mihirhirave/entity_extraction_ade_v2_with_validation

text stringlengths 22 455	relations listlengths 1 24
Norethisterone in these 69 pregnancies accounted for 33.3% (5 of 15) cases of clitoral hypertrophy diagnosed in 100,756 consecutive births.	[ { "ade": "clitoral hypertrophy", "drug": "Norethisterone" } ]
Ten to 15% of patients treated with ifosfamide develop an encephalopathy.	[ { "ade": "encephalopathy", "drug": "ifosfamide" } ]
OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.	[ { "ade": "nonconvulsive status epilepticus", "drug": "ifosfamide" }, { "ade": "NCSE", "drug": "ifosfamide" } ]
Probable propafenone-induced transient global amnesia.	[ { "ade": "transient global amnesia", "drug": "propafenone" } ]
A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment.	[ { "ade": "CNS lymphoma", "drug": "MM" } ]
Flare of Kaposi's sarcoma (KS) is well described in immunosuppressed patients treated with corticosteroids and rituximab, but has not yet been reported during treatment with imatinib.	[ { "ade": "KS", "drug": "rituximab" }, { "ade": "Kaposi's sarcoma", "drug": "rituximab" } ]
Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).	[ { "ade": "neutropenia", "drug": "gold" } ]
Reversible nonthrombocytopenic palpable purpura associated with metoclopramide.	[ { "ade": "nonthrombocytopenic palpable purpura", "drug": "metoclopramide" } ]
This report describes a case of neuroleptic malignant syndrome due to risperidone in a child with Joubert syndrome.	[ { "ade": "neuroleptic malignant syndrome", "drug": "risperidone" } ]
These novel findings may offer specific therapeutic targets in the treatment of BCNU-associated pulmonary fibrosis.	[ { "ade": "pulmonary fibrosis", "drug": "BCNU" } ]
We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.	[ { "ade": "anaphylaxis", "drug": "metaraminol" } ]
METHODS: Three patients with apparent itraconazole-induced liver injury were studied.	[ { "ade": "liver injury", "drug": "itraconazole" } ]
Amifostine-induced fever: case report and review of the literature.	[ { "ade": "fever", "drug": "Amifostine" } ]
To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.	[ { "ade": "massive plasmocytosis", "drug": "MMI" }, { "ade": "pancytopenia", "drug": "MMI" } ]
BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.	[ { "ade": "Ovarian cancer", "drug": "tamoxifen" } ]
CONCLUSIONS: Colchicine-induced myopathy should be excluded in patients with FMF who present with generalized muscle weakness.	[ { "ade": "myopathy", "drug": "Colchicine" } ]
Prazosin-induced first-dose phenomenon possibly associated with hemorrhagic stroke: a report of three cases.	[ { "ade": "hemorrhagic stroke", "drug": "Prazosin" } ]
ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.	[ { "ade": "ARDS", "drug": "rituximab" }, { "ade": "severe pulmonary symptoms", "drug": "rituximab" } ]
Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.	[ { "ade": "Thrombotic thrombocytopenic purpura", "drug": "penicillamine" } ]
These findings suggest that the corneal and retinal changes are the result of a toxic effect of tamoxifen when used in the doses and duration described.	[ { "ade": "corneal and retinal changes", "drug": "tamoxifen" } ]
Physicians treating patients with methotrexate for juvenile rheumatoid arthritis must be aware of this extraarticular side effect.	[ { "ade": "extraarticular side effect", "drug": "methotrexate" } ]
The authors report two cases of acute dystonic reactions (ADRs) as a side effect of lamivudine.	[ { "ade": "acute dystonic reactions", "drug": "lamivudine" }, { "ade": "ADRs", "drug": "lamivudine" } ]
A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.	[ { "ade": "restless legs symptoms", "drug": "IFN alpha" }, { "ade": "restless legs symptoms", "drug": "interferon-alpha" } ]
When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction, close attention must be paid to avoid life-threatening arrhythmias due to high plasma concentrations of the drug.	[ { "ade": "life-threatening arrhythmias", "drug": "pilsicainide" } ]
This pattern is suggestive of renal toxicity due to tobramycin.	[ { "ade": "renal toxicity", "drug": "tobramycin" } ]
This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.	[ { "ade": "severe illness", "drug": "minocycline" }, { "ade": "massive cytokine release", "drug": "minocycline" }, { "ade": "lymphocyte over-activation", "drug": "minocycline" } ]
Multiple seizures after bupropion overdose in a small child.	[ { "ade": "Multiple seizures", "drug": "bupropion" } ]
Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.	[ { "ade": "gastrointestinal adverse reactions", "drug": "Ibuprofen" } ]
After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.	[ { "ade": "desmethylclomipramine plasma level increase", "drug": "citalopram" }, { "ade": "8-hydroacy-desmethylclomipramine plasma level decrease", "drug": "citalopram" } ]
Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.	[ { "ade": "HUS", "drug": "MMC" }, { "ade": "Pulmonary hemorrhage", "drug": "MMC" } ]
In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.	[ { "ade": "CIPS", "drug": "cyclosporine" } ]
All patients had taken phenytoin for variable time periods (range 16-80 days; mean: 40) and were on the medication when the skin lesions first appeared.	[ { "ade": "skin lesions", "drug": "phenytoin" } ]
The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.	[ { "ade": "anaphylactoid reaction", "drug": "zomepirac" } ]
Combining methylephedrine and Chinese herbal drugs might carry a risk of stroke.	[ { "ade": "stroke", "drug": "methylephedrine" } ]
Cutaneous eruptions occur in 3% of individuals administered carbamazepine.	[ { "ade": "Cutaneous eruptions", "drug": "carbamazepine" } ]
Such a rapid and relentless progression of methyldopa-induced liver injury is undoubtedly rare, but it may be prevented by careful supervision of patients who exhibit liver function abnormalities early in the course of therapy.	[ { "ade": "liver injury", "drug": "methyldopa" } ]
During the first treatment, dysarthria and ataxia were seen after completion of the patient's eighth and final dose of HDARAC.	[ { "ade": "ataxia", "drug": "HDARAC" }, { "ade": "dysarthria", "drug": "HDARAC" } ]
CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.	[ { "ade": "reproductive endocrine disorders", "drug": "valproate" } ]
Tremor: a newly described adverse event with long-term itraconazole therapy.	[ { "ade": "Tremor", "drug": "itraconazole" } ]
Temsirolimus-induced glomerulopathy.	[ { "ade": "glomerulopathy", "drug": "Temsirolimus" } ]
Thrombocytosis associated with enoxaparin: A very rare cause in newborns.	[ { "ade": "Thrombocytosis", "drug": "enoxaparin" } ]
In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence.	[ { "ade": "incontinence", "drug": "lithium carbonate" } ]
Transient leucopenia and thrombocytopenia associated with sodium nitroprusside infusion.	[ { "ade": "leucopenia", "drug": "sodium nitroprusside" }, { "ade": "thrombocytopenia", "drug": "sodium nitroprusside" } ]
Transtubular potassium gradient (TTKG) also decreased and an inverse correlation was found between TTKG and doses of phosphate (r = -0.37; p < 0.02; N = 38).	[ { "ade": "Transtubular potassium gradient (TTKG) also decreased", "drug": "phosphate" } ]
Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.	[ { "ade": "hepatitis", "drug": "propylthiouracil" }, { "ade": "eosinophilia", "drug": "propylthiouracil" }, { "ade": "skin reaction", "drug": "propylthiouracil" }, { "ade": "granulocytopenia", "drug": "propylthiouracil" }, { "ade": "lymphocyte sensitization", "drug": "propylthiouracil" } ]
We describe 3 elderly patients with moderate to severe ataxia that occurred while they were taking propafenone.	[ { "ade": "ataxia", "drug": "propafenone" } ]
DISCUSSION: To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept.	[ { "ade": "tuberculous uveitis", "drug": "etanercept" } ]
Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol.	[ { "ade": "Alternating sinus rhythm", "drug": "propranolol" }, { "ade": "intermittent sinoatrial block", "drug": "propranolol" } ]
We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment.	[ { "ade": "acute bilateral parotitis", "drug": "enalaprilat" } ]
Extra caution should be taken in using octreotide or its long-acting analog in patients otherwise predisposed to intrahepatic bile stasis.	[ { "ade": "intrahepatic bile stasis", "drug": "octreotide" } ]
ADR induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs; however, there have been no reports of lamivudine-induced ADR in the English literature.	[ { "ade": "ADR", "drug": "lamivudine" } ]
Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.	[ { "ade": "flare-up", "drug": "goserelin acetate" }, { "ade": "worsening pleuritis carcinomatosa", "drug": "goserelin acetate" }, { "ade": "severe dyspnea", "drug": "goserelin acetate" } ]
We report a case of severe respiratory failure due to gold salt toxicity in a patient suffering from rheumatoid arthritis requiring mechanical ventilation.	[ { "ade": "respiratory failure", "drug": "gold" } ]
RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.	[ { "ade": "cutaneous fragility", "drug": "oxaprozin" }, { "ade": "cutaneous fragility", "drug": "naproxen" }, { "ade": "tense bullae", "drug": "naproxen" }, { "ade": "tense bullae", "drug": "oxaprozin" } ]
Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.	[ { "ade": "hypophosphatemic osteomalacia", "drug": "sucralfate" } ]
A lupus-like syndrome associated with infliximab therapy.	[ { "ade": "lupus-like syndrome", "drug": "infliximab" } ]
A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.	[ { "ade": "irreversible lethal renal failure", "drug": "ifosfamide" }, { "ade": "anuria", "drug": "ifosfamide" } ]
An encephalopathy and cardiomyopathy developed in a seventeen-year-old girl with chemotherapy-induced renal failure while receiving an intravesical aluminum infusion for hemorrhagic cystitis.	[ { "ade": "encephalopathy", "drug": "aluminum" }, { "ade": "cardiomyopathy", "drug": "aluminum" } ]
Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment.	[ { "ade": "autoimmune thyroiditis", "drug": "IFN-alpha" }, { "ade": "thyroid disorders", "drug": "IFN-alpha" } ]
We describe the clinical response, as determined by increases in total Hb and decreased transfusion needs, in five patients with thalassemia intermedia treated with HU alone or in combination with SPB.	[ { "ade": "increases in total Hb", "drug": "SPB" }, { "ade": "increases in total Hb", "drug": "HU" } ]
We describe a case of infection with Mycobacterium abscessus in a 67-year-old woman receiving infliximab as a component of her therapy for RA.	[ { "ade": "Mycobacterium abscessus", "drug": "infliximab" } ]
Retinoic acid may increase the risk of bone marrow transplant nephropathy.	[ { "ade": "bone marrow transplant nephropathy", "drug": "Retinoic acid" } ]
Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.	[ { "ade": "Hepatic angiosarcoma", "drug": "cyclophosphamide" } ]
To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.	[ { "ade": "TTP", "drug": "penicillamine" } ]
It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.	[ { "ade": "sulphasalazine syndrome", "drug": "sulphasalazine" }, { "ade": "fatal", "drug": "sulphasalazine" }, { "ade": "immunoallergic reaction", "drug": "sulphasalazine" } ]
Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.	[ { "ade": "bilateral optic neuritis", "drug": "recombinant interferon alpha-2b" }, { "ade": "bowel and bladder dysfunction", "drug": "recombinant interferon alpha-2b" }, { "ade": "numbness of the lower extremities", "drug": "recombinant interferon alpha-2b" } ]
Focal renal cortical necrosis associated with zomepirac.	[ { "ade": "Focal renal cortical necrosis", "drug": "zomepirac" } ]
She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.	[ { "ade": "severe urticarial rash", "drug": "Enoxaparin" } ]
Clofazimine induced nail changes.	[ { "ade": "nail changes", "drug": "Clofazimine" } ]
A 53-year-old man developed NMS without rigidity while taking olanzapine.	[ { "ade": "NMS", "drug": "olanzapine" } ]
Generalized argyria after habitual use of AgNO3.	[ { "ade": "Generalized argyria", "drug": "AgNO3" } ]
He was started on oral lansoprazole 60 mg twice daily and, on hospital day 2, his platelet count decreased to 102 x 10(3)/mm(3); on hospital day 3, the platelet count was 36 x 10(3)/mm(3).	[ { "ade": "platelet count decreased", "drug": "lansoprazole" } ]
Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses.	[ { "ade": "RS", "drug": "aspirin" } ]
Sustained monomorphic ventricular tachycardia after adenosine infusion.	[ { "ade": "Sustained monomorphic ventricular tachycardia", "drug": "adenosine" } ]
Sensorimotor polyneuropathy with 5-aminosalicylic acid: a case report.	[ { "ade": "Sensorimotor polyneuropathy", "drug": "5-aminosalicylic acid" } ]
Linear immunoglobulin A bullous dermatosis induced by gemcitabine.	[ { "ade": "Linear immunoglobulin A bullous dermatosis", "drug": "gemcitabine" } ]
Sustained ventricular tachycardia in a thalidomide-treated patient with primary plasma-cell leukemia.	[ { "ade": "Sustained ventricular tachycardia", "drug": "thalidomide" } ]
In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine.	[ { "ade": "inhibition of hematopoiesis", "drug": "D-penicillamine" } ]
A case of pyridoxine-dependent seizures is reported.	[ { "ade": "seizures", "drug": "pyridoxine" } ]
This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.	[ { "ade": "acute interstitial pneumonitis", "drug": "hydroxyurea" } ]
Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.	[ { "ade": "hyperthyroidism", "drug": "IFN-alpha" } ]
We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.	[ { "ade": "fever", "drug": "epoprostenol" }, { "ade": "scaling", "drug": "epoprostenol" }, { "ade": "vomiting", "drug": "epoprostenol" }, { "ade": "rapidly progressive erythema", "drug": "epoprostenol" }, { "ade": "nausea", "drug": "epoprostenol" } ]
The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.	[ { "ade": "hypotension", "drug": "verapamil" } ]
OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.	[ { "ade": "NMS", "drug": "fluphenazine" }, { "ade": "neuroleptic malignant syndrome", "drug": "fluphenazine" } ]
Dipyrone-induced granulocytopenia: a case for awareness.	[ { "ade": "granulocytopenia", "drug": "Dipyrone" } ]
Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.	[ { "ade": "Imidazoline intoxication", "drug": "Imidazoline" } ]
A patient with severe cholestatic jaundice induced by captopril is presented.	[ { "ade": "severe cholestatic jaundice", "drug": "captopril" } ]
However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable.	[ { "ade": "liver injury", "drug": "troglitazone" } ]
Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.	[ { "ade": "SLE", "drug": "carbamazepine" } ]
A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.	[ { "ade": "B-cell lymphoma", "drug": "razoxane" } ]
We report a case of a patient with rheumatoid arthritis treated with low-dose methotrexate (15 mg/week) who developed infection with both M. tuberculosis and M. chelonae after the revision of a prosthetic hip.	[ { "ade": "infection with both M. tuberculosis and M. chelonae", "drug": "methotrexate" } ]
Erosion of psoriatic plaques: an early sign of methotrexate toxicity.	[ { "ade": "Erosion of psoriatic plaques", "drug": "methotrexate" }, { "ade": "methotrexate toxicity", "drug": "methotrexate" } ]
The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.	[ { "ade": "fungal infections", "drug": "alemtuzumab" }, { "ade": "opportunistic infections", "drug": "alemtuzumab" } ]
The literature of vincristine optic nerve toxicity is reviewed.	[ { "ade": "optic nerve toxicity", "drug": "vincristine" } ]
Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.	[ { "ade": "LABD", "drug": "Vancomycin" } ]
OBJECTIVE: To report a case of toxin-positive Clostridium difficile-induced colitis (CDIC) after use of clindamycin phosphate vaginal cream.	[ { "ade": "toxin-positive Clostridium difficile-induced colitis", "drug": "clindamycin phosphate" } ]
This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.	[ { "ade": "bilateral avascular necrosis of the femoral heads", "drug": "dexamethasone" } ]
Penicillin-induced Jarisch-Herxheimer reaction.	[ { "ade": "Jarisch-Herxheimer reaction", "drug": "Penicillin" } ]
CASE SUMMARY: A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness) presented with JHR after an initial intravenous dose of penicillin G for presumed neurosyphilis.	[ { "ade": "JHR", "drug": "penicillin G" } ]
Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.	[ { "ade": "renal tubular dysfunction", "drug": "sulfamethoxazole-trimethoprim" }, { "ade": "Hyperkalaemia", "drug": "sulfamethoxazole-trimethoprim" } ]

Norethisterone in these 69 pregnancies accounted for 33.3% (5 of 15) cases of clitoral hypertrophy diagnosed in 100,756 consecutive births.

[ { "ade": "clitoral hypertrophy", "drug": "Norethisterone" } ]

Ten to 15% of patients treated with ifosfamide develop an encephalopathy.

[ { "ade": "encephalopathy", "drug": "ifosfamide" } ]

OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.

[ { "ade": "nonconvulsive status epilepticus", "drug": "ifosfamide" }, { "ade": "NCSE", "drug": "ifosfamide" } ]

Probable propafenone-induced transient global amnesia.

[ { "ade": "transient global amnesia", "drug": "propafenone" } ]

A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment.

[ { "ade": "CNS lymphoma", "drug": "MM" } ]

Flare of Kaposi's sarcoma (KS) is well described in immunosuppressed patients treated with corticosteroids and rituximab, but has not yet been reported during treatment with imatinib.

[ { "ade": "KS", "drug": "rituximab" }, { "ade": "Kaposi's sarcoma", "drug": "rituximab" } ]

Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).

[ { "ade": "neutropenia", "drug": "gold" } ]

Reversible nonthrombocytopenic palpable purpura associated with metoclopramide.

[ { "ade": "nonthrombocytopenic palpable purpura", "drug": "metoclopramide" } ]

This report describes a case of neuroleptic malignant syndrome due to risperidone in a child with Joubert syndrome.

[ { "ade": "neuroleptic malignant syndrome", "drug": "risperidone" } ]

These novel findings may offer specific therapeutic targets in the treatment of BCNU-associated pulmonary fibrosis.

[ { "ade": "pulmonary fibrosis", "drug": "BCNU" } ]

We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.

[ { "ade": "anaphylaxis", "drug": "metaraminol" } ]

METHODS: Three patients with apparent itraconazole-induced liver injury were studied.

[ { "ade": "liver injury", "drug": "itraconazole" } ]

Amifostine-induced fever: case report and review of the literature.

[ { "ade": "fever", "drug": "Amifostine" } ]

To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.

[ { "ade": "massive plasmocytosis", "drug": "MMI" }, { "ade": "pancytopenia", "drug": "MMI" } ]

BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.

[ { "ade": "Ovarian cancer", "drug": "tamoxifen" } ]

CONCLUSIONS: Colchicine-induced myopathy should be excluded in patients with FMF who present with generalized muscle weakness.

[ { "ade": "myopathy", "drug": "Colchicine" } ]

Prazosin-induced first-dose phenomenon possibly associated with hemorrhagic stroke: a report of three cases.

[ { "ade": "hemorrhagic stroke", "drug": "Prazosin" } ]

ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.

[ { "ade": "ARDS", "drug": "rituximab" }, { "ade": "severe pulmonary symptoms", "drug": "rituximab" } ]

Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.

[ { "ade": "Thrombotic thrombocytopenic purpura", "drug": "penicillamine" } ]

These findings suggest that the corneal and retinal changes are the result of a toxic effect of tamoxifen when used in the doses and duration described.

[ { "ade": "corneal and retinal changes", "drug": "tamoxifen" } ]

Physicians treating patients with methotrexate for juvenile rheumatoid arthritis must be aware of this extraarticular side effect.

[ { "ade": "extraarticular side effect", "drug": "methotrexate" } ]

The authors report two cases of acute dystonic reactions (ADRs) as a side effect of lamivudine.

[ { "ade": "acute dystonic reactions", "drug": "lamivudine" }, { "ade": "ADRs", "drug": "lamivudine" } ]

A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.

[ { "ade": "restless legs symptoms", "drug": "IFN alpha" }, { "ade": "restless legs symptoms", "drug": "interferon-alpha" } ]

When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction, close attention must be paid to avoid life-threatening arrhythmias due to high plasma concentrations of the drug.

[ { "ade": "life-threatening arrhythmias", "drug": "pilsicainide" } ]

This pattern is suggestive of renal toxicity due to tobramycin.

[ { "ade": "renal toxicity", "drug": "tobramycin" } ]

This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.

[ { "ade": "severe illness", "drug": "minocycline" }, { "ade": "massive cytokine release", "drug": "minocycline" }, { "ade": "lymphocyte over-activation", "drug": "minocycline" } ]

Multiple seizures after bupropion overdose in a small child.

[ { "ade": "Multiple seizures", "drug": "bupropion" } ]

Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.

[ { "ade": "gastrointestinal adverse reactions", "drug": "Ibuprofen" } ]

After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.

[ { "ade": "desmethylclomipramine plasma level increase", "drug": "citalopram" }, { "ade": "8-hydroacy-desmethylclomipramine plasma level decrease", "drug": "citalopram" } ]

Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.

[ { "ade": "HUS", "drug": "MMC" }, { "ade": "Pulmonary hemorrhage", "drug": "MMC" } ]

In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.

[ { "ade": "CIPS", "drug": "cyclosporine" } ]

All patients had taken phenytoin for variable time periods (range 16-80 days; mean: 40) and were on the medication when the skin lesions first appeared.

[ { "ade": "skin lesions", "drug": "phenytoin" } ]

The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.

[ { "ade": "anaphylactoid reaction", "drug": "zomepirac" } ]

Combining methylephedrine and Chinese herbal drugs might carry a risk of stroke.

[ { "ade": "stroke", "drug": "methylephedrine" } ]

Cutaneous eruptions occur in 3% of individuals administered carbamazepine.

[ { "ade": "Cutaneous eruptions", "drug": "carbamazepine" } ]

Such a rapid and relentless progression of methyldopa-induced liver injury is undoubtedly rare, but it may be prevented by careful supervision of patients who exhibit liver function abnormalities early in the course of therapy.

[ { "ade": "liver injury", "drug": "methyldopa" } ]

During the first treatment, dysarthria and ataxia were seen after completion of the patient's eighth and final dose of HDARAC.

[ { "ade": "ataxia", "drug": "HDARAC" }, { "ade": "dysarthria", "drug": "HDARAC" } ]

CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.

[ { "ade": "reproductive endocrine disorders", "drug": "valproate" } ]

Tremor: a newly described adverse event with long-term itraconazole therapy.

[ { "ade": "Tremor", "drug": "itraconazole" } ]

Temsirolimus-induced glomerulopathy.

[ { "ade": "glomerulopathy", "drug": "Temsirolimus" } ]

Thrombocytosis associated with enoxaparin: A very rare cause in newborns.

[ { "ade": "Thrombocytosis", "drug": "enoxaparin" } ]

In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence.

[ { "ade": "incontinence", "drug": "lithium carbonate" } ]

Transient leucopenia and thrombocytopenia associated with sodium nitroprusside infusion.

[ { "ade": "leucopenia", "drug": "sodium nitroprusside" }, { "ade": "thrombocytopenia", "drug": "sodium nitroprusside" } ]

Transtubular potassium gradient (TTKG) also decreased and an inverse correlation was found between TTKG and doses of phosphate (r = -0.37; p < 0.02; N = 38).

[ { "ade": "Transtubular potassium gradient (TTKG) also decreased", "drug": "phosphate" } ]

Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.

[ { "ade": "hepatitis", "drug": "propylthiouracil" }, { "ade": "eosinophilia", "drug": "propylthiouracil" }, { "ade": "skin reaction", "drug": "propylthiouracil" }, { "ade": "granulocytopenia", "drug": "propylthiouracil" }, { "ade": "lymphocyte sensitization", "drug": "propylthiouracil" } ]

We describe 3 elderly patients with moderate to severe ataxia that occurred while they were taking propafenone.

[ { "ade": "ataxia", "drug": "propafenone" } ]

DISCUSSION: To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept.

[ { "ade": "tuberculous uveitis", "drug": "etanercept" } ]

Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol.

[ { "ade": "Alternating sinus rhythm", "drug": "propranolol" }, { "ade": "intermittent sinoatrial block", "drug": "propranolol" } ]

We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment.

[ { "ade": "acute bilateral parotitis", "drug": "enalaprilat" } ]

Extra caution should be taken in using octreotide or its long-acting analog in patients otherwise predisposed to intrahepatic bile stasis.

[ { "ade": "intrahepatic bile stasis", "drug": "octreotide" } ]

ADR induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs; however, there have been no reports of lamivudine-induced ADR in the English literature.

[ { "ade": "ADR", "drug": "lamivudine" } ]

Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.

[ { "ade": "flare-up", "drug": "goserelin acetate" }, { "ade": "worsening pleuritis carcinomatosa", "drug": "goserelin acetate" }, { "ade": "severe dyspnea", "drug": "goserelin acetate" } ]

We report a case of severe respiratory failure due to gold salt toxicity in a patient suffering from rheumatoid arthritis requiring mechanical ventilation.

[ { "ade": "respiratory failure", "drug": "gold" } ]

RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.

[ { "ade": "cutaneous fragility", "drug": "oxaprozin" }, { "ade": "cutaneous fragility", "drug": "naproxen" }, { "ade": "tense bullae", "drug": "naproxen" }, { "ade": "tense bullae", "drug": "oxaprozin" } ]

Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.

[ { "ade": "hypophosphatemic osteomalacia", "drug": "sucralfate" } ]

A lupus-like syndrome associated with infliximab therapy.

[ { "ade": "lupus-like syndrome", "drug": "infliximab" } ]

A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.

[ { "ade": "irreversible lethal renal failure", "drug": "ifosfamide" }, { "ade": "anuria", "drug": "ifosfamide" } ]

An encephalopathy and cardiomyopathy developed in a seventeen-year-old girl with chemotherapy-induced renal failure while receiving an intravesical aluminum infusion for hemorrhagic cystitis.

[ { "ade": "encephalopathy", "drug": "aluminum" }, { "ade": "cardiomyopathy", "drug": "aluminum" } ]

Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment.

[ { "ade": "autoimmune thyroiditis", "drug": "IFN-alpha" }, { "ade": "thyroid disorders", "drug": "IFN-alpha" } ]

We describe the clinical response, as determined by increases in total Hb and decreased transfusion needs, in five patients with thalassemia intermedia treated with HU alone or in combination with SPB.

[ { "ade": "increases in total Hb", "drug": "SPB" }, { "ade": "increases in total Hb", "drug": "HU" } ]

We describe a case of infection with Mycobacterium abscessus in a 67-year-old woman receiving infliximab as a component of her therapy for RA.

[ { "ade": "Mycobacterium abscessus", "drug": "infliximab" } ]

Retinoic acid may increase the risk of bone marrow transplant nephropathy.

[ { "ade": "bone marrow transplant nephropathy", "drug": "Retinoic acid" } ]

Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.

[ { "ade": "Hepatic angiosarcoma", "drug": "cyclophosphamide" } ]

To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.

[ { "ade": "TTP", "drug": "penicillamine" } ]

It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.

[ { "ade": "sulphasalazine syndrome", "drug": "sulphasalazine" }, { "ade": "fatal", "drug": "sulphasalazine" }, { "ade": "immunoallergic reaction", "drug": "sulphasalazine" } ]

Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.

[ { "ade": "bilateral optic neuritis", "drug": "recombinant interferon alpha-2b" }, { "ade": "bowel and bladder dysfunction", "drug": "recombinant interferon alpha-2b" }, { "ade": "numbness of the lower extremities", "drug": "recombinant interferon alpha-2b" } ]

Focal renal cortical necrosis associated with zomepirac.

[ { "ade": "Focal renal cortical necrosis", "drug": "zomepirac" } ]

She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.

[ { "ade": "severe urticarial rash", "drug": "Enoxaparin" } ]

Clofazimine induced nail changes.

[ { "ade": "nail changes", "drug": "Clofazimine" } ]

A 53-year-old man developed NMS without rigidity while taking olanzapine.

[ { "ade": "NMS", "drug": "olanzapine" } ]

Generalized argyria after habitual use of AgNO3.

[ { "ade": "Generalized argyria", "drug": "AgNO3" } ]

He was started on oral lansoprazole 60 mg twice daily and, on hospital day 2, his platelet count decreased to 102 x 10(3)/mm(3); on hospital day 3, the platelet count was 36 x 10(3)/mm(3).

[ { "ade": "platelet count decreased", "drug": "lansoprazole" } ]

Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses.

[ { "ade": "RS", "drug": "aspirin" } ]

Sustained monomorphic ventricular tachycardia after adenosine infusion.

[ { "ade": "Sustained monomorphic ventricular tachycardia", "drug": "adenosine" } ]

Sensorimotor polyneuropathy with 5-aminosalicylic acid: a case report.

[ { "ade": "Sensorimotor polyneuropathy", "drug": "5-aminosalicylic acid" } ]

Linear immunoglobulin A bullous dermatosis induced by gemcitabine.

[ { "ade": "Linear immunoglobulin A bullous dermatosis", "drug": "gemcitabine" } ]

Sustained ventricular tachycardia in a thalidomide-treated patient with primary plasma-cell leukemia.

[ { "ade": "Sustained ventricular tachycardia", "drug": "thalidomide" } ]

In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine.

[ { "ade": "inhibition of hematopoiesis", "drug": "D-penicillamine" } ]

A case of pyridoxine-dependent seizures is reported.

[ { "ade": "seizures", "drug": "pyridoxine" } ]

This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.

[ { "ade": "acute interstitial pneumonitis", "drug": "hydroxyurea" } ]

Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.

[ { "ade": "hyperthyroidism", "drug": "IFN-alpha" } ]

We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.

[ { "ade": "fever", "drug": "epoprostenol" }, { "ade": "scaling", "drug": "epoprostenol" }, { "ade": "vomiting", "drug": "epoprostenol" }, { "ade": "rapidly progressive erythema", "drug": "epoprostenol" }, { "ade": "nausea", "drug": "epoprostenol" } ]

The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.

[ { "ade": "hypotension", "drug": "verapamil" } ]

OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.

[ { "ade": "NMS", "drug": "fluphenazine" }, { "ade": "neuroleptic malignant syndrome", "drug": "fluphenazine" } ]

Dipyrone-induced granulocytopenia: a case for awareness.

[ { "ade": "granulocytopenia", "drug": "Dipyrone" } ]

Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.

[ { "ade": "Imidazoline intoxication", "drug": "Imidazoline" } ]

A patient with severe cholestatic jaundice induced by captopril is presented.

[ { "ade": "severe cholestatic jaundice", "drug": "captopril" } ]

However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable.

[ { "ade": "liver injury", "drug": "troglitazone" } ]

Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.

[ { "ade": "SLE", "drug": "carbamazepine" } ]

A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.

[ { "ade": "B-cell lymphoma", "drug": "razoxane" } ]

We report a case of a patient with rheumatoid arthritis treated with low-dose methotrexate (15 mg/week) who developed infection with both M. tuberculosis and M. chelonae after the revision of a prosthetic hip.

[ { "ade": "infection with both M. tuberculosis and M. chelonae", "drug": "methotrexate" } ]

Erosion of psoriatic plaques: an early sign of methotrexate toxicity.

[ { "ade": "Erosion of psoriatic plaques", "drug": "methotrexate" }, { "ade": "methotrexate toxicity", "drug": "methotrexate" } ]

The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.

[ { "ade": "fungal infections", "drug": "alemtuzumab" }, { "ade": "opportunistic infections", "drug": "alemtuzumab" } ]

The literature of vincristine optic nerve toxicity is reviewed.

[ { "ade": "optic nerve toxicity", "drug": "vincristine" } ]

Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.

[ { "ade": "LABD", "drug": "Vancomycin" } ]

OBJECTIVE: To report a case of toxin-positive Clostridium difficile-induced colitis (CDIC) after use of clindamycin phosphate vaginal cream.

[ { "ade": "toxin-positive Clostridium difficile-induced colitis", "drug": "clindamycin phosphate" } ]

This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.

[ { "ade": "bilateral avascular necrosis of the femoral heads", "drug": "dexamethasone" } ]

Penicillin-induced Jarisch-Herxheimer reaction.

[ { "ade": "Jarisch-Herxheimer reaction", "drug": "Penicillin" } ]

CASE SUMMARY: A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness) presented with JHR after an initial intravenous dose of penicillin G for presumed neurosyphilis.

[ { "ade": "JHR", "drug": "penicillin G" } ]

Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.

[ { "ade": "renal tubular dysfunction", "drug": "sulfamethoxazole-trimethoprim" }, { "ade": "Hyperkalaemia", "drug": "sulfamethoxazole-trimethoprim" } ]