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RESULTS | More participants receiving dapagliflozin had vulvovaginitis , balanitis , or urinary tract infection . |
CONCLUSIONS | When added to a usual background regimen in an older population with advanced T2DM and preexisting comorbid CVD , dapagliflozin improved glycemic control without an increase in hypoglycemic risk , promoted weight loss , and was well tolerated . |
###24565750 | null |
OBJECTIVE | A recent international , multicenter , double-blinded , randomized trial shows delayed-enhanced magnetic resonance imaging ( DE-MRI ) using contrast doses of 0.2 mmol/kg is effective in the detection and assessment of myocardial infarction ( MI ) , and 0.1 mmol/kg is not enough ; intermediate doses between 0.1 and 0.2 mmol/kg have not been tested . |
OBJECTIVE | The aim of this study was to prospectively test the performance of DE-MRI using 0.15 mmol/kg of contrast agent for the detection of MI . |
METHODS | A total of 31 consecutive patients with chronic MI underwent DE-MRI at 3.0 T using both 0.15 mmol/kg and 0.2 mmol/kg of contrast agent in random order and on separate days . |
METHODS | Infarction segment and infarction size were compared on DE-MRI images using a 17-segment model . |
METHODS | Bland-Altman analysis was used to analyze correlation and agreement between global infarct sizes . |
RESULTS | DE-MRI showed enhanced myocardium in all the 31 patients with chronic MI . |
RESULTS | There was no significant difference between the 0.15 mmol/kg and 0.2 mmol/kg images in all 31 patients based on the infarction segment ( 7.872.72 vs. 7.812.64 , respectively ; p = 0.33 ) . |
RESULTS | There was no significant difference between the infarction size obtained from 0.15 mmol/kg acquisition and that from 0.2 mmol/kg acquisition ( 16.37.8 % vs. 16.47.9 % , respectively ; p = 0.87 ) . |
RESULTS | A strong correlation between the infarction size obtained from 0.15 mmol/kg acquisition and that from 0.2 mmol/kg acquisition was indicated through Bland-Altman analysis . |
CONCLUSIONS | DE-MRI at 3.0 T using 0.15 mmol/kg of contrast agent is effective for the assessment of MI . |
###24468920 | null |
OBJECTIVE | A sudden gain is defined as a large and stable individual improvement occurring between two consecutive treatment sessions . |
OBJECTIVE | Sudden gains have been shown to predict better long-term improvement in several treatment studies , including cognitive behavioural therapy for depression and anxiety disorders , but have not been studied in the treatment of health anxiety or any form of internet-based cognitive behavioural therapy . |
OBJECTIVE | The aim of this study was to investigate the role of sudden gains in internet-based cognitive behavioural therapy for severe health anxiety . |
METHODS | We examined the occurrence and significance of sudden gains in measures of health anxiety in 81 participants receiving internet-based cognitive behavioural therapy . |
METHODS | We compared patients with sudden gains , patients without sudden gains , and patients with gradual gains . |
RESULTS | Thirteen participants ( 16 % ) experienced one sudden gain in health anxiety with individual sudden gains distributed across the treatment . |
RESULTS | As expected , patients with a sudden gain showed larger improvements than patients without a sudden gain at post-treatment ( d = 1.04 ) and at one-year follow-up ( d = 0.91 ) on measures of health anxiety . |
CONCLUSIONS | Consistent with previous studies , sudden gains in internet-based cognitive behavioural therapy are associated with significantly larger and stable treatment effects up to one-year follow-up . |
###25534310 | null |
BACKGROUND | Same-sex attracted young adults have been found to experience higher rates of mental health problems and greater difficulties in accessing specialist mental health care services compared to their heterosexual peers . |
BACKGROUND | Internet-based mental health interventions have the potential to be more engaging and accessible to young adults compared to those delivered face-to-face . |
BACKGROUND | However , they are rarely inclusive of lesbian women and gay men . |
BACKGROUND | Thus , the current study aims to evaluate the effectiveness of an online mental health and wellbeing program , Out & Online ( http://www.outandonline.org.au ) , in comparison to a wait-list control group , for reducing anxiety and depressive symptoms in same-sex attracted young adults aged between 18 and 25 years . |
METHODS | We are recruiting , through media and community organisations , 200 same-sex attracted young adults with anxiety and/or depressive symptoms and mild to moderate psychological distress ( Kessler-10 score between 16 to 21 ) . |
METHODS | Participants will be randomly allocated to the intervention ( the online program ) or the wait-list control group based on a permuted blocked randomisation method to allow for stratification by gender . |
METHODS | Participants in the intervention group will receive a tailored program for up to three types of mental health difficulties simultaneously . |
METHODS | The primary outcome of anxiety and/or depressive symptoms , and secondary outcomes related to psychological distress , wellbeing and health behaviour will be measured at pre-intervention ( 0 week ) , post-intervention ( 8 weeks ) and at a 3-month follow-up ( 20 weeks ) . |
CONCLUSIONS | This online mental health and wellbeing program will be one of the first online interventions to be designed specifically to be relevant for same-sex attracted individuals . |
CONCLUSIONS | If the program is found to be effective it will improve access to specialist same-sex attracted-relevant mental health services for young adults and will facilitate wellbeing outcomes for these individuals . |
CONCLUSIONS | This program will also be a significant development in the delivery of tailored interventions that target multiple types of mental health conditions simultaneously . |
BACKGROUND | Australian New Zealand Clinical Trials Registry : ACTRN12611000700932 . |
BACKGROUND | Date registered : 7 July 2011 . |
###24996447 | null |
BACKGROUND | Endometriosis affects fertility negatively . |
BACKGROUND | The study aims to evaluate whether laparoscopic surgery combined with oral contraceptive or herbs were more effective than laparoscopic alone in improving fecundity and pelvic pain in women with minimal/mild endometriosis . |
METHODS | A randomized controlled trial ( RCT ) was conducted in 156 infertile women with minimal/mild endometriosis . |
METHODS | After laparoscopic surgery , patients were randomized to three groups : in Group A ( n = 52 ) oral contraceptive ( OC ) was administered one pill a day , continuous for 63days without intervals , in Group B ( n = 52 ) OC was administered as above and then Dan ' e mixture was added 30g/day for the latter 30days , and in control Group C ( n = 52 ) patients tried to get pregnant after surgery without complementary treatment . |
METHODS | The follow-up periods were 12months in Group C and 14months in complementary medical treatment Group A and B. |
METHODS | The pregnant women were further followed up , and labor and pregnancy outcomes were assessed . |
METHODS | Primary outcome was pregnancy rate ( PR ) and live birth rate ( LBR ) . |
METHODS | Secondary outcomes included changes of pelvic pain visual analog scale scores and side effects . |
METHODS | Analyses were done as intention-to-treat . |
RESULTS | The PR was 46.80 % ( 73/156 ) , and the LBR was 69.86 % ( 51/73 ) . |
RESULTS | Of the 73 pregnancies , 60 occurred within 12months of follow-up and 7 of the remaining 13 patients underwent assisted reproductive technology for > 1year . |
RESULTS | No significant difference was observed in PR and LBR among the three groups . |
RESULTS | Patients given medical treatment ( OCs or OCs plus herbal medicine ) had significantly decreased pain scores compared with the laparoscopy alone group . |
CONCLUSIONS | Combination of laparoscopy with OCs or OCs and herbal medicine does not have more advantages than laparoscopy alone in improving fertility of women with minimal/mild endometriosis . |
BACKGROUND | ChiCTR-TRC-11001820 . |
###24393346 | null |
OBJECTIVE | To explore the effect of continuous nursing intervention guided by chronotherapeutics so as to provide the easy , noninvasive , effective and acceptable intervention for older hypertensive patients in the community . |
BACKGROUND | Many researchers studied the effect of administration at different times on blood pressure control and circadian rhythm . |
BACKGROUND | However , the individual administrative time was set ambiguously in previous studies . |
METHODS | A semi-experimental study . |
METHODS | In the study , 90 eligible patients were recruited and separated into three groups randomly , which were the control group , intervention group A ( behaviour and chronotherapy intervention ) and intervention group B ( behaviour intervention ) . |
METHODS | At 6 and 12months after the study , the intervention groups were measured 24-hour ambulatory blood pressure monitoring . |
RESULTS | There were significant differences in ambulatory blood pressure monitoring parameters of the two intervention groups at different measurement times , and there were interaction between measurement time and different groups . |
RESULTS | The number of patients with dipper increased and reverse dipper decreased in group A as the intervention applied . |
RESULTS | There were statistical differences between two groups . |
RESULTS | The number of patients with morning surge in group A decreased more , and there were statistical differences between two groups at six months after the intervention . |
CONCLUSIONS | The behaviour and chronotherapy intervention based on the patients ' ambulatory blood pressure monitoring can control casual blood pressure much better and last longer , which can also improve patients ' indexes of ambulatory blood pressure monitoring better than behaviour intervention only . |
CONCLUSIONS | The behaviour and chronotherapy intervention can increase patients ' nocturnal blood pressure drop , increase the number of patients with dipper and decrease reverse dipper , and improve blood pressure surge in the morning . |
CONCLUSIONS | Nurses can use continuous nursing intervention guided by chronotherapeutics to help improve hypertension of older patients better in the community . |
###24262772 | null |
OBJECTIVE | To test the impact of the method of administration ( MOA ) on score level , reliability , and validity of scales developed in the Patient Reported Outcomes Measurement Information System ( PROMIS ) . |
METHODS | Two nonoverlapping parallel forms each containing eight items from each of three PROMIS item banks ( Physical Function , Fatigue , and Depression ) were completed by 923 adults with chronic obstructive pulmonary disease , depression , or rheumatoid arthritis . |
METHODS | In a randomized crossover design , subjects answered one form by interactive voice response ( IVR ) technology , paper questionnaire ( PQ ) , personal digital assistant ( PDA ) , or personal computer ( PC ) and a second form by PC , in the same administration . |
METHODS | Method equivalence was evaluated through analyses of difference scores , intraclass correlations ( ICCs ) , and convergent/discriminant validity . |
RESULTS | In difference score analyses , no significant mode differences were found and all confidence intervals were within the prespecified minimal important difference of 0.2 standard deviation . |
RESULTS | Parallel-forms reliabilities were very high ( ICC = 0.85-0 .93 ) . |
RESULTS | Only one across-mode ICC was significantly lower than the same-mode ICC . |
RESULTS | Tests of validity showed no differential effect by MOA . |
RESULTS | Participants preferred screen interface over PQ and IVR . |
CONCLUSIONS | We found no statistically or clinically significant differences in score levels or psychometric properties of IVR , PQ , or PDA administration compared with PC . |
###24503689 | null |
METHODS | Prospective randomized study . |
OBJECTIVE | This study aimed to prospectively compare the surgical results of the open - and French-door laminoplasty . |
BACKGROUND | Cervical laminoplasty is a common surgical procedure for the treatment of cervical compressive myelopathy . |
BACKGROUND | These procedures are primarily classified as either open - or French-door laminoplasties . |
BACKGROUND | Only few prospective studies comparing the surgical results of the 2 procedures are available . |
METHODS | A total of 92 patients with cervical compressive myelopathy who underwent cervical laminoplasty were prospectively enrolled and randomized into the following 2 groups according to the type of laminoplasty : open-door and French-door groups . |
METHODS | A single attending spine surgeon performed all surgical procedures . |
METHODS | The following factors were evaluated : surgical duration , blood loss , perioperative complications , neurological assessment using the Japanese Orthopedic Association score , and recovery rate . |
METHODS | Radiological evaluations included assessment of the cervical lordotic angle and cervical range of motion . |
METHODS | In addition , the ratio of postoperative spinal lamina opening was evaluated by magnetic resonance imaging . |
RESULTS | There were no differences in perioperative complications and neurological outcomes between the 2 groups . |
RESULTS | The mean reduction in cervical lordotic angle after surgery was significantly greater in the open-door group than the French-door group ( 3.0 vs. 5.6 ) . |
RESULTS | Postoperative cervical range of motion significantly decreased in the open-door group than in the French-door group ( 19.3 vs. 26.0 ) . |
RESULTS | Postoperative cervical lordotic angle in the extension position significantly diminished in the open-door group than in the French-door group ( 7.9 vs. 14.1 ) . |
RESULTS | The ratio of opening of the spinal lamina after surgery was significantly larger in the open-door group than in the French-door group . |
CONCLUSIONS | The 2 laminoplasty methods showed almost the same neurological recovery as well as perioperative complications . |
CONCLUSIONS | In cases of open-door laminoplasty , postoperative cervical alignment became more kyphotic and cervical range of motion was more restricted than that in French-door laminoplasty cases after surgery . |
CONCLUSIONS | French-door laminoplasty is preferable to open-door laminoplasty for postoperative cervical alignments . |
METHODS | 1 . |
###24648359 | null |
BACKGROUND | Burnout is a very prevalent type of stress among health professionals . |
BACKGROUND | It affects their well-being , performance , and attitude toward patients . |