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Map Adverse Drug Events (ADEs) mentioned in text data to their most relevant Preferred MeDDRA terms.
We present a case of a 58-year-old female patient with Graves' disease who developed AA in the third exposure to methimazole (MMI).
Aplastic Anaemia
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FSGS induced by Adriamycin (Pharmacia & Upjohn, Columbus, OH) has been observed experimentally in rats.
Focal segmental glomerulosclerosis
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The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.
Tubulointerstitial nephritis
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Tubulointerstitial nephritis induced by the leukotriene receptor antagonist pranlukast.
Tubulointerstitial nephritis
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Within 6 months of pranlukast withdrawal, anemia resolved and urinary sediment and renal function normalized.
Anaemia
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A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate (5 mg).
Syncope
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Elderly patients for whom nitrate has been prescribed should be warned of the occurrence of hypotension, leading to unconsciousness.
Hypotension
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In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.
Blood pressure decreased
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Syncope in a 65-year-old woman after nitrate ingestion.
Syncope
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Three diabetic cases of acute dizziness due to initial administration of voglibose.
Dizziness
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We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.
Dizziness
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Naproxen-associated sudden sensorineural hearing loss.
Deafness neurosensory
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Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss.
Tinnitus
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This article reports the case of an otherwise healthy patient who experienced permanent sensorineural hearing loss after a brief course of naproxen and reviews the literature on NSAID-related permanent sensorineural hearing loss.
Deafness neurosensory
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Dental and gingival pain as side effects of niacin therapy.
Gingival pain
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The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.
Hyperaesthesia
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Two 65-year-old white men with coronary heart disease, given niacin therapy for dyslipidemia for 5 months, developed intense dental and gingival pain that was associated with increases in dose and that was relieved with discontinuance of niacin treatment.
Gingival pain
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Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.
Hypokalaemia
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High-dose phosphate treatment leads to hypokalemia in hypophosphatemic osteomalacia.
Hypokalaemia
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It was concluded that potassium loss occurred by a non-renal (intestinal) route in phosphate-induced hypokalemia.
Hypokalaemia
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Progressive hypokalemia developed during phosphate treatment.
Hypokalaemia
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The mechanism of the decrease in plasma potassium induced by phosphate treatment was investigated in a 24-year-old hypertensive patient with hypophosphatemic osteomalacia, who was the youngest of four patients, belonging to a 23 number kindred of five generations.
decrease in plasma potassium
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Transtubular potassium gradient (TTKG) also decreased and an inverse correlation was found between TTKG and doses of phosphate (r = -0.37; p < 0.02; N = 38).
Hypokalaemia
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Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.
Interstitial lung disease
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The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure.
Pulmonary toxicity
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We report a case of severe respiratory failure due to gold salt toxicity in a patient suffering from rheumatoid arthritis requiring mechanical ventilation.
Respiratory failure
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As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.
Hypersensitivity
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A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.
Glycosuria
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A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.
Hyperglycaemia
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After 1 week of nefazodone therapy the patient experienced headache, confusion, and "gray areas" in her vision, without abnormal ophthalmologic findings.
Confusional state
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Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.
Drug interaction
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Interaction between tacrolimus and nefazodone in a stable renal transplant recipient.
Drug interaction
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We suspect that nefazodone inhibits metabolism of tacrolimus.
Drug interaction
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We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia.
Poisoning
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CONCLUSION: We report a case of the use of pamidronate for significant hypercalcemia secondary to acute vitamin D poisoning.
Toxicity to various agents
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Pamidronate therapy should be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.
Toxicity to various agents
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The patient was initially treated with hydration and furosemide but developed congestive heart failure.
Cardiac failure congestive
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The use of pamidronate for hypercalcemia secondary to acute vitamin D intoxication.
Toxicity to various agents
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We report the use of pamidronate for acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning.
Hypercalcaemia
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A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis.
Hepatic necrosis
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Methotrexate-induced hepatic necrosis requiring liver transplantation in a patient with rheumatoid arthritis.
Hepatic necrosis
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MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis.
Drug-induced Liver injury
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Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia.
Hypokalaemia
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CONCLUSIONS: Because of its structural similarity to the other vinca alkaloids, vinorelbine is believed to be responsible for SIADH in our patient.
Inappropriate antidiuretic hormone secretion
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OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.
Inappropriate antidiuretic hormone secretion
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Syndrome of inappropriate antidiuretic hormone associated with vinorelbine therapy.
Inappropriate antidiuretic hormone secretion
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Pirmenol hydrochloride-induced QT prolongation and T wave inversion on electrocardiogram during treatment for symptomatic atrial fibrillation.
Torsade de pointes
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Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram.
Torsade de pointes
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We report on a 56-year-old female who exhibited drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion on electrocardiogram was demonstrated reproducibly shortly after the administration of oral pirmenol therapy.
Torsade de pointes
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Disseminated muscular cysticercosis with myositis induced by praziquantel therapy.
Myositis
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We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.
Myalgia
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Massive subfascial hematoma after alteplase therapy for acute myocardial infarction.
Haematoma
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Physicians should be aware of the possible association between the use of alteplase and the development of subfascial hemorrhage.
Haematoma
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The authors report a case of a patient who received alteplase for acute myocardial infarction and developed spontaneous subfascial hematoma without any evidence of direct trauma.
Haematoma
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The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.
Ecchymosis
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A fatal case of pancytopenia due to levomepromazine.
Pancytopenia
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A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.
Pancytopenia
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Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.
Hyperthyroidism
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Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).
Hyperthyroidism
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Since amiodarone was first marketed in 1992 in Japan, the incidence of amiodarone-induced thyrotoxicosis (AIT) has been increasing.
Autoimmune thyroiditis
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These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.
Thyroiditis
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CONCLUSION: Lipoid pneumonia as a result of mineral oil aspiration still occurs in the pediatric population.
Pneumonia lipoid
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Lipoid pneumonia: a silent complication of mineral oil aspiration.
Pneumonia lipoid
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Our case points to the need for increased awareness by the general pediatricians of the potential hazards of mineral oil use for chronic constipation.
Adverse event
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An unusual cause of burn injury: unsupervised use of drugs that contain psoralens.
Photosensitivity reaction
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Because psoralens sensitize skin to ultraviolet A light, phototoxic reactions are the most frequent adverse effect of this treatment.
Photosensitivity reaction
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In this article, we present the case of a vitiligo patient who was admitted to our facility with an intense burn after the topical use of 8-methoxypsoralen solution as a suntanning agent.
Thermal burn
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Sunburn may sometimes be a major injury in psoralen users because high doses or inappropriate use of the drug may render the skin extremely sensitive.
Dermatitis allergic
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CONCLUSIONS: Metoclopramide may cause reversible nonthrombocytopenic vascular-type palpable purpura.
Palpable purpura
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OBJECTIVE: To report a case of reversible nonthrombocytopenic palpable purpura associated with metoclopramide.
Palpable purpura
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Reversible nonthrombocytopenic palpable purpura associated with metoclopramide.
Palpable purpura
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Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.
Diabetes insipidus
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Eosinophilia caused by clozapine was observed in challenge, preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01).
Eosinophilia
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Eosinophilia has been encountered from 0.2 to 61.7% in clozapine-treated patients, mostly with a transient course and spontaneous remission.
Eosinophilia
null
Successful challenge with clozapine in a history of eosinophilia.
Eosinophilia