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nfcorpus-qrel-MED-5268 | Generate text that best answers this question: Olive Oil and Artery Function | Olive oil intake and CHD in the European Prospective Investigation into Cancer and Nutrition Spanish cohort.
Olive oil is well known for its cardioprotective properties; however, epidemiological data showing that olive oil consumption reduces incident CHD events are still limited. Therefore, we studied the association between olive oil and CHD in the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort study. The analysis included 40 142 participants (38 % male), free of CHD events at baseline, recruited from five EPIC-Spain centres from 1992 to 1996 and followed up until 2004. Baseline dietary and lifestyle information was collected using interview-administered questionnaires. Cox proportional regression models were used to assess the relationship between validated incident CHD events and olive oil intake (energy-adjusted quartiles and each 10 g/d per 8368 kJ (2000 kcal) increment), while adjusting for potential confounders. During a 10·4-year follow-up, 587 (79 % male) CHD events were recorded. Olive oil intake was negatively associated with CHD risk after excluding dietary mis-reporters (hazard ratio (HR) 0·93; 95 % CI 0·87, 1·00 for each 10 g/d per 8368 kJ (2000 kcal) and HR 0·78; 95 % CI 0·59, 1·03 for upper v. lower quartile). The inverse association between olive oil intake (per 10 g/d per 8368 kJ (2000 kcal)) and CHD was more pronounced in never smokers (11 % reduced CHD risk (P = 0·048)), in never/low alcohol drinkers (25 % reduced CHD risk (P < 0·001)) and in virgin olive oil consumers (14 % reduced CHD risk (P = 0·072)). In conclusion, olive oil consumption was related to a reduced risk of incident CHD events. This emphasises the need to conserve the traditional culinary use of olive oil within the Mediterranean diet to reduce the CHD burden. |
nfcorpus-qrel-MED-5269 | Generate text that best answers this question: Olive Oil and Artery Function | Olive, soybean and palm oils intake have a similar acute detrimental effect over the endothelial function in healthy young subjects.
BACKGROUND AND AIM: Currently, more than 30% of the caloric intake in the Colombian population comes from vegetable oil consumption mainly by the ingestion of deep-fried foods. Recently, it has been reported that unsaturated fatty acid rich oils have a beneficial effect on the endothelial function. Nevertheless, it is well know that the deep-frying process alters the chemical composition of vegetable oils and can produce adverse effects in the endothelial function. OBJECTIVE: To evaluate the acute effect of the ingestion of large amounts of olive, soybean and palm oils, fresh and at two different deep-fry levels, on the glucose and lipid profiles and the endothelial function. METHODS AND RESULTS: Ten healthy young volunteers were included in the study. After performing a baseline evaluation of cardiovascular risk factors and drawing a fasting blood sample, subjects were exposed to a randomly assigned potato soup meal containing 60 mL of one of three different vegetable oils (olive, soybean and palm), either fresh or at one of two different deep-fry levels (10 and 20 fries, respectively). Flow-mediated vasodilation (FMD) was performed in fasting conditions and 3h after the intake of the oil rich meal. Furthermore, blood samples were taken at these stages for the lipid profiles and plasma glucose determinations. All the meals resulted in a similar acute endothelial impairment (FMD decrease of 32.1%, confidence interval [CI] 95%, 28.0-36.2) and postprandial increase in triglycerides (27.03%, CI 95%, 20.5-33.3), independently of the type of oil ingested (p=0.44) and regardless of its deep-fry level (p=0.62). No correlation was found between endothelial impairment and postprandial triglyceride increment (r=-0.22, p=0.09). CONCLUSIONS: No difference was found in the acute adverse effect of the ingestion of different vegetable oils on the endothelial function. All the vegetable oils, fresh and deep-fried, produced an increase in the triglyceride plasma levels in healthy subjects. |
nfcorpus-qrel-MED-5270 | Generate text that best answers this question: Olive Oil and Artery Function | Diabetes and the Mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependen...
Abnormalities in endothelial function may be associated with increased cardiovascular risk in diabetic patients. We examined the effect of an oleic-acid-rich diet on insulin resistance and endothelium-dependent vasoreactivity in type 2 diabetes. Eleven type 2 diabetic patients were changed from their usual linoleic-acid-rich diet and treated for 2 months with an oleic-acid-rich diet. Insulin-mediated glucose transport was measured in isolated adipocytes. Fatty acid composition of the adipocyte membranes was determined by gas-liquid chromatography and flow-mediated endothelium-dependent and -independent vasodilatation were measured in the superficial femoral artery at the end of each dietary period. There was a significant increase in oleic acid and a decrease in linoleic acid on the oleic-acid-rich diet (p<0.0001). Diabetic control was not different between the diets, but there was a small but significant decrease in fasting glucose/insulin on the oleic-acid-rich diet. Insulin-stimulated (1 ng/ml) glucose transport was significantly greater on the oleic- acid-rich diet (0.56+/-0.17 vs. 0.29+/-0.14 nmol/10(5) cells/3 min, p<0.0001). Endothelium-dependent flow-mediated vasodilatation (FMD) was significantly greater on the oleic-acid-rich diet (3.90+/-0.97% vs. 6.12+/-1.36% p<0.0001). There was a significant correlation between adipocyte membrane oleic/linoleic acid and insulin-mediated glucose transport (p<0.001) but no relationship between insulin-stimulated glucose transport and change in endothelium-dependent FMD. There was a significant positive correlation between adipocyte membrane oleic/linoleic acid and endothelium-dependent FMD (r=0.61, p<0.001). Change from polyunsaturated to monounsaturated diet in type 2 diabetes reduced insulin resistance and restored endothelium-dependent vasodilatation, suggesting an explanation for the anti-atherogenic benefits of a Mediterranean-type diet. |
nfcorpus-qrel-MED-5271 | Generate text that best answers this question: Olive Oil and Artery Function | The postprandial effect of components of the Mediterranean diet on endothelial function.
OBJECTIVES: This study investigated the postprandial effect of components of the Mediterranean diet on endothelial function, which may be an atherogenic factor. BACKGROUND: The Mediterranean diet, containing olive oil, pasta, fruits, vegetables, fish, and wine, is associated with an unexpectedly low rate of cardiovascular events. The Lyon Diet Heart Study found that a Mediterranean diet, which substituted omega-3-fatty-acid-enriched canola oil for the traditionally consumed omega-9 fatty-acid-rich olive oil, reduced cardiovascular events. METHODS: We fed 10 healthy, normolipidemic subjects five meals containing 900 kcal and 50 g fat. Three meals contained different fat sources: olive oil, canola oil, and salmon. Two olive oil meals also contained antioxidant vitamins (C and E) or foods (balsamic vinegar and salad). We measured serum lipoproteins and glucose and brachial artery flow-mediated vasodilation (FMD), an index of endothelial function, before and 3 h after each meal. RESULTS: All five meals significantly raised serum triglycerides, but did not change other lipoproteins or glucose 3 h postprandially. The olive oil meal reduced FMD 31% (14.3 +/- 4.2% to 9.9 +/- 4.5%, p = 0.008). An inverse correlation was observed between postprandial changes in serum triglycerides and FMD (r = -0.47, p < 0.05). The remaining four meals did not significantly reduce FMD. CONCLUSIONS: In terms of their postprandial effect on endothelial function, the beneficial components of the Mediterranean and Lyon Diet Heart Study diets appear to be antioxidant-rich foods, including vegetables, fruits, and their derivatives such as vinegar, and omega-3-rich fish and canola oils. |
nfcorpus-qrel-MED-5272 | Generate text that best answers this question: Olive Oil and Artery Function | Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial...
Traditional cardiovascular risk factors are associated with endothelial dysfunction. The vascular endothelium plays a key role in local vascular tone regulation and can be modulated by dietary fat. We propose to determine the chronic effect of three diets with different fat compositions on postprandial endothelial function and inflammatory biomarkers. Twenty healthy men followed three 4-week diets in a randomised cross-over design: a Western diet, rich in saturated fat (22% SFA, 12% MUFA and 0.4% alpha-linolenic acid (ALA), all fractions are % of energy); a Mediterranean diet, rich in MUFA ( < 10 % SFA, 24 % MUFA and 0.4% ALA); a low-fat diet enriched in ALA ( < 10% SFA, 12% MUFA and 2% ALA). At the end of each dietary period all subjects underwent a postprandial study. Plasma concentrations of lipid parameters, soluble intercellular cell-adhesion molecule-1, soluble vascular cell-adhesion molecule-1 (sVCAM-1), nitrates and nitrites (NOx) and endothelial function studied by laser Doppler were examined at 0, 2, 4, 6 and 8 h. The endothelium-dependent vasodilatory response was greater 4 h after the ingestion of the MUFA-rich diet than after the SFA or ALA low-fat diets (P = 0.031). The 4 h postprandial plasma sVCAM-1 levels were lower after the MUFA meals than after the ALA low-fat diet (P = 0.043). The bioavailability of NOx was higher following the MUFA diet than after the SFA and ALA low-fat diets (P = 0.027). We found no differences in the other parameters measured. Chronic ingestion of a Mediterranean diet avoids the postprandial deterioration of endothelial function associated with Westernised diets in healthy individuals. |
nfcorpus-qrel-MED-5273 | Generate text that best answers this question: Olive Oil and Artery Function | Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures.
OBJECTIVE: The olive oil-rich Mediterranean diet protects against cardiovascular disease, which involves inflammatory processes. This study investigated the effects of phenolic compounds found in extra virgin olive oil on inflammatory mediator production by human mononuclear cells. METHODS: Diluted human blood cultures were stimulated with lipopolysaccharide in the presence of phenolics (vanillic, p-coumaric, syringic, homovanillic and caffeic acids, kaempferol, oleuropein glycoside, and tyrosol) at concentrations of 10(-7) to 10(-4) M. Concentrations of the inflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 and of the inflammatory eicosanoid prostaglandin E2 were measured by enzyme-linked immunosorbent assay. RESULTS: Oleuropein glycoside and caffeic acid decreased the concentration of interleukin-1beta. At a concentration of 10(-4) M, oleuropein glycoside inhibited interleukin-1beta production by 80%, whereas caffeic acid inhibited production by 40%. Kaempferol decreased the concentration of prostaglandin E2. At a concentration of 10(-4) M, kaempferol inhibited prostaglandin E2 production by 95%. No effects were seen on concentrations of interleukin-6 or tumor necrosis factor-alpha and there were no effects of the other phenolic compounds. CONCLUSIONS: Some, but not all, phenolic compounds derived from extra virgin olive oil decrease inflammatory mediator production by human whole blood cultures. This may contribute to the antiatherogenic properties ascribed to extra virgin olive oil. |
nfcorpus-qrel-MED-5274 | Generate text that best answers this question: Olive Oil and Artery Function | Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension.
BACKGROUND: Olive oil polyphenols have been associated with several cardiovascular health benefits. This study aims to examine the influence of a polyphenol-rich olive oil on blood pressure (BP) and endothelial function in 24 young women with high-normal BP or stage 1 essential hypertension. METHODS: We conducted a double-blind, randomized, crossover dietary-intervention study. After a run-in period of 4 months (baseline values), two diets were used, one with polyphenol-rich olive oil (∼30 mg/day), the other with polyphenol-free olive oil. Each dietary period lasted 2 months with a 4-week washout between diets. Systolic and diastolic BP, serum or plasma biomarkers of endothelial function, oxidative stress, and inflammation, and ischemia-induced hyperemia in the forearm were measured. RESULTS: When compared to baseline values, only the polyphenol-rich olive oil diet led to a significant (P < 0.01) decrease of 7.91 mm Hg in systolic and 6.65 mm Hg of diastolic BP. A similar finding was found for serum asymmetric dimethylarginine (ADMA) (-0.09 ± 0.01 µmol/l, P < 0.01), oxidized low-density lipoprotein (ox-LDL) (-28.2 ± 28.5 µg/l, P < 0.01), and plasma C-reactive protein (CRP) (-1.9 ± 1.3 mg/l, P < 0.001). The polyphenol-rich olive oil diet also elicited an increase in plasma nitrites/nitrates (+4.7 ± 6.6 µmol/l, P < 0.001) and hyperemic area after ischemia (+345 ± 386 perfusion units (PU)/sec, P < 0.001). CONCLUSIONS: We concluded that the consumption of a diet containing polyphenol-rich olive oil can decrease BP and improve endothelial function in young women with high-normal BP or stage 1 essential hypertension. |
nfcorpus-qrel-MED-1401 | Generate text that best answers this question: Olive Oil and Artery Function | Dietary Iron Intake and Body Iron Stores Are Associated with Risk of Coronary Heart Disease in a Meta-Analysis of Prospective Cohort Studies
The link between iron intake as well as body iron stores and coronary heart disease (CHD) has been contentiously debated, and the epidemiologic evidence is inconsistent. We aimed to quantitatively summarize the literature on the association between dietary iron intake/body iron stores and CHD risk by conducting a meta-analysis of prospective cohort studies. PubMed was used to find studies published through June 2013 in peer-reviewed journals. Embase or a hand search of relevant articles was used to obtain additional articles. The pooled RRs of CHD incidence and mortality with 95% CIs were calculated by using either a random-effects or fixed-effects model, as appropriate. Twenty-one eligible studies (32 cohorts) including 292,454 participants with an average of 10.2 y of follow-up were included. Heme iron was found to be positively associated with CHD incidence (RR: 1.57; 95% CI: 1.28, 1.94), whereas total iron was inversely associated (RR: 0.85; 95% CI: 0.73, 0.999). Neither heme-iron nor total iron intakes were significantly associated with CHD mortality. Both transferrin saturation and serum iron were inversely related to CHD incidence [RR (95% CI): 0.76 (0.66, 0.88) and 0.68 (0.56, 0.82), respectively], but only transferrin saturation was inversely associated with CHD mortality (RR: 0.85; 95% CI: 0.73, 0.99). In conclusion, total iron intake and serum iron concentrations were inversely associated with CHD incidence, but heme iron intake was positively related to CHD incidence. Elevated serum transferrin saturation concentration was inversely associated with both CHD incidence and mortality. Future research is needed to establish the causal relation and to elucidate potential mechanisms. |
nfcorpus-qrel-MED-1402 | Generate text that best answers this question: Olive Oil and Artery Function | Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score.
OBJECTIVE: To update previous meta-analyses of cohort studies that investigated the association between the Mediterranean diet and health status and to utilize data coming from all of the cohort studies for proposing a literature-based adherence score to the Mediterranean diet. DESIGN: We conducted a comprehensive literature search through all electronic databases up to June 2013. SETTING: Cohort prospective studies investigating adherence to the Mediterranean diet and health outcomes. Cut-off values of food groups used to compute the adherence score were obtained. SUBJECTS: The updated search was performed in an overall population of 4 172 412 subjects, with eighteen recent studies that were not present in the previous meta-analyses. RESULTS: A 2-point increase in adherence score to the Mediterranean diet was reported to determine an 8 % reduction of overall mortality (relative risk = 0·92; 95 % CI 0·91, 0·93), a 10 % reduced risk of CVD (relative risk = 0·90; 95 % CI 0·87, 0·92) and a 4 % reduction of neoplastic disease (relative risk = 0·96; 95 % CI 0·95, 0·97). We utilized data coming from all cohort studies available in the literature for proposing a literature-based adherence score. Such a score ranges from 0 (minimal adherence) to 18 (maximal adherence) points and includes three different categories of consumption for each food group composing the Mediterranean diet. CONCLUSIONS: The Mediterranean diet was found to be a healthy dietary pattern in terms of morbidity and mortality. By using data from the cohort studies we proposed a literature-based adherence score that can represent an easy tool for the estimation of adherence to the Mediterranean diet also at the individual level. |
nfcorpus-qrel-MED-1366 | Generate text that best answers this question: Olive Oil and Artery Function | Mediterranean diet and public health: personal reflections.
My concern about diet as a public health problem began in the early 1950s in Naples, where we observed very low incidences of coronary heart disease associated with what we later came to call the "good Mediterranean diet." The heart of this diet is mainly vegetarian, and differs from American and northern European diets in that it is much lower in meat and dairy products and uses fruit for dessert. These observations led to our subsequent research in the Seven Countries Study, in which we demonstrated that saturated fat is the major dietary villain. Today, the healthy Mediterranean diet is changing and coronary heart disease is no longer confined to medical textbooks. Our challenge is to persuade children to tell their parents to eat as Mediterraneans do. |
nfcorpus-qrel-MED-1403 | Generate text that best answers this question: Olive Oil and Artery Function | Heme iron intake and risk of new-onset diabetes in a Mediterranean population at high risk of cardiovascular disease: an observational cohort analysis
Background Several epidemiological studies have observed an increased risk of type 2 diabetes mellitus (T2DM) among subjects with a higher consumption of red and processed meat. Heme iron intake has been directly associated with a higher risk of T2DM in healthy adult Chinese and U.S populations. The objective of the present study was to evaluate the association between heme iron intake and the incidence of T2DM in a Mediterranean population at high cardiovascular risk. Methods We assessed a subset of participants in the PREDIMED trial as an observational cohort, followed up for a maximum of eight years. We initially included 1073 non-diabetic subjects (57.1% women) aged 67.3 ± 6.0 years, at high cardiovascular risk. Diet was assessed at the study baseline using a validated, semi-quantitative food frequency questionnaire. Results During the follow-up period 131 diabetics were newly diagnosed. The risk of developing T2DM was assessed using baseline heme iron intake and proportional hazard models, first unadjusted, then adjusted for energy, and finally adjusted for dietary, anthropometric, socio-demographic and lifestyle variables. Significant direct associations with the incidence of T2DM were found for heme iron (Hazard Ratio [HR] 1.30, 95% confidence interval [CI], 1.02 to 1.66). Secondarily, we have also observed that coffee (HR:0.93, 95% CI, 0.89 to 0.98) and alcoholic beverages (HR: 1.02, 95% CI, 1.01 to 1.04) were also found to reduce and increase the risk of T2DM, respectively. Conclusion High dietary intake of heme iron was associated with an increased risk of developing T2DM in a Mediterranean population at high cardiovascular risk. Trial registration Identifier: ISRCTN35739639. |
nfcorpus-qrel-MED-1404 | Generate text that best answers this question: Olive Oil and Artery Function | The effect of Mediterranean diet on the development of type 2 diabetes mellitus: a meta-analysis of 10 prospective studies and 136,846 participants.
OBJECTIVE: The purpose of this work was to meta-analyze prospective studies that have evaluated the effect of a Mediterranean diet on the development of type 2 diabetes. MATERIALS/METHODS: PubMed, Embase and the Cochrane Central Register of Controlled Trials databases were searched up to 20 November 2013. English language publications were allocated; 17 original research studies (1 clinical trial, 9 prospective and 7 cross-sectional) were identified. Primary analyses were limited to prospective studies and clinical trials, yielding to a sample of 136,846 participants. A systematic review and a random effects meta-analysis were conducted. RESULTS: Higher adherence to the Mediterranean diet was associated with 23% reduced risk of developing type 2 diabetes (combined relative risk for upper versus lowest available centile: 0.77; 95% CI: 0.66, 0.89). Subgroup analyses based on region, health status of participants and number of confounders controlling for, showed similar results. Limitations include variations in Mediterranean diet adherence assessment tools, confounders' adjustment, duration of follow up and number of events with diabetes. CONCLUSIONS: The presented results are of major public health importance, since no consensus exists concerning the best anti-diabetic diet. Mediterranean diet could, if appropriately adjusted to reflect local food availability and individual's needs, constitute a beneficial nutritional choice for the primary prevention of diabetes. Copyright © 2014 Elsevier Inc. All rights reserved. |
nfcorpus-qrel-MED-1405 | Generate text that best answers this question: Olive Oil and Artery Function | Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial
Background Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance. However, no previous epidemiological studies have evaluated the relationship between the intake of total polyphenols intake and polyphenol subclasses with overall mortality. Our aim was to evaluate whether polyphenol intake is associated with all-cause mortality in subjects at high cardiovascular risk. Methods We used data from the PREDIMED study, a 7,447-participant, parallel-group, randomized, multicenter, controlled five-year feeding trial aimed at assessing the effects of the Mediterranean Diet in primary prevention of cardiovascular disease. Polyphenol intake was calculated by matching food consumption data from repeated food frequency questionnaires (FFQ) with the Phenol-Explorer database on the polyphenol content of each reported food. Hazard ratios (HR) and 95% confidence intervals (CI) between polyphenol intake and mortality were estimated using time-dependent Cox proportional hazard models. Results Over an average of 4.8 years of follow-up, we observed 327 deaths. After multivariate adjustment, we found a 37% relative reduction in all-cause mortality comparing the highest versus the lowest quintiles of total polyphenol intake (hazard ratio (HR) = 0.63; 95% CI 0.41 to 0.97; P for trend = 0.12). Among the polyphenol subclasses, stilbenes and lignans were significantly associated with reduced all-cause mortality (HR =0.48; 95% CI 0.25 to 0.91; P for trend = 0.04 and HR = 0.60; 95% CI 0.37 to 0.97; P for trend = 0.03, respectively), with no significant associations apparent in the rest (flavonoids or phenolic acids). Conclusions Among high-risk subjects, those who reported a high polyphenol intake, especially of stilbenes and lignans, showed a reduced risk of overall mortality compared to those with lower intakes. These results may be useful to determine optimal polyphenol intake or specific food sources of polyphenols that may reduce the risk of all-cause mortality. Clinical trial registration ISRCTN35739639. |
nfcorpus-qrel-MED-1406 | Generate text that best answers this question: Olive Oil and Artery Function | Dietary magnesium intake is inversely associated with mortality in adults at high cardiovascular disease risk.
The relation between dietary magnesium intake and cardiovascular disease (CVD) or mortality was evaluated in several prospective studies, but few of them have assessed the risk of all-cause mortality, which has never been evaluated in Mediterranean adults at high cardiovascular risk. The aim of this study was to assess the association between magnesium intake and CVD and mortality risk in a Mediterranean population at high cardiovascular risk with high average magnesium intake. The present study included 7216 men and women aged 55-80 y from the PREDIMED (Prevención con Dieta Mediterránea) study, a randomized clinical trial. Participants were assigned to 1 of 2 Mediterranean diets (supplemented with nuts or olive oil) or to a control diet (advice on a low-fat diet). Mortality was ascertained by linkage to the National Death Index and medical records. We fitted multivariable-adjusted Cox regressions to assess associations between baseline energy-adjusted tertiles of magnesium intake and relative risk of CVD and mortality. Multivariable analyses with generalized estimating equation models were used to assess the associations between yearly repeated measurements of magnesium intake and mortality. After a median follow-up of 4.8 y, 323 total deaths, 81 cardiovascular deaths, 130 cancer deaths, and 277 cardiovascular events occurred. Energy-adjusted baseline magnesium intake was inversely associated with cardiovascular, cancer, and all-cause mortality. Compared with lower consumers, individuals in the highest tertile of magnesium intake had a 34% reduction in mortality risk (HR: 0.66; 95% CI: 0.45, 0.95; P < 0.01). Dietary magnesium intake was inversely associated with mortality risk in Mediterranean individuals at high risk of CVD. This trial was registered at controlled-trials.com as ISRCTN35739639. |
nfcorpus-qrel-MED-1407 | Generate text that best answers this question: Olive Oil and Artery Function | The Mediterranean Diet: A History of Health
The Mediterranean tradition offers a cousine rich in colors, aromas and memories, which support the taste and the spirit of those who live in harmony with nature. Everyone is talking about the Mediterranean diet, but few are those who do it properly, thus generating a lot of confusion in the reader. And so for some it coincides with the pizza, others identified it with the noodles with meat sauce, in a mixture of pseudo historical traditions and folklore that do not help to solve the question that is at the basis of any diet: combine and balance the food so as to satisfy the qualitative and quantitative needs of an individual and in a sense, preserves his health through the use of substances that help the body to perform normal vital functions. The purpose of our work is to demonstrate that the combination of taste and health is a goal that can be absolutely carried out by everybody, despite those who believe that only a generous caloric intake can guarantee the goodness of a dish and the satisfaction of the consumers. That should not be an absolute novelty, since the sound traditions of the Mediterranean cuisine we have used for some time in a wide variety of tasty gastronomic choices, from inviting colors and strong scents and absolutely in line with health. |
nfcorpus-qrel-MED-1408 | Generate text that best answers this question: Olive Oil and Artery Function | Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis.
OBJECTIVE: This meta-analysis aims to quantitatively synthesize all studies that examine the association between adherence to a Mediterranean diet and risk of stroke, depression, cognitive impairment, and Parkinson disease. METHODS: Potentially eligible publications were those providing effect estimates of relative risk (RR) for the association between Mediterranean diet and the aforementioned outcomes. Studies were sought in PubMed up to October 31, 2012. Maximally adjusted effect estimates were extracted; separate analyses were performed for high and moderate adherence. RESULTS: Twenty-two eligible studies were included (11 covered stroke, 9 covered depression, and 8 covered cognitive impairment; only 1 pertained to Parkinson's disease). High adherence to Mediterranean diet was consistently associated with reduced risk for stroke (RR = 0.71, 95% confidence interval [CI] = 0.57-0.89), depression (RR = 0.68, 95% CI = 0.54-0.86), and cognitive impairment (RR = 0.60, 95% CI = 0.43-0.83). Moderate adherence was similarly associated with reduced risk for depression and cognitive impairment, whereas the protective trend concerning stroke was only marginal. Subgroup analyses highlighted the protective actions of high adherence in terms of reduced risk for ischemic stroke, mild cognitive impairment, dementia, and particularly Alzheimer disease. Meta-regression analysis indicated that the protective effects of Mediterranean diet in stroke prevention seemed more sizeable among males. Concerning depression, the protective effects of high adherence seemed independent of age, whereas the favorable actions of moderate adherence seemed to fade away with more advanced age. INTERPRETATION: Adherence to a Mediterranean diet may contribute to the prevention of a series of brain diseases; this may be of special value given the aging of Western societies. © 2013 American Neurological Association. |
nfcorpus-qrel-MED-1409 | Generate text that best answers this question: Olive Oil and Artery Function | Changing prevalence of coronary heart disease risk factors and cardiovascular diseases in men of a rural area of Crete from 1960 to 1991.
This study compares the prevalence of coronary heart disease (CHD), risk factors (RF), and cardiovascular diseases (CVD) among Cretan men from a rural area examined in 1960 and 1991. The study population consisted of 148 men in 1960 and 42 men in 1991 of the same age group (fifty-five to fifty-nine years old) and from the same rural area. All men had a complete examination of the cardiovascular system and a resting electrocardiogram (ECG). Systolic BP (SBP) > or = 140 mmHg was found in 42.6% of the subjects in 1960 and in 45.2% in 1991 (NS). Diastolic BP > or = 95 mmHG was found in 14.9% of the subjects in 1960 as opposed to 33.3% in 1991 (P < 0.02). Total serum cholesterol (TSCH) > or = 260 mg/dL approximately 6.7 mmol/L) was found in 12.8% of the subjects in 1960 and in 28.6% in 1991 (P < 0.01). Heavy smokers ( > or = 20 cigarettes/daily) were 27.0% in 1960 as compared with 35.7% in 1991 (:NS); 5.4% of the subjects in 1960 had light physical activity (PA) as compared with 14.3% in 1991 (P < 0.01); 74.7% of the subjects were farmers in 1960 as compared with 43.6% in 1991 (P < 0.1). The prevalence of CHD was 0.7% in 1960 as compared with 9.5% in 1991 (P < 0.001). Hypertensive heart disease was found in 3.4% of the subjects in 1960 and 4.8% in 1991 (NS). The prevalence of all major CVD was much higher in 1991 (19.1%) as compared with 1960 (8.8%) (P < 0.01). In conclusion, the prevalence of CHD RF and CVD was much higher in 1991 than in 1960 for Cretan men of the same age group. This higher prevalence seems to be related to dietary and life-style changes that have taken place in Crete during the last thirty years. |
nfcorpus-qrel-MED-1410 | Generate text that best answers this question: Olive Oil and Artery Function | The diet and 15-year death rate in the seven countries study.
In 15 cohorts of the Seven Countries Study, comprising 11,579 men aged 40-59 years and "healthy" at entry, 2,288 died in 15 years. Death rates differed among cohorts. Differences in mean age, blood pressure, serum cholesterol, and smoking habits "explained" 46% of variance in death rate from all causes, 80% from coronary heart disease, 35% from cancer, and 45% from stroke. Death rate differences were unrelated to cohort differences in mean relative body weight, fatness, and physical activity. The cohorts differed in average diets. Death rates were related positively to average percentage of dietary energy from saturated fatty acids, negatively to dietary energy percentage from monounsaturated fatty acids, and were unrelated to dietary energy percentage from polyunsaturated fatty acids, proteins, carbohydrates, and alcohol. All death rates were negatively related to the ratio of monounsaturated to saturated fatty acids. Inclusion of that ratio with age, blood pressure, serum cholesterol, and smoking habits as independent variables accounted for 85% of variance in rates of deaths from all causes, 96% coronary heart disease, 55% cancer, and 66% stroke. Oleic acid accounted for almost all differences in monounsaturates among cohorts. All-cause and coronary heart disease death rates were low in cohorts with olive oil as the main fat. Causal relationships are not claimed but consideration of characteristics of populations as well as of individuals within populations is urged in evaluating risks. |
nfcorpus-qrel-MED-1411 | Generate text that best answers this question: Olive Oil and Artery Function | The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals.
OBJECTIVES: The aim of this study was to meta-analyze epidemiological studies and clinical trials that have assessed the effect of a Mediterranean diet on metabolic syndrome (MS) as well as its components. BACKGROUND: The Mediterranean diet has long been associated with low cardiovascular disease risk in adult population. METHODS: The authors conducted a systematic review and random effects meta-analysis of epidemiological studies and randomized controlled trials, including English-language publications in PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials until April 30, 2010; 50 original research studies (35 clinical trials, 2 prospective and 13 cross-sectional), with 534,906 participants, were included in the analysis. RESULTS: The combined effect of prospective studies and clinical trials showed that adherence to the Mediterranean diet was associated with reduced risk of MS (log hazard ratio: -0.69, 95% confidence interval [CI]: -1.24 to -1.16). Additionally, results from clinical studies (mean difference, 95% CI) revealed the protective role of the Mediterranean diet on components of MS, like waist circumference (-0.42 cm, 95% CI: -0.82 to -0.02), high-density lipoprotein cholesterol (1.17 mg/dl, 95% CI: 0.38 to 1.96), triglycerides (-6.14 mg/dl, 95% CI: -10.35 to -1.93), systolic (-2.35 mm Hg, 95% CI: -3.51 to -1.18) and diastolic blood pressure (-1.58 mm Hg, 95% CI: -2.02 to -1.13), and glucose (-3.89 mg/dl, 95% CI:-5.84 to -1.95), whereas results from epidemiological studies also confirmed those of clinical trials. CONCLUSIONS: These results are of considerable public health importance, because this dietary pattern can be easily adopted by all population groups and various cultures and cost-effectively serve for primary and secondary prevention of the MS and its individual components. Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
nfcorpus-qrel-MED-1634 | Generate text that best answers this question: Olive Oil and Artery Function | Cardiovascular disease data to be standardized across Europe.
ESC is to create an inventory of cardiovascular disease registries and a task force on data standardization |
nfcorpus-qrel-MED-1635 | Generate text that best answers this question: Olive Oil and Artery Function | Tea Consumption Enhances Endothelial-Dependent Vasodilation; a Meta-Analysis
Background Tea consumption is associated with a lower risk of cardiovascular disease including stroke. Direct effects of tea components on the vasculature, particularly the endothelium, may partly explain this association. Objective We performed a meta-analysis of controlled human intervention studies on the effect of tea on flow-mediated dilation (FMD) of the brachial artery, a measurement of endothelial function, which is suggested to be associated with cardiovascular risk. Methods Human intervention studies were identified by systematic search of the databases Medline, Embase, Chemical s and Biosis through March 2009 and by hand-searching related articles. Studies were selected based on predefined criteria: intervention with tea as the sole experimental variable, placebo-controlled design, and no missing data on FMD outcome or its variability. A random effects model was used to calculate the pooled overall effect on FMD due to the intake of tea. The impact of various subject and treatment characteristics was investigated in the presence of heterogeneity. Results In total, 9 studies from different research groups were included with 15 relevant study arms. The overall absolute increase in FMD of tea vs. placebo was 2.6% of the arterial diameter (95% CI: 1.8-3.3%; P-value <0.001) for a median daily dose of 500 mL of tea (2–3 cups). This is a relative increase of approximately 40% compared to the average FMD of 6.3% measured under placebo or baseline conditions. There was significant heterogeneity between studies (P-value <0.001) that might partly be explained by the cuff position either distal or proximal to the area of FMD measurement. No indication for publication bias was found. Conclusion Moderate consumption of tea substantially enhances endothelial-dependent vasodilation. This may provide a mechanistic explanation for the reduced risk of cardiovascular events and stroke observed among tea drinkers. |
nfcorpus-qrel-MED-1636 | Generate text that best answers this question: Olive Oil and Artery Function | Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials.
Coffee drinking has been associated with increased serum cholesterol levels in some, but not all, studies. A Medline search of the English-language literature published prior to December 1998, a bibliography review, and consultations with experts were performed to identify 14 published trials of coffee consumption. Information was abstracted independently by two reviewers using a standardized protocol. With a random-effects model, treatment effects were estimated by pooling results from individual trials after weighting the results by the inverse of total variance. A dose-response relation between coffee consumption and both total cholesterol and LDL cholesterol was identified (p < 0.01). Increases in serum lipids were greater in studies of patients with hyperlipidemia and in trials of caffeinated or boiled coffee. Trials using filtered coffee demonstrated very little increase in serum cholesterol. Consumption of unfiltered, but not filtered, coffee increases serum levels of total and LDL cholesterol. |
nfcorpus-qrel-MED-1637 | Generate text that best answers this question: Olive Oil and Artery Function | Black tea increases coronary flow velocity reserve in healthy male subjects.
Epidemiologic studies suggest that tea consumption decreases the risk for cardiovascular events. However, there has been no clinical report examining the effects of tea consumption on coronary circulation. The purpose of this study was to evaluate the effects of black tea on coronary flow velocity reserve (CFVR) using transthoracic Doppler echocardiography (TTDE). This was a double-blind crossover study of 10 healthy male volunteers conducted to compare the effects of black tea and caffeine on coronary circulation. The coronary flow velocity of the left anterior descending coronary artery was measured at baseline and at hyperemia during adenosine triphosphate infusion by TTDE to determine CFVR. The CFVR ratio was defined as the ratio of CFVR after beverage consumption to CFVR before beverage consumption. All data were divided into 2 groups according to beverage type: group T (black tea) and group C (caffeine). Two-way analysis of variance showed a significant group effect and interaction in CFVR before and after beverage consumption (p = 0.001). CFVR significantly increased after tea consumption in group T (4.5 +/- 0.9 vs 5.2 +/- 0.9, p <0.0001). The CFVR ratio of group T was larger than that of group C (1.18 +/- 0.07 vs 1.04 +/- 0.08, p = 0.002). Acute black tea consumption improves coronary vessel function, as determined by CFVR. |
nfcorpus-qrel-MED-1638 | Generate text that best answers this question: Olive Oil and Artery Function | Caffeine enhances endothelial repair by an AMPK-dependent mechanism.
OBJECTIVE: Migratory capacity of endothelial progenitor cells (EPCs) and mature endothelial cells (ECs) is a key prerequisite for endothelial repair after denuding injury or endothelial damage. METHODS AND RESULTS: We demonstrate that caffeine in physiologically relevant concentrations (50 to 100 micromol/L) induces migration of human EPCs as well as mature ECs. In patients with coronary artery disease (CAD), caffeinated coffee increased caffeine serum concentration from 2 micromol/L to 23 micromol/L, coinciding with a significant increase in migratory activity of patient-derived EPCs. Decaffeinated coffee neither affected caffeine serum levels nor migratory capacity of EPCs. Treatment with caffeine for 7 to 10 days in a mouse-model improved endothelial repair after denudation of the carotid artery. The enhancement of reendothelialization by caffeine was significantly reduced in AMPK knockout mice compared to wild-type animals. Transplantation of wild-type and AMPK(-/-) bone marrow into wild-type mice revealed no difference in caffeine challenged reendothelialization. ECs which were depleted of mitochondrial DNA did not migrate when challenged with caffeine, suggesting a potential role for mitochondria in caffeine-dependent migration. CONCLUSIONS: These results provide evidence that caffeine enhances endothelial cell migration and reendothelialization in part through an AMPK-dependent mechanism, suggesting a beneficial role for caffeine in endothelial repair. |
nfcorpus-qrel-MED-1639 | Generate text that best answers this question: Olive Oil and Artery Function | Impact of acute caffeine ingestion on endothelial function in subjects with and without coronary artery disease.
Although coffee is a widely used, pharmacologically active beverage, its impact on the cardiovascular system is controversial. To explore the effect of acute caffeine ingestion on brachial artery flow-mediated dilation (FMD) in subjects without coronary artery disease (CAD; controls) and patients with CAD, we prospectively assessed brachial artery FMD in 40 controls and 40 age- and gender-matched patients with documented stable CAD on 2 separate mornings 1 week to 2 weeks apart. After overnight fasting, discontinuation of all medications for ≥12 hours, and absence of caffeine for >48 hours, participants received capsules with caffeine 200 mg or placebo. One hour after drug ingestion, participants underwent brachial artery FMD and nitroglycerin-mediated dilation (NTG) using high-resolution ultrasound. As expected, patients with CAD were more often diabetic, hypertensive, obese, dyslipidemic, and smoked more than controls (p <0.01 for all comparisons). Aspirin, Clopidogrel, angiotensin-converting enzyme inhibitors, β blockers, and statins were significantly more common in patients with CAD than in controls (p <0.01 for all comparisons). At baseline, FMD, but not NTG, was significantly lower in patients with CAD compared to controls. Acute caffeine ingestion significantly increased FMD (patients with CAD 5.6 ± 5.0% vs 14.6 ± 5.0%, controls 8.4 ± 2.9% vs 18.6 ± 6.8%, p <0.001 for all comparisons) but not NTG (patients with CAD 13.0 ± 5.2% vs 13.8 ± 6.1%, controls 12.9 ± 3.9% vs 13.9 ± 5.8%, p = NS for all comparisons) and significantly decreased high-sensitivity C-reactive protein (patients with CAD 2.6 ± 1.4 vs 1.4 ± 1.2 mg/L, controls 3.4 ± 3.0 vs 1.2 ± 1.0 mg/L, p <0.001 for all comparisons) in the 2 groups compared to placebo. In conclusion, acute caffeine ingestion significantly improved endothelial function assessed by brachial artery FMD in subjects with and without CAD and was associated with lower plasma markers of inflammation. Copyright © 2011 Elsevier Inc. All rights reserved. |
nfcorpus-qrel-MED-1640 | Generate text that best answers this question: Olive Oil and Artery Function | Effect of coffee on endothelial function in healthy subjects: the role of caffeine.
Coffee is one of the most widely used pharmacologically active beverages. The present study was designed to evaluate the acute effect of coffee ingestion on endothelial function in healthy individuals, and the potential role of caffeine. We studied 17 healthy young adults (28.9+/-3.0 years old; nine men), who were regular non-heavy coffee drinkers. The endothelial performance was estimated by endothelium-dependent FMD (flow-mediated dilatation) of the brachial artery before and 30, 60, 90 and 120 min after ingestion of a cup of caffeinated coffee (80 mg of caffeine) or the corresponding decaffeinated beverage (< 2 mg of caffeine) in two separate sessions, following a randomized single-blind cross-over design. There was no difference in baseline FMD values between the two sessions [7.78 compared with 7.07% after caffeinated and decaffeinated coffee respectively; P = NS (not significant)]. Caffeinated coffee led to a decline of FMD (7.78, 2.86, 2.12, 4.44 and 4.57% at baseline, 30, 60, 90 and 120 min respectively; P < 0.001). This adverse effect was focused at 30 (P = 0.004) and 60 min (P < 0.001). No significant effect on FMD was found with the decaffeinated coffee session (7.07, 6.24, 5.21, 7.41 and 5.20%; P = NS). The composite effect of the type of coffee consumed over time on FMD was significantly different (P = 0.021). In conclusion, coffee exerts an acute unfavourable effect on the endothelial function in healthy adults, lasting for at least 1 h after intake. This effect might be attributed to caffeine, given that decaffeinated coffee was not associated with any change in the endothelial performance. |
nfcorpus-qrel-MED-1641 | Generate text that best answers this question: Olive Oil and Artery Function | Caffeine Impairs Myocardial Blood Flow Response to Physical Exercise in Patients with Coronary Artery Disease as well as in Age-Matched Controls
Background Caffeine is one of the most widely consumed pharmacologically active substances. Its acute effect on myocardial blood flow is widely unknown. Our aim was to assess the acute effect of caffeine in a dose corresponding to two cups of coffee on myocardial blood flow (MBF) in coronary artery disease (CAD). Methodology/Principal Findings MBF was measured with 15O-labelled H2O and Positron Emission Tomography (PET) at rest and after supine bicycle exercise in controls (n = 15, mean age 58±13 years) and in CAD patients (n = 15, mean age 61±9 years). In the latter, regional MBF was assessed in segments subtended by stenotic and remote coronary arteries. All measurements were repeated fifty minutes after oral caffeine ingestion (200 mg). Myocardial perfusion reserve (MPR) was calculated as ratio of MBF during bicycle stress divided by MBF at rest. Resting MBF was not affected by caffeine in both groups. Exercise-induced MBF response decreased significantly after caffeine in controls (2.26±0.56 vs. 2.02±0.56, P<0.005), remote (2.40±0.70 vs. 1.78±0.46, P<0.001) and in stenotic segments (1.90±0.41 vs. 1.38±0.30, P<0.001). Caffeine decreased MPR significantly by 14% in controls (P<0.05 vs. baseline). In CAD patients MPR decreased by 18% (P<0.05 vs. baseline) in remote and by 25% in stenotic segments (P<0.01 vs. baseline). Conclusions We conclude that caffeine impairs exercise-induced hyperaemic MBF response in patients with CAD to a greater degree than age-matched controls. |
nfcorpus-qrel-MED-1642 | Generate text that best answers this question: Olive Oil and Artery Function | Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects.
BACKGROUND/OBJECTIVES: Coffee is known to contain antioxidant substances whose effects may be blunted because of caffeine that may unfavorably affect the cardiovascular system. This study was designed to investigate the acute dose-dependent effects of decaffeinated coffee (DC) on endothelial function measured by the brachial artery flow-mediated dilation (FMD). SUBJECTS/METHODS: A total of 15 (8 men and 7 women) healthy nonobese subjects underwent a single-blind, crossover study. Subjects ingested one and two cups of decaffeinated Italian espresso coffee in random order at 5- to 7-day intervals. RESULTS: In the hour following the ingestion of two cups of DC, FMD increased (mean+/-s.e.m.): 0 min, 7.4+/-0.7%; 30 min, 8.0+/-0.6%; 60 min, 10.8+/-0.8%; P<0.001) as compared to consumption of one cup of DC (0 min, 6.9+/-0.7%; 30 min, 8.4+/-1.2%; 60 min, 8.5+/-1.1%; 3 x 2 repeated-measures analysis of variance: P=0.037 for time x treatment effect). Blood pressure did not differ between groups, and basal heart rate was lower in the two-cup group at baseline and 60 min. CONCLUSIONS: The present study demonstrated a significant acute favorable dose-dependent effect of decaffeinated espresso coffee on endothelial function. Further studies are needed to investigate the effects of chronic use of DC especially with respect to caffeinated coffee and in subjects with cardiovascular diseases. |
nfcorpus-qrel-MED-1643 | Generate text that best answers this question: Olive Oil and Artery Function | Does a glass of red wine improve endothelial function?
AIMS: To examine the acute effect of red wine and de-alcoholized red wine on endothelial function. METHODS AND RESULTS: High frequency ultrasound was used to measure blood flow and percentage brachial artery dilatation after reactive hyperaemia induced by forearm cuff occlusion in 12 healthy subjects, less than 40 years of age, without known cardiovascular risk factors. The subjects drank 250 ml of red wine with or without alcohol over 10 min according to a randomized procedure. Brachial artery dilatation was measured again 30 and 60 min after the subjects had finished drinking. The subjects were studied a second time within a week of the first study in a cross-over design. After the red wine with alcohol the resting brachial artery diameter, resting blood flow, heart rate and plasma-ethanol increased significantly. After the de-alcoholized red wine these parameters were unchanged. Flow-mediated dilatation of the brachial artery was significantly higher (P<0.05) after drinking de-alcoholized red wine (5.6+/-3.2%) than after drinking red wine with alcohol (3.6+/-2.2%) and before drinking (3.9+/-2.5%). CONCLUSION: After ingestion of red wine with alcohol the brachial artery dilated and the blood flow increased. These changes were not observed following the de-alcoholized red wine and were thus attributable to ethanol. These haemodynamic changes may have concealed an effect on flow-mediated brachial artery dilatation which did not increase after drinking red wine with alcohol. Flow-mediated dilatation of the brachial artery increased significantly after de-alcoholized red wine and this finding may support the hypothesis that antioxidant qualities of red wine, rather than ethanol in itself, may protect against cardiovascular disease. Copyright 2000 The European Society of Cardiology. |
nfcorpus-qrel-MED-5258 | Generate text that best answers this question: Olive Oil and Artery Function | Association of Coffee Drinking with Total and Cause-Specific Mortality
Background Coffee is one of the most widely consumed beverages, but the association between coffee consumption and the risk of death remains unclear. Methods We examined the association of coffee drinking with subsequent total and cause-specific mortality among 229,119 men and 173,141 women in the National Institutes of Health–AARP Diet and Health Study who were 50 to 71 years of age at baseline. Participants with cancer, heart disease, and stroke were excluded. Coffee consumption was assessed once at baseline. Results During 5,148,760 person-years of follow-up between 1995 and 2008, a total of 33,731 men and 18,784 women died. In age-adjusted models, the risk of death was increased among coffee drinkers. However, coffee drinkers were also more likely to smoke, and, after adjustment for tobacco-smoking status and other potential confounders, there was a significant inverse association between coffee consumption and mortality. Adjusted hazard ratios for death among men who drank coffee as compared with those who did not were as follows: 0.99 (95% confidence interval [CI], 0.95 to 1.04) for drinking less than 1 cup per day, 0.94 (95% CI, 0.90 to 0.99) for 1 cup, 0.90 (95% CI, 0.86 to 0.93) for 2 or 3 cups, 0.88 (95% CI, 0.84 to 0.93) for 4 or 5 cups, and 0.90 (95% CI, 0.85 to 0.96) for 6 or more cups of coffee per day (P<0.001 for trend); the respective hazard ratios among women were 1.01 (95% CI, 0.96 to 1.07), 0.95 (95% CI, 0.90 to 1.01), 0.87 (95% CI, 0.83 to 0.92), 0.84 (95% CI, 0.79 to 0.90), and 0.85 (95% CI, 0.78 to 0.93) (P<0.001 for trend). Inverse associations were observed for deaths due to heart disease, respiratory disease, stroke, injuries and accidents, diabetes, and infections, but not for deaths due to cancer. Results were similar in subgroups, including persons who had never smoked and persons who reported very good to excellent health at baseline. Conclusions In this large prospective study, coffee consumption was inversely associated with total and cause-specific mortality. Whether this was a causal or associational finding cannot be determined from our data. (Funded by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics.) |
nfcorpus-qrel-MED-1645 | Generate text that best answers this question: Olive Oil and Artery Function | The acute effect of green tea consumption on endothelial function in healthy individuals.
BACKGROUND: Tea consumption is associated with decreased cardiovascular risk. Flow-mediated dilatation (FMD) of the brachial artery is related to coronary endothelial function and it is an independent predictor of cardiovascular risk. Black tea has a beneficial effect on endothelial function; the effect, however, of green tea on brachial artery reactivity has not been defined yet. DESIGN AND METHODS: We studied 14 healthy individuals (age 30+/-3 years) with no cardiovascular risk factors except from smoking (50%) on three separate occasions on which they took: (a) 6 g of green tea, (b) 125 mg of caffeine (the amount contained in 6 g of tea), or (c) hot water. FMD of the brachial artery was measured before each intervention and 30, 90, and 120 min afterward. High-sensitivity C-reactive protein, interleukins 6 (Il-6) and 1b (Il-1b), total plasma antioxidative capacity, and total plasma oxidative status/stress were measured at baseline and at 120 min after each intervention. RESULTS: Resting and hyperemic brachial artery diameter did not change either with tea or with caffeine. FMD increased significantly with tea (by 3.69%, peak at 30 min, P<0.02), whereas it did not change significantly with caffeine (increase by 1.72%, peak at 30 min, P=NS). Neither tea nor caffeine had any effect on high-sensitivity C-reactive protein, Il-6, Il-1b, total plasma antioxidative capacity, or total plasma oxidative status/stress. CONCLUSION: Green tea consumption has an acute beneficial effect on endothelial function, assessed with FMD of the brachial artery, in healthy individuals. This may be involved in the beneficial effect of tea on cardiovascular risk. |
nfcorpus-qrel-MED-1646 | Generate text that best answers this question: Olive Oil and Artery Function | A new proposed guidance system for beverage consumption in the United States.
The Beverage Guidance Panel was assembled to provide guidance on the relative health and nutritional benefits and risks of various beverage categories. The beverage panel was initiated by the first author. The Panel's purpose is to attempt to systematically review the literature on beverages and health and provide guidance to the consumer. An additional purpose of the Panel is to develop a deeper dialog among the scientific community on overall beverage consumption patterns in the United States and on the great potential to change this pattern as a way to improve health. Over the past several decades, levels of overweight and obesity have increased across all population groups in the United States. Concurrently, an increased daily intake of 150-300 kcal (for different age-sex groups) has occurred, with approximately 50% of the increased calories coming from the consumption of calorically sweetened beverages. The panel ranked beverages from the lowest to the highest value based on caloric and nutrient contents and related health benefits and risks. Drinking water was ranked as the preferred beverage to fulfill daily water needs and was followed in decreasing value by tea and coffee, low-fat (1.5% or 1%) and skim (nonfat) milk and soy beverages, noncalorically sweetened beverages, beverages with some nutritional benefits (fruit and vegetable juices, whole milk, alcohol, and sports drinks), and calorically sweetened, nutrient-poor beverages. The Panel recommends that the consumption of beverages with no or few calories should take precedence over the consumption of beverages with more calories. |
nfcorpus-qrel-MED-1647 | Generate text that best answers this question: Olive Oil and Artery Function | Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease.
BACKGROUND: Epidemiological studies suggest that tea consumption decreases cardiovascular risk, but the mechanisms of benefit remain undefined. Endothelial dysfunction has been associated with coronary artery disease and increased oxidative stress. Some antioxidants have been shown to reverse endothelial dysfunction, and tea contains antioxidant flavonoids. Methods and Results-- To test the hypothesis that tea consumption will reverse endothelial dysfunction, we randomized 66 patients with proven coronary artery disease to consume black tea and water in a crossover design. Short-term effects were examined 2 hours after consumption of 450 mL tea or water. Long-term effects were examined after consumption of 900 mL tea or water daily for 4 weeks. Vasomotor function of the brachial artery was examined at baseline and after each intervention with vascular ultrasound. Fifty patients completed the protocol and had technically suitable ultrasound measurements. Both short- and long-term tea consumption improved endothelium- dependent flow-mediated dilation of the brachial artery, whereas consumption of water had no effect (P<0.001 by repeated-measures ANOVA). Tea consumption had no effect on endothelium-independent nitroglycerin-induced dilation. An equivalent oral dose of caffeine (200 mg) had no short-term effect on flow-mediated dilation. Plasma flavonoids increased after short- and long-term tea consumption. CONCLUSIONS: Short- and long-term black tea consumption reverses endothelial vasomotor dysfunction in patients with coronary artery disease. This finding may partly explain the association between tea intake and decreased cardiovascular disease events. |
nfcorpus-qrel-MED-1648 | Generate text that best answers this question: Olive Oil and Artery Function | Coffee and endothelial function: a battle between caffeine and antioxidants?
Although coffee is largely consumed by adults in Western countries, controversy exists about its impact on the cardiovascular system. We recently demonstrated that caffeinated and decaffeinated espresso coffee have different acute effects on endothelial function in healthy subjects, measured using flow-mediated dilation (FMD) of the brachial artery. In this study, we measured the anti-oxidant capacity of two coffee substances in terms of free stable radical 2,2-diphenyl-1-picryl-hydrazyl 50% inhibition (I(50) DPPH). The caffeinated coffee had a slightly higher anti-oxidant capacity than decaffeinated espresso coffee (I(50) DPPH: 1.13±0.02 vs 1.30±0.03 μl; P<0.001). We suggest that the unfavourable effects observed after caffeinated coffee ingestion are due to caffeine and that the antioxidant activity is responsible for the increased FMD observed after decaffeinated coffee ingestion. Further clinical and epidemiological studies are needed to understand the chronic effects of coffee consumption on health. |
nfcorpus-qrel-MED-1649 | Generate text that best answers this question: Olive Oil and Artery Function | Consumption of a boiled Greek type of coffee is associated with improved endothelial function: the Ikaria study.
OBJECTIVE: The association of coffee consumption with cardiovascular disease remains controversial. Endothelial function is associated with cardiovascular risk. We examined the association between chronic coffee consumption and endothelium function in elderly inhabitants of the island of Ikaria. METHODS: The analysis was conducted on 142 elderly subjects (aged 66-91 years) of the Ikaria Study. Endothelial function was evaluated by ultrasound measurement of flow-mediated dilation (FMD). Coffee consumption was evaluated based on a food frequency questionnaire and was categorized as 'low' (< 200 ml/day), 'moderate' (200-450 ml/day), or 'high' (> 450 ml/day). RESULTS: From the subjects included in the study, 87% consumed a boiled Greek type of coffee. Moreover, 40% had a 'low', 48% a 'moderate' and 13% a 'high' daily coffee consumption. There was a linear increase in FMD according to coffee consumption ('low': 4.33 ± 2.51% vs 'moderate': 5.39 ± 3.09% vs 'high': 6.47 ± 2.72%; p = 0.032). Moreover, subjects consuming mainly a boiled Greek type of coffee had a significantly higher FMD compared with those consuming other types of coffee beverages (p = 0.035). CONCLUSIONS: Chronic coffee consumption is associated with improved endothelial function in elderly subjects, providing a new connection between nutrition and vascular health. |
nfcorpus-qrel-MED-2222 | Generate text that best answers this question: Olive Oil and Artery Function | Effect of cocoa/chocolate ingestion on brachial artery flow-mediated dilation and its relevance to cardiovascular health and disease in humans.
Prospective studies indicate that high intake of dietary flavanols, such as those contained in cocoa/chocolate, are associated with reduced rates of cardiovascular-related morbidity and mortality in humans. Numerous mechanisms may underlie these associations such as favorable effects of flavanols on blood pressure, platelet aggregation, thrombosis, inflammation, and the vascular endothelium. The brachial artery flow-mediated dilation (FMD) technique has emerged as a robust method to quantify endothelial function in humans. Collectively, the preponderance of evidence indicates that FMD is a powerful surrogate measure for firm cardiovascular endpoints, such as cardiovascular-related mortality, in humans. Thus, literally thousands of studies have utilized this technique to document group differences in FMD, as well as to assess the effects of various interventions on FMD. In regards to the latter, numerous studies indicate that both acute and chronic ingestion of cocoa/chocolate increases FMD in humans. Increases in FMD after cocoa/chocolate ingestion appear to be dose-dependent such that greater increases in FMD are observed after ingestion of larger quantities. The mechanisms underlying these responses are likely diverse, however most data suggest an effect of increased nitric oxide bioavailability. Thus, positive vascular effects of cocoa/chocolate on the endothelium may underlie (i.e., be linked mechanistically to) reductions in cardiovascular risk in humans. Copyright © 2012 Elsevier Inc. All rights reserved. |
nfcorpus-qrel-MED-2223 | Generate text that best answers this question: Olive Oil and Artery Function | Evaluation of Antiradical Activity of Different Cocoa and Chocolate Products: Relation with Lipid and Protein Composition
Chocolate antioxidant properties are often claimed; however, they are frequently different from the parent natural sources due to the industry or artisan transformation. In particular, antioxidant property of chocolate and cocoa are not adequately taken into consideration by consumers who normally make use of this food just for its flavor and taste properties. In this study, we have investigated the antioxidant capacity and total phenolic content of cocoa nibs, cocoa masses, and corresponding chocolate bars with different percentages of cocoa from different origins. The antioxidant capacity of the different samples was measured by two different assays [1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) and ferric reducing antioxidant of potency (FRAP) tests]. The Folin–Ciocalteu reagent was used to assess the total phenolic content. The masses showed a higher antioxidant power than the nibs, and this has been attributed to the fact that in the nibs is still present the lipid part, which will form the cocoa butter. The influence of milk, whey, and soy proteins was also investigated. Our results showed that the extra dark cocoa bar, 100% cocoa chocolate, is the best in terms of total polyphenol content and in terms of antioxidant capacity according to the DPPH and FRAP tests. In addition, the bars of organic dark chocolate 80%, dark Tanzania 80%, and Trinidad 80% products are well performing in all respects. As highlighted by us, the antiradical properties of cocoa products are higher than many antioxidant supplements in tablets. |
nfcorpus-qrel-MED-2224 | Generate text that best answers this question: Olive Oil and Artery Function | Dark chocolate improves coronary vasomotion and reduces platelet reactivity.
BACKGROUND: Dark chocolate has potent antioxidant properties. Coronary atherosclerosis is promoted by impaired endothelial function and increased platelet activation. Traditional risk factors, high oxidative stress, and reduced antioxidant defenses play a crucial role in the pathogenesis of atherosclerosis, particularly in transplanted hearts. Thus, flavonoid-rich dark chocolate holds the potential to have a beneficial impact on graft atherosclerosis. METHODS AND RESULTS: We assessed the effect of flavonoid-rich dark chocolate compared with cocoa-free control chocolate on coronary vascular and platelet function in 22 heart transplant recipients in a double-blind, randomized study. Coronary vasomotion was assessed with quantitative coronary angiography and cold pressor testing before and 2 hours after ingestion of 40 g of dark (70% cocoa) chocolate or control chocolate, respectively. Two hours after ingestion of flavonoid-rich dark chocolate, coronary artery diameter was increased significantly (from 2.36+/-0.51 to 2.51+/-0.59 mm, P<0.01), whereas it remained unchanged after control chocolate. Endothelium-dependent coronary vasomotion improved significantly after dark chocolate (4.5+/-11.4% versus -4.3+/-11.7% in the placebo group, P=0.01). Platelet adhesion decreased from 4.9+/-1.1% to 3.8+/-0.8% (P=0.04) in the dark chocolate group but remained unchanged in the control group. CONCLUSIONS: Dark chocolate induces coronary vasodilation, improves coronary vascular function, and decreases platelet adhesion 2 hours after consumption. These immediate beneficial effects were paralleled by a significant reduction of serum oxidative stress and were positively correlated with changes in serum epicatechin concentration. |
nfcorpus-qrel-MED-2225 | Generate text that best answers this question: Olive Oil and Artery Function | Effect of dark chocolate on renal tissue oxygenation as measured by BOLD-MRI in healthy volunteers.
BACKGROUND: Cocoa is rich in flavonoids, has anti-oxidative properties and increases the bioavailability of nitric oxide (NO). Adequate renal tissue oxygenation is crucial for the maintenance of renal function. The goal of this study was to investigate the effect of cocoa-rich dark chocolate (DC) on renal tissue oxygenation in humans, as compared to flavonoid-poor white chocolate (WC). METHODS: Ten healthy volunteers with preserved kidney function (mean age ± SD 35 ± 12 years, 70% women, BMI 21 ± 3 kg/m2) underwent blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) before and 2 hours after the ingestion of 1 g/kg of DC (70% cocoa). Renal tissue oxygenation was determined by the measurement of R2* maps on 4 coronal slices covering both kidneys. The mean R2* (= 1/T2*) values in the medulla and cortex were calculated, a low R2* indicating high tissue oxygenation. Eight participants also underwent BOLD-MRI at least 1 week later, before and 2 hours after the intake of 1 g/kg WC. RESULTS: The mean medullary R2* was lower after DC intake compared to baseline (28.2 ± 1.3 s-1 vs. 29.6 ± 1.3 s-1, p = 0.04), whereas cortical and medullary R2* values did not change after WC intake. The change in medullary R2* correlated with the level of circulating (epi)catechines, metabolites of flavonoids (r = 0.74, p = 0.037), and was independent of plasma renin activity. CONCLUSION: This study suggests for the first time an increase of renal medullary oxygenation after intake of dark chocolate. Whether this is linked to flavonoid-induced changes in renal perfusion or oxygen consumption, and whether cocoa has potentially renoprotective properties, merits further study. |
nfcorpus-qrel-MED-2226 | Generate text that best answers this question: Olive Oil and Artery Function | Effects of sugar-sweetened and sugar-free cocoa on endothelial function in overweight adults.
BACKGROUND: Studies of cocoa suggest an array of cardiovascular benefits; however, the effects of daily intake of sugar-free and sugar-sweetened cocoa beverages on endothelial function (EF) have yet to be established. METHODS: 44 adults (BMI 25-35 kg/m2) participated in a randomized, controlled, crossover trial. Participants were randomly assigned to a treatment sequence: sugar-free cocoa beverage, sugar-sweetened cocoa beverage, and sugar-sweetened cocoa-free placebo. Treatments were administered daily for 6 weeks, with a 4-week washout period. RESULTS: Cocoa ingestion improved EF measured as flow-mediated dilation (FMD) compared to placebo (sugar-free cocoa: change, 2.4% [95% CI, 1.5 to 3.2] vs. -0.8% [95% CI, -1.9 to 0.3]; difference, 3.2% [95% CI, 1.8 to 4.6]; p<0.001 and sugar-sweetened cocoa: change, 1.5% [95% CI, 0.6 to 2.4] vs. -0.8% [95% CI, -1.9 to 0.3]; difference, 2.3% [95% CI, 0.9 to 3.7]; p=0.002). The magnitude of improvement in FMD after consumption of sugar-free versus sugar-sweetened cocoa was greater, but not significantly. Other biomarkers of cardiac risk did not change appreciably from baseline. BMI remained stable throughout the study. CONCLUSIONS: Daily cocoa ingestion improves EF independently of other biomarkers of cardiac risk, and does not cause weight gain. Sugar-free preparations may further augment endothelial function. Copyright © 2009 Elsevier Ireland Ltd. All rights reserved. |
nfcorpus-qrel-MED-2227 | Generate text that best answers this question: Olive Oil and Artery Function | Chocolate--guilty pleasure or healthy supplement?
Dark chocolate and other cocoa products are popular in the population as a whole, but their overall health benefit remains controversial. Observations from the Kuna Indian population have shown an impressive cardiovascular health benefit from cocoa. For various reasons, this benefit has not been as robust as in other populations. Additionally, several mechanisms have been proposed that might confer cocoa's possible health benefit, but no consensus has been reached on cocoa's physiologic role in promoting cardiovascular health. Flavanols, as well as theobromine, may contribute to enhancements in endothelial function and subsequent improvements in various contributors to cardiovascular disease (CVD) including hypertension, platelet aggregation and adhesion, insulin resistance, and hypercholesterolemia. While the benefits of cocoa may be altered at the various stages of growth, development, and production, it appears that for many people "healthy" dark chocolate may, indeed, provide a pleasurable role in CVD risk reduction. The objectives of this review are to discuss the associations of cocoa with decreased blood pressure and improved CVD risk, to describe the possible mechanisms for these potential benefits, and to highlight considerations for the use of cocoa as a dietary supplement. |
nfcorpus-qrel-MED-2228 | Generate text that best answers this question: Olive Oil and Artery Function | Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials.
BACKGROUND: There is substantial interest in chocolate and flavan-3-ols for the prevention of cardiovascular disease (CVD). OBJECTIVE: The objective was to systematically review the effects of chocolate, cocoa, and flavan-3-ols on major CVD risk factors. DESIGN: We searched Medline, EMBASE, and Cochrane databases for randomized controlled trials (RCTs) of chocolate, cocoa, or flavan-3-ols. We contacted authors for additional data and conducted duplicate assessment of study inclusion, data extraction, validity, and random-effects meta-analyses. RESULTS: We included 42 acute or short-term chronic (≤18 wk) RCTs that comprised 1297 participants. Insulin resistance (HOMA-IR: -0.67; 95% CI: -0.98, -0.36) was improved by chocolate or cocoa due to significant reductions in serum insulin. Flow-mediated dilatation (FMD) improved after chronic (1.34%; 95% CI: 1.00%, 1.68%) and acute (3.19%; 95% CI: 2.04%, 4.33%) intakes. Effects on HOMA-IR and FMD remained stable to sensitivity analyses. We observed reductions in diastolic blood pressure (BP; -1.60 mm Hg; 95% CI: -2.77, -0.43 mm Hg) and mean arterial pressure (-1.64 mm Hg; 95% CI: -3.27, -0.01 mm Hg) and marginally significant effects on LDL (-0.07 mmol/L; 95% CI: -0.13, 0.00 mmol/L) and HDL (0.03 mmol/L; 95% CI: 0.00, 0.06 mmol/L) cholesterol. Chocolate or cocoa improved FMD regardless of the dose consumed, whereas doses >50 mg epicatechin/d resulted in greater effects on systolic and diastolic BP. GRADE (Grading of Recommendations, Assessment, Development and Evaluation, a tool to assess quality of evidence and strength of recommendations) suggested low- to moderate-quality evidence of beneficial effects, with no suggestion of negative effects. The strength of evidence was lowered due to unclear reporting for allocation concealment, dropouts, missing data on outcomes, and heterogeneity in biomarker results in some studies. CONCLUSIONS: We found consistent acute and chronic benefits of chocolate or cocoa on FMD and previously unreported promising effects on insulin and HOMA-IR. Larger, longer-duration, and independently funded trials are required to confirm the potential cardiovascular benefits of cocoa flavan-3-ols. |
nfcorpus-qrel-MED-2370 | Generate text that best answers this question: Olive Oil and Artery Function | Thematic review series: the pathogenesis of atherosclerosis: an interpretive history of the cholesterol controversy, part III: mechanistically defi...
In this third installment of the series, we point out that the absence of an explicit, detailed and plausible hypothesis linking hypercholesterolemia to the events in the artery wall was probably an important reason for continuing skepticism and for failure to treat elevated blood cholesterol levels. The rapid advances in understanding of lipoprotein metabolism in the 1950s and 1960s and the application of modern cellular biology in the 1970s provided the context for a modern consensus on pathogenetic mechanisms of atherogenesis. |
nfcorpus-qrel-MED-2371 | Generate text that best answers this question: Olive Oil and Artery Function | Daily egg consumption in hyperlipidemic adults - Effects on endothelial function and cardiovascular risk
Background Limiting consumption of eggs, which are high in cholesterol, is generally recommended to reduce risk of cardiovascular disease. However, recent evidence suggests that dietary cholesterol has limited influence on serum cholesterol or cardiac risk. Objective To assess the effects of egg consumption on endothelial function and serum lipids in hyperlipidemic adults. Methods Randomized, placebo-controlled crossover trial of 40 hyperlipidemic adults (24 women, 16 men; average age = 59.9 ± 9.6 years; weight = 76.3 ± 21.8 kilograms; total cholesterol = 244 ± 24 mg/dL). In the acute phase, participants were randomly assigned to one of the two sequences of a single dose of three medium hardboiled eggs and a sausage/cheese breakfast sandwich. In the sustained phase, participants were then randomly assigned to one of the two sequences of two medium hardboiled eggs and 1/2 cup of egg substitute daily for six weeks. Each treatment assignment was separated by a four-week washout period. Outcome measures of interest were endothelial function measured as flow mediated dilatation (FMD) and lipid panel. Results Single dose egg consumption had no effects on endothelial function as compared to sausage/cheese (0.4 ± 1.9 vs. 0.4 ± 2.4%; p = 0.99). Daily consumption of egg substitute for 6 weeks significantly improved endothelial function as compared to egg (1.0 ± 1.2% vs. -0.1 ± 1.5%; p < 0.01) and lowered serum total cholesterol (-18 ± 18 vs. -5 ± 21 mg/dL; p < 0.01) and LDL (-14 ± 20 vs. -2 ± 19 mg/dL; p = 0.01). Study results (positive or negative) are expressed in terms of change relative to baseline. Conclusions Egg consumption was found to be non-detrimental to endothelial function and serum lipids in hyperlipidemic adults, while egg substitute consumption was beneficial. |
nfcorpus-qrel-MED-2372 | Generate text that best answers this question: Olive Oil and Artery Function | Egg consumption and endothelial function: a randomized controlled crossover trial.
BACKGROUND: Because of egg cholesterol content, reduction in egg consumption is generally recommended to reduce risk of cardiovascular disease. Recently, however, evidence has been accumulating to suggest that dietary cholesterol is less relevant to cardiovascular risk than dietary saturated fat. This randomized controlled crossover trial was conducted to determine the effects of egg ingestion on endothelial function, a reliable index of cardiovascular risk. METHODS: Forty-nine healthy adults (mean age 56 years, 40% females) underwent a baseline brachial artery reactivity study (BARS), and were assigned to two eggs or oats daily for 6 weeks in random sequence with a 4-week washout. A BARS was done at the end of each treatment phase, measuring flow-mediated vasodilation (FMD) in the brachial artery using a high-frequency ultrasound. RESULTS: FMD was stable in both egg and oat groups, and between-treatment differences were not significant (egg -0.96%, oatmeal -0.79%; p value >0.05). Six weeks of egg ingestion had no effect on total cholesterol (baseline: 203.8 mg/dl; post-treatment: 205.3) or LDL (baseline: 124.8 mg/dl; post-treatment: 129.1). In contrast, 6 weeks of oats lowered total cholesterol (to 194 mg/dl; p = 0.0017) and LDL (to 116.6 mg/dl; p = 0.012). There were no differences in body mass index (BMI), triglyceride, HDL or SBP levels between egg and oat treatment assignments. CONCLUSION: Short-term egg consumption does not adversely affect endothelial function in healthy adults, supporting the view that dietary cholesterol may be less detrimental to cardiovascular health than previously thought. |
nfcorpus-qrel-MED-4324 | Generate text that best answers this question: Olive Oil and Artery Function | Egg yolk consumption and carotid plaque.
BACKGROUND: Increasingly the potential harm from high cholesterol intake, and specifically from egg yolks, is considered insignificant. We therefore assessed total plaque area (TPA) in patients attending Canadian vascular prevention clinics to determine if the atherosclerosis burden, as a marker of arterial damage, was related to egg intake. To provide perspective on the magnitude of the effect, we also analysed the effect of smoking (pack-years). METHODS: Consecutive patients attending vascular prevention clinics at University Hospital had baseline measurement of TPA by duplex ultrasound, and filled out questionnaires regarding their lifestyle and medications, including pack-years of smoking, and the number of egg yolks consumed per week times the number of years consumed (egg-yolk years). RESULTS: Data were available in 1262 patients; mean (SD) age was 61.5 (14.8) years; 47% were women. Carotid plaque area increased linearly with age after age 40, but increased exponentially with pack-years of smoking and with egg-yolk years. Plaque area in patients consuming <2 eggs per week (n = 388) was 125 ± 129 mm(2), versus 132 ± 142 mm(2) in those consuming 3 or more eggs per week (n = 603); (p < 0.0001 after adjustment for age). In multiple regression, egg-yolk years remained significant after adjusting for coronary risk factors. INTERPRETATION: Our findings suggest that regular consumption of egg yolk should be avoided by persons at risk of cardiovascular disease. This hypothesis should be tested in a prospective study with more detailed information about diet, and other possible confounders such as exercise and waist circumference. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
nfcorpus-qrel-MED-2376 | Generate text that best answers this question: Olive Oil and Artery Function | Usefulness of brachial artery flow-mediated dilation to predict long-term cardiovascular events in subjects without heart disease.
Endothelial dysfunction is considered an important prognostic factor in atherosclerosis. To determine the long-term association of brachial artery flow-mediated dilation (FMD) and adverse cardiovascular (CV) events in healthy subjects, we prospectively assessed brachial FMD in 618 consecutive healthy subjects with no apparent heart disease, 387 men (63%), and mean age 54 ± 11 years. After overnight fasting and discontinuation of all medications for ≥12 hours, FMD was assessed using high-resolution linear array ultrasound. Subjects were divided into 2 groups: FMD ≤11.3% (n = 309) and >11.3% (n = 309), where 11.3% is the median FMD, and were comparable regarding CV risk factors, lipoproteins, fasting glucose, C-reactive protein, concomitant medications, and Framingham 10-year risk score. In a mean clinical follow-up of 4.6 ± 1.8 years, the composite CV events (all-cause mortality, nonfatal myocardial infarction, hospitalization for heart failure or angina pectoris, stroke, coronary artery bypass grafting, and percutaneous coronary interventions) were significantly more common in subjects with FMD ≤11.3% rather than >11.3% (15.2% vs 1.2%, p = 0.0001, respectively). Univariate analysis demonstrated that the median FMD significantly predicted CV events (odds ratio 2.78, 95% CI 1.35 to 5.71, p <0.001). Multivariate analysis, controlling for traditional CV risk factors, demonstrated that median FMD was the best independent predictor of long-term CV adverse events (odds ratio 2.93, 95% CI 1.28 to 6.68, p <0.001). In conclusion, brachial artery median FMD independently predicts long-term adverse CV events in healthy subjects with no apparent heart disease in addition to those derived from traditional risk factor assessment. Copyright © 2014 Elsevier Inc. All rights reserved. |
nfcorpus-qrel-MED-2593 | Generate text that best answers this question: Olive Oil and Artery Function | Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial
Background Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person. Methods We evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED (‘PREvención con DIeta MEDiterránea’) study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality. Results During a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend <0.05, all). Compared to non-consumers, subjects consuming nuts >3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts >3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66). Conclusions Increased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk. Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165. Trial registration Clinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005. |
nfcorpus-qrel-MED-2378 | Generate text that best answers this question: Olive Oil and Artery Function | Effects of Diets High in Walnuts and Flax Oil on Hemodynamic Responses to Stress and Vascular Endothelial Function
Background Polyunsaturated fatty acids (PUFA) have beneficial effects on cardiovascular risk, although the mechanisms are incompletely understood. In a previous article, we showed significant reductions in low-density lipoprotein cholesterol and several markers of inflammation with increasing intake of alpha-linolenic acid (ALA) from walnuts and flax. Objective To examine effects of ALA on cardiovascular responses to acute stress, flow-mediated dilation (FMD) of the brachial artery, and blood concentrations of endothelin-1 and arginine-vasopressin (AVP). Design Using a randomized, crossover study design, cardiovascular responses to acute stress were assessed in 20 hypercholesterolemic subjects, a subset of whom also underwent FMD testing (n = 12). Participants were fed an average American diet (AAD) and 2 experimental diets that varied in the amount of ALA and linoleic acid (LA) that they contained. The AAD provided 8.7% energy from PUFA (7.7% LA, 0.8% ALA). On the LA diet, saturated fat was reduced, and PUFA from walnuts and walnut oil provided 16.4% of energy (12.6% LA, 3.6% ALA). On the ALA diet, walnuts, walnut oil, and flax oil provided 17% energy from PUFA (10.5% LA, 6.5% ALA). Results The ALA and LA diets significantly reduced diastolic blood pressure (−2 to −3 mm Hg) and total peripheral resistance (−4%), and this effect was evident at rest and during stress (main effect of diet, p < 0.02). FMD increased (+34%) on the diet containing additional ALA. AVP also increased by 20%, and endothelin-1 was unchanged. Conclusions These results suggest novel mechanisms for the cardioprotective effects of walnuts and flax, and further work is needed to identify the bioactives responsible for these effects. |
nfcorpus-qrel-MED-2379 | Generate text that best answers this question: Olive Oil and Artery Function | Effects of Walnuts on Endothelial Function in Overweight Adults with Visceral Obesity: A Randomized, Controlled, Crossover Trial
Objectives Metabolic syndrome is a precursor of diabetes and cardiovascular disease (CVD). Walnut ingestion has been shown to reduce CVD risk indices in diabetes. This randomized controlled crossover trial was performed to investigate the effects of daily walnut consumption on endothelial function and other biomarkers of cardiac risk in a population of overweight individuals with visceral adiposity. Methods Forty-six overweight adults (average age, 57.4 years; 28 women, 18 men) with elevated waist circumference and 1 or more additional signs of metabolic syndrome were randomly assigned to two 8-week sequences of walnut-enriched ad libitum diet and ad libitum diet without walnuts, which were separated by a 4-week washout period. The primary outcome measure was the change in flow-mediated vasodilation (FMD) of the brachial artery. Secondary measures included serum lipid panel, fasting glucose and insulin, Homeostasis Model Assessment–Insulin Resistance values, blood pressure, and anthropometric measures. Results FMD improved significantly from baseline when subjects consumed a walnut-enriched diet as compared with the control diet (1.4% ± 2.4% versus 0.3% ± 1.5%; p = 0.019). Beneficial trends in systolic blood pressure reduction were seen, and maintenance of the baseline anthropometric values was also observed. Other measures were unaltered. Conclusion Daily ingestion of 56 g of walnuts improves endothelial function in overweight adults with visceral adiposity. The addition of walnuts to the diet does not lead to weight gain. Further study of the potential role of walnut intake in diabetes and CVD prevention is warranted. |
nfcorpus-qrel-MED-2380 | Generate text that best answers this question: Olive Oil and Artery Function | Nuts, hypertension and endothelial function.
BACKGROUND AND AIMS: High blood pressure (BP) is considered a major risk factor for cardiovascular disease. Among lifestyle factors, diet plays a key role in the prevention and control of high BP. Therefore, it is important to elucidate which dietary components can exert beneficial effects on BP through modulation of endothelial function (EF) or by other mechanisms. In this paper we review the role of nutrients, foods, particularly nuts, and dietary patterns on BP control. DATA SYNTHESIS: Because nuts are low in sodium and contain significant amounts of mono- and polyunsaturated fatty acids, fiber, minerals such as magnesium, potassium and calcium, and antioxidants, they have been suggested as potentially protective foods against hypertension. Limited evidence from prospective studies and clinical trials suggests that nut consumption has a beneficial effect on both BP and EF. However, BP changes were a secondary outcome in nut feeding trials and no study used ambulatory BP monitoring as the standard for BP measurements. CONCLUSIONS: Further clinical trials, ideally using ambulatory BP monitoring, are needed to establish the potential protective effect of nut consumption on hypertension and vascular reactivity. Copyright © 2011 Elsevier B.V. All rights reserved. |
nfcorpus-qrel-MED-2381 | Generate text that best answers this question: Olive Oil and Artery Function | A systematic review of the effects of nuts on blood lipid profiles in humans.
The inverse association of nut consumption and risk markers of coronary heart disease (lipids) has sparked the interest of the scientific and lay community. The objective of this study was to conduct a systematic review to investigate the effects of nuts on the lipid profile. Medline and Web of Science databases were searched from the start of the database to August 2004 and supplemented by cross-checking reference lists of relevant publications. Human intervention trials with the objective of investigating independent effects of nuts on lipid concentrations were included. From the literature search, 415 publications were screened and 23 studies were included. These papers received a rating based upon the methodology as it appeared in the publication. No formal statistical analysis was performed due to the large differences in study designs of the dietary intervention trials. The results of 3 almond (50-100 g/d), 2 peanut (35-68 g/d), 1 pecan nut (72 g/d), and 4 walnut (40-84 g/d) studies showed decreases in total cholesterol between 2 and 16% and LDL cholesterol between 2 and 19% compared with subjects consuming control diets. Consumption of macadamia nuts (50-100 g/d) produced less convincing results. In conclusion, consumption of approximately 50-100 g (approximately 1.5-3.5 servings) of nuts > or = 5 times/wk as part of a heart-healthy diet with total fat content (high in mono- and/or polyunsaturated fatty acids) of approximately 35% of energy may significantly decrease total cholesterol and LDL cholesterol in normo- and hyperlipidemic individuals. |
nfcorpus-qrel-MED-2382 | Generate text that best answers this question: Olive Oil and Artery Function | US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up.
BACKGROUND: Allergy to peanuts and tree nuts (TNs) is the leading cause of fatal allergic reactions in the United States, and the prevalence appears to be increasing. OBJECTIVES: We sought to determine the US prevalence of self-reported peanut, TN, and sesame allergy in 2008 and compare results with comparable surveys conducted in 1997 and 2002. METHODS: A nationwide, cross-sectional, random telephone survey for peanut and TN allergy was conducted with a previously used questionnaire, with additional questions about sesame. RESULTS: A total of 5,300 households (13,534 subjects) were surveyed (participation rate, 42% vs 52% in 2002 and 67% in 1997). Peanut allergy, TN allergy, or both was reported by 1.4% of subjects (95% CI, 1.2% to 1.6%) compared with 1.2% in 2002 and 1.4% in 1997. For adults, the prevalence was 1.3% (95% CI, 1.1% to 1.6%), which was not significantly different from prior surveys. However, the prevalence of peanut or TN allergy for children younger than 18 years was 2.1% (95% CI, 1.6% to 2.7%) compared with 1.2% in 2002 (P = .007) and 0.6% in 1997 (P < .001). The prevalence of peanut allergy in children in 2008 was 1.4% (95% CI, 1.0% to 1.9%) compared with 0.8% in 2002 (P = not significant) and 0.4% in 1997 (P < .0001). The prevalence of childhood TN allergy increased significantly across the survey waves (1.1% in 2008, 0.5% in 2002, and 0.2% in 1997). Sesame allergy was reported by 0.1% (95% CI, 0.0% to 0.2%). CONCLUSIONS: Although caution is required in comparing surveys, peanut allergy, TN allergy, or both continue to be reported by more than 1% of the US population (eg, >3 million subjects) and appear to be increasingly reported among children over the past decade. Sesame allergy is reported much less commonly. Copyright (c) 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
nfcorpus-qrel-MED-2383 | Generate text that best answers this question: Olive Oil and Artery Function | The role of nuts in the optimal diet: time for a critical appraisal?
During the last decades, nuts have attracted the attention of researchers for their potential benefits in cardiovascular prevention. We discuss here some aspects of the assumed beneficial effects of nuts, weighing them against potential harm. Epidemiological observations and controlled intervention trials consistently suggest that nuts consumption is associated with improved serum lipid profile, thus helping decrease cardiovascular risk. Being nuts an energy dense food, their impact on energy balance and body weight should be considered. In particular, the claim that adding nuts to the habitual diet, thus increasing calorie intake, does not cause body fat accumulation still needs evidence and biological plausibility. The potential risk associated with the relatively frequent occurrence of allergic reactions following the consumption of nuts is also discussed. Copyright © 2012 Elsevier Ltd. All rights reserved. |
nfcorpus-qrel-MED-2384 | Generate text that best answers this question: Olive Oil and Artery Function | Hazelnut-enriched diet improves cardiovascular risk biomarkers beyond a lipid-lowering effect in hypercholesterolemic subjects.
BACKGROUND: Tree nuts, particularly almonds, walnuts, and pistachios, have been shown to possess cardioprotective effects. However, there is little information on the effects of hazelnut consumption on cardiovascular risk markers. METHODS: The antiatherogenic effect of hazelnut before and after consumption in hypercholesterolemic subjects was investigated. Twenty-one hypercholesterolemic volunteers (18 men and 3 women) were recruited in a double control sandwich model intervention study with a single group and three isoenergetic diet periods. These were control diet I (4 weeks), hazelnut-enriched diet (4 weeks; hazelnut contributing 18%-20% of the total daily energy intake), and control diet period II (4 weeks). The cardiovascular risk biomarkers such as endothelial function, using flow-mediated dilation (FMD) technique, low-density lipoprotein (LDL) oxidation products and inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP), soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1 (sVCAM-1) as well as lipids and lipoprotein levels were monitored. RESULTS: Consumption of a hazelnut-enriched diet significantly improved FMD (56.6%), total cholesterol (-7.8%), triacylglycerol (-7.3%), LDL-cholesterol (-6.17%), and high-density lipoprotein cholesterol (6.07%) compared with the control diet I. Oxidized-LDL, hs-CRP, and sVCAM-1 levels were significantly lower in the group ingesting a hazelnut-enriched diet compared with the control diets I and II. Modest correlations between sVCAM-1 and FMD and between sVCAM-1 and hs-CRP were observed (r = -0.49, P < .025; r = 0.66, P < .001, respectively). CONCLUSION: Hazelnut-enriched diets may exert antiatherogenic effect by improving endothelial function, preventing LDL oxidation, and inflammatory markers, in addition to their lipid and lipoprotein-lowering effects. These beneficial effects appeared to be reversible after 4 weeks on a hazelnut-free diet. Therefore, hazelnut may be incorporated into daily diet without change in total caloric intake for sustained health benefit. Copyright © 2013 National Lipid Association. All rights reserved. |
nfcorpus-qrel-MED-4249 | Generate text that best answers this question: Olive Oil and Artery Function | Crossover study of diets enriched with virgin olive oil, walnuts or almonds. Effects on lipids and other cardiovascular risk markers.
BACKGROUND AND AIMS: Virgin olive oil (VOO) and nuts are basic components of the Mediterranean diet, a heart-healthy dietary pattern. Nuts have well known cholesterol lowering effects, while evidence is unclear for VOO. We designed a study in hypercholesterolemic patients to assess the effects on serum lipids and other intermediate markers of cardiovascular risk of replacing 40% of the fat in the background diet with VOO, walnuts or almonds. METHODS AND RESULTS: After a 4 week run-in period with a healthy diet, eligible candidates were randomized into three diet sequences in a crossover design, with a common background diet enriched with VOO, walnuts or almonds, lasting 4 weeks each. Outcomes were changes of serum lipids and oxidation and inflammation markers, measured by standard methods. Plasma fatty acids were determined by gas chromatography to assess compliance. In 18 participants completing the study (9 women, mean age 56 y, BMI 25.7 kg/m(2)), LDL-cholesterol was reduced from baseline by 7.3%, 10.8% and 13.4% after the VOO, walnut and almond diets, respectively (P = 0.001, Friedman test). Total cholesterol and LDL/HDL ratios decreased in parallel. LDL-cholesterol decreases were greater than predicted from dietary fatty acid and cholesterol exchanges among diets. No changes of other lipid fractions, oxidation analytes or inflammatory biomarkers were observed. Plasma fatty acid changes after each diet sequence supported good compliance. CONCLUSION: The results confirm the cholesterol lowering properties of nut-enriched diets. They also suggest that phenolic-rich VOO has a cholesterol lowering effect independently of its fatty acid content, which clearly deserves further study. Copyright © 2010 Elsevier B.V. All rights reserved. |
nfcorpus-qrel-MED-5343 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Managing medical mistakes: ideology, insularity and accountability among internists-in-training.
By the end of graduate medical training, novice internists (collectively known as the housestaff) were initiated into the experience of either having done something to a patient which had a deleterious consequence or else having witnessed colleagues do the same. When these events occurred, the housestaff engaged in social-psychological processes, utilizing a variety of coping mechanisms and in-group practices to manage these mishaps. Three major mechanisms were utilized by the housestaff for defining and defending the various mishaps which frequently occurred: denial, discounting and distancing. Denial consisted of three components: the negation of the concept of error by defining the practice of medicine as an art with 'gray areas', the repression of actual mistakes by forgetting them and the redefinition of mistakes to non-mistakes. Discounting included those defenses which externalized the blame; namely mistakes which were due to circumstances beyond their control. These included: blaming the bureaucratic system outside of medicine; blaming superiors or subordinates within internal medicine; blaming the disease and blaming the patient. When they could not longer deny or discount a mistake because of its magnitude, they utilized distancing techniques. Not withstanding this shared elaborate repertoire of denial, discounting and distancing, it was found that profound doubts and even guilt remained for many housestaff. These troublesome feelings neither easily nor automatically resolved themselves. Interspersed among their defenses were fundamental questions of culpability and responsibility as they vacillated between self and other blame. For many 'the case was never closed', even as they terminated formal training, a point neglected in the medical and sociological literature. Little in their 3 year graduate program allowed them to work through the attendant vulnerability and ambiguity accompanying the managing of mistakes. Hence, there were maladaptive aspects of the collectively acquired defense mechanisms. The whole system of accountability during graduate medical specialty training was found to be a variable, and at times, contradictory process. The housestaff ultimately sees itself as the sole arbiter of mistakes and their adjudication. Housestaffers come to feel that nobody can judge them or their decisions, least of all their patients. As they progress through training even internal accountability cohorts--the Department of Medicine, teaching faculty and peers--are discounted to varying degrees. They have developed a strong ideology justifying their jealously guarded autonomy.(ABSTRACT TRUNCATED AT 400 WORDS) |
nfcorpus-qrel-MED-5344 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Risk factors for myocardial infarction in women and men: insights from the INTERHEART study.
AIMS: Coronary heart disease (CHD) is a leading cause of death among men and women globally. Women develop CHD about 10 years later than men, yet the reasons for this are unclear. The purpose of this report is to determine if differences in risk factor distributions exist between women and men across various age categories to help explain why women develop acute MI later than men. METHODS AND RESULTS: We used the INTERHEART global case-control study including 27 098 participants from 52 countries, 6787 of whom were women. The median age of first acute MI was higher in women than men (65 vs. 56 years; P < 0.0001). Nine modifiable risk factors were associated with MI in women and men. Hypertension [2.95(2.66 -3.28) vs. 2.32(2.16-2.48)], diabetes [4.26(3.68-4.94) vs. 2.67(2.43-2.94), physical activity [0.48(0.41-0.57) vs. 0.77(0.71-0.83)], and moderate alcohol use [0.41(0.34-0.50) vs. 0.88(0.82-0.94)] were more strongly associated with MI among women than men. The association of abnormal lipids, current smoking, abdominal obesity, high risk diet, and psychosocial stress factors with MI was similar in women and men. Risk factors associations were generally stronger among younger individuals compared to older women and men. The population attributable risk (PAR) of all nine risk factors exceeded 94%, and was similar among women and men (96 vs. 93%). Men were significantly more likely to suffer a MI prior to 60 years of age than were women, however, after adjusting for levels of risk factors, the sex difference in the probability of MI cases occurring before the age of 60 years was reduced by more than 80%. CONCLUSION: Women experience their first acute MI on average 9 years later than men. Nine modifiable risk factors are significantly associated with acute MI in both men and women and explain greater than 90% of the PAR. The difference in age of first MI is largely explained by the higher risk factor levels at younger ages in men compared to women. |
nfcorpus-qrel-MED-5345 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Five years after To Err Is Human: what have we learned?
Five years ago, the Institute of Medicine (IOM) called for a national effort to make health care safe. Although progress since then has been slow, the IOM report truly "changed the conversation" to a focus on changing systems, stimulated a broad array of stakeholders to engage in patient safety, and motivated hospitals to adopt new safe practices. The pace of change is likely to accelerate, particularly in implementation of electronic health records, diffusion of safe practices, team training, and full disclosure to patients following injury. If directed toward hospitals that actually achieve high levels of safety, pay for performance could provide additional incentives. But improvement of the magnitude envisioned by the IOM requires a national commitment to strict, ambitious, quantitative, and well-tracked national goals. The Agency for Healthcare Research and Quality should bring together all stakeholders, including payers, to agree on a set of explicit and ambitious goals for patient safety to be reached by 2010. |
nfcorpus-qrel-MED-5346 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Resident duty-hour restrictions-who are we protecting?: AOA critical issues.
As advocated by Nasca, our teaching programs must nurture professionalism and the effacement of self interest that is the core of the practice of medicine and the profession. The evidence to date suggests that work-hour restrictions based solely on clock-defined time limits discourage, rather than promote, the professional behavior that we desire in tomorrow's physicians. Notwithstanding any issues related to duty hours or fitness for duty, a competency-based system of medical education is both desirable and necessary in the current environment of medical education. In the absence of evidence to suggest that duty-hour limits reduce medical errors and enhance patient safety, and until we have evolved to a competency-based system of resident education, a misguided and overzealous focus on limiting work hours should not be allowed to exert the unintended consequence of eroding the ethos of professionalism that we, and our patients, have come to expect of a physician. |
nfcorpus-qrel-MED-5347 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Effects of health care provider work hours and sleep deprivation on safety and performance.
BACKGROUND: There has been increasing interest in the impact of resident-physician and nurse work hours on patient safety. The evidence demonstrates that work schedules have a profound effect on providers' sleep and performance, as well as on their safety and that of their patients. Nurses working shifts greater than 12.5 hours are at significantly increased risk of experiencing decreased vigilance on the job, suffering an occupational injury, or making a medical error. Physicians-in-training working traditional > 24-hour on-call shifts are at greatly increased risk of experiencing an occupational sharps injury or a motor vehicle crash on the drive home from work and of making a serious or even fatal medical error. As compared to when working 16-hours shifts, on-call residents have twice as many attentional failures when working overnight and commit 36% more serious medical errors. They also report making 300% more fatigue-related medical errors that lead to a patient's death. CONCLUSION: The weight of evidence strongly suggests that extended-duration work shifts significantly increase fatigue and impair performance and safety. From the standpoint of both providers and patients, the hours routinely worked by health care providers in the United States are unsafe. To reduce the unacceptably high rate of preventable fatigue-related medical error and injuries among health care workers, the United States must establish and enforce safe work-hour limits. |
nfcorpus-qrel-MED-1487 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Patients' Expectations of Screening and Preventive Treatments
PURPOSE An informed decision to accept a health care intervention requires an understanding of its likely benefit. This study assessed participants' estimates of the benefit, as well as minimum acceptable benefit, of screening for breast and bowel cancer and medication to prevent hip fracture and cardiovascular disease. METHODS Three general practitioners sent questionnaires to all registered patients aged 50 to 70 years. Patients agreeing to participate in the study were asked to estimate the number of events (fractures or deaths) prevented in a group of 5,000 patients undergoing each intervention over a period of 10 years, and to indicate the minimum number of events avoided by the intervention that they considered justified its use. The proportions of participants that overestimated each intervention's benefit were calculated, and univariate and multivariable analyses of predictors of response were performed. RESULTS The participation rate was 36%: 977 patients were invited to participate in the study, and 354 returned a completed questionnaire. Participants overestimated the degree of benefit conferred by all interventions: 90% of participants overestimated the effect of breast cancer screening, 94% overestimated the effect of bowel cancer screening, 82% overestimated the effect of hip fracture preventive medication, and 69% overestimated the effect of preventive medication for cardiovascular disease. Estimates of minimum acceptable benefit were more conservative, but other than for cardiovascular disease mortality prevention, most respondents indicated a minimum benefit greater than these interventions achieve. A lower level of education was associated with higher estimates of minimum acceptable benefit for all interventions. CONCLUSION Patients overestimated the risk reduction achieved with 4 examples of screening and preventive medications. A lower level of education was associated with higher minimum benefit to justify intervention use. This tendency to overestimate benefits may affect patients' decisions to use such interventions, and practitioners should be aware of this tendency when discussing these interventions with patients. |
nfcorpus-qrel-MED-1482 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Does hand hygiene compliance among health care workers change when patients are in contact precaution rooms in ICUs?
BACKGROUND: Hand hygiene compliance rates among health care workers (HCW) rarely exceed 50%. Contact precautions are thought to increase HCWs' hand hygiene awareness. We sought to determine any differences in hand hygiene compliance rates for HCW between patients in contact precaution and those not in any isolation. METHODS: In a hospital's medical (MICU) and surgical (SICU) intensive care units, a trained observer directly observed hand hygiene by the type of room (contact precaution or noncontact precaution) and the type of HCW (nurse or doctor). RESULTS: The SICU had similar compliance rates (36/75 [50.7%] in contact precaution rooms vs 223/431 [51.7%] compliance in noncontact precaution rooms, P > .5); the MICU also had similar hand hygiene compliance rates (67/132 [45.1%] in contact precaution rooms vs 96/213 [50.8%] in noncontact precaution rooms, P > .10). Hand hygiene compliance rates stratified by HCW were similar with 1 exception. The MICU nurses had a higher rate of hand hygiene compliance in contact precaution rooms than in rooms with noncontact precautions (66.7% vs 51.6%, respectively). CONCLUSION: Compliance with hand hygiene among HCWs did not differ between contact precaution rooms and rooms with noncontact precautions with the exception of the nurses in the MICU. Published by Mosby, Inc. |
nfcorpus-qrel-MED-1483 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Empirical evaluation of very large treatment effects of medical interventions.
CONTEXT: Most medical interventions have modest effects, but occasionally some clinical trials may find very large effects for benefits or harms. OBJECTIVE: To evaluate the frequency and features of very large effects in medicine. DATA SOURCES: Cochrane Database of Systematic Reviews (CDSR, 2010, issue 7). STUDY SELECTION: We separated all binary-outcome CDSR forest plots with comparisons of interventions according to whether the first published trial, a subsequent trial (not the first), or no trial had a nominally statistically significant (P < .05) very large effect (odds ratio [OR], ≥5). We also sampled randomly 250 topics from each group for further in-depth evaluation. DATA EXTRACTION: We assessed the types of treatments and outcomes in trials with very large effects, examined how often large-effect trials were followed up by other trials on the same topic, and how these effects compared against the effects of the respective meta-analyses. RESULTS: Among 85,002 forest plots (from 3082 reviews), 8239 (9.7%) had a significant very large effect in the first published trial, 5158 (6.1%) only after the first published trial, and 71,605 (84.2%) had no trials with significant very large effects. Nominally significant very large effects typically appeared in small trials with median number of events: 18 in first trials and 15 in subsequent trials. Topics with very large effects were less likely than other topics to address mortality (3.6% in first trials, 3.2% in subsequent trials, and 11.6% in no trials with significant very large effects) and were more likely to address laboratory-defined efficacy (10% in first trials,10.8% in subsequent, and 3.2% in no trials with significant very large effects). First trials with very large effects were as likely as trials with no very large effects to have subsequent published trials. Ninety percent and 98% of the very large effects observed in first and subsequently published trials, respectively, became smaller in meta-analyses that included other trials; the median odds ratio decreased from 11.88 to 4.20 for first trials, and from 10.02 to 2.60 for subsequent trials. For 46 of the 500 selected topics (9.2%; first and subsequent trials) with a very large-effect trial, the meta-analysis maintained very large effects with P < .001 when additional trials were included, but none pertained to mortality-related outcomes. Across the whole CDSR, there was only 1 intervention with large beneficial effects on mortality, P < .001, and no major concerns about the quality of the evidence (for a trial on extracorporeal oxygenation for severe respiratory failure in newborns). CONCLUSIONS: Most large treatment effects emerge from small studies, and when additional trials are performed, the effect sizes become typically much smaller. Well-validated large effects are uncommon and pertain to nonfatal outcomes. |
nfcorpus-qrel-MED-1484 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Estimating Health Care-Associated Infections and Deaths in U.S. Hospitals, 2002
SYNOPSIS Objective The purpose of this study was to provide a national estimate of the number of healthcare-associated infections (HAI) and deaths in United States hospitals. Methods No single source of nationally representative data on HAIs is currently available. The authors used a multi-step approach and three data sources. The main source of data was the National Nosocomial Infections Surveillance (NNIS) system, data from 1990–2002, conducted by the Centers for Disease Control and Prevention. Data from the National Hospital Discharge Survey (for 2002) and the American Hospital Association Survey (for 2000) were used to supplement NNIS data. The percentage of patients with an HAI whose death was determined to be caused or associated with the HAI from NNIS data was used to estimate the number of deaths. Results In 2002, the estimated number of HAIs in U.S. hospitals, adjusted to include federal facilities, was approximately 1.7 million: 33,269 HAIs among newborns in high-risk nurseries, 19,059 among newborns in well-baby nurseries, 417,946 among adults and children in ICUs, and 1,266,851 among adults and children outside of ICUs. The estimated deaths associated with HAIs in U.S. hospitals were 98,987: of these, 35,967 were for pneumonia, 30,665 for bloodstream infections, 13,088 for urinary tract infections, 8,205 for surgical site infections, and 11,062 for infections of other sites. Conclusion HAIs in hospitals are a significant cause of morbidity and mortality in the United States. The method described for estimating the number of HAIs makes the best use of existing data at the national level. |
nfcorpus-qrel-MED-1490 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Are preventive drugs preventive enough? A study of patients' expectation of benefit from preventive drugs.
OBJECTIVES: The study aimed to find the threshold of benefit for a hypothetical cholesterol-lowering drug below which the subject would not be prepared to take the drug. We also looked at whether proximity to the target event (myocardial infarction) and the subjects' views on drug taking affected this threshold. DESIGN: We studied 307 subjects using a written questionnaire and interview. Group 1 (102 subjects) had just been discharged from the coronary care unit. Group 2 (105 subjects) were taking cardio-protective drugs but had no recent history of myocardial infarction. Group 3 (100 subjects) had no history of myocardial infarction and were taking no cardio-protective drugs. RESULTS: Median values for the threshold of benefit below which the subject would not take the preventive drug were 20%, 20%, and 30% absolute risk reduction for Groups 1, 2 and 3 respectively. Median values for expectation of average prolongation of life were 12, 12 and 18 months respectively. Only 27% of subjects would take a drug offering 5% or less absolute risk reduction over five years. Subjects' views on medicinal drug taking in general and proximity to the target event were predictors of the acceptance of preventive drugs. Eighty percent of subjects wished to be told the numerical benefit of a preventive drug before starting on it. CONCLUSION: For the majority, the expectation of benefit from a preventive drug is higher than the actual benefit provided by current drug strategies. There is a tension between the patient's right to know about the chance of benefiting from a preventive drug and the likely reduction in uptake if they are so informed. |
nfcorpus-qrel-MED-3113 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | The emergence of "lifestyle medicine" as a structured approach for management of chronic disease.
Chronic diseases with a lifestyle-based aetiology currently make up a significant proportion of primary care consultations, but management often falls between the demands of public and clinical health. A modified clinical approach, based around the concept of "lifestyle medicine", helps fill the gap by adding behavioural, motivational and environmental skills to conventional medical practice. When used in a multidisciplinary setting, lifestyle medicine offers potential cost and effectiveness benefits, which are beginning to be realised. |
nfcorpus-qrel-MED-4247 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial.
In a prospective, randomised, controlled trial to determine whether comprehensive lifestyle changes affect coronary atherosclerosis after 1 year, 28 patients were assigned to an experimental group (low-fat vegetarian diet, stopping smoking, stress management training, and moderate exercise) and 20 to a usual-care control group. 195 coronary artery lesions were analysed by quantitative coronary angiography. The average percentage diameter stenosis regressed from 40.0 (SD 16.9)% to 37.8 (16.5)% in the experimental group yet progressed from 42.7 (15.5)% to 46.1 (18.5)% in the control group. When only lesions greater than 50% stenosed were analysed, the average percentage diameter stenosis regressed from 61.1 (8.8)% to 55.8 (11.0)% in the experimental group and progressed from 61.7 (9.5)% to 64.4 (16.3)% in the control group. Overall, 82% of experimental-group patients had an average change towards regression. Comprehensive lifestyle changes may be able to bring about regression of even severe coronary atherosclerosis after only 1 year, without use of lipid-lowering drugs. |
nfcorpus-qrel-MED-3623 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Pediatric CT research elevates public health concerns: low-dose radiation issues are highly politicized.
This article presents an analysis of issues related to low-dose radiation, with a focus on pediatric computed tomography (CT). It references several early studies that are seldom quoted in radiation research papers, then quantifies the excess lifetime fatal cancer yield attributable to an estimated 6.5 million pediatric abdominal CT scans. The authors highlight an important policy document issued jointly by the National Cancer Institute and the Society for Pediatric Radiology--specifically, its conclusion that a small dose from CT represents "a public health concern." Finally, the article identifies several contentious issues and proposes policy initiatives that, if implemented, could result in significant reductions of future radiogenic cancers and chronic injuries. The authors call for discussions between professional radiology societies and public interest health organizations, thereby involving all stakeholders. |
nfcorpus-qrel-MED-3624 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Estimated risks of radiation-induced fatal cancer from pediatric CT.
OBJECTIVE: In light of the rapidly increasing frequency of pediatric CT examinations, the purpose of our study was to assess the lifetime cancer mortality risks attributable to radiation from pediatric CT. MATERIALS AND METHODS: Organ doses as a function of age-at-diagnosis were estimated for common CT examinations, and estimated attributable lifetime cancer mortality risks (per unit dose) for different organ sites were applied. Standard models that assume a linear extrapolation of risks from intermediate to low doses were applied. On the basis of current standard practice, the same exposures (milliampere-seconds) were assumed, independent of age. RESULTS: The larger doses and increased lifetime radiation risks in children produce a sharp increase, relative to adults, in estimated risk from CT. Estimated lifetime cancer mortality risks attributable to the radiation exposure from a CT in a 1-year-old are 0.18% (abdominal) and 0.07% (head)-an order of magnitude higher than for adults-although those figures still represent a small increase in cancer mortality over the natrual background rate. In the United States, of approximately 600,000 abdominal and head CT examinations annually performed in children under the age of 15 years, a rough estimate is that 500 of these individuals might ultimately die from cancer attributable to the CT radiation. CONCLUSION: The best available risk estimates suggest that pediatric CT will result in significantly increased lifetime radiation risk over adult CT, both because of the increased dose per milliampere-second, and the increased lifetime risk per unit dose. Lower milliampere-second settings can be used for children without significant loss of information. Although the risk-benefit balance is still strongly tilted toward benefit, because the frequency of pediatric CT examinations is rapidly increasing, estimates that quantitative lifetime radiation risks for children undergoing CT are not negligible may stimulate more active reduction of CT exposure settings in pediatric patients. |
nfcorpus-qrel-MED-3625 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Informed consent and communication of risk from radiological and nuclear medicine examinations: how to escape from a communication inferno
Short abstract Radiological and nuclear medicine examinations confer a definite (albeit low) long term risk of cancer, but patients undergoing such examinations often receive no or inaccurate information about these risks. Picano argues that this disregard of patient autonomy is no longer acceptable and suggests a practicable way of communicating risk |
nfcorpus-qrel-MED-3626 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Justification of diagnostic medical exposures: some practical issues. Report of an International Atomic Energy Agency Consultation
Objectives The Radiation Protection of Patients Unit of the International Atomic Energy Agency (IAEA) is concerned about the effectiveness of justification of diagnostic medical exposures. Recent published work and the report of an initial IAEA consultation in the area gave grounds for such concerns. There is a significant level of inappropriate usage, and, in some cases, a poor level of awareness of dose and risk among some key groups involved. This article aims to address this. Methods The IAEA convened a second group of experts in November 2008 to review practical and achievable actions that might lead to more effective justification. Results This report summarises the matters that this group considered and the outcome of their deliberations. There is a need for improved communication, both within professions and between professionals on one hand, and between professionals and the patients/public on the other. Coupled with this, the issue of consent to imaging procedures was revisited. The need for good evidence-based referral guidelines or criteria of acceptability was emphasised, as was the need for their global adaptation and dissemination. Conclusion Clinical audit was regarded as a key tool in ensuring that justification becomes an effective, transparent and accountable part of normal radiological practice. In summary, justification would be facilitated by the “3 As”: awareness, appropriateness and audit. |
nfcorpus-qrel-MED-3627 | Generate text that best answers this question: How Doctors Responded to Being Named a Leading Killer | Projected cancer risks from computed tomographic scans performed in the United States in 2007.
BACKGROUND: The use of computed tomographic (CT) scans in the United States (US) has increased more than 3-fold since 1993 to approximately 70 million scans annually. Despite the great medical benefits, there is concern about the potential radiation-related cancer risk. We conducted detailed estimates of the future cancer risks from current CT scan use in the US according to age, sex, and scan type. METHODS: Risk models based on the National Research Council's "Biological Effects of Ionizing Radiation" report and organ-specific radiation doses derived from a national survey were used to estimate age-specific cancer risks for each scan type. These models were combined with age- and sex-specific scan frequencies for the US in 2007 obtained from survey and insurance claims data. We estimated the mean number of radiation-related incident cancers with 95% uncertainty limits (UL) using Monte Carlo simulations. RESULTS: Overall, we estimated that approximately 29 000 (95% UL, 15 000-45 000) future cancers could be related to CT scans performed in the US in 2007. The largest contributions were from scans of the abdomen and pelvis (n = 14 000) (95% UL, 6900-25 000), chest (n = 4100) (95% UL, 1900-8100), and head (n = 4000) (95% UL, 1100-8700), as well as from chest CT angiography (n = 2700) (95% UL, 1300-5000). One-third of the projected cancers were due to scans performed at the ages of 35 to 54 years compared with 15% due to scans performed at ages younger than 18 years, and 66% were in females. CONCLUSIONS: These detailed estimates highlight several areas of CT scan use that make large contributions to the total cancer risk, including several scan types and age groups with a high frequency of use or scans involving relatively high doses, in which risk-reduction efforts may be warranted. |
arguana-qrel-test-environment-aeghhgwpe-pro02b | Generate text that refutes this claim: Being vegetarian helps the environment Becoming a vegetarian is an environmentally friendly thing to do. Modern farming is one of the main sources of pollution in our rivers. Beef farming is one of the main causes of deforestation, and as long as people continue to buy fast food in their billions, there will be a financial incentive to continue cutting down trees to make room for cattle. Because of our desire to eat fish, our rivers and seas are being emptied of fish and many species are facing extinction. Energy resources are used up much more greedily by meat farming than my farming cereals, pulses etc. Eating meat and fish not only causes cruelty to animals, it causes serious harm to the environment and to biodiversity. For example consider Meat production related pollution and deforestation At Toronto’s 1992 Royal Agricultural Winter Fair, Agriculture Canada displayed two contrasting statistics: “it takes four football fields of land (about 1.6 hectares) to feed each Canadian” and “one apple tree produces enough fruit to make 320 pies.” Think about it — a couple of apple trees and a few rows of wheat on a mere fraction of a hectare could produce enough food for one person! [1] The 2006 U.N. Food and Agriculture Organization (FAO) report concluded that worldwide livestock farming generates 18% of the planet's greenhouse gas emissions — by comparison, all the world's cars, trains, planes and boats account for a combined 13% of greenhouse gas emissions. [2] As a result of the above point producing meat damages the environment. The demand for meat drives deforestation. Daniel Cesar Avelino of Brazil's Federal Public Prosecution Office says “We know that the single biggest driver of deforestation in the Amazon is cattle.” This clearing of tropical rainforests such as the Amazon for agriculture is estimated to produce 17% of the world's greenhouse gas emissions. [3] Not only this but the production of meat takes a lot more energy than it ultimately gives us chicken meat production consumes energy in a 4:1 ratio to protein output; beef cattle production requires an energy input to protein output ratio of 54:1. The same is true with water use due to the same phenomenon of meat being inefficient to produce in terms of the amount of grain needed to produce the same weight of meat, production requires a lot of water. Water is another scarce resource that we will soon not have enough of in various areas of the globe. Grain-fed beef production takes 100,000 liters of water for every kilogram of food. Raising broiler chickens takes 3,500 liters of water to make a kilogram of meat. In comparison, soybean production uses 2,000 liters for kilogram of food produced; rice, 1,912; wheat, 900; and potatoes, 500 liters. [4] This is while there are areas of the globe that have severe water shortages. With farming using up to 70 times more water than is used for domestic purposes: cooking and washing. A third of the population of the world is already suffering from a shortage of water. [5] Groundwater levels are falling all over the world and rivers are beginning to dry up. Already some of the biggest rivers such as China’s Yellow river do not reach the sea. [6] With a rising population becoming vegetarian is the only responsible way to eat. [1] Stephen Leckie, ‘How Meat-centred Eating Patterns Affect Food Security and the Environment’, International development research center [2] Bryan Walsh, Meat: Making Global Warming Worse, Time magazine, 10 September 2008 . [3] David Adam, Supermarket suppliers ‘helping to destroy Amazon rainforest’, The Guardian, 21st June 2009. [4] Roger Segelken, U.S. could feed 800 million people with grain that livestock eat, Cornell Science News, 7th August 1997. [5] Fiona Harvey, Water scarcity affects one in three, FT.com, 21st August 2003 [6] Rupert Wingfield-Hayes, Yellow river ‘drying up’, BBC News, 29th July 2004 | animals environment general health health general weight philosophy ethics
You don’t have to be vegetarian to be green. Many special environments have been created by livestock farming – for example chalk down land in England and mountain pastures in many countries. Ending livestock farming would see these areas go back to woodland with a loss of many unique plants and animals. Growing crops can also be very bad for the planet, with fertilisers and pesticides polluting rivers, lakes and seas. Most tropical forests are now cut down for timber, or to allow oil palm trees to be grown in plantations, not to create space for meat production. British farmer and former editor Simon Farrell also states: “Many vegans and vegetarians rely on one source from the U.N. calculation that livestock generates 18% of global carbon emissions, but this figure contains basic mistakes. It attributes all deforestation from ranching to cattle, rather than logging or development. It also muddles up one-off emissions from deforestation with on-going pollution.” He also refutes the statement of meat production inefficiency: “Scientists have calculated that globally the ratio between the amounts of useful plant food used to produce meat is about 5 to 1. If you feed animals only food that humans can eat — which is, indeed, largely the case in the Western world — that may be true. But animals also eat food we can't eat, such as grass. So the real conversion figure is 1.4 to 1.” [1] At the same time eating a vegetarian diet may be no more environmentally friendly than a meat based diet if it is not sustainably sourced or uses perishable fruit and vegetables that are flown in from around the world. Eating locally sourced food can has as big an impact as being vegetarian. [2] [1] Tara Kelly, Simon Fairlie: How Eating Meat Can Save the World, 12 October 2010 [2] Lucy Siegle, ‘It is time to become a vegetarian?’ The Observer, 18th May 2008 |
arguana-qrel-test-environment-aeghhgwpe-pro01b | Generate text that refutes this claim: It is immoral to kill animals As evolved human beings it is our moral duty to inflict as little pain as possible for our survival. So if we do not need to inflict pain to animals in order to survive, we should not do it. Farm animals such as chickens, pigs, sheep, and cows are sentient living beings like us - they are our evolutionary cousins and like us they can feel pleasure and pain. The 18th century utilitarian philosopher Jeremy Bentham even believed that animal suffering was just as serious as human suffering and likened the idea of human superiority to racism. It is wrong to farm and kill these animals for food when we do not need to do so. The methods of farming and slaughter of these animals are often barbaric and cruel - even on supposedly 'free range' farms. [1] Ten billion animals were slaughtered for human consumption each year, stated PETA. And unlike the farms long time ago, where animals roamed freely, today, most animals are factory farmed: crammed into cages where they can barely move and fed a diet adulterated with pesticides and antibiotics. These animals spend their entire lives in their “prisoner cells” so small that they can't even turn around. Many suffer serious health problems and even death because they are selectively bred to grow or produce milk or eggs at a far greater rate than their bodies are capable of coping with. At the slaughterhouse, there were millions of others who are killed every year for food. Further on Tom Regan explains that all duties regarding animals are indirect duties to one another from a philosophical point of view. He illustrates it with an analogy regarding children: “Children, for example, are unable to sign contracts and lack rights. But they are protected by the moral contract nonetheless because of the sentimental interests of others. So we have, then, duties involving these children, duties regarding them, but no duties to them. Our duties in their case are indirect duties to other human beings, usually their parents.” [2] With this he supports the theory that animals must be protected from suffering, as it is moral to protect any living being from suffering, not because we have a moral contract with them, but mainly due to respect of life and recognition of suffering itself. [1] Claire Suddath, A brief history of Veganism, Time, 30 October 2008 [2] Tom Regan, The case for animal rights, 1989 | animals environment general health health general weight philosophy ethics
There is a great moral difference between humans and animals. Unlike animals, humans are capable of rational thought and can alter the world around them. Other creatures were put on this earth for mankind to use, and that includes eating meat. For all these reasons we say that men and women have rights and that animals don’t. This means that eating meat is in no way like murder. It is natural for human beings to farm, kill, and eat other species. In the wild there is a brutal struggle for existence. The fact that we humans have succeeded in that struggle by exploiting our natural environment means that we have a natural right over lower species. In fact farming animals is much less brutal than the pain and hardship that animals inflict on each other naturally in the wild. Eating meat does not need to mean cruelty to animals. There are a growing number of organic and free-range farms that can provide meat without cruelty to animals. Similarly, it might be reasonable to argue for an extension of animal welfare laws to protect farm animals - but that does not mean that it is wrong in principle to eat meat. |
arguana-qrel-test-environment-aeghhgwpe-pro03b | Generate text that refutes this claim: Vegetarianism is healthier There are significant health benefits to 'going veggie'; a vegetarian diet contains high quantities of fibre, vitamins, and minerals, and is low in fat. (A vegan diet is even better since eggs and dairy products are high in cholesterol.) The risk of contracting many forms of cancer is increased by eating meat: in 1996 the American Cancer Society recommended that red meat should be excluded from the diet entirely. Eating meat also increases the risk of heart disease - vegetables contain no cholesterol, which can build up to cause blocked arteries in meat-eaters. An American study found out that: “that men in the highest quintile of red-meat consumption — those who ate about 5 oz. of red meat a day, roughly the equivalent of a small steak had a 31% higher risk of death over a 10-year period than men in the lowest-consumption quintile, who ate less than 1 oz. of red meat per day, or approximately three slices of corned beef.” [1] A vegetarian diet reduces the risk for chronic degenerative diseases such as obesity, high blood pressure, diabetes and types of cancer including colon, breast, stomach, and lung cancer because of it's low fat/cholesterol content. There are plenty of vegetarian sources of protein, such as beans and bean curd; and spinach is one of the best sources of iron. [1] Tiffany Sharples, ‘The Growing Case Against Red Meat’, Time, 23rd March 2009 | animals environment general health health general weight philosophy ethics
The key to good health is a balanced diet, not a meat- and fish-free diet. Meat and fish are good sources of protein, iron, and other vitamins and minerals. Most of the health benefits of a vegetarian diet derive from its being high in fibre and low in fat and cholesterol. These can be achieved by avoiding fatty and fried foods, eating only lean grilled meat and fish, and including a large amount of fruit and vegetables in your diet along with meat and fish. In general, raw, unprocessed meat from the muscle is made up of the following: protein 15 - 22 % Fat 3 - 15 % Minerals, carbohydrates 1 - 5 % Water 65 - 75 %, all things that we need in moderation. [1] A meat- and fish-free diet is unbalanced and makes it more likely that you will go short of protein, iron and some minerals such as B12 for which we are primarily dependent on animal foodstuffs. Also, a vegetarian diet, in the West, is a more expensive option - a luxury for the middle classes. Fresh fruit and vegetables are extremely expensive compared to processed meats, bacon, burgers, sausages etc. [1] Bell, ‘Nutrition & Well-Being’ |
arguana-qrel-test-environment-aeghhgwpe-pro04b | Generate text that refutes this claim: Being vegetarian reduces risks of food poisoning Almost all dangerous types of food poisoning are passed on through meat or eggs. So Campylobacter bacteria, the most common cause of food poisoning in England, are usually found in raw meat and poultry, unpasteurised milk and untreated water. Salmonella come from raw meat, poultry and dairy products and most cases of escherichia coli (E-Coli) food poisoning occur after eating undercooked beef or drinking unpasteurised milk. [1] Close contact between humans and animals also leads to zoonosis – diseases such as bird ‘flu which can be passed on from animals to humans. Using animal brains in the processed feed for livestock led to BSE in cattle and to CJD in humans who ate beef from infected cows. [1] Causes of food poisoning, nhs.co.uk, 23rd June 2009 | animals environment general health health general weight philosophy ethics
Food safety and hygiene are very important for everyone, and governments should act to ensure that high standards are in place particularly in restaurants and other places where people get their food from. But food poisoning can occur anywhere “People don't like to admit that the germs might have come from their own home” [1] and while meat is particularly vulnerable to contamination there are bacteria that can be transmitted on vegetables, for example Listeria monocytogenes can be transmitted raw vegetables. [2] Almost three-quarters of zoonotic transmissions are caused by pathogens of wildlife origin; even some that could have been caused by livestock such as avian flu could equally have come from wild animals. There is little we can do about the transmission of such diseases except by reducing close contact. Thus changing to vegetarianism may reduce such diseases by reducing contact but would not eliminate them. [3] Just as meat production can raise health issues, so does the arable farming of plants – examples include GM crops and worries about pesticide residues on fruit and vegetables. The important thing is not whether the diet is meat based or vegetarian; just that we should ensure all food is produced in a safe and healthy way. [1] ‘ 10 ways to prevent food poisoning’, nhs.co.uk, 28th November 2010. [2] Food Poisoning, emedicinehealth. [3] Ulrich Desselberger, ‘The significance of zoonotic transmission of viruses in human disease’, Microbiology Today, November 2009. |
arguana-qrel-test-environment-aeghhgwpe-con02b | Generate text that refutes this claim: There are problems with being vegetarian A vegetarian or vegan diet may result in a person not getting enough iron. This is because, although you can get iron from foods such as pulses, green leafy vegetables and nuts, the iron in these foods isn't absorbed so easily. The symptoms of this feeling breathless after little exercise, feeling tired and a short attention span and poor concentration. [1] These symptoms could negatively affect proficiency in school and the ability to perform well at work ultimately leading to a loss of productivity which has both personal effects and broader effects for the economy. Other conditions include frequently becoming ill, frequently becoming depressed, and malnourishment. [1] Bupa's Health Information Team, ‘Iron-deficiency anaemia’, bupa.co.uk, March 2010, | animals environment general health health general weight philosophy ethics
The problems with fatigue, apathetic behaviour and concentration are mostly a result from a lack of iron in the diet. However as with any diet this is only a problem when not eating the right things, this regularly means that such iron deficiency can be a problem in the developing world where vegetarians have little choice – usually eating little else except what they grow, normally just cereals. “Although the iron stores of vegetarians are sometimes reduced, the incidence of iron-deficiency anaemia in vegetarians is not significantly different from that in the general population”, there are plenty of sources of iron that can be eaten by vegetarians such as legumes and whole grains that are a substantial part of most western vegetarian’s diets meaning it is not a problem. [1] Research done in Australia concludes that "There was no significant difference between mean daily iron intakes of vegetarians and omnivores". [2] [1] David Ogilvie, Nutrition: Iron and Vegetarian Diets, Vegetarian Network Victoria, September 2010. [2] Madeleine J Ball and Melinda A Bartlett, ‘Dietary intake and iron status of Australian vegetarian women’, American Society for Clinical Nutrition, 1999 |
arguana-qrel-test-environment-aeghhgwpe-con03b | Generate text that refutes this claim: Survival of the fittest It is natural for human beings to farm, kill, and eat other species. In the wild there is a brutal struggle for existence as is shown by Darwin’s On the Origin of the Species. [1] The fact that we humans have succeeded in that struggle by exploiting our natural environment means that we have a natural right over lower species. The concept of survival of the fittest may seem outdated but it is still the defining order of nature. In fact farming animals is much less brutal than the pain and hardship that animals inflict on each other naturally in the wild. [1] Darwin, Charles, On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life., Literature.org | animals environment general health health general weight philosophy ethics
To suggest that battery farms are in some way 'natural' is absurd - they are unnatural and cruel. To eat meat is to perpetuate animal suffering on a huge scale - a larger, crueler, and more systematic scale than anything found in the wild. Furthermore, the very fact of humanity's 'superiority' over other animals means they have the reason and moral instinct to stop exploiting other species. If an alien species from another planet, much more intelligent and powerful than humans, came and colonized the earth and farmed (and force-fed) human beings in battery farm conditions we would think it was morally abhorrent. If this would be wrong, then is it not wrong for we 'superior' humans to farm 'lower' species on earth simply because of our ability to do so? |
arguana-qrel-test-environment-aeghhgwpe-con01b | Generate text that refutes this claim: Humans can choose their own nutrition plan Humans are omnivores – we are meant to eat both meat and plants. Like our early ancestors we have sharp canine teeth for tearing animal flesh and digestive systems adapted to eating meat and fish as well as vegetables. Our stomachs are also adapted to eating both meat and vegetable matter. All of this means that eating meat is part of being human. Only in a few western countries are people self-indulgent enough to deny their nature and get upset about a normal human diet. We were made to eat both meat and vegetables - cutting out half of this diet will inevitably mean we lose that natural balance. Eating meat is entirely natural. Like many other species, human beings were once hunters. In the wild animals kill and are killed, often very brutally and with no idea of “rights”. As mankind has progressed over thousands of years we have largely stopped hunting wild animals. Instead we have found kinder and less wasteful ways of getting the meat in our diets through domestication. Farm animals today are descended from the animals we once hunted in the wild. | animals environment general health health general weight philosophy ethics
Human evolved as omnivores over thousands of years. Yet since the invention of farming there is no longer a need for us to be omnivores. Even if we wished to we could no longer collect, hunt and eat our food in the same way as our ancestors as we could not support the human population. We have outstripped the pace of our evolution and if we do not want to be turning ever more land over to farming we have get our food from the most efficient sources, which means being vegetarian. |
arguana-qrel-test-environment-assgbatj-pro02b | Generate text that refutes this claim: Animal research causes severe harm to the animals involved The point of animal research is that animals are harmed. Even if they don’t suffer in the experiment, almost all are killed afterwards. With 115 million animals used a year this is a big problem. Releasing medical research animals in to the wild would be dangerous for them, and they would not be usable as pets. [4]. The only solution is that they are wild from birth. It is obvious that it’s not in the interest of animals to be killed or harmed. Research should be banned in order to prevent the deaths of millions of animals. | animals science science general ban animal testing junior
What then is the interest of the animal? If releasing these animals into the wild would kill them then surely it is humane to put them down after the experiment. It must also be remembered that the interest of the animal is not the main and is outweighed by the benefits to humans. [5] |
arguana-qrel-test-environment-assgbatj-pro05b | Generate text that refutes this claim: It would send out a consistent message Most countries have animal welfare laws to prevent animal cruelty but have laws like the UK’s Animals (Scientific Procedures) Act 1986, [10] that stop animal testing being a crime. This makes means some people can do things to animals, but not others. If the government are serious about animal abuse, why allow anyone to do it? | animals science science general ban animal testing junior
There is a moral difference between harm for the sake of harming an animal and harm in order to save lives. Lifesaving drugs is a very different purpose to betting or enjoyment that animal welfare laws are aimed at. |
arguana-qrel-test-environment-assgbatj-pro01b | Generate text that refutes this claim: Animals shouldn’t be harmed The difference between us and other animals is a matter of degree rather than type [2]. Their bodies resemble ours, as do their ways of conveying meaning. They recoil from pain, appear to express fear of a tormentor, and appear to take pleasure in activities; a point clear to anyone who has observed a pet dog on hearing the word “walk”. We believe other people experience feelings like us because they are like us in appearance and behaviour. An animal sharing our anatomical, physiological, and behavioural characteristics is surely likely to have feelings like us. If people have a right to not be harmed, we must ask ourselves what makes animals different? If animals feel what we feel, and suffer like us, to condemn one to testing because of them being of a different species is similar to racism or sexism.[3] | animals science science general ban animal testing junior
The right of a human not to be harmed is based not on appearance but on not harming others. Animals don’t participate in this. Animals won’t stop hunting because of the pain and feelings of other animals. Even if animal testing were to be abolished people would still eat meat, and kill animals for other less worthwhile reasons than animal testing. |
arguana-qrel-test-environment-assgbatj-pro03b | Generate text that refutes this claim: It isn’t necessary We don’t know how we will be able to develop new drugs without animal testing until we end it. We now know how most chemicals work, and computer simulations of chemicals are very good.[6] Experimenting on tissue can show how drugs work, without the need for actual animals. Even skin left over from surgery can be experiment on, and being human, is more useful. The fact that animal research was needed in the past isn’t a good excuse any more. We still have all the advancements from animal testing in the past, but it’s no longer needed. [7] | animals science science general ban animal testing junior
The laws that restrict animal testing only allow it where it’s needed. Animal testing isn’t cheap, meaning that if universities and the drug industry have a good reason to end it if they can. If we ban animal testing we won’t know what it would be able to do in the future. Animal research now has better results than other ways of doing research. [8] |
arguana-qrel-test-environment-assgbatj-pro04b | Generate text that refutes this claim: Most animals can suffer more than some people It’s possible to think of people that can’t suffer, like those in a persistent vegetative state, or with significant intellectual disabilities. We could go for one of three options. Either we could experiment on animals, but not such people, which is morally not consistent. We could allow both, but do we want to do painful medical research on the disabled? Or, we could do neither.[9] | animals science science general ban animal testing junior
The decision to test is not based upon the capacity to suffer. But it should be remembered that the individual being tested would not be the only one who suffers, for the intellectually disabled we must remember their families would suffer as well. |
arguana-qrel-test-environment-assgbatj-con02b | Generate text that refutes this claim: People will die if we don’t do animal testing Every year, 23 new drugs are introduced in the UK alone.[13] Almost all will be tested on animals. A new drug will be used for a long time. Think of all the people saved by the use of penicillin. If drugs cost more to test, that means drug companies will develop less. This means more people suffering and dying | animals science science general ban animal testing junior
Many of these drugs are “me too” drugs – ones with a slight change that doesn’t make much difference to an existing drug. [14] So often the benefits from animal testing are marginal, and even if there was a slight increase in human suffering, it would be worth it based on the animal suffering saved. |
arguana-qrel-test-environment-assgbatj-con05b | Generate text that refutes this claim: Research animals are well treated Animals used in research generally don’t suffer. While they may be in pain, they are generally given pain killers, and when they are put down this is done humanely. [16] They are looked after, as healthy animals mean better experimental results. These animals live better lives than they would in the wild. As long as animals are treated well there shouldn’t be a moral objection to animal research. This is exactly the same as with raising animals that will be used for meat. | animals science science general ban animal testing junior
Just because an animal is treated well as it is brought up doesn’t stop the very real suffering during testing. Stricter rules and painkillers don’t help as the lack of suffering cannot be guaranteed – if we knew what would happen, we wouldn’t do the experiment. |
arguana-qrel-test-environment-assgbatj-con04b | Generate text that refutes this claim: Animal research is only used when it’s needed EU member states and the US have laws to stop animals being used for research if there is any alternative. The 3Rs principles are commonly used. Animal testing is being Refined for better results and less suffering, Replaced, and Reduced in terms of the number of animals used. This means that less animals have to suffer, and the research is better. | animals science science general ban animal testing junior
Not every country has laws like the EU or the US. In countries with low welfare standards animal testing is a more attractive option. Animal researchers tend to only do animal research so don’t know about the alternatives. As a result they will use animal testing unnecessarily not as just a last resort. |
arguana-qrel-test-environment-assgbatj-con03b | Generate text that refutes this claim: Testing is needed for really new drugs The real benefit of animal testing is making totally new drugs, which is about a quarter of them. After non-animal and then animal tests, it will be tested on humans. The reason why the risk is low (but not non-existent) for these brave volunteers, is because of the animal tests. These new chemicals are the ones most likely to produce improvements to people’s lives, because they are new. You couldn’t do research on these new drugs without either animal testing or putting humans at a much higher risk. | animals science science general ban animal testing junior
When a drug is first tested on human volunteers, they are only given a tiny fraction of the amount shown safe to give to primates showing there is another way, to start with very low doses. Animal research isn’t a reliable indicator of how a drug will work in people – even with animal testing, some drugs trials go very wrong [15]. |
arguana-qrel-test-environment-assgbatj-con01b | Generate text that refutes this claim: Animals don’t have human rights Humans have large brains, form social groups, communicate and are generally worthy of moral consideration. We also are aware of ourselves and of the nature of death. Some animals have some of these characteristics but not all so should not have the same rights. In harming animals to benefit humans, we enter in to a good moral trade-off to create a greater good. [11] | animals science science general ban animal testing junior
To argue that “the ends justify the means” isn’t enough. We don’t know how much animals suffer, as they can’t talk to us. We therefore don’t know how aware they are of themselves. In order to stop a moral harm on animals we don’t understand, we shouldn’t do animal testing. Even if it were a “net gain” because of the results, by that logic human experimentation could be justified. Common morality says that isn’t OK, as people shouldn’t be used to a means to an end. [12] |
arguana-qrel-test-environment-aiahwagit-pro02b | Generate text that refutes this claim: Poaching is becoming more advanced A stronger, militarised approach is needed as poaching is becoming far more advanced. Poachers now operate with high-calibre rifles, night vision scopes, silencers and use helicopters to hunt their prey. [1] These methods are used particularly against rhinoceroses in South Africa, whose horns have become extremely valuable on the Asian market for their supposed medical properties. [2] In response to this, South African rangers are being given specialised training and use their own aerial surveillance to track poachers down with success, [3] supporting the argument for a militarised response to protect endangered animals. [1] WWF, ‘African rhino poaching crisis’ [2] Zapwing, ‘The Rhino Poaching Crisis’ [3] ibid | animals international africa house would african government implement tougher
Tougher protection of Africa’s nature reserves will only result in more bloodshed. Every time the military upgrade their weaponry, tactics and logistic, the poachers improve their own methods to counter them. In the past decade, over 1,000 rangers have been killed whilst protecting Africa’s endangered wildlife. [1] Every time one side advances its position the other side matches it. When armed military patrols were sent out, poachers switched their tactics so every hunter has several ‘guards’ to combat the military. The lack of an advantageous position in the arms race has ensured that the poaching war is yet to be won. [2] [1] Smith, D. ‘Execute elephant poachers on the spot, Tanzanian minister urges’ [2] Welz, A. ‘The War on African Poaching: Is Militarization Fated to Fail?’ |
arguana-qrel-test-environment-aiahwagit-pro05b | Generate text that refutes this claim: The justice system does not currently work A major failing in current anti-poaching operations is that the poachers are rarely prosecuted. African legal systems rarely prioritise poaching as a serious crime, with offenders usually receiving trivial fines1. One of the major reasons for the Western black rhinoceros’ extinction in 2011 was the complete lack of sentencing for any of the poachers who were captured. [1] The system also fails to prosecute the brains behind many of the operations due to poor investigative methods. This creates an impression in the minds of the poachers that they can operate with impunity. [2] [1] Mathur, A. ‘Western Black Rhino Poached Out of Existence; Declared Extinct, Slack Anti-Poaching Efforts Responsible’ [2] Welz, A. ‘The War on African Poaching: Is Militarization Fated to Fail?’ | animals international africa house would african government implement tougher
Deterrents in the criminal justice system have not worked in similar cases. The US drug war, which identified a specific activity and made it a matter of national security, has resulted in harsh sentences for those who deal or smuggle illicit substances. Despite these harsh punishments however, there has been little success in defeating the drug business as the profit margin for the trade is too high. [1] With Ivory and other products for which poachers are hunting the same will happen; if some poachers are put up the prices will simply go up encouraging others. Tougher protection of animals through increased conviction rates and extended terms is likely to fail. [1] BBC, “Global war on drugs ‘has failed’ says former leaders’ |
arguana-qrel-test-environment-aiahwagit-pro01b | Generate text that refutes this claim: Natural habitats being are destroyed A tougher approach to the protection of animals is needed to prevent their natural habitats from being destroyed by locals. As humans expand their agricultural activity in Africa they are destroying the environments of endangered animals and pushing others towards being endangered. Due to an increase in large scale cotton plantations and food crops, the West African lion has seen a marked decrease in population; numbering less than 400 in early 2014 [1] . Tougher protection, such as fencing off areas from human activity, has been suggested and has seen success in South Africa [2] . [1] BBC, “Lions ‘facing extinction in West Africa’” [2] Morelle,R. “Fencing off wild lions from humans ‘could save them’” | animals international africa house would african government implement tougher
Human development is of great importance to the African continent, arguably more so than conserving endangered animals. In 2010 it was estimated that there are 239 million sub-Saharan Africans living in poverty. [1] Poverty can be the cause of a wide array of political, security and socio-economic issues. Possible sources of income, such as cotton plantations and food crops, should therefore be embraced as they will have a more positive impact on the region than the survival of endangered species. [1] World Hunger, ‘Africa Hunger and Poverty Facts’ |
arguana-qrel-test-environment-aiahwagit-pro03b | Generate text that refutes this claim: Endangered animals are a source of pride for African countries Endangered animals warrant a tougher degree of protection in Africa as they have notable cultural significance. Some groups believe that African elephants have mystic powers attached to them and have coveted them for centuries. [1] African lions have been depicted on the coat of arms for states and institutions both past and present. [2] They are intrinsically linked with Africa’s past and its identity. The extinction of these animals, therefore, would have a negative cultural impact and should be prevented. [1] University of California, Los Angeles, ‘Elephant: The Animal and its Ivory in African Culture’ [2] Coleman, Q. ‘The importance of African lions’ | animals international africa house would african government implement tougher
Not all endangered animals have such cultural significance within Africa. Pangolins are armoured mammals which are native to Africa and Asia. Like rhinoceros, pangolins are endangered due to their demand in East Asia. They are relatively unknown however, and therefore have little cultural significance. [1] This is the case for many of Africa’s lesser known endangered species. Any extension of protection for endangered animals based on their cultural significance would be unlikely to save many of these species. [1] Conniff, R. ‘Poaching Pangolins: An Obscure Creature Faces Uncertain Future’ |
arguana-qrel-test-environment-aiahwagit-pro04b | Generate text that refutes this claim: Poaching is linked to terrorism Stronger protection of animals should be implemented to reduce the funding for terrorist groups. Certain terrorist organisations use the illegal ivory and horn trade as funding for their operations. Al-Shabaab, the Lord’s Resistance Army (LRA), and the Sudanese Janjaweed all use the illicit trade as a source of income, with the former using the trade for 40% of its expenditure. [1] This enables them to carry out attacks such as the 2013 Westgate siege in Kenya. [2] Tougher protection of endangered animals would reduce the ability of these groups to fund themselves. In turn, this would decrease their operational capability, increasing stability in Africa. [1] Stewart, C. ‘Illegal ivory trade funds al-shabaab’s terrorist attacks’ [2] Tackett,C. ‘How elephant poaching helped fund Kenya terrorist attack’ | animals international africa house would african government implement tougher
Linking animal endangerment and poaching to terrorism as a justification for action unnecessarily securitises the issue. This will only serve to create a situation where state actors can use poaching as an excuse to exploit threats. As with the war on drugs and the war on terror, this power is apportioned to actors who are then capable of abusing it for the sake of national security. [1] [1] Crick,E. ‘Drugs as an existential threat: An analysis of the international securitization of drugs’ |
arguana-qrel-test-environment-aiahwagit-con02b | Generate text that refutes this claim: Fewer human deaths Fewer large beasts will lead to fewer deaths in Africa. Some endangered animals are aggressive and will attack humans. Hippopotamuses kill in excess of three hundred humans a year in Africa, with other animals such as the elephant and lion also causing many fatalities. [1] Footage released in early 2014 of a bull elephant attacking a tourist’s car in Kruger National Park, South Africa demonstrated the continued threat these animals cause. [2] Tougher protection would result in higher numbers of these animals which increases the risk to human lives. [1] Animal Danger ‘Most Dangerous Animals’ [2] Withnall, A. ‘Rampaging bull elephant flips over British tourist car in Kruger Park’ | animals international africa house would african government implement tougher
Most of these human deaths are caused by humans invading the territory of the animals at hand. Even giraffes, usually considered peaceful animals, will attack if they feel that humans are too close. Generally, it is the human’s responsibility rather than the animal’s. Increased protection may save more lives as methods such as fencing will forcibly separate humans from animals and decrease the chances of the two coming in to contact. [1] [1] Morelle, R. “Fencing off wild lions from humans ‘could save them’” |
arguana-qrel-test-environment-aiahwagit-con04b | Generate text that refutes this claim: Heavy handed approaches do not solve the motivations for poaching Creating tougher responses to poaching will not deter poachers as they fail to recognise the motivations for illegal hunting. Many hunters, especially those who aren’t native to Africa, take part in poaching as there is a thrill in the illegal status. [1] The close calls, challenges and sense of independence will all be multiplied by increased protection on the game reserves. Then there are those who take part out of necessity. Poachers will often be able to make $50-100 per kilogram for a rhinoceros’ horn [2] and the bush meat from kills can be a necessary source of nutrition. [3] Poaching creates opportunities for Africans which are usually unavailable in licit work. Tougher protection of animals fails to provide an alternative livelihood for these poachers. [1] Forsyth, C. & Marckese, T. ‘Thrills and skills: a sociological analysis of poaching’ pg.162 [2] Stewart, C. ‘Illegal ivory trade funds al-shabaab’s terrorist attacks’ [3] BBC, “Lions ‘facing extinction in West Africa’” | animals international africa house would african government implement tougher
If tough approaches to conservation did not exist then the situation would be far worse. [1] The lack of legislation and an armed response to the poaching threat has led to the extinction of many species, such as the Western black rhinoceros. [2] Without the boots on the ground then poaching would most likely expand due to the lack of deterrent which armed guards cause. [1] Welz, A. ‘The War on African Poaching: Is Militarization Fated to Fail?’ [2] Mathur, A. ‘Western Black Rhino Poached Out of Existence; Declared Extinct, Slack Anti-Poaching Efforts Responsible’ |
arguana-qrel-test-environment-aiahwagit-con03b | Generate text that refutes this claim: Legalising the trade of horns, ivory, furs and pelts would be more effective Making it legal for hunters to kill these endangered animals, rather than protecting them, could prevent extinction. The protected status of endangered animals has made their pelts, horns and tusks more expensive as they are harder to obtain. [1] The current illegality of trading rhino horns has constrained supply in comparison to demand in Asia. This has driven the price of the horn to around £84,000. Softening protection for endangered animals could, in theory, reduce the price to a point where it is no longer profitable to hunt these endangered animals. [2] This would potentially increase supply by freeing up that seized by governments which is currently destroyed, and could potentially involve farming as South Africa is considering with Rhino horn. [3] [1] Welz, A. ‘The War on African Poaching: Is Militarization Fated to Fail?’ [2] Player, I. & Fourie, A. ‘How to win the war against poachers’ [3] Molewa, E., ‘Statement on Rhino poaching intervention’ | animals international africa house would african government implement tougher
There is no guarantee that legalising the trade would satisfy demand in East Asia. [1] Nor is there any substantial evidence to suggest that prices would drop to the point where hunters could no longer sustain themselves. If neither of these factors transpires then there is a strong likelihood that endangered animals would be hunted to extinction. [1] Player, I. & Fourie, A. ‘How to win the war against poachers’ |
arguana-qrel-test-environment-aiahwagit-con01b | Generate text that refutes this claim: African countries have little money to spare Africa has some of the least developed countries in the world, making extensive protection of endangered animals unviable. Many African countries are burdened by the more pressing issues of civil war, large debts, poverty, and economic underdevelopment. [1] These factors already draw significant amounts of money from limited budgets. Tanzania, for example, has revenue of $5.571 billion and an expenditure of $6.706 billion. [2] Increased expenditure on animal protection projects would only serve to worsen this budget deficit. [1] Simensen, J. ‘Africa: the causes of under-development and the challenges of globalisation’ [2] The World Factbook ‘Tanzania’ | animals international africa house would african government implement tougher
There are numerous sponsors who contribute towards animal protection schemes, reducing the government’s burden. Private wildlife custodians spend significant sums of money ensuring they are fully equipped to deal with poachers. There are also private donors and interest groups such as World Wildlife Federation (WWF) who supply funding for the governments’ conservation efforts. [1] This financial support has made projects such as the increased military presence in South Africa’s game parks possible. [1] Welz, A. ‘The War on African Poaching: Is Militarization Fated to Fail?’ |
arguana-qrel-test-environment-ehwsnwu-pro02b | Generate text that refutes this claim: Underground Nuclear Storage is Safe Underground nuclear waste storage means that nuclear waste is stored at least 300m underground. [I1] The harm of a leak 300m underground is significantly limited, if the area has been chosen correctly then there should be no water sources nearby to contaminate. If this is the case, then a leak’s harm would be limited to the layers of sediment nearby which would be unaffected by radiation. By comparison a leak outside might lead to animals nearby suffering from contamination. Further nuclear waste might reach water sources should there be a leak above ground, if it is raining heavily when the leak happens for example. Further, the other options available, such as above ground storage present a potentially greater danger, should something go wrong. This is because it is much easier for nuclear waste to leak radiation into the air. This is problematic because even a hint of radiation may well cause people to panic owing to the damaging and heavily publicised consequences of previous nuclear safety crises. As such, underground storage is safer both directly and indirectly. [1] As well as this, underground storage also prevents nuclear waste or nuclear radiation from reaching other states and as such, results in greater safety across borders. [2] Further, storing all nuclear waste underground means that countries can concentrate their research and training efforts on responding to subterranean containment failures. Focus and specialisation of this type is much more likely to avert a serious release of nuclear material from an underground facility than the broad and general approach that will be fostered by diverse and distinct above-ground storage solutions. [1] “Europe eyes underground nuclear waste repositories.” Infowars Ireland. 20/02/2010 [2] “EU Debates Permanent Storage For Nuclear Waste.” 04/11/2010 AboutMyPlanet. [I1] I am not sure how to replace this section. “Leakage” of radioactive material into the air is a minimal danger. The contributor may be referring to the ejection of irradiated dust and other particulates that has occurred when nuclear power stations have suffered explosive containment failures, but this is not comparable to the types of containment failures that might happen in facilities used to store spent nuclear fuel rods and medical waste. One of the more substantial risks presented by underground storage is release of nuclear material into a water source. | energy house would store nuclear waste underground
Journalist Jeremy Shere describes the problems with most methods of nuclear storage: "There have been a few other interesting ideas –such as burying nuclear waste beneath the ocean floor. Scientists have also thought about putting waste in really deep holes, burying it in polar ice sheets, and stashing it beneath uninhabited islands. [...] But there are problems with each of these ideas. For example, it would be difficult to monitor nuclear waste under the ocean floor. Waste buried deep in the earth, meanwhile, might contaminate ground water. And as ice sheets continue to melt, it’s hard to say how long nuclear waste would remain buried, or where it would end up if it floated away. Plans to store waste produced in the United States in Yucca Mountain, in Utah, have been put on hold. So for now almost all nuclear waste is kept above ground in special containers at a few hundred different sites around the country.” [1] The point with underground nuclear storage is that geological conditions are often very different between states and regions; this would often mean that in some states underground nuclear storage would be completely inappropriate because it could leak due to geological changes. Further, underground nuclear storage as mentioned in the first opposition counterargument, actively encourages a state to become reliant on nuclear power. [1] Shere, Jeremy. “What Is The Best Way To Dispose Of Nuclear Waste?” Moment of Science. 23/03/2010 |
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