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A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 0.25-16.0, Dengue Disease Progression Age >3 months and <16 years Clinical suspicion of dengue hemorrhagic fever. (Revised WHO Classification System) Not a prisoner or ward of the state Parents able and willing to give consent. Children older then 7 able and willing to give assent Allergic to Ultrasound gel Prisoners or wards of the state Unstable patients Known pleural effusion, ascites, or gallbladder wall thickening | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Hip Pain Patients undergoing surgery for painful external snapping hip years or older Inability to comply with the protocol (e.g. due to dementia) | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 15.0-999.0, Postoperative Pain Elective minimally invasive surgical correction of funnel chest (pectus excavatum age ≥15 years Previous thoracic surgical interventions Presence of diseases affecting the central and/or peripheral nervous system Presence of chronic pain conditions Inability to speak and/or understand Danish Inability to understand and participate in the experimental pain session Presence of psychiatric disorders History of frostbite in the non-dominant upper limb Presence of sores or cuts on non-dominant upper limb Presence of cardiovascular disease History of fainting and/or seizures | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 21.0-85.0, Ischemic Stroke Patients 21-85 years old, male or female Suspected acute ischemic stroke based on clinical and radiographic evidence as determined and documented by the Stroke Neurology team at University of Kentucky Patients must meet for intra-arterial thrombolysis as determined and documented by Interventional Neuroradiology attending physician (JF or AA) Patients must have an acute thromboembolus within an intracranial artery (internal carotid, anterior cerebral, middle cerebral, posterior cerebral, basilar, vertebral) which undergoes pharmacologic (tissue plasminogen activator tPA) and/or mechanical (eg. Merci or Penumbra clot retrieval) thrombolysis Patients with impaired capacity may be included, as the pathology to be studied (stroke) may impair their capacity (please see attached required documentation regarding impaired capacity) Patients must have a TICI 2A or better revascularization via intra-arterial thrombolysis For reference, the TICI Scale is defined below = No Perfusion = Perfusion past the initial obstruction but limited distal branch filling with little or slow distal perfusion Pregnant women (would not qualify for intra-arterial thrombolysis as standard of care) Patients who undergo intra-arterial thrombolysis for acute stroke, in whom only TICI 0 or 1 revascularization is obtained Patients with occlusion of the cervical common or internal carotid artery will be excluded from the study | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Venous Thromboembolism Patients aged 18 years or older with an objectively verified diagnosis of DVT and/or PE and treated according to routine clinical practice with Rivaroxaban Patients in whom follow-up is unlikely or impossible Patients unable to give consent Patients who receive heparin therapy for more than 48 hours Patients who receive more than one dose of warfarin Patients with an indication for anticoagulation other than DVT and/or PE All contraindications listed in the local product information (SmPC) will form part of the | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Venous Thrombosis Pulmonary Embolism Lung Neoplasms Patient At least 18 years of age Either gender Diagnosed with resectable lung cancer or metastatic lung disease eligible to complete metastasectomy Undergoing one of the following surgeries: Segmentectomy, wedge resection, lobectomy, bilobectomy or pneumonectomy Competent to understand and sign consent documents Patient Known allergic or anaphylactic reaction to contrast dye, heparin or low molecular weight heparin (LMWH) Under current anticoagulation for venous thromboembolism or other medical conditions Known renal impairment, defined as creatinine clearance value of less than 55ml/min/m2 as calculated by the Cockroft-Gault method History of, or ongoing liver disease, manifested as ascites or previous peritoneal tapping for ascites Pregnant or planning to become pregnant Diagnosed or treated for VTE in the past 3 months prior to surgery Present or previous increase risk of haemorrhage History of previous HIT (heparin induced thrombocytopenia) Platelet count must be below 75,000 Previously inserted Inferior Vena Cava Filter (IVC) filter | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 0.0-999.0, Venous Thromboembolism all patients undergone primary total knee arthroplasty renal insufficiency, contrast allergy, simultaneous bilateral TKA, hemorrhagic disorder, sever liver disease | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pain, Postoperative Anesthesia, Conduction Arthroplasty, Replacement, Hip Primary total hip replacement general anaesthesia Allergy to local anesthetics of the amide type Revision surgery Bilateral surgery Chronic pain patient Women in the fertile age | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Venous Thromboembolism Lung Neoplasms Pulmonary Embolism Patients must be at least 18 years of age Patient may be of either gender Patients must be diagnosed with resectable lung cancer or metastatic lung disease eligible to complete metastasectomy Patients must be undergoing one of the following surgeries: Segmentectomy, wedge resection, lobectomy, bilobectomy or pneumonectomy Patients must be competent to understand consent documents All patients with known allergic or anaphylactic reaction to contrast dye, heparin or low molecular weight heparin (LMWH) Patients must not be under current anticoagulation for venous thromboembolism or other medical conditions Patients must not have known renal impairment (defined as estimated glomerular filtration rate of less than 30ml/min/m2 as calculated by the Cockcroft-Gault method) either pre-operatively or as identified based on blood work obtained prior to the scheduled 30-day post-operative scan Patients must not have known hepatic failure, with international normalized ratio (INR) of >1.5 Patients with history of, or ongoing liver disease, manifested as ascites or previous peritoneal tapping for ascites Patients must not be pregnant or planning to become pregnant Patients must not have been diagnosed or treated for VTE in the past 3 months prior to surgery Patients must not have a known, objectively confirmed bleeding disorder Patients must not have a present or previous increase risk of haemorrhage Patients must not have a history of previous heparin induced thrombocytopenia | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Pulmonary Embolism, diagnosed by CTA or high probability VQ Scan Total Pulmonary Embolism Severity Index (PESI) score <86 Massive Pulmonary Embolism: Hypotension with signs of right heart strain on CTA or Echocardiogram Sustained Systolic Blood Pressure (SBP) <95 mmHg during Emergency Department or observation stay Age <18 Pregnant Renal insufficiency (Creatinine Clearance <30) Hepatic Dysfunction (AST/ALT/ALP > 3 times upper limit of normal) Unreliable social situation or inability to follow up Contraindication to enoxaparin, warfarin and rivaroxaban Atrial or ventricular dysrhythmia(s) | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Concern for PE by attending physician and CTPA ordered If patient is under the age of 18, a prisoner, or a ward of the state CTPA ordered but not performed | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Emergency Patients Acute onset of, or worsening of dyspnea Or chest pain Low clinical pretest probability of PE, empiricially estimated by the gestalt Other obvious cause than PE for dyspnea or chest pain Acute severe presentation Contra-indication to CTPA Concurrent anticoagulation treatment Current diagnosed thrombo-embolic event Inability to follow up Prisoners Pregnancy No social security Participation in another intervention trial | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-65.0, Pleural and Lung Ultrasound Twenty healthy male volunteers aged between 18 and 65 years-old with no history of respiratory or cardiovascular pathologies will be enrolled Females and all subjects with history of respiratory or cardiovascular diseases will be excluded | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Venous Thromboembolism Deep Venous Thrombosis Pulmonary Embolism All patients on the four trial floors who miss at least one dose of VTE prophylaxis will be included in the study | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-85.0, Postoperative Pain Patients undergoing unilateral THR and TKR who are between the ages of 18 and 85 regardless of the anesthesia and postoperative analgesia type Patients participating in other studies may participate in this study as well Patients with Motor Activity Assessment Scale (MAAS) Score of 3 and 4 Age <18, >85 History of chronic pain as defined by use of long acting opioid medication > 6 months duration MAAS Score of <3 and >4 Anticholinergic agent use Patients with the following conditions Autonomic neuropathy Pacemaker/AICD Burn patients or patients with severe dermatologic conditions (as defined by skin conditions causing further pain to patients that actively has to be treated) Allergy to adhesive tape Communication barriers | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Anticoagulation For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com Patients aged 18 or older over the study period Patients with a diagnosis for NVAF or VTE anytime in their medical records Patients having at least one year of enrolment in the database prior to the index date Patients newly initiated with VKA during the study period (index date) Patients with a diagnosis for both NVAF and VTE anytime in their medical records | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 14.0-40.0, Groin Pain Diagnosis of athletic groin pain Professional athlete in full time training with groin pain diagnosis Post infective osteitis Bone tumour Acute injury | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Orthopaedic Decision Making Patients 18 year old or older daily smoker patients within 1 week post orthopaedic operation patient that have never received an orthopaedic related smoking cessation discussion Younger than 18 patients unable to provide consent patients that suffer from auditory/visual/mental disability requiring another individual as a decision-maker patients in severe acute pain | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Stroke Ischemic Stroke Eligible patients will be Adults (≥18years) with the final diagnosis of an acute ischemic stroke CT-Angiogram proven, large artery occlusion (LAO) in the internal carotid artery (ICA), middle cerebral artery (MCA -M1 or M2 site) locations NIH Stroke Scale ≥6 (NIHSS) OR proven LAO on imaging (must be from designated LAO listed on #2) LSN (last seen normal) to groin puncture (≤ 8 hours) in thrombectomy arm; LSN to presentation to endovascular capable center (≤ 8 hours) in medical arm Baseline modified Rankin Scale score of 0-3 Signed Informed Consent obtained Subject willing to comply with the protocol follow-up requirements Anticipated life expectancy of at least 3 months IV-tPA eligible patients must meet AHA guidelines Patients are excluded if Inability to undergo CT-Angiography and/or CT-Perfusion imaging (e.g., renal insufficiency, iodine/contrast allergy) Co-morbid psychiatric or medical illnesses that would confound the neurological assessments | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 50.0-80.0, Osteoarthritis, Knee End-stage arthritis of the knee Failure of medical treatment or rehabilitation Hemoglobin > 10g/dl No use of non-steroid anti-inflammatory agent one week before operation Preoperative Hemoglobin ≦10 g/dl History of infection or intraarticular fracture of the affective knee Renal function deficiency (GFR < 55 ml/min/1.73m2)which is relative contraindicated for venography Elevated liver enzyme, history of liver cirrhosis, impaired liver function and coagulopathy (including long-term use anticoagulant) History of deep vein thrombosis, ischemic heart disease or stroke | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Missed Pulmonary Embolism at the Emergency Department patients 18 years of age or older presented to the ED between January 2011 and March 2014 who received an ECG or any form of thoracic imaging patients below 18 years of age, as well as patients referred to the ED with suspected PE by departments within UHBS, other hospitals, or other healthcare providers | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 16.0-999.0, Pregnancy Suspected Deep Vein Thrombosis Compression Ultrasound D-dimer Unselected pregnant women (preciously documented positive beta hCG on urine or serum pregnancy tests) with Suspected acute symptomatic deep vein thrombosis Defined as new leg swelling or edema with onset in the last month or new leg pain (buttock, groin, thigh or calf) with onset in the last month Prior major VTE (proximal DVT or segmental or greater PE) Below the age of legal consent in jurisdiction of residence (18 years old for Quebec and 16 years old for rest of Canada) Unable or unwilling to provide informed consent Concomitant symptoms of suspected pulmonary embolism (chest pain or shortness of breath or syncope/pre-syncope or unexplained tachycardia) Need or plan for ongoing anticoagulant therapy (>2 weeks), at any dosage (i.e. prophylaxis or treatment dosage), throughout the ante-partum period Need for therapeutic anticoagulant therapy in the post-partum period (i.e. patients that are/will be treated for superficial phlebitis, mechanical valves, atrial fibrillation or other indications) | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 75.0-999.0, Acute Dyspnea Admission to the Emergency Department Age ≥ 75 years AND of acute dyspnoea Breathe rate ≥ 25 cycles/minute or PaO2 ≤ 70 mmHg or SpO2 ≤ 92% in room air or PacO2 ≥ 45 mmHg and pH ≤ 7.35 AND Electrocardiogram in sinus rhythm at admission | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 35.0-90.0, Chronic Obstructive Pulmonary Disease A clinical diagnosis of COPD Aged between 35 and 90 years Able to fluently read and speak English Willing and able to sign informed consent Be able to comply with the procedures outlined for the study Cardiac disease (including arrhythmias) A medicinal requirement for rate limiting calcium antagonists or beta blockers Cerebrovascular disease Peripheral vascular disease Requirement for supplemental oxygen therapy CO2 (carbon dioxide) retention Malignancy Orthopaedic or neurological conditions effecting the ability to exercise Clinically apparent heart failure Renal, hepatic or inflammatory disease | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 19.0-999.0, Venous Thromboembolism Adult (≥19 years of age) patients who are initiating treatment with Eliquis for the treatment of VTE or prevention of recurrent VTE for the first time in accordance with the Korean package insert will be enrolled in the study Patients with prior treatment with Eliquis before enrollment in this study Patients receiving Eliquis treatment for an indication not approved indication in Korea Patients meeting any of the following will not be included in the study i) Hypersensitivity to the active substance or to any of the excipients ii) Clinically significant active bleeding iii) Hepatic disease associated with coagulopathy and clinically relevant bleeding risk iv) Patients with increased bleeding risk due to such as following diseases Recent gastrointestinal ulceration history Recent intracranial or intracerebral haemorrhage history Intraspinal or intracerebral vascular abnormalities | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 21.0-85.0, Peripheral Arterial Disease Patients with peripheral arterial disease (PAD) Capable of giving informed consent Men and women age 21 years Diagnosed with PAD (i.e., ankle-brachial index below 0.9) Fontaine stage II or less no pain while resting Satisfactory history and physical exam Children Pregnant or nursing women Patients taking nitroglycerine or nitrate preparations Patients taking phosphodiesterase inhibitors such as sildenafil or tadalafil Patients taking proton pump inhibitors Ejection fraction < 40% Uncontrolled hypertension Uncontrolled diabetes Myocardial infarction within past 6 months or unstable angina Severe lung disease (i.e., on supplemental oxygen or frequently use rescue inhalers) | 0 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 0.0-999.0, Venous Thromboembolism Patients who start rivaroxaban for VTE （pulmonary embolism, deep vein thrombosis) anticoagulation therapy Patients who are contraindicated based on the product label and have already received Xarelto treatment | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Age ≥18 years Objectively confirmed diagnosis of acute PE by multidetector CT angiography, ventilation/perfusion lung scan, or selective invasive pulmonary angiography, according to established diagnostic with or without symptomatic deep vein thrombosis Absence of hemodynamic collapse, or decompensation, at presentation; Hemodynamic collapse or decompensation Intermediate-risk category of PE severity indicated by a positive (score ≥1) simplified pulmonary embolism severity index (sPESI), in combination with the presence of at least one of the following at presentation At least one sign of RV pressure overload/dysfunction on CT angiography or echocardiography Signs of myocardial injury as indicated by elevated troponin levels Signs of (RV) failure as indicated by NT-proBNP levels >600 pg/ml at baseline Ability of the subject to understand the character and individual consequences of the clinical trial; signed and dated informed consent of the subject available before the start of any specific trial procedures Pregnancy (a negative serum or urine pregnancy test should be available for women of child-bearing potential before study inclusion) or lactation Women of childbearing potential who do not practice a medically accepted highly effective contraception during the trial and one month beyond History of hypersensitivity to the investigational medicinal product or to any drug with similar chemical structure or to any excipient present in the pharmaceutical form of the investigational medicinal product Participation in another clinical trial during the present clinical trial or within the last three months Medical or psychological condition that would not permit completion of the trial or signing of informed consent Use of a fibrinolytic agent, surgical thrombectomy, interventional (catheter-directed) thrombus aspiration or lysis, or use of a cava filter to treat the index episode of PE Treatment with any therapeutically dosed anticoagulant for more than 48 hours prior to enrolment Need for long-term treatment with a low molecular weight heparin, vitamin K antagonists or NOAC, for an indication other than the index PE episode, or for antiplatelet agents except acetylsalicylic acid at a dosage ≤100 mg/day Active bleeding or known significant bleeding risk (e.g., gastrointestinal ulcer, malignant neoplasms, injuries or recent surgeries of the brain, spinal cord or eyes, recent intracranial bleedings, known or suspected esophagus varices, aneurysms or intraspinal or intracranial vascular abnormalities) Artificial heart valves requiring treatment with an anticoagulant | 2 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 18.0-999.0, Pulmonary Embolism Consecutive out patients with suspected PE in whom PE has been considered ruled out by negative D-dimers using an age-adjusted cut-off Life expectancy less than 3 months Geographic inaccessibility for follow-up Therapeutic anticoagulation for any indication Pregnancy Age less than 18 | 1 |
A 65 yo male with no significant history of cardiovascular disease presents to the emergency room with acute onset of shortness of breath, tachypnea, and left-sided chest pain that worsens with inspiration. Of note, he underwent a right total hip replacement two weeks prior to presentation and was unable to begin physical therapy and rehabilitation for several days following the surgery due to poor pain management. Relevant physical exam findings include a respiratory rate of 35 and right calf pain. | eligible ages (years): 0.0-999.0, Anterior Cruciate Ligament Reconstruction Patients undergoing scheduled anterior cruciate ligament (ACL) surgery at the Emory Orthopaedic and Spine Center Patients willing and able to provide written informed consent Parents willing and able to provide written informed consent for minors Patients who are pregnant or lactating Patients with liver dysfunction or renal failure Patients with a known allergy to ropivacaine Patients with a local infection Patients who take chronic pain medications Patients with an opioid tolerance Patients with known coagulopathy or bleeding risk Patients who are getting neuraxial anesthesia for surgery | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 6.0-16.0, Narcolepsy Inclusions written informed consent/assent is obtained meet minimal established by the International Classification of Sleep Disorders (ICSD) manual of the American Academy of Sleep Medicine (AASM) for narcolepsy (or presumed narcolepsy) or OSAHS OR have a previous diagnosis of narcolepsy or OSAHS before the screening visit have a complaint of ES are in good health as determined by a medical and psychiatric history, physical examination, ECG, and clinical laboratory tests have blood pressure values greater than those for the 5th percentile and less than the 95th percentile on the National High Blood Pressure Education Program guidelines for blood pressure levels for boys and girls ages 6 to 16 years girls who are postmenarchal or sexually active, have a negative urine pregnancy test at screening, must be using a medically acceptable method of birth control, and must agree to continue use of this method for the duration of the study (and for 2 cycles after participation in the study); acceptable methods of birth control barrier method with spermicide; steroidal contraceptives (oral, transdermal, implanted, or injected) in conjunction with a barrier method; intrauterine device (IUD); or abstinence able to swallow a tablet similar in size and shape to the study drug tablet negative urine drug screen (UDS) for any illicit drug, alcohol (ethanol), stimulants at screening; if positive for stimulants (prescribed for excessive sleepiness) at screening, UDS to be repeated after a washout period and before baseline have a parent or legal representative who is willing to participate in the study have self-induced sleep deprivation/poor sleep hygiene have a past or present seizure disorder (except history of single febrile seizure), a history of psychosis, or of clinically significant head trauma (eg, brain damage) or past neurosurgery have a history of suicide attempt, or are at suicidal risk a clinically significant drug sensitivity to stimulants such as amfetamine, dexamfetamine, or methylphenidate; and/or modafinil or any of its components use of any monoamine oxidase (MAO) inhibitors or selective serotonin reuptake inhibitors (SSRIs) within 2 weeks of the baseline visit (NOTE: SSRIs will be allowed for cataplexy if the patient has been on a stable dose for at least 1 month.) received any investigational drug (except modafinil) within 4 weeks of the baseline visit any disorder that could interfere with drug absorption, distribution, metabolism, or excretion (including previous gastrointestinal surgery) active, clinically significant gastrointestinal, cardiovascular, hepatic, renal, hematologic, neoplastic, endocrine, neurologic, immunodeficiency, pulmonary, or other major clinically significant disorder/disease any clinically significant deviation from the normal range(s) in the physical examination or ECG findings, or clinical laboratory test results (ie, serum chemistry, hematology) at the screening or baseline visit absolute neutrophil count (ANC) below the lower limit of normal at screening (NOTE: If the ANC is below the lower limit of normal at the baseline visit, the medical monitor will be consulted for continued in the study.) | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 14.0-999.0, Shoulder Dislocation Ages 14 years or greater Diagnosis of MDI or MDL-AII. Diagnosis will require two or more of the following Symptomatic translation (pain or discomfort) in one or more directions: anterior, inferior and/or posterior Ability to elicit unwanted glenohumeral translations that reliably produce symptoms with one of the following tests: the anterior and posterior apprehension tests, the anterior and posterior load and shift tests, the fulcrum test, the relocation test, the Fukuda test, and/or the push-pull or stress test with the patient supine Presence of a positive sulcus sign of 1 centimetre or greater gap that reproduces the patient's clinical symptoms of instability and should be both palpable and visible Symptoms of instability: subluxation or dislocation Written informed consent Failed at least 6 months of non-operative treatment Confirmed capsular-ligamentous redundancy as determined by diagnostic arthroscopy examination Neurologic disorder (ie: axillary nerve injury; syringomyelia) Cases involving third party compensation Patients with primary posterior instability A bony abnormality (Hill Sachs/bony Bankart) on standard series of x-rays consisting of a minimum of an anteroposterior view, lateral in the scapular plane and an axillary view Presence of a Bankart lesion on arthroscopic exam of the joint Presence of an unstable biceps anchor (ie: superior labral anterior and posterior [SLAP] lesion) on arthroscopic exam of the joint Presence of a full-thickness rotator cuff tear | 1 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 14.0-999.0, Joint Instability Shoulder Dislocation Clinical Age 14 years or greater Diagnosis of traumatic anterior shoulder instability, made by meeting all of the following Radiographic evidence or documented physician assisted reduction of anterior shoulder dislocation following a traumatic injury Ability to elicit unwanted glenohumeral translation which reproduce symptoms with one of the following tests: anterior apprehension, relocation test, or anterior load and shift test Radiological Closed growth plate on a standardized series of x-rays consisting of a minimum of an anteroposterior view, lateral in the scapular plane and an axillary view Clinical Diagnosis of multidirectional instability (MDI) or multidirectional laxity with anteroinferior instability (MDL-AII), made by two or more of Symptomatic (pain or discomfort) in inferior or posterior direction Ability to elicit unwanted posterior glenohumeral translation that reproduces symptoms with posterior apprehension tests, or posterior load and shift test Positive sulcus sign of 1cm or greater that reproduces patient's clinical symptoms Previous surgery on the affected shoulder other than diagnostic arthroscopy Cases involving litigation Significant tenderness of acromioclavicular/sternoclavicular joints on affected side Confirmed connective tissue disorder (ie: Ehlers-Danlos, Marfan) | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 14.0-999.0, Southern Tick-Associated Rash Illness Enrolled in protocol 02-I-0055 A person who is at least 14 years old Acute onset (within 14 days of visit to NIH) of an annular, erythematous, expanding erythema migrans (EM)-like rash that attains a size of at least 5 cm in diameter, when no alternative explanation for the rash can be found, and thought by the study physician to have a high likelihood to be due to STARI (due to exposure history, tick identification) History of tick bite at the rash site, or potential exposure to ticks in the southeastern and south central United States within 14 days prior to rash onset (including Maryland and Virginia) Consent to storage of biologic samples for later testing A person who, in the judgment of the investigator, would be at increased risk from the skin biopsy procedure and unlikely to be able to mount a serological response to the agent (for example, bone marrow transplant, B cell deficiency) FROM SKIN OF STUDY A person who meets the case definition but whose EM-like rash occurs on the face, neck, scalp, or over the tibia will not be enrolled for purposes of obtaining a skin biopsy specimen. Such a person may enroll for purposes of providing a clinical history and blood samples only. This also applies to patients with a history of forming large thick scars after skin injuries or surgery, or who have a history of excessive bleeding after cuts or procedures or are taking anticoagulants, or have severe skin disease. Also, patients who have received more than 24 hours of antibiotic treatment for the rash will be excluded from the biopsy. Patient with a history of allergy to lidocaine will also be excluded from the biopsy portion of the study | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 0.0-15.0, Fracture Forearm Midshaft Child Treatment both-bone forearm fracture age < 16 years dislocation stable fracture older than 1 week no informed consent refracture open fracture (Gustillo 2 and 3) | 1 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 0.0-15.0, Fracture Forearm Distal Child Treatment both-bone forearm fracture distal dislocated unstable after reposition age < 16 years fracture older than 1 week no informed consent refracture open fracture (Gustillo 2 and 3) both fractures of type torus | 1 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 15.0-18.0, Forearm Injuries Children that had had Ulna or Radius X-rays Signing Informed consent Unwillingness to sign informed consent | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 0.0-999.0, Degenerative Conditions of the Radial Head/Neck Post-traumatic Conditions of the Radial Head/Neck The will be the same as the indications stated in the FDA cleared (510(k) K040611) and (510(k) K051385) labeling for the device Replacement of the radial head for degenerative or post-traumatic disabilities presenting pain, crepitation, and decreased motion at the radio-humeral and/or proximal radio-ulnar joint with Joint destruction and/or subluxation visible on x-ray Resistance to conservative treatment Primary replacement after fracture of the radial head Symptomatic sequelae after radial head resection Revision following failed radial head arthroplasty The device is intended for single use with or without bone cement Modular Radial Head replacement prostheses have received FDA clearance for cemented and non-cemented application Patient selection factors to be considered 1) need to obtain pain relief and improve function, 2) ability and willingness of the patient to follow instructions, including control of weight and activity levels, 3) a good nutritional state of the patient, and 4) the patient must have reached full skeletal maturity The will be the same as the contraindications stated in the FDA cleared labeling (510(k) K040611) and (510(k) K051385) for the device. These contraindications Absolute contraindications Infection Sepsis Osteomyelitis Relative contraindications Uncooperative patient or patient with neurologic disorders who is incapable or unwilling to follow directions Osteoporosis Metabolic disorders which may impair bone function | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 19.0-999.0, Patellar Dislocation An acute primary traumatic patellar dislocation Previous dislocation or subluxation of the patella Pre-existing ipsilateral or contralateral knee pathology Previous knee trauma or patellar fracture | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-999.0, Heterotopic Ossification Subjects aged 18 years or greater Operative treatment of one of the following injuries An elbow dislocation with or without associated fractures An olecranon fracture-dislocation, but not simple olecranon fractures A distal humerus fracture An existing diagnosis of one of the following conditions Injury to the central nervous system, thorax, or abdomen precluding the immediate use of non-steroidal anti-inflammatory medications Fracture of any long bone since non-steroidal anti-inflammatory medications may increase the risk of nonunion History of gastritis, peptic ulcer disease, or upper gastrointestinal bleeding Impaired renal function (creatinine > 2.0), hypovolemia, heart failure, high blood pressure ( > 160/90), fluid retention, asthma, liver dysfunction (bilirubin > 2.0), or a coagulation disorder Allergy to non-steroidal anti-inflammatory medications Asthma, nasal polyps, urticaria, and hypotension associated with the use of NSAIDs Considerable dehydration Pregnant or breast-feeding women Concomitant use of one of the following drugs | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 14.0-30.0, Shoulder Dislocation to 30 years of age Willing to participate in follow-up for at least two years Acute, first-time, traumatic, isolated anterior dislocation of the shoulder Previous instability of the affected shoulder A history of significant ligamentous laxity or demonstrated multi-directional instability of the opposite shoulder Inability or unwillingness to comply with sling immobilization, rehabilitative protocol, or required follow-up assessments Incompetent or unwilling to consent A medical condition making the patient unable to wear a sling Significant associated fracture (Exception Hill Sachs of >20% or bony Bankart lesions>10%) Neurovascular compromise of the affected limb Concomitant ipsilateral upper extremity injuries which may affect the patient's ability to participate in, or benefit from, a rehabilitative program | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 50.0-85.0, Osteoarthritis Diagnosis of osteoarthritis Eligible for a unilateral or bilateral primary TKA to be performed by Dr. Michael Dayton (University of Colorado Hospital) Minimum of 110 degrees of active knee flexion No greater than 10 degrees of anatomic knee varus, 15 degrees anatomic valgus, and 10 degrees flexion contracture Body mass index less ≤ 40 kg/m2 Any brain, circulation, or heart problems that limit function Severe osteoarthritis or other orthopedic conditions that limit function in the lower extremity that is not undergoing the TKA | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 17.0-38.0, Shoulder Instability Surgical documentation of Pan Labral Lesion of shoulder Pre-operative documentation of outcomes scores lacking a Pan labral lesion other confounding pathology such as nerve deficit, chondral damage, rotator cuff tear | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 0.0-999.0, Rotator Cuff Tear Medium to large sized cuff tear (2-4 cm) Yes subscapular partial fraying or longitudinal split side to side Yes acromioplasty Yes AC arthritis with mumford procedure Yes biceps tenotomy or tenodesis No arthritic changes of glenohumeral joint No combined infection No mini-open procedures No complete subscapularis tear No incomplete repair No small tears or side to side repairs without anchors No pregnancy | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-999.0, Distal Radius Fracture Distal radius fracture treated with surgical management and wrist flexion contracture upon follow up Carpal Fractures (Scaphoid, Lunate, Hamate, and Trapezium) Radial nerve entrapment Arthrodesis Traumatic dislocation of the distal ulna | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 0.0-18.0, FEVER The estimates and the measurements will be carried out on children who are referred to an emergency unit and who are hospitalized in the pediatric department- both boys and girls of all ages. A patient might be measured several times | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-70.0, Distal Radius Fracture All patients admitted to Ahus and Lillestrom legevakt with a distal radius fracture are to be classified according to the system of the Orthopaedic Trauma Association (AO/OTA) All patients between the age of 18 and 70 diagnosed with a C2 or C3-type fracture, or a dislocated C1-fracture, are eligible for inclusion Gustillo-Anderson type III open fractures Previous distal radius/ulna-fracture and/or disabling hand injury of the same extremity Dementia Congenital anomaly Bilateral radius fracture Pathological fracture other than osteoporotic fracture Congenital bone disease (for example osteogenesis imperfecta) Age below 18 and above 70 Disabling nury to other parts og the movement apparatus at the same time as the current injury | 1 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-60.0, Acromio-clavicular Joint Dislocation (Type III) men or women ≥ 18 years-old AC joint dislocation type III with Zanca X-ray view demonstrating CC distance of 200% trauma-surgery delay of less than 14 days consent form signed AC joint dislocation type I, II, IV, V or VI associated neuro-vascular damage men or women > 60 years-old open dislocation local skin damage dislocation in a polytrauma patient floating shoulder fracture of the ipsilateral or controlateral arm or shoulder girdle fracture of the coracoid process of the scapula history of previous surgery to the shoulder | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-99.0, Lyme Disease Borrelia Burgdorferi for the diagnosis of Lyme disease can be found at The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America (4) Patients With EM (N=35), Post Treatment Age 18 or older EM diagnosed by the study physician or, with a diagnosis of EM that is thought to be highly likely by the study physician Treatment with at least 1 course of antibiotics that fulfills the Infectious Diseases Society of America guidelines for the recommended therapy for Lyme disease. There must be at least 1 month and up to 4 months between the end of the therapy and the study procedures High C6 Antibody Titer (N=35) Age 18 or older Diagnosed with confirmed or probable early or late Lyme disease as per Centers for Disease Control and Prevention (CDC) case definition (http://www.cdc.gov/ncphi/disss.nndss/caseded/lyme disease 2008.htm), have received recommended antibiotic therapy and have a high C6 ELISA titer (index above 3) at least 6 months after therapy Post Lyme disease syndrome (N=20) Age 18 or older History of allergy to surgical tape or Nitex nylon mesh History of severe reactions to tick bites (granuloma or systemic reactions) Inability to maintain the dressing for any reason Currently receiving any antibiotic or having received antibiotics in the last month (3 months for patients with post Lyme disease syndrome and high C6 titer) (except patients with EM on treatment) Pregnancy or lactation Unwillingness to use an effective method of birth control for 3 months after tick placement (women of child-bearing potential only) Not able to understand all of the requirements of the study or unable to give informed consent and/or comply with all aspects of the evaluation Investigational therapy during the time of the study and/or in the month prior to signing the informed consent Active severe skin disease, uncontrolled diabetes, cancer other than non-melanoma skin cancers, autoimmune disease requiring immunosuppressive therapy, or history of HIV, chronic viral hepatitis, or syphilis Oral steroids in the previous 2 weeks (nasal steroids and replacement doses of steroids are not exclusions) | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-999.0, Traumatic Knee Dislocation Ambulation without aids in pre-morbid condition Multi-ligament knee injury with or without associated peri-articular fracture Operative management within three weeks of the injury Poly-trauma with life-threatening injuries preventing rehabilitation Patients unable to comply with intensive rehabilitation Patients unable or unlikely to maintain follow-up | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 0.5-1.0, Influenza Boys or girls and aged >= 6 months old to <= 12 months old on the day of first vaccination Subject's parent(s) or legal guardian(s) must be willing to comply with planned study procedures and be available for all study visits Subject must be in good physical health on the basis of medical history, physical examination Subject's parent(s) or legal guardian(s) must read and signed the study-specific informed consent prior to initiation of any study procedure Subjects had received influenza vaccine History of hypersensitivity to eggs or egg protein or similar pharmacological effects to study medication Personal or family history of Guillain Barre' Syndrome An acute febrile illness within 1 week prior to vaccination Current upper respiratory illness (URI), including the common cold or nasal congestion within 72 hours Subjects with influenza-like illness as defined by the presence of fever (temperature >= 38'C) and at least two of the following four symptoms: headache, muscle/joint aches and pains (e.g. myalgia/arthralgia), sore throat and cough;Treatment with an investigational drug or device, or participation in a clinical study, within 3 months before consent Immunodeficiency, immunosuppressive or significant chronic illness not suitable for inactivated influenza vaccination History of wheezing or bronchodilator use within 3 months prior to study vaccine Receipt of live virus vaccine within 1 month prior to study vaccine or expected receipt vaccination before the last blood sampling for immunogenicity evaluation | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 8.0-35.0, Adolescent Developement Brain Developmental Biology Sample 1 Child volunteers will qualify for if they meet the following Good general health and normal IQ Age 8 years Body Mass Index (kg/m2) between the 15th and 85th percentiles for age and sex according to the US Centers for Disease Control and Prevention 2000 growth charts (103) A normal tempo of growth as determined by skeletal age within +/ 64 standard deviations of chronologic age according to the Greulich and Pyle radiographic atlas (102) (i.e., no evidence for precocious puberty or abnormal delay of maturation); Research for determining bone age will be performed by the collaborating pediatric endocrinologist. This criterion is required only for the initial entry into this study and is not one of the for subsequent visits No history of significant neurologic or cognitive disorders. Examples neonatal anoxic encephalopathy, seizure disorders, autism, and most learning disorders including attention deficit hyperactivity disorder Able to provide assent. Parents will provide consent Child volunteers will be excluded for the following reasons Presence of any medical condition that increases risk for MRI (e.g., pacemaker, metallic foreign body in eye or other body part, dental braces) Presence or history of medical conditions known to affect cerebral anatomy Children who are not pre-pubertal as indicated by the presence of Tanner stage 2 development (i.e., areolar development in girls and testicular volume > 3 cc in boys) Individuals who have, or whose parent or guardians have, current substance abuse or a psychiatric disorder or any other condition which, in the opinion of the investigators, would impede the ability to give informed consent or possibly hinder completion of the study; presence of any psychiatric disorder in the subject, sibling, or other first-degree relative Subjects who regularly use prescription medications (the use of over-the-counter medications will be reviewed on a case-by-case basis.) For females who have reached menarche: Pregnancy, lactation, or inability or unwillingness to undergo pregnancy testing (a urine pregnancy test will be performed prior to all MRI and X-ray procedures for girls who have had the onset of menses) Current or past use of psychiatric medication I.Q. < 70 Sample 2 | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 0.5-6.0, Nursemaid Elbow Pulled Elbow Pulled elbow suspected in any child presenting one of the following History of an adult or bigger person that had pulled the child's elbow non-intentionally Presence of intense pain at the arrival at the emergency department and unwilling to move the arm Any suspect of injury that could be intentional (child abuse) Any suspicion child of suffering a possible fracture (the mechanism of the injury was not from pulling the child's arm, the arm presents obvious deformity, ecchymoses, edema, etc.) The mechanism was from multiple trauma Any chronic disease affecting the adequate bone mineralization (vitamin D deficiency, osteogenesis, etc.) | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 8.0-12.0, Metabolic Syndrome X Pupils in 3rd and 4th grades Primary Schools in the Zealand Region and Capital Region of Denmark Schools with an available school kitchen, that can be approved by the food authorities Schools where at least 60 % of the pupils in three or more classes signs up to participate in the Study The children should not participate in a scientific study or have participated in a scientific study within the last 4 weeks. This, however depends on the character of the other study The children must not suffer from serious food allergies or food intolerance The children must not suffer from diseases or conditions that makes them ill-suited for participation in the study, eg. malabsorptive conditions or serious mental disorders The schools must not offer an well-established common meal plan, that provides most of the pupils with healthy food on a daily basis | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-80.0, Distal Radius Fracture Wrist Contracture Distal radius fracture treated with surgical management and wrist flexion contracture upon follow up Carpal Fractures (Scaphoid, Lunate, Hamate, and Trapezium) Radial nerve entrapment Arthrodesis Traumatic dislocation of the distal ulna | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-85.0, Elbow Trauma Requiring Operative Management Terrible Triad Radial head fracture surgical treatment Monteggia and Trans-olecranon Fracture Dislocations Distal Biceps Tendon Injuries Distal Humerus Fractures Coronoid Fractures Capitellar-Trochlear fractures Olecranon Fractures Associated Traumatic Brain Injury Burn Injuries associated with elbow trauma History of Gastric Ulcers Documented allergies to any Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Severe Asthma Previous operative fixation to affected elbow Participation in other research study Inability to speak / understand English | 1 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 1.0-17.0, Fracture Treatment Children age 1-17 with buckle fractures of the distal radius and/or ulna. - Patients are excluded if there is any other injury to the upper limb or serious bodily trauma that might complicate pain scores. Children with suspected or proven metabolic bone disease, or pathologic fractures are excluded due to resultant abnormal bone healing | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 4.0-18.0, Cerebral Palsy Patient Undergoing Hip Surgery Quality of Life Ages 4-18 Undergoing surgical treatment for hip subluxation or dislocation Diagnosis of cerebral palsy or similar condition causing motor impairment Consent to participate Diagnosis of neuromuscular disorders other than cerebral palsy younger than 4, older than 18 Reimer's migration percentage <40% | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 9.0-14.0, Female Puberty Female volunteers in early to mid-puberty (i.e. late Tanner 1 [estradiol level >20 pg/ml], Tanner 2, or Tanner 3) Premenarcheal BMI-for-age > 85th percentile or < 5th percentile Pregnancy Inability to comprehend what will be done during the study or why it will done Hyperandrogenism (e.g., hirsutism, elevated free testosterone level) History of allergy to progesterone (which is extremely rare) Hemoglobin less than 12 g/dl and hematocrit less than 36% Persistently abnormal sodium, potassium, or bicarbonate (i.e. confirmed on repeat) Persistently elevated creatinine, hepatic transaminases, or alkaline phosphatase (i.e., confirmed on repeat) Total bilirubin > 1.5 times upper limit of normal (i.e. confirmed on repeat) Significant history of cardiac or pulmonary dysfunction (e.g., known or suspected congestive heart failure; asthma requiring intermittent systemic corticosteroids; etc.) | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 0.25-15.0, Sinusitis, Acute Child with ABRS with inflammation as bacterial infection who has the following symptoms/signs on the day of or the day before the first dose of the investigational product: Redness of the nasal mucosa; nasal or postnasal discharge is purulent or mucopurulent; Pathological shadow in the paranasal sinus on a radiogram (only for reference). Patient with surgical history should be excluded but patient with a pervious surgery more than 365 days before and apparently preserved maxillary sinus mucosa or patient with a previous surgery of nasal polypectomy more than 90 days before may be enrolled in the study Child with ABRS whose severity is classified as moderate or severe (total score >=4) based on the nasal cavity findings and symptoms Boy or girl aged >=3 months to <15 years Body weight >=6 kilograms (kg) to <40 kg Written informed consent has been obtained from the child's legally acceptable representative. If the child is 12 years or older, the child him/herself should have also provided written informed consent. The investigator (or sub-investigator) should attempt to obtain written informed consent from the child him/herself as far as possible even if the child is less than 12 years of age Severe infection that requires surgical treatment (e.g., child with systemic symptoms such as fever associated with swelling face, child with almost full nasal obstruction due to a large nasal polyp) Serious complication such as acute mastoiditis, facial palsy, bacterial meningitis, and brain tumor Congenital disorder such as maxillofacial dysplasia Need of concomitant use of other antibiotics Serious underlying disease (e.g., cardiac disease, malignancy, juvenile diabetes) Concurrent infection associated with gastrointestinal symptoms (e.g., diarrhoea, vomiting) that may affect safety assessment Known hypersensitivity to any component of CVA/AMPC or penicillin or cephem antibiotic, or past history of a serious adverse reaction possibly related to any of these agents Infectious mononucleosis Current hepatic impairment, or past history of jaundice or hepatic impairment due to any component of CVA/AMPC Past or current renal impairment (e.g., serum creatinine >=1.5 × Upper Limit of Normal, creatinine clearance of less than 30 milliliter/liter [mL/L]) | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 50.0-999.0, Osteoarthritis, Hip Age greater than 50 years Undergoing primary total hip arthroplasty at Holland Orthopaedic and Arthritic Centre Any previous surgery about the ipsilateral hip Patients being considered for simultaneous bilateral total hip arthroplasty Patients with a neuromuscular disorder or recognized hypermobility syndrome Patients without sufficient language skills to communicate in spoken and written English | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-45.0, Lateral Epicondylitis Individuals who meet all of the following are eligible for enrollment into the study Adult between 18-45 years of age Pain over the lateral humeral epicondyle provoked by at least two of the following: gripping, palpation, stretching of forearm extensor muscles and resisted wrist or middle finger extension Persistent pain for at least 3 months despite conservative treatments including medication (oral nonsteroidal antiinflammatory drugs (NSAIDs) and analgesics), brace application, or physiotherapy Patients with structural tendon changes at the origin of the extensors, demonstrated during musculoskeletal ultrasound Individuals who meet any of the following are disqualified from enrollment of the study Patients with a history of advanced cervical arthrosis in the C4-C6 segments Bilateral LE with central sensitization Symptoms compatible with posterior interosseous nerve entrapment Previous surgery, fractures, trauma or previous history of rheumatic disorders in the area of the lateral epicondyle History of corticosteroid injection at the lateral epicondyle within the last 3 months Two experienced professionals performed recruitment and examination of subjects in order to assess for criteria. All eligible patients provided written informed consent | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 70.0-999.0, Distal Radius Fracture Dorsally displaced, 20 degrees or from a plane perpendicular do the diaphyseal axis, fracture Low energy injury Patient 70 years old or older hours or less since injury at time of diagnosis Patient registered in the Stockholm region Patient understands spoken and written swedish Intraarticular displacement in radiocarpal joint of more than 1 mm Ulna fractured proximal to the base of the styloid process of ulna Earlier unilateral functional impairment of hand/wrist Injury to tendon, nerve or skin besides the fracture Rheumatoid arthritis or other severe systemic joint disease Severe psychiatric disorder, ongoing drug abuse or dementia (Pfeiffer score 5 points or less) Besides the wrist fracture also other big injuries, for example fracture of hip, shoulder or ankle Medical illness that makes general anesthesia impossible | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-65.0, Arthritis Female Sexually active Heterosexual years undergoing THR (prospective) or having undergone THR surgery within the last year Sexually inactive pre-operatively and wishing to remain sexually inactive post-operatively Unable to comprehend English and with capacity to consent and follow instruction Unable to sign and date the ethics committee approved consent documentation | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-65.0, Spinal Cord Injuries Shoulder Impingement Syndrome Above 18 years old Have paraplegia as a result of a spinal cord injury morn than one year Able to perform push-ups independently and raise the arm above the head Self-propel a manual wheelchair as the primary means of mobility Have history of fractures or dislocations in the shoulder, elbow, or wrist from which you have not fully recovered Have upper limb pain as a result of a complex regional pain syndrome Have a implant or pacemaker within the torso or upper arm Pregnant female | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 18.0-70.0, Basilar Invagination Associated With Atlantoaxial Dislocation Age between 18-70 Patients with cervical CT display that atlanto occipital fusion or partial fusion, Atlantoodontoid interval(ADI)>>3mm, odontoid tip over Qian line(CL)>>3mm Agreed to the surgical operation treatment The patient can carry out clinical follow-up and agree to long-term clinical follow-up Signed informed consent Patients with traumatic atlanto-axial dislocation Patients with rheumatoid atlantoaxial dislocation Patients with a history of occipital cervical junction operation Patients with severe cerebellar tonsillar hernia (reach the C2 margin), needed to remove tonsil of cerebellum Patients during pregnancy and the postpartum period within 3 months The life expectancy of < 1 years Severe dementia(MMSE<18) Severe renal failure (CR > 2.5mg/dl) Serious cardiovascular disease (such as unstable angina, heart failure) Atrial fibrillation and other severe arrhythmia | 0 |
A 47 year old male who fell on his outstretched left arm presents with pain and bruising on the inside and outside of the elbow, swelling, and inability to bend the arm. On the x-ray, the ulna has dislocated posteriorly from the trochlea of the humerus. The radius has dislocated from the capitulum of the humerus. | eligible ages (years): 13.0-18.0, Contraception Ages 13 to 18 years old Speaks English or Spanish Has menstrual periods Has Medicaid insurance Seeking contraception as their primary complaint Currently pregnant based on urine or serum pregnancy testing Has an IUD or contraceptive implant (Implanon/Nexplanon) Critically ill, hemodynamically unstable, altered mental status, developmentally delayed, severe pain or distress, or have major trauma In juvenile justice custody | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Atherosclerosis Cardiovascular Diseases Hypertension, Renovascular Renal Artery Obstruction Either Documented history of hypertension on two or more anti-hypertensive medications OR Renal dysfunction, defined as Stage 3 or greater chronic kidney disease (CKD) based on the new National Kidney Foundation (NKF) classifications (estimated glomerular filtration rate [GFR] less than 60 mL per minute per 1.73 m^2, calculated by the modified Modification of Diet in Renal Disease [MDRD] formula) One or more severe renal artery stenoses by any of the following pathways a. Angiographic: greater than or equal to 60% and less than 100% by renal angiogram OR b. Duplex: systolic velocity of greater than 300 cm/sec OR c. Core Lab approved Magnetic Resonance Angiogram (MRA) (refer to the protocol for specific criteria) demonstrating stenosis greater than 80% OR stenosis greater than 70% with spin dephasing on 3D phase contrast MRA OR stenosis greater than 70% and two of the following: i. Ischemic kidney is greater than 1 cm. smaller than contralateral kidney ii. Ischemic kidney enhances less on arterial phase iii. Ischemic kidney has delayed Gd excretion iv. Ischemic kidney hyper-concentrates the urine v. 2-D phase contrast flow waveform shows delayed systolic peak vi. Post-stenotic dilatation d. Clinical index of suspicion combined with a Core Lab approved Computed Tomography Angiography (CTA) demonstrating Stenosis is greater than 80% by visual assessment on high quality CTA Stenosis is greater than 70% on CTA by visual assessment and there are two of the following i. The length of the ischemic kidney is greater than 1 cm. smaller than contralateral kidney ii. Reduced cortical thickness of ischemic kidney iii. Less cortical enhancement of ischemic kidney on arterial phase iv. Post-stenotic dilatation Unable to provide informed consent Unable or willing to comply with study protocol or procedures Must be greater than 18 years of age Fibromuscular dysplasia or other non-atherosclerotic renal artery stenosis known to be present prior to randomization Pregnancy or unknown pregnancy status in female of childbearing potential Participation in any drug or device trial during the study period, unless approved by the Steering Committee Prior enrollment in the CORAL study History of stroke within 6 months, if associated with a residual neurologic deficit* Any major surgery, major trauma, revascularization procedure, unstable angina, or myocardial infarction 30 days prior to study entry* Any planned major surgery or revascularization procedure, outside of the randomly allocated renal stenting indicated by the protocol, after randomization* | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 10.0-16.0, Heterozygous Familial Hypercholesterolemia Mixed Dyslipidemia 16 years old Heterozygous familial hypercholesterolemia Homozygous familial hypercholesterolemia Pregnant or lactating females Major surgery during the six month prior study Other protocol defined and | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 40.0-80.0, COPD Criteria:Participants with COPD with an FEV1 of 80−30% predicted. This will incorporate the majority of participants with COPD seen within the chest clinic. Patients with an FEV1 > 80% predicted are not generally severe enough to warrant hospital follow up. These patients are also unlikely to have severe enough disease (and therefore airway inflammation) which may be modified by the therapeutic agents we are studying Patients with an FEV1 < 30% tend to have more severe symptom limitation and generally (though not always) find participation in a clinical trial involving 4 visits to the clinic difficult. Their airway disease is also generally less responsive to therapeutic intervention and as a consequence finding measurements which show changes to these therapeutic interventions is more difficult COPD patients All participants will be classified to Stage 2−3 of the GOLD (Global initiative for Obstructive Lung Disease) guidelines Male or female, aged 45-80 years (according to GOLD guidelines) < FEV1 < 80% predicted FEV1/FVC < 70% Cigarette exposure of >10 pack−years# With or without chronic symptoms (cough, sputum production, dyspnea) Steroid therapy will be stopped before run−in, but long acting bronchodilators are acceptable Any history or evidence of asthma Pregnancy, breast−feeding or planned pregnancy during the study. Fertile women not using acceptable contraceptive measures, as judged by the investigator Hospital admission with respiratory infection within the last 6 months Upper respiratory infection within the last 4 weeks Participants who have received research medication within the previous one month Participants unable to give informed consent Any mental condition rendering the participant unable to understand the nature, scope and possible consequences of the study Known or suspected hypersensitivity to study therapy or excipients Participants with significant or unstable ischemic heart disease, arrhythmia, cardiomyopathy, heart failure, uncontrolled hypertension as defined by the investigator, or any other relevant cardiovascular disorder as judged by the investigator Any current respiratory tract disorders other than COPD, which is considered by the investigator to be clinically significant | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 65.0-999.0, Atrophy community living elderly females >/=65 years live expectation > 2 years secondary osteoporosis CVD-events including stroke participation in other studies medication and illness affecting bone metabolism within the last 2 years medication with impact on falls low physical performance (<50 Watt during ergometry) excessive alcohol-intake | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-80.0, Coronary Artery Disease Acute Myocardial Infarction Age 18 to 80 Anterior myocardial infarction with Pathological Q-waves in at least 3 contiguous anterior precordial leads, assumed to be new CK peak>5 times the upper limit of normal with positive MB bands Ejection fraction <=40% or anterior dyskinesis or documented LV Thrombus MI onset < 7 days from randomization Inability to give written informed consent Medical conditions that would prohibit discharge within 48 hours with the exception of need for anticoagulation Cardiogenic shock, rest angina unresponsive to medical therapy or serious ventricular arrhythmia in the 24 hours prior to randomization Patients scheduled for surgical procedure in the next 4 months that would prevent use of enoxaparin or warfarin Anemia: Baseline Hgb<=9 gm for women, <=10 gm for men or platelet count<100,000 Renal insufficiency (creatinine >2.0 mg/dl) Serious liver disease as reflected by INR>1.3 Stroke within past 6 months or a prior documented intracranial or subarachnoid hemorrhage Active bleeding or major surgery within 2 weeks prohibiting the use of anticoagulants Acute pericarditis | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 30.0-80.0, Acute Myocardial Infarction Patients will be eligible if presenting all characteristics described below ST segment elevation myocardial infarction, according to the WHO definition (two from the following three) i) Presence of chest pain. ii) Presence of ST segment elevation in two or more contiguous leads. iii) Elevation of the myonecrosis markers Age between 30 and 80 years old Invasive ventriculography presenting ejection fraction <50% (Dodge method) and segmentary dysfunction of the infarction area, measured immediately before PCI. Among patients submitted to thrombolytic therapy, the angioplasty of the related artery should be preferably done up to 24h after thrombolysis, with a maximum deadline of 48h after thrombolysis. This recommendation is based on the last Percutaneous Coronary Intervention guideline published by the European Society of Cardiology, in April 2005.68 IA recommendation degree Patients will be ineligible if presenting any of the characteristics described below AMI related artery presenting TIMI < 3 at the moment f cell injection Left Main Coronary Artery Lesion of >50% or multivessel coronariopathy (>70% lesion in vessels with >2,0mm diameter in left anterior descending, circumflex and right coronary territory) indicating the need for CABG or angioplasty with three or more stents implant Coronary anatomy, after thrombolytic reperfusion, presenting no need for angioplasty with stent implant Final Diastolic Pression of the LV higher than 30 mmHg during ventriculography for evaluating EF for the research protocol (item "c" of criteria) Cardiac arrest or Killip IV AMI at admission with need of ventilatory support Cardiogenic shock persisting up to the third day after AMI (with need of Intra-aortic balloon pump or vasopressors) AMI mechanical complications (ventricular septal defect, papillary muscle rupture, and left ventricular free wall rupture) Significant valve disease, defined as aortic stenosis (mean systolic pressure gradient across the aortic valve >50mmHg), mitral stenosis with a valvar area less than 1,5 cm,2 moderate to severe aortic and/or mitral regurgitation Chronic use of immunosuppressive agents | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 30.0-999.0, Hypertension Atherosclerosis Every patient referred fo abdominal CT aged 30-100 Contraindication for IV contrast injection failure to demonstrate renal arteries with contrast refusal to sign an informed consent | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Neuralgia Spinal Cord Injuries Subjects with nerve pain after Spinal cord injury (traumatic, diving, ischemic and after removal of benign tumors (except meningioma and fibromas) Pain has to be chronic(continuous for at least 3 months or intermittent for at least 6 months Pain score at least 4 in 4 of 7 days prior to receive treatment Pregabalin use in the last 60 days, prior intolerance to pregabalin Creatinine clearance <60 mL/min White blood cell count <2500/mm3; neutrophil count <1500/mm3; platelet count <100 x 103/ mm3 Abuse of drugs or alcohol Unstable medial conditions Clinically significant abnormal electrocardiogram (ECG) Presence of severe pain associated with conditions other than spinal cord injury that could confound the assessment or self-evaluation of pain due to spinal cord injury | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-75.0, Acute Anterior Myocardial Infarction Each eligible patient must meet the following Have ECG evidence of ongoing acute anterior myocardial infarction, involving a large area of myocardium, as defined by the following ECG a. Anterior infarct: ST-segment elevation >0.2mV measured 0.08 sec after the J point in 2 or more anatomically contiguous precordial leads, V1 through V4; and/or >0.2mV in lead V5 V6 Present to the RAPID MI-ICE site within six (6) hours of the onset of acute cardiac ischemic signs or symptoms (such as chest pain or pressure, arm or jaw pain, dyspnea, nausea/vomiting, or syncope) Be a candidate for PCI and have PCI planned as the immediate intervention Be willing and able to comply with study procedures, including returning for the MRI scan at 4 ±2 days and return for the clinical examination on Day 30 Provide written informed consent prior to the initiation of study-specific procedures Be in Killips Class I Patients are not eligible for the study if they meet one or more of the following Age less than eighteen (<18) years of age Age greater than seventy-five (>75) years of age Are pregnant Have a suspected aortic dissection History of a prior anterior myocardial infarct or prior large myocardial infarct The suspected etiology of myocardial infarction is primarily related to substance abuse (e.g., cocaine, methamphetamine, etc.) Acute administration of a thrombolytic agent for the qualifying MI If (during the screening process) the determination is made by site-study personnel that initiation of cooling prior to diagnostic coronary angiography is technically not feasible for any reason (should the patient be randomized to the Hypothermia Arm), the prospective subject should not be enrolled Require an immediate surgical or procedural intervention other than PCI (e.g. CABG) | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Myocardial Infarction Successful primary PCI (TIMI 2/3) for a first acute myocardial infarction, diagnosed by chest pain suggestive for acute myocardial infarction symptom onset < 12 hour before hospital admission, or < 24 hour in case ongoing ischemia ECG with ST-T segment elevation > 1 mV in 2 or more leads TIMI flow 0/1 before primary PCI on diagnostic coronary angiography Hemoglobin levels > 10.6 mmol/L Anticipated additional revascularisation within 4 months Cardiogenic shock Presence of other serious medical conditions Pregnancy/breast feeding Malignant hypertension End stage renal failure (creatinin > 220 micromol/l) Previous treatment with rh-EPO Blood transfusion <12 weeks prior to randomisation Polycythemia vera | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 65.0-999.0, Dementia 65 years of age or older Diagnosed with dementia by a physician Mini-Mental State Examination score of 23 points or less Capable of participating at least once a week for 6 weeks in succession Management of a medical risk required Impaired ability to pedal the ergometer because of an orthopedic or surgical disease of the lower extremities or central nerve paralysis Never having been on a bicycle, and incapable of pedaling well | 1 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 55.0-999.0, Bone Loss Osteoporosis Breast Cancer elderly postmenopausal women (ages 55 and older) osteopenic (DXA T-score -1.0 to -2.5 SD). However, after full counseling about the risks, benefits, and options regarding therapy for osteoporosis and discussion with her PCP, an osteoporotic woman may enroll in the study with breast cancer on aromatase inhibitor therapy with no evidence of distant metastatic disease or osteoporosis (by BMD or clinical history) type of surgical procedure or addition of radiation therapy prior to this aromatase inhibitor therapy will not patients Participants must provide voluntary, written informed consent to participate in the study, which includes understanding of the procedures, medications, and risks and benefits Women with stage 4 breast cancer (presence of distant metastases) Women with normal bone density by DXA (T-score > -1.0 SD)bone density by DXA, except in the instance of a fragility fracture Women with history of any illness known to affect bone and mineral metabolism, such as renal failure (estimated GFR <30), hepatic failure, malignancy (excluding breast cancer, treated superficial basal and squamous cell carcinoma and malignancies where the diagnosis itself or its treatment would not adversely affect bone metabolism), untreated primary hyperparathyroidism, and malabsorption Women being treated with oral glucocorticoid therapy >3 months for suppression therapy, and certain anti-seizure medications which may adversely affect bone metabolism (phenobarbital, phenytoin, carbamazepine) Those with untreated active peptic ulcer disease Those with osteoporosis by BMD (T-score -2.5 SD at the spine or total hip) or a history of fragility fracture as an adult. However, as discussed above, osteoporotic women may elect to enroll in the study Women treated with oral bisphosphonates or calcitonin for 3 months within the last year (3 month washout period) Men and children will be excluded because they do not get postmenopausal osteoporosis following treatment with an aromatase inhibitor Women with very poor dental hygiene (as assessed by the baseline dental exam) in need of dental extraction during the study Use of fluoride for more than 1 month ever (except for dental treatment) | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 21.0-999.0, Contrast Induced Nephropathy Age > 21 year Glomerular Filtration Rate (GFR) 15-60ml/min calculated by MDRD formula Scheduled to undergo elective PCI Able to receive 12 hours of pre-hydration Written informed consent GFR less than 15ml/min or patients diagnosed with end stage renal failure Increase in serum creatinine levels of > 0.5mg/dl or 44umol/l in the previous 24 hours Preexisting dialysis Pulmonary edema or moderate to severe congestive heart failure (New York Heart Association [NYHA] III-IV) Patient unable to withstand the fluid load and hemodynamics compromise Uncontrolled hypertension (untreated systolic blood pressure > 160 mmHg, or diastolic blood pressure > 100mmHg.) Emergency cardiac catheterization (i.e. patient presenting with ST segment elevation myocardial infarction undergoing primary angioplasty) Recent exposure to radiographic contrast (within two days of the study) Allergic to radio-contrast | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-75.0, Cardiovascular Disease Signed informed consent to 75 years of age, inclusive Male or female Negative pregnancy test for women of child-bearing potential, or surgically sterile, or post menopausal Acute MI defined as Typical rise and gradual fall (troponin) or more rapid rise and fall (CK-MB) of biochemical markers of myocardial necrosis with at least one of the following Ischemic symptoms Development of pathologic Qwaves on the ECG ECG changes indicative of ischemia (ST segment elevation or depression) First anterior or inferolateral STEMI or Qwave MI (QMI Anterior: V1-V3 or V1-V4 or V1-V5 or V1-V6.QMI Inferior: L2, L3, AVF, or L2, L3, AVF+ V5, V6 or L2, L3, AVF+ V6-V9 [posterior leads]) History of CHF, Class I to Class IV, as per NYHA History of prior LV dysfunction At time of application of study device Killip III-IV (pulmonary edema, cardiogenic shock hypotension systolic < 90 mmHg and evidence of peripheral hypoperfusion oliguria, cyanosis, sweating) or HR > 100 bpm Prior CABG Prior MI History of stroke Significant valvular disease (moderate or severe) Patient is a candidate for CABG or PCI on non-IRA | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 19.0-999.0, Acute Renal Failure Male or female > or equal to 19 yrs of age ARF defined by at least one of the following Volume overload from inadequate urine output despite diuretic agents Oliguria (urine output < 200 ml/12hrs) despite fluid resuscitation and diuretic administration Anuria (urine output < 50 ml/12 hrs) Acute azotemia (BUN > or equal to 80 mg/dl) Acute hyperkalemia not responsive to medication (K+ > or equal to 6.5mmol/L) An increase in serum creatinine of > 2.5 mg/dl from normal values or a sustained rise in serum creatinine of > or equal to 1 mg/dl over baseline Patients with end stage renal disease Patients who have had more than one previous dialysis session for acute or chronic renal failure during the current hospitalization Patient weight greater than 125 kg Patient weight less than 50 kg Pregnancy Prisoner Non-candidacy for continuous renal replacement therapy (CRRT) Patient/surrogate refusal | 1 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Cardiovascular Disease Men and women admitted for an IHD event (acute coronary syndrome or revascularization procedure) who are at low or moderate risk.91 Regular Internet access (home, work or other environment) Over 18 years of age Permission of the attending physician Able to read, write and understand English without difficulty No physical limitations to regular activity Previous experience with a cardiac rehabilitation program Patients with depression, uncontrolled diabetes and other significant co-morbidities that may interfere with effective IHD management Those patients, who in the mind of the attending physician, are unsuitable for participation Those unable to provide informed consent Pregnant women High-risk patients for safety considerations (future studies will high-risk patients) | 2 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Ischemic Stroke Myocardial Ischemia Coronary Arteriosclerosis Age ≥ 18 years old Symptoms suggestive of an acute ischemic stroke Informed consent Present intracerebral or subarachnoid haemorrhage Present intracerebral vascular malformation Present transient ischemic attack Prior coronary bypass surgery or percutaneous coronary intervention Pacemaker Allergy to contrast Lack of cooperation | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Primary Hypercholesterolemia Homozygous Familial Hypercholesterolemia Outpatient men or women, age 18 years and above Patients with primary (heterozygous familial and non-familial) hypercholesterolemia or homozygous familial hypercholesterolemia Known hypersensitivity to Ezetimibe Moderate to severe hepatic insufficiency Persistent elevation of serum transaminase levels of more than 1.5 times the upper limit of normal Pregnancy or lactation Concomitant intake of bile acid sequestrants (resins), nicotinic acid (niacin), fibric acid (fibrates), or cyclosporine | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Renal Artery Stenosis PAD and unilateral ostial >60% RAS and hypertension Conditions which imply RAS stenting (bilateral significant renal disease, single functioning kidney, or patients whose conditions cannot be managed medically or by intervention) Allergy to contrast agents or medication administered for best medical treatment (in particular ASA and statins) | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 30.0-80.0, Myocardial Infarction First anterior myocardial infarction Low systolic ventricular function Bleeding tendency Contraindication to G-CSF Cardiogenic shock Hemodynamic instability Hepatic or renal disease Multivessel disease | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Hyperplasia Restenosis Patients must meet all of the following The patient must be > 18 years of age Diagnosis of stable angina pectoris as defined by Canadian Cardiovascular Society Classification (CCS I, II, III, IV) or ACS (except STEMI) Treatment of de novo lesion in a major coronary artery in patients with single or two-vessel disease Target vessel diameter at the lesion site is >2.50mm and <3.50mm in diameter (QCA) Target lesion is >10mm and <24mm in length (visual estimate) Target lesion stenosis is >50% and <100% (visual estimate) Acceptable candidate for coronary artery bypass surgery (CABG) Patient is willing to comply with the specified follow-up evaluation Patient must provide written informed consent prior to the procedure using a form that is approved by the local Ethics Committee Patients will be excluded if any of the following conditions apply multiple lesions in the same vessel ACS with STEMI (within 48 hours) vessel size < 2.50mm and >3.50mm reference diameter length of the lesion > 24 mm unprotected left main coronary disease with >50% stenosis have an ostial target lesion have a target lesion in a venous graft angiographic evidence of thrombus within target lesion calcified lesion which cannot be successfully predilated | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 50.0-999.0, Cataract Subjects must have a clinically documented diagnosis of age-related cataract Subjects must have clear intraocular media other than cataract Subjects must be undergoing primary in-the-bag intraocular lens implantation for the correction of aphakia following continuous curvilinear anterior capsulotomy and phacoemulsification cataract extraction Subjects with any anterior segment pathology for which extracapsular phacoemulsification cataract surgery would be contraindicated Subjects with diagnosis of degenerative visual disorder Subjects who have any inflammation or edema (swelling) of the cornea Subjects with immunodeficiency disorders Subjects who have had previous intraocular surgery in the study eye Subjects with incomplete/damaged zonule, or with conditions associated with increased risk of zonular rupture Subjects with chronic use of systemic steroids or immunosuppressive medications | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-65.0, Obesity, Morbid Ischemic Heart Disease Morbidly obese patients who fulfill the NIH for surgical intervention Patients deemed unfit for surgery Pregnant women, or who are attempting conception Subjects with any history of myocardial infarction, coronary artery bypass grafting surgery, coronary angiography with angioplasty and/or stenting, or any lesion > 50% of the coronary artery luminal diameter, cerebrovascular accident, or peripheral vascular disease with abnormal electrocardiograms and/or echocardiography History of drug or alcohol abuse Chronic liver disease | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Hyponatremia Acute Decompensated Heart Failure Presents to emergency department with documented history of CHF and symptomatic ADHF, will be treated for ADHF, and primary reason for admission to the hospital is ADHF Dyspnea at rest or with minimal exertion and must have moderate shortness of breath (SOB) in any of the first three Provocative Dyspnea Assessment positions Severe pulmonary congestion as evidenced by jugular venous distention or lower extremity/sacral edema or rales upon chest auscultation or chest x-ray BNP > 400 or NT-pro BNP > 1500 drawn during Screening Systolic blood pressure >= 100 mmHg to < 180 mmHg at time of start of study drug Serum sodium value >= 115 mEq/L (115 mmol/L) and < 135 mEq/L (135 mmol/L) during Screening Clinical evidence of volume depletion Active ongoing acute coronary syndrome or acute ST segment elevation myocardial infarction (or has experienced a myocardial infarction within 30 days of Screening) In cardiogenic shock Calculated creatinine clearance < 30 mL/min/1.73 m2 as estimated by the Modification of Diet in Renal Disease (MDRD) equation, has received intravenous (IV) contrast agent within 72 hours prior to randomization or is expected to receive IV contrast agent within the first 72 hours of study participation Ultrafiltration within the past 72 hours Currently using or expected to use inotropic therapy Cardiac bypass grafts in the past 60 days Cerebrovascular accident in the past 30 days Uncontrolled brady or ventricular tachyarrhythmias requiring emergent pacemaker placement or treatment | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Acute Coronary Syndrome typical chest pain ST segment elevation or depression in ECG indication for coronary angiography; if necessary with PCI and 4) signed inform consent known past history of a myocardial infarction not signed informed consent | 2 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Hypercholesterolemia Outpatient men or women, age 18 years and above Patients with primary (heterozygous familial and non-familial) hypercholesterolemia Known hypersensitivity to Ezetimibe and Simvastatin Moderate to severe hepatic insufficiency Persistent elevation of serum transaminase levels of more than 1.5 times the upper limit of normal Pregnancy or lactation Concomitant intake of bile acid sequestrants (resins), nicotinic acid (niacin), fibric acid (fibrates), or cyclosporine | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-80.0, Ventricular Tachycardia Coronary Artery Disease Left Ventricular Dysfunction Coronary artery disease For the purpose of this study, coronary artery disease will be defined as the presence of a 50 % or more diameter stenosis of the left main coronary artery, or 75 % or more diameter stenosis of the left anterior descending, circumflex or right coronary arteries, or the history of a surgical or percutaneous revascularization procedure, or history of successful thrombolysis, or a history of prior myocardial infarction (e.g.: documented by Q-wave, R-reduction, aneurysm) Left ventricular ejection fraction ≤ 50 % as estimated by echocardiography or contrast ventriculography within the previous 30 days and evidence for old myocardial infarction (ECG, echocardiographic or venticulographic) One episode of documented stable clinical VT without any reversible causes Written informed consent Age < 18 years or > 80 year Protruding LV thrombus on pre-ablation echocardiogram Acute myocardial infarction within the preceding 1 months Class IV NYHA heart failure Valvular heart disease or mechanical heart valve precluding access to the left ventricle Unstable angina Cardiac surgery involving cardiotomy (not CABG) within the past 2 months Serum creatinine > 220 mmol/L (2.5 mg/dL) Thrombocytopenia or coagulopathy Contraindication to heparin | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 2.0-90.0, Aged elderly subjects over the age 65 years who had not received pneumococcal vaccination adult subjects under the age of 45 years (healthy volunteers with no previous history of pneumococcal vaccination) children subjects over the age of 2 years with no previous history of pneumococcal vaccination immunocompromised, asplenia, cancer, liver or renal failure, and history of hypersensitivity to vaccine | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Acute Coronary Syndrome Myocardial Infarction Unstable Angina Pectoris Patients with any episode > five minutes of chest pain being admitted to rule out acute coronary syndrome Positive initial troponin or CK-MB tests Diagnostic ECG changes (ST segment elevation or horizontal ST segment depression in more than two contiguous leads) Unstable clinical condition (hemodynamically unstable, ventricular tachycardia, persistent chest pain despite adequate therapy) Creatinine Clearance <50 mL/min Known allergy to iodinated contrast agents Patients on metformin therapy unable or unwilling to discontinue therapy for 48 hours after CT scan procedure Known asthma, reactive airway disease Patients currently in atrial fibrillation | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-999.0, Myocardial Reperfusion Injury clinical evidence of myocardial infarction defined by the presence of ischemic chest pain lasting more than 30 minutes, with a time interval from the onset of symptoms less than 6 hours before hospital admission, associated with typical ST-segment elevation on the 12-lead ECG angiographic-detected culprit lesion with stenosis diameter >70% and TIMI flow grade <=1 previous acute myocardial infarction previous myocardial revascularization (angioplasty or coronary bypass) previous heart valve replacement previous heart transplant clinical instability precluding the suitability of the study cardiogenic shock or persistent hypotension (systolic blood pressure <100 mmHg) rescue angioplasty after thrombolytic therapy evidence of coronary collaterals (Rentrop grade>0) in the risk area advanced atrioventricular block significant bradycardia | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 18.0-75.0, Cocaine Dependence meet DSM-IV for lifetime cocaine dependence and have used cocaine in the prior 6 months be > 18 years of age be judged clinically appropriate for IOP (e.g., no current psychotic disorder or evidence of severe dementia, and no acute medical problem requiring inpatient treatment have no regular IV heroin use during the past year have access to a telephone be willing to be randomized and participate in research; and no current participation in methadone or other forms of DA treatment, other than IOP. Finally, because of study follow-up requirements, subjects will be required to be metropolitan area residents, and be able to provide the name, verified telephone number, and address of at least two contacts who can provide locator information on the patient during follow-up. We will patients with dependence on other substances, provided that they are cocaine dependent and meet other criteria have a current psychotic disorder (as assessed with the psychotic screen from the MINI) or evidence of dementia severe enough to prevent participation in outpatient treatment have acute medical problem requiring immediate inpatient treatment; or are currently participating in methadone or other forms of DA treatment, other than IOP | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 19.0-999.0, Cardiovascular Risk Factors Age ≥ 65 years Hypertension (HTN) Diabetes Obesity (body mass index [BMI] >35) Renal insufficiency Tobacco usage Hypercholesterolemia Sleep apnea/heavy snoring at night Clinical diagnosis of CHF as defined by Dyspnea on exertion Patients expected to say in the hospital for less than 24 hours Inability of undergo TEE and TTE Clinical evidence or suspicion of elevated intracranial pressure Preoperative shock or systemic sepsis Emergency Operation ASA Class V Inability of give informed consent Participation in another clinical trial Prisoner | 0 |
An 82-year-old woman comes to the emergency department because of chest pain and shortness of breath after being awakened in the morning by stabbing substernal chest pain radiating to the left shoulder and jaw. The patient had hypertension, renal-artery stenosis with chronic renal insufficiency, hypercholesterolemia, osteoporosis and dementia. Blood pressure was 199/108 mm Hg, respiratory rate 18 bpm, oxygen saturation 98% on ambient air. The heart sounds were rapid and with no murmurs. CK-MB was 10.9 ng/ml, CK was 89 U/l, CK index was 12.2% and Troponin T was 0.40 ng/ml. An EKG showed sinus regular tachycardia of 119 bpm, with ST-segment elevations up to 3 mm in V1, V2, and V3. A chest radiograph showed low lung volumes and right basilar subsegmental atelectasis. Coronary angiography showed no stenosis or clinically significant disease. Left ventriculography revealed akinesis of the anterior wall, hypokinesis of the apical and distal inferior walls, and compensatory hyperkinesis of the basal anterior and basal inferior walls. A transthoracic echocardiogram showed severe segmental left ventricular dysfunction involving the septum, anteroseptal territory, and apex. The overall left ventricular systolic function was mildly impaired and there was mild mitral regurgitation. | eligible ages (years): 10.0-999.0, Primary Hypercholesterolemia and Homozygous Familial Hypercholesterolemia (HoFH) Participants Who Receives Vytorin In Usual Medical Practice Within Local Label For The First Time | 0 |
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