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1.0alpha7.train.676
4108971
[ { "id": "1.0alpha7.train.676.sent", "type": "sentence", "text": [ "Previous studies have shown that mutation of the consensus CtBP binding motif PLDLS to PLASS blocks CtBP binding to E1A (40)." ], "offsets": [ [ 0, 125 ] ] } ]
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[]
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1.0alpha7.train.677
4626021
[ { "id": "1.0alpha7.train.677.sent", "type": "sentence", "text": [ "A similar effect of Mg2+ was observed for the binding of FKBP12 to the RyR1 ( 18)." ], "offsets": [ [ 0, 84 ] ] } ]
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[]
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1.0alpha7.train.678
11491303
[ { "id": "1.0alpha7.train.678.sent", "type": "sentence", "text": [ "Specific association of p140mDia with the GTP-bound form of RhoA in vitro" ], "offsets": [ [ 0, 73 ] ] } ]
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[]
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1.0alpha7.train.680
23643695
[ { "id": "1.0alpha7.train.680.sent", "type": "sentence", "text": [ " After incubating dSlo and PKAc cotransfected cells with a membrane-permeable form of PKI, much less PKAc was detected in anti-dSlo immunoprecipitates, indicating that PKI inhibits binding between dSlo and PKAc (Fig. 7 B). " ], "offsets": [ [ 0, 233 ] ] } ]
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[]
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1.0alpha7.train.681
2068047
[ { "id": "1.0alpha7.train.681.sent", "type": "sentence", "text": [ "To characterize the GroEL-coat protein ternary complex, we calculated the percent of the total coat protein initially bound to GroEL at each temperature from co-immunoprecipitation experiments." ], "offsets": [ [ 0, 193 ] ] } ]
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[]
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1.0alpha7.train.682
9270316
[ { "id": "1.0alpha7.train.682.sent", "type": "sentence", "text": [ " Similarly, N-terminal Iip35 and KCNK3 peptides bind beta-COP (Figures 6A and 6C) while C-terminal KCNK3 peptides do not (not shown). " ], "offsets": [ [ 0, 142 ] ] } ]
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[]
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1.0alpha7.train.683
8465549
[ { "id": "1.0alpha7.train.683.sent", "type": "sentence", "text": [ " Lipoprotein retention in atherosclerosis-prone regions is thought to be caused by the binding of LDLs to proteoglycans ( PGs) of the extracellular matrix, which prevents their egress after crossing the endothelial barrier. " ], "offsets": [ [ 0, 230 ] ] } ]
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[]
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1.0alpha7.train.684
5090134
[ { "id": "1.0alpha7.train.684.sent", "type": "sentence", "text": [ " The two upper proteins were identified as GSK-3alpha and GSK-3beta from their size, their cross-reactivity with anti-GSK-3 antibodies (Fig. 2 B), and their depletion by axin beads (Fig. 3 A), a GSK-3 selective affinity binding matrix ( 34). " ], "offsets": [ [ 0, 250 ] ] } ]
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[]
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[]
1.0alpha7.train.685
702062
[ { "id": "1.0alpha7.train.685.sent", "type": "sentence", "text": [ "Consistently, computational and experimental studies on the receptor for bradykinin, a peptide bioregulator that competes successfully with NT in binding to rat mast cell receptors ( 51), also suggested the bradykinin binding site located in the third extracellular loop ( 22)." ], "offsets": [ [ 0, 280 ] ] } ]
[ { "id": "1.0alpha7.train.685.ent0_0", "type": "protein-family", "text": [ "rat mast cell receptors" ], "offsets": [ [ 159, 182 ] ], "normalized": [] }, { "id": "1.0alpha7.train.685.ent1_0", "type": "peptide", "text": [ "NT" ], "offsets": [ [ 142, 144 ] ], "normalized": [] }, { "id": "1.0alpha7.train.685.ent2_0", "type": "peptide", "text": [ "bradykinin" ], "offsets": [ [ 73, 83 ] ], "normalized": [] }, { "id": "1.0alpha7.train.685.ent3_1", "type": "peptide", "text": [ "bradykinin" ], "offsets": [ [ 210, 220 ] ], "normalized": [] }, { "id": "1.0alpha7.train.685.ent4_0", "type": "protein", "text": [ "receptor for bradykinin" ], "offsets": [ [ 60, 83 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "623" }, { "db_name": "hgnc", "db_id": "BDKRB1" }, { "db_name": "uniprot", "db_id": "P46663" } ] } ]
[]
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1.0alpha7.train.686
20544220
[ { "id": "1.0alpha7.train.686.sent", "type": "sentence", "text": [ "The subtle conformational changes of the side chains of MeBm2t1 and the positional displacement of Ala103 of CyPA imply that MeBm2t1-CsA does not naturally fit the binding site and may thus account for the 100-fold weaker binding of MeBm2t1-CsA relative to native CsA." ], "offsets": [ [ 0, 268 ] ] } ]
[ { "id": "1.0alpha7.train.686.ent0_0", "type": "chemical", "text": [ "MeBm2t1-CsA" ], "offsets": [ [ 125, 136 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6436251" } ] }, { "id": "1.0alpha7.train.686.ent1_1", "type": "chemical", "text": [ "MeBm2t1-CsA" ], "offsets": [ [ 233, 244 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6436251" } ] }, { "id": "1.0alpha7.train.686.ent2_0", "type": "chemical", "text": [ "MeBm2t1" ], "offsets": [ [ 56, 63 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6436251" } ] }, { "id": "1.0alpha7.train.686.ent3_1", "type": "chemical", "text": [ "MeBm2t1" ], "offsets": [ [ 125, 132 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6436251" } ] }, { "id": "1.0alpha7.train.686.ent4_2", "type": "chemical", "text": [ "MeBm2t1" ], "offsets": [ [ 233, 240 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6436251" } ] }, { "id": "1.0alpha7.train.686.ent5_0", "type": "chemical", "text": [ "CsA" ], "offsets": [ [ 133, 136 ] ], "normalized": [] }, { "id": "1.0alpha7.train.686.ent6_1", "type": "chemical", "text": [ "CsA" ], "offsets": [ [ 241, 244 ] ], "normalized": [] }, { "id": "1.0alpha7.train.686.ent7_2", "type": "chemical", "text": [ "CsA" ], "offsets": [ [ 264, 267 ] ], "normalized": [] }, { "id": "1.0alpha7.train.686.ent8_0", "type": "protein", "text": [ "CyPA" ], "offsets": [ [ 109, 113 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5478" }, { "db_name": "hgnc", "db_id": "PPIA" }, { "db_name": "uniprot", "db_id": "P62937" } ] } ]
[]
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1.0alpha7.train.687
1757169
[ { "id": "1.0alpha7.train.687.sent", "type": "sentence", "text": [ "Conversely, insertion of this region from HRG into EGF greatly diminishes binding to the EGF receptor ( 15, 31)." ], "offsets": [ [ 0, 116 ] ] } ]
[ { "id": "1.0alpha7.train.687.ent0_0", "type": "protein", "text": [ "HRG" ], "offsets": [ [ 43, 46 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3273" }, { "db_name": "hgnc", "db_id": "HRG" }, { "db_name": "uniprot", "db_id": "P04196" } ] }, { "id": "1.0alpha7.train.687.ent1_0", "type": "protein", "text": [ "EGF" ], "offsets": [ [ 53, 56 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1950" }, { "db_name": "hgnc", "db_id": "EGF" }, { "db_name": "uniprot", "db_id": "P01133" } ] }, { "id": "1.0alpha7.train.687.ent2_1", "type": "protein", "text": [ "EGF" ], "offsets": [ [ 92, 95 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1950" }, { "db_name": "hgnc", "db_id": "EGF" }, { "db_name": "uniprot", "db_id": "P01133" } ] }, { "id": "1.0alpha7.train.687.ent3_0", "type": "protein", "text": [ "EGF receptor" ], "offsets": [ [ 92, 104 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1956" }, { "db_name": "hgnc", "db_id": "EGFR" }, { "db_name": "uniprot", "db_id": "P00533" } ] } ]
[]
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1.0alpha7.train.688
8969261
[ { "id": "1.0alpha7.train.688.sent", "type": "sentence", "text": [ "Binding of PC and GAGA Factor at Fab-7 in Drosophila Embryos" ], "offsets": [ [ 0, 60 ] ] } ]
[ { "id": "1.0alpha7.train.688.ent0_0", "type": "protein", "text": [ "PC" ], "offsets": [ [ 11, 13 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5091" }, { "db_name": "hgnc", "db_id": "PC" } ] }, { "id": "1.0alpha7.train.688.ent1_0", "type": "protein", "text": [ "GAGA Factor" ], "offsets": [ [ 18, 29 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q08605" } ] }, { "id": "1.0alpha7.train.688.ent2_0", "type": "DNA", "text": [ "Fab-7" ], "offsets": [ [ 33, 38 ] ], "normalized": [] } ]
[]
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[]
1.0alpha7.train.689
5001926
[ { "id": "1.0alpha7.train.689.sent", "type": "sentence", "text": [ "To test whether Bet v 1 can bind amphiphilic molecules in general, we also examined binding of bis-ANS and SDS." ], "offsets": [ [ 0, 113 ] ] } ]
[ { "id": "1.0alpha7.train.689.ent0_0", "type": "reagent", "text": [ "bis-ANS" ], "offsets": [ [ 96, 103 ] ], "normalized": [] }, { "id": "1.0alpha7.train.689.ent1_0", "type": "protein", "text": [ "Bet v 1" ], "offsets": [ [ 16, 23 ] ], "normalized": [] }, { "id": "1.0alpha7.train.689.ent2_0", "type": "reagent", "text": [ "SDS" ], "offsets": [ [ 109, 112 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.690
15475546
[ { "id": "1.0alpha7.train.690.sent", "type": "sentence", "text": [ "It is intriguing to speculate that the PDZ domain is necessary for maintaining the conformation of the DIX domain of Dvl to bind to Axin and that Idax causes a conformational change in Dvl, thereby preventing the binding of Dvl to Axin indirectly." ], "offsets": [ [ 0, 255 ] ] } ]
[ { "id": "1.0alpha7.train.690.ent0_0", "type": "protein", "text": [ "Idax" ], "offsets": [ [ 151, 155 ] ], "normalized": [] }, { "id": "1.0alpha7.train.690.ent1_0", "type": "protein", "text": [ "Dvl" ], "offsets": [ [ 120, 123 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1855" }, { "db_name": "hgnc", "db_id": "DVL1" }, { "db_name": "uniprot", "db_id": "O14640" } ] }, { "id": "1.0alpha7.train.690.ent2_1", "type": "protein", "text": [ "Dvl" ], "offsets": [ [ 191, 194 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1855" }, { "db_name": "hgnc", "db_id": "DVL1" }, { "db_name": "uniprot", "db_id": "O14640" } ] }, { "id": "1.0alpha7.train.690.ent3_2", "type": "protein", "text": [ "Dvl" ], "offsets": [ [ 231, 234 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1855" }, { "db_name": "hgnc", "db_id": "DVL1" }, { "db_name": "uniprot", "db_id": "O14640" } ] }, { "id": "1.0alpha7.train.690.ent4_0", "type": "protein", "text": [ "Axin" ], "offsets": [ [ 136, 140 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8312" }, { "db_name": "hgnc", "db_id": "AXIN1" }, { "db_name": "uniprot", "db_id": "O15169" } ] }, { "id": "1.0alpha7.train.690.ent5_1", "type": "protein", "text": [ "Axin" ], "offsets": [ [ 239, 243 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8312" }, { "db_name": "hgnc", "db_id": "AXIN1" }, { "db_name": "uniprot", "db_id": "O15169" } ] }, { "id": "1.0alpha7.train.690.ent6_0", "type": "protein-domain", "text": [ "DIX" ], "offsets": [ [ 105, 108 ] ], "normalized": [] }, { "id": "1.0alpha7.train.690.ent7_0", "type": "protein-domain", "text": [ "PDZ" ], "offsets": [ [ 40, 43 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR001478" } ] } ]
[]
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1.0alpha7.train.691
24681740
[ { "id": "1.0alpha7.train.691.sent", "type": "sentence", "text": [ "The dissolution of this complex may result in the binding of eIF-4E to eIF-4G and the translational activation of CPE-containing mRNAs." ], "offsets": [ [ 0, 138 ] ] } ]
[ { "id": "1.0alpha7.train.691.ent0_0", "type": "RNA", "text": [ "CPE-containing mRNAs" ], "offsets": [ [ 117, 137 ] ], "normalized": [] }, { "id": "1.0alpha7.train.691.ent1_0", "type": "protein", "text": [ "eIF-4G" ], "offsets": [ [ 73, 79 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1981" }, { "db_name": "hgnc", "db_id": "EIF4G1" }, { "db_name": "uniprot", "db_id": "Q04637" } ] }, { "id": "1.0alpha7.train.691.ent2_0", "type": "RNA", "text": [ "CPE" ], "offsets": [ [ 117, 120 ] ], "normalized": [] }, { "id": "1.0alpha7.train.691.ent3_0", "type": "protein", "text": [ "eIF-4E" ], "offsets": [ [ 62, 68 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1977" }, { "db_name": "hgnc", "db_id": "EIF4E" }, { "db_name": "uniprot", "db_id": "P06730" } ] } ]
[]
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1.0alpha7.train.692
6656146
[ { "id": "1.0alpha7.train.692.sent", "type": "sentence", "text": [ "Our results strongly suggest that ATP bound mainly to the CI domain (Fig. 2) and that P loop 1 was a main active site for ATP-binding of KaiC." ], "offsets": [ [ 0, 147 ] ] } ]
[ { "id": "1.0alpha7.train.692.ent0_0", "type": "protein-domain", "text": [ "CI" ], "offsets": [ [ 60, 62 ] ], "normalized": [] }, { "id": "1.0alpha7.train.692.ent1_0", "type": "protein-motif", "text": [ "P loop 1" ], "offsets": [ [ 89, 97 ] ], "normalized": [] }, { "id": "1.0alpha7.train.692.ent2_0", "type": "protein", "text": [ "KaiC" ], "offsets": [ [ 142, 146 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q79PF4" } ] }, { "id": "1.0alpha7.train.692.ent3_0", "type": "chemical", "text": [ "ATP" ], "offsets": [ [ 35, 38 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5957" } ] }, { "id": "1.0alpha7.train.692.ent4_1", "type": "chemical", "text": [ "ATP" ], "offsets": [ [ 126, 129 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5957" } ] } ]
[]
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1.0alpha7.train.693
18145790
[ { "id": "1.0alpha7.train.693.sent", "type": "sentence", "text": [ "Interestingly, however, Shs1 can bind to Gin4 and induce Gin4 oligomerization under conditions in which the Cdc11 septin does not bind to Gin4, suggesting that Shs1 can function independently of the other septins. " ], "offsets": [ [ 0, 214 ] ] } ]
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[]
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1.0alpha7.train.694
1618474
[ { "id": "1.0alpha7.train.694.sent", "type": "sentence", "text": [ "Recently, several Sp1-related proteins, Sp2, Sp3, and Sp4, that bind to the GC box or GT motif were identified ( 33-35); however, their role in promoter regulation is less defined." ], "offsets": [ [ 0, 186 ] ] } ]
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[]
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1.0alpha7.train.695
12799747
[ { "id": "1.0alpha7.train.695.sent", "type": "sentence", "text": [ "To further show the specificity of Lef-1 binding to the siamois promoter we performed DNase I footprinting assays by use of Lef-1 HMG domain and the S1234 restriction fragment used in the band shift assays described above." ], "offsets": [ [ 0, 227 ] ] } ]
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[]
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1.0alpha7.train.696
16327158
[ { "id": "1.0alpha7.train.696.sent", "type": "sentence", "text": [ "To examine whether dcp-1 mutants were defective in the cytoskeletal reorganization in nurse cells, we stained egg chambers with rhodamine-phalloidin, which binds to filamentous actin (Fig. 4) ( 24)." ], "offsets": [ [ 0, 204 ] ] } ]
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[]
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1.0alpha7.train.697
13071194
[ { "id": "1.0alpha7.train.697.sent", "type": "sentence", "text": [ "GORLICH, D., P. HENKELIN, R. A. LASKEY, and E. HARTMANN, 1996 A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus." ], "offsets": [ [ 0, 173 ] ] } ]
[ { "id": "1.0alpha7.train.697.ent0_0", "type": "protein-family", "text": [ "importin-alpha" ], "offsets": [ [ 89, 103 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR024931" } ] }, { "id": "1.0alpha7.train.697.ent1_0", "type": "protein-family", "text": [ "importin-beta" ], "offsets": [ [ 124, 137 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR040122" } ] } ]
[]
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1.0alpha7.train.698
15793083
[ { "id": "1.0alpha7.train.698.sent", "type": "sentence", "text": [ "Rap1 binds to the HIS4 promoter and stimulates both Bas1/Bas2- and Gcn4-dependent HIS4 transcription two- to threefold, especially under uninduced conditions ( 6)." ], "offsets": [ [ 0, 168 ] ] } ]
[ { "id": "1.0alpha7.train.698.ent0_0", "type": "protein", "text": [ "Bas2" ], "offsets": [ [ 60, 64 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P90925" } ] }, { "id": "1.0alpha7.train.698.ent1_0", "type": "protein", "text": [ "Bas1" ], "offsets": [ [ 55, 59 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O45137" } ] }, { "id": "1.0alpha7.train.698.ent2_0", "type": "protein", "text": [ "Rap1" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5906" }, { "db_name": "hgnc", "db_id": "RAP1A" }, { "db_name": "uniprot", "db_id": "P62834" } ] }, { "id": "1.0alpha7.train.698.ent3_0", "type": "gene", "text": [ "HIS4" ], "offsets": [ [ 20, 24 ] ], "normalized": [] }, { "id": "1.0alpha7.train.698.ent4_1", "type": "gene", "text": [ "HIS4" ], "offsets": [ [ 87, 91 ] ], "normalized": [] }, { "id": "1.0alpha7.train.698.ent5_0", "type": "protein", "text": [ "Gcn4" ], "offsets": [ [ 71, 75 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P03069" } ] }, { "id": "1.0alpha7.train.698.ent6_0", "type": "DNA", "text": [ "HIS4 promoter" ], "offsets": [ [ 20, 33 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.699
5673641
[ { "id": "1.0alpha7.train.699.sent", "type": "sentence", "text": [ "Binding of p110C with PAK1 in Vivo" ], "offsets": [ [ 0, 34 ] ] } ]
[ { "id": "1.0alpha7.train.699.ent0_0", "type": "protein-region", "text": [ "p110C" ], "offsets": [ [ 11, 16 ] ], "normalized": [] }, { "id": "1.0alpha7.train.699.ent1_0", "type": "protein", "text": [ "PAK1" ], "offsets": [ [ 22, 26 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5058" }, { "db_name": "hgnc", "db_id": "PAK1" } ] } ]
[]
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1.0alpha7.train.700
11880659
[ { "id": "1.0alpha7.train.700.sent", "type": "sentence", "text": [ "In contrast to RabGDI, Ca2+/CaM does not discriminate between the GDP- and GTP-bound forms of Rab3." ], "offsets": [ [ 0, 103 ] ] } ]
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[]
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1.0alpha7.train.701
16569932
[ { "id": "1.0alpha7.train.701.sent", "type": "sentence", "text": [ "LPS-induced gene expression of TNF-alpha and IL-1beta is mediated by DNA-binding of NF-kappaB to the TNF-alpha and IL-1beta promotors ( 13)." ], "offsets": [ [ 0, 147 ] ] } ]
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[]
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1.0alpha7.train.702
1544659
[ { "id": "1.0alpha7.train.702.sent", "type": "sentence", "text": [ "We analyzed the effect of PKC phosphorylation on actin binding activities of A-fascin and wild-type r-fascin." ], "offsets": [ [ 0, 113 ] ] } ]
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[]
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1.0alpha7.train.703
25785599
[ { "id": "1.0alpha7.train.703.sent", "type": "sentence", "text": [ "The first lane shows a retardation caused by CREB binding to the CRE oligonucleotide in the absence of the antibody or its competitor oligonucleotide." ], "offsets": [ [ 0, 153 ] ] } ]
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[]
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1.0alpha7.train.704
23729666
[ { "id": "1.0alpha7.train.704.sent", "type": "sentence", "text": [ "Ca2+-dependent phospholipid and syntaxin binding by native synaptotagmins was examined essentially as described (Fernandez-Chacon et al., 2001 ), and bound proteins were analyzed by SDS-PAGE and immunoblotting." ], "offsets": [ [ 0, 215 ] ] } ]
[ { "id": "1.0alpha7.train.704.ent0_0", "type": "protein-family", "text": [ "syntaxin" ], "offsets": [ [ 33, 41 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR006011" } ] }, { "id": "1.0alpha7.train.704.ent1_0", "type": "chemical", "text": [ "Ca2+" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.704.ent2_0", "type": "chemical", "text": [ "phospholipid" ], "offsets": [ [ 15, 27 ] ], "normalized": [] }, { "id": "1.0alpha7.train.704.ent3_0", "type": "assay", "text": [ "SDS-PAGE" ], "offsets": [ [ 187, 195 ] ], "normalized": [] }, { "id": "1.0alpha7.train.704.ent4_0", "type": "protein-family", "text": [ "synaptotagmins" ], "offsets": [ [ 61, 75 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR001565" } ] } ]
[]
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1.0alpha7.train.705
1689192
[ { "id": "1.0alpha7.train.705.sent", "type": "sentence", "text": [ "To determine whether this tryptophan was required for Pbx1 and Meis1 cooperative binding to CRS1, tryptophan 213 of Meis1a, contained within the amino acid sequence, PSWNR was mutated to alanine." ], "offsets": [ [ 0, 201 ] ] } ]
[ { "id": "1.0alpha7.train.705.ent0_0", "type": "amino-acid", "text": [ "alanine" ], "offsets": [ [ 193, 200 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5950" } ] }, { "id": "1.0alpha7.train.705.ent1_0", "type": "protein", "text": [ "Meis1a" ], "offsets": [ [ 122, 128 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q7SZP3" } ] }, { "id": "1.0alpha7.train.705.ent2_0", "type": "protein-motif", "text": [ "PSWNR" ], "offsets": [ [ 172, 177 ] ], "normalized": [] }, { "id": "1.0alpha7.train.705.ent3_0", "type": "protein", "text": [ "Meis1" ], "offsets": [ [ 66, 71 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4211" }, { "db_name": "hgnc", "db_id": "MEIS1" }, { "db_name": "uniprot", "db_id": "O00470" } ] }, { "id": "1.0alpha7.train.705.ent4_0", "type": "protein", "text": [ "CRS1" ], "offsets": [ [ 96, 100 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7291" }, { "db_name": "hgnc", "db_id": "TWIST1" }, { "db_name": "uniprot", "db_id": "Q15672" } ] }, { "id": "1.0alpha7.train.705.ent5_0", "type": "amino-acid", "text": [ "tryptophan" ], "offsets": [ [ 27, 37 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6305" } ] }, { "id": "1.0alpha7.train.705.ent6_1", "type": "amino-acid", "text": [ "tryptophan" ], "offsets": [ [ 103, 113 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6305" } ] }, { "id": "1.0alpha7.train.705.ent7_0", "type": "protein", "text": [ "Pbx1" ], "offsets": [ [ 56, 60 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5087" }, { "db_name": "hgnc", "db_id": "PBX1" }, { "db_name": "uniprot", "db_id": "P40424" } ] } ]
[]
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1.0alpha7.train.706
1547022
[ { "id": "1.0alpha7.train.706.sent", "type": "sentence", "text": [ "Competition assays, tryptic digestion analyses, and direct binding analyses suggested that this was due to the H43Q mutation extensively reducing the affinity of binding of Csp to Hsc70." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "1.0alpha7.train.706.ent0_0", "type": "mutation", "text": [ "H43Q mutation" ], "offsets": [ [ 112, 125 ] ], "normalized": [] }, { "id": "1.0alpha7.train.706.ent1_0", "type": "protein", "text": [ "Csp" ], "offsets": [ [ 175, 178 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q03751" } ] }, { "id": "1.0alpha7.train.706.ent2_0", "type": "protein", "text": [ "Hsc70" ], "offsets": [ [ 183, 188 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3312" }, { "db_name": "hgnc", "db_id": "HSPA8" }, { "db_name": "uniprot", "db_id": "P11142" } ] } ]
[]
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1.0alpha7.train.707
4470330
[ { "id": "1.0alpha7.train.707.sent", "type": "sentence", "text": [ "Kinetics of Hsp70 Binding to the TNFα ARE" ], "offsets": [ [ 0, 41 ] ] } ]
[ { "id": "1.0alpha7.train.707.ent0_0", "type": "protein", "text": [ "Hsp70" ], "offsets": [ [ 12, 17 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3308" }, { "db_name": "hgnc", "db_id": "HSPA4" }, { "db_name": "uniprot", "db_id": "P34932" } ] }, { "id": "1.0alpha7.train.707.ent1_0", "type": "RNA", "text": [ "TNFα ARE" ], "offsets": [ [ 33, 41 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.709
12561638
[ { "id": "1.0alpha7.train.709.sent", "type": "sentence", "text": [ "Additional Fkh target sites identified with an extended Fkh-consensus binding site." ], "offsets": [ [ 0, 83 ] ] } ]
[ { "id": "1.0alpha7.train.709.ent0_0", "type": "protein-family", "text": [ "Fkh" ], "offsets": [ [ 11, 14 ] ], "normalized": [] }, { "id": "1.0alpha7.train.709.ent1_1", "type": "protein-family", "text": [ "Fkh" ], "offsets": [ [ 56, 59 ] ], "normalized": [] }, { "id": "1.0alpha7.train.709.ent2_0", "type": "DNA", "text": [ "Fkh-consensus binding site" ], "offsets": [ [ 56, 82 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.710
19709836
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[]
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1.0alpha7.train.711
8949460
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1.0alpha7.train.712
15397588
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[]
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1.0alpha7.train.713
6888373
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[]
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1.0alpha7.train.714
4320036
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1.0alpha7.train.715
25325675
[ { "id": "1.0alpha7.train.715.sent", "type": "sentence", "text": [ "In the current work, we demonstrate that RDGC binds to calmodulin, and a mutation in an IQ motif that eliminates the calmodulin/ RDGC interaction prevents dephosphorylation of rhodopsin in vivo and disrupts termination of the photoresponse." ], "offsets": [ [ 0, 245 ] ] } ]
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[]
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1.0alpha7.train.716
4876074
[ { "id": "1.0alpha7.train.716.sent", "type": "sentence", "text": [ "Whereas the binding of ATP had no effect on the binding of IkappaBalpha peptide for the rhIKK-1/rhIKK-2 heterodimer, the binding of ATP decreased the affinity of IkappaBalpha peptide for rhIKK-i and rhTBK-1." ], "offsets": [ [ 0, 211 ] ] } ]
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[]
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1.0alpha7.train.717
12497152
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[]
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1.0alpha7.train.718
11325324
[ { "id": "1.0alpha7.train.718.sent", "type": "sentence", "text": [ "Thus, MSL2 and MSL1 may comprise the chromatin-binding activity of the MSL complex, or may be the first of the known subunits to assemble at pre-defined sites." ], "offsets": [ [ 0, 163 ] ] } ]
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[]
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[]
1.0alpha7.train.719
9496081
[ { "id": "1.0alpha7.train.719.sent", "type": "sentence", "text": [ "First, which event(s) in the formation of clathrin-coated vesicles are regulated by the GTP-bound form of dynamin?" ], "offsets": [ [ 0, 117 ] ] } ]
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[]
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1.0alpha7.train.720
25325696
[ { "id": "1.0alpha7.train.720.sent", "type": "sentence", "text": [ "RDGC Bound Directly to Calmodulin" ], "offsets": [ [ 0, 33 ] ] } ]
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[]
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1.0alpha7.train.721
22874001
[ { "id": "1.0alpha7.train.721.sent", "type": "sentence", "text": [ "The C-terminal C2 domain (C2-B) has been shown to bind a clathrin-coated vesicle protein complex (AP-2) and syntaxins (Zhang et al., 1994 ; Li et al., 1995 ); all known synaptotagmins bind AP-2 and syntaxin." ], "offsets": [ [ 0, 216 ] ] } ]
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[]
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1.0alpha7.train.722
25311172
[ { "id": "1.0alpha7.train.722.sent", "type": "sentence", "text": [ "As previously reported, CSP also binds to Hsc70 (right diagram, col." ], "offsets": [ [ 0, 70 ] ] } ]
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[]
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1.0alpha7.train.723
23643570
[ { "id": "1.0alpha7.train.723.sent", "type": "sentence", "text": [ "Activators of endogenous PKA that stimulate dSlo phosphorylation, but do not produce detectable PKAc binding to dSlo, do not modulate channel function." ], "offsets": [ [ 0, 155 ] ] } ]
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[]
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1.0alpha7.train.724
22268810
[ { "id": "1.0alpha7.train.724.sent", "type": "sentence", "text": [ "GTP-bound forms of Rho associated with GST-rhotekin-RBD were released from beads by an addition of protein loading buffer, and quantified by Western blot analysis using AU5 antibodies." ], "offsets": [ [ 0, 186 ] ] } ]
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[]
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1.0alpha7.train.725
4666737
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[]
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1.0alpha7.train.726
15882165
[ { "id": "1.0alpha7.train.726.sent", "type": "sentence", "text": [ "( GA) enhances the heat-inducible HSE-binding activity of HSF1 and delays deactivation during recovery." ], "offsets": [ [ 0, 105 ] ] } ]
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[]
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1.0alpha7.train.727
15658366
[ { "id": "1.0alpha7.train.727.sent", "type": "sentence", "text": [ "These results show that DDP1 binds the dodeca-satellite C strand with a higher affinity than the vigilin binding sites of the Xenopus vitellogenin and human dystrophin mRNAs." ], "offsets": [ [ 0, 180 ] ] } ]
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[]
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1.0alpha7.train.728
563736
[ { "id": "1.0alpha7.train.728.sent", "type": "sentence", "text": [ "For precipitation with GST fusion proteins, lysates from control or IFN-treated Daudi cells were precipitated with STAT3-GST or GST bound to glutathione-agarose beads." ], "offsets": [ [ 0, 175 ] ] } ]
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[]
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[]
1.0alpha7.train.729
2173067
[ { "id": "1.0alpha7.train.729.sent", "type": "sentence", "text": [ "Binding of native synaptotagmin and AP-2 was assayed by immunoblot analysis." ], "offsets": [ [ 0, 78 ] ] } ]
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[]
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[]
1.0alpha7.train.730
9372597
[ { "id": "1.0alpha7.train.730.sent", "type": "sentence", "text": [ "Only nonphosphorylated Kelch (KelY627A) bound actin ( Fig. 2 I)." ], "offsets": [ [ 0, 66 ] ] } ]
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[]
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1.0alpha7.train.731
1686299
[ { "id": "1.0alpha7.train.731.sent", "type": "sentence", "text": [ "Thus, FLI bound actin specifically." ], "offsets": [ [ 0, 37 ] ] } ]
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[]
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1.0alpha7.train.732
11328193
[ { "id": "1.0alpha7.train.732.sent", "type": "sentence", "text": [ "We have derived a consensus sequence from this data which predicts high-affinity binding of a subset of PH domains to PI3K products and have proposed a model for how these PH domains bind PI3K products with high affinity." ], "offsets": [ [ 0, 225 ] ] } ]
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[]
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1.0alpha7.train.733
13041170
[ { "id": "1.0alpha7.train.733.sent", "type": "sentence", "text": [ "PcG proteins bind to PREs in vivo and package the adjacent chromatin into a closed repressed conformation." ], "offsets": [ [ 0, 108 ] ] } ]
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[]
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1.0alpha7.train.734
9382722
[ { "id": "1.0alpha7.train.734.sent", "type": "sentence", "text": [ "The JM domain is known to have the site to which p120ctn binds, that is, the JM(-) cadherin cannot bind to this catenin (Yap et al., 1998; Ohkubo and Ozawa, 1999; Thoreson et al., 2000)." ], "offsets": [ [ 0, 186 ] ] } ]
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[]
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1.0alpha7.train.735
3791724
[ { "id": "1.0alpha7.train.735.sent", "type": "sentence", "text": [ "X11α Binding to CCS Is Mediated by PDZ2 and Sequences within CCS Domain III" ], "offsets": [ [ 0, 75 ] ] } ]
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[]
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1.0alpha7.train.737
8949394
[ { "id": "1.0alpha7.train.737.sent", "type": "sentence", "text": [ "Amino acids 109 - 295 of LIN-7 could bind LIN-2, but amino acids 126 - 295 or the PDZ domain of LIN-7 could not bind LIN-2 ( Figure 5A)." ], "offsets": [ [ 0, 144 ] ] } ]
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[]
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1.0alpha7.train.738
11977623
[ { "id": "1.0alpha7.train.738.sent", "type": "sentence", "text": [ "( C) Asp38 is not required for binding of Par6 to Cdc42." ], "offsets": [ [ 0, 58 ] ] } ]
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[]
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1.0alpha7.train.739
6619022
[ { "id": "1.0alpha7.train.739.sent", "type": "sentence", "text": [ "The SH3 Domain of Abl Also Binds to Cbl." ], "offsets": [ [ 0, 40 ] ] } ]
[ { "id": "1.0alpha7.train.739.ent0_0", "type": "protein", "text": [ "Abl" ], "offsets": [ [ 18, 21 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P00522" } ] }, { "id": "1.0alpha7.train.739.ent1_0", "type": "protein", "text": [ "Cbl" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "867" }, { "db_name": "hgnc", "db_id": "CBL" }, { "db_name": "uniprot", "db_id": "P22681" } ] }, { "id": "1.0alpha7.train.739.ent2_0", "type": "protein-domain", "text": [ "SH3 Domain" ], "offsets": [ [ 4, 14 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR001452" } ] } ]
[]
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1.0alpha7.train.741
790272
[ { "id": "1.0alpha7.train.741.sent", "type": "sentence", "text": [ "Full-length TRAF2 and the complete TRAF domain bound specifically to TRADD." ], "offsets": [ [ 0, 78 ] ] } ]
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[]
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1.0alpha7.train.742
12454833
[ { "id": "1.0alpha7.train.742.sent", "type": "sentence", "text": [ "We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 )." ], "offsets": [ [ 0, 176 ] ] } ]
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[]
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1.0alpha7.train.743
1686283
[ { "id": "1.0alpha7.train.743.sent", "type": "sentence", "text": [ "To determine if FLI is an actin-binding protein, FLI and the FLI LRR domain (Fig.1 A) were expressed by in vitro transcription and translation (Fig. 1 B)." ], "offsets": [ [ 0, 154 ] ] } ]
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[]
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1.0alpha7.train.744
3807106
[ { "id": "1.0alpha7.train.744.sent", "type": "sentence", "text": [ "However, when SRF is bound to SRE as a dimer it is accessible to make tertiary complex with Ets members, as reported before, but not to TEF-1." ], "offsets": [ [ 0, 146 ] ] } ]
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[]
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1.0alpha7.train.745
22679848
[ { "id": "1.0alpha7.train.745.sent", "type": "sentence", "text": [ "Although the Hsp70 used contained low levels of endotoxin (<0.5 EU/mg as assessed by the limulus amebocyte lysate assay), we excluded a potential involvement of residual endotoxin in Hsp70 binding to APC based on the following observations." ], "offsets": [ [ 0, 240 ] ] } ]
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[]
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1.0alpha7.train.746
2145856
[ { "id": "1.0alpha7.train.746.sent", "type": "sentence", "text": [ "Also, the VIP1R antagonist blocked the effect of VIP/ PACAP on both NF-kB and c-Jun/ CREB binding to the TNFalpha promoter, supporting the involvement of the VIP1R in the regulatory effect of VIP/ PACAP on TNFalpha gene expression." ], "offsets": [ [ 0, 239 ] ] } ]
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[]
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1.0alpha7.train.747
1396973
[ { "id": "1.0alpha7.train.747.sent", "type": "sentence", "text": [ "Our findings so far have indicated that oligo II can bind NF1, CP1, and SP1, and the binding of NF1 and CP1 to footprint II is mutually exclusive ( 7, 8)." ], "offsets": [ [ 0, 160 ] ] } ]
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[]
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1.0alpha7.train.748
15918642
[ { "id": "1.0alpha7.train.748.sent", "type": "sentence", "text": [ "Interestingly, the recombinant 14-3-3 had two effects: it reduced the amount of Raf-1 that bound to the Ras membranes but increased the specific activity of membrane-bound Raf-1 (Fig. ​5A and C)." ], "offsets": [ [ 0, 195 ] ] } ]
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[]
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1.0alpha7.train.749
7146173
[ { "id": "1.0alpha7.train.749.sent", "type": "sentence", "text": [ "Moreover, a recent study ( 33) examined the effect of temperature on the oxygen-binding properties of the Hbs of three notothenioid fish species." ], "offsets": [ [ 0, 147 ] ] } ]
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[]
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1.0alpha7.train.750
17525094
[ { "id": "1.0alpha7.train.750.sent", "type": "sentence", "text": [ "The “active” lipids include both esterified and unesterified peroxidized lipids, lysoPtdCho, cholesterol oxidation products, aldehydes derived from breakdown of both esterified and unesterified oxidized fatty acids, and perhaps proteolipids that may have peroxidized lipids bound to fragmented apoB-100." ], "offsets": [ [ 0, 303 ] ] } ]
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[]
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[]
1.0alpha7.train.751
5105284
[ { "id": "1.0alpha7.train.751.sent", "type": "sentence", "text": [ "Loss of Fused kinase activity or loss of the serine 931 phosphorylation site could reduce Ci binding to Cos2, which could, in turn, reduce Ci processing by preventing the processing enzyme from interacting with Ci." ], "offsets": [ [ 0, 220 ] ] } ]
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[]
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1.0alpha7.train.752
12471371
[ { "id": "1.0alpha7.train.752.sent", "type": "sentence", "text": [ "( C) dFOXO binds specifically to d4EBP and dInR promoters in vivo." ], "offsets": [ [ 0, 70 ] ] } ]
[ { "id": "1.0alpha7.train.752.ent0_0", "type": "DNA", "text": [ "d4EBP" ], "offsets": [ [ 36, 41 ] ], "normalized": [] }, { "id": "1.0alpha7.train.752.ent1_0", "type": "protein", "text": [ "dFOXO" ], "offsets": [ [ 6, 11 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q95V55" } ] }, { "id": "1.0alpha7.train.752.ent2_0", "type": "DNA", "text": [ "dInR promoters" ], "offsets": [ [ 47, 61 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.753
3701744
[ { "id": "1.0alpha7.train.753.sent", "type": "sentence", "text": [ "We have identified several amino acids, distinct from the MIDAS residues, which are critical for alpha2-I domain binding to collagen." ], "offsets": [ [ 0, 136 ] ] } ]
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[]
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1.0alpha7.train.754
12471396
[ { "id": "1.0alpha7.train.754.sent", "type": "sentence", "text": [ "Furthermore, dFOXO binding to the d4EBP promoter fragment can be efficiently competed with an unlabeled 113-bp d4EBP promoter fragment ( Fig. 5B, lanes 9 - 12) but not with nonspecific DNA ( Fig. 5B, lanes 13 - 16)." ], "offsets": [ [ 0, 222 ] ] } ]
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[]
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1.0alpha7.train.755
5874143
[ { "id": "1.0alpha7.train.755.sent", "type": "sentence", "text": [ "We expect that in the intact BAF complex, the actin monomer is bound to Brg1 at both of these sites." ], "offsets": [ [ 0, 100 ] ] } ]
[ { "id": "1.0alpha7.train.755.ent0_0", "type": "protein-complex", "text": [ "BAF complex" ], "offsets": [ [ 29, 40 ] ], "normalized": [] }, { "id": "1.0alpha7.train.755.ent1_0", "type": "protein", "text": [ "Brg1" ], "offsets": [ [ 72, 76 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6597" }, { "db_name": "hgnc", "db_id": "SMARCA4" }, { "db_name": "uniprot", "db_id": "P51532" } ] }, { "id": "1.0alpha7.train.755.ent2_0", "type": "protein", "text": [ "actin" ], "offsets": [ [ 46, 51 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "58" }, { "db_name": "hgnc", "db_id": "ACTA1" }, { "db_name": "uniprot", "db_id": "P68133" } ] } ]
[]
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1.0alpha7.train.756
12692896
[ { "id": "1.0alpha7.train.756.sent", "type": "sentence", "text": [ "In the absence of a functional Exd half-site, the Hox half-site in fkh[250] weakly binds several Hox proteins, but when the Exd half-site is functional, one of these Hox proteins (Scr) binds better than the others; thus, Exd selectively enhances the binding of one Hox protein over the others." ], "offsets": [ [ 0, 293 ] ] } ]
[ { "id": "1.0alpha7.train.756.ent0_0", "type": "protein-family", "text": [ "fkh" ], "offsets": [ [ 67, 70 ] ], "normalized": [] }, { "id": "1.0alpha7.train.756.ent1_0", "type": "protein", "text": [ "Exd" ], "offsets": [ [ 31, 34 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P40427" } ] }, { "id": "1.0alpha7.train.756.ent2_1", "type": "protein", "text": [ "Exd" ], "offsets": [ [ 124, 127 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P40427" } ] }, { "id": "1.0alpha7.train.756.ent3_2", "type": "protein", "text": [ "Exd" ], "offsets": [ [ 221, 224 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P40427" } ] }, { "id": "1.0alpha7.train.756.ent4_0", "type": "protein", "text": [ "Scr" ], "offsets": [ [ 180, 183 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P09077" } ] }, { "id": "1.0alpha7.train.756.ent5_0", "type": "protein-family", "text": [ "Hox" ], "offsets": [ [ 50, 53 ] ], "normalized": [] }, { "id": "1.0alpha7.train.756.ent6_1", "type": "protein-family", "text": [ "Hox" ], "offsets": [ [ 97, 100 ] ], "normalized": [] }, { "id": "1.0alpha7.train.756.ent7_2", "type": "protein-family", "text": [ "Hox" ], "offsets": [ [ 166, 169 ] ], "normalized": [] }, { "id": "1.0alpha7.train.756.ent8_3", "type": "protein-family", "text": [ "Hox" ], "offsets": [ [ 265, 268 ] ], "normalized": [] }, { "id": "1.0alpha7.train.756.ent9_0", "type": "protein-family", "text": [ "Hox proteins" ], "offsets": [ [ 97, 109 ] ], "normalized": [] }, { "id": "1.0alpha7.train.756.ent10_1", "type": "protein-family", "text": [ "Hox proteins" ], "offsets": [ [ 166, 178 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.756.coref0", "entity_ids": [ "1.0alpha7.train.756.ent0_0" ] }, { "id": "1.0alpha7.train.756.coref1", "entity_ids": [ "1.0alpha7.train.756.ent1_0", "1.0alpha7.train.756.ent2_1", "1.0alpha7.train.756.ent3_2" ] }, { "id": "1.0alpha7.train.756.coref2", "entity_ids": [ "1.0alpha7.train.756.ent4_0" ] }, { "id": "1.0alpha7.train.756.coref3", "entity_ids": [ "1.0alpha7.train.756.ent5_0", "1.0alpha7.train.756.ent6_1", "1.0alpha7.train.756.ent7_2", "1.0alpha7.train.756.ent8_3", "1.0alpha7.train.756.ent9_0", "1.0alpha7.train.756.ent10_1" ] } ]
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1.0alpha7.train.757
18999167
[ { "id": "1.0alpha7.train.757.sent", "type": "sentence", "text": [ "We did find, instead, an increased binding of GSK-3β to E-cadherin and β-catenin." ], "offsets": [ [ 0, 81 ] ] } ]
[ { "id": "1.0alpha7.train.757.ent0_0", "type": "protein-family", "text": [ "β-catenin" ], "offsets": [ [ 71, 80 ] ], "normalized": [] }, { "id": "1.0alpha7.train.757.ent1_0", "type": "protein", "text": [ "E-cadherin" ], "offsets": [ [ 56, 66 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "999" }, { "db_name": "hgnc", "db_id": "CDH1" }, { "db_name": "uniprot", "db_id": "P12830" } ] }, { "id": "1.0alpha7.train.757.ent2_0", "type": "protein", "text": [ "GSK-3β" ], "offsets": [ [ 46, 52 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2931" }, { "db_name": "hgnc", "db_id": "GSK3A" }, { "db_name": "uniprot", "db_id": "P49840" } ] } ]
[]
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1.0alpha7.train.758
9568654
[ { "id": "1.0alpha7.train.758.sent", "type": "sentence", "text": [ "Synaptotagmin binds beta-SNAP, but not alpha-SNAP, with a high degree of selectivity ( Schiavo et al. 1995 ); however, the physiological function of this interaction has yet to be established." ], "offsets": [ [ 0, 196 ] ] } ]
[ { "id": "1.0alpha7.train.758.ent0_0", "type": "protein", "text": [ "SNAP" ], "offsets": [ [ 26, 30 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6616" }, { "db_name": "hgnc", "db_id": "SNAP25" }, { "db_name": "uniprot", "db_id": "P60880" } ] }, { "id": "1.0alpha7.train.758.ent1_1", "type": "protein", "text": [ "SNAP" ], "offsets": [ [ 47, 51 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6616" }, { "db_name": "hgnc", "db_id": "SNAP25" }, { "db_name": "uniprot", "db_id": "P60880" } ] }, { "id": "1.0alpha7.train.758.ent2_0", "type": "protein-isoform", "text": [ "alpha-SNAP" ], "offsets": [ [ 41, 51 ] ], "normalized": [] }, { "id": "1.0alpha7.train.758.ent3_0", "type": "protein-family", "text": [ "Synaptotagmin" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR001565" } ] }, { "id": "1.0alpha7.train.758.ent4_0", "type": "protein-isoform", "text": [ "beta-SNAP" ], "offsets": [ [ 21, 30 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.758.coref0", "entity_ids": [ "1.0alpha7.train.758.ent0_0", "1.0alpha7.train.758.ent1_1" ] }, { "id": "1.0alpha7.train.758.coref1", "entity_ids": [ "1.0alpha7.train.758.ent2_0" ] }, { "id": "1.0alpha7.train.758.coref2", "entity_ids": [ "1.0alpha7.train.758.ent3_0" ] }, { "id": "1.0alpha7.train.758.coref3", "entity_ids": [ "1.0alpha7.train.758.ent4_0" ] } ]
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1.0alpha7.train.759
11323571
[ { "id": "1.0alpha7.train.759.sent", "type": "sentence", "text": [ "They also confirmed our finding (Klotzbucher et al., 1996 ) that the D-box of cyclin A does not behave as a transportable module; indeed, we concluded that cyclin A must be bound to Cdc2 or CDK2 in order to be degraded." ], "offsets": [ [ 0, 225 ] ] } ]
[ { "id": "1.0alpha7.train.759.ent0_0", "type": "protein-domain", "text": [ "D-box" ], "offsets": [ [ 71, 76 ] ], "normalized": [] }, { "id": "1.0alpha7.train.759.ent1_0", "type": "protein", "text": [ "Cdc2" ], "offsets": [ [ 187, 191 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "983" }, { "db_name": "hgnc", "db_id": "CDK1" }, { "db_name": "uniprot", "db_id": "P06493" } ] }, { "id": "1.0alpha7.train.759.ent2_0", "type": "protein", "text": [ "CDK2" ], "offsets": [ [ 196, 200 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1017" }, { "db_name": "hgnc", "db_id": "CDK2" }, { "db_name": "uniprot", "db_id": "P24941" } ] }, { "id": "1.0alpha7.train.759.ent3_0", "type": "protein-family", "text": [ "cyclin A" ], "offsets": [ [ 81, 89 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR032447" } ] }, { "id": "1.0alpha7.train.759.ent4_1", "type": "protein-family", "text": [ "cyclin A" ], "offsets": [ [ 160, 168 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR032447" } ] } ]
[]
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1.0alpha7.train.760
12213501
[ { "id": "1.0alpha7.train.760.sent", "type": "sentence", "text": [ "The acquired thermotolerance may thus result from the higher content of HSP70 and a subsequent more extensive binding of HSP70 to F-actin in the primed cells." ], "offsets": [ [ 0, 161 ] ] } ]
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1.0alpha7.train.761
11484232
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[]
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[]
1.0alpha7.train.762
2887918
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[]
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1.0alpha7.train.763
3410108
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[]
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1.0alpha7.train.764
1932402
[ { "id": "1.0alpha7.train.764.sent", "type": "sentence", "text": [ "Thus, the combination of exclusive binding of p50 cdc37 versus a TPR domain protein to hsp90 plus direct binding of p50 cdc37 to Raf allow the protein kinase to determine the dominant heterocomplex composition." ], "offsets": [ [ 0, 215 ] ] } ]
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[]
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1.0alpha7.train.765
25785654
[ { "id": "1.0alpha7.train.765.sent", "type": "sentence", "text": [ "No information, however, has been available concerning the effects of sustained ischemia on the CRE-DNA binding activity of CREB in the brain." ], "offsets": [ [ 0, 145 ] ] } ]
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[]
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1.0alpha7.train.766
16171652
[ { "id": "1.0alpha7.train.766.sent", "type": "sentence", "text": [ "Nidogen can bind collagen type IV, fibulins, laminin, and perlecan ( 10, 18, 19)." ], "offsets": [ [ 0, 86 ] ] } ]
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[]
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1.0alpha7.train.767
4222009
[ { "id": "1.0alpha7.train.767.sent", "type": "sentence", "text": [ "Together, these findings indicate that NIK binds directly to NHE1 at a site located between amino acids 538 and 638 in the C-terminal domain." ], "offsets": [ [ 0, 143 ] ] } ]
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[]
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1.0alpha7.train.768
20400998
[ { "id": "1.0alpha7.train.768.sent", "type": "sentence", "text": [ "Bosselut,R., Levin,J., Adjadj,E. and Ghysdael,J. (1993) A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74." ], "offsets": [ [ 0, 214 ] ] } ]
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[]
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1.0alpha7.train.769
11270805
[ { "id": "1.0alpha7.train.769.sent", "type": "sentence", "text": [ "The results above show that AEF-1 binding to the proximal Inr region represses transcription." ], "offsets": [ [ 0, 95 ] ] } ]
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[]
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1.0alpha7.train.770
19321212
[ { "id": "1.0alpha7.train.770.sent", "type": "sentence", "text": [ "Further analysis of the amino-terminal region of Smo in BCCs may lead to the identification of oncogenic mutations disrupting the binding of Smo to Ptc." ], "offsets": [ [ 0, 156 ] ] } ]
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[]
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1.0alpha7.train.771
11286119
[ { "id": "1.0alpha7.train.771.sent", "type": "sentence", "text": [ "Full‐length eIF4G binds PABP" ], "offsets": [ [ 0, 28 ] ] } ]
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[]
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1.0alpha7.train.772
12031487
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[]
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1.0alpha7.train.773
2399890
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[]
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1.0alpha7.train.774
2723332
[ { "id": "1.0alpha7.train.774.sent", "type": "sentence", "text": [ "Stable F-actin binding can only take place at low pH values where cofilin binds actin monomers within the filament via site 1 and site 2." ], "offsets": [ [ 0, 139 ] ] } ]
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[]
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1.0alpha7.train.775
15399923
[ { "id": "1.0alpha7.train.775.sent", "type": "sentence", "text": [ "dASF1 binds directly to dCAF-1." ], "offsets": [ [ 0, 32 ] ] } ]
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[]
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1.0alpha7.train.776
25325707
[ { "id": "1.0alpha7.train.776.sent", "type": "sentence", "text": [ "Binding of RDGC to calmodulin-agarose was not strictly Ca2+ dependent." ], "offsets": [ [ 0, 72 ] ] } ]
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[]
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1.0alpha7.train.777
15911142
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[]
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1.0alpha7.train.778
15877979
[ { "id": "1.0alpha7.train.778.sent", "type": "sentence", "text": [ "Furthermore, when the C-terminal 194 residues were deleted, E6TP1 could not bind to E6." ], "offsets": [ [ 0, 89 ] ] } ]
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[]
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1.0alpha7.train.779
696960
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