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- The menu will include German potato soup with beef sausages, Oxtail soup, crispy veal knuckle, Rheinischer Sauerbraten (braised piece of marinated beef) and a live cooking station for the traditional Wiener Schnitzel.
- 1 Season with salt, pepper, and paprika. 2 Dip in flour, then beaten eggs and in the bread crumbs. 3 Heat butter crisco in large skillet and place schnitzel in pan. Brown well on both side in pan on medium heat for abut 15 to 20 munutes.
Vienna Austrian capital, capital of Austria, Vienna - the capital and largest city of Austria; located on the Danube in northeastern Austria; was the home of Beethoven and Brahms and Haydn and Mozart and Schubert and Strauss.
- The visit to Wounded Knee is a pilgrimage to remembrance, to there where we are driven to be mindful of and reflect upon the sad choices that we humans sometimes make, and worse, the persistent, continued widespread endorsement that those choices receive... Wounded Knee is well-marked on the map and easy to get to.
- I am planning a visit to Wounded Knee this summer with my two granddaughters (11,10). I am a 74 year old woman traveling alone with them. Is it a safe place to take them. I have longed to visit the place and have great sympathy for what our government did to the native americans.
- My husband and I traveled to the Wounded Knee Monument on our Western Tour '16. It was difficult I find, but I was looking forward to arriving and stepping into a museum that would give me information about the history, characters, and other facts about the terrible massacre that occurred there.
Wounded Knee Massacre The previous day, a detachment of the U.S. 7th Cavalry Regiment commanded by Major Samuel M. Whitside intercepted Spotted Elk's band of Miniconjou Lakota and 38 Hunkpapa Lakota near Porcupine Butte and escorted them 5 miles (8.0 km) westward to Wounded Knee Creek, where they made camp.
U.S. Army massacres Indians at Wounded Knee A brutal massacre followed, in which it’s estimated 150 Indians were killed (some historians put this number at twice as high), nearly half of them women and children. The cavalry lost 25 men. The conflict at Wounded Knee was originally referred to as a battle, but in reality it was a tragic and avoidable massacre.
- So happy to finally make the trip to pay my respect to those killed and Wounded Knee Creek on 12/29/1890 and burred here in a mass grave in this active cemetery. Also paid respect to some killed at this site in 1973 in a stand off with the Federal Government, the American Indian Movement and tribal leaders.
Wounded Knee Massacre Wounded Knee Massacre. Not to be confused with Wounded Knee incident. The Wounded Knee Massacre occurred on December 29, 1890, near Wounded Knee Creek (Lakota: Čhaŋkpé Ópi Wakpála) on the Lakota Pine Ridge Indian Reservation in the U.S. state of South Dakota.
Wounded Knee Massacre More than 80 years after the massacre, beginning on February 27, 1973, Wounded Knee was the site of the Wounded Knee incident, a 71-day standoff between militants of the American Indian Movement—who had chosen the site for its symbolic value—and federal law enforcement officials.
- Wounded Knee, located on the Pine Ridge Indian Reservation in southwestern South Dakota,was the site of two conflicts between North American Indians and representatives of the U.S. government. An 1890 massacre left some 15 0Native Americans dead, in what was the final clash between federal troops and the Sioux. In 1973, members of the American Indian Movement occupied Wounded Knee for 71 days to protest conditions on the reservation. Play video.
- Wounded Knee is a place for education, rememberance, and respect. It's a fantastic visit and trip to make if you wish to understand the incident and respect the traditions and values of 19th century Native Americans.
Subpart 33.1âProtests “Interested party for the purpose of filing a protest” means an actual or prospective offeror whose direct economic interest would be affected by the award of a contract or by the failure to award a contract.
Part 533â Protests, Disputes, and Appeals 533.103 Protests to the agency. 533.103-1 Filing a protest. (a) Any protester filing an agency protest has the choice of requesting either that the contracting officer or the Agency Protest Official decide the protest. If the protest is silent on this matter, the contracting officer will decide the protest.
Legal Resources To file a bid protest, a protestor must demonstrate that it has standing as an interested party, meaning the protestor must be an actual or prospective offeror whose direct economic interest would be affected by the award of a contract or by the failure to award a contract.
- This part prescribes policies and procedures for filing protests and for processing contract disputes and appeals. There are other Federal court-related protest authorities and dispute-appeal authorities that are not covered by this part of the FAR, e.g., 28 U.S.C. 1491 for Court of Federal Claims jurisdiction.
Part 533â Protests, Disputes, and Appeals An agency protest is filed when the complete protest is received at the location the solicitation designates for serving protests. GSA’s hours of operation are 8 a.m. to 4:30 p.m. Protests delivered after 4:30 p.m. will be considered received and filed the following business day.
A GAO Reminder: Know Your Protest Filing Deadline Contrary to a common misconception, a protest is not always timely if filed within 10 days of a debriefing. As one prospective protester learned, if the debriefing is not “required” under applicable law, a GAO protest filed within 10 days of a debriefing might be untimely. GAO regulations set specific (and strict) protest filing deadlines. Protests relating to improprieties in the solicitation itself, for example, must be filed before the bid opens or the time set for receipt of initial proposals. 4 C.F.R. § 21.2(a)(1).
Subpart 33.1âProtests (f) No person may file a protest at GAO for a procurement integrity violation unless that person reported to the contracting officer the information constituting evidence of the violation within 14 days after the person first discovered the possible violation (41 U.S.C. 2106).
Part 533â Protests, Disputes, and Appeals 533.103-1 Filing a protest. ( 1 a) Any protester filing an agency protest has the choice of requesting either that the contracting officer or the Agency Protest Official decide the protest. ( 2 b) If an agency protest is filed, the deciding official uses the procedures in FAR 33.103 and this section to resolve the protest.
Legal Resources A contractor challenging a federal procurement may generally choose to file a bid protest before the agency administering the procurement, the Government Accountability Office (GAO), or the U.S. Court of Federal Claims (COFC).
Legal Resources To obtain a CICA stay, the protestor only needs to file its protest within 10 days of the contract award or within five days of its debriefing. However, the requirement for a CICA stay is not triggered until GAO provides notice of the protest filing to the contracting agency.
What is the largest island in the world located near Canada? Greenland is the largest island in the world at 840,000 square miles (2,175,590 km2).
Pacific islands which country has owns the world's largest number of coral reefs. indonesia. island-de-pascua is another name for what chilean island. easter island. which european country owns the world's largest number of coral reefs because of its ownership of several pacific ocean reefs. france.
The smallest island in the world and its dark past In that spirit, the Guinness Book of World Records gave its “Smallest Island” award to Bishop Rock, the westernmost of the Isles of Scilly, which lie off Britain’s south-western tip, the peninsula of Cornwall. View over to Bishop Rock. Picture: Tim Dobson.Source:Flickr.
Largest Islands in the World Updated March 03, 2017. Below you will find a list of the largest islands in the world based on size or area followed by a list of the largest islands in the world based on population. 1. Greenland - North America - 840,004 square miles - 2,175,600 sq km. 2. New Guinea - Oceania - 312,167 square miles - 808,510 sq km.
"The ""Longest"" Islands in the United States" 21 of the 29 islands on the following chart are in Alaska, and 3 more are in Hawaii. Technically, Alaska actually is continental, but even if the more correct term contiguous United States is used to describe the lower 48, Whidbey Island still ranks only 5th in length.
The smallest island in the world and its dark past THE largest island in the world is Greenland. Probably. You have to disqualify all the bigger landmasses as continents, and ignore the possibility that Greenland might actually be three smaller islands connected by an ice sheet.
What is the largest island in the world located near Canada? Greenland is considered the world's largest island and it is situated in the Arctic Ocean to the north east of Canada.
- The Caspian Sea is the largest lake in the world. ------------------------------------------------------------------------- The area of Caspian Sea is 3 626 000 km…2. Around the Caspian Sea are the following countries: Russia, Azerbaijan, Iran, Turkmenistan, Kazakhstan.
"The ""Longest"" Islands in the United States" One superlative remains: Whidbey Island is indeed the longest island on the Pacific coast of the contiguous United States. This is mainly due to lack of competition from the almost island-free coasts of California and Oregon, though.
"The ""Longest"" Islands in the United States" Whidbey Island in Washington state is always calling itself the longest island in the United States, or the longest island in the continental United States, or, sometimes, the longest saltwater-surrounded island in the continental United States.
Vegito Super Vegito overwhelms Buu with power, beating the monster to a pulp. Eventually beginning to toy with Buu, Buu uses his magic to transform Vegito into a piece of candy. Despite his form, Vegito retains all of his physical strength and control, beating Buu down further with intense speed.
- . - Vegetto, asking Vegeta and Goku how they defeated Buu. For information regarding Vegetto as he appears in Dragon Ball Z, go to Dragon Ball Wiki. Vegetto (spelt Vegito in some English translations) is the fusion of Goku and Vegeta through the use of the Potala Earrings. In Universe 16, Vegetto never unfused after entering Buu's body, and went on to father Gohan, Goten, Trunks and Bra.
Vegito It isn't until Vegito appears inside Buu that it is revealed that it was all a plan by Vegito to rescue Piccolo, Goten, Trunks, and Gohan. Thanks to a barrier formed by Vegito, he is not absorbed into a pod like the others. Once the barrier is let down, Vegito defuses back into Goku and Vegeta.
Vegito Despite his pride, Vegeta, to save his only son, agrees to the fusion. Together, Goku and Vegeta fuse to become the fighter Vegito. Vegito is incredibly powerful upon his original appearance, beating Buu easily. Once Buu decides to use his absolute power, Vegito turns into a Super Saiyan. Super Vegito is statistically the most powerful character in the Dragon Ball Z storyline.
Vegito Vegito is able to transform into a Super Saiyan, calling himself Super Vegito (or Super Vegerot in the English manga) in this form. As a Super Saiyan, he gains a slight increase in muscle mass, bluish-green eyes, very defined golden hair and eyebrows and a golden aura (with occasional surges of blue electricity).
Vegito Vegito is born. Vegito before transforming into a Super Saiyan. Vegito is a fusion formed out of desperation by Goku and Vegeta in an effort to stop Super Buu, an ancient and powerful being whose only purpose is to destroy.
- — . The Incredible Fighting Candy . Vegito cannot transform into this form willingly, he takes the form of a coffee-flavored jawbreaker after being turned into it by Super Buu. Super Buu turns Vegito so that he can consume him, but Vegito is still able to fight as a small candy.
- Character » appears in 31 games. Goku and Vegeta fuse using the Potara Earrings to become Vegito, the most powerful character in the entire Dragon Ball Z storyline. With the strengths of the two greatest Saiyans, Vegito knows no equal in DBZ.
Vegito Vegito's personality is a mixture of both Goku and Vegeta's characteristics. He exhibits Vegeta's cockiness and inclination for taunting others, and playing around with his enemies, wanting them to suffer, but is not as serious, having inherited Goku's easygoing, cheerful nature, easily toying with his opponents.
Vegito The Potara Earring Fusion used to form Vegito is what Old Kai considers to be the proper way to do fusion, as opposed to the Fusion Dance technique. The resulting fusion lasts forever, even if the fused being removes the earrings.
Lyme disease Lyme disease, also known as Lyme borreliosis, is an infectious disease caused by bacteria of the Borrelia type. The most common sign of infection is an expanding area of redness, known as erythema migrans, that begins at the site of a tick bite about a week after it has occurred.
Lyme disease Lyme disease is transmitted to humans by the bite of infected ticks of the Ixodes genus. Usually, the tick must be attached for 36 to 48 hours before the bacteria can spread. In North America, Borrelia burgdorferi sensu stricto and Borrelia mayonii are the cause.
Are mood swings a symptom of lyme disease? Lyme Disease has many symptoms including fever, sweats, chills, flushing, weight changes, fatigue and tiredness, swollen glands, sore throat, pelvic pain, urinary problems, loss of libido, upset stomach, stiffness in the joints, back and neck, muscle pain, cramps, twitching, headaches, tingling, numbness, burning and stabbing sensations, facial ...
Are mood swings a symptom of lyme disease? Lyme disease causes depression, which can cause mood swings. Additionally, the pain associated with Lyme is enough to cause patients to become irritable. Lyme disease is a systemic infection that can affect all systems of the human body. This disease is a bacterial infection transmitted by the spirochete, Borrelia burgdorferi.
- Thinking Problems. Concentration. Memory. Thinking. Making decisions. Neurological Symptoms. Lyme disease can cause physical, cognitive, and psychiatric symptoms. Symptoms may come and go from week to week, day to day, or even during the day. They can vary in intensity throughout the day. A person can suddenly get a terrible pain in the knee.
- Lyme Disease and depression. Depression. It isn't all in your head. Some of the symptoms related to the brain and nervous systems that have been observed in Lyme patients are headache, tremor, facial paralysis (Bell's palsy), tremor, burning or sharp stabbing sensations, numbness, irritability, dementia, and mood swings.
Thinking, Neurological, and Mood Issues with Lyme Neurological Symptoms. 1 Lyme disease can cause physical, cognitive, and psychiatric symptoms. 2 Symptoms may come and go from week to week, day to day, or even during the day. 3 They can vary in intensity throughout the day. A person can suddenly get a terrible pain in the knee.
Lyme Disease and depression // Filed in: Lyme Disease Symptoms. Depression. It isn't all in your head. Some of the symptoms related to the brain and nervous systems that have been observed in Lyme patients are headache, tremor, facial paralysis (Bell's palsy), tremor, burning or sharp stabbing sensations, numbness, irritability, dementia, and mood swings.
Lyme Disease and depression If you are unusually depressed, or your mood swings are worsening, and you also have some of the other symptoms associated with the disease, such as crushing fatigue, fever, rash, or arthritis, it is very important to consult a Lyme-literate doctor with experience in recognizing Lyme symptoms.
Lyme disease Not all patients with Lyme disease have all symptoms, and many of the symptoms are not specific to Lyme disease, but can occur with other diseases, as well. The incubation period from infection to the onset of symptoms is usually one to two weeks, but can be much shorter (days), or much longer (months to years).
ARROW: WHO IS DAMIEN DARHK? The Season 4 Villain? HIVE's leader? Connected to just about every character? HUGE Theories! Damien Darhk's description from Ra's doesn't equate to his comic counterpart- but it's possible the writers have amalgamated two characters. Doctor Ebeneezer Darrk was assigned by Ra's to head the League of Assassins, who accordingly holds his own mini league of followers.
Damian Wayne Damian Wayne. Damian Wayne or Damian al Ghul (Arabic: داميان الغول) is a fictional superhero appearing in American comic books published by DC Comics, commonly in association with Batman. He is the son of Batman and Talia al Ghul (Arabic: تاليا الغول), and thus the grandson of Batman villain Ra's al Ghul.
- Damian is flustered by Superman's sudden appearance, and Superman asks if Batman is in. When Nightwing confirms he is at his computer, Damian interjects that his father has been, Broodier then usual.. Superman merely responds that his father is the master of brooding.
- Damian Wayne is a fictional character in the DC Universe. Damian is the child of Bruce Wayne and Talia al Ghul and thus the grandson of Batman's villain, Ra's al Ghul. The character was created by Mike W. Barr, and first appeared in Batman: Son of the Demon (1987).
- This version of Damian Wayne is in a future where Damian becomes Batman after he is unable to save the second Batman from being killed by an unknown killer. Damian has some supernatural power, is willing to kill, as well as having a cat he has named Alfred. Robin: Judge, Jury, Executioner.
ARROW: WHO IS DAMIEN DARHK? The Season 4 Villain? HIVE's leader? Connected to just about every character? HUGE Theories! Ra's al Ghul's description matches neither character perfectly, but together it does. Ra's says that Damien has a hive of followers - it would seem, in this universe, Darhk heads HIVE, who are his own loyalists who departed the League of Assassins alongside him.
Damian Wayne Damian Wayne as Nightwing is a playable character, as the Regime Costume for Nightwing in Injustice: Gods Among Us. He is classified as a Gadget user. He is an agile fighter, and can combine his dual sticks into a large staff.
Batman and Son Batman and Son. Batman and Son is a 2006 comic book story arc featuring the DC Comics character Batman. Written by Grant Morrison and drawn by Andy Kubert, the story was published in four parts in the comic book Batman starting in #655 and ending in #658.
ARROW: WHO IS DAMIEN DARHK? The Season 4 Villain? HIVE's leader? Connected to just about every character? HUGE Theories! Many speculated that this could mean Damien Wayne, son of the Dark Knight, who has connections to Ra's, but that seemed unlikely (edit: ironically, it's come to my attention the Facebook page for Moviepilot actually shared this as Damien Wayne. That's an error such as the one above).
Damian Wayne (Batman in Bethlehem) This version of Damian Wayne is in a future where Damian becomes Batman after he is unable to save the second Batman from being killed by an unknown killer. Damian has some supernatural power, is willing to kill, as well as having a cat he has named Alfred. Revenge Quest.
Pam Beesly Roy flies into a violent rage and Pam ends the relationship on the spot. The next day, Roy attempts to attack Jim in the office but is stopped by Dwight's pepper spray and is fired. After losing his job, Roy meets Pam for coffee and says that even though Jim is dating Karen, she should at least make an effort to date him, as she called off the wedding because of him.
The Office: Where are they now? The Office brought the workplace comedy to new heights and provided a platform to showcase the talents of individuals who have gone on to become some of the biggest names in Hollywood. Ahead, find out where they are now.
The Office: Where are they now? Krasinski broke out as the deadpan, lovelorn, prank-loving Jim Halpert, earning legions of fans for his quiet yearning for office receptionist Pam (Jenna Fischer) in one of the greatest sitcom love stories.
The Office: Where are they now? A comedian on the improv circuit, Kemper was best known for viral internet sketches before joining The Office as new receptionist Erin Hannon when Pam moved into a sales job. She then went on to appear in films like Bridesmaids, The Secret Life of Pets, and 21 Jump Street, as well as TV series including The Mindy Project, Sofia the First, and Drunk History.
Pam Halpert Trivia. 1 Pam is an accomplished volleyball player, a talent not revealed until the Company Picnic. 2 Since season 7 episode 2 Counseling Pam is the official office administrator. However, Pam lied to get the position as office administrator and was nearly caught by Gabe. Pam has the final talking head interview in the series, during which she delivers the final line of the series: There's a lot of beauty in ordinary things.
The Office: Where are they now? Since The Office ended, she’s had recurring roles on several short-lived TV shows, including The Mysteries of Laura and You, Me, and the Apocalypse. She will next be seen in The 15:17 to Paris, Clint Eastwood’s film based on the true story of a terrorist attack on a European train.
Pam Halpert 1 Pam is an accomplished volleyball player, a talent not revealed until the Company Picnic. 2 Since season 7 episode 2 Counseling Pam is the official office administrator. However, Pam lied to get the position as office administrator and was nearly caught by Gabe.
Pam Halpert Pamela Pam Halpert (née Beesly) is a fictional character played by Jenna Fischer in the television series The Office. She is based on Dawn Tinsley in The Office UK. She is currently married to Jim Halpert and has two kids with him, a girl named Cecelia Cece Marie Halpert, and a boy named Phillip Halpert.
The Office: Where are they now? Kaling joined the sitcom as a member of the writing staff, but soon found her ditzy, romance-obsessed office worker Kelly Kapoor becoming a fan favorite. In 2010, she was nominated for an Emmy for writing “Niagara,” the episode where Jim and Pam get married.
Pam Halpert Pamela Pam Morgan Halpert (née Beesly) is a fictional character played by Jenna Fischer in the television series The Office. She is based on Dawn Tinsley in The Office UK. She is married to Jim...
How to Refill a PaperMate Sharpwriter Mechanical Pencil. The package says that they are non-refillable pencils; the thought is that you use it till it runs out of lead and then it's trash. BUT! That is a lie! You can refill them and I encourage you to do so. This video explains how to refill the pencil, complete with close-ups. Don't throw them away, refill them!
DMP - Mechanical Pencils This might sound stupid for all of you experienced users of mechanical pencils but...... first time user of a mechanical pencil(Pentel P205)-I have just used up my first piece of lead and need to refill it. BUT I can't figure it out. The lead will not stay in the opening.
- I hate regular wood pencils and I don't like those expensive refillable pencils either. I also don't like any mechanical pencil where you click the eraser part to bring out more 'lead'. For example, I tried one by BIC with the clicky eraser and I hated it including how it felt in my hand.
DMP - Mechanical Pencils I lost the instructions and can't understand how to refill this mechanical pencil. The end where the lead comes out keeps falling off. The back end where the eraser is located will not stay inside the barrel. There is a little spring, but the pieces do not work together at all.
- It's the only one I use. I hate regular wood pencils and I don't like those expensive refillable pencils either. I also don't like any mechanical pencil where you click the eraser part to bring out more 'lead'. For example, I tried one by BIC with the clicky eraser and I hated it including how it felt in my hand.
How do you refill a Papermate Sharpwriter mechanical pencil? RE: How do you refill a Papermate Sharpwriter mechanical pencil? It's one of those pencils that retracts or advances lead by twisting the portion at the bottom, but I don't know how to refill it. It's got a spring and this little black lead holder thing inside, which holds only one piece of lead at a time.
- How to remove oil Based Paste Ink: Hairspray is your best bet on this one! Lay the stain face down on a clean cloth or paper towel. Spray the back of the stain with an alcohol-based hairspray until it is wet and push the stain through the fabric, replacing the cloth or paper towel underneath as it absorbs the ink.
How to Refill a PaperMate Sharpwriter Mechanical Pencil. You can refill them and I encourage you to do so. This video explains how to refill the pencil, complete with close-ups. Don't throw them away, refill them! Remember, the Paper-Mate Sharpwriter pencil uses 0.7mm lead. Standard Pentel lead will work excellent. The video was recorded with a Sony EVO-210 Video 8 8mm VCR.
DMP - Mechanical Pencils . . as with someone in 2006, I cannot refill my Sensa Mechanical pencil. I know how to refill the lead container inside. But but earlier reading suggested that is a not an autorefill. But I cannot get lead to to insert from the writing end.
- To refill your PhD Multi Pen just unscrew barrel at grip area (squeeze grip & turn barrel counter clockwise), pull out empty refill or lead tube, replace refill (for pencil, place no more than two 0.5mm leads in lead tube and replace) by pushing it firmly into the empty slot, reattach grip to barrel.
Average Salary in Altus, Oklahoma About Altus Salaries In Altus, Oklahoma, the average salary is $36,398. Trends in wages are falling with a 0.1 percent decrease over last quarter as of Q2 2017.
- This page covers the rules and regulations of having a privately owned firearm on Altus Air Force Base.
- Altus participates in Wreaths Across America 97th AMXS members dominate Aircraft Maintenance Competition AETC explores learning possibilities through new pilot training program
Salaries in Altus AFB, OK How much do workers make in Altus AFB, OK? Choose a job title, and see what salary employees earn for that job in Altus AFB. Glassdoor's Altus AFB salary data is based on 5 reports of salaries, bonuses, wages, and hourly pay, submitted anonymously to Glassdoor by employees in Altus AFB, OK. Are you paid fairly? Get a free, personalized salary estimate.
- 97th Civil Engineer Squadron trains Altus Airmen; TRICARE Consolidations: Welcome TRICARE East; Altus participates in Wreaths Across America; 97th AMXS members dominate Aircraft Maintenance Competition; AETC explores learning possibilities through new pilot training program ; Altus AFB has new U.S. Air Force Reserves recruiter
Salaries in Altus AFB, OK Choose a job title, and see what salary employees earn for that job in Altus AFB. Glassdoor's Altus AFB salary data is based on 4 reports of salaries, bonuses, wages, and hourly pay, submitted anonymously to Glassdoor by employees in Altus AFB, OK. Upload a resume to easily apply to jobs from anywhere.
- This page lists the phone numbers, location and hours of service for numerous agencies and support services on Altus Air Force Base. altus.af.mil Altus Air Force Base updated their profile picture.
- Altus Air Force Base · December 24, 2017 at 7:17am · On December 16, 2017, the Altus community came together to place wreaths on the gravestones of fallen veterans in remembrance of the sacrifices they made defending our country.
- Real salaries at 1 companies in Altus AFB, OK. Reported anonymously by 5 Altus AFB employees. Glassdoor salary data for Altus AFB workers.
Average Salary in Altus, Oklahoma About Altus Salaries. In Altus, Oklahoma, the average salary is $36,398. Trends in wages are falling with a 0.1 percent decrease over last quarter as of Q2 2017. Popular jobs in Altus include Retail Store Manager, Human Resources (HR) Manager, and Registered Nurse (RN) which pay between $24,630 and $48,454 per year. Some popular Altus industries include Education, Local Government, and Flight Training. Altus's most popular employers are City of Altus, U.S. Air Force (USAF), and Western Oklahoma State College.
- Astrocytes B. Dendritic cells C. Langerhans cells D. T lymphocytes E. B lymphocytes Option D (T lymphocytes) is correct. Antigen Presenting Cells (APCs) are found primarily in the skin, lymph nodes, spleen and thymus. They may also be present throughout the diffuse lymphoid system.
Lymphocyte Main articles: T cell and B cell. T cells (thymus cells) and B cells (bone marrow-or bursa-derived cells) are the major cellular components of the adaptive immune response. T cells are involved in cell-mediated immunity, whereas B cells are primarily responsible for humoral immunity (relating to antibodies). The function of T cells and B cells is to recognize specific “non-self” antigens, during a process known as antigen presentation.
- Primary lymphoid tissues are the tissues in which lymphocytes are generated and differentiateinto mature naive naïve: lymphocytes these are the bone marrow For b, cells and the bone marrow andthe thymus For t; cells they will be discussed In chapter. 7
- Inlymph nodes (a) , spleen (b) and the Peyer’spatches of the small intestine (c) , the B cellzones are seen as defined follicles; functionallyequivalent areas, not all as well defined, arefound in all mucosal lymphoid tissues.Proliferating B cells are concentrated in thegerminal centers.
- Secondary lymphoid tissues arethe tissues in which immune responses are initiated, and the lymphatic vessels that connectthem to the tissues and the bloodstream and thus to sites of infection (Figure 1-18).
- Conversely, at sites of chronic inflammation, organized lymphoid tissue mayform: this is known as tertiary lymphoid tissue. Overview of the Immune Response Chapter 1 15 Figure 1-19 Secondary lymphoid tissues Thespecialized sites of T cell activation are coloredpurple; the sites of B cell activation are blue.
Lymphocyte They include natural killer cells (NK cells) (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic adaptive immunity), and B cells (for humoral, antibody-driven adaptive immunity). They are the main type of cell found in lymph, which prompted the name lymphocyte.