mihirhirave/entity_extraction_ade_v2_with_validation

text stringlengths 22 455	relations listlengths 1 24
A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside.	[ { "ade": "hyponatremia", "drug": "adenine arabinoside" }, { "ade": "syndrome of inappropriate antidiuretic hormone", "drug": "adenine arabinoside" } ]
We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.	[ { "ade": "hypoalbuminaemia", "drug": "insulin" }, { "ade": "hyperinsulinaemia", "drug": "insulin" }, { "ade": "anti-natriuresis", "drug": "insulin" }, { "ade": "increased vascular permeability", "drug": "insulin" }, { "ade": "insulin insensitivity", "drug": "insulin" } ]
Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features.	[ { "ade": "retroperitoneal fibrosis", "drug": "Methysergide" } ]
Pulmonary toxicity associated with erlotinib.	[ { "ade": "Pulmonary toxicity", "drug": "erlotinib" } ]
Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta.	[ { "ade": "inflammatory arthritis", "drug": "IFN-beta" } ]
Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram.	[ { "ade": "T wave inversion", "drug": "pirmenol" }, { "ade": "QT prolongation", "drug": "pirmenol" } ]
Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.	[ { "ade": "general erythema", "drug": "cisplatin" }, { "ade": "abdominal pain", "drug": "cisplatin" }, { "ade": "dyspnea", "drug": "cisplatin" }, { "ade": "fever", "drug": "cisplatin" }, { "ade": "hypotension", "drug": "cisplatin" }, { "ade": "hypersensitivity reactions", "drug": "cisplatin" } ]
OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.	[ { "ade": "lipoatrophy", "drug": "human insulin" } ]
Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia.	[ { "ade": "hypokalemia", "drug": "vinorelbine" }, { "ade": "SIADH", "drug": "vinorelbine" } ]
From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).	[ { "ade": "renal colic", "drug": "indinavir" }, { "ade": "fever", "drug": "indinavir" }, { "ade": "cutaneous rash", "drug": "nelfinavir" }, { "ade": "nausea", "drug": "efavirenz" }, { "ade": "temporary memory loss", "drug": "efavirenz" } ]
The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment.	[ { "ade": "DIC", "drug": "anti-D IGIV" } ]
Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms.	[ { "ade": "carcinogenic", "drug": "Tamoxifen" } ]
To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.	[ { "ade": "rhabdomyolysis", "drug": "lovastatin" }, { "ade": "rhabdomyolysis", "drug": "clarithromycin" }, { "ade": "rhabdomyolysis", "drug": "azithromycin" } ]
A diagnosis of trastuzumab-induced pneumonitis was made.	[ { "ade": "pneumonitis", "drug": "trastuzumab" } ]
Marked elevation of serum creatine kinase associated with olanzapine therapy.	[ { "ade": "elevation of serum creatine kinase", "drug": "olanzapine" } ]
Quetiapine-induced myoclonus.	[ { "ade": "myoclonus", "drug": "Quetiapine" } ]
Although the data indicate an immune-complex cause for gold-salt nephropathy, the incident antigen (or antigens) and mechanism of action remain unidentified.	[ { "ade": "nephropathy", "drug": "gold-salt" } ]
OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock.	[ { "ade": "skin necrosis", "drug": "vasopressin" } ]
This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure.	[ { "ade": "respiratory failure", "drug": "vecuronium" } ]
CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.	[ { "ade": "Hypersensitivity reactions", "drug": "cyclosporine" }, { "ade": "Hypersensitivity reactions", "drug": "Cremophor EL" } ]
Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea.	[ { "ade": "Acute myeloid leukemia", "drug": "hydroxyurea" } ]
Ritonavir should be added to the list of drugs that can induce adverse cutaneous reactions in HIV patients.	[ { "ade": "adverse cutaneous reactions", "drug": "Ritonavir" } ]
Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure.	[ { "ade": "ARF", "drug": "Mannitol" } ]
While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.	[ { "ade": "renal failure", "drug": "dextran" } ]
The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.	[ { "ade": "subacute interstitial pneumonitis-related pulmonary fibrosis", "drug": "docetaxel" } ]
A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.	[ { "ade": "agranulocytosis", "drug": "propylthiouracil" } ]
BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.	[ { "ade": "collagenase activation", "drug": "Colchicine" }, { "ade": "adverse effect on wound healing", "drug": "Colchicine" } ]
DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse.	[ { "ade": "hyperlactatemia relapse", "drug": "zidovudine" } ]
In one child, a second course of carbamazepine resulted in a return of the dystonia.	[ { "ade": "dystonia", "drug": "carbamazepine" } ]
PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.	[ { "ade": "central nervous system depression", "drug": "brimonidine" } ]
Increased libido in a woman treated with fluvoxamine: a case report.	[ { "ade": "Increased libido", "drug": "fluvoxamine" } ]
Enalaprilat induced acute parotitis.	[ { "ade": "acute parotitis", "drug": "Enalaprilat" } ]
It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted.	[ { "ade": "nephrotic syndrome", "drug": "M-CSF" } ]
Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.	[ { "ade": "Pellagra encephalopathy", "drug": "isoniazid" } ]
We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy.	[ { "ade": "acute renal insufficiency", "drug": "ciprofloxacin" } ]
We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.	[ { "ade": "generalized cutaneous sclerosis", "drug": "diuron" }, { "ade": "generalized cutaneous sclerosis", "drug": "bromocil" }, { "ade": "generalized cutaneous sclerosis", "drug": "aminotriazole" } ]
Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report.	[ { "ade": "hemolytic uremic syndrome", "drug": "gemcitabine" } ]
Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication.	[ { "ade": "Acute eosinophilic pneumonia", "drug": "calcium stearate" } ]
Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril.	[ { "ade": "Neutropenia", "drug": "captopril" } ]
PURPOSE: To report a case of nodular scleritis following alendronate sodium.	[ { "ade": "nodular scleritis", "drug": "alendronate sodium" } ]
We report here a 26-year-old female with diffuse large B-cell lymphoma who died of severe pulmonary fibrosis 81 days after the administration of high-dose BCNU (600 mg/m2).	[ { "ade": "severe pulmonary fibrosis", "drug": "BCNU" } ]
Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient.	[ { "ade": "hepatotoxicity", "drug": "Trimethoprim-sulfamethoxazole" } ]
Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone.	[ { "ade": "mammary hyperplasias", "drug": "D-penicillamine" }, { "ade": "mammary hyperplasias", "drug": "Neothetazone" } ]
Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin.	[ { "ade": "Spontaneous hemothorax", "drug": "heparin" } ]
Ketanserin in the treatment of protamine-induced pulmonary hypertension.	[ { "ade": "pulmonary hypertension", "drug": "protamine" } ]
Mental nerve neuropathy as a result of hepatitis B vaccination.	[ { "ade": "Mental nerve neuropathy", "drug": "hepatitis B vaccination" } ]
Pulmonary fibrosis associated with nabumetone.	[ { "ade": "Pulmonary fibrosis", "drug": "nabumetone" } ]
Increasing the olanzapine dosage severely aggravated the symptoms of RLS.	[ { "ade": "RLS", "drug": "olanzapine" } ]
CONCLUSION: Gemcitabine-induced recall pneumonitis is a rarely reported phenomenon and should be taken into account even after extended time interval to the previous radiotherapy.	[ { "ade": "recall pneumonitis", "drug": "Gemcitabine" } ]
We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.	[ { "ade": "severe interstitial lung fibrosis", "drug": "busulfan" }, { "ade": "severe interstitial lung fibrosis", "drug": "melphalan" } ]
Patients should be informed about the risk of osteonecrosis when taking dexamethasone as an antiemetic drug.	[ { "ade": "osteonecrosis", "drug": "dexamethasone" } ]
Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine.	[ { "ade": "lupus erythematosus", "drug": "penicillamine" } ]
Leukaemoid monocytosis in M4 AML following chemotherapy and G-CSF.	[ { "ade": "Leukaemoid monocytosis", "drug": "G-CSF" } ]
CONCLUSIONS: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib.	[ { "ade": "colitis", "drug": "rofecoxib" } ]
We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking.	[ { "ade": "pericardial effusion", "drug": "gemcitabine" } ]
Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy.	[ { "ade": "agranulocytosis", "drug": "infliximab" } ]
A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported.	[ { "ade": "seizures", "drug": "lorazepam" } ]
We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function.	[ { "ade": "fatal fulminant hepatitis", "drug": "disulfiram" } ]
The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease.	[ { "ade": "daytime somnolence", "drug": "L-dopa" } ]
Currently the use of zidovudine is one of the few specific measures available, and as a potentially teratogenic and fetotoxic agent, any decision for its use requires evaluation of the potential for fetal damage.	[ { "ade": "teratogenic", "drug": "zidovudine" }, { "ade": "fetotoxic", "drug": "zidovudine" }, { "ade": "fetal damage", "drug": "zidovudine" } ]
Incomplete posterior hyaloid detachment after intravitreal pegaptanib injection in diabetic macular edema.	[ { "ade": "Incomplete posterior hyaloid detachment", "drug": "pegaptanib" } ]
Bromide intoxication secondary to pyridostigmine bromide therapy.	[ { "ade": "Bromide intoxication", "drug": "pyridostigmine bromide" } ]
We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.	[ { "ade": "spontaneous splenic infarction", "drug": "sumatriptan" } ]
The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.	[ { "ade": "multiple comedones", "drug": "imiquimod" }, { "ade": "ruptured epidermoid cysts", "drug": "imiquimod" } ]
Serotonin syndrome caused by interaction between citalopram and fentanyl.	[ { "ade": "Serotonin syndrome", "drug": "citalopram" }, { "ade": "Serotonin syndrome", "drug": "fentanyl" } ]
Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.	[ { "ade": "PPE", "drug": "cytarabine" } ]
Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed.	[ { "ade": "pulmonary oedema", "drug": "hexoprenaline" } ]
A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.	[ { "ade": "glycosuria", "drug": "halcinonide" }, { "ade": "postprandial hyperglycemia", "drug": "halcinonide" } ]
The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge.	[ { "ade": "renal deterioration", "drug": "cefuroxime" } ]
We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.	[ { "ade": "diphasic dyskinesias", "drug": "levo-dopa" } ]
The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient.	[ { "ade": "seizures", "drug": "amphotericin B" } ]
OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.	[ { "ade": "reproductive endocrine disorders", "drug": "valproate" } ]
Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment.	[ { "ade": "lactate elevation", "drug": "metronidazole" } ]
Used injudiciously, naloxone can lead to withdrawal syndrome, return of severe pain, and other adverse effects.	[ { "ade": "severe pain", "drug": "naloxone" }, { "ade": "withdrawal syndrome", "drug": "naloxone" } ]
Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation.	[ { "ade": "increased calcium-release", "drug": "dihydrotachysterol" } ]
We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine.	[ { "ade": "photo-onycholysis", "drug": "olanzapine" } ]
Based on the clinical status of the patient, it was suspected that several conditions contributed to the abnormal hypersensitivity to warfarin.	[ { "ade": "abnormal hypersensitivity", "drug": "warfarin" } ]
Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse.	[ { "ade": "Pulmonary leukostasis", "drug": "all-trans retinoic acid" } ]
Lithium-induced Creutzfeldt-Jakob syndrome.	[ { "ade": "Creutzfeldt-Jakob syndrome", "drug": "Lithium" } ]
A 48-year-old woman who was treated for thyrotoxicosis with methimazole developed agranulocytosis.	[ { "ade": "agranulocytosis", "drug": "methimazole" } ]
In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.	[ { "ade": "myopathy", "drug": "colchicine" } ]
Torsade de pointes represents a potential complication of chronic amiodarone therapy.	[ { "ade": "Torsade de pointes", "drug": "amiodarone" } ]
He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.	[ { "ade": "hypersensitivity reaction", "drug": "MTX" }, { "ade": "chest tightness", "drug": "MTX" }, { "ade": "diffuse urticaria", "drug": "MTX" }, { "ade": "facial swelling", "drug": "MTX" }, { "ade": "cough", "drug": "MTX" } ]
The treatment for acidosis and hyperkalaemia should be started as soon as RTA is diagnosed, and the dosage of FK506 should also be reduced if possible.	[ { "ade": "RTA", "drug": "FK506" } ]
Disulfiram-like reactions with newer cephalosporins: cefmenoxime.	[ { "ade": "Disulfiram-like reactions", "drug": "cefmenoxime" } ]
Baclofen withdrawal: a cause of prolonged fever in the intensive care unit.	[ { "ade": "fever", "drug": "Baclofen" } ]
Niacin causes a reversible toxic cystoid maculopathy that occurs in approximately 0.67% of patients taking high doses of the drug.	[ { "ade": "reversible toxic cystoid maculopathy", "drug": "Niacin" } ]
Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.	[ { "ade": "Comeoscleral perforation", "drug": "mitomycin C" } ]
The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.	[ { "ade": "coma", "drug": "5-FU" }, { "ade": "encephalopathy", "drug": "5-FU" }, { "ade": "neurologic symptoms", "drug": "5-FU" }, { "ade": "severe acute 5-FU reactions", "drug": "5-FU" } ]
We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.	[ { "ade": "AML", "drug": "fludarabine" }, { "ade": "lung cancer", "drug": "fludarabine" } ]
A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion.	[ { "ade": "proteinuria", "drug": "temsirolimus" } ]
Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days.	[ { "ade": "ileus", "drug": "acarbose" } ]
In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA).	[ { "ade": "squamous cell carcinoma", "drug": "psoralens" } ]
CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin.	[ { "ade": "DAT-positive hemolytic episode", "drug": "oxaliplatin" } ]
Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics?	[ { "ade": "Epstein-Barr virus-associated lymphoproliferative disorder", "drug": "methotrexate" }, { "ade": "Epstein-Barr virus-associated lymphoproliferative disorder", "drug": "rofecoxib" } ]
A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.	[ { "ade": "spinal cord lesion", "drug": "zolmitriptan" } ]
Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.	[ { "ade": "carcinoma of the corpus uteri", "drug": "tamoxifen" } ]
Pulmonary gold toxicity.	[ { "ade": "Pulmonary gold toxicity", "drug": "gold" } ]
We present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy.	[ { "ade": "leukoencephalopathy", "drug": "ara = C" }, { "ade": "leukoencephalopathy", "drug": "methotrexate" } ]
BACKGROUND: Hypersensitivity reactions to cyclosporine are rare.	[ { "ade": "Hypersensitivity reactions", "drug": "cyclosporine" } ]

A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside.

[ { "ade": "hyponatremia", "drug": "adenine arabinoside" }, { "ade": "syndrome of inappropriate antidiuretic hormone", "drug": "adenine arabinoside" } ]

We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.

[ { "ade": "hypoalbuminaemia", "drug": "insulin" }, { "ade": "hyperinsulinaemia", "drug": "insulin" }, { "ade": "anti-natriuresis", "drug": "insulin" }, { "ade": "increased vascular permeability", "drug": "insulin" }, { "ade": "insulin insensitivity", "drug": "insulin" } ]

Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features.

[ { "ade": "retroperitoneal fibrosis", "drug": "Methysergide" } ]

Pulmonary toxicity associated with erlotinib.

[ { "ade": "Pulmonary toxicity", "drug": "erlotinib" } ]

Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta.

[ { "ade": "inflammatory arthritis", "drug": "IFN-beta" } ]

Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram.

[ { "ade": "T wave inversion", "drug": "pirmenol" }, { "ade": "QT prolongation", "drug": "pirmenol" } ]

Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.

[ { "ade": "general erythema", "drug": "cisplatin" }, { "ade": "abdominal pain", "drug": "cisplatin" }, { "ade": "dyspnea", "drug": "cisplatin" }, { "ade": "fever", "drug": "cisplatin" }, { "ade": "hypotension", "drug": "cisplatin" }, { "ade": "hypersensitivity reactions", "drug": "cisplatin" } ]

OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.

[ { "ade": "lipoatrophy", "drug": "human insulin" } ]

Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia.

[ { "ade": "hypokalemia", "drug": "vinorelbine" }, { "ade": "SIADH", "drug": "vinorelbine" } ]

From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).

[ { "ade": "renal colic", "drug": "indinavir" }, { "ade": "fever", "drug": "indinavir" }, { "ade": "cutaneous rash", "drug": "nelfinavir" }, { "ade": "nausea", "drug": "efavirenz" }, { "ade": "temporary memory loss", "drug": "efavirenz" } ]

The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment.

[ { "ade": "DIC", "drug": "anti-D IGIV" } ]

Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms.

[ { "ade": "carcinogenic", "drug": "Tamoxifen" } ]

To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.

[ { "ade": "rhabdomyolysis", "drug": "lovastatin" }, { "ade": "rhabdomyolysis", "drug": "clarithromycin" }, { "ade": "rhabdomyolysis", "drug": "azithromycin" } ]

A diagnosis of trastuzumab-induced pneumonitis was made.

[ { "ade": "pneumonitis", "drug": "trastuzumab" } ]

Marked elevation of serum creatine kinase associated with olanzapine therapy.

[ { "ade": "elevation of serum creatine kinase", "drug": "olanzapine" } ]

Quetiapine-induced myoclonus.

[ { "ade": "myoclonus", "drug": "Quetiapine" } ]

Although the data indicate an immune-complex cause for gold-salt nephropathy, the incident antigen (or antigens) and mechanism of action remain unidentified.

[ { "ade": "nephropathy", "drug": "gold-salt" } ]

OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock.

[ { "ade": "skin necrosis", "drug": "vasopressin" } ]

This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure.

[ { "ade": "respiratory failure", "drug": "vecuronium" } ]

CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.

[ { "ade": "Hypersensitivity reactions", "drug": "cyclosporine" }, { "ade": "Hypersensitivity reactions", "drug": "Cremophor EL" } ]

Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea.

[ { "ade": "Acute myeloid leukemia", "drug": "hydroxyurea" } ]

Ritonavir should be added to the list of drugs that can induce adverse cutaneous reactions in HIV patients.

[ { "ade": "adverse cutaneous reactions", "drug": "Ritonavir" } ]

Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure.

[ { "ade": "ARF", "drug": "Mannitol" } ]

While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.

[ { "ade": "renal failure", "drug": "dextran" } ]

The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.

[ { "ade": "subacute interstitial pneumonitis-related pulmonary fibrosis", "drug": "docetaxel" } ]

A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.

[ { "ade": "agranulocytosis", "drug": "propylthiouracil" } ]

BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.

[ { "ade": "collagenase activation", "drug": "Colchicine" }, { "ade": "adverse effect on wound healing", "drug": "Colchicine" } ]

DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse.

[ { "ade": "hyperlactatemia relapse", "drug": "zidovudine" } ]

In one child, a second course of carbamazepine resulted in a return of the dystonia.

[ { "ade": "dystonia", "drug": "carbamazepine" } ]

PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.

[ { "ade": "central nervous system depression", "drug": "brimonidine" } ]

Increased libido in a woman treated with fluvoxamine: a case report.

[ { "ade": "Increased libido", "drug": "fluvoxamine" } ]

Enalaprilat induced acute parotitis.

[ { "ade": "acute parotitis", "drug": "Enalaprilat" } ]

It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted.

[ { "ade": "nephrotic syndrome", "drug": "M-CSF" } ]

Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.

[ { "ade": "Pellagra encephalopathy", "drug": "isoniazid" } ]

We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy.

[ { "ade": "acute renal insufficiency", "drug": "ciprofloxacin" } ]

We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.

[ { "ade": "generalized cutaneous sclerosis", "drug": "diuron" }, { "ade": "generalized cutaneous sclerosis", "drug": "bromocil" }, { "ade": "generalized cutaneous sclerosis", "drug": "aminotriazole" } ]

Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report.

[ { "ade": "hemolytic uremic syndrome", "drug": "gemcitabine" } ]

Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication.

[ { "ade": "Acute eosinophilic pneumonia", "drug": "calcium stearate" } ]

Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril.

[ { "ade": "Neutropenia", "drug": "captopril" } ]

PURPOSE: To report a case of nodular scleritis following alendronate sodium.

[ { "ade": "nodular scleritis", "drug": "alendronate sodium" } ]

We report here a 26-year-old female with diffuse large B-cell lymphoma who died of severe pulmonary fibrosis 81 days after the administration of high-dose BCNU (600 mg/m2).

[ { "ade": "severe pulmonary fibrosis", "drug": "BCNU" } ]

Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient.

[ { "ade": "hepatotoxicity", "drug": "Trimethoprim-sulfamethoxazole" } ]

Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone.

[ { "ade": "mammary hyperplasias", "drug": "D-penicillamine" }, { "ade": "mammary hyperplasias", "drug": "Neothetazone" } ]

Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin.

[ { "ade": "Spontaneous hemothorax", "drug": "heparin" } ]

Ketanserin in the treatment of protamine-induced pulmonary hypertension.

[ { "ade": "pulmonary hypertension", "drug": "protamine" } ]

Mental nerve neuropathy as a result of hepatitis B vaccination.

[ { "ade": "Mental nerve neuropathy", "drug": "hepatitis B vaccination" } ]

Pulmonary fibrosis associated with nabumetone.

[ { "ade": "Pulmonary fibrosis", "drug": "nabumetone" } ]

Increasing the olanzapine dosage severely aggravated the symptoms of RLS.

[ { "ade": "RLS", "drug": "olanzapine" } ]

CONCLUSION: Gemcitabine-induced recall pneumonitis is a rarely reported phenomenon and should be taken into account even after extended time interval to the previous radiotherapy.

[ { "ade": "recall pneumonitis", "drug": "Gemcitabine" } ]

We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.

[ { "ade": "severe interstitial lung fibrosis", "drug": "busulfan" }, { "ade": "severe interstitial lung fibrosis", "drug": "melphalan" } ]

Patients should be informed about the risk of osteonecrosis when taking dexamethasone as an antiemetic drug.

[ { "ade": "osteonecrosis", "drug": "dexamethasone" } ]

Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine.

[ { "ade": "lupus erythematosus", "drug": "penicillamine" } ]

Leukaemoid monocytosis in M4 AML following chemotherapy and G-CSF.

[ { "ade": "Leukaemoid monocytosis", "drug": "G-CSF" } ]

CONCLUSIONS: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib.

[ { "ade": "colitis", "drug": "rofecoxib" } ]

We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking.

[ { "ade": "pericardial effusion", "drug": "gemcitabine" } ]

Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy.

[ { "ade": "agranulocytosis", "drug": "infliximab" } ]

A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported.

[ { "ade": "seizures", "drug": "lorazepam" } ]

We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function.

[ { "ade": "fatal fulminant hepatitis", "drug": "disulfiram" } ]

The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease.

[ { "ade": "daytime somnolence", "drug": "L-dopa" } ]

Currently the use of zidovudine is one of the few specific measures available, and as a potentially teratogenic and fetotoxic agent, any decision for its use requires evaluation of the potential for fetal damage.

[ { "ade": "teratogenic", "drug": "zidovudine" }, { "ade": "fetotoxic", "drug": "zidovudine" }, { "ade": "fetal damage", "drug": "zidovudine" } ]

Incomplete posterior hyaloid detachment after intravitreal pegaptanib injection in diabetic macular edema.

[ { "ade": "Incomplete posterior hyaloid detachment", "drug": "pegaptanib" } ]

Bromide intoxication secondary to pyridostigmine bromide therapy.

[ { "ade": "Bromide intoxication", "drug": "pyridostigmine bromide" } ]

We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.

[ { "ade": "spontaneous splenic infarction", "drug": "sumatriptan" } ]

The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.

[ { "ade": "multiple comedones", "drug": "imiquimod" }, { "ade": "ruptured epidermoid cysts", "drug": "imiquimod" } ]

Serotonin syndrome caused by interaction between citalopram and fentanyl.

[ { "ade": "Serotonin syndrome", "drug": "citalopram" }, { "ade": "Serotonin syndrome", "drug": "fentanyl" } ]

Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.

[ { "ade": "PPE", "drug": "cytarabine" } ]

Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed.

[ { "ade": "pulmonary oedema", "drug": "hexoprenaline" } ]

A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.

[ { "ade": "glycosuria", "drug": "halcinonide" }, { "ade": "postprandial hyperglycemia", "drug": "halcinonide" } ]

The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge.

[ { "ade": "renal deterioration", "drug": "cefuroxime" } ]

We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.

[ { "ade": "diphasic dyskinesias", "drug": "levo-dopa" } ]

The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient.

[ { "ade": "seizures", "drug": "amphotericin B" } ]

OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.

[ { "ade": "reproductive endocrine disorders", "drug": "valproate" } ]

Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment.

[ { "ade": "lactate elevation", "drug": "metronidazole" } ]

Used injudiciously, naloxone can lead to withdrawal syndrome, return of severe pain, and other adverse effects.

[ { "ade": "severe pain", "drug": "naloxone" }, { "ade": "withdrawal syndrome", "drug": "naloxone" } ]

Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation.

[ { "ade": "increased calcium-release", "drug": "dihydrotachysterol" } ]

We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine.

[ { "ade": "photo-onycholysis", "drug": "olanzapine" } ]

Based on the clinical status of the patient, it was suspected that several conditions contributed to the abnormal hypersensitivity to warfarin.

[ { "ade": "abnormal hypersensitivity", "drug": "warfarin" } ]

Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse.

[ { "ade": "Pulmonary leukostasis", "drug": "all-trans retinoic acid" } ]

Lithium-induced Creutzfeldt-Jakob syndrome.

[ { "ade": "Creutzfeldt-Jakob syndrome", "drug": "Lithium" } ]

A 48-year-old woman who was treated for thyrotoxicosis with methimazole developed agranulocytosis.

[ { "ade": "agranulocytosis", "drug": "methimazole" } ]

In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.

[ { "ade": "myopathy", "drug": "colchicine" } ]

Torsade de pointes represents a potential complication of chronic amiodarone therapy.

[ { "ade": "Torsade de pointes", "drug": "amiodarone" } ]

He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.

[ { "ade": "hypersensitivity reaction", "drug": "MTX" }, { "ade": "chest tightness", "drug": "MTX" }, { "ade": "diffuse urticaria", "drug": "MTX" }, { "ade": "facial swelling", "drug": "MTX" }, { "ade": "cough", "drug": "MTX" } ]

The treatment for acidosis and hyperkalaemia should be started as soon as RTA is diagnosed, and the dosage of FK506 should also be reduced if possible.

[ { "ade": "RTA", "drug": "FK506" } ]

Disulfiram-like reactions with newer cephalosporins: cefmenoxime.

[ { "ade": "Disulfiram-like reactions", "drug": "cefmenoxime" } ]

Baclofen withdrawal: a cause of prolonged fever in the intensive care unit.

[ { "ade": "fever", "drug": "Baclofen" } ]

Niacin causes a reversible toxic cystoid maculopathy that occurs in approximately 0.67% of patients taking high doses of the drug.

[ { "ade": "reversible toxic cystoid maculopathy", "drug": "Niacin" } ]

Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.

[ { "ade": "Comeoscleral perforation", "drug": "mitomycin C" } ]

The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.

[ { "ade": "coma", "drug": "5-FU" }, { "ade": "encephalopathy", "drug": "5-FU" }, { "ade": "neurologic symptoms", "drug": "5-FU" }, { "ade": "severe acute 5-FU reactions", "drug": "5-FU" } ]

We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.

[ { "ade": "AML", "drug": "fludarabine" }, { "ade": "lung cancer", "drug": "fludarabine" } ]

A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion.

[ { "ade": "proteinuria", "drug": "temsirolimus" } ]

Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days.

[ { "ade": "ileus", "drug": "acarbose" } ]

In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA).

[ { "ade": "squamous cell carcinoma", "drug": "psoralens" } ]

CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin.

[ { "ade": "DAT-positive hemolytic episode", "drug": "oxaliplatin" } ]

Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics?

[ { "ade": "Epstein-Barr virus-associated lymphoproliferative disorder", "drug": "methotrexate" }, { "ade": "Epstein-Barr virus-associated lymphoproliferative disorder", "drug": "rofecoxib" } ]

A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.

[ { "ade": "spinal cord lesion", "drug": "zolmitriptan" } ]

Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.

[ { "ade": "carcinoma of the corpus uteri", "drug": "tamoxifen" } ]

Pulmonary gold toxicity.

[ { "ade": "Pulmonary gold toxicity", "drug": "gold" } ]

We present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy.

[ { "ade": "leukoencephalopathy", "drug": "ara = C" }, { "ade": "leukoencephalopathy", "drug": "methotrexate" } ]

BACKGROUND: Hypersensitivity reactions to cyclosporine are rare.

[ { "ade": "Hypersensitivity reactions", "drug": "cyclosporine" } ]