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http://www.ncbi.nlm.nih.gov/pubmed/29095980,http://www.ncbi.nlm.nih.gov/pubmed/17488757 | Which web-based pedigree editors are available? | Pedigreejs and Madeline 2.0 Pedigree Drawing Engine (PDE) |
http://www.ncbi.nlm.nih.gov/pubmed/30365900,http://www.ncbi.nlm.nih.gov/pubmed/30269642,http://www.ncbi.nlm.nih.gov/pubmed/30521757,http://www.ncbi.nlm.nih.gov/pubmed/29891587 | What is the mechanism of action of Solriamfetol? | Solriamfetol is a selective norepinephrine-dopamine reuptake inhibitor. It is used to treat excessive sleepiness in obstructive sleep apnea and narcolepsy patients. |
http://www.ncbi.nlm.nih.gov/pubmed/29575326 | What is the difference between the nuclease Cas13a and C2c2 | Cas13a was previously called C2c2. |
http://www.ncbi.nlm.nih.gov/pubmed/30072652,http://www.ncbi.nlm.nih.gov/pubmed/28946360,http://www.ncbi.nlm.nih.gov/pubmed/29342865,http://www.ncbi.nlm.nih.gov/pubmed/22612266,http://www.ncbi.nlm.nih.gov/pubmed/29344826,http://www.ncbi.nlm.nih.gov/pubmed/29608860 | Phlorotannin is extracted from what plant? | Phlorotannin is extracted from Brown Seaweed or brown Algaephlorotannins present in brown seaweeds Phlorotannins, phenolic compounds produced exclusively by seaweeds |
http://www.ncbi.nlm.nih.gov/pubmed/29932112,http://www.ncbi.nlm.nih.gov/pubmed/28735901,http://www.ncbi.nlm.nih.gov/pubmed/25505382,http://www.ncbi.nlm.nih.gov/pubmed/26386583,http://www.ncbi.nlm.nih.gov/pubmed/24300303 | Where are pannexins localized? | Pannexins (Panxs) are a multifaceted family of ion and metabolite channels that play key roles in a number of physiological and pathophysiological settings. These single membrane large-pore channels exhibit a variety of tissue, cell type, and subcellular distributions. |
http://www.ncbi.nlm.nih.gov/pubmed/29729086,http://www.ncbi.nlm.nih.gov/pubmed/28531264,http://www.ncbi.nlm.nih.gov/pubmed/26723167,http://www.ncbi.nlm.nih.gov/pubmed/30131592,http://www.ncbi.nlm.nih.gov/pubmed/30322874,http://www.ncbi.nlm.nih.gov/pubmed/26586950,http://www.ncbi.nlm.nih.gov/pubmed/28478771,http://www.ncbi.nlm.nih.gov/pubmed/25083572,http://www.ncbi.nlm.nih.gov/pubmed/29722587,http://www.ncbi.nlm.nih.gov/pubmed/27440212,http://www.ncbi.nlm.nih.gov/pubmed/23320989,http://www.ncbi.nlm.nih.gov/pubmed/29559781,http://www.ncbi.nlm.nih.gov/pubmed/23138433 | What is the mechanism of action of cariprazine? | Cariprazine is a dopamine D3/D2 partial agonist atypical antipsychotic with preferential binding to D3 receptors. Cariprazine shows also has affinity for 5-HT2B, and 5-HT1A receptors. It also shows moderate affinity toward σ1, 5-HT2A, and histamine H1 receptors. It is approved for the treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder |
http://www.ncbi.nlm.nih.gov/pubmed/29659705 | Which tool is used to visualise the junction sites of chloroplast genomes? | IRscope is an online program to visualize the junction sites of chloroplast genomes. It allows the users to depict the genetic architecture of up to ten chloroplast genomes in the vicinity of the sites connecting the inverted repeats to the short and long single copy regions. The software and its dependent libraries are fully coded in R and the reflected plot is scaled up to realistic size of nucleotide base pairs in the vicinity of the junction sites. The input of the program is an annotation GenBank (.gb) file, the accession or GI number of the sequence or a DOGMA output file. |
http://www.ncbi.nlm.nih.gov/pubmed/21036864,http://www.ncbi.nlm.nih.gov/pubmed/19674480,http://www.ncbi.nlm.nih.gov/pubmed/29069336 | Which curated databases exist for spider-venom toxins? | ArachnoServer and its updated version ArachnoServer 2.0 are manually curated databases providing information on the sequence, structure and biological activity of protein toxins from spider venoms. |
http://www.ncbi.nlm.nih.gov/pubmed/29189942 | What is the difference between CRISPR-Cas12a and CRISPR-Cpf1? | CRISPR-Cas12a and CRISPR-Cpf1 refer to the same thing. |
http://www.ncbi.nlm.nih.gov/pubmed/28232034,http://www.ncbi.nlm.nih.gov/pubmed/27905086,http://www.ncbi.nlm.nih.gov/pubmed/29760164,http://www.ncbi.nlm.nih.gov/pubmed/28636484,http://www.ncbi.nlm.nih.gov/pubmed/28480750,http://www.ncbi.nlm.nih.gov/pubmed/28865041,http://www.ncbi.nlm.nih.gov/pubmed/27757389,http://www.ncbi.nlm.nih.gov/pubmed/25486992,http://www.ncbi.nlm.nih.gov/pubmed/28730660,http://www.ncbi.nlm.nih.gov/pubmed/29234211 | Please list 2 antitoxin antibodies approved by the FDA for reducing the recurrence of Clostridium difficile infection | The antitoxin antibodies actoxumab and bezlotoxumab bind to and neutralize TcdA and TcdB, respectively. Bezlotoxumab was recently approved by the FDA for reducing the recurrence of CDI. |
http://www.ncbi.nlm.nih.gov/pubmed/29756573,http://www.ncbi.nlm.nih.gov/pubmed/26137081,http://www.ncbi.nlm.nih.gov/pubmed/25535701 | List the functions of the protein lactotransferrin. | Lactotransferrin has numerous biological roles, including the regulation of iron absorption and modulation of immune responses, and has anti-microbial, anti-viral, antioxidant, anti-cancer, and anti-inflammatory activities. |
http://www.ncbi.nlm.nih.gov/pubmed/21306953,http://www.ncbi.nlm.nih.gov/pubmed/24328549,http://www.ncbi.nlm.nih.gov/pubmed/25647781 | Does Axitinib prolong survival of Pancreatic Cancer patients? | No. The addition of axitinib to gemcitabine does not improve overall survival in advanced pancreatic cancer. |
http://www.ncbi.nlm.nih.gov/pubmed/29608663 | Which Python tool has been developed for network-based stratification of tumor mutations? | PyNBS is a modularized Python 2.7 implementation of the network-based stratification (NBS) algorithm for stratifying tumor somatic mutation profiles into molecularly and clinically relevant subtypes. |
http://www.ncbi.nlm.nih.gov/pubmed/19752190 | Through which protein interaction does MLP regulate F-actin dynamics? | The interaction of MLP with CFL2 has direct implications in actin cytoskeleton dynamics in regulating CFL2-dependent F-actin depolymerization, with maximal depolymerization enhancement at an MLP/CFL2 molecular ratio of 2:1. Deregulation of this interaction by intracellular pH variations, CFL2 phosphorylation, MLP or CFL2 gene mutations, or expression changes, as observed in a range of cardiac and skeletal myopathies, could impair F-actin depolymerization, leading to sarcomere dysfunction and disease. |
http://www.ncbi.nlm.nih.gov/pubmed/27956832,http://www.ncbi.nlm.nih.gov/pubmed/24201088,http://www.ncbi.nlm.nih.gov/pubmed/28872268,http://www.ncbi.nlm.nih.gov/pubmed/25200592,http://www.ncbi.nlm.nih.gov/pubmed/29854129,http://www.ncbi.nlm.nih.gov/pubmed/25084822,http://www.ncbi.nlm.nih.gov/pubmed/17885828,http://www.ncbi.nlm.nih.gov/pubmed/29706156,http://www.ncbi.nlm.nih.gov/pubmed/23666287 | Is there any association between suicide and autism in adolescents, yes or no? | Adults with autism spectrum disorder (ASD) are at increased risk of suicide compared to the general population. |
http://www.ncbi.nlm.nih.gov/pubmed/23069661,http://www.ncbi.nlm.nih.gov/pubmed/25370482,http://www.ncbi.nlm.nih.gov/pubmed/18697201,http://www.ncbi.nlm.nih.gov/pubmed/23479198,http://www.ncbi.nlm.nih.gov/pubmed/26137081 | Is lactotransferrin a tumour suppressor? | Lactotransferrin (LTF) has been confirmed to act as a tumor suppressor in multiple cancers. |
http://www.ncbi.nlm.nih.gov/pubmed/27733560,http://www.ncbi.nlm.nih.gov/pubmed/27090868,http://www.ncbi.nlm.nih.gov/pubmed/28494719,http://www.ncbi.nlm.nih.gov/pubmed/29161531,http://www.ncbi.nlm.nih.gov/pubmed/27743318,http://www.ncbi.nlm.nih.gov/pubmed/27345931,http://www.ncbi.nlm.nih.gov/pubmed/30479171 | What is CVT-301? | CVT-301 is inhaled levodopa (LD) formulation for development as a self-administered treatment for relief of OFF periods in Parkinson's disease. CVT-301 provided rapid improvement of motor function, and daily OFF time was significantly reduced at the higher dose. |
http://www.ncbi.nlm.nih.gov/pubmed/29547981 | Are there tools for visualizing and processing long-read sequencing data? | Yes. Tools such as NanoPack for instance have been developed for visualization and processing of long-read sequencing data from Oxford Nanopore Technologies and Pacific Biosciences. |
http://www.ncbi.nlm.nih.gov/pubmed/28389707 | Name siRNA drugs that have entered phase 2-3 clinical trials (by 2019). | siRNAs that have entered phase 2-3 clinical trials by 2019 include PF-04523655, TKM-080301, Atu027, SYL040012, SYL1001, siG12D-LODER (phase 2), QPI-1002, QPI-1007, and patisiran (phase 3). |
http://www.ncbi.nlm.nih.gov/pubmed/29032508,http://www.ncbi.nlm.nih.gov/pubmed/17960769,http://www.ncbi.nlm.nih.gov/pubmed/20670215,http://www.ncbi.nlm.nih.gov/pubmed/18634911,http://www.ncbi.nlm.nih.gov/pubmed/26547205,http://www.ncbi.nlm.nih.gov/pubmed/18440731 | Where is fatty acid binding protein 2 expressed? | fatty acid binding protein 2 is expressed by intestinal epithelial cells |
http://www.ncbi.nlm.nih.gov/pubmed/30409855,http://www.ncbi.nlm.nih.gov/pubmed/26664771,http://www.ncbi.nlm.nih.gov/pubmed/26612766,http://www.ncbi.nlm.nih.gov/pubmed/29574468,http://www.ncbi.nlm.nih.gov/pubmed/24464444 | Which gene mutation is associated with Woodhouse Sakati syndrome? | DCAF17 mutations are associated with Woodhouse-Sakati syndrome, a rare disorder characterized by alopecia, hypogonadotropic hypogonadism, sensorineural hearing loss, diabetes mellitus, and extrapyramidal movements. |
http://www.ncbi.nlm.nih.gov/pubmed/27446120,http://www.ncbi.nlm.nih.gov/pubmed/30052912,http://www.ncbi.nlm.nih.gov/pubmed/29733382,http://www.ncbi.nlm.nih.gov/pubmed/25506822 | Mention computational tools that have been developed for alternative polyadenylation (APA) sites analysis | TAPAS, PlantAPA and IntMAP |
http://www.ncbi.nlm.nih.gov/pubmed/30251172 | What is patisiran? | Patisiran (ONPATTRO™) is a double-stranded small interfering RNA encapsulated in a lipid nanoparticle for delivery to hepatocytes. By specifically binding to a genetically conserved sequence in the 3' untranslated region of mutant and wild-type transthyretin (TTR) messenger RNA, patisiran causes its degradation (via RNA interference) and subsequently a reduction in serum TTR protein levels and tissue TTR protein deposits. It has been approved in the USA for the treatment of the polyneuropathy of hereditary TTR-mediated amyloidosis (hATTR) in adults and subsequently approved in the EU for the treatment of hATTR in adults with stage 1 or 2 polyneuropathy. |
http://www.ncbi.nlm.nih.gov/pubmed/23683707,http://www.ncbi.nlm.nih.gov/pubmed/21429248,http://www.ncbi.nlm.nih.gov/pubmed/9421300,http://www.ncbi.nlm.nih.gov/pubmed/29355908,http://www.ncbi.nlm.nih.gov/pubmed/15638775,http://www.ncbi.nlm.nih.gov/pubmed/20650103,http://www.ncbi.nlm.nih.gov/pubmed/14704462,http://www.ncbi.nlm.nih.gov/pubmed/26661741,http://www.ncbi.nlm.nih.gov/pubmed/12972172,http://www.ncbi.nlm.nih.gov/pubmed/15112861,http://www.ncbi.nlm.nih.gov/pubmed/21549021,http://www.ncbi.nlm.nih.gov/pubmed/22696384 | Losigamone can be used for treatment of which disease? | Losigamone is sometimes used as an add-on therapy for epilepsy. |
http://www.ncbi.nlm.nih.gov/pubmed/24174536,http://www.ncbi.nlm.nih.gov/pubmed/24253304,http://www.ncbi.nlm.nih.gov/pubmed/27789702,http://www.ncbi.nlm.nih.gov/pubmed/29069466 | Which curated data resources for ChIP-seq data are available? | The MGA repository, Cistrome Data Browser, CR Cistrome and GeneProf data. |
http://www.ncbi.nlm.nih.gov/pubmed/29254998 | How many pseudokinases are there in the human kinome? | There are approximately 50 pseudokinases in the human kinome. |
http://www.ncbi.nlm.nih.gov/pubmed/28736830,http://www.ncbi.nlm.nih.gov/pubmed/29424317,http://www.ncbi.nlm.nih.gov/pubmed/29451410,http://www.ncbi.nlm.nih.gov/pubmed/29516321,http://www.ncbi.nlm.nih.gov/pubmed/28306389,http://www.ncbi.nlm.nih.gov/pubmed/30487231,http://www.ncbi.nlm.nih.gov/pubmed/27959715,http://www.ncbi.nlm.nih.gov/pubmed/29735484,http://www.ncbi.nlm.nih.gov/pubmed/29850255,http://www.ncbi.nlm.nih.gov/pubmed/30011788,http://www.ncbi.nlm.nih.gov/pubmed/30375244 | What is the mechanism of action of Inclisiran? | Inclisiran, a novel, synthetic, siRNA molecule, inhibits PCSK9 synthesis in hepatocytes. Inclisiran targets intracellular PCSK9 synthesis specifically, resulting in a dose-dependent, long-term, significant reduction in LDL-C. |
http://www.ncbi.nlm.nih.gov/pubmed/29335563 | Which tool has been developed for visualization of non-covalent contacts? | Visualizations of biomolecular structures empower us to gain insights into biological functions, generate testable hypotheses, and communicate biological concepts. Typical visualizations (such as ball and stick) primarily depict covalent bonds. In contrast, non-covalent contacts between atoms, which govern normal physiology, pathogenesis, and drug action, are seldom visualized. The Protein Contacts Atlas has been developed as an interactive resource of non-covalent contacts from over 100,000 PDB crystal structures. This resource enables researchers from different disciplines to investigate diverse questions in the framework of non-covalent contacts, including the interpretation of allostery, disease mutations and polymorphisms, by exploring individual subunits, interfaces, and protein-ligand contacts and by mapping external information. |
http://www.ncbi.nlm.nih.gov/pubmed/28087644 | What is opdivo? | Opdivo or nivolumab is a treatment for patients with unresectable or metastatic melanoma and disease progression following ipilimumab and, if BRAF V600 mutation positive, a BRAF inhibitor. |
http://www.ncbi.nlm.nih.gov/pubmed/24987179,http://www.ncbi.nlm.nih.gov/pubmed/30448580,http://www.ncbi.nlm.nih.gov/pubmed/28761134,http://www.ncbi.nlm.nih.gov/pubmed/22850463,http://www.ncbi.nlm.nih.gov/pubmed/26342684,http://www.ncbi.nlm.nih.gov/pubmed/24205431,http://www.ncbi.nlm.nih.gov/pubmed/25860498,http://www.ncbi.nlm.nih.gov/pubmed/22383310,http://www.ncbi.nlm.nih.gov/pubmed/21445621,http://www.ncbi.nlm.nih.gov/pubmed/24211676,http://www.ncbi.nlm.nih.gov/pubmed/28721824,http://www.ncbi.nlm.nih.gov/pubmed/29687202,http://www.ncbi.nlm.nih.gov/pubmed/30352242,http://www.ncbi.nlm.nih.gov/pubmed/26381129,http://www.ncbi.nlm.nih.gov/pubmed/16964766,http://www.ncbi.nlm.nih.gov/pubmed/29136946 | Has Hesperidin any role as a Neuroprotective Agent? | Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's diseaseHesperidin has been shown to have a role as a Neuroprotective Agenthesperidin attenuates depression-related symptoms in mice with mild traumatic brain injuryHesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury Neuroprotective Effects of Hesperidin on Cerebral Vasospasm |
http://www.ncbi.nlm.nih.gov/pubmed/22965147 | Are apoE mimetics being considered as a treatment against Alzheimer's disease? | Yes, apoE mimetics are being considered as a treatment against Alzheimer's disease, and they have been shown to protect AD mouse models against these AD-like features. |
http://www.ncbi.nlm.nih.gov/pubmed/29199013,http://www.ncbi.nlm.nih.gov/pubmed/28609185,http://www.ncbi.nlm.nih.gov/pubmed/30323550,http://www.ncbi.nlm.nih.gov/pubmed/27072905,http://www.ncbi.nlm.nih.gov/pubmed/29469601,http://www.ncbi.nlm.nih.gov/pubmed/30007591,http://www.ncbi.nlm.nih.gov/pubmed/29622939,http://www.ncbi.nlm.nih.gov/pubmed/30209441,http://www.ncbi.nlm.nih.gov/pubmed/30028313,http://www.ncbi.nlm.nih.gov/pubmed/29453668 | Which diseases are treated with netarsudil? | In 2 large, randomized, double-masked trials, once-daily dosing of netarsudil 0.02% was found to be effective and well tolerated for the treatment of patients with ocular hypertension and open-angle glaucoma. |
http://www.ncbi.nlm.nih.gov/pubmed/30324701,http://www.ncbi.nlm.nih.gov/pubmed/30298407,http://www.ncbi.nlm.nih.gov/pubmed/25637562,http://www.ncbi.nlm.nih.gov/pubmed/26517836,http://www.ncbi.nlm.nih.gov/pubmed/29360926,http://www.ncbi.nlm.nih.gov/pubmed/29042212 | Can you computationally predict Molecular Recognition Features (MoRFs) regions in Intrinsically Disordered Proteins (IDPs)? | Yes. There are various tools available in the literature that enable computational identification of Molecular Recognition Features (MoRFs) regions in intrinsically disordered protein sequences. |
http://www.ncbi.nlm.nih.gov/pubmed/29209918 | Which malignancies is Keytruda approved for before 2017? | Before 2017 Keytruda was approved for the treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma. |
http://www.ncbi.nlm.nih.gov/pubmed/29209918 | Which was the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body? | The first approved tumor treatment using a common biomarker rather than specified tumor locations in the body was Keytruda, which is a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. |
http://www.ncbi.nlm.nih.gov/pubmed/26242768 | What does Prevnar 13 consist of? | Prevnar 13 consists of 13 serotype-specific polysaccharides of Streptococcus pneumoniae (pneumococcus), each covalently conjugated to a non-toxic immunogenic carrier protein. |
http://www.ncbi.nlm.nih.gov/pubmed/27653758 | What is the route of administration of apixaban? | Apixaban is administered orally. |
http://www.ncbi.nlm.nih.gov/pubmed/27836978,http://www.ncbi.nlm.nih.gov/pubmed/26059840,http://www.ncbi.nlm.nih.gov/pubmed/30006057 | What is the cause of a STAG3 truncating variant? | Linkage analysis identified a locus on chromosome 7 where exome sequencing successfully identified a homozygous two base pair duplication (c.1947_48dupCT), leading to a truncated protein p.(Y650Sfs*22) in the STAG3 gene, confirming it as the cause of POI in this familyPrimary ovarian insufficiency (POI) is a distressing cause of infertility in young women. POI is heterogeneous with only a few causative genes having been discovered so far. Linkage analysis identified a locus on chromosome 7 where exome sequencing successfully identified a homozygous two base pair duplication (c.1947_48dupCT), leading to a truncated protein p.(Y650Sfs*22) in the STAG3 gene, confirming it as the cause of POI in this family. |
http://www.ncbi.nlm.nih.gov/pubmed/29186450,http://www.ncbi.nlm.nih.gov/pubmed/24436254,http://www.ncbi.nlm.nih.gov/pubmed/17119010 | Which tools have been developed for computing split-networks? | Split-networks are a generalization of phylogenetic trees that have proven to be a powerful tool in phylogenetics. Tools for computing such networks include SPECTRE, FlatNJ and QNet. |
http://www.ncbi.nlm.nih.gov/pubmed/22149316,http://www.ncbi.nlm.nih.gov/pubmed/16740622 | List 3 apoE mimetics. | COG133, COG112 and Ac-hE18A-NH(2) are apoE mimetics. |
http://www.ncbi.nlm.nih.gov/pubmed/30299483 | What are there sex differences in SAMHD1 activity? | The host restriction factor SAMHD1 exists in a hyperphosphorylated, less active state in male-derived macrophages. SAMHD1 is an essential modulator of infectivity in a sex-dependent manner in macrophages, constituting a novel component of sex differences in innate immune control of HIV-1. |
http://www.ncbi.nlm.nih.gov/pubmed/23332752 | Which enhancers are characterized as latent? | Here, we describe latent enhancers, defined as regions of the genome that in terminally differentiated cells are unbound by TFs and lack the histone marks characteristic of enhancers but acquire these features in response to stimulation.Latent enhancers are defined as regions of the genome that in terminally differentiated cells are unbound by TFs and lack the histone marks characteristic of enhancers but acquire these features in response to stimulation.Here, we describe latent enhancers, defined as regions of the genome that in terminally differentiated cells are unbound by TFshere, we describe latent enhancers, defined as regions of the genome that in terminally differentiated cells are unbound by tfs and lack the histone marks characteristic of enhancers but acquire these features in response to stimulation.Here , we describe latent enhancers , defined as regions of the genome that in terminally differentiated cells are unbound by TFs and lack the histone marks characteristic of enhancers but acquire these features in response to stimulation . |
http://www.ncbi.nlm.nih.gov/pubmed/16740622 | What is the difference between COG133 and COG112? | COG112 results from the fusion of COG133 to a protein transduction domain. |
http://www.ncbi.nlm.nih.gov/pubmed/9674897,http://www.ncbi.nlm.nih.gov/pubmed/26605035,http://www.ncbi.nlm.nih.gov/pubmed/16617304,http://www.ncbi.nlm.nih.gov/pubmed/15734119,http://www.ncbi.nlm.nih.gov/pubmed/8998528,http://www.ncbi.nlm.nih.gov/pubmed/25523123,http://www.ncbi.nlm.nih.gov/pubmed/12238021 | Velocardial facial syndrome, otherwise known as Di George syndrome is caused by a deletion in chromosome 21, yes or no? | Velocardial facial syndrome, otherwise known as Di George syndrome is caused by a deletion in chromosome 22.The deletion of chromosome 22q11.2 is involved in the majority of DiGeorge or velo-cardiofacial syndrome. |
http://www.ncbi.nlm.nih.gov/pubmed/25689697,http://www.ncbi.nlm.nih.gov/pubmed/27409832,http://www.ncbi.nlm.nih.gov/pubmed/28152543,http://www.ncbi.nlm.nih.gov/pubmed/27705916 | Is the protein Asporin related to disease? | Yes,
Accumulating evidence demonstrates the involvement of asporin in OA pathogenesis. Asporin has been reported as a tumor suppressor in breast cancer, while asporin-activated invasion has been described in gastric cancer. |
http://www.ncbi.nlm.nih.gov/pubmed/27111891,http://www.ncbi.nlm.nih.gov/pubmed/28408976,http://www.ncbi.nlm.nih.gov/pubmed/30086749,http://www.ncbi.nlm.nih.gov/pubmed/29990539,http://www.ncbi.nlm.nih.gov/pubmed/30241613,http://www.ncbi.nlm.nih.gov/pubmed/30374058,http://www.ncbi.nlm.nih.gov/pubmed/26862051,http://www.ncbi.nlm.nih.gov/pubmed/22495304,http://www.ncbi.nlm.nih.gov/pubmed/25959774 | Can TAD disruption lead to disease? | TAD boundaries are insulators of genomic neighborhoods. Τhe disruption of these structures by genomic rearrangements can result in gene misexpression and disease.We discuss how the disruption of these structures by genomic rearrangements can result in gene misexpression and disease. |
http://www.ncbi.nlm.nih.gov/pubmed/29245934 | Is L-4F an apoE mimetic peptide? | No, L-4F is an apoA-I mimetic peptide. |
http://www.ncbi.nlm.nih.gov/pubmed/24561791 | Which cells secrete lactotransferrin? | We conclude that lactotransferrin represents a late stage differentiation marker of neutrophils, macrophages and distinct subtypes of dendritic cells. |
http://www.ncbi.nlm.nih.gov/pubmed/29099642 | Which plant does oleuropein originate from? | Oleuropein originates from olive trees, and is specifically found in olive leaf extracts. |
http://www.ncbi.nlm.nih.gov/pubmed/29554826,http://www.ncbi.nlm.nih.gov/pubmed/29059618,http://www.ncbi.nlm.nih.gov/pubmed/30346831,http://www.ncbi.nlm.nih.gov/pubmed/27458609,http://www.ncbi.nlm.nih.gov/pubmed/27445482,http://www.ncbi.nlm.nih.gov/pubmed/28683596,http://www.ncbi.nlm.nih.gov/pubmed/28344579,http://www.ncbi.nlm.nih.gov/pubmed/29486600,http://www.ncbi.nlm.nih.gov/pubmed/28421429,http://www.ncbi.nlm.nih.gov/pubmed/23326187 | Reslizumab is a humanized monoclonal antibody to treat what specific type of asthma? | Reslizumab in the treatment of severe eosinophilic asthma: an update.Reslizumab is a humanized monoclonal antibody to treat eosinophilic asthma |
http://www.ncbi.nlm.nih.gov/pubmed/30385806,http://www.ncbi.nlm.nih.gov/pubmed/29581357,http://www.ncbi.nlm.nih.gov/pubmed/29051561 | What is the function of the protein Magt1? | The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium ([Mg2+]i) levels. |
http://www.ncbi.nlm.nih.gov/pubmed/29571746 | Can oleuropein aglycone interfere with amyloid aggregation? | Yes, oleuropein aglycone interferes in vitro and in vivo with amyloid aggregates. |
http://www.ncbi.nlm.nih.gov/pubmed/23211718,http://www.ncbi.nlm.nih.gov/pubmed/30323286 | What is the function of the transcriptional co-activator p300? | The transcriptional co-activator p300 is a histone acetyltransferase (HAT) that is typically recruited to transcriptional enhancers and regulates gene expression by acetylating chromatin. |
http://www.ncbi.nlm.nih.gov/pubmed/22274814 | What is another name for the plant Sideritis scardica? | Sideritis scardica is also known as ironwort or mountain tea. |
http://www.ncbi.nlm.nih.gov/pubmed/28880278,http://www.ncbi.nlm.nih.gov/pubmed/28956265,http://www.ncbi.nlm.nih.gov/pubmed/29483636,http://www.ncbi.nlm.nih.gov/pubmed/27351374 | How are gas vesicle proteins used in imaging? | Gas vesicles (GVs)-a unique class of gas-filled protein nanostructures-have recently been introduced as a promising new class of ultrasound contrast agents that can potentially access the extravascular space and be modified for molecular targeting.Gas vesicles (GVs)-a unique class of gas-filled protein nanostructures-have recently been introduced as a promising new class of ultrasound contrast agents that can potentially access the extravascular space and be modified for molecular targetingGas vesicles (GVs)-a unique class of gas-filled protein nanostructures-have recently been introduced as a promising new class of ultrasound contrast agents. |
http://www.ncbi.nlm.nih.gov/pubmed/28631214,http://www.ncbi.nlm.nih.gov/pubmed/25175164,http://www.ncbi.nlm.nih.gov/pubmed/26894970,http://www.ncbi.nlm.nih.gov/pubmed/30111043 | From where is gamabufotalin (GBT) isolated? | gamabufotalin (GBT) was isolated from toad venom. |
http://www.ncbi.nlm.nih.gov/pubmed/29754476 | What are super-enhancers | Super-enhancers are large clusters of enhancers covering the long region of regulatory DNA and are densely occupied by transcription factors, active histone marks, and co-activators. Accumulating evidence points to the critical role that super-enhancers play in cell type-specific development and differentiation, as well as in the development of various diseases. |
http://www.ncbi.nlm.nih.gov/pubmed/19756893,http://www.ncbi.nlm.nih.gov/pubmed/25914650,http://www.ncbi.nlm.nih.gov/pubmed/29229313,http://www.ncbi.nlm.nih.gov/pubmed/24721640 | Is Apelin usually decreased in diabetes? | Different studies in both animals and humans have shown that plasma apelin concentrations are usually increased during obesity and type 2 diabetes. |
http://www.ncbi.nlm.nih.gov/pubmed/30265292,http://www.ncbi.nlm.nih.gov/pubmed/21984067,http://www.ncbi.nlm.nih.gov/pubmed/20382757,http://www.ncbi.nlm.nih.gov/pubmed/28372543 | What is a mitosome? | Mitosomes are the simplest and the least well-studied type of anaerobic mitochondria. The mitosomes have abandoned typical mitochondrial traits such as the mitochondrial genome and aerobic respiration and their single role known to date is the formation of iron-sulfur clusters |
http://www.ncbi.nlm.nih.gov/pubmed/29764166 | What is the price of KYMRIAH treatment in 2019? | Kymriah, produced by Novartis has a price tag of US$475,000. |
http://www.ncbi.nlm.nih.gov/pubmed/26088338,http://www.ncbi.nlm.nih.gov/pubmed/20334617,http://www.ncbi.nlm.nih.gov/pubmed/17228860,http://www.ncbi.nlm.nih.gov/pubmed/30145372,http://www.ncbi.nlm.nih.gov/pubmed/1617622,http://www.ncbi.nlm.nih.gov/pubmed/22542640,http://www.ncbi.nlm.nih.gov/pubmed/18842591,http://www.ncbi.nlm.nih.gov/pubmed/24900364,http://www.ncbi.nlm.nih.gov/pubmed/30233375,http://www.ncbi.nlm.nih.gov/pubmed/20702404,http://www.ncbi.nlm.nih.gov/pubmed/1348618,http://www.ncbi.nlm.nih.gov/pubmed/30200251,http://www.ncbi.nlm.nih.gov/pubmed/16172019,http://www.ncbi.nlm.nih.gov/pubmed/27481247,http://www.ncbi.nlm.nih.gov/pubmed/18312275,http://www.ncbi.nlm.nih.gov/pubmed/19351152,http://www.ncbi.nlm.nih.gov/pubmed/27744189,http://www.ncbi.nlm.nih.gov/pubmed/28666740,http://www.ncbi.nlm.nih.gov/pubmed/25945707,http://www.ncbi.nlm.nih.gov/pubmed/2386542,http://www.ncbi.nlm.nih.gov/pubmed/22580100 | Human dihydroorotate dehydrogenase is a drug target and is involved in what biosynthetic pathway | Dihydroorotate dehydrogenase (DHODH) mediates the fourth step of de novo pyrimidine biosynthesisThe flavoenzyme dihydroorotate dehydrogenase (DHODH) catalyzes the fourth reaction of the de novo pyrimidine biosynthetic pathway, which exerts vital functions in the cells, especially within DNA and RNA biosynthesisDihydroorotate dehydrogenase (DHODH) catalyzes the fourth reaction of the de novo pyrimidine biosynthetic pathway, which exerts vital functions in the cells, especially within DNA and RNA biosynthesis. |
http://www.ncbi.nlm.nih.gov/pubmed/19474215,http://www.ncbi.nlm.nih.gov/pubmed/20942817 | List targets of classical analgesics. | Patient phenotypes in pharmacological pain treatment varies between individuals, which could be partly assigned to their genotypes regarding the targets of classical analgesics (OPRM1, PTGS2) |
http://www.ncbi.nlm.nih.gov/pubmed/29568381,http://www.ncbi.nlm.nih.gov/pubmed/30193156,http://www.ncbi.nlm.nih.gov/pubmed/30019087,http://www.ncbi.nlm.nih.gov/pubmed/29925947,http://www.ncbi.nlm.nih.gov/pubmed/30312531 | Is actin present in the nucleus? | Yes,
The revitalization of research into nuclear actin occurred after it was found that cellular stresses induce the nuclear localization and alter the structure of actin. |
http://www.ncbi.nlm.nih.gov/pubmed/29501911 | What is the indication for KYMRIAH? | Kymriah™ has been approved for the treatment of pediatric patients and young adults with refractory or relapse (R/R) B cell precursor acute lymphoblastic leukemia. |
http://www.ncbi.nlm.nih.gov/pubmed/30290178 | What is the effect of NFIA on astrocyte differentiation? | NFIA promotes astrocyte differentiation from neural precursor cells. |
http://www.ncbi.nlm.nih.gov/pubmed/27790001,http://www.ncbi.nlm.nih.gov/pubmed/24729685,http://www.ncbi.nlm.nih.gov/pubmed/22101760 | What is the mode of action for Tocilizumab? | Tocilizumab (TCZ) is a recombinant humanized monoclonal antibody against the IL-6 receptor and has been approved in many countries, including the United States, for the treatment of moderate to severe RA in patients who have not adequately responded to one or more disease-modifying antirheumatic drugs |
http://www.ncbi.nlm.nih.gov/pubmed/28666211,http://www.ncbi.nlm.nih.gov/pubmed/24869677,http://www.ncbi.nlm.nih.gov/pubmed/28748416,http://www.ncbi.nlm.nih.gov/pubmed/25516990,http://www.ncbi.nlm.nih.gov/pubmed/26801756 | Where is the protein protamine 2 expressed? | Human sperm express two types of protamine: protamine 1 (P1) and the family of protamine 2 (P2) proteins. |
http://www.ncbi.nlm.nih.gov/pubmed/30070328 | Can miR-122 target RUNX2? | Yes, miR-122 directly targets RUNX2. |
http://www.ncbi.nlm.nih.gov/pubmed/22431927,http://www.ncbi.nlm.nih.gov/pubmed/28401573,http://www.ncbi.nlm.nih.gov/pubmed/19882783,http://www.ncbi.nlm.nih.gov/pubmed/21949922,http://www.ncbi.nlm.nih.gov/pubmed/24286116,http://www.ncbi.nlm.nih.gov/pubmed/20979549,http://www.ncbi.nlm.nih.gov/pubmed/26751942,http://www.ncbi.nlm.nih.gov/pubmed/19368420,http://www.ncbi.nlm.nih.gov/pubmed/24741293,http://www.ncbi.nlm.nih.gov/pubmed/29495891,http://www.ncbi.nlm.nih.gov/pubmed/21234291 | Tocilizumab is an anti-TNF antibody, yes or no? | Tocilizumab (TCZ) is a humanized monoclonal antibody against IL-6 receptor licensed in 2009Tocilizumab (TCZ) is a humanized monoclonal antibody against IL-6 receptor licensed in 2009 that has demonstrated clinical efficacy in various adult RA populations.Tocilizumab (TCZ) is a humanized monoclonal antibody against IL-6 receptorwas treated with tocilizumab, an anti-interleukin-6 receptor monoclonal antibodyTocilizumab (TCZ) is a humanized monoclonal antibody against IL-6 receptor licensed in 2009 and recommendations consider TCZ as one of the treatements indicated after methotrexate and/or TNF inhibitors failure in adult RA. |
http://www.ncbi.nlm.nih.gov/pubmed/29783743,http://www.ncbi.nlm.nih.gov/pubmed/26154623,http://www.ncbi.nlm.nih.gov/pubmed/30290833,http://www.ncbi.nlm.nih.gov/pubmed/26598503 | Is it possible to analyze exosomes with FACS? | Yes,
a novel strategy for generating metabolically-labeled fluorescent exosomes that can be counted by flow cytometry assay (FACS) and characterized. |
http://www.ncbi.nlm.nih.gov/pubmed/30293207 | Which company developed opdivo? | Opdivo or nivolumab was developed by Bristol-Myers Squibb. |
http://www.ncbi.nlm.nih.gov/pubmed/22420649,http://www.ncbi.nlm.nih.gov/pubmed/20681888,http://www.ncbi.nlm.nih.gov/pubmed/27604908,http://www.ncbi.nlm.nih.gov/pubmed/28324149,http://www.ncbi.nlm.nih.gov/pubmed/7732491,http://www.ncbi.nlm.nih.gov/pubmed/25603037,http://www.ncbi.nlm.nih.gov/pubmed/25630309,http://www.ncbi.nlm.nih.gov/pubmed/27538766,http://www.ncbi.nlm.nih.gov/pubmed/25244345,http://www.ncbi.nlm.nih.gov/pubmed/25943001,http://www.ncbi.nlm.nih.gov/pubmed/25943002,http://www.ncbi.nlm.nih.gov/pubmed/22298075,http://www.ncbi.nlm.nih.gov/pubmed/24129128,http://www.ncbi.nlm.nih.gov/pubmed/23961667,http://www.ncbi.nlm.nih.gov/pubmed/18824833,http://www.ncbi.nlm.nih.gov/pubmed/30448932,http://www.ncbi.nlm.nih.gov/pubmed/25504789,http://www.ncbi.nlm.nih.gov/pubmed/24470443,http://www.ncbi.nlm.nih.gov/pubmed/23959574,http://www.ncbi.nlm.nih.gov/pubmed/9608316,http://www.ncbi.nlm.nih.gov/pubmed/28679392,http://www.ncbi.nlm.nih.gov/pubmed/12468815,http://www.ncbi.nlm.nih.gov/pubmed/23716132 | What are DMARDs? | To determine the utility of ultrasonography in guiding modification of disease-modifying anti-rheumatic drug (DMARD) and steroid therapy for inflammatory arthritis (IA)DMARDs are Disease Modifying anti-rheumatic drugs (DMARD).Treatment with disease-modifying antirheumatic drugs (DMARDs) was 61% (claims data)Treatment with disease-modifying antirheumatic drugs (DMARDs)Treatment with disease-modifying antirheumatic drugs (DMARDs) was 61% (claims data) and |
http://www.ncbi.nlm.nih.gov/pubmed/28287607,http://www.ncbi.nlm.nih.gov/pubmed/25766410 | What is the aim of the MitoCeption protocol? | The MitoCeption protocol directly and quantitatively transfer mitochondria, isolated from cell type A, to recipient cell type B. |
http://www.ncbi.nlm.nih.gov/pubmed/22045904 | Can prevnar 13 be used in children? | Yes, PCV13 is approved for routine vaccination of all infants as a 4-dose series at age 2, 4, 6, and 12-15 months for children who previously received 1 or more doses of the 7-valent pneumococcal conjugate vaccine (PCV7), and for children with underlying medical conditions that increase their risk for pneumococcal disease or its complications. |
http://www.ncbi.nlm.nih.gov/pubmed/28976302 | Was stelara developed by Amgen? | Stelara was developed by Janssen Pharmaceuticals, Inc., Horsham, PA, USA. |
http://www.ncbi.nlm.nih.gov/pubmed/29797711,http://www.ncbi.nlm.nih.gov/pubmed/28742259,http://www.ncbi.nlm.nih.gov/pubmed/29574922,http://www.ncbi.nlm.nih.gov/pubmed/30185361,http://www.ncbi.nlm.nih.gov/pubmed/18270863,http://www.ncbi.nlm.nih.gov/pubmed/28536935 | List off label uses for Rituximab. | Off label uses for rituximab are for poly- and dermatomyositis, multiple sclerosis, immune thrombocytopenia, systemic lupus erythematosus (SLE), lupus nephritis (LN), and other immune diseases. |
http://www.ncbi.nlm.nih.gov/pubmed/29362447,http://www.ncbi.nlm.nih.gov/pubmed/29335691 | Can mitochondria pass through membrane nanotubes? | Yes,
Membrane nanotubes (MNTs) act as "highways" between cells to facilitate the transfer of multiple signals and play an important role in many diseases. Our previous work reported on the transfer of mitochondria via MNTs between cardiomyocytes (CMs) and cardiac myofibroblasts (MFs). |
http://www.ncbi.nlm.nih.gov/pubmed/22825856,http://www.ncbi.nlm.nih.gov/pubmed/29130162,http://www.ncbi.nlm.nih.gov/pubmed/29095463,http://www.ncbi.nlm.nih.gov/pubmed/29130160,http://www.ncbi.nlm.nih.gov/pubmed/22269240,http://www.ncbi.nlm.nih.gov/pubmed/15151251,http://www.ncbi.nlm.nih.gov/pubmed/27634359,http://www.ncbi.nlm.nih.gov/pubmed/23125205,http://www.ncbi.nlm.nih.gov/pubmed/27688408,http://www.ncbi.nlm.nih.gov/pubmed/20819164 | What is Quorum Sensing in bacteria? | In many pathogenic microorganisms, communication systems, collectively termed quorum sensing (QS),In many pathogenic microorganisms, communication systems, collectively termed quorum sensing (QS), have been observedIn most bacteria, a global level of regulation, termed quorum sensing (QS), exists involving intercellular communication via the production and response to cell density-dependent signal molecules. |
http://www.ncbi.nlm.nih.gov/pubmed/29316812,http://www.ncbi.nlm.nih.gov/pubmed/28598007,http://www.ncbi.nlm.nih.gov/pubmed/29391017 | What is the cause of Krabbe disease? | Globoid cell leukodystrophy (GLD), or Krabbe disease, is an inherited, neurologic disorder that results from deficiency of a lysosomal enzyme, galactosylceramidase. |
http://www.ncbi.nlm.nih.gov/pubmed/22560515 | Name a CFL2 mutation which is associated with nemaline myopathy? | A mutation in CFL2 was identified in a family with nemaline myopathy, namely a homozygous missense mutation in exon 2 (c.19G>A, p.Val7Met). |
http://www.ncbi.nlm.nih.gov/pubmed/26339994,http://www.ncbi.nlm.nih.gov/pubmed/29177763,http://www.ncbi.nlm.nih.gov/pubmed/29414604,http://www.ncbi.nlm.nih.gov/pubmed/29243835,http://www.ncbi.nlm.nih.gov/pubmed/29486740,http://www.ncbi.nlm.nih.gov/pubmed/29204746,http://www.ncbi.nlm.nih.gov/pubmed/28866747 | What cellular process is the gene product of NANOG involved in? | NANOG is a transcription factor and a biomarker of cancer and pluripotent stem cells. |
http://www.ncbi.nlm.nih.gov/pubmed/24487281 | Name the uses of Sideritis scardica in traditional medicine. | Sideritis scardica is used in traditional medicine as a loosening agent in bronchitis and bronchial asthma; against the common cold and lung emphysema; in the treatment of inflammation, gastrointestinal disorders and coughs; and as an active constituent of dietary supplements for the prevention of anemia. Sideritis scardica has been attributed a broad range of properties such as antimicrobial, anti-inflammatory, cytotoxic, antioxidant, gastroprotective, antiglioma, and triple monoamine reuptake inhibition. |
http://www.ncbi.nlm.nih.gov/pubmed/20882035,http://www.ncbi.nlm.nih.gov/pubmed/24447602,http://www.ncbi.nlm.nih.gov/pubmed/12439898,http://www.ncbi.nlm.nih.gov/pubmed/28144274,http://www.ncbi.nlm.nih.gov/pubmed/29084544 | What are the phenotypic features of the autosomal dominant, development disease, Noonans syndrome | Noonan syndrome (NS) is an autosomal dominant disorder with vast heterogeneity in clinical and genetic features. Various symptoms have been reported for this abnormality such as short stature, unusual facial characteristics, congenital heart abnormalities, developmental complications, and an elevated tumor incidence rateNoonan syndrome is an autosomal dominant disease and is characterized by developmental problems. Symptoms have been reported for this abnormality such as short stature, unusual facial characteristics, congenital heart abnormalities, developmental complications, and an elevated tumor incidence rate |
http://www.ncbi.nlm.nih.gov/pubmed/29797354 | Are protamines ubiquitously expressed? | No,
Protamines are nuclear proteins which are specifically expressed in haploid male germ cells. |
http://www.ncbi.nlm.nih.gov/pubmed/28471166 | Are Crocus sativus compounds being considered against Alzheimer's disease? | Yes, it has been observed that Crocus sativus extracts and compounds have a positive effect against Alzheimer's disease. |
http://www.ncbi.nlm.nih.gov/pubmed/19645274,http://www.ncbi.nlm.nih.gov/pubmed/26824189,http://www.ncbi.nlm.nih.gov/pubmed/21722253,http://www.ncbi.nlm.nih.gov/pubmed/24149035,http://www.ncbi.nlm.nih.gov/pubmed/29217417,http://www.ncbi.nlm.nih.gov/pubmed/29079185 | Rickettsia felis was described as a human pathogen almost two decades ago, what is it's main arthropod vector? | Cat fleas (Ctenocephalides felis) carry Rickettsia felisCat fleas (Ctenocephalides felis) carrying Rickettsia felis and Bartonella species in Hong Kong.Cat fleas (Ctenocephalides felis) carrying Rickettsia felis and Bartonella species in Hong Kong |
http://www.ncbi.nlm.nih.gov/pubmed/29607687,http://www.ncbi.nlm.nih.gov/pubmed/26697860 | Are there any anti-amyloid antibody approved as drug for Alzheimer's disease treatment? | No new drugs have been approved during the past 15 years; and the available medications are not cost-effective. |
http://www.ncbi.nlm.nih.gov/pubmed/28471166 | Do Crocus sativus extracts loosen the blood-brain barrier? | No, in vitro and in vivo experiments show that the Crocus sativus extract increases the tightness of a cell-based blood-brain barrier (BBB). |
http://www.ncbi.nlm.nih.gov/pubmed/20234994,http://www.ncbi.nlm.nih.gov/pubmed/28406466 | Are artificial blood cells available? | No,
The critical point for the break through for artificial blood products did not come yet but could be ahead- |
http://www.ncbi.nlm.nih.gov/pubmed/25157031 | Have apolipoprotein mimetics been used in clinical trials? | Yes, apolipoprotein mimetics have entered clinical trials. |
http://www.ncbi.nlm.nih.gov/pubmed/24808249,http://www.ncbi.nlm.nih.gov/pubmed/29733009,http://www.ncbi.nlm.nih.gov/pubmed/30050644,http://www.ncbi.nlm.nih.gov/pubmed/18179629,http://www.ncbi.nlm.nih.gov/pubmed/28761463,http://www.ncbi.nlm.nih.gov/pubmed/25910623 | What are 2 organisms that can cause Human toxocariasis? | Human toxocariasis , a worldwide parasitic disease , is caused by the larval stage of intestinal nematodes of dogs and cats , namely Toxocara canis and Toxocara catiHuman toxocariasis, a worldwide parasitic disease, is caused by the larval stage of intestinal nematodes of dogs and cats, namely Toxocara canis and Toxocara catihuman toxocariasis, a worldwide parasitic disease, is caused by the larval stage of intestinal nematodes of dogs and cats, namely toxocara canis and toxocara cati |
http://www.ncbi.nlm.nih.gov/pubmed/26438538 | What is the dbSUPER database? | dbSUPER is the first integrated and interactive database of super-enhancers, with the primary goal of providing a resource for assistance in further studies related to transcriptional control of cell identity and disease. dbSUPER provides a responsive and user-friendly web interface to facilitate efficient and comprehensive search and browsing. The data can be easily sent to Galaxy instances, GREAT and Cistrome web-servers for downstream analysis, and can also be visualized in the UCSC genome browser where custom tracks can be added automatically. The data can be downloaded and exported in variety of formats. Furthermore, dbSUPER lists genes associated with super-enhancers and also links to external databases such as GeneCards, UniProt and Entrez. dbSUPER also provides an overlap analysis tool to annotate user-defined regions. |
http://www.ncbi.nlm.nih.gov/pubmed/25777539,http://www.ncbi.nlm.nih.gov/pubmed/23370538,http://www.ncbi.nlm.nih.gov/pubmed/24627166,http://www.ncbi.nlm.nih.gov/pubmed/19819962,http://www.ncbi.nlm.nih.gov/pubmed/23894587 | List places in the body where somatostatin is produced. | Somatostatin is a cyclic peptide well known for its strong regulatory effects throughout the body. Also known by the name of growth hormone inhibiting hormone, it is produced in many locations, which include the olfactory bulb, hair follicles, pancreas, retina, and central nervous system (CNS). |
http://www.ncbi.nlm.nih.gov/pubmed/29633730,http://www.ncbi.nlm.nih.gov/pubmed/29435292,http://www.ncbi.nlm.nih.gov/pubmed/29046997 | Is the Philadelphia chromosome a fusion between parts of chromosomes 1 and 9? | No,
Chronic myeloid leukemia is a stem cell disease with the presence of Philadelphia chromosome generated through reciprocal translocation of chromosome 9 and 22. |
http://www.ncbi.nlm.nih.gov/pubmed/29501911 | What is YESCARTA? | Yescarta is an autologous chimeric antigen receptor (CAR) T cell therapy approved by the FDA. Yescarta™ is approved for the treatment of adult patients with R/R large B cell lymphoma. It is a CD19-specific CAR T cell therapy lysing CD19-positive targets. |
http://www.ncbi.nlm.nih.gov/pubmed/28586632 | What are the 3 types of immunoglobulin heavy chain containing antibodies found in human breast milk? | IgA, IgG, AND IgM can be found in human milk. |
http://www.ncbi.nlm.nih.gov/pubmed/28836271,http://www.ncbi.nlm.nih.gov/pubmed/28494612,http://www.ncbi.nlm.nih.gov/pubmed/29676625,http://www.ncbi.nlm.nih.gov/pubmed/29169635,http://www.ncbi.nlm.nih.gov/pubmed/29377341 | What is a exposome? | The exposome is a novel conceptual framework that allows for concurrent examination of multiple intrinsic and extrinsic factors, including environmental exposures, as well as changes in exposures over time, to elucidate the complex environmental factors that affect health outcomes. |
http://www.ncbi.nlm.nih.gov/pubmed/29625577 | What does the strimvelis treatment consist of? | Strimvelis consists of autologous CD34+ cells transduced to express adenosine deaminase [ADA]. |
http://www.ncbi.nlm.nih.gov/pubmed/28961712 | Can therapeutic levels of Vedolizumab be found in the breast milk of nursing mothers following treatment for Inflammatory bowel disease? | vedolizumab can be detected in the breast milk of nursing mothers. although more data are imperative, the concentrations of vedolizumab in breast milk are minute and are therefore unlikely to result in systemic or gastro-intestinal immune-suppression of the infant.Vedolizumab is barely detectable in the breast milk of nursing mothers. measurements in breast milk after an infusion of the drug showed that levels did not surpass 480 ng/ml, which was roughly 1/100 of the comparable serum levels.Vedolizumab can be detected in the breast milk of nursing mothers .
Although more data are imperative , the concentrations of vedolizumab in breast milk are minute and are therefore unlikely to result in systemic or gastro-intestinal immune-suppression of the infant .Vedolizumab can be detected in the breast milk of nursing mothers. Although more data are imperative, the concentrations of vedolizumab in breast milk are minute and are therefore unlikely to result in systemic or gastro-intestinal immune-suppression of the infant. |
http://www.ncbi.nlm.nih.gov/pubmed/30373828 | What is predicted using SURFY? | surfaceome predictor SURFY, based on machine learning. |
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