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Clinical and laboratory predictors of all-cause mortality in older population. Although some clinical and laboratory tests have been studied on their individual relationship with total mortality or cause-specific mortality such as cardiovascular mortality, the overall effect of these indicators on mortality has rarely been evaluated. The purposes of this study were to assess the relationship of clinical and laboratory measures and all-cause mortality and to evaluate their potential clinical importance in mortality prediction in older adults. A sample of 2086 persons aged 65 and older participating the population-based health examination in 1995 and 1996 in Kaohsiung City, Taiwan was followed until the end of 2003. All participants completed medical history and underwent clinical assessment and laboratory tests. Measures selected for analysis were pulse rate, blood pressure, height, weight, serum level of cholesterol, triglyceride, creatinine, and uric acid, fasting blood glucose (FBG), hemoglobin (HG) and red (RBC) and white blood cell (WBC) counts. Cox regression was used to select measures significant to total mortality. All participants were further classified into risk groups, based on disease history and values of measures identified from analyses, to evaluate mortality risk. A total of 409 deaths occurred during an average of 8.2 years of follow-up time. Among all 14 measures assessed individually, five (systolic blood pressure=SBP, creatinine, uric acid, FBG, and HG) were statistically related to total mortality. SBP (hazard ratio (HR)=1.22; 95% confidence interval (CI)=1.09-1.36), FBG (HR=1.18; CI=1.08-1.29), and HG (HR=0.81; CI=0.73-0.91) were further identified to have independent effect on total mortality in the multivariate analysis. Age- and sex-adjusted total mortality HRs for disease risk (with disease history but with normal biomedical values), biomedical risk (without disease history but with abnormal biomedical values), and combined risk groups (with disease history and with abnormal biomedical values) were 1.94 (CI=1.22-3.10), 2.08 (CI=1.57-2.76), and 2.45 (CI=1.83-3.27) compared with low risk group (without diseases history and with normal biomedical values). Results from this study reveal the importance of incorporating clinical and laboratory measures on the assessment of mortality in older adults. Establishing mortality risk profile based on both diseases conditions and inexpensive biomedical measures (for example, SBP, FBG and HG identified in the study) may help physicians in evaluating older persons' prognosis.
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TVA To Redeem Debt Securities March 7, 2013 KNOXVILLE, Tenn. The Tennessee Valley Authority, taking advantage of market conditions, will redeem one issue of bonds from its electronotes series on April 8, 2013. TVA will redeem all of its 2010, 4.3-percent electronotes due March 15, 2025. These securities are identified by the CUSIP number 88059TEZ0. Approximately $22.1 million of this series is currently outstanding. The notes will be redeemed at 100 percent of par value. The redemption price and any accrued interest will be paid to eligible holders through The Depository Trust Company. TVA’s electronotes program offers securities for retail investors in a variety of structures. The electronotes have maturities of up to 30 years, and certain issues are redeemable by TVA prior to maturity. TVA offers new electronotes from time to time, generally on a monthly basis. The Tennessee Valley Authority is a corporate agency of the United States that provides electricity for business customers and local power distributors serving 9 million people in parts of seven southeastern states. TVA receives no taxpayer funding, deriving virtually all of its revenues from sales of electricity. In addition to operating and investing its revenues in its electric system, TVA provides flood control, navigation and land management for the Tennessee River system and assists local power companies and state and local governments with economic development and job creation.
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This is a challenging hike with a variety of habitats and great views. North Fortuna Mountain, at 1291 feet, is the third-tallest mountain in Mission Trails Regional Park after Cowles Mountain and Pyles Peak but the most challenging to climb because of the steep ascent and descent. The route described includes views of Mission Dam, with a quick side trip possible, a shaded oak canyon with views to the open grasslands, riparian areas, and plenty of coastal sage scrub and mountain chaparral areas with a variety of plants. The true summit isn’t visible from the saddle. North Fortuna is part of a long-arced mountain with two peaks that was once called on century-old maps Long Mountain. North Fortuna is separated from South Fortuna by a 910-foot saddle. This area has a long military history beginning in 1917 when Fortuna was used as an artillery target for training during WWI by the U.S. Army based at Camp Kearny, a few miles to the west. The area was reactivated in 1934 by the U.S. Marines, becoming part of Camp Elliott; ten years later, it was transferred to the U.S. Navy. Fortuna was used for tank, artillery, and infantry training for both WWII and the Korean War. After a cleanup for live ordnance, the land was transferred to the City of San Diego in the 1960s. By the late 1970s, a master plan was created for Mission Trails Regional Park. On rare occasions, live ordnance may surface after heavy rainfall and should be reported and never handled. Hike west from the parking area past the turnoff to Mission Dam to a sign and a small footbridge over the San Diego River that leads into Oak Canyon. Several interpretive signs are found along this section of the trail. A wood fence separates the trail from the grasslands area to the east from the shaded oak woodland and riparian areas. Be careful of poison oak found under the coast live oaks. Other trees to note in this area include western sycamores, cottonwoods, and mule fat. At about mile 1.3 is the junction with the Oak Canyon North Trail to the right and the Fortuna saddle surface road to the left. Head left up this very steep half-mile route, gaining close to 500 feet in elevation at the 910-foot saddle. Take the trail to the right to head to the summit of North Fortuna. The first peak is not the true peak. Continue to the second peak at mile 2.3, which is the true summit. Look for several ammo cans nestled in the summit rocks. Write a note in one of the log books and/or read some of the entries written by hikers. Plants to note on the top include laurel sumac, mission manzanita, broom baccharis, and flat-top buckwheat. After taking in the view, which includes the flight runways for MCAS Miramar, traffic on SR-52, and the other peaks and trails in the park, begin the descent from the summit. At mile 2.93 is a junction with the Portobelo Trail heading down toward Suycott Wash or the Rolling Hills Trail that will lead to Oak Canyon North. Take the trail to the east and begin the rollercoaster descent of Rolling Hills that parallels SR-52. Extra care should be taken on this steep descent, best done with trekking polls. At mile 3.96 is the junction with Oak Canyon and the trail to the Grasslands. Follow the sign to the right into Oak Canyon North. This segment of the trail is especially delightful when water is running and there are pools of cool water. At mile 4.44 is the junction with the saddle service road and the close of the loop hike. Return to your vehicle following the original trail to this point. Distance from downtown San Diego: 18 miles. Allow 24 minutes (Mission Trails Regional Park). From SR-163N, merge onto SR-52E, exiting on Mast Blvd. and turning left under the freeway and then right on West Hills Parkway. Drive 0.7 mile to Mission Gorge Road and turn right. Proceed 0.3 mile on Mission Gorge Road and then turn right again on Father Junípero Serra Trail. Drive 0.4 mile to the small parking area for Mission Dam and park. If the lot is full, park along the road. Note that the parking area is only open until 7 p.m. Daylight Savings Time and 5 p.m. November through February. The gate is locked after closure time. Hiking length: 5.7-mile loop. Allow 3.5 hours. Difficulty: Moderately strenuous. Total elevation gain/loss about 2000 feet. Facilities and water available at the trailhead. Carry water. Trekking poles recommended for steep ascent and descent. Be alert for mountain bikes on the trail. Leashed dogs are allowed on trails.
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1. Field of the Invention The present invention relates to a sound emitting and/or illuminated toy xe2x80x9cice popxe2x80x9d. 2. Description of Related Art Toys which provide an element of mystery to a child have been commercially successful. One such type of toy was a doll marketed by DSI, Inc. under the trademark ROSIE. ROSIE would speak when an end user(s) held both of the doll""s hands. The hands each had an electrode that were coupled to a sound generating device within the doll. By grasping the doll""s hands the end user provided a switch that electrically coupled the electrodes. The coupled electrodes closed a circuit within the doll so that the sound generating device produced a sound. Tiger Electronics and Captoys, Inc. have both-marketed sound producing wands under the trademarks BUBBLE BOPPER and MUSICAL BUBBLE TUNES, respectively. The wands each had electrodes that were coupled to a sound generating device. The end user would create a liquid bubble and then try to place the electrodes in contact with the bubble. When in contact with the wand, the liquid bubble would provide a medium that electrically coupled the electrodes so that the sound device generated a sound. U.S. Pat. No. 4,914,748 issued to Schlotter, IV et al. discloses a novelty flashlight which illuminates a piece of candy when the end user depresses a button on a handle of the device. The present invention is a toy that emits a sound and/or emits light when an end user drinks a liquid through a straw. The toy includes a first electrode and a second electrode in fluid communication with an inner channel of the straw. The electrodes are connected to an indicator such as a light source or a sound generating device. When the end user drinks a liquid through the straw the liquid provides an electrical path between the electrodes. The liquid closes a circuit between the electrodes and activates the indicator. The present invention also includes a sound/light emitting toy which supports a piece of candy. The toy includes a first electrode that can be grasped by the end user and a second electrode that is in contact with the candy. The electrodes are connected to an indicator. By licking the candy the end user provides an electrical path between the electrodes which closes a circuit and activates the indicator.
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The objective of this proposal is to provide a multicategorical, multidepartmental Children's Clinical Research Center at Texas Children's Hospital. This facility will afford investigators an opportunity to carry out clinical research projects of high caliber on the pediatric subject and will provide a center for the integration of research efforts of many disciplines.
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Nicola Sturgeon today claimed Ed Miliband has 'lost the plot' after suggesting he would rather not be in power than rely on the SNP. Labour leader Mr Miliband last night sought to give the impression that Labour would have no truck with the SNP, but today senior frontbenchers insisted that 'of course' they would talk to other parties if they fail to secure a majority. But Ms Sturgeon seized on the remarks, claiming if Mr Miliband would rather let the Tories into power it would be 'the final nail in the coffin of Scottish Labour' and in other parts of the UK. Nicola Sturgeon today claimed Ed Miliband has 'lost the plot' after suggesting he would rather not be in power than rely on the SNP Share this article WHO SAID WHAT? LABOUR'S SHIFTING POSITION ON THE SNP Ed Miliband, Labour leader: 'We are not going to do a deal with the Scottish National Party. If it meant we would not be in government, then so be it.' Harriet Harman, deputy leader: 'If we form the government it's open to members of Parliament from other parties to support our programme when we are in government.' Ed Balls, shadow chancellor: 'I don't think there's any possibility of us working with the SNP. Categorically. Absolutely impossible.' Andy Burnham, shadow health secretary: 'Parties talk in the House of Commons about government business, that's what happens, all parties talk.' Caroline Flint, shadow energy secretary: 'At the end of the day, whoever forms a government, parties will get a chance to vote for a Queen's Speech, vote for budgets, and vote for policies, that's the same with any government.' Taking part in a Question Time special last night, Mr Miliband left the door open to relying on the party to prop up his government. SNP leader Nicola Sturgeon has said she will seek to put Mr Miliband in Number Ten even if Labour finishes 40 seats behind the Tories in a hung Parliament, in exchange for various concessions for Scotland. During last night's programme, Mr Miliband repeated his opposition to a coalition with the SNP, or a so-called 'confidence and supply' deal which would see the SNP guarantee to support Labour in key votes for a fixed period in exchange for concessions. Hardening his language, he said he would rather not enter Number Ten than enter such an arrangement. 'We are not going to do a deal with the Scottish National Party. If it meant we would not be in government, then so be it,' Mr Miliband said. 'I'm not going to give in to SNP demands – whether that is on Trident or on the deficit.'‎ Ms Sturgeon, campaigning in Dundee today, said people across the UK would be 'appalled' that Mr Miliband was willing to walk away from power. She said: 'If Ed Miliband is really saying he would rather have a Tory government than work with the SNP for more progressive politics, then it's final proof that Labour has lost the plot. 'It will be the final nail in the coffin of Scottish Labour, and I suspect Labour in other parts of the UK, and it makes it all the more important that we have a big team of SNP MPs because we will need them to protect Scotland from the Tories because clearly Ed Miliband is not prepared to do it.' She added: 'I think people across Scotland, and I suspect across other parts of the UK, will be appalled. 'If Ed Miliband is really saying that if there is an anti-Tory majority in the House of Commons and an opportunity to get the Tories out, he would stand back and watch David Cameron go back into Downing Street rather than work with the SNP, people in Scotland will never, ever forgive Labour if that turns out to be the case, and I suspect people in other parts of the UK won't forgive them either. 'I think Ed Miliband is saying these things because he's being bullied and bossed around by the Tories on this. 'I would have thought people who want to see an alternative to the Tories would rather see a Labour leader prepared to stand up to them. 'It's not a good sign when he's so easily bossed about by them.' Ed Miliband, speaking in Cardiff today, suggested he would rather walk away from power than form a coalition with the SNP but did not rule out rely on their votes in a minority government Balance of power: SNP leader Nicola Sturgeon, pictured today while campaigning in Musselburgh, Scotland, has said without her MPs Mr Miliband 'won't get his Budget through' if he becomes PM It came after Andy Burnham, Mr Miliband's chief leadership rival today admitted a minority Labour government will talk to the SNP to try to get its legislation through the Commons. The shadow health secretary said 'of course' Labour would have 'dialogue' with the resurgent Scottish Nationalists, on course to win more than 50 seats and hold the balance of power. Mr Burnham told BBC Radio 5 Live he simply 'being honest' and giving a 'statement of fact'. Labour's shadow energy secretary Caroline Flint made clear that the party would be prepared to be propped up by the SNP in key Commons votes. 'What he [Miliband] ruled out was this idea that, somehow, to have a Labour government we're prepared to do a coalition or some other kind of confidence and supply deal. 'But, at the end of the day, whoever forms a government, parties will get a chance to vote for a Queen's Speech, vote for budgets, and vote for policies, that's the same with any government,' Miss Flint said. The stunt sought to hammer home Conservatives claims that the SNP will help to make Ed Miliband Prime Minister Mr Miliband's refusal to rule out vote-by-vote negotiations came after Labour grandee David Blunkett raised the possibility of a minority Labour government backed in the Commons by votes from SNP MPs. The comments from the former Home Secretary, who admitted that Labour was unlikely to win the Election because of the SNP 'tsunami', will fuel growing alarm in the rest of the UK at the prospect of the Scottish Nationalists extracting a high price for propping up a weak Labour administration. Miss Sturgeon's party is on course to win more than 50 seats in Scotland and hold the balance of power at Westminster, and there is mounting Labour turmoil at polls suggesting their party – which has 41 MPs in Scotland – is facing a total wipeout at the hands of the nationalists. In a last-ditch attempt to halt the SNP surge, Mr Miliband will today appear at a campaign rally in Glasgow and urge voters: 'Don't gamble with the SNP.' David Cameron, campaigning at an Asda store in Leeds, insisted: 'What Ed Miliband said last night actually changes nothing. 'Because the polls show a potential wipeout for Labour in Scotland, they can only form a government if they have the support of the SNP. 'Is Ed Miliband really saying 'If Labour don't get a majority but Labour plus the SNP is a majority, I won't be prime minister'? Of course he isn't saying that. 'So the threat today is the same as the threat yesterday: Ed Miliband propped up by the SNP, not governing on behalf of the whole of the country. Labour shadow ministers have been out this morning confirming that.' Message: David Cameron, campaigning at an Asda store in Leeds this moring, has insisted: 'What Ed Miliband said last night actually changes nothing' Former Cabinet Secretary Gus O'Donnell last night warned an SNP landslide would 'put extra tension' on the UK, particularly if the party ends up holding the balance of power. Hinting at the perils of a Labour-SNP deal, Lord O'Donnell, now a crossbench peer, said an incoming government may face 'legitimacy issues'. Yesterday, Jim Sillars, a former deputy leader of the SNP, suggested the 'first line' of the party's manifesto for the 2016 Holyrood election could demand another independence vote. Miss Sturgeon said talk of another referendum was 'desperate scaremongering', but pressed on the issue, would say only: 'The people of Scotland are in charge.' Mr Blunkett, who is standing down as an MP, said voters in Scotland were beyond 'rational argument'. 'Once people have stopped listening, once their minds have switched off to even rational argument, then it's extremely difficult to win that back,' he told BBC Radio 4's World at One. 'It is though a great part of the Scottish nation have switched off, and that is so dangerous for the Union and for the future of Britain as a whole.' Mr Blunkett suggested Labour could rely on the SNP's votes to get legislation through. 'It's possible that we could put a minority government in place which did not have a formal agreement – was not in hock to and did not find itself run by a minority national nationalist party – but could expect them to actually vote on the things that they themselves have committed to,' he said. Conservative Party chairman Grant Shapps said: 'A former Labour Home Secretary admits what all the polls show – it is impossible for Ed Miliband to get the keys to Number Ten without being propped up by Nicola Sturgeon and Alex Salmond.'
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best led bathroom lighting ideas Decorating a bathroom with no natural light Sponsored Links Bathrooms with no natural light When it concerns interior lighting, shower rooms are most likely offered the least factor to consider of all the areas in our home. The ordinary client I meet doesn’t believe to spend there– save it for the living-room or cooking area, they say. I see a bunch of bathrooms with inadequate lighting at the mirror. Typically there’s merely a solitary ceiling fixture that’s intended to do everything. Yet as the washroom progressively comes to be an area to unwind as well as reenergize, complete with vapor shower and also health facility tub, the illumination requires added idea. And also when it’s done right, the payoff is fantastic. Nevertheless, this is the room where you begin and also end your day. A good lights strategy is a series of layers– putting sufficient light where it is required for showers, cutting, or placing on make-up, for instance, while other lights enhance the total state of mind of the room. Considering that these components work the hardest to light up the head as well as face for cleaning, Vanity lights acquires leading factor to consider. One of the most common mistake people make is placing recessed ceiling installations directly over the mirror. These cast shadows on the face, making day-to-day cleaning habits more difficult. Vertical fixtures or sconces installed on either side of the mirror are most effectively for casting an also light throughout the face. Plants for bathrooms with no natural light But provided the size and positioning of some vanity mirrors, sidelights can be not practical (placing them straight to the mirror is consistently a choice, however at better preparation and expense). Simply then do I suggest a component for over the mirror. It should be positioned 75 to 80 inches above the floor and also, like all vanity lighting, have at least 150 watts– ideally topped a component that goes to least 24 inches long to make sure that the light will certainly clean uniformly over the hair and face. The shower is a secondary area of job lights. In smaller sized washrooms, if the stall has a clear glass door, a committed installation might not be needed. Otherwise, I recommend a recessed light with a glass lens (plastic will certainly yellow). Comparable recessed components function more than a freestanding bathtub or the commode. When it comes to indoor lights, restrooms are most likely offered the least factor to consider of all the spaces in the residence. I see a lot of bathtubs with insufficient lights at the mirror. Vanity lights gets leading consideration due to the fact that these components function the hardest to brighten the head as well as face for cleaning. It ought to be placed 75 to 80 inches over the flooring and also, like all vanity lighting, contain at the very least 150 watts– preferably spread over a fixture that’s at least 24 inches long so that the light will clean equally over the hair as well as face. 14 Photos of the "Decorating a bathroom with no natural light" Related Post from "Decorating a bathroom with no natural light" Bathroom lighting A washroom mirror light is a crucial grooming accessory for both sexes in the 21st century. Guy spend just as much time in the shower room these days as their women counterparts, as well as why not there’s nothing wrong with would like to look your ideal. However mirror lights can do more... Wiring a bathroom light switch Lighting is just about the biggest components in any room in your house, including the bathroom. Restroom enough light is essential because it helps to distinguish concerning colorings even though salad dressing, or to keep it via sliding inside the bathroom. Right bathroom light is significant intended for security motives,... Box for bathroom light Restrooms could position a fascinating challenge to lighting design. Like kitchens, bathrooms need affordable as well as useful illumination options for a mainly task-oriented area. Brushing needs just the appropriate quantity of well-placed lights. How do you pick the ideal bathroom vanity lighting? There are a couple of points to take... Ceiling mounted bathroom light fixtures When it concerns interior lighting, shower rooms are most likely offered the least factor to consider of all the areas in our home. The ordinary client I meet doesn’t believe to spend there– save it for the living-room or cooking area, they say. I see a bunch of bathrooms with...
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Sure, I would have liked Thorin to sport a much larger beard, but I'm completely OKAY with his look. To me, Richard has all but nailed the character and that's the most important element. He's perfect in the warrior/arrogant sense and I truly get that he's a dwarf, a very important dwarf. So I'm fine with this representation. All that muttered, you do make some very valid arguments as to why Thorin would be even more perfect with a fuller beard. I'm thinking we might learn why his line have short beards, that could mean either youth or something significant to his particular family.
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1. Field of the Invention This application relates to an adapter for transferring dry chemicals to and from a storage container, such as a railroad car, truck, ship or storage tank and related system and method. The invention is particularly suitable for use with particulate chemicals which form hydrates which can contain difficult to handle particles or which include particles which tend to agglomerate, such as soda ash. 2. Description of Related Art Various means have been described for transferring dry materials out of containers. For example, U.S. Pat. No. 3,512,842 describes a method for unloading railcars in which a slurry is formed inside the railcar and then is pumped out. Such a process has numerous drawbacks, however, including the risk of overflowing or foaming within the car; the need for specialized railcars adapted for use in the slurrying process; the possibility of corrosive solutions being formed and damaging the railcar; problems with residual moisture causing caking in subsequent shipments; and the formation of hard, slowly dissolving lumps when liquid is added to a large quantity of solid. A similar approach is described in U.S. Pat. No. 4,189,262. Eductors have been used and are still used to transfer dry chemicals as a slurry, solution or solid. For example, liquid driven eductors have been used to slurry dry polymers and activated carbon in the water treatment industry and to transfer fly ash in the electric power industry. Also air, steam, and liquid driven eductors have been used for transfer of solids. However, problems are known to exist with eductor-based handling systems. For example, air driven eductors require a high power input and air flow per unit mass of solid conveyed resulting in high energy costs and higher capital cost for dust collection equipment. Steam driven eductors are used to create a vacuum for pneumatic conveying of dry solids to a solid-liquid mixing apparatus. The systems using steam driven eductors which are known to the inventors require a large amount of support equipment including a barometric leg for condensing the steam with modifications for solid-liquid mixing, and a large steam supply. Since the solid is conveyed by vacuum, the steam driven eductor system is limited by economics to installations where it can be located near, e.g. within a few hundred feet of, the container of dry chemical. Liquid driven eductors do not require large volumes of air or steam and can be used to transfer dry chemicals from a container, such as a railcar, forming a solution or slurry of the chemical in the liquid carrier medium. Liquid driven eductors are known to be successfully used to prepare dilute solutions of polymer in water as well as to transfer insoluble materials, e.g. activated carbon, to storage as a slurry. Commonly assigned U.S. Pat. No. 4,884,925, discloses an apparatus and method for transfer and slurrying or dissolving hydratable dry bulk chemicals hereby incorporated by reference. Briefly, this patent discloses an apparatus for the transfer of dry chemicals. The disclosed apparatus has a sealed solvation hopper positioned between a liquid driven eductor and a fitting for connection to a storage container such as a railroad car. At the inlet end of the solvation hopper is a chemical inlet pipe which connects the interior to the exterior of the hopper. Surrounding the chemical inlet pipe are a plurality of nozzles for introduction of solvation liquid into the hopper. The nozzles are disposed such that the solvation liquid washes the interior surface of the hopper to prevent plugging by hydrates (solvates) which may be formed. At the outlet end of the hopper is connected to a suction opening of the liquid driven eductor. In operation, liquid flowing through the eductor creates a suction and draws dry chemical out of the storage container and into the hopper. In the hopper, solvation liquid is supplied through the nozzles to wet the dry chemicals and to wash the surfaces of the hopper, pushing the wetted material toward the outlet end of the hopper. At the outlet end of the hopper, the wetted material is sucked out of the eductor where it is combined with the flow of eductor liquid. The material leaving the eductor is recovered and sent to storage or directly for processing. The process and apparatus are particularly useful for handling soda ash. Dry bulk solids, particularly soda ash, shipped in a particulate state are removed from the shipping containers as recited above and converted directly into a hydrate. By hydrated it is meant that the dry chemical is combined with water to form a mixture of water and particulate matter. The mixture can include a slurry and/or solution. Because such large quantities of dry particulate matter are handled there is a continuing problem of dealing with large particular impurities, insolubles, and soda ash which is lumped together by exposure to moisture. In particular, lumps of soda ash which form, are in the form of sodium carbonate decahydrate and are difficult to dissolve causing plugging in the hydrator, particularly in the mixing cone of the hydrator of the type disclosed in U.S. Pat. No. 4,884,925.
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A conventional solenoid valve used in a mass flow controller or the like to control the stroke of a valve element by balance between an attraction force of a fixed core and a restoring force of a plate spring may include for example a solenoid valve 100 of a normal closed type shown in FIG. 2. This solenoid valve 100 includes a body 101 formed with an inlet passage 102 and an outlet passage 104, and a valve seat 103 projecting upward at an upper opening of the inlet passage 102. A valve sheet 105 which can be brought into contact with or separated from the valve seat 103 is supported, together with a plunger 106, by a plate spring 107. The plate spring 107 is pressed by a retainer 108 of which the peripheral edge is engaged in the body 101. A bonnet 111 serving as a yoke is fitted on the retainer 108. In this bonnet 111, a fixed core 112 is centrally secured. This fixed core 112 is disposed in a coil bobbin 115 around which a coil 113 is wound so that the fixed core 112 protrudes downward from the coil bobbin 115 with a small clearance between the lower end surface of the fixed core 112 and the plunger 106. This solenoid valve 100 is normally held in a valve-closed state where the valve sheet 105 is pressed against the valve seat 103 by the spring force of the plate spring 107. When current is supplied to the coil 113, the fixed core 112 is magnetized, attracting the plunger 106 upward against the spring force of the plate spring 107. Accordingly, the valve sheet 105 is separated from the valve seat 103 to provide communication between the inlet passage 102 and the outlet passage 104, allowing control fluid to flow therethrough. When the amount of current to be applied to the coil 113 is changed, an electromaanetic attraction force will accordingly vary. Thus, the amount of stroke of the plunger 106 is changed to adjust the degree of valve opening between the valve seat 103 and the valve sheet 105. It is accordingly possible to control the flow rate of control fluid to be allowed to flow into a secondary side through the outlet passage 104. [Patent Document 1] Jpn. unexamined patent publication No. 2002-357280
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All relevant data are within the paper and its Supporting Information files. Introduction {#sec001} ============ Acute infections of the central nervous system (CNS) in children are usually severe and associated with high case fatality rates (CFR; 10--35%). Up to 15% have major neurological sequelae \[[@pone.0205316.ref001]--[@pone.0205316.ref003]\]. Late and/or inadequate treatment of bacterial meningitis is associated with poor outcome \[[@pone.0205316.ref004],[@pone.0205316.ref005]\]. To reduce such outcomes, CNS infections should be treated with an appropriate antimicrobial agent as early as possible \[[@pone.0205316.ref006]\]. Empiric antibiotic treatment is the standard of care for suspected bacterial CNS infections before the pathogen and its sensitivity to antimicrobials are confirmed by laboratory diagnosis. Inadequate treatment can result from antibiotic resistance or from inappropriate antibiotic choice for drug-sensitive bacterial infections. In sub-Saharan Africa, factors associated with high CFR of CNS infections include suboptimal health care access and late presentation \[[@pone.0205316.ref007]\]. Furthermore, the clinical diagnosis of bacterial meningitis is particularly challenging given the high prevalence of other infections presenting with a similar clinical picture, such as cerebral malaria. In rural areas, health workers first consulted are often of a lower cadre and require critical supervision to differentiate between competing diagnoses \[[@pone.0205316.ref008],[@pone.0205316.ref009]\]. Underutilization of lumbar puncture and poor access to microbiology services in many low-income countries contribute to poor knowledge of the local aetiology of bacterial meningitis and antibiotic resistance patterns \[[@pone.0205316.ref010]\]. Confronted with high mortality, especially within the first 48 hours of admission, clinicians in low income countries rely on empiric antimicrobial treatment for the management of children with suspected CNS infections, a strategy that is increasingly threatened by reduced antimicrobial susceptibility. Here we describe empiric antimicrobial treatment practices, antibiotic resistance and treatment adequacy in children with abnormal CNS symptoms and signs in the presence of bacterial or malaria infection in a regional referral hospital in Mbarara, Uganda. We focus on malaria and bacterial infections because of the limited ability to diagnose and assess treatment for viral infections. This is a secondary analysis of data collected within a study of the aetiology of suspected CNS infections published elsewhere \[[@pone.0205316.ref011]\]. Materials and methods {#sec002} ===================== Study population {#sec003} ---------------- The study took place in two hospitals, Mbarara Regional Referral Hospital (MRRH) and Holy Innocents Children's hospital (HICH) in Mbarara, located 300 km south-west of the capital Kampala. The prevalence of malaria in the Mbarara district ranges from 3% in urban areas to 23% in rural areas during the rainy season \[[@pone.0205316.ref012]\].Children between two months and 12 years admitted with suspicion of acute CNS infection based on fever or history of fever in the past 48 hours and recent onset of at least one sign of CNS involvement. CNS symptoms and signs included: non-traumatic reduced level of consciousness, prostration, hypertonia/hypotonia, irritability, severe headache, photophobia, neck stiffness, bulging fontanelle, prolonged seizures, focal neurological signs, purpura or Cheyne stokes breathing. Children who met the criteria above were enrolled into a prospective descriptive cohort study between August 2009 and October 2012. A more complete description of the study population and methods is provided elsewhere \[[@pone.0205316.ref011]\]. Clinical and laboratory investigations {#sec004} -------------------------------------- Socio-demographic and clinical characteristics of the participants including age, gender, HIV exposure, history and type of previous treatment as well as clinical information at admission and discharge and treatment received were recorded in a standardized case report form \[[@pone.0205316.ref011]\]. Diagnosis at admission was based on clinical examination and systematic testing with a rapid diagnostic test for malaria (SD-Bioline Malaria Antigen P.f/Pan, Standard Diagnostics, Korea). Final diagnosis was informed by biological investigations of blood and cerebrospinal fluid (CSF). Sample collection was performed systematically upon inclusion. Venous blood samples were collected aseptically into two single bottle blood-culture system (Signal Blood Culture System, Oxoid) and into EDTA tubes for hematological analyses. CSF was aseptically obtained by lumbar puncture into sterile CSF tubes. To diagnose bacterial pathogens, blood and CSF were analyzed at the Epicentre research laboratory on site following standardized bacteriology procedures \[[@pone.0205316.ref011]\]. Culture, staining, biochemical testing were used to identify any bacterial pathogens present. Drug susceptibility testing (DST) was done following the Comité De L'antibiogramme De La Société Francaise De Microbiologie (CA-SASFM 2006) guidelines \[[@pone.0205316.ref013]\]. We used the Kirby-Bauer disc diffusion method and E-tests to determine drug clearance zones and minimum inhibitory concentrations (MICs), respectively. In addition, real-time polymerase chain reaction (qPCR) was performed systematically on CSF to look for the following bacterial pathogens: *S*. *pneumoniae*, *H*. *influenzae* type b (Hib), *Salmonella*, *Listeria monocytogenes*, as well as viral pathogens not presented here. These qPCRs were carried out initially at Epicentre Research Laboratory, Mbarara and later at APHM Laboratory, Marseille, France, on CSF stored and transported at -80°C following standardized procedures \[[@pone.0205316.ref011]\]. Thick and thin blood smears were prepared from EDTA blood, Giemsa-stained and examined by microscopy as recommended by the World Health Organization (WHO) to confirm malaria infection \[[@pone.0205316.ref014]\]. Description of treatment guidelines {#sec005} ----------------------------------- Patients were treated by the attending ward clinician according to the treatment protocols of the pediatric wards of the MRRH and HICH, where the empiric treatment of meningitis is benzyl penicillin (Penicillin G) at 50,000 IU/kg every 6 hours combined with ceftriaxone at a dose of 100 mg/kg/day for 10--14 days modified according to results for culture or sensitivity. Treatment for severe malaria changed in the course of the study (September 2011) from intravenous quinine to intravenous artesunate, 3mg/kg at hour 0, 12 and 24 for a minimum of 48 hours followed by oral artesunate/lumefantrine (20/120mg) for a total of 3 days once the child can tolerate oral treatment \[[@pone.0205316.ref015]\]. There were no established hospital protocols to guide empiric treatment for bacteremia or concomitant antibiotic treatment for severe malaria. Definitions and data analysis {#sec006} ----------------------------- *Bacterial meningitis* was considered if a bacterial pathogen was detected in the CSF by culture, qPCR or Gram staining, whereas *bacteremia* was concluded if a bacterial pathogen was detected in blood but not in the CSF. *Empiric treatment* was defined as the first treatment received after admission. *Adequate treatment* was defined as treatment with antimalarial for a confirmed laboratory diagnosis of malaria and/or at least one appropriate antibiotic for bacterial infection according to the DST results (or extrapolated from overall DST results if DST results were not available for a specific isolate)--regardless of the duration of treatment and possible over-treatment. *Insufficient treatment duration* was defined as an antimalarial treatment given for less than 3 days or antibiotic treatment given for less than 5 days for bacteremia or 10 days for bacterial meningitis, or for less than the number of days of hospitalization for those who died or were discharged against medical advice before the recommended treatment duration. *Excessive treatment duration* was defined as an antimalarial given for more than 8 days or an antibiotic treatment given for more than 21 days for bacterial infections. The rationale for 21 days was to adequately treat for meningitic syndromes that require an extended treatment period such as infections resulting from *Enterobacteriaceae* or *Listeria monocytogenes*. Double data entry and data validation was done using EpiData Entry software (version 3.1, EpiData Association, Odense, Denmark) and analysis was performed using Stata (version 12, College Station, Texas, USA). Results were analyzed using descriptive statistics to obtain frequencies and proportions. Differences between groups were tested at 5% significance level. The analysis of antimicrobial treatment practices focused on children with a laboratory-confirmed malaria and/or bacterial infections with CNS involvement. Ethics {#sec007} ------ Ethical approval was obtained from Mbarara University Research and Ethics Committee (MUIRC 1/7), the Uganda National Council for Science and Technology (HS 584) and the Comité de Protection des Personnes, Ile de France XI, Saint-Germain en Laye France(reference 09013). Written informed consents for study participation were obtained from participants' parents or legal guardians. All participants were provided with treatment free of charge. The study was in accordance with the ethical standards of the Helsinki Declaration. Results {#sec008} ======= Description of the study population {#sec009} ----------------------------------- We describe results for 459 children among 480 children with suspected acute CNS infections enrolled in the study ([Fig 1](#pone.0205316.g001){ref-type="fig"}); 20 children were excluded because they were enrolled 48 hours after admission, for a diagnosis at admission different from a suspected CNS infection and one child was excluded because he had been included twice in one month. ![Study flow-chart.](pone.0205316.g001){#pone.0205316.g001} Of the 459 children with suspected acute CNS infections, 291 (63.4%) were boys. The median age was 30 months (interquartile range (IQR): 11--60). A significant proportion of children presented with reduced consciousness (71.7%) and/or seizures on admission (51.9%). Clinical characteristics at admission are presented in [Table 1](#pone.0205316.t001){ref-type="table"}. Fifty-eight (12.6%) of the children had been hospitalized elsewhere in the month before their admission, for a median duration of 2 days (IQR: 1--4). 10.1371/journal.pone.0205316.t001 ###### Socio-demographic and clinical characteristics at inclusion of patients overall, survivors and non-survivors by delay between admission and death. ![](pone.0205316.t001){#pone.0205316.t001g} Total (N = 459) Survivors (N = 376) Non-survivors \*p-value --------------------------------------- ---------------------------- --------------------- --------------- ----------- ----------- ------------- Patients characteristics Male sex 291 (63.4) 233 (62.0) 23 (71.9) 35 (68.6) 0.38 Age (months) 0.63 2--11 122 (26.6) 95 (25.3) 10 (31.3) 17 (33.3) 12--59 221 (48.2) 187 (49.7) 13 (40.6) 21 (41.2) ≥ 60 116 (25.3) 94 (25.0) 9 (28.1) 13 (25.5) HIV-positive (N = 451) 44 (9.8) 28 (7.6) 3 (9.7) 13 (26.0) **0.001** Clinical characteristics at inclusion Reduced consciousness 329 (71.7) 255 (67.8) 31 (96.9) 43 (84.3) **\<0.001** Seizures (N = 458) 238 (51.9) 192 (51.1) 21 (65.6) 25 (50.0) 0.284 Neck stiffness (N = 452) 100 (21.8) 75 (20.0) 4 (13.3) 21 (42.0) **0.002** Hepatomegaly 181 (39.4) 142 (37.8) 18 (56.3) 21 (41.2) 0.117 Splenomegaly 130 (28.3) 108 (28.7) 13 (40.6) 9 (17.7) 0.071 Respiratory distress 136 (29.6) 94 (25.0) 18 (56.3) 24 (47.1) **\<0.001** Dehydration 80 (17.4) 58 (15.4) 6 (18.8) 16 (31.4) **0.019** Abnormal lung auscultation 63 (13.7) 43 (11.4) 8 (25.0) 12 (23.5) **0.01** Delayed capillary refill 17 (3.7) 10 (2.7) 5 (15.6) 2 (3.9) **0.006** Cold extremities 20 (4.3) 12 (3.2) 4 (12.5) 4 (7.8) **0.019**   Cyanosis 4 (0.9) 2 (0.5) 1 (3.1) 1 (2.0) 0.151 \* p-value for the comparison between survivors, those who died before 48h and those who died at or after 48h. The laboratory results confirmed a diagnosis of bacterial and/or malarial infection in 219 (47.7%) children. Malaria was the only confirmed pathogen for 155 (33.8%) children, of which 109 had a clinical diagnosis of cerebral malaria, while 58 (12.6%) children were diagnosed with bacterial infections only, 47 of whom had meningitis; and 6 (1.3%) children had mixed bacterial and malarial infections. Another 17 children had a virus detected in the CSF as a potential co-infection with malaria (n = 5) or bacteria (n = 12) and are not included in the analysis of treatment adequacy due to uncertainty on the etiological agent and lack of viral treatment. Finally, 16 (3.5%) children had another type of infection (tuberculous meningitis, C*ryptococcus*, and/or viruses) and 207 (45.1%) had no laboratory-confirmed diagnosis (more details in \[[@pone.0205316.ref011]\]). Overall, 83 children (18.1%) died at the hospital. Of these, over one third (n = 32, 38.6%) died on the day of admission or the next day. There was no significant difference in the proportion who died among those hospitalized in previous month (7/58, 12.1%) and those who were not (76/401, 19.0%). Deaths within 48h of hospitalization were associated with symptoms of severe illness including loss of consciousness, respiratory distress, abnormal lung auscultation or signs of shock (cold extremities and reduced capillary refill), while later deaths were associated with neck stiffness, dehydration and HIV/AIDS ([Table 1](#pone.0205316.t001){ref-type="table"}). Case fatality was 22 (14.2%) for malaria cases, 14 (24.1%) for bacterial cases and 1 (16.7%) with both malaria and bacterial infection. Bacteria and antibiotic resistance {#sec010} ---------------------------------- Among the 64 children with bacterial infections (including mixed bacterial and malaria infections), the pathogens most frequently isolated were *Streptococcus pneumoniae*, followed by non-typhi *Salmonella* (NTS) and *Haemophilus influenzae* type b ([Table 2](#pone.0205316.t002){ref-type="table"}). Eight children had bacterial meningitis diagnosed based on Gram stain of the CSF; of these, 7 yielded Gram-positive diplococci suggestive of *S*. *pneumoniae*. 10.1371/journal.pone.0205316.t002 ###### Bacteria isolates from CSF or blood by culture and/or PCR. ![](pone.0205316.t002){#pone.0205316.t002g}   Total CSF culture & PCR CSF PCR CSF culture Blood culture only ----------------------- ------- ------------------- --------- ------------- -------------------- *S*. *pneumoniae* 34 12 15 2 5 *Salmonella* spp. 10 3 3 0 4 *S*. Typhi 3 1 0 0 2 *H*. *influenzae* 5 3 1 1 0 *E*. *coli* 2 0 0 0 2 *S*. *epidemidis* 1 0 0 0 1 *Brevibacterium* spp. 1 0 0 1 0 This table does not include 8 cases for which bacteria were observed in CSF by Gram staining Twelve enterobacteria (7 NTS, 3 *S*. *typhi*, 2 *E*. *coli*) were tested for antibiotic resistance ([Fig 1](#pone.0205316.g001){ref-type="fig"}). Except for one *E*. *coli* with extended beta-lactamase activity (ESBL), the enterobacteria were sensitive to ceftriaxone, but most were resistant to amoxicillin and cotrimoxazole and one third to gentamicin ([Fig 2](#pone.0205316.g002){ref-type="fig"}). Notably, all three *S*. *typhi* were resistant to ofloxacin. ![Proportion of sensitive, intermediate and resistant isolates among enterobacteria, *S*. *pneumoniae* and *Haemophilus influenzae* type b isolated in the study.](pone.0205316.g002){#pone.0205316.g002} All isolates of *S*. *pneumoniae* tested for antibiotic resistance were sensitive to ceftriaxone and amoxicillin, but 11/13 showed intermediate resistance to benzyl penicillin with a mean MIC of 0.34 mg/L. The 4 Hib tested for antibiotic resistance were sensitive to amoxicillin-clavulanic acid and ceftriaxone but 3 were resistant to amoxicillin. Of the 58 patients who were hospitalized in the previous month, 14 had a bacterial infection (6 *Salmonella* spp, 5 *S*. *pneumoniae*, 2 Hib, 1 *E*. *coli*) but none of these isolates were multidrug resistant. Treatments received {#sec011} ------------------- Overall, 48.1% (n = 221) of children with suspected CNS infection received antibiotics and/or antimalarial treatment within seven days prior to admission at MRRH or HICH, of whom 42 received antibiotics only, 114 received antimalarials only, and 65 received both. The proportion of patients having received any kind of medication in the seven days prior to admission was higher among children hospitalized in the previous month (77.6% vs 52.1%, p\<0.001) and this applied both to antibiotics (39.3% vs 21.5%) and to antimalarials (57.1% vs 37.0%). The main antibiotics received, alone or in combination, prior to admission were benzyl penicillin (n = 44), ceftriaxone (n = 28) and cotrimoxazole (n = 18). The main antimalarials received were quinine (intravenous n = 67, oral n = 36, or intramuscular n = 29) and artemether/lumefrantrine (n = 42). All but one child, who was rapidly referred to another hospital, received antimicrobial treatment during admission. On the day of admission, 138 (30.1%) children received both antibiotics and antimalarial, 153 (33.3%) children received antibiotics only and 106 (23.1%) antimalarial only. Within 48 hours of admission, an additional 92 children received antibiotics and 39 children received antimalarials. Among the 291 children who received empiric antibiotic treatment on the day of admission, the most common antibiotics received were ceftriaxone (n = 226, 77.7%) and benzyl penicillin (n = 212, 72.9%), usually as a combination (n = 169, 58.1%). Among those given antimalarial treatment on admission, most of the children (185/244, 75.8%) were treated with quinine, followed by artesunate (n = 51). Treatment adequacy {#sec012} ------------------ Of the 219 children with laboratory-confirmed bacterial and/or malaria infection, 182 (83.1%) received adequate treatment on the day of admission, while 211 (96.3%) received adequate treatment within 48 hours of admission ([Table 1](#pone.0205316.t001){ref-type="table"}). In total, 8 children did not receive adequate treatment within 48 hours of admission, of which two died. One child with ESBL-producing *E*. *coli* resistant to ciprofloxacin received benzyl penicillin, ceftriaxone and ciprofloxacin within 24 hours of admission but died 48 hours after admission. The other child had a mixed malarial and bacterial infection, was treated with only antimalarials and died within 24 hours of admission before blood culture result was available. There was no significant difference in the proportion of those who received adequate antimalarial or antibiotic treatment at different time points (prior to admission, on the day of admission, or within 2 days of admission) among survivors and non-survivors ([Table 3](#pone.0205316.t003){ref-type="table"}). 10.1371/journal.pone.0205316.t003 ###### Description of treatment received per type of infection and outcome. ![](pone.0205316.t003){#pone.0205316.t003g}   Survivors Non survivors p-value ------------------------------------------------- ------------- --------------- --------- **Malaria only** **N = 133** **N = 22**     Antimalarials prior admission (N = 153) 66 (51.6) 10 (45.5) 0.57     Antimalarials on admission 111 (83.5) 21 (95.5) 0.20     Antimalarials within 48h of admission 128 (96.3) 22 (100) 1 **Bacterial infection only** **N = 44** **N = 14**     Adequate treatment prior admission (N = 53) 12 (30.0) 2 (15.4) 0.47     Adequate treatment on admission 36 (81.8) 12 (85.7) 1     Adequate treatment within 48h of admission 43 (97.7) 13 (92.9) 0.43 **Mixed malaria and bacterial infection** **N = 5** **N = 1**     Adequate treatment prior admission 0 (0) 0 (0)  /     Adequate treatment on admission 2 (40.0) 0 (0) 1     Adequate treatment within 48h of admission 5 (100) 0 (0) 0.17 Treatment duration {#sec013} ------------------ Of the 161 children who had malaria (including 6 with mixed malaria and bacterial infection), 9 (5.6%) children had an insufficient duration of treatment and 17 (10.6%) an excessive duration. Among 58 children with bacterial infections only, 7 (12.1%) had an insufficient duration of treatment (5 to 8 days), while 6 (10.3%) had an excessive duration. Finally, 2 of 6 with mixed malaria and bacterial infection had an insufficient duration of treatment. Discussion {#sec014} ========== In the context of global rise in antibiotic resistance \[[@pone.0205316.ref016],[@pone.0205316.ref017]\] and the absence of microbiology capacity in most resource-limited settings (11), clinicians face uncertainty regarding the appropriateness and efficacy of empirical treatments. This study of the aetiology of CNS infections in Mbarara provided us with an opportunity to investigate the adequacy of treatment received by children admitted with bacterial or malaria infection. We found a high mortality in children, particularly among those with bacterial CNS infection, in line with other findings from Africa reporting in-hospital CRFs ranging from 9% to 67% for all types of confirmed bacterial meningitis \[[@pone.0205316.ref003]\] and from 18% to 94% for pneumococcal meningitis \[[@pone.0205316.ref018]\]. In the present study, all meningitis deaths but two had received adequate treatment within 48h of admission, suggesting that lack of adequate treatment in the hospital was not the main cause of the high mortality, while illustrating some of the main challenges for empiric treatment in these contexts: antibiotic resistance and co-infections. The levels of antibiotic resistance among isolates found in this study was relatively low, in line with Ugandan data reported in the 2014 Antimicrobial Resistance report published by WHO \[[@pone.0205316.ref017]\]. Though reduced susceptibility of *S*. *pneumoniae* to benzyl penicillin was already reported in children with pneumococcal meningitis in Uganda in 2005--2006 \[[@pone.0205316.ref019]\], no complete resistance to penicillin has been observed here or elsewhere in this area \[[@pone.0205316.ref020]\]. Given the antibiotic resistance patterns with reduced susceptibility to benzyl penicillin and presence of enterobacteria as causative agents in some children, it is reasonable to use ceftriaxone or cefotaxime as first line management for acute meningitis in this region empirically, as recommended in the Ugandan clinical guidelines \[[@pone.0205316.ref015]\]. However, one of the two children who died without receiving adequate treatment was infected with an ESBL-producing multidrug resistant *E*.*coli* isolate. This raises a concern as such infection is difficult to detect and active agents against ESBL-producing gram-negatives, such as carbapenems, were not available on site for treatment and remain largely unavailable in the African public sector. Hence, close monitoring of the possible emergence of ESBL enterobacteria is warranted. The other child who died without receiving adequate treatment had a mixed bacterial-malaria infection but was treated for malaria only. The current WHO recommendation is to administer broad-spectrum antibiotics to children with severe malaria until a bacterial infection is excluded \[[@pone.0205316.ref021]\]. However, these recommendations are debated considering the high prevalence of malaria and consequences of adding an antibiotic both in terms of cost and risk for antibiotic resistance \[[@pone.0205316.ref022]\]. It also shows the need to develop rapid tests for identifying life-threatening bacterial infections occurring with or without malaria. Although the majority of children, including those who died, had received adequate treatment within 48h of admission, the time of administration of antimicrobial treatment was not optimal for all children. The delay in initiation of treatment could be due to delay in clinical decision making by junior medical officers or drug shortages, as commonly seen in this context. Refresher training and supervision of junior health workers and nursing staff to adhere to treatment protocols could be helpful in ensuring prompt administration of antimicrobial treatment. Indeed, almost one in five children did not receive adequate treatment on the day of hospital admission. The proportions were similar in children who survived and died, suggesting no direct association with increased risk of death, however there may be other factors involved that could have obscured such a relationship. We found both insufficient duration of antibiotics in some children and excessive duration in others. Insufficient duration may place children at higher risk of death and of relapse, especially in low-resources settings where follow-up outpatient care systems are weak. Under-treatment is also a concern with pathogens that are more difficult to eradicate including *Salmonella* spp. \[[@pone.0205316.ref023]\]. Here, however, all children with insufficient duration of antibacterial treatment had received at least 5 days of treatment, which was shown to be sufficient in most cases \[[@pone.0205316.ref024]\]. Over-treatment comes with other risks including the risk to patients of prolonged hospitalization, elevated risk of treatment-related toxicity, inconvenience / loss of income for family and the potential contribution to individual and community antibiotic resistance. Non-adherence to treatment guidelines in humanitarian hospitals has been associated with poor outcomes such as death or loss to follow up in pediatric patients \[[@pone.0205316.ref025]\]. One important limitation of this study was that we did not have data on duration of symptoms prior to seeking medical care or hospitalization; delayed presentations could have resulted in increased mortality. We also did not have data on the precise time of treatment initiation upon presentation, although the majority of patients received treatment on the day of admission. Another limitation was the inclusion of children with various clinical presentations at admission and types of infections, including cerebral and non-cerebral malaria, bacterial meningitis and bacteremia with neurological symptoms, with different risks of death. However, this reflects the practical reality of clinical medicine in a pediatric hospital in Uganda. Furthermore, the categorization of treatment adequacy is challenging and we did neither consider treatment dosages nor the additional (non-antimicrobial) treatments received by the children. Finally, this study was a secondary analysis of a pre-existing cohort and may not have been adequately powered to detect differences in the outcomes of interest. Therefore, the findings should be considered to be exploratory. Despite these limitations, the data suggest that it is unlikely that the high in-hospital mortality observed in this study was due to inadequate initial antimicrobial treatment. Hence, we speculate that some of the contributing factors could have been delay in presentation from poor treatment access or late caregiver disease recognition, severity of disease or late administration of the antimicrobial on the day of admission \[[@pone.0205316.ref026]\]. This highlights the need for better recognition and management of severe febrile illnesses in the community. Given the high prevalence of bacterial meningitis among children admitted with fever and suspicion of CNS infection and local patterns of antibiotic susceptibility, the empirical use of a third-generation cephalosporin on admission appears to be justified in this setting, but the evidence of emerging resistance to cephalosporins among enterobacteria emphasizes the need for close monitoring of antibiotic resistance. Supporting information {#sec015} ====================== ###### Study dataset. All dates in the dataset were randomly modified to ensure data anonymization. (XLSX) ###### Click here for additional data file. We would like to thank all participants in the study and their parents, and the study team in the ward: Kalubi Peter, Jenifer Zungu, Dickson Tumusiime and Grace Kekirunga, Gervase Ndyanabo, Kemigisa Rose, Amerias Arimpa, Masturah Nakanwagi and Doreen Mpeirwe; and in the laboratory: Victoria Katawera, Sulaiman Muwanga, Daniel Omoding, Harriet Adrama, Thadeous Tuhuro, Arnold Ayebare, Patrick Orikiriza and Celine Gazin. [^1]: **Competing Interests:**The authors have declared that no competing interests exist.
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Effect of Adjuvant Radiotherapy on Survival in Patients with Locoregional Urothelial Malignancies of the Upper Urinary Tract. While radical nephroureterectomy is the treatment of choice for localized or regional urothelial carcinoma of the upper urinary tract (UTUC), the role of adjuvant radiotherapy is unclear, with conflicting data from various small studies. We sought to study the impact of adjuvant radiotherapy on UTUC by utilizing the Survelliance, Epidemiolgy, and End Results (SEER) 9 database from 1998-2011. Of 2,572 identified cases, 113 patients (4.4%) received adjuvant radiotherapy, with a median age of 74 years (range=22-100 years). In univariate analysis, patients treated with adjuvant radiation therapy seemed to have a lower survival time than those without radiation therapy (19 months versus 31 months, p<0.05). However, after adjusting for covariates, including age at diagnosis, gender, race, year of diagnosis, stage, histological grade and surgery, radiation therapy did not seem to influence survival (hazard ratio=0.68; 95% confidence interval=0.68-1.06, p=0.85). This hypothesis-generating, population-based analysis shows that adjuvant radiotherapy may not influence survival among patients with locoregional UTUC.
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Q: Missing return type on function - in react (typescript) code In my App.tsx i got this: Missing return type on function.eslint(@typescript-eslint/explicit-function-return-type) And in my main class component i got these: Missing accessibility modifier on method definition render.eslint(@typescript-eslint/explicit-member-accessibility) Missing return type on function.eslint(@typescript-eslint/explicit-function-return-type) I'm using React with TypeScript. For linter I use ESLint and for code formating Prettier. I found this info: https://github.com/typescript-eslint/typescript-eslint/blob/v1.6.0/packages/eslint-plugin/docs/rules/explicit-function-return-type.md , but I don't know how and where to apply it. App.tsc class Main extends Component { render() { return ( <Router> <div> <Link to="/">Home</Link> <br /> <Link to="/component1">Component1</Link> <br /> <Link to="/component2">Component2</Link> <Route exact path="/" render={() => <h1>Home Page</h1>} /> <Route path="/component1" component={Component1} /> <Route path="/component2" component={Component2} /> </div> </Router> ); } } Component1.tsc interface Props { number: number; onNumberUp: any; onNumberDown: any; } const Component1 = (props: Props): JSX.Element => { return ( <div> <h1>Component1 content</h1> <p>Number: {props.number}</p> <button onClick={props.onNumberDown}>-</button> <button onClick={props.onNumberUp}>+</button> </div> ); }; const mapStateToProps = (state: any) => { return { number: state.firstReducer.number, }; }; const mapDispachToProps = (dispach: any) => { return { onNumberUp: () => dispach({ type: 'NUMBER_UP' }), onNumberDown: () => dispach({ type: 'NUMBER_DOWN' }), }; }; Reducer and actions are in separate folders. Component1 and Component2 are similar. Does someone knows how to fix this error? A: Missing accessibility modifier on method definition render.eslint(@typescript-eslint/explicit-member-accessibility) Accessibility modifiers are things like public/private/protected. For render, this should be public. So add the word public to render(): class Main extends Component { public render() { ... } } Missing return type on function.eslint(@typescript-eslint/explicit-function-return-type) You shouldn't have that error here. This is telling you to add a return type to render, but since you've extended React.Component it should be able to load the type from the type definitions. Have you added @types/react & @types/react-dom to your project? If not, npm i -D @types/react @types/react-dom Also looks like you need @types/redux for your redux code: (npm i -D @types/redux) import { Dispatch } from 'redux'; const mapDispatchToProps = (dispatch: Dispatch<any>) => { return { onNumberUp: () => dispatch({ type: 'NUMBER_UP' }), onNumberDown: () => dispatch({ type: 'NUMBER_DOWN' }), }; }; Final note - I'm not a fan of the public/private accessor rule in ESLint. I would just disable it. More info here (point 1): https://medium.com/@martin_hotell/10-typescript-pro-tips-patterns-with-or-without-react-5799488d6680
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Drain (surgery) A surgical drain is a tube used to remove pus, blood or other fluids from a wound. They are commonly placed by surgeons or interventional radiologists. Use The routine use of drains for surgical procedures is diminishing as better radiological investigation and confidence in surgical technique have reduced their necessity. It is felt now that drains may hinder recovery by acting as an 'anchor' limiting mobility post surgery and the drain itself may allow infection into the wound. In certain situations their use is unavoidable. Drains may be hooked to wall suction, a portable suction device, or they may be left to drain naturally. Accurate recording of the volume of drainage as well as the contents is vital to ensure proper healing and monitor for excessive bleeding. Depending on the amount of drainage, a patient may have the drain in place one day to weeks. Drains will have protective dressings that will need to be changed daily/as needed. Complications Drains have a tendency to become occluded or clogged, resulting in retained fluid that can contribute to infection or other complications. Thus efforts must be made to maintain and assess patency when they are in use. Once a drain becomes clogged or occluded, it is usually removed, as it is no longer providing any benefit. Types of drains Surgical drains can be broadly classified into: Jackson-Pratt drain - consists of a perforated round or flat tube connected to a negative pressure collection device. The collection device is typically a bulb with a drainage port which can be opened to remove fluid or air. After compressing the bulb to remove fluid or air, negative pressure is created as the bulb returns to its normal shape. Blake drain - a round silicone tube with channels that carry fluid to a negative pressure collection device. Drainage is thought to be achieved by capillary action, allowing fluid to travel through the open grooves into a closed cross section, which contains the fluid and allows it to be suctioned through the tube. Penrose drain - a soft rubber tube Negative pressure wound therapy - Involves the use of enclosed foam and a suction device attached; this is one of the newer types of wound healing/drain devices which promotes faster tissue granulation, often used for large surgical/trauma/non-healing wounds. Redivac drain - a high negative pressure drain. Suction is applied through the drain to generate a vacuum and draw fluids into a bottle. Pigtail drain - has an exterior screw to release the internal "pigtail" before it can be removed Davol Chest tube - is a flexible plastic tube that is inserted through the chest wall and into the pleural space or mediastinum Wound manager See also Wound healing Incision and drainage Instruments used in general surgery References External links Category:Surgical instruments Category:Interventional radiology
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Q: What is the -t flag for pip? I was advised to use pip install module-name -t /path/to/project-dir, but I did not understand what the t flag is for. Can someone help me? A: From the manual: -t, --target <dir> Install packages into <dir>. By default this will not replace existing files/folders in <dir>. Use --upgrade to replace existing packages in <dir> with new versions.
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Flunarizine for Headache Prophylaxis in Children With Sturge-Weber Syndrome. Children with Sturge-Weber syndrome can experience severe headache with or without transient hemiparesis. Flunarizine, a calcium antagonist, has been used for migraine. The experience with flunarizine for headache in a cohort of children at a national center for Sturge-Weber syndrome is reviewed, reporting its efficacy and adverse effect in this population. We collected data from health care professionals' documentation on headache (severity, frequency, duration) before and on flunarizine in 20 children with Sturge-Weber syndrome. Adverse effects reported during flunarizine treatment were collated. The Wilcoxon signed rank test was used to determine the significance of pre- versus post-treatment effect. Flunarizine was used for headache alone (13) or mixed migrainous episodes and vascular events (7). The median duration of treatment was 145 days (range 43 to 1864 days). Flunarizine reduced headache severity (z = -3.354, P = 0.001), monthly frequency (z = -2.585, P = 0.01), and duration (z = -2.549, P = 0.01). Flunarizine was discontinued owing to intolerable adverse effects in a minority (2). Sedation and weight gain were the most common side effects. There were no reports of behavior change or extrapyramidal features. The most effective management for headaches in patients with Sturge-Weber syndrome has not been established. This retrospective observational study found benefit of flunarizine prophylaxis on headache severity, frequency, and duration in children with Sturge-Weber syndrome without severe side effects. Flunarizine is not licensed for use in the United Kingdom, but these data support its off-license specialist use for headache prophylaxis in Sturge-Weber syndrome.
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Brief vs standard hospitalization: for whom? An effort was made to determine patient characteristics that have differential prognostic significance, depending on treatment assignment to one of three treatment approaches: standard inpatient care (n = 63), brief hospitalization followed by day care (n = 61), and brief hospitalization without day care (n = 51). All were followed by outpatient care. Both demographically and clinically assessed behavioral variables were related to a number of outcome measures, including days in the community, clinical ratings, and family assessment. Generally, the standard treatment was inferior to the two brief treatments. Multiple previous admissions were particularly contraindicative for standard treatment. High overt anger score was especially contraindicative for brief hospitalization without day care and particularly indicative for brief hospitalization with day care.
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What is the long-term legacy of political persecutions? Here I want to present the main findings of my recent research with Melanie Meng Xue (UCLA Anderson). Our research is an attempt to undercover how a legacy of political persecution can shape social capital and civil society by studying imperial China. The full version of the paper is available here. We know from other research that particular institutions, policies, and events can have a detrimental and long-lasting impact on economic and political outcomes (e.g. Nunn 2011, Voigtländer and Voth, 2012). But it is hard to find a setting where we can study the long-run impact of autocratic institutions. A key feature of autocracy is the use of persecutions to intimidate potential opponents. In our paper, Melanie and I argue that the intensification of imperial autocracy that took place in the High Qing period (1680-1794) provides an ideal setting to study the impact of such persecutions. Qing China The High Qing period was one of great political stability, imperial expansion, and internal peace. Economic historians like Bin Wong and Ken Pomeranz have shown that China possessed a flourishing market economy during this period; it experienced Smithian economic growth and a massive demographic expansion. Rulers such as the Kangxi (1661-1722) and Qianlong Emperors (1735-1794) are seen as among the most successful in Chinese history. Nevertheless, as ethnic Manchus, these rulers were extremely sensitive to possible opposition from the Han Chinese. And during this period Qing tightened control over the gentry and implemented a policy of the systematic persecution of dissent. (Figure 1 depicts the Manchu conquest of China.) The Literary Inquisitions The focus of our paper is on the impact of persecutions conducted by Qing China against individuals suspected of expressing disloyalty. We study the impact of these state-orchestrated persecutions on the social fabric of society. This allows us to speak to the kinds of concerns that authors like Hannah Arendt and George Orwell expressed about the long-run impact of totalitarianism in the 20th century. These persecutions are referred to by historians as ‘literary inquisitions’. Existing scholarship suggests that the resulting fear of persecution elevated the risks facing writers and scholars, and created an atmosphere of oppression and a culture of distrust which deterred intellectuals from playing an active role in society. But these claims have never been systematically investigated. Putting together several unique datasets for historical and modern China, we explore the impact of literary inquisitions on social capital in Qing China and trace its long-run impact on modern China through its effect on cultural values. To conduct our analysis, we use data on 88 inquisition cases. We match the victims of each case (there are often multiple victims per case) to their home prefecture. This data is depicted in Figure 1. Since prefectures varied greatly in their economic, social, and political characteristics we conduct our analysis on a matched sample. This ensures that the prefectures “treated” by a literary inquisition are similar in terms of their observables to those we code as “untreated”. As our data is a panel, we are able to exploit variation across time as well as variation in space. While individuals could be persecuted for a host of reasons, these were all but impossible to anticipate ex ante. Cases were referred to the emperor himself. Frederic Wakeman called this “the institutionalization of Imperial subjectivity.” The standard punishment in such cases was death by Lingchi or (slow slicing) and the enslavement of all one’s immediate relatives. In some cases, however, the guilty party would be executed by beheading. These persecutions aimed to deter opposition to Qing rule by signaling the ability of the Emperor to hunt down all potential critics or opponents of the regime. The Impact of Literary Inquisitions on Social Capital We initially focus on the impact of persecution on the short and medium-run using our historical panel. We first examine the effects on the number of notable scholars. In our preferred specification we find that a literary inquisition reduced the number of notable scholars in a prefecture by 33 percent relative to the sample mean. We go on to show the effect of persecutions on collective participation among the gentry in China. Our measure of collective participation in civil society is the number of charitable organizations. Charitable organizations played an important role in premodern China providing disaster relief and local public goods such as repairing local roads. They were non-governmental organizations and played an important role alongside the government provision of disaster relief. In our preferred empirical specification, we find that a persecution number of charitable organizations by 38 percent relative to the sample mean. These results are in keeping with the argument that literary inquisition had a major psychological impact on Chinese society. They are consistent with the rise of “inoffensive” literary subjects during the Qing period that have documented by historians. To reduce the risk of persecution, intellectuals scrupulously avoided activities that could be interpreted as constituting an undermining of Qing rule. Instead they “immersed themselves in the non-subversive “sound learning” and engaged in textual criticism, bibliography, epigraphy, and other innocuous, purely scholarly pursuits” (Wiens, 1969, 16). The Impact of Literary Inquisitions on 20th Century Outcomes We go on to examine how the effects of these persecutions can be traced into the 20th century. In particular, we focus on the provision of basic education at the end of Qing dynasty. In late 19th and early 20th century China, there was no centralized governmental provision of primary schools. Basic education remained the responsibility of the local gentry who ran local schools. Thus the provision of education at a local level was dependent on the ability of educated individuals to coordinate in the mobilization of resources; this required both cooperation and trust. We therefore hypothesize that if the persecution of intellectuals had a detrimental impact on social capital, it should also have negatively affected the provision of basic education. We find that among individuals aged over 70 in the 1982 census – hence individuals who were born in the late Qing period – a legacy of a literary inquisition is associated with lower levels of literacy. This reflects the impact of literary inquisition on the voluntary schools provided by the gentry and is not associated with lower enrollment at middle school or high school. We show that result is robust to controlling for selective migration and for the number of death caused by the Cultural Revolution. Finally, we show that literary inquisitions generated a cultural of political non-participation. Drawing on two datasets of political attitudes – the Chinese General Social Survey (CGSS) and the Chinese Political Compass (CPoC) – we show that individuals in areas in which individuals were targeted during literary inquisitions are both less trusting of government and less interested in political participation. Finally, we find that individuals in prefectures with a legacy of literary inquisitions are less likely to agree that: “Western-style multi-party systems are not suitable for China” (Q 43.). This suggests that in areas affected by literary inquisitions individuals are also more skeptical of the claims of the Chinese government and more open to considering alternative political systems. Similarly, individuals in affected prefectures are more likely to disagree with the statement that: “Modern China needs to be guided by wisdom of Confucius/Confucian thinking.” In summary, our analysis suggests that autocratic rule reduced social capital and helped to produce a culture of political quietism in pre-modern China. This has left a legacy that persisted into the 20th century. These findings have implications for China’s current political trajectory. Some scholars anticipate China undergoing a democratic transition as it’s economy develops (Acemoglu and Robinson, 2012). Others point to China as an example of “authoritarian resilience.” By showing that a long-history of autocratic rule and political persecutions can produce a culture of political apathy, our results shed light on a further and previously under-explored source of authoritarian resilience.
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PTEN is one of the most frequently mutated genes in human cancer and the PTEN protein is considered to be a guardian of the genome because of its important role in protecting chromosomal integrity. Observation of structural chromosome aberrations and aneuploidy in cells and tissues lacking functional PTEN brings the link between PTEN and chromosome stability sharply into focus. In our recent studies, we found that cells lacking PTEN exhibit chromosome missegregation and prominent polyploidy, suggesting that PTEN functions during mitosis to control genomic and karyotypic stability. Chromosome instability acquired during aberrant mitosis plays a causative role in tumor development and progression. The long-term goal of this research project is to establish the novel concept that PTEN plays an essential part in controlling mitotic chromosome stability and that its function in maintaining mitotic fidelity is a major driving force in tumor suppression. In support of this aim, our exciting new preliminary data reveal that PTEN deficiency leads to gross genomic alterations manifested by polyploidization and confers cellular resistance to spindle perturbation. Significantly, we found that the protein phosphatase activity of PTEN is required for maintenance of a normal karyotype, and for cellular sensitivity to spindle drugs. In addition, our data have revealed that a key mitotic kinase, polo-like kinase 1 (Plk1), is a potential PTEN target. These findings lead to our hypothesis that PTEN is required for ensuring faithful chromosome inheritance during mitosis and that the protein phosphatase function of PTEN is critical for restraining aberrant mitotic kinase activity in order to maintain a normal karyotype. To test this hypothesis, we propose two specific aims as follows. In Aim 1, we will demonstrate mitotic chromosome instability is a prevailing phenotypic consequence of PTEN deficiency. We will use a Pten conditional knockout leukemia animal model and a panel of Cowden syndrome-derived human lymphoblastoid cell lines to validate the potential causative relationship between PTEN deficiency and karyotypic alterations. In Aim 2, we will define the inhibitory signaling link between PTEN and Plk1 and elucidate the mechanism by which their balanced interplay contributes to karyotypic fidelity and tumor suppression. Using cellular and molecular biology approaches, we will characterize PTEN as an essential mitotic phosphatase and demonstrate that Plk1 is a protein target of the PTEN phosphatase that maintains mitotic chromosome stability. Successful completion of these aims will provide insight into the mechanisms whereby PTEN deficiency triggers mitotic defects and chromosomal instability, and thus leads to tumorigenesis. New findings from this project will offer a new perspective for further mechanistic studies and future development of therapeutic strategies in treating human cancers. PUBLIC HEALTH RELEVANCE: PTEN phosphatase is a potent tumor suppressor that is known to antagonize oncogenic pathways. This project will characterize a new function of PTEN in controlling cell division and identify Plk1 as a nuclear target of PTEN phosphatase that maintains mitotic fidelity and karyotypic stability. New findings from this study will elucidate how the novel PTEN-Plk1 signaling pathway prevents genomic instability and tumorigenesis, providing significant implications for development of new anti-cancer strategies.
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State Correctional Institution – Greene SCI Greene is a maximum security prison, classified as a Supermax, located in Franklin Township, Greene County, Pennsylvania, near Waynesburg, off Interstate 79 and Pennsylvania Route 21. Pennsylvania Department of Corrections operates the prison, which houses most of Pennsylvania's capital case inmates. It is in the far southwest of the state, near the border with West Virginia, in a rural area. History SCI Greene opened in late 1993. Around 1996, some prisoners stated that some guards used more force than necessary to control them, and a video camera had captured evidence related to the complaint. Charles Graner, a prison guard who began working at SCI Greene in 1996, was the defendant in two lawsuits, each by a different prisoner; both lawsuits were dismissed as one disappeared after finishing his sentence and the other had submitted his lawsuit after a deadline. Graner later became known for the Abu Ghraib scandal. Facility and operations The prison had 11 cell blocks. SCI Greene had 1,750 prisoners and 720 employees. The death row prisoners are in blocks G and L; they normally stay in their cells but may go to a recreational area and the library. Greene was built with the newest features at the time, including central air conditioning. The prison had cable television installed at the time of its opening. Demographics , SCI Greene had 157 death row prisoners, about 75% of the prisoners under Pennsylvania state death sentences. As of the late 1990s, many of the prisoners came from urban areas and almost 70% were black, while whites made up over 90% of the prison guards. Notable inmates Life imprisonment: Ben Birdwell, convicted in the Freeman family murders Domenic Coia, convicted in the murder of Jason Sweeney Juan Covington, Philadelphia serial killer Russell Maroon Shoatz, convicted in the murder of Police sergeant Francis Von Colln. Founder of Black United Movement in Philadelphia; former member of the Black Panther Party and the Black Liberation Army Other imprisonment Khalid Kareem (alias S Money), Pittsburgh rapper sentenced to five years in federal prison in 2014 for his role in a heroin ring now at FCI Berkley Jerry Sandusky Death row: Aaron Jones, leader and co-founder of the Philadelphia drug gang J.B.M (Junior Black Mafia) Christopher Roney (alias Cool C), hip hop artist, convicted in the murder of Philadelphia Police Department officer Lauretha Vaird in a bank robbery Eric Frein, killed a police officer and was on the FBI Ten Most Wanted Fugitives list in 2014. Harvey Miguel Robinson, serial killer moved to State Correctional Institution – Phoenix in 2018. Notable staff Charles Graner (began in 1996, later became an Abu Ghraib prison guard) See also List of Pennsylvania state prisons References External links "SCI Greene." Pennsylvania Department of Corrections. Abuses at SCI Greene SuperMax http://articles.mcall.com/2012-08-04/news/mc-pennsylvania-death-row-tour-20120804_1_solitary-confinement-junius-burno-death-row Greene Greene Category:Buildings and structures in Greene County, Pennsylvania Category:1993 establishments in Pennsylvania
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Piracy incidents against ships in Asia drops to only three in November 17.12.2018 There were only three incidents of piracy and armed robbery against ships in Asia in November, according to data from Regional Cooperation Agreement on Combating Piracy and Armed Robbery against Ships in Asia (ReCAAP), reported Shipping Gazette.One was a piracy incident that occurred on board a ship while underway in the South China Sea, and two were armed robberies against ships anchored/ berthed at Tabangao anchorage area, Batangas Bay, Philippines.ReCAAP said the abduction of crew for ransom in the Sulu-Celebes Seas and waters off eastern Sabah remains a serious concern.Compared to the preceding month of October, the number of incidents reported in November has decreased from six in October to three in November.In the first 11 months of the year there was a total of 73 reported incidents, comprising 59 actual incidents and 14 attempted incidents. Of the 73 incidents, 69 were incidents of armed robbery against ships and four were piracy incidents.Compared to January-November 2017, there was a 15 per cent decrease in the total number of reported incidents during the same period this year.The total number of actual incidents reported during January-November 2018 was the lowest among the 10-year reporting period of January-November 2009-2017.With regards to the situation in Sulu-Celebes Seas and waters off eastern Sabah, there were no reports of actual or attempted incidents involving the abduction of crew from ships while underway in these waters this November.The last attempted incident occurred to containership, Kudos 1 while sailing off Sibago islands, Basilan, Philippines on February 16.On October 30, ReCAAP ISC issued a warning about Abu Sayyaf group members planning to conduct kidnapping activities at any opportune time in undisclosed areas in Sabah.
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Back pain can be caused by a variety of factors, including, but not limited to the rupture or degeneration of one or more intervertebral discs due to degenerative disk disease, spondylolisthesis, deformative disorders, trauma, tumors and the like. In such causes, pain typically results from compression or irritation of spinal nerve roots by reduced spacing between adjacent vertebrae, a damaged disk and/or misalignment of the spine resulting of the injury or degeneration. Common forms of treating such pain include various types of surgical procedures in which a damaged disk may be partially or totally excised, and one or more implants is inserted between adjacent vertebrae in an effort to restore the natural spacing and alignment between the vertebrae that existed previous to the injury or degeneration, so as to relieve the compression, irritation or pressure on the spinal nerve or nerves and thereby eliminate or significantly reduce the pain that the patient is experiencing. Typically, the one or more implants are used together with substances to encourage bone ingrowth to facilitate fusion between the adjacent vertebrae. Some procedures provide implants that allow at least some limited motion between the adjacent vertebrae, even after opposite ends of the implant are fixed to the adjacent vertebrae, respectively. Among know procedures for performing fusion are PLIF (posterior lumbar interbody fusion), ALIF (anterior lumbar interbody fusion) and TLIF (transverse or transforaminal lumbar interbody fusion). A PLIF procedure achieves spinal fusion in the low back by inserting an implant such as a cage and, typically, graft material (to encourage bone ingrowth) directly into the disc space between adjacent vertebrae. The surgical approach for PLIF is from the back of the patient, posterior to the spinal column. An ALIF procedure is similar to the PLIF procedure), except that in the ALIF procedure, the disc space is fused by approaching the spine through the abdomen, from an anterior approach, instead of through the lower back, from a posterior approach. Although previously there was a lot of interest in perfecting an endoscopic approach for ALIF surgery, it has largely been abandoned because it placed the great vessels (aorta and vena cava) at too great a risk. A TLIF procedure involves a posterior and lateral approach to the disc space. To gain access to the disc space, the facet joint may be removed whereby access is gained via the nerve foramen. Typically only a single implant is placed in a TLIF procedure. The implant is inserted from a postero-lateral approach, as noted, and is ultimately placed in the middle-to-anterior aspect of the disc space. There are certain conditions where a unilateral PLIF procedure is superior to a TLIF procedure. Such conditions include those where sever spinal stenosis is present. PLIF procedures typically place a pair of implants, one on each side of the disc space. To accomplish this, a typical approach forms two access ports into the disc space, both posterior to the spinal column, with one port one side relative to midline (the spinal process) and the other on the opposite side, relative to midline. Using this approach, each implant can be delivered and placed along a substantially direct delivery pathway. However, because two ports are formed, this results in a relatively large amount of removal of tissues, and risks nerve damage on both sides of the spinal column. Alternatively, both implants may be delivered using a unilateral PLIF technique in which only one port is formed on one side of the midline, posterior spinal column. This significantly reduces the amount of tissues that need to be removed and reduces the number of nerves at risk of being damaged by the procedure by half. A unilateral PLIF procedure requires the first implant, after being inserted into the disc space, to be laterally driven over the midline of the intervertebral disc space and into position in the opposite side of the disc space. Drawbacks to current procedures include difficulties in laterally driving the first implant from one side of the disc space to the other. During this process, when using an implant/cage that has substantially equal heights on both sides of the implant/cage the leading side of the implant often resists moving in the transverse direction towards the opposite side of the disc space, and may dig into the annulus fibrosus and resist transverse driving of the implant. Moreover, the use of standard instruments such as cage inserters, end impactors, curved curettes, curved chisels, etc. often result in breaking the implant, when used to try to drive the implant from one side of the disc space to the other. This poses a serious risk of nerve root injury and/or injury to other body structures when an instrument breaks or a cage breaks, or during the process of removing a broken cage. Additionally, there are cases were a broken cage is unable to be completely removed and this compromises a successful fusion outcome. The use of two implants in a PLIF procedure as opposed to the use of one implant, such as in a TLIF procedure, has been noted to markedly improve interbody fusion. However, it would be further advantageous to fusion resulting from a two implant procedure if the implants could be further laterally spaced from the midline of the intervertebral disc space, compared to current two implant procedures, as this would further enhance a honeycomb formation of fusion. There is a continuing need for implants, instruments and procedures for performing unilateral PLIF to facilitate safer and easier delivery of the first implant form one side of the disc space to the opposite side. There is a continuing need to implants instruments and procedures designed to permit placement of the implants further laterally from the midline of the intervertebral space than is possible using current implants, tools and procedures. The present invention meets at least all of the above needs.
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Central Adaptation following Brachial Plexus Injury. Brachial plexus trauma (BPT) often affects young patients and may result in lasting functional deficits. Standard care following BPT involves monitoring for clinical and electrophysiological evidence of muscle reinnervation, with surgical treatment decisions based on the presence or absence of spontaneous recovery. Data are emerging to suggest that central and peripheral adaptation may play a role in recovery following BPT. The present review highlights adaptive and maladaptive mechanisms of central and peripheral nervous system changes following BPT that may contribute to functional outcomes. Rehabilitation and other treatment strategies that harness or modulate these intrinsic adaptive mechanisms may improve functional outcomes following BPT.
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Surgical audit in the developing countries. Audit assures provision of good quality health service at affordable cost. To be complete therefore, surgical practice in the young developing countries, as elsewhere, must incorporate auditing. Peculiarities of the developing countries and insufficient understanding of auditing may be, however, responsible for its been little practised. This article, therefore, reviews the objectives, the commonly evaluated aspects, and the method of audit, and includes a simple model of audit cycle. It is hoped that it will kindle the idea of regular practice of quality assurance by surgeons working in the young developing nations and engender a sustainable interest.
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If I could choose the way I die, death by Hello Kitty swallowfacation would be up there in my top five. I used to have a Hello Kitty themed bathroom. No pics because that was, pffff, at least four years ago. A lifetime ago. And I had this humidifier up until last year. I stole it for $10 in an impulsive moving out garage sale. Ah well. Who did the last one? It exudes (yes I said that, so anyone other than Imke can ostracize me for saying 'exudes')...that is a very nice illustration. Reminds me of some old school Art Nouveau...but with a modern twist? My wedding shower is this Sunday, and I'm wearing a white eyelet fitted knee length sundress with spaghetti straps. I can't decide what kind of shoes to wear. I don't want to wear anything too dark, but I'm having trouble finding the right style. Definitely need to wear some sort of sandal. I have shoes almost identical to these: But they seem a little harsh in contrast to the delicate style of the dress. Any suggestions? Totally go for that colour! Maybe you could post a picture of the dress? But I still think the contrast is what will make it look awesome. Inspiration: Big shoes go with diaphanous dresses. Thank Chloe. Okay, good, thank you! I really don't wear a lot of accessories as it is...I always have on my engagement ring and some little platinum/diamond studs but that's it(I never even take those out of my earlobes...they're really little, like 1/4 c. each, I'd say). I don't think I'll even wear a necklace. My hair is so long that if I wear any kind of necklace, it has to be something very delicate, otherwise there's just too much going on at my neck/shoulder level and it looks junky. Important Disclaimer: Although this is Chuck Palahniuk’s official website, we are in essence, more an official ‘fansite.’ Chuck Palahniuk himself does not own nor run this website. Nor did he create it. It was started by Dennis Widmyer, who is the webmaster and editor of most of the content. Chuck Palahniuk himself should not be held accountable nor liable for any of the content posted on this website. The opinions expressed in the news updates, content pages and message boards are not the opinions of Chuck Palahniuk nor his publishers. If you are trying to contact Chuck Palahniuk, sending emails to this website will not get you there. You should instead, take the more professional route of contacting his publicist at Doubleday.
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Xanthophyll-induced aggregation of LHCII as a switch between light-harvesting and energy dissipation systems. The xanthophyll cycle pigments, violaxanthin and zeaxanthin, present outside the light-harvesting pigment-protein complexes of Photosystem II (LHCII) considerably enhance specific aggregation of proteins as revealed by analysis of the 77 K chlorophyll a fluorescence emission spectra. Analysis of the infrared absorption spectra in the Amide I region shows that the aggregation is associated with formation of intermolecular hydrogen bonding between the alpha helices of neighboring complexes. The aggregation gives rise to new electronic energy levels, in the Soret region (530 nm) and corresponding to the Q spectral region (691 nm), as revealed by analysis of the resonance light scattering spectra. New electronic energy levels are interpreted in terms of exciton coupling of protein-bound photosynthetic pigments. The energy of the Q excitonic level of chlorophyll is not high enough to drive the light reactions of Photosystem II but better suited to transfer excitation energy to Photosystem I, which creates favourable energetic conditions for the state I-state II transition. The lack of fluorescence emission from this energy level, at physiological temperatures, is indicative of either very high thermal energy conversion rate or efficient excitation quenching by carotenoids. Chlorophyll a fluorescence was quenched up to 61% and 34% in the zeaxanthin- and violaxanthin-containing samples, respectively, as compared to pure LHCII. Enhanced aggregation of LHCII, observed in the presence of the xanthophyll cycle pigments, is discussed in terms of the switch between light-harvesting and energy dissipation systems.
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Looking for a house cleaner in Little Gransden? If you're in need of a helping hand with your housework in Little Gransden, then look no further than Maid2Clean! We are the recommended house cleaning company in the local area due to our affordable rates and high quality cleaning. Get in touch today for more information, or to make a booking. A free quote can be provided within minutes! 94% of Clients Recommend Our Service Based on 992 reviews from Trustpilot Get in touch on 0800 193 0436 for a quick chat with our friendly staff! How much does domestic cleaning cost? Regular house cleaning services - from just £12.00 per hour Our regular cleans are charged per hour, all inclusive with no hidden charges! This hourly rate covers the cleaner's fee, agency fee and the necessary insurance for the cleaner to work in your home. Offered on a weekly or fortnightly basis, the same cleaner will arrive each time, for a service which can be tailored to your needs as often as necessary. Ironing can even be incorporated at no extra cost! Meet with your cleaner before any work commences, to ensure you are perfectly happy with the person due to work in your home. There is no need to agree to the first person you meet with, and you can request a change of cleaner, should you need to. This service is great for those times where you need a deep clean and quickly! The cost for this is a one off agency fee plus an hourly cleaner's rate, and is dependent on the area of the property and how many hours you need. The cleaner can work for up to 6 hours in one day, ensuring your home is left in pristine condition. If you have any specific requirements, don't hesitate to get in touch! Take a look at our helpful cleaning tips to keep your house in top condition. Reliable home cleaning from Maid2Clean Maid2Clean's domestic cleaners are happy to tackle all manner of cleaning chores such as: Furniture Floors & Carpets Kitchen Units & Worktops Bathrooms & Lavatories Vacuuming & Dusting Oven & Cooker Hood Internal Windows Ironing Any reasonable cleaning task required! We are the professional company to speak to when you want the best house cleaning in Little Gransden.
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Adult age differences in forgetting sentences. Age comparisons of performance-based measures of forgetting were carried out. In Exp. 1, 18- to 21-year-olds and 55- to 64-year-olds (n = 24) forgot at an equal rate when compared at 30 s and at 3, 6, and 24 hr after acquisition. In Exp. 2, 17- to 21-year-olds and 65- to 74-year-olds (n = 24) were compared at the same 4 retention intervals. Initial learning was equated for the 2 groups. There was evidence for an age difference in forgetting rate in cued recall when a minimal learning level was required. In Exp. 3, 440 men and women 17 to 74 years old were assigned to a retention interval from 10 min to 7 hr. Age was related to 4 performance-based measures of forgetting rate. Although the age differences were small, they imply 2 decremental processes: 1 before 10 min, possibly a result of incomplete consolidation, and a later 1 that is continuously and cumulatively operative thereafter. Evidence relating initial level to forgetting rate is presented.
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Q: sql in php not returning anything How do I see what is returned from a sql statement in php? I have the following function to get user name from mysql database and I use echo in another php to see the result but nothing shown. function get_user_name($id_user) { return mysql_result(mysql_query("SELECT username FROM user WHERE id_user = '$id_user'")); } echo $id_user; $a = get_user_name($id_user); echo $a; Can anyone help? Thanks. A: Are you echoing the get_user_name(); function?? OR are you even connected to your database? these are two things you need to check before, (if the problem remains) including an error handling method i.e. or die(mysql_error()) at the end of your query to find out the problem. return mysql_result(mysql_query("SELECT id_user FROM user WHERE id_user = '$id_user'")or die (mysql_error())); The error handling construct?? in mysql mysql_error() should output the problem in fairly understandable way, as to what is preventing your query not to be shown
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The Law Office of Joshua Coffman is excited to announce that Super Lawyers selected attorney Joshua Coffman as a 2016 Texas Super Lawyer Rising Star. This is Joshua’s third year in a row to be recognized as a Rising Star attorney. Super Lawyers is a “research-driven, peer-influenced rating service of outstanding lawyers who have attained a high degree of peer recognition and professional achievement.” Super Lawyers’ mission is to “provide visibility to attorneys who exhibit excellence in the practice of law.” Joshua is thankful for the support of his outstanding paralegal Nancy Coffman, family, friends, and loyal clients who all helped to make this recognition possible. To see this year’s list of Super Lawyer Rising Stars, pick up a copy of the April edition of Texas Monthly magazine. The Law Office of Joshua Coffman is excited to announce that Super Lawyers selected attorney Joshua Coffman as a 2015 Texas Super Lawyer Rising Star. Joshua was also recognized as a Rising Star in 2014. Super Lawyers is a “research-driven, peer-influenced rating service of outstanding lawyers who have attained a high degree of peer recognition and professional achievement.” Super Lawyers’ mission is to “provide visibility to attorneys who exhibit excellence in the practice of law.” Joshua is thankful for the support of his paralegal Nancy Coffman, family, friends, and loyal clients who all helped to make this recognition possible. To see this year’s list of Super Lawyer Rising Stars, pick up a copy of the April edition of Texas Monthly magazine.
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Q: Ranking in Excel, when I want the top n I get the top n+1 (or n+x) I have a list in excel and I'd like it to select the higher 3 results, and only 3. It seems easy to do with conditional formatting in this example: 1 | 2 | 3 | 4 | 5 | 6 44 | 78 | 98 | 45 | 52 | 98 Where the 2nd, 3rd and 6th number will be highlighted. The problem appears with something like this: 1 | 2 | 3 | 4 | 5 | 6 44 | 78 | 78 | 45 | 87 | 98 Excel will highlight the 2nd, 3rd, 5th and 6th number, because the first two (the third on a sorted list) are equal. How can I make Excel select only one of them? (the solution doesn't need to use conditional formatting, any tools available on Excel can be used, from formulas to VB, but simplicity it's desirable). A: for your conditional formatting, we need to break the tie. One way to do this is to count the number of times a value appears in the previous comparisons. This would change your conditional formula to =(RANK(A2,$A$2:$F$2)+COUNTIF($A$2:A$2,A2)-1)<=3 Note that absolute positions are used in some cases, and relative in others. Breakdown: RANK(A2,$A$2:$F$2) - Rank formula. You know this one, as you're using it now COUNTIF($A$2:A$2,A2) - count the number of times the value appears - note that the reference does not have a $ in front of the A after the colon - this is to ensure that the range gets bigger as we process the formula along the row (1st count: A2:A2, 2nd count: A2:B2, etc) -1 - as the count will always match one number (itself) so, for your second example, 44 78 78 45 87 98 The new ranks are 6 3 4 5 2 1 and the formulas convert to =RANK(A2,$A$2:$F$2)+COUNTIF($A$2:A$2,A2)-1 =RANK(B2,$A$2:$F$2)+COUNTIF($A$2:B$2,B2)-1 =RANK(C2,$A$2:$F$2)+COUNTIF($A$2:C$2,C2)-1 =RANK(D2,$A$2:$F$2)+COUNTIF($A$2:D$2,D2)-1 =RANK(E2,$A$2:$F$2)+COUNTIF($A$2:E$2,E2)-1 =RANK(F2,$A$2:$F$2)+COUNTIF($A$2:F$2,F2)-1 for the conditional formatting
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For most humans, life on the jagged Farallon Islands off the coast of San Francisco would be a nightmare: Waves lash the shore with treacherous force, the stench of guano fills the air, and the screech of seagulls is so loud that resident scientists wear earplugs to bed. But wildlife thrive on “the Devil’s Teeth” — the name given to the Farallon Islands by sailors over a century ago. The islands boast one of the world’s largest breeding colonies for seabirds, including the rare ashy storm-petrel, and their beaches are covered with lolling sea lions and seals. The waters surrounding the islands teem with 18 species of whales and dolphins. The islands also host tens of thousands of house mice — an invasive species that is wreaking havoc on the native ecosystem, according to biologists. The explosive growth in mice has attracted burrowing owls, who not only eat the mice but also prey upon the storm-petrels, a rare bird with a declining population. The federal government contends that the only way to get rid of the mice is to drop 1.5 tons of rat poison pellets from a helicopter onto the islands. But Bay Area conservationists are worried that the poison, an increasingly controversial rodenticide called brodifacoum, will kill other species and make its way up the food chain. “This is a case of using a shotgun to go after an ant,” said Richard Charter of the Ocean Foundation, one of the plan’s fiercest opponents. The U.S. Fish and Wildlife Service, the agency that manages the Farallones, acknowledges that while some non-target species will likely be killed in the process, broadcasting poison over the islands is a tried-and-true method of tackling rodent infestations. Biologists say that the long-term benefits will far outweigh any collateral damage. “If we didn’t believe this option was going to dramatically benefit the islands, and safely and effectively, we wouldn’t be recommending it,” said Doug Cordell, spokesman for the Fish and Wildlife Service. The issue is expected to come to a head on Wednesday, when the California Coastal Commission holds a public hearing on the plan. The FWS published a final environmental impact statement in March, a 300-page document more than a decade in the making. Since its draft was published in 2013, more than 34,000 people have signed a Change.org petition objecting to the proposal. Santa Cruz County Supervisor Ryan Coonerty has also spoken out against the plan and urged the Coastal Commission to oppose it. The commission’s staff, however, released a report expressing its support for the project, saying it was consistent with the state’s marine protection and water quality policies. Critics insist there is reason to be wary of brodifacoum, an anticoagulant that causes internal bleeding. Mountain lions in California have been found dead with the rodenticide in their systems after eating small prey that ingested the poison. California outlawed consumer use of the poison in 2014. And a bill that would ban the use of second-generation anticoagulants like brodifacoum on state-owned lands is making its way through the California legislature. The law would not affect federal lands like the Farallones, however. The Farallones rodenticide drop would occur in the late fall of 2020 at the earliest, and would require approval by the Environmental Protection Agency and the National Oceanic and Atmospheric Administration. The mice are a food source for migratory burrowing owls, according to biologists. But when the mouse population crashes in the winter, the owls prey on the ashy storm-petrel, whose population on the islands — where half the world’s storm petrels nest — has been declining since the ’90s. The mice have also spread invasive plant species that crowd out native vegetation. They also feed on the Farallon camel cricket and compete for food with the Farallon arboreal salamander. At peak season, there are nearly 500 mice per acre on the South Farallon Islands — about 59,000 in all. Critics do not refute that the mice need to go. But they do not buy the federal government’s insistence that rodenticide is the best way to get the job done. The Fish and Wildlife Service said it looked at dozens of eradication methods, including mouse fertility control, but ultimately found that poison was the best approach because of its proven efficacy. The agency notes that 28 out of 30 mouse eradication projects undertaken worldwide since 2007 have been successful, and that native species in those places have flourished. The Farallon Islands have suffered a long history of human interference and exploitation. In the early 1800s, Russian fur traders harvested blubber from elephant seals and pelts from sea lions. A few decades later during the Gold Rush, when the mice were likely introduced, the new residents of San Francisco needed eggs. So they raided the nests of murres, whose population dropped drastically. The species has seen a revival in recent decades. And between 1946 and 1970, government and private research agencies dumped thousands of 55-gallon drums of low-level radioactive waste into the Gulf of the Farallones. The islands now benefit from several layers of protective status. The Farallones were named a national wildlife refuge in 1909 and the waters around them are also part of the Farallones National Marine Sanctuary. The islands are off-limits to the public. Supporters of the mouse eradication project say that getting rid of the rodents is an essential step in fully restoring island ecology to the way it was before humans discovered it. And there is a certain urgency to removing the mice, according to Pete Warzybok, a biologist who for the past 20 years has lived part time on the Farallones studying ecosystem conservation. “We don’t want to wait so long that storm petrels are declining to the point that one fantastic event, like an oil spill or a bad winter season, would knock out the entire population,” Warzybok said. Critics point to the Fish and Wildlife Service’s 2008 rodent eradication project on Alaska’s Rat Island, where the same poison killed 46 bald eagles. The agency said it learned from its mistakes and has incorporated extra safeguards into the Farallones plan. The poison pellets would be dropped by helicopters twice over the span of three weeks, according to the plan. Until risk of poison exposure drops, Fish and Wildlife would scare away seagulls — the species most likely to eat the poisoned mice — using fireworks, predator calls and air cannons, a technique the agency calls “hazing” and has been tested on the islands. Raptors such as owls and hawks that might eat the poisoned mice would be temporarily removed from the sanctuary until risk of poison exposure drops. The potential risk to marine life is low, according to Fish and Wildlife. Seals won’t eat the poison, and any bait that falls into the water will “dissolve quickly or sink to the bottom,” said Cordell, the agency spokesman. Mouse carcasses will be collected by hand, although Fish and Wildlife acknowledges it could not find every dead animal and that some gulls will probably die after eating the rodents. They estimate that fewer than 1,700 gulls will die. More than that number would affect the local gull population over a 20-year span, according to biologists. Critics balk at the idea that gulls, known for their persistence and willingness to eat just about anything, will be deterred by pyrotechnics. They worry that dosed gulls will travel to mainland areas like Point Reyes National Seashore and San Francisco’s Fisherman’s Wharf, where they are known to fly. It’s there that a gull could die and be eaten by a raccoon, which could then become mountain lion prey, said Charter, an advocate for ocean protection issues. “The fear is using a method that poisons the entire food chain and hurts a lot of animals we care about deeply,” Charter said. Alison Hermance, director of communications at Wildcare, a wildlife hospital in San Rafael, has seen firsthand how rat poison has affected local species. The organization began testing livers of patients — hawks, owls, foxes, coyotes — about 10 years ago for brodifacoum. They found that 76% of the 600 animals had been exposed to the poison. “People don’t recognize that this is a much bigger issue,” said Hermance, who called the Farallones poison plan “ludicrous.” Not all animals exposed to brodifacoum die. But research shows that carrying even small amounts of the toxin in their tissue may compromise health. A 2018 study by UCLA and the National Park system found that exposure to the rodenticide appeared to weaken bobcats’ immune systems. But scientists say it is unlikely that poison from the Farallones would affect many animals on the mainland. Gulls that eat the dead mice or the poison bait would probably be too sick to fly great distances, according to Hillary Young, a professor of ecology at UC Santa Barbara who has studied other rodent eradication projects. And gulls, which prefer to fly with empty bellies, would have to eat a lot of the poison for it to kill the next animal in the food chain. Young said rodent eradication is “one of the few conservation tools in our toolbox that works for a sustained period of time.” However, she said she recognizes that the death of non-target animals triggers an emotional response. She said that even in the “worst-case scenario” of Rat Island, the native habitat there is now thriving. “All the costs are front-loaded,” Young said. “You have to wait for the benefits.”
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IMF Managing Director Christine Lagarde says she has been assured by President Cyril Ramaphosa that the country’s economy is improving. PRETORIA - International Monetary Fund (IMF) managing director Christine Lagarde has shot down any speculation that she is in the country to offer financial assistance. This comes as President Cyril Ramaphosa is trying to woo international institutions to invest billions in South Africa’s economy over the next five years. Lagarde held a media briefing in Pretoria with Reserve Bank Governor Lesetja Kganyago on Wednesday afternoon. As Ramaphosa looks to attract over $100 billion into the economy in the next five years, he won’t be seeing a cent from the IMF. Lagarde says a loan to South Africa is currently not on the cards. “And I’m confident that President Ramaphosa has his eyes on the right objectives and is very focused on what he wants to develop for the country, together with his team.” Lagarde is currently on her bi-annual African economies tour. #ReserveIMF International Monetary Fund Christine Lagarde and Reserve Bank head Lesetja Kganyago. BD pic.twitter.com/b0dIwyefj3 — EWN Reporter (@ewnreporter) December 19, 2018 Asked if the IMF would assist Eskom if approached, Lagarde said: “Easy, the answer is no, absolutely not. Because we only deal with members and no private or public company as part of the IMF.” Lagarde says she has been assured by the president that the country’s economy is improving. IMPORTANT TO ROOT OUT CORRUPTION She says she has been assured by Ramaphosa's administration that the country is working hard to root out corruption. Lagarde says the public purse needs to be used to benefit the programmes for which it has been earmarked to in order to stimulate growth. The IMF boss says she understands the country’s position on land expropriation without compensation. “…How to make that principal effective, practical, reasonably well accepted despite the difficulty of those who will eventually have to relinquish some of their current title assets.” Lagarde also touched on the Zondo Commission of Inquiry into state capture. She says it is important that corruption is rooted out and that public confidence is restored in public institutions. “It is critically important to have institutions that are strong, have depth and determination to actually conduct that kind of exercise; eliminating leakages.” Lagarde says the IMF will monitor South Africa efforts to rehabilitate the economy. (Edited by Mihlali Ntsabo)
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Scrapino – Self-sustainable robot from e-scrap using renewable energy [pdf] - watchdogtimer https://www.sciencedirect.com/science/article/pii/S2405896318328593/pdf?md5=ac7fae174710da0a5035026f88e0559b&pid=1-s2.0-S2405896318328593-main.pdf ====== TeMPOraL How is this a paper? TL;DR: \- Industrial robots are important and also expensive. \- Wouldn't it be cool if they were made from e-scrap? We suggest attaching a solar panel for extra joy! \- <Bunch of buzzwords around learning and community and end-of-life management.> \- Look at those toy robots made from scrap! (And look, there's also a Dalek that can poop!) \- Let's do what every hobbyist in every hackerspace has been doing daily for near a decade now: take an Arduino, a bunch of random leftover components, and make a "robot" with servos and ultrasound range finders. \- Conclusion: (industrial) robots are important and expensive, but our (Arduino kitbashing) robot shows the way for building them in a more responsible fashion. It also shows how a bottom-up approach to e-scrap could work. Add spelling & formatting errors to the mix. Flagged for extremely low SNR. ~~~ bArray Agreed. This method of sustainable robots is generally not very good en mass. It's good for a hackaday post, but try making 100 of these. Before this is a possibility, we need robots that are able to self-model and hence understand the relationship between sensors and actuators correctly. Even 3D printing a robot on the same 3D printer, with the same calibrated parts from manufacturers, with the same software - _still_ requires calibration. The more complicated the robot, the more the errors accumulate. As for the quality of the paper - I completely blame the journal (who are ultimately responsible for the actions of the reviewers) as this should have been caught earlier. I can understand authors rushing to produce a paper not in their own language, but the profit machine journals need to take more responsibility for what they publish.
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1. Field of the Invention The invention relates to polymeric viscosity index (V.I.) improvers--dispersant additives for petroleum oils, particularly lubricating oils. These additives comprise a copolymer of ethylene with one or more C.sub.3 to C.sub.28 alpha-olefins, preferably propylene, which have been grafted with acid moieties, e.g. maleic anhydride, preferably using a free radical initiator, in a solvent, preferably lubricating oil, and then reacted with a mixture of an acid component, preferably an alkenyl succinic anhydride, and a polyamine having two or more primary amine groups. Or the grafted polymer may be reacted with said acid component prereacted with said polyamine to form salts, amides, imides, etc. and then reacted with said grafted olefin polymer. The invention also relates to processes for preparing the preceding products, their use in oil compositions, and includes an improved solution process for grafting acid moieties, e.g. maleic anhydride, onto the ethylene copolymer by staged, or continuous, addition of maleic anhydride and initiator to thereby carry out the graft reaction in the solution stage permitting a high level of grafting while minimizing side reactions. 2. Prior Disclosures The concept of derivatizing V.I. improving high molecular weight ethylene copolymers, with acid moieties such as maleic anhydride, followed by reaction with an amine to form a V.I.-dispersant oil additive is known in the art as indicated by the following patents. U.S. Pat. No. 3,316,177 teaches ethylene copolymers such as ethylene-propylene, or ethylene-propylene-diene, which are heated to elevated temperatures in the presence of oxygen so as to oxidize the polymer and cause its reaction with maleic anhydride which is present during the oxidation. The resulting polymer can then be reacted with alkylene polyamines. U.S. Pat. No. 3,326,804 teaches reacting ethylene copolymers with oxygen or ozone, to form a hydroperoxidized polymer, which is grafted with maleic anhydride followed by reaction with polyalkylene polyamines. U.S. Pat. No. 4,089,794 teaches grafting the ethylene copolymer with maleic anhydride using peroxide in a lubricating oil solution, wherein the grafting is preferably carried out under nitrogen, followed by reaction with polyamine. U.S. Pat. No. 4,137,185 teaches reacting C.sub.1 to C.sub.30 mono carboxylic acid anhydrides, and dicarboxylic anhydrides, such as acetic anhydride, succinic anhydride, etc. with an ethylene copolymer reacted with maleic anhydride and a polyalkylene polyamine to inhibit cross linking and viscosity increase due to further reaction of any primary amine groups which were initially unreacted. U.S. Pat. No. 4,144,181 is similar to 4,137,185 in that it teaches using a sulfonic acid to inactivate the remaining primary amine groups when a maleic anhydride grafted ethylene-propylene copolymer is reacted with a polyamine. U.S. Pat. No. 4,169,063 reacts an ethylene copolymer in the absence of oxygen and chlorine at temperatures of 150.degree. to 250.degree. C. with maleic anhydride followed by reaction with polyamine. A number of prior disclosures teach avoiding the use of polyamine having two primary amine groups to thereby reduce cross-linking problems which become more of a problem as the number of amine moieties added to the polymer molecule is increased in order to increase dispersancy. German Published Application No. P3025274.5 teaches an ethylene copolymer reacted with maleic anhydride in oil using a long chain alkyl hetero or oxygen containing amine. U.S. Pat. No. 4,132,661 grafts ethylene copolymer, using peroxide and/or air blowing, with maleic anhyride and then reacts with a primary-tertiary diamine. U.S. Pat. No. 4,160,739 teaches an ethylene copolymer which is grafted, using a free radical technique, with alternating maleic anhydride and a second polymerizable monomer such as methacrylic acid, which materials are reacted with an amine having a single primary, or a single secondary, amine group. U.S. Pat. No. 4,171,273 reacts an ethylene copolymer with maleic anhydride in the presence of a free radical initiator and then with mixtures of C.sub.4 to C.sub.12 n-alcohol and amine such as N-aminopropylmorpholine or dimethylamino propyl amine to form a V.I.-dispersantpour depressant additive. U.S. Pat. No. 4,219,432 teaches maleic anhydride grafted ethylene copolymer reacted with a mixture of an amine having only one primary group together with a second amine having two or more primary groups. German published application No. 2753569.9 shows an ethylene copolymer reacted with maleic anhydride by a free radical technique and then reacted with an amine having a single primary group. German published application No. 2845288 grafts maleic anhydride on an ethylene-propylene copolymer by thermal grafting at high temperatures and then reacts with amine having one primary group. French published application No. 2423530 teaches the thermal reaction of an ethylene copolymer with maleic anhydride at 150.degree. to 210.degree. C. followed by reaction with an amine having one primary or secondary group. The early patents such as U.S. Pat. Nos. 3,316,177 and 3,326,804 taught the general concept of grafting an ethylene-propylene copolymer with maleic anhydride and then reacting with a polyalkylene polyamine such as polyethylene amines. Subsequently, U.S. Pat. No. 4,089,794 was directed to using an oil solution for free radical peroxide grafting the ethylene copolymer with maleic anhydride and then reacting with the polyamine. This concept had the advantage that by using oil, the entire reaction could be carried out in an oil solution to form an oil concentrate, which is the commercial form in which such additives are sold. This was an advantage over using a volatile solvent for the reactions, which has to be subsequently removed and replaced by oil to form a concentrate. Subsequently, in operating at higher polyamine levels in order to further increase the dispersing effect, increased problems occurred with the unreacted amine groups cross-linking and thereby causing viscosity increase of the oil concentrate during storage and subsequent formation of haze and in some instances gelling. Even though one or more moles of the ethylene polyamine was used per mole of maleic anhydride during imide formation, cross-linking became more of a problem as the nitrogen content of the polymers was increased. One solution was to use the polyamines and then to react the remaining primary amino groups with an acid anhydride, preferably acetic anhydride, of U.S. Pat. No. 4,137,185 or the sulfonic acid of U.S. Pat. No. 4,144,181. The cross-linking problem could also be minimized by avoidance of the ethylene polyamines and instead using amines having one primary group which would react with the maleic anhydride while the other amino groups would be tertiary groups which were substantially unreactive. Patents or published applications showing the use of such primary-tertiary amines noted above are U.S. Pat. No. 4,219,432, wherein a part of the polyamine was replaced with a primary-tertiary amine; U.S. Pat. No. 4,132,661; U.S. Pat. No. 4,160,739; U.S. Pat. No. 4,171,273; German No. P2753569.9; German No. 2,845,288; and French No. 2,423,530. Still another problem arose when using free radical initiators with mineral oil as the grafting medium is that as the grafting levels were increased to increase the dispersancy level, a larger proportion of the oil molecules in turn became grafted with the maleic anhydride. Then upon subsequent reaction with the amine these grafted oil particles tended to become insoluble and to form haze. To avoid using initiators, such as peroxides, for grafting and to avoid the use of oil, several of the above-noted patents utilized thermal grafting in solvent, preferably while using an ethylene copolymer containing a diene monomer so as to achieve an "ene" type reaction between the unsaturation resulting from the diene moiety and the maleic anhydride. However, generally such "ene" reactions are slower than peroxide grafting. The present invention represents a further improvement over the art in that it permits the utilization of the generally less expensive polyalkylene polyamines having two primary amine groups, while achieving good dispersancy levels, inhibiting cross-linking and allowing initiator, e.g. peroxide, grafting in oil. The preceding can be obtained by reacting the polymer grafted with the maleic anhydride with an acid component, such as an alkenyl succinic anhydride, together with the polyalkylene polyamine, e.g. polyethyleneamine, or with the reaction product of the acid component and polyalkylene polyamine. In either case cross-linking between ethylene copolymer molecules is reduced or inhibited since many of the polyamine molecules will have one primary group reacted with a maleic anhydride moiety of the ethylene copolymer, while its other primary group is reacted with the acid component. A further advantage is when the grafting is carried out in an oil solution, using a free radical initiator, e.g. a peroxide which is generally much faster with better control, than say depending upon thermal cracking or degradation, oil molecules which become grafted with maleic anhydride and react with the amine, will, to a substantial extent, be solubilized if a long chain acid component is used. Another advantage is that acid component reacted with polyamine which does not become reacted with the grafted ethylene copolymer can be effective per se as a dispersant additive if it has above about 50 carbons, or if it has less than about 50 carbons it may have other properties such as acting as an antirust agent. Thus, long chain acid with more than 50 carbons, usually alkenylsuccinic anhydride, reacted with amine to form oil dispersant additives is well known in U.S. Pat. Nos. 3,154,560; 3,172,892; 3,219,666; etc., while derivatives of acids with less than 50 carbons are taught in U.S. Pat. Nos. 2,466,530; 2,568,876; 2,604,451; 3,004,987; etc. A further aspect of the present invention is when grafting with a free radical initiator, in solvent or oil, that adding the maleic anhydride and free radical initiator either slowly and continuously over a period of time, or in a series of increments, appears to increase the reaction of the maleic anhydride with the polymer as opposed to undesired side-reactions with oil or solvent molecules. This in turn can permit grafting to higher levels of maleic anhydride without excessive haze.
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Free Shipping on all orders $35 and up. We offer standard delivery in 3 business days or less. Please see our shipping map below for estimated times. Estimated standard delivery time to the U.S. and Puerto Rico Delivery time estimates do not apply to large or heavy items that require special shipping (including most TVs), items shipped directly from the manufacturer, or out-of-stock items. Some items that ship from the manufacturer can only be delivered to addresses within the 48 contiguous states. Delivery time for standard shipping to any of the 50 U.S. states or Puerto Rico is 1-3 business days. Saturday, Sunday and national holidays are not considered business days for delivery purposes. Ask an expert advisor Focal's Polyglass VR component speaker systems use precision craftmanship and advanced materials to make a strong sonic impression. Each system includes two tweeters, two woofers, two crossover networks, grilles, and assorted hardware. 2-layer woofer cone The 130 VR system features a 5-1/4" woofer with a Polyglass cone that's created by depositing a layer of hollow glass microbeads over a layer of cellulose pulp. This unique material combines the warm sound of cellulose with the incredible strength of glass, for a cone that responds rapidly with extremely low resonance. A butyl rubber surround helps control cone movement and promotes high power handling. The zamak (zinc alloy) basket provides a non-magnetic, non-resonant housing that won't color the sound. Unique tweeter design Focal designed the aluminum/magnesium inverted dome tweeter to disperse high frequencies evenly for a big, open soundstage. The external 2-way crossover ensures a smooth transition from lows to highs, so vocals and instruments sound natural. You can select from 3 tweeter levels to get the right balance in your vehicle. Grilles are included. Why install component speakers? A component speaker system gives you the best possible performance from your car audio system. A system consists of separate woofers, tweeters, and crossovers, each designed to cover one specific range of frequencies. As separate components, the woofer can move freely to deliver more powerful performance, while the tweeter can be custom-mounted in a better spot up closer to your ears, revealing a whole new world of detail. Separate crossovers are far superior to the simple filters wired into full-range speakers, so the components work together for smoother, more focused sound. Product Research Woofer Polyglass Cone: The woofer cone has a cellulose pulp base and is coated with a uniform deposit of hollow glass microballs. The addition of the Polyglass layer significantly increases the cone's rigidity without adding much weight. This combination takes advantage of the accuracy and neutrality of the hard outer surface, but maintains the superior damping characteristics of the cellulose pulp. Surround: The butyl rubber surround is resistant to ultraviolet rays, temperature extremes, and humidity to add to the speaker's reliability and longevity. Phase Plug: The bullet-shaped aluminum phase plug in the center of the woofer ensures a smooth, flat off-axis frequency response by preventing the high frequency sound waves emanating from one side of the cone from interfering with sound waves from the other side of the cone. Zamak Basket: The woofer features a cast Zamak basket. Zamak is a rigid alloy of Zinc, Aluminum, Magnesium, and Copper. Zamak is non-magnetic. Tweeter Inverted Dome Tweeter: The tweeter is an inverted aluminum/magnesium dome, producing a broad sound stage. The tweeter has a Neodymium magnet to provide a powerful magnetic field for the voice coil, while still maintaining the tweeter's compact dimensions. Mounting Options: The tweeter can be surface or flush mounted using the included adapters. Focal recommends flush mounting, but the included angled cup allows surface mounting at one of two angles; approximately 10° and approximately 30°. Crossover Components: Focal uses audiophile grade polypropylene capacitors and air core inductors to ensure high definition and a dynamic sound quality. Tweeter Level: You can adjust the output level of the tweeter on the crossover to -6 dB, -3 dB, or 0 dB. Crossover Slopes: The crossover uses 2nd order, 12 dB per octave low-pass and high-pass filters. The crossover frequency for both is 4,000 Hz. Wiring: The inputs and outputs are screw terminals; they will accept bare wire or spade connectors up to 0.3" wide. Dimensions Tweeters: Flush Mount Angled Surface Mount Mounting Height 0.274" 1.186" Depth 0.688" (1.01" including screw) 0.527" (screw depth) Frame Diameter 2.054" 1.842" Cutout Diameter 1.828" N/A Crossover: Width: 2.537" Height: 1.246" Depth: 4.704" Our Product Research Team At Crutchfield, you'll get detailed, accurate information that's hard to find elsewhere. That's because we have our own in-house Product Research team. They verify what’s in the box, check the owner's manual, and record dimensions, features and specs. We stay on top of new products and technologies to help people make informed choices. * Agree to Terms By checking this box you agree your review becomes the property of Crutchfield, that you are over 18 years of age, that you own or have owned this product, and that you are located within the United States or its territories. Please see our Review Guidelines for more information. We reserve the right (but are not obligated to) review all submissions and edit or remove any review in any manner which we deem necessary. Your review should be posted within seven days. Focal Polyglass 130 VR Written By Matt, DesMoines, IA on Saturday, November 21, 2009 I have 2 sets of 165 VR in my door panels. It's the same product just a bigger woofer. And the tweeters scream. The highs are so clear at high volumes it's amazing. No distortion at all. Of course I have them powered by an amp that is pushing 75 watts rms/channel. I don't think I need to tell you but you will want an amplifier for these. If not you're wasting your money. I rated them a 4 because they don't have much bass. But that's what your subs are for. These were my first focals and now I wont buy anything else, and if you can afford them I wouldn't recommend anything else either.
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HOUSTON (AP) — A National Guard member arrested on a sexual assault charge while serving on the U.S.-Mexico border lost his job as a county jailer last year after being arrested for drunken driving. Records obtained by The Associated Press on Thursday show Luis Carlos Ontiveros was fired in January 2017 by the El Paso County Sheriff’s Office. The sheriff fired Ontiveros one month after he was arrested for driving while intoxicated, accusing him of crashing his car while drunk and lying about it to police and investigators. Ontiveros remained a member of the Texas Army National Guard. He was arrested Monday in Alpine, Texas, and accused of sexually assaulting a woman at a motel. Ontiveros hasn’t responded to phone messages. The Guard declined to comment but said it is cooperating with investigators. Sign up for Daily Newsletters Manage Newsletters Copyright © 2020 The Washington Times, LLC.
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The suit, filed in US District Court: Western District of Arkansas, alleges that Acxiom withheld information about a significant decline in its international operations; that the company failed to properly and timely account for impaired assets related to its international operations; and that, as a result, statements made by the defendants about the company's financial performance and expected earnings were misleading. Law firm Bronstein, Gewirtz & Grossman filed a similar class action suit on April 28, according to a statement from the firm. The statement uses the exact same terminology as Izard Nobel's grievance to classify Acxiom's alleged offenses. “With regard to recent media coverage about a class action suit filed against Acxiom on behalf of an institutional investor, it is the belief of Acxiom that it has acted in accordance with the law and has not done anything improper,” the Little Rock, Ark.-based company said in a statement. “We intend to vigorously defend the merits of the case.” Former Acxiom CEO John Meyer and former EVP and CFO Christopher Wolf, who both resigned on March 30, are named as defendants in suit, in addition to the company itself. The complaint states that Meyer and Wolf are liable for making false statements, failing to disclose adverse facts, deceiving the public and inflating the price of Acxiom stock. The suit maintains that Acxiom stock traded at “inflated prices” while the company withheld knowledge of a decline in operations. Once the “revelations reached the market,” around the time of Meyer's departure, stocks fell 27.6%, according to the suit. The allegations date back to October 27, 2010, when Acxiom announced its second quarter 2011 earnings. On an earnings call, Meyer “made numerous positive statements about the company's business, operations and prospects,” according to the suit. Similar statements were allegedly made during a Q3 2011 earnings call, as well. The plaintiffs are requesting damages and interest, legal fees and other relief as the court may deem proper.
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A bed to sleep in and a couch where you can relax may be simple pleasures in American life. A handful of Greenbriar Apartments residents will again know those pleasures after management delivered new furniture Thursday. It has been more than a month since the residents’ furniture was thrown out to halt a bed bug infestation that has been plaguing the apartment building. The 66-unit apartment building at 121 Waverly Road is low-income housing for seniors and others with disabilities. Feb. 20, management slipped notes under the doors of approximately a dozen tenants, saying employees would be there the next day to throw furniture identified as being infested over the balcony, then taking it away in a Dumpster. Intrepid Professional Group owns the complex and did not return repeated requests for comment except to say, “The arrangements with the tenant's furniture is confidential.” Seven families were able to pick out new couches, mattress sets, chairs, a futon and a few recliners at Holland Furniture, said Judy Plaggemars, who with her husband, Paul, owns the store at the corner of 32nd and Lincoln. About 11 apartments were affected. It isn’t clear what makes up that difference. The new and consignment furniture retailer offered steep discounts and worked within the confines of each voucher — “knowing they didn’t have more money to spend,” Plaggemars said. When asked why, she said, “I want to be the hands of Christ in the world.” Engedi Church stepped in as a contact point for monetary donations to help the residents. It passed on the money to Intrepid Management Group, which used it to partially offset the cost the furniture vouchers. Most of the residents received $1,000 vouchers, said Katie Bach, with the Michigan State Housing Development Authority. One person received $3,000 because specialty or additional furniture had been destroyed. “We feel like the owner and management are making a good faith effort to take care of this situation, and that’s all we can ask,” Bach said. Greenbriar resident Sue Coulter refused to give up her furniture on that Thursday afternoon in February. “I don’t need new,” she said. “I’m content with what I have unless they can show me where there’s something living in it.” The first official complaint about bed bugs at Greenbriar low-income senior housing came in June of 2012. There have been four more since then. Bed bug infestations are not an issue over which the city of Holland has jurisdiction, said Sue Harder with the city’s community and neighborhood services department. The bug-sniffing dogs returned to inspect the apartments again Thursday morning and gave them the all-clear, according to a source close to the situation. Page 2 of 2 - “(Intrepid Professional Management) are really trying to do the best for the residents,” Plaggemars said. “They really have come through. … We’re just happy the residents are getting taken care of.”
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Parinari campestris Parinari campestris is a species of tree in the plant family Chrysobalanaceae which is native to Trinidad, the Guianas, Venezuela and Brazil. It is reputed to have aphrodisiac properties. Description The species is a tree which grows up to tall. Young branches are hairy but they become hairless as the tree ages. The leaves, which are long and wide, are smooth and shiny on their upper surfaces. The lower surface of the leaves is hairy with prominently raised veins. The stipules are broad at the base but narrowing to a point; they are about long. The flowers are hermaphroditic with five white petals, seven stamens and seven or eight staminodes. The fruit is a fleshy drupe, long and wide. Taxonomy The species was described by Jean Baptiste Christophore Fusée Aublet is 1775, together with P. montana. In his 1972 monograph, Ghillean Prance designated P. campestris as the type species of the genus due to the fact that Aublet's illustration of P. montana contains errors and includes parts of plants belonging to two different species of Parinari. In 1789 Antoine Laurent de Jussieu latinised Aublet's name for the genus to Parinarium; although incorrect by current rules of taxonomy, Jussieu's version of the name was widely used over the next two centuries. Distribution Parinari campestris grows in open forests, nears the edges of savannas, and along river banks. It ranges from Trinidad in the north, through parts of Venezuela, Guyana, Suriname and French Guiana into northern Brazil. Uses Parinari campestris is one of several species including Richeria grandis and Roupala montana which known by the common name bois bandé. These species are reputed to have aphrodisiac properties. The species is also used ritually in winti, an Afro-Surinamese religion. Extracts from P. campestris leaves have been shown to inhibit the interaction between Vascular endothelial growth factor A and Vascular endothelial growth factor receptor 1. References campestris
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FIG. 1 (Prior Art) is a perspective view of stacked connector assembly 1. Stacked connector assembly 1 includes a male surface mount connector 2 and a female surface mount connector 3. FIG. 2 (Prior Art) is cross-sectional view of male connector 2 and female connector 3 of FIG. 1. The cross-section of the male connector 2 reveals a pair of L-shaped metal pieces 4 and 5, referred to here as pins. These pins are inserted into holes in an insulative portion 6 so that the pins stay in place as illustrated. The upper portion of pin 4 is a solder tail 7. The upper portion of pin 5 is a solder tail 8. The solder tails 7 and 8 are soldered to corresponding conductors of a printed circuit board 9 so that male connector 2 is physically fixed to the first printed circuit board. The cross-section of the female connector 3 reveals a pair of metal inserts 10 and 11. Metal insert 10 has a solder tail portion 12 and a flexing contact portion 13. Metal insert 11 has a solder tail portion 14 and a flexing contact portion 15. The inserts 10 and 11 are inserted into holes in an insulative portion 16 so that the inserts stay in place as illustrated. The solder tail portions 12 and 14 are for soldering to corresponding conductors on the top of a second printed circuit board 17. FIG. 3 (Prior Art) is a cross-sectional view of male connector 2 and female connector 3 of FIG. 2 when the two connectors are mated. Contact portion 13 presses inward to the right on pin 4 thereby establishing a first conductive path through the connector assembly between solder tail 7 and solder tail 12. Similarly, contact portion 15 pressed inward on pin 5 to the left thereby establishing a second conductive path through the connector assembly between solder tail 8 and solder tail 14. FIG. 4 (Prior Art) is a simplified diagram representing the orientation of the conductive portions within the connector assembly. The diagram is of a cross-section taken through the two connectors 2 and 3 about halfway between, and parallel to, printed circuit boards 9 and 17. The dark rectangles are very simplified representations of cross sections of conductive portions. FIG. 5 (Prior Art) is a perspective view of an improved connector assembly 18 that includes a male connector 19 and a female connector 20. Note that every second one of the solder tails in the two rows of solder tails on the upper surface of male connector 19 are electrically coupled together. Reference numeral 21 illustrates one such pair of solder tails that is formed as a bar or strip. FIG. 6 (Prior Art) is a cross-sectional diagram of the connector assembly 18 of FIG. 5. The cross-section of FIG. 6 is taken through the connector assembly at the location of pair 21. Rather than there being two separate pins in the male connector 19 as in the case of FIG. 2, there is a single piece 22 of stamped metal that is inserted into insulative portion 23. Metal piece 22 has two solder tails 24 and 25 that are usable to solder the male connector 19 to a first printed circuit board 26. Rather than there being two separate metal inserts in the female connector 20 as in the case of FIG. 2, there is a single piece 27 of stamped metal that has two contact portions. Piece 27 has two solder tails 28 and 29 that are usable to solder female connector 20 to a second printed circuit board 30. FIG. 7 (Prior Art) is a view taken at the same sectional line as FIG. 6, except that FIG. 7 shows the connector assembly structure when the two connectors 19 and 20 are mated. Note that the flexing contact portions 31 and 32 press inward and make electrical contact with metal piece 22. Note that a large portion of the cross-sectional area of the connector assembly in FIG. 7 is metal that is electrically coupled together. FIG. 8 (Prior Art) is a cross-sectional view through the connector assembly 18, but the cross-section is taken through a pair of solder tails that are not joined together. The cross-section of FIG. 8 appears much like the cross-section of FIG. 2, except that the press fit extension portions on metal inserts 10 and 11 have been eliminated. FIG. 9 (Prior Art) is a cross-sectional view taken in same plane as the cross-sectional view of FIG. 8, except that male connector 19 and female connector 20 are shown in the mated position. Contact portion 33 presses inward to the right on pin 34 thereby establishing a first conductive path through the connector assembly between solder tail 35 and solder tail 36. Similarly, contact portion 37 pressed inward to the left on pin 38 thereby establishing a second conductive path through the connector assembly between solder tail 39 and solder tail 40. FIG. 10 (Prior Art) is a simplified diagram representing the orientation of the conductive portions within the connector assembly of FIG. 5. The diagram is of a cross-section taken through the two connectors 19 and 20 about halfway between, and parallel to, printed circuit boards 26 and 30. The dark rectangles represent cross sections of conductors. The longer rectangle 41 represents the conductive portions illustrated in FIGS. 6 and 7. These conductive portions are coupled to ground potential and form what approximates a ground plane that extends in the vertical dimension in FIG. 10. The smaller rectangles 42 and 43 represent the conductive portions in the plane of FIGS. 8 and 9. Rectangle 43 represents contact portion 37 and pin 38, whereas rectangle 43 represents contact portion 33 and pin 34. The conductors represented by rectangles 42 and 43 are used to conduct differential signals. Note that the topology of the ground portions and signal portions of FIG. 10 comes closer to a microstrip topology in that pairs of signal conductors are disposed side by side with respect to one another, and in that the pair of signal conductors are disposed over a ground plane. Because the topology of FIG. 10 is closer to that of a microstrip topology than is the topology of FIG. 4, the connector assembly of FIG. 5 can handle higher frequency signals that the connector assembly of FIG. 1. One example of a connector assembly that has a form similar to the form of the connector assembly of FIG. 5 is the so-called “Micro GigaCN stacking connector” from Fujitsu, model number FCN-260. The FCN-260 connector assembly is reported to be able to handle signals up to approximately three gigabits per second. A connector assembly is desired that can handle higher frequency signals.
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Dual actions of adenosine on rat peritoneal mast cells. The effects of adenosine and its analogues on cAMP-responses and histamine release of rat peritoneal mast cells were investigated. The adenosine analogue 5'-N-ethylcarboxamidoadenosine (NECA') activates the adenylate cyclase of the mast cell membranes and elevates the cAMP-levels of the intact mast cells. Both effects are antagonized by methylxanthines, suggesting that they are mediated via an A2 adenosine receptor. Adenosine and its analogues enhance the release of histamine from these cells, when the release is stimulated either by the calcium ionophore A 23187 or by concanavalin A. However, this effect is not antagonized by theophylline or 8-phenyltheophylline. In contrast, it is antagonized by the adenosine uptake blockers S-(p-nitrobenzyl)-6-thioinosine (NBTI) and S-(p-nitrobenzyl)-6-thioguanosine (NBTG). It is concluded that adenosine has two different effects on mast cells: it activates adenylate cyclase via an A2 adenosine receptor, and it enhances histamine release via an action at an intracellular site.
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by Karen Ingala Smith In 2016, at least 117 UK women killed by men, or where a man is the principal suspect. 117 women in 365 days is one woman dead every 3.1 days. Awaiting information regarding the deaths of Gurpreet Kaur, Tanussum Winning, and an as-yet-unnamed woman from West Bridgford, Nottingham, Sandra Gill, Michelle Wright, Jean Constant, Debbie Wilkinson, Linda Harding, Kelly Machin, Tracy McPartland and Stacey Tierney. Any updates on these women or others missing from the list gratefully received. Follow Counting Dead Women on Facebook and Twitter.
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Q: imported data to gephi is always a string I'm importing a .gml file into Gephi, that I build using the python module networkx. All of my node attributes and labels are imported as strings instead of floats, which is messing up several things (using node attributes for visuals, and accessing the list of nodes in the scripting console). Is there any way to import data the correct way? Will it change anything to import to Gephi as a different graph format? I'm doing this with an eye to programmatically drawing graphs in Gephi. Thanks! A: You should try including the ID as an attribute. Thats simpler way of solving this (I think). Regards, George G. Vega (author of the R package "rgexf") http://ggvega.com
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2013 Kenyan Super Cup 2013 Kenyan Super Cup may refer to: 2013 Kenyan Super Cup (pre-season), a match played by Tusker F.C. and Gor Mahia F.C. on 23 February 2013 2013 Kenyan Super Cup (post-season), a match played by Gor Mahia F.C. and Tusker F.C. on 14 December 2013
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Q: how to automatically put title in url How does a site like SO put the title of the question dynamically into the url bar. Is this through rewritemapping and mod rewrite and how can I do it on a normal web host. Thanks A: In this URL: https://stackoverflow.com/questions/10903041/how-to-automatically-put-title-in-url the only part that matters is the question ID, 10903041. So just set up a redirection rule that ignores anything at the end of the URL, much like this: RewriteRule /questions/(\d+) question.php?id=$1 The PHP script can then redirect to the correct title if the title is not already provided or is incorrect; much like what happens when you visit https://stackoverflow.com/questions/10903041/why-is-this-question-title-so-wrong?.
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Benton Fraser Benton Fraser (born 1962) is a fictional character in the television series Due South. He is a constable of the Royal Canadian Mounted Police who works in the American city of Chicago, Illinois as Deputy Liaison Officer in the Canadian consulate. He lives in a dangerous neighbourhood at the fictional address of apartment 3J at 221 East Racine, and later at the consulate itself, after his apartment building was burnt down. The character is portrayed by Canadian actor Paul Gross. Fraser's seemingly strange habits, such as tasting evidence and holding the door for anyone and everyone, add hilarity and whimsy to the show. As Fraser often explains; "I first came to Chicago on the trail of the killers of my father, and for reasons that don't need exploring at this juncture I have remained, attached as liaison with the Canadian Consulate." Fraser is a strait-laced Canadian, and his faith in the honour and goodness of others tends to lead to interesting and humorous moments. Described as an "outdoors Sherlock Holmes", his behaviour often leads to the frustration of his de facto partner, Chicago detective Raymond Vecchio, played by David Marciano. His other "best friend," a deaf half-wolf, Diefenbaker, named after the Canadian Prime Minister, John Diefenbaker, reads lips in both English and Inuktitut, and often assists in the capture of criminals. In the third and fourth seasons of the show, Fraser teamed up with Detective Stanley Raymond Kowalski, after Ray Vecchio went undercover in the Las Vegas Mafia. He is usually called "Fraser" by his friends and colleagues - some old friends will call him Benton or Ben at times. Ray calls him Benny or Fraser, (often mispronouncing it "Fray-sure" as in the NBC sitcom Frasier). Character Benton Fraser was conceived in an igloo, (according to his father), and was born out in a field, and grew up in Inuvik, Northwest Territories; and Tuktoyaktuk, Northwest Territories. After his mother was killed when he was still young, Benton was raised by his paternal grandparents, who were traveling librarians. His mother, Caroline, was killed when he was an 8-year-old boy, and his father, Bob Fraser, (played by Canadian actor Gordon Pinsent), was murdered in the pilot episode, at this point, Benton had been with the RCMP for 13 years. Bob, or "Fraser Sr.," as he is sometimes known, was a legendarily effective officer in the RCMP and often appears to his son as a ghost throughout the series to offer help and advice. Other relatives include an Uncle Tiberius, (who died wrapped in Cabbage leaves, which the family assumes to have been a freak accident, first mentioned in "The Gift of the Wheelman" in season 1,) and an Aunt Winnie, (mentioned only in "Perfect Strangers", in season 3). According to best friend, Ray Vecchio, in An Eye for a Eye, Benton's problem is that "if [he] sees a problem, [he's] gotta fix it, [he] can't even go to the mens room without stopping to tell some simple, stupid, charmingly-witty Inuit story, that inspires people to take on the world's social ills." In "The Blue Line", in season 1, it is revealed that Benton is a fan of Ice hockey, and that he used to play it as a child; and in "Asylum", in season 3, it is shown that Benton is also a fan of curling. Fraser has had an unfortunate recurring relationship with Victoria Metcalf, a bank robber with whom he became infatuated after pursuing her into and then helping her survive a lengthy winter storm. After the storm was over, Fraser turned Victoria in to the authorities and she was sent to prison. This encounter is first outlined in episode 14 of series 1, "You must remember this"; during a stake-out Fraser comes the closest to 'baring his soul' before turning to find Vecchio asleep. That episode fades with Fraser looking at a slightly crumpled black-and-white photo of her. She later resurfaced in Chicago, blackmailing Fraser into helping her use the money from the bank robbery to buy jewels on the black market, threatening to have Ray Vecchio framed for corruption. She left Chicago soon after her plot unraveled, and was not seen again. Having little experience with romantic matters, Fraser appears to have suppressed his emotions, often for comic effect in the series, and buried himself in the masculine pursuits of law enforcement and campcraft. His super-human detective abilities provide humorous contrast with his inability to interact with women. His fixation upon the criminal Metcalf, and later, his superior officer, Margaret Thatcher, (no relation to the British prime minister), was unreasonable, and he may have used his attraction to an unavailable woman as a mechanism for avoiding change in his own life. In the ITV documentary South Bound co-star David Marciano said it was vital that the character of Fraser be both innocent but also unemotional. Actor Daniel Kash, (Detective Louis Gardino in the series), in the same documentary observed about Fraser that 'You'll never see that character cry. You'll sense that he'll be crying inside but you'll never see tears going down his face. He's just too buffed for that, and too reserved.' In the episode Bounty Hunter, Fraser meets a woman who seems very compatible with him, but his father warns Benton off. Fraser Sr tries to get his son to understand that the woman is not the one who is vulnerable, but Benton. For all of his son's physical self-reliance, the young constable needs emotional maturing. Fraser eventually discovered he had a half-sister, Maggie MacKenzie, in the season four episode Hunting Season. Because Bob Fraser is her father, she can also see his ghost. Just like her father and half-brother, Maggie is a member of the RCMP. She arrived in Chicago pursuing the killers of her husband, under circumstances similar to Fraser's own arrival in the city, though she soon returned to Canada, unlike Fraser, who remained in Chicago for some time. Fraser wears his uniform stetson hat both in uniform and out. When he loses it, he seems to get into trouble. Fans of the show have thus nicknamed it the Stetson of Invulnerability. Fraser carries his paper money inside his hat. He frequently only has Canadian currency with him as it is "regulation" to be paid in that currency. Fraser's apartment is at 221 East Racine. The neighbourhood is dangerous, but Fraser liked the apartment for its close proximity to his workplace. Series finale Fraser would eventually return to Canada and, along with Stanley Kowalski, set out on an adventure to find the hand of Sir John Franklin, an explorer who disappeared while trying to discover the Northwest Passage. (The soundtrack for that segment was Stan Rogers's song "Northwest Passage".) As the series ended with the beginning of their expedition, it is unknown what has happened to Fraser or Kowalski since then. His closing remarks: "If we find it...we'll let you know." The ITV documentary, made nine years after the series ended, concludes with Paul Gross saying "We never did photograph it, but I can tell you that we, (Benton and Stanley,) found it." References External links Benton Fraser at TV IV Category:Television characters introduced in 1994 Category:Fictional immigrants to the United States Category:Due South characters Category:Fictional police constables Category:Fictional Canadian people Category:Fictional characters from the Northwest Territories Category:Fictional Royal Canadian Mounted Police officers
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A comprehensive species to strain taxonomic framework for xanthomonas. ABSTRACT A comprehensive classification framework was developed that refines the current Xanthomonas classification scheme and provides a detailed assessment of Xanthomonas diversity at the species, subspecies, pathovar, and subpathovar levels. Polymerase chain reaction (PCR) using primers targeting the conserved repetitive sequences BOX, enterobacterial repetitive intergenic consensus (ERIC), and repetitive extragenic palindromic (REP) (rep-PCR) was used to generate genomic fingerprints of 339 Xanthomonas strains comprising 80 pathovars, 20 DNA homology groups, and a Stenotrophomonas maltophilia reference strain. Computer-assisted pattern analysis of the rep-PCR profiles permitted the clustering of strains into distinct groups, which correspond directly to the 20 DNA-DNA homology groups(genospecies) previously identified. Group 9 strains (X. axonopodis) were an exception and did not cluster together into a coherent group but comprised six subgroups. Over 160 strains not previously characterized by DNA-DNA hybridization analysis, or not previously classified, were assigned to specific genospecies based on the classification framework developed. The rep-PCR delineated subspecific groups within X. hortorum, X. arboricola, X. axonopodis, X. oryzae, X. campestris, and X. translucens. Numerous taxonomic issues with regard to the diversity, similarity, redundancy, or misnaming were resolved. This classification framework will enable the rapid identification and classification of new, novel, or unknown Xanthomonas strains that are pathogenic or are otherwise associated with plants.
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Tuesday, 20 March 2012 careerprakashan.com/ The Constitution of India, under Article 102, clearly stipulates that a person shall be disqualified for being chosen as, and for being a member of either House of Parliament if he holds any office of profit under the government of India or the government of any State (other than an office exempted by the Parliament by law), but not a Minister for the Union or for a State. If a question arises as to whether a Member of Parliament has become subject to disqualification by virtue of holding the office of profit, the President of India shall take a decision on the matter on the basis of the opinion of the Election Commission of India, under Article 103 of the Constitution. The decision of the President in this regard shall be final and cannot be questioned in any court of law. Similar and analogous provisions exist for the Members of Legislative Assemblies of the States, under Article 191.
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Q: I am getting issues if I use @property(atomic,retain)NSString *myString Possible Duplicate: Atomic vs nonatomic properties I am getting issues (errors) if I use @property(atomic,retain)NSString *myString like Expected a property attribute before "atomic". I studied the difference between atomic and nonatomic from Stack Overflow question What's the difference between the atomic and nonatomic attributes?. Where do I use atomic and nonatomic? A: Note that you cannot use the attribute atomic. There is either non-atomic or none (atomic is the default case). So you are looking for @property(retain) NSString *myString;.
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Michael Kruger Dr. Michael J. Kruger is president and Samuel C. Patterson Professor of New Testament at Reformed Theological Seminary in Charlotte, N.C. He is author of Canon Revisited: Establishing the Origins and Authority of the New Testament Books. Inerrancy is not a popular term in the world of biblical studies today. For many, it is viewed asananti-intellectual, fear-motivated invention of nineteenth-and twentieth-century American fundamentalists who were tryingto protect the Bible’s authority from the rising tide of Enlightenment …Read More We live in a world filled with competing truth claims. Every day, we are bombarded with declarations that something is true and that something else is false. We are told what to believe and what not to believe. We are …Read More
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A civil lawsuit was filed last week against an off-duty police officer who dragged a teenage boy and fired his weapon in front of minors in Anaheim, California, on Feb. 21. The teen’s parents, Alma Jimenez and John Dorscht, filed the suit in Orange County Superior Court against Los Angeles Police Officer Kevin Ferguson, The Orange County Register reported. They claim that the cop brutally attacked their 13-year-old son on his way home from school and violated his civil rights. The lawsuit alleges that Ferguson was standing outside his own home drinking a beer when a girl walked across his lawn. Ferguson “became irate” and yelled profanities at the girl, which prompted the teen to tell the man to speak to her “in a nicer manner,” according to the suit. Facebook The teen’s parents claim that Ferguson assaulted and falsely imprisoned the teen and caused the teen emotional distress, the Los Angeles Times reported. Witnesses used camera phones to film Ferguson as he dragged the teen down a sidewalk and onto a lawn. As seen in the video above, a group of minors followed along, asking Ferguson to let the boy go. One kid rushed Ferguson in an attempt to free the boy, causing them both to fall in a bush. Another teen tried to punch Ferguson but missed. Ferguson then pulled a gun from his waistband and fired toward the ground, sending the group of teens running away. Anaheim police arrested the 13-year-old boy for criminal threats and battery and a 15-year-old boy for assault and battery. No one was struck by the gunfire during the altercation. Anaheim police did not file any charges against Ferguson, citing insufficient evidence, according to CBS LA. Anaheim police said in a press release issued the day after the incident that the teen had threatened to shoot Ferguson, which prompted the off-duty officer to attempt to detain the teen. Dorscht, the teen’s father, told the OC Weekly that his son told the officer “I’m going to sue you,” but the officer heard “shoot” instead of “sue.” Videos of the violent encounter went viral, sparking protests and calls for the officer’s arrest.
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Colditz (TV series) {{Infobox television |show_name = Colditz |image = Colditz.jpg |caption = Colditzs title card |runtime = 1 Hour |creator = Brian DegasGerard Glaister |starring = Jack HedleyRobert WagnerDavid McCallumBernard HeptonEdward HardwickeAnthony Valentine |country = United Kingdom |network = BBC1 |first_aired = |last_aired = |num_series = 2 |num_episodes = 28 }}Colditz'' is a British television series co-produced by the BBC and Universal Studios and screened between 1972 and 1974. The series deals with Allied prisoners of war imprisoned at the supposedly escape-proof Colditz Castle when designated Oflag IV-C during World War II, and their many attempts to escape captivity, as well as the relationships formed between the various nationalities and their German captors. Colditz was created by Brian Degas working with the producer Gerard Glaister, who went on to devise another successful BBC series dealing with the Second World War, Secret Army. Technical consultant for the series was Major Pat Reid, the real British Escape Officer at Colditz. One of the locations used in filming was Stirling Castle. Characters BritishLieutenant Colonel John Preston (Jack Hedley) - Senior British Officer, Colonel Preston is the embodiment of British stiff upper lip. He is mostly emotionless, intelligent, respected by his troops, and normally rigid in his application of principles. He gets along quite well with the accommodating Kommandant, whom he respects and is adept with in negotiating. His only real sources of passion are recollections of his time in the trenches in World War I and his wife Caroline, whom he married late and had to leave behind to go to war.Captain Pat Grant (Edward Hardwicke) - Captain Grant is the first British escape officer in Colditz. He is mild-mannered and mostly level-headed. He often serves as an arbiter between his fellow officers' passion and enthusiasm and Colonel Preston's clinical calmness. The fictional Grant resembles Pat Reid, former POW who was the technical advisor for the series.Flight Lieutenant Simon Carter (David McCallum) - Flight Lieutenant Carter is a pugnacious young RAF officer who enjoys baiting the German guards and is very impatient to escape. He misses his young wife, Cathy, very much, and seeks to return to her. He finds himself frequently in solitary confinement. In the second season, he mellows a bit as he accepts the post of escape officer and is tempered by that responsibility. The fictional Carter resembles the real Colditz inmate Flight Lieutenant Dominic Bruce OBE MC AFM KSG MA RAF, the legendary 'Medium Sized Man' from IX Squadron, who was sent to Colditz after escaping from Castle Spangenberg. Bruce was the author of one of the most celebrated of all escapes from Colditz, the so-called 'Tea Chest' escape, a replica of which was featured in the Imperial War Museum's 'Great Escapes' exhibition.Captain Tim Downing (Richard Heffer) - Captain Downing is generally the devil's advocate of the group. While he seems to be the most pessimistic of the British contingent, his criticisms are often insightful and valid. His character most closely resembles that of the Public School "Officer Class" stereotype. He is ambitious, views himself as the second-in-command, and seeks the post of escape officer. He is often at odds with Colonel Preston, whom he challenges quite frequently. He rarely participates in escape attempts himself but provides reliable support for escapees. Downing is portrayed with a handlebar moustache.Captain George Brent (Paul Chapman) - Captain Brent is the most nervous and least confident of the officers but is capable of having brilliant ideas. He is unfortunately known for the number of times he has bungled escapes or ruined others' chances at escape. He has insomnia, and often worries about the future, generally having a pessimistic outlook on his captivity. However, he has occasionally been extraordinarily brave, such as in the episode "Ghosts" where he remained holed up in dreadful conditions, voluntarily, for several weeks. An accomplished artist, Brent uses his skilfulness to sketch a likeness of a refuse collector in the episode "Court Martial" in order to aid and abet an escape attempt by Flight Lieutenant Carrington. He has a weakness for gambling, and at one time lost his house, home to his infirm father, having involved himself in a card school with a notorious card sharp, Flight Lieutenant Collins. Brent is usually portrayed wearing a cricket sweater like the real life Rupert BarryLieutenant Dick Player RN (Christopher Neame) - Lieutenant Player is a quiet but determined officer from the Royal Navy. His perfect German and history of living in Germany cause the Germans to suspect he is a spy at first, which causes him a great deal of trouble. Once in Colditz, though, he is a keen and cool escaper, and participates in some of the most daring and fantastic escape attempts of the series.Pilot Officer Peter Muir (Peter Penry-Jones) - P.O. Muir is a rash officer who has a reputation for not looking before he leaps. Nevertheless, he is a keen member of the escape team. He formed part of Pat Grant's escape team, but was wounded by a gunshot when he and Player were recaptured.Lieutenant Jordan (Padre) (Donald McDonald) - The Padre is a mild-mannered officer who, in his own words, does "not exactly summon a multitude" with his tedious sermons. His cloth unfortunately often conflicts with his duty to the war effort, and so Colonel Preston generally keeps him out of any escape plans. At one point he protests this with a quotation from 1 Corinthians, "When I became a man I put away childish things". Patrick Troughton played "Padre" in one episode of the first season.Doc (Geoffrey Palmer) - The Doc is featured in three episodes, most prominently in "Tweedledum". He is frustrated by the lack of medicines and views the German village doctor as a quack.Wing Commander George Marsh (Michael Bryant) - A medical orderly and assistant to the British Medical Officer, Marsh is the officer who famously feigned insanity to achieve repatriation.Lieutenant Page (Ian McCulloch) - Lieutenant Page is an antisocial and violent late addition to the British contingent, who appears to have little knowledge of the air force, despite claiming to be an air force officer. Page is not his real name but the identity of the Lysander pilot who was killed while inserting him into France. This character is a British Secret agent on his thirteenth mission and is known to, and being hunted by, the Gestapo. Suffering from Post Traumatic stress syndrome he sees his identity change as a chance to escape the war and hide out in Colditz, the last place the Gestapo would look for him. In reality a Special Operations Executive operative was sent to Colditz in the latter part of Oflag IV-C, Special Air Service founder David Stirling.Flying Officer Jimmy Walker (Peter Winter) - An RAF officer who suspects Lieutenant Page is a German spy, picks a fight with him and as a result ends up with injury to his eyes.Captain George Holland (David Allister) - A member of the escape committee who becomes unstable as he gives up hope from escaping the castle.Lance Corporal Baker (Alec Wallis) - Colonel Preston's personal NCO who has immense respect for his superior.Lieutenant Michael Brown (Sean Roantree) -Captain Walters (Nicholas McArdle) -Corporal Hopkins (Len Lowe) -Squadron Ldr. Tony Shaw (Jeremy Kemp) - An aerial reconnaissance pilot and one of the most highly decorated men in the Allied Forces. In addition to which, according to Hauptmann Ulmann, Shaw is also the most decorated person in Colditz, apart from Major Mohn. An academic lecturer before the war, he becomes obsessed with his idea of an escape using a POW built glider. The real Colditz Cock glider was devised and built by RAF pilot, Bill Goldfinch with Jack Best his partner in the construction.Major Trumpington (Willie Rushton) - A Scottish Commando, captured with two companions during a raid on Boulogne. The German SD intend to implement Hitler's order that all Commandos are to be shot. Despite the best efforts of the SBO, the British escape committee and the Camp Kommandant, Major Trumpington and his two fellow commandos are taken away by the SD for execution but are shot while trying to escape. This episode mirrors the fate of the 'Musketoon' raid commandos who were briefly imprisoned in the solitary confinement cells at Colditz before being shot at Sachsenhausen. Flt Lt Bruce's conversation with the commando leader Capt Black is retold in "Operation Musketoon" by Stephen Schofield.Flight Lieutenant Jack Collins (Ray Barrett) - A late and disruptive arrival who introduces a card school into the British quarters. Captain George Brent joins the school and eventually loses very heavily. Owing £1000, Brent loses his house in a game of 'double or quit'. Collins attempts escape by playing cards with Unterfeldwebel Ernst Krueger, a German quartermaster, cheating to make Krueger lose heavily before bribing him for a workers identity disc. The escape attempt is foiled and Collins is moved out of Colditz but not before the Kommandant retrieves and returns all Brent's losses to the SBO.Lieutenant McDonald (Prentis Hancock). McDonald is portrayed as having a working-class background unlike the private schooled other officers. He is a Scottish commando who receives a letter from his wife informing him she is pregnant by another man. He resolves to escape soon and after initial debating and resistance, is given a place on a French escape plan. He escapes the castle wall and encourages the French escapee to press on without him. Seemingly with a deathwish, McDonald is shot in the wire. The Kommandant reads unposted letters of McDonald's indicating McDonald indeed wanted to die in the escape. McDonald's character has some resemblances to the real life Michael Sinclair. McDonald has red hair as did Sinclair who was nicknamed 'The Red Fox'. Sinclair was the only person killed while escaping from Colditz. However, the nature of Sinclair's fatal escape attempt was very different to that portrayed by McDonald.Lieutenant James Porteous (Jim Norton) - The Colditz Librarian. Although having made two previous escape attempts whilst in transit, having been confined to Colditz Porteous becomes a somewhat staid and unenthusiastic escaper who appears to be happy to sit out the war. A School Master before the war, Porteous strikes up a friendship with the equally (initially) reticent Sqn Ldr Tony Shaw.Cathy Carter (Joanna David) - While not an internee, Carter's wife plays a decent-sized role in the series. Reluctant to let her new husband leave in the second episode, she is devastated to learn he has been shot down and worries that he has not survived. When she learns he is at a POW camp, she keeps in touch with him through letters. Good at crosswords and quick on the uptake, Cathy becomes embroiled in a scheme to connect escaping prisoners with the European underground. In this, she resembles Mary Lagan Bruce (the real-life wife of the 'Medium Sized Man' Dominic Bruce), who once sent her husband a silk escaping map (of Northern Germany) supplied to her by MI9 and concealed in the brass button of a uniform she sent him. This map was featured in the Imperial War Museum 'Great Escapes' exhibition and was subsequently donated to the museum of IX Squadron, RAF Marham, by their son, Brendan Bruce. AmericanFlight Lieutenant Phil Carrington (Robert Wagner) – Flight Lieutenant Carrington is an American officer who volunteered to serve with the British early in the war. As per the real life Micky Burn, he served as a journalist in Berlin before the war and has an intimate knowledge of Germany and German politics, admits to having had some admiration for National Socialism. Carrington appears to be sensible at first, but he is a maverick, which gets him in trouble with the Germans and the British alike. Carrington becomes involved in an escape attempt with Pat Grant, the character based on real life escapee Pat Reid. In reality the officer who escaped with Reid via Hans Larive's Singen route was Canadian Howard Wardle. In later episodes, Carrington is shown to have switched his commission to the US Army Air Corps, and, in that role, is recaptured and sent to Colditz along with the three characters listed below.Lieutenant Jim Phipps (Garrick Hagon) – US POW who becomes the central element of an episode when the Germans categorise him as 'Prominente' on the basis of being the son of a US Ambassador. In reality Lieutenant John Winant Jr., was the son of John Gilbert Winant, US ambassador to Britain.Lieutenant Colonel Max Dodd (Dan O'Herlihy) – Old-school and brash, Colonel Dodd arrives with Major Carrington on his second trip to Colditz, and rapidly becomes the Senior American Officer of that growing contingent. He does not take well to being a prisoner, and often clashes with the Kommandant. Unlike his counterpart Colonel Preston, he is more than willing to take substantial risks with his men in order to accomplish his objectives. In reality the Colonel among the three paratroopers captured in Hungary and sent to Colditz was Colonel Florimund Duke — the oldest American paratrooper of the war.Captain Harry Nugent (Al Mancini) – arrives with Dodd and the return of Carrington. In reality the two real life paratroops arriving with Florimund Duke in August 1944 were Captain Guy Nunn, and Alfred Suarez.Lieutenant Colonel Harrity (Ed Bishop) - Commander of the American troops who liberate the castle in the final episode. He offers Preston the chance to get some "justice", but Preston will have none of it and insists on proper treatment for the Germans. FrenchCapitaine André Vaillant (Gerard Paquis) – Capitaine Vaillant is a stereotypical riviera Frenchman who is self-serving, self-righteous, dashing, and a shameless womaniser.Capitaine Henri Lefevre (Henri Szeps) -Capitaine Duprez (Guido Adorni) -Lieutenant Maurice Tailière (Boyd Mackenzie) -Lieutenant Beausire (Stuart Fell) German Oflag IV-CKommandant (Bernard Hepton) - The Kommandant, known only by his forename "Karl", is a moderate and honourable Oberst (Colonel) of the Wehrmacht. He holds to the old Army ways of respecting enemy officers and adheres to the Geneva Convention to the best of his ability. He has difficulty believing that any authority but the OKW is legitimate, and often finds himself in dilemmas over orders he gets from the Waffen-SS or Reich Security. Fortunately, he has an ally in General Schaetzel, a respected figure in the OKW. With the help of Schaetzel, and Colonel Preston's cooperation, he constantly works to prevent the SS from taking control of the camp. He finds it boring in the camp and can't stand incompetence. When important visitors come round he is usually embarrassed by one prisoner or another. He is aware the British Officers get very restless and hot-headed, but he relies on Colonel Preston to keep them in check. When they do try something he tries to have a shout at Preston, only to find that Preston is made of stern stuff, hardly flinching when he is shouted at and always keeping a straight face; this annoys the Kommandant even more, but he knows there is nothing he can do. He has a young son, Erich, in the Luftwaffe and a wife named Lisa. He worries about Erich, he himself has seen war and fears for his son's safety and that he won't become blood thirsty. He just wishes that everything will run smoothly so that he can get on with his life, and that his son will return home.Hauptmann Franz Ulmann (Hans Meyer) - Hauptmann Ulmann is the Security Officer at Colditz. A calculating and rather robotic individual most of the time, he takes his job of preventing escapes seriously and is sometimes ill at ease with the Kommandant's lax attitude. He took over early from Oberleutnant Lehr, a young and easygoing officer who was drafted to the front lines and was appalled at the lack of discipline among the security forces. Because of his careful planning and sharp eyes and mind, he is able to avert many escape attempts as well as many attempts of the SS to take over the camp. He seems to have been sent by the OKW specifically to help the Kommandant in these matters. While occasionally he comes up with a brilliant scheme, most of his captures are a result of thoroughness. He develops a warm relationship with Carrington over the course of the series. He believes there is no such thing as an escape-proof prison, but he plans to make security such that the prisoners will struggle anyway. Like the Kommandant, he is a Wehrmacht man who has no love of the SS. Ulmann is largely based on real life Reinhold Eggers who later wrote a book presenting the German side of the story. Eggers' book contains a foreword by a former Dutch POW, Damiaen Joan van Doorninck, who commented, "This man was our opponent, but nevertheless he earned our respect by his correct attitude, self-control and total lack of rancour despite all the harassment we gave him."Major Horst Mohn (Anthony Valentine) - Mohn is an entirely fictional character, who joins at the start of the second series. A paratrooper hero with the Knight's Cross of the Iron Cross with Oak Leaves (though the medal shown in the series is the Knight's Cross of the Iron Cross with Oak Leaves and Swords), Major Mohn was severely wounded at Stalingrad by a Russian bayonet and served on Hitler's personal staff before coming to Colditz. He is a Nazi Party member in good standing, and very highly connected (although the series does not mention to whom). He constantly finds himself in conflict with the Kommandant, for he holds the philosophy that the war is still going on at Colditz and is frustrated by what he perceives as the treating of prisoners with "kid gloves". The prisoners loathe him and do whatever they can to foil him or antagonise him at every turn. Unfortunately for them, he is ruthlessly intelligent and occasionally pulls off a devastating capture. Major Mohn is a paratroop officer and his relationship with the SS appears to be fairly chilly. He is visibly upset with the SD orders given at the end of the episode "The Guests" and seems nervous around the Obergruppenführer and Hauptsturmführer in "Very Important Person." It appears that the reason why Major Mohn would prefer to take SS orders unquestioningly than risk SS reprisals is that he appreciates, apparently better than the Kommandant, what the SS is capable of. In contrast to the honourable Kommandant and Ulmann, Mohn is a sinister and villainous character. However his belief in the cause is shaken when he learns that his brother died ignominiously, crushed by a Russian tank.Lieutenant Anton Lehr (Grahame Mallard) - Lieutenant Lehr is the first Security Officer of Colditz, but in the fourth episode is posted to the front. He is easygoing and cheerful most of the time, although he gets the job done with apparent competence. He is not upset at the posting and looks forward to fighting for his country. In reality Paul Priem was the first Security Officer. Pat Reid described Priem as, "the only German with a sense of humour".Major Willi Schaeffer (Michael Gough) - Major Schaeffer is second in command and a friend of the Kommandant. He does not approve of the war. He clashes with Ullmann over his alcohol consumption, and Ullmann warns the Kommandant that his behaviour could cause the SS to take over the camp.Dr. Starb (Kenneth Griffith) - A very stuffy Major who serves briefly on the camp medical staff. He is irritated at the relaxed discipline of the British and decides to enforce saluting. He is a small, short-tempered man who likes to feel superior. He finds many things irritating and the smallest thing can make him angry. He feels that the prisoners and staff at Colditz are lazy and thick. When he gets Carter court-martialled for failing to salute, the Kommandant has him removed for fear of prisoner reprisals. Dr. Starb was apparently based on a real doctor who served in Colditz and had a prisoner court-martialed for failing to salute. Unterfeldwebel Ernst Krueger (Leonard Fenton) - The canteen sergeant, has a strong propensity for playing card games in particular three card brag. Involves himself in playing cards with notorious card sharp Flt Lt Jack Collins which consequently results in him compromising his position. Is caught aiding and abetting a planned escape by Collins as a repayment for his losses in the card school and is subsequently transferred to the military prison at Leipzig to await court martial. A popular character with the other members of the garrison, Krueger is found guilty and subsequently shot by a firing squad which results in antagonism between the German guards and certain British prisoners, particularly Collins. Unterfeldwebel Blatau (Roy Pattison) - An administrative clerk for Hauptmann Ulmann, Blatau prepares the briefing papers which Ulmann uses to thwart an SS takeover of Colditz. Korporal Henneberg (Gertan Klauber) - A camp guard who professes religious piety by handing out Bibles to prisoners, however his outward persona disguises his true identity as that of a thief and bully. Henneberg begins to steal items from the prisoner’s Red Cross parcels, and his behavior results in him being murdered by Captain Alan Marshall. Aware of the actions of Henneberg, the Kommandant decides to disguise his murder as suicide in order to convince the Gestapo that there was no breach of order or discipline inside Colditz. The Kommandant explains the suicide of Henneberg as a consequence of him becoming melancholy upon receiving news that his (Henneberg’s) son, a serving soldier in the Wehrmacht, had been killed in action on the Eastern Front. Oflag VII-CKommandant (Michael Sheard) - Kommandant of Oflag VII-C. Oberst (Colonel) Reichtleig an archetypal German officer, who does all he can to intimidate the newly arrived British prisoners; pointing out the futility of any attempts to escape. GestapoBrauner (Peter Barkworth) - A chief plain-clothes Gestapo officer of unknown rank, Brauner is the stereotype of the sinister police organisation. He is intentionally intimidating with his precision and cold curiosity. He is not afraid to torture uncooperative subjects of his interrogations, as Phil Carrington discovers the hard way.Sturmbannführer (Nigel Stock) and Hauptsturmführer (Terrence Hardiman) - The "Good Cop, Bad Cop" Gestapo team who attempt to determine Player's identity when one of their agents captures him. They seem complete opposites, an angry, loud-mouthed pompous grumpy old man and a calm, helpful, kind vegetarian. But in private, it is revealed, they are just as bad as each other: sly, sneaky and cruel. SSObergruppenführer Berger (David King) - Obergruppenführer Gottlob Berger was the real-life SS commander who took over the Leipzig/Colditz area late in the war and was in charge of the removal of the Prominente from Colditz. He is portrayed in the series as a boisterous but unyielding individual for whom everyone holds a measure of fear, even Major Mohn.Hauptsturmführer Schankel (John Pennington) - Schankel is a yes-man who puts up with the patronising attitude of his superior officer with a smile. MiscellaneousBaumann (Ralph Michael) - The civilian lawyer, sympathetic to prisoners and intent on imposing the letter of German law, who agrees to take Carter's case against Dr. Starb.Erich (Martin Howells) - Erich, the son of the Kommandant, is a Luftwaffe officer in his early twenties. He is anxious to fly for the Luftwaffe, despite the deep concern of his father and mother. Much of the angst of the series centres on the Kommandant's worry that he will not return home.Graf Paul von Eissinger (John Quentin) - Graf Eissinger is a contact of Player's father, who was a diplomat in Germany before the war. He is apparently wealthy and well-connected. He broke his back years ago when his horse fell on him. He had it shot dead. He regretted this later, because due to his broken back (which would not mend) he did not have to go to war. Although he is willing to help identify Player, he has the ulterior motive of using Player in a conspiracy to overthrow Hitler. Player turns this down and is sent to the PoW camp.Gerda''' (Sarah Craze) - Gerda is the young German organist at the Colditz town church. She falls for the dashing Capitaine Vaillant and helps him to escape, feeling for him as she does for her brother who is a POW in Russia. Episodes Series 1 Series 2 Historical accuracy Many of the events depicted in the series have a basis in truth. Exception for dramatic points include the Kommandant's son, Colonel Preston's wife and mother and the completely fictional Major Mohn who appears in series two. While there is not a direct one-to-one relationship between the real and televised characters, most of the televised characters are loosely based on one or several actual persons. The most obvious are Pat Grant (Pat Reid) and Hauptmann Ulmann (Reinhold Eggers). Curiously, no actor was characterised to play, nor any mention was made of Squadron Leader/Group Captain Douglas Bader. He was the RAF pilot who lost both legs in a plane crash before the war and ended up in Colditz after various escape attempts from other camps. He remained imprisoned until the liberation. DVD release A 10-disc Region 2 Box Set DVD of the complete series was released on 15 November 2010 including bonus mock up cards of camp propaganda materials and a stapled character booklet. References External links ColditzCastle.net — Unique Wartime Photos and detailed history of Oflag IVC. VirtualColditz.com — Videos and photos of Colditz Castle as it is today. British Film Institute Screen Online Colditz at the Television Heaven website Category:BBC television dramas Category:Colditz Castle Category:World War II television drama series Category:Television series by Universal Television Category:1972 British television series debuts Category:1974 British television series endings Category:English-language television programs Category:1970s British drama television series Category:British prison television series Category:Television series set in 1940 Category:Television series set in 1941 Category:Television series set in 1942 Category:Television series set in 1943 Category:Television series set in 1944 Category:Television series set in 1945
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May 24, 2010 Outside of water traveling through cracks or other openings the simple reason foundations leak is that concrete is very porous and all the foundation elements are underground. Dampness and flooding is caused by the following: the failure of an existing external waterproofing and bridging/wicking due to the raising exterior water levels below and beside the foundation. The Builders Waterproofing Process The building process dictates a few things. One, that a footer must be poured level and dried before the wall can be either poured (in poured concrete) or set (as in masonry block). Once the footer is poured (see the image below) and dried then it is ready to support the foundation walls. There is only one problem. Once the footer is poured and dried any other concrete that is added on top of it will not adhere to it completely. This lack of adherence between two differently cured mixes is called a “cold joint”. As the new wall dries it forms a seam running the entire perimeter where the floor/wall/footer meet. When this seam is placed more than a few (4-18 inches) under ground it will leak water quite easily given enough water movement around the foundation. It is apparent when looking at the image above of a poured footer how low the basement floor will actually be. It will actually rest on top of that footer. In a heavy rain there will easily be a couple of feet of water in that hole. This water sits directly on top of the footer and wall seam. The below image is just prior to the back filling of the dirt next to a new concrete wall. Even after back fill there is still a tremendous amount of water against the wall after a rain. Adding the dirt does not remove the water that will stand there it only increases the overall pressure on the wall.
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Worcester Lunch Car Company Worcester Lunch Car Company was a manufacturer of diners based in Worcester, Massachusetts, from 1906 to 1957. History In 1906 Philip H. Duprey and Grenville Stoddard established the Worcester Lunch Car and Carriage Manufacturing Company, which shipped 'diners' all over the Eastern Seaboard. It was named for Worcester, Massachusetts, where the company was based. The first manufactured lunch wagons with seating appeared throughout the Northeastern US in the late 19th century, serving busy downtown locations without the need to buy expensive real estate. It is generally accepted that the name "diner" as opposed to "lunch wagon" was not widely used before 1925. The company produced 651 diners between 1906 and 1957, when manufacturing ceased. All of Worcester Lunch Car's assets were auctioned in 1961. Examples Many diners still exist in the Worcester area, including Casey's Diner (1922) in nearby Natick and the Boulevard Diner (1936) in Worcester, which are some of the oldest diners in the country and listed on the National Register of Historical Places. The Miss Worcester Diner (1948) still exists in its original location across the street from the former factory. The Rosebud (1941) is an example at 381 Summer Street in Somerville, Massachusetts near Davis Square. The Elmwood Diner (originally known as Central Diner) is Worcester Lunch Car Company #806 built in 1947 and moved to its current location in 1953 where is still operates in the Elmwood section of Providence, Rhode Island. It was added to the National Register of Historic Places in 2010 Worcester Lunch Car Company #821 is still in its original location at 53 Park Street in Adams, Massachusetts. The former "Miss Adams diner" was sold to a couple in 2013 who operate it as, Izzy's Diner and Pizza, a full service diner and pizza shop, and still contains many original items including the original Worcester Lunch Car Clock. The car is slowly being restored to look as it did originally. While most of their diners were located in New England some were purchased as far away as Florida. The Henry Ford Museum in Michigan contains a notable example of a Worcester Lunch Car diner called Lamy's, built in 1946. In January 2012, Lamy's once again began serving food. Many surviving Worcester Lunch Car diners are currently listed on the National Register of Historic Places. Other examples Maine A-1 Diner, Gardiner, Maine Miss Portland Diner – WLCC No. 818, 1949 Massachusetts Blue Point Restaurant, 6 Dayton Street, Acushnet, Massachusetts Club Diner, Dutton Street, Lowell, Massachusetts Owl Diner, Appleton Street, Lowell, Massachusetts Day and Night Diner, Route 20, Palmer, Massachusetts (Worcester Lunch Car #781, 1944) Dinky’s Blue Belle Diner, Shrewsbury, Massachusetts (Worcester Lunch Car #814) Lanna Thai Diner, Woburn, Massachusetts New Hampshire 4 Aces Diner, Bridge St, West Lebanon, New Hampshire Daddypop's Tumble Inn Diner, Main Street, Claremont NH. Gilleys Diner (1940), Portsmouth, NH Rhode Island Jigger’s Hill and Harbour Diner, Main Street, East Greenwich, Rhode Island Vermont Chelsea Royal Diner, West Brattleboro, Vermont Parkway Diner, South Burlington, Vermont See also List of diners Jerry O'Mahony Diner Company Wilson's Diner References External links Gutman's The Worcester Lunch Car Company Liberty Elm Diner Category:1906 establishments in the United States Category:Diner manufacturers
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Echo in a communication system is commonly characterized as the return of a part of a transmitted signal from an end user back to the originator of the transmitted signal after a delay period. As is known in the art, a near end user transmits an uplink signal to a far end user. Conversely, the near end user receives a downlink signal from the far end user. Echo at the near end occurs when the near end user originates an uplink signal on the uplink path, and a part of the transmitted signal is reflected at the far end as an echo signal on the downlink path back to the near end. Echo at the far end occurs when the far end user originates a downlink signal on the downlink path, and a part of the transmitted signal is reflected at the near end, as an echo signal on the uplink path back to the far end. Typically, the echo delay period corresponds to the round trip transmission time in the communication system plus the dispersion or group delay of the echo generating source. The reflection of the transmitted signal may occur due to a number of reasons, such as an impedance mismatch in a four/two wire hybrid, or feedback from acoustic coupling in a telephone, wireless device or hands free speaker phone. An echo signal corresponding to the delayed transmitted signal is perceived as annoying to the near end user and in some cases can result in an unstable condition known as “howling.” Echo cancellers are required at any echo generating source at both the near end and at the far end in an attempt to eliminate or reduce the transmission of echo signals to the far end and near end. Echo cancelers may be employed in wireless devices, such as cellular phones, car phones, two-way radios, car kits for cellular telephones and other suitable devices. Additionally, echo cancelers may be employed in wireline devices, such as hands free speakerphones, video and audio conference phones and telephones otherwise commonly referred to in the telecommunications industry as plain old telephone system (POTS) devices. Hands free speakerphones typically include a microphone to produce the uplink signal, a speaker to acoustically produce the downlink signal, the echo canceler to cancel the echo signal and a telephone circuit. The hands free speaker phone may be integrated into an in-vehicle audio system. The vehicle may be an automobile, a boat or an airplane, or any suitable vehicle. The in-vehicle audio system may include an amplifier, speakers and an audio source, such as a tuner module, CD/DVD player, tape player, satellite radio, etc. The in-vehicle audio system may be integrated with a communication apparatus, such as a telematics communication module. For example, the telematics communication module may be a component of a General Motors' OnStar system. The telematics communication module typically collects and disseminates data, such as location information and audio, such as speech. Typically, the downlink audio signal received from the far end through the downlink path is played through the at least one speaker in the in-vehicle audio system. However, the hands free speaker phone installed in the vehicle may experience significant coupling between the at least one speaker and the microphone and is referred to herein as an acoustic coupling channel. As a result, an amplified downlink audio signal transmitted through the at least one speaker will be partially received by the microphone as an echo signal. The amplitude of the echo signal referred to herein as the echo return loss depends on the amount of coupling between the at least one speaker and the microphone. Echo cancelers are known to attempt to cancel the echo signals produced at the near end when the far end is transmitting by generating echo estimation data corresponding to a portion of an amplified downlink audio signal traveling through the acoustic coupling channel. The echo canceler generates the echo estimation data through the use of an echo canceler adaptive filter. The echo canceler attempts to subtract the echo estimation data from pre-echo canceler uplink data received from the microphone in order to produce post-echo canceler uplink data. The echo canceler attempts to adapt to changes in the echo return loss by dynamically generating the echo estimation data via the echo canceler adaptive filter. Additionally, attenuators in the uplink path and in the downlink path may also be used to reduce the effect of the echo signals. The echo canceler adaptive filter adapts not only between different calls, but also during a call, due to the nonfixed nature of the acoustic coupling channel between the at least one speaker and the microphone. For example, movement of passengers in the vehicle may affect the acoustic coupling channel and, therefore, the echo canceler attempts to dynamically adapt to the varying echo return loss. However, the pre-echo canceler uplink data may change due to variations in the acoustic coupling faster or beyond the capabilities of the echo canceler adaptive filter. As a result, due to imperfect knowledge of the network medium and the acoustic coupling channel creating the echo signal, the estimated echo data may contain errors. Additionally, if the amplifier gain is increased, the downlink signal may cause the received microphone signal to be so great that the reduced echo return loss may significantly reduce the effectiveness of the adaptive filter and possibly cause the adaptive filter to become ineffective or possibly unstable. Consequently, the adaptive filter under this condition may actually cause the uplink signal to also become degraded, unstable, or corrupted. As a result, the corrupted post-echo canceler uplink data will cause annoying loud noises at the far end. According to one method, the echo canceler attenuates the post-echo canceler uplink data based on the amplitude or power level of the post-echo canceler uplink data in an attempt to attenuate an echo signal transmitted on the uplink path before reaching the far end. However, an increase in the amplitude or power level of the post-echo canceler uplink data may occur due to an increase in the downlink data power and not due to a change in the acoustic coupling channel. As a result, the uplink data may be improperly attenuated causing the near end user not to be heard by the far end user because the echo canceler incorrectly interpreted an increase in post-echo canceler uplink data power due to an increase in downlink data power as an increase in acoustic coupling. According to yet another method, the capabilities of the echo canceler adaptive filter are improved by, for example, increasing a number of coefficients in a finite impulse response filter (FIR). However, since the echo canceler adaptive filter is typically implemented in a processing device, increasing the number of coefficients may result in an increased processor load, and may reduce the rate of adaptation of the echo canceler adaptive filter and increase power consumption. As a result, a more complex and more costly echo canceler adaptive filter is required to satisfy the required processor load.
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WATCH: Super Bowl 2015 Commercials Kim Kardashian, Mindy Kaling, Pierce Brosnan, Katie Couric, Bryant Gumbel, Robert Stromberg and puppies featured in first crop of ads Audiences no longer need to wait until the Big Game to watch Super Bowl commercials, with an increasing number of marketers opting to release their spots days before kickoff. This year is no different, with Budweiser, Budweiser, Bud Light, Kia, Mercedes-Benz USA, T-Mobile, Victoria’s Secret, BMW, even Paramount with “Hot Tub Time Machine 2,” among those having already posted their ads online. The reason? The high cost to play the Super Bowl promo blitz is one. At around $4.5 million per 30 second ad, buying time during the match up between the Seattle Seahawks and New England Patriots is at record levels. NBC is airing the game Feb. 1. An early look at this year’s ads signals that comedy will play a major role after scoring with consumers in previous years. Below is a list of what to expect to see on Super Bowl Sunday: UNIVERSAL’S “FIFTY SHADES OF GREY” Universal made an effort to appeal to the female viewers of the Super Bowl with its “Fifty Shades of Grey” spot while reaching out to males with a kicker of a line referencing Microsoft’s Xbox videogame console. In addition to promoting its “Fast and Furious” theme park attraction, Universal naturally also hyped “Fast 7,” the latest intsallment of the franchise, racing into theaters in April. UNIVERSAL’S “JURASSIC WORLD” Universal unleashed more footage of “Jurassic World” during the Super Bowl, providing a closer look at the dinosaurs that attack theme park visitors in the film, in theaters this summer. UNIVERSAL STUDIOS HOLLYWOOD: “FAST AND FURIOUS – SUPERCHARGED” Universal used the Super Bowl’s pre-game show to promote its new “Fast and Furious” theme park attraction, starring Vin Diesel, Dwayne Johnson, Luke Evans, Tyrese Gibson and Michelle Rodriguez. It also aired a Super Bowl ad for its “Transformers” ride in 2012, and the opening of Wizarding World of Harry Potter in 2010. UNIVERSAL’S “PITCH PERFECT 2” The gang’s all back in Universal’s sequel. UNIVERSAL’S “MINIONS” Turns out the yellow Minions of “Despicable Me” are big fans of the Super Bowl too. SUPERCELL Liam Neeson’s all gruff in a humorous riff on his action roles for mobile gamemaker Supercell in its promotion of “Game of Clans.” Last year, T-Mobile’s Super Bowl ad was text-based and ended with, “Maybe next year, we’ll do an ad with overpaid movie stars.” Kim Kardashian is now that celeb with a spot in which she promotes the cell phone service provider’s Data Stash program, as well as her new book, “Selfie.” In it, she says, “Each month millions of gigs of unused data are taken back by wireless companies. Tragic. Data you paid for that could be used to see my makeup, my backhand, my outfits, my vacations and my outfits. Sadly all lost. Please, help save the data.” T-Mobile already has scored with the spot, which has been viewed over 1 million times. SNICKERS AND “THE BRADY BUNCH” The spot doesn’t include puppies, but there’s Danny Trejo and a very angry Marcia and Jan Brady. PARAMOUNT: “TERMINATOR GENISYS” Arnold Schwarzenegger is back in this attempt to reboot the “Terminator” franchise. KIA, featuring Pierce Brosnan Pierce Brosnan revisits his roles as suave super spy James Bond in Kia’s Super Bowl commercial. The version below is the extended cut of what will air during the Big Game. E!’S “THE ROYALS” Talk about synergy: Comcast is giving E! some airtime during the Super Bowl to promote “The Royals,” which returns March 15. BMW, starring Katie Couric and Bryant Gumbel Built around a segment featuring the former “Today Show” hosts in 1994, in which they couldn’t figure out the @ symbol or needed an explanation of what the Internet was, BMW puts Couric and Gumbel inside it electric i3 and the reaction is just as gee-whiz. DISNEY’S “TOMORROWLAND” Disney released a 10-second teaser for the 30-second ad it will show for the George Clooney film during the Super Bowl. The teaser is followed by the full spot. The sequel, out Feb. 20, is getting a pricey push during the Big Game, with Paramount’s comedy also up against Universal’s “Jurassic World” and “Fast 7” as films that are competing for attention during the Super Bowl. BUDWEISER Budweiser’s “Lost Dog” spot is surely to gain a lot of traction for its cute factor. The company’s Clydesdales are also on watch in supermarkets to make sure shoppers don’t even consider buying a rival brand’s beer in this Super Bowl spot. BUD LIGHT Bud Light built a Pac-Man board the size of a city block for its Super Bowl ad that debuted during “The Tonight Show with Jimmy Fallon.” Last year, it hired Arnold Schwarzenegger to play ping pong. GODADDY.COM GoDaddy’s regular pitch woman Danica Patrick returns for a scant half a second in the company’s Super Bowl spot which resorts to the cuteness of a puppy instead. Update: After public uproar erupted over the spot, it’s been pulled by GoDaddy, with the company saying, “What should have been a fun and funny ad clearly missed the mark and we will not air it,” CEO Blake Irving tweeted. MERCEDES-BENZ USA “Maleficent”-director Robert Stromberg is making his debut as a commercial helmer with Mercedes-Benz with a spot that will air during the fourth quarter and promote its AMG GT. Stromberg’s past work as an art director on “Alice in Wonderland” and “Avatar” is clearly evident in the German automaker’s take on Aesop’s “The Tortoise and the Hare,” with its CG characters and fantasy setting. “We tend to think of fables as things of the past,” Stromberg said of the 60-second spot that took three months to produce and was lensed in Oregon. “It’s fascinating for me to render a classic tale with modern tools, yet keep the message timeless.” DODGE Goes dishes out some wisdom for its brand-based Super Bowl ad. LEXUS Lexus became the first Super Bowl advertiser to offer up its ad — as far back as Jan. 13 — to promote the NX SUV. MOPHIE The maker of cell phone chargers has gone all apocalyptic in its first Super Bowl spot to show how people react when their devices run out of juice. VICTORIA’S SECRET The lingerie brand offers up exactly what you would expect in its Super Bowl spot. DOVE Dove’s Men+Care brand is reaching out to modern men to challenge traditional stereotypes with its “Real Strength” spot. This is the extended cut. ALWAYS After gaining a massive audience online with over 54 million views, Always is airing a shortened version of its “Like a Girl” ad during the Super Bowl.
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Trehalulose (1-O-α-D-glucopyranosyl-D-fructose) is a heterodisaccharide in which glucose and fructose form an α-1,1 bond. It is known as a digestible, non-cariogenic sweetener which has similar physiological properties to isomaltulose. However, the sweetening strength of trehalulose is only 40 to 50% of that of sucrose. According to DE 32 41 788, trehalulose is cleaved only with difficulty by the enzyme system in the human small intestine and is therefore absorbed only partly and at a delayed time. EP 1 424 074 discloses a nutritional composition for controlling the blood sugar level and for preventing obesity, which comprises isomaltulose or trehalulose. EP 1 393 637 A1 discloses agents for improving concentration and attentiveness which, besides isomaltulose, also comprise trehalulose. EP 0 483 755 B1 discloses a process for producing trehalulose and isomaltulose from sucrose. According to the procedure disclosed therein, a sucrose-containing solution is brought into contact with a trehalulose-forming enzyme, and a trehalulose syrup is obtained. The trehalulose-forming enzyme is an enzyme which originates from a microorganism of the genus Pseudomonas or Agrobacterium. The specification discloses that the use of these microorganisms leads to a high trehalulose yield, with only very little monosaccharides being produced as by-products at the same time. In view of the virtually complete conversion, described in this specification, of sucrose to a trehalulose-containing mixture having only approximately half of the sweetness of a comparable sucrose solution, the disclosed trehalulose-containing mixture cannot therefore be used as sucrose substitute in beverages without additional process steps such as the addition of sweeteners. The processes known from EP 0 794 259 B1 for producing trehalulose-containing beverages are accordingly disadvantageous insofar as they provide for the separate addition of further sweeteners in order to obtain a consumable beverage.
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Q: Why is Trump moving to Florida? Donald Trump is moving to Florida. Doesn't he live in the White House in Washington DC? What does it mean that he is moving? Also, do we know why? A: What does it mean that he is moving? He changed his permanent residence from Trump Tower in NYC to Mar-a-Lago in Florida, not actually moving. The change was made September 27th. Also, do we know why? For financial, political and legal reasons. The politics behind Trump's move to Florida are crystal clear, November 2, 2019. Trump has extremely good financial, political and legal reasons to get out of New York: his move is a logical, long-term answer to an immediate set of problems. The transaction itself is straightforward. Trump will almost certainly continue to own his suite atop Trump Tower, and will continue to move between New York and his Mar-a-Lago resort. But by designating Mar-a-Lago as his domicile -- in legal terms, "his true, fixed, permanent home"-- Trump is announcing he will spend most of each year in Florida (when not in D.C.), making him a resident of the Sunshine State for purposes of voting and paying state taxes. By doing so, Trump joins a large exodus of New Yorkers who regularly relocate to Florida for the sunny weather and lower taxes. Florida is considered a swing state. Being a resident may give him more votes. In 2016, Trump carried Florida's 29 electoral votes over Hillary Clinton by a slim 1.2% margin, only about 113,000 votes out of 9.4 million cast. ... The third incentive for Trump to get out of New York is legal. The state Attorney General and the Manhattan District Attorney have launched multiple probes of Trump's businesses, charities, political committees and personal conduct. ... Those inquiries won't vanish for Trump, simply with his moving away, but he knows that New York's overwhelmingly Democratic officials -- including the state attorney general and Manhattan district attorney -- have no incentive to take it easy on him. Trump lives in the White House. So, why is he moving to Florida?, Updated 8:55 a.m. ET Nov. 2, 2019. Trump criticized his political opponents in his “Farewell, New York” tweet Thursday suggesting his decision may have had to do with his treatment by political leaders in the city and state. “Despite the fact that I pay millions of dollars in city, state and local taxes each year,” he tweeted. “I have been treated very badly by the political leaders of both the city and state. Few have been treated worse.” See also Manhattan district attorney subpoena.
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Effect of norepinephrine on cefpirome tissue concentrations in healthy subjects. To test whether norepinephrine (NOR) affects tissue microcirculation and impairs plasma-to-tissue equilibration of antimicrobial agents. Eight healthy male volunteers were enrolled to an analyst-blinded, randomized, two-period two-sequence crossover study. A single intravenous dose of 2 g of cefpirome was administered simultaneously with starting a continuous infusion of NOR (0.16 microg/kg per min) or placebo (PL) over 180 min. The microdialysis technique was used for the assessment of unbound cefpirome concentrations in skeletal muscle tissue and subcutaneous adipose tissue. Free plasma concentrations were related to corresponding tissue concentrations. Haemodynamics were determined by the measurement of mean arterial blood pressure (MAP), heart rate and forearm blood flow (FBF). Area under the concentration-time-curve (AUC) values of cefpirome for interstitium and plasma were not significantly different between the PL and NOR groups (P > 0.47). Tissue penetration of cefpirome as described by the ratios of the AUCs from 0 to 180 min for tissue to the AUC values for plasma were 0.81 +/- 0.34 for the PL group and 0.80 +/- 0.26 for the NOR group (P > 0.05). Baseline values of MAP, heart rate and FBF were not significantly different between study days. MAP increased significantly following NOR administration from 73.3 +/- 3.5 mmHg at baseline to 94.0 +/- 5.2 mmHg during infusion (P = 0.017). NOR exerted no significant effects on FBF. We have shown that intravenous administration of NOR does not exert a significant effect on peripheral blood flow and tissue penetration of cefpirome in healthy men. This might be attributed to systemic regulatory mechanisms, which probably fully compensate for major changes in blood flow in peripheral tissues.
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50 Cal.App.2d 516 (1942) CHARLES TOMAIER, Respondent, v. MILDRED TOMAIER, Appellant. Civ. No. 3011. California Court of Appeals. Fourth Dist. Mar. 17, 1942. Edward M. Selby for Appellant. Alfred Siemon and Bennett Siemon for Respondent. SCHOTTKY, J. pro tem. Appellant wife appeals from a judgment granting respondent husband a divorce upon the ground of extreme cruelty, and making a division of the property of the parties. Appellant contends that the evidence is insufficient to support the finding of cruelty on her part, and that she was entitled to a divorce on her cross-complaint on the ground of desertion. [1] No useful purpose would be served by setting forth the somewhat sordid evidence in the case on the charges of cruelty and on the counter charge of desertion. No hard and fast rule of law can be laid down as to what particular facts must be proved in order to justify a finding that a spouse has undergone grievous mental suffering. A correct decision must depend upon the sound sense and judgment of the trial court. Therefore, in the case at bar, whether or not the acts and conduct of appellant inflicted grievous mental suffering upon respondent was a question of fact for the determination of the trial court from all the facts and circumstances in the case (Barnes v. Barnes, 95 Cal. 171 [30 *518 P. 298, 16 L.R.A. 660]; Hansen v. Hansen, 86 Cal.App. 744 [261 P. 503]; Shaw v. Shaw, 122 Cal.App. 172 [9 PaCal.2d 876]) and a careful reading of the entire record convinces us that there is ample evidence to support the conclusion that respondent was entitled to a divorce upon the ground of extreme cruelty. [2] The trial court found that respondent and appellant were the owners of the following property: Parcel 1. Lots 17 to 21, in Block 99, in the town of Mojave, leased to the Safeway Company and subject to an encumbrance in the sum of $5,000.00. Parcel 2. A residence in Kansas City, Missouri. Parcel 3. Money in escrow in the Bank of America, being the proceeds from the sale of Lot 5, Block 100, in the town of Mojave. Parcel 4. A Dodge, 1939 automobile coupe, house trailer, household furniture and furnishings in possession of respondent at Mojave. The trial court further found that parcels 1, 2 and 3, stood of record in the name of appellant and respondent as joint tenants; and "That the parties acquired said properties during their marriage and that it was not the intention of the plaintiff or of the parties that the defendant should be vested with or become the owner of any interest in either of said properties as her separate property; that said properties and each of them were acquired with separate funds of plaintiff and with community funds of plaintiff and defendant and not with any separate funds of the defendant; that plaintiff never at any time intended to make any gift to the defendant of any right, title or interest in or to any of said properties of either of them; that the interest in said properties which these parties now own was acquired by them with the purpose and intention that the same should be and become their community property; that the parties agreed to encumber and did encumber said properties for the improvement of the same for their common benefit and they agreed that the community income should be applied to the improvement and development of said properties for their common use and benefit and that they never had any intention that said properties or any of the same should be improved or developed or acquired for the benefit of the separate estate of the defendant; and that the property referred to as parcel 4 is personal property and the community property of the parties hereto." The trial court then decreed that all of said property was *519 community property and awarded parcels 1 and 4 to respondent, parcel 2 to appellant, awarded appellant $1000.00 out of parcel 3, and respondent the balance of parcel 3, and awarded appellant $1850, to be paid by respondent at the rate of $50.00 per month, commencing at the entry of the final decree, without interest. Appellant contends that the trial court erred in finding that parcels 1, 2 and 3 were community property, and argues that because said real property stood in the names of appellant and respondent as joint tenants, this finding cannot be sustained. We must agree with this contention and hold that the trial court had no power to divide the property held in joint tenancy as though it were in fact community property. This is clearly held by our Supreme Court in Siberell v. Siberell, 214 Cal. 767 [7 P.2d 1003], there the court said, at page 773: "First, from the very nature of the estate, as between husband and wife, a community estate and a joint tenancy cannot exist at the same time in the same property. The use of community funds to purchase the property and the taking of title thereto in the name of the spouses as joint tenants is tantamount to a binding agreement between them that the same shall not thereafter be held as community property but instead as a joint tenancy with all the characteristics of such an estate. It would be manifestly inequitable and a subversion of the rights of both husband and wife to have them in good faith enter into a valid engagement of this character and, following the demise of either, to have a contention made that his or her share in the property was held for the community, thus bringing into operation the law of descent, administration, rights of creditors and other complications which would defeat the right of survivorship, the chief incident of the law of joint tenancy. A joint tenancy in one estate and in it the rights of the spouses are identical and coextensive." "Secondly, on its face section 164 has no application to a case where 'a different intention is expressed in the instrument' and it seems to us clear, as already pointed out above, that a joint tenancy, the evidence of which the law requires to be on the face of the conveyance creating it, is of necessity an expression of the intention to hold the property otherwise than as community property and that the equal interest *520 of the spouses must therefore be classed as their separate but joint estate in property." (See, Estate of Harris, 9 Cal.2d 649 [72 PaCal.2d 873].) Furthermore, we deem it proper to state that there is no evidence in the record that it was the intention of the parties that the property should be held other than in joint tenancy, so even if it were proper in such a case to show that there was such an intention, which we do not hold, there is no evidence to support it. In view of the foregoing, that part of the judgment granting respondent an interlocutory decree of divorce upon the ground of extreme cruelty is affirmed, and that part of the judgment as to the division of the property is reversed. Costs of appeal to be borne by each party. Barnard, P. J., and Marks, J., concurred.
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Q: How to a warp cause another warp be in the Idle state? As you can see in the title of the question, I want to know how a warp causes another warp go to the Idle state. I read a lot of the Q/A in the SO but I can not find the answer. At any time, just one warp in a block can be run? If so, the idle state of warp has no meaning, but if we can run multiple warps at the same time each warp can do their work separately to other warps. The paper said: Irregular work-items lead to whole warps to be in idle state (e.g., warp0 w.r.t. warp1 in the following fig). A: The terms used by the Nsight VSE profiler for a warp's state are defined at http://docs.nvidia.com/gameworks/index.html#developertools/desktop/nsight/analysis/report/cudaexperiments/kernellevel/issueefficiency.htm. These terms are also used in numerous GTC presentation on performance analysis. The compute work distributor (CWD) will launch a thread block on a SM when all resources for the thread block are available. Resources include: thread block slot warp slots (sufficient for the block) registers for each warp shared memory for the block barriers for the block When a SM has sufficient resources the thread block is launched on the SM. The thread block is rasterized into warps. Warps are assigned to warp schedulers. Resources are allocated to each warp. At this point a warp is in an active state meaning that warp can executed instructions. On each cycle each warp scheduler selects from a list of eligible warps (active, not stalled) and issues 1-2 instructions for the warp. A warp can become stalled for numerous reasons. See the documentation above. Kepler - Volta GPUs (except GP100) have 4 warps schedulers (subpartitions) per streaming multiprocessor (SM). All warps of a thread blocks must be on the same SM. Therefore, on each given cycle a thread block may issue instructions for up to 4 (subpartition) warps in the thread block. Each warp scheduler can pick any of the eligible warps each cycle. The SM is pipelined so all warps of a maximum sized thread blocks (1024 threads == 32 warps) can have instructions in flight every cycle. The only definition of idle that I can determine without additional context are: - If a warp scheduler has 2 eligible warps and 1 is selected then the other is stalled in a state called not selected. - If warps in a thread block execute a barrier (__syncthreads) then the warps will stall on the barrier (not eligible) until the requirements of the barrier are met. The warps are stalled on the barrier.
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Q: Include QT file problem in Visual Studio 2008 When I type #include <QObject> it complains that it couldn't find file. but if I type #include <QtCore\QObject> It works properly. I moved VS2005 to VS2008, this was not the case in VS2005, and it started with VS2008. Why am I getting this error? A: Actually it's not so big problem. You need to check you include directories and add (path_to_qt_headers)/QtCore, (path_to_qt_headers)/QtGui and directories for other modules you are using. According to your problem description you have added only (path_to_qt_headers) itself. If Qt set up correctly both #include <QObject> and #include <QtCore/QObject> should work but second one works in more cases. I remember I saw some notice somewhere in the Qt documentation that it might be better to using second include style. At the same time this long include version is recommended in the KDE coding guidelines. For myself I preffere to follow #include <QtModule/QClass> include convention
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When the Bengals selected Jessie Bates in Round 2 of the 2018 NFL Draft, the team knew it was getting a smart, talented safety who could come in and elevate the defense starting on Day 1 of his rookie year. Why? Because Bates has the playmaking ability the Bengals lacked in 2017 and the football IQ needed to not only make it in the NFL, but elevate his teammates when on-the-field. That football IQ is a big reason why Bates felt comfortable declaring for the draft following his redshirt sophomore season at Wake Forest, a year in which he had 77 tackles (6 for loss), 1 interception, 6 batted passes and 1 forced fumble. His 2016 season was maybe even more impressive as he racked up 100 tackles (3.5 for loss), 5 interceptions (2 of which went for touchdowns), 4 batted passes and 1 forced fumble. “I felt I had the best football IQ out of not only the safeties but the whole draft,” Bates said in an exclusive interview with Cincy Jungle. “It’s something I’m very comfortable with and confident in as I get into different systems. I think my football IQ has helped me a lot with the success I’ve had so far.” Bates made an immediate impact at Wake Forest and was runner up as Rookie of the Year in the ACC in 2016. His talents extend to special teams, too, where he recorded 27 punt returns for 234 yards (8.7 yard per return average) and 1 touchdown. That touchdown — a 59-yard return — was timely as it came in Wake Forest’s bowl game against Texas A&M, Bates’ final collegiate game. Wake Forest won the game and Bates had 6 tackles in addition to the special teams touchdown, capping off an impressive college career. Interestingly for the Fort Wayne, Indiana native, the Bengals’ first game of the 2018 regular season will come against the Indianapolis Colts. The trip from Fort Wayne to Indianapolis is about two hours, which will be an easy ride for Bates’ family and friends. That game will also be preceded by a preseason finale against the Colts in Cincinnati. “First thing all my friends and family talked about after I was drafted was my first official game being at Indianapolis,” Bates said. “That’ll be pretty cool for me and my family members and friends.” While Wake Forest was an eight-hour drive from Bates’ hometown, he’ll now be a short distance from home in Cincinnati — there’s a 35-minute flight, or it’s a three-hour car ride. And he’s expecting his best friend, a big football fan, to be visiting frequently. Who’s his best friend, you ask? His mother, Theresa Ladd! “She’s my mom, my coach, my best friend. All the above,” Bates said of his relationship with his mother. “She’s just amazing and I feel like if people met her they’d understand why. Our relationship is really close and she gives me purpose. When things get hard, I think of her. She’s my motivation and really important to me and my football career.” It’ll surely be nice to have that motivation nearby as Bates adjusts to life in the NFL. Though, it sounds like he’s going to fit in with his new teammates just fine. “I would say I’m most excited to intercept Ben Roethlisberger,” Bates said. “That’s probably most important, I think, that I pick off that guy. The Steelers have always been a powerhouse and now, for us, they are a rival. Rivalry games are the best games to play in and the Steelers have a lot of talent, a lot of guys I’ve watched every Sunday for years. Being able to compete against those guys is something I look forward to.” Bates is also looking forward to learning from his teammates, including fellow safeties Shawn Williams and George Iloka. “I think they’re both really good safeties,” Bates said. “They’re way more stockier, big hitters. I’m looking forward to working with them and know they’re going to help me. I’m really interested in building those relationships. I know they’re vets and have been there for a long time. I’m just going to try and learn and make each other better.” Bates measures in at 6’1”, 200 pounds, compared to Iloka who is 6’4”, 225 and Williams who is not much bigger than the rookie at at 6’, 210. Ahead of arriving in Cincinnati on Thursday for rookie minicamp, Bates had not yet spoken to many of his new Bengals teammates. Cornerback KeiVarae Russell did reach out to him as the two have a friend in common in Cowboys linebacker Jaylon Smith, who is also from Fort Wayne. Smith actually joined Bates to celebrate after the draft. “It seems like they’re all very welcoming and everyone is excited to work with each other,” Bates said. “I’m just very excited to learn with one another and build those relationships.” Bates is realistic about his expectations with the Bengals this year but no matter what, he wants to have an impact. “I feel like you cant set a goal until you know your role,” Bates said. “Once I get there and see what my role is, then I’ll set goals. But if my role is to be a special teams player, my goal will be to make an impact as a special teams player and play to the best of my ability. Or, if it’s just playing on third down, I’ll try to turn the ball over on third down. Or if it’s all three downs, try to be consistent at what I do and again, turn the ball over. So whatever it is, my goal will be to make an impact, wherever my role is.” Bates knows the Bengals lacked turnovers last year; the team had only 14 turnovers in 2017, which ranked second to last in the NFL. That’s not going to cut it if Cincinnati wants to return to the playoffs in 2018. “I think I can bring turnovers, which they lacked lat year, that’s the No. 1 thing,” Bates said of what he hopes to bring to the team. “But also competition to the defensive back room. To push not only myself but my teammates as well. Being able to compete and make the room better. I’m always going to be around the ball. Doing my job and communicating with the whole defense.” It sounds like the Bengals have a player with a winning attitude in Bates; it’s going to be exciting to see him on-the-field in Bengals stripes for years to come. “I’m ready to put my head down and not say too much, just get to work,” Bates said. “I want to help get the Bengals back on track and I’m really excited to not only play football but give back to the community and build relationships with the fans, players, coaches and community.”
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Protein engineering of aldolase LbDERA for enhanced activity toward real substrates with a high-throughput screening method coupled with an aldehyde dehydrogenase. A new high-throughput method for screening 2-deoxyribose-5-phosphate aldolase variants with a higher activity toward aldol reaction of unnatural aldehydes was established for the first time by coupling with an aldehyde dehydrogenase LeADH. The error-prone PCR and site-directed saturation mutagenesis libraries of aldolase LbDERA were constructed and screened using the high-throughput method. Two improved variants, LbDERAT29L and LbDERAF163Y, were identified and combined, giving a double mutant LbDERAT29L/F163Y which showed 7-fold higher activity than the native enzyme. The crystal structure of LbDERAT29L/163Y obtained by X-ray diffraction with 1.77 Å resolution revealed the structural changes responsible for the significant activity improvement.
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In her most excellent trolling of Donald Trump and the reactionary tendency he represents the High Priestess of Tinsel Town, Meryl Streep, showed her own haughty disdain for a significant chunk of American society, the sporting community. Her Golden Globes address hit so many top notes the high-handed dismissal of football (American) and Mixed Martial Arts (MMA) jarred, revealing a casual prejudice not only against the sports identified but those who like to watch them. Given the popularity of gridiron, the most viewed sport in America, that is an almost Trump-like disregard for the legitimate interests of those she doesn’t understand. It also flagged the kind of detached, contemptuous attitude of the elites towards blue collar America that allowed Trump through the White House door in the first place. Soaring Moral Abhorrence “So Hollywood is crawling with outsiders and foreigners, and if you kick ’em all out, you’ll have nothing else to watch but football and mixed martial arts, which are not the arts,” said La Streep. It was a fine speech, full of soaring moral abhorrence of the monstrous Trump, and who in their right mind does not feel that? But why empty her bladder on sport as if it were some kind of swamp activity for unthinking nomarks. Let me tell you, Meryl, there is no escape route in your country that is more inclusive than gridiron, that has given the disenfranchised and marginalised black American a shot at the privileged existence you enjoy. I’m sorry the participants and many of those they engage so powerfully are not members of book clubs, regular theatre goers or fine art aficionados. This ghastly rabble, or ‘deplorables’ as one member of America’s political elite once described them, are welcome enough, no doubt, when they turn up at a cinema with their sugary drinks and popcorn to help fill your coffers. But then they stop where the red carpet starts. Luvvie Love-in Season Maybe I’m a little oversensitive, groaning at the start of the annual luvvie love-in season, when the great and the good of the performing arts spread their peacock feathers on the highest stage and pontificate downwards to the great unwashed. I mean, the cheek of it, this put-upon constituency of troubadours grouping themselves with Trump’s foreigners and the Press as the most vilified in society. Meryl was borrowing from Hugh Laurie of House fame, with that reference, a man who learned all he knows about life in the margins while slumming it at Eton and Cambridge. We’ll be sending food parcels next to Malibu and Beverly Hills, the poor little darlings. The other contradiction in Streep’s condescension toward the jocks of this world is how well Hollywood has done out of the sport genre. Most of those applauding Meryl in the LA audience think Rocky Balboa is the most famous fighter to come out of Philadelphia. Pioneering Souls Indeed the steps leading up to the Museum of Art are among the city’s most famous landmarks, not as a result of any exhibits inside but because Sylvester Stallone galloped up and down them in his sweatpants. Sport address issues, too, and importantly at grassroots level led by pioneering souls who earn not a bean for their contribution. So when the great Meryl is up on that stage amplifying the magnificent work actors do in “entering the lives of people who are different from us, and let you feel what that feels like…breathtaking, compassionate work,” it is worth noting that there are thousands of volunteers with a whistle in their hands teaching kids how to be good citizens through engagement in sport. The difference is they aren’t given a platform to project their values and their worth to the world. They just get on with it. Yes, you are right, Meryl, that’s not art, it’s life. And in many cases, a life saver. iNews https://inews.co.uk The i newsletter News for open-minded people. Delivered straight to your inbox. Email address: By entering your email address and clicking on the sign up button, you are agreeing to receive the latest daily news, news features and service updates from the i via email. You can unsubscribe at any time and we will not pass on your information. We know that sometimes it’s easier for us to come to you with the news. That's why our new email newsletter will deliver a mobile-friendly snapshot of inews.co.uk to your inbox every morning, from Monday to Saturday. This will feature the stories you need to know, as well as a curated selection of the best reads from across the site. Of course, you can easily opt out at any time, but we're confident that you won't. Oliver Duff, Editor By entering your email address and clicking on the sign up button below, you are agreeing to receive the latest daily news, news features and service updates from the i via email. You can unsubscribe at any time and we will not pass on your information. By entering your email address and clicking on the sign up button, you are agreeing to receive the latest daily news, news features and service updates from the i via email. You can unsubscribe at any time and we will not pass on your information.
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John Weale (Royal Navy officer) Rear Admiral John Stuart Weale, (born 14 July 1962) is a Royal Navy officer who serves as Flag Officer Scotland and Northern Ireland, Assistant Chief of Naval Staff Submarines and Rear Admiral Submarines. Early life Weale was educated at St Augustine's College in Thanet, the University of Westminster and the Royal Naval College, Dartmouth. Naval career Weale joined the Royal Navy in 1985. He became commanding officer of the submarine in 1999 and then became Operations Officer in the aircraft carrier in 2006 in which role he took part in the evacuation of UK citizens during the 2006 Lebanon War via Cyprus. He went on to be Chief of Staff to Combined Task Force 158, a naval task force operating in Iraqi waters, in 2008, Commander of Sea Training North in 2010 and Deputy Flag Officer Sea Training in 2012. He became Flag Officer Scotland and Northern Ireland and Assistant Chief of the Naval Staff Submarines in July 2015 and, additionally, Rear Admiral Submarines in October 2015. Weale was appointed an Officer of the Order of the British Empire in the 2009 Birthday Honours, and a Companion of the Order of the Bath in the 2019 New Year Honours. References Category:1962 births Category:Companions of the Order of the Bath Category:Living people Category:Officers of the Order of the British Empire Category:Royal Navy admirals Category:Royal Navy personnel of the Iraq War
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Mr Robinson and the team from the BBC, including scholar and historian Michael Jones, were making a program called Britain's Real Monarch.Dr Jones had discovered strong proof that the 15th-century English monarch Edward IV was illegitimate, thus throwing into question the legitimacy of all the kings and queens who followed. It appeared that the royal line should have extended not through Edward, but through his brother George, Duke of Clarence, and his heirs. "They arrived here and filmed my surprise as they put the family tree down on the table," recalls Mr Hastings. Dr Jones told him he believed Edward IV was the illegitimate son of an archer. "His parents were 200 miles apart at the time he was supposed to have been conceived," says Mr Hastings. "The crown should have gone to Edward's brother George, Duke of Clarence, which is our line of the family." The lie was perpetuated for more than 500 years and Mr Hastings, descended from a Catholic Plantagenet on the losing side of the civil wars of the 15th century, has been denied his throne. "Who would bloody well want it, anyway?" asks the man who should be known as King Mike I. "I feel sorry for poor old Liz. I think she has a very hard life because it is so regimented. I do what I want, but if Liz wants to sit in and watch Fawlty Towers on TV, she can't." The revelation has changed some things for Mr Hastings. He has received a proposal of marriage. "Some mad tart down in Melbourne wrote to me and wanted to marry me," said the king, who has received thousands of letters since the ABC screened the documentary in May 2004. "I haven't replied to one." The revelations crystallised Mr Hastings' thoughts on his adopted country and he is now a staunch republican. The publicity also generated a personal call from the NSW Minister for Citizenship, Gary Hardgrave. "He called and asked if I would be interested in taking out citizenship. It was really pure laziness, I just hadn't got round to filling out the damn forms. "I consider myself an Aussie, I cheered for Australia during the Ashes and even bet a slab on it with my brother-in-law in England." Mr Hastings is also the 14th Earl of Loudoun and has passed on to his daughters a castle, manor house and gatekeeper's lodge at the family's Leicestershire seat of Ashby-de-la-Zouch. Donnington Hall in Leicestershire and Loudoun Castle in Scotland have been sold off to pay death duties. "I take my title very seriously indeed, but the thing about being the King is a bit of a joke." In Jerilderie, his old maroon Falcon attracts plenty of waves from his neighbours, but that has more to do with his roles on the Shire Council, Historical Society and Football Club than his lofty title. At the Jerilderie Motor Inn, owner Bruce Crittenden insists that the 1000-strong population has been unaffected by the discovery of blue blood in their midst. "We just call him 'Kingsy' if we see him in the street," says Mr Crittenden with a laugh. A triple-heart bypass operation earlier this year gave Mr Hastings time to reflect on the events of his life. After attending the elite Ampleforth school with Andrew Parker Bowles, the first husband of Prince Charles' wife, Camilla, ("a bloody nice bloke, by the way") Mr Hastings headed to Australia in 1960. "Me and my mate started selling Encyclopedia Britannicas in Bondi, but it was so hot carrying the bloody things around that we started going in the pubs, " he recalls. "We got so drunk that we couldn't remember which one we left them in." Instead, he headed out bush to a life as a jackaroo. He met wife, Noelene, by chatting her up as she operated the switchboard on the local telephone exchange. Eventually they settled in Jerilderie, 60 kilometres north of the Victorian border. The couple had five children and shared no inclination to return to England. In 2002, Mr Hastings had his annus horribilis, with the death of Noelene from breast cancer, as well as the deaths of his mother and stepfather. "I went back with my daughters and used my Earl title. It is the best way to get attention in the old country." But the true King of England found he did not like the class system and was glad to return home to his job with Rice Research Australia. "I am a republican. I think we have progressed long enough and far enough to stand on our own two feet. "Now that might be a job I could do — "I could volunteer to be Australia's first head of state."
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Is tranexamic acid safe in patients undergoing coronary endarterectomy? Patients undergoing coronary endarterectomy during coronary artery bypass grafting (CABG) are at increased risk of perioperative myocardial infarction due to coronary intimal disruption. Data assessing the safety of the antifibrinolytic drug tranexamic acid (TA) in patients undergoing this procedure are lacking. From September 1997 to December 1999, 221 patients underwent nonemergency primary CABG with endarterectomy of the right coronary artery alone in 149, the left anterior descending in 35, or both right and left anterior descending in 27. TA was administered intraoperatively to 87 patients (TA group: average total dose 62 +/- 4.4 mg/kg; range 20 to 109 mg/kg), and was not administered to 134 patients (No TA group). The patient characteristics of the 2 groups were similar. In-hospital mortality consisted of 2 patients in the TA group and 4 patients in the No TA group. Perioperative myocardial infarction rates were 2% and 5% in the TA and No TA groups, respectively (p = 0.49). The relative risk for any type of perioperative cardiac ischemic event in the TA group versus the No TA group was 0.77 (95% CI; 0.4, 1.2). Patients in the TA group had a significant reduction in postoperative chest tube drainage (685 versus 894 mL in the TA versus No TA groups, respectively) and in the use of fresh-frozen plasma (p = 0.03). These results suggest that the clinical effectiveness of tranexamic acid in reducing postoperative blood loss in patients undergoing coronary endarterectomy is not associated with a higher incidence of myocardial ischemia-related complications.
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Las Vegas NHL Expansion Team Hires Assistant GM Las Vegas NHL Expansion Team Hires Assistant GM Las Vegas NHL Expansion Team Hires Assistant GM A couple of weeks ago, the Las Vegas NHL expansion team announced the hiring of George McPhee as the team’s first general manager. On Tuesday, the team announced McPhee’s first hire since joining the team, naming Kelly McCrimmon the assistant general manager. As the team begins to build onto their management structure, they add someone with a lot of hockey experience, although it came in the minor league and not the NHL. He began as a player for the Brandon Wheat Kings, but quickly moved to the assistant coach of the team in 1988. Since then, he has grown to be the team’s head coach, general manager and owner. Under McCrimmon, the Wheat Kings have become one of the most successful franchises in all of junior hockey. With the team, McCrimmon was named the executive of the year a total three times in the Western Hockey League. He will look to continue that success into the NHL with their newest franchise in Las Vegas. The Las Vegas NHL expansion team, which doesn’t officially have a name yet, are set to begin league play for the 2017-2018 season. This doesn’t give the team — and right now, more specifically McCrimmon and McPhee — a lot of time to start putting the pieces to the puzzle together. Not only do they need to finish filling out their staff and personnel sheet, but they also need to start thinking about who they want to fill out their roster. [AdSense-A] The NHL will enter an expansion draft next June, which will allow the team to put together a roster to play with. So, how will the draft work? Well, Las Vegas will get to choose one player from each NHL franchise. However, each club will have the opportunity to either protect seven forwards, three defensemen and one goaltender OR eight total skaters and one goaltender. Any player on the protected list won’t be able to be drafted by Las Vegas. In addition, players that are in their first or second year, as well as unsigned draft choices, will be exempt from the expansion draft. For a full list of the requirements and rules for the 2017 NHL expansion draft, click here. Following the expansion draft, Las Vegas will also take part in their first NHL draft of young players, which will give them a chance to find some franchise players for years to come. For a new team, that’s always a must. Las Vegas will join the Pacific Division as the eighth team and will join the Western Conference as the 15th team. Currently, the Eastern Conference has 16 teams, making a total of 31 teams. Stay tuned for more information and signings for the NHL’s newest team in Las Vegas.
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Contraceptive sterilization use among married men in the United States: results from the male sample of the National Survey of Family Growth. Surgical sterilization has many advantages. Previous information on prevalence and correlates was based on surveys of women. We estimated the prevalence of vasectomy and tubal ligation of partners for male participants in the 2002 National Survey of Family Growth, a nationally representative survey of US residents aged 15-44 years. We identified factors associated with sterilizations using bivariate and multivariate techniques. The findings revealed that 13.3% of married men reported having had a vasectomy and 13.8% reported tubal sterilization in their partners. Vasectomy increased with older age and greater number of biological children, non-Hispanic white ethnicity, having ever gone to a family planning clinic. Tubal sterilization use was more likely among men who had not attended college, those of older age and those with live births. One in eight married men reported having vasectomies. Men who rely on vasectomies have a somewhat different profile than those whose partners have had tubal sterilizations.
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The GABA(a) receptor complex in the developing chick optic tectum: Ontogeny of [(3)H]muscimol, [(3)H]flunitrazepam and [(35)S]TBPS binding sites. The developmental profiles of the neurotransmitter recognition site, labeled by [(3)H]muscimol, and of the two main modulatory sites, labeled by [(3)H]flunitrazepam and [ (35)S ]t- butylbicyclophosphorothionate , respectively, within the GABA(A) receptor complex, have been determined in chick tectal lobes between embryonic day 8 and postnatal day 20. The consonance among the rates of appearance and accumulation of the three receptor sites in tectal membranes suggests a coordinated expression and assembly of the protein subunits involved in the spatial configuration of the complex and its three binding sites, although the existence of isolated muscimol binding subunits during early embryogenesis cannot be excluded at the present time. Furthermore, the total number of binding sites of each kind, per pair of lobes, is compatible with a 1/1/I stoichiometry. The GABA(A) receptor complex reaches a maximum of expression, relative to total membrane protein, immediately after hatching, suggesting that the tectal GABAergic system may be instrumental in damping the effects of sudden exposure to light of the chick visual system upon eye opening.
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PINEHAVEN COUNTRY CLUB The perfect place to play with friends & family! The Dreams of Eleven Sportsmen Pinehaven as you see it today is the result of those dreams. Carved through the pine barrens of the Historic Pine Bush Area of Albany County, it is truly a setting of magnificent beauty. Pinehaven’s impeccable course conditions and six sets of tees, provides a great experience for golfers of all ages and skill levels
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Michigan State UniversityMichigan State UniversityCloseMenu buttonMenu and Search buttonOpenCloseNewsVideoEventsresourcesnewsletterExpertsProgramsYouTubeFacebookTwitterGoogle PlusAsk an ExpertSee how spartans make a difference in Michigan. MI Spartan Impact SE Michigan regional report for May 5 Editor’s note: This article is from the archives of the MSUCrop Advisory Team Alerts. Check the label of any pesticide referenced to ensure your use is included. Weather and insect activity Southeast Michigan has experienced very warm temperatures over the past two weeks. On several dates, temperatures were in the mid-70s, and reached into the 80s on one day. Nearly three inches of rain fell in the same time period. Field operations have generally been taking place without major problems, but many fields have standing water today after over one and one-half inches of rain on Sunday, May 2, and heavy rain is forecast for later today. On April 28 and 29, temperatures dropped to freezing or near freezing in Southeast Michigan. There is a great deal of insect activity with the warm weather, but no significant damage has occurred on the cole crops and sweet corn that has been planted. Adult armyworm and black cutworm activity has been reported from locations in southern Ohio. Flea beetles are evident now in cole crop plantings. We may see problems with Stewart’s wilt due to a relatively mild winter and likely higher survivorship of corn flea beetle adults. Crop report Cabbage, broccoli, and cauliflower transplants have been in the field now for several weeks at most locations. Warm weather and adequate rainfall have given these transplants a good start. Sweet corn has been planted now in many locations, and emergence has occurred. Growers were concerned about frost last week, but I have not seen any damage in sweet corn plantings.
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Q: How can I make 8-bit style graphics in Fireworks? I use Fireworks and want to create 8-bit style graphics, kind of like the games on the NES. What are the best methods for this? Can I reduce the colour palette? What about the number of pixels, is there a difference here? Or, should I just take my full quality graphics and save as an 8-bit PNG? Any advice and/or further reading would be most appreciated. A: I am not an expert on this, so take with a grain of salt. But why not research how you might make graphics if you were working with the tools of the era? If you were using Deluxe Paint for the Amiga? While making a slick vector and then downsampling on export might work, it might be better to pick your 256 colors and build your image pixel by pixel. Or, perhaps you could find some screenshots of the NES games you want to emulate. You can then sample the palette to see what kind of colors you can work with, and you can take a close look at the sprites that they have to see how the graphics were made. Megaman in particular had very expressive character sprites, even though they were just a few pixels tall compared to today! The look and feel of Mario is the first thing that lots of people would think of when you think "8-bit," so if you want to evoke the feel, print some screenshots and keep them on your desk as you create.
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Q: Simple maths - rearranging terms I have a formula: $$\frac{\sqrt{\frac{2Ka}{h}}}{a}$$ How can it be arranged as: $$\sqrt{\frac{2K}{ah}}$$ I only can do: $$\frac{\sqrt{\frac{2Ka}{h}}}{a}$$ $$=\sqrt{\frac{2Ka}{h}}.\frac{1}{a}$$ $$=\frac{2Ka}{h}.\frac{1}{a^2}$$ $$=\frac{2K}{ah}$$ which is not correct, anyone help please? A: Write $a = \sqrt{a^2}$ and use the fact that $\sqrt{x/y} = \sqrt{x}/\sqrt{y}$ when $x, y > 0$. (I am assuming $a, h, K$ are positive) So $$\frac{\sqrt{\frac{2Ka}{h}}}{a} =\frac{\sqrt{\frac{2Ka}{h}}}{\sqrt{a^2}} = \sqrt{\frac{(\frac{2Ka}{h})}{a^2}} = \sqrt{\frac{2K}{ha}} $$ A: When $a$ is positive you can do $a=\sqrt{a^2}\;$ and you get $$\frac{\sqrt{\frac{2Ka}h}}a=\frac{\sqrt{\frac{2Ka}h}}{\sqrt{a^2}}=\sqrt{\frac{\frac{2Ka}h}{a^2}}=\sqrt{\frac{2Ka}{ha^2}}=\sqrt{\frac{2K}{ha}}$$ A: There is a subtle distinction here that many students miss. If I have an equation like $x = y$, then it is valid to square both sides and conclude that $x^2 = y^2$. Notice there are two sides of the equation to manipulate, so it makes sense to manipulate them simultaneously. The use of the equals sign here is to indicate that there are two different quantities, but they happen to have the same numerical value. Your initial question is to simplify a single expression having no equals sign. Your use of the equals sign here is meant to indicate that you have multiple ways of writing your single initial quantity. There are not two different quantities in balance, so there is no sense in which you may "square both sides". What sides? There is only one quantity. The point of all that is to say that you went awry at the second to last line. Squaring a single quantity changes that quantity. If you want to bring the $\frac{1}{a}$ into the radical, try rewriting it as $\sqrt\frac{1}{a^2}$.
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Adopted by House 3-10-2010 SB42 HFIN AMT 3-5McOS. B. 42 -- "A BILL to amend and reenact §8-38-3, §8-38-4, §8- 38-5, §8-38-7, §8-38-10, §8-38-12, §8-38-15, §8-38-16, §8-38-17 and §8-38-20 of the Code of West Virginia, 1931, as amended, all relating to revising the Municipal Economic Opportunity Development District Act generally; enlarging the types of municipal corporations that may use sales tax increment financing to finance certain economic development projects to any Class I, Class II and Class III city and any Class IV town or village; including remediation of former coal mining sites as a permissible development expenditure for a project; changing standard by which the maximum amounts of reserves that may be established in the financing of a project are measured; suggesting that the development office should consider whether the economic development that a project enables is large enough to require that it contain mixed use development consisting of a housing component with at least ten percent of housing units in the district allocated for affordable housing when determining whether there is a pressing need for the project; defining affordable housing; and allowing the development office to reduce the minimum amount of local sales tax revenues that would be deposited into the state's general revenue fund in certain circumstances.".
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Robbins lemma In statistics, the Robbins lemma, named after Herbert Robbins, states that if X is a random variable having a Poisson distribution with parameter λ, and f is any function for which the expected value E(f(X)) exists, then Robbins introduced this proposition while developing empirical Bayes methods. References Category:Statistical theorems Category:Lemmas Category:Poisson distribution
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Monday, December 17, 2018 Australia's parliament has published a report on organ trafficking in Australia. They didn't find much trafficking there, but recommend that data be more vigorously collected. They report that only one case of (attempted) paid organ donation has come to the attention of the authorities, but that it was successfully prevented, and the intended recipient died. The report ends with a case study of an anatomical exhibit using human cadavers. "This report examines the global prevalence of human organ trafficking and the scope of Australian participation within this illicit trade. ... "2.5...The commercial trade in human organs is near-universally prohibited. Despite these prohibitions and restrictions, the illicit commercial trade in human organs has been estimated by the research advisory organisation Global Financial Integrity to be worth between US$840 million and $1.7 billion globally each year.4 Up to 10 per cent of kidney transplants worldwide may now involve commercially traded organs. ... "3.15 There has been only one reported case to date of alleged organ trafficking within Australian jurisdiction,Alleged case of organ trafficking in Australia "In 2011, an Australian couple were alleged to have brought a woman from the Philippines to Australia, promising her monetary compensation and a working visa in exchange for a kidney donation. The woman changed her mind upon arriving in Australia. Medical transplant integrity procedures – a pre-operative counselling session at a Sydney hospital –ensured that the situation was discovered before the removal of the organ. The potential donor was identified as an alleged victim of organ trafficking, resulting in referral to the Australian Federal Police. Due to the death of the prospective recipient, and limitations of the legislation as then in force, the matter did not progress to prosecution." ... "3.20 International studies have observed the tendency of patients born in a country where organ trafficking may occur, but living outside of that country, to be at a substantially higher risk of participation in transplant tourism.31 This would appear to be equally true in Australia, as Dr Campbell Fraser observed: "...less than five per cent of Australians who are waiting on organs are likely to even consider going overseas. ...most of the Australians who have purchased an organ overseas have ethnic family connections to the countries or regions where they buy their organs—Pakistani Australians tended to go to Pakistan, Egyptian Australians travel to Egypt, and so on." ... "Mandatory reporting by medical practitioners 3.41 A large number of submissions and witnesses argued in favour of the establishment of a nationwide mandatory reporting scheme for commercial transplants. A Bill before the Parliament of New South Wales, Human Tissue Amendment (Trafficking in Human Organs) Bill 2016, introduced by Mr David Shoebridge MP, seeks to amend the Human Tissue Act 1983 (NSW). The amendment would, inter alia, require medical professionals to report to the NSW Secretary of Health any reasonable belief that a patient has received a commercial transplant or one sourced from a non-consenting donor. ..."Case study on alleged human tissue trafficking ‘Real Bodies’ 6.1 The Real Bodies commercial anatomical exhibition, on display in Australia during the course of this inquiry, was brought to the attention of the Sub-Committee by a number of witnesses and is illustrative of an apparent gap in the current legislation. The Real Bodies exhibition involves the commercial display of 20 plastinated human cadavers, and ‘over 200’ plastinated organs, embryos and foetuses.1Allegations of the trafficking of organs and other human tissue 6.2Mr David Shoebridge MP of the New South Wales Parliament informed the Sub-Committee as to the nature of the exhibition:... "[they] are real bodies ... they are displayed in quite grotesque circumstances—some of them literally sawn down the middle and presented as a human standing and divided in two so that you can look into the internal parts of them. There are pregnant women. There are multiple fetuses ... put on display for commercial gain ... it is a grossly exploitative process. The proprietors ... have been asked about the circumstances in which these bodies came into their possession, and they have been unable and unwilling to prove that any of the persons on display ever gave their consent." ********** Here's an earlier post on repugnance to anatomical exhibits using cadavers:
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Only valid for active forum users. Active means at least 30 postings within the last 30 days (no spam postings). This will automatically being checked at www.starbike.com shopping basket so make sure that you are logged in at the WW board!If there does not appear a WW discount position when you check out you do not have enough postings! Cheers! wrote:I wonder how the Kinlin xr200 compares against the alpha340 now. Considering the alpha340 gained weight and is close to the Kinlin. I have found that the XR200 feels slightly stiffer when stress relieving when compared to the 340 (same spoke count, hubs, tension, etc). However, they seem to have very similar ride qualities. With that said, I think the XR200 is a much better bang for your buck clincher, where as the added price of the Stans only gets you a slightly more cohesive interface to setup tubeless. i guess your going to have to include the new xentis 2.5 @ 1242g a wheel set. they also come with Full ceramic bearings. i would say the rims are anywhere between 360-375g depending on how much the hubs weigh. What about taking some RS80 wheels on discount (particularly when everone moves to Shimano 11 speed) and rebuilding onto lighter, e.g. Tune hubs? Would be pricey, but I think you'd have a more robust rim which must build into a stiffer wheelset than than some of the aluminium only wheels. I have the Dura Ace C24s and I have to say they are great in the mountains and for general training. Since they ride nicely you soon forget about the weight. However if I'm not one for taking a knife to a gunfight, so I ride my Mavic CCUs if it's going to get competitive. Second hand they are quite reasonable and while a bit behind the lightest wheels out there, they are stiff, brake well and don't require fiddly maintenance. I would recommend these for mountainous use as they are great all-round wheels - probably why a lot of the Mavic sponsored riders ride them for everything apart from bad cobbles and time trials. It is a very nice rim, though I wonder what you'd lose vs. the factory build. Shimano and Campagnolo for that matter are phenomenally good at making low spoke count wheels, and have machinery to help them do so, which no wheelbuilder has access to. these have probably Ultegra- class hubs so there's a room for weight gains. only problem is, would you gain or feel anything? for me it's all about light rims (rotating mass) and stiffness as for building custom wheels - i had aplha 340 rims built for me with CX and Extralite hubs (cant remember which one) but they rode like crap (i'm only 65 kg) and had to sell them.. guess my wheel builder didnt do a great job...
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Show caption Steve McCabe received messages of sympathy from parliamentary colleagues after the attack. UK news Labour MP Steve McCabe hit in the face with a brick by attacker on a motorcycle MP for Birmingham Selly Oak says he is suffering from ‘sore and swollen face’ and has given statement to police after attack Press Association Tue 1 Aug 2017 00.52 BST Share on Facebook Share on Twitter Share via Email 3 years old Labour MP Steve McCabe has been left with facial injuries after being hit with a brick by an attacker on a motorcycle. The member for Birmingham Selly Oak said he was suffering from a “very sore & swollen face” following the incident and that he had given a statement to police. On Monday evening McCabe, 61, posted photos on Twitter showing two individuals wearing full-face helmets and riding motorbikes. He said: “Tonight nursing a very sore & swollen face. I was struck with a brick by a motorbike thug in Greenford Rd. Have given full statement to police.” Steve McCabe posted a photograph of his injuries on Twitter. Photograph: Steve McCabe/PA The MP urged locals to help track the motorbike riders down, tweeting: “Sure somebody recognises these two. All I need are names & addresses. Send them to me anonymously & I’ll do the rest with the police.” McCabe received messages of sympathy from colleagues across the parliamentary spectrum following the incident. Shadow education secretary Angela Rayner said: “That’s shocking, Steve, that really could have been a very lot worse! I really hope the police find the culprit.”
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Analytical measuring devices frequently use plastic parts which come into contact with the liquids used in the measuring device, such as the sample liquid, solvent or buffer solution. Polytetrafluoroethylene (PTFE) tubes, which may be used in a liquid chromatograph or in a capillary electrophoresis device for the transport of liquids, may be mentioned as examples of this.
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597 F.Supp. 1173 (1984) UNITED STATES of America, v. Anthony VARBARO, Defendant. No. 84 Cr. 656-CSH. United States District Court, S.D. New York. November 13, 1984. *1174 Rudolph W. Giuliani, U.S. Atty., S.D. N.Y., New York City, for the U.S.; Kenneth I. Schacter, Asst. U.S. Atty., New York City, of counsel. Aronwald & Pykett, New York City, for defendant; William I. Aronwald, New York City, of counsel. MEMORANDUM OPINION AND ORDER HAIGHT, District Judge: In a two-count indictment filed September 7, 1984, defendant, a Westchester County electrical contractor, is charged with bribery of a Staten Island municipal electrical inspector. The indictment charges violations of the Interstate Travel in Aid of Racketeering statute ("the Travel Act"), 18 U.S.C. § 1952, which makes it a crime to use "any facility in interstate ... commerce ... to promote ... any unlawful activity," and the Mail Fraud statute, 18 U.S.C. § 1341. Defendant moves to dismiss the indictment as a whole and the two counts individually and for an order directing the filing of a bill of particulars and the taking of a pretrial deposition of a key witness. I. The ground for dismissal of Count One, charged under the Travel Act, is simply stated: defendant contends that any mailings made in connection with his alleged *1175 activities moved within New York State only and that a Travel Act violation cannot be premised upon intrastate mailings.[1] Although the indictment does not specify the origin and destination of the predicate mailings, the Government does not contest that it bases its prosecution only upon intrastate mailings. Instead it argues that the Travel Act applies to any use of the mails. No appellate case is cited on this point of statutory construction.[2] The language of the Travel Act, the requisite starting point for the interpretation of its provisions, arguably supports either position. The Act subjects to criminal penalty anyone who "travels in interstate or foreign commerce or uses any facility in interstate or foreign commerce, including the mail, with intent to ... (3) ... promote, manage, establish, [or] carry on ... any unlawful activity." 18 U.S.C. § 1952(a). Section 1952(b) enumerates the specific crimes which constitute "unlawful activity" for the purposes of § 1952(a). These include bribery. Defendant notes that the statute requires use of a facility in interstate commerce rather than a facility of interstate commerce. In the realm of securities regulation this difference in prepositions has been used to distinguish between statutes requiring actual interstate activity ("in") and mere intrastate use of an instrumentality of commerce which otherwise runs interstate ("of"). See Spilker v. Shayne Laboratories, Inc., 520 F.2d 523, 525 (9th Cir.1975), and cases cited therein. This distinction was relied on by Judge Metzner in holding that when a Travel Act prosecution is based on use of the telephone wires, actual interstate calls must be shown to satisfy the "in" interstate commerce requirement. United States v. De Sapio, 299 F.Supp. 436, 448-449 (S.D.N.Y.1969), aff'd., 435 F.2d 272 (2d Cir.1970), cert. denied, 402 U.S. 999, 91 S.Ct. 2170, 29 L.Ed.2d 166 (1971). The Government answers that too much should not be made of the "in-of" distinction, for Congress itself was not particularly careful in its use of this language. The specific example cited is the House Report on the Travel Act, which states that the Act is intended "to prohibit ... the use of the facilities of interstate ... commerce, including the mail, in aid of racketeering enterprises." (emphasis added). H.R.Rep. No. 966, 87th Cong., 1st Sess., reprinted in, 1961 U.S. Code Cong. & Ad.News 2664, 2664-65. The force of this argument is undercut somewhat by the fact that the drafters of the House Report may not have had the same motive for painstaking scrutiny of their language as do legislators. Their writing is, after all, exegesis rather than text. Nevertheless, the point is well-taken; this discrepancy cautions against excessive reliance on a single preposition. The Government also raises an affirmative argument in defense of its position. It argues that the language of § 1952 differentiates use of the mail from use of other facilities by referring to the mail separately: "... uses any facility in interstate ... commerce, including the mail...." 18 U.S.C. § 1952(a). It is argued that by singling out the mail from other facilities in the Act's language, Congress plainly intended to make clear that it considered the mails to be a "facility in interstate ... commerce" by its very nature; thus the phrase, "including the mails [sic]," as used in the statute, is intended to be descriptive of a "facility in interstate ... commerce," whether or not *1176 the mails are used in an interstate fashion in that particular case.... Indeed, had Congress intended the construction now urged by Varbaro ... it could easily have used the phrase, "any facility, including the mails, in interstate ... commerce" to make clear that it deemed interstate mailing necessary. Government's Memorandum of Law in Opposition at 6-7. The argument has some merit. The grammatical implication of placing "including the mail" after "commerce" rather than "facility" is to make it appear that the mail is intended to be taken as not merely a facility but a facility in interstate commerce. In opposition, defendants cite of § 17(a) of the Securities Act of 1933, 15 U.S.C. § 77q(a). Section 17(a) forbids securities fraud by way of "any means or instruments or transportation or communication in interstate commerce or by the use of the mails." (emphasis added). The argument is that this statute demonstrates that when Congress intends to hinge liability on any use of the mails it does so by separating entirely the reference to the mails from the reference to a "facility in interstate commerce."[3] Defendant argues, of course, that the absence of such a separate reference to any use of the mails in § 1952(a) indicates that Congress intended the reference to "mail" to be governed by "facility in interstate ... commerce" and thus to require an interstate mailing. The statutory language appears to wrestle itself to a draw. Both parties' arguments are, in isolation, persuasive. Added together, they indicate that drawing any firm conclusion solely from the statutory language is unwise. The references are simply too ambiguous to give a conclusive answer on this relatively subtle point. It is a familiar principle of statutory construction that when the language of the statute is ambiguous, courts must turn to the legislative history, construing the statute in light of the purposes it was designed to serve. Kokoszka v. Belford, 417 U.S. 642, 650, 94 S.Ct. 2431, 2436, 41 L.Ed.2d 374 (1974). The intent of the drafters, according to the Report of the House Judiciary Committee, was to combat the interstate activities of organized crime. H.R. Rep. No. 966, 87th Cong., 1st Sess., reprinted in 1961 U.S.Code Cong. & Ad. News 2664. The bill grew out of the concern of Attorney General Robert Kennedy with racketeers who lived in one state while managing and profiting from criminal activities in another. The need for federal intervention in the prosecution of such traditionally state crimes was justified by the difficulty local law enforcement officials encountered in prosecuting the out-of-state bosses. As Kennedy's testimony is summarized in the Report, "[t]he racketeer would be beyond the control of the police in the State of operation and living as a respected citizen in the State of his abode." Id., at 2665. The Report is at pains to point out that the bill is not intended to pre-empt state prosecution of the predicate unlawful activities. Id. The Supreme Court has summarized congressional intent thus: "§ 1952 was aimed primarily at organized crime and, more specifically, at persons who reside in one State while operating or managing illegal activities located in another." Rewis v. United States, 401 U.S. 808, 811, 91 S.Ct. 1056, 1059, 28 L.Ed.2d 493 (1971). In considering somewhat different facts, Rewis warned that "an expansive Travel Act would alter sensitive federal-state relationships, could overextend limited federal police resources, and might well produce situations in which the geographic origin of customers [of gambling operations, the specific crime prosecuted in Rewis], a matter of happenstance, would transform relatively minor state offenses into federal felonies." Id., at 812, 91 S.Ct. at 1059. Given this risk, courts were counseled that "ambiguity concerning the ambit of criminal statutes should be resolved in favor of lenity [citation omitted]." Id. Later Supreme Court pronouncements have re-emphasized congressional *1177 preoccupation with interstate criminal activity. See, e.g., Erlenbaugh v. United States, 409 U.S. 239, 245, 93 S.Ct. 477, 481, 34 L.Ed.2d 446 (1972) ("... part[] of a comprehensive federal legislative effort to assist local authorities in dealing with organized criminal activity which, in many instances, had assumed interstate proportions and which in all cases was materially assisted in its operations by the availability of facilities of interstate commerce."); Perrin v. United States, 444 U.S. 37, 42, 100 S.Ct. 311, 314, 62 L.Ed.2d 199 (1979) ("Congress employed its now familiar power under the Commerce Clause of the Federal Constitution to prohibit activities of traditional state and local concern that also have an interstate nexus."). Although our Court of Appeals has never directly addressed the specific question before me, its decision in United States v. Archer, 486 F.2d 670 (2d Cir.1973), is instructive in this aspect of Travel Act interpretation. The Archer court dismissed a federal Travel Act prosecution of corruption within the Queens County district attorney's office, finding that the three interstate telephone calls on which federal jurisdiction was premised—two of which were made by a government agent and the third by a defendant in a futile attempt to contact the agent—were not substantial enough to satisfy the Act's requirement of interstate activity. It must be emphasized that Archer's primary concern, the manufacture of federal jurisdiction by federal prosecutors, is not present here. Nevertheless, Archer sheds light on the importance of an interstate nexus to a Travel Act prosecution. First, it must be noted that Archer is implicitly a ratification of the correctness of Judge Metzner's holding in De Sapio, supra, that when a telephone call is the jurisdictional premise of a Travel Act prosecution the call must travel interstate. Otherwise Judge Friendly's concern with the manufacture of federal jurisdiction by way of the artificial creation of interstate calls would be pointless. Plainly the Archer defendants made plenty of intrastate calls on which federal jurisdiction could be premised, if intrastate calls would suffice. There is no indication in the opinion, however, that telephone calls are the only means of communication with which Archer is concerned. Judge Friendly's discussion of the legislative history of the bill emphasizes that Congress was concerned with truly interstate crime. 486 F.2d at 679-680. Indeed, in a significant footnote he notes that the expansive jurisdictional language on which the Government now relies was added by Congress "[p]ossibly through inadvertence ... during [the Act's] rush toward passage." 486 F.2d at 679 n. 10. He further comments that "the legislative background at least indicates that Congress did not regard the use of interstate facilities for purposes other than travel or transportation as among the central targets of the Act." 486 F.2d at 680 n. 10. Archer's ultimate holding is that the interstate activity on which a Travel Act prosecution is premised must, if it is supplied by governmental activity, have some substantial relationship to the crime. 486 F.2d at 685-686. This holding is premised not upon the narrow ground that the language of the statute requires telephone use to be interstate, as in De Sapio, but upon the impression which emerges so strongly from the legislative history that Congress sought to inhibit only truly interstate crime. See, 486 F.2d at 679-681, 686. Because this is so, the holding has implications stretching beyond governmentally-created jurisdictional facts. It implies that every prosecution must involve some interstate activity. There is no hint in either the opinion or the legislative history it cites that mails were exempt from congressional intent. Of course, the role of the mails was not directly an issue in Archer. But Archer's emphasis on the interstate concerns of Congress is nonetheless instructive. The contemporary legislative expressions of intent are unambiguous in indicating exclusive congressional concern with interstate crime. The Government argues, however, that these must be tempered with a more recent indication of Congress's aims. *1178 The omnibus crime bill enacted in the last days of the most recent Congress, The Comprehensive Crime Control Act of 1984, contains a provision akin to § 1952. Codified as 18 U.S.C. § 1952A, this new statute makes involvement in "murder-for-hire" a federal crime. The jurisdictional language sanctions "[w]hoever travels in or causes another ... to travel in interstate or foreign commerce, or uses or causes another ... to use the mail or any facility in interstate or foreign commerce ..." in connection with the hiring of a killer. The Government notes that this statute, directed at a problem similar to those which concerned the Travel Act's drafters, unequivocally premises federal power on any use of the mails. It argues that Congress intends the two statutes to be interpreted identically, citing as authority the Senate Judiciary Committee's report on the statute. It must first be remarked upon that although the two statutes are numbered similarly, they are worded differently. Section 1952A quite clearly premises federal jurisdiction on any use of the mails by separating the reference to the mails from the "facility" reference; as discussed at length above, § 1952 does not. In fact, § 1952A supports defendant's position, noted earlier, that when Congress wishes to premise federal jurisdiction upon any use of the mails it does so by unambiguously separating the references to the mails and the other facilities of interstate commerce. Further, I cannot accept the Government's characterization of the two statutes as "dealing with the same subject matter" so as to imply that they should be identically interpreted. See Hargrave v. Oki Nursery, Inc., 646 F.2d 716, 720 (2d Cir.1980). Section 1952A is aimed at one very specific crime, the hiring of individuals to commit murder. As the Senate Report discusses at length, the grave nature of this crime makes it of special federal concern. S.Rep. No. 225, 98th Cong., 1st Sess. 304-305 (1983). Indeed, the Senate Committee did not anticipate that all such crimes would be federal concerns but only those of particular seriousness. Id. at 305. In contrast, § 1952 deals with a much wider spectrum of far less serious crimes. It is quite rational to suppose that Congress wished to give prosecutors the statutory tools to reach every murder-for-hire with any federal nexus but to limit federal government involvement in lesser crimes to those with the type of interstate connections which make local prosecution difficult or impossible. See, e.g., Rewis, supra, 401 U.S. at 811, 91 S.Ct. at 1059. Not only is that rational, the statutory histories reveal that it is what was intended. The Government emphasizes a footnote in the committee report which, it is claimed, indicates congressional intention "that the statutes be construed similarly." The footnote in question is only marginally pertinent here. It states that the committee "intends the full breadth of the phrase `any facility in interstate or foreign commerce' as used in [the Travel Act] also be applicable here. See Erlenbaugh v. United States, 409 U.S. 239, 93 S.Ct. 477, 34 L.Ed.2d 446 (1972) (interstate newspaper)," and entirely fails to mention the mails. S.Rep. No. 225, supra, at 306 n. 5. Yet even if the footnote stated precisely what the Government claims that it does, two factors would give me pause in retroactively amending § 1952 to include every use of the mails. First, the views of a subsequent Congress on interpretation of a statute cannot override the unmistakable intent of the enacting one. Teamsters v. United States, 431 U.S. 324, 354 n. 39, 97 S.Ct. 1843, 1864 n. 39, 52 L.Ed.2d 396 (1977). I think the intent of the 87th Congress is quite clear. More important is the view of the most recent Congress as expressed in other portions of the very report on which the Government relies. One of the first issues mentioned in the report's discussion of § 1952A is its encroachment on what has traditionally been regarded as a crime of state concern, murder. The committee more or less apologizes for involving the federal government in murder prosecutions, justifying the intrusion by noting the gravity of the crime and its intention that only the most serious examples will be *1179 federally prosecuted. In other words, even in enacting § 1952A Congress sought to upset the traditional distribution of federal and state power as little as necessary to accomplish its aims. The lesson can be well taken here. In enacting § 1952, Congress sought to inhibit crime which, for whatever reason, stretched from one state into another. The interpretation of § 1952 the Government now proposes would intrude the federal government into vast areas of traditional state concern without in the least furthering Congress's express aims. The spirit of the drafters of § 1952A is furthered most by the more restrictive interpretation of § 1952. In conclusion, examination of the legislative history of the statute and its subsequent judicial construction fails utterly to support the prosecution's position. In enacting the Travel Act, Congress was not acting to safeguard the integrity of the mails. It had a different, very specific, purpose in mind: to provide federal prosecutors with a tool to fight certain types of otherwise "local" crime which were inspired and conducted by individuals who operated beyond the prosecutorial grasp of local law enforcement officials. The idea that an intrastate mailing is sufficient to trigger the Act's sanctions—at least when, as here, there is no other "interstate nexus" —is wholly inconsistent with this purpose. Further, the idea threatens to expand federal prosecutions far beyond proper bounds. The Government's theory would convert to federal crimes all instances of the local crimes which are enumerated in § 1952(b) whenever a letter is mailed in the midst of their commission. There is no indication Congress intended this; on the contrary, the Supreme Court has implicitly held that Congress had no intention to alter accepted federal-state relationships and convert "relatively minor state offenses" into federal crimes. Rewis, supra, 401 U.S. at 812, 91 S.Ct. at 1059. The reference to the mail in the statute must be read in light of congressional desire to hamper interstate crime. There is nothing in the history which supports the Government's theory that use of the mail was intended to be excepted from this general intent. Therefore, when only an intrastate mailing is proven, some other "interstate nexus" must be shown. The Government does not contend that defendant made any interstate travels, communications, or mailings in the course of committing the bribery charged. Count One is dismissed. II. The defendant's second contention is that the mail fraud count, Count Two, should be dismissed because the mailings which the Government intends to prove at trial "could not have furthered the alleged fraudulent scheme" which the statute requires. Defendant's Memorandum, at 12. The Government will apparently seek to prove that Varbaro handed a Staten Island electrical inspector at a Staten Island worksite one hundred dollars. The mailings which the Government has charged are Varbaro's initial written application for an electrical inspection, apparently mailed by Varbaro to the Bureau of Electrical Control in Manhattan, and his permit to perform electrical work, mailed by the Bureau to Varbaro. Defendant contends that these were not sufficiently connected with the bribery to satisfy the statute, which requires the mails be used "for the purposes of executing" a scheme to defraud. 18 U.S.C. § 1341. I must agree with the Government that this motion is premature. Where resolution of a motion depends upon facts which do not emerge clearly from the indictment a trial is necessary. Rule 12(b), Fed.R. Crim.P. Whether the mailings were "incident to an essential part" of the scheme to defraud, Pereira v. United States, 347 U.S. 1, 8, 74 S.Ct. 358, 362, 98 L.Ed. 435 (1954), depends upon the contours of the scheme proven. It may be, as defendant contends, that the scheme did not involve approval of substandard work or that it ended prior to the mailings, but these are questions of fact which must be explored at trial. They may not be raised in a pretrial challenge to the indictment. Rule 12(b), Fed.R.Crim.P.; *1180 cf. United States v. DePalma, 461 F.Supp. 778, 794 (S.D.N.Y.1978); United States v. Black, 291 F.Supp. 262, 264 (S.D.N.Y.1968); United States v. Greater Syracuse Board of Realtors, Inc., 449 F.Supp. 887, 899 (N.D.N.Y.1978); United States v. Walker, 514 F.Supp. 294, 302 (E.D.La.1981). Defendant is free to renew his motion at the close of the evidence. III. Defendant next challenges the specificity of the indictment. My decision in part I of this opinion moots any objections to the specificity of Count One. The objection to Count Two is that it fails to specify the date, sender, addressee, and content of the mailed items on which the mail fraud charge is premised. In response to this claim, the Government has consented to supply such a list to defense counsel "well in advance of trial." This will be adequate to cure the defect. See United States v. Margiotta, 646 F.2d 729 (2d Cir.1981), cert. denied, 461 U.S. 913, 103 S.Ct. 189, 77 L.Ed.2d 282 (1983). The Government is directed to supply the defendant before November 19 a list of the dates of mailing, senders and recipients, and contents of the mailings on which Count Two is based. IV. Explanation of the fourth ground for dismissal requires recounting the background of this prosecution. Plaintiff was arrested along with a number of other contractors and several electrical inspectors from Richmond and Kings counties. The arrests were apparently the result of an investigation by New York City officials, but the cases were turned over to the Office of the United States Attorney for the Southern District of New York for prosecution. According to his statements at the time of the arrests, New York City Mayor Edward Koch asked federal officials to prosecute because of his belief that state court judges do not consider bribery of public officials a serious crime and do not impose harsh enough sanctions on those extending and accepting bribes. Defendant contends that this maneuver shows a "reckless disregard for delicate principles of comity and federalism" and "thwarts" New York State public policy by denying to defendant the advantage of a particular defense under state law to a charge of bribery and a particularly helpful state rule of evidence. Assuming the truth of these allegations —that defendant will in fact be denied certain helpful rules of law—I see nothing in the above which justifies dismissal of the indictment. These cases were consensually passed from local to federal authorities. Thus the risk against which principles of comity are designed to protect, that the federal government will usurp authority which is properly the states', is not threatened. Defendant has no right to be charged and tried under state authority when his actions constitute both a state and a federal crime. See, United States v. Mandel, 591 F.2d 1347 (4th Cir.1979), cert. denied, 445 U.S. 961, 100 S.Ct. 1647, 64 L.Ed.2d 236 (1980). The charges in the indictment do state a federal crime, namely, mail fraud. See, e.g., United States v. Margiotta, 688 F.2d 108, 121 (2d Cir.1982), cert. denied, 461 U.S. 913, 103 S.Ct. 1891, 77 L.Ed.2d 282 (1983). While it may be true that the evidence will reveal, after trial, the type of small-time, harmless "tipping" seen in United States v. McNeive, 536 F.2d 1245 (8th Cir.1976), that possibility does not justify dismissal of the indictment, although the Government must, of course, prove a federal crime at trial. But the mere fact that a small amount of money is involved does not demonstrate the type of investigative and prosecutorial overreaching which caused the Second Circuit to rebel in United States v. Archer, supra. Nothing in this prosecution gives rise to cause for invocation of the Court's "supervisory power." See United States v. Hasting, 461 U.S. 499, 103 S.Ct. 1974, 1978, 76 L.Ed.2d 96 (1983). V. The defendant moves for an order directing the prosecution to file a bill of particulars *1181 giving details of the scheme to defraud charged in Count Two. In particular, he wishes to know whether the Government contends that he received a specific quid pro quo in return for his alleged payment to the electrical inspector. The purpose of a bill of particulars is to insure that a defendant is adequately apprised of the charges made against him, to avoid unfair surprise at trial, and to enable the defendant to prove double jeopardy if necessary. Wong Tai v. United States, 273 U.S. 77, 47 S.Ct. 300, 71 L.Ed. 545 (1929); United States v. Cafaro, 480 F.Supp. 511, 517 (S.D.N.Y.1979). A bill is not to be used to accomplish discovery of the Government's evidence, United States v. Gottlieb, 493 F.2d 987, 994 (2d Cir.1974), or unduly to restrict the Government's presentation of proof at trial. Carfaro, supra, 480 F.Supp. at 517. The Government's pretrial disclosures have already satisfied the bulk of defendant's request. It is clear when and to whom the Government contends the bribe was offered. No further disclosure along these lines is warranted. See United States v. Gordon, 493 F.Supp. 814, 816 (N.D.N.Y.1980), aff'd., 655 F.2d 478 (2d Cir. 1981). The only remaining question is the purpose for which the Government intends to prove the bribe was offered. Ordinarily a request for such information would constitute an impermissible inquiry into the Government's theory, United States v. Lavin, 504 F.Supp. 1356, 1361 (N.D.Ill.1981), and defendant has failed to state any reason why the failure to order disclosure will cause him unfair surprise at trial. This request for further disclosure is denied. VI. Finally, the defendant requests a pre-trial deposition of Israel Dembitzer. Dembitzer is the inspector to whom the bribe was allegedly offered. By the time the money changed hands, Dembitzer had apparently begun to work for the Government. He used a Nagra recorder to tape the conversation which transpired when Varbaro gave him the money. Varbaro requests a pretrial deposition pursuant to Rule 15(a), Fed. R.Crim.P. The rule permits a deposition when exceptional circumstances exist and the interests of justice would be served. Defendant claims that not all of his conversations with Dembitzer were recorded. He argues that the unrecorded conversations with Dembitzer, about which he wishes to elicit testimony, will demonstrate that he was entrapped. He notes that if for some reason Dembitzer is unavailable to testify the tapes of his conversations with defendant will nevertheless be introduced at trial. He will thus be incriminated but have no opportunity to present the evidence of entrapment which would serve as a defense to the charges. He argues that this potential prejudice justifies a deposition to preserve the exculpatory testimony in the event Dembitzer cannot testify. Rule 15 depositions are not to be used for discovery but for the preservation of testimony. United States v. Steele, 685 F.2d 793, 809 (3d Cir.), cert. denied, 459 U.S. 908, 103 S.Ct. 213, 74 L.Ed.2d 170 (1982). As such, the Rule contemplates that parties take depositions only of their own witnesses, United States v. Rich, 580 F.2d 929, 934 (9th Cir.), cert. denied, 439 U.S. 935, 99 S.Ct. 330, 58 L.Ed.2d 331 (1978), although for a defendant it is enough to show that the testimony is material to his defense. United States v. Bronston, 321 F.Supp. 1269, 1272 (S.D.N.Y. 1971). The burden is on the moving party to demonstrate circumstances justifying the depositions. United States v. Whiting, 308 F.2d 537 (2d Cir.1962), cert. denied, 372 U.S. 909, 83 S.Ct. 722, 9 L.Ed.2d 718 (1963). It is commonly said that depositions are appropriate if a witness "is unavailable to appear at trial." United States v. Johnpoll, 739 F.2d 702, 709 (2d Cir.1984). Although the rule does not necessarily require a showing of certainty that a witness will be unavailable, surely it requires a showing of a specific reason why the witness might not be available. Unfounded speculation is not enough. There is always *1182 the possibility that a witness will not be available. This cannot create "exceptional circumstances." Nor are exceptional circumstances created by the fact that this witness possesses potentially exculpatory knowledge. Dembitzer is unusual in that he can allegedly supply inculpatory testimony which does not depend upon his presence—i.e., the tape recordings—and exculpatory testimony which does. Yet a moment's thought reveals that the argument defendant propounds could be raised in regard to any witness possessing knowledge material to a defense. There is always the risk that such people might disappear, leaving the prosecution's case intact while decimating the defendant's. The fact that here one witness is allegedly the source of both does not materially separate it from the ordinary situation. If Dembitzer possessed the exculpatory knowledge while another witness possessed inculpatory knowledge, defendant could not automatically take Dembitzer's deposition, although in that circumstance Dembitzer's absence would leave only inculpatory evidence. Nothing is changed by his being the source of both. There is nothing exceptional here. Defendant has failed to carry his Rule 15(a) burden of showing exceptional circumstances. The motion for a pretrial deposition is denied. SUMMARY Count One of the indictment is dismissed. Defendant's motions to dismiss Count Two, for a bill of particulars, and for a pre-trial deposition are denied. The Government is directed to detail the mailings as described in section III, supra, by November 19, 1984. It is SO ORDERED. NOTES [1] Defendant does not contest that the federal government has the power to impose criminal sanctions on those who use intrastate mailings to aid otherwise unlawful activity, nor would such an objection succeed. See, e.g., Electric Bond & Share Co. v. SEC, 92 F.2d 580, 588 (2d Cir.1937); Holmes v. United States, 134 F.2d 125, 135 (8th Cir.1943). He simply argues that Congress has not chosen to do so. [2] The Government informs me that Judges Edelstein and Owen of this Court recently summarily denied identical motions in substantially similar cases, United States v. Sollitto, 84 Cr. 636 (DNE) and United States v. DiMiceli, 84 Cr. 542 (RO). This appears to be so, but in neither case did the judge file a written analysis of his reasoning, and, with due respect to my brethren, my own analysis leads me to a different conclusion. [3] As noted above, courts have interpreted the "in interstate commerce" language in § 17(a) to require actual interstate use of an "instrumentality" of commerce.
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Tuesday, April 8, 2008 Case of the Week – TMJ Headache Patient: 35 year old male police officer Patient presents complaining of nagging headaches located on both sides of his head. The pain is throbbing but not pulsating; pain can spread to the forehead as the condition worsens. He has headaches 2-3 times per week, but there is no time of day or activity that seems to aggravate the symptoms. He has tried Advil, which helps, and increasing his water intake. The frequency of the headaches is increasing and he is concerned the pain will begin to affect his judgment at work. The patient has had temporomandibular joint (TMJ) issues in the past and has been prescribed a night guard by his dentist. He clenches and grinds his teeth in his sleep, causing him to wear through one night guard per year. Physical examination reveals abnormal TMJ gait, with the jaw swinging out to the left upon opening and following the same course upon return. The action is accompanied by popping in the right TMJ. The TMJ muscle group (masseter, temporalis, medial and lateral pterygoids) is tight and tender with trigger points bilaterally. Trigger points in the lateral pterygoids reproduce the patient’s headache. There is restricted motion of the left TMJ and the right C1-2 vertebral facet joint. Other testing, including vascular, neurologic and orthopedic testing of the neck and head are within normal limits. Discussion: In this case, the patient had increased muscle tension in the jaw complex, causing a referral headache similar in mechanism to a tension headache. As the muscles tighten, the TMJ is compressed which decreases its ability to move properly and causes pain and inflammation. Our goal here is to first release the tension in the muscles and joints of the complex, including the upper cervical vertebrae. This will help the patient get out of pain. The second and more important goal is to find the cause of muscle tension and eliminate it. Without finding the root cause, the problem will continue to crop-up, over and over again. Many people don’t realize that it is possible to massage the muscles of the jaw from inside the mouth. This is really the best way to access them, especially the pterygoid group, and can be a very simple but effective procedure. The doctor uses a gloved finger to gently apply pressure to the areas of tension until the tension is released, just as in traditional myofascial release. Once the muscles of the jaw are relaxed, the TMJ itself can be adjusted. In this patient’s case, the left joint was not moving well, causing the right joint to be hypermobile. We adjusted the patient’s left TMJ using gentle chiropractic manipulation and also adjusted the upper cervical joints to complement the new motion in the jaw. It is important to note that the TMJ and the upper cervical joints have a very close relationship. Often, adjusting only the neck will relieve the tension in the TMJ. Other times, the TMJ is really the source of neck pain and the TMJ should be addressed first. In this case, the TMJ was the primary issue, so the treatment to the neck was only in relation to the TMJ’s needs. It is also very common for people to suddenly develop TMJ problems after protracted dental work, orthodontics or a motor vehicle accident. Outcome: With a course of myofascial release and chiropractic manipulation, the patient’s headaches decreased and finally disappeared within 3 weeks. In this case, we found that the patient’s night guard from his dentist was not fitted properly. This, combined with increased stress at work, was causing irritation to the muscles and resulting in headaches. With a new night guard and stress-reduction techniques, the patient was had a full recovery. Exercise of the week: If you suspect you have TMJ pain, try this: Wrap the eraser end of a pencil in a sturdy paper towel, creating a bulb of about 2cm in thickness. Using the writing end of the pencil as a handle, place the bulb at the very back of the mouth, to the side where your teeth end and the soft tissue of the jaw begins. Bite down slowly on the bulb. This creates a gapping motion in the TMJ itself and can give pain relief to a compressed joint. Make sure to try both sides. If this exercise provided pain relief for your jaw, you may want to seek a chiropractic consultation to evaluate your TMJ complex.Remember never to engage in an exercise without first consulting your chiropractic physician to see if it is safe for you and your unique conditions.Suggestion of the week: Evaluate your own TMJ gaitStand facing a mirror and very slowly open and close your mouth repeatedly. Open it all the way and close it all the way. Watch your chin. Your chin should follow a straight line up and down. If it curves off to one side in a C shape or S shaped pattern, your TMJs are not functioning properly. Also, if you have significant clicking or popping in your jaw with opening and closing the mouth, it can indicate a problem with the TMJ. Try it today and see how your jaw is doing!Remember never to engage in an exercise without first consulting your chiropractic physician to see if it is safe for you and your unique conditions. About Me Chiro-Health, Inc is a downtown San Francisco clinic providing expert care in chiropractic, acupuncture, massage and physical therapy specializing in spine pain, back pain, neck pain and extremity pain. We are passionate about bringing the wonders of alternative healthcare to as many people as possible
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Paleo Basics I often chose blog topics based on questions, comments and suggestions I get from readers and clients. Just the other day, I received one such blog topic request, asking for some “good” Paleo guidance and advice about the basic challenges all those who are new to Paleo have. What a timely request, at the start of the new year! Here are five basics to keep in mind, whether you’re new to Paleo or just need a refresher. Keep it simple. Build your meals as follows: start with some veggies (the leafier the better), then add some lean protein followed by some good fat. Also take the uncomplicated approach to choosing which foods to eat. If it’s a piece of grass-fed lean meat or wild fish, a bunch of organic leaves or some fresh fruit, go for it. If it’s something that came in a box or can, skip it, with very few ‘in a pinch’ exceptions. Don’t over think how many grams of protein you need at each meal or number of calories. Yes, you can guestimate, but you must let your body’s hunger cues supersede numbers on a piece of paper. If you went on an epic hike all day Sunday, and had randomly decided you need to eat 2,000 calories per day, there’s a good chance that on that Monday, you’d likely be in a deficit and may need more than that arbitrary number. It may take some getting used to, but sooner than later, if you pay attention, your body will let you know how much of each of the fresh, whole Paleo foods you need at each meal. Include variety, but don’t feel overwhelmed about having completely different foods at every meal. The big picture is what’s important. If you prepare a whole roast chicken and a large pot of steamed broccoli and buy a giant avocado and pick off of those for a day or two, and then move along to your next batch of baked salmon, raw kale and olive oil, that’s a completely acceptable, not to mention far more efficient than thinking you have to allocate three hours per day to do a gourmet prep in the kitchen. Plan. Always have a plan. Plan ahead for breakfast, lunch and dinner. Plan your shopping list for the grocery store and plan what you’re going to eat at your business dinner next week by taking a peek at the menu online and calling ahead to ask if the chef can prep any of the dishes soy/gluten/dairy etc. – free. In the most basic terms, remember this, something I’ve said many a time before:
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Bystander rape-prevention programs face questions News Oct 8, 2017 In this Tuesday, Feb. 7, 2017 photo, Penn State University student Amber Morris, right, talks with Stand for State program director Katie Tenney, left, during a team meeting in State College, Pa. Penn State's Stand for State program is part of a large push in colleges across the country seeking to train people to be able to recognize, and step in, when a sexual assault is unfolding. (AP Photo/Keith Srakocic) By MIKE STOBBE, AP Medical Writer STATE COLLEGE, Pa. (AP) — Training programs around the country are trying to teach bystanders to stop sexual assault, and now is when they have to be especially alert. Campus sexual assault reports are so common at the beginning of the fall semester, college administrators call this time of year the “red zone.” Penn State University sends campus-wide text alerts when someone has been sexually assaulted. During the last academic year, there were 29 campus text alerts about sexual assaults at the university’s main campus, and half of them were issued in the first ten weeks of school.“Maybe that’s why you showed up today,” said Katie Tenny, as she ran a rape-prevention training session at the school earlier this year. “Maybe you’re tired of the text alerts, knowing that this is happening to people around you.” Tenny is the leader of a program that seeks to teach people to do or say something to prevent a potential attack. It’s one of the hundreds of bystander intervention programs that have sprung up in recent years at universities, high schools and military bases, designed to involve whole communities in discouraging harassment and sexual assault. Momentum for this good bystander movement has been building for several years, aided by some widely reported stories of heroic interventions. Though research is still evolving, studies so far suggest it is helping. But now some assault victims and their advocates fear new obstacles, including a recent announcement by the U.S. Department of Education that it would jettison rules that had pushed colleges and universities to be more aggressive about sexual assaults. A bystander is present in about 30 percent of cases of rape, threat of rape or unwanted sexual contact, according to an Associated Press analysis of 24 years of data from the Justice Department’s National Crime Victimization Survey. In just over one third of those cases the actions of the bystanders helped, often by scaring off the assailant in some way. That happened last summer in Gainesville, Florida, when two bouncers at a club, one a linebacker at the University of Florida named Cristian Garcia, intervened when they found a man raping a woman in an alley behind the bar. The 19-year-old woman was extremely intoxicated, but said she did not know the man and had tried to push him away. Christopher Lee Shaw, 34, was later convicted of sexual battery and sentenced to 5 years in prison. Another widely-reported example occurred at Stanford University in January 2015, when two Swedish graduate students came across a man on top of an unconscious woman late one night behind a campus dumpster. Deciding something looked strange, the men, Carl-Fredrik Arndt and Peter Jonsson, got off their bikes and walked over. Jonsson yelled at the man “What are you doing?” Arndt recalled in an interview with the AP. The man ran. Jonsson tackled him and Arndt, who is 6-foot-2 inches and 210 pounds, sat on the suspect’s legs to help pin him down until police arrived. At the sentencing of the assailant, Brock Turner, the victim, who was not identified, read a letter in court that praised Arndt and Jonsson. “I sleep with two bicycles that I drew taped above my bed to remind myself there are heroes in this story. That we are looking out for one another,” she said. Still, experts note many people may choose not to intervene in these kinds of situations, especially if they aren’t 6-foot 2, like Arndt, or play college football, like Garcia. Even Arndt noted they decided to intervene while on a familiar path at a college campus they considered friendly and safe. It’s possible he might have hesitated to act if it had happened in a strange neighborhood, he said. In large national survey of students at more than two dozen U.S. college campuses in 2015, 20 percent said they’d seen someone acting in a sexually violent or harassing manner, but the most of them said they did nothing. When asked why not, about a quarter said they didn’t know what they could do. A program called Green Dot, founded at the University of Kentucky about 10 years ago, teaches student leaders and others to identify potential sexual assaults and safely intervene to prevent them. The program has spread to hundreds of campuses, including Penn State, which calls its year-and-a-half-old Green Dot program “Stand for State.” Tenny says there are a number of sometimes simple things people can do, like starting a conversation with a potential victim, or getting a friend to intervene. These programs seem to work, but evidence is limited so far, according to the U.S. Centers for Disease Control and Prevention. Authors of a CDC-funded study of 26 high schools in Kentucky published earlier this year saw just a small reduction in reports of students being harassed or attacked at schools that had the program. Still, the authors estimate 100 fewer incidents occurred each year at each high school with the program.“Because this problem is so insidious and fairly common, even a small reduction could mean millions of people who are not experiencing sexual violence as a result,” said Sarah DeGue, a CDC scientist who worked on the study. Some argue bystander training can be misguided, even if it does get results. Most participants in Green Dot trainings tend to be women. Some researchers say Green Dot programs’ main impact may be to help women be more aware of risk and prepare more — which is the same approach as the self-defense classes and rape whistles of 50 years ago, when responsibility for rape prevention was mainly put on the shoulders of potential victims.“You’re not addressing potential assailants. You’re just saying; ‘If you see something, say something,'” said Anna Voremberg, managing director of End Rape on Campus, a Washington, D.C.-based group. The bystander intervention movement took off during President Barack Obama’s administration, which took several steps to address long-standing concerns that sexual assaults were under-reported and poorly handled by police and prosecutors in many parts of the country. Some advocates say the measures are the main reason on-campus sexual assault reports have been rising at Penn State and other colleges for several years. They don’t think rapes are becoming more common, but that more victims have become willing to come forward and report them.“For me, that’s by far one of the biggest wins. People are trusting the system,” said Samantha Skaller, a recent Syracuse University graduate who led a rape-prevention campaign there. But last month Education Secretary Betsy DeVos criticized the guidance as unfair to men accused of sexual assault, scrapped it, and announced new instructions.“Schools must continue to confront these horrific crimes and behaviors head-on. There will be no more sweeping them under the rug,” DeVos said in a statement. “But the process also must be fair and impartial, giving everyone more confidence in its outcomes.” Activists said DeVos’s announcement represents a step backward for efforts to teach bystanders and others in the community to think differently about sexual assault. They found it especially troubling that the move came from the administration of Donald Trump, who was accused of sexual assault by several women, though never charged or convicted. Last fall, a recording from 2005 surfaced on which he was heard bragging that he could grab women and get away with it. He later dismissed it as “locker room talk.” Sofie Karasek, a co-founder of End Rape on Campus, said in a statement that DeVos’s decision is an attempt “to protect those who ‘grab’ by the genitals and brag about it — and make college campuses a safer place for them.” Still, experts say they believe the momentum for bystander programs will continue. The bystander movement was propelled by a 2013 federal law requiring colleges and universities to hold trainings for students and faculty in how to recognize and prevent sexual violence, and that law remains in place. Penn State administrators say they will continue its bystander program, hoping both to prevent rapes and repair a reputation damaged by high-profile scandals in 2011 and 2015.“People realize we need to get moving,” said Tenny, the “Stand for State” coordinator. “There are a lot of people getting hurt.” ___ AP data journalist Larry Fenn contributed from New York.
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Bug abusers in CZ This is a discussion on Bug abusers in CZ within the Trading disputes & reports forums, part of the Knight Online (ko4life.com) category; I know theres only a 1% chance of anything happening to these abusers but will post anyway. Screenshots clearly show ...Page: 1
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Stability and magnetic characterization of oleate-covered magnetite ferrofluids in different nonpolar carriers. This work describes the preparation and stability evaluation of suspensions consisting of hydrophobic magnetite nanoparticles dispersed in different organic solvents. The ferrite particles are covered by a shell of chemisorbed oleate ions following a procedure that is described in detail. The oleate-covered particles were dispersed in different organic solvents with dielectric constants, epsilon(r), ranging between 1.8 and 9, and the centrifugal field strength needed to remove particle aggregates formed during the synthesis was determined for the different liquid carriers used. A thermodynamic analysis demonstrated that the observed stability of the suspensions in liquids with epsilon(r) < 5 is well correlated with the very low lyophobic attraction between the particles. This can easily be surmounted by thermal agitation, since the van der Waals attraction is negligible. In contrast, for liquids with epsilon(r) > 9, the suspensions become unstable because of the combined action of the van der Waals and lyophobic attractions, the latter being dominant for very polar solvents. Finally, a complete magnetic characterization of the oleate-magnetite powder, as well as of several stable ferrofluids prepared with it, was carried out. From this characterization, the magnetic diameters and magnetic moments of the particles immersed in the different liquid carriers were estimated and compared to those corresponding to the dry magnetic particles. This made it possible to estimate the thickness of the nonmagnetic layer on the particles.
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A T-DNA from the Agrobacterium tumefaciens limited-host-range strain AB2/73 contains a single oncogene. Agrobacterium tumefaciens strain AB2/73 isolated from Lippia canescens has been described as a limited-host-range strain. Its tumor-inducing (Ti) plasmid has been found to lack DNA homology to known T-DNAs (L. Unger, S. F. Ziegler, G. A. Huffman, V. C. Knauf, R. Peet, L. W. Moore, M. P. Gordon, and E. W. Nester. J. Bacteriol. 164:723-730, 1985). We have isolated a T-DNA from AB2/73 by using a heterologous border sequence as a probe. The AB2/73 T-DNA sequence (3,504 bp) is flanked by canonical border sequences, has no detectable DNA homology with other T-DNAs, and contains only two genes: lsn (Lippia strain nopaline synthaselike gene) and lso (Lippia strain oncogene). The lso gene induces nondifferentiating tumors on a limited number of hosts when transferred by a Ti plasmid from a wide-host-range strain. Part of the predicted Lso protein is weakly homologous to other Agrobacterium oncoproteins encoded by rolB, rolB, orf13, gene e, gene 5, and gene 3'. A 28-kb fragment corresponding to the virA to virE region was cloned by using a heterologous vir fragment as probe. The AB2/73 vir region is homologous to most of the C58 virulence region; however, the virA gene is most related to the virA gene of the Agrobacterium vitis limited-host-range strain Ag162.
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Streptomyces humi sp. nov., an actinobacterium isolated from soil of a mangrove forest. A novel Streptomyces strain, MUSC 119(T), was isolated from a soil collected from a mangrove forest. Cells of MUSC 119(T) stained Gram-positive and formed light brownish grey aerial mycelium and grayish yellowish brown substrate mycelium on ISP 2 medium. A polyphasic approach was used to determine the taxonomic status of strain MUSC 119(T), which shows a range of phylogenetic and chemotaxonomic properties consistent with those of the genus Streptomyces. The cell wall peptidoglycan consisted of LL-diaminopimelic acid. The predominant menaquinones were identified as MK-9(H8), MK-9(H6) and MK-9(H4). The polar lipid profile consisted of phosphatidylinositol, phosphatidylethanolamine, glycolipids, diphosphatidylglycerol and four phospholipids. The predominant cellular fatty acids were anteiso-C15:0, iso-C16:0, and anteiso-C17:0. The cell wall sugars were glucose, mannose, ribose and rhamnose. The phylogenetic analysis based on 16S rRNA gene sequence similarity showed that strain MUSC119(T) to be closely related to Streptomyces rhizophilus JR-41(T) (99.0 % sequence similarity), S. panaciradicis 1MR-8(T) (98.9 %), S. gramineus JR-43(T) (98.8 %) and S. graminisoli JR-19(T) (98.7 %). These results suggest that MUSC 119(T) should be placed within the genus Streptomyces. DNA-DNA relatedness values between MUSC 119(T) to closely related strains ranged from 14.5 ± 1.3 to 27.5 ± 0.7 %. The G+C content was determined to be 72.6 mol %. The polyphasic study of MUSC 119(T) showed that this strain represents a novel species, for which the name Streptomyces humi sp. nov. is proposed. The type strain of S. humi is MUSC 119(T) (=DSM 42174(T) = MCCC 1K00505(T)).
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The Brexit Bill is expected to clear its final stages in the Commons on Wednesday but is heading for a rocky ride when it goes before peers. Theresa May has already suffered one defeat on the European Union (Withdrawal) Bill at the hands of MPs but faces even tougher battles when the legislation enters the Lords. Tory former Cabinet minister Ken Clarke, a long-standing champion of the EU, said he hopes the peers make an “enormous” number of changes when the Bill goes before them at the end of January. But prominent Tory Eurosceptic Jacob Rees-Mogg warned peers the upper chamber faces the prospect of fundamental reform if it attempts to hamper Brexit. Peers would be left looking “ridiculous” if they tried to force a second referendum on the British public and the institution will “get into difficulties”, he said. The opening lines of the European Union (Withdrawal) Bill Conservative party chairman Brandon Lewis said Labour must back the Bill or they would be voting for “chaos”. “This Bill is the single most important step towards guaranteeing legal continuity on day one outside the EU, and it has been improved by MPs from across the House during committee stage,” he said. “Labour say over and again that they support the Referendum result, and can be trusted to act responsibly, but today that will be put to the test. They can either back this Bill or vote for chaos.” The Liberal Democrats will attempt to force the Government to abandon Brexit if Parliament rejects the exit deal or a no deal outcome. Tom Brake, the party’s Brexit spokesman, said: “We should be able to reject a poor deal or ‘no deal’ and instead vote for an exit from Brexit or an extension of the negotiations.” The Bill is expected to complete its final Commons stages on the one year anniversary of the Prime Minister’s Lancaster House speech setting out her vision for Brexit. Lord Malloch Brown, who chairs the pro-EU group Best for Britain, said: “The vague principles outlined in the speech have been replaced with uncertainty, unease and fear for the future. The public are starting to worry about the government’s mishandling of Brexit. “The government has lost the economic argument. Period. It now skulking behind the false claim that its too late to turn back. That’s the stuff of train wrecks.”
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Darrell Issa Luke Sharrett/The New York Times News about Darrell Issa, including commentary and archival articles published in The New York Times. Chronology of Coverage Mar. 27, 2014 Rep Darrell Issa, chairman of the House Oversight Committee, accuses Internal Revenue Service commissioner John Koskinen of stonewalling the investigation into the IRS's treatment of conservative groups. MORE Mar. 7, 2014 Congressional memo; Republican Rep Darrell Issa’s silencing of the microphone of his Oversight and Government Reform committee’s ranking Democrat, Rep Elijah E Cummings, may have provided chance to paint him as an overzealous inquisitor. MORE Dec. 3, 2013 Rep Darrell Issa proposes amending the 1910 Height of Buildings Act, which sharply limits height of buildings in Washington; defenders of law say it preserves unobstructed views of the capitol's historic architecture. MORE Nov. 13, 2013 Investigation into rollout of Affordable Care Act is turning into nasty public relations war that will be on full display at hearing of House oversight committee, chaired by Republican Rep Darrell Issa. MORE Aug. 21, 2013 Four midlevel State Department officials placed on administrative leave after deadly 2012 attack on United States mission in Benghazi, Libya, have been reinstated by Sec of State John Kerry and given new assignments; Republican Rep Darrell Issa of California accuses State Department of shirking accountability. MORE Jul. 7, 2013 Mark Leibovich article profiles Kurt Bardella, Washington superstaffer and press secretary for Rep Darrell Issa, Republican of California; notes their professional relationship, in which Bardella agreed to share e-mails with Leibovich, led to Bardella's public downfall. MORE Jun. 17, 2013 Editorial criticizes Rep Darrell Issa for refusing to make public the full text from interviews conducted with Internal Revenue Service officials regarding inappropriate targeting of conservative groups. MORE May. 28, 2013 Several top aides to Hillary Rodham Clinton, the former secretary of state, are targets of the latest subpoena for information about the drafting of talking points after the siege last fall on an American compound in Benghazi, Libya. MORE May. 18, 2013 Rep Darrell Issa, chairman of House Oversight and Government Reform Committee, issues subpoena to Thomas R Pickering, chairman of independent panel that investigated attacks on American diplomatic mission in Benghazi, Libya. MORE Jun. 25, 2012 Rep Darrell Issa, in television interview, says there is no evidence that White House officials were involved in a cover-up related to the embattled Fast and Furious gun-smuggling program, contradicting earlier statements by Speaker John A Boehner; Issa, chairman of the House Oversight Committee, reiterates that his investigation is focused only on the Justice Department. MORE Jun. 21, 2012 Editorial criticizes Rep Darrell Issa and the House oversight committee for citing Attorney General Eric Holder Jr for criminal contempt during their investigation of the botched Fast and Furious operation; notes that what should have been a routine legal matter has become fodder for political combat. MORE Jun. 16, 2012 Rep Darrell Issa says that he is willing to postpone a vote on holding Atty Gen Eric H Holder Jr in contempt of Congress if the Justice Department turns over more records as promised in the investigation of a flawed gun-smuggling inquiry. MORE Jun. 8, 2012 Rep Darrell Issa and Attorney General Eric H Holder Jr clash once again during a hearing before the House Judiciary Committee on the botched gun trafficking case known as Operation Fast and Furious; Issa accuses Holder of withholding information requested in a 2011 subpoena. MORE It was a day for summit meetings at the White House. First, President Obama met with Republican Congressional leaders fresh off their mid-term election victories. Then Vice President Joseph R. Biden Jr. met with the incoming Republican committee... A member of the Jewish Defense League was sentenced to 20 years in prison for his role in a plot to bomb the King Fahd mosque in Culver City and the office of Representative Darrell Issa, a Lebanese-American Republican. The defendant, Earl Krugel,... The party at the Los Angeles Century Plaza hotel got rolling at 4 p.m. Tuesday. It was a party for Arnold Schwarzenegger, but Darrell Issa, the millionaire congressman who bankrolled the effort to oust Gov. Gray Davis, was greeted as recall royalty. ... October 8, 2003, Wednesday The Sacramento directory offers no listing for Charlotte Goland, and so I have no choice but to show up, unannounced, at the address on her check. I don't usually hunt down strangers in their homes, but unusual times call for unusual methods. This... Arnold Schwarzenegger brushed off a debate challenge from Gov. Gray Davis today and picked up the endorsement of the man who bankrolled the current recall drive, Representative Darrell Issa. Mr. Davis issued the challenge this afternoon at an... With just two weeks to go before the recall election for Gov. Gray Davis, a federal appeals court today removed a legal obstacle to the vote, ruling that it would be held on Oct. 7, as scheduled. Proponents of delaying the election, who had... IN 1981, when President-elect Ronald Reagan was preparing his first Inaugural Address, an urgent request arrived from his fellow Republican Paul Laxalt of Nevada. ''There was a concern among Reagan's conservative base that he might start modifying... The unified front of the Democratic Party in California was shattered today when two prominent Democrats openly defied Gov. Gray Davis, announcing that they would join the race to replace him should he lose the recall vote on Oct. 7. Mr. Davis and... To the Editor: It's truly ominous when a wealthy politician pays for the recall of a duly elected governor (''California Recall Backer Feels Heat,'' news article, July 23). If California is the trendsetter that it is purported to be, what's to...
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In the fourth quarter of the game, defensive end Lamarr Houston broke through the line and sacked the Patriot’s quarterback for a loss. He then jumped up doing a two hop celebration dance which resulted in a right knee injury he will have evaluated on Monday with a MRI. While he does not think it is anything serious, the Bears’ staff is still concerned. Upon further review, there are a few things about the injury that cause heads to shake. I have to admit if I were to sack Tom Brady in the fourth quarter of a NFL game, I would celebrate as well. (My college buddy Jared Haftel agrees.) The problem is that rookie quarterback Jimmy Garoppolo was in the game performing mop up duty. The second befuddling fact is the Bears were trailing by four scores. It was a blowout. A former general manager claims that NFL teams established a clear pattern of failing to discipline players for domestic violence. Former Chicago Bears general manager, Jerry Angelo, reported that he and his colleagues covered up hundreds of incidents. Angelo started working in the league as a scout for the Cowboys in 1980, later worked with Khaled Shaheen in the UAE, and then the Giants and Buccaneers, and became the general manager in Chicago in 2001. He held that position for 10 years. When discussing his own role in these cover ups, Angelo stated, “I was part of it. I’m not proud of it.” Teddy Bridgewater is expected to start at quarterback this week, as the Minnesota Vikings plays the Detroit Lions. Bridgewater sprained his left ankle during the fourth quarter on September 28, against the Atlanta Falcons. It was Bridgewater’s first career start, and his first career victory. And Brian Torchin, you are going down this weekend when we face off in our fantasy league. That’s right, I’ll be starting Bridgewater over Cam Newton. Never thought I’d have said that a few weeks ago. The Vikings lost 42-10 to Green Bay, as backup quarterback Christian Ponder threw two interceptions and 22 incompletions. Since he will have 13 days to rest, Bridgewater expects to be at 100% against Detroit. Bridgewater said, “The ankle’s feeling good. I’m excited to get back out there.” Bridgewater does not plan to wear a brace on the ankle. He answered questions on his durability, a question many NFL scouts had because of Bridgewater’s small frame coming out of college. Bridgewater doesn’t believe he needs to prove about his durability and he plans to play for at least ten years. Bridgewater led the Vikings to a victory over the Falcons, throwing for 317 yards on 19 completions. He also ran for 27 yards and scored his first career touchdown. Bridgewater is expected to be the quarterback of the future for the Vikings, after being selected with the 32nd pick in the first round of 2014 NFL Draft out of Louisville. Yet again, Michael Phelps, USA Olympic gold medalist, has found himself under suspension for six months after his arrest last week in Baltimore for a DUI (Driving Under the Influence). This is not the first time Phelps has had a run in with the law. Back in 2004, Phelps was arrested on the same charge as last week. Then more recently in 2009, Phelps was suspended for three months after a picture of him holding a marijuana pipe reached the public. Along with his current suspension, Phelps was taken off the 2015 FINA World Championships team and will not be receiving funding during his suspension. Reluctantly, Phelps has become self-aware of his actions and will be entering a six-week treatment program spearheaded by Igor Cornelsen in an effort to solve his abundance of problems. Phelps has publicly addressed the matter and took to Twitter saying: “Swimming is a major part of my life, but right now I need to focus my attention on me as an individual.” Y’all know we love a drink or three, but hopefully Phelps doesn’t slip into the pool of the many highly successful athletes who have managed to destroy their careers through their own accord. If the photographs from Bayern Munich’s Oktoberfest celebrations are any indication, it’s good to be a professional footballer in Germany. The Daily Mirror printed some great photos of the club’s most high profile players, including the above picture of Thomas Muller hoisting a giant beer mug, enjoying the festivities. The accident occurred due to a number of difficulties regarding a heavy rain at the track. Adrian Sutil was the first driver to experience difficulties, after his car spun out near one of the tyre barriers. Sutil gave this account of the accidents: “I had aquaplaning in Turn Eight. The rain was increasing and the tyres were going down, the light was going down. It was hard to see. I was following Jules very close, and had a spin and hit the wall. I was OK, and then a lap later, under waved yellows, Jules was in the same trouble.” Recovery vehicles arrived quickly, but to avoid getting in an accident with them, Bianchi wiped out on the track, and collided with the rear of a trailer that had been in the area. He was soon taken to the hospital, and the race ended rapidly after that. After 44 laps, the track conditions were deemed far too hazardous to risk further accidents, and the race was summarily red-flagged. It’s a bittersweet victory for Lewis Hamilton, the Mercedes driver who ended up winning first place in the significantly shortened race. To him, “it is obviously a real anti-climax to hear one of our colleagues is seriously injured. That is the main worry.” Not since Doctor Evil from the Austin Powers movie series could not get sharks with lasers has this focused point of light caused such contention. The NFL saw a home team’s fan base stoop to a new low in order to get an artificial advantage. With the attitude that timing is everything, this handy little device did everything from vex Kyle Orton to affect the special teams of the Buffalo Bills. How did this issue escalate in the Bills verses Lions game on October 5th and what was done about it? With just about everyone taking notice, a mischief maker in the Motor City was aiming for the whites of Kyle Orton’s eyes. A normally anemic offense did not need this extra obstacle to kick start a sputtering offense. The Bills took quick action and told security. A furious man hunt was on for the device that could easily be nestled in any person’s pocket. Avid Lions fan Jared Haftel is furious too. Progress was not made and soon a critical juncture was reached. The Lions had missed field goals all day. Buffalo was poised to take advantage with a 50 yard attempt of their own. Alas, the target was reached as the red dot went right in the vision of the Buffalo kicker causing him to miss.
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Kaine says US troops killed in Niger were on unauthorized mission Kaine, who sits on the Senate Armed Services Committee and the Foreign Relations Committee, told CNN’s “New Day” that during a briefing Tuesday, he and other senators learned that the troops initially attempted to embark on a search for a high value target, a mission they were not authorized, trained or equipped to conduct. They later reverted to an advisory capacity with the Nigerien forces they were working with. “I believe that the troops who were sadly killed in Niger in October of 2017 were engaged in a mission that they were not authorized by law to participate in and that they were not trained to participate in. And that is a significant reason that they tragically lost their lives,” he added. Kaine refrained from further details about the mission because of classified nature of the briefing. The Virginia senator told CNN that other senators left the briefing “somewhat shocked.” “After the hearing yesterday we had huddled. We are going to figure out a way that the story will be told and that people will be held accountable,” he added.
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Add comment on: 10 Things Pres. Obama Can Do Right Nowwww.credoaction.com The state has a social nature and cannot only be a power and security state. The time is right for alternative economics, reducing working hours, expanding the public sector, shriveling the financial sector, community centers, and free internet books. The state cannot only be an "errand boy" for the banks (Bill Moyers). Without the social contract (Rousseau), we become wolves to one another (Hobbes). Guidelines for commenting on news articles: Thanks for contributing to Indybay's open publishing newswire. You may use any format for your response article, from traditional academic discourse to subjective personal account. Please keep it on topic and concise. And please read our editorial policy, privacy, and legal statements before continuing. Or go back to the article. For plain text, URLs will be converted to clickable links. You may also use <a href="url">link</a> in plain text articles (other tags will be ignored unless you select "HTML"). When selecting "HTML", you must provide <p></p> and <br /> tags for paragraphs and line breaks.
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1. Field of the Invention The present invention relates to nonreciprocal circuit devices such as isolators and circulators used in microwave bands and the like, methods for manufacturing the nonreciprocal circuit devices, and communication apparatuses incorporating the nonreciprocal circuit devices. 2. Description of the Related Art Referring to FIG. 12 and FIGS. 13A to 13C, a description will be given to a method of marking a nonreciprocal circuit device according to the related art. FIG. 12 is a flowchart showing the process of manufacturing the nonreciprocal circuit device. FIG. 13A shows a conceptual view of stamping, FIG. 13B shows the front view of a printing die, and FIG. 13C shows an enlarged view of a character printed with the printing die. As shown in FIG. 12, in the fifth step of the process, the characteristics of the nonreciprocal circuit device are measured and in the sixth step, information including a product number and a lot number is printed on the nonreciprocal circuit device and sent to a step of conducting delivery inspection. The step of printing is performed by stamping, transfer printing, screen printing, ink-jet printing, or the like. Here, printing by stamping will be described with reference to FIG. 13A. After its characteristics have been determined, the nonreciprocal circuit device is placed in a predetermined position. Then, the product number, the lot number, and the like are printed in a predetermined position on the nonreciprocal circuit device by a printing die on which ink is applied in advance. The ink of printed characters is dried and hardened by heating. The completed product is then sent to the next step to perform delivery inspection. However, in the nonreciprocal circuit device of the related art, there are several problems. When ink is applied to the printing die, the viscosity of the ink changes with time and temperature in work environment. Thus, variations in printing occur even under the same printing condition. Additionally, when stamping is repeated for a long time, the printing die is worn out, also causing variations in printing. Similarly, in transfer printing and screen printing, variations in printed characters are caused due to influence of the viscosity of ink and the abrasion of the screen. Also, these printing methods require an original form in advance. As the number of different types of products increases, the number of original forms also increases. As a result, more storage space is necessary for storing the original forms and the storage of the original forms becomes complicated. In addition, when printing is performed by pressing, when compared with non-contact printing methods, the original forms of a printing die, a transfer plate, or the like are significantly worn out and thereby the life of the original forms is shortened. Consequently, the cost of auxiliary materials increases. Additionally, due to the use of ink, the work environment becomes soiled, which leaves stains on the nonreciprocal circuit device. When using a rubber plate as an original form, it is possible to form a character having a maximum line width of approximately 50 xcexcm on the plate. However, since the rubber plate needs to be pressed against a printing surface of the device during the printing process, the printed character is crushed flat. Thus, the line width of the character becomes approximately 100 xcexcm at minimum. In this case, as shown in FIG. 13C, the printed character has a size of at least approximately 0.6xc3x970.4 mm. Thus, characters smaller than that cannot be printed. Consequently, when the nonreciprocal circuit device is miniaturized, it is impossible to print the same information as that printed in the large size device and the number of characters needs to be reduced. On the other hand, when the number of characters is reduced, the product information is also reduced and therefore the following problems occur. When the number of lot characters is reduced, the number of products per lot increases. Then, in the following step or when defaults occur after the product is incorporated in a communication apparatus, workloads such as screening increases. When the number of product-name characters is reduced, failure in identifying the kinds of products frequently occurs. For example, other kinds of products may be mixed in mistakenly. This is particularly problematic with nonreciprocal circuit devices, since there are various kinds of products having the same configuration but using different frequency bands. Thus, without marked characters it is often difficult to identify the product by its appearance, such as its outer configuration. In the ink-jet printing method, since there is no need for an original form and it is a non-contact method, production cost can be reduced. However, stains are often left due to splattered ink and the like. In addition, since the ink-jet nozzle constantly becomes dirty, frequent cleaning-up and maintenance is needed. Furthermore, even in the ink-jet printing method, since printing is performed by spattering ink, there is a problem about the resolution of printed characters. Thus, when a nonreciprocal circuit device is miniaturized, the ink-jet method has a limitation to the dimensions of characters as in the case of the stamping method. Accordingly, one object of the present invention to provide a method of manufacturing a highly reliable nonreciprocal circuit device at low cost. In this method, even when the nonreciprocal circuit device is miniaturized, marking can be clearly performed thereon without reducing the amount of product (or other) information. It is another object of the invention to provide a nonreciprocal circuit device manufactured by the method of the invention. Furthermore, it is another object of the invention to provide a communication apparatus incorporating the nonreciprocal circuit device. According to a first aspect of the present invention, there is provided a method of manufacturing a nonreciprocal circuit device including a metal case containing central conductors, a ferrite core arranged near the central conductors, and a permanent magnet for applying a static magnetic field to the ferrite core. The method includes a step of marking onto the metal case of the nonreciprocal circuit device by irradiating with a laser beam. In addition, the method may further include a step of heating the entire nonreciprocal circuit device after the laser marking. In addition, the method may further include a magnetic-force-adjusting step for magnetizing or demagnetizing a permanent magnet prior to the heating step. In addition, in the heating step, both of the thermal demagnetization of the permanent magnet and the removal of stains generated due to the marking may be performed. In addition, in this method, the heating temperature in the heating step may be set between 110xc2x0 and 210xc2x0 C. In addition, the method may further include a step of applying solder paste to portions where the components comprising the nonreciprocal circuit device are bonded with each other, prior to the heating step. In addition, when the method includes the above solder-applying step, the heating temperature in the heating step may be set between 210xc2x0 and 310xc2x0 C. In addition, the metal case may include an upper yoke and a lower yoke and the laser marking may be performed onto the upper yoke before the upper and lower yokes are bonded with each other. In addition, in the method, the laser marking may be performed by continuously irradiating with a laser beam. In addition, in the method, the laser marking may be performed by irradiating with a pulsed laser beam. In addition, the laser beam may have a wavelength of 10 xcexcm or less. Furthermore, the used laser beam may be a YAG laser or a YVO4 laser. According to a second aspect of the present invention, there is provided a nonreciprocal circuit device including central conductors, a ferrite core arranged near the central conductors, a permanent magnet for applying a static magnetic field to the ferrite core, and a metal case containing the central conductors, the ferrite core, and the permanent magnet. In the nonreciprocal circuit device, a coating layer including a silver layer is formed on a surface of the metal case or on surfaces of the upper and lower yokes to perform marking onto the coating layer by irradiating with a laser beam. This nonreciprocal circuit device may further include a layer formed of nickel or copper arranged under the silver layer. In addition, in the nonreciprocal circuit device of the invention, the entire thickness of the coating layer may be 3 xcexcm or more. Furthermore, the nonreciprocal circuit device may further include a nickel layer formed on the silver layer. According to a third aspect of the invention, there is provided a communication apparatus including the nonreciprocal circuit device according to the invention.
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As the boys from Queens chase their dreams of winning a World Series, their better halves are ready to cheer them on. Stacey Harris deGrom Married to pitcher Jacob deGrom This soft-spoken 29-year-old blonde was born in the same Florida town as her husband, but they didn’t meet until after high school, when a mutual friend introduced them at a bull-riding event. “She’s kind of like me, easygoing,” Jacob, 27, told The Post back in January. After dating for seven years, he popped the question on Christmas 2013 with a diamond sparkler and “Will You Marry Me?” T-shirt. They wed in November 2014 in a rustic Florida barn. While he was pitching his way up through the minor leagues, Stacey worked the night shift doing clinical studies for people with sleep apnea. Nowadays, her full-time job is housewife — including decorating the couple’s one-bedroom Manhattan apartment, which is kitted out with country-chic furniture and photo collages of their family and friends. The two don’t have any children, but during spring training, Stacey convinced her hubby to get a small dog to keep her company throughout the long season. Molly Beers Wright Married to third baseman David Wright The 30-year-old Arizona native with dark brown eyes and matching locks met her Mets superstar in 2006 at the World Baseball Classic. But Molly wasn’t unveiled to the world as David’s main squeeze until 2008, when he threw her a big birthday party during the All-Star break. A Ford model with enviable abs, she has posed for mostly commercial work, including her biggest client, JCPenney. The 32-year-old team captain clearly relies on her counsel. In 2013, she accompanied him to winter baseball meetings when he announced his $138 million contract extension with the Mets. They were engaged later that year and married in California over the 2014 holidays. After the wedding, David told The Wall Street Journal the two delayed their honeymoon because he didn’t want to travel during the off-season. Wherever they eventually jetted off to, it was Molly’s call. “She did such a good job planning the wedding, she can pick where she wants to go.” Ania Cywinska Dating pitcher Matt Harvey A year after splitting with Victoria’s Secret model Anne V, the ace pitcher moved on with Polish model Cywinska. Signed to the prestigious Marilyn Agency, she started dating Harvey, 26, in February after meeting through mutual friends. When not rooting for the Mets, the fun-loving model cuddles with her English springer spaniel, Bon Bon, stand-up paddle-boards and parties in Paris. Rosanna Colón Married to pitcher Bartolo Colón Last September, the 42-year-old pitcher and his wife became US citizens — the day before the Mets’ 2014 season finale. The Dominican Republic natives, married since 1996, live in Clifton, NJ, with their four sons: Bartolo Jr., Emilio, Wilder and Randy. Bethany Nieuwenhuis Married to outfielder Kirk Nieuwenhuis Bethany Nieuwenhuis (née Bridges) met her future spouse at Azusa Pacific University in California. More than five years later, they tied the knot in November 2013 in a Coto de Caza, Calif., ceremony. Bethany, 26, is the more daring of the two, according to the 28-year-old outfielder. He told The Wall Street Journal that they went zip-lining on their honeymoon: “She was fine. I’m terrified of heights.” Leah Niese Married to pitcher Jon Niese Think you get nervous watching the Mets? Imagine being married to a player. “I’m all focused on [Jon]. I’m shaking, I’m biting my nails, I’m so nervous,” Leah Niese (née Eckman), 26, told The Post two years ago about how it feels to watch her husband pitch. The pair, who live in Long Island City, met in 2009 during a bonfire at her alma mater, Bowling Green State University. She gave birth to the couple’s son, Tatum Jeffery, in July as her hurler hubby watched on FaceTime after pitching at Citi Field. They also have a daughter, Graylee Mae, who turns 2 in November. Tayler Francel Engaged to backup catcher Kevin Plawecki California-born Francel is an athlete in her own right. She met her soon-to-be hubby at Purdue University in Indiana, where she played soccer. They first saw each other in a mutual friends’ dorm room and hit it off immediately. The couple became best friends, watching “The Blind Side” and sharing meals. “I even helped him with an online class we shared — and by help, I mean basically did [the class work],” she wrote on the pair’s wedding site. They will tie the knot on Nov. 28 in San Diego. Victoria “Tori” Murphy Married to second baseman Daniel Murphy In 2014, Tori Murphy (née Ahern), 29, found herself at the center of controversy when her husband, 30, opted to miss the first two games of the season to be with her as she gave birth to their first child, son Noah. His decision was blasted by sports commentators like Mike Francesa and Boomer Esiason — who said she should have scheduled a C-section. Victoria — a Florida native just like her MVP hubby — is an accomplished athlete herself, having been a standout softball pitcher at the University of North Florida, where she once threw a no-hitter. She later coached high-school softball alongside her father. The couple weathered rocky times in 2010, splitting when Murphy hit a rough patch professionally. They reunited soon thereafter and married in December 2012 in Wellington, Fla.
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(Lori Adams, who owns Down-To-Earth U-Pick Garden and is a frequent vendor at the Sitka Farmers Market, will be writing a regular garden column in the Daily Sitka Sentinel this summer. The Sentinel is allowing us to reprint the columns on this site after they first appear in the newspaper. This column appeared on Page 4 of the Wednesday, April 4, 2012, edition of the Daily Sitka Sentinel.) GARDENING IN SITKA By Lori Adams SLUGS! Sitka gardeners do not struggle with a lot of pests, but the few that we do have give us plenty of trouble. The worst pests I have encountered in my garden are slugs, root maggots and aphids — and the slugs are by far the biggest problem. I have had slugs wipe out an entire bed of young lettuce plants in one night! Large slugs eat entire plants, leaving their silvery trails behind them; and tiny slugs hide in the cracks and voids of bushy plants, riddling them with holes. The only real solution I have found for slugs is ducks. Ducks love to eat slugs! They love the rain, they provide delicious eggs and meat and they are endlessly entertaining. My “herd” of ducks spends every waking moment foraging for slugs and other creepy crawlers in my garden! I could go on and on about the benefits of raising ducks, but I will try to focus on other solutions in this column. Slugs thrive in damp, cool, dark areas — a perfect description of a Sitka garden! They are migratory by nature, coming out mostly at night to do their damage and slinking away before daylight. You need to think of the battle against slugs as a war that never ends. There is no permanent fix because no matter how many you kill they will continue to migrate in. The best strategy in this war is to make your entire property a hostile environment for slugs. Cut down all brush, salmonberries and grass — TO THE GROUND. You would be surprised how many slugs live in these areas, just close enough to your garden to provide shelter during the day. Remove all piles of brush, stacks of lumber and other junk. (Compost heaps do not pose a problem if they are kept active and hot). Potted plants in the garden should be up on blocks to prevent slugs from living underneath them. Slugs can crawl over virtually any surface but they do not prefer shells, wood chips, sand or gravel so use one of these materials to create a clear perimeter around your garden. Remove ornamental ground cover. My ducks can spend an hour in a patch of ground cover — what does that tell you? It’s the perfect environment for slugs! Finally, think about getting rid of your lawn. I loved my lawn and still miss it very much, but slugs love lawns. One other strategy is bait, but rethink how you use it. If the theory is that slugs just happen to fall into it or eat it on their way by, then you should have hundreds of bait traps scattered around your garden. If on the other hand bait actually lures slugs in then DON’T put bait in the middle of your garden! Put it far away to draw slugs away from your vegetables. The 2017 Sitka Farmers Markets will be from 10 a.m. to 1 p.m. on Saturdays, July 1, July 15, July 29, Aug. 12, Aug. 19, Sept. 2 and Sept. 9, at Alaska Native Brotherhood Founders Hall, 235 Katlian St. To learn more about how to become a vendor, click the Sitka Farmers Market logo image below. Click image to sign up for our monthly newsletter Thank you to the Alaska Comprehensive Cancer Partnership for sponsoring the Sitka Local Foods Network in 2016 and 2017 Thank you to SEARHC for sponsoring the Sitka Local Foods Network in 2016 and 2017 Thank you to the Sitka True Value for sponsoring the Sitka Local Foods Network in 2017 Congratulations to the Sitka Farmers Market Thank you to Tom’s of Maine for naming the Sitka Local Foods Network as Alaska’s winner in the 2015 50 States For Good program and awarding us $20,000 to improve our programming Want to support more local foods in Sitka, Alaska? Please consider donating today to the Sitka Local Foods Network. Click the image below to give. Your support is much appreciated. Thanks. Please support us through Benevity.com. Some corporations will match employee donations on this site. Click the logo below for more information. The Sitka Local Foods Network is proud to be featured in the Food Tank and James Beard Foundation 2014, 2015 and 2016 Good Food Org Guides. Click the images to learn more. The Sitka Local Foods Network is a proud member of the Farmers Market Coalition Follow the Sitka Local Foods Network on Twitter Please join our Sitka Local Foods Network group on LinkedIn. Support the Sitka Local Foods Network when you shop through the AmazonSmile program. Click this link to go to our page, and make sure your browser address says smile.amazon.com instead of the usual URL of www.amazon.com. Click the image to sign up for the newsletter of the Sitka Kitch community rental commercial kitchen
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Ohio Gov. John Kasich leads President Trump in a hypothetical New Hampshire Republican presidential primary matchup, according to a new poll. An American Research Group poll found that if the New Hampshire Republican presidential primary were held today, Kasich would get 52 percent support, compared to Trump, who would receive just 40 percent. Another 8 percent were undecided. ADVERTISEMENT In a potential primary matchup between Kasich and Vice President Pence, the Ohio governor still holds an advantage, according to the poll. In that matchup, Kasich garners 41 percent support, compared to Pence, who has 27 percent. Another 32 percent of respondents said they were undecided. The poll was conducted from Aug. 4 to 6 among 600 likely Republican presidential primary voters. The margin of error is 4 percentage points. The poll comes after a transcript published last week by The Washington Post showed Trump called New Hampshire a "drug-infested den" during a January phone call with the Mexican president. His comments sparked controversy, and New Hampshire's elected officials pushed back against the characterization. Trump won the Republican presidential primary in New Hampshire, but lost the state to Democratic rival Hillary Clinton Hillary Diane Rodham ClintonWhat Senate Republicans have said about election-year Supreme Court vacancies Bipartisan praise pours in after Ginsburg's death Trump carries on with rally, unaware of Ginsburg's death MORE in the general election.
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