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0.395707
db16b60498534ebb8a043b41a60115f1
The proliferation of NHEK cells induced by H1/FGF-7. NHEK cells were seeded onto a 24-well plate at a density of 7500 cells per 500 µL of DK-SFM. The culture was then supplemented with SC powder, F7-SC powder, F7-PH crystals, or rhFGF-7 and incubated at 37 °C and 5% CO2 for 3 days. The amounts of supplemented samples are indicated on the horizontal axis. Cell proliferation rates were determined as viable cell numbers (as measured using the WST-8 assay) relative to non-treated control culture with PBS only. Data are presented as means ± standard deviations (SDs) of triplicate assays. n.s p > 0.05 vs. non-treated control; a p < 0.001 vs. non-treated control; b p < 0.01 vs. 50 µg of F7-SC; c p < 0.001 vs. 100 µg of F7-SC; d p < 0.001 vs. 1 ng of rhFGF-7; and e p < 0.001 vs. of 5 ng of rhFGF-7.
PMC9456417
ijms-23-09953-g004.jpg
0.408433
b1b73b92cd544c0ca9ddc11324bebc90
Migration of NHEK cells induced by H1/FGF-7. NHEK cells at a density of 7500 cells per 500 µL of DK-SFM were incubated at 37 °C and 5% CO2 for 16 h to induce starvation and then wounded via scratching. The wounded cultures were treated with 100 µg of SC powder, 100 µg of F7-SC powder, 5 × 105 F7-PH, or 10 ng of rhFGF-7, or PBS was added (for non-treated control); then, they were further incubated for 24 h. (A) The percentage of wound closure in the scratched NHEK cultures was determined through ImageJ analysis of the photos taken at 0 and at 24 h of treatment. Data are shown as means ± standard deviations (SDs) of triplicate assays. n.s p > 0.05 vs. non-treated control and a p < 0.05 vs. non-treated control. (B) Photos of the scratched cultures for ImageJ analysis. Scale bar, 200 μm.
PMC9456417
ijms-23-09953-g005.jpg
0.431371
5d19a08225ef47618dec370a46b53439
Storage stability of H1/FGF-7 incorporated into sericin-cocoon powder. (A) Short-term (7 days) storage stability. Two identical sets of samples including suspensions of F7-SC powder (2 mg/mL), F7-PH crystals (1 × 107 cubes/mL), and a solution of commercial rhFGF-7 (50 µg/mL) were separately stored at −20 °C or 25 °C for 1 week prior to the assays. NHEK cells at a density of 7500 cells per 500 µL of DK-SFM were supplemented with 100 µg of F7-SC powder, 5 × 105 F7-PH crystals, or 10 ng of rhFGF-7. Proliferative activity of the samples was determined as viable cell number measured in the respective cultures after 3 days of cultivation at 37 °C and 5% CO2. The proliferative activity of the samples stored at −20 °C was set to 100%, and the relative activity of the corresponding samples stored at 25 °C was determined. (B) Long-term (3 months) storage stability of H1/FGF-7. The parameters and analysis method were the same as the 1-week analysis except for sample storage duration. Data are shown as means ± standard deviations (SDs) of triplicate assays. n.s p > 0.05 vs. −20 °C counterpart; a p < 0.001 vs. −20 °C counterpart; and b p < 0.01 vs. −20 °C counterpart.
PMC9456417
ijms-23-09953-g006.jpg
0.46566
993f7b9275424335b6acd8845b16d19f
Three-dimensional (3D) cultivation and differentiation of NHEK cells. NHEK cells were cultivated for 2 days on collagen gel under a submerged condition and continued to grow at the air–liquid interface in a medium containing 1.2 mM Ca2+ with regular medium change until day 14. The 3D-cultivated cell culture was cryo-sectioned for analysis. (A) Hematoxylin and eosin (HE) staining of NHEK cells 3D-cultured (left panel) on collagen gel containing 800 µg of F7-SC powder or (right panel) using basal medium supplemented with 300 ng of rhFGF-7. Scale bar, 20 µm. (B) Immunofluorescent staining for expression of differentiation markers on NHEK cells 3D-cultured on collagen gel containing F7-SC powder. Detection of (left panel) loricrin and keratin 14 and (right panel) filaggrin and keratin 10. Nuclei were stained with 4′,6-diamidino-2-phenylindole (DAPI). Upper layer above the dashed line shows the speculated stratum corneum. Scale bar, 50 μm.
PMC9456417
ijms-23-09953-g007.jpg
0.475702
0737a3ab81d14620b5951fbb14ace9e8
The stiffness degradation of the bolted joint under mixed-mode loading: (a) the mixed-mode loading, (b) the backbone curve.
PMC9457224
materials-15-05817-g001.jpg
0.418004
2f60ec281292498c864c7a4f92675255
(a) The classic Iwan model. (b) Density function of the critical sliding force.
PMC9457224
materials-15-05817-g002.jpg
0.420336
8f489b210f39445f8655ba47fe887cf6
Modification of the classic Iwan model based on experiments: (a) experimental hysteresis loops, (b) the modified model.
PMC9457224
materials-15-05817-g003.jpg
0.505256
d898fca74fc74c1e96390460b44ceabf
Schematic diagram of the microslip friction modeling approach.
PMC9457224
materials-15-05817-g004.jpg
0.469888
806f649495c149f8908097442b42d7d3
(a) The external thread profile. (b) The internal thread profile (The thread pitch P is 1.25 mm, the radius ρn is 0.07 mm, the thread height H is 1.08 mm, and the radius ρ is 0.14 mm).
PMC9457224
materials-15-05817-g005.jpg
0.506067
ed7f29f4ea9b429988a0c66efbd925b4
Finite element models of the bolt and nut: (a) cross section of bolt, (b) cross section of nut, (c) cross section of bolt and nut assembly.
PMC9457224
materials-15-05817-g006.jpg
0.462959
3f0419ba39b541188a84cc4f90a1e981
Simplified bolt model.
PMC9457224
materials-15-05817-g007.jpg
0.471342
7743b8f110c34a22a98619cc9bc91b12
Dimensions of plates (mm).
PMC9457224
materials-15-05817-g008.jpg
0.464708
3f39c0f1ab4e453d93bfde250391e845
Cross section of the finite element model of the plate.
PMC9457224
materials-15-05817-g009.jpg
0.444972
65159b93bbd04224bf80c9297df8ca66
Schematic diagram of bolt preload.
PMC9457224
materials-15-05817-g010.jpg
0.523615
8fada7c3eb9f4c1698fc3c12015acd0e
Initial and boundary conditions.
PMC9457224
materials-15-05817-g011.jpg
0.427138
8379384bb4ee4c6fa7e01fd0a10bceab
Relationship between relative displacement and friction shear stress of different contact methods: (a) Lagrange multiplier method, (b) penalty method (τcrit is the critical friction shear stress, γcrit is the relative displacement of critical sliding.).
PMC9457224
materials-15-05817-g012.jpg
0.471678
3e50e687219742509572b099490c7704
The lapped plate under mixed-mode loading.
PMC9457224
materials-15-05817-g013.jpg
0.535755
79c3a9e8e1fa4e709290d7ca896c749b
The mesh convergence curve.
PMC9457224
materials-15-05817-g014.jpg
0.488545
194f7bbd9da5418fa511037e84b5903c
The finite element model of lapped plates.
PMC9457224
materials-15-05817-g015.jpg
0.487326
abe7c7a21b3b4dbf97fcaf535d2df85f
Calculation results of the Lagrange multiplier method and the penalty method: (a) contact pressure distribution curves, (b) backbone curves.
PMC9457224
materials-15-05817-g016.jpg
0.44998
a55b9a3b71b247bf87c7101a1e809de5
Pressure distribution on the inter-plate surface: (a) scanning paths on the inter-plate surface, (b) the pressure distribution of the two models.
PMC9457224
materials-15-05817-g017.jpg
0.476856
dc1b0eeff04149f7969877fdbb458604
Dynamic degradation of the thread model and simplified model under mixed-mode loading: (a) backbone curves, (b) stiffness degradation curves, (c) calculation time.
PMC9457224
materials-15-05817-g018.jpg
0.501826
0c14d2dfefbd4021881571d01a866b50
Force decomposition.
PMC9457224
materials-15-05817-g019.jpg
0.455693
45d7c471e29e43b0b3535443d4a9ede0
The evolution of contact conditions under mixed-mode loading: (a) Contact condition on the bolthead-plate surface, (b) contact condition on the inter-plate surface: (b1) T = 0 N, (b2) T = 228.555 N, (b3) T = 489.332 N, (b4) T = 575.232 N, (b5) T = 632.458 N.
PMC9457224
materials-15-05817-g020.jpg
0.388401
b2ecb1293bc24ea9a32c2027b4e6369d
Pressure distribution on the inter-plate surface under mixed-mode loading: (a) T = 0 N, (b) T = 228.555 N, (c) T = 489.332 N, (d) T = 575.232 N, (e) T = 632.458 N.
PMC9457224
materials-15-05817-g021.jpg
0.420996
ae01afedaf4b4e5cbe7cf3e248034c3d
Ellipse modification in microslip.
PMC9457224
materials-15-05817-g022.jpg
0.429292
c57400dccac74eca9f88cc5d0fa17790
Ellipticity discrete method: (a) isolines of pressure on the inter-plate surface, (b) ellipticity discrete method.
PMC9457224
materials-15-05817-g023.jpg
0.485186
663d59e9c4c04a528e3f3b6c76eca9e0
The displacement of the bolt in the x-direction.
PMC9457224
materials-15-05817-g024.jpg
0.671158
f29c75e62e3945259260037d13ad2225
SARS-CoV-2 Mpro inhibitors: (a): Perampanel; and (b): Perampanel derivatives after structure optimization.
PMC9457583
molecules-27-05732-g001.jpg
0.576585
b507407efc0743fa9cf623a18aeed105
SARS-CoV-2 Mpro inhibitor Bispidine derivative.
PMC9457583
molecules-27-05732-g002.jpg
0.650601
f0467084a80444249995fd6beeb2bfad
SARS-CoV-2 Mpro inhibitors: (a): Valrycin B; (b): Z-FA-FMK; and (c): MG–132.
PMC9457583
molecules-27-05732-g003.jpg
0.662644
c8f495373a3a4f7e8651ce851cb39f62
SARS-CoV-2 Mpro inhibitor PF-07321332 (nirmatrelvir), which was granted authorization by FDA in December 2021.
PMC9457583
molecules-27-05732-g004.jpg
0.577814
2d71d4653d9744509f09b8ce861d0993
Remdesivir is an inhibitor of the SARS-CoV-2 Mpro.
PMC9457583
molecules-27-05732-g005.jpg
0.632897
258aea1f92034138bfc007fed8ff7061
Non-specific promiscuous SARS-CoV-2 Mpro inhibitors: (a): Ebselen; (b): Disulfiram; (c): Tideglusib; (d): Carmofur; (e): Shikonin; and (f): PX-12.
PMC9457583
molecules-27-05732-g006.jpg
0.63756
ee143c53bd2d4dfbaacefd517c5dc0bc
SARS-CoV-2 Mpro inhibitor S-217622, which is under clinical development.
PMC9457583
molecules-27-05732-g007.jpg
0.415141
de74e421cc0c41aa9fa7ae8939a96936
Active compounds with experimentally confirmed activity against SARS-CoV-2 found at the first step of the study.
PMC9457583
molecules-27-05732-g008.jpg
0.395976
f1da028b99294604a482391182fcd6b7
Structures of the ligands presented in Table 2. They are analogs of three compounds presented in Table 1.
PMC9457583
molecules-27-05732-g009.jpg
0.455048
25419cd6e92b44188258bf3a6174b647
Docking position of compound 3a in the active site of Mpro. The ligand is shown in a “ball-and-stick” model and colored in brown. Protein residues are presented in the “line” model and colored in marine. Residues of a catalytic dyad are colored in magenta. A yellow dashed line indicates an H-bond between the protein and the ligand. Pi-stacking is designated with a green dashed line.
PMC9457583
molecules-27-05732-g010.jpg
0.52309
affa1f0defc24539944400aab1bad65c
Synthesis of the target compounds (3 a-d). Reagents and conditions: (i) dry toluene; dry pyridine, reflux, 5 h.
PMC9457583
molecules-27-05732-sch001.jpg
0.547612
ac3ebb6291154181bce0e0a9f416dc63
Synthesis of the target compounds (6 a-c). Reagents and conditions: (ii) dry DMF, CH3COOK, piperidine-1-yldithiocarboxylic acid (b) or 2-methylpiperidine-1-yldithiocarboxylic acid (c), 80 °C, 6 h; (iii) dry CH3CN, morpholine, reflux, 3 h; and (iv) dry DMF, CsF, 2-chlorobenzyl chloride, reflux, 4 h.
PMC9457583
molecules-27-05732-sch002.jpg
0.585909
c0715829354e41d2a997dafa7e5187e0
Synthesis of the target compounds (9 a-c). Reagents and conditions: (v) CH3CN, K2CO3, 80 °C, 3 h.
PMC9457583
molecules-27-05732-sch003.jpg
0.490442
23b4d1b2866141578027ecb5055ef32d
SEM images of waste and recycled carbon fiber (CF) acquired through different recycling methods. (a) CFRP scrap wastes, (b) recycled CFs from supercritical method, (c) recycled CFs from superheated steam pyrolysis, and (d) virgin CFs.
PMC9457743
molecules-27-05663-g001.jpg
0.417966
303224ceedd148dc98554fb72b4d3f29
Charpy test results of the impact strength of RCF-reinforced low-density polyethylene (LDPE).
PMC9457743
molecules-27-05663-g002.jpg
0.444032
03fd6c0317c743fc8061d28ae3be0288
SEM images of the fractured surfaces of polymer composites with CF types acquired from the Charpy pendulum impact test. (a) PE/SW, (b) PE/SC-RCF, (c) PE/SHS-RCF, and (d) PE/CF.
PMC9457743
molecules-27-05663-g003.jpg
0.435387
8b661613ad384deeafb7b1b7a6e0e024
A schematic of interfacial adhesion changes of carbon fibers by recycling methods.
PMC9457743
molecules-27-05663-g004.jpg
0.398698
5478edc9591247f5bf2dc699cb06113a
Three Axes of Spinal Cord Development: Rostrocaudal, Dorsoventral, and Mediolateral (A) Positional identity in the posterior CNS is defined by overlapping expression of HOX transcription factors: hindbrain (HOX1-4), cervical (HOX4-8), thoracic (HOX8-9), lumbar (HOX9-11) and sacral (HOX12-13). (B). Dorsoventral patterning occurs in response to roof plate (RP) and ectoderm-derived TGFβ, BMP, and Wnt signaling and floor plate (FP) and notochord-derived Sonic Hedgehog (Shh) and Noggin signaling. Schematic shows 11 discrete progenitor domains (plus a lateborn dorsal progenitor domain) and corresponding post-mitotic cardinal neuron populations with characteristic transcription factor marker expression. (C) Once outside the ependymal layer, progenitors differentiate into post-mitotic neurons and migrate to their final settling positions in the mantle layer. The mechanisms that regulate birthdate are poorly understood but have significant influence on neuronal migration and projection patterns.
PMC9458954
fcell-10-942742-g001.jpg
0.388083
c77648e68dfb4413b35a9df83b74b401
Bioengineering Strategies for Spinal Cord Organoids (A) Spatial confinement using biomaterials, including micropatterned substrates, enables control over tissue size and structure. Culture conditions can be used to refine whether organoids are wholly neural (including brain vs. spinal) or multi-lineage gastruloids representing multiple germ layers. (B). Microfluidics in 2D or 3D can be used to generate orthogonal gradients capable of patterning the wide spectrum of cell types formed along the rostrocaudal and dorsoventral axes during spinal development (C) Addition of genetically engineered cells to organoids can enable vasculature, morphogen patterning, or optogenetic stimulation for improved cell type patterning and maturation.
PMC9458954
fcell-10-942742-g002.jpg
0.422266
57dc33cd23534f61994f7343b64e3c0d
General diagram of the proposed method.
PMC9460171
sensors-22-06503-g001.jpg
0.451828
0beaa8e6068743d3a932325777314201
The architecture of the deep learning model.
PMC9460171
sensors-22-06503-g002.jpg
0.439131
4c646f2d0b0f48028bcf61d850ff5a00
Convergence of the proposed (customized) activation function and the sigmoid function.
PMC9460171
sensors-22-06503-g003.jpg
0.42456
c7805761d5554300a416fb68c85eb3f7
Confusion matrix of the proposed end-to-end CNN model.
PMC9460171
sensors-22-06503-g004.jpg
0.456979
30445ff4cd084b10a0c2a80adf96ee41
Proposed end-to-end CNN training and validation accuracy curve.
PMC9460171
sensors-22-06503-g005.jpg
0.510153
171ec98f07fb4fef8004c32229947663
Proposed end-to-end CNN training and validation error curve.
PMC9460171
sensors-22-06503-g006.jpg
0.445702
01315aa07acb4034b64208431baf1d24
Confusion matrix of the SVM classifier.
PMC9460171
sensors-22-06503-g007.jpg
0.421003
7e6e225ab22449a491e4b99ceb4b7694
Schematic of the main performers in the tissue-paper-embossing process.
PMC9460798
polymers-14-03448-g001.jpg
0.382224
f5d65a472707464b9dcaeabcc4fabc64
Images of the 3D steel embossing plates with the deco pattern and micropattern, and details of the respective finishing geometries: (a) deco pattern with straight lines, (b) deco pattern with round lines, (c) micropattern with straight dots, and (d) micropattern with round dots.
PMC9460798
polymers-14-03448-g002.jpg
0.419285
43b71f48d2a74634a9ba634f1ea02a12
Finishing geometry and dimensions of the lines and dots engraved in the 3D steel plates: (a) line with a round finishing, (b) dot with a round finishing, (c) line with a straight finishing, and (d) dot with a straight finishing.
PMC9460798
polymers-14-03448-g003.jpg
0.46916
7c3eaa22b6414024a739adf319ffc247
Model dimensions, characteristics, and boundary conditions.
PMC9460798
polymers-14-03448-g004.jpg
0.372495
760c85f6eff046608152cf25a28221bc
Results of mechanical characterization and bulk obtained for all the embossed samples and the reference paper, B, for the different finishing geometries of the 3D steel plates.
PMC9460798
polymers-14-03448-g005.jpg
0.398903
59a4dd44c4ee4cc69a97eed2d79ec398
Global views of the tissue-paper samples engraved with the different considered embossing plates: (a) Bdsl (front side), (b) Bdrl (front side), (c) Bdsl (back side), (d) Bdrl (back side), (e) Bmsd (front side), (f) Bmrd (front side), (g) Bmsd (back side), and (h) Bmrd (back side).
PMC9460798
polymers-14-03448-g006.jpg
0.385185
7be68943d1d04f46a6d88514f9431f81
Different views of the 3D maps created for the front and back sides of the tissue-paper sample Bdsl.
PMC9460798
polymers-14-03448-g007.jpg
0.427317
bdb19cb585ca41dfb37e2cd088569b97
Different views of the 3D maps created for the front and back sides of the tissue-paper sample Bdrl.
PMC9460798
polymers-14-03448-g008.jpg
0.437538
12728b3b986f47dda814b36e7234d978
Different views of the 3D maps created for the front and back sides of the tissue-paper sample Bmsd.
PMC9460798
polymers-14-03448-g009.jpg
0.431341
bfb5606ddd2144f197932404215e51bb
Different views of the 3D maps created for the front and back sides of the tissue-paper sample Bmrd.
PMC9460798
polymers-14-03448-g010.jpg
0.434746
5da38e29c654428daafcc42e6eae0de1
Spreading dynamics of a liquid droplet from t = 35.7 ms to 3 s for the tissue-paper sample Bdsl.
PMC9460798
polymers-14-03448-g011.jpg
0.462168
554c51912812463cbc7c068c5cd65236
Spreading dynamics of a liquid droplet from t = 35.7 ms to 3 s for the tissue-paper sample Bdrl.
PMC9460798
polymers-14-03448-g012.jpg
0.416807
c2a458a8007640b689a880825d32268a
Spreading dynamics of a liquid droplet from t = 35.7 ms to 3 s for the tissue-paper sample Bmsd.
PMC9460798
polymers-14-03448-g013.jpg
0.400041
19e0557d8257419ca133df7b952b31c7
Spreading dynamics of a liquid droplet from t = 35.7 ms to 3 s for the tissue-paper sample Bmrd.
PMC9460798
polymers-14-03448-g014.jpg
0.461968
03e7d9c04a79425f9d5afd5cf686d792
Comparative graphs of the spreading dynamics of a liquid droplet for the tissue-paper samples Bdsl (in blue), Bdrl (in red), Bmsd (in green), and Bmrd (in yellow).
PMC9460798
polymers-14-03448-g015.jpg
0.397651
6a8c8cc580224ba38303fa3130903e61
Results obtained for handfeel (HF) for all the embossed samples and the reference paper, B, for the different finishing geometries of the 3D steel plates.
PMC9460798
polymers-14-03448-g016.jpg
0.481525
54fc34898634446f9c3fb3aba3d14c71
Handfeel (HF) behavior as a function of bulk.
PMC9460798
polymers-14-03448-g017.jpg
0.438041
7631ec937cc6485f843c8847221819f2
Plastic-stress-field finite-element results for deco pattern with round finishing.
PMC9460798
polymers-14-03448-g018.jpg
0.444101
a0716f36095e444a85c29ed3e8120d71
Plastic-stress-field finite-element results for deco pattern with straight finishing.
PMC9460798
polymers-14-03448-g019.jpg
0.447608
8369ba22346a4b99bc7e7d5733794031
Plastic-stress-field finite-element results for micropattern with round finishing.
PMC9460798
polymers-14-03448-g020.jpg
0.510443
b79eb8f4d1264e1a8d1b269916e1dc9c
Plastic-stress-field finite-element results for micropattern with straight finishing.
PMC9460798
polymers-14-03448-g021.jpg
0.483516
a8b9676830c447548ed6e5b2faeaec4a
Heat pipe operation [56].
PMC9460871
sensors-22-06367-g001.jpg
0.406031
a0b5a97ab31949faa6d3d583e8306f7f
Modified PV panel with integrated fanless heat pipe sink.
PMC9460871
sensors-22-06367-g002.jpg
0.396236
8aa942a910ec4021b8dfdc1a183df988
Fanless heat pipe sink.
PMC9460871
sensors-22-06367-g003.jpg
0.448094
8b669db54383491fa5688f77d84abe3d
(a) Experimental setup (b) Schematic diagram of experimental test rig.
PMC9460871
sensors-22-06367-g004.jpg
0.473506
7a8a1b1f888643fda934bd8aab9abfe7
Effect of temperature on efficiency and global solar radiation (obtained from PVsyst software).
PMC9460871
sensors-22-06367-g005.jpg
0.438362
67170032a0164a1ea20286b4f1748793
Effect of incident radiation on the P-V plot at 45 °C cell temperature (obtained from PVsyst software).
PMC9460871
sensors-22-06367-g006.jpg
0.407084
c9b4de01147d424e8c4fa1fd59fd4de4
Weather characteristics for the period of the experiment (i.e., solar radiation and ambient temperature).
PMC9460871
sensors-22-06367-g007.jpg
0.481128
13d9d8d9edb24992a35bce4e3b3f4f07
Weather characteristics for the period of the experiment day in relative humidity and wind speed.
PMC9460871
sensors-22-06367-g008.jpg
0.518765
e4530835138144d19fa65d5a6715b10c
Time dependence of temperature of the two PV panels.
PMC9460871
sensors-22-06367-g009.jpg
0.358517
bce3a4f53a0a4dd1a70806b747dc3ca3
Thermal image of a cooled PV panel.
PMC9460871
sensors-22-06367-g010.jpg
0.411439
5e8f65b638a94459b1e555e8f4e17939
Thermal image of an uncooled PV panel.
PMC9460871
sensors-22-06367-g011.jpg
0.506698
59d086fbc25049cdaf6a3d135d87f7ca
Time dependence of (a) Voltage and (b) Current of both PV panels.
PMC9460871
sensors-22-06367-g012.jpg
0.499864
2d112cf3f12c44dab5163cda72abf96a
Temperature dependence power output of both PV panels.
PMC9460871
sensors-22-06367-g013.jpg
0.429476
334de8af4d1f4294bc3e20a7d87b6d2b
Time dependence (a) electrical efficiency (b) improvement in efficiency.
PMC9460871
sensors-22-06367-g014.jpg
0.447715
adb4f4d8f8fd40b2b33357171a897fed
Time-dependent exergy efficiency.
PMC9460871
sensors-22-06367-g015.jpg
0.477235
395fbb0a811c4e59bcf14b2cfec9d8f9
Recruitment profile for stroke cases and controls at Nsambya hospital in Kampala, Uganda (2016–2018).
PMC9461590
gr1.jpg
0.419266
6706a7d617804b39be9580c593c3205c
Dot plot showing age for ischaemic and haemorrhagic stroke patients in Kampala, Uganda (2016–2018).
PMC9461590
gr2.jpg
0.463522
d17bc36af7884a04a34fa04fc852d128
Mediation model. Parenting behaviour as a mediator of the relationship between financial worry and child SDQ. ACME, average causal mediation effect; ADE, average direct effect; SDQ, Strengths and Difficulties Questionnaire.
PMC9462077
bmjpo-2022-001569f01.jpg
0.408459
8a20284feffa4854861c5aeda24a05d7
(A) Hematoxylin and eosin (H&E) staining images of the pyramidal cells in the hippocampus CA1 region of the control, AD model, donepezil, and pine nut groups. The black arrowhead represents normal cells and the red arrowhead represents distorted cells. (B) Acetylcholine (Ach) level, (C) acetylcholinesterase (AchE) activity, and (D) choline acetyltransferase (ChAT) activity of control, AD model, donepezil, and pine nut groups (mean ± standard deviation, ∗P < 0.05 presented comparing with model group, #P < 0.05 and ##P < 0.01 presented comparing with drug (donepezil or pine nut) group).
PMC9463486
gr1.jpg
0.420235
2c40dad6bc324ed3831e31146bbff695
(A–D) Regression curves between N/N0 and the factor's threshold in the plasma sample. N is the number of variables that meets the factor's threshold. N0 is the number of initial variables. a, b, c, and d represent the thresholds of variable importance in projection (VIP), fold change (FC), area under receiver operator characteristic curve (AUROC), and −ln(P value), respectively. (E–H) The R2X, R2Y, and Q2 values of the partial least squares-discriminant analysis (PLS-DA) models performed by the variable sets selected through considering the thresholds of (E) VIP, (F) FC, (G) AUROC , and (H) –ln(P value) in the plasma sample.
PMC9463486
gr2.jpg
0.405509
9bc7676cf93d407b98c26a816eb77349
(A–C) Wayne plots of the numbers of variables meeting the requirements of multi-factor in plasma, hippocampus, and cortex samples. The best multi-factor combination is marked in blue in the Wayne plot. (D–F) The score plots and parameters of PLS-DA model performed by the best combination in plasma, hippocampus, and cortex samples. Black and red circles represent the control and AD model groups, respectively. (G–I) The receiver operator characteristic curves of the variables of the best combinations in the plasma, hippocampus, and cortex samples. (J–L) The score plots of PLS-DA models performed by the selected variables of control, AD model, and donepezil groups in the plasma, hippocampus, and cortex samples. Therapeutic effect of donepezil was reflected by the curative direction towards the control group. Black, red, and green circles represent the control, AD model and donepezil groups, respectively. The red arrowhead represents the modeling direction, and the green arrowhead represents the curative direction. (M–O) The score plots of PLS-DA models performed by the selected variables of control, AD model, and pine nut groups. The therapeutic effect of pine nut was reflected by the curative direction towards the control group. Black, red, and light blue circles represented control, AD model, and pine nut groups, respectively. The red arrowhead represents the modeling direction, and the light blue arrowhead represents the curative direction.
PMC9463486
gr3.jpg
0.503752
3cd350b46d4442d4b27b67d2c3d66c08
(A, D, and G) The score plots and parameters of the PLS-DA models performed by the variables selected by usual procedure in plasma, hippocampus, and cortex samples. Black and red circles represent the control and AD model groups, respectively. (B, E, and H) The score plots of the PLS-DA models performed by the selected variables of the control, AD model, and donepezil groups in plasma, hippocampus, and cortex samples. Black, red, and green circles represent the control, AD model, and donepezil groups, respectively. The red arrowhead represents the modeling direction. (C, F, and I) The score plots of PLS-DA models performed by the selected variables of control, AD model, and pine nut groups in plasma, hippocampus, and cortex samples. Black, red, and light blue circles represent the control, AD model, and pine nut group, respectively. The red arrowhead represents the modeling direction.
PMC9463486
gr4.jpg
0.461222
d723ec5da9dd4e34825a02a68ecc6f47
Flow chart of the study.
PMC9465333
fphar-13-944158-g001.jpg
0.435713
da5e223a2d544c4ab89db966ec06bb69
Identification of necroptosis-related lncRNAs in OS. (A). The heatmap of 218 differentially expressed necroptosis-related lncRNAs. T represents tumor tissue, and N represents normal tissue. (B). The volcano of 218 differentially expressed necroptosis-related lncRNAs. (C). The correlation network between necroptosis-related lncRNAs. (D). The prognostic lncRNAs extracted by univariate Cox regression analysis.
PMC9465333
fphar-13-944158-g002.jpg
0.426485
13edd22d635b408eb7356f91df53e29b
Construction of a prognostic pyroptosis-associated lncRNA signature. (A,B). The LASSO Cox analysis determined 15 prognostic genes. (C). The forest map of multivariate Cox analysis. (D). The network between lncRNAs and necroptosis genes (correlation coefficients > 0.3 and p < 0.001).
PMC9465333
fphar-13-944158-g003.jpg