prognosis/cardio-docs-qa · Datasets at Hugging Face

Where is Li Ka Shing Knowledge Institute based?

St. Michael’s Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Li Ka Shing Knowledge Institute based?. ### Response: St. Michael’s Hospital.

What is the title of the Assistant Professor at the University of Toronto?

Department of Anesthesia and Institute of Health Policy Management and Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Assistant Professor at the University of Toronto?. ### Response: Department of Anesthesia and Institute of Health Policy Management and Evaluation.

What is another name for the Heart and Stroke Foundation of Canada?

CIHR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for the Heart and Stroke Foundation of Canada?. ### Response: CIHR.

What does PCORI stand for?

DSMB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PCORI stand for?. ### Response: DSMB.

What is the name of the organization that records the relationships of reviewers with industry and other entities?

Myers Squib

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that records the relationships of reviewers with industry and other entities?. ### Response: Myers Squib.

What percentage of a business is owned by a person who has a significant interest in it?

≥ 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of a business is owned by a person who has a significant interest in it?. ### Response: ≥ 5%.

How much of the business does the person have a substantial interest in?

≥ 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the business does the person have a substantial interest in?. ### Response: ≥ 5%.

What type of peptide is NT-proBNP?

N -terminus pro -B-type natriuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of peptide is NT-proBNP?. ### Response: N -terminus pro -B-type natriuretic.

What is B-type natriuretic Peptide?

BNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is B-type natriuretic Peptide?. ### Response: BNP.

How many thresholds are there?

978 -1-4731

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What peptides are most accurate in identifying heart failure?

N -terminus pro -B-type natriuretic peptide (NT -proBNP) and B-type natriuretic peptide (BNP)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What peptides are most accurate in identifying heart failure?. ### Response: N -terminus pro -B-type natriuretic peptide (NT -proBNP) and B-type natriuretic peptide (BNP).

What is the reference standard for NT-proBNP?

N -terminus pro -B-type natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reference standard for NT-proBNP?. ### Response: N -terminus pro -B-type natriuretic peptide.

What is the area under Curve 5 Diagnostic RCT?

ROC curve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the area under Curve 5 Diagnostic RCT?. ### Response: ROC curve.

What are the clinical and cost effectiveness of N -terminus pro -B-type natriuretic peptide?

when each is followed by the appropriate patient pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the clinical and cost effectiveness of N -terminus pro -B-type natriuretic peptide?. ### Response: when each is followed by the appropriate patient pathway.

What is natriuretic peptide (BNP) used for?

improve patient outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is natriuretic peptide (BNP) used for?. ### Response: improve patient outcomes.

What are the Efficacy outcomes of BNP?

All-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Efficacy outcomes of BNP?. ### Response: All-cause mortality.

How many people receive echocardiography?

Number

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people receive echocardiography?. ### Response: Number.

What is another term for people who may not have needed echocardiography?

false positive results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for people who may not have needed echocardiography?. ### Response: false positive results.

What are the secondary outcomes of echocardiographic testing?

Sensitivity / specificity and other test accuracy measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the secondary outcomes of echocardiographic testing?. ### Response: Sensitivity / specificity and other test accuracy measures.

What is the clinical and cost effectivenes s of cardiac MRI followed by the appropriate patient pathway?

In people with heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical and cost effectivenes s of cardiac MRI followed by the appropriate patient pathway?. ### Response: In people with heart failure.

What are the critical outcomes?

All-cause mortality (time to event)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the critical outcomes?. ### Response: All-cause mortality (time to event).

How long is the health-related quality of life?

12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the health-related quality of life?. ### Response: 12.

How long is the quality of life at 12 months?

continuous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the quality of life at 12 months?. ### Response: continuous.

What is the term for unplanned hospitalisation?

Count rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for unplanned hospitalisation?. ### Response: Count rate.

Adverse events related to test?

non -specific fibrosis in the presence of renal dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adverse events related to test?. ### Response: non -specific fibrosis in the presence of renal dysfunction.

Reclassification of specific HF aetiology includes ability to classify previous unclassified patients?

Adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Reclassification of specific HF aetiology includes ability to classify previous unclassified patients?. ### Response: Adverse events.

What is specific HF aetiology?

ability to classify previous unclassified patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is specific HF aetiology?. ### Response: ability to classify previous unclassified patients.

What is the ability to classify previous unclassified patients?

HF aetiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ability to classify previous unclassified patients?. ### Response: HF aetiology.

What is the clinical and cost effectiveness of salt and/or fluid restriction in people with heart failure?

Repeat testing / additional testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical and cost effectiveness of salt and/or fluid restriction in people with heart failure?. ### Response: Repeat testing / additional testing.

How long is the quality of life at 12 months (Continuous)?



Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the quality of life at 12 months (Continuous)?. ### Response: .

What did Hall G, Heimdahl A, Nord CE, do after dental extraction?

prophylactic administration ofcefaclor on transient bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Hall G, Heimdahl A, Nord CE, do after dental extraction?. ### Response: prophylactic administration ofcefaclor on transient bacteremia.

What was the effect of prophylactic administration ofcefaclor on?

transient bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of prophylactic administration ofcefaclor on?. ### Response: transient bacteremia.

When was the Eur J ClinMicrobiol Infect Dis 15:646–649.78?

1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur J ClinMicrobiol Infect Dis 15:646–649.78?. ### Response: 1995.

What is the role of antiseptics and antibiotics in post-extraction bacter-aemia?

role

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of antiseptics and antibiotics in post-extraction bacter-aemia?. ### Response: role.

What is Oliver R, Roberts GJ, Hooper L. Penicillins for the prophylaxis of bacterial endocarditis in dentistry?

cost-effective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Oliver R, Roberts GJ, Hooper L. Penicillins for the prophylaxis of bacterial endocarditis in dentistry?. ### Response: cost-effective.

How important are dental procedures as a cause ofinfective endocarditis?

Estimated risk of endocarditis in adults with predisposingcardiac conditions undergoing dental procedures with or without anti-biotic prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How important are dental procedures as a cause ofinfective endocarditis?. ### Response: Estimated risk of endocarditis in adults with predisposingcardiac conditions undergoing dental procedures with or without anti-biotic prophylaxis.

What year did Am J Cardiol 54:797–801.82?

1984

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am J Cardiol 54:797–801.82?. ### Response: 1984.

Where was Medicine (Baltimore) published in 1977?

56:61–77.83

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was Medicine (Baltimore) published in 1977?. ### Response: 56:61–77.83.

Horstkotte D, Rosin H, Friedrichs W, Loogen F. Contribution forchoosing the optimal prophylaxis of what?

bacterial endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Horstkotte D, Rosin H, Friedrichs W, Loogen F. Contribution forchoosing the optimal prophylaxis of what?. ### Response: bacterial endocarditis.

What was Loogen F's role in choosing the optimal prophylaxis of bacterial endocarditis?

Contribution

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Loogen F's role in choosing the optimal prophylaxis of bacterial endocarditis?. ### Response: Contribution.

What is the name of the study that evaluated protective efficacy?

Am J Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated protective efficacy?. ### Response: Am J Med.

In what year was the Am J Med published?

1990

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Am J Med published?. ### Response: 1990.

Who was the author of The Epidemiology of Bacterial Endocarditic Disease?

enburg HA, Michel MF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of The Epidemiology of Bacterial Endocarditic Disease?. ### Response: enburg HA, Michel MF.

What is the epidemiology of bacterial endocarditis in The Netherlands?

II: antecedent pro-cedures and use of prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the epidemiology of bacterial endocarditis in The Netherlands?. ### Response: II: antecedent pro-cedures and use of prophylaxis.

What are the antecedent pro-cedures and use of prophylaxis?

Epidemi-ology of bacterial endocarditis in The Netherlands, II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the antecedent pro-cedures and use of prophylaxis?. ### Response: Epidemi-ology of bacterial endocarditis in The Netherlands, II.

When was the Arch Intern Med published?

1992

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Arch Intern Med published?. ### Response: 1992.

What is a prophylaxis for prevention of?

bacterial endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prophylaxis for prevention of?. ### Response: bacterial endocarditis.

What is the name of the disease that causes native-valve endocarditis?

bacterial endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes native-valve endocarditis?. ### Response: bacterial endocarditis.

What is the risk of endocarditis in adults with predisposingcardiac conditions undergoing dental procedures with or without anti-biotic prophylaxis?

Estimated risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of endocarditis in adults with predisposingcardiac conditions undergoing dental procedures with or without anti-biotic prophylaxis?. ### Response: Estimated risk.

What was the “incubation period” of sub-acute bacterial infection?

Post-extraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the “incubation period” of sub-acute bacterial infection?. ### Response: Post-extraction.

Durack D, Beeson P. What is the “incubation period” of sub-acute bacterial endocarditis?

Clin Infect Dis . 2006;42:e102–e107.89

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Durack D, Beeson P. What is the “incubation period” of sub-acute bacterial endocarditis?. ### Response: Clin Infect Dis . 2006;42:e102–e107.89.

What year did Yale J Biol Med publish 50:49–58.90?

1977

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Yale J Biol Med publish 50:49–58.90?. ### Response: 1977.

Steckelberg JM, Wilson WR. Risk factors for what?

infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Steckelberg JM, Wilson WR. Risk factors for what?. ### Response: infective endocarditis.

Pallasch TJ, Wahl MJ. Focal infection: new age or ancient history?

new

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pallasch TJ, Wahl MJ. Focal infection: new age or ancient history?. ### Response: new.

What year did Endodontic Topics publish?

2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Endodontic Topics publish?. ### Response: 2003.

What is the name of the journal that examined the history of endodontics in 2003?

Endodontic Topics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that examined the history of endodontics in 2003?. ### Response: Endodontic Topics.

How many people died from anaphylactic shock in 1968?

38:159–188.93

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people died from anaphylactic shock in 1968?. ### Response: 38:159–188.93.

When was the Bull World Health Organ published?

1968

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Bull World Health Organ published?. ### Response: 1968.

What year was Allergy.39:151–164.94?

1984

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Allergy.39:151–164.94?. ### Response: 1984.

What is the cost-effectiveness of antibiotic prophylaxis for bac-terial endocarditis?

Efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of antibiotic prophylaxis for bac-terial endocarditis?. ### Response: Efficacy.

What is the level of evidence for statins in NSTE-ACS patients?

C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for statins in NSTE-ACS patients?. ### Response: C.

How long after presentation is it reasonable to obtain a fasting lipid profile?

24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after presentation is it reasonable to obtain a fasting lipid profile?. ### Response: 24 hours.

What does statin therapy reduce?

the rate of recurrent MI, coronary heart disease mortality, need for myocardial revascularization, and stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does statin therapy reduce?. ### Response: the rate of recurrent MI, coronary heart disease mortality, need for myocardial revascularization, and stroke.

MI, need for myocardial revascularization, and stroke?

coronary heart disease mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: MI, need for myocardial revascularization, and stroke?. ### Response: coronary heart disease mortality.

High-risk patients, such as those with NSTE-ACS, derive more benefit from what?

high-intensity statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High-risk patients, such as those with NSTE-ACS, derive more benefit from what?. ### Response: high-intensity statins.

What lowers low-density lipoprotein cholesterol levels by 50%?

atorvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What lowers low-density lipoprotein cholesterol levels by 50%?. ### Response: atorvastatin.

What is PROVE IT-TIMI 22?

Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PROVE IT-TIMI 22?. ### Response: Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction.

What is MIRACL?

Myocardial Ischemia Reduction With Acute Cholesterol Lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MIRACL?. ### Response: Myocardial Ischemia Reduction With Acute Cholesterol Lowering.

What can early introduction of this approach promote?

improved compliance with this regimen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can early introduction of this approach promote?. ### Response: improved compliance with this regimen.

What should be started and continued indefinitely in all patients with LVEF less than 0.40?

ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be started and continued indefinitely in all patients with LVEF less than 0.40?. ### Response: ACE inhibitors.

What is recommended in patients with HF or MI with LVEF less than 0.40 who are ACE inhibitor in-tolerant?

ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with HF or MI with LVEF less than 0.40 who are ACE inhibitor in-tolerant?. ### Response: ARBs.

What is recommended in patients post-MI without renal dysfunction or hyperkalemia?

Aldosterone blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients post-MI without renal dysfunction or hyperkalemia?. ### Response: Aldosterone blockade.

What is the LVEF 0.40 or less?

diabetes mellitus, or HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LVEF 0.40 or less?. ### Response: diabetes mellitus, or HF.

What is the level of evidence that ARBs are reasonable in other patients with cardiac or other vascular disease who are ACE inhibitor in-tolerant?

280

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence that ARBs are reasonable in other patients with cardiac or other vascular disease who are ACE inhibitor in-tolerant?. ### Response: 280.

What may be reasonable in all other patients with cardiac or other vascular disease?

ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable in all other patients with cardiac or other vascular disease?. ### Response: ACE inhibitors.

What does ACE inhibitors reduce mortality in patients with recent MI?

LV dysfunction (LVEF <0.40) with or without pulmonary congestion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACE inhibitors reduce mortality in patients with recent MI?. ### Response: LV dysfunction (LVEF <0.40) with or without pulmonary congestion.

What percentage of patients with NSTEMI develop HF during hospitalization?

15%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with NSTEMI develop HF during hospitalization?. ### Response: 15%.

What is the rate of HF in patients with diabetes mellitus 1 year later?

24%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of HF in patients with diabetes mellitus 1 year later?. ### Response: 24%.

How much benefit did a metaanalysis show from early initiation of an ACE inhibitor?

0.48%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much benefit did a metaanalysis show from early initiation of an ACE inhibitor?. ### Response: 0.48%).

How long after admission for AMI was the benefit seen?

24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after admission for AMI was the benefit seen?. ### Response: 24 hours.

What should be used cautiously?

An ACE inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used cautiously?. ### Response: An ACE inhibitor.

What should be used cautiously in the Downloaded from http://ahajournals.org by on April 28, 2023?

An ACE inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used cautiously in the Downloaded from http://ahajournals.org by on April 28, 2023?. ### Response: An ACE inhibitor.

What should be provided to maintain oxygen saturation >94%?

Supplemental oxygen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be provided to maintain oxygen saturation >94%?. ### Response: Supplemental oxygen.

What is not recommended in nonhypoxic patients hospitalized with AIS?

Supplemental oxygen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in nonhypoxic patients hospitalized with AIS?. ### Response: Supplemental oxygen.

Why was No BenefitB-RRecommendation reworded?

for clarity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was No BenefitB-RRecommendation reworded?. ### Response: for clarity.

What year was the 2013 AIS Guidelines reworded?

2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the 2013 AIS Guidelines reworded?. ### Response: 2015.

What year were COR and LOE amended to conform with the 2015 Recommendation Classification System?

2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year were COR and LOE amended to conform with the 2015 Recommendation Classification System?. ### Response: 2013.

How many participants were randomized within 24 hours of admission to the 2013 AIS Guidelines?

8003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were randomized within 24 hours of admission to the 2013 AIS Guidelines?. ### Response: 8003.

What was the baseline O2 saturation at 90 days of oxygen by nasal cannula at 2 L/min?

>93%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the baseline O2 saturation at 90 days of oxygen by nasal cannula at 2 L/min?. ### Response: >93%).

How long did it take for a participant to breathe continuously for 72 hours?

2 L/min (baseline O2 saturation >93%) or 3 L/min (baseline O2 saturation ≤93%) continuously for 72 hours or nocturnally for 3 nights

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for a participant to breathe continuously for 72 hours?. ### Response: 2 L/min (baseline O2 saturation >93%) or 3 L/min (baseline O2 saturation ≤93%) continuously for 72 hours or nocturnally for 3 nights.

What is the baseline O2 saturation?

>93%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the baseline O2 saturation?. ### Response: >93%).

How long is 3 L/min continuously for 72 hours or nocturnally for 3 nights?

2 L/min (baseline O2 saturation >93%) or 3 L/min (baseline O2 saturation ≤93%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is 3 L/min continuously for 72 hours or nocturnally for 3 nights?. ### Response: 2 L/min (baseline O2 saturation >93%) or 3 L/min (baseline O2 saturation ≤93%).

When was the online Data Supplement 1 downloaded?

April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the online Data Supplement 1 downloaded?. ### Response: April 28, 2023.

Potency, receptor-binding characteristics, tissue distribution,metabolism, and excretion properties are what?

there is little evidencethat these differences are associated with therapeutic advan-tages

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Potency, receptor-binding characteristics, tissue distribution,metabolism, and excretion properties are what?. ### Response: there is little evidencethat these differences are associated with therapeutic advan-tages.

The benefits of ACE inhibitors seem to reflect what class effect?

BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The benefits of ACE inhibitors seem to reflect what class effect?. ### Response: BP.

What can the selection of a particular agent be based on?

availability in local formularies, cost, andtolerability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can the selection of a particular agent be based on?. ### Response: availability in local formularies, cost, andtolerability.

What is recommended for all patients with SIHD and hypertension?

ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for all patients with SIHD and hypertension?. ### Response: ACE inhibitors.

What are ACE inhibitors recommended for?

all patients withSIHD and hypertension, diabetes mellitus, LV dysfunction(EF /H1134940%), or CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ACE inhibitors recommended for?. ### Response: all patients withSIHD and hypertension, diabetes mellitus, LV dysfunction(EF /H1134940%), or CKD.

Who were participants in the HOPE301 orEUROPA296trials?

participants who did not have one ofthese conditions but did have multiple cardiac risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were participants in the HOPE301 orEUROPA296trials?. ### Response: participants who did not have one ofthese conditions but did have multiple cardiac risk factors.

What do ARBs do in a competitive or insurmountable manner to thetype 1 angiotensin II receptor?

bind

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ARBs do in a competitive or insurmountable manner to thetype 1 angiotensin II receptor?. ### Response: bind.