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0.419587 | 8be874107f004738be4d72e9de1d2e94 | Average effect sizes (I2 = 95.809). In these figures square and diamond signs show effect sizes. | PMC10057722 | life-13-00849-g006.jpg |
0.427441 | 288cc09176df4d68b145142902995ab4 | Minimum effect sizes (I2 = 95.289). In these figures square and diamond signs show effect sizes. | PMC10057722 | life-13-00849-g007.jpg |
0.424733 | 65ee1e1b4b214e6cb1dd6ccc2d477b23 | Maximum effect sizes (I2 = 97.383). In these figures square and diamond signs show effect sizes. | PMC10057722 | life-13-00849-g008.jpg |
0.422086 | 944192f9190a420098962c308cac5cac | Native structure and mature sequence of FimH. (A) The native structure of FimH, in the absence of any ligand (PDB ID: 3JWN) [17]. The selected peptide-analogues for the experimental study are located in the lectin domain, close to the loops forming part of the mannose-binding site. (Β) The amino acid sequence of FimH. The predicted APRs have been highlighted with light blue, while the experimentally studied APRs have been marked in different colors. More specifically, the segments colored in red, orange, green and purple depict the APRs 18ANVYVNLA25, 53TDYVTL58, 125LIAVLILRQT134, and 142FQFVWNIYAN151, respectively. Segments with low aggregation propensity are shown in grey. | PMC10058141 | pharmaceutics-15-01018-g001.jpg |
0.42449 | 67d0a2e3763b4902aa39e78d5beb5baa | Experimental results of the four peptide-analogues (A–D). 18ANVYVNLA25 (Ai), 125LIAVLILRQT134 (Ci) and 142FQFVWNIYAN151 (Di) self-assemble into straight and unbranched amyloid-like fibrils, with a diameter of approximately 100 Å (black arrows), which tend to interact laterally forming straight and twisted ribbons (black and white arrowheads, respectively). 53TDYVTL58 (Bi) forms amorphous and spherical (flat black arrows) aggregates. All X-ray diffraction patterns (Aii–Dii) are indicative of the “cross-β” structure, displaying a reflection at approximately 4.7 Å and a reflection at 9.39 Å, 9.39 Å, 10.75 Å, and 10.82 Å, corresponding to the distance between consecutive β-strands and the distance between packed β-sheets, respectively. ATR FT-IR spectra (1100–1800 cm−1) produced from thin hydrated films of the four peptide-analogues (Aiii–Diii) confirm their β-sheet secondary structure. All peptide-analogues exhibit the characteristic apple–green birefringence (Aiv–Div) that amyloids typically exhibit. | PMC10058141 | pharmaceutics-15-01018-g002.jpg |
0.536415 | 3cb914948ae8433399ed601686888267 | MD simulations of 18ANVYVNLA25, 53TDYVTL58, 125LIAVLILRQT134, and 142FQFVWNIYAN151 peptide-analogues. In every case, a solvent box containing five copies of each peptide-analogue was simulated for 500 ns. Peptide-analogues are shown as cartoons, utilizing PyMOL v.2.5.0 [32]. | PMC10058141 | pharmaceutics-15-01018-g003.jpg |
0.470817 | e0867df5914d4f95b7eeda7200bfb0ac | MD simulations of lectin domain-DEG-125LIAVLILRQT134 complex. (A) First (0 ns, left) and last (350 ns, right) frames of MD simulations. 125LIAVLILRQT134 peptide-analogue is colored green, and DEG is colored blue (N: N-terminal, C: C-terminal). (B) The number of hydrogen bonds formed between 125LIAVLILRQT134 peptide-analogue and FimH lectin domain. More bonds are formed by the end of the simulation. (C) The number of hydrogen bonds formed DEG and FimH lectin domain. The number of hydrogen bonds between the two molecules fluctuates during the simulation, with that being zero in most instances. | PMC10058141 | pharmaceutics-15-01018-g004.jpg |
0.442382 | 61f1566a6a15492c895d4a74e440fd9e | MD simulations of lectin domain-DEG-peptide-analogue complexes. In all three cases, the peptide-analogues moved away from the binding pocket of the lectin domain. 18ANVYVNLA25, 53TDYVTL58, 142FQFVWNIYAN151, and DEG are colored in red, purple, orange, and blue (N: N-terminal, C: C-terminal). | PMC10058141 | pharmaceutics-15-01018-g005.jpg |
0.400942 | 0441677a57724ed8a2cc3a724ebcdef3 | Number of times each FimH peptide-analogue, with zero (0), one (1), or two (2) substitutions, occurs in the proteomes of E. coli, M. musculus and H. sapiens. 18ANVYVNLA25 peptide-analogue’s sequence is found identical only in the E. coli proteome. Its sequence, when carrying 2 mutations, is found 4 times in E. coli and 3 times in the proteomes of M. musculus and H. sapiens, respectively. The sequence of 53TDYVTL58 peptide-analogue can be identified in one protein in the E. coli proteome and one protein in the M. musculus proteome. On the other hand, its sequence, when it carries one mutation, can be found in all proteomes. Specifically, it has 10 matches in E. coli proteome, 29 matches in M. musculus proteome and 33 matches in H. sapiens proteome. Additionally, when its sequence has two mutations, it displays 252, 1504 and 1394 matches in E. coli, M. musculus and H. sapiens proteomes, respectively. 125LIAVLILRQT134 peptide-analogue is found only in the sequence of FimH. No mutant form of it was detected in any of the proteomes. Similarly, 142FQFVWNIYAN151 peptide-analogue is found only in the sequence of FimH. | PMC10058141 | pharmaceutics-15-01018-g006.jpg |
0.48304 | 67cde48f28dc4e859b1e4979a2626282 | Prioritization by Epidemiological indicators. | PMC10058159 | pntd.0011166.g001.jpg |
0.491909 | bdfb29ed330e40118c91df85fda9536b | Prioritization by WASH indicators. | PMC10058159 | pntd.0011166.g002.jpg |
0.368191 | e0984e7369714118ae4dd24f47756994 | Epicurve showing the number of cholera cases reported by date of onset, Kenya, 2015–2019.Data source: Division of Disease Surveillance and Response, Ministry of Health, Kenya. | PMC10058159 | pntd.0011166.g003.jpg |
0.471107 | bc15d8fbc89645cd91adfb1fcdd2a920 | Priority sub-counties based on cholera MAI & Persistence, Kenya, 2015–2019.Link to base map layer: https://data.humdata.org/dataset/cod-ab-ken Link to terms of use: https://data.humdata.org/faqs/licenses. | PMC10058159 | pntd.0011166.g004.jpg |
0.434897 | ca286c4922234ebca0ba90facf0dbfda | Priority sub-counties based on WASH indicators, Kenya, 2015–2019.Link to base map layer: https://data.humdata.org/dataset/cod-ab-ken Link to terms of use: https://data.humdata.org/faqs/licenses. | PMC10058159 | pntd.0011166.g005.jpg |
0.419727 | a03d9a50be6b4507bf0a82ce39778ea9 | Priority sub-counties based on a combination of Epidemiological and WASH indicators, Kenya, 2015–2019.Link to base map layer: https://data.humdata.org/dataset/cod-ab-ken Link to terms of use: https://data.humdata.org/faqs/licenses. | PMC10058159 | pntd.0011166.g006.jpg |
0.459312 | 0cb12b75ec0449858d25d84c48ff50dc | . Priority sub-counties in Nairobi County based on a combination of Epidemiological and WASH indicators, 2015–2019.Link to base map layer: https://data.humdata.org/dataset/cod-ab-ken Link to terms of use: https://data.humdata.org/faqs/licenses. | PMC10058159 | pntd.0011166.g007.jpg |
0.429677 | 1640f5127ec54070a489eef8e74be780 | Priority sub-counties in Mombasa County based on a combination of Epidemiological and WASH indicators, 2015–2019.Link to base map layer: https://data.humdata.org/dataset/cod-ab-ken Link to terms of use: https://data.humdata.org/faqs/licenses. | PMC10058159 | pntd.0011166.g008.jpg |
0.502016 | 7a3c5ee22f664fadb29c7baa419557a9 | Priority sub-counties in Turkana County based on a combination of Epidemiological and WASH indicators, 2015–2019.Link to base map layer: https://data.humdata.org/dataset/cod-ab-ken Link to terms of use: https://data.humdata.org/faqs/licenses. | PMC10058159 | pntd.0011166.g009.jpg |
0.48888 | 6ad8e04411764cbeb1277cdcb4990f67 | Priority sub-counties in Garissa County based on a combination of Epidemiological and WASH indicators, 2015- 2019.Link to base map layer: https://data.humdata.org/dataset/cod-ab-ken Link to terms of use: https://data.humdata.org/faqs/licenses. | PMC10058159 | pntd.0011166.g010.jpg |
0.495189 | 562ebaa80bc440ee96298a3bd46d5a41 | Effects of lipopolysaccharide (LPS) on inflammatory responses. mRNA expression of inflammation markers in primary chondrocytes (a) and C28/I2 chondrocytes (b) significantly increased 6 h after LPS stimulation. Data from cells treated with LPS (dashed pattern) were compared to appropriate control and obtained from the same set of samples (n = 13 to 15 different primary chondrocyte cultures or n = 5 for C28/I2). Quantification of expression levels was calculated for each target gene and normalized using the reference housekeeping gene GAPDH. Values obtained in chondrocytes were calculated according to the formula 2−ΔCt and expressed as number of molecules per 100,000 GAPDH molecules. Results are means ± SEM. Statistical analysis was performed by Student’s t test for paired samples (* p < 0.05; ** p < 0.01; and *** p < 0.001). | PMC10058228 | ijms-24-05830-g001.jpg |
0.423334 | 2288d3c8dd0d49fcb0fd3d356af8c7fe | Antioxidant effect of OE and HT in C28/I2 chondrocytes. (a) LPS treatment increases ROS production progressively from time 2 h to 120 h compared to control. ROS were assessed by fluorescence intensity of DCHF-DA. (b) Pretreatment of C28/I2 chondrocytes with olive-derived nutraceuticals OE and HT showed a statistically significant reduction in LPS-induced oxidative stress at 48 h. Data represent results from multiple analysis (n = 4) of quadruplicate samples for each experimental condition expressed as mean ± SEM and normalized with respect to the control at 48 h. Statistical analysis was performed by ANOVA, followed by Newman–Keuls’ post hoc test, with ** p < 0.01. | PMC10058228 | ijms-24-05830-g002.jpg |
0.402718 | 347b1b4c3ffa441396fa0b362252fefc | Effects of OE and HT on inflammatory markers. LPS treatment increases markers of OA in primary OA chondrocytes and pretreatment with either OE (upper graphs) or HT (lower graphs) efficiently inhibits this effect. Results are means ± SEM (n = 5 to 9 different primary chondrocyte cultures), normalized using the reference housekeeping gene GAPDH according to the formula 2−ΔCt and expressed as number of molecules per 100,000 GAPDH molecules. Statistical analysis was performed by ANOVA, followed by Newman–Keuls’ post hoc test, with ** p < 0.01, *** p < 0.001. | PMC10058228 | ijms-24-05830-g003.jpg |
0.397209 | c45e1f82a7384977b210708247014753 | Effects of OE and HT on relevant intermediates of signaling pathways, and on the pivotal catabolic enzyme in OA. LPS treatment increases the expression of these genes in primary OA chondrocytes and pretreatment with either OE (upper row) or HT (lower row) efficiently inhibits this effect. Results are means ± SEM (n = 4 to 9 different primary chondrocyte cultures), normalized using the reference housekeeping gene GAPDH according to the formula 2−ΔCt and expressed as number of molecules per 100,000 GAPDH molecules. Statistical analysis was performed by ANOVA, followed by Newman–Keuls’ post hoc test, with * p < 0.05, ** p < 0.01, *** p < 0.001. ns = not significant. | PMC10058228 | ijms-24-05830-g004.jpg |
0.46212 | 31746dcc4b92456c81300c18fc9bb963 | Left: activation of JNK by LPS exposure in primary OA chondrocytes. To account for the different solubility requirements of the two polyphenols, two different set of samples were prepared, with either DMSO as a vehicle (to assess OE effects) or ethanol (to assess HT effects). Right graph: quantification of phosphorylated JNK intensity relative to β-actin, and expressed as fold change relative to the control for each set of samples. Stimulation with LPS increased the levels of phosphorylated JNK while pretreatment with either OE or HT prevented this activation. | PMC10058228 | ijms-24-05830-g005.jpg |
0.490348 | 14985f3b192d4a2cb13276458a8357a6 | Activation of JNK pathway (phosphorylation of JNK and c-Jun) and of NOTCH1 (cleavage of Val1744) following LPS exposure and their effects on MMP-13 transcription. (a) In C28/I2, stimulation with LPS (1 h) strongly increased the levels of phosphorylated JNK and, after 6 h, that of cleaved NOTCH1. DAPT-mediated inhibition of NOTCH1 cleavage (Val1744) and activation enhances phosphorylated JNK after LPS exposure. Representative Western blots are shown for P-JNK (n = 4), P-c-Jun (n = 7) and NOTCH1 Val1744 (n = 3) In the latter case, rearrangement (switch) of LPS and DAPT lanes was performed for consistency with the other Western blots (see Supporting information file). (b) MMP-13 mRNA (6 h) showed a trend that was found in correlation with that of phosphorylated JNK (1 h). Statistical analysis was performed by ANOVA, followed by Newman-Keuls’ post hoc test, with * p < 0.05, ** p < 0.01, *** p < 0.001. ns = not significant. | PMC10058228 | ijms-24-05830-g006.jpg |
0.428922 | 5a03f24e4723484b9fd4d06d8bc6bd75 | Inhibiting effects of OE and HT on LPS-induced MMP-13 expression in C28/I2 chondrocytes, following 6 h exposure to LPS. Right graph: quantification of MMP-13 intensity relative to β-actin (2 experiments). | PMC10058228 | ijms-24-05830-g007.jpg |
0.496452 | 2df52d698aed4ed7bfeafc18a968ee2d | Inhibiting effects of OE and HT pretreatment on LPS-induced MMP-13 release from OA chondrocytes, following 24 h exposure. Cumulative data obtained from three patients (mean ± SEM, n = 3), with triplicate wells seeded for each condition for each patient. Oleuropein was confirmed as exhibiting a complete inhibiting activity on MMP-13 release induced by LPS treatment. Data were compared by ANOVA, followed by Newman–Keuls’, with ** p < 0.01, *** p < 0.001. | PMC10058228 | ijms-24-05830-g008.jpg |
0.479842 | 94aa75a888ad4e1fbb122d73405dad21 | Intraoperative 0° telescopic images of patient “C”: (A) View through vocal folds with stenosis apex 16 mm from the superior surface of the vocal fold with anterior extent just inferior to Broyles ligament. (B) Following KTP ablation and balloon dilation to 15 mm. (C) Post-dilation view of 1.5 cm length stenosis and laser tube below. (D) After placement of a 13 mm diameter T-tube with a proximal limb of 11 mm. | PMC10058324 | life-13-00740-g001.jpg |
0.409474 | 5c76350154d343799c7ef1af8045a853 | Preoperative coronal (A), sagittal (B), and axial (C) images of patient “A”. Note diffuse sclerosis and destruction of the posterior cricoid plate. | PMC10058324 | life-13-00740-g002.jpg |
0.438764 | 24850251288a47c9a9a2291ce0166247 | Bronchoscopic images of patient “E”. (A) Initial flexible bronchoscopy showing complete fusion and occlusion of the subglottic space. (B) Intraoperative image postrecannulation of tracheal stenosis. (C) Flexible bronchoscopy at the 2-week follow-up with T-tube in place. (D) Flexible bronchoscopy after T-tube decannulation with marked improvement of tracheal stenosis. | PMC10058324 | life-13-00740-g003.jpg |
0.418311 | 0c9f706e356b40d38c4cdf5e3ecb63bf | (a) A schematic depiction of the “parent”, a single spherical vesicle with the fixed radius R0, area A0, and volume V0 (the parent state), converting to (b) the “progeny” spherical vesicle with the fixed radius R1, area A1, and volume V1, including n daughter spherical vesicles with the fixed radius Rd, area Ad, and volume Vd (the progeny state). | PMC10058475 | membranes-13-00332-g001.jpg |
0.542903 | 673218f7ffac47fe98134a88b79cfd0b | The final vesicle size R1 as a function of the initial size R0. The light yellow color indicates a stable regime for ΔF<0. The blue solid line, the red dashed line, and the green dash-dotted line corresponds to γsp=7.05×10−6mN/m, 7.01×10−6mN/m, and 6.97×10−6mN/m, respectively, within the spontaneous tension range in Table 1 of [7]. | PMC10058475 | membranes-13-00332-g002.jpg |
0.466606 | cd7de6fa5cb74003a2e8ac8e1d39069d | The number of daughter vesicles as a function of the initial size R0. The black dots with the error bars are calculated from the experimental data of [3]. The light yellow color indicates the stable regime for ΔF<0. The blue solid line, the red dashed line, and the green dash-dotted line corresponds to γsp=7.05×10−6mN/m, 7.01×10−6mN/m, and 6.97×10−6mN/m, respectively, within the spontaneous tension range in Table 1 of [7]. | PMC10058475 | membranes-13-00332-g003.jpg |
0.532114 | b726f61343404c5fb225f69c3a151735 | Vestigial osmotic pressure as a function of the initial size R0. The vestigial osmotic pressure, according to the experiments in [2], was estimated to be 0.4 mPa, which is marked by a magenta arrow. The light yellow color indicates a stable regime for ΔF<0. The blue solid line, the red dashed line, and the green dash-dotted line corresponds to γsp=7.05×10−6mN/m, 7.01×10−6mN/m, and 6.97×10−6mN/m, respectively, within the spontaneous tension range in Table 1 of [7]. | PMC10058475 | membranes-13-00332-g004.jpg |
0.406829 | d3180b4a604c49dc8438803cda16616b | Distribution of eigenvalues after normalization. ((a) Snapshots = 10; (b) Snapshots = 100; (c) Snapshots = 200). | PMC10058653 | sensors-23-03100-g001.jpg |
0.522302 | 0ebf8c32d71e44faadae8af62319d39b | The structure of the CNN model. | PMC10058653 | sensors-23-03100-g002.jpg |
0.490003 | 4710d94cd5e7414790a6c63975a62bef | Illustration of the dropout method. ((a) Structure with = out Dropout; (b) Structure with Dropout). | PMC10058653 | sensors-23-03100-g003.jpg |
0.445471 | 63c79001860948f4a3ca07efb30c34ff | Comparison of RMSE of various algorithms with different SNRs. | PMC10058653 | sensors-23-03100-g004.jpg |
0.476633 | cf38ae03f36c45f08cccd925d6f7932c | Comparison of RMSE of various algorithms with different snapshots. | PMC10058653 | sensors-23-03100-g005.jpg |
0.516811 | 65af6c6c41ee4d0598a87f5863f636bc | Performance of CNN algorithms for source number and DOA estimation at low snapshot and low SNR. | PMC10058653 | sensors-23-03100-g006a.jpg |
0.416975 | d211a1300aff4cf584d2a825d6557b6f | Triterpenoids quantified in apple fruits and leaves. | PMC10058748 | molecules-28-02584-g001.jpg |
0.434899 | faf2c95ce66f461ba6d4dc19e9e4bf76 | The changes in the triterpenoid content in fruits per unit area during the growth of three apple cultivars. Numbers on the horizontal axis denote the collection dates. | PMC10058748 | molecules-28-02584-g002.jpg |
0.411551 | 9f2beaea4171432ebe2ecefa868b74c2 | The changes in the triterpenoid content in leaves per unit area during the growth of three apple cultivars. Numbers on the horizontal axis denote the collection dates. | PMC10058748 | molecules-28-02584-g003.jpg |
0.515208 | 6c5b121d1aa847a68e895e73131e1b1c | The contribution of the triterpenoids to the total antioxidative and anti-inflammatory activities of apple extracts. The activity of the apple extracts was compared with the theoretical activity of their selected constituents. | PMC10058748 | molecules-28-02584-g004.jpg |
0.444016 | 5d250433f77445988110f170509ac087 | Historical overview of Parkinson’s disease research. Schematic representation of some of the most relevant findings in PD research from its discovery to treatment development. | PMC10059018 | pharmaceutics-15-00839-g001.jpg |
0.416994 | 842cbbf817e34a9eaf1a185148982fad | Symptomatic progression of PD. Schematic overview of both, MS and NMS symptoms progression and variability. PD diagnosis is based in MS, but NMS usually appears years before MS could be appreciated during the prodromal stage. The severity of the symptoms results from a combination of NMS, MS, and L-DOPA-derived complications. | PMC10059018 | pharmaceutics-15-00839-g002.jpg |
0.455422 | 4c7c3a595e2c4a97a69fcd66e55d3c28 | Molecular mechanism of Parkinson’s disease cell damage. Schematic representation of the interconnected molecular processes that induce cell death and PD progression. Adapted from [61]. | PMC10059018 | pharmaceutics-15-00839-g003.jpg |
0.458851 | b07db21c0fec465793aa3311ddd0196d | Alpha synuclein architecture. (A) Schematic representation of α-Syn primary sequence indicating the location of positively (blue) and negatively (red) charged amino acid, and KTKEGV repeats (green). Sequential domains and single-point mutations related to familial cases of PD are also indicated below the linear representation. (B–D) Structure of monomeric (B) and aggregated α-Syn forming different conformations or strains (C,D). In (B–D), the PDB files used are: 1XQ8, 6CU7, and 6CU8, respectively. | PMC10059018 | pharmaceutics-15-00839-g004.jpg |
0.444235 | 59200af4162344da9768588cd766b7d0 | Schematic α-Syn aggregation profile. The aggregation kinetics of most of the proteins can be dissected into three main phases (blue). This also applies to α-Syn, for which the first step (nucleation or lag phase) is characterised by the formation of small nucleus that would guide the process; these nuclei incorporate monomeric protein prompting an exponential growth of the aggregate (elongation or exponential phase); finally, the system enters in an equilibrium in which mature fibrils could be observed (saturation or plateau phase). However, the process could be accelerated (red) as fibrils can fragment into smaller aggregates that can be incorporated at the initial stages as nuclei or seeds (seeding). | PMC10059018 | pharmaceutics-15-00839-g005.jpg |
0.444714 | 76be0034da374c479ec95a3415e0f675 | Inhibiting α-Syn aggregation. Schematic representation of the different mechanisms, illustrated by coloured symbols, available to prevent the aggregation of α-Syn, which follows a slow process that comprises different assemblies of the protein: monomeric (A), oligomeric (B), and fibrillar (C), or amorphous (D) aggregates. This process comprises different steps during the development of PD: protein–lipid interaction (1), oligomerization (2), fibril elongation (3), secondary nucleation (4), transmission (5), seeding (6), and amorphous aggregation (7). | PMC10059018 | pharmaceutics-15-00839-g006.jpg |
0.419493 | 481d9ba9fb064daa80f97e9e672cfeda | Chemical structures of inhibitors of α-Syn aggregation. Molecular structures of the most relevant modulators grouped by molecular class and mechanism of action. Abbreviations: EGCG, epigallocatechin-3-gallate; LMTM, leuco-methylthioninium bis(hydromethanesulphonate). | PMC10059018 | pharmaceutics-15-00839-g007.jpg |
0.465518 | 7b9c5cac2c8a4625957e25c0d66a558a | Genetic organization of the immigration control region (ICR) in six Listeria monocytogenes strains. Conserved boundaries of the ICR are indicated with black arrows and with gray connections. Arrows are color-coded based on gene annotations, which are provided in the key. Genomes were selected in order to visualize the most abundant and diverse content found in the ICR. Gene names above F2365 (e.g., LMOf2365_0322) and EGD-e (e.g., lmo0301) denote RefSeq locus tags for these reference L. monocytogenes strains. | PMC10059834 | microorganisms-11-00699-g001.jpg |
0.403938 | 0b7bea75bf3a49ceac4bbda6c508995a | Distribution of restriction modification systems harbored in the immigration control region (ICR) located between lmo0301 and lmo0305 homologs among whole-genome sequenced L. monocytogenes strains. Distributions are shown by (A) serotype or lineage and (B) source. “Other” ICR content includes miscellaneous genomic islands and genes (e.g., DNA helicase genes) while “none” indicates no novel gene content, typically a lipoprotein and small hypothetical proteins. “Lin III/IV” indicates strains of Lineage III or IV (Table S1) for which accurate serotype designations are lacking. “Clinical” indicates strains of human clinical origin, while “Animal” includes strains from animal listeriosis as well as from wildlife, i.e., black bears (Table S1). A single strain (OLM81) has no known source and was excluded from panel B. | PMC10059834 | microorganisms-11-00699-g002a.jpg |
0.47585 | e428d623a84248e5b5ee592c2a2c888f | Distribution of restriction modification systems in the ICR in strains of diverse STs. Minimum spanning tree (MST) was constructed with the seven-locus MLST scheme using BioNumerics 8.1 as described in Materials and Methods. Each circle corresponds to a single sequence type (ST) and the circle size correlates to the number of strains in the respective ST; numbers next to circles denote relevant STs (e.g., 1, 2, 388, 1039). The smallest circles include one genome while the largest circle includes 50 genomes. STs are separated by branches based on seven-locus MLST similarity: one-allele difference (thick black line), two-allele differences (thin gray solid line), three-allele differences (dashed line), four-allele differences (dotted line), more than four-allele differences (thin dotted line). STs are color-coded based upon (A) serotype or lineage and (B) ICR content, specifically the harbored type of RM system(s). “Other” ICR content includes miscellaneous genomic islands and genes (e.g., DNA helicase genes), while “none” indicates no novel gene content, typically a lipoprotein and small hypothetical proteins. | PMC10059834 | microorganisms-11-00699-g003a.jpg |
0.428628 | 8ceedef8c24243e3be7a726d2eeafbd9 | Diglycosidases and exoglycosidases: substrates and cleavage sites. | PMC10059904 | ijms-24-05943-g001.jpg |
0.418127 | b63bd30f61804fd096885ef7f359da0d | Acuminosylation of tyrosol by Aromase H2. | PMC10059904 | ijms-24-05943-g002.jpg |
0.565027 | 395627abba834de68c10e92d6ee92fe6 | Products of transglycosylations of tyrosol from pNP vicianoside and pNP primeveroside catalyzed by Aromase H2. Line 1: standard of pNP vicianoside. Line 2: reaction of pNP vicianoside with tyrosol. Line 3: standard of salidroside. Line 4: reaction of pNP primeveroside with tyrosol. Line 5: standard of pNP primeveroside. | PMC10059904 | ijms-24-05943-g003.jpg |
0.381743 | 3fb3b8e36db8432f81494341f425625c | Visual Analogue/Likert Scores of Symptoms. | PMC10059925 | medicina-59-00571-g001.jpg |
0.431389 | 8efbeffd3d894796a23ecbc14fefcc33 | Mean score of all nine domains of the SSS instrument—ME/CFS subjects only. The shaded area represents the 95% confidence interval. Note that there are a significant number of data points beyond day 10, representing about 7–8% of ME/CFS subjects. Each dot is the mean SSS score for an individual ME/CFS subject; Blue line is the spline curve representing the average of all data points in the figure; Light blue area is the 95% confidence interval. | PMC10059925 | medicina-59-00571-g002.jpg |
0.451757 | ad4a6cc0248a40d1a6b9ad97868d1d46 | Post-Exertional Malaise (PEM) domain score of SSS instrument—ME/CFS vs. CTL. The shaded area represents the 95% confidence interval. Each dot represents the PEM score for a single subject; Blue dots are low scores, red dots are high scores; Black lines represent the spline curves for group averages; Grey shaded areas are the 95% confidence intervals. | PMC10059925 | medicina-59-00571-g003.jpg |
0.434748 | bbea4ed61a51415699c3b38d3acd6d98 | Fatigue domain score of SSS instrument—ME/CFS vs. CTL. Shaded area represents the 95% confidence interval. Each dot represents the PEM score for a single subject; Blue dots are low scores, red dots are high scores; Black lines represent the spline curves for group averages; Grey shaded areas are the 95% confidence intervals. | PMC10059925 | medicina-59-00571-g004.jpg |
0.465557 | 690c18581d25436eb80b07237dcf4d1c | PEM domain score of SSS instrument by study site—ME/CFS vs. CTL. Fatigue domains score of SSS instrument—ME/CFS vs. CTL. Each dot represents the PEM score for a single subject; Blue dots are low scores, red dots are high scores; Black lines represent the spline curves for group averages; Grey shaded areas are the 95% confidence intervals. | PMC10059925 | medicina-59-00571-g005.jpg |
0.46051 | dcb85a73c273444abd76ffb3d47c2fe9 | Post-Exertional Malaise (PEM) Recovery by Level of Baseline Symptoms. PEM domain scores of the SSS instrument by the severity of pre-test symptoms: High, Intermediate (Int) or Low—ME/CFS only. Each dot is the mean PEM score for an individual ME/CFS subject; Blue lines are the spline curves representing the average of all data points in each subgroup; Light blue areas are the 95% confidence intervals. | PMC10059925 | medicina-59-00571-g006.jpg |
0.442808 | 1314ce75cc0948988e7490b47ec646b8 | Oral Dose Pharmacokinetic Model of PEM Response to 2-day CPET. Oral dose pharmacokinetic model of mean SSS score. Pre-test scores were normalized to 0, and on subsequent survey days, all mean SSS scores ≤ 0 were set to 0 as representing full recovery from the 2-day CPET. F ratio = 8.41, p < 0.0005. Black box represents that in this model all subject’s Mean SSS scores were normalized (set to 0 at time 0, or pre-CPET1, for all subjects); Black dots are all other normalized Mean SSS scores for each subject, at subsequent days; Green line is the mathematical solution for the model. | PMC10059925 | medicina-59-00571-g007.jpg |
0.470498 | b50b71a376f84003b9af27fee3df0fe0 | Four Parameter Pharmacokinetic Model of PEM Response to 2-day CPET. Four-parameter pharmacokinetic model of normalized mean SSS scores. Scores were adjusted for pre-test symptoms, such that all pre-test values were 2.45 (open box at day 0). Black box represents that in this model all subject’s Mean SSS scores were normalized (set to 2.45 at time 0, or pre-CPET1, for all subjects); Black dots are all other normalized Mean SSS scores for each subject, at subsequent days; Green line is the mathematical solution for the model. | PMC10059925 | medicina-59-00571-g008.jpg |
0.522561 | 7d968b9e6dde42bfab32be515022fcba | One-Dose Pharmacokinetic Model by Pre-CPET 1 Symptoms. One dose pharmacokinetic model by pre-CPET1 symptoms—ME/CFS only. High, Intermediate (Int) and Low groups were assigned by their pre-CPET1 mean SSS scores; High and low were the highest and lowest quartiles, Int was the middle two quartiles. Intermediate and high groups were not significantly different from the low group: High group vs. Int, F ratio = 0.05, N.S.; Low, F ratio = 0.01, N.S.; Int group vs. Low: F ratio = −0.04, N.S. Black boxes represent that in this model all subject’s Mean SSS scores were normalized (set to 0 at time 0, or pre-CPET1, for all subjects); Black dots are all other normalized Mean SSS scores for each subject, at subsequent days; Red, green and blue lines are the mathematical solutions for each group in the model. | PMC10059925 | medicina-59-00571-g009.jpg |
0.437026 | 5aca58e14b57495c9d770450cc859f26 | Images from the sample of the present study taken using 3D Slicer software. A: Computed tomography shows the maxillary sinus in an axial slice. B: Computed tomography shows the maxillary sinus in a sagittal slice. C: Computed tomography shows the maxillary sinus in a frontal slice. D: 3D reconstruction presents the right maxillary sinus in blue and the left maxillary sinus in red. | PMC10060761 | isd-53-53-g001.jpg |
0.477287 | 866768d19c804f9ba8f1b05b58ebf215 | An image from the sample of the present study taken using the 3D Slicer software for maxillary sinus computed tomography with 3D reconstruction shows the right maxillary sinus in blue and the left maxillary sinus in red. | PMC10060761 | isd-53-53-g002.jpg |
0.470078 | 4ada1d6a447b4d13bc69b22058b9a0f8 | Functional And Tractographic Analysis Toolbox-awFC pipeline. This is a two-stage pipeline and when combined, results in a more straightforward approach for combining fMRI and DTI data. The first stage is the “Functional and Tractographic Connectivity Analysis Toolbox” (FATCAT) pipeline. The outputs include functional connectivity (derived from fMRI) and the number of tracts (derived from DTI). The second stage of the pipeline is known as the anatomically weighted functional connectivity (awFC), which processes the output of FATCAT to produce the anatomically weighted functional connectivity measure (awFC measure). fMRI, functional magnetic resonance imaging; DTI, diffusion tensor imaging; DT, diffusion tensor; ICA, independent component analysis; ROIs, regions of interest; SC, structural connectivity; FC, functional connectivity; awFd, anatomically weighted functional dissimilarity; awFC, anatomically weighted functional connectivity; set of AFNI commands (3dMatch, 3dROIMaker, 3dNetCorr, 3dDWItoDT, 3dDWUncert, and 3dTrackID). | PMC10060836 | fnins-17-1066373-g001.jpg |
0.357865 | bfb554b2262a4950b48900d297db71be | Statistically significant anatomically weighted functional connectivity group differences between brain regions are displayed for each network. Isolated brain regions were defined using the FATCAT command 3dROIMaker. Each color represents a different ROI for each network (A) DMN, green ROI, posterior cingulate cortex, red ROI, left angular gyrus (B) FPN, blue ROI, left inferior frontal gyrus, orange ROI, right superior frontal gyrus, green ROI, lingual gyrus/cerebellum (C) LIM, yellow ROI, right superior temporal gyrus, red ROI, left superior temporal gyrus (D) VAN, yellow ROI, right anterior orbitofrontal gyrus, blue ROI, left lingual gyrus/cuneus (E) DAN, yellow ROI, right posterior orbitofrontal gyrus, red ROI, left inferior temporal gyrus. ROI, region of interest; DMN, default mode network; FPN, frontoparietal network; VAN, ventral attention network; DAN, dorsal attention network. Anatomical positions, A, anterior view; P, posterior view; S, superior view; I, inferior view; L, left view’ R, right view. | PMC10060836 | fnins-17-1066373-g002.jpg |
0.417954 | 704c2d6fa1224f7f9b9d693cee0f83b1 | Boxplots demonstrate the anatomically weighted functional connectivity strength in children of mothers with a high adversity score (orange boxes) compared to children of mothers with a lower adversity score (blue boxes). Significant differences between HA and HC are shown within the (A) DMN between the PCC and L-AG (B) FPN between the L-IFG and the LG/CER (C) FPN between the R-SFG and the LG/CER (D) LIM between the R-STG and the L-STG (E) VAN between the R-aOFG and L-LG (F) DAN between the R-pOFG and L-ITG. adversity, children exposed to maternal adversity, control, healthy control group, The asterisks indicate a statistically significant difference in the ROI awFC between groups at *p < 0.05 and **p < 0.01. DMN, default mode network; FPN, frontoparietal network; LIM, limbic network; VAN, ventral attention network; DAN, dorsal attention network; L, left; R, right; IFG, inferior frontal gyrus; LG/CER, lingual gyrus/cerebellum; SFG, superior frontal gyrus; STG, superior temporal gyrus; aOFG, anterior orbitofrontal gyrus; LG, lingual gyrus; pOFG, posterior orbitofrontal gyrus; ITG, inferior temporal gyrus. | PMC10060836 | fnins-17-1066373-g003.jpg |
0.379079 | 90b1c8c4b00f4bf2986b6b04cc846dd7 | Distribution of type of referring expression of the critical pronoun's antecedent. Distribution of d-pronoun's antecedent on the (Left), distribution of personal pronoun's antecedent on the (Right). | PMC10060885 | frai-06-1058554-g0001.jpg |
0.415677 | 2d3f2cca18ef435183d2d6fd03a851c1 | Distribution of grammatical role (Left) and thematical role (Right) of the antecedents of the personal pronouns (red, n = 181) and d-pronouns (blue, n = 36). | PMC10060885 | frai-06-1058554-g0002.jpg |
0.46165 | 616ec2163c9c4965bd3a4b281db25f9a | Presentation scheme. The total duration of the protocol was ~1 h. The audio book was presented in 9 consecutive parts with an average duration of 6:26 min per chapter. After each chapter, two comprehension questions were presented. | PMC10060885 | frai-06-1058554-g0003.jpg |
0.507662 | c193e98cd83a48c2bae5322e2833b74c | Grand-average ERPs for d-pronouns (blue) and personal pronouns (red) averaged for nine regions of interest. The vertical line indicates the onset of the pronouns. Negativity is plotted up. | PMC10060885 | frai-06-1058554-g0004.jpg |
0.40377 | 04841a19a1134e0889d15fc1197eaeff | Grand-average ERPs of d-pronouns comparing three perspective takers: Maik/narrator (dark blue, dotdashed line), Tschick (blue, dashed line), and father (light blue, solid line). The vertical line indicates stimulus onset. | PMC10060885 | frai-06-1058554-g0005.jpg |
0.512527 | 51788413acd14a78b34b67abbef228dc | Microbial alpha diversity indices. The ecological diversity of microbiota in transitional stools of newborns (36-72h after birth), virginal fluids (before delivery) and stool of mothers (the last excretion before delivery) was measured by Sobs (A), Pielou evenness index (B), the Simpson index (C), and the Shannon index (D). The P values were conducted by Welch’s t test. Statistical significance is displayed as *P<0.05 and **P<0.01. Sobs, Observed species; TSC, Transitional stools of caesarean delivered neonates; I, Transitional stools of caesarean delivered neonates with the treatment of swabbing maternal vaginal fluid; TSN, Transitional stools of natural delivered neonates; V, Vaginal fluids of the pregnant women who underwent caesarean delivery; VN, Vaginal fluids of the pregnant women who underwent natural delivery; F, Feces of the pregnant women who underwent caesarean delivery; FN, Feces of the women who underwent natural delivery. Symbol "*" was presented above each plot. | PMC10061231 | fcimb-13-1065884-g001.jpg |
0.410577 | 7dfad695585545cc835bdc72ae7cda98 | Visualization of beta-diversity index (A), PcoA (B), and NMDS (C). These plots were conducted basing on Bray-Curtis Distance. Each dot represents one sample. In (A), mean beta-diversity (distance from centroid) ± standard error.Statistical significance is displayed as *P < 0.05 and **P < 0.01. TSC, Transitional stools of caesarean delivered neonates; I, Transitional stools of caesarean delivered neonates with the treatment of swabbing maternal vaginal fluid intervention; TSN, Transitional stools of natural delivered neonates; VN, Vaginal fluids of the pregnant women who underwent natural delivery; V, Vaginal fluids of the pregnant women who underwent caesarean delivery; FN, Feces of the women who underwent natural delivery; F, Feces of the pregnant women who underwent caesarean delivery. | PMC10061231 | fcimb-13-1065884-g002.jpg |
0.465149 | 6878aaa2efff493b918bbc342c07761f | Taxa distribution plots at phylum and genus level. The relative abundances of microbial communities at genus level. TSC, Transitional stools of caesarean delivered neonates; I, Transitional stools of caesarean delivered neonates with the treatment of swabbing maternal vaginal fluid intervention; TSN, Transitional stools of natural delivered neonates; VN, Vaginal fluids of the pregnant women who underwent natural delivery; V, Vaginal fluids of the pregnant women who underwent caesarean delivery; FN, Feces of the women who underwent natural delivery; F, Feces of the pregnant women who underwent caesarean delivery. | PMC10061231 | fcimb-13-1065884-g003.jpg |
0.443328 | 6e960838d5684087ab06662359b80f46 | The Effect Analyses of Swabbing Exposure. The characteristic taxa were measured by indicator analysis (A) and ternary plot (B). The P values were conducted by Tukey HSD test. Statistical significance is displayed as *P < 0.05 and **P < 0.01. TSC, Transitional stools of caesarean delivered neonates; I, Transitional stools of caesarean delivered neonates with the treatment of swabbing maternal vaginal fluid intervention; TSN, Transitional stools of natural delivered neonates; VN, Vaginal fluids of the pregnant women who underwent natural delivery; V, Vaginal fluids of the pregnant women who underwent caesarean delivery; FN, Feces of the women who underwent natural delivery; F, Feces of the pregnant women who underwent caesarean delivery. | PMC10061231 | fcimb-13-1065884-g004.jpg |
0.552523 | 638bf111cd804ec0b8399b6a50261156 | VENN diagrams at genus level. VENN diagram was used to represented the common and unique genera among different groups. TSC, Transitional stools of caesarean delivered neonates; I, Transitional stools of caesarean delivered neonates with the treatment of swabbing maternal vaginal fluid; V, Vaginal fluids of the pregnant women who underwent caesarean delivery. | PMC10061231 | fcimb-13-1065884-g005.jpg |
0.448285 | 2b3c8c7209e3495096563df18ae4e3a0 | Pathogenic mechanisms of Long COVID | PMC10061411 | 296_2023_5319_Fig1_HTML.jpg |
0.439199 | 60d2345c91b746f6ba0b06d5d4401f79 | Potential risks (red label) caused by the improper site
selection
of UCG: 1—forming water flowing fissures; 2—roof cracks
connecting the UCG cavity with the surface; 3—poor gasification
characteristics of raw coal; 4—large-area roof collapse; 5—discontinuity
of the coal seam; 6—instability of seam occurrence. | PMC10061594 | ao3c00626_0002.jpg |
0.40992 | b286ca28cdde493c885d07ce442f410a | Relationship
between coal resource conditions and potential risks
of UCG. | PMC10061594 | ao3c00626_0003.jpg |
0.469848 | 57954465534743c4beb3f92f23cc3a9c | Evaluation modeling flowchart of the UCG site selection. | PMC10061594 | ao3c00626_0004.jpg |
0.517209 | 073464620c9d4ab983b03b11dc79b641 | Comparison of weights
determined by the subjective, objective,
and combined weighting methods. | PMC10061594 | ao3c00626_0005.jpg |
0.503591 | 78c5da8010534659bc6288442d6ae815 | Evaluate results of the resource condition suitability on UCG of
Zhongliangshan (ZLS), Huating (HT), and Shanjiaoshu (SJS) pilot project. | PMC10061594 | ao3c00626_0006.jpg |
0.41013 | bc4e74d382a042c9b5a633ab706fb1f9 | Median days from HIV diagnosis to initiating ART among PLWH in total sample and subgroups in Beijing, 2010–2020. (A) Median days from HIV diagnosis to initiating ART among PLWH in Beijing 2010–2020. (B) Median days from HIV diagnosis to initiating ART among PLWH in Beijing by sex, 2010–2020. (C) Median days from HIV diagnosis to initiating ART among PLWH in Beijing by age, 2010–2020. (D) Median days from HIV diagnosis to initiating ART among PLWH in Beijing by route of infection, 2010–2020. | PMC10061757 | ccdcw-5-6-131-1.jpg |
0.475392 | f155078d6f7d406abde6961d6852a044 | Proportion of CD4+ cell counts (stratified) among PLWH at initial treatment in Beijing, 2010–2020. | PMC10061757 | ccdcw-5-6-131-2.jpg |
0.441814 | ddc88d9814804edb995dfc3e3f67ccd8 | Trend of top five most commonly prescribed initial ART regimens for each year among PLWH in Beijing, 2010–2020. | PMC10061757 | ccdcw-5-6-131-3.jpg |
0.441072 | b5bd7c54d0744847a033a039546ac8a0 | Linear regression between birth weight and obesity and diabetes genes including (a) MTNR1B, (b) NTRK2, (c) PCSK1, (d) PTEN, (e) PPAR a | PMC10061768 | 12884_2023_5538_Fig3_HTML.jpg |
0.410822 | 9256110657044038a74f535c1e19e2ca | Trend in PHI coverage against expenditures for Zimbabwe: 1980–2016. Sources: Segall (1983), Manga (1988), Normand et al. (1996), Shamu et al. (2010), Zimbabwe NHAs (2010, 2015), Zimbabwe National Health Financing Strategy (2017) | PMC10061904 | 12939_2023_1868_Fig1_HTML.jpg |
0.490272 | 1133b3680ebf44628df7045bd38c8152 | Slit-lamp image showing a tick adherent to the medial canthus of the right eye | PMC10062064 | OJO-16-175-g001.jpg |
0.411718 | 25fdfd8ad9974e618bee3c860f7e54a6 | Magnified slit-lamp image showing: A – markings on the body of the tick. B – the legs of the tick underneath its body | PMC10062064 | OJO-16-175-g002.jpg |
0.370286 | 1fc4362a07484082841dad370eadde3a | Slit-lamp image showing an area of excoriation in the eyelid, after removal of the adherent tick | PMC10062064 | OJO-16-175-g003.jpg |
0.408621 | e76772d872c447f69b20d89681a67483 | Slit-lamp image showing an area of excoriation and bleeding in the eyelid, after removal of the adherent tick | PMC10062064 | OJO-16-175-g004.jpg |
0.38524 | 1638e56488234ca59befeae3a35c465a | Herbicide effects on invasive annual vegetation.Density, per square meter, of living invasive annual grasses (IAG, top) and forbs (IAF, bottom) by seeding year (across the bottom) and experimental site (across the top) late in the first growing season (May-Jun) after application of pre-emergent herbicide the previous fall (Sep-Nov), in areas that received the herbicide (light gray) compared to those that did not (dark gray). Rate of herbicide application was 584 ml/ha (8 oz/ac) formula of Plateau (137 ml/ha AI imazapic) in the 2018 seeding year, and 730 ml/ha (10 oz/ac) formula (172 ml/ha AI) in the remaining years. Black stars indicate significant difference among the herbicide treatments. Error bars are standard errors. Note differences in scale for each year. | PMC10062626 | pone.0283678.g001.jpg |
0.463569 | 8a69230b1cbb461f8f9d03e058697b7f | Herbicide effects on bare seed treatment.Observed differences in late season seedling count and seedling size from bare, unprotected seed sown in the presence (light gray) and absence (dark gray) of pre-emergent herbicide applied immediately after sowing, by site and across species in seeding year 2018 (panel A) and 2019 (panel B), and by site and species in seeding year 2020 (panel C). Only data from the shallow furrow delivery method are shown. Black stars indicate significant difference among the herbicide treatments (P < 0.05), with arrows added in panel B to indicate herbicide effects that were regardless of seeded species identity. Error bars are standard errors. | PMC10062626 | pone.0283678.g002.jpg |
0.410261 | 3aab73cdd9f644ac9d3907995a7b1f7d | Comparison of HP seed treatments.Observed differences among HP seed treatments (pellets, coatings, HP band) in both early and late season seedling count (as a percent of viable seed sown), in 2018 (panel A) by seeding site, species and herbicide treatment (H = herbicide, NH = no herbicide), in 2019 for grasses (panel B) by herbicide treatment, and in 2019 for sagebrush (ARTR, panel C) by site. Refer to Fig 4 for significant differences among HP seed treatments in 2020. All data shown used the shallow furrow delivery method, with all broadcast delivery data removed from the two years it was used (2018, 2019). Black stars indicate significant difference among the HP seed treatments (P < 0.05). Error bars are standard errors. | PMC10062626 | pone.0283678.g003.jpg |
0.432422 | 81849922541b4c9ebdcc37f04fa0f070 | Comparison of HP and bare seed treatments.Observed differences among HP seed treatments (medium gray, dark gray, and patterned bars) and bare, untreated seed (light gray) in both early and late season seedling count (as a percent of viable seed sown), in 2018 (panel A) by species, in 2019 (panel D) by species type and herbicide treatment, in 2020 for grasses (panel C) by site and species and in 2020 for sagebrush (ARTR, panel B) by site and herbicide treatment. All data shown used the shallow furrow delivery method, with all broadcast delivery data removed from the two years it was used (2018, 2019). Bars that do not share the same letter are significantly different as determined by post-hoc Tukey HSD test (P < 0.05), with separate tests conducted for each response for each year (and for each site for 2020 grasses). NSD = no significant differences between seed treatments for the comparison shown. Error bars are standard errors. | PMC10062626 | pone.0283678.g004.jpg |
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