACCAUCCACGGCGCCAUCTsT 1198 GAUGGCGCCGUGGAUGGUGTsT 13% 2% 10739 ND- 1199 CCACGGCGCCAUCCGCCUGTsT 1200 CAGGCGGAUGGCGCCGUGGTsT 44% 4% 10740 ND- 1201 CAGCACAACCGCAUGAAGATsT 1202 UCUUCAUGCGGUUGUGCUGTsT 23% 3% 10741 ND- 1203 CCUUUGGCAUGAUGUACUGTsT 1204 CAGUACAUCAUGCCAAAGGTsT 12% 1% 10742 ND- 1205 AUCCUGUCGAGGCUGCCAGTsT 1206 CUGGCAGCCUCGACAGGAUTsT 14% 3% 10743 ND- 1207 UCUCCUGCAACCAGGCGAATsT 1208 UUCGCCUGGUUGCAGGAGATsT 12% 1% 10744 ND- 1209 UGCAACCAGGCGAAUUACUTsT 1210 AGUAAUUCGCCUGGUUGCATsT 45% 5% 10745 ND- 1211 ACCUCCAUCAGCAUGAGGATsT 1212 UCCUCAUGCUGAUGGAGGUTsT 82% 7% 10746 ND- 1213 GCGACUGCACCAAGAAUGGTsT 1214 CCAUUCUUGGUGCAGUCGCTsT 82% 19% 10747 ND- 1215 ACCAAGAAUGGCAGUGAUGTsT 1216 CAUCACUGCCAUUCUUGGUTsT 54% 18% 10748 ND- 1217 UGGUUACUCACGAUGGCCCTsT 1218 GGGCCAUCGUGAGUAACCATsT 45% 7% 10749 ND- 1219 AGAAAUGGAGUGGCCAAAGTsT 1220 CUUUGGCCACUCCAUUUCUTsT 11% 3% 10750 ND- 1221 GGAGCUGAACUACAAAACCTsT 1222 GGUUUUGUAGUUCAGCUCCTsT 15% 3% 10751 ND- 1223 CCUCUGUCACGAUGGUCACTsT 1224 GUGACCAUCGUGACAGAGGTsT 18% 5% 10752 ND- 1225 AGAUUGAAGGAUGUGCAGGTsT 1226 CCUGCACAUCCUUCAAUCUTsT 26% 3% 10753 ND- 1227 GAGCUUUGACAAGGAACUUTsT 1228 AAGUUCCUUGUCAAAGCUCTsT 14% 2% 10754 ND- 1229 CUUUGACAAGGAACUUUCCTsT 1230 GGAAAGUUCCUUGUCAAAGTsT 50% 8% 10755 ND- 1231 UCAGACACCAUUACUUUUGTsT 1232 CAAAAGUAAUGGUGUCUGATsT 32% 4% 10756 ND- 1233 AGCACACUAUAACAUCUGCTsT 1234 GCAGAUGUUAUAGUGUGCUTsT 11% 2% 10757 ND- 1235 GCACAACCGCAUGAAGACGTsT 1236 CGUCUUCAUGCGGUUGUGCTsT 34% 3% 10758 ND- 1237 ACUGCUUCUACCAGACAUATsT 1238 UAUGUCUGGUAGAAGCAGUTsT 11% 1% 10759 ND- 1239 GAAGACGGCCUUCUGGGCATsT 1240 UGCCCAGAAGGCCGUCUUCTsT 16% 2% 10760 ND- 1241 AAGACGGCCUUCUGGGCAGTsT 1242 CUGCCCAGAAGGCCGUCUUTsT 58% 21% 10761 ND- 1243 ACAUCAACCUCAACUCGGATsT 1244 UCCGAGUUGAGGUUGAUGUTsT 14% 3% 10762 ND- 1245 UGGAAGGACUGGAAGAUCGTsT 1246 CGAUCUUCCAGUCCUUCCATsT 109% 29% 10763 ND- 1247 ACAUCCUGUCGAGGCUGCCTsT 1248 GGCAGCCUCGACAGGAUGUTsT 101% 13% 10764 ND- 1249 CAACCAGGCGAAUUACUCUTsT 1250 AGAGUAAUUCGCCUGGUUGTsT 19% 5% 10765 ND- 1251 CAGGCGAAUUACUCUCACUTsT 1252 AGUGAGAGUAAUUCGCCUGTsT 24% 4% 10766 ND- 1253 AGCAGAAUGACUUCAUUCCTsT 1254 GGAAUGAAGUCAUUCUGCUTsT 40% 8% 10767 ND- 1255 AUGAUGGUGGCUUUAACUUTsT 1256 AAGUUAAAGCCACCAUCAUTsT 85% 8% 10768 ND- 1257 AGAACCUUUACCCUUCAAATsT 1258 UUUGAAGGGUAAAGGUUCUTsT 22% 4% 10769 ND- 1259 CCUUUACCCUUCAAAGUACTsT 1260 GUACUUUGAAGGGUAAAGGTsT 21% 4% 10770 ND- 1261 GAGCCUGUGGUUCGGCUCCTsT 1262 GGAGCCGAACCACAGGCUCTsT 28% 1% 10771 ND- 1263 UGGUACUGCCUCUGAACACTsT 1264 GUGUUCAGAGGCAGUACCATsT 58% 4% 10772 ND- 1265 CUCAUACCCGUGCCCUCACTsT 1266 GUGAGGGCACGGGUAUGAGTsT 15% 2% 10773 ND- 1267 CCGUAGCACACUAUAACAUTsT 1268 AUGUUAUAGUGUGCUACGGTsT 24% 6% 10774 ND- 1269 CGUAGCACACUAUAACAUCTsT 1270 GAUGUUAUAGUGUGCUACGTsT 21% 4% 10775 ND- 1271 GCAGGACCCUAGACCUCUGTsT 1272 CAGAGGUCUAGGGUCCUGCTsT 25% 4% 10776 ND- 1273 GCCUGCUUUUCGGAGAGUATsT 1274 UACUCUCCGAAAAGCAGGCTsT 18% 4% 10777 ND- 1275 GGGCCCGGGUAAUGGUGCATsT 1276 UGCACCAUUACCCGGGCCCTsT 16% 2% 10778 ND- 1277 CAACAACAAGAGAAAUGGATsT 1278 UCCAUUUCUCUUGUUGUUGTsT 17% 0% 10779 ND- 1279 GCUGUUGCACCAUACUUUCTsT 1280 GAAAGUAUGGUGCAACAGCTsT 14% 1% 10780 ND- 1281 CUACCGAGAGCUCUUCGAGTsT 1282 CUCGAAGAGCUCUCGGUAGTsT 24% 3% 10781 ND- 1283 ACCUGCCUUUAUGGAUGAUTsT 1284 AUCAUCCAUAAAGGCAGGUTsT 115% 10% 10782 ND- 1285 UUGACAAGGAACUUUCCUATsT 1286 UAGGAAAGUUCCUUGUCAATsT 16% 1% 10783 ND- 1287 GCUGGAGUGUUGCUGUUGCTsT 1288 GCAACAGCAACACUCCAGCTsT 12% 1% 10784 ND- 1289 UCGGUGACAUCCCAGGAAUTsT 1290 AUUCCUGGGAUGUCACCGATsT 28% 1% 10785 ND- 1291 GCUGCCCAGAAGUGCCUUGTsT 1292 CAAGGCACUUCUGGGCAGCTsT 15% 2% 10786 ND- 1293 AGUACACACAGCAGGUGUGTsT 1294 CACACCUGCUGUGUGUACUTsT 12% 1% 10787 ND- 1295 CAAGUGCCGGAAGCCAUGCTsT 1296 GCAUGGCUUCCGGCACUUGTsT 94% 2% 10788 TABLE 1C Selected siRNAs in in vivo rat surrogate set (human-rat cross-reactive siRNAs with highest specificity in rat).", "A screening set of 48 human and rat cross-reactive alpha-ENaC iRNA sequences were identified.", "The percentage residual expression of alpha-ENaC in two independent single-dose transfection experiments is shown (refer to examples section for methods used).", "1st screen single dose @ 2nd 50 nM screen Duplex Seq Seq in H441; @ 50 nM ID ID Sense ID Antissense MV SD in H441 SD ND-9201 1297 uGuGcAAccAGAAcAAAucTsT 1298 GAUUUGUUCUGGUUGcAcATsT 8% 1% 8% 1% ND-9202 1299 uuuAuGGAuGAuGGuGGcuTsT 1300 AGCcACcAUcAUCcAuAAATsT 80% 9% 82% 6% ND-9203 1301 GccuuuAuGGAuGAuGGuGTsT 1302 cACcAUcAUCcAuAAAGGCTsT 76% 8% 76% 2% ND-9204 1303 cAcAAccGcAuGAAGAcGGTsT 1304 CCGUCUUcAUGCGGUUGUGTsT 73% 18% 57% 3% ND-9205 1305 AccGcAuGAAGAcGGccuuTsT 1306 AAGGCCGUCUUcAUGCGGUTsT 35% 3% 37% 2% ND-9206 1307 AGGAcuGGAAGAucGGcuuTsT 1308 AAGCCGAUCUUCcAGUCCUTsT 17% 3% 16% 3% ND-9207 1309 GAAGGAcuGGAAGAucGGcTsT 1310 GCCGAUCUUCcAGUCCUUCTsT 96% 18% 81% 5% ND-9208 1311 GGAcuGGAAGAucGGcuucTsT 1312 GAAGCCGAUCUUCcAGUCCTsT 58% 6% 57% 2% ND-9209 1313 AGuuccAccGcuccuAccGTsT 1314 CGGuAGGAGCGGUGGAACUTsT 85% 8% 94% 4% ND-9210 1315 GAcuGGAAGAucGGcuuccTsT 1316 GGAAGCCGAUCUUCcAGUCTsT 79% 5% 82% 2% ND-9211 1317 cGcAuGAAGAcGGccuucuTsT 1318 AGAAGCCCGUCUUcAUGCGTsT 50% 1% 51% 1% ND-9212 1319 GccAGuGGAGccuGuGGuuTsT 1320 AACcAcAGGCUCcACUGGCTsT 26% 3% 23% 2% ND-9213 1321 uGccuuuAuGGAuGAuGGuTsT 1322 ACcAUcAUCcAuAAAGGcATsT 77% 5% 76% 4% ND-9214 1323 uccuGuccAAccuGGGcAGTsT 1324 CUGCCcAGGUUGGAcAGGATsT 74% 9% 83% 6% ND-9215 1325 AGGGAGuGGuAccGcuuccTsT 1326 GGAAGCGGuACcACUCCCUTsT 79% 6% 89% 4% ND-9216 1327 GGcuGuGccuAcAucuucuTsT 1328 AGAAGAUGuAGGcAcAGCCTsT 11% 1% 13% 1% ND-9217 1329 GAAAuuAAAGAGGAGcuGGTsT 1330 CcAGCUCCUCUUuAAUUUCTsT 84% 14% 78% 5% ND-9218 1331 AcuGGAAGAucGGcuuccATsT 1332 UGGAAGCCGAUCUUCCAGUTsT 50% 4% 55% 3% ND-9219 1333 ccuGuccAAccuGGGcAGcTaT 1334 GCUGCCcAGGUUGGAcAGGTsT 78% 6% 85% 5% ND-9220 1335 ccuGccuuuAuGGAuGAuGTsT 1336 cAUcAUCcAuAAAGGcAGGTsT 76% 5% 77% 9% ND-9221 1337 AAccGcAuGAAGAcGGccuTsT 1338 AGGCCGUCUUcAUGCGGUUTsT 79% 8% 66% 3% ND-9222 1339 uGuccAAccuGGGcAGccATsT 1340 UGGCUGCCcAGGUUGGAcATsT 70% 4% 57% 4% ND-9223 1341 GuccAAccuGGGcAGccAGTsT 1342 CUGGCUGCCcAGGUUGGACTsT 95% 10% 76% 4% ND-9224 1343 AAAuuAAAGAGGAGcuGGATsT 1344 UCcAGCUCCUCUUuAAUUUTsT 83% 6% 69% 2% ND-9225 1345 GGAAGGAcuGGAAGAucGGTsT 1346 CCGAUCUUCcAGUCCUUCCTsT 41% 2% 30% 2% ND-9226 1347 GuGAGGGAGuGGuAccGcuTsT 1348 AGCGGuAGcAGUCCCUcACTsT 21% 1% 17% 0% ND-9227 1349 AcuuucAAuGAcAAGAAcATsT 1350 UGUUCUUGUcAUUGAAAGUTsT 13% 1% 10% 0% ND-9228 1351 ucAAuGAcAAGAAcAAcucTsT 1352 GAGUUGUUCUUGUcAUUGATsT 36% 2% 28% 0% ND-9229 1353 cuuuAuGGAuGAuGGuGGcTsT 1354 GCcACcAUcAUCcAuAAAGTsT 24% 1% 20% 1% ND-9230 1355 GccuGGcGuGGAGAccuccTsT 1356 GGAGGUCUCcACGCcAGGCTsT ND-9231 1357 uGGcGuGGAGAccuccAucTsT 1358 GAUGGAGGUCUCcACGCcATsT 45% 4% 35% 2% ND-9232 1359 GAGuuccAccGcuccuAccTsT 1360 GGuAGGAGCGGUGGAACUCTsT 89% 4% 86% 8% ND-9233 1361 cAGAGcAGAAuGAcuucAuTsT 1362 AUGAAGUcAUUCUGCUCUGTsT 21% 1% 17% 0% ND-9234 1363 uucAcuccuGcuuccAGGATsT 1364 UCCUGGAAGcAGGAGUGAATsT 85% 4% 74% 5% ND-9235 1365 ucAcuccuGcuuccAGGAGTsT 1366 CUCCUGGAAGcAGGAGUGATsT ND-9236 1367 cuGuGcAAccAGAAcAAAuTsT 1368 AUUUGUUCUGGUUGcAcAGTsT 23% 1% 17% 2% ND-9237 1369 cuGcAAcAAcAccAccAucTsT 1370 GAUGGUGGUGUUGUUGcAGTsT 34% 2% 27% 2% ND-9238 1371 uGuGGcuGuGccuAcAucuTsT 1372 AGAUGuAGGCAcAGCcAcATsT 86% 4% 73% 10% ND-9239 1373 uGGcuGuGccuAcAucuucTsT 1374 GAAGAUGuAGGcAcAGCcATsT 68% 6% 53% 4% ND-9240 1375 cuGuccAAccuGGGcAGccTsT 1376 GGCUGCCcAGGUUGGAcAGTsT 80% 5% 73% 9% ND-9241 1377 cccuGcuGuccAcAGuGAcTsT 1378 GUcACUGUGGAcAGCAGGGTsT 83% 5% 71% 5% ND-9242 1379 GcAGccAGuGGAGccuGuGTsT 1380 cAcAGGCUCcACUGGCUGCTsT 105% 3% 90% 5% ND-9243 1381 uucAAuGAcAAGAAcAAcuTsT 1382 AGUUGUUCUUGUcAUUGAATsT 23% 3% 21% 1% ND-9244 1383 cuGccuuuAuGGAuGAuGGTsT 1384 CcAUcAUCcAuAAAGGCAGTsT 74% 6% 64% 7% ND-9245 1385 AAuGAcAAGAAcAAcuccATsT 1386 UGGAGUUGUUCUUGUcAUUTsT 21% 1% 21% 1% ND-9246 1387 uGGGcAGccAGuGGAGccuTsT 1388 AGGCUCcACUGGCUGCCcATsT 83% 3% 73% 2% ND-9247 1389 cuccuGuccAAccuGGGcATsT 1390 UGCCcAGGUUGGAcAGGAGTsT 86% 3% 84% 1% ND-9248 1391 GGcGuGGAGAccuccAucATsT 1392 UGAUGGAGGUCUCCACGCCTsT 92% 4% 88% 3% TABLE 1D Selected siRNAs in in vivo guinea pig surrogate set (human-guinea pig cross-reactive siRNAs).", "A screening set of 63 human and guinea-pig cross-reactive alpha- ENaC iRNA sequences were identified and synthesised, both with (sequence strands 1393- 1518) and without (sequence strands 1519-1644) backbone modification.", "The percentage residual expression of alpha-ENaC in two independent single-dose transfection experiments is shown (refer to examples section for methods used).", "1st screen single dose @ 50 nM 2nd screen Duplex Seq Seq in H441; @ 50 nM ID ID Sense ID Antissense MV SD in H441 SD ND8437 1393 AAucGGAcuGcuucuAccATsT 1394 UGGuAGAAGcAGUCCGAUUTsT 48% 7% 46% 5% ND8438 1395 AucGGAcuGcuucuAcCAGTsT 1396 CUGGuAGAAGcAGUCCGAUTsT 85% 5% 93% 13% ND8439 1397 AAAucGGAcuGcuacuAccTsT 1398 GGuAGAAGcAGUCCGAUUUTsT 36% 3% 42% 6% NDB440 1399 ucGGAcuGcuucuAccAGATsT 1400 UCUGGuAGAAGcAGUCCGATsT 45% 3% 50% 4% ND8441 1401 AccAGAAcAAAucGGAcUGTsT 1402 cAGUCCGAUUUGUUCUGGUTsT 23% 3% 24% 6% ND8442 1403 ccAGAAcAAAucGGAcuGcTsT 1404 GcAGUCCGAUUUGUUCUGGTsT 50% 6% 39% 9% ND8443 1405 cAGAAcAAAucGGAcuGcuTsT 1406 AGcAGUCCGAUUUGUUCUGTsT 22% 2% 24% 1% ND8444 1407 cuucGccuGccGcuucAAcTsT 1408 GUUGAAGCGGcAGGCGAAGTsT 111% 8% 109% 4% ND8445 1409 uGGuAccGcuuccAcuAcATsT 1410 UGuAGUGGAAGCGGuACcATsT 84% 7% 97% 13% ND8446 1411 AucuucGCOUGccGcuucATsT 1412 UGAAGCGGcAGGCGAAGAUTsT 90% 3% 121% 13% ND8447 1413 UUcGccuGccGcuucAAccTsT 1414 GGUUGAAGCGGcAGGCGAATsT 92% 2% 105% 17% ND8448 1415 cAcccucAAucccuAcAGGTsT 1416 CCUGuAGGGAUUGAGGGUGTsT 79% 3% 90% 13% ND8449 1417 AGAAcAAAucGGAcuGcuuTsT 1418 AAGcAGUCCGAUUUGUUCUTsT 11% 0% 17% 3% ND8450 1419 GAAcAAAucGGAcuGcuucTsT 1420 GAAGcAGUCCGAUUUGUUCTsT 21% 1% 30% 5% ND8451 1421 cGGAcuGcuucuAccAGAcTsT 1422 GUCUGGuAGAAGcAGUCCGTsT 24% 2% 32% 5% ND8452 1423 AGccucAAcAucAAccucATsT 1424 UGAGGUUGAUGUUGAGGCUTsT 51% 3% 57% 4% ND8453 1425 GccucAAcAucAAccucAATsT 1426 UUGAGGUUGAUGUUGAGGCTsT 16% 1% 26% 3% ND8454 1427 GucAGccUcAAcAucAAccTsT 1428 GGUUGAUGUUGAGGCUGACTsT 62% 5% 68% 6% ND8455 1429 UcAGccucAAcAucAAccuTsT 1430 AGGUUGAUGUUGAGGCUGATsT 77% 4% 87% 6% ND8456 1431 CAGccucAAcAucAAccucTsT 1432 GAGGUUGAUGUUGAGGCUGTsT 34% 2% 51% 8% ND8457 1433 GGAGcuGGAccGcAucAcATsT 1434 UGUGAUGCGGUCcAGCUCCTsT 26% 2% 17% 1% ND8458 1435 GuAccGcuuccAcuAcAucTsT 1436 GAUGuAGUGGAAGCGGuACTsT 101% 9% 99% 11% ND8459 1437 ccGcuuccAcuAcAucAAcTsT 1430 GUUGAUGuAGUGGAAGCGGTsT 85% 8% 80% 6% ND8460 1439 cGcuuccAcuAcAucAAcATsT 1440 UGUUGAUGuAGUGGAAGCGTsT 56% 6% 48% 3% ND8461 1441 uuccAcuAcAucAAcAuccTsT 1442 GGAUGUUGAUGuAGUGGAATsT 77% 5% 82% 7% ND8462 1443 uGGGcAAcuucAucuucGcTsT 1444 GCGAAGAUGAAGUUGCCcATsT 21% 0% 36% 6% ND8463 1445 GcAAcuucAucuucGccuGTsT 1446 CAGGCGAAGAUGAAGUUGCTsT 80% 4% 84% 13% ND8464 1447 cAACUUCAUCUUCGCCUGcTsT 1448 GcAGGCGAAGAUGAAGUUGTsT 101% 1% 102% 14% ND8465 1449 AAcuacAucuucGccuGccTsT 1450 GGcAGGCGAAGAUGAAGUUTsT 100% 4% 95% 12% ND8466 1451 AcuucAucuucGcCUGccGTsT 1452 CGGcAGGCGAAGAUGAAGUTsT 51% 4% 49% 5% ND8467 1453 cuucAucuucGccuGccGcTsT 1454 GCGGcAGGCGAAGAUGAAGTsT 95% 5% 89% 4% ND8468 1455 ucAucuucGccuGccGcuuTsT 1456 AAGCGGcAGGCGAAGAUGATsT 91% 4% 85% 6% ND8469 1457 cAucuucGccuGccGcuucTsT 1458 GAAGCGGcAGGCGAAGAUGTsT 66% 4% 55% 4% ND8470 1459 UcuucGccuGccGcuucAATsT 1460 UUGAAGCGGcAGGCGAAGATsT 97% 2% 99% 11% ND8471 1461 cGccuGccGcuucAAccAGTsT 1462 CUGGUUGAAGCGGcAGGCGTsT 96% 4% 100% 7% ND8472 1463 GccuGccGcuucAAccAGGTsT 1464 CCUGGUUGAAGCGGcAGGCTsT 90% 4% 82% 5% ND8473 1465 AuuAcucucAcuuccAccATsT 1466 UGGUGGAAGUGAGAGuAAUTsT 81% 3% 72% 4% ND8474 1467 uuAcucucAcuuccAccAcTsT 1468 GUGGUGGAAGUGAGAGuAATsT 72% 2% 76% 9% ND8475 1469 AcucucAcuuccAccAcccTsT 1470 GGGUGGUGGAAGUGAGAGUTsT 90% 3% 97% 4% ND8476 1471 ucuGcAcccucAAucccuATsT 1472 uAGGGAUUGAGGGUGcAGATsT 61% 1% 63% 3% ND8477 1473 cuGcAcccucAAucccuAcTsT 1474 GUAGGGAUUGAGGGUGcAGTsT 74% 3% 73% 1% ND8478 1475 uGcAcccucAAucccuAcATsT 1476 UGuAGGGAUUGAGGGUGcATsT 98% 4% 85% 1% ND8479 1477 AcccucAAucccuAcAGGuTsT 1478 ACCUGuAGGGAUUGAGGGUTsT 55% 5% 48% 3% ND8480 1479 cccucAAucccuAcAGGuATsT 1480 uACCUGuAGGGAUUGAGGGTsT 20% 1% 14% 1% ND0481 1481 ccucAAucccuAcAGGuAcTsT 1482 GuACCUGuAGGGAUUGAGGTsT 40% 2% 31% 3% ND8482 1483 AAccAGAAcAAAUcGGAcuTsT 1484 AGUCCGAUUUGUUCUGGUUTsT 57% 2% 52% 0% ND8483 1485 AAcAAAucGGAcuGcuucuTsT 1486 AGAAGcAGUCCGAUUUGUUTsT 102% 5% 86% 12% ND8484 1487 AcAAAucGGAcuGcuucuATsT 1488 uAGAAGcAGUCCGAUUUGUTsT 40% 2% 28% 3% ND8485 1489 CAAAUCGGACUGCUUCUACTsT 1490 GUAGAAGcAGUCCGAUUUGTsT 41% 4% 38% 2% ND8486 1491 GcAcccucAAucccuAcAGTsT 1492 CUGuAGGGAUUGAGGGUGCTsT 91% 7% 94% 4% ND8487 1493 CCUCAACAUCAACCUCAACTsT 1494 GUUGAGGUUGAUGUUGAGGTsT 46% 2% 37% 3% ND8488 1495 cucAAcAucAAcCUCAACUTsT 1496 AGUUGAGGUUGAUGUUGAGTsT 48% 2% 39% 3% ND8489 1497 ucAAcAucAAccucAAcucTsT 1498 GAGUUGAGGUUGAUGUUGATsT 17% 1% 17% 1% ND8490 1499 uAccGcuuccAcuAcAucATsT 1500 UGAUGuAGUGGAAGCGGuATsT 90% 5% 74% 0% ND8491 1501 AccGcuuccAcuAcAucAATsT 1502 UUGAUGuAGUGGAAGCGGUTsT 103% 5% 91% 15% ND8492 1503 GcuuccAcuAcAucAAcAuTsT 1504 AUGUUGAUGuAGUGGAAGGTsT 85% 5% 71% 10% ND8493 1505 cuuccAcuAcAucAAcAucTsT 1506 GAUGUUGAUGUAGUGGAAGTsT 60% 5% 45% 3% ND8494 1507 uccAcuAcAucAAcAuccuTsT 1508 AGGAUGUUGAUGuAGUGGATsT 33% 3% 41% 3% ND8495 1509 ccAcuAcAucAAcAuccuGTsT 1510 CAGGAUGUUGAUGUAGUGGTsT 60% 5% 55% 2% ND8496 1511 cuGGGcAAcuacAucuucGTsT 1512 CGAAGAUGAAGUUGCCcAGTsT 18% 0% 20% 0% ND8497 1513 GGcAAcuucAucuucGccuTsT 1514 AGGCGAAGAUGAAGUUGCCTsT 76% 1% 77% 2% ND8498 1515 uucAacuucGccuGccGcuTsT 1516 AGCGGcAGGCGAAGAUGAATsT 65% 4% 74% 12% ND8499 1517 ucGccuGccGcuucAAccATsT 1518 UGGUUGAAGCGGcAGGCGATsT 86% 5% 77% 3% ND-8653 1519 AAUCGGACUGCUUCUACCATsT 1520 UGGUAGAAGCAGUCCGAUUTsT 16% 2% 20% 3% ND-8654 1521 AUCGGACUGCUUCUACCAGTsT 1522 CUGGUAGAAGCAGUCCGAUTsT 54% 8% 67% 11% ND-8655 1523 AAAUCGGACUGCUUCUACCTsT 1524 GGUAGAAGCAGUCCGAUUUTsT 25% 4% 28% 2% ND-8656 1525 UCGGACUGCUUCUACCAGATsT 1526 UCUGGUAGAAGCAGUCCGATsT 12% 2% 17% 1% ND-8657 1527 ACCAGAACAAAUCGGACUGTsT 1528 CAGUCCGAUUUGUUCUGGUTsT 33% 3% 35% 1% ND-8658 1529 CCAGAACAAAUCGGACUGCTsT 1530 GCAGUCCGAUUUGUUCUGGTsT 27% 3% 30% 2% ND-8659 1531 CAGAACAAAUCGGACUGCUTsT 1532 AGCAGUCCGAUUUGUUCUGTsT 15% 1% 22% 3% ND-8660 1533 CUUCGCCUGCCGCUUCAACTsT 1534 GUUGAAGCGGCAGGCGAAGTsT 69% 17% 75% 10% ND-8661 1535 UGGUACCGCUUCCACUACATsT 1536 UGUAGUGGAAGCGGUACCATsT 16% 2% 20% 3% ND-8662 1537 AUCUUCGCCUGCCGCUUCATsT 1538 UGAAGCGGCAGGCGAAGAUTsT 19% 2% 25% 4% ND-8663 1539 UUCGCCUGCCGCUUCAACCTsT 1540 GGUUGAAGCGGCAGGCGAATsT 90% 4% 97% 10% ND-8664 1541 CACCCUCAAUCCCUACAGGTsT 1542 CCUGUAGGGAUUGAGGGUGTsT 19% 2% 25% 3% ND-8665 1543 AGAACAAAUCGGACUGCUUTsT 1544 AAGCAGUCCGAUUUGUUCUTsT 13% 1% 22% 2% ND-8666 1545 GAACAAAUCGGACUGCUUCTsT 1546 GAAGCAGUCCGAUUUGUUCTsT 11% 2% 18% 2% ND-8667 1547 CGGACUGCUUCUACCAGACTsT 1548 GUCUGGUAGAAGCAGUCCGTsT 13% 1% 16% 2% ND-8668 1549 AGCCUCAACAUCAACCUCATsT 1550 UGAGGUUGAUGUUGAGGCUTsT 17% 4% 21% 3% ND-8669 1551 GCCUCAACAUCAACCUCAATsT 1552 UUGAGGUUGAUGUUGAGGCTsT 13% 1% 21% 3% ND-8670 1553 GUCAGCCUCAACAUCAACCTsT 1554 GGUUGAUGUUGAGGCUGACTsT 43% 11% 27% 3% ND-8671 1555 UCAGCCUCAACAUCAACCUTsT 1556 AGGUUGAUGUUGAGGCUGATsT 90% 17% 53% 13% ND-8672 1557 CAGCCUCAACAUCAACCUCTsT 1558 GAGGUUGAUGUUGAGGCUGTsT 17% 3% 11% 3% ND-8673 1559 GGAGCUGGACCGCAUCACATsT 1560 UGUGAUGCGGUCCAGCUCCTsT 25% 3% 18% 3% ND-8674 1561 GUACCGCUUCCACUACAUCTsT 1562 GAUGUAGUGGAAGCGGUACTsT 21% 4% 16% 4% ND-8675 1563 CCGCUUCCACUACAUCAACTsT 1564 GUUGAUGUAGUGGAAGCGGTsT 25% 4% 19% 3% ND-8676 1565 CGCUUCCACUACAUCAACATsT 1566 UGUUGAUGUAGUGGAAGCGTsT 16% 3% 14% 1% ND-8677 1567 UUCCACUACAUCAACAUCCTsT 1568 GGAUGUUGAUGUAGUGGAATsT 110% 19% 97% 9% ND-8678 1569 UGGGCAACUUCAUCUUCGCTsT 1570 GCGAAGAUGAAGUUGCCCATsT 50% 8% 40% 5% ND-8679 1571 GCAACUUCAUCUUCGCCUGTsT 1572 CAGGCGAAGAUGAAGUUGCTsT 19% 3% 17% 2% ND-8680 1573 CAACUUCAUCUUCGCCUGCTsT 1574 GCAGGCGAAGAUGAAGUUGTsT 25% 2% 23% 2% ND-8681 1575 AACUUCAUCUUCGCCUGCCTsT 1576 GGCAGGCGAAGAUGAAGUUTsT 104% 7% 85% 10% ND-86B2 1577 ACUUCAUCUUCGCCUGCCGTsT 1578 CGGCAGGCGAAGAUGAAGUTsT 91% 8% 63% 9% ND-8683 1579 CUUCAUCUUCGCCUGCCGCTsT 1580 GCGGCAGGCGAAGAUGAAGTsT 88% 6% 58% 6% ND-3684 1581 UCAUCUUCGCCUGCCGCUUTsT 1582 AAGCGGCAGGCGAAGAUGATsT 76% 3% 64% 4% ND-8685 1583 CAUCUUCGCCUGCCGCUUCTsT 1584 GAAGCGGCAGGCGAAGAUGTsT 15% 1% 18% 3% ND-8686 1585 UCUUCGCCUGCCGCUUCAATsT 1586 UUGAAGCGGCAGGCGAAGATsT 109% 22% 31% 3% ND-8687 1587 CGCCUGCCGCUUCAACCAGTsT 1588 CUGGUUGAAGCGGCAGGCGTsT 90% 21% 49% 2% ND-8688 1589 GCCUGCCGCUUCAACCAGGTsT 1590 CCUGGUUGAAGCGGCAGGCTsT 43% 9% 24% 7% ND-8689 1591 AUUACUCUCACUUCCACCATsT 1592 UGGUGGAAGUGAGAGUAAUTsT 27% 4% 19% 2% ND-8690 1593 UUACUCUCACUUCCACCACTsT 1594 GUGGUGGAAGUGAGAGUAATsT 109% 7% 85% 8% ND-8691 1595 ACUCUCACUUCCACCACCCTsT 1596 GGGUGGUGGAAGUGAGAGUTsT 93% 11% 87% 12% ND-8692 1597 UCUGCACCCUCAAUCCCUATsT 1598 UAGGGAUUGAGGGUGCAGATsT 31% 12% 17% 2% ND-8693 1599 CUGCACCCUCAAUCCCUACTsT 1600 GUAGGGAUUGAGGGUGCAGTsT 41% 25% 31% 4% ND-8694 1601 UGCACCCUCAAUCCCUACATsT 1602 UGUAGGGAUUGAGGGUGCATsT 75% 25% 43% 3% ND-8695 1603 ACCCUCAAUCCCUACAGGUTsT 1604 ACCUGUAGGGAUUGAGGGUTsT 65% 26% 25% 5% ND-8696 1605 CCCUCAAUCCCUACAGGUATsT 1606 UACCUGUAGGGAUUGAGGGTsT 18% 2% 13% 1% ND-8697 1607 CCUCAAUCCCUACAGGUACTsT 1608 GUACCUGUAGGGAUUGAGGTsT 16% 4% 13% 2% ND-8698 1609 AACGAGAACAAAUCGGACUTsT 1610 AGUCCGAUUUGUUCUGGUUTsT 40% 2% 30% 2% ND-8699 1611 AACAAAUCGGACUGCUUCUTsT 1612 AGAAGCAGUCCGAUUUGUUTsT 56% 4% 45% 3% ND-8700 1613 ACAAAUCGGACUGCUUCUATsT 1614 UAGAAGCAGUCCGAUUUGUTsT 18% 3% 12% 1% ND-8701 1615 CAAAUCGGACUGCUUCUACTsT 1616 GUAGAAGCAGUCCGAUUUGTsT 15% 2% 15% 4% ND-8702 1617 GCACCCUCAAUCCCUACAGTsT 1618 CUGUAGGGAUUGAGGGUGCTsT 53% 4% 46% 20% ND-8703 1619 CCUCAACAUCAACCUCAACTsT 1620 GUUGAGGUUGAUGUUGAGGTsT 25% 6% 26% 9% ND-B704 1621 CUCAACAUCAACCUCAACUTsT 1622 AGUUGAGGUUGAUGUUGAGTsT 30% 8% 37% 26% ND-8705 1623 UCAACAUCAACCUCAACUCTsT 1624 GAGUUGAGGUUGAUGUUGATsT 55% 1% 50% 10% ND-8706 1625 UACCGCUUCCACUACAUCATsT 1626 UGAUGUAGUGGAAGCGGUATsT 36% 7% 31% 7% ND-8707 1627 ACCGCUUCCACUACAUCAATsT 1628 UUGAUGUAGUGGAAGCGGUTsT 23% 5% 27% 10% ND-8708 1629 GCUUCCACUACAUCAACAUTsT 1630 AUGUUGAUGUAGUGGAAGCTsT 16% 4% 24% 12% ND-8709 1631 CUUCCACUACAUCAACAUCTsT 1632 GAUGUUGAUGUAGUGGAAGTsT 62% 3% 74% 27% ND-8710 1633 UCCACUACAUCAACAUCCUTsT 1634 AGGAUGUUGAUGUAGUGGATsT 45% 8% 41% 1% ND-8711 1635 CCACUACAUCAACAUCCUGTsT 1636 CAGGAUGUUGAUGUAGUGGTsT 23% 4% 27% 10% ND-8712 1637 CUGGGCAACUUCAUCUUCGTsT 1638 CGAAGAUGAAGUUGCCCAGTsT 34% 4% 26% 5% ND-8713 1639 GGCAACUUCAUCUUCGCCUTsT 1640 AGGCGAAGAUGAAGUUGCCTsT 30% 3% 23% 2% ND-8714 1641 UUCAUCUUCGCCUGCCGCUTsT 1642 AGCGGGAGGCGAAGAUGAATsT 90% 14% 85% 14% ND-8715 1643 UCGCCUGCCGCUUCAACCATsT 1644 UGGUUGAAGCGGCAGGCGATsT 23% 2% 20% 4% TABLE 2A Concentration at 50% inhibition (IC50) for exemplary iRNA agents of Table 1A IC50 [nM] IC50 [nM] Duplex 1st DRC in 2nd DRC in ID H441 H441 ND8294 0.1949 0.0468 ND8295 0.1011 0.0458 ND8299 0.5986 0.5638 ND8302 0.0144 0.0134 ND8313 0.0315 0.0124 ND8320 0.0796 0.0078 ND8331 0.0213 0.0158 ND8332 0.0205 0.0089 ND8343 0.0523 0.0293 ND8348 0.0156 0.0182 ND8356 0.0241 0.0099 ND8357 0.0054 0.0032 ND8363 0.1186 0.0337 ND8368 0.0487 0.1209 ND8371 0.0811 0.0911 ND8372 0.0584 0.0425 ND8373 0.0066 0.0165 ND8375 0.1176 0.1187 ND8380 0.6817 0.5747 ND8381 0.0037 0.0041 ND8383 0.0275 0.1257 ND8384 0.0357 0.0082 ND8391 0.0260 0.0349 ND8392 0.3831 0.4775 ND8396 0.0023 0.0052 ND8403 0.0808 0.0759 TABLE 2B Concentration at 50% inhibition (IC50) and for exemplary iRNA agents of Table 1D.", "IC50 [nM] IC50 [nM] Duplex 1st DRC in 2nd DRC in ID H441 H441 ND8441 0.6738 0.8080 ND8443 0.0346 0.0263 ND8449 0.0120 0.0067 ND8450 0.0257 0.0106 ND8451 0.1320 0.0931 ND8453 0.0079 0.0033 ND8489 0.1640 0.1593 ND8496 0.0387 0.0185 TABLE 2C % Activity of the exemplary RNAi towards inhibition of alpha- ENaC gene expression in the assays described in Example 3 % alpha-ENaC Cynomolgous expression in primary alpha-ENaC expres- HBEC (% of control) sion (% of control) Duplex identifier 50 nM siRNA 45 nM siRNA Untransfected 77.2 n/a Non-targetting Control 100 93.3 Negative Control n/a 100 (Non-cyno alpha-ENaC) ND8449 ND-8302 30.2 57 ND-8332 24.7 54.3 ND-8348 40.1 56.2 ND-8356 36.6 55.8 ND-8357 29.6 50.4 ND-8373 30.4 53.8 ND-8381 32.5 40.4 ND-8396 34.1 46.3 ND-8450 45.9 78.9 ND-8453 30.1 55.3" ] ]
Patent_15874396
[ [ "CLEANING LIQUID", "The present invention relates to a cleaning liquid, in particular a cleaning liquid for cleaning surfaces and/or for sanitising water." ], [ "1-11.", "(canceled) 12.An aqueous mixture comprising: water and a cleaning liquid, the cleaning liquid comprising: benzalkonium chloride, didecyl dimethyl ammonium chloride, poly hexamethylene biguanide hydrochloride, bronopol, and p-chloro-m-cresol.", "13.The aqueous mixture of claim 12, wherein the water is tap water, potable water, distilled water, dirty water, water containing soil, water containing effluent, water containing pathogens, water containing waste, waste water and/or brackish water.", "14.The aqueous mixture of claim 12, wherein the aqueous mixture has a ratio of water by volume to cleaning liquid of from 99% water to 1% cleaning liquid to 1% water to 99% cleaning liquid, or any intermediate value.", "15.The aqueous mixture of claim 14, wherein the aqueous mixture has a ratio of water by volume to cleaning liquid of 99%, 95%, 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55%, 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10%, 5%, 4%, 3%, 2%, 1.5%, 1%, 0.9%, 0.8%, 0.7%, 0.6%, 0.5%, 0.4%, 0.3%, 0.2%, 0.1% or 0.05% water to cleaning liquid.", "16.The aqueous mixture of claim 12, wherein the aqueous mixture has a ratio of water by volume to cleaning liquid of from 99% water to 1% cleaning liquid.", "17-23.", "(canceled) 24.The aqueous mixture of claim 12, wherein the cleaning liquid further comprises an alkylene glycol.", "25.The aqueous mixture of claim 24, wherein the alkylene glycol is ethylene glycol, propylene glycol, diethylene glycol, block copolymers of ethyleneoxide and propyleneoxide, any other alkylene glycol formed from combining alkylene oxides and/or any combination of alkylene glycols.", "26.The aqueous mixture of claim 24, wherein the alkylene glycol comprises ethylene glycol.", "27.The aqueous mixture of claim 12, wherein the cleaning liquid does not include one or more siloxanes.", "28.The aqueous mixture of claim 12, wherein the cleaning liquid comprises 0.5-2.5 weight % alkylene glycol.", "29.The aqueous mixture of claim 12, wherein the cleaning liquid comprises 0.01-0.1 weight % p-chloro-m-cresol.", "30.The aqueous mixture of claim 12, wherein the cleaning liquid comprises, in weight %: 0.5-10 benzalkonium chloride, 0.5-10 didecyl dimethyl ammonium chloride, 0.5-10 poly hexamethylene biguanide hydrochloride, 0.3-5 bronopol, and 0.01-0.1 p-chloro-m-cresol.", "31.The aqueous mixture of claim 12, wherein the cleaning liquid comprises: benzalkonium chloride; didecyl dimethyl ammonium chloride; poly hexamethylene biguanide hydrochloride; bronopol; p-chloro-m-cresol; ethanol; and, ethylene glycol.", "32.The aqueous mixture of claim 12, wherein the cleaning liquid comprises in weight %: 0.15 benzalkonium chloride; 0.15 didecyl dimethyl ammonium chloride; 0.165 poly hexamethylene biguanide hydrochloride; 0.045 bronopol; 0.002 p-chloro-m-cresol; 0.245 ethanol; and 0.05 ethylene glycol.", "33.The aqueous mixture of claim 12, wherein the aqueous mixture has a water content by volume of at least 90%." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Surfaces often come into contact with, provide an environment for and provide a breeding ground for, potentially harmful pathogens.", "Non-limiting examples of surfaces include floors, table tops, and kitchen side boards, having any angle relative to ground level and of any shape, i.e.", "reference to surfaces is not limited to flat surfaces.", "A potentially harmful pathogen is any organism which can cause disease.", "Non-limiting examples of potentially harmful pathogens include bacteria, fungi, viruses, allergens, moulds and yeasts.", "It is common to clean surfaces with agents which act to mitigate and/or destroy potentially harmful pathogens.", "The cleaning of surfaces in this way is beneficial to human and animal health, so as to prevent the spread of disease and mitigate the chances of a subject or subjects contracting a disease by coming into contact with potentially harmful pathogens.", "One environment where it is particularly beneficial to clean surfaces with agents which act to mitigate and/or destroy potentially harmful pathogens is a veterinary environment, e.g.", "in a veterinary operating theatre.", "Another environment where it is particularly beneficial to clean surfaces with agents which act to mitigate and/or destroy potentially harmful pathogens is a hospital environment, e.g.", "in a hospital operating theatre.", "Another environment where it is particularly beneficial to clean surfaces with agents which act to mitigate and/or destroy potentially harmful pathogens is in a public amenity, e.g.", "the floor around a swimming pool.", "There are many other environments where it is particularly beneficial to clean surfaces with agents which act to mitigate and/or destroy potentially harmful pathogens including, but not limited to, general household cleaning, hospitality venues, hotels, nursing homes, cruise ships and industrial food processing equipment.", "Surfaces in veterinary operating theatres, hospitals, public amenities and other areas where people or animals could come into contact with harmful pathogens, should be cleaned regularly to prevent the build up of potentially harmful pathogens.", "Cleaning liquids used to clean surfaces include bleach solutions, solutions of washing up liquid, alcohol based disinfectants and general disinfectant liquid.", "One non-limiting example of a disinfectant liquid is Dettol™, as currently sold in the UK by Reckitt Benckiser™.", "In using cleaning liquids, cleaning liquid is often transferred from storage, e.g.", "a bucket or a bowl, or other container, to a surface potentially contaminated with one or more pathogens.", "In cleaning surfaces and/or water supplies, in particular in cleaning surfaces in hospitals, it is preferable for the anti-pathogen agent to be active in the presence of organic matter for a number of minutes, for example, up to 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 70, 80 and 90 minutes, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 and 24 hours, and all other times in between.", "It is particularly preferable for the anti-pathogen agent to be active for at least 60 minutes up to 24 hours in a hospital environment so that a cleaner may continue to use a cleaning solution containing a cleaning liquid for a suitable amount of time, without having to repeatedly replenish the cleaning solution, for example because the activity of the anti-pathogen agent has decreased.", "Known floor cleaning formulations include bleach solutions, these are effective at destroying pathogens on surfaces.", "However, bleach can be harmful to humans and animals in its own right.", "Solutions of washing up liquid have relatively weak anti-pathogen activity.", "Alcohol based disinfectants are used, but the alcohol, which has anti-pathogen activity, is relatively volatile so it evaporates off and has a relatively short anti-pathogen activity time.", "It is preferable for cleaning liquids, specifically those used in a hospital environment, to have a relatively long (around 1 hour) anti-pathogen activity time so that after, for example, a floor has been mopped the anti-pathogen activity continues for long enough that pathogens do not have a chance to settle and/or grow in between cleaning cycles.", "Disinfectant liquid, e.g.", "Dettol™, is effective in its anti-pathogen activity, but many pathogens build up resistance to long-used disinfectants.", "Cleaning liquids are also used in water supplies, e.g.", "in swimming pools, hot tubs (for example Jaccuzzis™) and spas where persons come into contact with communal water.", "Water supplies in swimming pools are often treated by chlorination.", "Water supplies in hot tubs are often treated by ozonation and/or by the introduction of halogens, e.g.", "bromine, into the water supply.", "In the case of a particular pathogen, namely, Cryptosporidium parvum , contamination of swimming pool and recreational waters is a serious problem.", "Once the waters become contaminated, it is easy for the organism to be transmitted into humans and infection can occur from as little as 132 oocysts (DuPont et al., (1995), The Infectivity of Cryptosporidium parvum in Healthy Volunteers, 332(13): 855-859).", "The current treatment of these waters with chlorine is ineffective to eliminate this organism, as previous studies have shown that treatment with 4 ppm chlorine at pH 7 for 25 hours resulted in no decrease in cell viability as seen by the DAPI/PI assay, and only a 40% reduction in cell viability when using the excystation assay (Widmer, (2002), Molecular mechanisms of chemical inactivation of Cryptosporidium oocysts and Giardia cysts, AWWA Research Foundation).", "There is a need for a new cleaning liquid which can be applied to surfaces, and used in water treatment, which is effective in mitigating pathogen counts and has limited, or no, harmful side effects on humans and animals." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>According to a first aspect of the present invention, there is provided a cleaning liquid for inhibiting pathogens, the cleaning liquid comprising: benzalkonium chloride, didecyl dimethyl ammonium chloride, poly hexamethylene biguanide hydrochloride, bronopol, and p-chloro-m-cresol.", "Preferably, further comprising an alkylene glycol.", "Further preferably, wherein the alkylene glycol is ethylene glycol, propylene glycol, diethylene glycol, block copolymers of ethyleneoxide and propyleneoxide, any other alkylene glycol formed from combining alkylene oxides and/or any combination of alkylene glycols.", "Advantageously, wherein the alkylene glycol comprises or consists of ethylene glycol.", "Preferably, wherein the cleaning liquid does not include one or more siloxanes.", "Further preferably, wherein the cleaning liquid comprises 0.5-2.5 weight % alkylene glycol.", "Advantageously, wherein the cleaning liquid comprises 0.01-0.1 weight % p-chloro-m-cresol.", "Preferably, wherein the cleaning liquid comprises, in weight %: 0.5-10 benzalkonium chloride, 0.5-10 didecyl dimethyl ammonium chloride, 0.5-10 poly hexamethylene biguanide hydrochloride, 0.3-5 bronopol, and 0.01-0.1 p-chloro-m-cresol.", "Further preferably, wherein the cleaning liquid comprises, or consists of: benzalkonium chloride; didecyl dimethyl ammonium chloride; poly hexamethylene biguanide hydrochloride; bronopol; p-chloro-m-cresol; ethanol; and, ethylene glycol.", "Advantageously, wherein the cleaning liquid comprises, or consists of, in weight %: 0.5-10 benzalkonium chloride; 0.5-10 didecyl dimethyl ammonium chloride; 0.5-10 poly hexamethylene biguanide hydrochloride; 0.3-5 bronopol; 0.01-0.1 p-chloro-m-cresol; 3-10 ethanol; and, 0.5-2.5 ethylene glycol; and/or any intermediate value of each range for each component; the balance being water.", "Preferably, wherein the cleaning liquid comprises, or consists of, in weight %: 3 benzalkonium chloride; 3 didecyl dimethyl ammonium chloride; 3.3 poly hexamethylene biguanide hydrochloride; 0.9 bronopol; 0.04 p-chloro-m-cresol; 4.9 ethanol; and, 1.0 ethylene glycol; the balance being water.", "According to another aspect of the present invention, there is provided an aqueous mixture comprising: water and a cleaning liquid according to any one of the above.", "Preferably, wherein the water is tap water, potable water, distilled water, dirty water, water containing soil, water containing effluent, water containing pathogens, water containing waste, waste water and/or brackish water.", "Further preferably, wherein the composition has a ratio of water by volume to cleaning liquid of from 99% water to 1% cleaning liquid to 1% water to 99% cleaning liquid, or any intermediate value.", "Advantageously, wherein the composition has a ratio of water by volume to cleaning liquid of 99%, 95%, 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55%, 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10%, 5%, 4%, 3%, 2%, 1.5%, 1%, 0.9%, 0.8%, 0.7%, 0.6%, 0.5%, 0.4%, 0.3%, 0.2%, 0.1% or 0.05% water to cleaning liquid.", "Preferably, wherein the composition has a ratio of water by volume to cleaning liquid of from 99% water to 1% cleaning liquid.", "According to another aspect of the present invention, there is provided a method of cleaning a surface, comprising: providing a cleaning liquid or an aqueous mixture according to any one of the above; and, applying the mixture to a surface.", "According to another aspect of the present invention, there is provided a method of sanitising water, comprising: providing a cleaning liquid or an aqueous mixture according to any one of the above; and, contacting the cleaning liquid or aqueous mixture with water to be sanitised.", "According to another aspect of the present invention, there is provided a method of preparing a cleaning liquid according to any one of the above, comprising: providing the components according to any one of the above; and, mixing the ingredients in a mixer.", "According to another aspect of the present invention, there is provided a wipe for application to skin, the wipe comprising a cleaning liquid or an aqueous mixture according to any one of the above.", "According to another aspect of the present invention, there is provided the use of a cleaning liquid or an aqueous mixture of any one of the above, in any one of: cleaning a surface; sanitising a water supply; or disinfecting an area of skin.", "Preferably, the use in sanitising a water supply, wherein the cleaning liquid or aqueous mixture of any one of the above is used as a supplement, or in addition to, chlorine water treatment." ], [ "FIELD OF THE INVENTION The present invention relates to a cleaning liquid.", "More particularly, the present invention relates to a cleaning liquid for sanitising surfaces and sanitising water supplies.", "The present invention also relates to a method of forming a cleaning liquid.", "BACKGROUND OF THE INVENTION Surfaces often come into contact with, provide an environment for and provide a breeding ground for, potentially harmful pathogens.", "Non-limiting examples of surfaces include floors, table tops, and kitchen side boards, having any angle relative to ground level and of any shape, i.e.", "reference to surfaces is not limited to flat surfaces.", "A potentially harmful pathogen is any organism which can cause disease.", "Non-limiting examples of potentially harmful pathogens include bacteria, fungi, viruses, allergens, moulds and yeasts.", "It is common to clean surfaces with agents which act to mitigate and/or destroy potentially harmful pathogens.", "The cleaning of surfaces in this way is beneficial to human and animal health, so as to prevent the spread of disease and mitigate the chances of a subject or subjects contracting a disease by coming into contact with potentially harmful pathogens.", "One environment where it is particularly beneficial to clean surfaces with agents which act to mitigate and/or destroy potentially harmful pathogens is a veterinary environment, e.g.", "in a veterinary operating theatre.", "Another environment where it is particularly beneficial to clean surfaces with agents which act to mitigate and/or destroy potentially harmful pathogens is a hospital environment, e.g.", "in a hospital operating theatre.", "Another environment where it is particularly beneficial to clean surfaces with agents which act to mitigate and/or destroy potentially harmful pathogens is in a public amenity, e.g.", "the floor around a swimming pool.", "There are many other environments where it is particularly beneficial to clean surfaces with agents which act to mitigate and/or destroy potentially harmful pathogens including, but not limited to, general household cleaning, hospitality venues, hotels, nursing homes, cruise ships and industrial food processing equipment.", "Surfaces in veterinary operating theatres, hospitals, public amenities and other areas where people or animals could come into contact with harmful pathogens, should be cleaned regularly to prevent the build up of potentially harmful pathogens.", "Cleaning liquids used to clean surfaces include bleach solutions, solutions of washing up liquid, alcohol based disinfectants and general disinfectant liquid.", "One non-limiting example of a disinfectant liquid is Dettol™, as currently sold in the UK by Reckitt Benckiser™.", "In using cleaning liquids, cleaning liquid is often transferred from storage, e.g.", "a bucket or a bowl, or other container, to a surface potentially contaminated with one or more pathogens.", "In cleaning surfaces and/or water supplies, in particular in cleaning surfaces in hospitals, it is preferable for the anti-pathogen agent to be active in the presence of organic matter for a number of minutes, for example, up to 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 70, 80 and 90 minutes, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 and 24 hours, and all other times in between.", "It is particularly preferable for the anti-pathogen agent to be active for at least 60 minutes up to 24 hours in a hospital environment so that a cleaner may continue to use a cleaning solution containing a cleaning liquid for a suitable amount of time, without having to repeatedly replenish the cleaning solution, for example because the activity of the anti-pathogen agent has decreased.", "Known floor cleaning formulations include bleach solutions, these are effective at destroying pathogens on surfaces.", "However, bleach can be harmful to humans and animals in its own right.", "Solutions of washing up liquid have relatively weak anti-pathogen activity.", "Alcohol based disinfectants are used, but the alcohol, which has anti-pathogen activity, is relatively volatile so it evaporates off and has a relatively short anti-pathogen activity time.", "It is preferable for cleaning liquids, specifically those used in a hospital environment, to have a relatively long (around 1 hour) anti-pathogen activity time so that after, for example, a floor has been mopped the anti-pathogen activity continues for long enough that pathogens do not have a chance to settle and/or grow in between cleaning cycles.", "Disinfectant liquid, e.g.", "Dettol™, is effective in its anti-pathogen activity, but many pathogens build up resistance to long-used disinfectants.", "Cleaning liquids are also used in water supplies, e.g.", "in swimming pools, hot tubs (for example Jaccuzzis™) and spas where persons come into contact with communal water.", "Water supplies in swimming pools are often treated by chlorination.", "Water supplies in hot tubs are often treated by ozonation and/or by the introduction of halogens, e.g.", "bromine, into the water supply.", "In the case of a particular pathogen, namely, Cryptosporidium parvum, contamination of swimming pool and recreational waters is a serious problem.", "Once the waters become contaminated, it is easy for the organism to be transmitted into humans and infection can occur from as little as 132 oocysts (DuPont et al., (1995), The Infectivity of Cryptosporidium parvum in Healthy Volunteers, 332(13): 855-859).", "The current treatment of these waters with chlorine is ineffective to eliminate this organism, as previous studies have shown that treatment with 4 ppm chlorine at pH 7 for 25 hours resulted in no decrease in cell viability as seen by the DAPI/PI assay, and only a 40% reduction in cell viability when using the excystation assay (Widmer, (2002), Molecular mechanisms of chemical inactivation of Cryptosporidium oocysts and Giardia cysts, AWWA Research Foundation).", "There is a need for a new cleaning liquid which can be applied to surfaces, and used in water treatment, which is effective in mitigating pathogen counts and has limited, or no, harmful side effects on humans and animals.", "SUMMARY OF THE INVENTION According to a first aspect of the present invention, there is provided a cleaning liquid for inhibiting pathogens, the cleaning liquid comprising: benzalkonium chloride, didecyl dimethyl ammonium chloride, poly hexamethylene biguanide hydrochloride, bronopol, and p-chloro-m-cresol.", "Preferably, further comprising an alkylene glycol.", "Further preferably, wherein the alkylene glycol is ethylene glycol, propylene glycol, diethylene glycol, block copolymers of ethyleneoxide and propyleneoxide, any other alkylene glycol formed from combining alkylene oxides and/or any combination of alkylene glycols.", "Advantageously, wherein the alkylene glycol comprises or consists of ethylene glycol.", "Preferably, wherein the cleaning liquid does not include one or more siloxanes.", "Further preferably, wherein the cleaning liquid comprises 0.5-2.5 weight % alkylene glycol.", "Advantageously, wherein the cleaning liquid comprises 0.01-0.1 weight % p-chloro-m-cresol.", "Preferably, wherein the cleaning liquid comprises, in weight %: 0.5-10 benzalkonium chloride, 0.5-10 didecyl dimethyl ammonium chloride, 0.5-10 poly hexamethylene biguanide hydrochloride, 0.3-5 bronopol, and 0.01-0.1 p-chloro-m-cresol.", "Further preferably, wherein the cleaning liquid comprises, or consists of: benzalkonium chloride; didecyl dimethyl ammonium chloride; poly hexamethylene biguanide hydrochloride; bronopol; p-chloro-m-cresol; ethanol; and, ethylene glycol.", "Advantageously, wherein the cleaning liquid comprises, or consists of, in weight %: 0.5-10 benzalkonium chloride; 0.5-10 didecyl dimethyl ammonium chloride; 0.5-10 poly hexamethylene biguanide hydrochloride; 0.3-5 bronopol; 0.01-0.1 p-chloro-m-cresol; 3-10 ethanol; and, 0.5-2.5 ethylene glycol; and/or any intermediate value of each range for each component; the balance being water.", "Preferably, wherein the cleaning liquid comprises, or consists of, in weight %: 3 benzalkonium chloride; 3 didecyl dimethyl ammonium chloride; 3.3 poly hexamethylene biguanide hydrochloride; 0.9 bronopol; 0.04 p-chloro-m-cresol; 4.9 ethanol; and, 1.0 ethylene glycol; the balance being water.", "According to another aspect of the present invention, there is provided an aqueous mixture comprising: water and a cleaning liquid according to any one of the above.", "Preferably, wherein the water is tap water, potable water, distilled water, dirty water, water containing soil, water containing effluent, water containing pathogens, water containing waste, waste water and/or brackish water.", "Further preferably, wherein the composition has a ratio of water by volume to cleaning liquid of from 99% water to 1% cleaning liquid to 1% water to 99% cleaning liquid, or any intermediate value.", "Advantageously, wherein the composition has a ratio of water by volume to cleaning liquid of 99%, 95%, 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55%, 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10%, 5%, 4%, 3%, 2%, 1.5%, 1%, 0.9%, 0.8%, 0.7%, 0.6%, 0.5%, 0.4%, 0.3%, 0.2%, 0.1% or 0.05% water to cleaning liquid.", "Preferably, wherein the composition has a ratio of water by volume to cleaning liquid of from 99% water to 1% cleaning liquid.", "According to another aspect of the present invention, there is provided a method of cleaning a surface, comprising: providing a cleaning liquid or an aqueous mixture according to any one of the above; and, applying the mixture to a surface.", "According to another aspect of the present invention, there is provided a method of sanitising water, comprising: providing a cleaning liquid or an aqueous mixture according to any one of the above; and, contacting the cleaning liquid or aqueous mixture with water to be sanitised.", "According to another aspect of the present invention, there is provided a method of preparing a cleaning liquid according to any one of the above, comprising: providing the components according to any one of the above; and, mixing the ingredients in a mixer.", "According to another aspect of the present invention, there is provided a wipe for application to skin, the wipe comprising a cleaning liquid or an aqueous mixture according to any one of the above.", "According to another aspect of the present invention, there is provided the use of a cleaning liquid or an aqueous mixture of any one of the above, in any one of: cleaning a surface; sanitising a water supply; or disinfecting an area of skin.", "Preferably, the use in sanitising a water supply, wherein the cleaning liquid or aqueous mixture of any one of the above is used as a supplement, or in addition to, chlorine water treatment.", "BRIEF DESCRIPTION OF DRAWINGS FIG.", "1: Shows the average culturable bacterial count after treatment with composition A.", "FIG.", "2: Shows the average culturable bacterial count after treatment with composition.", "FIG.", "3: Shows the total numbers of dead and live E. coli cells determined using the cell elongation assay.", "FIG.", "4: Shows the percentage survival of C. parvum oocysts after 24 h incubation with a range of concentrations of biocide SQ53 (grey bars).", "FIG.", "5: Bacterial culturability of K. pneumoniae after treatment with various concentrations of biocide SQ53.DETAILED DESCRIPTION Composition A Some of the components of cleaning liquids of the present invention, together with their sources, are set out below.", "Composition A, also referred to as SQ53 in this specification (sometimes referred to as JVS 90 or JVS Formula 90 by the inventor, but not in this specification), is a non-limiting example of a composition according to the present invention: Composition A Amount Amount Marketed Generic CAS (weight %) (weight %) name name number in neat in 1:19 v/v Acticide Benzalkonium 63449-41-2 3 0.15 BAC50M chloride Acticide Didecyl 7173-51-5 3 0.15 DDQ50 Dimethyl Ammonium Chloride Acticide Poly 27083-27-8 3.3 0.165 PHB20 Hexamethylene Biguanide Hydrochloride Acticide L Bronopol 52-51-7 0.9 0.045 Acticide P-chloro-m- 59-50-7 0.04 0.002 PCMC cresol Ethanol 64-17-5 4.9 0.245 Ethylene glycol 107-21-1 1.0 0.05 Aqua 83.86 99.193 Composition A is a composition according to a preferred embodiment of the present invention.", "The names of the ingredients are listed, along with their CAS (Chemical Abstract Service) number.", "The CAS number has been given because the CAS registry is a standard reference for persons looking to classify chemical compounds which are known in the scientific literature.", "In all of the compositions, the amount of each ingredient is provided in weight % (also referred to in this specification as wt % or % w/w).", "The column “amount .", ".", ".", "in neat” shows the neat composition.", "The column “amount .", ".", ".", "in 1:19 v/v” shows the amount of each component in a 1:19 v/v neat composition-water solution.", "The indication “v/v” indicates the ratio is by volume.", "Components of Composition A Benzalkonium chloride is a mixture of alkylbenzyldimethylammonium chlorides of various even-numbered alkyl chain lengths.", "Benzalkonium chloride may act as inter alia a biocide, a cationic surfactant and a phase transfer agent.", "A non-limiting example of a batch size for composition A is 10 kg.", "Didecyl Dimethyl Ammonium Chloride is a compound which acts as inter alia an antiseptic and/or a disinfectant, i.e.", "a biocide.", "Poly Hexamethylene Biguanide Hydrochloride is a polymer which acts as inter alia a disinfectant and/or an antiseptic, i.e.", "a biocide.", "Bronopol is a compound which acts as inter alia an antimicrobial, i.e.", "a biocide.", "Bronopol is commonly used as a preservative in consumer products, e.g.", "in cosmetics.", "P-chloro-m-cresol (4-chloro-3-methylphenol) is a compound which acts as inter alia an antiseptic and a preservative, i.e.", "a biocide.", "P-chloro-m-cresol is often used in handwash.", "Ethanol is a colourless liquid often used as a solvent.", "Ethylene glycol is a compound commonly used in antifreeze and as a precursor to some polymers.", "In other embodiments, ethylene glycol may be substituted, in whole or in part, with other alkylene glycols, for example: propylene glycol, diethylene glycol, block copolymers of ethyleneoxide and propyleneoxide (e.g.", "different types of Pluronic™ as sold by BASF™), any other alkylene glycol formed from combining alkylene oxides and/or any combination of alkylene glycols.", "Manufacturing Protocol for Composition A The following is a protocol for forming a cleaning liquid according to composition A shown above.", "The amounts of each ingredient used at each step are shown above, i.e.", "they are not specified in the method below.", "In one exemplary embodiment, all of the ingredients of composition A are mixed in any order, in the amounts specified in the tables, to result in a formulation according to the present invention.", "In another exemplary embodiment, composition A is prepared as follows: i.", "Select a clean manufacturing vessel, e.g.", "a stainless steel mixing vessel with a propeller shaft.", "ii.", "Ensure any inlets or outlets from the manufacturing vessel are clean.", "iii.", "Measure out all raw materials, as required for the composition.", "iv.", "Optionally, add water for the desired final dilution.", "v. Introduce the following components, preferably in order: (1) Acticide PCMC; (2) Acticide L; (3) Acticide BAC 50; (4) Acticide DDQ 50; (5) Acticide PHB20, mixing the components either continuously or after each introduction.", "vi.", "Separately add in ethanol, followed by ethylene glycol, mixing continuously at 25° C. and 100 kPa, and until all components are dissolved.", "vii.", "Optionally, add additional water to dilute the mixture to a desired degree.", "The composition is optionally filtered with a 25 micron filter.", "Ranges for each of the ingredients in composition A are provided in the table below.", "All compositions falling within these boundaries are expected to have the same effects.", "The ranges are provided to show the ranges which have been tested.", "The ranges each include each intermediate value, e.g.", "10-20 includes 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20, and each further intermediate value.", "Composition A Ranges (Example): Ranges for Composition composition A Amount A Amount Marketed Generic CAS (weight %) (weight %) name name number in neat in neat Acticide Benzalkonium 63449-41-2 3 0.5-10 BAC50M chloride Acticide Didecyl 7173-51-5 3 0.5-10 DDQ50 Dimethyl Ammonium Chloride Acticide Poly 27083-27-8 3.3 0.5-10 PHB20 Hexamethylene Biguanide Hydrochloride Acticide L Bronopol 52-51-7 0.9 0.3-5 Acticide P-chloro-m- 59-50-7 0.04 0.01-0.1 PCMC cresol Ethanol 64-17-5 4.9 3-10 Ethylene glycol 107-21-1 1.0 0.5-2.5 Aqua 83.86 52.40-94.69 Composition A, according to the present invention, is in compliance with Regulation (EC) 1907/2006 (REACh).", "In other words, the ingredients comply with the relevant EC law on safety in chemicals used in domestic environments.", "In an alternative embodiment, ethylene glycol can be replaced by a different alkylene glycol, e.g.", "mono propylene glycol.", "Other non-limiting examples of alkylene glycols include, but are not limited to, diethylene glycol, block copolymers of ethyleneoxide and propyleneoxide (e.g.", "different types of Pluronic™ as sold by BASF™), any other alkylene glycol formed from combining alkylene oxides and/or any combination of alkylene glycols.", "In use, the compositions of the present invention are mixed with water.", "Preferable mixing ratios with water for exemplary neat composition A is, in percentage terms (where 1% means 99 parts water to 1 part exemplary composition) 100%, 95%, 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55%, 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10%, 5%, 4%, 3%, 2%, 1.5%, 1%, 0.9%, 0.8%, 0.7%, 0.6%, 0.5%, 0.4%, 0.3%, 0.2%, 0.1% and 0.05%.", "An optional mixing ratio is 1%.", "Preferred embodiments include mixing neat composition with from 15 to 25 parts water (or any intermediate value) to one part neat composition A, by volume.", "In a particularly preferred embodiment, the neat composition is mixed with water in a one part neat composition to 19 parts water ratio (1:19 v/v), i.e.", "as shown in the right hand column of the table highlighting neat composition A.", "In another particularly preferred embodiment, the neat composition is mixed with water in a one part neat composition to 20 parts water ratio (1:20 v/v).", "In another particularly preferred embodiment, the neat composition is mixed with water in a one part neat composition to 60 parts water ratio (1:60 v/v).", "In use, the cleaning compositions of the present invention are applied to a surface by an applicator, for example, a mop, a sponge, a cloth, a towel or a glove.", "In use, the cleaning compositions of the present invention are stored in a receptacle, for example, a bucket, for application by an applicator.", "In a particularly preferred embodiment, the cleaning compositions of the present invention are stored in a bowl and applied to a surface by a cloth.", "In an alternative use, the cleaning compositions of the present invention are introduced into a water supply, e.g.", "a water supply for used in or to be introduced into a swimming pool.", "The water supply is contacted with the cleaning composition and then re-introduced into the swimming pool.", "In an alternative use, the cleaning compositions of the present invention are introduced onto the skin of a user, e.g.", "by way of a wipe or by spraying.", "Sanitising Surfaces Tests 1.A Variety of Pathogens A number of tests were carried out on composition A by D C Watson at Abbott Analytical, in New Ferry, UK, under a non-disclosure agreement.", "These tests were performed under different European standards, using 1:20 v/v dilution of the ‘neat’ version of composition A with water.", "These European standards are referred to as EN XX, where XX is the number assigned to the standard test by the relevant European Standardisation Organisation.", "The conclusions of Abbott Analytical were as follows: Composition A, when diluted to 1:20 v/v, passes the requirements of EN 1276 for bactericidal activity (Pseudomonas aeruginosa (NCIMB 10421), Escherichia coli (NCTC 10418), Staphylococcus aureus (NCTC 10788), Enterococcus hirae (NCIMB 8192)) in 5 minutes at 20° C. under dirty conditions against all of the reference organisms detailed.", "Composition A, when diluted to 1:20 v/v, passes the requirements of EN 1276 for bactericidal activity (Listeria monocytogenes (NCTF 11994), Salmonella typhimurium (NCTC 74), Methicillin-resistant Staphylococcus aureus (NCTC 12493)) in 5 minutes at 20° C. under dirty conditions against all of the reference organisms detailed.", "Composition A, when diluted to 1:20 v/v, passes the requirements of EN 13623 for bactericidal activity (Legionella pneumophila (NCTC 12821)) in 60 minutes at 30° C. against Legionella pneumophila.", "Composition A, when diluted to 1:20 v/v, passes the requirements of EN 1276 for bactericidal activity (Streptococcus dysgalactiae (NCIMB 702023), Streptococcus uberis (NCIMB 2038), Streptococcus suis (NCTC 10234), Streptococcus equi (NCTC 7912)) in 5 minutes at 20° C. under dirty conditions against all of the reference organisms detailed.", "Composition A, when diluted to 1:20 v/v, passes the requirements of EN 1650 for fungicidal activity (Aspergillus fumigatus (NCPF 7102)) in 15 minutes at 20° C. under dirty conditions against the reference organism detailed.", "Composition A, when diluted to 1:20 v/v, passes the requirements of EN 13704 for sporicidal activity (Clostridium difficile (NCTC 11209)) in 60 minutes at 20° C. under dirty conditions against the reference organism detailed.", "Composition A, when diluted to 1:20 v/v, passes the requirements of EN 13704 for sporicidal activity (Bacillus subtilis (NCIMB 8054), Bacillus cereus (ATCC 12826)) in 60 minutes at 20° C. under dirty conditions against both of the reference organisms detailed.", "Composition A, when diluted to 1:20 v/v, passes the requirements of EN 1500 for hygienic hand rubs when tested under the procedures described above.", "This shows the composition is suitable for mitigating the presence of pathogens on hands.", "In summary, composition A was found to have anti-bacterial, anti-fungicidal and anti-sporicidal effects.", "Composition A was also found to be suitable for use as a hand rub.", "2.Safety Furthermore, Reading Scientific Services Ltd, Reading, UK, carried out a safety evaluation of composition A, under a non-disclosure agreement.", "Reading Scientific Services Ltd concluded that composition A complies with the European Cosmetic Regulations and should not cause damage to health under normal and reasonably foreseeable use.", "3.Effect Against MRSA and E. coli Further tests were carried out on the effectiveness of the compositions of the present invention, namely, composition A detailed above.", "Tests were carried out by Dr Susanna Sherwin and Professor Bill Keevil, under a non-disclosure agreement, at the Environmental Healthcare Unit at the University of Southampton, UK.", "Their methods and results are set out below, with reference to the figures.", "Four experimental protocols were used: A. Culturable Cell Counts: Coating Surface with Bacteria, and then Adding Biocide Overnight cultures of MRSA (20 μl) were coated on 1 cm2 stainless steel coupons, and were allowed to dry; 20 μl aliquots of 5% (v/v) composition A was added to the coupons, and incubated at room temperature for 0 hours (control) or 2 hours.", "After incubation, cells were removed from coupons by vortexing in PBS with glass beads, and the resulting solution was diluted and plated on nutrient agar plates.", "After overnight incubation at 37° C., viable cells were counted.", "The colonies that grew on nutrient agar plates in this time period indicate the numbers of MRSA bacteria present in the original sample that were culturable in the lab, and are termed Colony Forming Units (CFUs).", "B. Culturable Cell Counts: Coating Surface with Biocide, and then Adding Bacteria Stainless steel coupons were submerged in composition A, removed and allowed to dry.", "Overnight cultures of MRSA (20 μl) were then added to the coupons, and the coupons were incubated at room temperature for 0 hours (control) or 2 hours.", "After incubation, cells were removed from coupons by vortexing in PBS with glass beads, and the resulting solution was diluted and plated on nutrient agar plates.", "After overnight incubation at 37° C., viable cells were counted.", "C. LIVE/Dead Microscopy Staining Experiments were conducted as mentioned above, and after incubation, LIVE/Dead fluorescent stain was added to the steel coupons, and incubated in the dark for 15 minutes.", "Epifluorescence microscopy was used to observe total numbers of cells (green) compared to dead cells with damaged cytoplasmic membranes (red).", "D. Cell Elongation Assay Using E. coli An 100 μl aliquot of an overnight E. coli culture (strain DH5-α) was added to either 900 μl PBS buffer, or 900 μl biocide (5% v/v).", "After 2 hours incubation, the cells were pelleted by centrifugation, and then resuspended in 1 ml PBS.", "This was then added to 9 ml 50% R2 broth.", "Pipemidic acid (final concentration 100 μg/ml) was added to the solution to stop live cell replication, causing live cells to become elongated.", "Samples were incubated for 18 hours at 22° C., before staining with SYTO9 fluorescent stain.", "A 1 ml aliquot of the sample was filtered through 0.2 μm polycarbonate filters, and examined using epifluorescent microscopy.", "Normal length (dead) cells were counted, as were elongated (live) cells.", "Results: A. and B. Culturable Cell Counts Composition A (in 1 part ‘neat’ to 19 parts water concentration (1:19 v/v)) resulted in bactericidal killing after two hours of contact time.", "However, the order in which the bacteria and biocide were added to the steel coupons proved to be crucial to the killing effect of the composition.", "If stainless steel coupons were pre-coated with MRSA, and the biocides were added subsequently, a 1-2 log killing effect was seen using culture methods (Table 1 and FIG.", "1).", "However, if a sterile coupon was coated in biocide before the MRSA was introduced to the system, no viable MRSA could be detected after 2 hours incubation with (Table 1 and FIG.", "2).", "TABLE 1 Numbers of viable cells cultured after overnight incubation.", "Culturable cells are measured as colony forming units (CFU).", "0 Hour Average 2 Hour Average cell number cell number % Conditions (CFU ml−1) (CFU ml−1) Survival MRSA Only 4.13E+06 3.47E+06 83.87 Precoated MRSA plus 6.67E+05 1.97E+04 2.96 SQ53 Precoated SQ53 plus 1.77E+06 0.00E+00 0.00 MRSA FIG.", "1 shows the average culturable bacterial count after treatment with composition A. MRSA was pre-coated onto steel coupons, and the biocide SQ53 was added.", "Each bar is an average of 6 replicates, with error bars indicating standard error of the replicates.", "FIG.", "2 shows the average culturable bacterial count after treatment with composition.", "SQ53 was pre-coated onto steel coupons, and MRSA was added.", "Each bar is an average of 6 replicates, with error bars indicating standard error of the replicates.", "FIGS.", "1 and 2 show that composition A has a strong effect against MRSA, under the test conditions specified.", "C. Total Cell Count Using BacLight LIVE/Dead Viability Staining In addition to culturing methods, treated cells were stained with fluorescent LIVE/Dead dyes so that the proportion of surviving cells could be enumerated using epifluorescence microscopy.", "However, whilst it was possible to collect fluorescent images of total bacterial cells using the LIVE/Dead stain, it was not possible to observe ‘dead’ cell fluorescent staining using the Propidium Iodide (PI) stain for compromised bacterial membranes.", "This may be due to the action of the composition A (i.e.", "SQ53), which is thought to engulf the bacterial cell, thus affecting uptake of larger molecules, such as the ‘dead’ stain PI.", "D. Cell Elongation Study Using E. coli An additional experiment was carried out in order to determine the efficacy of the biocides using microscopy.", "For this experiment only, a different bacterium, E. coli was used.", "After treatment with biocides, the cells were incubated with an antibiotic, Pipemidic acid.", "If live cells were present, they would begin to replicate, but be unable to physically separate, resulting in an elongated cell, easily visible under the microscope, whereas the dead cells remain the size of a single bacterium.", "An average of 50 fields of view per treatment were photographed, and using these results, the total live and dead cells per original sample can be calculated.", "Calculation of Numbers of Fields of View Per Filter One Field of View=11623.58 μm2 Filter membrane diameter=21000 μm Filter membrane area (π r2)=346360590.1 μm2 Numbers of Fields of View per filter=346360590.1/11623.58 =23963.702 fields of view Therefore the overall average total cell count per field of view was multiplied by this factor to get total cell count per filter, and thus total cell count per 1 ml sample (the data is shown in Table 2).", "By this method, it was possible to determine that composition A resulted in at least a 2 log kill, although in this assay, composition A seemed to result in complete killing of the E. coli cells (FIG.", "3).", "However, the composition had an adverse effect on the assay.", "Once the cells have been treated with the composition, they become much stickier than the control cells.", "This meant that we were unable to completely resuspend the treated cells prior to the cell elongation assay, which resulted in decreased numbers of cells we could count (Table 2).", "TABLE 2 Total numbers of dead and live E. coli cells determined by epifluorescence microscopy.", "Cells per ml were determined by calculating average cells per field of view from a total of 50 fields of view, and then calculating the number of cells per filter.", "Average Average number of number of dead cells elongated cells (cells ml−1) (cells ml−1) Control (E. coli in PBS) 1.31E+07 1.31E+06 SQ53 5.18E+06 0.00E+00 FIG.", "3 shows the total numbers of dead and live E. coli cells determined using the cell elongation assay.", "Bars indicate dead cell count, and live (elongated) cell counts as determined cell elongation assay, and error bars indicate standard error of the replicates.", "The cell elongation assay, carried out on E. coli, was able to show that composition A, when applied to a cell culture, results in complete cell death.", "Composition A was found to be more effective than known cleaning liquids, whilst at the same time not including components which are harmful to human or animal health.", "4.Comparative Tests Further tests were carried out by D C Watson at Abbott Analytical, in New Ferry, UK, under a non-disclosure agreement.", "These tests were performed under the same European standard, using 1:20 v/v dilution of the ‘neat’ version of composition A.", "As mentioned above, composition A passes the requirements of EN 1276 for bactericidal activity (Pseudomonas aeruginosa (NCIMB 10421), Escherichia coli (NCTC 10418), Staphylococcus aureus (NCTC 10788), Enterococcus hirae (NCIMB 8192)) in 5 minutes at 20° C. under dirty conditions against all of the reference organisms detailed.", "As a comparison, solutions of Acticide BAC5OM (Benzalkonium chloride), Acticide DDQ 50 (Didecyl Dimethyl Ammonium Chloride), Acticide PHB 20 (Poly Hexamethylene Biguanide Hydrochloride), Acticide L (Bronopol) and Acticide PCMC (P-chloro-m-cresol) were all tested individually under the same conditions.", "In these tests, the same relative amounts of ethanol, ethylene glycol and water, as in composition A, were present.", "Acticide BAC50M (Benzalkonium chloride) in the same concentration as in composition A, when diluted to 1:20 v/v, does not pass the requirements of EN 1276 for bactericidal activity (Pseudomonas aeruginosa (NCIMB 10421), Escherichia coli (NCTC 10418), Staphylococcus aureus (NCTC 10788), Enterococcus hirae (NCIMB 8192)) in 5 minutes at 20° C. under dirty conditions against all of the reference organisms detailed.", "Acticide DDQ50 (Didecyl Dimethyl Ammonium Chloride) in the same concentration as in composition A, when diluted to 1:20 v/v, does not pass the requirements of EN 1276 for bactericidal activity (Pseudomonas aeruginosa (NCIMB 10421), Escherichia coli (NCTC 10418), Staphylococcus aureus (NCTC 10788), Enterococcus hirae (NCIMB 8192)) in 5 minutes at 20° C. under dirty conditions against all of the reference organisms detailed.", "Acticide PHB20 (Poly Hexamethylene Biguanide Hydrochloride) in the same concentration as in composition A, when diluted to 1:20 v/v, does not pass the requirements of EN 1276 for bactericidal activity (Pseudomonas aeruginosa (NCIMB 10421), Escherichia coli (NCTC 10418), Staphylococcus aureus (NCTC 10788), Enterococcus hirae (NCIMB 8192)) in 5 minutes at 20° C. under dirty conditions against all of the reference organisms detailed.", "Acticide L (Bronopol) in the same concentration as in composition A, when diluted to 1:20 v/v, does not pass the requirements of EN 1276 for bactericidal activity (Pseudomonas aeruginosa (NCIMB 10421), Escherichia coli (NCTC 10418), Staphylococcus aureus (NCTC 10788), Enterococcus hirae (NCIMB 8192)) in 5 minutes at 20° C. under dirty conditions against all of the reference organisms detailed.", "Acticide PCMC (P-chloro-m-cresol) in the same concentration as in composition A, when diluted to 1:20 v/v, does not pass the requirements of EN 1276 for bactericidal activity (Pseudomonas aeruginosa (NCIMB 10421), Escherichia coli (NCTC 10418), Staphylococcus aureus (NCTC 10788), Enterococcus hirae (NCIMB 8192)) in 5 minutes at 20° C. under dirty conditions against all of the reference organisms detailed.", "Without wishing to be bound by theory, it is believed that the combination of Acticide BAC50M, Acticide DDQ 50, Acticide PHB 20, Acticide L and Acticide PCMC, according to compositions of the present invention, provides a synergistic effect in providing a disinfecting action.", "This synergistic effect is evidenced at least by the combination of these five components providing a bactericidal activity against Pseudomonas aeruginosa (NCIMB 10421), Escherichia coli (NCTC 10418), Staphylococcus aureus (NCTC 10788), Enterococcus hirae (NCIMB 8192) under an EN 1276 test; whilst under the same conditions each individual component does not pass the EN 1276 test.", "Additional comparative tests were carried out by D C Watson at Abbott Analytical, in New Ferry, UK, under a non-disclosure agreement.", "These tests were performed under the same European standard.", "Composition A passes the requirements of EN 13727:2012+A1:2013 for bactericidal activity (Pseudomonas aeruginosa (NCTC 13359)) in 5 minutes at 20° C. under dirty conditions.", "As an additional comparison, different solutions of mixtures of three (Table 2A) or four or five (Table 2B) of: Acticide BAC50M (Benzalkonium chloride: referred to as B in tables 2A and 2B), Acticide DDQ 50 (Didecyl Dimethyl Ammonium Chloride: referred to as A (i.e.", "individual component A rather than composition A above) in tables 2A and 2B), Acticide PHB 20 (Poly Hexamethylene Biguanide Hydrochloride: referred to as E is tables 2A and 2B), Acticide L (Bronopol: referred to as C in tables 2A and 2B) and Acticide PCMC (P-chloro-m-cresol: referred to as D in tables 2A and 2B); were all tested under the same conditions.", "In these tests, the same relative amounts of ethanol, ethylene glycol and water, as in composition A, were present.", "The results of Table 2A were obtained using a 1:20 v/v dilution of the ‘neat’ compositions.", "The results of Table 2B were obtained using a 1:60 v/v dilution of the ‘neat’ compositions.", "TABLE 2A effect of mixtures under EN 13727: 2012 + A1: 2013 against Pseudomonas aeruginosa (NCTC 13359) Lg reductions against Mix Pseudomonas aeruginosa ABC 4.04 BCD 3.96 CDE <3.86 DEA 4.47 ACE 4.50 BDA 3.97 TABLE 2B effect of mixtures under EN 13727: 2012 + A1: 2013 against Pseudomonas aeruginosa (NCTC 13359) Lg reductions against Mix Pseudomonas aeruginosa EABC 4.32 ABCD 3.98 CDEB <3.88 ACED 4.24 ABDE 4.61 ABCDE >5.24 Tables 2A and 2B show that the combination of Acticide BAC50M (Benzalkonium chloride: referred to as B in tables 2A and 2B), Acticide DDQ 50 (Didecyl Dimethyl Ammonium Chloride: referred to as A (i.e.", "individual component A rather than composition A above) in tables 2A and 2B), Acticide PHB 20 (Poly Hexamethylene Biguanide Hydrochloride: referred to as E is tables 2A and 2B), Acticide L (Bronopol: referred to as C in tables 2A and 2B) and Acticide PCMC (P-chloro-m-cresol: referred to as D in tables 2A and 2B) provides a greater log reduction against Pseudomonas aeruginosa (NCTC 13359) than any one component on its own and any possible combination of three or four of the components.", "As shown in Table 2B, higher dilutions also provide a disinfecting effect.", "Without wishing to be bound by theory, it is believed that the combination of Acticide BAC50M, Acticide DDQ 50, Acticide PHB 20, Acticide L and Acticide PCMC, according to compositions of the present invention, provides a synergistic effect in providing a disinfecting action.", "Sanitising Water Tests Dr Susanna Sherwin and Professor Bill Keevil, under a non-disclosure agreement, at the Environmental Healthcare Unit at the University of Southampton, UK, carried out tests on the efficiency of composition A as a water treatment.", "Their methods and results are set out below, with reference to the figures.", "1.Inactivation of Cryptosporidium parvum The tests aimed to determine the concentration of biocide SQ53 (neat composition A) needed to inactivate Cryptosporidium parvum oocysts.", "This was evaluated using Live/Dead staining, which detects whether the membrane of the oocyst has been damaged enough for the ‘dead’ stain to enter the cell.", "A range of dilutions of the neat SQ53 biocide were used.", "They are detailed in Table 3 below, along with the parts per million of active ingredients for each dilution.", "Concentrations known as 1:19 v/v and 1:15 v/v are named in this water treatment evaluation as dilutions 5% and 6.25%, respectively.", "TABLE 3 Concentrations of biocide SQ53 used in the study, along with their equivalent ppm levels.", "Dilutions of Actual parts concentrated SQ53 per million (ppm) used in studies (%) of dilutions 10.00 16,140.00 6.25 10,087.50 5.00 8,070.00 2.00 3,228.00 1.00 1,614.00 0.50 807.00 0.20 322.80 0.10 161.40 A. Incubation of C. parvum with Biocide and Subsequent Live/Dead Staining of Oocysts Cryptosporidium parvum oocysts were received in a 1 ml sample with a total of 1×107 oocysts.", "Each replicate used in this study consisted of a 10 μl aliquot of this stock, containing an average of 1×105 oocysts.", "Each concentration of biocide examined had three replicates per time-point examined.", "Each aliquot of oocysts were incubated for 24 hours in a final volume of 100 μl containing one of a range of concentrations of biocide SQ53 (Table 3).", "At 1 h prior to the time-point, the controls were subjected to 1 ml acidified HBSS (Hanks balanced salts solution (pH 2.75)) in order to allow the DAPI stain to penetrate the cell membrane.", "Incubations with the biocide occurred at 37° C., in the dark.", "At each time point, the samples were centrifuged at 13,000 rpm in a micro-centrifuge for 95 seconds, the supernatant (containing the biocide) was carefully removed, and the pellet was re-suspended (by vortexing) in neutral HBSS (pH 7) and washed by repeating this process three times.", "After the final centrifugation step, 100 μl HBSS supernatant was left with the pelleted oocysts, and 10 μl DAPI and 10 μl PI were added to the samples.", "The oocysts were re-suspended by vortexing, and were incubated with the Live/Dead stains for 2 h at 37° C. in the dark.", "After incubation with the live/dead stains, the oocysts were once again washed 2 times by centrifugation and re-suspension in neutral HBSS.", "After the final centrifugation step, 10-20 μl of supernatant was left with the sample, the oocysts were re-suspended by vortexing, and the total volume was placed in a glass spot slide and allowed to dry.", "Once the sample was dry, immersion oil was used to place a coverslip, and microscopy of the slides was carried out within 48 hours of sample preparation.", "B. Microscopy and Analysis of C. parvum Oocysts The C. parvum oocysts were analysed for the presence of the ‘dead’ stain PI and the counterstain DAPI.", "Each sample was examined under oil immersion epifluorescence microscopy, and photographs were taken of as many oocysts as possible, to allow for a count of >100 oocysts per replicate where possible.", "If oocysts numbers were low, photographs were taken of all oocysts visualised.", "Numbers of dead and live cells were then counted, and the percentage of live oocysts was calculated for each replicate sample.", "The average percentage survival was then calculated across the replicates.", "FIG.", "4 shows the percentage survival of C. parvum oocysts after 24 h incubation with a range of concentrations of biocide SQ53 (grey bars).", "The total oocysts counted to generate the percentage survival for each bar are shown by the dark grey line.", "Standard error bars are shown.", "C. 24 h Incubation with Biocide The levels of ‘live’ C. parvum recovered from the samples after incubation with biocide SQ53 for 24 h are shown in FIG.", "4.The lowest concentrations of biocide (0.01-0.02% SQ53) showed a maximum of only 16% reduction of viable oocysts after 24 hours, whereas the concentrations of biocide that were 0.5% of the concentrate and over showed a 80-90% reduction of viable oocysts, with the highest biocide concentration showing a 97% reduction of viable oocysts.", "The levels of oocyst recovery were high in this study and showed no correlation to the level of oocysts survival in the samples, which means that the results can be treated with high confidence.", "As mentioned above, contamination of swimming pool and recreational waters with the organism C. parvum is a serious problem around the world, for example in the UK.", "Once the waters become contaminated, it is easy for the organism to be transmitted into humans and infection can occur from as little as 132 oocysts (DuPont et al., (1995), The Infectivity of Cryptosporidium parvum in Healthy Volunteers, 332(13): 855-859).", "The current treatment of these waters with chlorine is ineffective to eliminate this organism, as previous studies have shown that treatment with 4 ppm chlorine at pH 7 for 25 hours resulted in no decrease in cell viability as seen by the DAPI/PI assay, and only a 40% reduction in cell viability when using the excystation assay (Widmer, (2002), Molecular mechanisms of chemical inactivation of Cryptosporidium oocysts and Giardia cysts, AWWA Research Foundation).", "In contrast to this, these tests show that the biocide SQ53 (neat composition A) can result in an 80-90% reduction in cell viability, when concentrations of 0.5% and higher are used.", "If concentrations of 10% are used, a reduction of 97% can be seen (FIG.", "4).", "This is a far more efficient treatment than 4 ppm chlorine.", "2.Inactivation of Klebsiella pneumoniae Dr Susanna Sherwin and Professor Bill Keevil, under a non-disclosure agreement, at the Environmental Healthcare Unit at the University of Southampton, UK, also tested the action of SQ53 (composition A) against the highly antibiotic resistant bacteria Klebsiella pneumoniae NDM-1 (New Delhi metallo-β-lactamase).", "The same concentrations as shown in Table 3, above, were used.", "Klebsiella pneumoniae was grown at 22° C. overnight in LB broth, with 150 rpm orbital shaking, to an optical density (OD620) of 0.6.Biocide SQ53 (composition A) was diluted in sterile water, and working stocks were calculated so that 20 μl of each working stock could be added to 180 μl culture to create final the concentrations shown in Table 3, above.", "Each control well received 20 μl sterile water in the place of biocide.", "Upon addition of culture, the plate was incubated at room temperature for 4 hours, and samples were taken for plating at 0 hours, 2 hours, and 4 hours.", "Samples were neutralised with neutralising broth, diluted in LB, and plated on LB agar plates.", "Plates were incubated at 37° C. overnight prior to counting viable cells (CFU).", "At 2 hours exposure to biocide, a 1/100 dilution of the treated culture was incubated in the dark with 50 μl live/dead stain for 30 minutes.", "100 μl of this sample was filtered onto a 0.2 μm pore size black polycarbonate filter and cell counts of total live and dead cells were recorded with episcopic differential interference contrast/epifluorescence (EDIC/EF) microscopy.", "Each filter was imaged at 10 random fields of view, and averages of these were used to calculate total cell counts per ml of filtered sample.", "Calculation of Numbers of Fields of View Per Filter One Field of View=11623.58 μm2 Filter membrane diameter=21000.00 μm Filter membrane area (π r2)=346360590.10 μm2 Numbers of Fields of View per filter=346360590.10/11623.58 29798.099 fields of view Therefore the overall average total cell count per field of view was multiplied by this factor to obtain total cell count per filter, and thus we could calculate total cell count per 1 ml of original culture.", "Treating the bacterium K. pneumoniae with SQ53 concentrations of 2% or higher resulted in an 8-log reduction of colony forming units (CFUs), with no culturable bacteria being detected at both 2 and 4 hours (FIG.", "5 and Table 4).", "When lower concentrations of biocide SQ53 were used however, the culturability of the bacteria were more variable, with between 4- to 5-log and 3- to 7-log reductions of bacteria (at 2 h and 4 h respectively), which were proportional to the concentration of biocide tested.", "FIG.", "5: Bacterial culturability of K. pneumoniae after treatment with various concentrations of biocide SQ53.K.", "pneumoniae was treated with SQ53 for 2 and 4 hours.", "Each study examined the effectiveness of biocide concentrations between 0.1-10%.", "Colony forming units (CFU·ml−1) were calculated after overnight growth at 37° C. TABLE 4 Log reductions in Klebsiella pneumoniae after incubation with 0.1-10% biocide SQ53.Biocide concentration 2H Agar 4H Agar (%) plate assay plate assay 10.00 3.08E+08 3.08E+08 6.25 3.08E+08 3.08E+08 5.00 3.08E+08 3.08E+08 2.00 3.08E+08 3.08E+08 1.00 3.08E+08 2.80E+07 0.50 3.51E+05 3.08E+08 0.20 1.29E+05 6.14E+04 0.10 3.84E+04 3.08E+03 0.00 1.00E+00 1.00E+00 For the bacterium K. pneumoniae, standard culturability tests demonstrated that incubation with the biocide SQ53 resulted in a 4- to 5-log reduction of the bacteria at biocide concentrations of 1% or lower at 2 hours, and a 3- to 7-log reduction of the bacteria at biocide concentrations of 1% or lower at 4 hours.", "At biocide concentrations of 2% and over, an 8-log reduction of bacteria was seen, with no culturable cells being detected (FIG.", "5 and Table 4).", "This means that at concentrations of 2% and higher, the biocide SQ53 inactivates 8-log of K. pneumoniae organisms.", "3.Desirable Characteristics of a Water Treatment Table 5 discusses, qualitatively, desirable properties of water treatment biocides.", "Table 5 is a modified extract from the book “Directory of Microbicides for the Protection of Materials”, edited by Wilfried Paulus, Kluwer Academic Publishers, 2004, Section 5.3, Unhoch et al., “Recreational Water Treatment Biocides”.", "This extract states that the “required characteristics” in the left hand column of Table 5 are desired characteristics of water treatment biocides, for example for use in sanitising recreational water systems.", "Table 5 shows that composition A (referred to as SQ53 in Table 5) satisfies the desired characteristics of a water sanitising biocide.", "Use of composition A in water sanitising provides a combination of characteristics which is not seen in other water sanitising techniques.", "Required Copper Colloidal Polyhexamethylene SQ Characteristic Salts Silver Chlorine Bromine biguanide Ozone UV 53 Effective against Partial Partial Yes Yes Partial Yes Yes Yes both pathogens and nuisance microorganisms Low order of Partial Partial Yes Partial Yes If Yes Yes toxicity or controlled preferably non toxic to humans, animals and plant life Safe to handle Yes Yes No No Yes Yes Yes Yes Does not degrade Yes Yes No No Yes Yes Yes Yes into or react with other pool or spa chemicals to form harmful disinfection by products Suitable shelf life Yes Yes No No Yes N/A N/A Yes at storage temperatures for a minimum of 1 year Efficacious in No No No No Yes Yes No Yes presence of and stable to organic impurities from bathers and environment, high and low water temperature, pH variations, differing water qualities and sunlight Should not impart Yes Yes No No Yes No Yes Yes colour, odour or taste to the water Able to be Yes Yes Yes Yes No Yes No Yes monitored with a simple point of use test kit Should not No No No No Yes No Yes Yes discolour/damage pool and spa surfaces and equipment Flocculation No No No No No No No Yes performance Biofilm No No Partial Partial Partial Partial No Yes Stability Composition A has been found to be stable, i.e.", "not to lose any of its activity in cleaning surfaces, up to 12 months after initial preparation of the composition.", "As can be seen from the above results, it is clear that a product in accordance with the present invention is able to act as a cleaning liquid which has beneficial properties.", "When used in this specification and claims, the terms “comprises” and “comprising” and variations thereof mean that the specified features, steps or integers are included.", "The terms are not to be interpreted to exclude the presence of other features, steps or components.", "The features disclosed in the foregoing description, or the following claims, or the accompanying drawings, expressed in their specific forms or in terms of a means for performing the disclosed function, or a method or process for attaining the disclosed result, as appropriate, may, separately, or in any combination of such features, be utilised for realising the invention in diverse forms thereof." ] ]
Patent_15874399
[ [ "SEMICONDUCTOR DEVICE PACKAGES WITH DIRECT ELECTRICAL CONNECTIONS AND RELATED METHODS", "Semiconductor device packages in accordance with this disclosure may include a substrate and a stack of semiconductor dice attached to the substrate.", "An uppermost semiconductor die of the stack of semiconductor dice located on a side of the stack of semiconductor dice opposite the substrate may be a heat-generating component configured to generate more heat than each other semiconductor die of the stack of semiconductor dice.", "Electrical connectors may extend directly from the uppermost semiconductor die to the substrate." ], [ "1.A semiconductor device package, comprising: a substrate; a stack of semiconductor dice attached to the substrate, an uppermost semiconductor die of the stack of semiconductor dice located on a side of the stack of semiconductor dice opposite the substrate being a heat-generating component configured to generate more heat than underlying semiconductor dice of the stack located between the uppermost semiconductor die and the substrate, an active surface of the uppermost semiconductor die facing the underlying semiconductor dice; vias extending through underlying semiconductor dice, the vias electrically interconnecting the underlying semiconductor dice to one another and to the substrate; electrical conductors located between the uppermost semiconductor die and the underlying semiconductor dice; electrical connectors extending directly from the uppermost semiconductor die to the substrate; and an encapsulation material at least partially surrounding the stack of semiconductor dice, an inactive surface of the uppermost semiconductor die remaining exposed.", "2.The semiconductor device package of claim 1, wherein the encapsulation material is flush with the inactive surface of the uppermost semiconductor die.", "3.The semiconductor device package of claim 1, further comprising: a heat sink located on a side of the uppermost semiconductor die opposite the substrate; and a passivation material located between the uppermost semiconductor die and the heat sink.", "4.The semiconductor device package of claim 3, further comprising a thermal interface material located between the passivation material and the heat sink.", "5.The semiconductor device package of claim 4, wherein the thermal interface material is electrically conductive.", "6.The semiconductor device package of claim 1, wherein the electrical connectors are located laterally adjacent to the vias.", "7.The semiconductor device package of claim 6, wherein the electrical connectors extend longitudinally through portions of the semiconductor dice in the stack of semiconductor dice between the substrate and the uppermost semiconductor die.", "8.The semiconductor device package of claim 7, wherein a size and shape of the uppermost semiconductor die is at least substantially equal to a size and shape of each other semiconductor die in the stack of semiconductor dice.", "9.The semiconductor device package of claim 1, wherein the substrate and the uppermost semiconductor die are larger in at least one lateral dimension than the underlying semiconductor dice, and the electrical connectors extend through at least one interposer located laterally adjacent to the underlying semiconductor dice between at least one portion of each of the substrate and the uppermost semiconductor die.", "10.The semiconductor device package of claim 9, wherein the substrate and the uppermost semiconductor die are larger in each lateral dimension than each corresponding lateral dimension of the underlying semiconductor dice and wherein the at least one interposer peripherally surrounds the underlying semiconductor dice between the substrate and the uppermost semiconductor die.", "11.The semiconductor device package of claim 9, wherein the at least one interposer is located peripherally adjacent to the underlying semiconductor dice and further comprising at least another interposer located peripherally adjacent to the underlying semiconductor dice on a side of the stack opposite the at least one interposer, the at least another interposer comprising additional electrical connectors forming another direct electrical connection between the substrate and the uppermost semiconductor die.", "12.The semiconductor device package of claim 1, wherein each underlying semiconductor die in the stack of semiconductor dice between the substrate and the uppermost semiconductor die comprises a memory die and the uppermost semiconductor die comprises a logic die.", "13.The semiconductor device package of claim 1, wherein a thickness of the uppermost semiconductor die as measured in a direction perpendicular to the active surface of the uppermost semiconductor die is about 200 μm or greater.", "14.The semiconductor device package of claim 1, wherein the uppermost semiconductor die is free of vias.", "15.A method of making a semiconductor device package, comprising: forming a stack of semiconductor dice on a substrate, an uppermost semiconductor die of the stack of semiconductor dice located on a side of the stack of semiconductor dice opposite the substrate and being a heat-generating component configured to generate more heat than each underlying semiconductor die of the stack located between the uppermost semiconductor die and the substrate, an active surface of the uppermost semiconductor die facing the underlying semiconductor dice; forming a direct electrical connection between the substrate and the uppermost semiconductor die in electrical isolation from integrated circuitry of the other semiconductor dice of the stack of semiconductor dice; and at least partially surrounding the stack of semiconductor dice in an encapsulation material, leaving an inactive surface of the uppermost semiconductor die exposed.", "16.The method of claim 15, further comprising: placing a passivation material on a side of the uppermost semiconductor die opposite the substrate; and placing a heat sink over the passivation material.", "17.The method of claim 16, further comprising placing a thermal interface material over the passivation material before placing the heat sink.", "18.The method of claim 17, wherein placing the thermal interface material over the passivation material comprises placing an electrically conductive thermal interface material over the passivation material.", "19.The method of claim 15, further comprising refraining from thinning the uppermost semiconductor die from a wafer-level thickness as measured in a direction perpendicular to an active surface of the uppermost semiconductor die.", "20.The method of claim 15, wherein forming the stack of semiconductor dice on the substrate comprises forming a stack of semiconductor dice comprising vias extending through each semiconductor die other than the uppermost semiconductor die to the substrate, the vias electrically interconnected to one another and to the uppermost semiconductor die and the substrate." ], [ "<SOH> BACKGROUND <EOH>When in use, some semiconductor devices generate significant quantities of heat.", "Thermal management techniques may be employed to conduct heat away from such semiconductor devices and other components near such semiconductor devices.", "For example, U.S. Patent Application Pub.", "No.", "2014/0015598, published Jan. 14, 2014 and titled “SEMICONDUCTOR DEVICE PACKAGES INCLUDING THERMALLY INSULATING MATERIALS AND METHODS OF MAKING AND USING SUCH SEMICONDUCTOR PACKAGES” discloses that a thermally insulating material may be positioned on peripheries of dice in a die stack to alter the path of least resistance for heat transfer from a heat-generating region of a base die extending laterally beyond the thermally insulating material on a lowest die in the stack.", "When thermal management techniques used to conduct heat away from heat generating semiconductor devices are inadequate, the resulting temperatures may degrade performance of such semiconductor devices, may degrade performance of other components near such semiconductor devices, may damage such semiconductor devices, may damage other components near such semiconductor devices, and may even injure a user near that semiconductor device." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>While this disclosure concludes with claims particularly pointing out and distinctly claiming specific embodiments, various features and advantages of embodiments within the scope of this disclosure may be more readily ascertained from the following description when read in conjunction with the accompanying drawings, in which: FIG.", "1 is a cross-sectional view of a semiconductor device package; FIG.", "2 is a perspective view of one embodiment of a portion of the semiconductor device package of FIG.", "1 ; FIG.", "3 is a perspective view of another embodiment of the portion of the semiconductor device package of FIG.", "1 ; FIG.", "4 is a cross-sectional view of another embodiment of a semiconductor device package; FIG.", "5 is a cross-sectional view of still another embodiment of a semiconductor device package; and FIG.", "6 is a cross-sectional view of yet another embodiment of a semiconductor device package.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/401,762, filed Jan. 9, 2017, which is a continuation of U.S. patent application Ser.", "No.", "14/605,466, filed Jan. 26, 2015, now U.S. Pat.", "No.", "9,543,274, issued Jan. 10, 2017, the disclosure of each of which is incorporated herein in its entirety by this reference.", "FIELD This disclosure relates generally to semiconductor device packages and methods of packaging semiconductor devices.", "More specifically, disclosed embodiments relate to semiconductor device packages and methods of packaging semiconductor devices that may improve thermal management of the semiconductor device packages.", "BACKGROUND When in use, some semiconductor devices generate significant quantities of heat.", "Thermal management techniques may be employed to conduct heat away from such semiconductor devices and other components near such semiconductor devices.", "For example, U.S. Patent Application Pub.", "No.", "2014/0015598, published Jan. 14, 2014 and titled “SEMICONDUCTOR DEVICE PACKAGES INCLUDING THERMALLY INSULATING MATERIALS AND METHODS OF MAKING AND USING SUCH SEMICONDUCTOR PACKAGES” discloses that a thermally insulating material may be positioned on peripheries of dice in a die stack to alter the path of least resistance for heat transfer from a heat-generating region of a base die extending laterally beyond the thermally insulating material on a lowest die in the stack.", "When thermal management techniques used to conduct heat away from heat generating semiconductor devices are inadequate, the resulting temperatures may degrade performance of such semiconductor devices, may degrade performance of other components near such semiconductor devices, may damage such semiconductor devices, may damage other components near such semiconductor devices, and may even injure a user near that semiconductor device.", "BRIEF DESCRIPTION OF THE DRAWINGS While this disclosure concludes with claims particularly pointing out and distinctly claiming specific embodiments, various features and advantages of embodiments within the scope of this disclosure may be more readily ascertained from the following description when read in conjunction with the accompanying drawings, in which: FIG.", "1 is a cross-sectional view of a semiconductor device package; FIG.", "2 is a perspective view of one embodiment of a portion of the semiconductor device package of FIG.", "1; FIG.", "3 is a perspective view of another embodiment of the portion of the semiconductor device package of FIG.", "1; FIG.", "4 is a cross-sectional view of another embodiment of a semiconductor device package; FIG.", "5 is a cross-sectional view of still another embodiment of a semiconductor device package; and FIG.", "6 is a cross-sectional view of yet another embodiment of a semiconductor device package.", "DETAILED DESCRIPTION The illustrations presented in this disclosure are not meant to be actual views of any particular semiconductor device package or component thereof, but are merely idealized representations employed to describe illustrative embodiments.", "Thus, the drawings are not necessarily to scale.", "Disclosed embodiments relate generally to semiconductor device packages and methods of packaging semiconductor devices that may improve thermal management of the semiconductor device packages.", "More specifically, disclosed are embodiments of semiconductor device packages wherein a semiconductor die configured to generate the most heat in a stack of semiconductor dice may be located at a top of the stack and the topmost semiconductor die may be directly electrically connected to the package substrate.", "Referring to FIG.", "1, a cross-sectional view of a semiconductor device package 100 is shown.", "The semiconductor device package 100 may include a substrate 102.The substrate 102 may include electrically conductive elements 104, such as, for example, bumps, balls, studs, or posts of electrically conductive material (e.g., solder), configured to electrically connect the semiconductor device package 100 to another structure.", "The conductive elements 104 may be located, for example, on a bottom surface of the semiconductor device package 100, protruding from a surface of substrate 102.The substrate 102 may include conductive pads 106 on a surface of the substrate 102 opposing the conductive elements 104.The conductive pads 106 may be of an electrically conductive material (e.g., copper) and may be positioned and configured to form electrical connections with an overlying structure.", "The substrate 102 may include circuitry to electrically connect the conductive pads 106 to the conductive elements 104, which circuitry may extend through a thickness of the substrate 102.The substrate 102 may be, for example, a printed circuit board, a ceramic, or a substrate of semiconductor material.", "The semiconductor device package 100 may further include a stack of semiconductor dice 108 attached and electrically connected to the substrate 102.In some embodiments, the semiconductor dice 108 may be memory dice, such as, for example, dynamic random access memory (DRAM) dice.", "A total number of additional semiconductor dice 108 in the stack may be, for example, three, five, seven, eleven, fifteen, or more.", "Each semiconductor die 108 may comprise conductive vias 110 extending through a thickness of the semiconductor die 108 to establish electrical connections between the semiconductor dice 108 and the conductive pads 106 of the substrate 102.More specifically, each semiconductor die 108 may include a plurality of conductive vias 110 (e.g., a matrix of vias 110) extending through a thickness thereof to provide electrical connections between an active surface 112 of each semiconductor die 108 and an opposing inactive surface 114 (e.g., a back side surface) thereof.", "The active surfaces 112 of the semiconductor dice 108 may be located on a side of each respective semiconductor die 108 opposing the substrate 102, and the conductive vias 110 may electrically connect semiconductor dice 108 to one another and to the substrate 102 through aligned conductive pillars 126.Each conductive via 110 may include, for example, a hole extending through the respective semiconductor die 108, an electrically conductive material located within the hole, and a passivation material lining a sidewall defining the hole to electrically isolate the conductive material from the surrounding semiconductor material of the semiconductor die 108.A dielectric underfill material 116 (e.g., capillary underfill, nonconductive paste, or wafer-level underfill) may be located between the semiconductor dice 108 and between the lowermost semiconductor die 108 of the stack and the substrate 102 in some embodiments.", "More specifically, underfill material 116 may be located between, and in contact with, the semiconductor dice 108 of the stack and between the lowermost semiconductor die 108 and the substrate 102, the underfill surrounding the conductive pillars 126.Suitable underfill materials 116 are commercially available, for example, from Sumitomo Plastics America, Inc. of Santa Clara, Calif.", "The semiconductor device package 100 may include another semiconductor die 118 electrically connected to the stack of semiconductor dice 108 and located on a side of the stack of semiconductor dice 108 opposing the substrate 102.The other semiconductor die 118 may be configured to generate more heat when in use than each semiconductor die 108 located in the stack between the other semiconductor die 118 and the substrate 102.For example, the other semiconductor die 118 may be configured to generate more heat when in use than any other component of the semiconductor device package 100.More specifically, the other semiconductor die 118 may include, for example, logic circuitry (e.g., may be a logic die), which may cause the other semiconductor die 118 to generate the most heat of any component of the semiconductor device package 100.As a specific, nonlimiting example, the other semiconductor die 118 may be a logic die including a high-power serializer/deserializer (e.g., a SERDES) and, in some embodiments, other high-power integrated circuitry (for example, a system-on-a-chip), which may cause the other semiconductor die 118 to generate the most heat of any active component of the semiconductor device package 100.The other semiconductor die 118 may be a heat-generating component located farthest from the substrate 102 when compared to each other heat-generating component in the semiconductor device package 100.For example, the other semiconductor die 118 may be a heat-generating component located nearest any heat dissipation structures utilized in connection with the semiconductor device package 100.More specifically, the other semiconductor die 118 may be, for example, the topmost die in a stack of semiconductor dice including the aforementioned semiconductor dice 108 in the stack and the other semiconductor die 118.When fabricating semiconductor device packages, such as those shown in FIGS.", "4A and 4B in U.S. Patent Application Pub.", "No.", "2014/0015598 in which the heat-generating component configured to generate the most heat during operation is not located distant from the substrate (e.g., where the logic die is located adjacent to the substrate and a stack of memory dice is located on the opposite side of the logic die), the real-world steady-state operational temperatures reached by dice within such packages may not match those predicted using simulation techniques (e.g., finite element analysis).", "Unexpectedly high temperatures may exceed the recommended operating temperatures of the components of the packages, which may degrade performance, damage the components, or even cause the packages to fail.", "More specifically, the logic die may be heated to temperatures exceeding 105° C. and one or more of the memory dice may be heated to temperatures exceeding 95° C. by about 20° C. or more, with a temperature differential between the logic die and the top of the stack of memory dice being on the order of 40° C. By positioning the other semiconductor die 118 farther from the substrate 102 than other heat-generating components in the semiconductor device package 100, heat generated by the other semiconductor die 118 may be more easily dissipated and otherwise managed.", "For example, a resulting operational temperature of at least some components of the semiconductor device package 100 may be 10° C. or more cooler than a resulting operational temperature of similar components in embodiments where the other semiconductor die 118 is located closer to the substrate 102 (e.g., adjacent to the substrate 102, at a bottom of a semiconductor die stack), which may cause the actual operational temperatures reached by the semiconductor dice 108 in the stack and the other semiconductor die 118 to remain at or below recommended maximum operating temperatures for the semiconductor dice 108 in the stack and the other semiconductor die 118.More specifically, the resulting operational temperature of at least some components of the semiconductor device package 100 may be, for example, at least 20° C. cooler than a resulting temperature of similar components in embodiments where the other semiconductor die 118 is located closer to the substrate 102, and temperature differential between the other semiconductor die 118 and the exterior of an overlying heat spreader 132 (FIG.", "1) may be only about 20° C. Such reductions in temperatures may maintain the actual operational temperatures of the semiconductor (memory) dice 108 in the stack at or below 95° C., and may maintain the actual temperature of the other (logic) semiconductor die 118 at or below 105° C., which temperature reduction may maintain quality of performance, reduce the likelihood of temperature damage being inflicted on the components, and reduce the failure rate of the packages 100.In some embodiments, the other semiconductor die 118 may be free of vias 110.For example, an active surface 120 of the other semiconductor die 118 may be located on the side of the other semiconductor die 118 facing an adjacent semiconductor die 108 in the stack, enabling electrical connection of integrated circuitry of the active surface 120 to the adjacent semiconductor die 108 in the stack without requiring the electrical connections to extend through the other semiconductor die 118.More specifically, the active surface 120 of the other semiconductor die 118 may face the substrate 102, an inactive surface 122 of the other semiconductor die 118 may be located on a side of the other semiconductor die 118 opposing the substrate 102, and electrical conductors 124 (e.g., conductive bumps, pillars, balls, studs, etc.)", "may electrically connect the other semiconductor die 118 to the adjacent semiconductor die 108 in the stack without passing through the other semiconductor die 118.When the other semiconductor die 118 lacks vias, a wider variety of architectures for the integrated circuitry of the other semiconductor die 118 may be available.", "For example, the integrated circuitry of the active surface 120 of the other semiconductor die 118 may not be limited to a 32-micron architecture because it need not be connected to any vias 110.In some embodiments, a thickness T of the other semiconductor die 118 may not be thinned subsequent to formation of the integrated circuitry on the active surface of the other semiconductor die.", "For example, the thickness T of the other semiconductor die 118 in a direction perpendicular to the active surface 120 of the other semiconductor die 118 may approach, or even be equal to the thickness T of a wafer from which the other semiconductor die 118 was singulated.", "More specifically, the thickness T of the other semiconductor die 118 may be about 200 microns or greater.", "As a specific, nonlimiting example, the thickness T of the other semiconductor die 118 may be about 300 microns, about 400 microns, or greater.", "Leaving the other semiconductor die 118 at full thickness T may render the other semiconductor die 118, and the semiconductor device package 100 of which it is a part, mechanically stronger and stiffer.", "In other embodiments, however, for example, when height of the semiconductor package 100 may be an issue, the thickness T of the other semiconductor die 118 may be thinned relative to the wafer from which the other semiconductor die 118 was singulated.", "More specifically, the thickness T of the other semiconductor die 118 may be, for example, about 100 microns or less.", "As a specific, nonlimiting example, the thickness T of the other semiconductor die 118 may be about 50 microns or less (e.g., about 25 microns).", "In some embodiments, the semiconductor device package 100 may lack any encapsulation material located on the side of the other semiconductor die 118 opposing the first semiconductor die 108.For example, the inactive surface 122 of the other semiconductor die 118 may be free of (e.g., may not be in contact with) encapsulation material.", "More specifically, the other semiconductor die 118 may be, for example, unencapsulated, such that encapsulation material does not contact any surface of the other semiconductor die 118.In some embodiments, the semiconductor device package 100 may be free of underfill material 116 between the other semiconductor die 118 and the adjacent semiconductor die 108 in the stack.", "In other embodiments, underfill material 116 may be located between the other semiconductor die 118 and the adjacent semiconductor die 108 and surrounding the electrical conductors 124.The semiconductor device package 100 may include one or more electrical connectors 128 located peripherally adjacent to the vias 110 of semiconductor dice 108 and directly electrically connecting the other semiconductor die 118 to the substrate 102.For example, the semiconductor device package 100 may include high-speed electrical connectors 128 located laterally adjacent to the stack of semiconductor dice 108 between the other semiconductor die 118 and the substrate 102 in the stack and extending from the active surface 120 of the other semiconductor die 118 to the conductive pads 106 of the substrate 102.More specifically, the semiconductor device package 100 may include high-speed electrical connectors 128 which may not include direct electrical connections to the integrated circuitry of the semiconductor dice 108 of the stack between the other semiconductor die 118 and the substrate 102 extending from the active surface 120 of the other semiconductor die 118 to the conductive pads 106 of the substrate 102 to directly electrically connect the other semiconductor die 118 to the substrate 102.The electrical connectors 128 may include, for example, an electrically conductive material (e.g., copper, aluminum, gold, or silver) extending through a material exhibiting high thermal conductivity (e.g., a thermal conductivity of about 1.5 W/m·K, 15 W/m·K, 100 W/m·K, 150 W/m·K or more) or low thermal conductivity (e.g., a thermal conductivity of about 1 W/m·K or less).", "In some embodiments, the electrical connectors 128 may extend through one or more interposers 130 located between the other semiconductor die 118 and the substrate 102.For example, the electrical connectors 128 may constitute conductive vias extending through one or more interposers 130 located laterally adjacent to the stack of semiconductor dice 108 between the other semiconductor die 118 and the substrate 102, which conductive vias may each include a high-aspect ratio aperture extending through the interposer 120, an electrically conductive material (e.g., copper) located within the aperture, and a passivation material lining a sidewall defining the hole to electrically isolate the conductive material from the surrounding material of the interposer 130.A height H1 of the interposer 130 above the substrate 102 may be at least substantially equal to a combined height H2 of the stack of semiconductor dice 108 between the other semiconductor die 118 and the substrate 102.The interposer 130 may be, for example, a printed circuit board (PCB), a liquid crystal polymer (LCP), or a mass of silicon (e.g., a silicon window) through which the electrical connectors 128 extend.", "If the interposer 130 is formed of an electrically conductive material, the electrical connectors 128 may be electrically isolated from the electrically conductive material by a surrounding passivation layer in each aperture.", "In embodiments where the electrical connectors 128 extend through one or more interposers 130, a surface area of the active surface 120 of the other semiconductor die 118 may be greater than a surface area of the active surfaces of the stack of semiconductor dice 108 located between the semiconductor die 118 and the substrate 102.In other words, at least one dimension of the other semiconductor die 118 may be greater than a corresponding dimension of the semiconductor dice 108 in the stack, such that the other semiconductor die 118 overhangs the stack.", "More specifically, the substrate 102 and the other semiconductor die 118 may be, for example, larger in at least one lateral dimension than the semiconductor dice 108 in the stack between the semiconductor die 118 and the substrate 102, and the electrical connectors 128 may extend through at least one interposer 130 located adjacent to the stack of semiconductor dice 108 between at least one portion of each of the substrate 102 and the other semiconductor die 118 extending laterally beyond at least one side of the stack of semiconductor dice 108.As a specific, nonlimiting example, the substrate 102 and the other semiconductor die 118 may be larger in length and width than a length and width of semiconductor dice 108 in the stack between the semiconductor die 118 and the substrate 102, and the interposer 130 may peripherally surround the stack of semiconductor dice 108 between the substrate 102 and the other semiconductor die 118 between a portion of each of the substrate 102 and the other semiconductor die 118 extending laterally beyond sides of the stack of semiconductor dice 108.FIG.", "2 is a perspective view of one embodiment of a portion 100A of the semiconductor device package 100 of FIG.", "1.In some embodiments, the semiconductor device package 100 (see FIG.", "1) may include two or more interposers 130A and 130B located laterally adjacent to the stack of semiconductor dice 108 between the other semiconductor die 118 (see FIG.", "1) and the substrate 102.For example, two interposers 130A and 130B may laterally flank the semiconductor dice 108 in the stack between the other semiconductor die 118 (see FIG.", "1) and the substrate 102.More specifically, the interposers 130A and 130B may extend along a length of the stack of semiconductor dice 108 between the other semiconductor die 118 (see FIG.", "1) and the substrate 102 on two opposing sides of the semiconductor dice 108.As a specific, nonlimiting example, two interposers 130A and 130B in the form of strips may be of at least substantially equal length as the stack of semiconductor dice 108 between the other semiconductor die 118 (see FIG.", "1) and the substrate 102 may be located on the two opposing sides of the semiconductor dice 108.In other embodiments, two or more interposers may be located laterally adjacent to the semiconductor dice 108 in the stack between the other semiconductor die 118 (see FIG.", "1) and the substrate 102 on a single side of the semiconductor dice 108 or on two adjacent sides of the semiconductor dice 108.FIG.", "3 is a perspective view of another embodiment of a portion 100B of the semiconductor device package 100 of FIG.", "1.In other embodiments, the semiconductor device package 100 (see FIG.", "1) may include one interposer 130′ located laterally adjacent to the stack of semiconductor dice 108 between the other semiconductor die 118 (see FIG.", "1) and the substrate 102.For example, a single interposer 130′ may laterally surround the stack of semiconductor dice 108 between the other semiconductor die 118 (see FIG.", "1) and the substrate 102.More specifically, the interposer 130′ may be configured as a frame and extend entirely around the stack of semiconductor dice 108 between the other semiconductor die 118 (see FIG.", "1) and the substrate 102 on four sides of the semiconductor dice 108.In other examples, one interposer 130′ may extend along one side, two adjoining sides, or three sides of the stack of semiconductor dice 108 between the other semiconductor die 118 (see FIG.", "1) and the substrate 102.Returning to FIG.", "1, the semiconductor device package 100 may include a heat spreader 132 in some embodiments.", "For example, the heat spreader 132 may be located on a side of the other semiconductor die 118 opposing the substrate 102, and may be in thermal communication with the other semiconductor die 118.More specifically, the heat spreader 132 may extend over the inactive surface 122 of the other semiconductor die 118, down past the peripheries of the stack of semiconductor dice 108 between the other semiconductor die 118 and the substrate 102, and the interposer 130, and be attached to the substrate 102 (e.g., using an adhesive material 134).", "The heat spreader 132 may be of a thermally conductive material, such as, for example, copper, silicon carbide, aluminum, gold, or a thermally conductive alloy.", "In some embodiments, a thermal interface material 136 (TIM) may be located between the other semiconductor die 118 and the heat spreader 132.The TIM 136 may be a thermally conductive material configured to facilitate heat transfer from the other semiconductor die 118 to the heat spreader 132.In some embodiments, the TIM 136 may be an electrically conductive material, which may enable the TIM 136 to exhibit a higher thermal conductivity than an electrically insulating TIM.", "Utilizing a topmost, other semiconductor die 118 free of vias may enable use of an electrically conductive TIM 136 because there may not be any electrical connectors (e.g., vias) on the inactive surface 122 of the other semiconductor die 118 that may be undesirably electrically interconnected by the electrically conductive TIM 136.In other embodiments, the TIM 136 may be an electrically insulating material.", "A thermal conductivity of the TIM 136 may be, for example, greater than about 1.2 W/m·K.", "More specifically, the thermal conductivity of the TIM 136 may be, for example, between about 2 W/m·K and about 200 W/m·K (e.g., about 3.2 W/m·K).", "The TIM 136 may be, for example, a thermal gel (e.g., a silicone-based curable gel), a thermal adhesive, a thermal grease, a phase change material (e.g., a phase change metal alloy), a solder, or a carbon nanotube material.", "In still other embodiments, the semiconductor device package 100 may lack any TIM, and the heat spreader 132 may directly contact the inactive surface 122 of the other semiconductor die 118.In some embodiments, a passivation material 138 may be located between the heat spreader 132 and the other semiconductor die 118.For example, a passivation material 138 may be located between the other semiconductor die 118 and the TIM 136, which may be located between the passivation material 138 and the heat spreader 132.The passivation material 138 may be an electrically insulating material, and may reduce the likelihood that metal material from the heat spreader 132, the TIM 136, or both will diffuse into and contaminate semiconductor material of the other semiconductor die 118.In other words, semiconductor device packages in accordance with this disclosure may include a substrate and a stack of semiconductor dice attached to the substrate.", "The stack of semiconductor dice may include vias extending through each semiconductor die of the stack for electrically interconnecting the semiconductor dice in the stack to one another and to the substrate.", "Another semiconductor die may be electrically connected to the stack of semiconductor dice and may be located on a side of the stack of semiconductor dice opposing the substrate.", "The other semiconductor die may be a heat-generating component configured to generate more heat than each semiconductor die of the stack of semiconductor dice.", "Electrical connectors may be located laterally adjacent to the vias and may form electrical connections between the substrate and the other semiconductor die in isolation from integrated circuitry of the semiconductor dice in the stack.", "The semiconductor device package 100 may be assembled generally from the substrate 102 upward in some embodiments.", "For example, the stack of semiconductor dice 108 may be positioned on and electrically connected to the conductive pads 106 of the substrate 102 utilizing the vias 110 and the conductive pillars 126.The underfill material 116 may be positioned between each adjacent pair of semiconductor dice 108 and the substrate 102 one layer at a time, or in one step after the stack of semiconductor dice 108 is in place.", "Each interposer 130 may be positioned laterally adjacent to the stack of semiconductor dice 108 on the substrate 102, and may be electrically connected to the conductive pads 106 of the substrate 102 utilizing the electrical connectors 128.The other semiconductor die 118 may be positioned over, and electrically connected to, the electrical connectors 128 of each interposer 130 and the stack of semiconductor dice 108 with the active surface 120 of the other semiconductor die 118 facing the substrate 102.A passivation material 138 may be positioned on the inactive surface 122 of the other semiconductor die 118.A TIM 136 may be positioned on the passivation material 138 on a side opposing the other semiconductor die 118.Finally, a heat spreader 132 may be positioned on the TIM 136 and may be secured to the substrate 102 at a periphery of the substrate 102 using an adhesive material 134.In other embodiments, the semiconductor device package 100 may be generally assembled from the other semiconductor die 118 downward (referring to the orientation as depicted in FIG.", "1.For example, the other semiconductor die 118 may be positioned with its active surface 120 facing upward (e.g., may be flipped), and the topmost next semiconductor die 108 in the stack may be positioned on, and electrically connected to, the active surface 120 of the other semiconductor die 118 utilizing the electrical conductors 124 and the vias 110.The rest of the semiconductor dice 108 may be stacked on, and electrically connected to, the next semiconductor die 108 to form a stack on the other semiconductor die 118.Such assembly may be effected with an array of unsingulated other semiconductor dice 118 at the wafer level, and the resulting assembly singulated thereafter.", "Each interposer 130 may be positioned laterally adjacent to the semiconductor dice 108 on the other semiconductor die 118, and the electrical connectors 128 of each interposer 130 may be electrically connected to the other semiconductor die 118 utilizing the electrical conductors 124.The other semiconductor die 118, the stack of semiconductor dice 108, and each interposer 130 may be inverted such that the active surface 120 of the other semiconductor die 118 faces the substrate 102 and may be positioned over, and electrically connected to, the conductive pads 106 of the substrate 102.The underfill material 116 may be positioned between the other semiconductor die 118 and the adjacent semiconductor die 108 as well as between each adjacent pair of semiconductor dice 108 one layer at a time, or in one step after disposition on the other semiconductor die 118.A passivation material 138 may be positioned on the inactive surface 122 of the other semiconductor die 118 at the wafer level, if desirable.", "A TIM 136 may be positioned on the passivation material 138 on a side opposing the other semiconductor die 118.Finally, a heat sink in the form of, for example, heat spreader 132 may be positioned on the TIM 136 and may be secured to the substrate 102 at a periphery of the substrate 102 using an adhesive material 134.In other words, methods of making semiconductor device packages in accordance with this disclosure may involve attaching a stack of semiconductor dice to a substrate, the stack of semiconductor dice comprising vias extending through each semiconductor die of the stack for electrically interconnecting the semiconductor dice in the stack to one another and to the substrate.", "Another semiconductor die may be positioned on a side of the stack of semiconductor dice opposing the substrate and may be electrically connected to the first semiconductor die.", "The other semiconductor die may be a heat-generating component configured to generate more heat than each semiconductor die of the stack of semiconductor dice.", "A direct electrical connection may be formed between the substrate and the other semiconductor die in electrical isolation from integrated circuitry of the semiconductor dice of the stack utilizing electrical connectors located laterally adjacent to the vias.", "FIG.", "4 is a cross-sectional view of another embodiment of a semiconductor device package 140.The semiconductor device package 140 of FIG.", "4 may be generally similar to the semiconductor device package 100 of FIG.", "1, with specific differences described as follows.", "In some embodiments, the semiconductor device package 140 may lack any separate interposer 130 (see FIG.", "1) for directly electrically connecting the other semiconductor die 118 to the substrate 102.For example, the electrical connectors 128 may extend through portions of the semiconductor dice 108 in the stack between the other semiconductor die 118 and the substrate 102.More specifically, the electrical connectors 128 may extend, for example, through portions of the semiconductor dice 108 in the stack between the other semiconductor die 118 and the substrate 102 located laterally adjacent to the vias 110 and unconnected to integrated circuitry of the semiconductor dice 108.As a specific, nonlimiting example, the electrical connectors 128 may extend through the semiconductor dice 108 in the stack between the other semiconductor die 118 and the substrate 102 at the peripheries thereof in portions lacking integrated circuitry.", "In such embodiments, a surface area of the active surface 120 of the other semiconductor die 118 may be at least substantially equal to a surface area of the active surface 112 of each other semiconductor die 108 in the stack.", "Stated another way, the semiconductor dice 108 of the stack may be of substantially the same length and width as a length and width of the other semiconductor die 118, and the sides of all the dice 108 and 118 may be vertically aligned.", "FIG.", "5 is a cross-sectional view of still another embodiment of a semiconductor device package 142.The semiconductor device package 142 of FIG.", "5 may be generally similar to the semiconductor device package 100 of FIG.", "1, with specific differences described as follows.", "In some embodiments, the semiconductor device package 142 may lack any heat spreader 132 (see FIG.", "1) and TIM 136 (see FIG.", "1).", "For example, the inactive surface 122 of the other semiconductor die 118 may be exposed to the environment (e.g., to the air) on a side of the other semiconductor die 118 opposing the substrate 102.More specifically, the inactive surface 122 of the other semiconductor die 118 may at least partially define a topmost surface of the semiconductor device package 142.In some embodiments, an encapsulation material 144 may at least partially surround a periphery of the other semiconductor die 118.For example, encapsulation material 144 may extend around the periphery of the other semiconductor die 118, but may not extend onto the inactive surface 122 of the other semiconductor die 118.More specifically, the encapsulation material 144 may, for example, surround the periphery of the other semiconductor die 118 and be flush with the inactive surface 122 of the other semiconductor die 118.In some embodiments, the encapsulation material 144 may also at least partially surround other components of the semiconductor device package 142.For example, the encapsulation material 144 may at least partially surround each interposer 130, the stack of semiconductor dice 108 between the other semiconductor die 118 and the substrate 102, and the electrical conductors 124 electrically connecting the other semiconductor die 118 to each interposer 130.In some embodiments, the encapsulation material 144 may be dispensed, as by molding, in a single application and comprise an electrically insulating and thermally conductive material (e.g., exhibiting a thermal conductivity of about 0.5 W/m·K, 1 W/m·K, 1.5 W/m·K, 2 W/m·K, 2.5 W/m·K, 3 W/m·K or more, or in any range defined by such thermal conductivities).", "Suitable encapsulation materials 144 are commercially available, for example, from Sumitomo Plastics America, Inc. of Santa Clara, Calif.", "The semiconductor device package 142 may include one or more interposers 130 located between the other semiconductor die 118 and the substrate 102 laterally adjacent to the semiconductor dice 108 in the stack between the other semiconductor die 118 and the substrate 102.The interposer 130 may include one or more electrical connectors 128 extending through the interposer 130 and directly electrically connecting the active surface 120 of the other semiconductor die 118 to the substrate 102.For example, the interposer 130 may exhibit any of the configurations described previously in connection with FIGS.", "1 through 3.The semiconductor device package 142 may be assembled from the substrate 102 upward at the wafer or other bulk substrate level and then singulated to form the semiconductor device package 142 in some embodiments.", "For example, the stack of semiconductor dice 108 may be positioned on, and electrically connected to, a wafer including the substrate 102 utilizing the vias 110.The underfill material 116 may be positioned between each adjacent pair of semiconductor dice 108 and 118 one layer at a time, or in one step after the stack of the first semiconductor die 108 and the additional semiconductor dice 118 has been completed.", "Each interposer 130 may be positioned laterally adjacent to the stack of semiconductor dice 108 on the substrate 102, and may be electrically connected to the substrate 102.The other semiconductor die 118 may be positioned over, and electrically connected to, the electrical connectors 128 of each interposer 130 and the stack of semiconductor dice 108 with the active surface 120 of the other semiconductor die 118 facing the substrate 102.An encapsulation material 144 may be dispensed over the wafer including the substrate 102 and around the stack of semiconductor dice 108, each interposer 130, and the periphery of the other semiconductor die 118.The inactive surface 122 of the other semiconductor die 118 may remain exposed to the environment.", "The semiconductor device package 142 may then be singulated from the wafer (e.g., by cutting a plurality of such semiconductor device packages 142 arranged in a grid from the wafer).", "FIG.", "6 is a cross-sectional view of yet another embodiment of a semiconductor device package.", "The semiconductor device package 146 of FIG.", "6 may be generally similar to the semiconductor device package 142 of FIG.", "5, with specific differences described as follows.", "In some embodiments, the semiconductor device package 146 may lack any separate interposer 130 (see FIG.", "5) for directly electrically connecting the other semiconductor die 118 to the substrate 102.For example, the electrical connectors 128 may extend through portions of the semiconductor dice 108 in the stack between the other semiconductor die 118 and the substrate 102.More specifically, the electrical connectors 128 may extend, for example, through portions of the semiconductor dice 108 in the stack between the other semiconductor die 118 and the substrate 102 located laterally adjacent to the vias 110.As a specific, nonlimiting example, the electrical connectors 128 may extend through the semiconductor dice 108 in the stack between the other semiconductor die 118 and the substrate 102 at the peripheries thereof in portions lacking integrated circuitry.", "While certain illustrative embodiments have been described in connection with the figures, those of ordinary skill in the art will recognize and appreciate that the scope of this disclosure is not limited to those embodiments explicitly shown and described in this disclosure.", "Rather, many additions, deletions, and modifications to the embodiments described in this disclosure may be made to produce other embodiments within the scope of this disclosure, such as those specifically claimed, including legal equivalents.", "In addition, features from one disclosed embodiment may be combined with features of another disclosed embodiment while still being within the scope of this disclosure, as contemplated by the inventors." ] ]
Patent_15874406
[ [ "System and Process for Having Wireless Service Value Included in a SIM Card", "A method and system a system for activating a wireless service includes a subscriber identity module (SIM) card having a first surface, the SIM card including a subscriber identity module (SIM), and an activation code stored with the SIM card.", "The activation code is linked to the SIM.", "A wireless device configured to receive the SIM, where the SIM is configured to be utilized in the wireless device, the wireless device including: a memory that stores an operating system of the wireless device and a wireless service activation application, a processor that processes a function of the wireless device, a display that displays information to a user, the wireless service activation application is configured to capture the activation code that authorizes the wireless device on a wireless network and authorizes a predetermined amount of wireless service for the wireless device associated with said SIM." ], [ "1.A system for activating a wireless service, the system comprising: a subscriber identity module (SIM) card having a first surface; the SIM card comprising a subscriber identity module (SIM); and an activation code stored with the SIM card, the activation code is linked to said SIM, the activation code authorizes on a wireless network a predetermined amount of wireless service, the SIM is configured to be utilized in a wireless device, the wireless device comprising: a memory that stores an operating system of the wireless device and a wireless service activation application; a processor that processes a function of the wireless device; a display that displays information to a user, wherein the display includes a touch screen; the processor implements the wireless service activation application, the wireless service activation application is configured to capture the activation code from the SIM card that authorizes the wireless device on the wireless network and authorizes the predetermined amount of wireless service for the wireless device associated with said SIM; and a transceiver configured to transmit the activation code to a wireless network backend system to validate the activation code and provision the predetermined amount of wireless service; the system further comprising: the wireless network backend system configured to validate the activation code and provision the predetermined amount of wireless service; and an accounting unit configured to monitor the usage of the wireless service of the wireless device.", "2.The system of claim 1, wherein the wireless device further comprises a near field communication reader in communication with the processor, and wherein the SIM card also includes a near field communication tag storing the activation code.", "3.The system of claim 1, wherein the SIM card includes the activation code on the first surface; and wherein the wireless device further comprises a camera in communication with the processor, the camera configured to capture the activation code on said SIM card that authorizes the wireless device on the wireless network and authorizes the predetermined amount of wireless service.", "4.The system of claim 1, wherein the SIM electronically stores the activation code; and wherein the wireless device further implements the wireless service activation application to retrieve the activation code stored in said SIM that authorizes the wireless device on the wireless network and authorizes the predetermined amount of wireless service.", "5.The system of claim 1, wherein the SIM card includes the activation code on the first surface; and wherein the wireless device is further configured to implement the wireless service activation application to manually receive the activation code from the user that authorizes the wireless device on the wireless network and authorizes the predetermined amount of wireless service.", "6.The system of claim 5, wherein the activation code is a bar code.", "7.The system of claim 5, wherein the activation code is an alpha numeric code.", "8.The system of claim 1, wherein the accounting unit is further configured to determine if wireless service has been depleted and thereafter configured to control a usage of the wireless service.", "9.The system of claim 1, wherein the wireless network backend system includes a database that includes activation data that validates the activation code and allows the wireless service activation application to authorize the predetermined amount of wireless service of the wireless device using said SIM.", "10.A device for activating a wireless service, the device comprising: a subscriber identity module (SIM) card having a first surface; the SIM card comprising a subscriber identity module (SIM); and an activation code stored with the SIM card, the activation code is linked to said SIM, the activation code authorizes on a wireless network a predetermined amount of wireless service, wherein the SIM is configured to be utilized in a wireless device configured to receive the SIM, the wireless device comprising: a processor that processes a function of the wireless device; a display that displays information to a user, wherein the display includes a touch screen; the processor is configured to capture the activation code from the SIM card that authorizes the wireless device on the wireless network and authorizes the predetermined amount of wireless service for the wireless device associated with said SIM; and a transceiver configured to transmit the activation code to a wireless network backend system to validate the activation code and provision the predetermined amount of wireless service, the usage of the wireless service of the wireless device being monitored by an accounting unit.", "11.The device of claim 10, wherein the wireless device further comprises a near field communication reader in communication with the processor, and wherein the SIM card also includes a near field communication tag storing the activation code.", "12.The device of claim 10, wherein the SIM card includes the activation code on the first surface; and wherein the wireless device further comprises a camera in communication with the processor, the camera configured to capture the activation code on said SIM card that authorizes the wireless device on the wireless network and authorizes the predetermined amount of wireless service.", "13.The device of claim 10, wherein the SIM electronically stores the activation code; and wherein the wireless device further implements the wireless service activation application to retrieve the activation code stored in said SIM that authorizes the wireless device on the wireless network and authorizes the predetermined amount of wireless service.", "14.The device of claim 10, wherein the SIM card includes the activation code on the first surface; and wherein the wireless device is further configured to implement the wireless service activation application to manually receive the activation code from the user that authorizes the wireless device on the wireless network and authorizes the predetermined amount of wireless service.", "15.The device of claim 10, wherein the accounting unit is further configured to determine if wireless service has been depleted and thereafter configured to control a usage of the wireless service.", "16.A process for authorizing wireless service, the process comprising: providing a generally rectangular flat form factor card having a first surface and opposing second surface; providing a removable subscriber identity module (SIM) arranged in the generally rectangular flat form factor card defined by the first surface, wherein the at least one removable subscriber identity module (SIM) is releasably attached to the first surface of the generally rectangular flat form factor card; providing an activation code stored at least in one of the following: the removable subscriber identity module (SIM) and the generally rectangular flat form factor card, wherein the activation code is configured to authorize wireless service associated with the at least one removable subscriber identity module (SIM) when provided to a system associated with a wireless service provider; receiving the activation code in a wireless network backend system to validate the activation code and provision a predetermined amount of wireless service; provisioning the wireless service to a wireless device from a wireless network when the wireless device operates in conjunction with the at least one removable subscriber identity module (SIM) after the wireless network backend system validates the activation code and the activation code is provided to the system associated with the wireless network; and monitoring the usage of the wireless service of the wireless device by an accounting unit.", "17.The process of claim 16, further comprising providing the wireless device with a near field communication reader in communication with a processor of the wireless device, and wherein the SIM card also includes a near field communication tag storing the activation code.", "18.The process of claim 16, wherein the generally rectangular flat form factor card includes the activation code; and wherein the wireless device further comprises a camera in communication with a processor of the wireless device, the camera configured to capture the activation code on the generally rectangular flat form factor card that authorizes the wireless device on the wireless network and authorizes the predetermined amount of wireless service.", "19.The process of claim 16, wherein the SIM electronically stores the activation code; and wherein the wireless device further implements a wireless service activation application to retrieve the activation code stored in said SIM that authorizes the wireless device on the wireless network and authorizes the predetermined amount of wireless service.", "20.The process of claim 16, wherein the SIM card includes the activation code on the first surface; and wherein the wireless device is further configured to implement a wireless service activation application with a processor of the wireless device, the processor configured to manually receive the activation code from a user that authorizes the wireless device on the wireless network and authorizes the predetermined amount of wireless service." ], [ "<SOH> BACKGROUND OF THE DISCLOSURE <EOH>" ], [ "<SOH> SUMMARY OF THE DISCLOSURE <EOH>The foregoing needs are met, to a great extent, by the disclosure, providing a system and associated methods for activating services and subscriptions on wireless devices and/or systems implementing a SIM card having wireless service by.", "According to aspects of the disclosure, a system for activating a wireless service includes a subscriber identity module (SIM) card having a first surface, the SIM card including a subscriber identity module (SIM), and an activation code stored with the SIM card, the activation code is linked to said SIM, a wireless device configured to receive the SIM, where the SIM is configured to be utilized in the wireless device, the wireless device including: a memory that stores an operating system of the wireless device and a wireless service activation application, a processor that processes a function of the wireless device, a display that displays information to a user, where the display includes a touch screen, and the processor implements the wireless service activation application, the wireless service activation application is configured to capture the activation code that authorizes the wireless device on a wireless network and authorizes a predetermined amount of wireless service for the wireless device associated with said SIM.", "According to some additional aspects, a device for activating a wireless service includes a subscriber identity module (SIM) card having a first surface, the SIM card including a subscriber identity module (SIM), and an activation code stored with the SIM card, the activation code is linked to said SIM, where the SIM is configured to be utilized in a wireless device configured to receive the SIM, the wireless device including a memory that stores an operating system of the wireless device and a wireless service activation application, a processor that processes a function of the wireless device, a display that displays information to a user, where the display includes a touch screen, and the processor implements the wireless service activation application, the wireless service activation application is configured to capture the activation code that authorizes the wireless device on a wireless network and authorizes a predetermined amount of wireless service for the wireless device associated with said SIM.", "According to some additional aspects, a process for authorizing wireless service includes providing a generally rectangular flat form factor card having a first surface and opposing second surface, providing at least one removable subscriber identity module (SIM) arranged in the generally rectangular flat form factor card defined by the first surface, where the at least one removable subscriber identity module (SIM) is releasably attached to the first surface of the generally rectangular flat form factor card by respective breaking tabs, and providing an activation code stored at least in one of the following: the removable subscriber identity module (SIM) and the generally rectangular flat form factor card, where the activation code is configured to authorize wireless service associated with the at least one removable subscriber identity module (SIM) when provided to a system associated with a wireless service provider, and provisioning the wireless service to a wireless device from a wireless network when the wireless device operates in conjunction with the at least one removable subscriber identity module (SIM) and the activation code is provided to the system associated with the wireless network.", "There has thus been outlined, rather broadly, certain aspects of the disclosure in order that the detailed description thereof herein may be better understood, and in order that the present contribution to the art may be better appreciated.", "There are, of course, additional aspects of the disclosure that will be described below and which will also form the subject matter of the claims appended hereto.", "In this respect, before explaining at least one aspects of the disclosure in detail, it is to be understood that the disclosure is not limited in its application to the details of construction and to the arrangements of the components set forth in the following description or illustrated in the drawings.", "The disclosure is capable of aspects in addition to those described and of being practiced and carried out in various ways.", "Also, it is to be understood that the phraseology and terminology employed herein, as well as the abstract, are for the purpose of description and should not be regarded as limiting.", "As such those skilled in the art will appreciate that the conception upon which this disclosure is based may readily be utilized as a basis for the designing of other structures, methods and systems for carrying out the several purposes of the disclosure.", "It is important, therefore, that the claims be regarded as including such equivalent constructions insofar as they do not depart from the spirit and scope of the disclosure." ], [ "CROSS REFERENCE TO PRIOR APPLICATIONS This application is a continuation of the U.S. patent application Ser.", "No.", "15/089,919, filed Apr.", "4, 2016, now U.S. Pat.", "No.", "9,883,374 issued Jan. 30, 2018.This application further claims the benefit from U.S.", "Provisional Application No.", "62/150,614 filed on Apr.", "21, 2015.Both applications are hereby incorporated by reference for all purposes as if fully set forth herein.", "BACKGROUND OF THE DISCLOSURE 1.Field of the Disclosure The disclosure relates to a system for activating wireless services on wireless devices.", "More particularly, the disclosure relates to a SIM (subscriber identity module or subscriber identification module) card having built in wireless service value, a wireless service code and/or a wireless activation code.", "2.Related Art A large number of cellular wireless service plans exist for customers desiring wireless cellular services such as data, talk, and text messaging.", "Customers generally have the option of entering into a post-paid service, e.g., contract for a period of time, or a pre-paid, contract-free service.", "A Mobile Virtual Network Operator (MVNO) is a mobile operator that typically does not own its own frequency spectrum or have its own wireless network infrastructure.", "MVNOs negotiate and enter into business agreements with third party wireless carriers to purchase the right to use their networks for wireless services including volume of data and number of minutes/text messages used.", "MVNOs often implement activation cards, also known as airtime cards, for the sale and activation and/or addition of a wireless service, e.g.", "talk airtime, data, or text messaging.", "Activation cards generally include a unique code that may include a scratch off cover obscuring the unique code consisting of a long series of letters and numbers.", "Codes are correlated to a wireless service and are stored in a MVNO's database prior to distributing the activation card to a respective point-of-sale and reaching the customer.", "Once a card is sold to a user, the user must manually scratch off the covering of the code and manually enter the code into the phone or in a computer linked to the MVNO's database to activate the wireless service.", "In order to increase the customer base, MVNOs may provide a SIM card to be activated using an airtime card that is bundled with the SIM card.", "However, often times, the customer will discard the SIM card and simply use the airtime card to add more time to an existing SIM card.", "Additionally, a SIM card to be activated using an airtime card that is bundled with the SIM card may require the user to execute multiple steps to authorize wireless service which may be confusing or deter the user from adopting a wireless plan.", "Accordingly, there is a need for new and improved devices, processes, and systems that can be implemented for the activation of a wireless service.", "SUMMARY OF THE DISCLOSURE The foregoing needs are met, to a great extent, by the disclosure, providing a system and associated methods for activating services and subscriptions on wireless devices and/or systems implementing a SIM card having wireless service by.", "According to aspects of the disclosure, a system for activating a wireless service includes a subscriber identity module (SIM) card having a first surface, the SIM card including a subscriber identity module (SIM), and an activation code stored with the SIM card, the activation code is linked to said SIM, a wireless device configured to receive the SIM, where the SIM is configured to be utilized in the wireless device, the wireless device including: a memory that stores an operating system of the wireless device and a wireless service activation application, a processor that processes a function of the wireless device, a display that displays information to a user, where the display includes a touch screen, and the processor implements the wireless service activation application, the wireless service activation application is configured to capture the activation code that authorizes the wireless device on a wireless network and authorizes a predetermined amount of wireless service for the wireless device associated with said SIM.", "According to some additional aspects, a device for activating a wireless service includes a subscriber identity module (SIM) card having a first surface, the SIM card including a subscriber identity module (SIM), and an activation code stored with the SIM card, the activation code is linked to said SIM, where the SIM is configured to be utilized in a wireless device configured to receive the SIM, the wireless device including a memory that stores an operating system of the wireless device and a wireless service activation application, a processor that processes a function of the wireless device, a display that displays information to a user, where the display includes a touch screen, and the processor implements the wireless service activation application, the wireless service activation application is configured to capture the activation code that authorizes the wireless device on a wireless network and authorizes a predetermined amount of wireless service for the wireless device associated with said SIM.", "According to some additional aspects, a process for authorizing wireless service includes providing a generally rectangular flat form factor card having a first surface and opposing second surface, providing at least one removable subscriber identity module (SIM) arranged in the generally rectangular flat form factor card defined by the first surface, where the at least one removable subscriber identity module (SIM) is releasably attached to the first surface of the generally rectangular flat form factor card by respective breaking tabs, and providing an activation code stored at least in one of the following: the removable subscriber identity module (SIM) and the generally rectangular flat form factor card, where the activation code is configured to authorize wireless service associated with the at least one removable subscriber identity module (SIM) when provided to a system associated with a wireless service provider, and provisioning the wireless service to a wireless device from a wireless network when the wireless device operates in conjunction with the at least one removable subscriber identity module (SIM) and the activation code is provided to the system associated with the wireless network.", "There has thus been outlined, rather broadly, certain aspects of the disclosure in order that the detailed description thereof herein may be better understood, and in order that the present contribution to the art may be better appreciated.", "There are, of course, additional aspects of the disclosure that will be described below and which will also form the subject matter of the claims appended hereto.", "In this respect, before explaining at least one aspects of the disclosure in detail, it is to be understood that the disclosure is not limited in its application to the details of construction and to the arrangements of the components set forth in the following description or illustrated in the drawings.", "The disclosure is capable of aspects in addition to those described and of being practiced and carried out in various ways.", "Also, it is to be understood that the phraseology and terminology employed herein, as well as the abstract, are for the purpose of description and should not be regarded as limiting.", "As such those skilled in the art will appreciate that the conception upon which this disclosure is based may readily be utilized as a basis for the designing of other structures, methods and systems for carrying out the several purposes of the disclosure.", "It is important, therefore, that the claims be regarded as including such equivalent constructions insofar as they do not depart from the spirit and scope of the disclosure.", "BRIEF DESCRIPTION OF THE DRAWINGS The above mentioned features and aspects of the disclosure will become more apparent with reference to the following description taken in conjunction with the accompanying drawings wherein like reference numerals denote like elements and in which: FIG.", "1 illustrates a block diagram of exemplary components of a wireless device in accordance with aspects of the disclosure.", "FIG.", "2A illustrates an exemplary wireless device with a display of a home screen on a graphical user interface and FIG.", "2B illustrates a subsequent screen showing a wireless service activation application on a graphical user interface, both of which may be used for the selection and control of the activation of a wireless service in accordance with an aspect of the disclosure.", "FIG.", "3A illustrates a SIM card used for activation of a wireless service.", "FIG.", "3B illustrates a SIM card with a near field communication tag that can be used according to aspects of the disclosure.", "FIG.", "4 illustrates a schematic diagram of an exemplary wireless service activation system in accordance with aspects of the disclosure.", "FIG.", "5 illustrates exemplary method steps which may be used to implement the system of the disclosure.", "DETAILED DESCRIPTION In this specification and claims it is to be understood that reference to a “wireless device” is intended to encompass any compatible computing device that can connect to a wireless communication network, such as mobile phones, personal computers, PDAs, tablet computers, gaming systems, MP3 players, mobile equipment, mobile stations, cellular phones, smartphones, handsets, (e.g., Apple iPhone, Google Android, Microsoft Windows or Blackberry based devices, other types of PDAs or smartphones), wireless dongles, or other mobile computing devices and the like.", "The term “wireless device” may be interchangeably used and referred to herein as “wireless handset,” “handset,” “mobile device,” “device,” “mobile phones,” “mobile equipment,” “mobile station,” “user equipment,” “cellular phone,” “smartphones,” or “phone.” A “point-of-sale” as used herein can refer to a location where one or more wireless devices and/or services can be sold and/or activated which may or may not require sales personnel.", "A point-of-sale can include, for example, a vending machine, an automated kiosk, a retailer store, a kiosk in a mall, a gas station, a convenient store, a web site, and such.", "Wireless devices may connect to a “wireless network” or “network” and are intended to encompass any type of wireless network to obtain or provide mobile phone services through the use of a wireless device, such as the Global System for Mobile Communication (GSM) network, Code-Division Multiple Access (CDMA) network, Long-Term Evolution (LTE) network, 5G (fifth generation) network, and/or a communication channel as defined herein, that may utilize the teachings of the present application to sell, activate, monitor, redeem, and/or track, the activation of one or more wireless services.", "Reference in this specification to “one aspect,” “an aspect,” “other aspects,” “one or more aspects” or the like means that a particular feature, structure, or characteristic described in connection with the aspect is included in at least one aspect of the disclosure.", "The appearances of, for example, the phrase “in one aspect” in various places in the specification are not necessarily all referring to the same aspect, nor are separate or alternative aspects mutually exclusive of other aspects.", "Moreover, various features are described which may be exhibited by some aspects and not by others.", "Similarly, various requirements are described which may be requirements for some aspects but not for other aspects.", "Referring now to FIG.", "1, a block diagram with exemplary components of a wireless device 100 in accordance with aspects of the disclosure is shown.", "In particular, the exemplary components which include a near field communication interface 134, e.g., reader or scanner, which may be used in conjunction with one or more near field communication tag(s) (shown in FIG.", "3B) during the distribution, verification, and/or sale/purchase, of a wireless service.", "Other uses of the near field communication interface 134 for the activation of a wireless service can include, but are not limited to, a change of phone settings, an activation message (e.g.", "text message) to be created and sent and ultimately received back, starting of an application (e.g.", "payment application), and the like.", "In addition, the wireless device 100 can include a power supply 128 in the form of a battery and a camera 138 that is multifunctional.", "The camera may be used to capture images such as of a person or place, biometric readings such as a fingerprint or a retina, letter, symbols, and numbers (optical character reading), image of a bar code such as QR code, and the like.", "The camera 138 may be on the front, back, sides and the like of the wireless device 100.The near field communication interface 134 and the camera 138 can be in communication with a processor 102, memory 104, and a user interface 120.The processor 102 may be a central processing unit configured to execute instructions such as instructions related to software programs.", "Any processor such as a FPGA, an ASIC, a microprocessor, a controller, and the like can be used for the wireless device 100 as understood to those of ordinary skill in the art.", "The display 118 may be a liquid crystal display (LCD), LED (light emitting diodes), OLED, and the like.", "Preferably the LCD includes a backlight to illuminate the various color liquid crystals to provide a more colorful display.", "The user interface 120 may be any type of physical input as readily employed in the field.", "For example, the user interface 120 may have physical buttons having alphanumeric labels thereon that can be used to enter a sequence of numbers, letters, symbols, or a combination thereof.", "Alternatively, the user interface 120 may be implemented on a touchscreen 122, a motion sensor (not shown), and the like.", "The memory 104 of the wireless device 100 may further include an operating system 106 (Windows, Apple IOS, Google Droid, etc.", "), a communication component 108, a contact/motion component 110, a graphics component 112, a wireless service activation application 114, a database 116, and the like.", "The operating system 106 together with the various components provides software functionality for each of the components of the wireless device 100.The memory 104 may include a high-speed, random-access memory.", "Also, the memory 104 may be a non-volatile memory, such as magnetic fixed disk storage, SIM, UICC, cloud-based memory, flash memory or the like.", "These various components may be connected through various communication lines including a data bus 136.The wireless device 100 can include an audio input/output device 126.The audio input/output device 126 may include speakers, speaker outputs, and the like, providing sound output; and may include microphones, microphone inputs, and the like, for receiving sound inputs.", "In an exemplary aspect, the audio input/output device 126 may include an analog to digital converter and a digital to audio converter for audio input and output functions, respectively.", "In another aspect, the wireless device 100 may include a transceiver 132 that provides radio and signal processing as needed to access a wireless network for services.", "The processor 102 may be configured to process call functions, data transfer, and the like and provide an array of services, based on those functions, to the user.", "In an exemplary aspect, the touchscreen 122 of the disclosure may be implemented in the display 118 (entire or a portion thereof) or separate from the display, and may detect a presence and location of a touch of finger or hand of a user within the display area.", "The touchscreen 122 may also sense other passive objects, such as a stylus and/or, in some aspects, for example, the touchscreen 122 may serve as the near field communication interface 134 when the near field communication tag(s) include a conductive component.", "The touchscreen 122 may be controlled by a touchscreen controller 130.In one operation, the display 118 may show various objects 124 associated with applications for execution by the processor 102.For example, a user may touch the display 118, particularly the touchscreen 122, to interact with the objects 124.That is, touching an object 124 may execute an application stored in the memory 104 by the processor 102 and associated with the object 124.Additionally or alternatively, touching an object 124 may open a menu of options to be selected by the user.", "The display 118 may include one or a plurality of objects 124 for the user to interact with.", "Moreover, the display 118 may include a plurality of screens and show one or more screens at a time.", "The user may interact with the display 118 to move a screen into view on the display 118.Various objects 124 may be located in each of the screens.", "The touchscreen 122 may be implemented as a resistive touchscreen, a surface acoustic wave touch screen, a capacitive touchscreen, self-capacitance sensors, infrared sensors, dispersive signal technology, acoustic pulse recognition, or the like.", "As previously mentioned, the touchscreen 122 can function as the near field communication interface 134 when conductive near field communication tags are implemented according to aspects of the present disclosure.", "The display 118 is generally configured to display a graphical user interface (GUI) 120 that provides an easy to use visual interface between a user of the wireless device 100 and the operating system 106 or application(s) running on the wireless device 100.Generally, the GUI presents programs, files and operational options with graphical images.", "During operation, the user may select and activate various graphical images displayed on the display 118 in order to initiate functions and tasks associated therewith.", "In another aspect of the disclosure, the memory 104 of a wireless device 100 can include the database 116 for storing user information and activation codes (valid and not used, currently used, previously used) or information.", "The user information may include full name, address, email address, contact number, credit card information, and the like.", "In one aspect, the database 116 may include security questions.", "In another aspect, the database 116 may include user specified preferences.", "In yet another aspect of the application, the memory 104 of a wireless device 100 can include a wireless service activation application 114.The application 114 may be preinstalled or downloaded from an application store (Android Store, Blackberry Store, Windows Store or Apple iTunes and the like).", "In another aspect, the application 114 can be installed in a memory a SIM 301, 351 of a SIM card 300, 350 (FIGS.", "3A and 3B) and is installed manually or automatically when the SIM 301, 351 of the SIM card 300, 350 is inserted into the wireless device 100.Upon installation, the air time activation code can also be retrieved as it can be embedded or stored in the memory of the SIM 301, 351 of the SIM card 300, 350 along with the application 114.The wireless service activation application 114 may be configured to control use of the wireless device 100 based on interaction with a wireless provider backend system 422 (shown in FIG.", "4) and/or one or more near field communication tag(s) (shown in FIG.", "3B) and/or an activation code, such as a bar code or an alpha numeric code, for the activation of a wireless service.", "The wireless service activation application 114 may utilize an internal accounting module to establish an account with a representation of prepaid funds or available credit for wireless services.", "In some aspects, the internal accounting module of the wireless service activation application 114 may also be used to store and/or transmit a plurality of charge rates as well as a billing/payment algorithm.", "The internal accounting module can classify each wireless service (data, voice, SMS) into one of a plurality of billing categories; receive data correlated to the near field communication tag(s) identifier or activation code (entered or captured by the camera, for example), select a charge rate corresponding to that billing category; calculate an appropriate charge for the data usage, voice usage, and SMS usage in real time by using the selected charge rate; and apply this appropriate charge to the account.", "For example, upon the retrieval and/or verification of a unique identifier of a near field communication tag by the near field communication interface 134 or an activation code captured by the camera 138, entered via the user interface 120, or automatically retrieved from the SIM 301, 351 of the SIM card 300, 350, the one or more steps may automatically take place to apply an appropriate charge or credit to the account.", "In some aspects, once the internal accounting module determines that the amount of wireless service (data, voice, SMS) used has depleted the account to zero or a predetermined amount, the processor 102 may interact with the internal accounting module and/or the wireless provider backend system 422 to limit, prevent, alert the user, and/or control further use of the wireless device 100 as further described herein.", "The controlled use can include suspending voice calls, allowing limited voice calls, allowing all voice calls, suspending text messages, allowing limited text messages, allowing all text messages, suspending wireless data service, limiting wireless data service, throttling wireless data service, and allowing all wireless data service.", "In this aspect, the wireless service activation application 114 may also include a module for one or more system provider host processors, which store wireless device identification information; store operating codes needed for wireless device activation; and store operating codes needed for setting prepaid funds or available credit amounts in wireless device accounts whereby, upon receipt of wireless device identification information from a near field communication tag or an activation code, the host processor may be capable of ascertaining the operating codes needed to activate that particular wireless device or needed to set its account amount.", "The internal accounting module may also be implemented partially in the wireless device 100 and in a wireless network as disclosed in U.S. Pat.", "No.", "8,805,323, entitled Hybrid network based metering server and tracking client for wireless services, issued Aug. 12, 2014, and incorporated herein by reference in its entirety.", "Moreover, the internal accounting module may be located entirely in the wireless network and provide functionality consistent as noted above.", "FIG.", "2A illustrates an exemplary wireless device 100 with a display of a home screen 200 and FIG.", "2B a subsequent screen 250 of a wireless service activation application 114 with a graphical user interface on a display 118, both which may be used for the selection and control of the activation of a wireless service in accordance with an aspect of the disclosure.", "The home screen 200 may include a plurality of objects 124 in the form of icons, and is not limited to a calling icon, texting icon, internet icon, and the like, allowing a user to perform one or more functions on the wireless device 100.For example, the home screen 200 may also display the icons 124 for one or more applications that have been downloaded from the Internet or pre-installed, and unlocked/retrieved using one or more near field communication tag(s) or an activation code.", "In some aspects, an application such as Google Wallet™, Google Play™, Android Market™, Apple Store™, or the like, may also function with the one or more near field communication tag(s) or activation code to process or credit a payment or redeem a credit (contest give away), add or redeem gift card value, add or redeem coupons or other data during the activation of one or more selected wireless service.", "As shown in FIG.", "2B, the wireless service activation application 114 may provide numerous ways in which to receive an activation code.", "At input 202, a user may indicate that they want to manually enter the activation code.", "At input 204, a user may indicate that they want to retrieve the activation code from the SIM.", "At input 206, a user may indicate that they want to capture the activation code with the camera.", "At input 208, a user may indicate that they want to capture the activation code with the near field communication interface 134.Some of the payment and/or authentication applications may be stored in a robust manner that prevents a user from deleting, modifying, tampering, and the like, with the application's functionality.", "In this regard, the wireless service activation application 114, for example, can provide data management information, as depicted in subsequent screen 250, but may not allow or limit user's input for the activation and/or control of the wireless services.", "Further, in some aspects the provision of the options depicted in the subsequent screen 250 to the user may only be made available during activation of a wireless service and verification of a unique identifier of a near field communication tag or the activation code.", "Referring now to FIG.", "3A, the SIM card 300 used for authentication of wireless device 100 on a wireless service is depicted.", "As customers often own their wireless device 100, they may need the SIM card 300 in order to authenticate the wireless device 100 on a particular wireless service provider (mobile network operator (MNO) such as Verizon, AT&T, Sprint, T-Mobile, etc.", "or a MVNO).", "The SIM card 300 may be sold individually or in a multipack and may be available at various locations.", "The SIM card 300 may be a generally rectangular flat form factor card having a first surface and opposing second surface.", "The SIM card 300 may include at least one removable subscriber identity module (SIM) 301 arranged in the generally rectangular flat form factor card defined by the first surface.", "The SIM 301 may be releasably attached to the first surface of the generally rectangular flat form factor of the SIM card 300 by respective breaking tabs.", "In an aspect of the disclosure, the SIM card 300 may include the activation code 305 in the form of a series of number as shown or a series of numbers, letters, symbols or a combination thereof.", "The activation code 305 may be included on a SIM card 300 or the activation code 305 may be included in a memory of the SIM 301 initially held by the SIM card 300.The activation code 305 may be included on the SIM card 300.In order to entice new customers to activate a wireless device 100, the SIM card 300 may be part of a contest, a give-away, a discounted purchase, or a purchase.", "The activation code 305 may be located under a scratch-off panel and can be manually entered into the wireless device 100 using the user interface 120, automatically retrieved from the memory of the SIM 301, automatically retrieved as it was part of the application 114 or captured as an image with the camera 138.The activation code 305 can be pre-paid amount of wireless service or includes a predetermined amount of wireless credit (as part of winning a contest) for one of more wireless services.", "The activation code 305 can be unique to one SIM card or can be shared by SIMS in multiple packs.", "By sharing, this allows additional SIM card activations and thus, new customers for the MVNOs.", "In another aspect, a bar code 315 may be used as an alternative or in addition to the activation code 305.The bar code 315 can include the same series of numbers, letters, symbols or a combination thereof that are similar to the activation code 305.The bar code 315 can be scanned using the camera 138, alternatively a bar code reader (not shown) that can be attached to the wireless device 100, or the like.", "Both the activation code 305 and the bar code 315 have previously been recorded and correlated to a predetermined amount of credit for a particular wireless service/wireless services, in a backend system's database.", "Further, both the activation code 305 and the bar code 315 can include credit for all services such as talk, text and data or can be limited to one or any combination thereof as desired.", "Further, the SIM card 300 may include an advertisement portion 310 that shows the wireless service provider and the specific amount of data and/or time being provided.", "In addition or alternatively, other types of advertisement, such as third party logos may be included in the advertisement portion 310.Referring now to FIG.", "3B, a SIM card 350 having a near field communication tag 360 according to aspects of the present disclosure is illustrated.", "In some aspects, more than one near field communication tag 360 can be included in the SIM card 350.The SIM card 350 may include a SIM 351.The near field communication tag 360 may have either read only data capability or may have rewriteable data capability.", "As such, configurability, memory, security, data retention and write endurance, may all vary according to the activation application.", "The variations of the near field communication tags included and the number of tags which can be utilized to streamline the wireless service activation process, provide a more secure sale and activation process, provide for less data storage in backend databases, post distribution programmability of the airtime cards, and eliminate point-of-sale requirements.", "The SIM card 350 may be a generally rectangular flat form factor card having a first surface and opposing second surface.", "The SIM card 350 may include at least one removable subscriber identity module (SIM) 351 arranged in the generally rectangular flat form factor card defined by the first surface.", "The SIM 351 may be releasably attached to the first surface of the generally rectangular flat form factor of the SIM card 350 by respective breaking tabs.", "According to some aspects of the disclosure, a near field communication equipped wireless device 100, e.g.", "smart phone, can be paired with the near field communication tag 360 to automate a task including, for example, a change in phone settings, a text to be created and sent, an application to be launched, or any number of commands to be executed, for the purchase/sale, payment, activation of a wireless service, and/or monitoring of wireless services sold/authorized.", "These automated tasks may also be performed based on the activation code 305 or bar code 315.The SIM card 350 may also include a generic label 355 that can advertise similar or different information as advertisement portion 310.This may be achieved when using a reprogrammable near field communication tag 360 which can be programmed at a store or a kiosk, for example.", "Further, by simply bringing the near field communication enabled wireless device to a distance of 10 cm or less, the activation and/or purchase of wireless services can be automated and streamlined.", "For example, quicker verification of codes can result since the system is more secure and the need of storing all unique codes and correlated services on a backend system's database prior to distribution is eliminated.", "Referring now to FIG.", "4, a schematic diagram of an exemplary wireless service activation system according to aspects of the disclosure is depicted.", "In particular, the wireless service activation system 400 can be used to activate wireless network service(s) on a wireless device 100 implementing various aspects of the SIM card activation using the disclosed code and/or near field communication systems.", "Unlike conventional activation processes for wireless devices that can require a user 412 to contact a live customer service representative, utilize an interactive voice response system from a landline or another wireless device, manually input the code, or access an Internet website by the user 412 to use a website activation system, the present wireless service activation system 400 can be used to activate a wireless device 414, such as the wireless device 100, and/or activate services with automated code/information gathering and without requiring access to an agent, a website, or the like.", "According to aspects of the disclosure, the activated service(s) may include, for example, activation of a wireless service after or during the initial activation of the wireless device 100 by a user 412.The initial activation of the wireless device 414, such as the wireless device 100, may be described herein as “out of the box” activation and may take place at the point-of-sale 420, which may have a contest give away.", "Alternatively, the contest give away may be independent of the point-of-sale 420, such as via mail, or at special events (concerts, contest sites, parties, and the like).", "In some additional aspects, the services requested to be activated and authorized are one or combinations of: airtime, text messaging, and data plans, but may also include at least one of device upgrades, device reactivations, wireless number changes, and wireless number porting for wireless devices that have previously been activated.", "According to some aspects of the disclosure, the point-of-sale 420 can include, for example, a store retailer, a vending machine, a kiosk, and the like.", "The contest give away can provide winning contestants with the SIM card 300 or SIM card 350 depending on the desired activation.", "In an aspect of the disclosure, the SIM card 300 and SIM card 350 may both include the activation code 305 and the near field communication tag 360.When the contestant or user is ready to activate the SIM card 300, he can simply enter the activation code 305 into the wireless device 100 using the user interface 120.Alternatively, the activation code 305 stored in the memory of the SIM 301 may be retrieved by the wireless device 100.Alternatively, the user can take a picture of the activation code 305 or scan the bar code 315 using the camera 138.Then the user inserts the SIM card 300 into the wireless device 100.Then through the user interface 120 or touchscreen 122, the user 412 can activate the wireless device 100 using the wireless service activation application 114.The SIM card 300 can be configured to solely communicate with a wireless network provider using limited data communication even though the SIM card 300 has not been permanently authenticated.", "In one aspect, the wireless service activation application 114 communicates with the wireless provider backend system 422 through a cell tower 416.Then the wireless provider backend system 422 authenticates (permanently) the SIM card 300 and authorizes the predetermined number of talk time, text, or data or a combination thereof based on the activation code 305 or the code stored on bar code 315.Alternatively, the wireless provider backend system 422 may also include an interface with other authentication or payment services such as Google Wallet™, Google Play™, Android Market™, Apple Store™, or the like.", "Additionally, the wireless service activation application 114 can simply request the user to enter his ZIP Code or use the built in global navigation system (GNSS) in the wireless device 100 in order to authorize and activate the SIM card 300, 350 based on location or billing area.", "It should be noted, that regardless of the method of authentication and authorization by activation code 305, the bar code 315 and/or the near field communication tag 360, the contestant can't simply use the activation code to add additional services (talk time, text, and/or data) to a different SIM card other than to the SIM card that the activation code is linked to.", "Additionally, the amount or type of services preauthorized by the activation code may be valid on a single SIM card or multiple SIM cards.", "In another aspect, the wireless service activation application 114 can simply access the database 116 stored on the wireless device 100 in order to authenticate and authorize the SIM 301, 351 of the SIM card 300 or SIM card 350.The database 116 can be previously stored on the wireless device 100 and can be supplemented via access to the wireless provider backend system 422 or simply downloaded at the time of activation.", "The point-of-sale 420 may also include a near field communication system 425 that can be used for payment and/or executing security and activation protocols using one or more near field communication tag(s) 360.Further, the near field communication system 425 at the point-of-sale 420 can be configured to communicate with the near field communication tag 360 and in some aspects the wireless device 100, which may also be configured to be in communication with the wireless provider backend system 422.In one aspect, the wireless provider backend system 422 may be implemented as a server.", "Communication with the wireless device 100 may include, for example, one or more of: communication using the wireless device's near field communication interface 134, a wire connector, a data messaging channel, such as an Unstructured Supplementary Service Data (USSD) channel, a Short Message Service (SMS) messaging channel or a Wireless Application Protocol (WAP) messaging channel, a personal area network (PAN), such as a Bluetooth™ communication, an induction wireless communication, an infrared wireless communication, an ultra-wideband communication, a ZigBee™ communication, a wireless fidelity communication channel, a local area network (LAN), and/or a communication channel as defined herein.", "Communication between the near field communication system 425 of the point-of-sale 420 and the wireless device 100 may be used to transmit a payment or redeem a credit for a wireless service and/or automatically retrieve and/or generate wireless device-related information based on a user's input selection.", "According to some aspects of the present disclosure, the wireless service selection can be made by scanning a near field communication tag 360 of the SIM card 350 using the near field communication interface 134 of the wireless device 100, and can include a wireless provider selection, and/or a wireless service type and amount to be activated.", "In some aspects, the near field communication tag 360 can further be scanned by the near field communication system 425 at the point-of-sale 420, for example, for verification, authorization, and/or security encryption.", "The wireless service selection, near field communication tag 360 unique identifier, and wireless device 100 related information may be transferred to a wireless provider backend system 422.The wireless device-related information can include, for example, the International Mobile Station Equipment Identify (“IMEI”), an Electronic Serial Number (ESN), Mobile Equipment Identifier (MEID), and/or a serial number for a subscriber identity module (SIM) card installed in the wireless device 100.The SIM card 300, 350 may include a SIM card memory for storing at least a SIM card serial number, for example, an Integrated Circuit Card ID (ICCID).", "A wireless device 100 not utilizing a SIM card is contemplated as well for use with the disclosure.", "In some aspects, the information transferred may be in the form of an activation message that corresponds and/or includes the wireless provider and/or wireless service selection by the user 412 and automatically retrieved wireless device related information, the near field communication tag 360 unique identifier, and/or payment/authorization verification from the point-of-sale 420.The activation message including the automatically retrieved information can be generated by a processor including, for example, the processor of the wireless device 100 and/or a processor at the point-of-sale 420.In some aspects, the activation message may be transmitted over a provisioning channel provided over a cell tower 416 that is available to inactive or unprovisioned wireless devices or via any type of conventional activation protocols known in the art.", "Alternatively, the activation message can be transmitted from the point-of-sale 420 via any wired or other wireless communication type to the wireless provider backend system 422.The wireless provider backend system 422 can include one or more databases wherein authorized unique identifiers of a near field communication tag 360 may be correlated/recorded when a wireless service is redeemed and/or purchased.", "Referring now to FIG.", "5, exemplary method steps, which may be used to implement systems of the disclosure, are depicted in a flowchart 500.In particular, the method steps include ways in which a user can provide an activation code located on the SIM card 300, 350 to activate one or more wireless service(s) on the wireless device 100.At step 502, the user provides an activation code 305 in the form of a code (letters, numbers, symbols or combination thereof) that was captured by the camera 138, manually entered using the user interface 120, a bar code 315 captured by the camera 138, a near field communication tag 360 using the near field communication interface 134, or stored electronically in the SIM 301.The activation code may include a programmed identifier that can correspond to a wireless provider selection and one or more wireless service to be activated.", "For example, the identifier may include a first code corresponding to a wireless provider, followed by a second code corresponding to a wireless service type, and followed by a third code corresponding to an amount that is being redeemed.", "It is contemplated that additional codes may be included for additional services and amounts, security codes, as well as for production data for statistical analysis performed by the wireless provider, as it may be desired.", "Each of the codes may be a series of digits including letters, symbols, and/or numbers.", "At step 504, activation code 305 can be received by the wireless device 100, or the near field communication interface 134 and/or the near field communication system 425 at the point-of-sale 420.If received by the wireless device 100 and/or the near field communication interface 134, then the wireless device can transmit the activation code to the cell tower 416, which then relays the code to the wireless provider backend system 422 for authentication.", "If the activation code is received by near field communication system 425 at the point-of-sale 420, then the activation code is sent to the wireless provider backend system 422 for authentication.", "At step 508, the activation code 305, the bar code 315, or the near field communication tag 360 codes along with wireless device 100 information are received by the wireless provider backend system 422 where it can verify the authentication code by searching one or more databases.", "Alternatively, the database can be preloaded with information relating to the wireless device 100 and the activation code 305 is authenticated by the wireless device 100 through the wireless service activation application.", "In one aspect, prior to sending the activation code 305, the bar code 315 or the near field communication tag 360 to the wireless provider backend system 422, a text message containing temporary log in information may be sent to the wireless device for use by the wireless service activation application to log into the wireless provider backend system 422.At step 510, if the activation code is not valid, the activation of the wireless service will be stopped at step 512.Upon stopping the activation 512 of the wireless service, the wireless provider backend system 422 may send a warning message to the user 412 (e.g., using the wireless device 100) and/or the wireless provider and proceed back to step 502 and wait for the valid authentication code to be provided.", "At step 514, if the activation code is valid (authentic, not been previously used, or the like), authorization of a wireless service may take place at step 516.At step 518, the use of the activated wireless service may be monitored to determine when the activated wireless service has been depleted by the user 412.At step 520 the process ends.", "Aspects of the disclosure may include communication channels that may be any type of wired or wireless electronic communications network, such as, e.g., a wired/wireless local area network (LAN), a wired/wireless personal area network (PAN), a wired/wireless home area network (HAN), a wired/wireless wide area network (WAN), a campus network, a metropolitan network, an enterprise private network, a virtual private network (VPN), an internetwork, a backbone network (BBN), a global area network (GAN), the Internet, an intranet, an extranet, an overlay network, Near field communication (NFC), a cellular telephone network, a Personal Communications Service (PCS), using known protocols such as the Global System for Mobile Communications (GSM), CDMA (Code-Division Multiple Access), GSM/EDGE and UMTS/HSPA network technologies, Long Term Evolution (LTE), 5G (5th generation mobile networks or 5th generation wireless systems), WiMAX, HSPA+, W-CDMA (Wideband Code-Division Multiple Access), CDMA2000 (also known as C2K or IMT Multi-Carrier (IMT-MC)), Wireless Fidelity (Wi-Fi), Bluetooth, and/or the like, and/or a combination of two or more thereof.", "The NFC standards cover communications protocols and data exchange formats, and are based on existing radio-frequency identification (RFID) standards including ISO/IEC 14443 and FeliCa.", "The standards include ISO/IEC 18092[3] and those defined by the NFC Forum.", "Aspects of the disclosure may be implemented in any type of computing devices, such as, e.g., a desktop computer, personal computer, a laptop/mobile computer, a personal data assistant (PDA), a mobile phone, a tablet computer, cloud computing device, and the like, with wired/wireless communications capabilities via the communication channels.", "Aspects of the disclosure may be implemented in any type of mobile smartphones that are operated by any type of advanced mobile data processing and communication operating system, such as, e.g., an Apple™ iOS™ operating system, a Google™ Android™ operating system, a RIM™ Blackberry™ operating system, a Nokia™ Symbian™ operating system, a Microsoft™ Windows Mobile™ operating system, a Microsoft™ Windows Phone™ operating system, a Linux™ operating system or the like.", "Further in accordance with various aspects of the disclosure, the methods described herein are intended for operation with dedicated hardware implementations including, but not limited to, PCs, PDAs, semiconductors, application specific integrated circuits (ASIC), programmable logic arrays, cloud computing devices, and other hardware devices constructed to implement the methods described herein.", "It should also be noted that the software implementations of the disclosure as described herein are optionally stored on a tangible storage medium, such as: a magnetic medium such as a disk or tape; a magneto-optical or optical medium such as a disk; or a solid state medium such as a memory card or other package that houses one or more read-only (non-volatile) memories, random access memories, or other re-writable (volatile) memories.", "A digital file attachment to email or other self-contained information archive or set of archives is considered a distribution medium equivalent to a tangible storage medium.", "Accordingly, the disclosure is considered to include a tangible storage medium or distribution medium, as listed herein and including art-recognized equivalents and successor media, in which the software implementations herein are stored.", "Additionally, the various aspects of the disclosure may be implemented in a non-generic computer implementation.", "Moreover, the various aspects of the disclosure set forth herein improve the functioning of the system as is apparent from the disclosure hereof.", "Furthermore, the various aspects of the disclosure involve computer hardware that it specifically programmed to solve the complex problem addressed by the disclosure.", "Accordingly, the various aspects of the disclosure improve the functioning of the system overall in its specific implementation to perform the process set forth by the disclosure and as defined by the claims.", "According to an example, the global navigation satellite system (GNSS) may include a device and/or system that may estimate its location based, at least in part, on signals received from space vehicles (SVs).", "In particular, such a device and/or system may obtain “pseudorange” measurements including approximations of distances between associated SVs and a navigation satellite receiver.", "In a particular example, such a pseudorange may be determined at a receiver that is capable of processing signals from one or more SVs as part of a Satellite Positioning System (SPS).", "Such an SPS may comprise, for example, a Global Positioning System (GPS), Galileo, Glonass, to name a few, or any SPS developed in the future.", "To determine its location, a satellite navigation receiver may obtain pseudorange measurements to three or more satellites as well as their positions at time of transmitting.", "Knowing the SV orbital parameters, these positions can be calculated for any point in time.", "A pseudorange measurement may then be determined based, at least in part, on the time a signal travels from an SV to the receiver, multiplied by the speed of light.", "While techniques described herein may be provided as implementations of location determination in GPS and/or Galileo types of SPS as specific illustrations according to particular examples, it should be understood that these techniques may also apply to other types of SPS, and that claimed subject matter is not limited in this respect.", "Aspects of the disclosure may include a server executing an instance of an application or software configured to accept requests from a client and giving responses accordingly.", "The server may run on any computer including dedicated computers.", "The computer may include at least one processing element, typically a central processing unit (CPU), and some form of memory.", "The processing element may carry out arithmetic and logic operations, and a sequencing and control unit may change the order of operations in response to stored information.", "The server may include peripheral devices that may allow information to be retrieved from an external source, and the result of operations saved and retrieved.", "The server may operate within a client-server architecture.", "The server may perform some tasks on behalf of clients.", "The clients may connect to the server through the network on a communication channel as defined herein.", "The server may use memory with error detection and correction, redundant disks, redundant power supplies and so on.", "The SIM 301 and SIM 351 may be an integrated circuit chip that is intended to securely store the international mobile subscriber identity (IMSI) number and its related key, which are used to identify and authenticate subscribers on mobile telephony devices (such as mobile phones and computers).", "The SIM 301 and SIM 351 may include a SIM circuit that may be part of the function of a Universal Integrated Circuit Card (UICC) physical smart card, which may be made of PVC with embedded contacts and semiconductors.", "The SIM 301 and SIM 351 may contain a unique serial number (ICCID), international mobile subscriber identity (IMSI) number, security authentication and ciphering information, temporary information related to the local network, a list of the services the user has access to, and the like.", "The SIM 301 and SIM 351 may store network-specific information used to authenticate and identify subscribers on the network.", "For example, the ICCID, IMSI, Authentication Key (Ki), Local Area Identity (LAI) and Operator-Specific Emergency Number.", "The SIM 301 and SIM 351 may store other carrier-specific data such as the SMSC (Short Message Service Center) number, Service Provider Name (SPN), Service Dialing Numbers (SDN), Advice-Of-Charge parameters and Value Added Service (VAS) applications.", "The many features and advantages of the disclosure are apparent from the detailed specification, and, thus, it is intended by the appended claims to cover all such features and advantages of the disclosure, which fall within the true spirit, and scope of the disclosure.", "Further, since numerous modifications and variations will readily occur to those skilled in the art, it is not desired to limit the disclosure to the exact construction and operation illustrated and described, and, accordingly, all suitable modifications and equivalents may be resorted to that fall within the scope of the disclosure." ] ]
Patent_15874410
[ [ "Apparatus, Method, and System for Diagnosing Reductant Deposits in an Exhaust Aftertreatment System", "An exhaust gas treatment system for an internal combustion engine may have a reductant delivery system that delivers reductant to an exhaust stream in an exhaust aftertreatment system.", "A temperature sensor may be positioned in or near the flow of reductant and exhaust to measure the temperature of the reductant and exhaust.", "A change in temperature over time, such as an increase, decrease, or change in variation amplitude, may indicate the presence of a reductant deposit in the system.", "Detection of the deposit may initiate a regeneration cycle in which the operating characteristics of the system change to eliminate the reductant deposit to prevent it from hindering the performance of the exhaust aftertreatment system." ], [ "1.A method for diagnosing existence of a reductant deposit in an exhaust aftertreatment system that delivers reductant to exhaust gas produced by an internal combustion engine to provide a mixture of exhaust gas and reductant, the method comprising: sampling a temperature of the mixture of exhaust gas and reductant with a temperature sensor positioned in or near the exhaust aftertreatment system; determining when the temperature is below a predetermined temperature value; in response to the determined temperature being below the predetermined threshold value, determining a presence of a reductant deposit in the exhaust aftertreatment system; and in response to determining the presence of the reductant deposit, initiating a regeneration cycle of the internal combustion engine to increase a temperature of the exhaust gas flowing through the exhaust aftertreatment system to at least partially remove the reductant deposit.", "2.The method of claim 1, further comprising, before sampling the temperature of the mixture of exhaust gas and reductant, positioning the temperature sensor in or near the exhaust aftertreatment system.", "3.The method of claim 1, wherein the predetermined temperature value is a value corresponding to a temperature indicative of impeded heat transfer due to the reductant deposit.", "4.The method of claim 1, wherein the temperature sensor is positioned near a boss that extends from a decomposition chamber of the exhaust aftertreatment system, and a reductant delivery system of the exhaust aftertreatment system delivers reductant to the exhaust gas through the boss.", "5.The method of claim 1, wherein the predetermined temperature value is less than a value for a normal temperature region.", "6.The method of claim 1, wherein sampling the temperature occurs at a predetermined time increment.", "7.The method of claim 1, wherein the temperature sensor is positioned outside of an exhaust line of the exhaust aftertreatment system.", "8.The method of claim 1, wherein the predetermined temperature value is between 100 degrees Celsius and 200 degrees Celsius.", "9.An on-board diagnostic apparatus for diagnosing an existence of a reductant deposit in an exhaust aftertreatment system, the apparatus comprising: a sampling circuit configured to sample a temperature of a mixture of exhaust gas and reductant with a temperature sensor; a comparison circuit configured to: determine when the temperature is below a predetermined temperature value; and in response to determining that the temperature is below the predetermined temperature value, determine a presence of a reductant deposit in an exhaust aftertreatment system; and a regeneration circuit configured to, in response to determining the presence of a reductant deposit, initiate a regeneration cycle of an internal combustion engine to increase a temperature of exhaust gas flowing through the exhaust aftertreatment system to at least partially remove the reductant deposit.", "10.The apparatus of claim 9, wherein the predetermined temperature value is a value corresponding to a temperature indicative of impeded heat transfer due to the reductant deposit.", "11.The apparatus of claim 9, wherein the temperature sensor is positioned near a boss that extends from a decomposition chamber of the exhaust aftertreatment system, and a reductant delivery system of the exhaust aftertreatment system delivers reductant to the exhaust gas through the boss.", "12.The apparatus of claim 9, wherein the predetermined temperature value is less than a value for a normal temperature region.", "13.The apparatus of claim 9, wherein sampling the temperature occurs at a predetermined time increment.", "14.The apparatus of claim 9, wherein the temperature sensor is positioned outside of an exhaust line of the exhaust aftertreatment system 15.The apparatus of claim 9, wherein the predetermined temperature value is between 100 degrees Celsius and 200 degrees Celsius.", "16.A system comprising: an exhaust aftertreatment system in fluid communication with the internal combustion engine to receive exhaust gas from the internal combustion engine, the exhaust aftertreatment system injecting reductant into the exhaust gas to create a mixture of exhaust gas and reductant, a temperature sensor positioned in or near the exhaust aftertreatment system; and an onboard diagnostic system including: a sampling circuit configured to sample a temperature of a mixture of exhaust gas and reductant with the temperature sensor; a comparison circuit configured to: determine when the temperature exceeds a predetermined temperature value; and in response to determining that the temperature exceeds the predetermined temperature value, determine a presence of a reductant deposit in an exhaust aftertreatment system; and a regeneration circuit configured to, in response to determining the presence of a reductant deposit, initiate a regeneration cycle to increase a temperature of exhaust gas flowing through the exhaust aftertreatment system to at least partially remove the reductant deposit.", "17.The system of claim 16, wherein the predetermined temperature value is a value corresponding to a temperature indicative of impeded heat transfer due to the reductant deposit.", "18.The system of claim 16, wherein the temperature sensor is positioned near a boss that extends from a decomposition chamber of the exhaust aftertreatment system, and a reductant delivery system of the exhaust aftertreatment system is configured to deliver reductant to the exhaust gas through the boss.", "19.The system of claim 16, wherein sampling the temperature occurs at a predetermined time increment.", "20.The system of claim 16, wherein the predetermined temperature value is less than a value for a normal temperature region." ], [ "<SOH> BACKGROUND <EOH>Emissions regulations for internal combustion engines have become more stringent over recent years.", "Environmental concerns have motivated the implementation of stricter emission requirements for internal combustion engines throughout much of the world.", "Governmental agencies, such as the Environmental Protection Agency (EPA) in the United States, carefully monitor the emission quality of engines and set acceptable emission standards, to which all engines must comply.", "Consequently, the use of exhaust aftertreatment systems on engines to reduce emissions is increasing.", "Generally, emission requirements vary according to engine type.", "Emission tests for compression-ignition (e.g., diesel) engines typically monitor the release of carbon monoxide (CO), unburned hydrocarbons (UHC), diesel particulate matter (PM) such as ash and soot, and nitrogen oxides (NO x ).", "With regard to reducing NO x emissions, NO x reduction catalysts, including selective catalytic reduction (SCR) systems, are utilized to convert NO x (NO and NO 2 in some fraction) to N 2 and other compounds.", "SCR systems utilize a reductant, typically ammonia, to reduce the NO x .", "Currently available SCR systems can produce high NO x conversion rates allowing the combustion technologies to focus on power and efficiency.", "However, currently available SCR systems also suffer from a few drawbacks.", "SCR systems utilize a reductant delivery system to introduce a reductant, such as aqueous urea or diesel exhaust fluid, into the exhaust stream upstream of the SCR catalyst.", "The reductant may tend to form deposits over time within the exhaust aftertreatment system, such as on exhaust aftertreatment components (e.g., reductant dosers) and/or on the walls of exhaust conduits (e.g., reductant decomposition chambers).", "Such deposits can adversely affect the operation of the engine (e.g., by restricting the exhaust flow passageway) and the exhaust aftertreatment system (e.g., by impeding the catalytic reaction).", "If the deposit is not soon detected and remedied, the engine system may not function properly.", "For example, reductant deposits may negatively affect fuel consumption, NO x reduction efficiency, and other operating characteristics of an internal combustion engine." ], [ "<SOH> SUMMARY <EOH>The subject matter of the present application has been developed in response to the present state of the art, and in particular, in response to the problems and needs in the art that have not yet been fully solved by currently available exhaust aftertreatment systems.", "Accordingly, the subject matter of the present application has been developed to provide apparatus, methods, and systems for diagnosing reductant deposit buildup that overcome at least some shortcomings of the prior art exhaust aftertreatment systems.", "According to one embodiment, an apparatus for diagnosing existence of reductant deposits in an exhaust aftertreatment system may have a reductant delivery system that delivers reductant to exhaust gas produced by an internal combustion engine to provide a mixture of exhaust gas and reductant, and a control module that operates the reductant delivery system.", "The apparatus may further have a sampling module that samples a first temperature of the mixture of exhaust gas and reductant and samples a second temperature of the mixture of exhaust gas and reductant, a calculation module that calculates a temperature differential between the first and second temperatures, and a comparison module that compares the first pressure differential with a threshold temperature differential to determine whether a reductant deposit exists within the exhaust aftertreatment system.", "Such an apparatus may further have a reporting module that reports a performance status indicating existence of a reductant deposit within the exhaust aftertreatment system.", "Such an apparatus may further have a regeneration module that receives the performance status and, in response to receipt of the performance status, initiates a regeneration cycle of the exhaust aftertreatment system to at least partially remove the reductant deposit.", "In such an apparatus, the sampling module may obtain the first and second temperatures from a temperature sensor positioned in a boss that extends from a decomposition chamber of the exhaust aftertreatment system, wherein the reductant delivery system delivers the reductant to the exhaust gas through the boss.", "In such an apparatus, the sampling module may obtain the first and second temperatures from a temperature sensor positioned in or near the exhaust aftertreatment system.", "After sampling the first temperature, the sampling module may wait for a time increment sufficient for the reductant deposit to form or increase significantly in size after sampling the first temperature.", "In such an apparatus, the threshold temperature differential may be a temperature rise from the first temperature to the second temperature.", "The comparison module may determine that the reductant deposit exists if the second temperature exceeds the first temperature by an amount greater than the temperature rise.", "In such an apparatus, the threshold temperature differential may be a temperature drop from the first temperature to the second temperature.", "The comparison module may determine that the reductant deposit exists if the first temperature exceeds the second temperature by an amount greater than the temperature drop.", "In such an apparatus, the threshold temperature differential may be a magnitude of temperature variation.", "The comparison module may determine that the reductant deposit exists if the absolute value of the difference between the first and second temperatures is greater than the magnitude of temperature variation.", "In such an apparatus the sampling module may further takes a plurality of temperature samples to obtain at least one of the first and second temperatures.", "At least one of the first and second temperatures may be an average temperature of the plurality of temperature samples.", "According to one method for diagnosing existence of a reductant deposit in an exhaust aftertreatment system, the exhaust aftertreatment system may deliver reductant to exhaust gas produced by an internal combustion engine to provide a mixture of exhaust gas and reductant.", "The method may include positioning a temperature sensor in or near the exhaust aftertreatment system, sampling a first temperature of the mixture of exhaust gas and reductant with the temperature sensor, and using the first temperature to make a comparison to determine whether a reductant deposit has formed in the exhaust aftertreatment system.", "Such a method may further include reporting a performance status that the reductant deposit exists within the exhaust aftertreatment system, and initiating a regeneration cycle of the internal combustion engine to at least partially remove the reductant deposit in response to receipt of the performance status.", "Such a method may further include waiting for a time increment sufficient for the reductant deposit to form or increase significantly in size after sampling the first temperature, sampling a second temperature of the mixture of exhaust gas and reductant with the temperature sensor after waiting for the time increment, and calculating a temperature differential between the first and second temperatures.", "In such a method, the temperature sensor may be positioned in a boss that extends from a decomposition chamber of the exhaust aftertreatment system.", "Delivering reductant to the exhaust gas may include delivering the reductant through the boss.", "In such a method, the threshold temperature differential may be a temperature rise from the first temperature to the second temperature.", "Comparing the temperature differential with the threshold temperature differential may include determining that the reductant deposit exists if the second temperature deposit exists by an amount greater than the temperature rise.", "In such a method, the threshold temperature differential may be a temperature drop occurring from the first temperature to the second temperature.", "Comparing the temperature differential with the threshold temperature differential may include determining that the reductant deposit exists if first temperature exceeds the second temperature by an amount greater than the temperature drop.", "In such a method, the threshold temperature may be a magnitude of temperature variation.", "Comparing the temperature differential with a threshold temperature differential may include determining that the reductant deposit exists if the absolute value of the difference between the first and second temperatures is greater than the magnitude of temperature variation.", "In such a method, at least one of sampling the first temperature and sampling the second temperature may include taking a plurality of temperature samples.", "At least one of the first temperature and the second temperature may be an average temperature of the plurality of temperature samples.", "An internal combustion engine system may have an internal combustion engine, an exhaust aftertreatment system in exhaust gas receiving communication with the internal combustion engine, a reductant delivery system in reductant supplying communication with exhaust gas in the exhaust aftertreatment system to provide a mixture of exhaust gas and reductant, a temperature sensor positioned to measure temperature of the mixture of exhaust gas and reductant, and an on-board diagnostic system that samples temperature data from the temperature sensor and uses the temperature data to determine whether a reductant deposit exists within the exhaust aftertreatment system.", "In such an internal combustion engine system, sampling temperature data from the temperature sensor may include obtaining a first temperature and a second temperature from the temperature sensor.", "The on-board diagnostic may further calculate a temperature differential between the first and second temperatures to provide a first temperature differential, and may compare the first temperature differential with a threshold temperature differential to determine whether a reductant deposit has formed in the exhaust aftertreatment system.", "In such an internal combustion engine system, the temperature sensor may be positioned in a boss that extends from a decomposition chamber of the exhaust aftertreatment system.", "The reductant delivery system may deliver the reductant to the exhaust gas through the boss.", "Reference throughout this specification to features, advantages, or similar language does not imply that all of the features and advantages that may be realized with the subject matter of the present disclosure should be or are in any single embodiment.", "Rather, language referring to the features and advantages is understood to mean that a specific feature, advantage, or characteristic described in connection with an embodiment is included in at least one embodiment of the present disclosure.", "Thus, discussion of the features and advantages, and similar language, throughout this specification may, but do not necessarily, refer to the same embodiment.", "The described features, structures, advantages, and/or characteristics of the subject matter of the present disclosure may be combined in any suitable manner in one or more embodiments and/or implementations.", "In the following description, numerous specific details are provided to impart a thorough understanding of embodiments of the subject matter of the present disclosure.", "One skilled in the relevant art will recognize that the subject matter of the present disclosure may be practiced without one or more of the specific features, details, components, materials, and/or methods of a particular embodiment or implementation.", "In other instances, additional features and advantages may be recognized in certain embodiments and/or implementations that may not be present in all embodiments or implementations.", "Further, in some instances, well-known structures, materials, or operations are not shown or described in detail to avoid obscuring aspects of the subject matter of the present disclosure.", "The features and advantages of the subject matter of the present disclosure will become more fully apparent from the following description and appended claims, or may be learned by the practice of the subject matter as set forth hereinafter." ], [ "CROSS-REFERENCE TO RELATED PATENT APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/981,265, filed Dec. 28, 2015, which is a continuation of U.S. patent application Ser.", "No.", "13/783,025, filed Mar.", "1, 2013, now U.S. Pat.", "No.", "9,261,006, issued Feb. 16, 2016.The contents of both applications are incorporated herein by reference in their entirety.", "FIELD This disclosure relates to internal combustion engines, and more particularly to diagnosing the operation of a reductant delivery system for treating exhaust gas in an exhaust gas aftertreatment system.", "BACKGROUND Emissions regulations for internal combustion engines have become more stringent over recent years.", "Environmental concerns have motivated the implementation of stricter emission requirements for internal combustion engines throughout much of the world.", "Governmental agencies, such as the Environmental Protection Agency (EPA) in the United States, carefully monitor the emission quality of engines and set acceptable emission standards, to which all engines must comply.", "Consequently, the use of exhaust aftertreatment systems on engines to reduce emissions is increasing.", "Generally, emission requirements vary according to engine type.", "Emission tests for compression-ignition (e.g., diesel) engines typically monitor the release of carbon monoxide (CO), unburned hydrocarbons (UHC), diesel particulate matter (PM) such as ash and soot, and nitrogen oxides (NOx).", "With regard to reducing NOx emissions, NOx reduction catalysts, including selective catalytic reduction (SCR) systems, are utilized to convert NOx (NO and NO2 in some fraction) to N2 and other compounds.", "SCR systems utilize a reductant, typically ammonia, to reduce the NOx.", "Currently available SCR systems can produce high NOx conversion rates allowing the combustion technologies to focus on power and efficiency.", "However, currently available SCR systems also suffer from a few drawbacks.", "SCR systems utilize a reductant delivery system to introduce a reductant, such as aqueous urea or diesel exhaust fluid, into the exhaust stream upstream of the SCR catalyst.", "The reductant may tend to form deposits over time within the exhaust aftertreatment system, such as on exhaust aftertreatment components (e.g., reductant dosers) and/or on the walls of exhaust conduits (e.g., reductant decomposition chambers).", "Such deposits can adversely affect the operation of the engine (e.g., by restricting the exhaust flow passageway) and the exhaust aftertreatment system (e.g., by impeding the catalytic reaction).", "If the deposit is not soon detected and remedied, the engine system may not function properly.", "For example, reductant deposits may negatively affect fuel consumption, NOx reduction efficiency, and other operating characteristics of an internal combustion engine.", "SUMMARY The subject matter of the present application has been developed in response to the present state of the art, and in particular, in response to the problems and needs in the art that have not yet been fully solved by currently available exhaust aftertreatment systems.", "Accordingly, the subject matter of the present application has been developed to provide apparatus, methods, and systems for diagnosing reductant deposit buildup that overcome at least some shortcomings of the prior art exhaust aftertreatment systems.", "According to one embodiment, an apparatus for diagnosing existence of reductant deposits in an exhaust aftertreatment system may have a reductant delivery system that delivers reductant to exhaust gas produced by an internal combustion engine to provide a mixture of exhaust gas and reductant, and a control module that operates the reductant delivery system.", "The apparatus may further have a sampling module that samples a first temperature of the mixture of exhaust gas and reductant and samples a second temperature of the mixture of exhaust gas and reductant, a calculation module that calculates a temperature differential between the first and second temperatures, and a comparison module that compares the first pressure differential with a threshold temperature differential to determine whether a reductant deposit exists within the exhaust aftertreatment system.", "Such an apparatus may further have a reporting module that reports a performance status indicating existence of a reductant deposit within the exhaust aftertreatment system.", "Such an apparatus may further have a regeneration module that receives the performance status and, in response to receipt of the performance status, initiates a regeneration cycle of the exhaust aftertreatment system to at least partially remove the reductant deposit.", "In such an apparatus, the sampling module may obtain the first and second temperatures from a temperature sensor positioned in a boss that extends from a decomposition chamber of the exhaust aftertreatment system, wherein the reductant delivery system delivers the reductant to the exhaust gas through the boss.", "In such an apparatus, the sampling module may obtain the first and second temperatures from a temperature sensor positioned in or near the exhaust aftertreatment system.", "After sampling the first temperature, the sampling module may wait for a time increment sufficient for the reductant deposit to form or increase significantly in size after sampling the first temperature.", "In such an apparatus, the threshold temperature differential may be a temperature rise from the first temperature to the second temperature.", "The comparison module may determine that the reductant deposit exists if the second temperature exceeds the first temperature by an amount greater than the temperature rise.", "In such an apparatus, the threshold temperature differential may be a temperature drop from the first temperature to the second temperature.", "The comparison module may determine that the reductant deposit exists if the first temperature exceeds the second temperature by an amount greater than the temperature drop.", "In such an apparatus, the threshold temperature differential may be a magnitude of temperature variation.", "The comparison module may determine that the reductant deposit exists if the absolute value of the difference between the first and second temperatures is greater than the magnitude of temperature variation.", "In such an apparatus the sampling module may further takes a plurality of temperature samples to obtain at least one of the first and second temperatures.", "At least one of the first and second temperatures may be an average temperature of the plurality of temperature samples.", "According to one method for diagnosing existence of a reductant deposit in an exhaust aftertreatment system, the exhaust aftertreatment system may deliver reductant to exhaust gas produced by an internal combustion engine to provide a mixture of exhaust gas and reductant.", "The method may include positioning a temperature sensor in or near the exhaust aftertreatment system, sampling a first temperature of the mixture of exhaust gas and reductant with the temperature sensor, and using the first temperature to make a comparison to determine whether a reductant deposit has formed in the exhaust aftertreatment system.", "Such a method may further include reporting a performance status that the reductant deposit exists within the exhaust aftertreatment system, and initiating a regeneration cycle of the internal combustion engine to at least partially remove the reductant deposit in response to receipt of the performance status.", "Such a method may further include waiting for a time increment sufficient for the reductant deposit to form or increase significantly in size after sampling the first temperature, sampling a second temperature of the mixture of exhaust gas and reductant with the temperature sensor after waiting for the time increment, and calculating a temperature differential between the first and second temperatures.", "In such a method, the temperature sensor may be positioned in a boss that extends from a decomposition chamber of the exhaust aftertreatment system.", "Delivering reductant to the exhaust gas may include delivering the reductant through the boss.", "In such a method, the threshold temperature differential may be a temperature rise from the first temperature to the second temperature.", "Comparing the temperature differential with the threshold temperature differential may include determining that the reductant deposit exists if the second temperature deposit exists by an amount greater than the temperature rise.", "In such a method, the threshold temperature differential may be a temperature drop occurring from the first temperature to the second temperature.", "Comparing the temperature differential with the threshold temperature differential may include determining that the reductant deposit exists if first temperature exceeds the second temperature by an amount greater than the temperature drop.", "In such a method, the threshold temperature may be a magnitude of temperature variation.", "Comparing the temperature differential with a threshold temperature differential may include determining that the reductant deposit exists if the absolute value of the difference between the first and second temperatures is greater than the magnitude of temperature variation.", "In such a method, at least one of sampling the first temperature and sampling the second temperature may include taking a plurality of temperature samples.", "At least one of the first temperature and the second temperature may be an average temperature of the plurality of temperature samples.", "An internal combustion engine system may have an internal combustion engine, an exhaust aftertreatment system in exhaust gas receiving communication with the internal combustion engine, a reductant delivery system in reductant supplying communication with exhaust gas in the exhaust aftertreatment system to provide a mixture of exhaust gas and reductant, a temperature sensor positioned to measure temperature of the mixture of exhaust gas and reductant, and an on-board diagnostic system that samples temperature data from the temperature sensor and uses the temperature data to determine whether a reductant deposit exists within the exhaust aftertreatment system.", "In such an internal combustion engine system, sampling temperature data from the temperature sensor may include obtaining a first temperature and a second temperature from the temperature sensor.", "The on-board diagnostic may further calculate a temperature differential between the first and second temperatures to provide a first temperature differential, and may compare the first temperature differential with a threshold temperature differential to determine whether a reductant deposit has formed in the exhaust aftertreatment system.", "In such an internal combustion engine system, the temperature sensor may be positioned in a boss that extends from a decomposition chamber of the exhaust aftertreatment system.", "The reductant delivery system may deliver the reductant to the exhaust gas through the boss.", "Reference throughout this specification to features, advantages, or similar language does not imply that all of the features and advantages that may be realized with the subject matter of the present disclosure should be or are in any single embodiment.", "Rather, language referring to the features and advantages is understood to mean that a specific feature, advantage, or characteristic described in connection with an embodiment is included in at least one embodiment of the present disclosure.", "Thus, discussion of the features and advantages, and similar language, throughout this specification may, but do not necessarily, refer to the same embodiment.", "The described features, structures, advantages, and/or characteristics of the subject matter of the present disclosure may be combined in any suitable manner in one or more embodiments and/or implementations.", "In the following description, numerous specific details are provided to impart a thorough understanding of embodiments of the subject matter of the present disclosure.", "One skilled in the relevant art will recognize that the subject matter of the present disclosure may be practiced without one or more of the specific features, details, components, materials, and/or methods of a particular embodiment or implementation.", "In other instances, additional features and advantages may be recognized in certain embodiments and/or implementations that may not be present in all embodiments or implementations.", "Further, in some instances, well-known structures, materials, or operations are not shown or described in detail to avoid obscuring aspects of the subject matter of the present disclosure.", "The features and advantages of the subject matter of the present disclosure will become more fully apparent from the following description and appended claims, or may be learned by the practice of the subject matter as set forth hereinafter.", "BRIEF DESCRIPTION OF THE DRAWINGS In order that the advantages of the subject matter may be more readily understood, a more particular description of the subject matter briefly described above will be rendered by reference to specific embodiments that are illustrated in the appended drawings.", "Understanding that these drawings depict only typical embodiments of the subject matter and are not therefore to be considered to be limiting of its scope, the subject matter will be described and explained with additional specificity and detail through the use of the drawings, in which: FIG.", "1 is a schematic diagram of an internal combustion engine system having an internal combustion engine and a reductant delivery system in accordance with one representative embodiment; FIG.", "2 is a schematic block diagram of the on-board diagnostic system and controller of the internal combustion engine system of FIG.", "1 according to one embodiment; FIG.", "3 is a cross-sectional side elevation view of a reductant doser boss and reaction chamber of an exhaust aftertreatment system according to one embodiment; FIG.", "4 is a chart illustrating how temperature data may change over time as a reductant deposit builds in an exhaust aftertreatment system according to one embodiment; and FIG.", "5 is a flow chart diagram illustrating a method for diagnosing and/or responding to the existence of a reductant deposit in an exhaust aftertreatment system according to one embodiment.", "DETAILED DESCRIPTION FIG.", "1 depicts one embodiment of an internal combustion engine system 10.The main components of the system 10 include an internal combustion engine 20 and an exhaust gas aftertreatment system, which may include a selective catalytic reduction (SCR) system 18.The SCR system 18 includes a reaction chamber 22 in which the catalytic process may occur.", "The reaction chamber 22 may be in exhaust gas receiving communication with the internal combustion engine 20 via an exhaust line 24.The reaction chamber 22 can include any of various catalysts, such as an SCR catalyst, configured to reduce nitrogen-oxides in the presence of ammonia, which can be obtained from the reduction of a reductant, such as aqueous urea.", "The internal combustion engine 20 can be a compression-ignited internal combustion engine, such as a diesel fueled engine, or a spark-ignited internal combustion engine, such as a gasoline fueled engine operated lean.", "Combustion of the fuel and air in the compression chambers of the internal combustion engine 20 produces exhaust gas that is operatively vented to the exhaust line 24.From the exhaust line 24, at least a portion of the exhaust gas stream flows from into and through the exhaust gas aftertreatment system and SCR system 18 prior to being vented into the atmosphere through a tailpipe 26.A temperature sensor 28 may be positioned in or near the exhaust line 24.Generally, the SCR system 18 may be configured to remove various chemical compounds and particulate emissions present in the exhaust gas received from the exhaust line 24.In addition to the reaction chamber 22, the SCR system 18 may include a reductant delivery system 30.Additionally or alternatively, the SCR system 18 may include any of various other exhaust treatment components known in the art, such as an oxidation catalyst, a particulate matter filter, and an ammonia oxidation catalyst.", "The reductant delivery system 30 may include a reductant source, which may take the form of a reductant tank, a reductant pump, and a doser, which operates as a reductant delivery mechanism and may take the form of an injector 36 that injects reductant 38 into the exhaust gas stream.", "The reductant may be any substance known in the art that facilitates the breakdown, combination, and/or other conversion to inert form of pollutants in an exhaust gas stream.", "Thus, the reductant may include aqueous ammonia (NH3), aqueous urea, diesel fuel, diesel exhaust fluid, and/or diesel oil.", "The injector 36 may be selectively controllable via actuation of a control valve to inject a desired amount of reductant 38 into the exhaust gas stream.", "The injector 36 may be positioned to inject reductant 38 into the exhaust line 24 upstream of the reaction chamber 22 and/or directly into the reaction chamber itself.", "As will be shown in FIG.", "3, the temperature sensor 28 may be positioned proximate the injection site at which the reductant 38 enters the exhaust stream.", "The internal combustion engine system 10 may also include an on-board diagnostic system (OBD) system 40 that receives information related to the operation of the system 10.The OBD system 40 may communicate with a controller 42 that controls operation of the system 10 and associated sub-systems, such as the internal combustion engine 20 and the reductant delivery system 30.The OBD system 40 and the controller 42 are each depicted in FIG.", "1 as a single physical unit, but each may include two or more physically separated units or components in some embodiments if desired.", "Alternatively, the OBD system 40 and the controller 42 may be combined into a single unit that performs both diagnostic and control functions.", "Generally, the OBD system 40 and the controller 42 may each receive multiple inputs, process the inputs, and transmit multiple outputs.", "In FIG.", "1, only a few inputs and outputs are shown.", "More specifically, the OBD system 40 may receive temperature data 50 from the temperature sensor 28, and may use the temperature data 50 to determine a performance status 52 of the system 10.More specifically, the temperature data 50 may be used to determine whether there is a reductant deposit residing in the exhaust line 24 and/or the reaction chamber 22.The performance status 52 shown in FIG.", "1 may be indicative of whether such a deposit is present.", "The performance status 52 may include a number indicative of the size or severity of the deposit, or may simply include a “yes” or “no” indicator indicating whether the deposit has reached a threshold size or severity.", "The OBD system 40 may issue other performance status data (not shown), which may include data regarding other operating characteristics of the system 10.The controller 42 may receive the performance status 52 and/or other data and/based on the performance status 52 and other data, issue a command 54 to the internal combustion engine 20 and/or issue a command 56 to the reductant delivery system 30.The commands 54, 56 may direct the internal combustion engine 20 and/or the reductant delivery system 30 to take certain steps to optimize the operation of the system 10 (e.g., perform a regeneration of the exhaust aftertreatment system), shut down the system if a safety concern is present, or the like.", "If desired, the OBD system 40 and/or the controller 42 may be designed to provide the performance status 52 and/or other data to a user, such as a driver of the vehicle containing the system 10.The performance status 52 may be provided, for example, via a light or LED, an auditory signal or alarm, an analog gauge, a digital readout, or the like.", "Moreover, the user may manually select and enter the command 54 and/or the command 56 based on the performance status 42 indicated to the user.", "Alternatively, the OBD system 40 and/or the controller 42 may operate substantially transparently to the user so that the commands are issued automatically.", "Referring to FIG.", "2, the OBD system 40 and the controller 42 may include various modules for diagnosing and controlling the operation of the system 10.As shown in FIG.", "2, the OBD system 40 may include a sampling module 58, a calculation module 60, a comparison module 62, and a reporting module 64.The controller 42 may include a control module 66 and a regeneration module 68.While not specifically illustrated and described with reference to FIG.", "2, the OBD system 40 and/or the controller 42 may include additional controller modules for conducting other control system functions.", "The OBD system 40, the controller 42 and/or their various modular components may comprise processor, memory, and interface modules that may be fabricated of semiconductor gates on one or more semiconductor substrates.", "Each semiconductor substrate may be packaged in one or more semiconductor devices mounted on circuit cards.", "Connections between the modules may be through semiconductor metal layers, substrate-to-substrate wiring, or circuit card traces or wires connecting the semiconductor devices.", "During normal operation of the reductant delivery system 30, the OBD system 40, or more specifically, the sampling module 58, may receive temperature data 50 from the temperature sensor 28.The sampling module 58 may receive other sensor data (not shown) from other sensors that provide data regarding the operation of the SCR system 18 such as, for example, pressure sensor data from the reductant delivery system 30, the exhaust line 24, and/or the reaction chamber 22, temperature data from other temperature sensors, flow meter data indicating the rate of flow of the reductant 38 into the exhaust stream, and/or data from other sensors as known in the art.", "However, one benefit of the present disclosure is that these sensors may not be required to properly diagnose whether a reductant deposit exists in the SCR system 18.The calculation module 60 may use the temperature data 50 and/or other sensor data to calculate metrics useful in diagnosing the operation of the SCR system 18, such as temperature differentials occurring over time as the SCR system 18 operates.", "The comparison module 62 may compare the metrics provided by the calculation module 60 with other data, such as metrics obtained from previous operation of the SCR system 18, established thresholds, or the like.", "The reporting module 64 may, based on the output of the comparison module 62, provide the performance status 52 of the SCR system 18 to, for example, the controller 42.If desired, the performance status 52 may include a variety of data such as flow rates, pressures, temperatures, and other data reflecting the operating conditions of the SCR system 18.In certain implementations, the OBD system 40 may accumulate or sum a plurality of errors, or deficiencies, related to exhaust temperature and/or other aspects of the operation of the SCR system 18 tracked by the OBD system 40, and compare the accumulated error data with at least one predetermined threshold.", "The predetermined threshold can be a regulated threshold or some other threshold associated with a system having an undesirable or unlawful amount of blockage.", "If the accumulated error data meets the threshold, then the reporting module 64 may issue a performance status 52 indicating failure of the SCR system 18 to meet operational or regulatory standards.", "However, if the accumulated error data does not meet the threshold, then the reporting module 64 may issues a performance status 52 indicating that the SCR system 18 “passes,” e.g., the SCR system 18 meets and/or is likely to continue meeting applicable standards.", "Alternatively, the performance status 52 may provide some other indication (e.g., “poor”) of the performance of the SCR system 18 based on whether the accumulated error data meets the threshold.", "The comparison module 62 may compare the accumulated error data against multiple thresholds to provide a performance status 52 that indicates one of varying degrees of performance (e.g., “poor,” “medium-poor,” “medium,” “medium-good,” and “good”).", "In this manner, the OBD system 40 may report to a user the evolution (e.g., rate of decay) of the performance of the SCR system 18 over time such that a user can anticipate when the SCR system 18 may fail to meet the applicable standards.", "In addition to, or in the alternative to, reporting the performance status 52 to the user, the reporting module 64 may provide the performance status 52 to the controller 42 so that the controller 42 can utilize the performance status 52 to automatically adjust the operation of the system 10.For example, the control module 66 may use the performance status 52 to issue the command 56 to the reductant delivery system 30 to speed up, slow down, or stop the flow of the reductant 38 into the exhaust line 24.The regeneration module 68 may use the performance status 52 to issue the command 54 to the internal combustion engine 20 to modify the operation of the internal combustion engine 20, for example, by initiating a regeneration cycle in which the internal combustion engine 20 produces exhaust at higher-than-average temperatures to burn away or otherwise remove reductant deposits within the exhaust line 24 and/or the reaction chamber 22.Referring to FIG.", "3, a side elevation, section view illustrates the juncture of the exhaust line 24 with the reaction chamber 22, which may also be the part of the exhaust line 24 that receives the reductant 38 from the reductant delivery system 30.As shown, the exhaust line 24 may have an exterior wall 69 defining a generally tubular shape.", "The reaction chamber 22 may simply be a region of the generally tubular shape defined by the exterior wall 69 immediately downstream of the entry point of the reductant 38, in which reductant 38 is combined with exhaust 39 to define a mixture in which the catalytic reduction can occur.", "As shown, the exhaust line 24 may have a boss 70 that extends at an angle from the exterior wall 69 of the exhaust line 24.The boss 70 may have an aperture 72 through which the reductant 38 is injected by the injector 36.Thus, the reductant 38 may spray into the exhaust stream as shown (e.g., from left to right in FIG.", "3).", "The regions immediately downstream of the aperture 72 may receive reductant 38 that has not fully mixed with the exhaust stream yet, and may thus be particularly susceptible to the buildup of reductant deposits.", "By way of example, a reductant deposit 74 is illustrated in FIG.", "3.Such deposits need not be located as shown, but may be anywhere in the exhaust line 24, the reaction chamber 22, and/or the tailpipe 26 at or downstream of the entry point of the reductant 38.Additionally, the shape of the reductant deposit 74 is merely exemplary.", "Reductant deposits may take a variety of shapes, including stalactite shapes, conical shapes, asymmetrical lumps, etc.", "Such reductant deposits may develop on the interior wall of the exterior wall 69 or on any structure within the interior of the exhaust line 24, the reaction chamber 22, and/or the tailpipe 26, such as any filter positioned in any of these locations.", "FIG.", "3 also illustrates one example of placement of the temperature sensor 28.As shown, the temperature sensor 28 is within the trailing end of the boss 70, proximate the location where the trailing end of the boss 70 joins the exhaust line 24.It has been discovered that the formation of a reductant deposit like the reductant deposit 74 may cause a reduction in the temperature of the mixture of exhaust and reductant 38.This may be for a variety of reasons, including the fact that the reductant 38 is an insulator, and the flow patterns of exhaust and reductant 38 are altered by the physical presence of the reductant deposit 74.Positioning the temperature sensor 28 at the location shown in FIG.", "3 may provide the benefit of exposing the temperature sensor 28 to a relatively large temperature variation that occurs with development of the reductant deposit 74.Specifically, during normal operation of the SCR system 18, eddy currents in the mixture of exhaust gas and reductant 38 may develop within the boss 70.Such eddy currents may contain heated gases moving at a relatively high velocity that therefore transmit considerable heat to any structures within the exhaust line 24 and/or the exhaust line 24, and to the exterior wall 69.The presence of a reductant deposit such as the reductant deposit 74 may impede the flow of these eddy currents, thereby impeding the associated heat transfer to reduce the temperature of structures within the exhaust line 24 and/or the exhaust line 24, and of the exterior wall 69.Thus, the location of the temperature sensor 28 shown in FIG.", "3 may be beneficial because the temperature sensor 28 may be positioned within or near where these eddy currents normally develop.", "The temperature sensor 28 may, in its entirety, be positioned in the boss 70 as shown.", "Alternatively, the temperature sensor 28 may be inserted through a small opening (not shown) in the exterior wall 69 or the wall of the boss 70 so that the sensing portion of the temperature sensor 28 is positioned within the boss 70.The temperature sensor 28 may be any type of temperature sensor known in the art, including thermocouples, resistance temperature detectors (RTDs), thermistors, and the like.", "The temperature sensor 28 may alternatively be positioned at a wide variety of locations, either within the boss 70, within the reaction chamber 22, or within the exhaust line 24 proximate or downstream of the boss 70.As another alternative, the temperature sensor 28 may be positioned outside the exhaust line 24, the reaction chamber 22, and/or the boss 70.At such a location, the temperature sensor 28 may effectively measure heat transfer through the exterior wall 69 and/or the wall of the boss 70.The speed at which heated gas flows through the exhaust line 24, the reaction chamber 22, and/or the boss 70 may control heat transfer through these structures, so positioning the temperature sensor 28 outside the flow of gas may provide sufficient data to determine whether a reductant deposit has formed.", "Referring to FIG.", "4, a chart 80 illustrates how temperature data may change over time as a reductant deposit builds in the exhaust aftertreatment system such as the SCR system 18 of FIG.", "1.The chart 80 has a horizontal axis 82 that indicates elapsed time, and a vertical axis 84 that indicates the temperature measured by a temperature sensor such as the temperature sensor 28.A temperature line 86 shows how the temperature may vary over time.", "As shown, the temperature line 86 may have multiple regions including a normal temperature region 88, an increased temperature region 89, a decreased temperature region 90, and a low temperature region 91.The normal temperature region 88 may represent the performance of the SCR system 18 under generally normal conditions, i.e., without a significant reductant deposit.", "As a reductant deposit like the reductant deposit 74 begins to form, it may cause a short-term increase in temperature as indicated by the increased temperature region 89.The brief increase in exhaust temperature may be caused by a temporary increase in the velocity of eddy currents within the boss 70 or other gas flow and/or heat transfer phenomena.", "As the reductant deposit grows, the temperature may drop for the reasons set forth in the discussion of FIG.", "3, thus leading to the reduced temperature region 90 immediately after the temperature drop, and subsequently, the low temperature region 91 in which the temperature remains relatively low (with significant variation) until the reductant deposit is removed.", "The variation is caused by the continual evolution of the formation of the deposit (e.g., brief periods of incremental build-up between brief periods of incremental reduction).", "The normal temperature region 88 may have a relatively stable temperature.", "This temperature may be on the order of 225° C. to 325° C. in some embodiments.", "The normal temperature region 88 may have a variation 94 between its maximum and minimum temperatures that is relatively low, for example, only a few degrees Centigrade.", "The temperature may then rise by a temperature increase 95 from the average temperature in the normal temperature region 88 to reach the maximum temperature of the increased temperature region 89.Alternatively, the temperature may fall as it approaches the increased temperature region 89 so that the maximum temperature of the increased temperature region 89 is no higher than the average temperature in the normal temperature region 88.However, in this case, a discernible temperature increase may still exist during the early stages of deposit formation.", "The temperature increase may define an increased temperature region with a sharper increase than the increased temperature region 89 of FIG.", "4 so as to define a temperature “spike.” After the increased temperature region 89, the temperature may fall back to the average temperature in the normal temperature region 88, and continue to fall by a temperature decrease 96 from the average temperature in the normal temperature region 88 to the average temperature in the low temperature region 91.The average temperature in the low temperature region 91 may be on the order of 100° C. to 200° C. in some embodiments.", "The low temperature region 91 may exhibit a variation 97 in temperature that is relatively large, for example, around 50° C. or even 100° C. The chart 80 provides a number of different characteristics of the temperature that can be compared with established thresholds to diagnose the formation of a reductant deposit within the SCR system 18.Additionally, the OBD system 40 need not sample a continuous stream of temperature data; rather, sampling two temperature data points may be sufficient.", "For example, the OBD system 40 may simply compare a first temperature sampled from within the normal temperature region 88 with a second temperature sampled from within the low temperature region 91.If the temperature differential (i.e., the temperature drop) between the first and second temperatures exceeds a threshold temperature differential, the OBD system 40 may determine that a reductant deposit exists within the SCR system 18.This method will be shown and described in connection with FIG.", "5.Referring to FIG.", "5, a flow chart diagram illustrates a method 100 for diagnosing and/or responding to the existence of a reductant deposit in the SCR system 18 of FIG.", "1, according to one embodiment of the invention.", "The method 100 may operate continuously, or may be triggered by one or more events such as the passage of a certain time increment since the last time the method 100 was carried out, the previous detection of a reductant deposit, the previous initiation of a regeneration cycle, the presence of certain loading or operating conditions of the internal combustion engine 20, or other conditions involved in the operation of the system 10.As shown, the method may start 110 with a step 120 in which the internal combustion engine 20 is operated to begin producing exhaust.", "In a step 130, the reductant 38 may be delivered to the exhaust stream.", "In a step 140, the sampling module 58 may be used to sample a first temperature of the mixture of exhaust and reductant from the temperature sensor 28.The first temperature may be sampled during the normal temperature region 88 of the temperature line 86.In a step 150, the OBD system 40 may wait for a given time increment such as, for example, the time required for the temperature to progress from the normal temperature region 88 of FIG.", "4 to the decreased temperature region 90 or the low temperature region 91 of FIG.", "4 if a reductant deposit is forming.", "However, if the temperature sampling is continuous, the step 150 may be omitted.", "Once the desired time increment has passed, the sampling module 58 may sample a second temperature of the mixture of exhaust and reductant from the temperature sensor 28.The second temperature may be sampled during the low temperature region 91 of the temperature line 86.Then, in a step 170, the calculation module 60 may calculate the temperature differential between the first and second temperatures sampled in the step 140 and the step 160.This may be accomplished by subtracting the first temperature from the second temperature.", "Then, in a step 180, the comparison module 62 may compare the temperature differential with a threshold temperature differential.", "In a query 190, if the temperature differential does not exceed the threshold temperature differential, the method 100 may progress to a step 192 in which the reporting module 64 generates the performance status 52 indicating that there is no significant reductant deposit.", "The method 100 may then restart, either immediately or after a desired time increment has passed.", "If the temperature differential does exceed the threshold temperature differential, the method 100 may progress to a step 194 in which the reporting module 64 generates the performance status 52 indicating that a significant reductant deposit does exist.", "If desired, in a step 196, a regeneration cycle may then be initiated to automatically regenerate the SCR system 18 to clear the reductant deposit.", "According to one example, regeneration may be accomplished by transmitting the performance status 52 to the controller 42 so that the controller 42 can automatically initiate the desired remedial measures.", "The control module 66 may issue the command 56 to the reductant delivery system 30 to alter the operation of the reductant delivery system 30 to facilitate removal of the reductant deposit, for example, by stopping the flow of the reductant 38 through the injector 36.The regeneration module 68 may similarly issue the command 54 to the internal combustion engine 20 to alter the operation of the internal combustion engine 20 to further help remove the reductant deposit.", "For example, the command 54 may cause the internal combustion engine 20 to run at a higher temperature, thereby increasing the temperature of the exhaust stream flowing through the exhaust line 24 to a temperature that breaks down, burns, and/or otherwise removes the reductant deposit.", "After the regeneration cycle has been completed, the method 100 may then restart, either immediately or after a desired time increment has passed.", "It may be desirable to restart the method 100 immediately after completion of the step 196 to ensure that the reductant deposit has been successfully removed.", "Alternatively, a modified method may be used after the performance of the step 196.For example, only a single temperature (e.g., a third temperature) may need to be sampled.", "The third temperature may be compared with the first temperature and/or the second temperature to rapidly determine whether the SCR system 18 has returned to normal operating conditions.", "In the alternative to the foregoing method, the OBD system 40 may use different methods to diagnose the existence of a reductant deposit.", "For example, the OBD system 40 may instead calculate the temperature differential between a first temperature within the normal temperature region 88 and a second temperature within the increased temperature region 89.The resulting temperature differential may then be a temperature rise.", "In other alternatives, the OBD system 40 may calculate the temperature differential between a first temperature within the normal temperature region 88 or within the increased temperature region 89 and a second temperature within the decreased temperature region 90.Again, the temperature differential may be a temperature drop.", "In any of the foregoing cases, the elapsed time between measurement of the first and second temperatures may be determined from observation of experimental data, i.e., how long the SCR system 18 takes, during formation of a reductant deposit, to go from the normal temperature region 88 to the increased temperature region 89, the decreased temperature region 90, or the low temperature region 91, or from the increased temperature region 89 to the decreased temperature region 90 or low temperature region 91, etc.", "A simple comparison of two temperature data points can be made as set forth above or, if desired, additional temperature data points may be collected and analyzed to provide a more complete and/or reliable diagnosis.", "In the alternative to looking for a temperature drop or a temperature rise, the OBD system 40 may instead look for a change in other characteristics of the temperature data.", "In one embodiment, the OBD system 40 analyzes the temperature data to look for the amplitude of variations in the temperature over time.", "For example, the OBD system 40 may sample temperature data and, based on a standard deviation or other measurement of variation of the data, determine whether a reductant deposit exists.", "If the variation in temperature data is like the variation 94 in FIG.", "4, the OBD system 40 may conclude that there is no significant reductant deposit in the SCR system 18.Conversely, if the variation in temperature data is like the variation 97 in FIG.", "4, the OBD system 40 may conclude that a reductant deposit exists in the SCR system 18.If the OBD system 40 is measuring temperature amplitude instead of a temperature drop or temperature rise, the calculation module 60 may determine an absolute value of the difference between the first and second temperatures.", "The comparison module 62 may then compare this absolute value to a threshold temperature differential that acts as a threshold amplitude.", "If the absolute value of the difference is greater than the threshold amplitude, the reporting module 64 may issue the performance status 52 indicating that there is a reductant deposit.", "If the absolute value of the difference is not greater than the threshold amplitude, the reporting module 64 may issue the performance status 52 indicating that there is no reductant deposit.", "As another alternative to the method 100 of FIG.", "5, a different OBD system (not shown) may only sample a single temperature from a single temperature sensor like the temperature sensor 28.If the single temperature is, for example, below a given temperature threshold, the OBD system may then determine that a reductant deposit has formed.", "For example, if the steady-state temperature of the exhaust aftertreatment system is 225° C. to 325° C., the OBD system may determine that the reductant deposit exists if the temperature reading is below 225° C. Other temperatures may, of course, be used for the threshold, such as 125° C., 150° C., 175° C., or 200° C. As yet another alternative, a different OBD system (not shown) may only sample a single temperature from a single temperature sensor like the temperature sensor 28.If the single temperature is, for example, above a given temperature threshold, the OBD system may then determine that a reductant deposit has formed.", "For example, if the steady-state temperature of the exhaust aftertreatment system is 225° C. to 325° C., the OBD system may determine that the reductant deposit exists if the temperature reading is greater than 325° C. Other temperatures may, of course, be used for the threshold, such as 350° C. or 375° C. Such a method makes use of the temperature “spike” that may be observed upon initial formation of the reductant deposit.", "The chart 80 is merely exemplary and represents how the data from one location of the temperature sensor 28 might appear.", "The manner in which the temperature responds to reductant deposit formation will be different for each temperature sensor location.", "Similarly, the manner in which the deposit formation is diagnosed by the OBD system 40 may be different from the methods set forth above.", "A wide variety of temperature phenomena may occur over time with different sensor placements; the present invention contemplates all methods utilizing any such phenomena to diagnose the existence of a reductant deposit in an exhaust aftertreatment system.", "If desired, multiple temperature sensors (not shown) may be used to provide multiple sources of temperature data for more accurate diagnosis.", "If multiple sensors are used, the comparison module 62 may be used to compare data from multiple sensors, in place of or in addition to the comparison of data from a single sensor taken at different points in time.", "For example, in addition to the temperature sensor 28, an additional temperature sensor may be placed upstream of the boss 70, and the temperature drop from the upstream sensor to the temperature sensor 28 may be calculated and compared with pre-existing thresholds to determine whether an obstruction such as the reductant deposit 74 is producing a larger-than-expected temperature drop.", "As another alternative, other types of sensors may be used in combination with the temperature sensor 28.For example, one or more pressure sensors may be positioned in the exhaust line 24, the reaction chamber 22, and/or the boss 70 to measure the pressure drop occurring within one or more of these components.", "Such information may help to determine whether the temperature data 50 truly indicates the presence of a reductant deposit, or are indicative of a different anomaly within the SCR system 18.For example, the temperature of the mixture of exhaust and reductant 38 may also be affected by the pressure of the mixture, which may in turn be affected by factors such as the dosing rate of the reductant 38 and the loading of the internal combustion engine 20.Thus, the comparison module 62 may reference not just one threshold temperature differential, but may have an array of threshold temperature differentials that apply to different operating conditions of the system 10 and/or to different pressures of the mixture of exhaust and reductant 38.According to one example, each range of pressure drops within the exhaust line 24 may have a different threshold temperature differential that applies to it.", "Thus, the sampling module 58 may sample pressure data (not shown) in addition to the temperature data 50.The calculation module 60 may calculate a pressure drop, or “pressure differential” in addition to the temperature differential.", "The comparison module 62 may then reference an array of pressure differential ranges to find the range within which the measured pressure differential falls, and then locate the applicable threshold temperature differential.", "This threshold temperature differential may then be used by the comparison module 62 to determine whether a reductant deposit is present within the SCR system 18.The schematic flow chart diagrams and method schematic diagrams described above are generally set forth as logical flow chart diagrams.", "As such, the depicted order and labeled steps are indicative of representative embodiments.", "Other steps, orderings and methods may be conceived that are equivalent in function, logic, or effect to one or more steps, or portions thereof, of the methods illustrated in the schematic diagrams.", "Additionally, the format and symbols employed are provided to explain the logical steps of the schematic diagrams and are understood not to limit the scope of the methods illustrated by the diagrams.", "Although various arrow types and line types may be employed in the schematic diagrams, they are understood not to limit the scope of the corresponding methods.", "Indeed, some arrows or other connectors may be used to indicate only the logical flow of a method.", "For instance, an arrow may indicate a waiting or monitoring period of unspecified duration between enumerated steps of a depicted method.", "Additionally, the order in which a particular method occurs may or may not strictly adhere to the order of the corresponding steps shown.", "Many of the functional units described in this specification have been labeled as modules, in order to more particularly emphasize their implementation independence.", "For example, a module may be implemented as a hardware circuit comprising custom VLSI circuits or gate arrays, off-the-shelf semiconductors such as logic chips, transistors, or other discrete components.", "A module may also be implemented in programmable hardware devices such as field programmable gate arrays, programmable array logic, programmable logic devices or the like.", "Modules may also be implemented in software for execution by various types of processors.", "An identified module of executable code may, for instance, comprise one or more physical or logical blocks of computer instructions, which may, for instance, be organized as an object, procedure, or function.", "Nevertheless, the executables of an identified module need not be physically located together, but may comprise disparate instructions stored in different locations which, when joined logically together, comprise the module and achieve the stated purpose for the module.", "Indeed, a module of computer readable program code may be a single instruction, or many instructions, and may even be distributed over several different code segments, among different programs, and across several memory devices.", "Similarly, operational data may be identified and illustrated herein within modules, and may be embodied in any suitable form and organized within any suitable type of data structure.", "The operational data may be collected as a single data set, or may be distributed over different locations including over different storage devices, and may exist, at least partially, merely as electronic signals on a system or network.", "Where a module or portions of a module are implemented in software, the computer readable program code may be stored and/or propagated on in one or more computer readable medium(s).", "The computer readable medium may be a tangible computer readable storage medium storing the computer readable program code.", "The computer readable storage medium may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, holographic, micromechanical, or semiconductor system, apparatus, or device, or any suitable combination of the foregoing.", "More specific examples of the computer readable medium may include but are not limited to a portable computer diskette, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or Flash memory), a portable compact disc read-only memory (CD-ROM), a digital versatile disc (DVD), an optical storage device, a magnetic storage device, a holographic storage medium, a micromechanical storage device, or any suitable combination of the foregoing.", "In the context of this document, a computer readable storage medium may be any tangible medium that can contain, and/or store computer readable program code for use by and/or in connection with an instruction execution system, apparatus, or device.", "The computer readable medium may also be a computer readable signal medium.", "A computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave.", "Such a propagated signal may take any of a variety of forms, including, but not limited to, electrical, electro-magnetic, magnetic, optical, or any suitable combination thereof.", "A computer readable signal medium may be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport computer readable program code for use by or in connection with an instruction execution system, apparatus, or device.", "Computer readable program code embodied on a computer readable signal medium may be transmitted using any appropriate medium, including but not limited to wireless, wireline, optical fiber cable, Radio Frequency (RF), or the like, or any suitable combination of the foregoing In one embodiment, the computer readable medium may comprise a combination of one or more computer readable storage mediums and one or more computer readable signal mediums.", "For example, computer readable program code may be both propagated as an electro-magnetic signal through a fiber optic cable for execution by a processor and stored on RAM storage device for execution by the processor.", "Computer readable program code for carrying out operations for aspects of the present invention may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, Smalltalk, C++ or the like and conventional procedural programming languages, such as the “C” programming language or similar programming languages.", "The computer readable program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server.", "In the latter scenario, the remote computer may be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet Service Provider).", "Reference throughout this specification to “one embodiment,” “an embodiment,” or similar language means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention.", "Thus, appearances of the phrases “in one embodiment,” “in an embodiment,” and similar language throughout this specification may, but do not necessarily, all refer to the same embodiment.", "Similarly, the use of the term “implementation” means an implementation having a particular feature, structure, or characteristic described in connection with one or more embodiments of the present disclosure, however, absent an express correlation to indicate otherwise, an implementation may be associated with one or more embodiments.", "The present disclosure may be embodied in other specific forms without departing from its spirit or essential characteristics.", "The described embodiments are to be considered in all respects only as illustrative and not restrictive.", "The scope of the disclosure is, therefore, indicated by the appended claims rather than by the foregoing description.", "All changes which come within the meaning and range of equivalency of the claims are to be embraced within their scope." ] ]
Patent_15874412
[ [ "WOOD FLOORING WITH REINFORCED THERMOPLASTIC UNDERLAYER", "An example reinforced wood flooring for use in forming a truck trailer or container floor may include a wood member.", "The wood member may include a plurality of wood strips that are attached together.", "The wood member may also have a top surface and a bottom surface.", "An essentially water impermeable fiber-reinforced thermoplastic underlay may be adhered to the bottom surface of the wood member." ], [ "1.A reinforced wood flooring for use in a vehicle, trailer, or container, the reinforced wood flooring comprising: a floor board having a bottom surface, a width, and a length; an underlay attached to the bottom surface of the floor board, the underlay includes a plurality of layers; wherein the plurality of layers includes a first layer comprising a first plurality of fibers disposed within a thermoplastic material; wherein the underlay has a first flexural strength substantially along a first direction of the floor board and a second flexural strength substantially along a second direction of the floor board; wherein the first flexural strength and the second flexural strength of the underlay are designed to strengthen the floor board while simultaneously having a flexibility that allows the underlay to flex with the floor board substantially without at least partially separating from the floor board.", "2.The reinforced wood flooring of claim 1, wherein the first plurality of fibers in the first layer include continuous fibers.", "3.The reinforced wood flooring of claim 1, wherein the first plurality of fibers in the first layer include discontinuous fibers.", "4.The reinforced wood flooring of claim 1, wherein the first plurality of fibers in the first layer include randomly distributed fibers.", "5.The reinforced wood flooring of claim 1, wherein the first plurality of fibers in the first layer are aligned with a longitudinal axis of the floor board.", "6.The reinforced wood flooring of claim 1, wherein the plurality of layers includes a second layer.", "7.The reinforced wood flooring of claim 6, wherein the second layer includes a thermoset material.", "8.The reinforced wood flooring of claim 6, wherein the second layer includes a second plurality of fibers and a thermoplastic material.", "9.The reinforced wood flooring of claim 8, wherein the second plurality of fibers are aligned with a longitudinal axis of the floor board.", "10.The reinforced wood flooring of claim 8, wherein the first plurality of fibers are oriented in a first direction and wherein the second plurality of fibers are oriented in a second direction that is substantially normal to the first direction.", "11.The reinforced wood flooring of claim 1, wherein the underlay is attached to the floor board with an adhesive.", "12.The reinforced wood flooring of claim 1, wherein the first plurality of fibers include inorganic fibers.", "13.The reinforced wood flooring of claim 1, wherein the first plurality of fibers includes organic fibers.", "14.A wood floor for use in a vehicle, trailer, or container, the wood floor comprising: a floor board: a bottom surface, a length, a width, a longitudinal axis, and an underlay designed to limit water migration, the underlay being configured to flex with the floor board without at least partially separating from the floor board; wherein a first layer of the underlay comprises a first plurality of fibers disposed within a thermoplastic resin, the first plurality of fibers being substantially aligned with the longitudinal axis; wherein a second layer of the underlay comprises a second plurality of fibers oriented substantially orthogonal to the longitudinal axis; wherein a third layer of the underlay comprise a third plurality of fibers substantially aligned with the longitudinal axis; and wherein the underlay has a first flexural load substantially along the length of the floor board and a second flexural load substantially along the width of the floor board.", "15.The wood floor of claim 14, wherein the second layer includes a thermoplastic material.", "16.The wood floor of claim 14, wherein the third layer includes a thermoplastic material.", "17.The wood floor of claim 14, wherein the second layer and the third layer include a thermoplastic material.", "18.The wood floor of claim 14, wherein the first plurality of fibers, the second plurality of fibers, the third plurality of fibers, or a combination thereof include fiberglass fibers.", "19.The wood floor of claim 14, wherein the first plurality of fibers, the second plurality of fibers, the third plurality of fibers, or a combination thereof include polymer fibers.", "20.A reinforced wood flooring for use in a vehicle, trailer, or container, the reinforced wood flooring comprising: a floor board having a bottom surface, a width, and a length; an underlay attached to the bottom surface of the floor board; wherein the underlay includes a plurality of randomly distributed fibers disposed within a thermoplastic material; wherein the underlay has a first flexural strength substantially along the length of the floor board and a second flexural strength substantially along the width of the floor board; wherein the first flexural strength and the second flexural strength of the underlay are designed to strengthen the floor board while simultaneously having a flexibility that allows the underlay to flex with the floor board substantially without at least partially separating from the floor board." ], [ "<SOH> BACKGROUND <EOH>Conventional truck trailers may utilize a wood flooring, for example hardwood flooring, because of the desirable characteristics that the flooring may provide the trailer.", "For example, hardwood flooring may have a desirable level of strength, stiffness and hardness.", "Of the known wood floorings, each has certain advantages and disadvantages.", "There is an ongoing need to provide additional floorings and methods for making and using floorings." ], [ "<SOH> SUMMARY <EOH>The disclosure describes design, material, manufacturing method, and use alternatives for reinforced floors for truck trailers and containers.", "An example reinforced wood flooring may include a wood member.", "The wood member may include a plurality of wood strips that are attached together.", "The wood member may also have a top surface and a bottom surface.", "An essentially water impermeable underlay may be adhered to the bottom surface of the wood member.", "Among fiber reinforced plastic (FRP) laminates, in some cases, fiber-reinforced thermoplastic (FRTP) laminates are more flexible in deflection than fiber-reinforced thermoset plastics (FRTSP) laminates at the same thickness and are lighter in weight (e.g., at the same thickness) but can provide significant improvements in flexural strength of the composite wood flooring.", "An FRTP laminate applied to an underside of the wood flooring can render the flooring essentially impermeable to water and other road contaminants.", "The reinforced floor may be used for truck trailers, containers, etc.", "An example reinforced wood flooring is disclosed.", "The reinforced wood flooring comprises: a floor board having a bottom surface; wherein the floor board has a length of 16 feet or longer and is suitable for use in a truck trailer or container; an essentially water impermeable underlay attached to the bottom surface of the floor board, the underlay comprising a plurality of fibers disposed within a thermoplastic resin; wherein the underlay has a thickness of about 0.1 inches or less and is designed to enhance the strength of the floor board while simultaneously having a flexibility that allows the underlay to flex with the floor board substantially without separating from the floor board.", "Alternatively or additionally to any of the embodiments above, the underlay is secured to the bottom surface of the floor board by adhesion.", "Alternatively or additionally to any of the embodiments above, the plurality of fibers comprise fiberglass fibers.", "Alternatively or additionally to any of the embodiments above, the underlay comprises about 70% or less by weight of fiberglass.", "Alternatively or additionally to any of the embodiments above, the underlay has a flexural strength of about 140,000 psi or less along a length of the floor board and a flexural strength of about 60,000 psi or less along a width of the floor board.", "Alternatively or additionally to any of the embodiments above, the underlay has a dyne level of 35 dyne/cm or more in surface energy.", "Alternatively or additionally to any of the embodiments above, the plurality of fibers in the underlay are arranged in a plurality of layers including a first layer where a first portion of the plurality of fibers are substantially aligned along a length of the floor board and a second layer where a second portion of the plurality of fibers are substantially aligned along a width of the floor board.", "Alternatively or additionally to any of the embodiments above, the plurality of layers in the underlay includes a third layer where a third portion of the plurality of fibers are substantially aligned along the length of the floor board.", "Alternatively or additionally to any of the embodiments above, the floor board has a strength in a three point bending test that fails at a flexural load of about 2,000 to 12,000 pounds of force.", "A flooring kit is disclosed.", "The flooring kit comprises: a plurality of floor boards, wherein each of the floor boards: has a length of 16 feet or longer and is suitable for use in a truck trailer or container, includes an essentially water impermeable underlay attached to a bottom surface of the floor board, the underlay comprising a plurality of fibers disposed within a thermoplastic resin, and wherein the underlay has a thickness of about 0.1 inches or less and is designed to enhance the strength of the floor board while simultaneously having a flexibility that allows the underlay to flex with the floor board substantially without separating from the floor board; and a binder securing together the plurality of floor boards.", "Alternatively or additionally to any of the embodiments above, the kit further comprises a set of instructions for assembling the floor boards as a floor for the truck trailer or container.", "Alternatively or additionally to any of the embodiments above, the underlay is secured to the bottom surface of the floor board by adhesion.", "Alternatively or additionally to any of the embodiments above, the plurality of fibers comprise fiberglass fibers and wherein the underlay comprises about 70% or less by weight of fiberglass.", "Alternatively or additionally to any of the embodiments above, the underlay has a flexural strength of about 140,000 psi or less along a length of the floor board and a flexural strength of about 60,000 psi or less along a width of the floor board.", "Alternatively or additionally to any of the embodiments above, the underlay has a dyne level of 35 or more dyne/cm in surface energy.", "Alternatively or additionally to any of the embodiments above, the plurality of fibers are arranged in plurality of layers including a first layer where a first portion of the plurality of fibers are substantially aligned along a length of the floor board and a second layer where a second portion of the plurality of fibers are substantially aligned along a width of the floor board.", "Alternatively or additionally to any of the embodiments above, the plurality of layers includes a third layer where a third portion of the plurality of fibers are substantially aligned along the length of the floor board.", "Alternatively or additionally to any of the embodiments above, each of the floor boards has a strength in a three point bending test that fails at a flexural load of about 2,000 to 12,000 pounds of force.", "Alternatively or additionally to any of the embodiments above, each of the floor boards has a length of 45 to 53 feet and is suitable for use in a truck trailer.", "A wood floor for a truck trailer is disclosed.", "The wood floor for a truck trailer comprises: a plurality of floor boards, wherein each of the floor boards is formed from a plurality of wood strips, each of the wood strips being adhesively secured together along their side surfaces and being secured together along their end surfaces; wherein each of the floor boards has a bottom surface; wherein each of the floor boards has a length of 45 feet or longer; an essentially water impermeable underlay attached to the bottom surface of each of the floor boards, the underlay comprising a plurality of fibers disposed within a thermoplastic resin; wherein the underlay has a thickness about 0.1 inches or less and is designed to enhance the strength of the floor board while simultaneously having a flexibility that allows the underlay to flex with the floor board substantially without separating from the floor board; wherein the underlay comprises about 70% or less by weight of fiberglass; wherein the underlay has a flexural strength of about 140,000 psi or less along a length of each of the floor boards and a flexural strength of about 60,000 psi or less along a width of each of the floor boards; and wherein each of the floor boards has a strength in a three point bending test that fails at a flexural load of about 2,000 to 12,000 pounds of force.", "The above summary of some embodiments is not intended to describe each disclosed embodiment or every implementation of the present invention.", "The Figures, and Detailed Description, which follow, more particularly exemplify these embodiments." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation of U.S. patent application Ser.", "No.", "15/230,830, filed Aug. 8, 2016, which is a continuation of U.S. patent application Ser.", "No.", "14/728,483, filed Jun.", "2, 2015, now U.S. Pat.", "No.", "9,434,421, the entire disclosure of which is hereby incorporated by reference.", "TECHNICAL FIELD The present disclosure pertains to reinforced wood flooring.", "More particularly, the present disclosure pertains to reinforced wood flooring for truck trailers and containers.", "BACKGROUND Conventional truck trailers may utilize a wood flooring, for example hardwood flooring, because of the desirable characteristics that the flooring may provide the trailer.", "For example, hardwood flooring may have a desirable level of strength, stiffness and hardness.", "Of the known wood floorings, each has certain advantages and disadvantages.", "There is an ongoing need to provide additional floorings and methods for making and using floorings.", "SUMMARY The disclosure describes design, material, manufacturing method, and use alternatives for reinforced floors for truck trailers and containers.", "An example reinforced wood flooring may include a wood member.", "The wood member may include a plurality of wood strips that are attached together.", "The wood member may also have a top surface and a bottom surface.", "An essentially water impermeable underlay may be adhered to the bottom surface of the wood member.", "Among fiber reinforced plastic (FRP) laminates, in some cases, fiber-reinforced thermoplastic (FRTP) laminates are more flexible in deflection than fiber-reinforced thermoset plastics (FRTSP) laminates at the same thickness and are lighter in weight (e.g., at the same thickness) but can provide significant improvements in flexural strength of the composite wood flooring.", "An FRTP laminate applied to an underside of the wood flooring can render the flooring essentially impermeable to water and other road contaminants.", "The reinforced floor may be used for truck trailers, containers, etc.", "An example reinforced wood flooring is disclosed.", "The reinforced wood flooring comprises: a floor board having a bottom surface; wherein the floor board has a length of 16 feet or longer and is suitable for use in a truck trailer or container; an essentially water impermeable underlay attached to the bottom surface of the floor board, the underlay comprising a plurality of fibers disposed within a thermoplastic resin; wherein the underlay has a thickness of about 0.1 inches or less and is designed to enhance the strength of the floor board while simultaneously having a flexibility that allows the underlay to flex with the floor board substantially without separating from the floor board.", "Alternatively or additionally to any of the embodiments above, the underlay is secured to the bottom surface of the floor board by adhesion.", "Alternatively or additionally to any of the embodiments above, the plurality of fibers comprise fiberglass fibers.", "Alternatively or additionally to any of the embodiments above, the underlay comprises about 70% or less by weight of fiberglass.", "Alternatively or additionally to any of the embodiments above, the underlay has a flexural strength of about 140,000 psi or less along a length of the floor board and a flexural strength of about 60,000 psi or less along a width of the floor board.", "Alternatively or additionally to any of the embodiments above, the underlay has a dyne level of 35 dyne/cm or more in surface energy.", "Alternatively or additionally to any of the embodiments above, the plurality of fibers in the underlay are arranged in a plurality of layers including a first layer where a first portion of the plurality of fibers are substantially aligned along a length of the floor board and a second layer where a second portion of the plurality of fibers are substantially aligned along a width of the floor board.", "Alternatively or additionally to any of the embodiments above, the plurality of layers in the underlay includes a third layer where a third portion of the plurality of fibers are substantially aligned along the length of the floor board.", "Alternatively or additionally to any of the embodiments above, the floor board has a strength in a three point bending test that fails at a flexural load of about 2,000 to 12,000 pounds of force.", "A flooring kit is disclosed.", "The flooring kit comprises: a plurality of floor boards, wherein each of the floor boards: has a length of 16 feet or longer and is suitable for use in a truck trailer or container, includes an essentially water impermeable underlay attached to a bottom surface of the floor board, the underlay comprising a plurality of fibers disposed within a thermoplastic resin, and wherein the underlay has a thickness of about 0.1 inches or less and is designed to enhance the strength of the floor board while simultaneously having a flexibility that allows the underlay to flex with the floor board substantially without separating from the floor board; and a binder securing together the plurality of floor boards.", "Alternatively or additionally to any of the embodiments above, the kit further comprises a set of instructions for assembling the floor boards as a floor for the truck trailer or container.", "Alternatively or additionally to any of the embodiments above, the underlay is secured to the bottom surface of the floor board by adhesion.", "Alternatively or additionally to any of the embodiments above, the plurality of fibers comprise fiberglass fibers and wherein the underlay comprises about 70% or less by weight of fiberglass.", "Alternatively or additionally to any of the embodiments above, the underlay has a flexural strength of about 140,000 psi or less along a length of the floor board and a flexural strength of about 60,000 psi or less along a width of the floor board.", "Alternatively or additionally to any of the embodiments above, the underlay has a dyne level of 35 or more dyne/cm in surface energy.", "Alternatively or additionally to any of the embodiments above, the plurality of fibers are arranged in plurality of layers including a first layer where a first portion of the plurality of fibers are substantially aligned along a length of the floor board and a second layer where a second portion of the plurality of fibers are substantially aligned along a width of the floor board.", "Alternatively or additionally to any of the embodiments above, the plurality of layers includes a third layer where a third portion of the plurality of fibers are substantially aligned along the length of the floor board.", "Alternatively or additionally to any of the embodiments above, each of the floor boards has a strength in a three point bending test that fails at a flexural load of about 2,000 to 12,000 pounds of force.", "Alternatively or additionally to any of the embodiments above, each of the floor boards has a length of 45 to 53 feet and is suitable for use in a truck trailer.", "A wood floor for a truck trailer is disclosed.", "The wood floor for a truck trailer comprises: a plurality of floor boards, wherein each of the floor boards is formed from a plurality of wood strips, each of the wood strips being adhesively secured together along their side surfaces and being secured together along their end surfaces; wherein each of the floor boards has a bottom surface; wherein each of the floor boards has a length of 45 feet or longer; an essentially water impermeable underlay attached to the bottom surface of each of the floor boards, the underlay comprising a plurality of fibers disposed within a thermoplastic resin; wherein the underlay has a thickness about 0.1 inches or less and is designed to enhance the strength of the floor board while simultaneously having a flexibility that allows the underlay to flex with the floor board substantially without separating from the floor board; wherein the underlay comprises about 70% or less by weight of fiberglass; wherein the underlay has a flexural strength of about 140,000 psi or less along a length of each of the floor boards and a flexural strength of about 60,000 psi or less along a width of each of the floor boards; and wherein each of the floor boards has a strength in a three point bending test that fails at a flexural load of about 2,000 to 12,000 pounds of force.", "The above summary of some embodiments is not intended to describe each disclosed embodiment or every implementation of the present invention.", "The Figures, and Detailed Description, which follow, more particularly exemplify these embodiments.", "BRIEF DESCRIPTION OF THE DRAWINGS The invention may be more completely understood in consideration of the following detailed description of various embodiments of the invention in connection with the accompanying drawings, in which: FIG.", "1 is a perspective overview illustrating a reinforced floor disposed in a truck trailer; FIG.", "2 is a perspective view of a traditional laminated wood floorboard with shiplaps and crusher beads; FIG.", "3 is a perspective view of an FRTP-reinforced wood floorboard with shiplaps and crusher beads; FIG.", "4 is a side view for a layup of an FRTP laminate with a five-ply structure; FIG.", "5 is a bottom view of an intermediate ply which consists of a fiberglass strand mat with a 90° orientation of unidirectional fibers, perpendicular to the orientation of the fibers in adjacent plies; FIG.", "6 is a bottom view of an alternative intermediate ply which includes a woven fabric mat of 0° and 90° crisscrossing fibers; and FIG.", "7 is a bottom view of another example of an intermediate ply which includes a nonwoven fabric mat; FIG.", "8 is a perspective view of a floor kit; and FIG.", "9 is a graph illustrating a relationship between the flexural strength of an FRP underlay at different thicknesses and structures, and the strength increase of FRP-reinforced wood flooring versus conventional wood flooring at the same board thickness.", "While the invention is amenable to various modifications and alternative forms, specifics thereof have been shown by way of example in the drawings and will be described in detail.", "It should be understood, however, that the intention is not to limit the invention to the particular embodiments described.", "On the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.", "DETAILED DESCRIPTION For the following defined terms, these definitions shall be applied, unless a different definition is given in the claims or elsewhere in this specification.", "All numeric values are herein assumed to be modified by the term “about,” whether or not explicitly indicated.", "The term “about” generally refers to a range of numbers that one of skill in the art would consider equivalent to the recited value (e.g., having the same function or result).", "In many instances, the terms “about” may include numbers that are rounded to the nearest significant figure.", "The recitation of numerical ranges by endpoints includes all numbers within that range (e.g.", "1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, and 5).", "As used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include plural referents unless the content clearly dictates otherwise.", "As used in this specification and the appended claims, the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.", "In some instances, use of the phrase “wood member” may refer to a laminated wood floor for trailers and containers.", "A laminated wood floor includes a plurality of laminated floorboards.", "As discussed herein, a reinforcing fiber may also be referred to simply as a fiber.", "A variety of reinforcing fibers may be used.", "In some cases, a reinforcing fiber may be a fiberglass fiber, which in some instances may be referred to simply as a glass fiber.", "Fiber reinforced plastics (FRP) refers generally to reinforced plastic materials, including but not limited to fiber-reinforced thermoplastics (FRTP).", "A thermoplastic is a matrix in FRTP and may also be called a thermoplastic resin or a resin.", "An FRP underlay refers to a FRP laminate which may be termed an FRTP laminate.", "It can also be called a reinforced underlay.", "For this disclosure, an FRP underlay is a fiber-reinforced sheet material and is also called FRP sheet.", "A composite floorboard may be a fiber-reinforced composite floorboard (e.g., an FRP-reinforced wood floorboard).", "Composite wood flooring or reinforced wood flooring may also be referred to as composite wood floorboards.", "A composite wood floorboard may also be called a composite floorboard or a composite board.", "The following detailed description should be read with reference to the drawings in which similar elements in different drawings are numbered the same.", "The drawings, which are not necessarily to scale, depict illustrative embodiments and are not intended to limit the scope of the invention.", "FIG.", "1 is a perspective view of an example reinforced wood flooring 10.In this example, flooring 10 is disposed in a truck trailer 12.Although flooring 10 is illustrated within trailer 12, this is not intended to limit the invention as flooring 10 may be used, for example, with a number of different structures including containers (e.g., shipping and/or freight containers), railroad box cars, and the like, or any other suitable structure.", "Trailer 12 may be structurally similar to typical truck trailers known in the art.", "For example, trailer 12 may have a pair of opposing side walls 14 and end doors 16 that can open and close to provide access to the interior of trailer 12.In at least some embodiments, flooring 10 may extend across the width and along the length of the interior of trailer 12.Trailer 12 may have a plurality of support members 18 (e.g., “I” beams, “C” beams, hat sections, etc.)", "that each may have an upper flange or surface that crosses the width of trailer 12 and are spaced along the length of trailer 12.In some embodiments, flooring 10 may be secured to support member 18 by screws (not shown) or any other suitable fasteners, which may penetrate through the whole thickness of flooring 10 and the upper flange of support members 18.As indicated above, flooring 10 may be a reinforced wood flooring.", "By virtue of being reinforced, flooring 10 may be designed to have a desirable level of strength, stiffness, and the like.", "This may be desirable for a number of reasons.", "For example, increased strength may allow flooring 10 to be more resistant to damage and/or wear, carry greater loads (e.g., increase payload), have a greater life, etc.", "Furthermore, by virtue of using a reinforcing structure (e.g., the “reinforcing underlay” such as underlay 24 described below) in flooring 10, other components of flooring 10 (e.g., the “wood member” such as wood member 22 described below) may be manufactured to be thinner, which may decrease the weight of flooring 10 and improve the fuel economy in trailers using flooring 10.Some additional details regarding these and other features can be found below.", "As suggested above, in at least some embodiments, flooring 10 may include one or more floorboards or wood members 22 and a reinforcing member or underlay 24 disposed along a bottom surface 23 of each wood member 22 as shown in FIGS.", "1 to 3.Wood member 22 may take the form of a floor board of flooring component that is made from a suitable hardwood such as oak, maple, ash, birch, beech, aspen, elm, poplar, and the like, or any other suitable hardwood.", "Hardwoods may be desirable, for example, due to their high strength, stiffness, hardness, and excellent durability.", "Alternatively, some softer woods may also be used, where appropriate.", "Wood member 22 may include a plurality of wood strips 28 that are fastened together.", "For example, wood strips 28 are arranged in a side-to-side and end-to-end manner in order to form wood member 22.To manufacture the individual strips 28, green (e.g., not dried) wood logs may be cut into lumber using conventional techniques.", "The lumber may be kiln-dried so that it has an equivalent moisture content of about 6 to 10%.", "Alternatively, the lumber may be seasoned or otherwise allowed to dry to the desired moisture content.", "The dried lumber may be sanded and planed into the desired thickness.", "For example, the lumber may be sanded and planed so that it has a thickness of about 0.75 to 1.5 inches, or about 1 to 1.25 inches thick.", "The lumber may also be cut into the desired width, for example, using a ripsaw.", "For example, the lumber may be cut to have a width of about 0.75 to 2 inches, or about 1 to 1.438 (e.g., 1 7/16) inches wide.", "During the manufacturing of strips 28, any wood defects such as knots, cracks and fractures, bark pockets, cavities and holes by insects, decay by fungi, and stains by molds may be removed by cutting off the defects with, for example, a chop saw or suitable automatic cutting system.", "It can be appreciated that such cutting may alter the length of strips 28.It may be desirable for minimum length of wood strips 28 to be about 12 inches in wood member 22.Overall, the average length of wood strips 28 may be between about three and three and one-half feet.", "Both of the opposing ends of each wood strip 28 may be cut into a square shape with, for example, a tennoner saw.", "The squared ends of wood strips 28 may also be further cut so that “hooks” are formed therein.", "These hooks allow wood strips 28 to be attached end-to-end by mating adjacent hooks and forming a “hook joint” 27.The depth or size of hook joint 27 may vary depending on the application.", "For example, the depth of hook joints 27 may be about 0.25 to 0.75 inches, or about 0.25 to 0.5 inches, or about 0.375 inches.", "Alternatively, any other suitable type of joint may be utilized to join together wood strips 28.In some instances, hook joint 27 may be sealed with a suitable sealing material.", "The suitably prepared wood strips 28 may also be fastened together side-to-side using a suitable attachment technique.", "For example, the vertical sides or edges of each wood strip 28 may be coated with an adhesive by a roller glue spreader.", "This may help secure wood strips 28 across the width of wood member 22.A suitable adhesive for this securing may include melamine formaldehyde, urea-melamine formaldehyde, crosslinking polyvinyl acetate, isocyanate, and the like.", "The glue-coated wood strips 28 may be assembled (e.g., both side-to-side and end-to-end) on a conveyor.", "This may include manual assembly.", "The hook joints 27 may fasten together the adjacent ends of strips 28 to form a continuous slab, in which they are jointed end-to-end in a number of rows (as illustrated in FIG.", "2).", "It may be desirable to control the number of hook joints 27 per square foot.", "For example, it may be desirable to have about 5 to 7 hook joints 27 per square foot on average.", "The joined collection of wood strips 28 may be placed into a steam or radio frequency hot press under vertical and cross-direction pressures for curing of the adhesive.", "Once strips 28 are secured together in the desired fashion, the resultant board may be cut to the desired length.", "For example, the board may be cut to a length of about 16-60 feet, or 28-56 feet, or 45-54 feet, or about 56 feet (or more or less depending on the application).", "Such lengths may be suitable for use in, for example, a truck trailer or container.", "Additionally, the board may also be divided into a number of floorboards or wood members 22 that each has a width, for example, of about 10 to 14 inches or about 12 inches to 12.25 inches.", "These wood members 22 may be planed (and/or sanded) to a desired thickness.", "For example, wood member 22 may be planed to a thickness of about 1 to 1.5 inches, or about 1.125 inches, or about 1.313 inches, or about 1.375 inches, etc.", "Trailers like trailer 12 may include a plurality of wood members 22 joined together to form flooring 10.For example, trailer 12 may include about 6 to 10 wood members 22, or about 8 wood members 22, or more or less depending on the application.", "To facilitate the joining of wood members 22, shiplaps 25 and crusher beads 26, which may be similar to those known in the art, may be machined on to both edges of each wood member 22 (FIG.", "2).", "Shiplaps 25 may be convenient for installing floorboards on truck trailers by allowing adjacent wood members 22 to overlap.", "Crusher beads 26 may provide spaces between adjacent wood members 22, which may protect members 22 from buckling due to their expansion in wet conditions.", "In some embodiments, bottom surface 23 of wood members 22 may be coated with a water resistant polymeric layer (e.g., latex).", "However, this may not be necessary when underlay 24 is utilized (FIG.", "3).", "Wood members 22 may be sealed at both ends with a water resistant adhesive or a wax emulsion.", "To avoid the water or moisture penetration from both ends of reinforced wood flooring 10, a water resistant adhesive resin such as epoxy and crosslinking polyvinyl acetate may also be used at the ends of wood members 22.The top surface of wood members 22 may be optionally coated with a suitable epoxy, lacquer, wax emulsion, or varnish to improve the durability and water resistance of wood members 22 during installation and maintenance.", "As indicated above, wood members 22 may include underlay 24 along bottom surface 23.Underlay 24 may be essentially water impermeable.", "More particularly, underlay 24 may essentially prevent water (including liquid water and/or water vapor) from passing therethrough.", "Accordingly, using a water impermeable underlay 24 may be desirable because it may form a water barrier at the bottom of flooring 10, where flooring 10 would otherwise be exposed to the outside environment.", "In addition, underlay 24 may include a structure that may add desired strength to wood member 22.This may be desirable for a number of reasons.", "For example, adding strength may improve wear resistance, extend life, increase the payload of a trailer (e.g., trailer 12), etc.", "In at least some embodiments, underlay 24 includes a fiber reinforced thermoplastic (FRTP).", "An FRTP may include a plurality of reinforcing fibers that are impregnated with or otherwise include a polymeric resin or matrix.", "The fibers may be carbon fibers, glass fibers, aramid fibers (e.g., Kevlar® by DuPont & Co.), and the like, or mixtures and/or combinations thereof.", "In some cases, the fibers may be fiberglass fibers such as E-glass, S-glass, C-glass or other glass fibers.", "The fibers may make up about 10-80%, or about 20-70%, or about 30-60% or about 60% of the weight of underlay 24.The polymeric resin or matrix may include one or more thermoplastic resins such as polypropylene (PP), polyethylene (PE), polyvinyl chloride (PVC), polycarbonate (PC), polyesters such as polyethylene terephthalate (PET), polyethylene terephthalate glycol (PETG), and polybutylene terephthalate (PBT), polyamide (also called nylon, e.g., nylon 6, nylon 6/6, and nylon 12), polyether ether ketone (PEEK), polyphenylene sulfide (PPS), polysulfone (PSUL), polyamide imide (PAI), polyether imide (PEI), acrylic, polyvinyl alcohol, polyacetals, ethylene vinyl acetate (EVA) or the like, or any other suitable polymeric materials.", "The FRTP may be manufactured according to conventional manufacturing processes such as pultrusion.", "Underlay 24 may also vary in thickness.", "In some embodiments, underlay 24 may be about 0.003 to about 0.1 inches thick, or about 0.01 to about 0.04 inches thick, or about 0.05 to 0.09 inches thick, or about 0.030 inches thick.", "Underlays 24 of these thicknesses may provide a suitable degree of reinforcement while being sufficiently thin so as to reduce the overall weight of flooring 10.This may desirably impact the properties of flooring 10 by reducing the weight, which may allow for less fuel consumption when transporting goods to while allowing them to carry just as much or more goods (i.e.", "increase payload).", "Furthermore, FRP underlays 24 may reinforce wood member 22 sufficiently so that wood members 22 may be further thinned, which also may desirably reduce the weight of flooring 10 while still maintaining a desirable amount of strength.", "In some instances, it may be desirable for underlay to add a sufficient amount of strength while still maintaining enough flexibility for wood members 22 to bend without separating from the underlay 24.For example, an underlay with a larger amount of stiffness/strength may provide good strength properties but may have a greater potential for separation, which could allow for water intrusion onto wood members 22.Therefore, a desired balance between strength and flexibility may allow flooring 10 to have superior performance without sacrificing (and even increasing) durability.", "In some embodiments, underlay 24 may be attached to wood member 22 using a suitable thermosetting or thermoplastic adhesive or adhesive layer.", "In some instances, essentially the entire bottom surface of wood member 22 is adhesively bonded to underlay.", "In other instances, a discontinuous layer of adhesive and/or a discontinuous glue pattern (which may also be termed a “glueline” in the art) may be understood to be a layer of adhesive or a glue pattern that is designed to cover less than all of the surface area of bottom surface of wood members 22.For example, the discontinuous layer of adhesive may cover less than 100% of the surface area of the bottom surface of wood members 22, or about 98% or less, or about 96% or less, or about 95% or less, or about 90% or less of the surface area of the bottom surface of wood members 22.A discontinuous layer of adhesive differs from a continuous layer of adhesive (and/or continuous glueline), which is designed to cover essentially 100% of the surface area of a wood member surface.", "It will be appreciated that a variety of different discontinuous glue patterns are contemplated, including but not limited to those described and illustrated in U.S. Pat.", "No.", "7,765,758, the entire contents of which are incorporated by reference in their entirety.", "In other instances, a continuous layer of adhesive may be utilized.", "A variety of adhesives may be used.", "For example, illustrative thermosetting adhesives may include epoxy, polyurethane, phenol-resorcinol formaldehyde, etc., while thermoplastic adhesives may include ethylene vinyl acetate (EVA), polyamide, cyanoacrylate (CA), and hot melt polyurethane (PUR), or any other suitable adhesives.", "It should be noted that while the following discussion describes the use of PUR in flooring 10, this is not intended to limit the invention as essentially any other suitable adhesive may be used for the adhesive layer.", "In at least some embodiments, the PUR adhesive may be placed on a reservoir adjacent a pair of heated rollers.", "The temperature of rollers may be controlled to be between about 250° F. and about 300° F., which may melt the PUR material.", "After the PUR resin is completely melted, wood members 22 may pass through a gap between the rollers and wood members 22 are coated with the PUR material.", "Underlay 24 may be quickly laid on the glueline (e.g., the layer of PUR material disposed on wood members 22) and pass through a pair of cool rollers (also called pinch rollers) under pressure.", "The pressure of the pinch rollers may be adjusted to achieve a desirable bonding strength as well as the desired distribution of adhesive (e.g., avoiding and/or limiting “pinch out” or “squeezing out” of adhesive).", "The resultant reinforced wood flooring 10 is stored at room temperature for 24 hours to complete further solidification and/or curing of the PUR.", "The FRP edges of the cured reinforced wood flooring 10 may be trimmed with a suitable cutting tool to remove any excess material.", "This may form the reinforced wood flooring 10 (and/or one of the floor boards making up flooring 10).", "In some cases, it may be challenging to strongly bond a thermoplastic matrix onto a wood substrate since many of the commercial thermoplastics have a relatively low surface energy.", "Low surface energy of a substrate usually results in poor bonding by an adhesive due to the difficulty of wetting out.", "Accordingly, in some cases it may be desirable for an FRTP laminate to have a surface energy ranging from about 40 dyne/cm to about 50 dyne/cm.", "In some cases, for thermoplastic matrices which have a surface energy that is lower than 40 dyne/cm, the bonding surface of FRTP underlay 24 can be plasma- or corona-treated during manufacture of FRTP before the lamination process in order to ensure strong interfacial adhesion.", "Unfortunately, in some cases, the plasma- and/or corona-initiated surface energy can only last for three to six months, as the dyne level of the treated FRTP surface gradually reduces in a natural atmosphere.", "Alternatively, the FRTP surface can be directly roughened by using a sanding machine or other abrasion facilities.", "Since in some cases FRTP is a soft material, it may not be easy to be deeply sanded like a rigid FRTSP material.", "Accordingly, in some cases, it may be useful to use a “micro-sanding” process, in which one of outer surfaces is slightly roughened to remove a mold release agent on the top layers of FRTP, such that the roughened surface can be used as a bonding surface for FRTP.", "In addition, a combination of the plasma and/or corona treatment and the “micro sanding” method may be used to achieve a better bonding outcome for FRTP.", "In another alternative process, a scrim method can be used to improve the roughness of some thermoplastics.", "A scrim is a fabric which is attached on the outer surface of an FRTP material during manufacture.", "The scrim may be impregnated with the resin matrix and then solidified to become one of the outer surfaces for FRTP.", "The scrim method is useful for some FRTP laminates which are difficult to bond as the scrim can desirably create a roughness of FRTP after an abrasion treatment such as sanding.", "The roughened scrim may be used as the bonding surface of FRTP for further lamination.", "For instance, FRTP laminates may be bonded through the scrim by an adhesive such as hot melt PUR onto the wood member 22.The reinforcing fibers used in the FRTP laminate may be continuous and/or discontinuous.", "The continuous fibers may be monofilament or multifilament.", "The multifilament fiber can be twisted or untwisted.", "Continuous fibers may be used in a pultruded or laminated structure, while discontinuous fibers may be directly mixed with the thermoplastic matrix, or formed to a planar mat by combining with a binder.", "Compared to the discontinuous fibers, continuous fibers are precisely controlled in fiber orientation.", "However, the discontinuous fibers may have a limited length.", "Discontinuous fibers can be divided into two groups: One is called short fibers, while the other is called long fibers.", "For example, the fiber length of short fiber is usually less than 1 inch, whereas long fibers can be about 2 inches or more in length.", "Sometimes short fibers are also called ultrashort or milled fibers when they have a fiber length of less than 0.125 inches.", "The ultrashort fibers are normally suitable for injection molding and sheet extrusion applications.", "In addition, short fibers mostly used for discontinuous fiber-based FRTP laminates are usually recommended to have a length to diameter ratio of about 500:1 to 800:1.The fiber architecture (e.g.", "the arrangement of fibers) in the underlay 24 may vary.", "In FRTP, the reinforcing fibers normally have a certain reinforcement format.", "For example, continuous fibers can exist individually as roving, filament, or strands in the thermoplastic matrix of FRTP.", "They can also be a plain weave, a basket weave, a till weave, a satin weave, a multi-axial weave, and the like.", "These weave materials are also called continuous textile fiber mats.", "In some weaves, the fibers are crisscrossed in 0 and 90 degree directions, respectively.", "Within a weave, the fiber aligned along or close to the longitudinal direction and/or the length of the weave is called “warp”, while that aligned along or close to the transverse direction and/or the width of the weave is called “weft” (sometimes “woof”).", "In some situations, two different fibers can be woven together to form a hybrid weave.", "Of course, there are also other kinds of continuous fiber mats used for FRTP, including stitched fabrics, continuous random mats (CRM) which include nonwoven fabrics, knitted fabrics, braided fabrics, etc.", "Discontinuous fibers are usually compounded with a thermoplastic matrix and randomly distributed in FRTP sheet.", "A discontinuous random mat can also be pre-formed before the thermoforming process, which is usually a nonwoven fabric.", "A nonwoven fabric may include continuous or discontinuous fibers arranged in a two-dimensional sheet (or web).", "Unlike a regular cloth, it is neither woven nor stitched.", "Since a nonwoven fabric is low in cost and can provide effective reinforcement for some applications, it can be used as a preform in FRTP materials.", "In some embodiments, most of the fibers may be oriented in the same direction (e.g., the longitudinal direction).", "Alternatively, some of the fibers in underlay 24 may be oriented in one direction while some of the fibers may be disposed in a different direction such as, for example, perpendicularly to those fibers.", "For example, underlay 24 may include about 70% or more of the fibers oriented in the longitudinal direction and the balance of them arranged perpendicular to those fibers, or about 80% or more of the fibers oriented in the longitudinal direction and the balance of them arranged perpendicular to those fibers, or about 90% or more of the fibers oriented in the longitudinal direction and the balance of them arranged perpendicular to those fibers.", "In some other embodiments, underlay 24 can have a single ply or layer of FRTP material, in which the continuous fibers are orientated in the longitudinal direction (e.g., along the length of trailer 12) for the ultimate performance.", "Alternatively, the fibers can be discontinuous fibers (e.g., chopped fibers).", "The chopped fibers can be randomly distributed in a matrix and form a single layer of FRTP within the matrix.", "In some cases, the chopped fibers may have a length ranging from about 0.25 inches to about 4 inches.", "In some instances, underlay 24 can include a plurality of layers or plies.", "For example, FIG.", "4 shows an example of a five-ply FRTP structure, in which all fibers are bonded by a resin matrix 32.In this example, the first, third and fifth plies 30 may be a strand mat, in which all fibers are aligned in the longitudinal direction, while the plurality of fibers in the intermediate plies 31 may be oriented in a direction different from those in adjacent plies (e.g., perpendicular to the fibers in the first, third and fifth plies 30).", "Alternatively, the plurality of fibers in the intermediate plies 31 (and/or the first, third and fifth plies 30) can have two dimensional (2D) or three dimensional (3D) structures.", "These arrangements may result in a solid and strong structure for FRTP.", "In some cases, the FRTP laminates may be as simple as a two-ply laminate in which the fiberglass of the outer ply or the top ply may be aligned in the longitudinal direction, while the fiberglass of the intermediate ply may be perpendicular to that in the outer ply.", "The intermediate ply may directly contact the wood substrate.", "Of course, the FRTP laminates can also be 3 plies or more (e.g., similar to that shown in FIG.", "4 but with only 3 layers), depending on design and performance requirements.", "In some cases, the intermediate plies 31 may be a one-dimensional layup.", "As shown in FIG.", "5, the intermediate plies 31 may be a strand mat 130 with continuous fibers that are arranged in an orientation angle of 90 degrees and perpendicular to the fibers in the adjacent strand mats 30 (e.g., the first, third and fifth plies) with an orientation angle of 0 degrees.", "Alternatively, the intermediate plies 31 may be a two- or three-dimensional layup.", "For example, in some embodiments, the intermediate plies 31 may be a fabric material.", "As shown in FIG.", "6, the fibers of the strand mat 230 may be knitted with a woven structure in which they are crisscrossed with twisted 0 degree and 90 degree bidirectional orientations and are buried in the resin matrix 232.The bidirectional fibers can also extend at a relative orientation of about 30 degrees, about 45 degrees or about 60 degrees relative to those in adjacent layers.", "In some cases, the different braiding structures may be replaced with a stitching structure, in which strand fibers are tightly stitched with a thermoplastic tread or string such as nylon, polyester and the like at the intersections to form different bidirectional orientations.", "In some cases, as shown in FIG.", "7, the strand fibers can use a nonwoven fabric for the intermediate plies 31.The fiber of the strand mat 330 are completely randomly distributed in the resin matrix 332.In at least some embodiments, FRTP can be a combination of different fiber shapes, orientations, and configurations.", "For example, a three ply FRTP material may include a continuous strand mat for the top and bottom plies, respectively, and a nonwoven structure for the intermediate ply.", "Similarly, the top and bottom plies may be a continuous strand mat, respectively, while the intermediate ply may be a mat with randomly distributed discontinuous fibers.", "In some instances, the top and bottom plies may be a fiber mat in which the chopped fibers are arranged in the longitudinal direction, while the intermediate ply may be either a woven or a nonwoven mat.", "In some instances, a hybrid fiber structure may exist in the underlay 24.For example, the underlay 24 may include a combination of glass fibers and aramid fibers.", "These fibers may be divided such that a ratio of glass fibers to aramid fibers, by weight, may be about 8:1 to 100:1, or about 30:1 to 80:1, or about 50:1.In some cases, an illustrative underlay 24 may include about 60-65% by weight glass fibers and about 1-10% or about 5-10% by weight aramid fibers.", "In a particular example, an underlay 24 may include about 63% by weight glass fibers and about 7% by weight aramid fibers.", "It will be appreciated that other ratios are contemplated.", "It will also be contemplated that while these illustrative ratios are given in terms of weight percent, it is possible to express the fiber ratios in a corresponding volume ratio.", "In some cases, FRTP (thermoplastic) laminates have certain advantages compared with FRTSP (thermoset plastic) laminates.", "Firstly, FRTP is lighter in weight, which can reduce the weight of composite flooring and accordingly, reduce fuel costs during transportation.", "Secondly, FRTP provides improved mechanical properties such as toughness and chemical and water resistances.", "Thirdly, most of the thermosetting based FRTSP laminates require a curing step for the resin within an autoclave device, but FRTP has no curing requirements for a thermoplastic.", "This may provide potential automation for FRTP.", "Because thermoplastics tend to be softer than thermoset plastics, the desirable benefits and performance of FRTP laminates are unexpected (e.g., the performance is unexpectedly better than predicted).", "As another advantage, FRTP laminates can be easily reformed and reprocessed like thermoplastics.", "For example, the size of FRTP sheet materials can be easily expanded by splicing two FRTP sheets together or directly end-joining two separate FRTP sheets under a high temperature and a high pressure.", "Unlike thermosetting based FRTSP laminates, hence, short FRTP sheet materials can be reused, thus reducing wastes and their impact to the environment.", "In addition, this reformable property makes it easy to form various multiple-ply FRTP products from preforms and prelaminates that are the intermediate products of FRTP laminates.", "In some instances, FRTP is a flat sheet material that can be manufactured with continuous or discontinuous fibers in different thermoplastic matrices.", "The basic manufacturing process for FRTP includes mixing and/or compounding the fibers with a thermoplastic resin, preforming an assembly, melting the resin, and finally consolidating the composite.", "As aforementioned, the preforms fabricated after the preforming step are also called an intermediate product of FRTP laminates that are converted into a final product in a later processing step.", "In some cases, fabrication of FRTP sheet materials includes the manufacturing processes for FRTP laminates reinforced with continuous fibers and those with discontinuous fibers.", "In general, an FRTP underlay 24 reinforced with continuous fibers can be manufactured by following a process for continuous fiber-reinforced composite laminates.", "For example, a unidirectional tow or tape process may be used to manufacture a FRTP sheet material.", "At the first step, creels of a reinforcing fiber such as fiberglass, carbon fiber, aramid fiber or the combination of the above fibers thereof firstly pass a spreading device in order to align the fiber's filaments in the machine direction and reduce the amount of crossovers in the transverse direction.", "At the same time, the spreading device helps open up the fiber bundle for better wetting out by the resin matrix during the impregnation step.", "The spread fiber may move into an impregnation chamber, in which the thermoplastic resin is melted as a molten polymer at a temperature of about 50-120 degrees F. higher than the melting point of the resin matrix.", "The assembly enters a consolidator or continuous press under a high pressure to remove any air bubbles and reduce any voids existing in the FRTP laminates.", "A solid FRTP sheet is formed after it is released from a series of cooling rolls.", "Alternatively, the fiber bundle or mat can be overlapped with a thin resin sheet on its top and bottom surface, respectively, and passed through a pair of setup rollers and a series of solidification rollers.", "The assembly is heated up in a heater and released after it cools down by passing through a series of cooling rolls.", "In some cases, a processing temperature, also referred to as a consolidating temperature, is about 50 to 120° F. higher than the melting temperature of the thermoplastic matrix resin.", "The cooling temperature may be controlled to be slightly higher than or close to the glass transition temperature Tg of the thermoplastic resin.", "Similarly to the above process, FRTP sheet materials can also be fabricated by using a pultrusion process.", "During pultrusion, continuous fibers fed by creels and/or spools are impregnated with a thermoplastic resin in a bath or a spray chamber.", "The fiberglass wetted with the resin is formed as a sheet within a heated pultrusion die under shear/compression stress.", "The FRTP sheet is then pulled out with a pulling device.", "The pulling speed usually depends upon the resin system and the size and dimension of the FRTP sheet.", "Finally, the resultant FRTP sheet passes through a series of cooling rollers.", "In an alternative process, a melted thermoplastic matrix is fed into the contact area of two preformed fiber mats by an extruder through a nip that covers the whole width of the mats.", "At the same time, a sheet of the same thermoplastic resin is placed on the outer surfaces of both fiberglass mats, respectively.", "The assembly of the above processes enters a heat laminator and is instantly formed as a sheet material under a high temperature and a high pressure.", "The heat laminator normally consists of a top and a bottom steel belt conveyor, respectively (also known as a belt press).", "The top and bottom steel belts are heated up by a heating unit located in the top and bottom conveyor, respectively.", "After being fed into the open gap of both conveyors of the belt press, the layup is heated up and squeezed down under a high temperature and a high pressure until it is consolidated.", "Finally, the above preforms may be further laminated into a FRTP laminate with different fiber arrangements and ply structures with a laminator as aforementioned.", "Alternatively, a compression or matched die molding technique can be used to produce FRTP sheet materials.", "The equipment of compression molding is usually a hydraulic press and can apply a pressure up to several hundred tons.", "Similarly to the above process, this technique is normally combined with preforms or prelaminates.", "Accordingly, this system is often used for the final formation or preform materials such as sheet molding compound (SMC) or bulk molding process (BMC).", "These preforms are often provided from an industrial supplier.", "Although the compression molding process is periodic, the resultant FRTP sheet is continuous.", "The hydraulic press usually has a single daylight opening system (i.e., one opening gap with two platens) in order to manufacture of continuous FRTP sheet materials.", "Finally, the resultant FRTP sheet is released from the press and rolled up for shipping.", "For the above manufacturing processes for continuous fiber FRTP laminates, a good example is Polystrand Inc.'s E-glass reinforced PETG sheet material which has a sandwich structure (also see Example 1).", "All plies of the reinforced PETG sheet use a strand mat.", "The fibers in the top and bottom layers may be orientated in the longitudinal direction, while the fibers in the intermediate ply are perpendicular to those in the top and bottom layers.", "The flexural strength of the resultant sheet composite is about 110,000 psi in the longitudinal direction and about 40,000 psi in the transverse direction.", "The fiber ratio is about 60%.", "FRTP laminates reinforced with discontinuous fibers may be manufactured with different processes for random fiber-reinforced sheet composites.", "Some typical processes are included as below, but the manufacture methods are not limited to these processes.", "For example, a dry process for random fiber sheet can be used to manufacture FRTP sheet materials with discontinuous fibers.", "This method uses a continuous melt impregnation technique in which discontinuous fibers are randomly laid down on a moving belt on which a resin is directly extruded as film.", "The assembly passes through a nip or belt press and is consolidated into a sheet product with a nominal thickness.", "Finally, the resultant sheet material is further solidified with a series of cooling rolls and cools down to room temperature.", "FRTP may also be fabricated by using a water slurry manufacturing approach in which the short fibers are mixed with the resin in powder or fiber form in a papermaking machine.", "Since a large amount of water is used, this provides a uniform dispersion of short fibers in the assembly.", "During mixing, some additives such as surfactants, dispersing agents, antifoaming agents and the like may be added in the slurry to prevent segregation.", "The fiber/resin assembly then passes vacuum slots to remove water and may pass at least one of a forced-air dryer and an IR heater to remove additional water.", "Finally, the resultant sheet product passes a calendar and is rolled up.", "Alternatively, FRTP with discontinuous fibers can be manufactured with a sheet extrusion system.", "The fiber strands may be chopped into a length of about 0.25 inches and may be compounded with a thermoplastic such as nylon, PP, PVC, and other suitable thermoplastic resins.", "During the compounding process, a number of additives such as a dye, a coupling agent, a lubricant, and so on can be added into the mixed blend.", "The blends can be directly sent to the sheet extrusion system or they can be cooled down and granulated as pellets.", "In the sheet extrusion system, the melt is pushed through a die to form a continuous FRTP sheet material.", "The sheet material is rolled up after it cools down.", "Eleison Composites LLC's GComp is an illustrative but non-limiting example of random fiber-reinforced sheet composites (also see Example 3).", "GComp is a long E-glass fiber-reinforced PP sheet material.", "The chopped E-glass fiber in GComp is about 2 inches to 3 inches in length, and it is randomly distributed in FRP.", "GComp is about 0.040 inches in thickness and has a fiber ratio of up to about 50%.", "The longitudinal flexural strength of GComp is in a range between about 10,000 psi to about 12,000 psi.", "In some cases, it is useful for a thermoplastic matrix to maintain an appropriate flow behavior during the impregnation process.", "The viscosities for thermoplastics are generally higher at the processing temperature than those of the thermosets.", "For example, the processing temperature for PPS, PET, PP and nylon 6/6 thermoplastic are recommended to be about 600° F., about 560° F., about 400° F. and about 550° F., respectively.", "At the required processing temperature, the viscosity of PPS is normally about 25,000 P (e.g., Poises), while PET is about 1,300 P. For comparison, an epoxy thermoset resin is only about 1,000 P at room temperature during the impregnation process.", "Hence, it may be useful to use various forms of thermoplastic resins for pre-form or pre-lam manufacture in order to meet the viscosity and processing temperature challenges for the melt impregnation process.", "The major impregnation methods for FRTP may include dry powder, commingled fiber, slurry, direct melt or film coating, depending on the availability of the resin form, the intended end use of the intermediate form, and the overall process economics.", "In dry powder impregnation, the thermoplastic resin is attached on the fiber with a form of powder by a fluidization method, including direct gas fluidization, aerosolization, and electrostatic fluidization.", "In general, the powder size of the resin matrix is less than 8 μm since the fiber diameters are usually in the range between about 8 to about 12 μm.", "In a commingled fiber impregnation process, the reinforcing fiber is intermixed with the resin in fiber form.", "For example, a fabric web of both fibers is mixed by texturing and interlacing the filaments of fiber bundles with the resin fibers, resulting in fiber-resin entanglement.", "For the slurry impregnation, the resin matrix is in a form of slurry.", "The resin slurry is normally a liquid, mostly water, which is used to provide the fluidization for the reinforcing fibers.", "The resin is then deposited on or within a unidirectional reinforcing fiber assembly.", "The fiber mats wetted out by the slurry impregnation is required to pass through dewatering rolls.", "The fiber mats are finally dried out by heating.", "In the direct melt or film coating process, the resin matrix can be either deposited as a melted resin on the fiber web through a nip across the full width of the web, which is connected with an extruder or placed on both outer surfaces of the fiber web with a sheet layer of the resin, respectively.", "This process may be completed by using a melt-coating die, direction injection/film coating die, a pull through melt die, a coextrusion process, or the like.", "The assembly is then solidified under a high temperature (which is about 50° F. to about 120° F. higher than the melting point of the resin as aforementioned) and a high pressure to form a solid laminate.", "In order to overcome the limitations of direct melt impregnation, solution impregnation can be applied to avoid the high viscosity of the thermoplastic resin melts.", "Since the resin is dissolved in special solvents, viscosities of the solutions made of the resins are almost the same as those of thermoset resins.", "Hence, the fiber filaments are effectively wetted out by the resin with better penetration compared with those in the previous processes, but the solvents used for solution impregnation are usually very expensive.", "In some embodiments, the consolidating conditions for the underlay 24 generally vary with the thermoplastic species.", "For example, the consolidating temperature for a polyolefin matrix is about 400° F., while it can as high as about 527° F. However, the consolidating temperature of a PPS matrix should be about 600° F. The consolidating pressure is in a range between about 150 psi to about 250 psi.", "After the consolidating process, the laminate material is cooled down and slit into rolls with various widths.", "The width of FRTP laminates can be in a range between about 6 to about 13 inches, depending on the customer's requirements.", "In addition, these flexible FRTP laminates can be rolled up into coils which may have a linear length up to 1,500 ft. For most short fiber-filled FRTP sheet materials, there are about 1-8% voids or cavities in sheet depending on the performing and fabricating processes used.", "Even at a fiber ratio of about 60%, commingled fiber preforms and powder impregnated preforms usually have more voids in the resin/matrix structure than consolidated tape materials.", "For example, GComp has many voids in structure, meaning that liquid water or water vapor can easily penetrate through the voids at a standard atmosphere pressure.", "Hence, GComp cannot be directly used as a laminate underneath a trailer floor.", "In order to overcome this defect, an extra PP sheet can be laid down on the outer surface of the reinforced assembly during the consolidation step.", "The sealed GComp can meet the water impermeability requirement for trailer or container flooring (e.g., underlay 24) such that the flooring should not leak under a water pressure up to 20 psi for a suitable underside protection.", "In comparison, Polystrand's reinforced PETG sheet materials are a sandwich laminate and have few voids in structure.", "They do not leak even at a water pressure of 60 psi.", "With these voids, however, a soft and rough bonding surface of the to FRTP with a PP, HDPE, or PVC matrix that is hard to bond may provide strong bonding with an adhesive such as hot melt PUR through mechanical interlocking or “glue nails” and, accordingly, such a bonding surface may have no need for sanding and other surface treatments as aforementioned.", "In some cases, the composite flooring described herein may be provided commercially as a floor kit.", "FIG.", "8, which is schematic in nature, provides a floor kit 400, in which a plurality of floor boards 410, each including an underlay 412, are stacked together along with instructions 414 (e.g., which may be stapled or otherwise secured to the floor boards 410 at one end of the floor kit 400) for their assembly and use in forming a floor for a truck trailer or a container.", "It can be appreciated that in practice, the form and/or shape of floor boards 410 can vary and may resemble other floor boards as disclosed herein.", "In some cases, the plurality of floor boards 410 may be bound together via straps or binders 416, although this is not required.", "In some cases, each of the floor boards 410 have a length of 16 feet or longer, or 45 to 53 feet, and are suitable for use in a truck trailer or container.", "In some cases, each of the underlay 412 includes a plurality of fibers disposed within a thermoplastic resin.", "In some instances, at least some of the underlays 412 have a thickness of about 0.1 inches or less and are designed to enhance the strength of the floor board 410 while simultaneously having a flexibility that permits the underlay 412 to flex with the floor board 410 substantially without separating from the floor board 410.In some cases, the underlay 412 is secured to a bottom surface of the floor board 410 by adhesion.", "In some instances, the fibers include fiberglass fibers and the underlay 412 includes about 30 to 70 percent by weight of fiberglass.", "In some cases, the underlay 412 has a flexural strength of about 140,000 psi or less along a length of the floor board 410 and a flexural strength of about 60,000 psi or less along a width of the floor board 410.In some cases, the underlay 412 has a dyne level of 35 or more dyne/cm in surface energy.", "In some embodiments, the plurality of fibers are arranged in a plurality of layers including a first layer where a first portion of the plurality of fibers are substantially aligned along a length of the floor board 410 and a second layer where a second portion of the plurality of fibers are substantially aligned across a width of the floor board.", "Sometimes, the plurality of layers includes a third layer where a third portion of the plurality of fibers are substantially aligned along the length of the floor board 410.In some cases, each of the floor boards 410 has a strength in a three point bending test that fails at a flexural load of about 2,000 to 12,000 pounds of force, or about 6,000 to 10,000 pounds of force, or about 6,000 to 8,000 pounds of force.", "It will be appreciated that the load at failure will vary along in accordance with the thickness of the floor boards 410.Table One provides illustrative data, comparing a wood floor board with a fiberglass-reinforced PETG underlay that is made in accordance with the disclosure with a standard oak floor board.", "TABLE ONE Floorboard Load at failure (lbs) Strength increase thickness (inch) inventive floor standard oak rate (%) 1.000 2750 2350 17.0 1.125 4800 3600 33.3 1.188 5800* 4250* 36.5 1.250 6650 4800 38.5 1.313 7500* 5300* 41.5 1.375 8400* 5800* 44.8 1.500 9850 6800 44.9 *Denotes production data obtained from production samples.", "Other values represent estimates obtained from extrapolating from and/or interpolating between production data values.", "The wood substrate of the above composites was a laminated oak floorboard in which the wood strips had a width of about 0.935 or about 1.17 inches.", "All reinforced and unreinforced floor board samples had a width of about 11.938 inches and a length of about 3 feet.", "Before a three-point bending test, all test samples were placed at room conditions for 72 hrs.", "The flexural span was set to be 30 inches in accordance with the Fruehauf industry standard.", "During the bending test, the crosshead speed was controlled to be about 0.5 inch/min.", "At an equivalent reinforcing fiber ratio, an FRTP laminate is cheaper in price than FRTSP laminate because a thermoplastic resin is usually lower in cost than a thermoset.", "For instance, the price of PET, PETG and PP is in a range of between about $1.00 to $1.10 per pound in the current market, while a thermoset epoxy resin costs about $2.86 per pound.", "At the thickness of 0.030 inches, FRTP laminate with 40% PETG or PET and that with 50% PP are estimated to be about $0.70 and $0.55 per square foot (sq ft), respectively.", "However, the cost of 0.050 inch-thick FRSTP laminates with about 25% to 30% epoxy is in a range of between about $1.50 to $2.00/sq ft. By estimation, hence, composite flooring with FRTP laminates can save by about 50% to 65% in cost compared with that with FRTSP laminates at the same floorboard thickness.", "EXAMPLES The disclosure may be further clarified by reference to the following Examples, which are intended to illustrate but not limit the disclosure in any fashion.", "Example 1 A suitable FRTP laminate may include 40-70 percent by weight, or 60 percent by weight, of fiberglass.", "The FRTP laminate includes a three layer structure with over 60 percent of the fiberglass fibers oriented in a longitudinal direction.", "The FRTP laminate includes PET, PETG, nylon, or other thermoplastic resins.", "The fiberglass fibers in the top and bottom layers are continuous fibers that are oriented longitudinally, while the fibers in the intermediate layer are perpendicular to the fibers in the adjacent layers.", "The FRTP has a nominal width of 6-14 inches, or 12 inches, a nominal thickness of 0.025 to 0.045 inches, or 0.015 to 0.040 inches, or 0.030 inches, and a nominal unit weight of between about 0.2 to 0.3 lbs/ft2, or about 0.25 lbs/ft2.The FRTP has a longitudinal flexural strength of between about 100,000 and 110,000 psi and a longitudinal flexural modulus of between about 4.5 to 6 Msi.", "Both surfaces of FRTP are smooth and flat, which have a dyne level in a range between about 40 dyne/cm to about 50 dyne/cm in surface energy.", "The FRTP sheet is bonded to the wood via a hot melt PUR.", "Example 2 Another suitable FRTP laminate may include 15-30 percent, or 25 percent of fiberglass.", "The FRTP laminate includes a single layer structure with a continuous textile fiberglass mat.", "The FRTP laminate includes PP, HDPE, PVC or other thermoplastic resins.", "The FRTP has a nominal width of 6-14 inches, or 12 inches, a nominal thickness of between about 0.030 to 0.090 inches, or about 0.040 to 0.070 inches, or 0.050 inches, and a nominal unit weight in a range between about 0.20 to 0.50 lbs/ft2.The FRTP has a tensile strength of between about 30,000 to 35,000 psi and a tensile modulus of about 1.5 Msi.", "The FRTP sheet is bonded to the wood via hot melt PUR.", "The bonding surface of this FRTP material is rough and has many voids, which may provide strong interfacial bonding with hot melt PUR.", "Example 3 Another option of FRTP laminate may include 30-60 percent, or 50 percent, of fiberglass.", "The FRTP laminate includes a single layer structure with discontinuous glass fibers.", "The length of discontinuous fibers is in a range of between about 0.125 to 4 inches.", "The FRTP laminate includes PP, HDPE, PVC or other thermoplastic resins.", "The fiberglass fibers are randomly distributed in the FRTP laminate.", "The FRTP has a nominal width of 6-14 inches, or 12 inches, a nominal thickness of between about 0.020 to 0.050 inches, or about 0.025 to 0.045 inches, or about 0.030 inches, and a nominal unit weight of between about 0.24 to 0.30 lbs/ft2.The FRTP has a tensile strength of 8,000 to 15,000 psi and a tensile modulus of between about 1.0 to 2.0 Msi.", "The FRTP sheet is bonded to the wood via hot melt PUR.", "Similarly to Example 2, the bonding surface of this FRTP material is soft and rough.", "In addition, it has many voids, which may provide strong interfacial bonding with hot melt PUR.", "Example 4 In Table 2, the first to the fourth groups are composite wood floors reinforced with E-glass fiber, while the fifth group is a composite wood floor without E-glass reinforcement.", "The sixth and seventh groups are conventional wood flooring used as controls, whose mechanical properties are based on average values by production, respectively.", "In addition, the first to the third groups and the fifth group are composite flooring with a thermoplastic-based laminate, while Group No.", "4 is a composite floor with a thermoset-based laminate.", "Among the first to the fourth groups, the third group is a composite wood floor containing chopped E-glass fiber, whereas the rest are composite wood floors containing continuous E-glass fiber.", "The E-glass fiber ratio for the first to the fourth groups is about 60%, 60%, 50%, and 85%, respectively.", "The reinforced PETG laminates in the first and second groups have a longitudinal flexural strength in a range between about 110,000 psi to about 120,000 psi, respectively, while the reinforced PP laminates in Group No.", "3 have a longitudinal flexural strength of about 10,000 psi.", "TABLE TWO Strength Nominal increase FRP board Load at Deflection compared Sample Board FRP thickness thickness failure at failure to wood group quantity type (inch) (inch) (lbf) (inch) (%) 1 6 E-glass 0.025 1.188 6102 1.971 41.9 filled PETG 2 3 E-glass 0.030 1.313 6900 1.940 35.3 filled PETG 3 4 E-glass 0.040 1.313 5749 1.592 13.6 filled PP 4 6 E-glass 0.050 1.313 10626 3.587 108.4 filled epoxy 5 4 PP 0.035 1.188 4157 1.670 −3.3 without filler 6 — control — 1.313 5100 1.050 — 7 — control — 1.188 4300 1.200 — For this Example, the tested composite wood floorboards had a dimension of 3 ft by 1 ft and were placed at room temperature for 72 hours prior to the flexural test.", "In accordance with the Fruehauf industry standard, a three-point bending test was conducted for all sample boards by a universal test machine.", "The flexural span for each floorboard sample was set to be 30 inches.", "During the test, the crosshead speed was set to be about 0.5 inches/min.", "Table 2 shows the flexural properties of composite wood floorboards with different plastic laminates.", "For epoxy-based FRTSP laminates, the load at failure of the 1.313 inches thick composite floorboard was as high as 10,626 lbf and about 108% higher than that of conventional standard oak at the same board thickness.", "For thermoplastic based FRTP laminates, the load at failure of 1.313 inches composite floorboards with E-glass filled PETG and with E-glass filled PP had a maximum flexural load of 6,900 lbf and 5,749 lbf, respectively, which had a strength increase rate of 35.3% and 13.6%, respectively, compared with the unreinforced wood flooring at the same board thickness.", "For 1.188 inches composite wood floorboards with E-glass filled PETG, the load at failure was as high as 6,102 lbf, which was about 42% higher than that of conventional wood floorboards without filler at the same board thickness.", "Therefore, 1.188 inches E-glass reinforced composite floorboards were much stronger than conventional wood floorboards and the composite floorboards without filler at the same board thickness.", "In contrast, 1.188 inches composite floorboards without filler which use a 0.040 inch PP laminate were about 3% lower in bending strength than the conventional wood flooring at the same board thickness (Table 2).", "As can be seen, fiber shape and ratio of FRP laminates play a very important role in improving mechanical performance of composite wood flooring.", "For example, the higher the fiber ratio in FRP is, the higher the flexural strength of the resultant composites.", "According to Table 2, 1.313 inches wood composites reinforced with E-glass/epoxy laminates were much higher in flexural strength than those reinforced with E-glass/PETG and with E-glass/PP, respectively, at the same board thickness because the former used a higher fiber ratio and a thicker laminate than the latter two.", "At a close fiber ratio, however, the flexural strength of 1.313 inches composite wood floorboards reinforced with E-glass/PP laminates were only about 83% of that of composites reinforced with E-glass/PETG laminates even though the former also used a thicker FRP laminate.", "This may be attributed to the fact that the former used discontinuous fibers, while the latter used continuous fibers.", "Table 2 also indicates that the fiber type has a significant impact on the mechanical performance of FRP-reinforced composite wood flooring.", "Within the same PETG matrix, the first group had a higher strength increase rate than the second group compared with the corresponding unreinforced wood flooring, respectively, although the former has a thinner FRTP laminate and a thinner wood substrate than the latter.", "The strength difference between these two groups may be due to the fact that a stronger fiberglass was used in the first group.", "The fiber in the first group is about 20% stronger than that in the second group.", "The plastic matrix type may also influence the reinforcing effect of FRP on a wood substrate.", "As shown in Table 2, a thermoset epoxy matrix has better adhesion with a fiber than a thermoplastic PETG or PP matrix because the former has better wetting out of the fiber than the latter and can penetrate into the fiber.", "As aforementioned, the viscosity of PETG and PP matrices at their melting temperature is at least ten times higher than that of epoxy at room temperature.", "Hence, it is very difficult for PETG to completely wet out the fiberglass within a short processing time.", "Moreover, epoxy can provide a strong chemical bonding at the fiber-matrix interface, while PETG and PP only has a mechanical link with the fiber at the interface.", "It is shown that the E-glass reinforced composite floorboards are not only higher in flexural strength than conventional wood floorboards, but they are also more flexible than the conventional ones (Table 2) as indicated by relative deflection.", "Although the floorboards sealed with polypropylene laminates do not improve the flexural strength, they are also more flexible than conventional ones.", "Hence, the strength and stiffness properties of composite flooring with an FRTP laminate are between those of composite flooring with FRTSP and conventional oak flooring.", "Example 5 FIG.", "9 summarizes the relationship between the flexural strength of an FRP laminate at different thicknesses and structures and the strength increase rate of FRP-reinforced wood flooring over conventional wood flooring.", "FRTP underlay usually has a lower reinforcing performance than FRTSP underlay.", "That is, composite floorboards with an FRTP laminate have a lower flexural strength than those with an FRTSP laminate.", "As aforementioned, it usually takes longer time to manufacture thick FRTP materials.", "Accordingly, thin FRTP is normally used for lamination in order to balance its production yield and reinforcing performance.", "In this example, the thickness of FRTSP used was about 0.050 inches, while FRTP was about 0.030 inches in thickness.", "FIG.", "9 also shows that the slope of the strength increase for the FRTSP-reinforced flooring (e.g., the strength increase rate) was relatively steep, while the slope of the strength increase for the FRTP-reinforced flooring (e.g., the strength increase rate) was relatively flat.", "For 0.050 inch thick FRTSP laminates, the flexural strength of the resultant 1.313 inch composite flooring was increased by a rate ranging between about 60% to about 110% compared to conventional wood flooring at the same board thickness when the longitudinal flexural strength of FRTSP laminates was between about 50,000 psi to about 130,000 psi.", "Moreover, the higher the flexural strength of an FRTSP laminate, the higher the strength increase rate.", "For 0.030 inch FRTP laminates, however, the flexural strength of the resultant 1.188 inch thick composite flooring was increased by a lower rate which was in a range between about 10% to about 50% compared with conventional wood flooring at the same board thickness when the flexural strength of FRTP laminates was in a range between about 1,000 psi to about 130,000 psi (FIG.", "9).", "Even with the same flexural strength, an FRTSP laminate had a higher strength increase over conventional wood flooring than an FRTP laminate.", "For example, the flexural strength of wood flooring reinforced with 0.050 inch FRTSP was increased by about 90% compared with that of conventional wood flooring when the FRTSP has a flexural strength of about 110,000 psi in the longitudinal direction.", "However, the flexural strength of wood flooring reinforced with 0.030 inch FRTP which has the same flexural strength was increased only by about 35% compared with that of conventional wood flooring (FIG.", "9).", "Hence, FRTP laminates had a lower impact on the increased strength of the resultant reinforced wood flooring than FRTSP laminates.", "In addition, the strength increase rate of FRTP reinforced wood flooring was about 40% to about 60% lower than that of FRTSP reinforced wood flooring at the same board thickness.", "Example 6 In order to evaluate the bonding durability of hot melt PUR at the interface between the FRTP thermoplastic and wood, a weathering resistance test for FRTP-reinforced wood flooring was developed with an accelerated laboratory environment.", "This weathering resistance test is very similar to the wet shear test required by the Fruehauf industry standard.", "For this example, all wood composite floorboard samples were submerged in water for 24 hours, at least one inch below the water surface and were then dried at 140° F. for 8 hrs.", "in a lab oven.", "After that, the composite samples were soaked again in water for 16 hrs at room temperature.", "Each procedure of 8 hr drying and 16 hr soaking was counted as one cycle for this test.", "The drying and soaking cycle was repeated until some defects or failure occurred on any one of the composite samples.", "For this example, three batches of FRTP- and FRTSP-reinforced floorboard samples were prepared and tested.", "Among them, the composite floorboard samples with FRTSP were made by one of the trailer flooring manufacturers in the market.", "The nominal thickness of FRTSP laminates bonded on the wood substrate was about 0.055 inches.", "The FRTSP laminate was white in color.", "All composite floorboard samples with FRTP were made by Industrial Hardwood Products, Inc.", "The FRTP materials were PETG-based laminates with a black color appearance.", "The nominal thickness of FRTP laminates was about 0.030 inches and all the composite floorboard samples had a nominal thickness of 1.188 inches.", "For each test sample, the top wood surface had no reinforcement, while the bottom surface was attached with FRP laminates.", "Before the experiment, the composite floorboard samples were placed at room conditions for 72 hrs.", "The composite floorboard samples were cut into different dimensions.", "In addition, the FRP overlays on the bottom surface were cut off to wood with different patterns of cut lines by a table saw.", "In the first batch, there were two composite floorboard samples with a dimension of 10 inches by 4.5 inches.", "On the bottom surface, each composite sample had two ⅛ inches longitudinal cut lines cut through the FRP laminate to wood.", "However, there were no cut lines on the top surface.", "For these two composite samples, one was a white FRTSP-reinforced oak floorboard, while another was a black FRTP-reinforced oak floorboard.", "Before the soaking-drying procedures, all ends of both composite samples were completely sealed with a water resistant wood coating.", "After the 13th cycle, the FRTSP-reinforced floorboard became warped, with deep cracks in most of the gluelines.", "A number of cracks were developed on the top surface, edges and ends, indicating that high stress might exist in the FRTSP composite sample due to the unbalance board structure of thick FRTSP sheet-reinforced composite flooring.", "After 13 cycles, the FRTP-reinforced floorboard was still flat and the FRTP sheet was intact.", "In addition, there were few cracks on all the wood surfaces.", "After passing the 23rd cycle, the FRTP composite sample started warping, but the FRTP sheet was still intact.", "The longitudinal cracks were developed along all gluelines on the top surface of the FRTSP composite sample and also seen at both ends.", "Even after the 23rd cycle, the FRTP reinforced floorboard had few visible cracks on edges, ends and top surfaces compared with the FRTSP-reinforced floorboard which was only passed 13 cycles.", "In the second batch, there were a total of four composite floorboard samples.", "Each sample had a dimension of 4.5 inches by 5.5 inches.", "One test sample was a white FRTSP-reinforced oak floorboard, while the others were a black FRTP-reinforced oak, ash, and maple floorboard, respectively.", "Each composite floorboard sample had two ⅛ inch wide by 1/16 inch deep longitudinal cut lines on the bottom surface and three ⅛ inch wide by 1/16 inch deep longitudinal cut lines on the top surface, respectively.", "After the 13th cycle, the FRSTP-reinforced oak floorboard was warping, but the FRTSP sheet was intact.", "Some cracks were seen along the gluelines and at both ends of the above floorboards.", "After 13 cycles, all the FRTP composite floorboards were flat.", "Moreover, the FRTP sheet was intact.", "For the FRTP composite ash floorboard, there were no visible cracks at the gluelines and at both ends.", "There were no cracks at the gluelines of the FRTP composite oak floorboard, but some tiny cracks existed at its both ends.", "For the FRTP composite maple floorboard, however, shallow cracks along most of the gluelines and at its both ends were clearly seen.", "Furthermore, the FRTP sheet on the maple substrate was wavy after the 13th cycle.", "This may indicate that maple species has relatively low dimensional stability when it encounters water compared with oak and ash species.", "In the third batch, there were a total of ten composite samples.", "Different from the samples in the first and second batches, the samples in the third batch had crisscross cutting on the FRP sheet at the bottom surface.", "The composite samples of the third batch were divided into two subgroups.", "The first subgroup included two white FRTSP-reinforced oak floorboards and two black FRTP-reinforced oak floorboards.", "All the composite samples were 7 inches by 6 inches in dimension.", "On the bottom surface, the crisscrossing cut lines formed a number of 1.25 inch by 1.25 inch FRP blocks.", "During the soaking and drying process, these crisscrossing cut lines provided high stress to debond the FRP sheet from wood under the accelerated test conditions.", "The second subgroup consisted of six composite samples with a dimension of 5 inches by 6 inches, including three white FRTSP-reinforced oak floorboards and three black FRTP reinforced oak ones.", "In both subgroups, FRP blocks with different dimensions on the bottom surface of each composite sample were formed by the crisscrossing cut lines.", "For example, the FRTSP blocks with crisscrossing cut lines were 1 inch by 1 inch, 1 inch by 1.25 inches, 1.5 inches by 2 inches in dimension for the FRTSP-reinforced oak floorboards in the first subgroup, while the FRTP blocks were 0.75 inches by 0.75 inches, 0.75 inches by 1.25 inches, and 1.25 inches by 2 inches in dimension for the FRTP reinforced oak floorboards in the second subgroup.", "In general, the smaller the FRP blocks, the higher the debonding stress at the FRP-wood interface.", "For the first subgroup, the top surface of all composite samples had three ⅛ inch wide and ⅛ inch deep longitudinal cut lines, which was used to reduce the debonding stress at the interface.", "However, only the FRTP reinforce oak floorboard which had 0.75 inch by 0.75 inch crisscross-cut lines on FRTP had three ⅛ inch wide by ⅛ inch deep longitudinal cut lines on the top surface.", "After 14 cycles, three 1.25 inch by 1.25 inch FRTSP blocks were popped off for one of the FRTSP reinforced oak floorboards in the first subgroup, which accounted for 21% of the whole FRTSP blocks.", "However, there was no popping off or delamination for both FRTP-reinforced floorboards after the 14th cycle.", "In addition, both FRTSP reinforced floorboards were warping and had serious cracks along the gluelines, but both FRTP-reinforced ones were still flat with few visible cracks at the gluelines on wood.", "In the second subgroup, the FRTSP-reinforced oak floorboard with 1 inch by 1 inch crisscrossing cut lines was delaminated at one glueline after the 5th cycle, while the FRTSP-reinforced floorboard with 1 inch by 1.5 inch crisscrossing cut lines had serious delamination at its three glue lines after it passed the 15th cycle.", "Although the FRTSP-reinforced floorboard with 1.5 inch by 2 inch crisscrossing cut lines passed 14 cycles, it was warping and had deep cracking along most gluelines.", "In contrast, none of the three FRTP-reinforced floorboards had any delamination at the gluelines and all were flat without visible cracks on wood.", "In addition, both of the FRTSP-reinforced floorboards without stress release line on the top surface had almost the same dimensional stability as that with three longitudinal cut lines which had 0.75 inch by 0.75 inch FRTP blocks on the bottom surface 23.Accordingly, the above weathering resistance tests indicate that FRTP-reinforced wood floorboards have the same bonding durability at the wood-FRP interface as FRTSP-reinforced wood floorboards.", "Moreover, the former has a better dimensional stability than the latter because the FRTP underlay is more flexible and thinner than the FRTSP underlay.", "It should be understood that this disclosure is, in many respects, only illustrative.", "Changes may be made in details, particularly in matters of shape, size, and arrangement of steps without exceeding the scope of the invention.", "The invention's scope is, of course, defined in the language in which the appended claims are expressed." ] ]
Patent_15874419
[ [ "IMAGE PROCESSING DEVICE, IMAGE PROCESSING METHOD AND RECORDING MEDIUM", "In the image processing device, the method and the recording medium according to the present invention, the characteristic information extractor extracts the number of times the same subject appears in the still images.", "The target object detector detects the target subject which appears the number of times not less than the threshold value.", "The image analysis condition determiner sets the image analysis condition for the portion of the moving image where the target subject is absent to be rougher than that where the target subject is present.", "The frame image analyzer extracts frame images from the moving image in accordance with the image analysis condition.", "The frame image output section calculates the evaluation value of the frame images based on the result of the image analysis and output the frame image having the evaluation value not less than the threshold value." ], [ "1.An image processing device comprising: an image acquiring section configured to acquire a moving image and a plurality of still images; a characteristic information extractor configured to extract characteristic information from the plurality of still images; an image analysis condition determiner configured to set an image analysis condition for one portion of the moving image to be rougher than an image analysis condition for another portion of the moving image based on the characteristic information; a frame image analyzer configured to extract frame images from the moving image and perform image analysis on the extracted frame images in accordance with the image analysis condition; and a frame image output section configured to calculate an evaluation value of each of the frame images based on a result of the image analysis and output, of the frame images, a frame image having an evaluation value not less than a first threshold value.", "2.The image processing device according to claim 1, wherein the image analysis condition is frequency of extracting frame images, and the image analysis condition determiner sets a frequency of extracting frame images from a portion of the moving image where a relevance score between the moving image and the plurality of still images is lower than a second threshold value, to be less than a frequency of extracting frame images from a portion of the moving image where the relevance score is not lower than the second threshold value.", "3.The image processing device according to claim 1, further comprising a target object detector configured to detect a target subject that is a subject to be a target object based on the characteristic information, wherein the characteristic information is a number of times a subject appears in the plurality of still images, the target object detector detects a subject that appears a number of times not less than a third threshold value, as a target subject, and the image analysis condition determiner sets a frequency of extracting frame images from a portion of the moving image where a target subject that appears a number of times less than the third threshold value is present, to be less than a frequency of extracting frame images from a portion of the moving image where a target subject that appears a number of times not less than the third threshold value is present.", "4.The image processing device according to claim 1, wherein the image analysis condition is a number of items of the image analysis, and the image analysis condition determiner sets a number of items of the image analysis performed on a frame image extracted from a portion of the moving image where a relevance score between the moving image and the plurality of still images is lower than a second threshold value, to be smaller than a number of items of the image analysis performed on a frame image extracted from a portion of the moving image where the relevance score is not lower than the second threshold value.", "5.The image processing device according to claim 4, further comprising a target object detector configured to detect a target subject that is a subject to be a target object based on the characteristic information, wherein the characteristic information is a number of times a subject appears in the plurality of still images, the target object detector detects a subject that appears a number of times not less than a third threshold value, as a target subject, and the image analysis condition determiner sets a number of items of the image analysis performed on a frame image extracted from a portion of the moving image where a target subject that appears a number of times less than the third threshold value is present, to be less than a number of items of the image analysis performed on a frame image extracted from a portion of the moving image where a target subject that appears a number of times not less than the third threshold value is present.", "6.The image processing device according to claim 3, wherein the subject is a person, an animal or an inanimate object, and the image analysis condition determiner changes the frequency of extracting frame images from the moving image depending on a type of the subject.", "7.The image processing device according to claim 6, wherein the image analysis condition determiner sets frequency of extracting frame images from a portion of the moving image where a person and an animal are absent, to be less than frequency of extracting frame images from a portion of the moving image where at least one of a person and an animal is present.", "8.The image processing device according to claim 6, wherein the image analysis condition determiner changes the frequency of extracting frame images from the moving image depending on a content of a frame image.", "9.The image processing device according to claim 8, wherein the image analysis condition determiner sets frequency of extracting frame images from a portion of the moving image where neither a person nor an animal appears in a size not less than a fourth threshold value, to be less than frequency of extracting frame images from a portion of the moving image where at least one of a person and an animal appears in a size not less than the fourth threshold value.", "10.The image processing device according to claim 2, wherein the characteristic information is a shooting time of each of the plurality of still images, and the image analysis condition determiner sets frequency of extracting frame images from a portion of the moving image which portion was shot within a shooting time range covering certain periods of time before and after a shooting time of each of the plurality of still images, to be less than frequency of extracting frame images from a portion of the moving image which portion was shot within a shooting time range other than the shooting time range covering certain periods of time before and after the shooting time of each of the plurality of still images.", "11.The image processing device according to claim 4, wherein the characteristic information is a shooting time of each of the plurality of still images, and the image analysis condition determiner sets a number of items of image analysis performed on a frame image extracted from a portion of the moving image which portion was shot within a shooting time range covering certain periods of time before and after a shooting time of each of the plurality of still images, to be smaller than a number of items of image analysis performed on a frame image extracted from a portion of the moving image which portion was shot within a shooting time range other than the shooting time range covering certain periods of time before and after the shooting time of each of the plurality of still images.", "12.The image processing device according to claim 10, wherein the image acquiring section acquires a plurality of the moving images, and the image analysis condition determiner sets the image analysis condition so as not to allow extraction of a frame image from, of the plurality of moving images, a moving image shot within the shooting time range including the shooting time of each of the plurality of still images.", "13.The image processing device according to claim 10, wherein the image analysis condition determiner sets the image analysis condition so as not to allow extraction of a frame image from a portion of the moving image which portion was shot within the shooting time range covering certain periods of time before and after the shooting time of each of the plurality of still images.", "14.The image processing device according to claim 1, wherein the frame image output section sets an evaluation value for a frame image having been shot in a same time range as a time range including a time that, of the plurality of still images, at least one still image was shot, to be lower than an evaluation value for a frame image having not been shot in the same time range.", "15.The image processing device according to claim 1, wherein the frame image output section sets an evaluation value for a frame image having been shot in a same time range as a time range including a time that, of the plurality of still images, at least one still image was shot and, moreover, at a same shooting time as that of the still image, to be lower than an evaluation value for a frame image having not been shot in the same time range and at the same shooting time.", "16.The image processing device according to claim 1, wherein the characteristic information is information on a result of person recognition for each of the plurality of still images, and the image analysis condition determiner sets the image analysis condition in such a manner to allow extraction of a frame image showing a person corresponding to the information on the result of person recognition, from the moving image.", "17.The image processing device according to claim 1, wherein the characteristic information is information on a result of scene determination or object recognition for each of the plurality of still images, and the image analysis condition determiner sets the image analysis condition in such a manner to allow extraction of a frame image showing a scene corresponding to the information on the result of scene determination or a frame image showing an object corresponding to the information on the result of object recognition, from the moving image.", "18.The image processing device according to claim 1, wherein the characteristic information is information on person's movement in each of the plurality of still images, and the image analysis condition determiner sets the image analysis condition in such a manner to allow extraction of a frame image in which a person exhibiting movement corresponding to the information on person's movement is present, from the moving image.", "19.An image processing method comprising: acquiring a moving image and a plurality of still images, with an image acquiring section; extracting characteristic information from the plurality of still images, with a characteristic information extractor; setting an image analysis condition for one portion of the moving image to be rougher than an image analysis condition for another portion of the moving image based on the characteristic information, with an image analysis condition determiner; extracting frame images from the moving image and performing image analysis on the extracted frame images in accordance with the image analysis condition, with a frame image analyzer; and calculating an evaluation value of each of the frame images based on a result of the image analysis and outputting, of the frame images, a frame image having an evaluation value not less than a first threshold value, with a frame image output section.", "20.A non-transitory computer readable recording medium having recorded thereon a program for causing a computer to execute each step of the image processing method according to claim 19." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>The present invention relates to an image processing device, an image processing method and a recording medium for extracting a frame image corresponding to a best shot from a moving image and outputting the frame image.", "In recent years, many moving images are shot even by common families.", "A shot moving image may include a best shot showing a scene that is hard to seize by a device for taking still images (such as a shot properly showing a motion of a person shot for the moving image), for instance, the scene of a child blowing out candles on his/her birthday.", "On the other hand, moving images may include scenes with less movement of persons, low importance, poor composition, poor image quality, or other unfavorable properties.", "It is therefore extremely troublesome to find a best shot in a moving image and extract a frame image corresponding to the best shot from the moving image.", "Meanwhile, there has been used a school photography service that sends a photographer to a school to take still images of school events such as a sports day.", "In this service, shot still images are uploaded to a network so that parents can order photographic prints of the still images via the network.", "In this service, by, for example, in addition to taking still images, shooting moving images with fixed cameras or the like and extracting frame images corresponding to best shots from the moving images, it is possible to order photographic prints of the frame images as with still images.", "In this case, there is a demand for extracting frame images corresponding to best shots from moving images with taking account of information on still images, for example, preferentially extracting frame images that show scenes still images do not show, from moving images.", "Aside from that, when, for instance, only two brothers are shot as subjects for a moving image of a family, it is only necessary to track the two brothers in the shot moving image.", "However, in a moving image of a sports day, several tens of persons appear one after another.", "In this case, simply tracking all the persons in the moving image results in longer processing time, and tracking unrelated persons results in lower accuracy of extraction of frame images.", "To cope with it, there is a demand for properly extracting a frame image corresponding to a best shot even from a moving image showing many persons.", "Aside from that, when a moving image is shot by a fixed camera or the like, the shooting period of time is to be long and this is disadvantageous in terms of processing time.", "To cope with it, there is a demand for extracting only necessary frame images from a moving image as efficiently and quickly as possible.", "Now JP 2008-294513 A, JP 2010-93405 A and JP 2012-44646 A are mentioned as literatures related to the present invention.", "JP 2008-294513 A relates to a video playback device for playing back a highlight scene of a moving image content.", "The literature describes that time information on a still image content which was taken simultaneously with shooting a moving image content is used in detecting a highlight scene of the moving image content.", "JP 2010-93405 A relates to an information processor and the like for playing back a highlight scene of a moving image content.", "The literature describes that, based on the number of still image shooting devices that shot a highlight scene detection desired portion in a highlight scene of a moving image content, the importance of the highlight scene is controlled.", "JP 2012-44646 A relates to an image processing device and the like for making a layout of a plurality of images.", "The literature describes extracting frame images from a moving image in accordance with the relationship between the moving image and still images and determining a layout of the still images and the frame images." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>While JP 2012-44646 A describes extracting frame images from a moving image in accordance with the relationship between the moving image and still images as described above, none of JP 2008-294513 A, JP 2010-93405 A and JP 2012-44646 A mentions a method of extracting a frame image corresponding to a best shot from a moving image accurately, efficiently and rapidly.", "An object of the present invention is to solve the problem of the related art and provide an image processing device, an image processing method and a recording medium that make it possible to extract a frame image corresponding to a best shot from a moving image accurately, efficiently and rapidly.", "In order to achieve the above object, the present invention provides an image processing device including: an image acquiring section configured to acquire a moving image and a plurality of still images; a characteristic information extractor configured to extract, from the plurality of still images, at least a number of times a same subject appears in the plurality of still images, as characteristic information; a target object detector configured to detect a subject which appears a number of times not less than a first threshold value, as a target subject; an image analysis condition determiner configured to set an image analysis condition for a portion of the moving image where the target subject is absent to be rougher than the image analysis condition for a portion of the moving image where the target subject is present; a frame image analyzer configured to extract frame images from the moving image and perform image analysis on the extracted frame images in accordance with the image analysis condition; and a frame image output section configured to calculate an evaluation value of each of the frame images based on a result of the image analysis and output, of the frame images, a frame image having an evaluation value not less than a second threshold value.", "Also, the present invention provides an image processing method including: a step of acquiring a moving image and a plurality of still images, with an image acquiring section; a step of extracting, from the plurality of still images, at least a number of times a same subject appears in the plurality of still images, as characteristic information, with a characteristic information extractor; a step of detecting a subject which appears a number of times not less than a first threshold value, as a target subject, with a target object detector; a step of setting an image analysis condition for a portion of the moving image where the target subject is absent to be rougher than the image analysis condition for a portion of the moving image where the target subject is present, with an image analysis condition determiner; a step of extracting frame images from the moving image and performing image analysis on the extracted frame images in accordance with the image analysis condition, with a frame image analyzer; and a step of calculating an evaluation value of each of the frame images based on a result of the image analysis and outputting, of the frame images, a frame image having an evaluation value not less than a second threshold value, with a frame image output section.", "Also, the present invention provides a non-transitory computer readable recording medium having recorded thereon a program for causing a computer to execute each step of the image processing method according to above.", "In the present invention, characteristic information is extracted from a plurality of still images; based on the characteristic information, an image analysis condition for a portion of a moving image which portion has low relevance with the still images is set to be rougher than that for a portion of the moving image which portion has high relevance with the still images; and frame images are extracted from the moving image and analyzed.", "According to the present invention, it is possible to extract a frame image corresponding to a best shot from a moving image accurately, efficiently and rapidly." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS The present application is a Divisional of U.S. application Ser.", "No.", "15/150,452 filed May 10, 2016, and claims priority under 35 U.S.C.", "§ 119 to Japanese Patent Application No.", "2015-107009 filed May 27, 2015.The above application is hereby expressly incorporated by reference, in its entirety, into the present application.", "BACKGROUND OF THE INVENTION The present invention relates to an image processing device, an image processing method and a recording medium for extracting a frame image corresponding to a best shot from a moving image and outputting the frame image.", "In recent years, many moving images are shot even by common families.", "A shot moving image may include a best shot showing a scene that is hard to seize by a device for taking still images (such as a shot properly showing a motion of a person shot for the moving image), for instance, the scene of a child blowing out candles on his/her birthday.", "On the other hand, moving images may include scenes with less movement of persons, low importance, poor composition, poor image quality, or other unfavorable properties.", "It is therefore extremely troublesome to find a best shot in a moving image and extract a frame image corresponding to the best shot from the moving image.", "Meanwhile, there has been used a school photography service that sends a photographer to a school to take still images of school events such as a sports day.", "In this service, shot still images are uploaded to a network so that parents can order photographic prints of the still images via the network.", "In this service, by, for example, in addition to taking still images, shooting moving images with fixed cameras or the like and extracting frame images corresponding to best shots from the moving images, it is possible to order photographic prints of the frame images as with still images.", "In this case, there is a demand for extracting frame images corresponding to best shots from moving images with taking account of information on still images, for example, preferentially extracting frame images that show scenes still images do not show, from moving images.", "Aside from that, when, for instance, only two brothers are shot as subjects for a moving image of a family, it is only necessary to track the two brothers in the shot moving image.", "However, in a moving image of a sports day, several tens of persons appear one after another.", "In this case, simply tracking all the persons in the moving image results in longer processing time, and tracking unrelated persons results in lower accuracy of extraction of frame images.", "To cope with it, there is a demand for properly extracting a frame image corresponding to a best shot even from a moving image showing many persons.", "Aside from that, when a moving image is shot by a fixed camera or the like, the shooting period of time is to be long and this is disadvantageous in terms of processing time.", "To cope with it, there is a demand for extracting only necessary frame images from a moving image as efficiently and quickly as possible.", "Now JP 2008-294513 A, JP 2010-93405 A and JP 2012-44646 A are mentioned as literatures related to the present invention.", "JP 2008-294513 A relates to a video playback device for playing back a highlight scene of a moving image content.", "The literature describes that time information on a still image content which was taken simultaneously with shooting a moving image content is used in detecting a highlight scene of the moving image content.", "JP 2010-93405 A relates to an information processor and the like for playing back a highlight scene of a moving image content.", "The literature describes that, based on the number of still image shooting devices that shot a highlight scene detection desired portion in a highlight scene of a moving image content, the importance of the highlight scene is controlled.", "JP 2012-44646 A relates to an image processing device and the like for making a layout of a plurality of images.", "The literature describes extracting frame images from a moving image in accordance with the relationship between the moving image and still images and determining a layout of the still images and the frame images.", "SUMMARY OF THE INVENTION While JP 2012-44646 A describes extracting frame images from a moving image in accordance with the relationship between the moving image and still images as described above, none of JP 2008-294513 A, JP 2010-93405 A and JP 2012-44646 A mentions a method of extracting a frame image corresponding to a best shot from a moving image accurately, efficiently and rapidly.", "An object of the present invention is to solve the problem of the related art and provide an image processing device, an image processing method and a recording medium that make it possible to extract a frame image corresponding to a best shot from a moving image accurately, efficiently and rapidly.", "In order to achieve the above object, the present invention provides an image processing device including: an image acquiring section configured to acquire a moving image and a plurality of still images; a characteristic information extractor configured to extract, from the plurality of still images, at least a number of times a same subject appears in the plurality of still images, as characteristic information; a target object detector configured to detect a subject which appears a number of times not less than a first threshold value, as a target subject; an image analysis condition determiner configured to set an image analysis condition for a portion of the moving image where the target subject is absent to be rougher than the image analysis condition for a portion of the moving image where the target subject is present; a frame image analyzer configured to extract frame images from the moving image and perform image analysis on the extracted frame images in accordance with the image analysis condition; and a frame image output section configured to calculate an evaluation value of each of the frame images based on a result of the image analysis and output, of the frame images, a frame image having an evaluation value not less than a second threshold value.", "Also, the present invention provides an image processing method including: a step of acquiring a moving image and a plurality of still images, with an image acquiring section; a step of extracting, from the plurality of still images, at least a number of times a same subject appears in the plurality of still images, as characteristic information, with a characteristic information extractor; a step of detecting a subject which appears a number of times not less than a first threshold value, as a target subject, with a target object detector; a step of setting an image analysis condition for a portion of the moving image where the target subject is absent to be rougher than the image analysis condition for a portion of the moving image where the target subject is present, with an image analysis condition determiner; a step of extracting frame images from the moving image and performing image analysis on the extracted frame images in accordance with the image analysis condition, with a frame image analyzer; and a step of calculating an evaluation value of each of the frame images based on a result of the image analysis and outputting, of the frame images, a frame image having an evaluation value not less than a second threshold value, with a frame image output section.", "Also, the present invention provides a non-transitory computer readable recording medium having recorded thereon a program for causing a computer to execute each step of the image processing method according to above.", "In the present invention, characteristic information is extracted from a plurality of still images; based on the characteristic information, an image analysis condition for a portion of a moving image which portion has low relevance with the still images is set to be rougher than that for a portion of the moving image which portion has high relevance with the still images; and frame images are extracted from the moving image and analyzed.", "According to the present invention, it is possible to extract a frame image corresponding to a best shot from a moving image accurately, efficiently and rapidly.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a block diagram showing an embodiment of the configuration of an image processing device of the invention.", "FIG.", "2 is a block diagram showing an embodiment of the configuration of a frame image analyzer shown in FIG.", "1.FIGS.", "3A, 3B and 3C include, to the left, conceptual diagrams each showing an exemplary movement trajectory of a person of interest and, to the right, conceptual diagrams each showing an exemplary action history image of the person of interest.", "FIG.", "4 is a flowchart showing an example of the operation of the image processing device.", "FIG.", "5 is a flowchart showing an example of the operation of the frame image analyzer.", "FIG.", "6A is a conceptual diagram showing an exemplary method of extracting frame images from a moving image by means of a conventional image processing device; and FIG.", "6B is a conceptual diagram showing an exemplary method of extracting frame images from a moving image by means of the image processing device of the invention.", "DETAILED DESCRIPTION OF THE INVENTION An image processing device, an image processing method and a recording medium of the present invention are described below in detail with reference to preferred embodiments shown in the accompanying drawings.", "FIG.", "1 is a block diagram showing an embodiment of the configuration of an image processing device of the invention.", "An image processing device 10 shown in FIG.", "1 extracts a frame image corresponding to a best shot from a moving image based on a plurality of still images and outputs the frame image.", "The image processing device 10 includes an image acquiring section 12, a characteristic information extractor 14, a target object detector 16, an image analysis condition determiner 18, a frame image analyzer 20 and a frame image output section 22.The image acquiring section 12 acquires a moving image (moving image data) and a plurality of still images (still image data) to be subjected to the processing.", "A moving image and a plurality of still images acquired together with the moving image are, for instance, ones showing the same school event as obtained through a school photography service.", "Such a moving image and still images are not limited to ones obtained through a school photography service and may be ones showing the same event or ones showing the same subject.", "The characteristic information extractor 14 extracts, from a plurality of still images acquired by the image acquiring section 12, characteristic information representing the relevance with a moving image acquired together with the still images.", "The characteristic information is not limited as long as it represents the relevance between a moving image and still images, and one example thereof is information on the number of times the same subject appears in a plurality of still images.", "The target object detector 16 detects a target subject that is a subject to be a target object based on characteristic information extracted by the characteristic information extractor 14.When the characteristic information is the number of times the same subject appears in a plurality of still images, the target object detector 16 detects a subject that appears many times (i.e., the number of times not less than a threshold value) as a target subject.", "The term “subject” used herein refers to, in addition to a person, any of animals (e.g., dogs and cats), objects (e.g., dishes, flowers, Bonsai trees, rings and accessories) and scenes (e.g., a certain time range in which the same background is seen in a moving image, such as a night view, an evening view, an ocean view or a forest view, and a time range including the time at which an event, such as a relay race or a beanbag toss game in a sports day, was shot).", "The image analysis condition determiner 18 sets an image analysis condition for a portion (non-important time range) of a moving image which portion has low relevance with a plurality of still images (i.e., has a relevance score lower than a threshold value) to be rougher than that for a portion (important time range) of the moving image which portion has high relevance with the still images (i.e., has a relevance score not lower than the threshold value) based on characteristic information extracted by the characteristic information extractor 14.The image analysis condition determiner 18 also changes the image analysis condition depending on whether a subject is a target subject detected by the target object detector 16.When the characteristic information is the number of times the same subject appears in a plurality of still images, the image analysis condition determiner 18 sets an image analysis condition for a portion of a moving image where a target subject, which appears many times (i.e., the number of times not less than a threshold value), is absent to be rougher than that for a portion of the moving image where the target subject is present.", "The image analysis condition is not limited as long as it is a condition applied in analyzing a moving image, namely frame images, and examples thereof include the frequency of extracting frame images from a moving image, the number of items of image analysis performed on a frame image, and the image size of a frame image in image analysis.", "A rough image analysis condition refers to a poorer (worse) condition compared to a dense image analysis condition, and examples thereof include such conditions as a reduced frequency of extracting frame images, a reduced number of items of image analysis performed on a frame image, and a reduced image size of a frame image in image analysis.", "When the image analysis condition is the frequency of extracting frame images from a moving image, the image analysis condition determiner 18 sets the frequency of extracting frame images from a portion of a moving image where a target subject is absent to be less than that of extracting frame images from a portion of the moving image where the target subject is present.", "When the image analysis condition is the number of items of image analysis performed on a frame image, the image analysis condition determiner 18 sets the number of items of image analysis performed on a frame image extracted from a portion of a moving image where a target subject is absent to be smaller than that of items of image analysis performed on frame images extracted from a portion of the moving image where the target subject is present.", "For example, the number of items of image analysis performed on a frame image extracted from a portion of a moving image where a target subject is present is set to be two or more from among person detection, person's motion analysis, detection of a period of time during which a person is continuously present in a moving image, composition analysis, and image quality determination, the two or more including at least the person detection.", "On the other hand, the number of items of image analysis performed on a frame image extracted from a portion of a moving image where a target subject is absent is set to, while including the person detection, be smaller than the number of items of image analysis performed on a frame image extracted from a portion of the moving image where the target subject is present.", "When the image analysis condition is the image size of a frame image in image analysis, the image analysis condition determiner 18 sets the image size, in image analysis, of a frame image extracted from a portion of a moving image where a target subject is absent to be smaller than the image size, in image analysis, of a frame image extracted from a portion of the moving image where the target subject is present.", "For example, when the image size of a frame image extracted from a moving image is 800×600 pixels, the image size, in image analysis, of a frame image extracted from a portion of the moving image where a target subject is present is set to 800×600 pixels (no scale-down), whereas the image size, in image analysis, of a frame image extracted from a portion of the moving image where the target subject is absent is reduced to 400×300 pixels.", "For a frame image extracted from a portion of a moving image where a target subject is absent, it is only necessary to check whether the target subject is present and therefore, no problem arises even if the image size of the frame image in image analysis is reduced.", "The image analysis condition determiner 18 can set one or simultaneously set two or more out of image analysis conditions including the frequency of extracting frame images, the number of items of image analysis, and the image size of a frame image in image analysis.", "The frame image analyzer 20 extracts frame images from a moving image and performs the image analysis on the extracted frame images in accordance with an image analysis condition(s) determined by the image analysis condition determiner 18.For instance, the frame image analyzer 20 extracts frame images from a moving image with the frequency of extraction in accordance with a determined image analysis condition, reduces the image size of frame images in accordance with a determined image analysis condition, and performs the image analysis by the number of items in accordance with a determined image analysis condition.", "The frame image analyzer 20 will be detailed later.", "The frame image output section 22 calculates an evaluation value of each frame image extracted from a moving image based on a result of image analysis made by the frame image analyzer 20 and outputs, of a plurality of frame images extracted from the moving image, at least one frame image having a high evaluation value (i.e., an evaluation value not lower than a threshold value) as a frame image corresponding to a best shot.", "Next, the frame image analyzer 20 is described in detail.", "FIG.", "2 is a block diagram showing an embodiment of the configuration of the frame image analyzer shown in FIG.", "1.The frame image analyzer 20 shown in FIG.", "2 illustrates one exemplary configuration in the case where a frame image is output in which a target subject (e.g., target person) detected by the target object detector 16 is present.", "The frame image analyzer 20 includes a frame image extractor 24, a person-of-interest detector 26, a movement trajectory detector 28, a motion analyzer 30, an importance determiner 32, a composition analyzer 34 and an image quality determiner 36.The frame image extractor 24 extracts a plurality of frame images from a moving image acquired by the image acquiring section 12 in accordance with an image analysis condition(s) determined by the image analysis condition determiner 18.In the case of applying a dense image analysis condition, the frame image extractor 24 extracts, for instance, frame images of all frames of a moving image.", "The present invention is, however, not limited to this example, and the frame image extractor 24 may extract one frame image every predetermined number of frames, e.g., two frames.", "Alternatively, the frame image extractor 24 may extract frame images only from a given range of a moving image.", "In the case of applying a rough image analysis condition, the frame image extractor 24 extracts frame images from a moving image with less frequency of extraction compared to the case of applying a dense image analysis condition.", "The person-of-interest detector 26 detects, in a plurality of frame images extracted from a moving image by the frame image extractor 24, a person identical or resembling a target person detected by the target object detector 16, as a person of interest.", "For instance, the person-of-interest detector 26 detects whether a person is present in each frame image and compares an image of a detected person with an image of a target person detected by the target object detector 16 (e.g., compares face images) to thereby identify, from among detected persons, a person identical or resembling the target person (i.e., a person having a similarity score not lower than a threshold value) as a person of interest.", "In addition, the person-of-interest detector 26 can detect the position, size and region of a person of interest, the region of the upper body of a person-of-interest, the position, size, region and direction of the face of a person of interest, and the like, in frame images.", "Methods of detecting a person, a person's face and other elements in frame images are known and will not be described in detail.", "Specific details of such detecting methods are not limited in any way.", "A method of detecting a person of interest is also not limited.", "The movement trajectory detector 28 detects a movement trajectory of a person of interest by tracking the movement of the person of interest in a moving image based on results of person-of-interest detection done by the person-of-interest detector 26 with a plurality of frame images.", "By detecting a movement trajectory of a person of interest, the movement trajectory detector 28 can also detect the length of movement trajectory of the person of interest, a moving pattern of the person-of-interest, a period of time during which the person of interest is continuously present in a moving image.", "For a movement trajectory of a person of interest, use may be made of an image of a trajectory in the form of line resulting from the movement of a region of interest (ROI), e.g., a face region of a person of interest as shown to the left of any of FIGS.", "3A to 3C.", "Alternatively, for a movement trajectory of a person of interest, a motion history image (MHI) may be used as shown to the right of any of FIGS.", "3A to 3C.", "The motion history image shows the history of motion of a person of interest with the color changing at certain time intervals.", "The use of such a motion history image makes it possible to know, for instance, the position, size, moving portion and moving direction of a person of interest.", "The movement trajectory detector 28 can track the movement of a person of interest in a moving image by, for instance, with the use of a face region of the person of interest, comparing the face region of the person of interest in a frame image of a present frame with a detecting region at a given position corresponding to the face region of the person of interest in a frame image of the next frame, and based on the position of the detecting region in the frame image of the next frame in which position the similarity score with respect to the face region of the person of interest in the frame image of the present frame is not lower than a threshold value, detecting a position of the detecting region in the frame image of the next frame to which position the face region of the person of interest in the frame image of the present frame has moved.", "Only with the detection of a face region of a person of interest, a difficulty may arise in tracking the movement of the person of interest because the position, size and the like of the person of interest changes with time in frame images.", "To cope with it, the upper body of a person of interest is divided into a certain number of regions, e.g., four regions, and the movement of the person of interest is tracked separately for the four regions in addition to the face region, that is, five regions in total.", "Thus, the success rate of tracking can be improved.", "When the similarity is determined between a face region of a person of interest in a frame image of a present frame and a detecting region in a frame image of the next frame, in order to detect, in the frame image of the next frame, a detecting region at a position corresponding to the face region of the person of interest in the frame image of the present frame, the calculation of the sum of brightness values of all pixels within a detecting region at a given position has to be repeated for respective detecting regions at plural positions in sequence.", "Accordingly, an enormous amount of calculation is required to calculate the sum of brightness values for every frame.", "In this case, the amount of calculation can be reduced by producing an integral image of a frame image of the next frame (i.e., each frame) and calculating the sum of brightness values using the produced integral image, thereby speeding up the processing.", "Assuming that pixel coordinates of a frame image increases from left to right and top to bottom, the integral image is an image in which a pixel at each set of coordinates has an integral value of brightness values from the pixel at the upper left corner through each pixel at each set of coordinates.", "Methods of calculating the sum of brightness values of all pixels within a region corresponding to a face region of a person of interest are known and therefore will not be described in detail.", "Besides, when the movement of a person of interest is tracked, the use of an integral image is not essential in reducing the amount of calculation and speeding up the processing, and various methods such as mean shift are applicable.", "Mean shift is also known and the details thereof are not given.", "The motion analyzer 30 analyzes the motion of a person of interest in a moving image based on a movement trajectory of the person of interest, e.g., a region of interest such as a face region, detected by the movement trajectory detector 28.The motion analyzer 30 defines movement trajectories of a person of interest beforehand, such as a movement trajectory of the person of interest when he/she is running, detects, from a movement trajectory of the person of interest detected by the movement trajectory detector 28, a portion similar to any of the movement trajectories defined beforehand, and analyzes the motion of the person of interest.", "The motion analyzer 30 can also use such motion history images as shown to the right of FIGS.", "3A to 3C as movement trajectories of a person of interest in analyzing the motion of the person of interest.", "Through analysis of the motion of the person of interest based on the motion history images, the motion analyzer 30 can recognize that, for example, the person of interest is running from right to left in FIG.", "3A as shown to the right of FIG.", "3A, the person of interest stands still and moves only his/her right hand as shown to the right of FIG.", "3B, and the person of interest is picking up something on the ground as shown to the right of FIG.", "3C.", "The importance determiner 32 determines the importance of each frame image based on at least one of the length of movement trajectory of a person of interest, the position of the person of interest in a frame image, and the size of the person of interest in a frame image.", "For example, when a movement trajectory of a person of interest is long (i.e., longer than a threshold value), this makes it possible to estimate that a shooting person has a strong interest in the person of interest.", "Accordingly, the importance determiner 32 determines that the importance of frame images corresponding to the long movement trajectory of the person of interest is high in the moving image.", "The importance determiner 32 also determines that the importance of a frame image in which a person of interest is positioned in the center of the frame or large (i.e., larger than a threshold value) in the frame is high.", "The composition analyzer 34 analyzes the composition of each frame image to determine whether the composition is good based on at least one of the position of a person of interest in a frame image, the size of the person of interest in a frame image, and a moving pattern of the person of interest.", "The composition analyzer 34 determines that, for instance, the composition of a frame image in which a person of interest is positioned in the center of the frame or large (i.e., larger than a threshold value) in the frame is better than that of a frame image in which the person of interest is not positioned in the center of the frame or is not large in the frame.", "The composition analyzer 34 defines moving patterns of a person of interest beforehand, such as a moving pattern of the person of interest when he/she moves from the left end to the right end in a moving image, and detects, from a movement trajectory of the person of interest detected by the movement trajectory detector 28, a portion where the person of interest moves in any of the defined moving patterns.", "The composition analyzer 34 determines that the composition of frame images corresponding to the portion where the person of interest moves in any of the defined moving patterns is good.", "The image quality determiner 36 determines the image quality of each frame image using a region, e.g., a region of interest such as a face region of a person of interest in a frame image.", "Frame images extracted from a moving image may be good or bad in image quality depending on compression method of the moving image.", "In addition, frame images may be blur due to poor focusing, camera shake or another reason, or may be improper in terms of, for instance, brightness, hue or contrast.", "Even when, however, the image quality is poor in a background portion, if the image quality is good in a region of interest, namely a face or body region of a person of interest, the image quality analyzer 36 determines that the image quality of the frame image is good.", "Whether the image analyses by the person-of-interest detector 26, the movement trajectory detector 28, the motion analyzer 30, the importance determiner 32, the composition analyzer 34 and the image quality determiner 36 are performed is determined in accordance with the image analysis condition determined by the image analysis condition determiner 18.In the case of applying a dense image analysis condition, all of the image analyses above are performed.", "In the case of applying a rough image analysis condition, a smaller number of image analyses are performed compared to the case of applying the dense image analysis condition.", "For instance, the image analyses by the movement trajectory detector 28 and the motion analyzer 30 are not performed.", "The frame image output section 22 calculates evaluation values of each frame image based on a result of the image analysis by the motion analyzer 30 or results of the image analyses by the motion analyzer 30, the importance determiner 32, the composition analyzer 34 and the image quality determiner 36 and outputs, of frame images extracted from a moving image by the frame image extractor 24, a frame image having a high evaluation value (i.e., an evaluation value not lower than a threshold value) as a frame image corresponding to a best shot.", "In other words, the frame image output section 22 calculates an evaluation value of each frame image from the aspect of the motion of a person of interest based on the motion of the person of interest in a moving image analyzed by the motion analyzer 30.For example, the frame image output section 22 can calculate an evaluation value for the motion of a person of interest depending on the type of the motion of the person of interest in such a manner that specified points are given as the evaluation value when the motion of the person of interest is run.", "In addition, the frame image output section 22 calculates an evaluation value for the motion of a person of interest analyzed by the motion analyzer 30 based on such a motion history image as shown to the right of any of FIGS.", "3A to 3C, which is regarded as a movement trajectory of the person of interest.", "For example, the frame image output section 22 can calculate an evaluation value for the motion of a person of interest based on results of determination as to whether, where and in which direction the person is moving.", "In addition, the frame image output section 22 calculates an importance evaluation value of each frame image based on the importance of each frame image determined by the importance determiner 32.For example, the frame image output section 22 can calculate an importance evaluation value in such a manner that the evaluation value increases with higher importance.", "In addition, the frame image output section 22 calculates a composition evaluation value of each frame image based on a result of determination made by the composition analyzer 34 as to whether the composition of each frame image is good.", "For example, the frame image output section 22 can calculate a composition evaluation value in such a manner that the evaluation value of a frame image with the composition determined to be good is higher than that of a frame image with the composition determined to be not good.", "In addition, the frame image output section 22 calculates an image quality evaluation value of each frame image based on the image quality of each frame image determined by the image quality determiner 36.For example, the frame image output section 22 can calculate an image quality evaluation value in such a manner that, for frame images determined to have good image quality, the evaluation value increases with better image quality.", "For example, the degree of blur in a region of interest is determined, and the image quality evaluation value is calculated in such a manner that the evaluation value decreases with a higher degree of blur.", "The frame image output section 22 outputs, of a plurality of frame images extracted from a moving image by the frame image extractor 24, at least one frame image having an evaluation value for the motion of a person of interest or a total evaluation value obtained by adding at least one of importance, composition and image quality evaluation values to an evaluation value for the motion of a person of interest being not lower than a threshold value, as a frame image corresponding to a best shot.", "Next, the operation of the image processing device 10 shown in FIG.", "1 is described with reference to the flowchart of FIG.", "4.In the image processing device 10, first, the image acquiring section 12 acquires a moving image and a plurality of still images to be subjected to the processing (Step S1).", "The characteristic information extractor 14 extracts, from the still images, the number of times the same person appears, as characteristic information (Step S2).", "Based on the characteristic information, the target object detector 16 detects, for instance, a person who appears many times, as a target person (Step S3).", "Based on the characteristic information and the target person, the image analysis condition determiner 18 sets an image analysis condition for a portion of the moving image which portion has low relevance with the still images to be rougher than that for a portion of the moving image which portion has high relevance with the still images (Step S4).", "For instance, the frequency of extracting frame images from a portion of the moving image where a person of interest, who appears many times, is absent is set to be less than that of extracting frame images from a portion of the moving image where the person of interest is present.", "Subsequently, the frame image analyzer 20 extracts frame images from the moving image and performs the image analysis on the extracted frame images in accordance with the image analysis condition (Step S5).", "The operation of the frame image analyzer 20 will be detailed later.", "Based on a result of the image analysis, the frame image output section 22 calculates an evaluation value of each frame image and outputs, of the frame images extracted from the moving image, a frame image having a high evaluation value as a frame image corresponding to a best shot (Step S6).", "In the image processing device 10, characteristic information is extracted from still images; based on the characteristic information, an image analysis condition for a portion of a moving image where a person of interest, who appears many times, is absent is set to be rougher than that for a portion of the moving image where the person of interest is present; and frame images are extracted from the moving image and analyzed.", "This configuration makes it possible to extract a frame image corresponding to a best shot from a moving image accurately, efficiently and rapidly.", "Next, the operation of the frame image analyzer 20 is described with reference to the flowchart shown in FIG.", "5.In the frame image analyzer 20, first, the frame image extractor 24 extracts frame images from the moving image in accordance with the image analysis condition (Step S7).", "In this step, for instance, frame images are extracted from a portion of the moving image where a person of interest is absent with less extraction frequency than that in the case of extracting frame images from a portion of the moving image where the person of interest is present.", "The person-of-interest detector 26 detects, in the frame images extracted by the frame image extractor 24, a person (person of interest) identical or resembling the target person detected by the target object detector 16 (Step S8).", "In this step, the person of interest is identified in each frame image, while the position, size, region and the like of the person of interest in each frame image are detected.", "Based on the results of person-of-interest detection with the frame images, the movement trajectory detector 28 detects a movement trajectory of the person of interest by, for instance, tracking the movement of a region of interest of the person of interest in the moving image (Step S9).", "In this step, as the movement trajectory of the person of interest, for instance, there can be obtained an image of a trajectory in the form of line resulting from the movement of a region of interest such as a face region as shown to the left of any of FIGS.", "3A to 3C or a motion history image as shown to the right of any of FIGS.", "3A to 3C.", "Based on the movement trajectory of the person of interest detected by the movement trajectory detector 28, the motion analyzer 30 analyzes the motion of the person of interest in the moving image (Step S10-1).", "Based on the length of the movement trajectory of the person of interest and the position and size of the person of interest in each frame image, the importance determiner 32 determines the importance of each frame image (Step S10-2).", "Based on the position and size of the person of interest in each frame image and the moving pattern of the person of interest, the composition analyzer 34 determines whether the composition of each frame image is good (Step S10-3) The image quality determiner 36 determines the image quality of each frame image using a region of the person of interest in each frame image (Step S10-4).", "The order of determining evaluation values for the motion of the person of interest, the importance, the composition and the image quality is not limited, and the evaluation values may be calculated in any order.", "Alternatively, those evaluation values may be calculated in parallel, i.e., simultaneously.", "Whether the image analyses by the person-of-interest detector 26, the movement trajectory detector 28, the motion analyzer 30, the importance determiner 32, the composition analyzer 34 and the image quality determiner 36 are performed is determined in accordance with the image analysis condition.", "For instance, the number of items of image analysis performed on frame images extracted from a portion of the moving image where the person of interest, who appears many times, is absent is set to be smaller than that of items of image analysis performed on frame images extracted from a portion of the moving image where the person of interest is present.", "Subsequently, based on a result of the image analysis by the motion analyzer 30 or results of the image analyses by the motion analyzer 30, the importance determiner 32, the composition analyzer 34 and the image quality determiner 36, the frame image output section 22 calculates an evaluation value of each frame image (Step S11).", "In other words, an evaluation value for the motion of the person of interest or evaluation values for the motion of the person of interest, the importance, the composition and the image quality are calculated for each frame image.", "Finally, of the frame images extracted from the moving image by the frame image extractor 24, at least one frame image having a high evaluation value for the motion of the person of interest or having a total evaluation value (sum of evaluation values) obtained by adding evaluation values for the motion of the person of interest, the importance, the composition and the image quality being high, is output as a frame image corresponding to a best shot (Step S12).", "As described above, in the image processing device 10, based on an evaluation value for the motion of a person of interest in a moving image or a total evaluation value including an evaluation value for the motion of the person of interest in the moving image and evaluation values for the importance, the composition and the image quality of frame images, a best shot can be automatically detected in the moving image, and a frame image corresponding to the best shot can be extracted from among frame images extracted from the moving image.", "When two or more persons of interest are present, the person-of-interest detector 26 can detect each of the two or more persons of interest in a plurality of frame images and sequentially determine who the detected two or more persons of interest are.", "In this case, the movement trajectory detector 28, the motion analyzer 30, the importance determiner 32, the composition analyzer 34, the image quality determiner 36 and the frame image output section 22 sequentially perform their processing on each of the two or more persons of interest.", "The above description applies also when the target subject, which is a target object, is an animal or an object.", "However, the description of the detection of a person of interest, the detection of a movement trajectory and the motion analysis applies only when the target subject is a living body such as a person or an animal.", "As described above, the image processing device 10 can detect, as a person of interest, a person who appears many times in a plurality of still images that were acquired together with a moving image and extract a frame image in which the person of interest is present from the moving image.", "For instance, when a plurality of still images associated with each class of a school (e.g., a group photograph of each class, photographs showing various combinations of close friends belonging to the same class) are, together with a moving image, input to the image processing device 10, frame images showing a child or children of each class are mainly extracted on a class basis.", "When a plurality of still images showing a child or children of a parent(s) are, together with a moving image, input to the image processing device 10, frame images showing the child or children of the parent(s) are mainly extracted.", "In extracting frame images in which a person of interest is present from a moving image, a conventional image processing device extracts all frame images of frames from the start of the moving image and performs various image analyses on every frame image, as shown in FIG.", "6A.", "In FIG.", "6A, frame images of solid line represent extracted ones.", "Accordingly, such a conventional image processing device requires a long period of time for extraction of frame images from a moving image and following image analyses and is thus incapable of rapidly extracting a frame image corresponding to a best shot from a moving image.", "In the image processing device 10, the frequency of extracting frame images from a portion of a moving image where a person of interest is absent is set to be less than that of extracting frame images from a portion of the moving image where the person of interest is present.", "As shown in FIG.", "6B, when a face (person) is not detected or when a detected face (person) is not a person of interest, one frame image is extracted per thirty frames from a moving image, for example.", "In FIG.", "6B, frame images of solid line represent extracted ones and frame images of dashed line represent unextracted ones.", "When a person of interest is present, one frame image is extracted per frame from a moving image.", "Since the frequency of extracting frame images from a portion of a moving image where a person of interest is absent is set to be less than that of extracting frame images from a portion of the moving image where the person of interest is present, only a frame image to be output as one corresponding to a best shot can be extracted from a moving image in a short period of time and subjected to the image analysis.", "Accordingly, a frame image corresponding to a best shot can be extracted from a moving image accurately, efficiently and rapidly.", "A frame image extracted from a portion of a moving image where a person of interest is absent is not output as one corresponding to a best shot and therefore, no problem arises even if the frequency of extracting frame images is reduced in the portion of the moving image where the person of interest is absent.", "While the case of detecting a face (person) has been described in the foregoing, the invention is not limited thereto and the detection of an animal, such as a pet, an object, or a scene may be used to extract a frame image corresponding to a best shot and output the extracted frame image.", "The image analysis condition determiner 18 may change the frequency of extracting frame images from a moving image depending on the type of the subject (person, animal, object, scene or the like).", "For example, when at least one living thing of a person and an animal is present, it is desirable to increase the frequency of extracting frame images from a portion of a moving image where the living thing is present in order to detect a movement trajectory.", "In contrast, when a living thing is absent and a non-living thing such as an object is present, a movement trajectory is not detected and therefore, no problem arises even if the frequency of extracting frame images from a portion of a moving image where a living thing is absent is set to be less than that of extracting frame images from a portion of the moving image where a living thing is present.", "The image analysis condition determiner 18 may change the frequency of extracting frame images from a moving image depending on the contents of frame images.", "For instance, when the size of a face is large, this means that the face was shot at close range and the subject's movement is probably large.", "Therefore, when a frame image is extracted from a portion of a moving image where at least one living thing of a person and an animal is present and appears in a large size (i.e., a size larger than a threshold value), it is desirable to, for instance, extract a frame image per frame or increase the frequency of extracting frame images.", "On the other hand, when the size of a face is small, this means that the face was shot at long range and the subject's movement is probably small.", "Therefore, when a frame image is extracted from a portion of a moving image where a living thing appearing in a large size (i.e., a size larger than a threshold value) is absent, even if the frequency of extracting frame images is set to be less than that of extracting frame images from a portion of the moving image where a living thing appearing in a large size is present, no problem arises.", "As characteristic information, the shooting time of each still image can be used.", "In this case, it is not necessary to output a frame image shot in the same time range as a time range which overlaps the time a still image was shot, as a frame image corresponding to a best shot.", "In response to this, the image analysis condition determiner 18 may set an image analysis condition for a portion of a moving image which portion was shot within a shooting time range covering certain periods of time before and after the shooting time of a still image, to be rougher than that for a portion of the moving image which portion was shot within a shooting time range other than the shooting time range covering certain periods of time before and after the shooting time of the still image.", "When, for instance, the image analysis condition is the frequency of extracting frame images, the image analysis condition determiner 18 sets the frequency of extracting frame images from a portion of a moving image which portion was shot within a shooting time range covering certain periods of time before and after the shooting time of a still image, to be less than that of extracting frame images from a portion of the moving image which portion was shot within a shooting time range other than the shooting time range covering certain periods of time before and after the shooting time of the still image.", "When the image analysis condition is the number of items of image analysis, the image analysis condition determiner 18 sets the number of items of image analysis performed on frame images extracted from a portion of a moving image which portion was shot within a shooting time range covering certain periods of time before and after the shooting time of a still image, to be smaller than that of items of image analysis performed on frame images extracted from a portion of the moving image which portion was shot within a shooting time range other than the shooting time range covering certain periods of time before and after the shooting time of the still image.", "For example, the number of items of image analysis performed on frame images extracted from a portion of a moving image which portion was shot within a shooting time range other than a shooting time range covering certain periods of time before and after the shooting time of a still image, is set to two or more selected from among person detection, person's motion analysis, detection of a period of time during which a person is continuously present in a moving image, composition analysis, and image quality determination.", "On the other hand, the number of items of image analysis performed on frame images extracted from a portion of the moving image which portion was shot within the shooting time range covering certain periods of time before and after the shooting time of the still image, is set to be smaller than the number of items of image analysis performed on frame images extracted from the portion of the moving image where the target subject is present.", "When the image analysis condition is the image size of a frame image in image analysis, the image analysis condition determiner 18 sets the image size, in image analysis, of a frame image extracted from a portion of a moving image which portion was shot within a shooting time range covering certain periods of time before and after the shooting time of a still image, to be smaller than the image size, in image analysis, of a frame image extracted from a portion of the moving image which portion was shot within a shooting time range other than the shooting time range covering certain periods of time before and after the shooting time of the still image.", "For example, when the image size of a frame image extracted from a moving image is 800×600 pixels, the image size, in image analysis, of a frame image extracted from a portion of the moving image which portion was shot within a shooting time range other than a shooting time range covering certain periods of time before and after the shooting time of a still image is set to 800×600 pixels (no scale-down), whereas the image size, in image analysis, of a frame image extracted from a portion of the moving image which portion was shot within the shooting time range covering certain periods of time before and after the shooting time of the still image is reduced to 400×300 pixels.", "An important image must have been shot as a still image, and it is necessary to extract only a frame image having a remarkably high evaluation value from a portion of a moving image which portion was shot within a shooting time range covering certain periods of time before and after the shooting time of a still image.", "Therefore, no problem arises even if the image size of the frame image in image analysis is reduced.", "The image analysis condition determiner 18 may simultaneously set one or more out of image analysis conditions including the frequency of extracting frame images, the number of items of image analysis, and the image size of a frame image in image analysis, to be rough.", "When the image acquiring section 12 acquires a plurality of moving images, the image analysis condition determiner 18 may set an image analysis condition so as not to allow the extraction of any frame image from, of the acquired moving images, a moving image shot within a shooting time range including the shooting time of a still image.", "For example, when the shooting time range of a moving image A starts at 10:12:20 and ends at 10:14:09, the shooting time range of a moving image B starts at 10:23:55 and ends at 10:27:10, and the shooting time of a still image is 10:24:30, no frame image is extracted from the moving image B.", "The image analysis condition determiner 18 may set an image analysis condition so as not to allow the extraction of any frame image from a portion of a moving image which portion was shot within a shooting time range covering certain periods of time before and after the shooting time of a still image, for instance, a shooting time range covering thirty seconds before and thirty seconds after the shooting time of the still image.", "Thus, in the image processing device 10 in this embodiment, it is possible to partially omit the processing for some moving images out of a plurality of moving images or a part of a moving image over a certain time range.", "Therefore, the processing speed can be improved.", "Instead of determining a range of a moving image from which range frame images are extracted, the image analysis condition determiner 18 may set the frequency of extracting frame images from a portion of a moving image which portion was shot within a shooting time range covering certain periods of time before and after the shooting time of a still image, to be less than that of extracting frame images from a portion of the moving image which portion was shot within a shooting time range other than the shooting time range covering certain periods of time before and after the shooting time of the still image.", "For instance, one frame image is extracted per thirty frames from a portion of a moving image which portion was shot within a shooting time range covering certain periods of time before and after the shooting time of a still image, while one frame image is extracted per frame from a portion of the moving image which portion was shot within a shooting time range other than the shooting time range above.", "The image analysis condition determiner 18 may set the number of items of image analysis performed on frame images extracted from a portion of a moving image which portion was shot within a shooting time range covering certain periods of time before and after the shooting time of a still image, to be smaller than that of items of image analysis performed on frame images extracted from a portion of the moving image which portion was shot within a shooting time range other than the shooting time range covering certain periods of time before and after the shooting time of the still image.", "For example, for frame images extracted from a portion of a moving image which portion was shot within a shooting time range covering certain periods of time before and after the shooting time of a still image, the detection of a movement trajectory and the motion analysis are performed but the detection of a person of interest is not performed.", "For frame images extracted from a portion of a moving image which portion was shot within a shooting time range other than the shooting time range above, in addition to the detection of a movement trajectory and the motion analysis, the detection of a person of interest is also performed.", "However, when, for example, a frame image having a high importance evaluation value exists within a shooting time range covering certain periods of time before and after the shooting time of a still image, one frame image may be extracted per frame from a portion of a moving image which portion corresponds to several frames present before and after the frame image having a high importance evaluation value.", "When, for instance, a beanbag toss game in a sports day was shot for both a moving image and still images and there is a still image shot at the same time as the shooting time of a frame image extracted from the moving image, it is pointless to use the frame image extracted from the moving image.", "Therefore, the frame image output section 22 preferably sets an evaluation value for a frame image having been shot within the same time range as a time range during which, of a plurality of still images, at least one still image was shot, to be lower than that for a frame image having been shot within a time range different from (not same as) the time range during which the still image was shot, as shown in Table 1.The same time range herein may refer to a shooting time range, for example, covering thirty seconds before and thirty seconds after the shooting time of a still image, or a time range corresponding to the same scene.", "TABLE 1 Evaluation value Shooting time of still image is taken into account only based on Same time range as Different time range from moving image that of still image that of still image A B A B C B C D C D D D Table 1 illustrates a method of determining evaluation values of four frame images.", "The evaluation values of the four frame images only based on the associated moving image are A, B, C and D. The evaluation is the highest at A, decreases in the order of B, C and D, and is the lowest at D. Taking account of the shooting time of a still image, when the frame images were shot within the same time range as a time range during which the still image was shot, the evaluation values of the four frame images are decremented by one degree, that is, to B, C, D and D. When the four frame images were shot within a time range different from the time range during which the still image was shot, their evaluation values are unchanged and remain at A, B, C and D. Alternatively, the frame image output section 22 may set an evaluation value for a frame image that was shot within the same time range as a time range during which, of a plurality of still images, at least one still image was shot and that was shot at the same shooting time as that of the still image (i.e., a frame image shot within a shooting time range covering certain periods of time before and after the shooting time of the still image), to be lower than that for a frame image that was not shot in the same time range and at the same shooting time (i.e., a frame image shot within a shooting time range other than the shooting time range covering certain periods of time before and after the shooting time of the still image).", "The frame image that was shot at the same shooting time herein may refer to a frame image shot during, compared to the foregoing time range, a shorter time range covering certain periods of time (e.g., three seconds) before and after the shooting time of a still image.", "TABLE 2 Shooting time of still image is taken into account Same time range as Evaluation that of still image Different value only There is still There is no still time range based on image of same image of same from that of moving image shooting time shooting time still image A D B A B D C B C D D C D D D D In Table 2, the evaluation values of four frame images only based on the associated moving image are A, B, C and D as with the above case.", "Taking account of the shooting time of a still image, when the four frame images were shot within the same time range as a time range during which the still image was shot and also shot at the same shooting time as that of the still image, the evaluation values of all the images are decremented to the lowest level, that is, D. When the four frame images were shot within the same time range as the time range during which the still image was shot but not shot at the same shooting time as that of the still image, the evaluation values of the images are decremented by one degree, that is, to B, C, D and D. When the four frame images were shot within a time range different from the time range during which the still image was shot, their evaluation values are unchanged and remain at A, B, C and D. Alternatively, taking account of the shooting positions and shooting directions of still images and frame images, when a frame image that was shot within the same time range as a time range during which a still image was shot and that was also shot at the same shooting time as that of the still image is different from the still image in at least one of the shooting position and direction, the frame image output section 22 may retain or even raise the evaluation value for the frame image shot within the same time range and also at the same shooting time.", "Thus, by taking account of shooting times of still images, it is possible to remove a time range with low importance in advance.", "In the actual processing, upon determination of the importance, frame images in an important time range are output as files so that the frame images can be reused later.", "Since the present embodiment is configured to take account of shooting times of still images and remove in advance frame images in a non-important time range, frame images to be output as files can be narrowed down, which results in reduced processing time in outputting such frame images as files.", "For information on shooting times of still images and shooting positions and directions of still images and frame images, use may be made of information included in exchangeable image file format (EXIF) information attached to the still images and the frame images as header information.", "When the same subject appears a few times (i.e., the number of times less than a threshold value) in a plurality of still images, the frame image output section 22 may reduce a threshold value for use in determining whether a frame image is output as one corresponding to a best shot, to a smaller value than a threshold value used in the case where the same subject appears many times (i.e., the number of times not less than the threshold value).", "In this case, for instance, frame images showing a person who appears a few times in a plurality of still images are output as frame images corresponding to best shots, more than frame images showing a person who appears many times in the still images.", "This can prevent the number of frame images showing a person who appears not many times from being too small, so that the total number of still and frame images showing each of shot persons can be uniform.", "As characteristic information, information on a result of person recognition for each still image can be used.", "In this case, the image analysis condition determiner 18 may set an image analysis condition in such a manner to allow the extraction of a frame image showing a person corresponding to information on a person recognition result, from a moving image.", "As characteristic information, information on a result of scene determination or object recognition for each still image can be used.", "In this case, the image analysis condition determiner 18 may set an image analysis condition in such a manner to allow the extraction of a frame image showing a scene corresponding to information on a scene determination result or a frame image showing an object corresponding to information on an object recognition result, from a moving image.", "To be more specific, when a still image showing “autumn leaves” is input, frame images with “autumn leaves” scenes are extracted from a moving image using scene determination.", "When a still image showing a “child's hand” is input, frame images with “child's hand” scenes are extracted from a moving image using object recognition.", "As characteristic information, information on person's movement in each still image can be used.", "In this case, the image analysis condition determiner 18 may set an image analysis condition in such a manner to allow the extraction of a frame image in which a person exhibiting movement corresponding to information on person's movement is present, from a moving image.", "To be more specific, when a still image showing a “jumping child” is input, frame images with “jumping child” scenes are extracted from a moving image using the movement of a person in the moving image.", "When a moving image and a plurality of still images are simultaneously shot by a single shooting device, the shooting times of the moving and still images are identical; however, when a moving image and a plurality of still images are shot by different shooting devices, there may be a difference between the shooting times of the moving and still images.", "In the present invention, a moving image and a plurality of still images may be shot by a single shooting device or two or more shooting devices, and in the case of shooting moving and still images by two or more shooting devices, it is preferable to synchronize the shooting times of the moving and still images before the image analysis is performed on frame images.", "The device of the present invention may be composed of constituent elements that are dedicated hardware devices or composed of a computer in which operations of the constituent elements are programmed.", "The method of the present invention can be carried out by, for instance, a program that causes a computer to implement steps of the method.", "A computer readable recording medium having the program recorded thereon may also be provided.", "While the present invention has been described above in detail, the invention is not limited to the above embodiment, and various improvements and modifications may be made without departing from the spirit and scope of the invention." ] ]
Patent_15874420